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<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MUM0</accession>
    <name>A0A4Q9MUM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_944252</name>
        <name evidence="1" type="ORF">BD311DRAFT_775957</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MUM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU31650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="13040" checksum="11E02845FC3EC9CA" modified="2019-07-31" version="1">MSEHAHSKHEEKLIQDIESRDPQFREAQMFVCFFDTSRILDAHIFDPTHRYWSTFTLECSVDSTSGSACEICVRALDPDLGCYLLAHYGSCSWNSSGIFLEAACVEGGSKSSRSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N0F7</accession>
    <name>A0A4Q9N0F7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding protein ypt1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_865232</name>
        <name evidence="11" type="ORF">BD311DRAFT_750896</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Preautophagosomal structure membrane</location>
            <topology evidence="8">Lipid-anchor</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N0F7"/>
    <dbReference type="STRING" id="114155.A0A4Q9N0F7"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000069">
        <property type="entry name" value="Ras GTP-binding protein YPT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="175"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU32371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="204" mass="22587" checksum="CC34E731353EC9DA" modified="2019-07-31" version="1">MHTSEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELEGKTVKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDNDTFTNVKQWLQEIDRYASEGVNKLLVGNKSDLTSKKVVEYSVAKEFADQLGIPFLETSAKNATNVEQAFLTMAKQIKDRMGSTTTATGTGKSTTITPGQTVQQQQGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N8M5</accession>
    <name>A0A4Q9N8M5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_911442</name>
        <name evidence="4" type="ORF">BD311DRAFT_783296</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N8M5"/>
    <dbReference type="STRING" id="114155.A0A4Q9N8M5"/>
    <dbReference type="OMA" id="GYRICIN"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044281">
        <property type="term" value="P:small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF14">
        <property type="entry name" value="DEHYDROGENASE ARBD, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU35641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="322" mass="34734" checksum="7828BB736CC55374" modified="2019-07-31" version="1">MAPSLLARTLPATSRTLLRAPRTPRTPPVQARFNSDDAAVKAKLNSIAAKARVVKTLPDFSMANKVCLVTGAARGLGNEFCRAFIQSGCTSLAIVDLKEEEAEHAAEELIKAACVDSEMEPSDYRVIGVGCDVSSELSVQQAFRRVMDTYGRVDSVVASAGIVENYSAFDYPFDRIKRLYDINVHGAFFTAREAARNMIPQGGGSVVLVASMSANIVNIPQPQTPYNAAKAAVKHMAASLGVEWAKKGVRVNTLSPGYMLTKLTRTILAHDQELKKTWESLTPMGRMGEPEDLAGAIVFLASDASRFMTGAEIRVDGGYCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAX6</accession>
    <name>A0A4Q9NAX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_833149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145272">
        <property type="protein sequence ID" value="TBU52003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAX6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18795" checksum="F3F8C53B300BE576" modified="2019-07-31" version="1">MADMTTKDSDPGTLVEHDLILLRILSLFFQSVLFGAFAMAYVTTWLSLKSTKQSQLLEKRETVLRQAITVMLLTAFFHLCLTFNVALSPTNGYEGRVDTQYLSFEDENSLFFSANGFQYYLYVTQTTIANCLLTYILYLKSNGNPKAFAPALSASVLATAFGYSASAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEM7</accession>
    <name>A0A4Q9NEM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_154742</name>
        <name evidence="4" type="ORF">BD311DRAFT_771935</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143595">
        <property type="protein sequence ID" value="TBU21577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEM7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NEM7"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU21577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22085" checksum="5772DF9A7E403260" modified="2019-07-31" version="1">MSFTDSTPSTDHHDLLAHAQDDPERVLILLDVQKNMLAEPPAGVPAGAVVGPNIAKILAYARAAVPPPRIVHVRNCGDAGEPDETGTPGWELVHTPLPGEFVVDKRKNNAFAGTELGKIIPATSEIVMVGIQSDFCIRATCSAALSRGNEVLLVRGAHATYDRIEYHNHGLITSAAEVAKEIEGELEEAGVHMLEMKDLPGLFTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGY4</accession>
    <name>A0A4Q9NGY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_930710</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGY4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="254"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="679" mass="76148" checksum="19AAAD697AA519ED" modified="2019-07-31" version="1">MWLLKTACAELEFFPTPESVPGGYAILSHVWDEHENTFQDIQAFRAKCAEATAGPSAGSPANLDTTSHPTTPITPRDLVSDKIRNFCILAEKEGYEYGWADTCCIDKTSSAELTETINSMYRYYSLADICFAYLFDVPTSPIDVLEQPKSAFQESKWHRRGWTLQELIAPESVMLLSQSWELLGSKADLAPLLESITKVPAPLLRMNTKPTDYCVAARMAWAANRETTRPEDEAYSLMGIFGIFMPALYGEGRNAFLRLQEEIMKRSQDFSIFAWGDLRTLEPHEAEPLYSVGLSLSPSASDGIFAHSPSDFLMGHDIGLAAATSRTSWHDVAPERRLRRAAGSRRRPTFHLTPYGLSADVLLFHLAVGPSVAILSGVQLKGPTRRNIGLLLQRSEETLDSKRHLYTVLDIPFRTHERGIWTGHLVPLDADNRVLWKGYLDEDALVLHKNNWMQSPVLWESICISTDGPQSAALKPLIELSSSLRHTPFRVPPSHVRELQNSLSMRNLIDRLSVIPYPLTGNPHPVPVAIMINATRHKLGRVVQCNIVYLGICSATTPGCHWALVAEEQGPPLVPASHDCSEHHIDDWHDQTRAFTITSFSPHWRPGLPRDSHQDEIRLTFRRSHLDPAIRIMHIKFVVAPELEDSGRLRTTASVDLSELSRIHDPGEVTESDEERRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKE6</accession>
    <name>A0A4Q9NKE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_834634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145338">
        <property type="protein sequence ID" value="TBU51341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKE6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26955" checksum="18773C0A3E7B147C" modified="2019-07-31" version="1">MRSLESSDRLLSWTYPAPSYACVWLACNPLHTTSTTQQPGVPPEGEPDGRRGCDAFAHHKRDRDVAHRNQSIHRRLLQEHLGEGYPSRTRVWRALALLVESGMIYCALLLAAVIDQIDQPTGPAGPTEPDSLFQNIITFFTYGCFVHIVAIYPVLIIVLVAMQRSPIDAGITQYLHLAADPSGTERNGERTSTLVFGPAEPGLSTFHNSMPDTIIELQARSKPQSDGQIEECATFDMGWDQGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMD8</accession>
    <name>A0A4Q9NMD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_926384</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMD8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF1">
        <property type="entry name" value="ALLANTOATE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="511" mass="56502" checksum="8736D15E269BC97A" modified="2019-07-31" version="1">MDHEIKDEKALHAVTVTDAESDVDLGDKDEALRLVGLESSAVFSEEYYSKLRRKLDFVIPPLCTAVYFTQYMDKTALSYASIMGFPVTGQGYNLVALSFYIGFLIWVFPSMYIAQRLRLGKYLGANIVAWGVIMMLHVLPTSFGGFFALRLLLGMLESCVAPILILIISMFYKKNEQGIRIGWFYMANGCAGIIGGFLAYGVSFIPDRGFAPWKIIYLLLGALAISVGIAVLLFMPDSPANAVMLSKEERIAAIERIRDQQGGTENKRLKKEQVVEALLDIRTWLIVLATLLTNIPNGGLANFTNIIIKGFGYTTKQTLILSTPGGAIGIASAIICGWYSDRAGERMLPIVWSLIPTLAGAGMLVGLDSSAQKGAILFASWIIGTYGSSLAIIYAYNASNTSGHTKKVTVNAMTLAAFCVANIVGTETFLPKDAPRYLPGKISILVLLTAQLGLCFVIRWVNLWMNKKKRRTLEELKQRNGWTDEDMKRERERAAFVDMTDKQNPFFEYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQ61</accession>
    <name>A0A4Q9NQ61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_933722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQ61"/>
    <dbReference type="STRING" id="114155.A0A4Q9NQ61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27609" checksum="7D75AF11608FEF7D" modified="2019-07-31" version="1">MKPTYLPSDPALTGSAQSGTGLLTDNARGEYATETIYSDLNIEQIKSISPTAFHRNVDLLVIGADEEGYARTHIVLPSTVYGIAAHPLVEAGISNPYSMQIPLIIRSSLARKRAGVIGKGLSLWPSVHIDDIADMYIVLLDSILHHPDTTGHGWEGLYFGESGEHRWLDISLAIGRAMYELGLADSPDLTPFSHEEILKYFGNEWFGYYHGTNSRARADRARALGWKPTHSTEDMLASIKPELEVYAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQ81</accession>
    <name>A0A4Q9NQ81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_934997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQ81"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13506" checksum="837F2C151D8F5B93" modified="2019-07-31" version="1">MVLKRAEIYASVSSMVCFLRRSRGYMQSVRLSEHWGRDSDRWPLKTRLVCIIIPSCCLAPRRDTQLMFVAPMFSAINCSSLRTAIHIVSDGYQHLERLDRVLSNTNMRTLLCLATAPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQN1</accession>
    <name>A0A4Q9NQN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11171" checksum="CD903D8631C70389" modified="2019-07-31" version="1">MADRPSSWCPGVMPYAMPGSFCVSSAWNRPRMSSSPLMSTDTPTPNVQPCWTSMQQPTTRPSLVQDSDFVDVFITVISVILVLPTSTRTSYHAANHGWHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NS77</accession>
    <name>A0A4Q9NS77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_810724</name>
        <name evidence="1" type="ORF">BD311DRAFT_678202</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143601">
        <property type="protein sequence ID" value="TBU21497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NS77"/>
    <dbReference type="STRING" id="114155.A0A4Q9NS77"/>
    <dbReference type="OrthoDB" id="2559662at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="365" mass="41889" checksum="A3F06D9711C23549" modified="2019-07-31" version="1">MQEHLLNAHLAHESGRAFVYNNYTWNKDGSDYTEYNGHLIPSRIPITALLRGPAAGEPWPPGDPAPRAVVKAYWDKVCPEPHRMMSEELFKIDADADAGEVLRTWVEKLKTLPRCVEIKEDAAQIWNIWVFGSKRVLGIWESLKNSPVITEFRWSQLIEDGFTRNRHLFMHTNWLRDLISPPSAYPYDVIPGLLALHIRRGDFEGHCLHFARWSSQWNGFNQFPELPDHFVPPPTAGWGEYTEEGKNIYLKHCFPDIEQIVARVAEVRATPAGKGLKNVFIMTNGKQPWVEELKREIAKTGGWDRIASSRDMKLDWEQQFVAQSVDMLIGQRAQVIIGNGFSSLTSNIVMLRMARDIPADTNRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV06</accession>
    <name>A0A4Q9NV06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_694118</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145172">
        <property type="protein sequence ID" value="TBU55247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV06"/>
    <dbReference type="STRING" id="114155.A0A4Q9NV06"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
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    </evidence>
    <sequence length="558" mass="60162" checksum="84653EB97E86444A" modified="2019-07-31" version="1">MLPPPTAKPGPSTVLSPAQTLVDGRIPQRYSVARRYLLLIIFCLAQFLDAFNNSALFSAIPSLVISLDMNESESTWIISAFQLTFASFLLISGRISDIYNPKFAFIGGVSGLGIISIGAGFVSSKIPLIVLRALSGIAASMTIPSALTLLVNVFTEPAEQARAIGVFGGCGAVGNVLGLIIGAIFVQFASWSWVFWFVALVCMPIAMLCIFLIPKQEPRLDDPAIHTGARWKSLDITGVSILTIALILFIFGVTSGTTSGWGSPAVLVPLIISVFLVGGFFYFETTIPADRAAIPPRTWFLPNFLVLFFTALLPFFWWTTIFTVYTTVWQDVWKWSAISTAIHMIPIGVLSFSMSFTGPLSRMIDSKWIILFGEGLCIVATILFAFADSPERYWPYIFPAFVLGSAGAMLAYTHTNIAIFRTSPSSMAGTVGAIFNGALQLGSAVGISAVGSIKSSVEDTHGGPSSYAGCAAAYWFLLGVVGVEFVGLLVFYKPDIEGTTEDEVLQKSKTLADVEDVVIQEKVADEGGDEGERKDEVQEQEMDVSDMSARPTQGDDNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="TBU62762.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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                <person name="Ng V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
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    </evidence>
    <sequence length="81" mass="8497" checksum="A6236A1D171CFA8B" modified="2019-07-31" version="1">MVPKSTVLSQLAPRALHSQRRQCDPFIGLSKHHPIASLHPPFVPNAGSVNTSSGDAIEPHRKGAPSTQTLHIAQSSTGLGA</sequence>
</entry>
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                <person name="Makela M.R."/>
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            </authorList>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="TBU65222.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="654" mass="72059" checksum="A29878006B39F0FA" modified="2019-07-31" version="1">MSSYLQQLDHLANRIAQYNDPRKHDPYLDLLKEVAAVVREADTRGAPNLTEIVEKAGAIYDSAINWAYGDGDFDFLPSYAHTPDAPPIKDPLHRFGFGAGPAIELLRIIDSMRVNGAGPLSATQREEFVPPPWTKSQPPHPKSTRLSRFRDNVRPSATDATPLARTIYQARCEVASDSIPCPVNAAIASDSSVLAIAGKGGWKNRDPVLSLYLLDEGSAEQGGGPAGARSSQSLDWRCMNIDPGLSEVAYQIALDTPRKLALVADSHRIKSFCWGQSGGVEFEGWSPTQGNNVHTLDSDRYRGPLAVLPNGRVVRAGKGGFALWNIDELPTHKGGRRVGRGKYSDDSWRDNDNGEIERSTGTTPTTTVKFAGAGDETFAPDSWHLHDPSGHMLVGENGRDSAGRYGCYAIDLEQGGRKVARYLGHGGNAIEGFSTSAGDANVFATAGADGYARLYDVRHPLPVITIDSGKLSEFCTSVQLVHPDGIPTLFTGGDKSQSVRCWDIRAQAVVYELSTGNNSVCTLSWDAKRDVLYATTECDYMDRLGSTHGYRHARIPRWAQLCPEDHERENDGLEEEDVDMQDDEEYDGDEYDSMEDDDDENNWPKDAYHNETFFGYAYDAGEHVLLRYAFKEDPDLQELPEYGQASLDYDDGYW</sequence>
</entry>
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    <name>A0A4Q9NXM3_9APHY</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Riley R."/>
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                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17710" checksum="DC4FC13FD3D75984" modified="2019-07-31" version="1" fragment="single">LSTDELSNTSRFLSSGSSVVQSPALPWEVIERVIDLCSNDKTALRGVALTCIQLYPRSRFVLFTNVKLRSANQLMKFYDAVQAQPHLQPVVQSLSFPWGIVPSPQLLSILPGLHHVTFNKISSAIGQLPQSALHSGLRSLTIRDARFQSPAAFFRFLSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3M1</accession>
    <name>A0A4Q9P3M1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nucleoporin NSP1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Nuclear pore protein NSP1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoskeletal-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_927190</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Nucleoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3M1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3M1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000040">
        <property type="entry name" value="Nuclear pore glycoprotein p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="16">
        <location>
            <begin position="457"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="185"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="254"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="352"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="521"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="263"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="424"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU58381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="683" mass="66073" checksum="D10E797A48342526" modified="2019-07-31" version="1">MSFFGQGNNSSTTGNTTGSGFFGQPPAGQAGQTGTTGGSLFGGSSVFGGANTTGSLFGATNNSTNTTAPGGGLFGQTNTTAPATGGSLFGSTAPASNTPASGGGLFGASSANSATPAAGGGLFGSTNTSATPAAGSTTGGLFGGGGTTGTSLFGNNASSGTSGTSATGATGNSLFGGGSTGAGLFGAKPANPAPSSTAPAAGTTGTPSLFGNTTGSAPSSGLFGSTGTTGSTTTPAASGGSLFGNAAPSGGFFGNKPAAQMGTTTTPAAPSGGLFGTSAAGASTGTTGSTTAPAAPSNSLFGLPPKPADPQGTTAATAAGTAGTTGTTGTTSAASSGNLFSGSLFGAKPATPAAGATGATGTTSAPTGSTTTGTTGATTTPSLFSLGGNKPDEKKDEKKDGAAAPAPVSSFNLFGSKPDDKKPSSTPASGASTTTAPTLGITTATGTAGGSMSNATTTTAVAPPSALRGKNVEEIVNKWSQDLETHVREFNKFASEVHVWDRALIENGNNIQRLYTIVLAAEREQNDIDQSLDHIEQQQKDLAATLDAYEKSTEEILGGQGGNLRALDTGPADTERDKNYMLATELHGHLDDLSGSLMQMIESVNALSLPSSGANGQGQDGADDPMGQIAQILSSHLESLQWIDGAVRELDTKITDIERGVKARTGGGSLLGSSTKSRGYGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4P3</accession>
    <name>A0A4Q9P4P3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_806194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4P3"/>
    <dbReference type="STRING" id="114155.A0A4Q9P4P3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103:SF5">
        <property type="entry name" value="DNA-BINDING PROTEIN HEXBP-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="114" mass="13188" checksum="D70C28FA3A60977D" modified="2019-07-31" version="1">MLILSIVEHLPSKCTLAHRVCFQCREPGHESKACPKRFQDRTCGGCGQKGHISNVCSSRESWICKNCEEWGHGHWEYTKPQGYRRLRCQWCLRLGHSTFECVNEPILVRRIGCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P512</accession>
    <name>A0A4Q9P512_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_925623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P512"/>
    <dbReference type="STRING" id="114155.A0A4Q9P512"/>
    <dbReference type="OMA" id="WVAEIDE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="188"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="451" mass="50478" checksum="80808BD4697DC233" modified="2019-07-31" version="1">MESRLAQLAPLNQKDKAAGYQALLTELLTRQDQTGLDRDVHLLVENVLQESVGLVIGRLVLTELVKALSEGKIKETQLRKTIVKDVLELIQPRIVTYEEQVNTLRFQLADIYEEDEEWSEAARVLMGISLDSGQRALPDAEKLRVYVRIVRLLLEDEDSVQAERFYNRAALIAHTSTDKETLLSFKLCQARISDYSRKFLEAASRYHELSWIPEIDEEERKHMLSAAMTCAILAPAGPNRSRVLASLCRDERTQELPSFRIMEKMFRDRILRSNEIKDFEGTLKPHQLAQIEISSNDRLASIVAADDDEANDPIISTRKGPSTVLDRAVMEHNLLASSKVYNNITFRGLGTLLDLTPGAAETMARKMIEQGRLKGTIDQVEKLISFDVGGEDDGAQGKAGGLGDVEQVEEDTGASFTKRWDMQIRLTGANVEAIVQHLTETGLVSFGTVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P771</accession>
    <name>A0A4Q9P771_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_948240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P771"/>
    <dbReference type="STRING" id="114155.A0A4Q9P771"/>
    <dbReference type="OMA" id="FKMSVQH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21377">
        <property type="entry name" value="CTWD_Cns1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047861">
        <property type="entry name" value="Ribosomal_eS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00948">
        <property type="entry name" value="RIBOSOMAL_S7E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="547" mass="62171" checksum="C2AD7E79DAA11A4D" modified="2019-07-31" version="1">MATEEKLPLPQPAPIEDKLAAFNTVPLFMRSLPEDGAEDPAIAALQSLAYEGTPDEVAQNFKEQGNDYYKGKRYREALGFYTQGVDAKPTDKSLLEALLCNRAACNLELQNYGSVLRDCSRAIEVNIQSSKAYYRSAMALIALERYDEALDACDRCLQFDKDNRTVQAARDKAAKLKETKERKERERQERLRQEQLNKERLRAAYQERNIIDAPVPDNVAKTSYEPHFDPEDPSNNTMIFPVLFMYPQYATSDLISHFQEDTPFSAHLSVMFPAGAPPPEWDKKGEYVDGNLVVFGWTKRRRLLKIGKKMTLRDVCKAAKAKEGEPGDGLEMRDGTLTFVVLPKGTEEQKWMSVQHKIFRTANAPKTAPDETETAVAQAIIDLENSAPELKAELRPLQISAAREVDVRGGKKAIVIFVPVPQLKAFHKVQQRLTRELEKKFSDRHVVFVAQRRMLRKPTRNSRVQQKRPRSRTLTSVHDKILEDLVFPTEIVGKRTRVAVDGSKLLKVFLDSKDATSLEYKLDSFSSVYRRLTGKDVVFEFPVQAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9D4</accession>
    <name>A0A4Q9P9D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_770539</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145353">
        <property type="protein sequence ID" value="TBU51250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9D4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8329" checksum="6472D7F4BA327F71" modified="2019-07-31" version="1" fragment="single">MSYLPQPLTGSILGPAFEHKHQSPITPPPVLDSETEQESAMDFLHDYHDQHDDHAEAERDALGHGSDIPDESIVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9E1</accession>
    <name>A0A4Q9P9E1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_982815</name>
        <name evidence="2" type="ORF">BD310DRAFT_982835</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145368">
        <property type="protein sequence ID" value="TBU51183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145363">
        <property type="protein sequence ID" value="TBU51204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9E1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="433" mass="49790" checksum="4858BF392CD47CD3" modified="2019-07-31" version="1">MAPRVIADSHFHGSEKRSPLATLRDVARFLPRQYTPYDNFNSMFVTGMNIWQLGPMSEADRTKRIRGVRKLAFKDAEYFAAMFEDLIQEHAIFRNYAEKLKGRPQDILNMGRFIDFHARAARTSDIRTLKVELPKFFEDVPVSPDWHIVALSAVEYENRERNCGLYSDCTARLLVNINEREQFDRNGTIFRMNKLAETPEQKKKRLRKHPETDENHSYPSFLFPAQLQYDPTNPSNGLFKGAFFRKVRFLLSAKREWDGDDADGSGQLLHSALREFLDLEFEAHEDAAEEGRYPPGSEKEELTENVFAYFNRWTFGRAYGDDQIRLKQIQQKNRSLYDEDNTGDNNHGARTIRAQALAAHKARLQQIATRRLEQQDDVDRSDGFSYGNHVSQTTSRAATEEVPDPIQVAQAHEDASMPDQTPDMQGPTSSANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9Q9</accession>
    <name>A0A4Q9P9Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_692896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9Q9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14515" checksum="9EF78128D3498B0D" modified="2019-07-31" version="1">MWTQRTAESCIDVSLAGPRPRAHGIALVNVICRRLVRSCQHLDALNKPGSPERTRSNEESAGRNASSPLSSKTRSSIRPPGVPPCSCCNPVHSHADERIPTTMCSEHMPCSLEASVSWSSSMSWPSGSCELRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAB2</accession>
    <name>A0A4Q9PAB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_912835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAB2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAB2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="4"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="354"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="480"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="613"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="706"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="480"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="619"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU66129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="757" mass="83652" checksum="CCF0CAC161DE3AA6" modified="2019-07-31" version="1">MTTLKIAHFNDVYRVQPFKLHPKSPETIDVTQWAALLDDVRDQWPLREDGKRDGLVLFSGDVFSPSVESSVTRGSHMVPVMNAIAPDISLTGNHDFDFGYPHLSKLIKDTNFPWLLSNIIDTETSRVPEGLLEFYVFERAGIRIGIIGLVEKEWIATVSTWPSNFKYKDMAEVAIDLSKRLRDPEGEHKCEVVIALTHARVPNDVVLAKAINALSPSAQETNPIHNLHGADIIFGGHDHLYYISKGVTSWENYDVNQEVLGGEQDHGDVLVVKSGTDFRDLSELTLELADTPEGSVRRKVIKVIKGKHHETKPDCRKNEHVAELLKDLLSSVSSALKAPVCKSAVELDLRSSLIRVQETAAANWFADVLRHAYDDALCLQTGGGADGVFICAGTLRGDSVYGPGPITLGDILEILPFEDPIVVLELDGETIWAALEASLETWPAQEGRFPVISGFRVSWDSRRPPGQRVLSVWLLQEQPSGSTSNSGATTPTSPAHSGYVSPERRGSASSSMTSLLQNTATQSTVTLVDGEPIQRTKGGKMYKIVTREYMAQGHDGFIPLKGKKYLVDDESGQLMSAIVRKYLLGCRFVNRLSRMASMHSLQLLDPETPAVISRERARQSHASRRSRSKSKDRLSGARAKSPVGALKDASSPRSLSPGRAIGDLWRRAAGIALRWSRGHYRDHMRISGREHMSEVDCFDGETMRKGKFEKDRTERGSQETEEKGKGGEENAELTGSEEDLATIHPVVDGRLKDEGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAJ3</accession>
    <name>A0A4Q9PAJ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_836422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAJ3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAJ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF488">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="159"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="674" mass="72472" checksum="D9AEE65FAB7D28FF" modified="2019-07-31" version="1">MATSHSLSSPTSHRTVAQLPFSPSNNAPRLPGINTGVSASATPSGNSPTATSPTRWTAHDRTGSVVSSRPRAQTNMSHVASELPFVPSASMPIIQPRPTTGTTHGTTHVGGILPSASFFHPSRPNHVPLSVTPPLPRPSTVGSLASIGGSTVDAVRLSQLGGSQHRDRTSEGSGSADHSIEDAKAPTIAPSLSSNKFSREPLLPISGAPKPNGATRPTIVTQTNPYGRSDSNLSAGARMRGSFEKLFKRPFSFDRSPTTPNNNPGPSSAFNHFQTGSTQVSPITFELGANGAGVEGSPTSPGHRKHSLSPLQGSTTSINHASFIPSPPHMDPPLCETPILDEKTGKPMRRYQLHPSRNRFLLGGRILTGGDSPWAFIGALTLVLTIAGVYFGTTCVWWWNNESPAVAAVGAYMCLLTISSMFATAFRDPGILPRNLDPEPPYPASSSSDGSLRQPLPRDLKVRAGIVRTKYCPTCMTYRPPRSSHCKMCDNCVDGCDHHCQWVNNCVGRRNYTVFFTFLFSGVMTLVLVITTTALHLYLVAHKFHLGFRHAIATSEGIGSAIAFSLSILVIWPVMALLSYHLRLLLLNVTTIEQIRNQAHKTLLPEGPAPPNPFSHGSWRKNLVYMLCRPTGYSWLDARAVATEDKREVNPGLLHEHDGWPGDVEHGPGRGKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCH7</accession>
    <name>A0A4Q9PCH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_833696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145290">
        <property type="protein sequence ID" value="TBU51735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCH7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF284">
        <property type="entry name" value="EG:103B4.3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="213"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU51735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="43244" checksum="1FEE6AED69C2817C" modified="2019-07-31" version="1">MLDVPPDGGRGWVVVLGCVIFSAATVGWGYVFRTILPDPCFSIAPVVLTTHQVWGVTEEYLKNHVFPDASDSVLSTLGSPFLAAGAIIWTISMLACIFATKLWHFFVIMGPVQGIANALVFPLIVALPAQWFLRHRALATGIVVAGSSIGGAVSSLIFGVMLNSLGLKKSFAIYTAMDGALFVAAYFMISERRKPSQRKPIVWFDKSFFTDPVFWSLGGCFFFTVFGYLSPVFFLPTFAQEKLPNLSPLLSILPVAMLNFSAATGRTLVGLLGDRIGPVNALWSAIMLSGLIQMLVWSFVSTYAGIMVFGIMYGFVCGCFLSLSPAVASQLYGSSRLAGLSGLLLMFNLPGNSAGAPIGGAILSATGGNWLAVSLYSGSLQIIGATVLLYARFKREPKIFTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDD8</accession>
    <name>A0A4Q9PDD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GMC oxidoreductase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_1007674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145351">
        <property type="protein sequence ID" value="TBU51257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDD8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDD8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU51257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="36397" checksum="BA6CB50A5F6BC8FF" modified="2019-07-31" version="1" fragment="single">ENTVTKLISTGTVKGAPSFRTVQFAPNATAPYSLVTARNEVILSAGAVGTPQILLLSGIGDKDQLRALHIEPLLDLPDVGQHLKDHPILANYWNVSSNNTYDDLIRNTTLIEAAIAQWQTNRTGRLVDSPVQSLAFMRVPANSRIFDNVTDPSAGPHSGHFEFLFADGYGAVSVPQPPTGHFLTVFSAVVAPTSVGSIKLASSDPFDNPLIDPGFFSTEFDVQVMLEAIKTARKFMALPAWDGLVSGRFGPVGDAEKDEEIIAAARASVETIYHPVSTARMSPRDATWGVVDPNLLVKGASGLRVVDASVFPTIPAAHTMALVYIVAERAAELIKRAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE61</accession>
    <name>A0A4Q9PE61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145224">
        <property type="protein sequence ID" value="TBU53139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="681" mass="77256" checksum="136D55778CE6750B" modified="2019-07-31" version="1">MPFGPHTDPQIFESLNDLALIGCKTDILPNIDAVRGRLTSLVETPATEAKRFHYTVAHILFAVMVLRKYLFYYIWEGSIVQYSIPTVTIMVVLQVKSQVSKRFQRLLVSLHRYRNALVPINTLPDDVMLDIFREAAPRDVGHKHSILRTCTRWRHLSLSNTAFLTTLKLPEDPRELGPILDAARQLVPEPSLHLTIDWEDVRPSLVRSLRSTLSDNKSTMTKMTVSNLPRLYSQDWDSDSEDYDGSDAESEDLGELEELSLLEEFVPSLRALELRRSGQGLLRARDDCILPNVFGESGDKRLEVLILVNCRFPYTPRCYSGIRTLHIEFDSPPMRRRKKDRQWDGQFIDVLLTCPHLEHLVLRHVPMSLEEAIAHRPLFSVPLMNLRILRVDLDVQRVGGLLRGINTSAENLRVVDITLGDLNCCNTFNQSWTQAILRATLAPFSRFTLESLPVLKQLELLTMLRGMAVHGRGPLRRDPSGMHTASPRFDLRLTLPSDGSERDSMDSDISGGPTVSSDDGTMSIDSAVDNESPMNVAFDRFTDFLSQCSLHNVRTMRLYLFTPDMTLKVLRATPRIQELTLDDPTIMVEIASASAKAHTYRSMCPRLETITLERCTLRGDQLSAICRAAGVLELRTLTLAQCDSELEPMNVLRGLGRHGLNVRWLEDLPTDELCRDQFQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG96</accession>
    <name>A0A4Q9PG96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_830227</name>
        <name evidence="12" type="ORF">BD311DRAFT_802608</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPP phosphatase family. PP-1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145216">
        <property type="protein sequence ID" value="TBU53365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG96"/>
    <dbReference type="STRING" id="114155.A0A4Q9PG96"/>
    <dbReference type="OMA" id="EEHEIRY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000007">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="11">
        <location>
            <begin position="122"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU34250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU53365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="38153" checksum="F04C81E1FE0E1C9F" modified="2019-07-31" version="1">MADTTTEIDLDSVIDRLLEVRGNRPGKPVQLQEYEIKYLCTKAREIFINQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFVLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLQSMEQIRRVMRPTDVPDTGLLCDLLWSDPDKDITGWSENDRGVSFTFGPDVVSRFLQKHDMDLICRAHQVVEDGYEFFAKRHLVTLFSAPNYCGEFDNAGAMMSVDETLLCSFQILKPAEKKAKYPYGGVNMGRPVTPPRKQKKKDANKMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGI8</accession>
    <name>A0A4Q9PGI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941932</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145302">
        <property type="protein sequence ID" value="TBU51616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGI8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13233" checksum="06DDB135537145C8" modified="2019-07-31" version="1" fragment="single">MRRSSAAMLVASVSCPTCYVTCVRVPMRHGVGLHMLLSPAWFVAIQILYARLQGPWSLHSFPPALRVCASMMRWGSEMCLTPGPRKSAAVTSSNGSGFLSISVSRVLALVNCLTPGVISPSPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH98</accession>
    <name>A0A4Q9PH98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_932170</name>
        <name evidence="2" type="ORF">BD310DRAFT_934955</name>
        <name evidence="1" type="ORF">BD310DRAFT_938871</name>
    </gene>
    <organism evidence="1 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145228">
        <property type="protein sequence ID" value="TBU53007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH98"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6336" checksum="074641A982604934" modified="2019-07-31" version="1" fragment="single">MALLQACRFSTFIRIAGLQIPSTLKCPIRPKTLLSESLAVSLGNLLLALARRPGIKCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIW5</accession>
    <name>A0A4Q9PIW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_936960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU54006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIW5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIW5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06168">
        <property type="entry name" value="LSMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034110">
        <property type="entry name" value="LSMD1_Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF5">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 38, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="2">
        <location>
            <begin position="23"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12918" checksum="D4964BE28DA780BE" modified="2019-07-31" version="1">MSSPPIATAMPSTRSTPPTENVERLQALLRKTLRVSVTDGRVFLGTFAGTDKQLNILLINTDEYRLGPDAGSDGLDGRYVGQVMIPWRLVVRVETNAEGEHTRSSSYRDSDEDSMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJB0</accession>
    <name>A0A4Q9PJB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_886577</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMP46 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJB0"/>
    <dbReference type="OMA" id="PNALKWP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006660">
        <property type="entry name" value="Arsenate_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012882">
        <property type="entry name" value="Fmp46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28071:SF1">
        <property type="entry name" value="REDOX PROTEIN FMP46, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07955">
        <property type="entry name" value="DUF1687"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51353">
        <property type="entry name" value="ARSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU54180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16761" checksum="0959450A705E3FD1" modified="2019-07-31" version="1">MFKAFTRSIPEISIFHNPSSPASAKALSLLRSALSSPYPPSKPSAPPLNFNLEVIENKPPTKDQLRTILSYVPAKSPSGTGGIAPAPSAETLLSSHPTVDERPHDVEGVATLANRNPNALKWPIVVDWHNGRASIGDVGGVQQILEELRRKRDGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJP3</accession>
    <name>A0A4Q9PJP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_828354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145192">
        <property type="protein sequence ID" value="TBU54306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJP3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20033" checksum="699D318F13D75272" modified="2019-07-31" version="1">MSYENEKALPPGSLHDSLPEDSIPKLDGEIEQELEAEEDAHIGVKAVRESVWPPFQVVPFHWTTYNYLAFATSAFDKHSLISTIQVAQSVIIACGKPVIAKFADVTSRATAYLIVLCFYVLGHIVIASANGVGALAVGIILYAVTITEVNEESSRKKTVFENVGLCLEGRDVFKDDGTKELYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK46</accession>
    <name>A0A4Q9PK46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_935874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK46"/>
    <dbReference type="STRING" id="114155.A0A4Q9PK46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU54482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="154" mass="17366" checksum="37993352CBD1AF90" modified="2019-07-31" version="1">MSLTFFTEPFYSLSDFDRLFDEAFNARTSNAVSQRGQNENAASRPLRPRMDLHEDKEKNLVTAQFELPGLTKDKVSIDLRDNVLTISGESSISSEHDEKGYAVRERRYGKFSRALPVPQGIKPEEIKATMENGVLSVTFPRTTPEQAPKKITIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKB8</accession>
    <name>A0A4Q9PKB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_1041711</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKB8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKB8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022702">
        <property type="entry name" value="Cytosine_MeTrfase1_RFD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00675">
        <property type="entry name" value="dcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF52">
        <property type="entry name" value="DNA (CYTOSINE-5)-METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12047">
        <property type="entry name" value="DNMT1-RFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 9 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="435"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="607"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU54545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1248" mass="141675" checksum="31E41B461B44A5B2" modified="2019-07-31" version="1">MSRRRHTAFTLSFPEENVASASSPSLLVQPQDPTPVPIPSSASYRAAKRRRTDAPAAEHVDKRLRRDAVLENRVGGPPVRKLSYQPHPDEIQENEDTIVQGEDADDYLDEEAKPVRILSDFAIFDPRHGRGFELVSLELLHVTAGTDHHFEAAGNVSPVYLNEEDAGQEDIVDNSKKADLQRLRTSTIFRYFIDYQAVDDPLYVETQYGWYILKSPTVLYRNIHRRFYTPHRIAQIVISVALEGLVTTYAEFAELYLGRWDDLLNDHVQTEDLARSVALVKSILDDDTALRTKVTSRPFVQHIFDTLDKKHTPYPVHHMILPADSRASRPRPFFQPNKVTGNLDLAVLRPENQNPTHVTPLIDTLALGLFREHLKVVGAAPKRLTGHELRQRQLKVRGRIGDLLMRRIDNRSTIDFPQEERLDGQYWKAVKIGQEVYKLGDCVIVLAGEHKHRPAPNIPQDLNEVPEHASVGEYFWFARIVYIDQREKTAHVQYYEHSSKTYLEEISNPQELFLCPQYCGTIALRDVLGKAVVCNDYRPGEGEDFDPLHFFCRFMYDDLDGSFKDVDTSDGDALDPPDNCPACLLSTQRQSDLVPTIIRGGMTYLGSTYHHDDYALISNAKQKKVPALVGMVIRIRPKRQDDKIEGTIVVTVKLLGRIADLLSEPSFAAPADAFAHERELFMTGLEMDVSGNDLIKRCSVLHHSSRTHMDAWLTRSPYHFFVRYSSQTLEPKTWNGLTELSRKKVPVCQVCFQEDEVRTQQLKAFTRQQPRACLRGFDPFAGVGAFGLPMEATGCIKITHAIEISPSAAATMQKNSPHTTVYNQCSNIVLRYAVKSRAKQWEGPPPLDIQGKAPLPDPPKPGEIDCIVAGFPCQPHSTLNMFQKANDRKSHLLLNLLSWIDYLQPKYCVFENVRGFLNYNLNASQAGRYRMVGGIKMGGLKFFINALLTLGYQVHFSLLQAGQYGTPQRRVRFFLLASRKSYPLPSFPLPTHAVLNPDALSIRFPNGVEIKPIITGGGTAPFRAVCIRDAIDDLVAFDWKDPGKNGMKARKGVLSIECDPKKPYCGPLGDYARPPRNSYQKACRTKPATELQHYTRTFKHAVVSRITNVPLTSRADYRYLPDEHSEWQFRNPASATARLGFRPGMYGRLDEKDWFHTTVTNVDPTAKQSYVLHPKYRRIFTIRELARSQGFPDWFTFVAHGDRMKTLHRQIGNAVPWQVGEALGRELERAMFEKWKQDRDGAIQIDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKZ6</accession>
    <name>A0A4Q9PKZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_763244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKZ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="299" mass="33987" checksum="13EC51E920BC4E90" modified="2019-07-31" version="1" fragment="single">LSSFLDASTITSVHYDEVRRRLQLYGLSPTEYTSTPYGIRTQLPVLPLSAILHPDETKVPDDHPMSHWYLAILGCEHGDHPGHLLGRVCRIPPSESGVDLLYAGWIRVVREGRYLGFFEGPDMLALSPATVERCRSQIVVRTVYISHPARRYRDPEEKDPDDDRPHGSIFLRLSRETRDALCAQQYTTSLRRPDQAHPTTHRLTLSHHDHTVSIEYDHTLEDGGKRLTMRARVEVSGGLGPSPRDVLSTQSPSEVSWSDTPPWFTTRRDREVTVRAGEKEFTVTLGLTFLRPSWYAIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM04</accession>
    <name>A0A4Q9PM04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1041250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145172">
        <property type="protein sequence ID" value="TBU55250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM04"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="223" mass="25240" checksum="EC9E2FCB00012BE8" modified="2019-07-31" version="1">MSYTLLSGEDTIHTAHHDLESFYWTLLWIALRYTGHDYKPNPWQPDPCARAYRIGNDEEAASAKAHWIIGRKLRITFTGNKPLTDLMHDFRMLIWQRTVAHPYEQEPQYLTHAAVLELLDKALARSNEWPDAKSEGSKAFVRPHTVSVHLDQPKRHAEQDAEDSESTAKRSRRQSKKENGTATGDPFESTSNPQLTTVKGSSRGSRGRAGGDSKTRGSEKQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM50</accession>
    <name>A0A4Q9PM50_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_950859</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM50"/>
    <dbReference type="STRING" id="114155.A0A4Q9PM50"/>
    <dbReference type="OMA" id="EGRLWIC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="13">
        <location>
            <begin position="18"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU55303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="254" mass="29140" checksum="EA17550E9355FBBD" modified="2019-07-31" version="1">MSPAPSATTPGPHSVLPPNGLRIRKIRFGEFDIDTWYDAPFPEEYAAIPDGRLWMCEFCLKYMKSRFSASRHQLKCKVRHPPGDEIYRDGKISIFEVDGRKNKIYCQHLCLLSKMFLDHKSLFYDVEPFLFYVMTETDEDGAHFVGYFSKEKLSPKNYNVSCIMTLPVRQRQGWGNLLIDFSYLLSKKEQRAGSPEKPLSALGALGYRNYWTLSLMRYLQNAPANPRLEGASVSCRCCQICNQFLLQTSAPLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMU6</accession>
    <name>A0A4Q9PMU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_933435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMU6"/>
    <dbReference type="OMA" id="WIDIFRC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44540" checksum="CA9A8EF2B7AA7075" modified="2019-07-31" version="1">MTSLPDLPPELYDCVLDCLSDDKPTLRRCALASRQWLPRVQHHLFRSIYIDWSNCYAFTRLLQSNPALGLHVATLEIEGAFGIFSMDRLHGATLDAWLRSIPPSFPPQLSNLTKLELALITIDAELVRRFFGRLSGISHLTLWACALTSFDVFVELFASFPDLKRLSIAFTQEWETGPRPIAAFPEGVILPRIEVVDMTSCCDNFKVLQWLVAQNLHTAIHTFSCSRVPWSSICVLRNVLGALAPTLRTLKVGFGDNGAMSDDFPSASSSWAQNAFSPLAALTTVTLEIQTGRIAVVPFTLLLLVHLPVPALRTLTFAVKCGEYDSALGELWPRMAATTASVARATPLERVVVCAKEKSEDGVASGASFPYRGLPSFDFAEMESAVVAAFAAKGLEKMLTFVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPK0</accession>
    <name>A0A4Q9PPK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_766616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPK0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13423" checksum="0FB18DEAD3C677E4" modified="2019-07-31" version="1" fragment="single">MQQFLNILGRTAQLGAYIAEAPDQEWSPRRALSYVVENLEMEGVHTPATWLHNHALDPEASTPEWASRMLEAYPTRRTRIVEESTTDQQAGQQLQPPPPEPANQQYAQPSVAEVADESPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPN5</accession>
    <name>A0A4Q9PPN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_823998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPN5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="249" mass="26965" checksum="15DE6014268A07BB" modified="2019-07-31" version="1">MAPSDGGFSPLTAAWIATTSLTVNVLIGDAIVWWRACVLWRSRLMYCLGPAILIIGLALELLGATIQAKTESQVVSYIPDIMGAHPYGAIVTGLSLIINLLATSLIGIKAWRHRASLQGHFADNTGRQYVLKVLALLVETGVVYSATLIVSTVYLAVNQVSSRPGRAFSNGYEVFTFGCIVPMIAIYQMLIIFVIALDRSQLEHTIQQDDDSNVTLTQVTGAVSVTESTEWGSGYTVDRSTSRGWGKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQB7</accession>
    <name>A0A4Q9PQB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_854872</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQB7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043658059" description="beta-glucosidase" evidence="16">
        <location>
            <begin position="22"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="18">
        <location>
            <begin position="119"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="17">
        <location>
            <begin position="274"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="19">
        <location>
            <begin position="683"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="458"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU56539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="898" mass="99244" checksum="895052658299FDA6" modified="2019-07-31" version="1">MYPRTALKFALLAQLAFLASATYSDPKVLDACPGYKAKNVLDLGHKLTADLVLAGTACNVFGNDTEKLKLEVTYESQDRIHVKITDPTENRYEVPQEVLPRPSANLFAGPLTSNIRFNYTTSPFSFSIYRSKTHEVLFSTASHPIIFEPQYLRVKTNLPANANIYGLGEHTDTFRLPTHNYTRTLWSRDAYGVPHGENLYGNHPIYYEHRTTGTHGVFLANSNGMDIKLNDTEGTGTTLEYNVIGGVLDFYFLAGSESDPTEVARQYAEIVGNPAEVPYWSFGLHQCRFGYQNYIDVSEVITNYSAAGIPLETMWTDIDYMDRRRIFTVDPDYFPLDRMREIVDYLHSHDQKFVLMTDPAVAYAPGESYGPFDRGTTADIWLKAANGSSPFLGAVWPGVTVFPDWFNPKTQDYWTNEFQSFYSPDTGLDIDGAWIDMNEPSSFCNYPCTDPFEQAREQALPPARTSPPPDPDAPIFGEAPPSKRKRASAPDHSGDNVQSPPYAIANFAGAGPLSDKTAYTDAVHANGLIEYDTHNLYGTMMSTATHEAMLARRPGLRTLVITRSTFAGAGAKVGKWLGDNFSDWDHYKQSIAGILGMAGVYHVPMVGADICGYAENTTETLCARWALLGAFYPFMRNHNADTSISQEFYRWPLTTQAAKNALDVRYRLIDYLYTAFHQAKTDGTPVLRPLWYAFPKDTNTFGIDTQFLFGPSVLVSPVIDENSTTVDVYYPKEFFYNFHTLAPITGVGSSVQLTNVNFTTIPVSIKGGAVLPLRASSQLTTTELRKTDFEIVVAPALADGSASGSLYLDDGISITPKTSTSVSFAYNRGKLTVKGSFGYATGVNVSRVRFANTKSAPKSVKFNGKAVSADKVAFDSANGVLDVTLGIPFKSNFIVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQT6</accession>
    <name>A0A4Q9PQT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_930937</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQT6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQT6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="11">
        <location>
            <begin position="171"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="336" mass="37714" checksum="8C44CFB2D37165CE" modified="2019-07-31" version="1">MPLVFPSPPISLSTAHAFTAFFTFSYVGSLYATKNARLSFKTGVSHNVRDGEERAKDSDERWRNDPEVIRARLLAASLSTLGSVLAVYLLVQGITPAAEKSKNPTVALESTLARLGITLTFARNSDLYIISPCLVAPVLYLGPLYAAYLSERLPYQRRWSFSEDFLPTFTSLIGIRNYVVGPVTEEVVFRACVLAVYHMAGASRNKMIFLSPLVFGFAHLHHAWDTYNRYGRTASALRIAALQTLFQLAYTSLFGFHCAFLFLRTGSLLPPTVSHIFCNVMGLPQYGFHVRMLPNRRRAIQIAYLIGIAGYVYTMRWWTRADDSLFWPAIGEPGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR22</accession>
    <name>A0A4Q9PR22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_601572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8451" checksum="BD70ECFBEA8B2A1B" modified="2019-07-31" version="1">MVSIPLTWIAAAPASYLRLQTAQPPSVFFCAFLRSPDPPTERSMPGIHLLWRGAHVRSPRFHEATKRRVSAPPSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR66</accession>
    <name>A0A4Q9PR66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_930687</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR66"/>
    <dbReference type="STRING" id="114155.A0A4Q9PR66"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU56872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="459" mass="50599" checksum="CA294CAD34B44CA9" modified="2019-07-31" version="1">MSTAKIPVIIDTDPGVDDILALLLALASPEIEVLAIIISFGNTDAEASYVNVLKTYQAIHRQLEQFPQDAYRYVNFSQERKTILAVGEDGPLEGALHSAKYFHGRDGLGGITQSHPDLNVDDNHPSQHPQLELSSKPGVEVALDLIKSEPERTISYIALGPLTNLAKILRLDREAVRDRIGRVVCMGGALDVPGNHNPVSEFNVFADPFAVKELLTPDDFEQGLPLNRFLLLPLDITTPHEIRFPYYKEMVDPAFESTAFPSHPEGKPPIVHFTSSFFERTREVMRQFGKDAMELHDIAAVWCAIENPPVRDEDPDPAALPVLQQGWKAMRRKFGVERLGELTRGMFVIDRREDPSAYAPGANRAKVQAELDRLNFQHAGVYESTAVPAEVEVETPPVFKDRSHVHAQVSTGATATDTLNRPSDGQMNGVAGGVPCITRTPGSAALVKLLLERVWGVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRA4</accession>
    <name>A0A4Q9PRA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_959938</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="497"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="887" mass="94450" checksum="86A10210B8867F76" modified="2019-07-31" version="1">MSSHCRPGPRAITPFLLGSPLASPRPVSDAAGHHHQSETEPEPAPEPEPEAAKSPTETQDPRSPAHPSAHLSRSLSARSARLSSSLLPALRLAGLAPDPDRDRVRDRARDRSSRDMRSSSSRSSKDTHTKPRPIVVLKLSGSSFLDTVIRDDKSKDPIYILETTAENTHIFRLDHPRDDAVKAATVQWPAHPVRVKGKSGRSIQFGNGSWREAEDVLKSGPLGNTAIRKFNLPHYPNSLKWKLIPGNCFCCVTNAVKGPVAVLDAATLSAPPRIKIYDSLIDKETARSQDNYKGVPTILLDYLVTTALLLVTDVQEWLDRPREARIPGSNSYTIQRWLALIHHTPAPPEPDHPTVDLSLTVPSTPPHSATFPSPGGGWDAQSRVTSMSGSNGSGSGASYIGDPFTPTTPATPATPATSAHSSMLFSQPGEDVPPVPPMPASSSSSPFVFNVNEPRPRQRPKSNPQTSSSHSPTSSTSTAQATRLPNPLTMPISVPGASSLLSQSAPVSASAPTSPYPTSAGPSTASSSSSGSRLGRRQLPTPPAPAPPNSFAQPWLYHSSSSSSSASASTATPAPTSSLPSPPPGTPTTSAGASVNTPSRTAARVSMRGTLRTAAIPPPPPPPSGSIPLPPKLAQEQRGYASPRPRTAPDLQDGNRRRHSAGEFGARGYAREHAPYAQAYTPLRGRDVDEREELAAQMRGLSVGPSTSTAPMGHGHVRAPSQPAPDYDTHSFVNMPPPVPALSPLPIPHSAGGSGMRSPPGGSGRRVLTVVNGDASSLPAEDPGLLLHSERERERRIRQQQQQQQQQQQQQQQQARMSYADSVYEMPPPAYDAIDFSVPPVPPLPRQQQPQQATQMQQLSIPQMAPVPSTPLPRTPVEERGEGPRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRE7</accession>
    <name>A0A4Q9PRE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_978459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRE7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6336" checksum="605A9E611D91DC6D" modified="2019-07-31" version="1">MLIEMEGQVLRRLNASGVQHVAVLICDGDVRDHATITTACIGILFRFDHARQLFVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRJ2</accession>
    <name>A0A4Q9PRJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_881703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRJ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14464" checksum="A0316070E09EDCA9" modified="2019-07-31" version="1">MSRQVGGQDQRTFAGTLLRDGTSYFLTLLILNVLHIIFTSTSVAESGLGTQSVIPRLEEPLTSILTARFLINLQKVHRKLAASSRSLSQMSDVAFQPHVAENIHGFVGSLGSQLSFGEDDVEDDMVGDDIDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRY9</accession>
    <name>A0A4Q9PRY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thymidylate synthase</fullName>
            <ecNumber evidence="2">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_881460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.45" evidence="2"/>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRY9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRY9"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate synthase/dCMP hydroxymethylase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU57166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="305" mass="34534" checksum="B81C1E2AF1A42603" modified="2019-07-31" version="1">MTVPATGPHDEHQYLNLIRSVLDSGDVRPDRTGTGTVSLFAPPNLRFSLADNTLPLLTTKRTFLRGIVEELLWFVCGSTDSKLLSAKGIKIWDGNGSKDFLDKRGLAHRREGDLGPVYGFQWRHFGAKYESCDADYTGKGVDQLQECIRKIKNDPTDRRIILSAWNPADIPEMALPPCHMMCQFYVHLPPPDHPDAKPKLSCLMYQRSADLGLGIPFNIASYALLTHMVAHVTRTEPHELIIQLGDAHVYRDHIDALRTQLEREPRPFPKLRWSRNVQNIDDFTSEDIIVEGYDPHPSIPMKMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS28</accession>
    <name>A0A4Q9PS28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uracil-DNA glycosylase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_853674</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS28"/>
    <dbReference type="STRING" id="114155.A0A4Q9PS28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="137"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU57114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="391" mass="42720" checksum="14DC9B0DB9E4F427" modified="2019-07-31" version="1">MSSSVDSTESTPAAATPTQELRNKLSTFRFNEELTPSLRPSPRNHRRLVNLKCEEEEDSLPALGASDVSTTTPSRKRARSSPVEEIDEKPLESSSPKKRRTGSISPKKRKRTPGIAPTEKYAHLDGLSDHLGDDTDMLDVMFCGINPGQMSATIGHHFAHPTNHFWKCLYGSQLTDRLLNPREDGTLPKSYSLGLTNLVERPSAQAAELANTEFTAGVPALFQKIIQRRPRIVCFVGKGIWDSFIRATAPPVGPAVNSEDADIDTKFTMAVTTSVTSSSSAPDPKPPATATSTVKTRSKATVKRTVSRKAKAEPFVYDLQPYKVIHTAPDATVHETLFSVVVSTSGLVAGYQLPEKIKQFSALKKRVDELRRGTLDTSSMTVLPIPKALLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT97</accession>
    <name>A0A4Q9PT97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_537333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT97"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13795" checksum="B0B0E7B2694E898F" modified="2019-07-31" version="1">MMTSGTRPCEARVSLRVRLPGCSQINLRVPRSPNPLRRIRTWGKGNAPAFFRPFRETHAHMALQRGRSVIFATLPASVCPTRDLVLRRSTSSHTIPLFPVGLPSYTRPSFASHGALALHNRAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTF6</accession>
    <name>A0A4Q9PTF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_820980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTF6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTF6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="277" mass="31774" checksum="4EDCCA670E3652A6" modified="2019-07-31" version="1">MAIASVLAPRDVPTTLNYYKPLTDEPPHSYAYAVEGKPQTNVGKEPHPAVVHDARGREAEFSLDKNGFQWVHWPSVEKDFTDDEIIKEKYYPEVERLLKEVAGAKRVFIFDHTVRRSANSEDQRDPKKRGPAELVHVDQTYEASIERVKYHLPDEADRLLKSRVRIINVWRPIAHPVAHHPLAVADWRTLDHANLVPVALHYPHRTGYTYSVRYTPGLEWYYLGGQTPDEVTLIKCFDSETDRARLTPHTAFPDAGSPKDAPHRQSIEVRVLVFDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTG1</accession>
    <name>A0A4Q9PTG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peroxin-7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_949219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the WD repeat peroxin-7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTG1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTG1"/>
    <dbReference type="OMA" id="FAVHWNL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005053">
        <property type="term" value="F:peroxisome matrix targeting signal-2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46027:SF1">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
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    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
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        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
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        </location>
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            <begin position="159"/>
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        </location>
    </feature>
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            <begin position="276"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004253"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00032565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU57772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="357" mass="38898" checksum="E50154A82F44AA56" modified="2019-07-31" version="1">MNRPLPGVLHTPGFAHYGIAWSPFHNNRLALASSANYGLVGNGRLHIVGLGLGPGGLPQPGIDKFYETQDGLYDAAWSEIHENQLVTASGDGSIKLWDVMIKVGSARISDLPIRAWQEHTREVFSVDWSNIAKDQFISSSWDGTVKLWTPDRPRSLTTLQAHPSCVYQALFSPHQPDTVATCSTDGTVRIFDLRSPAYMPSAPGANSFTAPLAAAALTIPASGGEVLTLDWNKYRPWLLASAGVDKAIKVWDCRMVKLGPDAAQNPAVGGVCEAHLAGHEYAVRKVQWSPHRPDVIASASYDMTCRVWSTTPQPGAGHLLYIHDPHTEFVVGCGWSLYDEGVLASCSWDCRLNVFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUD9</accession>
    <name>A0A4Q9PUD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_977811</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
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            <begin position="355"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="529"/>
            <end position="732"/>
        </location>
    </feature>
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            <begin position="45"/>
            <end position="98"/>
        </location>
    </feature>
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            <end position="256"/>
        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="895"/>
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        </location>
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            <begin position="206"/>
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            <begin position="221"/>
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            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
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        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU57954.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="949" mass="105422" checksum="8F7CC2552FB5600E" modified="2019-07-31" version="1">MKCPSGSHSIDLLTIASNVAKDPLPNAWHTLVLEDPLPRLPRGQASELAQNQGKSNPRRGSPAQAHNVTNKEDEVGPELRSSALHGQETLTVGRATKHRTPKWEEGRWAWAEGSHLAVQSLKHLALTATAAHLDEHALYPPRIRGDIMRFLNTRTGEFVERDPKETEYAILSHVWDSQGEQSYMKLSEIQKRYNLQARCLLHGTKSPPPTAAPPAPPDFSPLPSSVEHSSSAPGVHGPSTPSVSSTSDGAALPSHHLCPADIENERQDDPTTTHTEQPRLSRCLDTVWQFVLLVLLFPAYLQPLPSPDPQDSSPTFDDSRKTSHTPVEPSRDPPPHATEGDRSKTPSCCIWGDPELSSKIREACRVAREAGYDYLWIDSCCIDKSSSSELSESINSMYQWYGRSVECYAYLVDVPPGEDPRSPESKFRSSRWFRRGWTLQELIAPSEVKFLSNDWNIIGTKLTLVDIVDETTTIPWEALLRLEPLDVFSVAERLSWAARRETTRVEDRAYSLFGIFDINMPTLYGEGERAFRRLQEEILRRVPDQSLFAWQYVYQGPDMSEQPIACEVEYTLECIEWSPNVLLASSMNAFGADSRDIHIVPHAVLDQLQLSSLSTIEYTPTPQGIRTQIPLLPLSCFFPQSATIEYLNEIPGSQWYLAILGCEHKSSPGSLLGRVCYISPSGTGVDLLCSGCVVVSPARSRGDHRPDLFPLSLATIEHCRKHIALKMVYISYSERASTQSDPEDARYQPHKTINLVLRRKTRDALRAQGYTAELRGPDEGHPNTHWLTLSCDDHTITVEYRHTLEYHGRELEVEADAKMSRDTLGEAEEIEANPSSVRWSGYSSWFMSLNTEKMAFILATKKLTVELGLEWAAPSHYFLRVNIVTETLPVESSTSLELAQGTQAEGSGAGGDAGEQDIGAEAGASAGGVLQPDDALLPMQHSDDTTGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUL3</accession>
    <name>A0A4Q9PUL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_497781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUL3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="51129" checksum="EC48F0EE3C530C9B" modified="2019-07-31" version="1">MSPFSKSNHRSKPASLSLSSSGSTHSAYTSISSFSSPSSSVCSPSSSHSRQDTEESIQSTLHPPSVDSGYASSSESRGYLSPHPDYMLSRTYENWKIADAATQRLFVDLKSLEECKEQLRRANKRRVQEPKSPNPKRKPSLLTMPFRKRPVEQPPVTLPPRSPSPPRDDLPTVEHLQAQIDILTKRIEATQSASERLDACFEELRKVLDDGRPTSWRSFTSSSSEDGYPSGHNFADDYTRARRTVAARDQAYSDSKAMTAAMQHACHGIQSAHHHYRQAMDLLDAVCSPNKHRWEAVMGDEQSRQETYREAADWAQKAQICFNECVRSLTPHWELLKQDELQDCEDIEQTGLLQAVQLYNLMYGGKVLQMGITQQVQVMIQKQDAMFERLTNFAVWVQNCTQECSVVELEGREKRDAARRHLVELWVKADEENENFSLVAPSMSVHVGSGNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUS2</accession>
    <name>A0A4Q9PUS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8065" checksum="7672FADC5F4BBF6E" modified="2019-07-31" version="1">MSVRLRREATVRSSLCLPPILLPSSVRRVVISSLPSPMLGPSLRECCVTSLHPWVLVLSGSSSPVAPLETILLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVN6</accession>
    <name>A0A4Q9PVN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_878692</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVN6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVN6"/>
    <dbReference type="OMA" id="LTKYGCG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="131"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU58529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="538" mass="58986" checksum="75700C10B9CE54DC" modified="2019-07-31" version="1">MSNSSQSLELLFTFLSRSYTTLETNFFKIPGSAVVARYVKSSHQNDPGRTLLEAILIIFAIRTLLQSRTRGDQSAKHFIQFDEKEIDELVDEWTPEPLAQPLSAHEQAELASVPVIVGPNGPKPKLASGKIVTNLASYNFTGLAGNEEIKVAALDTLKRFGLGSCGPPGFYGTQDVHIQLEKDIADFLGTEASIIYSQAFATISSVIPAFCKRGDIIVADRGVNFAIQKGLQISRCTIRWYDHNDMESLEHVLESVEKERQKRKSPLTRRFIVTEGIFDHDGAMSDLPKLVELKKKYKYRLILDETLSFGSVGRTGRGLTELYNVPASEVDMLVGSMATGLSSCGGFCAGSHVVVNHQRINGTSFVFSASMPALLTVAASEGINVLRNSPSILTTLQENVRAVRAILDRVDCIHIPSHPASAVIHLQIRWPTLQVPSAMTATPSSSSKSSRSNPLLVKPRDPPQFNVELEERLLQEVVDEALAQGVLITRAKRLRGQELIEVRPSVRLAVTAALSRKDCEKAAAVVKAAFVKVVGKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVU5</accession>
    <name>A0A4Q9PVU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_818924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVU5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVU5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38503" checksum="B46A4F50EE4F2440" modified="2019-07-31" version="1">MSQSTQAISLVIPSTIYSSGSQVEGEVLVDFRQSTQDKIQEVHVKLRGFAQTMITRDKTTLREVHPLVFSNLSLWSHGGEYPAPGSDILRLPFRFRLPDMLPPSFQYSGFQKSASVLYSVTVVGVRSGTFQMNRRIRVPLVVLPRDVHGMQVRQAIPSSGFRTVYVEEKIRRGLWGDYATARVEFSLPDIQELPLFCDIPYQVKIITTTAPLTAAKAAAQPEDKPIFPSPPSNPTDNNLKLCGRILLRARQFTAMADSDITYILGEGTNASKTKVTVETYERVWTPLRTREEKKEAGGPEERGVWVQKIKFSAKMQLTVPPSFVSRLIHSEVNLDMFRVGRAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW96</accession>
    <name>A0A4Q9PW96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase/reductase SDR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_878216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW96"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW96"/>
    <dbReference type="OMA" id="HGNAGQI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF133">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="286" mass="29615" checksum="06A9349496090D07" modified="2019-07-31" version="1">MADRLAQVAGHLSGAYPRGLLAGEVAIITGASQGIGRSVALLFAKEGAKVVVTDLEEKKAQLVVDEIKLAGGDAIAVGGDVSADDFPEKVITATIQKYGKINHIVNNAGFTYDRMLHTTPDDAWDIIIRVHVRAPFRLIRAAAPYLRIKGSTENRSIINVSSTSGLHGNVGQANYAAAKAAVIGLTKTITKEWGPFGVRANTVAFGFVQTRLTAAKESGASIEIDGKKVALGIPQAAGKGVNPYAHIPLGRSATPDEAAGGVLFLASPLASFVSGHTLEVTGGAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWU7</accession>
    <name>A0A4Q9PWU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MDM10</name>
        <name evidence="9" type="ORF">BD310DRAFT_925808</name>
        <name evidence="8" type="ORF">BD311DRAFT_749516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion outer membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MDM10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWU7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWU7"/>
    <dbReference type="OMA" id="VPGYRQI"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="444" mass="48893" checksum="3D0953D387B22FBC" modified="2019-07-31" version="1">MHPFASYVLRSYYKETGWNEDNLYANLTRSSNALLDFSVPRGLHFGISKSPNPLFKTTYSMNALPSLNGSVGYIFTSCNLNVKGSGDVRFKDMVDRFKVFDRPRRPEGKEEEWLAGERADTRDYLLYGRIYIPTGRLDALYSTRLAPTLQGMVAAISDPRTPLYSEMSRSHAPASNIMFSLQHDTGKVCTEYTWSAEDGMWGIRSLYNFGRVGTPAEASPEEGEKAGNASPARQNGVKVKRVDEEDAMEGGLKGRVSVGGEFYFSAKEKSAGVSTGIRFTTLPDATPPSFQVPTTSSAGSSAARWPPSQPPTTITALFNPMLGHISGAYAARVSRDLSLASRFEFNVYSYESEWSLGAEWWQRQSKARHPPSVSDEAHPPLLPDWADEVQGVVKAKVSTTTDVSLLWEGRLRNVLVSLGVVSNLSSRSKPIKSIGLELSYFSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX09</accession>
    <name>A0A4Q9PX09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_925669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX09"/>
    <dbReference type="STRING" id="114155.A0A4Q9PX09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="293"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="686" mass="74880" checksum="CFA57F7A14EC4981" modified="2019-07-31" version="1">MAKKGAPTLFNPRPSRPTLPKKETPVADTPSPGSSSQPALTPNPQSAPGTPKKPPAATASPATRPAPQRRAPAPKTEDDTAPKQPDGPFTEYRLMSSKLNGWKYDVMKFESRKKVEINDWARPVKLNRKDPHRNDPTMQPAQQALAHMVGSDGKLVIGQDGKVVMVDALGRPVREPVEQKEDKGKDKDKKPKRFQKKTRQVFLVPEATRQLRREEKFPWVIEDGMQKETWVGKMEDVSKSQTYAMFMPAANDVFKFVPAHRWYKFQKKPSHHIPNLEEAESLMTKLQKRKDATQWALRQKTEQAAASGSSLVHNASQSLGPGGKKLRTVDSGPGGLFGDGDDDDEGGDSKRRVKRELGAEGFLDELDFEETFADDEDKMDHDDKEDEETKELEERLKREYKTANKLREGFIDESDDEEDESKLTGAGKNLQKTLKKLEKGGGYDESDDEKNPYASSEEEEEEEEPPQVHTGPAILPPESKPGAPLGTQTPPGPPTGAKAMVNGTVPVKTETPSRATSPVPGHSGHSIVAKRATSPKVPKPKTGMPSRAGSPLASPTGASPPASRATSPGRADSPPSGVNPPPEGKLLKRKADDASAASSDGPPRPKKRKAPGELEDRMVIEWLRNTPNATTRECIMHFTRYLTDDAKKAKFTALVKEVAQLSNGVLVLRPAYRGGNAGAPSPPAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXZ5</accession>
    <name>A0A4Q9PXZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Monothiol glutaredoxin-5, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1038408</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXZ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXZ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000005">
        <property type="entry name" value="Glutaredoxin 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00365">
        <property type="entry name" value="Grx4 family monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF16">
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    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00067618"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU59479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17364" checksum="278215A44FCB608E" modified="2019-07-31" version="1">MFRTALRSSFTALRAPARVPAVALGSSPSLPFAVARRYISQEVRAKIQKAVESTPVVLFMKGTPEAPQCGFSRAAVQVLDIHGVPPEKLKTFDVLEDSELRQSIKEFSDWPTIPQLYVNGEFVGGCDILLNMHQSGELDQLLVKNGVILPEEAQKEEA</sequence>
</entry>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="TBU59426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A4Q9PYX2</accession>
    <name>A0A4Q9PYX2_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_923887</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        <location>
            <begin position="23"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A4Q9PZ60_9APHY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="187" mass="21014" checksum="56369DB7E9D0B088" modified="2019-07-31" version="1">MMCYEPMELLYLTVYLVSLAIVVNIVIIPPSSLDSKIIPLDQEPTSRPSGPRLEKPRILRGGRTGDTVACRVRLPGLVRCVQRAVKCVLVHSAITRWENTLRVCGLSHMAWESTLAVYRCTRSEPENASKLPRCSIEPEPACVLRFALFPAESRVPFEFGRVTYTGASGIAHHRQVRHQYSYICTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZU0</accession>
    <name>A0A4Q9PZU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_346888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PZU0"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11851" checksum="BB1A50AA05B7E8A9" modified="2019-07-31" version="1">MVVLGALFRGTLTRRVNFDFGRVITMWTASDSDMLPERLSMADSLCNGQDAGYDASVRNMMYLAGVHVVQGITGEWENMYAKGIEPQNIGTLGCNPPFGLGTHSCFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0R8</accession>
    <name>A0A4Q9Q0R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Bifunctional P-450:NADPH-P450 reductase</fullName>
        </submittedName>
    </protein>
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        <name evidence="18" type="ORF">BD310DRAFT_1004596</name>
    </gene>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
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    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU60406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0R8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0R8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06206">
        <property type="entry name" value="bifunctional_CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11068">
        <property type="entry name" value="CYP120A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Bifunctional_P450_P450_red"/>
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    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
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        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
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    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
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    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
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    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
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    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF127">
        <property type="entry name" value="BIFUNCTIONAL CYTOCHROME P450_NADPH--P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="P450"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="13 15" id="KW-0408">Iron</keyword>
    <keyword evidence="9 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="16">
        <location>
            <begin position="494"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="17">
        <location>
            <begin position="673"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001917"/>
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    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000209-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU60406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117917" checksum="23817E0FC39F87BF" modified="2019-07-31" version="1">MTTPIPSPPALPLLGHITQIDKEVPLRSFELLADQYGEIYQLNLITRQSIIISSYDLMNEVSNDKRFSKAVVGGLVETRKGLGDGLFTAYPGEENWGVAHRLLMPAFSTAKVRDMFDDMVDIAEQMVQKWERFGPLHVVDAVEDFTRLAFDTIALCAMSYRLNNFYMEQSHPFVQAMGDFLLESGLRANRPPIMNTLMRGSSAKFEADLKTMNELVDELIQYRKSHPTEKQDLLNIMLNGVDNKTGKGLSDENIRFNLLTFLVAGHETTSGLLTFTLYYLCKNPEAMRRVREEVDEILGEGPIRVEDISKLKYISACLRETLRLSPPAAMRAVEALEDATLSGGKYFIPKGSRIGILTAKAQCDPKVWGEDAREYKPERMYGENFEKIPQNSWQPFGYGMRACIGRPFAWQEAHIALAMVIQKFDIAMDDPSYTLEIKQQLTVKPKGFYCHAIPRNRSSSPIAVAPTSTLIGLPQMSQVSSKETEPKVEPKHKLYVAYGSNTGTSQTFAQRIASEAPRRGFKASLGTLDSITDHVPTDGPLVICTASFEGEPADNATHFFEWVQSLKGSEFDGVKYTVFGCGNRDWVRTYQRIPKAIDAILEQRGGKRLQERGIGDAQAAEFFEVFDDWEAKLWNALATEYNLQVAEDAALVSSISIQTIDVGTTRASILRQSDADLGKVTENRLLTSPNAPAKRHIEFELPEHMTYRAGDYLAILPTNPQRDVHRVTARFGFSPEQQIVLGSSGPTSLPVDRPVSVSALLSGYVELSQPATTRDLRILLSVKSSDATKVALDSIQASYSEKVLGKRISVLDILEEHPDIQLPFGTYLEMLPAMRVRQYSISSSPLHNPQRPTLTVSVVEAPALSGKAEPFLGVASNFLAGLRAGDVVQLAVRAASAAFHPPEDPKIPMVMFAAGSGLSPMRGFLQERAVQKQAGREVAKSLLFFGCRSPQEDYLYGDSDLKEWQELGIVDVRPAFSRSPEVSLGFKYIQDRVWHDRLDVRNYFDNLGAKFFTCGSGKVAQGIKKVLTDIIKEARVCTDEDAAALFERAIQGRYATDVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q151</accession>
    <name>A0A4Q9Q151_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_814386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7962" checksum="2E8A67B2D48404ED" modified="2019-07-31" version="1" fragment="single">EGIYWKYFSGNTDLLKGELLDDEGHSKSDPDWAEMEEFNVAEPDWEPELEAEQGWEQEAEKELEQGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1S2</accession>
    <name>A0A4Q9Q1S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_947030</name>
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    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22573" checksum="C69B77ECE4D6F70F" modified="2019-07-31" version="1">MPASRYDTSYPVIDNSELTQDEQSFFPQMKQKRFYVSSRQGPQKAITAAIEAPSSNVTFIIGTADGCMLSFATEYRYIGGNAHASLVAGLSVSSSDTVRSVSFDDRLREIDGKAYTPASGDSTVFVVEVENVEAVRVNQKVAIAASGLLVTIGGEAPQVQEYHHPCALHLSPSPSLPRSSLCSYSPHPQPLLVLCLPRYQQRGMGMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q365</accession>
    <name>A0A4Q9Q365_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_812641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q365"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7780" checksum="CB33E555023D818B" modified="2019-07-31" version="1" fragment="single">HQENITDLYRYLGYLTKYLKYPKYLKYPKSNGLGQVGWVDLAKYQVLGQVLQVSVQVHAQVHCEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q380</accession>
    <name>A0A4Q9Q380_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_784277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q380"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5546" checksum="B86EA69465D19C99" modified="2019-07-31" version="1" fragment="single">MCYHQVQPTPYNPPRPLLLCVATTELVVVADIIISLLPMPFHPSVAELCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3U8</accession>
    <name>A0A4Q9Q3U8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Spb1 C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_956459</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3U8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3U8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="243"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="657"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="428"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="790"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="838"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="619"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="838"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="868"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU61967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="881" mass="99695" checksum="2347833F414AA49F" modified="2019-07-31" version="1">MGKAQKKTGKGRLDKYYKLAKEQGYRARSAFKLIQLNKKYSFLESARCCIDLCAAPGGWLQVASKYMPLNSVIVGVDLVPIKPIPRVVTFAADITTTNCRNLIRNELKDWKADVVLHDGAPNVGTAWVQDAYSQSELVLMSLKLAAEFLIKGGTFVTKVFRSVDYNNLIWVFNQLFGKVEATKPPSSRNVSAEIFVVCRDFLAPKHIDPKFFDPKHVFKDLTASAPAEEQAVAKNAQANVFQPEKKRRHRDGYADGDYTLYKDSGAADFVRCQDPIAFLGTYNKITFKTDEEKEWQKLDITTLDVLANCEDLKVLGKGDFKTLLKWRIALREEIGLEVKTKPTEELTETVEVVEEVDEEAQIQTELERFNAEAAARAKRERRRANEIKARTIQRMQLRMTAPMDIGMEQSDAALRGQDDIFELDDASNALKGQRPEAGYDESSDEEDGDVEGEEDDDEALDSEEERERKVAGLEEELDGLYDAYREHLRERDAKYKVKEARKNNKLREETWLGVGKGDESDDSAAEEGGYERVQRAKARIGEHDSDSSDDSSDEASEAEDIRVAGKKRRRTDGPAEGPSKSKKARTAAKLEEPKPAPSLSRSAQLWFEQDIFAGAGEVMVDDEEEDEEEDEDEDEDEDEDEDEDVSEEDEEAPSGEDDFDDFEIVPQDQDDDVEMWDVEGENEDEIKQAKIQKHGLITAEAVTLAQALVNRQKTRTDLINDGFNRHSLNSKEGLPSWFLDDEQKHYKSNLPITKEAVAALRAKMRALDARPIKKVAEAKARKKFKAAQQLEKAKKKAEGVSETSDITEREKAKQIEKLMEKGMKGKKRKEVKVVVAKGVHKGLKGRPKGVKGRYVMVDPRMKKEMRAQKRKEKANKKRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4R9</accession>
    <name>A0A4Q9Q4R9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein YAE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein yae1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_811186</name>
        <name evidence="10" type="ORF">BD311DRAFT_672576</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YAE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143488">
        <property type="protein sequence ID" value="TBU24071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4R9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4R9"/>
    <dbReference type="OMA" id="TEEAGWA"/>
    <dbReference type="OrthoDB" id="20086at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038881">
        <property type="entry name" value="Yae1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18829:SF0">
        <property type="entry name" value="PROTEIN YAE1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU24071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU62373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="22917" checksum="C6F549951055B07A" modified="2019-07-31" version="1">MDDEEFWGNDPKALQNTEWEKISNDFTNAGYREGITAGKEGALQEGFDDGFASVGAPLGRDLGILRGLSSALLAFLSRAPGPPSIATDPRVAEVRAIATELSNVRLSDIAPPDLQALAHAREHLDGEGRDRDARMDDEDDVTDPAELNEALKAKRDMESLEDLMAQMGGVIEGAGADARLKPARPTAEDVARLKERLLAIARELGLGIAVQWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6B6</accession>
    <name>A0A4Q9Q6B6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_809711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6B6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7478" checksum="AB3A4A1C27FC84B6" modified="2019-07-31" version="1">MVTKKPRAPRKTPQWPPPNDLRGNKWAHARQWYSQTNGSQAAFEDYYKSMTPNERRVLPRFSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6Y6</accession>
    <name>A0A4Q9Q6Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6Y6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020499740" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6615" checksum="FBEAAD40ED3379B5" modified="2019-07-31" version="1">MVSRVSGALRVGTFVFIFLGCWCCHSELCSCFCLHYYLQRYEQCSYGFYILDIRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8Q2</accession>
    <name>A0A4Q9Q8Q2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_578180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8Q2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="39"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="349" mass="38460" checksum="F0DB7D3F071A289F" modified="2019-07-31" version="1">MSSSSLSPLASLLPPGVSVTKGLELFFQVVQDTFTTNLVAAAAVTWMGYDICLTVAEEVELVWRSRWTLSKFLYIGVRYYGFAAALFYFIVNTSMSAPFQLCRGWGYYGAFGATTPIVLLSEALFLLRIWIAYGKSKKILAFVLVCYIAEIASSLAIGIVEGRHLIVLQRPSGFPLPGCFTTATVSLKNTLPAWVVTCATSTSYLVLMIHQFVNSHAFKAELIRVRRDPLGEWFQLHKLSPLVYLLVTDGLLYFAMMFSASTLNMAITIHFNRREIQATGVPVILAVSSISASRLTLNLRGVTALQREKFPSQYTTMYFEPADAPRGGSAEDPREASIADRPSATIVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q976</accession>
    <name>A0A4Q9Q976_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_915440</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q976"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q976"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF5">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="155"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU64143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="386" mass="42682" checksum="4B2EE18C955462F0" modified="2019-07-31" version="1">MAPIKTCVIGVGLGGLTFHAPFVLALPHLFTLHAVMERNPATPGGKLQARFGEEAAKGVTIHRTYDAVLADPDVELVVISTPSETHYEFAKKALEAGKHVLVDKPVTAHFSQAQELGALAKSKNLVLYPFQNRRWDSDFLALRKLLDLPADHPQSLGTLYEFESRFDRFRVELKGTWKDLPLEANGLVYDLAAHTIDQVLVLFGRPTKLTAFRENIRGIGSKDVDDAFTIFLHYPPRPAAPSHVQPTSFTAILRGHILSVRSPQVRYVVRGTHGTYLKYGVDVQEDQLKVIPSPAGIVQSESYGVEPEEIYGTVESLGEGGEVVKSVWPSTERGQYVKLFENVAAVIRDGAEQAVKWEESAEVIELIELAYKSAAEERTLPVPPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9J8</accession>
    <name>A0A4Q9Q9J8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_807863</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9J8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9J8"/>
    <dbReference type="OMA" id="HKHLGYV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22670">
        <property type="entry name" value="FHA_MEK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="7">
        <location>
            <begin position="55"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="164"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="469" mass="52566" checksum="D8969955A8C5D491" modified="2019-07-31" version="1">MPPSRTILSTTDRSPAYEYHEESDPHPSVTICAKFVTTTRTGRKDVLLLSVNKPLSIGRSPGCTYVVPDAVVSGLHCKLYAVRSSHGGIIISCQDHSTNGLILNGHRVRKTSILLMDGDLLEIPSSQKFECIVLHKEPEKKVNVFDPTPPALPTLKTKKIDRYLVMSHCLGSGSFAEVHLAMDTSAFKQVACKCIKRKSSDKIEKIRKEVDILLNLSHPNINTVRAATNDDNFLYIFLELCTGGDLFSYIVSHPDSQLCQAEAKYIMYQLLKGLKYLHDRLISHRDLKPENILLYAPGPYPRIQIADFGLARPKAYQETFNVCGTVSYLPPEGILALDHKHLSYVGMPSDCWSSGIIIGCHPFDYGKVDGESEMYSYMPESEGEDYDDSQCSQTSIQADQLVKRRIVHGEVEFPSPVWDKMPRARDLCSDLLVYDPMDRATAQTALRHEWLTAELLDLELAYRSRIGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB14</accession>
    <name>A0A4Q9QB14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Alpha-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_804815</name>
        <name evidence="11" type="ORF">BD311DRAFT_745486</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="3 8"/>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB14"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB14"/>
    <dbReference type="OMA" id="ELTCARY"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005995">
        <property type="term" value="P:melibiose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000202">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF75">
        <property type="entry name" value="ALPHA-GALACTOSIDASE MEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597668" description="Alpha-galactosidase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="10">
        <location>
            <begin position="333"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU35049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU64867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="451" mass="49375" checksum="B754E01E5463A329" modified="2019-07-31" version="1">MARKLLALVSAVPVVVALNNGLALTPQMGWNTWNHFGCGINQDTIVNSAKALISNGLDKLGYEYVLVDDCWQADARDPDTGAPVEDKSKFPDGIKAVADQVHSLGLKFGIYSSAGTYTCGGKFGSLDYEEIDAKTYASWGVDYLKYDNCNNEGRAGTPQISYERYNNMSQALNATGRPILYSMCNWGEDGPWNFAVNIANSWRISGDIYDNFDRYDDRCPCTSMLDCKLAGFHCAMSRIIDFSAPLGQKAGKGHWNDLDMLEVGNGGMTYDEYVTHFSMWALAKSPLILGNDVTDMSDETKQIITNDAIIAVNKDTNGSPAIRVWKKPVSQGGDIQLWSITLVNYQWVFAVLNTSPVNQTVDISLLDVFIDQGSSFGSGTFTLSDLWQKDSSGNWGASVGNAQGTFTVSVNSHATRVFKAVPASSSSRREFETVDDPHAYYPGGDSRELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBG6</accession>
    <name>A0A4Q9QBG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CyP450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_297890</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBG6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU65033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="530" mass="59633" checksum="E5594C4A558199BE" modified="2019-07-31" version="1">MMFDIISPVALLSLTILVELLAFRYFRSSRNLRTLPLPPGPKRLPILGNAHDIPLNKQWLTFQRWAEEHGDVVYLNLLGQSVVVLNSAQAITDLLDKRSAIYSDRFKSTVVPLIGWDWNVALMGYGLKWRQTRRAFHEYFHSGVVQQYQHTQLSGARKYLTRLLENPGNFVQDLRYDLGATILEVSYGIKAKDTGDEYIAIGERAVEGPTKALVLGALWVEFIPALRHLPPWWPGASYLRKAGTWREEALALKNVPFTKAMSDFRDGARFWSIASDIMAQDHGLGDALEKEELAKNVAAVTYGAGADTSFSTLQTFFLAMALYPEVQRKAQAELEAVVGPHRLPEFDDQKTLPYIHGIVKECLCWQNVFTLGFPHRLMEEDEYRGYRIPRGSIVLGNIWVMSRNAKAFPDPEVFNPERYFKEDGTWNADVPDPSLFAFGFGRRACPGRHFAIASIYIYAASILHAYNISTKRDLDGKPIEIKADMVSGVVTYPEKFDCDITPRSADAKALVGFCATEGGSMCSYSDEANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCJ6</accession>
    <name>A0A4Q9QCJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_9711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCJ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCJ6"/>
    <dbReference type="OMA" id="VDQDWVG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061157">
        <property type="term" value="P:mRNA destabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF89">
        <property type="entry name" value="YTH DOMAIN-CONTAINING FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="795" mass="84852" checksum="F114F7BABBD99B61" modified="2019-07-31" version="1">MSSQSGNPISPPPGAASNANAGGVRRHHTISASSRTARPTSKIALGELDDPQTEQFWNDDEPVDQDWVGGIGAVGEKSSLHRQASLPTRYHRTFGGSGARQPGSHTPRTLNSLSAIAGHEGDEEEWERDMRGFHNDDEHPGMSVSDHGHGDSASVSPLSPHFSGLPHGPSPPPGTAGAGGVRRHQSLNYPTTTPGVRRLASGLKRAGTLQVGAKGPQGYSGAQSPSPTNADEEYEDEAHVDDESYFALQNQQGGQYPGSPIGRSSPWSTPGGEWRAQMGGNGGSYNNTAGNNAGIDDVSRALSALEINQQYANVQQGQSVHPPRFNPSHPPPVQAPGLRSGNGGGSRKLQLVTDLNGRDGQAVQSASAFVPPIGHPGQGGQQSEQQQGQHPHQRDRAFTASGTPWEQKERLLVPRTSNPGLASLYQQGKMDGTGQNVPSVPSIPAQFLNQGQAPRLGVSSSAGNVASQGQGQGANQGQGNQSGGIDGFVGTPIDVPTLIATKGYNPVDFDTRPAFARFFVIKSYTEDDVHKSLKYEIWSSTDPGNKRLDKAFKETAGRGPIYLFFSVNASGHFCGMAEMLTPVDYTRSSTVWASDKWKGVFKVRWIFVRDIPNASLRHIRLNNTQERKPVTNSRDTQELLPDAGQEMLRIFHTHPARTSLLQDFAFYELQAMQKAQAQALTQGASSPSQTPIGVQTSGNQGQGGVSPTSTGQHPFAMANPTALAYAAQQMGLPQMNMNMGMGMGMQMNPMLQMQMNMGQPFVNPQAMQSVMRNPSPGPMPVSAQNFMNLGGMQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCN8</accession>
    <name>A0A4Q9QCN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_911291</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCN8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCN8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="778" mass="85340" checksum="21E00C8C5C2774C5" modified="2019-07-31" version="1">MSRQLRTRASRPNYAVLSGYLEPDEDGAGPSQTREYLEEDDSGSEFEPDAVPEQQGADDAEDMALDDAEPEDEPEASTAAANPRRRQTASTRESSLAGLESASVGPRRKSAPPKPPAKRSVVLAPGLSHFSNRQQHALPSQNHRHRSFGIHQKDGKTERLIEPPRLFEPASITLTNAWGVNSFVVERLNKAWGYNIGPGPLWDMAEDRGWFKEAYGSPNTTEKERRPRVHEGLRLGAYRLLSPSEAIPYLPSDVQNTHEGAYKPPPPVACSFGPFGKQTRLEVNRLDSIRTARFFPGSKAHVFNAGAPVWAIDWCPIHPDDRSYYQHGQYLAVAPFPSRSYSPMIGSRVQRPSSACIQLWSLSSSPADENAMDVDGGVSDAGEMRCELVLCLDSGPAYDLKWCPLPANDSTVEANDATPRKLGILGGTFGDGSLTFYVVPDPKTIDAPADHPANTPLYVKPTKPLLRIELEETCCWSLDWANSEVVAIGCTNGNIAIYNIATALYQQSSMPFFPTHYFTVHQSAIRSIAWIRVPVCDADGEETSDDPTVLVSGGYDGVETITDIRELRGNVMNRTRDVVTTICYSAYAGSAITIDHENIIKAYSVAPIMLGRGHTLLEPNGPIWSLAASDYHPQIAIGVTDGSCLTTNALRSTRRGGLIPFMEHKIYQLDYSRAVGEYRMLEHFLPKETQNRPAATRQNKTIPVGTGAWPPDVGIHRVVWNDRNGLAGTPLLASATGSGLCRVDWLPGKWGRDPLPYNGVEGMRAETGGEFDEDDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD97</accession>
    <name>A0A4Q9QD97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_20241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD97"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD97"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="264" mass="28845" checksum="71678D3B3F6AB92E" modified="2019-07-31" version="1">MLSADPAYDDIPNSRPYAPLYRSCASHCTSAWHSGPNKLAALSTKPLFLALTALVGAYLLWYHLPASLEFYPHLSPSWTSSDPTMSSEHASAQGWHARANPHPSAASFAPTKDALVFAALLNAPADPQGFTLALFEPDLAVDARGRVLQLRPQDFSRLAALAREAAQLPDTGSIMNAWRVAHDRTSQKIDRLFVKTPGGDVRETSVQGWHSEKKQLKTAVAGHQELPPVLQELFGDIQEGRTDFVRGQEENDDLISQVKTLVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDC3</accession>
    <name>A0A4Q9QDC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_971876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDC3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDC3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050910">
        <property type="entry name" value="JMJD6_ArgDemeth/LysHydrox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480:SF6">
        <property type="entry name" value="2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE JMJD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12480">
        <property type="entry name" value="ARGININE DEMETHYLASE AND LYSYL-HYDROXYLASE JMJD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="122"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="413" mass="47443" checksum="BD67D6F5AACBBA68" modified="2019-07-31" version="1">MPNRGCMECQCPKLDRTPSYAEFLESYLIPNNPVIIGPSLVSSWPALKHWVTDEGSINSDYLKTAYGHYEVTVADCSTRNFSDQQREQMLFRDVVSLWQEDKGETLYVKDWHLARVIAADTTRAQPDRPFYTTPDIFRDDWMNAYYSACTEDDFRFVYVGASGTFTPLHRDVYTSYSWSTNVCGWKRWWLFPADQTPLLFRKGGEEHMETAYDVRDVDLALYPLFEQARPIVIEQGPGETIFVPSGWYHQVENLTACISINHNWCNSVNLPSLYDFMCAKVTEVEHALEDVKELLSQGDANSSRDLSSSWRKEWIAIVQDLVEKDAGWNWLTFWKMIRHALSLAMDWPCPVDGCLWARTPSELMPSLDYMATRIRNCYEDFAIRPQLEGSLIPGMDEVLADIGGLLNYGASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDT4</accession>
    <name>A0A4Q9QDT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDT4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020281097" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9571" checksum="209457ABC2C8BA5B" modified="2019-07-31" version="1">MSRPCVTVVVPGNWSLVLALMDRSGGIASPMTCSRPRPRRPLTCPDVFPHPLLGCSPDILSVPYDALCERELVPRSDTSYITSCRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE09</accession>
    <name>A0A4Q9QE09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor SLT11</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pre-mRNA-splicing factor slt11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_911645</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE09"/>
    <dbReference type="STRING" id="114155.A0A4Q9QE09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000006">
        <property type="entry name" value="Putative pre-mrna-splicing factor rbm22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00069020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU65590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="319" mass="35242" checksum="667454D69C088F1A" modified="2019-07-31" version="1">MPKADINKAGWEQSEFPILCETCLGDNPFVRMSKQEFGRACGTCARPFTVFRWNPGTGMRFKTTVICQTCAKIKNVCQTCLLDLVYGLPTQVRDTALGIESEAPTSEINREYYAQNMENKLEGAKSLLDVDKSSSAGKEMLKQLARTDPYYKRNRPHLCSFFAKGECNRGDACPYRHEMPVQNELSKQNIQDRYHGRNDPVAKKILSTHAANMGLQPPEDQSITSLFLTSLPANATEESIRTRVLKSLPAVQPSQLKSVVHVAKTRCAFVNWRDRATAELAAQAWANGLEIGGETVGIRWGRSKGASGAKPAPVAVQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE18</accession>
    <name>A0A4Q9QE18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_864437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE18"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="115"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU65600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="282" mass="32213" checksum="0C6673EE5E8BA915" modified="2019-07-31" version="1">MPTDRVRSFQIDLKPRRHHGYAVLLFILGTLLPPLAVAARFGIGTDFWLNLVLTICGYIPGHAHNFYIQNIRNNKTHRRTPKWAQKWGLIDTSEIKRKERRSQWANRYNERLPHSALENQPYAEGEVGGSSIDLSEENNAPRARGPNGEFWDPNEERYYGQNGDAASTATQGSGRWRYPANFDDAVPPTKKAAKKGKKDKKDRWARTEDAYAAQEEGSGRRKKSKKRRSPAADAETYSQRSESTTEFPEDPEGGLYGDRRPPAEERDGLRRTTSEEIFNHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEY6</accession>
    <name>A0A4Q9QEY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diacylglycerol O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_912160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEY6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEY6"/>
    <dbReference type="OMA" id="FRKREPM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="66102" checksum="648E357A03A860F4" modified="2019-07-31" version="1">MTWSLLGSSLTSGKTYVRPLGLNEHTFYFDRVFNGTADILWRYLVQETDRAKGTPLFSEDNVKRAWATLKQWYPLFAVHMDDSRGPDAVQFVVSERDVSDYRPGEVNFLSAKSREEVEAYIWVLQRDKPTEDHHLISRLFVFQLDGQPGTYEILIRVAHAVADGISGATVARTFFDVLSSPPTPIPKLEDRLAMAVPSDELNPTRKLSPARQRWRRAIAQSIFLNRRGRCAGGHTIPRTITDKTYRTPSVTGRIGYRFPVLETTAILDTCRAHRVTFGTVIPVISQLAITRMLHRRYLRGDLPEDEWEYRRRQPMHFGGPINLRPYMDPEWQGKGGATEVALAIDYYELTLPFMPAPFGSRRDPSVPRAADGAPPYAALLSRERFFYRGQLCRRQLKAIASSPLVLDIALARQPVYVHRKKTMTLHWLAEKKGEPLPEIPAPPLRDPLPADCVFSAGLSSVGQMSLILPSNYPLPEGHPLSVRTPRPANPHFGAISEAPSTSNSKAPLVPPATSDADALLRIIDETTYLHSRPTEFFLGNGTERGRLGLAVTFDRNTYKTEDVEEYIDECRQATLHYLGGGIVSKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K2X7</accession>
    <name>A0A4V2K2X7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_962969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145292">
        <property type="protein sequence ID" value="TBU51706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K2X7"/>
    <dbReference type="STRING" id="114155.A0A4V2K2X7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19883" checksum="39B3D57F1D011270" modified="2019-07-31" version="1">MLSTETATSTLTDDRVCVDDGGQRCTIEVNDYSATRAGSARRDNDDFFKFLGDEGERGASGAREPWVRVRWIDVGGISWDVISAVALKYDLHPLALEDVLHQRAPPTPARADYHLFIRILVHTLASSAFSSFSDDRAPESTSPPDMFADDKEEADTQEESWRHRNNLSTVRAAGPEQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K337</accession>
    <name>A0A4V2K337_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione-S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K337"/>
    <dbReference type="STRING" id="114155.A0A4V2K337"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="255" mass="29605" checksum="9B8E84502A3D16A9" modified="2019-07-31" version="1">MGLPDEQIHPIATGRAAQTVEQHQESQDLVFYSGWFCPYVQRVWITLEERGIPYQYKEVNPYKKEPHFLAINPKGLVPAIEYTGRALYESLIICEFLEDAFPDHEPHILPSDPFDRALVRLWTDHVSKQIVPGFMRLVQAQDSQKQREYLEEFNKALRTISAQVKGPYFLGEQFTLVDVALAPWVVRDYIVAEHRGYSREAVGNGWKEYAVQLETRESVLRTQSDRVYYTEIYGRYLRDEAQSEAAKAIRAGRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K773</accession>
    <name>A0A4V2K773_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GNAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_934645</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyltransferase family. GNAT subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K773"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039135">
        <property type="entry name" value="NAT9-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256:SF16">
        <property type="entry name" value="ALPHA_BETA-TUBULIN-N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13256">
        <property type="entry name" value="N-ACETYLTRANSFERASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="20407" checksum="40BDE560D6E12D53" modified="2019-07-31" version="1">MTSEELRELTASEPLTLEEEYEMQRKWQEDEDKLTFILLSGMSFDAKEDDQKVTPGRLEGLPMIGDVNLFLKGVPDEEDFEVEVEIMVAEPAYRRRGVAHTALQLILSYATDPSSPKPLPVPKDRFVARIGERNEASIRLFEKLGFSVTKRVAVFEEVELRFTDASKVWKKGDVKLLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-06-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7M6</accession>
    <name>A0A4V2K7M6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_600954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7M6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="1">
        <location>
            <begin position="133"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19851" checksum="59849AB22EE340D2" modified="2019-07-31" version="1">MANLPSFLPDHNVFPHTLCMSLDPPNIPRSLAETFEAPTINHHPSTPLMQLSGGPYVILPISEYLDLLFGDPVRNTAPPQNLKPPSPVDLMMSRPPDMHMPTGSAAVGDVMPLAQPVAPVMKPSRRLGGRKIACVNCHEVRKTCDEGRPCGRCTKRGLECKYPLRKQSRRAAHMSNGWVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8B6</accession>
    <name>A0A4V2K8B6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8B6"/>
    <dbReference type="STRING" id="114155.A0A4V2K8B6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42115:SF1">
        <property type="entry name" value="BETA-SYNTHASE (BETA-THIONASE), PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08420)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17659" checksum="AFF2CC4E205C5EE6" modified="2019-07-31" version="1">MATTSVLTSAQLDVSRLPADKYRGAVVEDLQLPPAFSLPSDEAISRAIEMAYERDFSHIPVLDRNRKLLGYIDVASLKAKWEAGQADPSDKVEKYMQKFKRTAATPYTIITPSTPLAELEDFLSRNIFAIVTDWDRKFVLGVVTSQDLENFVSRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8M5</accession>
    <name>A0A4V2K8M5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter Ostalpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_957611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8M5"/>
    <dbReference type="STRING" id="114155.A0A4V2K8M5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="500"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="609" mass="69318" checksum="DEB27F88CEF58137" modified="2019-07-31" version="1">MAEIVNGRCHAERAPLQEPSLVQNGKIVLQPHHIGWIVSSVLTLVAMGVSFWLIGKHVRNYTNKYEQRYIVRILFMVPLYAVVSTASYFWWNHSTPLLLIRDCYESTVLTAFFYLLLLYISPDVNVQKEVFRKNGLSRQNDKERGRRGEPVQKWVMPLGFVHWKPEDGLYFLQLMKWGVLQYCVVRPGTTLAAVILDYVGLYCEDSWSLGWGHIWITIVVSLSVTIAMYCLLQLYMVVKVELAPQKPLLKLFAIKAVVFLTFWQATALSALTLFGLVKDTPYMTADNINIGLGALLETFEMAVFACLHIKAFSYKPYVTGDTTPRFRSLVHAMSFKETGREIWAGWIYMVRRSRGHEVDTQARREAVLEDVFGRSRIAIYREANGSASGPGKLNSAPEKDLSVTVQVEKEVRVGDERQWLGVGDDYVYGLGYQAKRQRERSEGLESQIEKELARRGYTLQGSGGGAYSPIIDAEAAPTQGHQRGQASWWRRVYDRLSQTGAEMDSDRTLASPSSHPRPGRRLSWRRQSREMSNKVGAAPLMADVQEDDYNDPPPPSAIRTYRESRNKKQPPKRKAPPVRLKRMTVLAGSRHKPRSPIDLALYSRARLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8S3</accession>
    <name>A0A4V2K8S3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_966137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8S3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22236" checksum="C1C1D8FD421C6D0C" modified="2019-07-31" version="1">MSSPAASSSTSHLTFFGEFGRPAATTHDIDVEAQLPPPRPARTNTPRTIRVSVHEETATNAIDDFFGASRSSNTSPTGTRDSRHDESRLSVSAEDVPPPYEHSESMEPPMYTAVADQPTLAMYLFKFGFLFPLFWVAGALILLSPLSAPPDWELTKSTIEREELILSMRRTEVKWARRCAAALSVFVVVALALVLGVVLGMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K955</accession>
    <name>A0A4V2K955_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_810993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K955"/>
    <dbReference type="STRING" id="114155.A0A4V2K955"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19678" checksum="F1ACF94E9A03E934" modified="2019-07-31" version="1">MMKTDILFSSQELRFSRAQKQAILSWGRDLGAENVPSLYKIEKFQADALEACGNPSKRMQTSTGQVFYQNSMHHHVAQQYAHPNVRGYIKAYPVFAGGCVSETYHSSKWLVDAPGTLLTPMVRIDDRDFYVDELTYCNDEEWCIPVRFFEFEGQGMWAVCQKVEMTEVGDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWP4</accession>
    <name>A0A4V6MWP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_934830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14327" checksum="7F6F02B0330326E1" modified="2019-07-31" version="1">MQYGLLQEAFVRRPAGYGASLCQVVRDLSLRSHYNTSLRVSLRHCSSLQSTISLRTAVKPHVVELDMLCQLSGTSINPEFNVCPAFFGIPANGPIYIPSVLATSWAISRETRLVIPCDDPSDYPTLQTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWV8</accession>
    <name>A0A4V6MWV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_921162</name>
        <name evidence="9" type="ORF">BD311DRAFT_771108</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML143560">
        <property type="protein sequence ID" value="TBU22045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWV8"/>
    <dbReference type="STRING" id="114155.A0A4V6MWV8"/>
    <dbReference type="OMA" id="HIILHIV"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU22045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13474" checksum="871B9AA17CDDDA71" modified="2019-07-31" version="1">MPAAKIAPSKTAGSSQSPLLSLWKAYYESTSTRLKTIDAFLVFLMLSGIIQFLYCVLITNFPFNAFLAGFASCVGQFVLAASLRAQVNPANRSEFKDVSPERAFADFALGSIVLHFFVYNFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MSN7</accession>
    <name>A0A4Q9MSN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_813179</name>
        <name evidence="8" type="ORF">BD311DRAFT_659759</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Phi family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ML143408">
        <property type="protein sequence ID" value="TBU30128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MSN7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MSN7"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000039">
        <property type="entry name" value="Glutathione S-transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000004">
        <property type="entry name" value="Glutathione S-transferase F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43900:SF3">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="90"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU30128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23938" checksum="C58AFB9A26FC396C" modified="2019-07-31" version="1">MVLKIHGTPYASCTKRVLTVVEELKIPHELVLVDVENRAHKSPEHLAHQPFGQIPYLEDDGFEIFESRAISRYLALKYGGIGKLIPPQSDVEATAKFEQAASVEAFDFDPLATKIVWEAVFHPGLGLPSDTAAIKAQTALLEGKMDGYEALLSKTKFLAGDEVSLADLFHLSYGSYLKDAGIDFLESPRWPSVARWWKEISSRPSWVKVNVPLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MWJ5</accession>
    <name>A0A4Q9MWJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_803657</name>
        <name evidence="1" type="ORF">BD311DRAFT_654994</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MWJ5"/>
    <dbReference type="OrthoDB" id="2748942at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU32400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="78" mass="9464" checksum="0F9CBBF70B881F34" modified="2019-07-31" version="1">MCHWRRVRNNYKRCGHYVDQPDEMIQCDDRYCKFSTSHPRNCVPPRCTETCWQYRQFPEQYNPVIDAFCPVCVQLGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MWZ0</accession>
    <name>A0A4Q9MWZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_856977</name>
        <name evidence="18" type="ORF">BD311DRAFT_750292</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
            <strain evidence="18">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 21">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MWZ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9MWZ0"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="373"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="589"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU32580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU55316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="862" mass="96844" checksum="1A11CEB808C4827D" modified="2019-07-31" version="1">MSSKRAAEGFADVSHPAKRSKKGQDNDEYVDVDNLEAVEIESPPETSLVPRGATINFTALTRKLADARREREIAEGKDESTLSIHRRQQDALVSHIFQDHDFAWLHLKPDHASRPLWISPEDGHIILEAFSPIAEQAQDFLVAIAEPVSRPAFIHEYKLTSYSLYAAVSVGLQTEDIIEVLNRLSKVPVPESLDSFIRERTLSYGKVKLVLKHNKYFVESSHPETLQFLLKDRVIREARVHSAPVDNSIRAATFTTSKAPVKGNLVIPGTKEAEKKKEELANGKGAGGKTDAELFTSVVGVEHDEVEEDDDNVHAFEIDDAKIDEVKKRCNDLEYPMLEEYDFRNDTVNANLEIDLKPSTVIRPYQETSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSCLVLCTSSVSVMQWRQQFMQWSNITDKQIAVFTADQKEKFAGDSGIVVSTYSMVANTGNRSHESKKMMEFLTSREWGFILLDEVHVVPAVMFRRVVSTIKAHSKLGLTATLVREDDKIADLNYMIGPKLYEANWMELAAKGHIANVQCAEVWCPMTPEFYREYLREQSRKRMLLYCMNPRKFQACQFLIKYHEDRGDKIIVFSDNVFALEAYAKKLGKLYIHGGTGQTERMRILQHFQHSPEVNTIFLSKVGDTSIDLPEATCLIQISSHFGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMFYSTKRQQFLIDQGYAFKVITHLDGLDDLPGLVYKSRDEQIELLSSVLLANESEAELGTDVVASEGDLKGTVTSKDFGTPSKAPTVQRTTGSLTALSGAQHMSYVEQNKSANRKLAREVAPRHKLFAKRDKDVAAARKEARTASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N716</accession>
    <name>A0A4Q9N716_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_913323</name>
        <name evidence="1" type="ORF">BD311DRAFT_801655</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N716"/>
    <dbReference type="OrthoDB" id="1904422at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004991">
        <property type="entry name" value="Aerolysin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053237">
        <property type="entry name" value="Natterin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39244:SF5">
        <property type="entry name" value="NATTERIN-3-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39244">
        <property type="entry name" value="NATTERIN-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03318">
        <property type="entry name" value="ETX_MTX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU34951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="39762" checksum="E6EC75039E8F6A2A" modified="2019-07-31" version="1">MSTLKQKIGPIAGAPPSETILPEYVYFKNPDGKYLKHLPNNIGWYGLKWEPTKPDLNTRFKIVQIPDHPGKFYVTGPAEDYYTTVSNYKNSGSTKLYDTDQSKLPSNAPSPYPDALWRIVSLGGDDIYLIRNATYDRPTVFLSNNDNERYKLWDHNNDSWLDVVRTTTYANDSNKIKVERAALKTEVYDVKYNVDDADLVELQPTIAIEKVLENNTGSEGSQSVAYTYTKSDEGTWNNVAGIELGQSFTFKAEVPFIASTEIGISFTESYQHEWGGSTIESTSVTTTTNITVPAHTKVKLTVLIYKTQLNIPFTYTERVTLYDGSVITTKDKEGIYYNVQFIKDHATTDVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB00</accession>
    <name>A0A4Q9NB00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_651915</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB00"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="23001" checksum="F4B5047734E458BD" modified="2019-07-31" version="1">MPLGHPNFFPAIPVVIPLCLFAHATALFSSARLTACTGYLEPGLLRPVVLAPKGFPHLLEVTLPRPVSHALSPYDYITTWHDMYYYFSITAVRRCEGVCSFATVAVLGCHTSLSARLSPSRTVPPLIRPLVVPQPPCYVSPLNVFLPRAWIIRRSGRSCLLDALSSPHSASSGLRRRLHRLTISDRWYIYTSYFPVPVLCICVASVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NG15</accession>
    <name>A0A4Q9NG15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_916972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NG15"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7185" checksum="1477A2EFC77EC7E5" modified="2019-07-31" version="1">MDVKHEPRGHGNLRQDCEQSRKLVASDPRKERMHVGGMGRHSVALIAGLPESIRKFRRLVDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJD0</accession>
    <name>A0A4Q9NJD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_368847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJD0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJD0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000026">
        <property type="entry name" value="GTPase activating protein for Arf, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="366"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="516" mass="54371" checksum="54ACD9744E6C8DE9" modified="2019-07-31" version="1">MSINKIAAERNQRALMELVSQPGNDLCADCKNRNPRWASYNLGIFLCVGCASIHRKMGTHISKVKSLTMDTWTKEQVEFMRSMGNSKSNAHYNPDETKHPPPTNMIESERDSDLEKYIRSKYQYKSFVTRSAQVAALLGPSRSASDRLSPVPPRSATMPPSASSSSSVSRPAPAPAFPTSSSSTPSAAVANQSQPRSVSQPVAPPHPAPQPIQMPQQLPPQSTTSPPQQSHQLSNPVWNDLAQLQAPATNSSLPLQFASSPATQAINVPHPSSLSVPNQFSGLSVSPNNHFPSSLTQQPTGAFPGGTPRSMSLHTGLSNMSLSGMNSTLGVPGTSPSMFQPQSTMGGGLSAPSTFLSQNTIPSPFAAPSSLPSTNLGISQPSFAPSSFSQPSQPLYTPQPQAHPQASPMFQPQPLGQMQGSPMFQSSPLGQAPTGNLNRNPYGLSPMQASPQPGITPFSSPQPQFGGSPSPAPFMQQPQFAQSNAGLGMGGMPGNAFGGTGWGQPTGFPGQQPRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLB1</accession>
    <name>A0A4Q9NLB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLB1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="237" mass="27725" checksum="89BFB700536B0684" modified="2019-07-31" version="1">MRVNQKDLLAFVVAHDRLREIDMRYSYIFPDDSQHAQVIPHPSLQILTCRTPLLSSQTPVPTNLTHFYRPYLLSRQLPGIVALLGPQLVSLRVGECFPIERSSPWSLLDVVTNFPRLRFFHVEMFHTSLPSLGTTLVDWFRDRQASRVLIARPKIVLAWTNKQQFLRTEKQEIEWDQYVDKFAVRVLTEWDNYIERIIYRHSARPYISVTLDAAGGMGGQLVKAEDTDMRDDYWKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQC0</accession>
    <name>A0A4Q9NQC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_601313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQC0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="17150" checksum="9D0E3CF55F035A9B" modified="2019-07-31" version="1">MRSHPEHSQCGDIASTLSVALILIEHLRPPHMMLDPPLTKPRRFMRHHKMARARSQRAAIPPLTLLPLRFRRHSGKALRMSSRPNSETLPRPPLLASSARLTADPFTKSIITFPESLEVRGLWADCLSTNRTAPVVRMDVEGRRRRNTLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSF0</accession>
    <name>A0A4Q9NSF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_934124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145172">
        <property type="protein sequence ID" value="TBU55253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSF0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NSF0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="606" mass="63411" checksum="353EA26218BC6784" modified="2019-07-31" version="1">MCKATLSWLLPGNAPSMADGWENSLRNPSYWVDRDLSSYVHSTYAQIIASQLSSIIDENKLTPQALWYLQDSREQLHAIAEKPSLQEALLGLAESIPPKVRYATLRVRHVQQLSEELASQPSSPTSPPEESVLEQDDNVAESIGSEFISGGHIDTDISPVSATMSEFPLHIDDTTSSIVLADFTPSGGGAQQRTMTPVQEVTEAPTVLTNADAAPCIAAGPPLGAMNPEEGASAGFRGGESEPRPIAHVEPGASSSESTLQTAGDEPSHSGEETGTTEVPTSAGVLSEGEHNSVPANSNDDASLPGDVPQREVEEIVPSEQCMQHSSREENVPYQEAGAVPPARLQHEGPSECSEDSQEAQRPEEPLSPRNSPDPLATGNMDDQHPNSSGGIEDSQDTTAETPTQDGVPSPTNLDHQTDSRPPALTEEIQQLGEGPDTADSEQPLAEPGAAMPVETSCLAPSGPSSQATNHRPTVQSATPAAASTETCTATTTMTAEPTAPPSSTVLSSQTALLSPKAPPSPTITLESGAEMQLISRDSSESREPSPPPASTGIDPGGAIPHPSPSRQAVSRAGPSTQGSHSSARPQASPRNGGRGRQARHRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NY49</accession>
    <name>A0A4Q9NY49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTPase activating protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_922570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NY49"/>
    <dbReference type="STRING" id="114155.A0A4Q9NY49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="755" mass="83233" checksum="EFF5063BD4A28B64" modified="2019-07-31" version="1">MSEDSFHPRPSWDSTDHRDRDGSSDVDHLPSRADNGKTPAYYNANGGGGRIPQQSAQHFMPPSSDSLSHHGHSLRDEVTPPTPTKAKSVSPHRRSSVESATRPPLAGASGSGSGPGVGGRPWEGMTGVGSGIGVQGLGATGTQSELGNGYAPPRVSVDSELGSESVGHGHGEKERDGESAAAASLAEVATLVEPSFDENILRMLCETDCGVPLLLDRIKQSMASCKEAASFLKKRAGLEDEYGRQMQKLARSTASEYATTDGKAGSFVQAWQASMRTHEQMADSRLKFAMRLNEMSEELNNLVKEVDKNRKATKELATRYERALQESESLTEKTKARFDMTAEELERLLLQKEGESLKDNAMQGRSPVNGKRVIGKAVAKGGMLLKGRNPQNLQRQEDDIRARMSSASDAYRKAVTDTQTIRQEYFNFQLPRILRALKECVDEIDLGTQYHLSRYAFLCESIIHSEATILQPQDDLVLGLKATMESIDNRSDFKTWMQAYVYAHGGQSNRGPRRNGPQDEGFLPPIPALHHPGSSPSLAQAHLSDKGRPTFGVHLAEQMARDDVDVPPILTKCCEHIEKYGLDQQGIYRVGGTHRIVQKLKERLDRDLDSVNLEVDEWSTDISNVTSVLKLWLRELPDPLFTASQHADFMEAARNENERARHIRLHERVNGLPDPNYSTLKYLMGHLHKVVQHEAQNQMSVQNLAIVFGPTLFGQVQPGLNGAMNGMADASLQNKAVETILEHYTDIFVDDGEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYG8</accession>
    <name>A0A4Q9NYG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1039199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYG8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NYG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="446" mass="49232" checksum="BB5CA76F6A7A603F" modified="2019-07-31" version="1">MAVTTKQLWENAIAHLHDLSNATLFQKAELEARVAELEAELTAVKSAYSNATDMAALDKKAHNAQLSSLNRQISAFSFPQAQDPFVLCVIDGDKLLFHSSLIEQGANGGRQAAQDFTKAVAQELVQQGLTGFERLSFWVTVYLNKKAVAARLMEEGIARPDQFEAFLVGFGQASPRFVIMDAGPGRESTEGKIKEYVKTFIRVPQTLRLFFGGIDDTYFPMYESLMQEDLAGKLVLLQPPMKPTPLVRQMAVRNIRFEGLFSEESLSPIPMRRPGPGLLGISESNLHPHVITNGGLISPQSETQGSISPPPANRTPEGFKHIDPSKPLHKQNPPPCNEHYLMTCSKGTNCKYSHEWLLNAEQLDVLARNAKKAPCNYLKNGAWSFLAECWHETHNALGLTCPYGDKCCWGHVCPSGARCFHLSKGKCWFKGEGMHPPTSPSPVEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P131</accession>
    <name>A0A4Q9P131_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1038286</name>
        <name evidence="6" type="ORF">BD311DRAFT_729835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3"/>
    <dbReference type="EMBL" id="ML143483">
        <property type="protein sequence ID" value="TBU24280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P131"/>
    <dbReference type="STRING" id="114155.A0A4Q9P131"/>
    <dbReference type="OrthoDB" id="10253554at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05260">
        <property type="entry name" value="GDP_MD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000924">
        <property type="entry name" value="GDP-mannose 4,6 dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715:SF1">
        <property type="entry name" value="GDP-MANNOSE 4,6 DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="GDP-MANNOSE 4,6-DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="5">
        <location>
            <begin position="31"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU24280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="377" mass="42838" checksum="71C9E5598885FEA4" modified="2019-07-31" version="1">MASEPHDVPAPFTTKLSPEQVVEYRKRKVALISGITGQDGSYLAELLLEKGYDVHGIIRRSSSFNTSRLNDLYVDLHERPTHFKLHYGDLTDSTNLVYIIANVRPTEVYNLGAQSHVKVSFEMAEYTGDVDGLGTLRLLDAIRTCGFEKAVRFYQASTSELYGKVVETPQSEKTPFYPRSPYGVAKLYGFWITVNYREAYGMYACNGILFNHESPRRGRTFVTRKITRAVADIHLGKQHALYLGNLDAKRDWGHAKDYVEGMWLMLQQDQPEDFVLATGETHPVREFVEKSFAVLGYTIKWRGSGVGEEGYDEKTGRVLVKVDEKYFRPAEVELLLGDPAKAERLLGWKRKVDFDSLVKEMVNEDLKASSNLIENQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3E4</accession>
    <name>A0A4Q9P3E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3E4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="239" mass="27041" checksum="393523D89CFE1ACB" modified="2019-07-31" version="1">MYTAPLTISERAHKRPRGDGDVAREKEGRLARVAWHAMRTWMKGGGTLGEWDVIILQCPESSLSSGVDPRPREPTTSLPVHVFVRREHPHPLERVLRRRGGWCRCRCVVIWVVLFGCEVAFLPRSVVLLGARGLAVGERHEAPVAACVGVDRVRLVHRFELRNAEFDRRDGAELEVLRHQALHVRPEGLPRPEPERHLADVVVGVDVLRDVLMVDLQGHHPERVCGREGTAVRGRRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5X1</accession>
    <name>A0A4Q9P5X1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5X1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="355" mass="38740" checksum="6FCB68FA02E54421" modified="2019-07-31" version="1">MFVKPNDALNTIVEKVVIKSFVVWYDNTSPTRNKEIAIKEMFEASQFITEHKGSIAKDDFDSLKGLSDSFCEANEATTTRWRDLVKHPISTYNDARKLRSMSNRLMNAARTASGRGRIEAAARESAERHAAEACGTGVAKSSHDTQSPRKHPNAATIAPAGGAVLTADSLHPGSPQTMKSRHVPAAAQAGAPLRISTPNGHVEFPDNIGMMTATYYQGYSVFKVIPDTQNPAQASEQKTLRRSVSIYSVTQTKRVVTSNRSKKRHTTNSHTSGNESENETEGTDDDVVLDQQTASEELEVVKLTDEEAEAFEDALEDFFDASDEFTVQGFDETSDTPTVDEQVDASDCACSPGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6T6</accession>
    <name>A0A4Q9P6T6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_949008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6T6"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6T6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="568" mass="62635" checksum="BA297389F9A144ED" modified="2019-07-31" version="1">MRLQTNQDSTVEFYTLRGPLLGVPSNTRTRPRLRADSEELLTPVADPIAKLTRECSALRLKLATAERRERNSYNAQPPGYRTAPASARTPPYHTLPLAATAESVLAHREQTRTSHLQGEVVKLAERHRALEKTLREMQDALRMKDREIEMLRAERDRLLAERDEGRAKSRSVSRERSQLSMADDYGMVSGNGRGRGDRHHQRHRDRSRSRRAMRRPDEVPPLPIGPAMAMDAEQYVRAQSMDIFLTKTDGWSGAQIIQAVDDLNAEINQFAAAATESCSFAKRAKAKGALTLTSALENTTPWLGPALSHILAFRDHTQDPILVQLALQASIVTCCARSLSLFCVGFPSKLDALLTRILIHMQTSEPQATSSRWRTLTHRSIRMLYPGLEEYAVTELVTTMLRWSSAVFTLCGSANAPTASDSSLHAQLRRIAEAVYKLARVTREDILSTTFEVLVVDSGTPFEPGKMLNKMREGEHDGDEHGSQIGADVDLVSLNGNGTGAAKANGAHDSGRVLCTTELGLRCVTRRELKGSGGGFAEAGPEGDAFESRLLLPPKVLLDSAMDVIERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7K2</accession>
    <name>A0A4Q9P7K2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin Nup120/160-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_921206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9P7K2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059141">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056548">
        <property type="entry name" value="HEAT_Nup120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021717">
        <property type="entry name" value="Nucleoporin_Nup160"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056536">
        <property type="entry name" value="TPR_NUP160_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21286:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11715">
        <property type="entry name" value="Beta-prop_Nup120_160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23300">
        <property type="entry name" value="HEAT_Nup120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23347">
        <property type="entry name" value="TPR_Nup160_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup120/160 beta-propeller" evidence="4">
        <location>
            <begin position="59"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin nup120-like HEAT repeat" evidence="5">
        <location>
            <begin position="819"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="NUP160 C-terminal TPR" evidence="6">
        <location>
            <begin position="1125"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1374" mass="153322" checksum="B10D488E8E531692" modified="2019-07-31" version="1">MEPSVLVASHLSALFPLAQPIPVYSTQKDIIYLSPRSDSGHPLEHASLSTLFHSPLTGTILLRVTHGGFMLELVSLSSEVPPLRFDFPASILPSPSIVLSQSEELHVLLATRFGSLYRIVIPIREGAPLWQATANRRWYREYVIQTAVDEGLVQVQSTHCVVISLPGGSLLRLEAESLGGDTTDDVWRETRADARSFLHSITSLLHAGPPGSSDIVSISSHPQPTDIGSIWTVSRDRHLRMWTARCGCVAEHVLPSTAPGRSTVASRSSPTPIKPSVLLPPEPQKLLCVFTPSHADDPHVLVFVPTEGSLTSGGFFQLFIVNGDALRSVTVFDASATSVHCHLQDFTVMDDTLYTLWDKQGQSMVEVLVLSWDDSDPTATGGWSSASYAQEAELTPAYLDELLLSPGSAVDKFVEAIMRPGMFSPLTLHTAIARYTDACRSLPPPYPPQLLLSYASVAEQITSVVGCTVQRTKDPRTGAPLDANYWNAFKRDWEGFIARCREIERNGRWPLAIGRGNPEDGALIVERERIASLVGEDLPLRLRRELSSSQPMEKQFDILKILSTMRTRLGPRLMRSLEGRLQEVVRQEIAFPYADIIQDQVRVSNFHEEVDEGLESWIVGRVRSLEHDSGKSIQELARHVLDVIGGLGKEVKREEDDGELLSRPISPEWLKALTASYATTSIHARYEFSLALVVFLFFLADELPQWDPGLLAEIFVVFRGVAMLRYVARQPAGDNATPTTQASGPGPDDEVVAKLRNMHVSASRGARFQPTYSLVHWLANVYGISFSSGLPVSAHRFLDRTGLLQSLSPAYATHLEVVFCERLRQLGYYEVAREVLAWLPRTPAVTYVLGRLWLDEGRYDDAGSAFEVLAGSFGPHSALSIEDREALADVLPSGRIFDTQLEFYLHASDLFKAAISTYHDVFFTQLALSEPGVVEDTTPLWTNVIKGLTDLGQYEDAYAALISAPHERLKRDSISQLLYRMCEENAVDRLMALNFAGLADEVEDALAFKARNADPRIRPFYSRILYTWYVSRGDYRNAALTMYQRARKLEALMGDASAFTELVELQLEAYIVAMNALALVDPKSQWITLPIVTETGNEPRKRRRLSKYIPESKYASGKRDTEAVDLKDMQHEYALLSARAELVRRDPTLLSAGEYALPPASIVVRLAQANRFNTAMATARSLDLDMTDIFSYLVGRCLRLSRNPESVLSEDMSDWLLTDKVSSWPGTPAERGWRYLRQSLERHDGPQTDYRYSKVALETIVSFDRTSPPPPWLIHKLEEHHPEYLIRTCLRYEVLEAALDYTLSMMRRSDSRLTEDMSKTAAATWLPYTLIDQVLVAADTQADLSSRGRASLGELRAEIATRMKRVQKYSQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8B5</accession>
    <name>A0A4Q9P8B5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Transcription elongation factor SPT4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_920989</name>
        <name evidence="15" type="ORF">BD311DRAFT_723811</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 13">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the SPT4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143429">
        <property type="protein sequence ID" value="TBU27729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8B5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P8B5"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.210:FF:000002">
        <property type="entry name" value="Transcription elongation factor SPT4 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025023">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="14">
        <location>
            <begin position="20"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR025023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU27729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU61212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="14184" checksum="441AE40E6C01865C" modified="2019-07-31" version="1">MSSQDRPSASIPSQPRAKQLRACLLCSIIQTPADFRKHGCPNCEELMQMKGYPDRIQACTTTHFEGVIAVIDPDNSWVARWQRTSKYVRGMYAVRVKGRVPEDVEAELESRNIRYRPRDGTDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9U0</accession>
    <name>A0A4Q9P9U0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_910676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145323">
        <property type="protein sequence ID" value="TBU51429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9U0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19401" checksum="6271A2827AFE11FE" modified="2019-07-31" version="1">MVLSTTDVSSRASLVWNNIEGYGYYGLYRVQTAPKNALAGQHATAHRVARTQPPTARHRLDLINMDVCPAYISDPRIRSSWSEYPPYVRQALLGNISTNEGGTAGTSAHQAATPQAIQTGMPSPQGQPFFAQRSVRDGPRAGGEEERGRTRVQGPQTSSSPRRDSRNTPRTPETSPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAV5</accession>
    <name>A0A4Q9PAV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_279435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145282">
        <property type="protein sequence ID" value="TBU51840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAV5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="40"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="17477" checksum="6801EE140B99E083" modified="2019-07-31" version="1">MRPIASCHPYLFFKQASHTMVSSIVAQTIADEASIRISNYWALSCSAAYIYEYLLTLDREIELFWGRKALVSVLFLLNRYLQLFCIVKQSIAIDTSIYGDSPRYDVQSLDSSLCSYFAFVEMPAACKSMATYRMPSFSRTLLSGPWSLEYEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCX2</accession>
    <name>A0A4Q9PCX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_940193</name>
        <name evidence="7" type="ORF">BD311DRAFT_766887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143484">
        <property type="protein sequence ID" value="TBU24226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145249">
        <property type="protein sequence ID" value="TBU52478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCX2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCX2"/>
    <dbReference type="OMA" id="WYQSKLA"/>
    <dbReference type="OrthoDB" id="430207at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF17">
        <property type="entry name" value="PROTEIN MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU24226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21810" checksum="D6C593C8F1E3B1E8" modified="2019-07-31" version="1">MSRLLHAFNASLIKRPMVTQCATSFVLFATGDILAQQAFEKKGSNHDFARSARVAFYGGAIFGPILTKWLQLLNRLQFTSPTKAVAYKVYLDQFVFTPGVVAMFFGSMTLLEGKTVNDAKVRISEAYVPTLIRNWGVFIPTQIVNFALVPTHLRFVTIGVVSLFWNAYLSSVNAKKQAQISPAYTPEHEKKIAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD73</accession>
    <name>A0A4Q9PD73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">BD310DRAFT_265127</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="ML145272">
        <property type="protein sequence ID" value="TBU52005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD73"/>
    <dbReference type="STRING" id="114155.A0A4Q9PD73"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000099">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU52005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="174" mass="20126" checksum="3B9247F37FDB5410" modified="2019-07-31" version="1">MRAYYHDESNEHPTARHDSTGEYLDLNALKEVGVLAFVNQSLENVDAIALERGYVARDEIRVSKEGLGDGYEAKIKAFYEEHLHEDEEIRYIREGSGYFDVRSKDDSRWIRIHVEKNDLIIVPAGIYHRFTLDSKNAVRAVRLFKEAPKWIALPREPGLETNPYRQQYVSSISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDA5</accession>
    <name>A0A4Q9PDA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_862484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145269">
        <property type="protein sequence ID" value="TBU52045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDA5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7998" checksum="3CC8332FD893F0D0" modified="2019-07-31" version="1">MRRPEREVLVVAFGATRRWEIRYVETEQKGQIRMSAERRFARIPHSERYNTMVECWRRCVTAIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDT4</accession>
    <name>A0A4Q9PDT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_182142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDT4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020491950" evidence="1">
        <location>
            <begin position="23"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="192" mass="22171" checksum="5FF0055DC13A1606" modified="2019-07-31" version="1">MVRCLLIKCFLVIMHKWQYAHPDMMASEEVEFRAAICVPPRLVQGYTLDSHAMSSALFSEELCLTGGRRRWVDHMLSCPDLVAVISRNRYGILLFIQSVYPKKSALKYRSAPVYQSSYARPITIRLLEDQKAPPTLVKREVTTEVVLVLSAPWERPRLPYHHACPYTPTLLRLQQRFLSPGDQRPRFDVPCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDU1</accession>
    <name>A0A4Q9PDU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_888431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDU1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="24306" checksum="319E519E2C948F25" modified="2019-07-31" version="1">MAARSLTYRRDRVQEVLSEVARRLSDDILLDVLIEKVHAAMIEVRIRYSPRSKDFIREAVHAEVRARRVSLHNNETICKITLTPEGKRFYRKMGGSTLFNAQDKRLMRLTVKELREQTELIHRVVREIKHLFTHFHPESAPYPPNDIPGAMRLMFRHIDELNEQWTDLQRDLAADQATMRDLRAARRSSGHAGSASTGSGSMTSAFGGSGPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEH6</accession>
    <name>A0A4Q9PEH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Osmotin thaumatin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_940164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145248">
        <property type="protein sequence ID" value="TBU52515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEH6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEH6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020667137" evidence="2">
        <location>
            <begin position="20"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="28"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="96"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="149"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="154"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="255" mass="26636" checksum="66794C69D6EEC667" modified="2019-07-31" version="1">MKSFVAAAATLAFATTATARTFTVVNKCSYTIWPGLFTDLNVGTAVPDQPTGWEQPSGQTVTFTVPDNWKAGRIWGRRDCDFSTNPGPNSCADGGCNGGLECDAHTGTGVPPATVAEFTFQGDGNQDWYDVSLVDGFNIPIRVDNDKGCSVADCPVDLNANCPAELAGPTDSSGTVVGCKSACVAGLGDQTNNPNCCTGTHNTAATCPPSGVQDYSYFKNNCPNSYAYAYDESSGTALWTCDSGLAADYTITFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFP2</accession>
    <name>A0A4Q9PFP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_981413</name>
        <name evidence="2" type="ORF">BD311DRAFT_812372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143617">
        <property type="protein sequence ID" value="TBU21380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFP2"/>
    <dbReference type="OrthoDB" id="3049768at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="37909" checksum="79DFD1E0B1E86FDF" modified="2019-07-31" version="1">MSNSAENRLPPGWIQAYHEGADQSQCRPALQHLGISLPSHIHQFRTRTEPSPNQARLPLAESRVHRFTPEHPSSDPSPAQSPEPEDLIPAPQAGPGPQRFSALELQQIVAVTTANNPFLAEHGRKAKAWAKVAAELHSQHLCLNSTADSIKHKVKKLIEYHENPNPRSGIARALAEHPSIEALMPAKLDQPTGLRDGATHVDEGKRAKARKEEDEKTAQGAYIRNLAMRSMGSRAGAEASSSETDAPSSNDEYKENQRLKKCKREEPALYVRRSKKQRLDKTPSGQLLQVIKDVRGEERRERQQRDDRLINIFEKTCEAQCIAQRELVEILTSSLKQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG48</accession>
    <name>A0A4Q9PG48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chitin synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_942307</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145335">
        <property type="protein sequence ID" value="TBU51356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG48"/>
    <dbReference type="STRING" id="114155.A0A4Q9PG48"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14024" checksum="08FDB9DC812886F3" modified="2019-07-31" version="1">MGNSLEDWKRTPTTTAVLFGIDLPYRPPKNAVGAFLWRQRLWIETTCGLSLLEPWEKILTLAILYLTLTVVFTGLYTFLPQELPLLYGRTLYYFLGNEESEAAALSVRRLVGGWVARNASVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGA9</accession>
    <name>A0A4Q9PGA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_784738</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145262">
        <property type="protein sequence ID" value="TBU52202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGA9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGA9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="569" mass="64069" checksum="6DC62EEE21DBA4D3" modified="2019-07-31" version="1" fragment="single">MEDHPQQRPAKRFKHESYKDTLKSVHLPSALDQTKFDQELTDTDSHFHEALLHWQDLNLAPAFLKFARDADPLSASMPLLLHNWKEILEQWFEALAKSDDEGLRAILDLFQKLAHDLRTTLAPEYPRVLRRLLKLLPRSLSAEALTALLATFSALFKYVLVPSVDSELLQQAWNAFCEVLPQCHPEVQRATAEVWGAVLRRLKVALREGAVRVVASSSTGGLGDVCAWTFVTACKSVSQTLHTVTSSLVCPLLQFYLTCDAEEEAYTLIRRVFTALIHHCKSADQFSPVSEAIVDRFAEVVKSADEERVRRVLEAISMVCSVRQGSRMSHKQLSALLSEYPSIPTSEVLHSALLKFATSALTAGDMSLWMAHARKVLAHAWERPLLGIELTGALSELSWGGWKLVALPYVSANTHKLLESHSGETLELLAALHREKRLGEMDLVWKQRLWTWVEKRLEGWERSEENARVLAHVLALADLLPSLPKLLVNIIDRELALWEDSEHDPRAEYEATYANSAWVIGACAQCIAERPVKEWGSLVDLPRWAGRVVEKWGWSGTALEGLAELVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHP5</accession>
    <name>A0A4Q9PHP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_938133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145215">
        <property type="protein sequence ID" value="TBU53407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHP5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="21625" checksum="5ADB89F61FE041EF" modified="2019-07-31" version="1">MHKASSPTLPSSVQHRSLHRGSGTLLTRHDQGERSPQPWPTNSTSRTMLDTHHRQTKVRLSIPQPPPWPQPQLHLQRRQLRRCHPMNRVSDLPHDLHEVQVTNRHLQHARPRIRQTERKRSRRAHHGHAINDDLDNPTPEPGNVQVRERASELFHAAVIQRRTSPGGSVDAGRGGGILLGSRHARPGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI98</accession>
    <name>A0A4Q9PI98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145228">
        <property type="protein sequence ID" value="TBU53006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI98"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9201" checksum="76E9230C281E2E7D" modified="2019-07-31" version="1">MPSGGAPDDLGRTSLPTYRRDMSRVAAHWPGPYCDHTAGILQKKLFKTYFGHSGSCIRMDSWEPTAPRHMIERLSSTYTGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIN1</accession>
    <name>A0A4Q9PIN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_887053</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="518" mass="59816" checksum="02AFBE26DEFB4D90" modified="2019-07-31" version="1">MAKQLPTELWYRIIQFLPPQDQKTCLSVSKLHHDIAQKYVFSHIIITLGLWRRDDDISHGIDFGLTPAPIEVAEASRLAKLNYALLRHITRTPEFARLVKKLTVRAYSLFEESPLVYEISTLAEAIEALHNLSAFAWFGPLPKLPCEVMDALLRSSGQRVVDFIIHPEFPEDLCLPSFTQVQSLVFRHRFLDLWPQMHVGAPYHKTVHRTIAANSATLRRLEVFGDALWECLPMSFASLHELAIVFPCTLAGLGSVFEHCRELRGFTLCTENDGSEIIDVLNIHQDAFPHLTSFKLLSVFDLDEDVIEEVAKFLKKKRRLRRVDVLSRTQVDQGEDLINMSFLKILRDLPNLEILGLDIRPAKMTSAHVKLLEQYVPPQVTALSILFHANTSDVKVVDWRSFFSKHEALRYLHIGTRQPLTRSLGNAIFRRPPPNLELLGYNNGLRWVTHDPKTRAPKYSEFWPASKVYFRSVEEYQGHEDWEWLLRHHGQDDDDCDIWSMDPPDLWKRMDSSDKDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJN0</accession>
    <name>A0A4Q9PJN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_79620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJN0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="13054" checksum="3C420C805F4E6442" modified="2019-07-31" version="1">MWMRSEGVKKLLERSFLCSQPVQTARRVRVSSDRSHRKCLASSCSVLGFVTAHRRHPTLAGIAIHLLHRAVSSDARKPVNASPVRTVHLSQLRRFVRSVEATSSIITYQARYNSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJZ4</accession>
    <name>A0A4Q9PJZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_908942</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145189">
        <property type="protein sequence ID" value="TBU54443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="21149" checksum="84C129B4736A2F04" modified="2019-07-31" version="1">MPTVPRQTLTIPDEMITYLSDHLNLDNIIRCPVIVRKDSHHLHFHTPQIRVPETHPFGPIPPPDTPCWLILPSKLEPGWTLPKNVHFLGRVLRVAEYQESRVIMLVQHIQSPAILSLAVPYEYFVGDTSSWWAQVVWNVVSRVKILQKPDNKDYLPGEPHCVSLDPITNDWEINDEVQATYSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK39</accession>
    <name>A0A4Q9PK39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_935883</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK39"/>
    <dbReference type="STRING" id="114155.A0A4Q9PK39"/>
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    <sequence length="649" mass="70018" checksum="0ECFEFAFF64A57FA" modified="2019-07-31" version="1">MRPASLTWATLVLASLAAAAPSISRRNNLVVHERRAQEPRDWVLTRRLEPSAVLPMRFGLTQSNLDKVEEMLMAVSHPDSPTYGQHYSVKEVVDTFAPSAETVERVVEWLTESGIDTERLRLSKSKGWIEVDTTAEEAEALIDAEYHVYTHVETGAQQIGCHSYSVPEDIREHIDLIKPTVHFLHRVPTPDQVQTDNLMRKRSLERPSTHIKLGSKVKADGTSVNLPPSLANCDEIITLDCLRALYSIDRKPTETKKNTFGILEFTPQAFLQSDLDMFFANFSPSQVGKKPTLISIDGGVDQTNMTGFDFNGESDLDLQYAFGLTDPQPILLLQTGDLVEGASFNNWLDAVDASFCTFEGGDDPNFDGIYPDTLPGGFDKPESCGILKPPFVVSTSYGSDEASVTRAYAQRQCTEYAKLGLLGTTVLYSSGDNGVAGNGGVCLDGNGNPVTNGTGIQFNPDFPVTCPFVTGVGATQVNPGSTVNDPEGACEQVIFSGGGFSNFFEMPQYQAAAVKSFLTNHPPPFSGEQFNNSGVARGFPDLSANGANYVVAVAGEFELVFGTSCSSPVVGSMITLINDARLAAGKGPVGFINPAIYTEKFQAAFHDITMGGNQGCGTPGFTSTEGWDPVTGVGTPNFSRLLPLFLELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKN4</accession>
    <name>A0A4Q9PKN4_9APHY</name>
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    </gene>
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        </lineage>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="TBU54656.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL27</accession>
    <name>A0A4Q9PL27_9APHY</name>
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        <submittedName>
            <fullName evidence="4">Oxidoreductase</fullName>
        </submittedName>
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    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 464.89</strain>
        </source>
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    </comment>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="287" mass="30769" checksum="4CB8BCA0168DE415" modified="2019-07-31" version="1">MSSTQKIVLVTGCSQGGIGAALCEEYASKGCKVYATARRLEAMHGFTHGSIELLQLDVTNQNSIDAVVNQIIEKDGRIDILVNNAGMTCSGPVVEVELDRLQKTFDTNVFGIVRVCRAVIPYVAARKSGTIVNMGSILAHVALPFAGIYSASKAAVHSITEALYMECLPFDISVVLVDSGGAASNIINNMAQNVGVPTLRIYGDYVDVIREDFNPDRPEVKAATPLDEYARGVVKPTLEAKPPRSFGVGSGSTLVPFIASVVPRGVLLRYLWQSLVEKKRVALAKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLH9</accession>
    <name>A0A4Q9PLH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_716867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="359" mass="37912" checksum="15BFB9EF0879CDE9" modified="2019-07-31" version="1">MNMLKPPFPTPPSSGTIPYDGSYTMSPPIVGSASLESSPATSTGHEFPQNQGRRPSLPQIFDTPPHPVHSHSMSSSLAQGSNRHHGKSSGRPSFSSSRRPRSAGTDADTSSSTPGRLRGKLSLLSMFKKSAGETRPPQPVRGLRGVRLRRRDSGTASGIRAWTLQIIVTATIRSSQSRDNLLGIHGFDNRARGDSFGSMSTSTDASLPQTPGPGPVLGLDIRSPGAGSLDLPSEQEENSMLEGGRSRADSTASRTNYLIERERQQHRARTMSPPRSRAPALDIDIRAISSHAQAEALVQRAQKSIIDMEDVDIELPGLGLVGSNPGAIVGIGPGNGGTLSVGRTPLSAKLGQSDHTQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLI5</accession>
    <name>A0A4Q9PLI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Quinon protein alcohol dehydrogenase-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_885096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLI5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLI5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="405"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="448"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="652"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="694"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="539"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="738" mass="82107" checksum="E4426D775D1D3B67" modified="2019-07-31" version="1">MNSTGDGRFTQPIMFASPRLAWELIERIISHSGDDRRTLYSFSLTCHQLRPRSLCLMVADVDIMDRAQVITFRDFLEAYPHFCPFVYSIKADPTTFMPFPLLYILPNLTNTQWSSPATPQPLGGLSLPLPLLTCCHKFGTNITSLSLVSLSSKTTQELCRVLLAFTAIKDLRCERLGIGGTVANGAVLEQRLRSQRLKLRNINIGYNVHETATKFLFDSAQSTVEILSLDITYSIISGPSALLCGKWPELLTLTLTVSTNQDRFEALIKISKEFHPSRLNEVSVELRSTVGDLLSWIGSDEGNLHLCSELDQTLLSYRHPQLLPFGHRRTRSGRKDLWSEEFAKYFPKLTERGLLKIASSADIALGHDDLVTALVYSPDGSRLATASRDCTIILWDSDGQLVHEWVAHTGSVRSLAFSPDSRHLASGSWDRMIAIWDVGQGSRKITTLKGHTEQVEHCAWSPDGTLIVSGSWDNTVRLWDTRTFQQLHLLDISTNDFYHAYFSFDGRWLILIGSHRCRVWDVGRGAMHINFRIAEGEETEDKAAIDEENEEDKGEGDEEDKDEKDEKDEDARPQCCAAALNLQGTCLATGYVDGSVRIWDVQTGQCLVFSRMHTRRVTVVAFSSDGTRILSTSWGDTPKILDTYSGTMILSLEGHTGGVGAACFSPCGKYVASASSDETVRLWRTDDGSCMGIFSEHKDAVWLSAFSPDGKTLSSGANDGSVVMRHIRDIIPVEDTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PML7</accession>
    <name>A0A4Q9PML7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_687378</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML145169">
        <property type="protein sequence ID" value="TBU55405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PML7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PML7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="37994" checksum="8E9A8BA293E3D6AF" modified="2019-07-31" version="1">MPKATDRTFTNKLHAIWAVEPQAGEEPHPGTFKYEQTRFEQGFIVHHYAGRVEYRTDGWLEKNKDPLNDNLTRVLAASSERYVASLFAQYSDMPLPTGTNALHAATIGKKRVTKKGAFRTVAQRHKEQLSALMTQLQGTQPHFVRCIVPNTLKKPGRVDVPLVLDQLRCNGVLEGIRIARLGYPNRLPFVEFRQRYEVLTPGIIPPGYMDGRKACLRMADALELDKSIFRIGTSKIFFKAGVLAELEERRDALLFDVFSRLQAVARKFTARRQMKKILNRAVAIRTIQRNARIYGELRDWPWWNLYPKGRRRFGRAASNSDCGLVLGSTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMZ1</accession>
    <name>A0A4Q9PMZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_825615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMZ1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMZ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="10"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17808" checksum="F49B1FF989D1031A" modified="2019-07-31" version="1">MLVVHPSSQCDVCLDAYTWSTPTKSPHAIQCGHIFCYDCLRTVNPSNCPMCRKAFNPERIKKLHVDKAPGEGSVPTGPMAEENELLRRVGMLFDQDADPVDIDAIVEEATEWLNNHPGPAVSHPALIFPVATRDVRKIDLTWHRLFSARCVAARYVRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN91</accession>
    <name>A0A4Q9PN91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_933244</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN91"/>
    <dbReference type="STRING" id="114155.A0A4Q9PN91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="493"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="4">
        <location>
            <begin position="702"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="939"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="416"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="943"/>
            <end position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1149" mass="130019" checksum="225522917E7F8C72" modified="2019-07-31" version="1">MEPATNGTTQTKVDEEQARRAKRAALKELNVHHAGLEPAKALDSSLKRHTALIKRMRQSVGLENREHILKDIESLSLEKYVDEIVGAVAEGIMRCKTEKDVWSAVEIISALHRRFPKTFTPGIISSVTTAIAPPSRALLATLTPEQREKEDSARVARQRPVLRVCAELALVGIIRDGPERSGGEWIMKAVRDLLSNDPSLSSLPLLLAFLKSYSRPYLGIVPPQASKQISASSEPGTLSEAASEEAQTNGSSPTLINESEELVEKEIRDRFKKMCEGYFDNVAKKLVIEHNRLQDQDRKNHEAYIRSGEIFEDRQQAYEKMTKSYEKLIGSCQSLSEQLYLPMPTLKSASQKSESIQIGMNTGSSLLGGDSEELSSGGGKWEDEEERRFFEEIPDLKDYVPWSVLGLEGDGDGDNEDGREKERKEKERVQEEVRRLEEELAEMKVGEDGTALPNGKAEKEVEEEDADDVPTPTPGTPKESPSTTPQLAPQGPSQLLTALLARLPDATNRSLIDQAAVDFAFLNSKAARKRLIRFMSQIPRNRTDLLPHYSRLIAILNRYMPDIGTEIVASLDEEFRYLQRKKNVVKELVEVRMRNITFLSNLTKFRVVPPHVILHMFKVCLDDFSGTNVENLAMLLEGCGRFLLRSEDTREPFSKMIELMRRKQSMQHFDQRQLLLLENAYYQCNPPERAARQVKERTPMELFIRHLIYDVLAKKTIDKVLKLLRKLDWADAVVQRTLHKVFTKPWKIKYSHISLLAMLTYDLQRYHPAFSIGVVDQVLEDIRRGLESNLYNMNQRRIASVKFLGELYIYRLISSGIIFDTLWTLVTFGHPDGRPLPGQPSPVDMPDDFFRIRLVCVLLDTCGMCFDRGSQQKKLDNFLTFFQLYVHCKNPLPMDVEFMLNDSLEAVRPKLVQFRNFEEASSAVDEMFNVALQNAGIARDIGDADNDSGEESGGEDDDEDKERRGGEEEEEDDQTQPDSPIDERAPSPEAVLLKSSSTLEHLGPTEEDDAEFAKELAKLVTDTSADSRKVDKKTALALLDTALPPPVVRKKRNEDIDEDEAGAESARDPSVMNFTLFTKRGNKQQTRQIAIPAESALAVQTRTAQMQDKVEQQHLKRLVLNYEQREEAEELKALESRSRQGPIKIRLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNB0</accession>
    <name>A0A4Q9PNB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-xylanase</fullName>
            <ecNumber evidence="12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_933288</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="12"/>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020509929" description="Beta-xylanase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="14">
        <location>
            <begin position="36"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU55654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="37652" checksum="7B5D8CA31CC3CB56" modified="2019-07-31" version="1">MQISTFFAVLGWVLSTVAIPASPTVEAALPTSTANVAGLHALAKAAGKLYFGTATDNPELTDQPYVAILNNTQMFGQITAANSMKWDATEPEQGVFTFTQGDQIAALATNDGRLLRGHNCVWHEQLPSWVTSGTFTAAEVTSIIETHCSTLVGHYKGKVYSWDVVNEPFNDDGTFGQDVFFNALGEDYIAIALRAAKAADPNAKVYINDFNIEGTGVKATAMKNLITSLKSQGVPIDGVGLQCHFIVGEVPTTLEENMREFAALGVEVAITELDVRMTLPETAALLEQQKADYQTVISACQAVPQCVGITVWDFTDKFSWVPGAFAGQGGACPWDENLVRKPAFDGIVAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNJ0</accession>
    <name>A0A4Q9PNJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_883748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNJ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNJ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005732">
        <property type="entry name" value="PRK07550.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="36"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU55744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="418" mass="46140" checksum="23AA5F0521C05AD9" modified="2019-07-31" version="1">MVRYRLSNATLATGRPPIPQAYQWADAYQATHDRPLLDMSQGVPGVPPPQSFLEALGAAASSPGSCGYLPNVGEPSLRTVMAQEINIRYGPDADVTQDDIAITAGCNLAFVAAVTTLADSGDEVILPVPWYFNHEMTMTMLGIKPVLLHTFAKEGFLPSPERCAALITSKTKAVVLVSPNNPTGAVYPPSLIAAFAKLAHKYNIAFVLDETYRDFIINGVPHRLFSRPTTSLEGELPQDWEWRSTFIHLFSFSKSYCIPGHRVGLVCASPNVIPSLNKVLDNIQICAPRPPQIALATVVPSLRSFVRETAEAVAHRHKLFRERLPLRWKIGSQGGYYAFVRHPFAGVHANEVCKRLAQELGVITLPAGFFGPKREENATVMDEDRWIRFSVANVDDEKVEQVCQRLAESESEFGWNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ01</accession>
    <name>A0A4Q9PQ01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_612711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PQ01"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="957"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1365" mass="153847" checksum="BF34E5B179A8C598" modified="2019-07-31" version="1">MTTLLTPISEQNVGPLPPNIDEDVEPDAQWKESLRARIEQTLQPMVDKAREDRDAQLRGVHEGTLQWENVMKSYNYAMDRVRRLAQDQFTEELKIARFERSLALGKEVEGQEFEEFKRRQQAIWDTIKKGGAERQQGPAGRRDSSVSNSNQENGEPVASLPRANEDPAAVPLRATGEQDAREGPSTSHREPRPLARGPFGPDARPRDRTQSGGSEQIAGTPGSYSARPARSRGNSSVFADFDPTNTNASPSPYDQGSIGRGGVSSLSKTRPQNIWLPPTSTRDDLPSTSTSRTFAHAAAPTVSPVSPNTRENPSNDHGRTVSRAGSFRASDRPSPIADFESAPIPRDRFGLPVDDRTSSHKGKEPERPERSRQPSFTQQTLVHDIYARRPDPRVQMPVLVPSARPPPAPQPPEDQQAFAQVSPQNARHRTNGFEDGEGIPIRAARRSNTSDQGSPEHMRYGPQKPASARPIPSSRRSLPGETDAWSAQPSPPAHHLFGPQSPPSVPTASSSRPIPRPSSADDDPRRHSPSGAWHGSQSPPNVLPFAGYDLPFSSSPRYRGYAGSPAGSVSGRRNSNGNGSRSVRSHSSRQEFWGPSDVSQRPLATFEEQSVASGSDSEEDYGVDLDDLWHLRERAELRERHQLTWKLVRDQEREEVMRKAAEAKRLEEEARRKEEEARRKEEEARRKEEEARRKADEARRKEEEVRLKALEIQQKQEELARREAELLRREMEAKLQEERRKREELEAALQQMREAEERRRQEEAERQEREMREREERERREKKEKEEREERERRARRPNARDASGRSRSFGRRKNASARRRRNEIGRTASGGNGRRRSERRNASAGRRRSANGRSGSAHRRSGSRERGRLGRKLAGEMRKPPRPRLRKLDSRPSGYKPSVSPHSRLRDSKRTQRGDNERQRLRGYEKKLNVARPRPNDNESFGSSSRKRPKPKRSDSSQPRNNSNRQTRSNSDEVPMSCGRRRRKHDDGGSRAGGSNGRLKSDGRGPWPSRERQRQRASNAKWRRLGSNVRRRKQDSARWTQRQRGCVSRKPLKRSVCAKMPNPSQTMSSPSSRILISSASKKRSSRASKLTVSARPANALPGNARKKRPGSASSPGSARRRMPGNRPRSFGSRKRRTGEHRRRTRGVRGSSKPVGAPRMPCDGRRNSRSSSLTQYSRRLYVAQRRSISSSNSSSNNNRRSVDGGRIAWAVYLIPVPAVPGRTILQALRPPLDPYPTQARPSTTVRLLQATVVARHRPRASAVLQVSSPLRQGGPTPPVTPVPRVGLLLHQPPARLRSVRQGRQAPAVLGNLLYPPLLLSRPRLPRRQAADLRLVPIRPLIVPVRIPSHRTAHRDLLHPIRPMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQU2</accession>
    <name>A0A4Q9PQU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_823118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQU2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="71"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="23048" checksum="52A98CC3FACDB495" modified="2019-07-31" version="1">MPPSEDLGHSTLIRYISYNLIARPPAPRIYTFSSWSNDSMFLLPSRDVDRTLTPIYNITVALNLNPFVPLSYVTTVRRGMDEQGELIGEFELAVMHSRAILKMGNHSTRMSNVLKKDGHSSRKFVWVYGDVELRWDCRTTLEDGSPMCICTDRGSHQVASFVPPPLEASPPPPAATLTVFPDGHELFDHILISALVVERKMTLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS82</accession>
    <name>A0A4Q9PS82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Organic solute transporter Ostalpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_929707</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PS82"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
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        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
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            <begin position="234"/>
            <end position="254"/>
        </location>
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            <begin position="496"/>
            <end position="529"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="557"/>
            <end position="650"/>
        </location>
    </feature>
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        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
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        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="626"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="740" mass="81993" checksum="B3FDC36C3B0F335C" modified="2019-07-31" version="1">MKNTATVSTTMFPKLGHGSGSALPLPILLVAGVCTGIATFVSVISIVLHLKNYRKPHLQRQVVRIMLMVPLYAIASFISLFSLQAAFFIDAVRDIYEAFVIYCFFDLLIAYLGGERSLLILLHGRPPKYPVFPGNLVWREVDVSDPHTFLFLKRGVIQYVQLKPLLAIATIVLKALGKYNEGDLAAGSGYLYISIVYNFSICLALYCLAIFWMCVNDDLKPFRPMPKFLCVKGILFFSFWQSIFISILVAGGAIKKLGPYTDSEHISLGLTDTLICFEMPLFAIAHMYAFATRDYVDPHASYVARLPVFYAFKDAFGLKDVVEDVKTTLRGEGMDYREFEPSEGHIHQGAGRDRRIRAGLRYSQGGKRKYWLPQPATSAVRPGPRIPANNGDSFDEVHAPLLPDQEAEVVHTAAGLRSPDEGFSLFASSGLADEGYGLPFDDVDEADEELFEHSKKYLFGDYNYPCVDVSSERARKTMWIEEERILRDEHSAWYSPLNGPRRHPGGYGATGNTEQLHPDNGKGKIRGSGPEIIIDKETERLSPPPGHGEVQLRWTSAKATPVHSPPALQSPVQRAQGALSRTSSASPHTPVSSSSKGSPRNLPPPSPRSDSERPVLPPDAVDLVVEDPHAAEEEMTHERRKGEPAVRGGGALHRVYRRGYVVEEDGRREEGEVQVDPASAPFPWRGHGVFDVGEEEEDPEEVLEAEQRVAEATARTVVRAETPPSHVHVVVDVPEDNPWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT99</accession>
    <name>A0A4Q9PT99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_929046</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="26245" checksum="9A387A50CBBCEEA6" modified="2019-07-31" version="1">MSSNKLRKPRHESRTMALARQMVGSADNNNRIISHGGIASWDEHLIEVRSTTALSHKSPVGYRGRMRSADSPPQTSIQDYLSALLHPVSAIEQYWAMRAARAEALLNAHERYKRELDDVSVSHEQRRSRELAELNARYAREYAHVTRMVWICLGALTIAVCVLFYVVIRYAPRVSSDPSRSSAVHYTIPILSPFSSVIEHETSAVNVPLVAVLLIIMGLFGFLWFRCCALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTM5</accession>
    <name>A0A4Q9PTM5_9APHY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12284" checksum="C2D6BD01406E6320" modified="2019-07-31" version="1">MSSYPTNIRSVIEQITSQTVPPTLAHATPKRHSSTQRQRCSTVQWRSSSREGLLLTCSDLDAVCHISGLQIELQRWAFMHDGEDAVPRTSAASSSSPRSSSVLALYIKIQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUE2</accession>
    <name>A0A4Q9PUE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_977641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
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        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
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        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020683350" evidence="1">
        <location>
            <begin position="22"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="37880" checksum="EF64C7B6E258483E" modified="2019-07-31" version="1">MKLFSTASLLYALGAVGLVAAALPKDVPLRLSQGFWHARFSVGPQNFSLTVDTGSFAVLISEGLYKPNPTSVQTNQGEFIQFNGANEDGTLFASETFTFVKDNVTFDDVALAGFLVGNITDGDPLDEDGIIGFSPPASEITDPNDPTFLAGQSLAQAICDQENISPCEFGLALKTDGTGSLIFGPIDESKIKGNLTTQKTLAFDAWWVVNTTEADSPFFVVGDQVVTHIQPIFDNGTPNVIGPLDTVRAALESVGYAIIETTDDNNVTNIFGTYDCSCEPARFGFSFPPSAEVHYIDLGANVLNRTADGKTCTANILGSSMVDAPTWQIGQTWFQGRYVQHNLNTSTIAFAELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUP0</accession>
    <name>A0A4Q9PUP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_487890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="292" mass="31476" checksum="AEFF2061222B7F05" modified="2019-07-31" version="1">MPWARIQLNDGTSIPTLAYGTGRLKNGDSVVGWVKQAITAGFVHLDVAQAYANEEETGKAISESGVPRESLYITTKFSGRDNLTILEAAQQSIKKLGVDHVDLYLIHHPRFATPDIPTAWAQLEKLKADGLTKSLGVSNFNEEELLAILDVAKIKPVANQIMVHPYNLAAQLPVFEFGNKHGIVTEGYSPLQSLRSTPGGPVDKPVNDIAARLSATPEQVLLAWAKSKNIVVITSSRDHGRVVSFLGAGDLELTAEDIAAIDEAGNKGALWSRACSKAGTVLPWEEGKLYDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUT7</accession>
    <name>A0A4Q9PUT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_927697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUT7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUT7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052582">
        <property type="entry name" value="tRNA-DUS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45936:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(20) SYNTHASE [NAD(P)+]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="2">
        <location>
            <begin position="60"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="460" mass="50625" checksum="23B3662C621BE494" modified="2019-07-31" version="1">MFGLHPHLQRIYRPLGFRRFSNMSRRSHPSSPDSSPRTAKRQKREHTPLSPDDYKGGLMLAPMVRSGALPTRLYALKHGAKLVWGPETVDKAILHTTRVVDPVTGVVAYHGKSKPIFTCHPIEKPFLIYQIGSADPELAVQAAKMVQQDVAGFDLNCGCPKPFSTHSGMGAALLTNPDLLCSILTALREAMPPEISISAKIRLLPSQEDTLKLVERIVNTGISCLTVHCRTRNMRMREKAVIERLREIVDFVEKMGKGIAVIENGDCLGYEDSKRVRQVTGAHSVMIATAAEANPTCFSPTPLKDLELTFVPGYIRLGKYLNNHWSSTKFCATQFQGAHDKASRTDLKALREAIVHAKGYEDMEQYVAPWTGEQEFTEIVEAIEKRGGQRAPPMPVPWEDVVVAPLEAIEENGQLKDTEVVARLHEPRSDGAATAPFVRGAVLSLEIPSVGGGGETIAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV74</accession>
    <name>A0A4Q9PV74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_473086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV74"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8738" checksum="1966F8BF760B70EA" modified="2019-07-31" version="1">MLRHPTVLADMVVFSAVARAGVQIVWIRTSSRSQVNVFSRHRPQIVFAMLDANPLPVRSAHLHPASFYRIPDSSCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVR4</accession>
    <name>A0A4Q9PVR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_977109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVR4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVR4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="19986" checksum="9C2FD6B51890C102" modified="2019-07-31" version="1">MTKLGAVSRAETERVSGKVTQVHVHPQDPRLIAVEVDHMDHQVHFYDMREGGFARKPWLEFGYRATPPKANSASPNLNATAARPAVASQASANANASRSASSAPVARSGSRYTRGSTMNSLFARGYGDGAVLVWDYRNGAQKKVLERFQFQRPAEVVHTVLAGSDVIAYGGYTLTFWSMLAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYI3</accession>
    <name>A0A4Q9PYI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_924966</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYI3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="76"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="468" mass="50281" checksum="A15DCB1ED421087B" modified="2019-07-31" version="1">MSATSEIELSSVHARAPHRPEEPVTPAATVEDDAKSLRKSLDNIEAAETERTQSVDIPPTAVPASTPAMRRKARIQFATLCWSLFLAGWNDGTTGPLLPRIQTVYHVNFAVVSLIFVCNCVGFLSGAAANVWLTDRFGFGKVMVLGSLAQVIAYTIEAPAPPFPVFVIAYAINGFGLALQDAGANGFVASLKENAATKMSVLHAVYGVGAFCSPLVATEFAQLHQWSFHFLTSLAVALANTIALIVVFRFKDQDTALAEIGQTVTHQQDAAQENDGDKYRQMFRLKSLHLMAIFILIYVGVEVTLGGWIVTYVKDLRGGGPSAGYISSGFFGGLTLGRVGLLWVNQKVGERRAIFLYAIIAIGLELVVWFVPSLIGGAVAVSFVGLLLGPIYPIVMNHAGRVLPPRLLTGSIGWIAGFGQTGSAFLPFLTGALAQKAGIKSLQPLLVSMMSFMVFLWALVPNSPRRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYT2</accession>
    <name>A0A4Q9PYT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_366621</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYT2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYT2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="137" mass="15256" checksum="1B3D7800505937B8" modified="2019-07-31" version="1">MAVIHTRADPRPSTKEEPLGSFPIIFLFTTCTLCGLFLLWRRASAIRTVVAHRLETWNQGEGRIRLSVDDGPSAREFLDDDYDDDNERLGDSEPLAIRAERLRKAASPAEQAAESVAQRTGLFEADTEEPPPPPPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ17</accession>
    <name>A0A4Q9PZ17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_816118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ17"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020790408" evidence="1">
        <location>
            <begin position="17"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="231"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="565"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="671" mass="71953" checksum="78D499187FF9647E" modified="2019-07-31" version="1">MRVLPQILFFAAAASAAVPYQQYILAPPSRTLRPIAVRLENGTLSTGAALLDNQTSPGQNLTLPTFNSTVTYDFGKNIAGWVNFNTTSSDGAIGFTFTESSLWISSEACDASGGSELDAPLVFNITSAGHYAAPTEKERGAFRYLTVVNLGSDQLSIDDLWVHFTAMPHWEDDALGNYTGWFHSNDEKLNRVWYAGAYTDQLVTIDPTRGNAVIYPASTSSGSSADGFNWYLNTTITNGTSTVTDGAKRDRLVWSGDMSIAVPGIAVTTFDLISVQNALDSLYSLQNPDGMLPYAGIPFNDAGTVSFTYHLYALIGVGNFFHYGGDRSYLDGKWAQWKAGMEWAAAQIDGTGLANVTSSADWLRFGMGGHNIEANSILFYTLNLGVALAQNQNDSATADRWAQLAAGIQAAAIPLLWQPDVGLFRDNETTTLAPQDGNSWAVKSGLVTNASQVVQISNALQGRWGQYGAPAPEAADAVSPFISGFELETHFAANRTTAALTLIRNMWADFMLDDVRMTNSTFIEGYSTSGELHYAPYGDEDARISLAHGWGTGPTSSLTTYVGGIQLVGAAGATWAIVPQVGDLTHVDAGFSTTLGRFSSKWFTDGSVFRLEISTPKGTTGTVGIPFPGNRTTATLICADRPGVRVTADDLGKYWITDLAGGDHQFVVVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ82</accession>
    <name>A0A4Q9PZ82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ82"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="303" mass="34210" checksum="8DDEC25BE4182CD7" modified="2019-07-31" version="1">MQRDYGSARIHLILPGSVNQPPRTFSRLLWTDQRLHPISTHVMSHRSESPTGRVALLMEGVDPERFPNPIAVMASRLHGNVCLLCEKTEPIRACPVIVDRTYYEVRTQIYQSIQPPRQTTDGPFQNTIAWLQLCDSHAAQYKEQVWRFVPANVDDLSSKASIWFDSHSQTRPTGQPLPHESFDLVVFLPKEMEDLDAIFAKHASTCAQTEDAGSRRVLKNFKSIILQPFLAFAATLPMIGGAYVPPPDDHLLSLESACRQVRQQWNDSVQRGSSPGLCRGLEGISDFVRDLRLAKRSQNKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ95</accession>
    <name>A0A4Q9PZ95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_357271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ95"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020456323" evidence="1">
        <location>
            <begin position="24"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="260" mass="27803" checksum="7263112C4463224C" modified="2019-07-31" version="1">MLKPSLFLLSLASIWTYRHHAAAVTIYGQEGVTAVSGAATGTGAAAAATATDWLSALAAFNNVTLTAPALPTSMPSTAFTIPVMNNAQDVQGLSIQQGADFFGFSIEMSVVTQVIGKNASFIQVPFLNLLATVADRAGRVRIRVGGNTQETATLVDSLPDNEMIAKDKTDATNPVRCSSVREDRCGSAGMCWAILAAACVHAVAALLRVACFHGSYVLKLYCGPFHDWGRRFPWFMRNPGLHHDHKIWQPYGCNSGCSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZC8</accession>
    <name>A0A4Q9PZC8_9APHY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BD310DRAFT_923485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZC8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="282" mass="30095" checksum="47267CCBFF91E20D" modified="2019-07-31" version="1">MSSTTSAAPSSSSTGTAGGSGSFLRAGGSTLILAFLAIGLFAGGLLVMFSMRRYVVRNSRRMQARNATSGPLWPWDDTQLGPPPTLLMSIGVRMRRLDDFGKKPELWDISTARSMSKEGDWGRIMPIAARPVYDDRFLSSPYTLGQHTAASGQHPSALTSTSLASPPGYLFPFRIGLRDTRAQIASLRPFRLRHRPGDDAPPSGEADGMPSRVAERVPACVEVALAIALPAQAPCQEGRVPLYALGVTNARWSGESLDLVEDTSESPSGSARTDSDDTARVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZI8</accession>
    <name>A0A4Q9PZI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_876180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZI8"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12761" checksum="DF7F567A05F78A4E" modified="2019-07-31" version="1">MYFLILAVLNSLHLAFTLLSIDVDAFTSISVVTVFTFPLSAILVSRFLLRLQSESLRAVGSIPSSQISSLHLDRSLVFERVVGSLGASIAAEDHLTEDHDDGDNGERADDLNDWWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q078</accession>
    <name>A0A4Q9Q078_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1037940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q078"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q078"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
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    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="221" mass="25540" checksum="65CD715AAE03FB93" modified="2019-07-31" version="1">MSHGKQFTLYTHTGGPNGWKVVNVLEELGLTYEPIYLDFGKNEQKAPEYTKYNPNGRIPTLIDHKNGDFVLWESDAILLYLTDKYDTEKRLTVTDEKEKYSLIKWLFFQSSGQGPYFGQAAWFLRYHPEQVPSAIERYRKETLRVMSVLESVLSKQEWLVGGKPTIADFSFITWNNVALSFTLKDYADVQKEYPAFHAWHQKLVSRDSVKKALATQAALSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0V3</accession>
    <name>A0A4Q9Q0V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0V3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0V3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="397" mass="45895" checksum="9D8B0B239F03CB3A" modified="2019-07-31" version="1">MMTDAEWNSSEDDEYRDARAQTRKSKRRKVIQTRRAKAVAIKVEESTLPQWSLDPLLQALHEQTAQDWENEADRRDSFDEIIETLLPNLLQAGSAFFERDGQDDESSLRTSYFLPRFKVVQLHESNNAESPDSVLACIIHAKSRTHSRLFRRVILERTPSYMASGSLTPLRSSRTIPAVNPEVLDALYAIQTTPYESSFLSRLQGFNLHHQVNAIAVDWETRTPWMDLMTDIREHYSFAHPEREQASESVAPVIYSTLQRCHLDQVHDLLRRVFWEGIDVTDSLDYTPEKCTIVAMYKQLVVGAAFLSSPQETYITYLAVRAGWDNSQIATSMLYHLISLNPHKDITLHVSINNPAMLLYNRFGFKAEEFIVGFYEDYLDAKSPQSKNAFRLRLRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q178</accession>
    <name>A0A4Q9Q178_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_251385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q178"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="248" mass="27191" checksum="731249E82D7B4AA3" modified="2019-07-31" version="1">MDSVPDCEPTGGISAGDGSECGPQPIADRTSFVIVVTARPSSASLAITQPLSAHTYINNIPTWFPCFLLGGRIPSMRIRISWSGRTSVCPHTTPVAREAAYHAFATGAVYSRRPRQGRVRAAQNIVRHGLEAFGGSTRTSDLPPLGQQILGSASHIPTHHVPPNCAAAPLGYRERCKIQRPRRERPSRDRLHTVRQRSPDAWLGESARNSGLAFRTVKETYALTNRSQPRERKTPSVQALETRSGRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1L2</accession>
    <name>A0A4Q9Q1L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SURF4 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_921416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1L2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1L2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045214">
        <property type="entry name" value="Surf1/Surf4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002995">
        <property type="entry name" value="Surf4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23427:SF1">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02077">
        <property type="entry name" value="SURF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="350" mass="39073" checksum="2ACBF2D7A5E08BE1" modified="2019-07-31" version="1">MGRATQRQIHVPTGIGHVAVGARPPLSFSTHRLPLFLHPAMSARINIARPASGGYSPDPHGFANSRPSAGYRAANPDDPVEKIRAFASQVEDYSEIYSQPLKPHLPTIGRFLIVGTFLEDSLRIITQWGDQLWYLQRHRHFPWGISHIFLILNVITMLVGSGAVITKRYTEYAVGGLLGVVIIQALGYGLIFDLNFFLRNLSVIGGLLMVFSDSMYSRKKLFAGLPTLSENDRKKYFLLAGRVLLIFLFIGFILRGQWSIARFFVSIIGLVACIMVAVGFKAKWSAAFLVVTLSIFNVFINNWWSVHSAHPQRDFLKYDFFQTLSIVGGLILLVNMGPGGLSVDEKKKTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q268</accession>
    <name>A0A4Q9Q268_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 4">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_957094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q268"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q268"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="507"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="755"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="755"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="825" mass="91007" checksum="6700CB37FED044A8" modified="2019-07-31" version="1">MPRENRKRGKKHKKSKEEAEPQQDSYVPDFEEQEDAAGPSWIVPARDAPAADLNAPFGYVDAEVKAYFRTVDVQIREWQETKPEVEADEDVDPNEDRRLFFVAALTEMSGKEKQLATDPDCSTILERMVYSMDDFVRRVFMDRLSGSFEQLSKHRFASHVCQTLLTVASETVARESKGILPPTPEEQEDEGELRTLTQLVLDACEELLPSLSSLIMDPFASHVIRALLLLLASDVLSIEDTANSGPGKSAFALRSKKSAAYKARQGSMKSVFENGEQGQGKRTPKEFRKAAFSIVSTLREQLGGNEVRALAANQVASPVLQMLLELEAAYEIADTPGSLMDHALVGMVTAIHENPDTEVPESDYLMTLLRDPTASHLLETLVRRSPDRVFDIMWRTYFAGKLAKLAVHPVANFVVAKAFERLSAEQLDAAVEEVKGVAGKIVKNSRTGVLRALVDRAGAIQSGIQDVVELVVAAFELESEDAKALLVPCILRLKPLPDYQKVVELASREEKEPSEEPRHKRRKTEDPLEPKVPGAVLLQSMLRLPSPHNDVVLHSLQAMSLDDLIQMAHHSTSSRVFDVALESETVPKTAKRKFVLTFIGHYHVLVDDRIGSRVGDRCWASADPYLKEKIARSLIPHEHALAGSFYGKFFARNLNLHVLQRDPERWKSMQATAKQPVPASGSASNPTAASRQPQPKSLGQKPEPGADVPAVTATAQKTDADADRGGGGKRKAKGSRPQDEIDALFDATLGKKVKKAELASVDKIKGKEDVESKSKSKTKDGEKKSKKRKDEEEGAAADKDLSDVLGAIRSAPKDDKGPKKRKRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2J6</accession>
    <name>A0A4Q9Q2J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_995333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2J6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19300" checksum="73B8A7911ECCC994" modified="2019-07-31" version="1" fragment="single">WVFSSLTLPFNPFSSPSTAHSVGDPVRSTSIVSSMRAIPGNSGHLACSPWRLTSTVWCGCQDGSSGRSAPGTSTSPPSRGRTPRRTRHRRLFYMEVAERRRVPPTSPSCATRHQATVKVLSVQRRRHRPSPHPRCPRSLKCGRRGLSSLCPTLCPVDRPVPWTGVLRTACLAYGLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2L8</accession>
    <name>A0A4Q9Q2L8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_975037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2L8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2L8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="948" mass="108124" checksum="BF5BD1BF75F2DC73" modified="2019-07-31" version="1">MLEAEEDIRRKPRVLGDTPDMEYVVLLMLLWSDATQLSSFGSAALWPIYLYFGNLSKYFRGRPTEFMAHHLAYIPVLPDALKDFYMATYGTSPSVDKLKFCKRELFQKIWLLLLDAEFMHTYEHGIVLTCGDGVVRRIFPRIFTYSADYPEKVLIAALRPLANCLCPRCLIPKDKVAQAGTKADERWCNCKRQDTDALRAKILRARKNLFKGYSITGKMVTSWLNAESLTPIQSAFSIRFSAHNVNFYDILAPDLMHEFELGVWKGIFIHLMRILADQGDNAIEEFNGRMRRMPTFGRDRIRRFWHDVSSRKRLAARDYEAFLLTIMPAFEGLLDLRDDQIVSDLLFELANWHALAKLRLHTSVTLDIFRSSTKHMYDAIHKFAENTCPRYQTKELPSEATTRVQRAKVANARAQPSGTRRPIAFKVHHTYKFHALGDFPDYIQRSGPSDNYNTQVGELEHRHVKRFYARTNRITYEIQIAQKERKRSLLASIREKDSFRPLSILKHDRKTAEIASAEAAARALGLSAPAEHHVIPNSQRDGFNIWNFLDDHETDPAIKDFAPLLRQHLVQRLLGADAAPEDGFSDEQTGGVQILDDRLYQHKTICINYTTYDMRREQDTINPRTHADVMLLSSDSNDDTYWYARVLNIFHAHVRYAGPGCTRATQKMQRVEFMWVRWFERDLSYKAGFQHRRLPRLQFLDANDPDNVSFGFVDPDDILRAAYLIPAFEHGGTTELLGPSKLARRLKDDGDDDDDDDWCYLHVCMWATRDIFMRHLGGGVGHRGIGNSIEDSKENATRRSRRGRGRKKAIGARVGNTAQPLPQDDSDESDVVSYASAVEDNARSEQEKGQQPDVGFIGGEDSSEEPDDPDGAGKDMDAQTNTGADFSDHESEMEQRDDTDDEADDSDGEQIDGGDNHQAVVSELEDSEEFNDNGSVDTVYAAEGFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2U5</accession>
    <name>A0A4Q9Q2U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2U5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9609" checksum="61F62EB9A9261559" modified="2019-07-31" version="1">MYMYCSIHIYHIYASLCADRRLSHHIHSCLAFDLIPSSFVHDAIGVRDALYIVGESRPPIDAPFLPSSHHPFLSSVLSATVSLANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3L9</accession>
    <name>A0A4Q9Q3L9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_844956</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3L9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3L9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000161">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1030.10:FF:000002">
        <property type="entry name" value="cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1030.10">
        <property type="entry name" value="Ring Box Chain A, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="10">
        <location>
            <begin position="418"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="250"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="767" mass="88542" checksum="2A6AA5D6FD32DA38" modified="2019-07-31" version="1">MSSAGTNAYPMPPPNADLATTWAYLEEGVDHIMTKLQTGVSYSKYMSLYTVSYNYCTSSKMHGTGDGSGMGHRTGANLMGSDLYNNLIRYFVNHLKTLRTASDTLQDEALLRYYAQEWDRYTTGANYINRLFTYLNRHWVKRERDEGRKGVYPVYTLALVQWKSNFFLHVQSKHQKLAGAILRLIERQRNGETIDQGLVKKVVDSFVSLGLDESDINKVSYEVYREHLETPFLDATQKYYQQESKAFLSENSVADYLKKAEERLREEEDRVERYMNTNTRKALINKCEQVLIREHAELMWDSFQGLLDYDKDEDLQRMYALLSRIPEGLEPLRKRFEEHVKRAGLAAVHKLIGEGSGAQGAPEVDPKAYVDALLEVHQKNSETVTRSFRGEAGFVASLDKACREFGNRNAATGTSTTKSPELLAKHADALLRKNNKMAEEEDLEGALNKVMILFKYIDDKDVFQQFYTTKLSKRLIHGVSASDEAEASMISKLKEACGFEYTNKLQRMFTDMSLSKDLTDNFKERMQQNHDDMDITFSIMVLGTNFWPLNPPTHDFIIPQDILPTYTRFSQYYQQKHSGRKLTWLWNYSKNELRTNYLNQKYILMTSSWQMAVLLQYNNNDTLSLDELINATAISKDILKQVLAVLVKAKILINEETEQYDLNPNFKSKKIRINLNTPIKAEQKAESTDVLKTVDEDRKYVIQATIVRIMKARKTMKNQALIQEVIQQISQRFTPKIPDIKKAIDHLLEKEYIERVEGTRDTFAYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3T6</accession>
    <name>A0A4Q9Q3T6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_153992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3T6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14374" checksum="91BA1FD588F34C1F" modified="2019-07-31" version="1">MTSRPTFASVILLDGAIYFICLFILKFESNIVLFTEPLTSILIWRFMLDLQTVNSGNYPSRLPGCCSRPGVLARRFPCLRAYGRFSGILCHSKSTCRRRRPRTRQYPTAGRPASRTAGTPQSRALAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4F1</accession>
    <name>A0A4Q9Q4F1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TatD DNase family Scn1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_126227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4F1"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="384" mass="43810" checksum="5B529A5DF3622106" modified="2019-07-31" version="1">MESELKEMQARLETVPRSVLEHVIDVHCHPTDSDMAMTLRVAEQMPIRICAMATRRSDQRLVADLARAHPDKVTPCFGYHPWFAHWIALSPVVSKEEHYRALFLPPSPPPKPDLVAAFERLLPYLPDPTPIADILPELRESLETFPNAMLGEVGIDRACRVPYRRPADPPYSEYAPTHGDEDADGPRSLSPFTIPLEHQLGVLEAQLGLAVELGRNVSLHSVKCQAATGEVLDRMYRKHGERWLRISVDLHSCGLSAQTFRDIAKRHPNVFLSLSTVINARSPAHKDLIAACAPDRILVESDFHDVRCSAPYTWHMLQTIAEVKDWRVEDAWDADAPEDRWGAVRRLEENWRAFERGGHRPYVKRRQRRDRAIEEWEAENSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4M9</accession>
    <name>A0A4Q9Q4M9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_919148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4M9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37084" checksum="9B3CA8D0B9F0A574" modified="2019-07-31" version="1">MPSASSSTSISRPTAPRPIPKRAVNTWPGTTASRNHFEDFLREIGACTESTHLCCIPKVTTTHPHVHTSQRSTSNVRSKARSSPSRTTHSRVHLRDASIEESPALTRTKPLPAEGRGRSLSSGRVSGTLTSGLPISPKSPALSSINLENHDATAAYDYFPSAHDHLITVIGHPNLEGRPSRALTRASPKPPQSTSRSPDPQGMSRPSSSSPSSSRSRELEPHSRTRSAGRSSSRTPSIDSLDTASSSEAPATPKTQSMLVHDLPPVSTSPLEELERSSRFRVQCVCMTCKRAGSNFPHCGKCGDMWCSRECRTGAAGTHVCHGRIVRAAQDSRVLQAHPATFVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4X4</accession>
    <name>A0A4Q9Q4X4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_812338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4X4"/>
    <dbReference type="OMA" id="IRYMEYL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="28"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="193" mass="21942" checksum="669A13F70DAE2100" modified="2019-07-31" version="1">MSIPDAAGIIAIRDAGYTATLMTAGVGAWVGYDYLLTVGRESRLFWRRKVNAASILFYTNRYLALFYYVALAYYRIISFPFPYDVDIGIRYMEYLPWAVFSALRVYALSHKNWALSVFTFFCSVIALPLNYYATTPSFLSLIVVIRGGQIIADAIVIGVTWKATYQARSERSMSYLMTVMFKNGKCTVRLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5D1</accession>
    <name>A0A4Q9Q5D1_9APHY</name>
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        <recommendedName>
            <fullName evidence="2">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919941</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5D1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5D1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800">
        <property type="entry name" value="C2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47800:SF5">
        <property type="entry name" value="FER-1-LIKE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="595" mass="65889" checksum="AAAD387A0C91235E" modified="2019-07-31" version="1">MSSSSEARYTCEIVFHRATNVPVADLNDLSSDPYVNATLTPLHNLTGDAGSPSVQSLSFRSQTSRKTLNPTFTNARWLVSGIPASGFALTLWLMDEDPGDHDDKLGRTVIPIPGSEGSVLREGWDTGEREHKIHKRHGGLRTRMNTYLARMFTRGRVRHQVRVYVSVRVLGPAPRLEGDNANRIYTLGPHIFVRHFSLLAARLASVQSLKATRLQLIGPVPSALRHRYVGFKPFVKAMFRAKGIEGMALHRALHQQHSAIYKWDKDTIWGVVEEQPGLEGEDKGRKGGDDVHFAGKVGPNNEKPDEAFARKFLDLVEYGTEGRVFTYVIMLDGQWRFTETGDEFAVQFLSKHTMHSDVSIEIAYSGEFFVRRMRETNAPRQPQPNGHTNGDAHHLDTHGVIEDDPDQDDGPSDEHASQPQDDRADPSSLPPSAYELVIDNDSGTYRPRKDLLPVLEAFLARPSNLGALGRVRALDGFDDRLKRWKEERKEEKRQARGAGTGTTAGKGKGKGKTQEVPVLRPASVSSSSSGSSSHDAGAIEAAAGDAANERAKVEEQEQQVQKAMEEDAKRAQDNQDQDPAAKEEEKEDAEPKTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5I6</accession>
    <name>A0A4Q9Q5I6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_965199</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5I6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5I6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="132" mass="15056" checksum="DF9FE56B7A3703C9" modified="2019-07-31" version="1">MFTIPPSDDVVEEEARELSRDERVHVLKLTTMWGFARRIAVDGLTPLPQKEDSVGWITLARTYDVCERLWPALQTLARRTKVAQPEEVEPLGIITVLETAEIRERFRVPLADRSGGCYGRATYASRETHNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5J9</accession>
    <name>A0A4Q9Q5J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_769935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5J9"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="192" mass="21388" checksum="A14BA79798C3D1B1" modified="2019-07-31" version="1" fragment="single">MPSFTRPEDFEVQGGLGRCTVCNPPGHGQWIKLGNLRIHEEQRVHKQNVERKLRRQREAQATAPRRMVAPPVLPTDEPLGPQPEFDLDCEYSTLTELSRDHMDVAPLQDSEGVKRMQRISLAMENALAGRVFFSAGEGPLLGGGDSEVTLEEVLAGAGLLRAIMHPEEEQEEEVWVHDGHEASQDDPGAYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5K9</accession>
    <name>A0A4Q9Q5K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_810841</name>
        <name evidence="2" type="ORF">BD311DRAFT_777278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU62575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5K9"/>
    <dbReference type="OMA" id="FKFRTKP"/>
    <dbReference type="OrthoDB" id="2555959at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9216" checksum="CB9466EBDEC8841C" modified="2019-07-31" version="1">MSQTPKTPPKPAPKQPEFKFRTKPVAERSIWESWAVLPAKTRLRISLAITTVAAIGIWASDKLEEAIPAPKDAAKTPQSPSPNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q620</accession>
    <name>A0A4Q9Q620_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q620"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23177" checksum="0A81208C9D60DBCC" modified="2019-07-31" version="1">MLSGYSVLIQGMRPAAGTICSRCPRLPIKLPMNSLSPAHPSPPHRSSDLFSPPQTSSKMLSTFYSWSIEHIKRVFEAKSERDCLQALDETFSQRLEFTFNGSPLPRVGLQKIVLAMLQSSGFCLNVDWLNAVEVPRDGSNRNGMLGGYYVIRNVRKPLPGSSTLALFERHKSVNVEIESESSDPSFDSRRIVKLAIVATDVPVPSSHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6N0</accession>
    <name>A0A4Q9Q6N0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_918210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6N0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5869" checksum="EE86D6A635957A71" modified="2019-07-31" version="1" fragment="single">MKMTRAYKPTTEPQSIAVVPPKEQGPASTNPKSFDDGCLDRHTPTIPSWPSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7Z1</accession>
    <name>A0A4Q9Q7Z1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_771061</name>
        <name evidence="1" type="ORF">BD311DRAFT_616846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143548">
        <property type="protein sequence ID" value="TBU22304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7Z1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU22304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10456" checksum="141D2AB558D267F0" modified="2019-07-31" version="1" fragment="single">TLRSFALTCRKLLSRTRSRLFSVICLKTQGHYLCLCDLSDNTPALCPLIYTVTIGTKAIWDADGEMCGTARTALLLHEIVPAALLAQLPNLRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q835</accession>
    <name>A0A4Q9Q835_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_808584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q835"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="39782" checksum="8D78631449032761" modified="2019-07-31" version="1" fragment="single">GGELKDRTGTPLFIARSVSLGLVLIDSESLFGAPMPKLTGDALHLYTTAYGQERYDRYNDDPVARTCHGGFPPTNNSHPRAIKEAPKPDFIHRPEHDVESVYWTMVYALLRVQPAGAPVERDPSTASAIVWNTLLSHHIPGEKRVRSQEKRHEITGMAKQEWLDLFHATMEDVALLLWQVTQHVTSEYALWKWEGNFQPDHLHEAVQRLILQYLVDHREKDIKLDPRRRRPTTPRSAHQGDTPTPTQLSRLQATGVTGNHTRGQVGSGRGSAASRNRGRGKGSRYAANRKGSAQNNTAAGGPSQQSVHSREQAMTNEPVGNSKRKSSSKPSRSSKRLKTLSGEPVPPAGQDDDDDVNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8W6</accession>
    <name>A0A4Q9Q8W6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_915040</name>
        <name evidence="13" type="ORF">BD311DRAFT_713755</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8W6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8W6"/>
    <dbReference type="OMA" id="TCAHKAN"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="12">
        <location>
            <begin position="42"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU32805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU63929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="373" mass="40731" checksum="2A1F342BEE4E51E0" modified="2019-07-31" version="1">MIRNALASAARPVLNARTATTLSAGFPKVTQRLPTKYGGVYTVTLIPGDGIGNEITDSVKEIFEYVNAPIEWEQYNVSGMSSEGEDLFKQAMESLRRNRVGLKGILFTPISQSGHISWNVAMRQQLDIYASVVLCKSLPGFPTRHDNVDFAIIRENTEGEYSGLEHQSYPGVVESLKVSTRAKAERIIRFAFDFALKNNRKKVTCVHKANIMKLGDGLFLNTFRRVAEEYKTTGLQFNDMIVDNTSMQLVARPTQFDVMVMPNLYGAIVSNIGAALVGGPGIVPGCNVGREYALFEPGCRHVAKDIMGTNRANPAAMILSSTMMLRHLGLDHLANTIASATFDVINAGKVRTADMGGSATTSEFTAAVIKNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAQ0</accession>
    <name>A0A4Q9QAQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_943683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13043" checksum="9959686AE557ABF1" modified="2019-07-31" version="1">MSRVALGARRPGTDAYGVPVEVFHRDTMHEAIEIRLPDEAPTVCAHSLTGIRRVTGRLSCGISTRYCRNTDSSYTASTFLTPVVVPFDLHLTFRHHLPTLDTNVSHVAFQVVGVVQGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB86</accession>
    <name>A0A4Q9QB86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1001854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB86"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB86"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14728">
        <property type="entry name" value="Ere-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1660.10">
        <property type="entry name" value="EreA-like (biosynthetic domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1870.10">
        <property type="entry name" value="EreA-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007815">
        <property type="entry name" value="Emycin_Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052036">
        <property type="entry name" value="Hydrolase/PRTase-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014622">
        <property type="entry name" value="UCP036794_erythomycin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31299:SF0">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05139">
        <property type="entry name" value="Erythro_esteras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036794">
        <property type="entry name" value="UCP_erythr_ester"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159501">
        <property type="entry name" value="EreA/ChaN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="55625" checksum="D54AF5747CF72819" modified="2019-07-31" version="1">MPAESIREKEVLRAHIHPLSFSSSSYDPLLHAIGDAQIVLIGDGSHGTYEFYAHRANITKRLIEEKGFTAVAVEADWPDAFRINRYIHGGDTRTGKIKNARDSLAEFERFPKWMWKNEAMPPFIEWMKQHNQKVAETEGDASGTVSFYGMDVYSLHRSAEQVIRYLETVDPEGAKQARKKYNCFERFGEDTRRYAYETQFGLKKDCHREVIDNLKNLLLNRQRFIEQEILRDKFAHPHEEQFVAEMNALVVKDAEEYYRTMMTEDVRSWNLRDEHFARTVSGIAQYLGLSPSPRGGAKVVVWAHNSHVGDARATDMGKRRRESNVGQRCREIFSNDKVFNIGFLTNRGTVTAAHDWDDPPYLQRMNPPIDGSIEDVFDKWADQDCFVVTHNIVIDEKGATKKVEVNEGLSDFLNRPRYQRFIGVIYRRLTEILSHYSKCSVRQQYDAVAHIRESRGIQALEPEETWKGPKAEMDMTFPFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC82</accession>
    <name>A0A4Q9QC82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_291803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC82"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC82"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020397688" evidence="3">
        <location>
            <begin position="32"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="247"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="524" mass="52522" checksum="D8016A262294AA18" modified="2019-07-31" version="1">MFRLFVVYDVFLVQLVLAFLFLLSFTDAASGAPANATIRFDSPLISFSAGWSLAEFEGAGTEDQFAFANKDGEQLVVQLPRNVSAVFYQGFKSNGGALWFACLDCDPSQDAGGNVLEVDAHDDTENGTQPPEILFSFTNVDPTQLHVLTVVNLEDARFNNTSQITFDALILTIDGVDGGQSPSTTTTSSTSVTGGSIPTITVTAHGPHSTVAAPTSTGTTDTSSTGTSSGSQAATTTTDGSNGGGAPTTSTGATSSDQGTQPTGTGATSSGQGTQPTSSPSGVTTTSSDGSQGSSTSDSNSPSGSQTQTQNPTSTGASGTSPTGTGSQTGTGTSGSPTGSESPQPTAGPDTGSSGTGASGTGSSGRATSTSSGAPGNGSSNNSSSTNPGVSKTVIIVVAVIASLFVLALLAAITWLLVRNHQPPPSTDPEGSAGLMREAAPVSIVSGPVGLAPMRPVNPFVDTVPSNMPLDDGPFGDPASESPPRIGLPPIPPRSPLRATYSSSPTRPAWLTRTPRTPSPTSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCF9</accession>
    <name>A0A4Q9QCF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Elongator complex protein 3</fullName>
            <ecNumber evidence="15">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_1033763</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="15 16">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ELP3 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="15"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCF9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCF9"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000003">
        <property type="entry name" value="Elongator complex protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056591">
        <property type="entry name" value="ELP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01211">
        <property type="entry name" value="ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23613">
        <property type="entry name" value="ELP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005669">
        <property type="entry name" value="Hist_AcTrfase_ELP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13 15" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15 16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 15" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 15 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 15" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 15" id="KW-0820">tRNA-binding</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR005669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005669-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU65427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="554" mass="62627" checksum="EBC29B702F4D9C69" modified="2019-07-31" version="1">MVQRTRTEGPSQAETLLRVTSGIAAELIKAHDANQTVSLNELRAKMSKKYGFGGVPRLVDIISAIPDDYKKALLPKLRARPIRTASGIAVVAVMCKPHRCPHIAMTGNICVYCPGGPDSDFDYSTQSYTGYEPTSMRAIRARYDPYEQTRGRVEQLKSLGHNVDKVEFIIMGGTFMSMPEDYRNAFIAQLHNALSGFTGLDVDEAVRYSELSKTKAIGITIETRPDYCLRPHLSQMLRYGCTRLEIGVQSVYEDVARDTNRGHTVRAVTESFHLAKDAGFKVVAHMMPDLPNVGVERDLEQFKEYFENPAFRSDGLKIYPTLVIRGTGLYELWRTGRYKNYTPNVLVDVVARILALVPPWTRVYRVQRDIPLPLVTSGCENSGNLRELALNRMKDFGAECRDVRFREVGIHEIHHKVRPESVELLRRDYTANGGWETFLSYEDPERDILIGLLRLRKCSDEGTFRPELVRQEEGGCSIVRELHVYGTAVPVHGRDPTKFQHQGFGTLLMEEAERIAREEHGSVKLAVISGVGTRDYYRRLGYELDGPYMSKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCS4</accession>
    <name>A0A4Q9QCS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_805163</name>
        <name evidence="9" type="ORF">BD311DRAFT_648520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCS4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCS4"/>
    <dbReference type="OMA" id="WLRLMCC"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="116"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="8">
        <location>
            <begin position="211"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="7">
        <location>
            <begin position="215"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU35154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="440" mass="50761" checksum="461C2B7F5127225B" modified="2019-07-31" version="1">MKDVSNATRASRPSAYPKKKPSPYGVSKSSRRQSPLYPPHSLVRKTPRAAKAELIAQRQRHLQISALRREGIYLEEEYHEEIRAYMHEMERLTMCSISSMDQQPEIRWHMRPCLVDFLVELHFMFRLRPETLYLTLNIIDRYVSKRVVYVKHYQLVGCAALWIAAKFEDAKERVPTVHDLAQMCQETYDESAFIQMEGHVLSTIQWALGHPTAESWLRIFCCGPIMEEQKVQHVARFLMEITLFYREFVQYPSSAIAFGALTLARYLCGKGRRLFEETEECLEIVDHLDNRLAKHANELSETLVKKYSYAFYSKAATFTLQFYLQGGRFQRQPLVTLPMTPVRTYSSKVCTPMSVSTTASDFSDDMPATPTSPILSSDAFSGSYMSDDKENLPSPKFEPVLNKQLIEQVPEQFLPHDFVTYQRQALHNLNVSSPRPAMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD38</accession>
    <name>A0A4Q9QD38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_943146</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD38"/>
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    <sequence length="452" mass="50194" checksum="FC59461F96803A5B" modified="2019-07-31" version="1">MSVAVPAGFRALPLSLAQLSLAAVLKCGQSFRWSILSLNVPSNSALEYNLPTHEYRLCLRDRVVCLRQSPDTLFYRSVFPPLVSGDEETREAETLGWIRDYFQLNIDLVELYRQWSLADPIFKRIQDRFEGIRMLRQDPFENLISFICSSNNNISRITKMVTSLCRTYSPALLSLPPPAGTDLTEEAYHPFPSPSTLAAPEVTAKLRALGFGYRADFIQKTAAMLVETHGLTRNPKTSMEASEEWLMTLRHLDTPEARAELLKFMGVGRKVADCILLMSLDKREVIPVDTHVQQIAIKHYGFRGPTKSGTMSPKVYEELSCKLATVWGDYAGWAHSVLFTSDLKSFASYGLASPSGISISTPSTPGLTPDRSTYEPVDSPGVATPRSTSTPQSKKRKRGGPKRSGSKTPSSEMEETLAQLEVGVKVALPDESGQSTLIDRVKRRRRGTVSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDR1</accession>
    <name>A0A4Q9QDR1_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_5388</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
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        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU65366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9630" checksum="F636C65EAC476F31" modified="2019-07-31" version="1">MAPHEELRPWSRNSSARSSPRIPRPQKVQRWVIYFLLFLQFDRAAGSKSRWSRSPNHVRKQYQLTKGKKMFLLPQTHARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEP0</accession>
    <name>A0A4Q9QEP0_9APHY</name>
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        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">BD310DRAFT_912963</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Sda1"/>
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    </dbReference>
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        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
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        <property type="entry name" value="SDA1_N"/>
    </dbReference>
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        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
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    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="60"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="195"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="551"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="724"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="537"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="537"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="590"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
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        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU66205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="772" mass="86241" checksum="D75C2EC7C50B6759" modified="2019-07-31" version="1">MGRGVLLTSNLPQLQNLIKRDPSAYKEEFLQQWNHFNSIRQIFQINPEENAQHFRELVSFVAQVAQCYPKETSDFPSQMSTLLLENYGTLSPDTRKSLVQNLVMLRNKNVITSITLLQTLFPLLPRTTSSSLRSFIRRTILSDIRTANLRVKNHKLNRAVQAMLFGMVERGMDAEVVGDKGKLRAAARPSAAGSNGEEAMWAVVLTKELWRKGIWNDAKTVSIIALGCFHPVVKVQSASLHFFLGSDEEKEDSDEEEEDLPDVKSLQHRREINKKTRSGAKKLEKQIKTIKSKQKKKTDSSNPNFPAIQLLNDPQTFGEKLYDLLNKYDKRFSLDHKILIMQLLSRVMGGHKLCVLGFYTYIMKYLTYHQLRIPAILVALAQSVHEYTPPDALTPVVRKLAQEFVHPGVGSEVIAAGINSIREVCRRQPWAMEEDLLGDLIEYRKSRDKAVTAAARGLLQLFREVNPGMLKRRERGKDASMGMAKGSQPLPFGHSAEAAVDIEGLVLLEDHLKKLREEDGAASGDEDEGDEAAWEGWDVESDSSEESSDGWLDVDSDSDEDIEVSDSEDEDGNKSKKSREKGKGKAKAGDDDEDAEMDDEDEGKEDAAEDAVKRISTLATTKILTPADFAMLNDLRIKAASEAVERGGGSSAKRKLATLESQKKSLLASDGNLADAFISENDILGPRKKAKADYAERIASIEKGREGREKYGSLKGKKNKERPSSSTNREKARNKPIMMILASGAVKGKKKASLRQKQQKLRAHIERAKKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QF81</accession>
    <name>A0A4Q9QF81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_902282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QF81"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16439" checksum="2767319A26A9E79A" modified="2019-07-31" version="1">MGLGSAQAHMHIAEFRSSTRRVQPRSCTPEARTSQVAEAAAWDAKIRVQVSDAQSELRPHTTADSASETIAARGAMLQGSEPDTHIPWITARRSYSSIAQGSTGHGQLVPMATDRGSARAEGGSLQAQHEYMIVTYPKHDVLDEWAACSPKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QG04</accession>
    <name>A0A4Q9QG04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NUDIX hydrolase domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_804581</name>
        <name evidence="4" type="ORF">BD311DRAFT_662362</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143417">
        <property type="protein sequence ID" value="TBU28960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QG04"/>
    <dbReference type="STRING" id="114155.A0A4Q9QG04"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047631">
        <property type="term" value="F:ADP-ribose diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18888">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF1">
        <property type="entry name" value="ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU28960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU66201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="207" mass="22715" checksum="39E3B7BA2BDE8020" modified="2019-07-31" version="1">MSESKVLSVEDLQTSEAKWVKLKKCTWRDPDGKERPWEFATRPTRGSGGVDAVAILAILRSESNAFPPSTIIIEQFRPPVERYVVELPAGLIDEGESAEGAAIRELEEETGFKASSVIQTSPLLVCDPGMTNANMKLVTVDVPFPEKLEMPAQKLEPGEYITARIVELSKLAAEFKGLSSIGFVVDARLSHMASGFELAERLRQAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QG22</accession>
    <name>A0A4Q9QG22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_912220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QG22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17430" checksum="DE0037C6745FB5E6" modified="2019-07-31" version="1">MSPVFRQSGESIVWQRTLEARRSCLPSSLCSLICLLESSRLPTPVPPCSRADPRCHPSSARSHRCRLRRLILSQQTCRNMSHLHRTATGPCIPTISGSGVAGFAGAHRGQTGLCAGLPIVVAAGPCGCAGELRLDARTSVRDAATRCFHVPLCYLSCHSNAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K2Y3</accession>
    <name>A0A4V2K2Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_922942</name>
        <name evidence="5" type="ORF">BD311DRAFT_669290</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143458">
        <property type="protein sequence ID" value="TBU25589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K2Y3"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF4">
        <property type="entry name" value="SPORULATION PROTEIN RMD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="293"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU25589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU60421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="559" mass="61798" checksum="744218271EB21C3E" modified="2019-07-31" version="1">MSNPPPAPRAPSLPPSTSFRARPSRTPTSGTRTLTRRPSVSGVALTNPVTGTSKTQRTSKTTQKLVVLPSAPQTKPPPPEADTDEEQLHGYETDRGVREHKSAGERMSKEQREKAGFRRITAYCLAEGFRMKLLASFLKREHNVRPRIYDEAMYVIYHLPLLPGYTTGSNIRSSAPASSPGAEDPSSGLSEVEEDGYQGTYFTSIEPSTTPPMEGFMPSASPETATHITPVPPQEVVSEQLRVSETEPILLSAEDIRPAMSMPTRDGPGSTRSRAARRRRTTAEEPQNFAEAVFFEYGVVVFFGFREDQELGILEDVEAASVMLRKIPRDDWEVEECHYAHDPNIAFPRIYNDFFTFKTHSHLLQLSVAHALAQSTLLARYESLAARILASPQTRSIPAQLASTGVLALKRKDALKLTGKLFKLRRDVNLVSNVLDVPELFWDEASLKALYDAVREYMEIGPRVQVLNERIAVAEDLLGAIHDHLNNNAMDRITWIIIWLIVVACLVEVGEVIARLVVHATMGDSEPAAALTAAQVLNSMSREDAIAALERIARGLPPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K730</accession>
    <name>A0A4V2K730_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MCM C-terminal AAA(+) ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_935769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K730"/>
    <dbReference type="STRING" id="114155.A0A4V2K730"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6678" checksum="9D7DC76A8B0AB8F9" modified="2019-07-31" version="1">MQCQQHDFYLEEGAMVFVDTGVDCVNELDMIRGEDRSAIHETTHGAAGPLTVFIPFPGSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7V2</accession>
    <name>A0A4V2K7V2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_549119</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5"/>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7V2"/>
    <dbReference type="STRING" id="114155.A0A4V2K7V2"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000006">
        <property type="entry name" value="Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004309">
        <property type="entry name" value="PRK05704.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="121"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU57528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="49134" checksum="B2F2433AAF2ACDD3" modified="2019-07-31" version="1">MFSRRLVHLARGRALHADAALLSRGWKVAGAYAQRASFHSTNLLQAETVKVPQMAESISEGTLKSWLKQVGDTVQADEEVATIETDKIDVSVNAPAAGKITELLANEEDTVSVGQDLFRFEPGAADEVAPKEQKSSEEGKDLKETKDKSEPADQQVEKGTPPPPSPSPEQVRKPDPAGVQEGTAKKELKDTTKPAPAPAPAPKEKGEKKDAPAPAPRVPGSRNETRVKMSRMRLRIAERLKESQNAAASLTTFNEIDMSNVMEMRKKYKDEVMKEHGVKLGFMSAFAKASTLALKEIPAANASIEGDEIVYRDYVDLSVAVATPKGLVTPVVRNAEGLNFVEIEQEIANLGKKARDGKLTLEDMAGGTFTISNGGVFGSLYGTPIINLPQAAVLGMHAIKDRPVVVDGQIVIRPIMVVALTYDHRLLDGREAVTFLVKVKEYIEDPRKMLLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K824</accession>
    <name>A0A4V2K824_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_948723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K824"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19271" checksum="3F45AD602B74A972" modified="2019-07-31" version="1">MSDLHSFVAFLKNHGSSVPRSPSIRVLQLDELKAIVAWLSGRNAYSEAFSASGSAPTGRAPRERMMPNAYPTTPCPETQEEPEEAWERTVEGSGAPEETLVLTVEEMKFAVWEALTCYILVLFILYGLWRFVLPPALTLFWAAFRTVLSVIDRALDIVDRAIWPIALLTFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8I4</accession>
    <name>A0A4V2K8I4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_905523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8I4"/>
    <dbReference type="STRING" id="114155.A0A4V2K8I4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043355098" evidence="2">
        <location>
            <begin position="19"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="34788" checksum="BD8B0843AF3089A1" modified="2019-07-31" version="1">MFRLAPLASLALASAVFAQSYTATYTPDDAPDKSEQGQAGTNKCGTGNDQNSMCQNVYVNSLDDFCLFAPPNPGASSTIGDTERIEVSWCVQGGHGTRVIPDGTITGAHFVQTPDYVQVTGVGDFTKINIPQGDEGGELDPHGADGNGNPIGGLVFSNAFGSVTQMHEWTNFMAYNEFCIRACKGPNAAALCQHIYDVMGCDWNMPGDYSAGSFDSCHGDSGEPMGVYGTSTFHQGQPSTPDAHPAPPKSQCQQANTIANGVTISTPPVSASTTSAPASTSAAASTTSSGSVPSTTSGAASQTGSSTSTGSATGTKSTGTSRTSAPPHARASVAKPNETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWP8</accession>
    <name>A0A4V6MWP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Multifunctional tryptophan biosynthesis protein</fullName>
            <ecNumber evidence="5">4.1.1.48</ecNumber>
            <ecNumber evidence="4">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_691378</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="5"/>
    <dbReference type="EC" id="4.1.3.27" evidence="4"/>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWP8"/>
    <dbReference type="STRING" id="114155.A0A4V6MWP8"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0822">Tryptophan biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU55298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="290" mass="31442" checksum="D0A11984E363A22D" modified="2019-07-31" version="1">MSANGDATKPPTILEKIYAQRQQDVEAAEATPGTRPEEIDAYLQMGLAPPLIPLVPRLRTNPSTATASPSLSLMAEIKRASPSKGDIAPHVNPARQALLYAQAGASVISVLTEPTWFKGSLLDMRLVRQAIDALGPARPAVLRKEFIFCEYQIAEARLHGADTVLLIVAMLTQEQLARLYAYSLSLGMEPLVEVNNAREMTRALEVGAKVVGVNNRNLHDFSVDMGTTSGLVDMVRERDVVLCALSGIQGPEDVRLYKEQGVNAVLVGESLMRAKDTTAFIRELLAWPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M3H7</accession>
    <name>A0A4Q9M3H7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantoate--beta-alanine ligase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pantoate-activating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Pantothenate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_982508</name>
        <name evidence="7" type="ORF">BD310DRAFT_982920</name>
        <name evidence="6" type="ORF">BD311DRAFT_802930</name>
        <name evidence="5" type="ORF">BD311DRAFT_812421</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 9">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143627">
        <property type="protein sequence ID" value="TBU21305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145393">
        <property type="protein sequence ID" value="TBU51118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145308">
        <property type="protein sequence ID" value="TBU51558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M3H7"/>
    <dbReference type="OrthoDB" id="2020436at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU21305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU33949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU51558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11006" checksum="927D8C8DB1BA92C1" modified="2019-07-31" version="1">MAHSPDLRFTRPAPPGLLSPRTSTLLPQHDYRTATIAHPTLPDSHVVKGLEEEGIDEKKSIGFVATMGALHEGHLSLGCASAVFVLTVSEMYPSGITQSVAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M928</accession>
    <name>A0A4Q9M928_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_807602</name>
        <name evidence="7" type="ORF">BD311DRAFT_768362</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="ML143503">
        <property type="protein sequence ID" value="TBU23509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M928"/>
    <dbReference type="STRING" id="114155.A0A4Q9M928"/>
    <dbReference type="OMA" id="CAYLMWK"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="63"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU23509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19850" checksum="1AB3FB5A573EAF55" modified="2019-07-31" version="1">MVWKNINAVIEGKLYLGTIDAAISPRTLADRRITHIVSVGSEPIPADNPASGIRHLRIRVEDVDYADLLIHLPSACRFIHDGINSGGVVLVHCVQGLSRSATVVAAYLMYSRRVEASEAMEIVRRAREQIWIIPGFQEQLVLFGLCQYNPTPNDGIYVRWRQKIDRYLQSQGQARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MHY2</accession>
    <name>A0A4Q9MHY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSm2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_933299</name>
        <name evidence="11" type="ORF">BD311DRAFT_446222</name>
        <name evidence="12" type="ORF">BD311DRAFT_446470</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143445">
        <property type="protein sequence ID" value="TBU26497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML143445">
        <property type="protein sequence ID" value="TBU26506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MHY2"/>
    <dbReference type="STRING" id="114155.A0A4Q9MHY2"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016394">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU26497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU26506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU55659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="11023" checksum="3E613E44092D0060" modified="2019-07-31" version="1">MLIFSVFKTLTDQRVTVELKNDLSITGTLKSVDQFLNIRLDNIKVLDEARHPHMMAVKNCFIRGSVVRYVQLPAEHVDTQLLEDATRREAAAQNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MQF2</accession>
    <name>A0A4Q9MQF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_961869</name>
        <name evidence="1" type="ORF">BD311DRAFT_788547</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143422">
        <property type="protein sequence ID" value="TBU28376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145206">
        <property type="protein sequence ID" value="TBU53750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MQF2"/>
    <dbReference type="STRING" id="114155.A0A4Q9MQF2"/>
    <dbReference type="OMA" id="EARTCLM"/>
    <dbReference type="OrthoDB" id="3036049at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27320" checksum="DF4A7BF25799580A" modified="2019-07-31" version="1">MHSPPQKRVRLLVETEDEKDCQAPRAKSLPIEGSVLRDHEFWFKDGNIVLVAEKTAFCLYIGLLSAQSPVFQNLFSATKLNAEEYIDGIPVVRVFDSPHDWRHFLRALIPKDELFDCFPSISATIRLSHKYQVDCVKSEALLALQGLYPSDFESWLEIDTEVSQEWNACGQAVNLARLTETSSILPAALYYCSTLGGAVAKGYRREDGTIAYLSQDDLVRCIHGMRALTGASSDYVRGMSRPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MSZ6</accession>
    <name>A0A4Q9MSZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PAP2 superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_831501</name>
        <name evidence="10" type="ORF">BD311DRAFT_661124</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the type 2 lipid phosphate phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143413">
        <property type="protein sequence ID" value="TBU29471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145237">
        <property type="protein sequence ID" value="TBU52786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MSZ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9MSZ6"/>
    <dbReference type="OrthoDB" id="301434at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03388">
        <property type="entry name" value="PAP2_SPPase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF28">
        <property type="entry name" value="DIHYDROSPHINGOSINE 1-PHOSPHATE PHOSPHATASE LCB3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="9">
        <location>
            <begin position="121"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU29471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU52786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="543" mass="60206" checksum="94C7E5B5C18B8B77" modified="2019-07-31" version="1">MNFRKADVDRNWNEKAENAGAAQVAGDGGEREILLAVGAAGRLPEDVYERTLSGWRAGLRRVIMRNIELESKALAIMQSYVRHPVLDAYFVYTSSLGTHTFFMIMLPLFYFFGAPDFGRGLLLMLSTGVYVASFIKDLCCVPRPYAPPVTRLTIGDHHLEYGFPSTHSTNSVSIALFLYTLLQRAYTPASTAIKSSIDSAVSSVNATSVLPTAEVVELVQGQISERTYQLGVALLLFYVFSIVYGRLYTAMHSFTDCIMGVALGAGIWGLHVLCREYVDNWVRDGGFIVPATIVPLCLYLVHRHPQPVDDCPCFEDAIAFVSVVMGEFVARWYMEHNGYDESFFARPMPGATWATWSDVVTWWSTAATKTVIGVLTIFIWRIVAKSFCHFVLPPTFRFLSHLFTLPHRRFYTPATDYTSVPPEKGLRPIPSVIDLPRMVEYEVDGVGASDAAASTARRSYSAIKNRKGGRVEMDEKVVAMNEKSAKGRPGLSVELDEETGGKDVKHYDADVLTKVFVYCGIGILAPGVIPVMFEILGWGVKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MZ06</accession>
    <name>A0A4Q9MZ06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_918163</name>
        <name evidence="1" type="ORF">BD311DRAFT_748485</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MZ06"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8844" checksum="CCE4FF935787667D" modified="2019-07-31" version="1">MRFAESELCRVTCSCTLVGRSMASEPLPHKNPATASIYLFLCSQKGVWLYCSNLIWLPESVCYTLLSRSLERRRVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N2Y9</accession>
    <name>A0A4Q9N2Y9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinate dehydrogenase assembly factor 2, mitochondrial</fullName>
            <shortName evidence="3">SDH assembly factor 2</shortName>
            <shortName evidence="3">SDHAF2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_830244</name>
        <name evidence="5" type="ORF">BD311DRAFT_650609</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with the flavoprotein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDHAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145216">
        <property type="protein sequence ID" value="TBU53363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N2Y9"/>
    <dbReference type="STRING" id="114155.A0A4Q9N2Y9"/>
    <dbReference type="OMA" id="YGKPQNP"/>
    <dbReference type="OrthoDB" id="284292at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.250:FF:000004">
        <property type="entry name" value="Succinate dehydrogenase assembly factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.250">
        <property type="entry name" value="Flavinator of succinate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03057">
        <property type="entry name" value="SDHAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005631">
        <property type="entry name" value="SDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036714">
        <property type="entry name" value="SDH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028882">
        <property type="entry name" value="SDHAF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469">
        <property type="entry name" value="PROTEIN EMI5 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12469:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03937">
        <property type="entry name" value="Sdh5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109910">
        <property type="entry name" value="YgfY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU34248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16891" checksum="8CFF8306F7F200C1" modified="2019-07-31" version="1">MSSTSATVYCQRLLSVTARRGADPWLLPNMPGHLEKTTSPPDAPAPEPLPRPGESVEKMRARLVYQSRKRGTLESDLLLSTFAQERLGSMGEEELREFDKLLDEPDWDIYYWATGKKAPPARWAGSRVLAKLAEHTKNEGKVVRRMPDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N5L5</accession>
    <name>A0A4Q9N5L5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_863981</name>
        <name evidence="18" type="ORF">BD311DRAFT_707594</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
            <strain evidence="18">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 21">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N5L5"/>
    <dbReference type="STRING" id="114155.A0A4Q9N5L5"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="236"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU35535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU65377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="402" mass="45640" checksum="E60B5FA2BE68C7DB" modified="2019-07-31" version="1">MATEGSLQDLQENEIESNWDQIVDNFDNMELKPELLRGIYAYGFERPSAIQQRAIVPVIKGHDVIAQAQSGTGKTATFSISILQKLDPAIKGTQALILAPTRELAQQIQKVVIALGDYMNIECHACVGGTNVREDMAKLQEGVQIVVGTPGRVFDMINRRALRTDNIKIFCLDEADEMLSRGFKDQIYEVFQLLPQDTQVVLLSATMPADVLEVTKKFMRDPVRILVKRDELTLEGIKQFYIAVEKEEWKLDTLCDLYETVTITQAVIFCNTRRKVDWLTEKMHSREFTVSAMHGDMDQKQRELLMKEFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTTEDVRMLRDIELGLTATSLEFYNTQIDEMPLNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N848</accession>
    <name>A0A4Q9N848_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N848"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="12"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="9164" checksum="9600878E4FE15403" modified="2019-07-31" version="1">MLPLHNAAVPIHTLPTEVLVKTFGRIWQCRRSLHLTSVCRRWHMICLSSFSISEIERHPRFRGRFDSSGDHGQLGVRDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAZ9</accession>
    <name>A0A4Q9NAZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_847696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAZ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="531" mass="59560" checksum="221CA66CBEED5314" modified="2019-07-31" version="1">MVGLHQDILEAITEFLDTYPDLLAVSLTCSALRPKAVQCLLSLRPVTLTNERIVRAFHDFIYIDPEVRGRHIRGLVTPLRYSRRGLIPHDSNADIATIFIAIIKSATRLKHLTLSLSDLYPSYLDDSRVVPVVGGLSTLEDLAVLGDSQRGHELLRIMQSPVRTIRIRNINYDPASPVYLDSMSNLAATLESLELGLGQIYIHEFETRPRFPSVHSLTIAIVRGPPRLDALLHMFPSLSGSLFLFHPSPIAFNEDTIRQSNKRAQESSSNSWKRIDHVSCPPKLLFALNISCSIRRITLDCWDDLEFDVYISEILRATPPQFLELTNLRLVPPVLDVLSSGLFPTEVRTTMTHLLLTMRCDGVSLDELGLRDIPAPLQWDSLVDIICSVIKSLQHLAYLRVIIECFVQPNHFDAAYTAEFVTVVRHREGSHWRRAAEVLVAAVPSLRTIVFTSNGLILNAGYWRLASGWTQCAASGDTSAEDGVGDDLGRHWRVEELGSEEMKSFVKREGLSNARDETLELWDLVADELVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIW6</accession>
    <name>A0A4Q9NIW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_592524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIW6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7304" checksum="06C3663DD7882109" modified="2019-07-31" version="1">MTTTRLWTLHRYGQDSVVTIGDAFSQHYVVSCVCLVSHGHSTSLAAQARALCTRTLPYIPIYRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJM6</accession>
    <name>A0A4Q9NJM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_825753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJM6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7030" checksum="AC898D02FADC0F5F" modified="2019-07-31" version="1">MLLVSPLRPHFSRSRYRGLQPARPADDTNTPVSSPRPPMLTDNPALVRRVLLTVDATLPPRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMK6</accession>
    <name>A0A4Q9NMK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EKC/KEOPS complex subunit BUD32</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21 22">Atypical Serine/threonine protein kinase BUD32</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">EKC/KEOPS complex subunit bud32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BD310DRAFT_938431</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMK6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NMK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000323">
        <property type="entry name" value="TP53-regulating kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0010">Activator</keyword>
    <keyword evidence="17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 25" id="KW-0418">Kinase</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="18" id="KW-0779">Telomere</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00030980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00033194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="TBU53273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="272" mass="29970" checksum="595CE1E38256F754" modified="2019-07-31" version="1">MATQDVSPTLKLLEKSEKISQGAEAKIYRAQLHPTPFTSESNSDGENVLLKYRFHKQYRHPTLDASLTKSRVAGEARAIIKCLRSGVNVPGIRMVDAAEGVLGIEWIEGKSVRFLLGGGAEDEGDIVEDADAAKDEDEVTEVKEEDLLKEYGVSADVVMEMIGTELAKMHQADIVHGDLTTSNMMLRHPASPKGLQLVLIDFGLAYISTLIEDKAVDIYVLERAFSSTHPASEGLFAGVLKAYEKKMGKDWAAILRRLEDVRLRGRKRSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQM0</accession>
    <name>A0A4Q9NQM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_350327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16977" checksum="F4E0161C0DF41663" modified="2019-07-31" version="1">MEVLWGGTFLMAIVLWLALSETDAWACDSDVVSWMFMASFAGESLEIGPRFAHYDWHIRTTYPLRSPRSDSTSRLSTSPTPRGRQLSRCVRVRARQIGTMTSSASHVRSSVIVDFLKCVRYTVRTYAYLQCTVSSFSRPDPDSVRRTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWC1</accession>
    <name>A0A4Q9NWC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_815312</name>
        <name evidence="2" type="ORF">BD311DRAFT_780206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143458">
        <property type="protein sequence ID" value="TBU25611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWC1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="380" mass="41834" checksum="ECF894BF1F39E43F" modified="2019-07-31" version="1">MEVHTGKLQMQRSWFNSFVDSELENDGHAKGWTLPTVAELWTRTKVQVLKEEEDVEEFRRLDEDVEEPDDKTPSTPGTASKTLAPLLWNALLSPRLRKGQTSQHGIDDPPPDDPYGSAGERSLELDDGDGSREIEADGAATPTAHVHRSLSLPNLSQENTELMSSPSAAYLQRKRLGAGIRREDVQLAAPSSGSTSLAPIVPASTSDVGAPDSSSVRARDNSARLGGMRRRWPPPVGPLYPKELPNGKRLPHDWATMTTSDQILMLCLSTPQDSQGNRMFKEAFQNIGLPSTQLREMLGYVQDLKSANQEKSRQTSTTPGILLPRRSVARPSAAEQLAGVLRDKNLQQAKDRHLNIGSRESRTVGHKEDVSEKGKERARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZ56</accession>
    <name>A0A4Q9NZ56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_906850</name>
        <name evidence="3" type="ORF">BD311DRAFT_659143</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143406">
        <property type="protein sequence ID" value="TBU30372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZ56"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597622" evidence="1">
        <location>
            <begin position="22"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="66"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU30372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="343" mass="37342" checksum="E0C70134DCA5B569" modified="2019-07-31" version="1">MLSFEPLLGLLSLLLTLGVQGVATMRVSTYNLRYDSMPNNITVAQTLSALPDPLTPPTYYGAKGEQPWSTRRVKVYEHLNNAGVVLAGFQEALVRQVDDLATLFGDEWSWVGVGRDDGVAAGEFSPIFYKKSDIELISNDSFWLSNTPFEPSKYPNAGSFRICTATHLLLKTGPSGPVRFTYLNTHLDDQSDDERRLAASLMLVRARYEAYTTNGPVIITGDFNSPSTGTDSGAYQIITGQIPPEPVNATFAAKYAVPNGTLSDFTMLDLKAEVPREYVSGEYATYTGFGAPGDATDFTRIDFVYGGSNGKWTATGYHVGTSLTDDGVLASDHRPVFADITLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZB5</accession>
    <name>A0A4Q9NZB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TRP C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_621422</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZB5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZB5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="202"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="525"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="608"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="TRP C-terminal" evidence="3">
        <location>
            <begin position="240"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="932"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="939"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="985"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1024" mass="109259" checksum="7E419E2C854C067A" modified="2019-07-31" version="1">MAGLRKPDLLRRGLFRVLLLCASLVSYFMITTAQPATVQFSDCFSSPNISQKLDVSTVYAQYFPKSSNGPYINFTVIGTSPQQIVSASNGTNPVATTLFTTTEVLTFPQPNNHGNSFFCATLRPASPLPEADPSGSFCPLDPGPFAFSSSVQVQPGSALLTLDTRLRALDPFQTELLCLDVNTTILDPSSGGPDSVYGHANIIFWSTVGLAIGYWVVVGIARLVAAWGRGSSRGGNGFLARVEGAGFVLASALSGERFASSPALMRFCTPSLRDIVFHTQWCAVLSMVAVQWPMFTYPLLSQTAWATLSYNISLTQGKNADHLRWNPLTVQPYNPPSIFADQLNDPSSPIFIDSSAPNFLFQLPPNATTGMSAFAWSVGLRPQDLFGICVSIFLAIVAATIVLSVLVWALDFFMSLIAGAAGGGAPTPTGLGGTRSPRYSSASKDMLDGIGMSTTDENRSLNGHFLFSRSTSRFPNTRAWWRWRSNFVSFHGSALHGNLVRLLVLFHLPITVFSCYHMSLPRSQASVGSVVLAALSFVFLSVLIPAFLVFRLTTTRTSKLYDETWTLLSLGPLYNHYRHGSQLFACTLFAINIAFGVTIGFGQKSGTAQAIVILVVEVASALGTSVWLPWGQGASMGLISFLFCVGRIVIAVLLVILTPVVSIGAGAAQWVAYAILFILGLIYLAFLLMLIVKIVEAILRIAGGIGFGRSRHVVDSGLLGTLGLMGCCGPRHPHRNGGYRPAVDRPPSTLALPRPMPLYKNSTPPSSGPPSVLRPEHAMQPYKEDSDDETGFIMGAWQPFPGPGMSQVEEQAPPEPPKSGFARVAGGRAHYDSPYAIASGSTTTFPSERNRGPGSFAKSTPSVVQDSPPPTPSIASAARGLPPGAMPPAHVRTKSQTAIIESAPFMAAQAATVAGGSGGALSGHQADAVAALAAEPQPKKKYWYSRKKNRRMSESDAPLSDPVPVSQESGRSFVVMRKPRPGMPSPSQGSSASQPLEGADEQGRRSFSVLRGTSHSDLQTPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1D6</accession>
    <name>A0A4Q9P1D6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_3326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1D6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18526" checksum="6D2D30E7B9FED510" modified="2019-07-31" version="1">MDSASSTHSPCGPVTPSVGTVSHACLHARLAPCPDASRCVKPRIPFSRFICALSRGYGRNRGPWTLDGSAAFPSQLQLSTDTGIPRRARFTVALFRSQACLPEVLAQHARVCNYGRAILSPVPGSKRARAIYTGEGPVYDRLWRGTLLPYSMHPNIHTDSYSMEHANFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1R0</accession>
    <name>A0A4Q9P1R0_9APHY</name>
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        <submittedName>
            <fullName evidence="7">RNA splicing factor PRP9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_927250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="term" value="C:spliceosomal complex"/>
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    <dbReference type="GO" id="GO:0003723">
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
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    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="287"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
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            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU58406.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="528" mass="60601" checksum="A7CDE41EB75667EC" modified="2019-07-31" version="1">MDSVIEVQRQTHEEIEHLERALYATLSKTQSTHQVRLQNEHKASQLLDRIHARVVALNNLYEDQDTRKAEIDSLSAPPRQDDLSAFYDRLSKIQEHHAKYPDSVVGGFELELAAFVDEAEELDGEEFEQDDPIALLFSGEEGYGKYLDLYANHTTYNNLKHIGKRLAYLQYLDVLLAAQSSTVHTELPKECRLHRDYELYIRALHAYLLSFMKRSQPLIDIESQQREAEQQFNQAWEELGLAEEWEDSKQAKAATGENGESIGIWCTACQKMYSKQTVYDAHLNSKKHIKAAQKQSESDAPPPNPNGPTPTNGAHSVNSNGDSSKASDKNKHRTAALFTHLVSQLLRELASALNDTKSNVERRFSLTAREREQELLEQAKKPPPPTKMPANGEGAEEEEEEERIYNPLKLPLGWDGKPIPYWLYKLHGLGVEYRCEICSDHVYMGRKNFDRHFQESRHAFGMRALGLPNTKHFHEITRIEDALALAEKLKREGRTEIFEQETMEELEDEEGNVYNRKTYEDLKKQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P240</accession>
    <name>A0A4Q9P240_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_877041</name>
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    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P240"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="TBU59371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="216" mass="24429" checksum="5A1DFEA5BE3432F6" modified="2019-07-31" version="1">MRFDEGTSHREIKRQYLKRAADRAYDLVVTKLIESSFYYVLIGRFITSGLPSLLEGAYRSFVSPECQSQIDELSGDNMQHVGPSKDDIALLVRYPEYPIHVQCSQVWERSEKRGYGLRDNSTSSTNVAMWGAEMMKRQKAYKSGSSARRERDISDAMHGRRVNIISKGKIEAIDELLRAVSTVGGVERLTWTLAKLARLMSSSQVSNRPRNVCGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2Q9</accession>
    <name>A0A4Q9P2Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1003123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2Q9"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
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            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="273" mass="30178" checksum="676EA8F7EE210757" modified="2019-07-31" version="1">MSYSYRKSNVAGGSWSTPFNTPFFIRYGESSIKVPMVKLLLEYEIWEKLRGPSNSDQGPRAPSEASFADDPFASSGPIDWAEEVEQELFFDDGASDSKDSEPVAEEFDDSDDDEVLMIVPIEDLRFSGRGLAYALYTILEVDEVVDDKCEAQETESDDADDTDSTSTISTDSAYSTDSTTSTDSTTSTDFDLSAFRLDNINTADSGSSVDTVRVEDPGSVSGNLFHGAIQHLSVMALLKLDAYIRFFQIAAQISLNRFPFWLNSPFNRDRGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6X2</accession>
    <name>A0A4Q9P6X2_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6X2"/>
    <dbReference type="OMA" id="YAHCNSQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17905" checksum="DB293DEE46FC0720" modified="2019-07-31" version="1">MQPSTIKPQRIQHTRAPSLSFSYFPFPSDRQFPLYAHCNSQRTGCVPTIRCDTNLVVSSHRRDLMQTVDYRFSPKCTRRSSFALSDIFEMDEEVVEFEISPILPSTPNSATTRSVKLRMKTALHDFVQAVKTKLNHPRSPKMYIVEPANSSRKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA39</accession>
    <name>A0A4Q9PA39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145341">
        <property type="protein sequence ID" value="TBU51308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA39"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9011" checksum="4A59D92933872720" modified="2019-07-31" version="1">MRSNAFVVKSSVRNGRLGLCAVDTSHCKAESQTTCSGSPWTLSTVTLNPGACSTRCVCGSQGQNLCCASCDHSSGLEPTMELCHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC24</accession>
    <name>A0A4Q9PC24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_952813</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145258">
        <property type="protein sequence ID" value="TBU52289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC24"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="174" mass="18890" checksum="393D86B27B9F0A80" modified="2019-07-31" version="1">MLFVLGSIFGAGLAALNTFKNKLFYPDASNAPSLHINVNLNLGNMENVTVVSPQVNQTVGPQFDFKFIDTSYDLASSSPNASAISLLLQNKTYSADIYPSKIDFIADSDPPTAEAQLNVPLLPGLAEGSYNLTIMEWQWGGPLNSPKSLSRFEVPVIFVFDPKAHEAPPTKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC40</accession>
    <name>A0A4Q9PC40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_259786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="127"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17615" checksum="6877227ACD27D099" modified="2019-07-31" version="1">MPAPICYSVDMERLIEQLCLALRRACRRPRRSVSCVSNFSIQLRVGPIYPEHSCGYDDEYEGAGSRRDGRYPFAKRHADEPLVDDRRAAHATVRTGQCNCVHWIDGGQCVITNIRRCASLVSFHPKSYQATSGSSPRALNGGSRRSRTSLESVAKANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCK9</accession>
    <name>A0A4Q9PCK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_315658</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145287">
        <property type="protein sequence ID" value="TBU51765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCK9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="513" mass="58649" checksum="ADB595DFAEAE69B7" modified="2019-07-31" version="1">MRSETNSDERSKLGVGWHQYTHPEGKVYFRYKNVYTDAWLLDKNTLNTLEAAVAMLCRRLRRVRQDTDGPLLDNIEIGIHLTSQDSDKSGLKGWFRRDKGDPVVKGCYHLCDMTKKEVFWLDEVPAEIFWEDLDHNVVGRQHLHIAAEAAYWEHIYIFPHDRTISQTELHDLREKLAFWTFDAGSSKASTSPYTATELKDFSRIVGNIIADSKRPEDACIVGKLKGALLKIRFAYFFGEEHAQINNSRGVFPHHHDPEHHSYWFRFLNCLSFYTAASYYVNLNHLWIGRKMSTSRWNDFVIQLQDDWYDAITPATVILAANLSFLAISSVDDSGLPPAQRSLGQIVSYISLILNVGNIAASTILARQHRSGHHSSFEGEPPKGGPRKKQLQELERLAVIFSIPATFFWWGLLTFFISIAWICFNRTAQPTRYTAVVTIVLSMFLLLLVILYTYRDNHRSIWAELSALLPLPGFLTCSTSQKRSSSQDPQDQSNNGSTHKGELQTLDTHLDLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDI1</accession>
    <name>A0A4Q9PDI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_831251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145232">
        <property type="protein sequence ID" value="TBU52910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDI1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF1">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="101"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="516" mass="56838" checksum="9083F47310ECEC8A" modified="2019-07-31" version="1">MDASASSRTDAVEPYHAAESIGHGSSADRHADHTAQSPLSRASSGIVQQEVRDDGENKPSRKPSLLPDEPTEVPGHYGFFSPRFAPLRREYFIIIARATAFIMVLMWITLPVYWGALANSAKLTGNLDAWFVSRDTGRVGQGLVAALSKYAPPGPRLNWQVMDPDVVGSDDDLANMVAQEQIWIAVVVQANISQKLSLARQVGDTTYDPTSAIKVFYSQARQEIATGNYLVPLTTAMLQETTTTYATASAQRYFAQINNNGQPNATALQLIATAPQTIAPAISWTMVNLRPYNAPAAQAVTLVGNIFLCIFSFMITMANSTARAIVGPHMDFLPYIGLRILVPLLAYFPLSMSFALINVAFKLPLGTKFGEGTGFIISFAYIYLGMASLGLSLEAMITIFTPRFIPFFLFVLILYNVSPVVLPDELQNPFYSYGNGFPIWSQALRTIMFNTASHLGRNAAVIIAWIIMSCATLTLFTWLMRRIERRRLRALQSRTRSKSPENTPLEIEKGKEKSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDJ4</accession>
    <name>A0A4Q9PDJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_939262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDJ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="252" mass="29041" checksum="8B13D80E80769F52" modified="2019-07-31" version="1">MSHDNARKMTNPAHWYNGQILLEKEPSTDPADLGSKLTQAAEEAQKAKWEMLIANRKPRPIIPPKLLGGHGRKPPLLLYGWTFDSDYFLGLTKRYGLILKVSEGARKQLGCATKRFNFADVTEEHCRDEQLLDELRRAARFVSVSHLTGLAGIPFEIGRSLSLEWDSIIYAWTNYDADEKYFGYGLSQKGIFERAKKLMDEAMNECLPEGQKSELLWWWSFDDNDVVRGFLRNEWIHRRADSRSQNVLTSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE32</accession>
    <name>A0A4Q9PE32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphotransferase</fullName>
            <ecNumber evidence="8">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_921177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the hexokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE32"/>
    <dbReference type="STRING" id="114155.A0A4Q9PE32"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000034">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF30">
        <property type="entry name" value="GLUCOKINASE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5 8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="9">
        <location>
            <begin position="19"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="237"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="10">
        <location>
            <begin position="402"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="541" mass="58726" checksum="A2CC706A2ECEBB68" modified="2019-07-31" version="1">MSNTSYHYVASPEDGRRVLEQIEQQFRLSQDDLTRITSKFLEDFELGLSEYNHPMAMIPTFVTGVPDGTEIGTFLALDLGGTNLRVCEVELLGNKEFVLRQQKYKVSEQLKTGEASVLFDYLADSVDAFLTDFASAVPSSPTNEQVNPFGSPPLSEEPAVPLGLTFSFPVEQTALNRGRILTWTKGFSAKNAVGNDVVQLLQDAFNRKHLHVRCVALVNDTVGALLSRAYTSGGCILGSIFGTGTNGAYVERVDNIKKLGESEARQKGGFMVINTEWGAFNNTRSVLPSTPYDNKLDRQSINPRLQAFEKCISGMYLGEITRNILLSLVDAAPKPLLFNGRSSDVLDTHYGLDTAVMSEVEEAWESGRVPAVSGKDAEHAQILPNGSTAEVPDWQAVKVVDVEQLSEEDVARLERIRGIVIQRLSLDPENVSLRDAAIVRWASSLVANRAAKLSGCAVAAVLVQTGRAKLGGGFATDEEKIGVGVDGSLIQFYPNFQARLRDSLRDLVGEEVEKKVDIGLAKDGSGVGAALCALQATKQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGT5</accession>
    <name>A0A4Q9PGT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGT5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20282" checksum="06E7728B496B5774" modified="2019-07-31" version="1">MPDVRRRWLRRMNWSEVPKCSAGSWSCRGCCRCEERAHHGARPWVAPWSDVDYGRLWARFPVEARNAPASMSRLRVPASDVGGDGARGLRRLRMRERRAAASRTTGAARKTAPAAVVDGWMRPGWCSCERSPFSIGSWGRKPMCRITVGAHTSAAHSSLPSAHHDGLPTLPGAPSQCARGRQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH15</accession>
    <name>A0A4Q9PH15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_971043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145275">
        <property type="protein sequence ID" value="TBU51956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH15"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="207" mass="23236" checksum="B0D64C62AF5B4CCB" modified="2019-07-31" version="1">MPDHTASFQTSFSVRPPRPPHQPPNPLPFPSAVFVPTVAEPLALLRTQTVPHERCKYAISNADIPVQALGYTLRLTTQRPPHDAPLARIGGFCPEHRPFDARWALRDLLVQHDRRDVWLVKRRQPGEHLKDELPEGIPIYAFIVPHVADNVHTAGISNDRGDGQGSRQESWFSPRMQGSLGVMIRVSPDSHKSKIERAYTMVDVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH88</accession>
    <name>A0A4Q9PH88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_189843</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145232">
        <property type="protein sequence ID" value="TBU52902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH88"/>
    <dbReference type="STRING" id="114155.A0A4Q9PH88"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="349" mass="38855" checksum="26DA7F08DD01FE7B" modified="2019-07-31" version="1">MPTIAAPEKILVTGANGYLGVWVSKLLLERGYFVRGVVRTKEKGNAFVKIFEEKLPTHVKNIEYVLVPDISAEHAFDDAVKGVTGIVHIASPLTNLVQDVDFLIRPAVEGTLGVLKSALAHGTDLKRVVITSSVRAVVQAEARTYTEDNWAEDAVKIVEEKKNEANGMYIYGASKVLAEKAAWNFYEKHKSEIVWDIVTIPLAWVIGPTVEDPPSLENIPSTAGLFYLMLVSNPMWDAMNASGINYVDPRDAAEAHIKALEVEAAGGERIIVSSHWCTWQDWRNKAAEYGYFPKLDKGDPKRGADLPRRICSNEKAKHILGIQFKVLPDTLKDTLDYYKTRGWLAEYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHA6</accession>
    <name>A0A4Q9PHA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_938805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHA6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6814" checksum="44B7DE0FE9499164" modified="2019-07-31" version="1" fragment="single">MRHLPFRASERVIFLTASLSTTTATSLVSLSLSSSSTGPPPSLINSGLLSTTYTARFYFLFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHC7</accession>
    <name>A0A4Q9PHC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_830918</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145226">
        <property type="protein sequence ID" value="TBU53087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHC7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF11">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="73"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="142"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="337"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="480" mass="51442" checksum="F0F6F13734B362B8" modified="2019-07-31" version="1" fragment="single">APKKAQKMSLNEFLGDSALGSWADEMDSLPTAPAARADGDGQRGDRRRDDFLASRSDRAPMREDLPLPTEPPFTAFIGNLAFDITELELEEFFGGVRASSLATKSVKIIKDRDDKPKGFGYVEFNDLDGLKDAIAKSGSTLAGRGIRVSVAEPPKERSGFGGGGFDDDAKFAGPWRRDGPLPDLPSRGDGPRRRFDGPPGASREPPPPSLSDTASDWRSSRSAARAPSALSPQESEGSFKRRGPPSREPAPISAADTEETWTKGAKFRPSVSQEGGDRAERPGSRFGSLRRSDVGGSSSVQEESDWRRPRTISRNSTSPNSSTPPTPQLGRRKLELLPRSSASTAPSPLASPNPSTGPRSNPFGAARPVDVSAREAEAQQKIEKEREEVREKVAHAPMSRTSSRTSSQRPTPPTTSPPSNVQSPTTPQSEARALPASNVRPTFSFASAAAGKKDASEGAKDEVSKITEKIDEVELESSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHK2</accession>
    <name>A0A4Q9PHK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_830340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145218">
        <property type="protein sequence ID" value="TBU53287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHK2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHK2"/>
    <dbReference type="OMA" id="ILGHAIC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049555">
        <property type="entry name" value="GDT1-like_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01214">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="293" mass="31456" checksum="875BED4D190181E0" modified="2019-07-31" version="1">MAQDVLPVSDEGAFHALWRSFAMIIFSEIGDKTFLIAAILAMRHPRLIVFAGAFGSLVVMSLLSAGLGHILPALIPRKWTQACAAALFLVFGVKMLQEGREMKGGNEKIQEELKEAEEDIEGDEATHDGTGGVGEGGQVVVPLESIEAGHGTGHVRRRSNSGRPASPRSQTKHAMKTYAESARNFFSYLLGPVFVQAFVLTFLGEWGDRSQISTIALAAADNLYVVAFGTIVGHSCCTALAVMGGRYVSTKISVKHVTLAASGLFLLFGIVYLYEAFLPIDTDKADLHPLSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIY5</accession>
    <name>A0A4Q9PIY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_859160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU54039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIY5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIY5"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="367" mass="41114" checksum="8B68162B7F94B82D" modified="2019-07-31" version="1">MRILSGQALSSLHPHTPESNEMANTEITNSETEANIASTDTVTEAGPPFNKPSADLILRTSDNVKFHVWKFILEEVSPVFAAMFVPGAQPVSSQEKDTTYRDAEDNHGRGQDSATDIPFVHVSETSTVLRRLLLTLYPPSNLQFASLDELGPVLAAARKYQMGAILDCLAEVLVRDFAKAEPLRVYCIATLYDIPLAQRTAARHFLAFSTSEHAKDYDVDELRDIDGRAYHRLLSCRWQCTAALAETLKDLSWFPDDLLFFTNNKSCSCASEKTTYALRGPDGTTVQHNLKRWFFAHIQRMTVVLQDKPSSDGLKDPALCDQTLKDAFNCGTCRGMAFEHMRQFMKLLEDHVEETVSQIITSMFGHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJV4</accession>
    <name>A0A4Q9PJV4_9APHY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_1041819</name>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020358545" evidence="1">
        <location>
            <begin position="25"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="236" mass="26590" checksum="81F7958B127F8C5C" modified="2019-07-31" version="1">MHMLPLKLSRPASCLLWHATLNLAICLLSDDFGLVGLRSLSVEFLQDGNTRSRCSIHLPRVINRTTGCIFISLHLGQPPDTMDTSSKLASEHLTMYELVPAAAGPIRGPQADVHFEIGHRLLDHFRIVADPQTLQASSRLPLIENYGLKKLVSLANIFHLQSAANIFLENLVNAIVQIESVLHFSRESPFSAPLARYQERYLSDAMDYFMRRLAFPMQIRTLRSILRPNLAPNLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKK1</accession>
    <name>A0A4Q9PKK1_9APHY</name>
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        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1041621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145183">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="244"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="632" mass="70419" checksum="201861A2C45205E2" modified="2019-07-31" version="1">MWLLDTDDGSFFWIDRPREHRYAILSHVWRQGGEETFQDLRALQNAEKARKGLKRRLLKIRTPLPSVLSRASDKIRGCCAVARKHGYRWAWIDSCCIDKTSSSELSEAINSMHEWYAAADVCFALLDDVGDDHDPRLKDSKFRRSRWFTRGWTLQELIAPAVVVFFSKDWRLLGTKEQLADLVEQITGVDRAVLRHEIPLDAVSVARRMSWASKRQTTREEDRAYSLMGIFGVNMPTIYGEGQNAFIRLQEEILKHVPDQTIFAWGPTLFDDAVLYKGLGPRSVADDSRYWQSRNLLAWSPDAFITSGGISSISLDTFENRVGLAFSFSEYHVTSYGMRLRVPLIPIQHGSNKTTYLAILACEDAAGNLLALMLFPQREGSSRYYVGHYVGSPQVPPYAYFRAVSLSKARLSEILHTAGIQDVCIPYRASLMGHRKPQPIASPALFKCPCDVVVPGWVASKLREEGFAAAALRENNDDDLTLHISEVTSFADSILVLKSAKETIRIHMGRCPCIGQFLAVSVVGSGDAGLERAATVRSGGMVSGFDNGLLSSRQDKRSIGSLGAVDRPFGAAKIADLAPRCPTGHVAAWEGGSKEFAYGNRTVRLTFSAWLTRQDVYTLGVELGTEEVPEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKR0</accession>
    <name>A0A4Q9PKR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKR0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17225" checksum="EFDA8A48CA1127FB" modified="2019-07-31" version="1">MSNRDYYGGGGQQQYYPPQGASHVMCLAGRGRLMSFARWLLPPAAPASLWPAALRRPALWPAALSASAPSADRLRVRSGAELCLWSSMTERRSFRNGIDNSKTRVAETDAWHVWRECVRSHRDTRLSALSPDRCICAPQNCAAIACSRVVRQALPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKX2</accession>
    <name>A0A4Q9PKX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_935077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU54784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKX2"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13074" checksum="63ECA6B3598DA4FC" modified="2019-07-31" version="1" fragment="single">SRFLFHLQAADRTSLDMDSSDSHEGPPETSSRTNISSIVFDRVVGSLSADIAPEDLLGTADEDTEDYAQTSDFVGTQTEYLEEPMEKGKSEHELQEVNALDCGTRASSSTLRGLDSVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLF8</accession>
    <name>A0A4Q9PLF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_934512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLF8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6755" checksum="04F93888B72FE26B" modified="2019-07-31" version="1" fragment="single">MYGTQQGIARLSFMVIQLCVRGIGDNHPKFLLSHVPQSSGQRLIPSYGTKLLLPRIAEPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLI0</accession>
    <name>A0A4Q9PLI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_826829</name>
        <name evidence="2" type="ORF">BD311DRAFT_665337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143432">
        <property type="protein sequence ID" value="TBU27459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLI0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU27459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9940" checksum="A481E19240DAE7EE" modified="2019-07-31" version="1" fragment="single">EKGKNVAEDGHEITLLFTEEGAIEMEKEREEWCGKCKCAMLVHVPKNSSAHPPNTSSRPTHPHPPPHPKPLESGVKWEIWHNWGWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLI1</accession>
    <name>A0A4Q9PLI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HlyB/MsbA family ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_826863</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLI1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="724" mass="80723" checksum="313EA2A5297B87C4" modified="2019-07-31" version="1">MATMLCESTNGKAHPNGKIPNGGGSTTPPSIRRAHIGVWDFYEAVEDEGPRIPFASLYSKYKDAVECLPYIVRMINDVLSIPGCALLVFAYAATDLIQAFLPAISIWFQGQLLQITQVAIDTRTVDKARLFKICAGRIACSVVGILLYRVRRRVENPLNARIRRWYALHSFHSRARLDLPTYAQPAVQRQVGNASDNMWGRTVVWQTLELATDIVSAATQLAASSAVLFQVLKDHQDGSVLALLTLFGETYYWLSQFDTFKTTRVWLATTFNQDYMKMQGWKKAVRDSLHRKEFIAGGLAGYATAEFKKAAERVGDMDADWNEVEDQILNRSSAWTILKEPLTHLPQIYFTLRAAQAPASIPLSLASLNLIQSATDRFAFTVYEIIRRAQSVGHQLESVKKLYEVVNIPNLVKDGTKPFPEDQNQIRSGIELEFRNVSFKYPDTENWALKNISFKLLPGQLCVIVGANGAGKSTILKLTTRLYDPEEGEIFFGGHDVRTLKLDDLRRAITVLFQDYTLFPLSIRDNIALGDPTTTNASTSDVDERVERAAQLAGADGFIAKLPDGMNTYLDRPVDDEYSAAVEGTKRFSGRMVDYEPLRAAAGIKKAGAAAGLSGGQMQRLAVARTFMRSVVKEDETVGMLLFDEPSASLDPAGEHDLFDRLRELRGSKTMVFSSHRFGNLTRHADLILYMDETGIVESGTHDELLAKKGEYARLWTLQAQAFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLQ9</accession>
    <name>A0A4Q9PLQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_1030826</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLQ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLQ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU55139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="553" mass="62069" checksum="0674A1F0F6F9C2A6" modified="2019-07-31" version="1">MAYTVGGVPISLVAGFVGLVWLVRKKLIAIYVTPIVALRGPPSPSILYGNFQQLGKVADPTLLQKWMDDYGPTFLARLFILMPCLWTADPRAINHIITQSGKYFKPRDGRKQAAQILGESLIIAEGESHKRMRRVMNPAFGPAQVRELTSIFVEKATELREYWKSAMAKEGGTLRVNVIEDLSKTTLDVIGLAGFDHNLDSLKPGSERKELNAAIRHLFKKPPNMTVFRVLLDYAPWLNLFPDERLRNLIEAQKVMRRVARQLIEDKKAAIKASSEDDEHVGRGSVHGRDLLTLLIKANMASDIPVDQRLSDDEVLSRETRSFCDAQYIPSFLLAGHETTSVATTWALYALSESPRIQRKLREELLAVPTETPTMEDLHALPYLDQFVHETLRLYPPVTNTMRAANEDDVIPLGEPIIDKKGNVLHEIPVAKGTRIVIPILAVHRSKAIWGEDALEFKPERWENLPETVSSVPGVWGHLLTFLGGPHGCIGYRFSVTELKALLFALVREFEFELAVPHGDIVPMGLLVQRPVVRNELNKGSQMPMIIRPYQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM23</accession>
    <name>A0A4Q9PM23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_792499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145172">
        <property type="protein sequence ID" value="TBU55269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM23"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20209" checksum="1A037878BDC92FAE" modified="2019-07-31" version="1" fragment="single">MASTSSRHALCTCPPCKQLDPIGQWIPATTALYHERMARRIESPAYQRGRGRATVTGSHARGATLRGGRGAISNVLRGGRGGPPAQSGAVSITSSVPASIPIKRARAPSPLNTPLRDEALESSLMPFDDLVPADIDYPIDEPAGRLSVDDLTTYFPHSADLLLDGGDDAPMLQAMISDERIQLNTSDPQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMJ0</accession>
    <name>A0A4Q9PMJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mis12-Mtw1 protein family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_825822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMJ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMJ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013218">
        <property type="entry name" value="Dsn1/Mis13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14778:SF2">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN DSN1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08202">
        <property type="entry name" value="MIS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="591" mass="65170" checksum="02D7ED1438D790E5" modified="2019-07-31" version="1">MIPIQPQASKRKATDDANPLAATAGKKLKRETSKAGPSTKRKLNGEEQPGGLVIVRAPAPTKNSLHIEPVPAEPRAPSRQPSAQPQSLSQPQPQSSRPAAKKLRADGSSRAVGKAKDRDVYATTRADPEVDEDVRQMQSETDTLRRKSQAAEQAASSLNADVQFPPRTPRLPSSSSRRDVDTVAPLAQQETPQIEKNKVMRGETGHRRRSSISRGKRASSSYEATGVISHPHTSVSVSSFFKHIDYELPEPQRARQLLIWCSNRAMNELADQAPQASTSRRTSTNSGKDPPPLSTAQAGVLKRTQENLMRMLAEKKVDTNVYGGAGSQNGDAQRPLRENEQNIKNRAREARFNAHIQRSKQEAEAWKELSDSYDSHRKSVQAEMEKRRRALATAKSKGKERASAEDLDDWDVERRDLPEQFLSSGSVDVARKLVFENASRSTPLHNRLKELEHTVDRLHTFANSALQTTRVSEADFDRRFALLNLSLASRSQPALSSTHADTTALSSYILPLHPRPPPTDPQDLLRALSRIDADRPQTQVGDAARRAVREVQRVADATAGMAERRLTGVPPPTPRKPPGTPRRATTPGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PND1</accession>
    <name>A0A4Q9PND1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation factor 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Eukaryotic elongation factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_855989</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PND1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PND1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <feature type="repeat" description="HEAT" evidence="14">
        <location>
            <begin position="251"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="453"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="694"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="16">
        <location>
            <begin position="823"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1004"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1008"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU55792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1093" mass="119025" checksum="00DD3DE218D04DC8" modified="2019-07-31" version="1">MSPVAMSVASDSHFAPFLDALRTAPTGPDAKAASDRLAREVSNVGLDSLSDVNILSTLHAFATNKKSGYERESAAIAFQSLATILGASAAPLLLPSLSVLYDLYMDKGDVVRIAATAATKNILKLFPPEATRVVLRTLEDIMDKAKWRSKVGVLDAIRSFASTSKDAVANELGTTIPKIEAAMHDTKAEVSTAAVKCATALCNTLANPDLTPHVPALVKCMSNPDSVPQCIKSLSNTTFVAEVTAPALAVLVPLLIRALNDRSMEVQRRSVVVIDNLVKLVRDPSVAATYLSPLVEGVEKIAKGAAFPEVRAFAETALTTLQKSGASKDGPPPAPRDVQSETADVLSTLLTLLPEGLAATSADAPNGPRTPRHPLLKQVLEFSAGIIADLVHARNFSDAQAWGRSLGTYVEPWFPAGSTDAAKFTERVRTHFLAVDEEKHGGVVTGSTEEGELLCDTLFSLAYGALLLLSHTHLRLFRGRRYGILGTNGSGKSTLMRQLRDGKVENFPPQDQLRCVMVEHSLQGEDTSLSVLDFVAADKALAHVPRSKIRDQLLEVGFDDARQEEVVGGLSGGWKMKLELARAMLYNADLLLLDEPTNHLDRASVQWLEKWLIGKKNVTCLIVSHDSGFLDNVTTDIIHYESKKLVYYPGNLSAFVEKHPEAKSYYTLAATSVKFSFPPPGSLMGVRSNTRAILKMTNCTFTYPGRPKPSLFNVSCALSLSSRVGIIGPNGAGKSTLIKLLTGETEPQEGTVYKHPALRIGYVSQHATHHIERHLEKTPIQYIQWRFQDGHDREILEKATRALTDEDKALLETEFVGKNGQRRKLELIMGRQKLKKSLQYEIKWRGLDHKFNTWIPREELLQKGFGKLVQQFDDLESSREGAGQRDTSAHIVRKHLEDIGLDGDIAQYNEIAGLSGGQKIKLVIAACLWNNPQICVLDEPSNFLDREALGGLAVAIRDWAGAVVIISHNEEFVTALCPEIWHIDGGRMTHKGKIAVVEDAFAVKSPKGSGSNTPARTQTPALSRNQTPAASVAATPAGSGAEDNKANGTATPPVKKKKKLTRNQMKAQEERRRIRKLNWLTFGGPKPEDTDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ33</accession>
    <name>A0A4Q9PQ33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_633928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ33"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16774" checksum="E2893667CA4CCFD2" modified="2019-07-31" version="1">MVYYGLSEPQTELQVANSSSTRRSQISSRRRLTFLISRLDSLPSPSLETASNPCIDAQAHLAKGFPESQAEGMADGADLVGNLQYLCGHSLRFYSFLWPFANNARHRKWLPLWRRHARLDRGWGPMVSASTCCAALANTTPQQSLLDIYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR45</accession>
    <name>A0A4Q9PR45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_823165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR45"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="52"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="485" mass="54270" checksum="807BC092926A944E" modified="2019-07-31" version="1">MASSKAASLVDVTERSDAYDELTNAEDEDAEFGGREARQRLERKLLRKIDLRMSILIVIYILNYMDRNNIGAARLRGLETDLGLEGQEFATLLSILYVGYMIMQVPSNMCLNYLGKPSIYLPTCMVIWGIISILTGPFVSALLTRFFLGFIEAAFFPGALFLLSKWYKRSELGTRIALLYCGNIISNAFGALMASGILDGMDGKLGQAAWRWLFYIEGSLTIFVALCAMFILPDFPSTTRWLSEEERRLAMRRMEEDAGVGDEGETEEGGHSVGLRLALGDWKVWWMALAMTSITVALSFNAYFPTLSATMGFNPTVTLLLCAPPFVFAAIVTYLVSRHSDVTGERFYHTTIPFLIGIVGFVIAVCTMNTPARYVSLFLMAQSYAGYVVVFTWISNSFPRPPSKRAVALAFINAFSEFGDVAGSYVWPSAWGPTYRKSYGICIATAGCMIVMCYVFKLYLERLNRKLAEDDRRKGVKDRGFRYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRI5</accession>
    <name>A0A4Q9PRI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1022090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRI5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23866" checksum="8541922384986C6C" modified="2019-07-31" version="1">MFPNNDRLNSSRPSPSNPPTMQSLALPVEVIESVIDCCSDDTDTILAFALTCRDLHPRSILVLLTDVRPRSRDRLFDLCDVLKAKPERQPIVQSLSIVWDEFAPYPLLSILPALRHIELWSYDSPIRCHPSTVLCCRRFGCGIRSLTLQWVEFSTCTAFLQFLAAFPSIEHLTCRRLFIKQKGEASPLVQKSLSRQLRLRTLDVSLRIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRY3</accession>
    <name>A0A4Q9PRY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_570304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRY3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8097" checksum="2FDA6A9DBDE4DD6A" modified="2019-07-31" version="1">MLSVSSSRLLRSPGSARDHLLRLRRSPRKIIRSLHLKSWPSVVIHGMRTTAARRVQRSIRSFSGILIALRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSQ6</accession>
    <name>A0A4Q9PSQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_929371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSQ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020725820" evidence="1">
        <location>
            <begin position="19"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5423" checksum="8B94D60F1BB7C306" modified="2019-07-31" version="1">MRRALCLVLALLRVTVWALGTGAISKDVEYGAYLKRATRGGVVSSIGGLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTD6</accession>
    <name>A0A4Q9PTD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transmembrane proteins 14C-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_928627</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTD6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTD6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU57747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="9388" checksum="08BA2AFDCF744BD8" modified="2019-07-31" version="1">MGTLCVVGGITGFVRTKSIPSLVAGVGVGVLYLYSADSIRKGTANGLEAALGASALLLLSSLPRASKGPVPAVLTVTSAASAYYYGKTVLALRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV85</accession>
    <name>A0A4Q9PV85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_819584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="311" mass="35271" checksum="BD4767BE8CBE3F3A" modified="2019-07-31" version="1">MESTINPPSDPSTHSVAPKLPSLMFDARLVLEVSPYLETLCLLGINWDAAVPEPAEYYIRHLPFRCNGFPCLRELSISGMHTHLFKNISKRRGPLFPALSRLHIMATASNPVNFGRWLREAPHLSELRLQVTMSTSDGLIPKWMLSLERSLKRDPLSLSSDPSFLMLVLVKQEVAVDISEDDTHPSPAYQQHRARLSRLLRCTSSALVPVILVMNYIPFDIVPEQSGNDWSDVEVLQADWLARVSGTNGSSDFWSDWEEHRKELGDSRLRQISGKMPVVMPNRKAQRRVLLAQLSAQLNRLRREYGLEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVK5</accession>
    <name>A0A4Q9PVK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_967581</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVK5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU58489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="218" mass="24197" checksum="B35D44A350646D85" modified="2019-07-31" version="1">MDVTSIALSPAMWLVNPITVFQSIPAWLGFFKAPGLGSENIPGLNRWRADLEELRTKPFSLAKVGFSNGLFKNSYVSSLLAEGTTGEQSIVDTAAVAFGACYETTVISGDVFILAMVLYPEVQKRAQDEIDRIVGNDRLPDFSDRETLPYITALMKEVLRWHPPAPTGIPHMLREDDMYREYHIPEGAVLIGNIWMVAQILRESFIICIVPGTGQVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW75</accession>
    <name>A0A4Q9PW75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_450046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW75"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="10167" checksum="035214104A6B7DE4" modified="2019-07-31" version="1">MRRFQEQPCGWTLDDAQEPCRLFPMYRRGDPVCAWPYTKPRRPLFNGGMRWISAAFVSGLVIRFYYHKLDFAMHLAVRRIGKEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXR7</accession>
    <name>A0A4Q9PXR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">chitin deacetylase</fullName>
            <ecNumber evidence="12">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_429851</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="12"/>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXR7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXR7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF135">
        <property type="entry name" value="CHITIN DEACETYLASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="8" id="KW-0170">Cobalt</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043377597" description="chitin deacetylase" evidence="15">
        <location>
            <begin position="22"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="367"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU59094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="446" mass="46799" checksum="4507ED4464598253" modified="2019-07-31" version="1">MPPSVIHSLLLLAAALSAAAAVTHDSHDHDHALDKALPGRWYHDDDHPAHALFKRGATDGITYAAVGSPEWSAGFPLKVDPNALPQAWVDAYNSAKSAGKIPTNVPVATQSNGGNPTYGNLDPNGNVVCSATYKCRSPGDIWDAPDGVFGSSFDDGPLDTSQALYELLHENNLKTTHFYIGTNILWYPNEFLYAWNTLQSDIAVHTWTHPYMTTLSDLSVVGELGWTMELIHNSTGGRLPKFWRPPYGDADNRVRAIAKEVFGLTTVIWNQDTEDWSIGSPGGATRDAVNANLQKWITGPKSPGLIILEHELSNETVGAFIQAFPLIAQNGWKFQSIAEINNTGVYQNSPDDNGAVVLGTVGVPASAPASTTPSSASAAPSNATTTKSSSSGAAGNNAASTTGTSKSAQATGSGDASHNGAGARFASPMLAGIVTLLSVAGAALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q029</accession>
    <name>A0A4Q9Q029_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_815048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q029"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="411" mass="46960" checksum="9FD2D2808B937087" modified="2019-07-31" version="1" fragment="single">ITRDGKRCRTDDANSSDEDVDDSQPELVDTTTSVQPKNPGWVIQAWSCNATANEEARRSSGVEPMYDTARQIGRCSTEYPDQTRALAYGVIFRGFDPENRPDYIAEYYSEDVEARMVYLVWARYFPELEDHLEYLAENPALILHLGNYVKTIAGKVRSDDLGRLNHDIVTYSRLEDPNDILQRHSNRGFQDPRTGRLLCPVRYLKEFEAKPAHTCFLFKDHHYKLFSYDFPSFMSDLSRGRDISLADPDDREAGFLRGPLLVSYYKAIFCGRSSVYGKGSSRGQQSVAVKYGMTEVNIHSIAYVALLARSVLGSDAVWRDRDSKHWQAPSFVHAVMDLAHKSPSWKQATTMWWNKQVFGTEDDDDSETERELQESDYYKIIAQRTARNASLIPALELPAEEFQAIEQPSDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0Q8</accession>
    <name>A0A4Q9Q0Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_905361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0Q8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU60396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="410" mass="45740" checksum="B2B0F3FDF3C221CE" modified="2019-07-31" version="1">MSGTTNTEAPFKLSVPDADLELLQKKLELVRSPDELDGAGWDYGVPLAEIKHLTEYWKTKFDWRKAEAEINTLQMFTRDIEVEDFGTLNVHYVHQKSDVKGAIPLLFVHGWPSDFFEVRKILPLLTAGGADHPSFHVVAPSLPGFGFSEAARKPGFKGAQYAELLNKLMLSLGYDEYVYQAGDWGHIVGTHVVKHYGHKHVKAWHTNMPMVTIPTPTRFPLVFIQTLLTLPFDRASKDRLASVRRFAATARGYAAQQSTRPQTIGYSLVDSPVGLLAWIYEKLVAWTDNYPWTEDEVLEWISIYWFSRAGPAGSLRIYHEMSDGGTQEIATSAGWTSVPLGVSYFPAEPAQFPKYWSHTIGKLVFESEHDAGGHFAAFEVPHELADALRRMYGKGGPAHGVVAGKSGYDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0R4</accession>
    <name>A0A4Q9Q0R4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_921990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0R4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="449" mass="50181" checksum="52BA3B6E2AE67CE1" modified="2019-07-31" version="1">MKNTLRPSCPDFVLDWVKMYGDKEPYNQNFDKARYADVPTCVYANPNYWFTQRGERKPEFPLEGHQPFTPGPLPHVHISDWRHLGNIQDQQQEQVKERKDSLLALVPHGGGREMNKAAKKIAQCFQEFLNSLRFKSYGGQSVDVTIHPPDPRNAGGPGSKNPFAQPWTFYVDIQEDPLDLMREFLLYQEHFAISPACSFSIHPLNSVNPQSWKLLVLASPYIMGPGAPHNSVIAMREATRRVVIDKLKAHRGYREHIAKLAANHIGHTGDHEQVFKTITDTYHLQPVVAETKDGETSAYILYARPLTSTRKENDTLKDLIREALCGVGSEHFYVNMRKIHVIDDSKKGVPPVVDCKLCKSETHTTAACPLPKTRGWRGLNATDLGRDGEPTAEKAGTSRDDQHATMEEVLNAIRGRTATSSPKGKKGRGGAAGRGRGQYGRGGRTANRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q184</accession>
    <name>A0A4Q9Q184_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q184"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="50314" checksum="26FB1CEAD042FBCC" modified="2019-07-31" version="1">MLIREASRIRELHFIAPITRDLPSFLTSFDASALQHCLLSAERGSDSLTRNNARFFPFFSGQGSSLRSLCFHDISVLPANTFPCLTLMVIRLKPNDNYPVNWDLYDLVNFLSGSPRLEEIYIGDISWRMEQVSFSLVPVVRAPLSLPRLRYLSLTYSARATESASHVVEHLLSRLIIPPSCHLYFKARGGPRNINQVLLESVRRHVAGRDAVSHVCFWITEFSCDQSIQLVFPKGSLRLVFAASSFNPVRYAEDMFDLLCSFPQLFTETQELRVHYSENNLLRKLQPSLPAIFPNITALSLVPFLVPGYSGHASLTIGLESLTELPEGERKVTWPALDTLWVSVTDKRDATQLETALDFRASRGHPIRHLTVRYDPRKKKGKGGVENKVPSFAAALEEHVKEITLMELSRHEPSREIDWMVRLPERYGLPSAFHRDWPSWNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1I7</accession>
    <name>A0A4Q9Q1I7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_922958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="12">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NAC-beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1I7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1I7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000003">
        <property type="entry name" value="Nascent polypeptide-associated complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0678">Repressor</keyword>
    <keyword evidence="10 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU60434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19218" checksum="87056D3BDAD40486" modified="2019-07-31" version="1">MDPAKLAKLQAQAAANRIGGKGTVRRKIVRKTKPSTAQDDKKLQGALKKLNVQPIPGVEEVNMFREDGNVLHFSTPKVHAAVAANTFAVYGAGHVKELTELVPGILNQLGPDSLASLRKLAESYQAIQQSQQRPPAGGADDDDDDVPDLVDNFDAVEDKPAAEGEAEKEEKKELEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3G7</accession>
    <name>A0A4Q9Q3G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_148265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3G7"/>
    <dbReference type="OMA" id="YLRIHEY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="40901" checksum="0D7140860F927B0F" modified="2019-07-31" version="1">MPPHLSSLRTQMLPAEIIFDVVREAWLTIVNGDWALRWDFYNSISMVSHSFNGAMQNAALRIVAIRTPEDFKAYRCLVKRRWGLDPDYEGDNERVHPDATGFFVRSELHIVLADWICPGSGFQYRTDYVRIARYIPACKSLHVLVKELPSNDQYTLPYQPLFHFLSQYPDTRRMSLRWTYTHSNRYILPKFSVEGVTYLRVREFPRCICHNHRPSPPPGKRHYDDCFSYYLMTLFPNLSHLHIDTPYFLKNLTTPPNVTLVTIEVPPVHYSTSHGQFSSLSAWNIVSALTLGFFKTRVDPEEENPPPPRRRKIIVNTGPQEPQGWAVAVAACKAHNVELELRRVYNNPVRDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3G9</accession>
    <name>A0A4Q9Q3G9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3G9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8868" checksum="333853D102907E1D" modified="2019-07-31" version="1">MLTQWTQESKTKLMRRYRSPVSSAYVLIGFGVVQLLRDSHDWHYVSRCRRQSVSQHTQSSGEPHVFLRSRCEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Q6</accession>
    <name>A0A4Q9Q4Q6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1036696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Q6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4Q6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="28748" checksum="B1F735AFF9BCA324" modified="2019-07-31" version="1">MPHPPIQVFLTTIASQPALRQRQDKQQLPGLLIGGEFPGTFQDFEDAVEFNELDQFLRLKEEWDPLEEDRPILRAVPVGIPGAYSPAQMNPEHISPAPSPIKTKASRREGESDAGELLGDANLHGVDVTEDDLEALVKELGLTGADAEDLVKGLSGEDAKKDATPPPPPPAKLEITAPVEEEAPAPPAKEEEPAVEKPQGPAGETPAAADVEKVEGSKPEEPAAKEEAQATADQSTEIEEPAKAGEVKADEPAKAEPPAETSTPLAVDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q510</accession>
    <name>A0A4Q9Q510_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Signal peptidase I family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_811882</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q510"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q510"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="82"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15455" checksum="BA52C535D233965B" modified="2019-07-31" version="1" fragment="single">LHLFGDHIATISHVAGPSMLPTMAIEGELALDWKWIDVNRLSRGDLVTFISPLDPGRTVCKRITGLPGDVVCVDPTGLAAPSTEHVVVPKNHIWVTGDNLAYSRDSRVYGPVPLGLVKGRLIAKVWPLSKFGVFPNTFDFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q532</accession>
    <name>A0A4Q9Q532_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_797648</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q532"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q532"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF4">
        <property type="entry name" value="AHPC_TSA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="2"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="11">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU62359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18026" checksum="509DEDE7D559F1D1" modified="2019-07-31" version="1" fragment="single">HPLVGKPAPAISLPAADGETYTLTPGAKGVPVALFFYPKSGSYGCTKEACQFRDALAEKDLFKRTKVEIVGVSSDAVDKQKTFVEKQKLTYPILSDPDGEARKAYHVGKGLFGLAETARVTFFIDSKGTVRDVLDTTLNYSAHVKFVSKWLDKLEAEEKKAAEAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5J4</accession>
    <name>A0A4Q9Q5J4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919275</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5J4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020632121" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="18420" checksum="A834805A8FDC2607" modified="2019-07-31" version="1">MVAFKYSAALVTFGLSICTGVGARNIFAPRRPECGVDPAASSIITVTSTVTSTVTATPRTRLAKRTTDAITTITDTTTTTTTATDTTTTTTTSIETSVTSSSSDSVISPSAPLGNPYFRPHSTRTPRSTETASSTGSLPSSVSSSASSDASSASSALSSASSVASSASSVASSTSTGDLSTTSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5R6</accession>
    <name>A0A4Q9Q5R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L18e/L15P</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_917891</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5R6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5R6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="186" mass="21312" checksum="AC4F0F8E8B995035" modified="2019-07-31" version="1">MPTRFSNTRKHRGHVSAGHGRVGKHRKHPGGRGLAGGQHHHRTNFDKYHPGYFGKVGMRRFHLTRNLQWRPIINVDKLWTLVPAEEKEGLTESSEVVPVIDTLQHGYAKVLDSYRVMRVREGRIAQRQMSCWIATILRARSPYTPNIAHVRCYRLPKLPFILKARFVSRKAEAKIKEAGGVVKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6C7</accession>
    <name>A0A4Q9Q6C7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal pheromone mating factor STE2 GPCR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_124789</name>
        <name evidence="2" type="ORF">BD311DRAFT_709874</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6C7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6C7"/>
    <dbReference type="OrthoDB" id="3232296at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="39823" checksum="63E4BAB41D8507EE" modified="2019-07-31" version="1">MHTEYDSPDNNNTISQMSVLAADVGFGPYAKEIAYASFSLATAGQIALLVVILMYFRSSETREQNAPWLNMLAVTLFSTIPPYLLIYGSAIWVPEPPSALCVTQASLIIGTAVMPAMTSISLVWDVMVEIRSMPLNESTAKGYQTMLMATPYIVFIAFSVTAAVLSLIYPFKVSRHPDDLACALENVPLNIASQILSVSVLLMALCLEVHTLVTVLKLRRRDMSGDRRPASFNSSKTVRIIVLTCLQALPLIAMGLRTHLDFPRLRVVAVFAEAFLPLGTSITSAPQGWRKHQVFTWLKKRDDNASRAQSTQQSSSLHVQIVVTIEHFADSERKMPSLLAQGLTEHPQDVLSETTEKPSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6T7</accession>
    <name>A0A4Q9Q6T7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_945226</name>
        <name evidence="7" type="ORF">BD311DRAFT_774707</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6T7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6T7"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU33061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="565" mass="61816" checksum="2003F55B29FAEDA6" modified="2019-07-31" version="1">MSSFSLPQINDNPDGGWGPSSSTVPAQFKFKDIPYAPYSKSDKLGRFADWNDISGDGRPTNLGLSSTQTTRGGGPGRRGREGQQAFGSGAASAFAYFHAEDESSFSVVDSKATATRRGGPMTRGRSTGRGGGYGRGGNSQRGGRGGFSGGRGGGQRGGRRGWRDWEKNGRTRESSVAISPDWAMLEEIEFHRLAKLRLEVDEPEDLQTYGRVYPYDKTYDRINTRNEKPLQLLDRIKYNPTTSDDPVIQGLAANDTATIYTTDVILSVLMCAPRSVYPWDIVVVREGNKLFFDKRDGGPFDTVTVNENAADPPQDPTTVNPNNPNEKIAVPETPSINSATSLSLEATYINQNFSFQTVIETPPPPAVDFSKPNPFYGPDETEPLASCGYRYRVFDLGVTEDEDIRICVRTEVDAYTPGQDPLQGRGLVTIRALNEFDPRAAGAGGAPDWRTKLDSQRGAVVATEMKNNSCKLAKWTVQSVLAGADVLKIGWISRVNPRDNTRHVILSTTSTRPTEFAGQLNVSLANGWGIVRTVADMCMKQPEGKYVLIKDPNKMCHTSLLPYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7T5</accession>
    <name>A0A4Q9Q7T5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_582184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7T5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11428" checksum="27FFDCD1DC556F0E" modified="2019-07-31" version="1">MFLAICYHTGSRCLWLNHRLSLCPVVACSIHHQCGHEGPSLTNGFAAGQGPSVREARLALSWTSIPQKTRTGQPTWLTAMVRLVIVRNAMGMRRHQKHDVPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7W1</accession>
    <name>A0A4Q9Q7W1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1308 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_973669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7W1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7W1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379">
        <property type="entry name" value="UNCHARACTERIZED DUF1308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13379:SF0">
        <property type="entry name" value="UPF0415 PROTEIN C7ORF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="495"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="647" mass="70960" checksum="3FCC82B472F9476E" modified="2019-07-31" version="1">MHHPELQGLRTQLRQIHAAMVAFGTAPLSAKPPILDSSIDLNGETNEEFHSHRDAVHGLRALRDAVKRDLDVLEKFLDDSACATAPSLSTNAPYLISVWNEVLYAPPPIVTIWRTFLEEDKPAHVPRRGSHKPPGVKVDIVADGGRRWIRVNTTKNSRLLAEFREIDSYLTDSEDEDGEGERPSLAQKTFDNSILRVGRSLLDAARRNPLAGTSTIPSITLRFTRLNMTPTDAREYDPRIARTVDLLRDMGIDVELGERDPAQLPRVVAPPVRHLEPTVCVNLDLSILIALVSDITHSPLPTSPAEANARYVPSAQYREWKRKRLEATKGPVEGIDVDENRPGETGLGAHSRALANQALQEMGRGLLQELRDRLNALASPGLENVEFWTTPEARDRCLRIVLSKIGGPNERRRVAALFPAADVPLSEAQDRYWEDSRSPHAFLPLIPVRVFESPVQDDALEPPSLSDDGRPLSPFFKLLTRTCRDILAQETIADPRTTPSSRASSPPTSLPSHERGDDHQCGESASTLALESADLAEETIERAVVTKANPRLTAHTVQSMLWGAARGWTTLTANKSSVKAILRDIRAAEGGYGWSHGRDEHGQVEGANAEGGSVEGDGAGAVVEKAAIWVVDPRSLAEGMRSDCTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8K4</accession>
    <name>A0A4Q9Q8K4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_944973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8K4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8K4"/>
    <dbReference type="OMA" id="FIAGWIW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22490" checksum="2858DAC98674D84F" modified="2019-07-31" version="1">MSRITLPASSRTIKDDRDYGLPPRQRRLEAGQSVFINGGSTAVGSFAIQLAKAKGAHVAVSASGKNEEYVRNLGADEFFDYTKAPLHEQLIAANPNPKYHAFFEAVGTADPALFVESDRYLKFLWKVLLQPSWLGGTKRTWKLIFVVPTKKDLEAFAKLVEEGKVKPLIDSVFSFEDTLKAYERIKTGRATGKVVVKVDPTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8Q3</accession>
    <name>A0A4Q9Q8Q3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H3-like centromeric protein CSE4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">CENP-A homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">CENPA homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_1013625</name>
        <name evidence="16" type="ORF">BD311DRAFT_653511</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8Q3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8Q3"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000087">
        <property type="entry name" value="Probable histone 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF17">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="66"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU63922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18518" checksum="2CA48B427CFE26DC" modified="2019-07-31" version="1">MAQTVQRGKRRQAADDSPPSSPPPAAKRRQTATARKSTGGRPPARGPSDAGPSNAGRRASGKRFRPGTVALREIRKYQKSTDLLIRKLPFSRVVREIALDMITDTVEYGDNGLRWQSSAILALQEATEAFLVHMFEDANLCAIHAKRVTVMQRDIQLARRLRGSSGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q906</accession>
    <name>A0A4Q9Q906_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_808017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q906"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000039">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.13, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="219"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="368" mass="41042" checksum="A590B69A9FC21FB9" modified="2019-07-31" version="1">MADATLPIINLDVFVASPESEAALKECKKAADALITYGALLLHDSRVSEEDNNAFLDLIEDYFAQPEETLKKDERPELGYQVGVTLENTEKPKCAVDEPCLKVIARLDPAERPLDITAHSPDPKCRFFWKMSEKPPYESQYPGLNAPNVVPEDENIRERWTPIMEKWGTSMKTAVANLSEMAAVGLGLPRETFKDAGKYGPHLLAPTASDLKKYGQKDTILAGFHTDLNFLTIHGRSRYPGLNIWARNSGKRIPVRFPATGRYLLVQAGKQLEHLSGGLVKAGYHEVVVNDATLQAIERRKAGHPDRPLIRISSTFFWHLSSDYDLAPIPALQERARALRADAITLGKIDLEEETAYEPMKVGQQVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9A7</accession>
    <name>A0A4Q9Q9A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_973123</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9A7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="485" mass="54049" checksum="824BB97C16C952FC" modified="2019-07-31" version="1">MAPSKAESLIDVTEIFVELTSAEDEDAGFGGCEARQKLERKLLRKIDSRMSILIVIYMLNYMDRNNIGAARLRGLETDLGLQGQEFATLLSILYAGYMIMQVPSNMFLNHIGKPSIYLPTSMVIWGIISILTGITKDFVSALLARFFLGFVEAVFFPGALFLLSKWYKRNELGTRIALLYCGNITSNAFGALMASGILDSMDGKLGQAAWRWLFYIEGSLTIFVALCAMFILPDFPSTTRWLSEGERRLAMRRMEEDAGVGDEGETEEGGHLTGLRLALRDWKVWWMALVMTSFNVTLSFTTYFPTLSATMGFNPTVTLLLCAPPFILTGIITFALCRNSDAIGERFCHATIPLLFGIVGFVIAVCTMNTAARYVSLFLMAQSYAGYVVVTTWISNSFPRPPSKRAVALAFINAFSSFGNVAGSYVWPSTWGPTYRKSCGICITTAGCVVVMCYIFKLYLERLNRELAEDERRKGAEDRGFRYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9G8</accession>
    <name>A0A4Q9Q9G8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_389629</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9G8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12476" checksum="D4DC305F5DED69D3" modified="2019-07-31" version="1">MSGLRPPCDEYRSWVTYQSPPVRAKTAPNSTTALSTFYKDTRFSLTSGEQESRTSCLPKSTPTSSYDIVPIESILSTSPVCCLQVVSSWGAPPHGWGCDTSAAAFGMHSTLLNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9L0</accession>
    <name>A0A4Q9Q9L0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_868463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9L0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="26643" checksum="0EAAF64F42F83459" modified="2019-07-31" version="1">MYAPSSPQQIHLEDNSFSSLDTKVQTAIISTSLHHLQQRYHHYHQSSSPSSSLSCPAQSASPPSANEPLSSPSSDTPSPLPSSVAPQQSEEEWGTPHLLLDLSAPPPTSNSDITCSTSSGKPLDPTNPAVRRARHWISAISSFLKVHRAKEKPERPVVQQRFREMIEAIKEIEEEKDLMSYNIVVSTQLYHAVRRLAHANVIGQKTRPSDLARKVLECWKGRFPGKLPERRAGAMEADDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBQ7</accession>
    <name>A0A4Q9QBQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914929</name>
        <name evidence="1" type="ORF">BD310DRAFT_919344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBQ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6988" checksum="47C83B4E73EF3C72" modified="2019-07-31" version="1">MWRPAVDDHAVARATDHEPLAWRALVHTYCRAPCERCMISLLRMPLPMMPAPLEITRYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCS6</accession>
    <name>A0A4Q9QCS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1001876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCS6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCS6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050471">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433:SF10">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43433">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="565"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="761"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="764"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="895"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="930"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="941"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1081" mass="117809" checksum="9A2D7F07275A96B5" modified="2019-07-31" version="1">MSTRVQAEERSLANGGGSWKSPKKPSFLSLRREHRSPEHEQSSPSAGGTRSHAEKPTSPSSFHAFQDVSRPVISRPQDLGGRHHNRRPSKQPSLRHEQSFPKSSRPREWEECDREDDTQGNFFDFPSVDERPTPSKGYESTNARSRTRSGPTKRSAYSRDSGGPYPYPLRDSNSSTLSHLEDAPQTPIDDPFLRDPIFGIASVVVAAPIAGVETMDALVDGMNEFGNDDHFMGLRGMSGRSSKFTKTGFHPLYHPPLPTPPPGVILGGARPRKHSSRSRDSDADEDEEEPARTRSPPPRPRKSPHRTPVRTASSTTVTSNTSPRPSTSPSVTDLSKQFPSPHRTVAPSISDIIRAHAPLEHSSRSRKSSYATSHGHDSIAPTVSSLGKHREVSQEPAAPPVDEEGDLVSRSSVDTLAEEIQRTIQAEKRSSVVPRTVHKARSFQQHQQHTAPEMTRTISSPRSDSRRESSIYSYNTTISDQPPLPPLDLMGLTKVPVNSPSQTIAQYLRSTRLTTLLRLTRSPHASRGNPLTVSLSDLGSPTGFPVVVFLGLGCVRHIMGLYDEMAECMGIRLITIDRWGLGRTEVPKSKSARGIPEWSSVVEEVLDQLDIGQCSVMAHSAGAPYAMAFANRYPERIRGDVCLLAPWVAGGEGGGYKWLKYVPNGLLKTAQAAEWKVQAWMLGKPPTIAFEGIGFNAKSPISSPPNSASSSTSALNSPPTTASTVTRGKMAAGQQEAEPRPSISSAAFSEYDDLRDFEGRFDSRSTLGRNSSSSYRNRTISDSRCGNPSTATRKPSKGFLGRFKSGNQEAQSPSNAKSSNGPAKKLKALRSMGSLKGRSRGNTPKMSDPPVPTSQWIPTPTLSDNAEIGLGLDQFDWTDPAMLETGPPSPASMKKPRDLPRLDLSKDGSMASISSPRAGGRRSVSFGAASPTSPSLSFLQSPQTATIKTTPTSTPTSTQGFQAALGNALIAASHSESSKGTHSDLLQILNHDRLPMGFSYHAYPHSVRVWYGDRDEKIAEHAVRWMENAMGPDKCQVKVVKGAEHALMYKSSVVIEVLEHFTQYWRDCELPCCSISRQYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDP8</accession>
    <name>A0A4Q9QDP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_866278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDP8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="282" mass="31893" checksum="756A1F6C3AB7ADDD" modified="2019-07-31" version="1">MAETIMPAAACQVTRFVNKTTGMRPCIPDMNSSGCGRRYKRDGSGSQVTLQLLTFRPNLFTRRMPADPHVVHRAPDQGPPITIYAKWRATDTLPRKDRSHPIAKNTVAHLYDVPICPDEPLRVGLYVKLRALSPQAYRPPYLPMETPRFDTYDPHIEGSIVGVSLVQEHTAEFVVRNECWWNPVAYAYIAVQYLPGLTAKLQLWEADCHWLLHTRLRSTCAAPLLSDAEITSFPGEDIGHYPAQFEYPDPVSDATPWLHVWSLERSRTRSTASVLRPATWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE77</accession>
    <name>A0A4Q9QE77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_805972</name>
        <name evidence="2" type="ORF">BD311DRAFT_773383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE77"/>
    <dbReference type="OMA" id="PIYNFPL"/>
    <dbReference type="OrthoDB" id="2500246at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU35244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13590" checksum="37587B99CFCA4863" modified="2019-07-31" version="1">MADFIQALDPSKLAIVGTAMSFVTSAFVAPVYNLPIFLFGVLSQESSEAIQSLRAFTFLLGGSILYDIIWMSNNSQHWFVRLLTVLLLILKLPTIFAFATALRQRGGSFSGLNIRGNDLSGATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEC0</accession>
    <name>A0A4Q9QEC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEC0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7827" checksum="C953CD68C61859D1" modified="2019-07-31" version="1">MLNLTPLRVLAGFPDSTPLGRHPSPPWQVPRSVPEGHWFHPLAYGWPRRCQWAVGKNSSWPLQASSLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEF9</accession>
    <name>A0A4Q9QEF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_43835</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEF9"/>
    <dbReference type="OMA" id="GCWFNRV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF5">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU66139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="514" mass="59211" checksum="77AD5F4C5D4A94E0" modified="2019-07-31" version="1">MASFLALDNYSTVLAFNVVLLLIVAGWHIRKRHRNAHLPPSPPSDPIIGHYRIFPRSYQAEAFFEWSKKYGDIFYLEILGRKIVVVNNYEMANELMDKRSANYSDRPVFPLFMNLGWGVSVTFLKYGPQFFKQRRILQQYLAKSEVARFRPIHTEEARKMLKHLVERPTDFDWMVRRFGAAVIMKIAYGHQIERDDDEYIKLTENVSLAHVDAGDPGTAPVDFFPILQYLPWWFPGCWFNRVVHNWSWAIKKFHNYPFEQVQRQMAEGHAPPSFLLTYLEDFSKPDYKGEHSLDDLKHATGAIYAGGAETTYSTINTFILAMVLHPHVLRKAQEEIDRVVGPNRLPDFDDRESLPYIEAIFAEVLRWRPVVPLGIPHSTLQDDTYNGMFIPKGTMVFANAWSMAMDTRVYHDPEVFKPERFLPGPHGPPEQFPHASFGFGRRICPGRFLAMGSVWMAIASLSATMDIRKAKGPDGIEITPKGEYTSGLSSFPKPFPADIRPRSEQARRLIYSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-06-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFK6</accession>
    <name>A0A4Q9QFK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_912739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU66086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13155" checksum="8A8FB077BAABCA87" modified="2019-07-31" version="1">MSGSGRKLRACRSCSQRKVKCLPSEGDPRCRECVKRSKHCERPEITATHNPCDNCKRSHVACEWSGAGPCTFCSSARSAASCSLASENSGGSDRTPSFALDPMRPSSSPQTHYFDIVLNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K236</accession>
    <name>A0A4V2K236_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_913742</name>
        <name evidence="8" type="ORF">BD311DRAFT_745634</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K236"/>
    <dbReference type="STRING" id="114155.A0A4V2K236"/>
    <dbReference type="OMA" id="YNEDWMR"/>
    <dbReference type="OrthoDB" id="5332616at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2190:FF:000001">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000002">
        <property type="entry name" value="D-2-hydroxyglutarate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.43.10:FF:000011">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000053">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051264">
        <property type="entry name" value="FAD-oxidored/transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43716:SF1">
        <property type="entry name" value="D-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="74"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU35133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="509" mass="55361" checksum="C5299BA4F3CFADA3" modified="2019-07-31" version="1">MLFSRQLARRPLIRAPRRWTHSPAALAGLKSVTEDDLVHFAHFLPPTSIVSTLSPSAAPSSELESFNNDWMNKYHGRSTTVLKPRTTEEVSKIVKWCNERRIGIVPQGGNTGLVGGSVPIRDELILSLSNMSKIRSFDDVSGILVADAGCVLQSLTDYLAPHNHIVPLDLGAKGSCQIGGNVSTNAGGLRLLRYGSLHGSVLGLEVVLPDGTILDQLTTLRKDNTGYDLKQLFIGAEGTLGIVTGVSILAAPAPQASNNVMLALPKFENVLPLYKETKRQLSEILSAFEFMDRTVYDLAVKHGQGRALNPEDVEGAECFVLVETSGGKREHDEQKLNSLLESLMEADVPLINTGVIATSPAQFSSLWAIREGLTEAVSKEGKAYKYDISVPLYKFQEVVDKTKNHLQEKGLLHEDAVKYVVGYGHVGDGNLHLNVVAAAYTPEIEAALEPFVYELVASYKGSISAEHGIGAMKTHALKYSKNETSIEWMKKIKALFDPNGIMNPGKVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K2D2</accession>
    <name>A0A4V2K2D2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_983046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145464">
        <property type="protein sequence ID" value="TBU50996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K2D2"/>
    <dbReference type="STRING" id="114155.A0A4V2K2D2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="494" mass="54363" checksum="71681812867561B6" modified="2019-07-31" version="1" fragment="single">MGSGTVKKKLKRVTDVLTSKRVQKPATAAPSTPTKKDTRGWQWHTPRRPQGRADCGHSQPLPALIGFLAAALSPRPKASAPATSRSQPASSPGHPPLSEVAPCCDFVAPSVPLAASVPTPSDHTPTETTTLDTSPDHQPTVQDGDADSIDSRLDDDDVDDQDGVHGNYHHPSTRCHKFLDFGYAILARDLLDERETPPLGDACPVCHATVASKAQNRRTLYYCEDCFTPVRKCIDCILTSHREHPFHRIHSWVAEKGCWLRVKLGDIGYQMALHHGGYRCPSATSEGRDIVVVHEHGIESVPVVYCACMDAPPDPSQLMEAGLWPATWEKPRSAITLAALKTFHSLSHNAHTNAHDFVAHLERLSDGVITVDVKDRVREFRIAIRTYGFVRACRRAGVDPCSDLPIGCLAVTCPACPQPGHNMRPGWEGRDEEFAHMDALHFCIDGNFHFNLKPKHTDPKDFPLTKGAAYFAHEDDFKAYIATTKPYPNEPSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5Y6</accession>
    <name>A0A4V2K5Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_46625</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5Y6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="582"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="537"/>
            <end position="538"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="583"/>
            <end position="584"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU66194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="605" mass="64984" checksum="4E272994EDD8578E" modified="2019-07-31" version="1">MRKNLAIFAFALAANLELTSAALFTNPADVPTNKQYQYVVVGAGPGGSVVASRLSEDPHTNVLLLEAGPSDEGVLQIEVPYLALELQPNTTYDWNYTTVPQTGLGGRAIAYTRGHVLGGSSSINIMAWTRSSLDDFNRYAAVSGDDGWSWDAIEPYFKKIEHFVPPVDHHNTSGQIDIQIHGTRGPLNITVNNTPYPMDSHVINTTQELGDEYPFNIDMNSGHPLGIGWAQSATGNGMRSSASSSYIRPVLSRPNLDVLVNTVATKLLRSGHDNVTGVPVFSGVEVAQSSTSPVFAFNATKEVILSAGAVNTPQLLMLSGIGPSSHLSSLGIETVVDHPSVGQNLSDHPGVGNQYSVAAAQDDTDDNLVRNSTLFNELLQEWKDKRLGTMTGNGFNHIGWLRLPTDDPIWKTAQDPSAGPTAAQYEFLFDDGYVAATAPPTGYFITVDTVLVSPTSRGSITLASANPFDSPLIDPAFLNTTLDIYVMRAAIRSAAHFLSAKTWDGFVTGQGGDFANVDLDLDESVDAWARARAMTVWHPTGTAQMGKCNDTGSVVDPDLRVKGTKGLRVVDASVFPYIPASHPQAVVYAFAERAADLIKDGRRYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K699</accession>
    <name>A0A4V2K699_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sure-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_1005581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145315">
        <property type="protein sequence ID" value="TBU51493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K699"/>
    <dbReference type="STRING" id="114155.A0A4V2K699"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008252">
        <property type="term" value="F:nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="5'-NUCLEOTIDASE SURE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457:SF0">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G01070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020930233" evidence="4">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU51493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="319" mass="32831" checksum="C1B4BCA1138CB0F2" modified="2019-07-31" version="1">MKHWTSLVSTISIALLIRGASAQNIILTNDDGWAVAQIRAQLDALVDADFNVVLSAPAENKSGTGSSTATPQPLSQPCEFNTCATGSPAEGFNASDPTLNYVNSFPVDAVRFGIQTLAPEFFGSAPEFVVSGPNVGTVLDNLGTVTQNSGTVGAACEAAKEGIPSAAFSAATDAQISFTTLASSPNSPDTLSALLYAELTANFTRTLLGPAARPILPSGVALNVNYAATTFSSSGPPNGDCATASDFQWVFTRLLPNSTAVDVETCGSENLPDETTVADSGCFATVTVMNATTKSDVDADVQAQVLDRLTPSGLLTCFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6J5</accession>
    <name>A0A4V2K6J5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_981859</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6J5"/>
    <dbReference type="STRING" id="114155.A0A4V2K6J5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU52453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="538" mass="57034" checksum="6B0F38C4684A3C89" modified="2019-07-31" version="1">MPVHQDPLPMTDTSPAGNEKPTKSDAVPTISLRNDDHNAHAKRSMSKDIILICTVTFAAILNTANSTAVSLSLPTIGRDLNIAESNLQWIISAYSLSSGCLLLFLGRLADIFGRKLPFIIGCAWMGVLGLGCGFAQGEITLDILRGLQGLGPAAATPAAIGILAHTFPPSPRRSIAFATFAAGAPVGGVVGNIIGGVLTQFTAQSWRSTFWFMTGLSALCCLGGLFSIDADDPYALPDKRIDWLWAFLVTTGLISIVFVLSDGTTAPDGWKTGYIIALLVVGVFFLGGEISQTWWTPPPLMLVSIWGRANGRLAAMLAIAFSEWCSFNSFLFWVQLYYQDYLGLKPILTMVRLLPMSAAGVTCNVIVALVVGRVPIVYLVVIGMLFTGAANLLFAVIVPSAPYWAFGFPAAIISVAGADFVFVTGTLFITRVCLPHELSVGGAIFQTITQLGTASESLGVALNKGGTNAPKPAQLTAYKDAMWSGFAFALFGVLLAGFFLRGVGIVGHRKADSDSKGEKATHVSEKPDIEAINESGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K839</accession>
    <name>A0A4V2K839_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_478614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K839"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118:SF12">
        <property type="entry name" value="CYCLASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="24568" checksum="D7C0847672B8D448" modified="2019-07-31" version="1">MAAVYVDLSHTLEPNVQIYPGDPAFACCPVQTIAKDGNSVHSISMGSHTGTHVDAPNHFCQNGAPIDQLPLSTFIGNAVVVDVTQKSAKGKISWADLAAYEVIIRHKVDLDHGAFVLLHTGWSKHWKSQMYYDHPFLEAEAARRLLELGVKVIGVDTLSPDETRVDGSIPDFAVHDLVLGAGAVIAENLTDLEAIQKGDWLVSLVPLKLGGLDGSPVRAFAWSTAALSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K854</accession>
    <name>A0A4V2K854_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin NUP188</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_1039040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Nup188 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V2K854"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018864">
        <property type="entry name" value="Nucleoporin_Nup188_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044840">
        <property type="entry name" value="Nup188"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048883">
        <property type="entry name" value="Nup188_N-subdom_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31431">
        <property type="entry name" value="NUCLEOPORIN NUP188 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10487">
        <property type="entry name" value="Nup188_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21093">
        <property type="entry name" value="Nup188_N-subdom_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal" evidence="10">
        <location>
            <begin position="38"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup188 N-terminal subdomain III" evidence="11">
        <location>
            <begin position="685"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2025" mass="223684" checksum="EA6720A199E76A03" modified="2019-07-31" version="1">MSADSSKRSNLIDVTYQSLHHHLSGHLEGTTLDQLGDILKPRVEQLKNVAELFGKPSDASKKKVDSGSVTLPDGVVLRVEDADKDFIHALSKKFDIDQVQALILLRSFFYNEGLPADIGGSDSSSMVEELVNAITPFYYSERLHVLRTLIPLFRALQSQGTPIFEIAETYIPKIVSDATQFAQSLLEEYSRKTYAEVPEGAQEDPRQASAWAKQNAKEQLVMLEVLFWTMWGHAACSGPLVAKIYETAYQTHLGSQQQNSTLLLDEESVQVLQDCAVMWILITVEVLELERASETGAIEMSANPTDKDIYWSSPEHLKRIHQTVISQGNSNFVCVYMAWTVQLGRFAKVAHESRELPTSYGSFFQTVISSTQSRDAGQAVDRMKDIGLSSDAGLFRLLHTLLTSSPVFVTSAAWRTGSSVTDPNTVAYRSVMKGLLISVVELVPVEMIADFDGFLEVWIALFGRSEPQSVVGICCQFWQVDWHADTFRRAIVDVARSRCPIQVRPLLRLLRSLTGTGFLDTDPLSTVDHIEADELLTADRNLCTRAVFRYFNELPTFTQVVHISQCTGAHALYEKLPERYGSSSATPGPSYMNLRPIRLPGGSNLPAKSVGKLLSNDGGDLIVVAWQHRHSGWKLVLEFLTDYVNRRRTHSSSGGSYQDVSFGARNPNQPLALKLEDIGVEMDHNGDEDIVIDCLDLIRSVVQDSPDLAQELLLSMESGDSVVSHTMAEAQAPDLVQLTTMILEESLSRSVGQHHVAPRTQLITSAMSVLTALLAVPSHSNRVWLYIRSTASLFGTDRASGVASSVLASERLTGHYTMTLALLRFVDALFTEASSTVLLVTRQNPKLQQIKEEVLMRATRFVHSEIWVEHMGWKYAQLGDRFEIGRRVTTLYMQIFNHASPALKDMPFAKLSNAVADALLFKATTSTITPLVASLVAGGSIFNALYNSRRHGDARRLVYLLESHLSLTRILLTYKQKSSASTKVCLLEQALCSRAGHNSSFEGSSLKSSPIDALAAYVKERGMGPIVPVTATQVLFALCSSLSAAETSTSTIIGHLSDPEATVSIMVRIIQHPYDDALLRGAVWNFITLAVDKEPALARLFVTGQLRMPNAKGKEKAEDSGGPLKVSALNVACDMLEEWKELWEPNPKLLASLLRFLDVVWQHAHEHKAVLDPIRKDSKFFDHLGGIIAEELGPAPDCATESYVVTDGVAHSDHHEAISGYSYRSAAKSHAAHILAADIRMHVQSQGSKDKPPSYNAISSTLRSEDQINELIPEAAASSYRPELHDESADLLKNHYPTLSLDHLQAQEPIVEREYGDDFAFSTSLARFRLQIYAADDEVQMEEAIRNLHTINLNLSLAHVQTALAEAWHFLLLQVIPYLRGDATVRPHLLCLADSLSRDLAAEQRSGEMMSTIHTARLSLVLSLLEVAWFSTSDKKQEVETFIALAKNVRGIILNPAQSPAKSVLGQVPVPFHRPLLQILYFCARHARSISRRSKVLNAEQRLAIAALLDATLVFVIDAVRITFDRARLTLDLDIDLDMELLVAVFEQSTRPDLNPSPSLWLTRCQETDVVQASLQLFSRMDVVGLSDVALLRARKQPLYTPHVLTFHMAMASITPAAERLASEGLLVAYLENTISRAIREGKVDVTIPELPGEQSPAHHTYCSMLAIVAGVTTALGKHGQYFESEVCGLLQFYNEQIHRALSWTIDDPLTLPLLEEIEQVVNVYAAIARGSAASSNDAVKRVLQSFTADALLLMQQLNYALTHPNHLASVFEPITSEERTRFEQDRASSSVKTPSEAVDPMRRPFLARLIHRLYRLSSTVLSALIDISGAETVLLGEPEDWQVSQALIVPHSKVVLGEPASLGTLLELGNASLDILRLLVDRPPTQALTPATSNDKALDVRDTVAVVRRNLEAALLYAVTQLAMWLSKPEFDAPSNDADGDDMVVEGQLGDSTSLKERRARKASMTMAERLRRGMKGEMAADLQALLNKVKPVIAKSTTVLGMKDVDLTQALLYFVQERISVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K883</accession>
    <name>A0A4V2K883_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_925944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K883"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="231" mass="25353" checksum="CD96E5695E9809C2" modified="2019-07-31" version="1">MKAGRATRPPRPRSSTVSYAPVRRTRMPRRRSEEEAEAQYRGEKKLGEPGLLDAWLAARLSQMPTTQTQLRGAERTGEDGYEDEGGGGKGRWGDEVHCTVQVQCIKAPNDPDSIFSDPDTFVLHLITSSPLSSTRRPIQTTTGAERRLGGTDGSDRWRRIELGTYAGHPESLDAPPWTRLLPAGQVVEFRESAAGLAELLARAAPWNCEDAMTPLLQSLGAVSLKDDWESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8M2</accession>
    <name>A0A4V2K8M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_321901</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU60548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="353" mass="37616" checksum="903E716461C97466" modified="2019-07-31" version="1">METGPKAIPNLATSRPPAAVQVLPFDASTSHARLCAQCFRLLPAKTSSRKCEPCRGKDPDTLSRWKKERARERAAQASMEGTFTVELASGSKTEAAAVRPSRSSADTDVEMANATRGTGAPSTGATKRKADAVDAESEPSRGAGHLAHKEYQTSQELMDALSRDVEAFRASQAAAPSRPPYVDFRGSFTIVMDPDVRGRPRVKQVVEALAQSAKLRFGKLVKCESDVSCGGHARTYWCCCSPALECPKRSAPPAHLGQPTTLAAGPQSSPLPSQTRTPPKRTQSTLIGWLGKPTPKEEVTDAANAPPPGCGGTITVYAVTDFSHPLGRMGIRGQKVSVHVEHPGRDLDQVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K960</accession>
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                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
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            <end position="37"/>
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        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
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    </evidence>
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            <dbReference type="EMBL" id="TBU62688.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="254" mass="28622" checksum="98679DC01550DC0B" modified="2019-07-31" version="1">MAPSRRLRLLVPSLFEFPKHLELFPNLLTSLGSDDECATSTSRAQQILSAASITAAEDIPFRQERPRPAQGGERISEGFLMRLGRSECLWRFRFAADELIELAAALRLPPIFRTPASGYAVPRLEAITLTCARLARPGDIYDLVKEYDRSAAAISEIVNHTICLIDVAWAHLLDFDHNHLLAPQRLSEYASAIRNAGAPMSTVWGFIDCTLRRISRPTWFQRAAYSGYKKYHALKYQAVMIPNVRKVCSTSRCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9R0</accession>
    <name>A0A4V2K9R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10965" checksum="2A944C6F68ECF685" modified="2019-07-31" version="1">MNLCFLASRPSWHIIACIVTVRSASQRIVLHPCILRNLHYYHAGFDYMLLRISIHFENPLDIAYHNASQGTARWFARMPGKHTIAYPRVGYIIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Y0</accession>
    <name>A0A4V2K9Y0_9APHY</name>
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        <submittedName>
            <fullName evidence="6">Utp21-domain-containing protein</fullName>
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    </protein>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4V2K9Y0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
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        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="5">
        <location>
            <begin position="68"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="309"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="615"/>
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        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="4">
        <location>
            <begin position="745"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="803"/>
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        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="906"/>
            <end position="934"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="949" mass="104343" checksum="5693B51DE86A527A" modified="2019-07-31" version="1">MGAKKETRSSPPPRKRARVEAPHSPNFKQGPRLFAPFRALGLITNNVPFVLQTRSHKGATDGPRIHLLTCLGRAWALWEGGKMGLLFVGPDAPGPIASMAMDGNAVWVSSGLYVMKYIRGKEVARLTNPLETSLTHILVFGPQLLALTDDGNRMLVWDTESEELQTTIQFEPGFTAIMIHHPATYLNKVLVASSEGSMQLWNIRTQTLIHTFPAACLLTSPSKTTSTAITALARSPAIDVIGIGFSSGEISVYDIRADERLMRMVMQDGGIRAMSFRSDSQPILATASSTGHIALWDLNSGGRLLHIVRGAHDGAVTALEWVPGQPVLISSGEDNSVKQWLFDSPTEAPRLLKFRSGHHAPPHLIRYYGEDGKQLLTASRDRSLRCTSVVRDSRSFELSQGSLAKKATNLSIPIASLKFPAVTTLSYSATRAKDWDDILTAHTDEAVARTWTMKDKRVGKHVLNVTAEKKKGGTVGSVKAVCVTACGNFGITASSTGIINMYNMQSGILRRTFDIGPCPATVPSRFRPAAGKKKEERCVTGLASDALDRTLVASTLDGTINFFDFHTAALEHTLVLLSAAVSITLHRDSGLLAVICDDLVVRVVDIETRRVVREFGGFRGRVLDVTFSPDSRWLVTTSLDSIIRTFDMPTGRLIDAFRTSSVATSISFSPTNDFLATAHVDSVGVYLWANRAQYSEVPFQSIVEEDVTDVSLPSMQGLAEDEALDALSALTVEDKPADVFTTPPQLDGELVTFTLLPRSRWQTLLNLEVIQQRNKPKEPPKQPEKAPFFLPTLPGVEQRFAVDQPKAQQETKKPTKRLQRAAGETESVFHKKLAEAHESHSSAYEEFFNYAKALSPAAMDLELRSLVSLDSLRMFIGALTSRLHSHRDFEAVQTFMNVFLRMHGEVLTANEELRNELETLAETQRKESERLLELLASSLGTLGFVRDTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2KA21</accession>
    <name>A0A4V2KA21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Glutamate decarboxylase</fullName>
            <ecNumber evidence="3 9">4.1.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_943530</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate + H(+) = 4-aminobutanoate + CO2</text>
            <dbReference type="Rhea" id="RHEA:17785"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:59888"/>
            <dbReference type="EC" id="4.1.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.15" evidence="3 9"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2KA21"/>
    <dbReference type="SMR" id="A0A4V2KA21"/>
    <dbReference type="STRING" id="114155.A0A4V2KA21"/>
    <dbReference type="OMA" id="KNIMQNC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004351">
        <property type="term" value="F:glutamate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006538">
        <property type="term" value="P:L-glutamate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000017">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.50:FF:000001">
        <property type="entry name" value="Glutamate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010107">
        <property type="entry name" value="Glutamate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01788">
        <property type="entry name" value="Glu-decarb-GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43321:SF3">
        <property type="entry name" value="GLUTAMATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU66058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="539" mass="59800" checksum="F79F73302DE8737A" modified="2019-07-31" version="1">MALSKHLNADRLIQASKDHKAPGAHSSTDHHAVHGYGARYGTEPIPKYRLPSKGTDAEATYQLLHDELTLDGNPALNLASFVHTWMPKQADQLMMENISKNLIDQDEYPMTQVIHTRCVSILADLWHAPSTQQAIGTATTGSSEAIQLGGLAMKRLWQEKRKAAGKSIHEPGPNIVMGANAQVALEKFARYFDVEMRLVPISEESHYRLDPKRAMQYVDENTIGVYVILGSTYTGHYEPVKEMADLLDEYEARTGNSVPIHVDAASGGFIAPFATPKLEWDFKIPRVVSINTSGHKFGLSYVGVGWVVWRSKQFLPKDLIFELHYLGSVEYSFSLNFSRPAHPIIAQYFNFVHLGFEGYRNVALQDLANARLLSRALEKSGLFYVLSDIHRPQTVGALASAAQKTVGINEANVENYSPGLPVVSFRFTDEFRQQNPDIQQKWVQVLLRAKGWIVPNYELAPDLESVEILRVVVRENLSAVMIDRLVADIIEIVEGLVKSDTPTHALSKMSSGVTTAEHHHGGLDKGSGSKSSGTYAKQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2016-03-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A0U3CB12</accession>
    <name>A0A0U3CB12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucanase</fullName>
            <ecNumber evidence="12">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cel6a</name>
        <name evidence="16" type="ORF">BD310DRAFT_803735</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15" key="1">
        <citation type="journal article" date="2015" name="PLoS ONE" volume="10" first="E0145166" last="E0145166">
            <title>Saccharification of Lignocelluloses by Carbohydrate Active Enzymes of the White Rot Fungus Dichomitus squalens.</title>
            <authorList>
                <person name="Rytioja J."/>
                <person name="Hilden K."/>
                <person name="Makinen S."/>
                <person name="Vehmaanpera J."/>
                <person name="Hatakka A."/>
                <person name="Makela M.R."/>
            </authorList>
            <dbReference type="PubMed" id="26660105"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="15">FBCC312</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase family 6.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="12"/>
    <dbReference type="EMBL" id="KT595235">
        <property type="protein sequence ID" value="ALT57232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A0U3CB12"/>
    <dbReference type="STRING" id="114155.A0A0U3CB12"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.40:FF:000001">
        <property type="entry name" value="Glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.40">
        <property type="entry name" value="1, 4-beta cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016288">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036434">
        <property type="entry name" value="Beta_cellobiohydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001524">
        <property type="entry name" value="Glyco_hydro_6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34876:SF4">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01341">
        <property type="entry name" value="Glyco_hydro_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001100">
        <property type="entry name" value="Beta_cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00733">
        <property type="entry name" value="GLHYDRLASE6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51989">
        <property type="entry name" value="Glycosyl hydrolases family 6, cellulases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00655">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00656">
        <property type="entry name" value="GLYCOSYL_HYDROL_F6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 12" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041001691" description="Glucanase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="20"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8 11">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="399"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001100-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ALT57232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU65511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="450" mass="47375" checksum="30A924D8229CBC90" modified="2016-03-16" version="1">MSKFATLCALLTVLPAVSYAQSPVWGQCGGIGWTGATTCASGSVCTELNDYYSQCIPGSSAPGTTSAPSSTVSSTTRPTSTSSGGSAPSTTPAAGNPFVGYTPYLSPYYAAEVQAAAANITDATLADKAASVANIPTFTWLDQVAKVPDLGTYLADASSIQNSTGQKQLVQIVVYDLPDRDCAAKASNGEFSIADNGEQNYYDYIDQIVAQIKQYPDVRVVAVIEPDSLANLVTNLNVQKCANAESTYKACVTYALQQLSSVGVYQYMDAGHAGWLGWPANIQPAATLFTQMYQSANSSPFVRGLATNVANYNALTAASPDPITQGNPNYDESHYINALAPMLASAGFPAQFIVDQGRAGQQNLRQQWGDWCNIKGAGFGTRPTTDTGNSYIDAIVFVKPGGESDGTSNSSSPRYDSTCSLSDATQPAPEAGTWFQTYFETLVSQANPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MHR9</accession>
    <name>A0A4Q9MHR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930804</name>
        <name evidence="1" type="ORF">BD311DRAFT_764586</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143461">
        <property type="protein sequence ID" value="TBU25456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MHR9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU25456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5806" checksum="F0958AFEFA8227B6" modified="2019-07-31" version="1">MHSAARSRESFSSSSPCFLGSTSCGGRLALWSSRRMACGGGLYVRCIGTSVVRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MRQ5</accession>
    <name>A0A4Q9MRQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_922581</name>
        <name evidence="13" type="ORF">BD311DRAFT_863988</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MRQ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9MRQ5"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17961">
        <property type="entry name" value="DEADc_DDX56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="44"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="346"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="591"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="333"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="384"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU30469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU60486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="651" mass="71581" checksum="85B12438D838D1C7" modified="2019-07-31" version="1">MPDARLVDPKATFASFSHILDARILRALADMGFSRPTLVQSKGIPLALENRDILARARTGSGKTAAYCIPVVQKVLNAKSSISEEDSRRQATRALILVPTRELAEQVSAHLKSLLTYCDADVAVANASTGTTAHLQKTLLSDNPDIVIATPSRALALLQSKDLSLGSLESLVIDEADLILSYGHDEDVRQIFGGGYLPKVFQSFLMSATMTEDVEALKGLALRSPVILKLEDEEDEAANLTQYSVRCSEVDKFLLTYVILKLKLIKGKCILFVNDVDRCYRLKLFLEQFSIKSCVLNSELPLNSRYHVVQEFNKGVYDYIIASDENSGKAEQDSNDEQEDEAEEADDDDFMSSQREPEANGAPSEDDADSTPAQSLKRKKRANSPAPESSSSSKPKSSKRKRRKGGGAPDAEYGVSRGVDFVDVSCVINFDLPASSRAYTHRVGRTARAGRTGMALSFVVPKELWGKNRVVGCVESAKRDEEVFARVEREQAARGSQIKEYQFDMKQVEAFRYRMEDALRAVTRSAIKEARIKELKTEILNSDKLKAHFEDNPLDLEYLRHDKPLHPTRVQSHMKHVPKYLLPRIAPVPGADAGVESDSKPAPGPGDVGFVPFNKNARGRGRGRGRGRGGRGGGGPGRGGKKKSDPLKKFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N5F8</accession>
    <name>A0A4Q9N5F8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_866676</name>
        <name evidence="18" type="ORF">BD311DRAFT_709543</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
            <strain evidence="18">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N5F8"/>
    <dbReference type="STRING" id="114155.A0A4Q9N5F8"/>
    <dbReference type="OMA" id="MIDPPKQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="218"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="424"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="41"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="647"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="570"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="187"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="74"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="649"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="738"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU35228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU65055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="773" mass="85680" checksum="5066A30C71C74E4C" modified="2019-07-31" version="1">MSKTQTAEEVVELNPDFSFDLSGDPYNDFLNDHIDVQDLVKKGSKPEPISVDDIIARRKLRGNSARKRKRPVEDEGEEEDSEGDEDSDDHEDDEDSDGSAVSEEEYEGVSADEDEDDPLATSGEESGVEEDEENGKGDEAHDMSDDAEDEEDAASSSGDESEEETQAEKERKAAFFDSESGPSEAHTSFLSMNLSRPIIKSLTTLGFTTPTPIQAATIPVALLGKDVVGNAVTGSGKTAAFIIPMLERLMYRDRGKKAAATRCLVLVPTRELGVQCFEVGTKLAAHTDIRFALVVGGLSIKAQEANLRTRPDVVIATPGRLIDHIRNSPTFTLDALDILVLDEADRMLEDGFADELTEIIKSCPTSRQTMLFSATMTDSVDELVRMSLNKPVRLFVDPKRATARGLLQEFVRVRAGKEAERSALLVALCKRTFKSRVIIFFRSKKLAHQMRIVFRLLDMKCDELHGDLSQEQRLKALQQFRDGHVDYLMATDLASRGLDIKGIETVINYDMPGQLAQYLHRVGRTARAGKKGRSVTLVGEADRKMLKAAIKHSSGGEDQIRHRQVPQEVVSKWAQKLDSLKQEISEILQEEKEEKQLRQAEMELKKGQNMIEHEAEIFSRPARTWFQTGKEKAKAEALSKQQYEAGFDAGKKGKSKEPAQTKPKRDKFAGLSRRAKRRKMAMEEDAAETGAIRAAVRSAKKATRPAKIGEPERRTTSSKKRDKKGVRSKSKTKSKGGAFDKDLGQRPAREGVRAKKGDVIGGMGKKKGGKRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NC22</accession>
    <name>A0A4Q9NC22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_924823</name>
        <name evidence="10" type="ORF">BD311DRAFT_769904</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143530">
        <property type="protein sequence ID" value="TBU22704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NC22"/>
    <dbReference type="STRING" id="114155.A0A4Q9NC22"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU22704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU59503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10998" checksum="2E1CD1D01782BD18" modified="2019-07-31" version="1">MTKGTTSFGKRHTKSHTLCRRCGNRAFHKQHKECAQCGYPSAKLRSYEWGQKAKRRKTTGTGRMRYLKTVSRRFKNGFRENTRAVKRTKKTTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEL9</accession>
    <name>A0A4Q9NEL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_876915</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEL9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NEL9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000464">
        <property type="entry name" value="Ribosome assembly protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="530" mass="57621" checksum="A23FD191975E5B4F" modified="2019-07-31" version="1">MATLLPPPKRQKVYHGVPEPEKEAPKPAPHVVVQFVNEEDGEPLAPAVNLPANVSKEGLEAIVNKLNTKDEDPVPFAFHVSLPADDQTAGAPTRITISKSIQEDVLSHPSHAFTPEDVFIIHCSPQAVFKVRPATRCSSTLSGHTSPILCASFSPTGNLLATGSGDCNARLWDLFTETPSHVLSGHKGWVLCVEWEAMERKLATGGHDGHVRLWDPKTGKPIGDALKGHTKWVTSLSWEPIHLNPSAPRLASSSKDGTVRVWSTLVRQCEYALGGHTASVNVVRWGGGGLNGKGVLYTASSDRTVRIWDANGGKCLHILKDHAHWVTTLTLNTDFVLRTGPFDHLGKKTSSDSEAQSLALARYNNLVSTTGELLISGSDDHTLFLWSLFPSRTTSAEASAAAAERGGKLKPLARLTGHQRQVSHVAFSPDGRWAASAAWDNSVRVWDGRTGKFVATLRGHIAAVYRLAWSADSRLLVSASKDSTLKIWDLKTYKIKNDLPGHTDEVYCVDFVADKLVSGGRDRTVKIWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEQ9</accession>
    <name>A0A4Q9NEQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_937311</name>
        <name evidence="11" type="ORF">BD311DRAFT_755001</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143407">
        <property type="protein sequence ID" value="TBU30230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEQ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NEQ9"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022357">
        <property type="entry name" value="MIP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF14">
        <property type="entry name" value="AQUAPORIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00221">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU30230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU53756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="341" mass="36719" checksum="C6204D5F5CAC2628" modified="2019-07-31" version="1">MAVAGMHVLRRRDVIHLADIQPRSNAHVAWERIRHRQAHWFVELVAEFMGVFFYTFAGVGSTVVFLVGNVAGENGLSSMFQIGCAYSLGILLALVVCAPTSGGHFNPAVTLSFVLFRGFPPLKALRYIVAQILGAYIACLLVYVQYGDFIHEVTEALRAAGKLDAVLFTPNGPAGAFALYVSPGSNLGRVFLNEFVVDFLIGLVIWACLDPTNFSASPTTAPLIIAFTYGVMVWGYATEGIATNAARDVGARLMALTIWGLDAGGGRYAAIAALTNIPATILAGYFYTFILGDSSRVVTPAHVDYLGGHLAHEEHSQGVVARESSNPSYNEKSNEEAIERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKD1</accession>
    <name>A0A4Q9NKD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_938448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKD1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NKD1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="585" mass="65773" checksum="66F0083560BE6F74" modified="2019-07-31" version="1">MPPDPRDIFSPDPIDLFHVPDSAPQTPRSANPVSEEDSSPVVRPPGRRRRVPRNPVDSDVSEQEEGGRQLGLRLAPRVGSVEDEDEDEDEEDEVDEDAYNEDEYEEDDDDDDNDDDDDDDDDDDDDDDEDLPQFRGSTHNNTESPSTDALSTPPSFHELALEVQSSPDNPVPPVSAQHSPSPAAVPQLPCTPPAMSHSPGESTILVPIRNHEFPSLLRAAERKLGSQIASALTNPLDEALNSATFQTLLETFLFPRLRSRDSENGGFKLDQYSQLQAVAWHWEKDDKRKRKRSSSRQRGRADLDADVSKYIEAIKDRRVPDMTTVVMFEEEVPVPGGHAYQVVTHRGPKLCITEIKSFAWSASSGDREMTLSGVLTKAHQQNFIAGQYLFREDESLEHIASFVGAGPAWSYSEFHRNQYPLLDSPPLPNTHAEYLRWEERVAEETPEKPKKKKRKTRRSSAHARLASSRARKPDLVSSAEEGTHASGSGVPPNRFLEEAPQMPPKDSPALQAIFRSAGHYSRQRSAFLYVLDRDGRTYEAFDVIVKRIRKWYTHSNAHYKLDFDKDPYEEGSCPASRGRALTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNH4</accession>
    <name>A0A4Q9NNH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi CORVET complex core vacuolar protein 8-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_806847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9NNH4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="1">
        <location>
            <begin position="500"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1284" mass="142775" checksum="D23199BF0E2F4CC5" modified="2019-07-31" version="1">MVEKNVGAVTALALSFDHTYIAAGHATGHIQLYDLRSPKVPARVVPPTTLAAVASGRQEGHLVGSRIVSIGFIAGRHTALVSADDSGLAFYHSLGKVLFVDATDILRILGKYPDEDVPDAPATLGHRFRRRRSRKPATILSMAPLPLGTASHPTDAYNLIALLTPIKLVIVGLKPSPKTWYRRHRESEDEVSAKSRFKGCLAWFPSVSLGADLASAPERNNKKSQANGVHPTSTPTLVYSWGEHLHLLRVSESKVIQTVKDPKSGKINKVEVGRIVFEEAGSWMASDDILALQWLNVNQIIVLTHAGFEIYDVRTCKLVEREPYDAWSLVSPVLSHTTNGAITYSDAVSEVAHSVRVYKGKIFLLGQHGVQVGTLLTWADRILHFVEEGDFLSAIDLTRSYYVGDAPGNRNGLPDDPEKLRAVVGQKLRDLMVASARYAFSEERLTDGTHVTPDGRGVDRTELFEGLVSTCARACRALDDYEFFFEDLFQYYDNNGIAGIFLSQLEPFMLDGDIRHVPPWITQRLVALHAEANRPDLVERLIWHIDPECLDSNQAITLCQQYRLYDALIYVYTRALRDYVAPVVELLGLVRRVQQYRRQRAEGSPTSSGFLDEKALEPIILNAYKIYPFIADTLTGLTYPSEEPLPEDEAFEAKNAVYTFLFFGRSSVWPEGEGGKLVLTSDEENGVEPTYPYTRLLLRFDPEAFLHTLDLAFEDAYLNDDTRGVSRLVIVKILLEILASPNLSPEERTFVHIFIARNVPKYPQFIQIQPSALHNILIGLAEDPDTSTREDRQLAEEFLLSAYTPHESERILELFKQAGFYRILRSWYRQEKRWSELIATYLEDPDLPRSDVFTSIDDVLVVAKRSNKGKLSENLAETLQHSLPALLDVDISSTAALIDAHLPAVHEVALDDLGSDSDQERFIYLQHLLQPPQPHEEEHVFLPRKPSSRPPDLPLPLRLAFVSLHCRFEPSGIIAALRYLPKDYLDQSETIRICEEHEVFDAVIWLIDRGGDPRAALSKADSFDRRLSARIADALATNDDNSQDLISEALHKLESIAGTSISICLERSQVAASAELPLEDLWFQLLSSQIDCVQRVASCCSLEALAPSEGVPSDDPRVQREHGTISALRSLVHKTFSSLMSVSSTRAVSFPRLFKRLVSSASSSTGNVSKGTLYTEFRTILTGMLESFRSEGDMLVITKHLVDRDVADTIAELVGERTKGWAPARGACNSCGVAFVTKKPVDSQGQGEAAGPASEPVVVSRTGAIYHTRCLPLDFHANTTVNVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRK9</accession>
    <name>A0A4Q9NRK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2H2 type zinc-finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_1035041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the REI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRK9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NRK9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="110"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="312"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="323"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="488" mass="53768" checksum="E1A59BEDC80966EA" modified="2019-07-31" version="1">MTDILVAQPAPQGNLYTCISCTIAFHTAQDQREHYRSDHHRYNMKRRVAGLPPVSAALFNQKVLERRAETAVMASPKGSSCEICGKTYTTENAYRSHLISKKHKENELRAAAKAAAAPEASPVLEETYASPEAGPSSPPASSGAAAEPGVEKVTSQLQGVSLSVDEGASEEQINQTIDEKIAAARARLSPTQCLFCTSAPPAETLEDNLTHMSVAHSFFVPDAEYLVNLAGLVTYLGEKIAVGNTCLYCNTEFRSLEAVRKHMQDKGHCKIAYDTDVERLEVSDFYDFSTSYPDAEERNARKAARAARRAAKEKAKAEKQETEEWEDVEDDADDDGEVDEVVDLEASDESDEESDEDELDENQVTYGDSSYELVLPSGARIGHRSMRRYYAQSFPGMRRGGKPEDPNSGAALVRRLIADKKSALVPRKGGFGAFGSGTDVVKARNAGEAREAGRHVREYRDQRRREEFKTKVGFIANSQKHFNPPVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRZ4</accession>
    <name>A0A4Q9NRZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_935821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16558" checksum="3F21412F0B2E0D92" modified="2019-07-31" version="1">MDFQRPHIFAIVDTDQLISDVIISSLHTMSDFDPSASLTSLATTNTGGTATPTASTAHLLPAQSDGSSSVAPGSTASSSQPLASSTHLTTAPRSQTYPSSSNTPPKDYEKAFATLSSQWGWGGTVSAKNPKSEKGKKEKKDKKEKKDKKDKKKDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSS6</accession>
    <name>A0A4Q9NSS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_924208</name>
        <name evidence="4" type="ORF">BD311DRAFT_768448</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143505">
        <property type="protein sequence ID" value="TBU23423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSS6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NSS6"/>
    <dbReference type="OMA" id="RVFYFNR"/>
    <dbReference type="OrthoDB" id="9936937at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058841">
        <property type="entry name" value="HTH_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040554">
        <property type="entry name" value="KPWE_PEX14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36855:SF1">
        <property type="entry name" value="PEROXISOME MEMBRANE ANCHOR PROTEIN PEX14P N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25871">
        <property type="entry name" value="HTH_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17733">
        <property type="entry name" value="KPWE_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEX14-like helix-turn-helix" evidence="3">
        <location>
            <begin position="12"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxisomal membrane protein PEX14-like KPWE" evidence="2">
        <location>
            <begin position="107"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU23423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17607" checksum="BA567D5FCFD14967" modified="2019-07-31" version="1">MDSQNFPSPSIAALERFQSYPFADDADYQQGLAGIVSSGALEGKSEDEKAEIILGSEVFYFNRISDISITLDEARIARRDFQNQETNIASDSSTIPLRLPAGNQEQQTLTFAQLKELIEQGRTDEIPNNKIIPNVLSSDTPSESKANVRKKPWEIQATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NT58</accession>
    <name>A0A4Q9NT58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_109715</name>
        <name evidence="1" type="ORF">BD311DRAFT_658280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143403">
        <property type="protein sequence ID" value="TBU30841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NT58"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU30841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="14272" checksum="CCA804C628C57761" modified="2019-07-31" version="1">MLPHPPLYQRNQRQPAVRQLGFLTETFSKMPQYMCASPATLLKRAAARQWIPQRLFEPGDKVQTFDKTKGEWISGVIAVNHDPPSFCEEKGCWEYPVIMDRATRQCRHLIWFEEKELMEYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV57</accession>
    <name>A0A4Q9NV57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_935805</name>
        <name evidence="13" type="ORF">BD311DRAFT_869411</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Vacuole membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143545">
        <property type="protein sequence ID" value="TBU22363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV57"/>
    <dbReference type="STRING" id="114155.A0A4Q9NV57"/>
    <dbReference type="OMA" id="MGVMKPD"/>
    <dbReference type="OrthoDB" id="1744869at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="11" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="91"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU22363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU54452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="163" mass="16519" checksum="8AC18B3EA9B224A0" modified="2019-07-31" version="1">MSELCPVYAPFFGAMGCTSAIVFTCIGASYGTAKSGVGISAMSVLRPDLMMKCVIPVIMAGIIAIYGLVVSVLISGNLSMEMTLFQGFVQLGAGLSVGLAGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALIMNSRAGDVTGVCSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV61</accession>
    <name>A0A4Q9NV61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1037119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="270" mass="29515" checksum="CA03298BDFD68AE1" modified="2019-07-31" version="1">MLMGDGFAKLLEGAAALAPLPLAAGPAPGQIKNLVTFGDSYTDIDGHEDGGTVWPVFAAQDGNFALFPFAKVGATYSNNLTFRPFPSLFESQLPTYFSEKSNGSLAVLRPENTIYTLWIGTNDVGANALLTGSQAPGVTLVDTATCAVNWVKTLYDSGARNFIFQNMIPLETTPLYAPDSYLNLYCDSQRNTTEWSVFMREPTTAGNAIARLELQFIAPTLHGAHIGLFDSHALLADMYARPKLYLKRLGAVQRHRRGPRMRLPVRRKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW47</accession>
    <name>A0A4Q9NW47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_976764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW47"/>
    <dbReference type="STRING" id="114155.A0A4Q9NW47"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043803412" evidence="2">
        <location>
            <begin position="26"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="325" mass="33880" checksum="276C2372BF5509F9" modified="2019-07-31" version="1">MTSSTTTATTTLFVLLLCAPALSRADYPNQVRTPSPLWRRASSSSPPRSVPPAGFYNPNDSGGKMLTVAPNTGGLGEPLNIIVSGNSDETVLVDSEDNGGFRNYMISVGFAAECLGQHEGDAQTANLGDGNGQLNETSELRWDYGDPQLGTCQETIDGGNHFRYWIQDGPSANSGAFFLATSYELPIQTGHDILFDGYNLGRDWLVGNATAQSSIIPTANLTNGTTFSGQTSFGGYTYSTDALYLSGILSNSTDGLNHASSVGGNGVEALDGLVAVLTVKVVSSPSATASGARPSISTVPWWSLSATLFLTSLALSSSLLLSPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P073</accession>
    <name>A0A4Q9P073_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_944302</name>
        <name evidence="12" type="ORF">BD311DRAFT_775908</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P073"/>
    <dbReference type="STRING" id="114155.A0A4Q9P073"/>
    <dbReference type="OMA" id="HHGNISH"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="188"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="257"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="401"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU31573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="418" mass="47161" checksum="D0932D7E66683B52" modified="2019-07-31" version="1">MSRRNHSEASSEAPSSRPRRSTRLSSSSASSSVEPEELPRRRLWRREPVGIRTPSDDEVARQGGISRATRPKFSRAFEDAGFESLSWKKDRRRVAREFAPVTQSADDIPTDLQDRINALSPEARRASNLQAIFEAEIAANTAEDEPNAPPIRIINDVDDEPTPPMEFYYTNLMWHGADVPRPDFEALKGCGCIGPCNPNSKTCACVRRNKQYWDGGGFMYDQKGKLKHHQYPIFECNINCGCSDDCPNRVMQRGRQYEIAIQKTEAKGWGVFAGPKRIPAYSFLGVYAGEYLTDQEGEKRGLYYNSFGRTYLFDVDFYHVKKDEDEPPKYCIDAYHAGNNHSCDPNCAIVAGYINESNIDKPLLTIFTIKDVEPYEELCFSYFGVDEEDKPALAAQANGAVYVPCRCGTAKCKGFLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P0L7</accession>
    <name>A0A4Q9P0L7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_842118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P0L7"/>
    <dbReference type="OMA" id="TQTHPNT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007008">
        <property type="term" value="P:outer mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035195">
        <property type="entry name" value="Emr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17237">
        <property type="entry name" value="Emr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12324" checksum="C36BF896691440CB" modified="2019-07-31" version="1">MSNLSSSSSITPTPSTFHNTPTATHPNSVYTVRSGSGPASPPHAGLPPPSPNRSRIPVTPAVLRSIFASSRTALEERSLSRVAFFRFTGFLLSCLCISFAAARGRGIKSGAALLGVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1I9</accession>
    <name>A0A4Q9P1I9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor IIA, alpha/beta subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_902909</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIA subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1I9"/>
    <dbReference type="STRING" id="114155.A0A4Q9P1I9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07976">
        <property type="entry name" value="TFIIA_alpha_beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004855">
        <property type="entry name" value="TFIIA_asu/bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12694:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIA SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03153">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01371">
        <property type="entry name" value="TFIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47396">
        <property type="entry name" value="Transcription factor IIA (TFIIA), alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="227"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="316" mass="33581" checksum="ABE62F47CF73E9B3" modified="2019-07-31" version="1">MSNKIVPSIYRAVIDDVIANIKPEFDDFGVSEEVLAELQSKWEAKVIASHVADFEPPAPPPAPAPAHTAYPPHPMHTMQHGHYPPHTAYAPPPHPMQVATQPHVKTEPVDGRYVLSGPQSMAQYGIPTLSGPQIPSRPVAPGQQIPSYPPINGARPPSAAGQAPPPPTARYPPAVATQPVAARIPQVDGPSASASTSRIPQVDGPSSSSSESPSPPPSQNNYAPRASHPSLPQPSLNSSPAKVDDSEAINSDLDDSDSDNEQEGIEGGTADTDIVFCTYDKVARVKNKWKCVLKDGMIHVNGKDYLFAKCTGYVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1Q0</accession>
    <name>A0A4Q9P1Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_927237</name>
        <name evidence="2" type="ORF">BD311DRAFT_749403</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1Q0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P1Q0"/>
    <dbReference type="OrthoDB" id="2159786at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053029">
        <property type="entry name" value="RNA_pol_I-specific_init_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007224">
        <property type="entry name" value="TIF_Rrn11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28244:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04090">
        <property type="entry name" value="Rrn11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="255" mass="29478" checksum="C2BE85D790CDC374" modified="2019-07-31" version="1">MSSSEYSFIFSSLGSKQPNNTRKVHIRRLYDILQLCIQRQDWARAKHAWAILARCREVDWRAMWSTSVLLLGEGGAQDELTQINEDRVRFLSIMMRQHPDERESILKELVLRLIHAGMHRRALEQLDLYLPSYPYQDNPVLHVYAGLVTLYLAQPENDVSSETNYRTGWDLNLVRDAQAHFERARIVDPSNVVAEAFLSQLPGATEPARDRHSPESDDDTMRVDETVQARKRTRTGSTAGRDRMLLATMNRERSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4G0</accession>
    <name>A0A4Q9P4G0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_944606</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4G0"/>
    <dbReference type="OMA" id="YTSHGNR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044343048" evidence="3">
        <location>
            <begin position="30"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="567"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="587" mass="62054" checksum="B8E61F315851D100" modified="2019-07-31" version="1">MSSARRTSPWATSLFRTLCLLAAVDSTFAAVAITPPATPPSATANVVYSNFLGISLELSFINYYMGNTTDQIPAPFISYLSTLQKHASGKPVRLRLGGNSMDSSTYVPSQPDIVEFTDPNANSNDQPVNYGPQLFDVMKGVSSQVGGAQYLIGLSLRVPNSTNIPLVAGDASKALGDELDAYLLGNEPDLYTGHGQRPYLSNYTTQDYIGDYSVVFNSLKATPQGDVLDEDKIAGPTICCAWNLASVLQSGWFDQYKQQLKYITLQHYPQDTCSGHPHFGIEWYLVHSNTVGLAQWQQDGIQIAKQANKPVLMDEFNSISCGGTDGISNVFGVSLWTTDYALQMAAVGYAGAYLHTRERGVTYNLFDPPAGPAGNAGAWTTNAPYYGMLPVYEALESSSGSRVVDLNVKNGMYDATQVHAAYAIYDGADSTVRSLVVINYKNASGTTSDYAIDPSFIPATNSSITIRTLAAPSVAERTNIAWGGQTWAGVGDGNPVPATFAGSVPDKTIACAGGCTIQVPGPGLAVIFVGNNPANSANATSNNGAHSSSTGASSPTHTTNSGTGRTASGIATVGLFSILVAFLIHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P643</accession>
    <name>A0A4Q9P643_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED5</name>
        <name evidence="10" type="ORF">BD310DRAFT_872131</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P643"/>
    <dbReference type="STRING" id="114155.A0A4Q9P643"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014801">
        <property type="entry name" value="Mediator_Med5_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35784:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08689">
        <property type="entry name" value="Med5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU62013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="950" mass="103729" checksum="21DAA1C9C1B94736" modified="2019-07-31" version="1">MSLAELTRNAFQSGITARKWLALCKLFISKNLSHNAAHSIETEISNSVLVLFRDYPGDPTLQGYLKEAIQDGVLSLPIFLTAFLQAAQSANLHNPATLDMLCRVVLDHHYASGMPTMGSLVPFGEPTTRLLSTVQYAMGLLRTAFMLPVSHFHQLTTSASELLVLLLSCVTDTSQISAAQAMLYLAEANDLLQNVRLHAELRPVLETFAFSLSMLVPDDPNQAREAQMMHTLQFALGRGETVLSASSETDIVACSLILNHLIFCRASDFGSGDGPHAVAIFVGLLRGSSWAPWMFYAQLIISSLTCLAQSISPTGPTRASAIWRAFTIGRLPHLLAAFRKAGRPEAISESEWHSALQIALPHVLQRVDLLEKVDNNGQPGGSDAGSDKSVVQHSFISEFLYQLLSVGVVEQAVVATINPNLSNDFHPRVATEAQEMGVDLPGYFEAKLCPEATPEDIEVLLYRAWKDPCCHAAFAEVVVKRFTTSTKNLDAESLGLVCKMLSKHEMALDMLSLHAKISDLVAHALAFIEDYDCETVGDPQTAVSHLGDVVLFVETTIVRFNLASLSFKVGERVINPDYMRTAGLQLRPGDLKGDEMPAFSSWTKALFDPGSEGIEDTILRTTRPKTLLKITPSLFSFAIAQAMDRKMDKEVLNNGISYFLGPLLNWTLAGVIRSLLMDIQRRSYNAPVHLEVLKTLLTSSSCPPTVLTLSAPSVLRLFPDPFPQHSKRYLQDFDPKPVRQAARQALGLPAEEVPNPMPMDPSTTQWSSQSRQLIANALSAARSGRAPALDIDRCLLLCPPTKFLGALWTQLLLAATMADMEAPRRLATFVLTVPRSPRLPPLLPIFLHMVLPSLVASADGMSGTEQTITVELLVAVISSSLTAALHLEWALLTTCGEERFVLGQSVTSMARRLSADLKRRGAGTTAGMILQRLTAMQPFVANFPSFAAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9M2</accession>
    <name>A0A4Q9P9M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1043580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="ML145335">
        <property type="protein sequence ID" value="TBU51360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9M2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020911747" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU51360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="503" mass="56398" checksum="AD59D9A697AAF4AB" modified="2019-07-31" version="1">MKSPGVGLLALLSLILPFAHGTRAGAQGVGDQLRFEQQAFSRYDDGLFTPFGELSTLSSTEFTEFGHPAFPRHSVRVKKSDFCDGTVQAYTGYIDVQARHLFFYFFESRRDPDTDDVVFWTNGGPGGSSSLGLFMELGPCRVTSPNSTEFHPQSWNEYSNIFFIDQPVDVGFSYAEYGEAVSTTVEAADDVAAFVAIFFEHFTKFKGRALHLAGESYGGRYLPVFASAIYDQNAKLVEAGLTPVNLTSVMIGNGCTDFKSIMPSWYNAQCEDPTFPPTLSISECVRMKQLLPRCEKRYKESCEDVFDAIDCNAATEFCDRSLNGLLYNKVNLYDRSYPCNGLDMDTECYPIMNNIMEYLSDKTLQERLGVDPARRGPFKRHSTKVSSAFFATSDFWSFPAHYYLAALLERNIRVLIYVGQTDFICHWMGNEKMTLELEWTENEAFRRDPLRAWTVNGSVAGVTRTGGGLTFATIDGAGHFAPYDKPIESLELVNRWLAGKELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBM1</accession>
    <name>A0A4Q9PBM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_910692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145330">
        <property type="protein sequence ID" value="TBU51385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBM1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18786" checksum="3A78F9BAACB85902" modified="2019-07-31" version="1">MYLLGSWYAYAVIPAGVLVLGTAGFAVATSIEMLLYAENFLELRTLHDVVLAASFIIFLTRSRTGFRRIIDQVPIYHAYPGRPQPVVTSISYVNAVLAVANSRRTFTESSRDLDGFGTFGLSVHPQPSQGSPIRMEHFNASTSSNAEGIDLHLKALPTDSRRNNLGVDSAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCX7</accession>
    <name>A0A4Q9PCX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_835366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145403">
        <property type="protein sequence ID" value="TBU51087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCX7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26008" checksum="1323EBC7C273BDC3" modified="2019-07-31" version="1">MRSPALPWEVIEMAINHCSGDTATLRALALTCSQLRPCSTTVLFKHVDTQSHDQLSLFYHAVQARPHLQLVVRSLSFPLEIFSPFSLHLLSILPRLHHVAFTGRSLSSVRYIALKQSTPISGMQFAISLRSLMIRNATLHSQTDFLDFLMNFPNMENLTCEYLSFHVLLSASGGPILNVRKTISWSDEFSKLSFHPLSEKWVLPDDVKCESCSSTMPPELYADWSSGQTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD38</accession>
    <name>A0A4Q9PD38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_837699</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD38"/>
    <dbReference type="STRING" id="114155.A0A4Q9PD38"/>
    <dbReference type="OMA" id="HSGHLRW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU66138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="437" mass="49485" checksum="2FB1C46BF38F1A45" modified="2019-07-31" version="1">MSITLVSNSYLDENSAKIRAKPVPWEGYQRAGLITPDELALIKKVDRQTRPKIESLHASDGQTYALLYLRLLKKLQRIDTQSCILVLIADALTDHEERIPLFTTASQSDPELPYSPLLRILESQDDFVQLKATQILTVLLSSEKSPLQVQQLQPFLNTLAQFVANNNLNKRDVAVQCLEAVLPRPEVRRAVWANTSLVAGLADILKHNSTPQMSYQVGFCFWLLTFEQEVAEQIQKRFDIIPLLVDVAQGAAKEKVIRVIVATFRNLVSKAPQANLPAMLVAQLLPFAKNLSGRKWTDEDIVEDIQFLRDELSARFDSLTTYDEYRSELLSGHLSWTPVHESDLFWKENATKLNDKDYELLKILIRLLKESNDPTVLAVAAHDVGQYVKHYQLGKKVLTDLGAKTRVMELLSHSDPEVRYQALISVQRLVSHPWAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEG2</accession>
    <name>A0A4Q9PEG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_952166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145218">
        <property type="protein sequence ID" value="TBU53300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEG2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEG2"/>
    <dbReference type="OMA" id="CANAMGM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="52"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27306" checksum="A0886F7F61016D4B" modified="2019-07-31" version="1">MNKPQREALAGLFKSAANIDPRKGTRSTAPTLSIFLALVRPNLTVITAAYVIATGVESEHGGDVHVVHAAKEVILTVKSPHILELSGIGNRNVLEPLGIPLQVDLPSVGENLQDHLIFTSCVFPEKQLVPSLACTGITFLSLHMFSDWADELIEKVEKRIEQNVDKLSPGLKEQYELQLKLLKDKNVPDLEIVVFPVNVHPAGPLKPHIGLLPSIGHPFSRGTIHASSSDPKVQPTIEPNYLTEEIDINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEZ2</accession>
    <name>A0A4Q9PEZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEZ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="35289" checksum="8EC7951DFEF007E2" modified="2019-07-31" version="1">MAGSGDPPGGSSSTNPTGNSATTGNTSGPSTQPTSTSQPPDPVAAALNATAPQVSFSPDQLQAIVQTLATLYQGQQGAAAPATPTATPAVVTAAAFPQFVFAPANPAPAGKSLLDLFPSIEGSVLLEIARHEFRPGDLYKLDPRHKDRATRQVLDVSSGVVSVRDQAPRDYPTFHSLYLPLITFFNVLGGFASTGGDAVALYQLTSSSSEYLARMVQFSQDYQWSAVLAYHFDFHYKRRREMLRGDYSGWATIDTSLQAEHLIGRERARPLGTPKGSAGGSSRPRDTEPCRNFNKGTCASPCHWNRPHKCLGCGATDHGQSACRRANPPAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFH3</accession>
    <name>A0A4Q9PFH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_991480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFH3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="215"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28971" checksum="BC72EFD41E23BBCA" modified="2019-07-31" version="1">MADKLCRNARLNNPLPPDTDFSEEESKELQTLTHLPLVECSCYPAFSAKYLTRLDSSLRPLKRETQRKAISTYIQILSLLPDPTDNPYLGKFLQSPNAAGLPNLVASNFVQGIDWLRPSGPGHICTLLIHFLFWCDTSFGDDNKASIDKATRDALAARVADILAQPGIDRLPESQLIKLERLKGILISIEYMPGGYYLQSTNDFLKGQIRGQEECLACMDEDPGMLCSQCKAVRFCGKECQLKAWRSGHKNRCWVMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH33</accession>
    <name>A0A4Q9PH33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease H-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145241">
        <property type="protein sequence ID" value="TBU52661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH33"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43040:SF1">
        <property type="entry name" value="RIBONUCLEASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="1">
        <location>
            <begin position="14"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18833" checksum="CD4576FF058041CD" modified="2019-07-31" version="1">MQPGTSPQDRFTLVSTYLEAAQAATVLASFPVLIVGCEGESLGHPHGSLTLLSISTPDGSRILLIDVLALRDPNNPSLKPLLALLSSNKVLKVFWDGRTDVLELSLTYGVCVAPVLDLQVAEVVHRSKWQSKDRHLRALAEKTFKSIRNEVLANPAVFDGIYPLIGLDGCLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHB5</accession>
    <name>A0A4Q9PHB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_199883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHB5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20235" checksum="9985E783E6871AFD" modified="2019-07-31" version="1">MADARYRLLFYKTRRHGTQACSACAAAPSPARLQNRLRPHRSLLPLFSTAASLSLARFPLLDAYTICNIGRPLAHHLDSPCSLLSSHLHPVTITLVQRVRSSMAQSCLSGRVSERTVSAIPSMAPAAARGLSSHISKYRARGGLHPGRIYAHPSSGSLPGVSAFRSCGDEANLCPSYLRAASTASVPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHD3</accession>
    <name>A0A4Q9PHD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1042697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145229">
        <property type="protein sequence ID" value="TBU52992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHD3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="251"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="609" mass="68427" checksum="1B6B89B1D0FC6921" modified="2019-07-31" version="1">MRLLNTETGQFEERDPESTKYAILSHTWDAVEQTYEEVRELQRPYASNGVLRSSLAPHNRSLSNPERELRPLWDNPELSAKVRDACTAAREAGYRYIWIDSCCIDKTSSSELSEAINSMYKWYALSAACYAYLADVPFDEDHRASRSSFRRSRWFERGWTLQELIAPLEVIFLSQDWKVIGSKHTLVDLVWDVTGIPEEALLHMESLDAFSVAQRLSWAASRQTTREEDHAYSLLGIFDINMPTLYGEGKRAFRRLQEEIVRRVPDQSLFAWWAIFTGIEARQDLVMTATLQNAARIAFNREGASDLRAVSHDDVFHRLQLSHLPATEYTSTPHGIRTQIPVIPLSFCVPQHAAHYPEKYASSQWYLAILGCEHEDYPGHLLGRVCYIPPSESGVEHLYCGYAAIDPTPERGTDVPELFPLSPDTLSRCRPEIQLKTIYISHPERAIAGSLGAITEPHRQIELTVSSRARHTLLAQGYSVELSGPALDSSAARWLTLSKDNHGIMIAFSHALDNVGRKLTITARVTMRQEPSSSSTREIHGTPISVSWSDYAPWSRSLGARKVTISDPSTSQQLTVALTVSFAGLSYYLLHVAVTTETPVAVAALIVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHR2</accession>
    <name>A0A4Q9PHR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHR2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7868" checksum="946AEF85DD497DDF" modified="2019-07-31" version="1">MTCEEGLWGYVVGTATMPITLPYILCDSKSQYSTMLHPGNEHSIAPFHRYHKRQLEVSSAHIDEATTNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI66</accession>
    <name>A0A4Q9PI66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145208">
        <property type="protein sequence ID" value="TBU53662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI66"/>
    <dbReference type="STRING" id="114155.A0A4Q9PI66"/>
    <dbReference type="OMA" id="RAWASWN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
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        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
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            <begin position="488"/>
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        <source>
            <dbReference type="EMBL" id="TBU53662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="532" mass="59716" checksum="4CBC937CEFED3CE1" modified="2019-07-31" version="1">MKVAVVGSGVSGLGATWLLNEYTVHEVHLFEADSRLGGHANTVIFDRPGKKPTDVDTSNVTKIVFNPSTYPNFINFLNIFPDLAERIIKTEMTFSVSRDMGFFEWAGDNLLTIFCQPSRLLDLQMWRLIYDVLRFNVSAQRFIIELESKTSADEEISIGTYLQRHGYSDSFRDNYLIPMTAAIWSTPPDKCALDFPAKTLIQFMLNHHLLQITGKPKWLTLRGGRQVGLMSQFIISRLSPSRLHLSTPIKALRSAPLSDHASQPHRVELTTASGEKMLFDHVILACHTDTTVEILKEGGGMTSEETRILESFKWNRNEAVLHCDEQLMPKARIAWSCWNYLTKSVTDKAGNYLPNINQVSLLDWMNALQHLSMKDHGPVLVTLNPPFDPKPSLTFGRYKYDHPILSEKAIRAQSLLPSIQGTRGISYAGAWTKYGFHEDGFTSGLRAAAAVAGPSAKLPFEIVPADRQPDRNVLRLARAFDFFESSGAAWLLGSLFVFVLALLRRTVEGLGVNLRHLEQTHETAEKAKAKDE</sequence>
</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="TBU53846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7337" checksum="9E13EFFCAF401841" modified="2019-07-31" version="1">MSDVPPAFGRFHAVFCICRAYILKQPLEIPGRLTGSCGRMLRRAYGAEESMMYVFSILRMVLAHA</sequence>
</entry>
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    <accession>A0A4Q9PJU5</accession>
    <name>A0A4Q9PJU5_9APHY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_936013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
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</entry>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15300" checksum="382AF62D8E738404" modified="2019-07-31" version="1">MCPAMRLRGAHRLCPSAFKRDIKRASHRYQDIEDQGESGITTRADDGQTRSALDCMDHGHVDLCASRRPSILDKLGGFAAVRVRPKGLWHAQFSQGGPLQPTLDWYGKEAISEGAGEMHVAEGDQRERGQQASRMLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK80</accession>
    <name>A0A4Q9PK80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_71879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="43489" checksum="F468C7BF7530CF5D" modified="2019-07-31" version="1">MLTAYLLLAGLISATYSQLVYLACWQARFPAHLPLLFITCTFLLTLSAVVIVFIGPLIFHLALFASQSARYATTHTILHTIRHLSVFANLAYCLIRITAHLAIDRATTALAIARVRAQATYVSVLASSKAAYVKVLAVRHLTAISIKDFLTRLVDRSVSLIAASILLCGRRIITLFLTLLLSCIRPLRLLSSVSLRVSARVLVLATPTALHVVRLTWITLATPLRIILCHITGPIVCLASRILSLAFVYILSTSFRLACLVTPSVTPILLRCAIYVVVPGLLCLLRLSCVILSALSKGMFIGLQMYLQYMLQPNDSCDTSIRFRTLCPSSCRPLALAERSQRISDQIVCHTSPETLRLDCSISSSTVTSMTADETLCDIPAQCDITLETFEHKLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKC2</accession>
    <name>A0A4Q9PKC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BD310DRAFT_951348</name>
    </gene>
    <organism evidence="3 4">
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKC2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="566" mass="61980" checksum="22067E0D584BD1C7" modified="2019-07-31" version="1">MTQVMVKFWQVLPMGRSHLDIAIGLHLPLILWRAIASPINSAVAYIRFPMHGHVNTTRVMAASNLALCTYSGRRPDSGHSIFCTLRSPDNAGIGFDLRPDVTVYWGTILEFTISTSKLLAHAVNGIDDASTSVPIIGLTEAARACILTATFTVNVCIGDAIVWWRARVLYHGNRKVRHVCCALLSSTFVLGIVSTRRSVLVQSSRPGSIPIVYNGDVFGTAAIALSLATNVFSTTLIGYKAWKHRQFMREHLGAAGSSTLVTLKITALLVESGTIYCLVWVEFLVYHVVGDMVPGIHGGPWNGATFYHEACIAPIVAIYPMVIVVLVAVNKSQLEHGITRGQMSISTWGVASGPHAHDIPSHRMTQLSEGGCPFASRITRTGEEEAQVGSSVDTRVPGRSSVDSDRISSLKDHEKPGAVEMVILPTDLERFMSPRVLKMGVVDSCGPPLNVLDAPVRKEEQDVGLHSFRTHCRCGSDTNTETGAKARHSRILPLLTQRLHLLAAHSINVTEHEEYFPSLQYNARRMGFGMTWMHYGSSVLTAVHTKNITHTHIVPRQRYKAIGNMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKL7</accession>
    <name>A0A4Q9PKL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1031913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKL7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="17213" checksum="38AD49CE8FFEFA42" modified="2019-07-31" version="1">MVLVDEQGVYGGLLEKYSADDLGTTLKKWRRSARESETRPWSRFPPAAGGRRGPQIRKRWMRGCLDIFEMQYHRPRCRGCHRRTRSCALASEPDAVAGWGRRGANNILGAYAQGLQLLLRNRRDEPCLRTTELPRSRQGQEQSIERESQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLX8</accession>
    <name>A0A4Q9PLX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UbiA prenyltransferase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_884837</name>
        <name evidence="6" type="ORF">BD311DRAFT_753033</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143400">
        <property type="protein sequence ID" value="TBU31307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLX8"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU31307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU55136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="290" mass="32456" checksum="667F06762A870B5A" modified="2019-07-31" version="1">MDIAPILVPLRQALYHANTLYLFTKSDLKTIFFPITLFAWCTVPNTNSLAFTRSALWTWLHLLQFCVSNQSLSPDEDAQNKPWRPIPAGRLSVRQATRLRWALLPLCLFLSFSFGIPAVGAVLMVGILLHNELKLDSHWFTRNVLNAIGYATFDAGAMTVAQAGAHLSFSYPALAAHYTSIAIVLTTIHAQDFQDEEGDRVQKRRTIPIVMPAAGRLSMPVGLTLWSLGLSEGWHLPNAHRLALITIGLYVGSRFYFLRSPGADKTSYRLYNVWLAIARISPMYGRIPVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPM0</accession>
    <name>A0A4Q9PPM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_632786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10339" checksum="93BFE93131634759" modified="2019-07-31" version="1">MKTLVPPPPVLGMASGRYMATLFYTYPYHNFRRIAGASAADYDASACGYVEDLVRLNRAAYCRNHGKPYVYGNKRGLPSMRGTPGCLQPYPMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPN0</accession>
    <name>A0A4Q9PPN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_823922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPN0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23564" checksum="059D502B1BECC9BC" modified="2019-07-31" version="1" fragment="single">QGAHQHAHFASIADTVTTPTITQGLDVVLGLCALLRKPVCVATGNNKYPSLTHAISLTEELDIPATSERIWMLENLVRQLPTSTGSSTTSSKTLRKTETVSSDVPSASISLSSPDTSREPSPIRSGTATLRLGRTKAPSPLTTDGEDPLFLDEEELVPPPKRKCTLKERLAPTLREHLDDPMDEADNTVSLGLTDAEEEIDDFFKRTWYCRKFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR56</accession>
    <name>A0A4Q9PR56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_978590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50671" checksum="E01F285E9CBE38C4" modified="2019-07-31" version="1">MPLLNITPPEFPPFPRPFPTEVEELIIDILSDHPRALCNCSLACRRWFPRSRYRLLCSVSIKSRAGLASLCKLLDSHPLYRTWICSVAVTPIVEEEALLLSGVFPTPLLSTRLPNLRRWEIIHRASRSRIPSNEQSLSFHKATLTQLQCYSSSIEELRLSALRFTSAAELVRLVGSFPCLRCLAWDDIGFDSGRDHLHEANRLLAYRRLGGLTTLDVSIGLQNAPITNFILEVVHSTLRALILRQPKDAEWTSAHPPRVNEPSLRQLGALTLHMNHNSDVAAVPFDWLPLLSEAFRTLQTFDCASTLTTFTLHIHFRSEAPGPRPRLRKPSRLSGVSRSLRFLNDGERCQRLKGVLHEHSHLHRFAISVHFPREQRRRALLLRHLREEGFFALHWVGLLGVDPGSNECVASHREPRDAGESWTVQIVRGCAGASVGSSGPPATENGDESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRD1</accession>
    <name>A0A4Q9PRD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_930637</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRD1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU56845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="492" mass="54647" checksum="3B52CDC96C6175F9" modified="2019-07-31" version="1">MMVISTLPHCVEADIEACSPDREKDEKQASITHLEDALDVDSEVYVVDQEAERRLVRRIDLRMITGSTAMYVLCFIDRSNIGNAKILNNDTGNSLQQSLRLTNNQYIIALMVFYVAYTVFEVPSNYLLKKYKPSRWFSFLMLAWGAMTMLIAATRNYGGLLATRFLLGMFEAGLFPGLIYCLTFWYKPNERAVRVALIVAGATLGGAFGSAIAFGIGTVNGAHGLEGWRWLFLIEGAASCFIAPFILWFYPDYPETVSWLSPEERELATERIKGVASLGHEAITWKDARDTLLDWRLYLHHWIWIAYSVGFSSISLFTPTIVQGLGFAGLRAQLFTVPPYALAFFVVTAVAWISDRFEMRAWAMAASFAICGISFVIEGSLPPTAFTARYAVLCVGVPFAYAVSGPTLSWLTGNLRGTGASTLAVPLNGSFSTFGQIIGLFIYKTSESPGFPTGHYTNAGFMFSGALAGLVLRYVYTRRNRQLSPGEPRWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRV4</accession>
    <name>A0A4Q9PRV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear condensing complex subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_822142</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRV4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRV4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="595"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="540"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="950"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="969"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="988"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1002"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1012"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU57126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1089" mass="122771" checksum="88D56FBB7386B934" modified="2019-07-31" version="1">MPARNAAPFDLESLNAALPKIFDQVQNTSANHQKNYVALYKLHREAEQVKSSVQNDRSTKLVGEKAFWDVFDDMMLRVLPVKKGVGQADRTVKFMGGYTKFAMEKNFEYRKERELDEDEDTFADRFITHAVRFFLEGCTAKDKVVRMRVLQCIAETITNLGAIDEDLYAELRAALLDRLRDKEPSVRSYAVLALSKLAISEETAELDEDEPTILDMLIETMTYDPAAEVRRAAVTHLPATPYTLPALLARTRDVDAATRRLVYVNVLEKYCTGVGEDSRTRVGFTHPRVLTIAQREQIVRNGLGDREDIVKKAAAQLLGVWVDVVRTEAGKEVKPEENVKRENGEEVIEDLVAFLNLFDLEEGKVAEDALGSVFDTRVDIFEHIEFSDDYWTNLTPERAFLARVFVDKCISKEAHARVEATLPVTTAMAFRIQDAYNALAEQMKEESAYDEDDDEEARAAREEARLDRELTIAELLRLALNLDYKDEIGRRKMSLLVRGMIAQDFLSESLLARPLDVLRVISESEQDLIRVVVEVVHELRDPPTEEESEVKADMSVDPDDSMTEAGGSPKKPKLPKPVAEMTPEEKARMDVVDLRCLSLCIGMLERVNGTFEDNPVLQGILGELVIPAVKRREMALREKGLTCLGLCCLIARHMAASSFQLFLNQVAAAPEVLKLRVLQIIFDILMVHESVFLAPGSENEGRIVMFLLAMLGSDQTDKVHALVCAGTAKLMLAGLLADEQVLLALVLAYMSPETVGNHELRQCLSYFFPVYSYSSAENQRRMQRTFIPMFEWLTKAYHTWDGEEDMVAPSQAALMFADWTDPIQAAYAVKGLRKDAHKDPIHLDLAHDILKALFSIKYSKEDKKALYQVLGKLYLPDEVDADKVRILKLLVDNLRTRRPPRDTAGKNALIKFDSALAKRYEKQLENFSEDEFRQLEELKDLFEFLDDIVPLEEDEDEPPKKGRKRRSMSVATETTSVMSDDRSPPPSPRKKSKAKRRRLSQSDDESDDDALTETSRASPSATPAPTRSMPKRNAGEKGRNATKKAIQETIVISSDDEDEDEEDDDGEGDEDDENNATPVAKAKANGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS13</accession>
    <name>A0A4Q9PS13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_929853</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS13"/>
    <dbReference type="STRING" id="114155.A0A4Q9PS13"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="154"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU57196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="23455" checksum="1E98FEC3D836A43B" modified="2019-07-31" version="1">MTVYYTLTFLLLVSEMATFVLLVSPLPYVVRKRLFHFLSESPLVAKLAYGVKIAFIFITILFVDALQRMWRITAEADLTKSQQGTADVRAETNIAARKFYAQRNVYLTGFCLFLSLILTRTFYILLDLIHTQEEYAKLKQSTSGKSTGGDQTQQIQELKAKLAAAEKKAADYDIVKKQAEQNAKEYDRLATEFNAKTGNISDKRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSI2</accession>
    <name>A0A4Q9PSI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_880929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PSI2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="507"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU57324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1505" mass="168368" checksum="703C7AF5645D6C60" modified="2019-07-31" version="1">MAQSYFPASASASAGSPQPLVESSPKHLNEGVQEAYLEHKNSPCSASRLLNALDNTKSILGDLRQFNKDDWVVRYPQLQEQPATAESSATTKRRGMRRSLSFPDDPSFQADVVVSPAKAGLTRSVTLASIADKEEDPAAEYEEDGDRLVSAAEVSDFNVFRLDLKLGPHGSSSSPAALVAQLEKSSIANLLDDRVVNAVNHLNKLRSRIEDTSSKVLVTGDLNAGKSTFVNALLGREIMPVDQQPCTTAFCEVHDARENDGKEEVHILKEGATYSAQDESTFTRASLSDLDAIVSENENDSQVLKIYLADPRDPQASLLSNGVVDISLIDAPGLNRDNTHTTRVFARQEEIDIVVFVVSAENHFTLSAKEFLTNASNEKAYLFIVVNKYEQIRDKAKCKRMVLEQIKQLSPRTYEDAEDLVHFVDSQHALHEGTSSFGKLESALRSFVLVKRAKSKLAPASTYLTKLLADVDLLVGTNAIVAQKELERARDDLNRVRPVLEKMKGSRETLEESLESIEEDGASHSRSRTKELLTDAVERIGQGKLGVDAPSVHLPSYPGLLGIWDYAREVRRTLLASLDAAVKLAEEEARIVTIEAVDKIAQLGDKHLPEGVERSKRVFMPEAMFSFRADKKGNRKSRQASRTVVAGGMYGLGIGLAQRPDMLETTFFDLFDVQHQFWIHFGEGKDQQTEEVTVSTLGYASVGLGALTMVGGKAIGARSLVEGIVRVCDIFENETARKWAAPVLGAVTIGLVTYFVLELPSTIPKTVGRRIKASLAKESEEKGEESSFIGANATRVSREVRKVLRLAGWDVRERFRAAMEEHGREVHGAEEMERTAMKALDRFCEIEKRTGEVRESVVLYITNPHVLLYDSELTMQSGIFVPHRALESAMDEHMSNVISQLQQLVASINDVHTQQIGRLASGSDAETLQKWRSFDTALLESSRQIRYHLNGEAPINSLPREILSEIFALASCDGFDTRNLASEDFSETSIMLPKNLRRITTVCRAWRDVALSAAFLWSHFVVDTDWDERAYTQQLRLSQNAPTKLYIQKDSRQRAAARLLKDLGSRLRELYIFDYSMEWEHILPVLPVTTSLLTQVSIEIAPRSRFEPRGPLENEFLSGVLGNLRRFNLSGAPFLPTGQFPNLTYLHAGGGGPHQLSSLLSFLSAAPKLEIILLSLRLEQDLPQCHHRTVHLPHLRRCALNMGDIHAEILPQIAFPPTCLVLFGTLTDALDEVLSAEDMDAHIRTIVGLLPTHPFAQHLTRLRIIPGNRGWDSVADTDNTYHVQLSDEQGASGVHFEVSRIFQSSDLRDPEDIDYFAEDLADVFWCPGGVFLAADVKELWLHKWTEFLSPTLLACFPSLETVGLVLSRKRRYDEPIPPALGRGYDGYIHCPTLTTVCLYTCDADAVDDMRDILQQRKRGGHRVRRLAIECKDAKAHRRALKLDKYVHELFVTMAKKDVKWWEDCTDPWEGQLREWPDWPEWFEWRRQDRAFANDLSEESDSENGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSU1</accession>
    <name>A0A4Q9PSU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_821513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSU1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="16214" checksum="9644FC18EE6CE761" modified="2019-07-31" version="1" fragment="single">LALFVYDFLITFGDEVNLFWLPRRLNGPSILFFLNRYLALTVQLYGFTPKPASHEVYFRYSVNAWYTAFAVIASLQIIPWAAFSALRSYALCPSPHRMAISTAVFALFSVPFVVNMIVRTLIHILHYWQPYNRVSIERAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT42</accession>
    <name>A0A4Q9PT42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_929222</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT42"/>
    <dbReference type="STRING" id="114155.A0A4Q9PT42"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="415"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="649" mass="73453" checksum="C1AEA166D78FA929" modified="2019-07-31" version="1">MTTQLSDPSGIPAEVNSNAVPDPPSRPQRTEIARYDLYFNQRNSRYELRKSRRPATVEKISRKKPILLVKRRIDSRGQLEGTVIEIHHEGLQALLAEINRGVKGLDLTSKTPSVSRELFFHSRAQLVERGRTLEASHQPQDQDLMDGIKAALRLIEEDLADTIKDFNLLVSKKQITYAYLWALFPPNCYVHGYDSATDQHFVAHAKASQYRYTREGNYLEIQCDIIVHDATEFGLAEYEFKIPQFSGAYSILELPVCPLDYYPDSAALREKAISRGKVYANLRMHFYQHQGIATLCVGNARLRLVTNERVMVDVESFFRYQARASFARTVDRRLNPEELSDLELMICTPVLLGFCFNTKSWGAFAIDRITEVAWSDEPFERLVLPKRHKLLIQSLVTQHASRPAGFDDIVADKGRGLVGLLCGNPGCGKTLTAEAVAEITRKPLYTVSAGELGTTPEDTDGHLRRILRLGERWDAVVLLDEADVFLQERDKTDVSRNALVSIFLRQVEYHPGILIFTTNLIQQMDPAFESRIHFCVKYADLDFASRKKVWQTFLSKAGVADTAIGERDLSHLAKHPLNGRQIKNIVSTARSIASSESSALAPSHVQTVLEVMQDWHSAKYERTWNLHPIVLGAAGVVCSLVYLRRFARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTA2</accession>
    <name>A0A4Q9PTA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_880490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTA2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="406" mass="46160" checksum="3BAC4B49210B02B0" modified="2019-07-31" version="1">MPVTFQVAKHDANAIALPGYKQGGPQSPVEDLLKESCYKQWKESGEILQSSVTDSALPTLRSNKNGFVHTVVEAHGRHHHLRIRPDDVWIAILSQLSFYVNKHADELREYFVAHEGKKELWVYAVGTRYTVDFGRLARQMSDQIHQHVVDKTLVEWILPDFTTSTTNDTTICAILLMSTLQAYFSYGIGIICGIPSVTLEGEKADWERLYKRLDRLPELGEEPEQWAAMLRPILRRFVEAFDGQPDIPFWEHVVNRNDRICGLDLISGWITAFCVWDQDGKWLARNRRAGSQSLGSIKTEGNYTLDGIPYFELDMKDIPSGYGDVNVLVDDNGTTFDCKMVAGHVAATISKSSDDGVYDTLSPAPQWFMYVKGDKPRRGYEEEEAEKLARLMRDFEVKWGKHPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUJ3</accession>
    <name>A0A4Q9PUJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_948852</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUJ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="504" mass="56804" checksum="EE9F8CE321D238AD" modified="2019-07-31" version="1">MYDLPPALYGALAVLAAVYLFRWRNDPIHKIPTLGGPSVPILSYLSAFRYVLNSRQILKIGYEKFSDSSFKVALLDQWMVVVNGPQLLDEIRKRPDEELSFLESTEDFLQITWILGPEPHDDPYHIDLIKDKLTRSLPAVLPDVVDELRSAMPWYIPTHGNEWTTIDAIPTVQKVVARLSNRVFVGLPICRNEEYLRLAVTVTRDIVRDGFLLKLFPKAFKPLVASWMSHAKRTIRRALPYLRPVITERKAKIKEHGLGEDWPGKPNDLLQWIIEQAIPRGVDDESIAARVLLVNFAAIHTSSMSVTQALYHLAAAPGYIQPLREEVESITAVEGWTKAAMGKMWKLDSFLKESQRYNGIGLTSVGRKALKDVLLSDGTLIPAGTLVVANSYPMHHDDEYYPNAGEFDPFRFARMRELEGEGTKHQFVNTSTSYVPFGVGRHACPGRFFAANELKAMLAYIVVNYDVKIDGDGARPPNVYFANSVIPNQKGKIMFRKRQVTGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUJ7</accession>
    <name>A0A4Q9PUJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">IgA peptidase M64-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927992</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUJ7"/>
    <dbReference type="OMA" id="MPIQAYP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019026">
        <property type="entry name" value="Peptidase_M64_IgA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09471">
        <property type="entry name" value="Peptidase_M64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="625" mass="69341" checksum="F657B92BB2126B1E" modified="2019-07-31" version="1">MKRVLFGILLGLCLYAASASAADVTERPYELIVQRDSDTLKCSHLALHDTQHFRGLPESGYLKSKVLETGEERTQFIAETEEDVWERAESLCGPRETWDFHTLIRSTATPYDASQAVLRPQQSTSPQLEVFPLITSGDSSNRVDLVFFADGYTAEEKDKFLDDAFRLAEDISGNQTFYTVKPLLNFWAAFVPSKESGVGVGGEPKDTVFGLYRPGTELRGVYYSKPEVAREACDALGTQCDYPILMGNDPLYGGLGGEFTVITPSLANGPLVLRHELGHSVIDVGEEYDGGFAYFGVNAAHNTTTSGIPWTHWLSPAPDAHAHVHDDAEHHHGHVYGAAEAVKPKDDIRVERAVMPLQDYAWTLLNTSAPWSTRFNSSGQYAWHLVRFSLSGLPNATDLVVSLDGKDLHWAPRADVGVDRWHYDVKLNSTLSGGEHEVTFELKNQKREGEAQLCSVEVLEFGDENEFVTTPGHYSLYPTFSEKNETTYRPTNEDCLMRIVTTPNFCKACVEGLWHALLRRVSLVDSLTPSCSQSTLEPERVLDLSLVPLAHLRDAPVGVEEGYAITWVRDGVEVPAFANQTRLVDDANTVGSYVARVKYWTEEVKVDPEGLLETIVGVVVTTRCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW28</accession>
    <name>A0A4Q9PW28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">S5 DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_926900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW28"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000002">
        <property type="entry name" value="30S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48277:SF1">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="6">
        <location>
            <begin position="147"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU58584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="326" mass="36697" checksum="2821DE16B94F38EC" modified="2019-07-31" version="1">MAMSSKAARLAFSTSARQSCRRFPPAVSTFRHYSTPTKRDILSNDDLRRIAQEHQFAEAIEQSQYFPNLMTPDALLDLHNSKTFPPSRHTPYANTVVVRNNPSIFRVAREIEEGQREEAVVVDEIESSTDAMKPIKFLHLPPGELNKLYRASVLRFVKQQTGKGKIERIAILIVVGNGNGLLGLGEGKGADFPSALAKAFPQAVRNMDYVERFEDRTIWTEMESKFCSTRILLRPRPVGFGLACNPIIHEVLKVAGIKDASAKVWGSRNQYQVMKAIVRMLLPGREPTLMGNGLGRRGRTMEKGKELRSAMEIERDRGRRIVPLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWE6</accession>
    <name>A0A4Q9PWE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_443959</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWE6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWE6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="10">
        <location>
            <begin position="259"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="334"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="11">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="505" mass="57974" checksum="89C00AFA5FA86283" modified="2019-07-31" version="1">MSEHEYLPSPSPEEDWGDTDREWVVDGVVGESIDAFGQKRYEVKWGEGWKRNDGTNTTWEHPREDLEELIDKWERKQTAKRMEKAKASPAIAINVEDWHMLHENRTIERARGYEELKKLYIRGDPRQPIDFDGQLKRLKPSSRESKTPGSGASSSGPSQRPIKPLPKRSFRRLPSSSPAPDSEEEKKTGRRAPPRETKRRRPLEKKWAESLNGAAPVTFVNDISYEEVPPLVPDFQYLERRYVRADGVSSAEHRREFLLSCECERRCLDADDCECQKPSGLQTDDGHGIFAYNKKKLFNFKLPLGMGLEVIECNENCTCDERCHNRVAQLPRDVPIEIFLTQSHGWGARATFPVPRGKVIGVYTGELITREVAEQRHALGDGRKSYIFDLDVHEGDDDDDEDQSARRYSVDGYAHGNWTRFVNHSCEPNMRVVPVVWDTIPELKQPFLAFVATEDIPPRTELTIDYDPNAALEAQKNHSKRPRTRPEGARECMCNTESCRGWIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXC1</accession>
    <name>A0A4Q9PXC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_412519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1445" mass="156692" checksum="43C9BC7C33E47084" modified="2019-07-31" version="1">MSFCEGDGAFGPQSSCRNFDFTVVFENGVLTILPNGLFLLTAIIFAVQTRPRLSLSRRHIPVFIPFFLLLTTGALSIGGWKTASAELPHKANALVTAALALDLVSALVLILLIPIFGRSRYILFVASLYLLLTLILDTSRVRTFAIAGSAATSELFFASFLAHYATRFASLVVLSFPSLFAKNDGALENAGFLSHIFVTWALPLMWKGRHGNLEIEQLPSLDPDMDTTELYARFEVYWKAERTTHGDNASLVRVLALTFYPTFLGPVVPAAIRSLAQAVEPLMVNAIINFLQSYTTSGETPDPAQWGWALAGAFAIVFLGLAGATGQYFYYVYRGGAYIRAALVEAIYRKTLVLSADSLADAAGGDASNLMSVDIERITLAIDPLHQLWSSLVVIAIGLYILWTQIGTSFVAAVIVTAICMIATPLLSRHIDDLQDAWSGVTDKRVRLISSILHQITGVKLSAYEPELVRKVEDVRRTELAAMKRFWTDFAVVVCVTNTAMNMLSLFTLGAYAIVSFLSGSGSLTTARLFTSYTVLTIIAAPLFSVGQNYGTVLAAYGSLKRIQSFLNAPERKDPHAVDLSITDKSDSPADEKPNELGFATGTLELRGTFGWGEKKVLESIDLQIPSGKFTAVVGRVGTGKTTLLASLLGETTAFGSISRTPIRNEIAFCSQVPWLRTSLSIEQNILFSSSMDRAWFNTVVHACALDIDFGANNLDSRLAKGLSGGQKARIALARAVYSRSTVVLLDDVFAALDGTTSAHVFEALFGASGLLNDRTVVMTTNKVSHLQHMDWIVMLGDNRVIEQDSYARLLSADGPTSALVKEHVQTSSGVMEAVQQVTNFDDSLEDVDKAEAEQEEIDAIQHGSNGFAAYLHYFAGAGYPSMLIYATFLVVTVGIQIVTPVYLQLWAAANDHSSGSASSILGRYLGGYAAVEVAYSIAFTTVFYFFIMSLVPRASTALHANAFKAVMATPVSFFGSTSIGKVISRFSQDVFIVDFEFPLAMHDFGYESTRMIGSAVLMIVSVPYLAIVVAFMLVLVYVIQKFYLATSRQLRRLDLSSKGPLYTLFSETVELNGLLTIRAAGKGVPYAAANSALLARSQMPFYLTNVSRLWLATNIGVMTAVINTCFVLIAVGNRSSTSAGLFAVGLSQAVSLQDIISLVLTSWTQLEIAAVAIERNLEYTKLAPEEDDHASSGNVDTDKLWPSHGTIEFDNVIASYEGQTEPTLKGITMTMAGGSNVGLCGRTGSGKSTMLLAILRALHVRGKITIDKVDTADVSHRTLRRNITVVPQEPLIIDGTIRENVDISGDKSDAEIWEAIEAAQLKDVIGGFDDKLDQSLSARGNELSKGQTQLLALARALLRKNKIVLLDEATGNLDVETDKAVQETIRAAFKEYTVVTVAHRIGTIVDYDQVAVLDAGRVVEIGKPSQLLENEESAFARLHNDSTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXM2</accession>
    <name>A0A4Q9PXM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Tetraspanin/Peripherin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_925205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXM2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXM2"/>
    <dbReference type="OMA" id="WINVHNI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25951" checksum="8EA035492E1DC370" modified="2019-07-31" version="1">MSKHFCCCIPVRAAVFFFSLLSFLASGLSAALAWYLLFLIDNNRLDEVEKNLNENDKQAFDAVAHKYKWGIIVGGLIFTLIALMSFFGFVGSIIRNRRMVKAYSFMTIFIFILGTVAAGFTLFATYNHKPICVTINNEQVCTQSHLSLGQKIGYTVYVVIEWLIELYIIVIIRRYYDQLEEEREYRHEFRLNPTTSGTYEAKEGLLTQGHYPYTDNHNAFGAHNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY62</accession>
    <name>A0A4Q9PY62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_925581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY62"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY62"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="58990" checksum="3DA96D89FE802902" modified="2019-07-31" version="1">MPTSSSSWRAAVCTYRDSPSSKYRNASTEGHTAKAAAAAPGVPTWEAAYGTHRFRQPEQWPGEGRRCLLRLRDARVQEEYRTFIQGKLDDYWKRYPLSSYANLGSEDADAARSRKENQENLLILLRKLREGLLSIKRKDAFALEVYETSLYLAVLFKSPVQTTSTLSHIFPDLYISIASQSAQPPASASASSATKPSRVISDREKSLSTSLRTEKGPEVSLPGSALATTLIFLLHHLVTTYPSQVAFHTQVRQLHPALQAVLGTPIFDPTSRLPAEAALSEPLAPPSISKLKLNVDTPSETGPHLGSKESKPKPAIEATTKTKTNPAAASGRQPPAAPSPLSNTASPSSRAPAAPRVSHPPRPASARDWLRELARCLRTRNYARLEGLTRREVFGGFIHVNFAELDTDTSGRGQLIEAIDPIDSKGGATPSYEDLALEAIGVLVESLLEKARGVTWNVLRTAYREVSLSATPSAPAHDTGTTGDWLGRSLVLRACAPRTTGPDGASVRHAALEAWLDERCRRGEARRKQGEGMDGRWILVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYL9</accession>
    <name>A0A4Q9PYL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clathrin-coated vesicle protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_923911</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PYL9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040108">
        <property type="entry name" value="Laa1/Sip1/HEATR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046837">
        <property type="entry name" value="Laa1/Sip1/HEATR5-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057981">
        <property type="entry name" value="TPR_LAA1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663:SF0">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21663">
        <property type="entry name" value="HYPOTHETICAL HEAT DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25468">
        <property type="entry name" value="HEAT_HEATR5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20210">
        <property type="entry name" value="Laa1_Sip1_HTR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25808">
        <property type="entry name" value="TPR_LAA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LAA1-like C-terminal TPR repeats" evidence="3">
        <location>
            <begin position="1809"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1990" mass="214464" checksum="BC5AD920D6FD65EC" modified="2019-07-31" version="1">MAASDSALELLDESKVSGENGEIYLFQWLSSTERLAKKATPEQLKVVQTDLEADMIKVITAPEPFPLPGRPVRRLVASCLKAFYMRGETKSLFDTIQAFLKLLAETKPPAKDSSRTAAMYCVGELMGTFGSQVMSLMAEVATVTIKLYRSSSPIILRAYSLYTLARALSTAKRAVADSVAKDIIKHSKNALSDKALPVQRAACEVLILMYPSGDGTRSVADVESVLSICVKSLEGADHLTRRALAKLAAHMLASTQVEKVIPVVDTAKKGKKTQKEDEDEDSTPGMHVAAEESKPVMTPTEMLQQLSTHFNKPQASRRTRVGIFDFYSALLSLLGSSFVESNYALIVTHFMTEIVSNPRNSGSRYEIIFVRSLVEVVLRDLIGVRMLGEQAQIAAIQELSNTYLKRWPALMPGSSAPSPLCLVIALREVSGLVQQLGNAPGPVQDALLDPLLNLLSHPSHSVRINTAWTLRCFCYSTPLRLPKVLISVVEKMQRDISALTTPAAPSDIHLRALGHAYGLAALLAVIPDRPLYVSYDISAKVFDMAVQVLKRAGEHDVKIAQVEIEIAWTCIASLMTLGPNFVRPHLPQLLVLWRNALPKPTMKDGAAGRSVAEWEFLLHVRESTVGAIYCFLKHNSPTLVSADVTRRISSLLSNGLAFANTFLTSRATLNQEELSADGKGFSIDRREALLRSRIFQSFSLLGFGGVTESVQSSLLQSVITLFASPDGYAGSSVQAAIASSAGTFTSIWQSMDGYAYGLTSLQVDDSPKDWMNRDSIEMAIDEMTQKPIMTALEHDPLYLCQALAVDTSRRVPEPPPAATAAVDAAVQLFAQLLPLQDVAQTTRVVTQLLGSAGSAKLEKNAGRKAAALVNTTFAVVLALRQATTNSARQVLGNAQVSSSLSTYLKDVVVDGDPVLRRASSEAIGRLASVAGTNFLTSQVKTLVDQVVSNRDPHGRAGCALAFGAIHAHVGGLAAGPLLKTTVHVLMSLINDPHPVVHFWALNALARVIDAASLAYAPFVPSTLGLLFKVYMMESHEPDGGSLNHVNISGDLPTYQVVCQNIDAVITVLGPDIQESTRTRTLVLDLVYQFIDEEDDGICVEAMKCIQHFLMFAPDHVNVPELVARFRGYLSSSRRPLKLASINALYQLVQRDALSMSKLGGDKLVEELFAMLDDDSSVDGVRNVIASWLQQTVIYNPSAWIDLCQRIMSRTTASQQAADAAVVDDEGQSLSVGTSSSAGRQTSRWRTQLFALQCLHSICAVVGQSGRREHLDIAFARSQGLPIHGLLVSRVPDLIKIAFTASAAHVTEIRLEGLTVLTDVIETFAKTPDPDYEENLLLEQHQAPITAALTPAFSSDSTPEILASAIGTCAIFVGCGVVKDIGRMGRILKLLTSALEQSKGSGMLTLGDAAELSPNASVMLRIATLSAWAELQVASAQQTYLVEVVKPHRAVLAPLWISSLRDYASIRIDAETLDDTPAGALDSSYSSLGREVLLPYYIRAWPIILNAVAIAMQNDDPSILAAMDGQDALPDGPPSDIQSGTREEPTTFFFVVFGLVYEALATSTPDSGLEAQRNSIVSLQALKCLVRRKYCGRVFNDQPLFEELLSLLYRMALTESSGVQIHLVEAIASLADSIKSVGTTNGHTGTDVLSSPQAHCLRVCAYILRRVISGPKTGAVHDAASPAEKVRLIIAAFEAFSAVAASFGPSYREDFRALAITLYCDLLKDESSELDFVGPTLPALKALLDRPANLPDPDHKYGRLVHGLLSACLVNIGAMSGREGPMCNKKIKCNLLAAVLILTVLPTTVAIGKAIIEHCCSIISQKLVEGSELSLTAAHCAKTLIMASTSGNPILRQCTRLLLPGLVECLAKAAASSDEASPPDRVMATVGEINKALSALLLSLSEELRPRALGVIMPVLVLFLDPSRQPPTPLHTQAVTQLLALAAASPAAFKDATGRLEQSMKETLETSVRQALGSKSQVAEPAKPQISLRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYS8</accession>
    <name>A0A4Q9PYS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_406533</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYS8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="387" mass="42415" checksum="922C6D4DF4EF6D68" modified="2019-07-31" version="1">MSRTFQPPPPPPPPQPANELGRYRLLSPSAGVRVSPLCLGAMSLGQAWSGMMGGGTTEEEAFKFLDTYWENGGNFIDTANSYQNQESEKLVGAWAKARGIRDQLVIATKYTIGYKNEDPEIKLKVNYQGNHRKSLVLSVEDSLKKLQTNYIDLLYLHLWDYSTSIPEIMQALDSLVKANKVLYLGISDTPAWIVVKANEYARAHGMAQFVVYQGLWSLATRDLEREILPMCRAEGMGIAPWGVLGQGKFKTEAEIKSRSTLRYNTPQTAEEKSVSAVLEKVANEVGNGVSLGAVAIAWALQKSPYVFPIVGGRNTQQLEEVIKALDIVLTPEQMKSLEEATPFVLGFPYLPLFGTDPALGDGRGNFFVSSAGTVKFVKAPAPIVPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYZ0</accession>
    <name>A0A4Q9PYZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_357293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYZ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYZ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="2">
        <location>
            <begin position="289"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="489" mass="51089" checksum="4C947B45383200CE" modified="2019-07-31" version="1">MIYLLANVSSLVNAKWYLGIPFNDTSNLRLQIAEAAEAILGDNVLAFQVGNEPDLYVAHGHRPSGYNQTSYFDEFGIVVNAISNNANIPTRGNLVAPSLQGTWTLESVFDTGFLTSYGSAVSILSVEQYPDNNCAAAFPDAGFGTPVNPQDVFANYLTHNAGKNLIAQYLSAVPTAQQMGKQFMMFETNTASCGGFPGVSDSFGSALWAVDYGLQMAYSNFTGALLHIGGQDVSYNPFTPPPTNLSTTHGWTVGPIFYSTLVLAEALGTTNTSQVLDLNANSGSDQTPAYAIYENGALARMVLVNFMTEQDGQGAYTATISVGGGQTGEGNGTPSQVKVKYLTAPSVAEKDNVTWANQTYGGRFECDGRLSGTEVIQTITCDTNANTCDIPVPAPGVALVFISSGAQGETDPSTTETYATTALTKTANTVSIDPSVLATSNGMSAKDRGLSSTSQGSSDAARTAGAVPGLVALLAFVLGACAVSGALRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ57</accession>
    <name>A0A4Q9PZ57_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_816956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ57"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5323" checksum="51CE0226D9389CEC" modified="2019-07-31" version="1" fragment="single">RSDPLGSDPGSSQGDINVGASGHVNRRVGRPSATHCSLLKLGLSVAAKPAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0S7</accession>
    <name>A0A4Q9Q0S7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">TATA-binding protein-associated factor mot1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Modifier of transcription 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_1037666</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q0S7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17999">
        <property type="entry name" value="DEXHc_Mot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000009">
        <property type="entry name" value="B-TFIID TATA-box-binding protein-associated factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000428">
        <property type="entry name" value="TATA-binding protein-associated factor 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044972">
        <property type="entry name" value="Mot1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044078">
        <property type="entry name" value="Mot1_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022707">
        <property type="entry name" value="Mot1_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36498:SF1">
        <property type="entry name" value="TATA-BINDING PROTEIN-ASSOCIATED FACTOR 172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12054">
        <property type="entry name" value="DUF3535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="310"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1088"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1895"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="310"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1094"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1895"/>
            <end position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00081329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU60629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1944" mass="214775" checksum="889621B84562A24B" modified="2019-07-31" version="1">MTSRLDRLLLLLDTGSSASVRITAAKQLAQLAAKSVISDVALVEDDVKTTRNHVLISDSSGWSELMAVVARILPYLHSRSHETRSAASTALSQIFSLVPLWKPCPDADTKPYGASAVLPPPEFPSFSVRELMEKGTLLLASSGKEFQKPTGILANSNEVKKARKEAMGRLGLDFLESVGGADDMDLDKELAADEPDTDVDMAAPVLLNTEEDAAPSSPTDDYVDVKVKKEDSVPVFGRSNSSTPQLAASPAPVTSAAEDTSALSARERNRLKRKRKPGNAAVVGALPPTQASGAKYQAMAAGGSKARLVARDEQPSSKQRLDSPKSPVEGPSQDRVVIDPTKGGAVAPKTESKSKALEVQPGTWVWDGLVKLLEVDLFSAAWEVRHGAAMALREVLKLQGKYGGTKVDLSWDENLIAHERWCNDLAIKFLCIFVLDRFGDFVSDQVVAPVRETVSQTLASLLLHMPRRSVLHVHNVLLQMIRQDFPIPVKPTNGKSFNKHNDKSHVWEVRHAGLLGIKYEVAVRSDLVSLDVPEGDCMEVDDGKEVLRGVVDAAVLGLGDRDDDVRSVAASCLLPVAAYLVERLPEELSRVLAVLWSCLSDMKDDLSSSVGAVMDLLGQLVTKNRVIEIIADESRSHPITVLAPTLFPFFRHTIANVRLAVVKTLHTFMTVESLPRGWISVPFLRLLFQNLVVEERSDIRDATLTTWREVLSILSQTSGWLESSIAQPLLLEWYGVLMTPLGLALDATSFYDPNLSDNSAPTERHNVDKNMLAQDLSLVPVEVVMQARLAASAALAHIIAFWPSSPAPGSLSVDDTFRPILTHYIDSTSMLQKFLAAIIAECWAREYDIRAPPDSALLIEVSPLAAELSQKTLAFLQADPPAAYHEMAFTLARIHGECHNLLQSFMFDCKLPASAIPSLGTEIDVTGTKPECFTIETAQAAVGPMFDKLKDSLGRTKKRELAIIKDKRLKVVSSIERYIEVKAQYDVRVAAAFAAAFVAFKSTPDKVSPIVKGIMNSVKNEENLDLQTHSAAAVAAFVEFCVNRVLTQPPEKIVKNLCTFLCQDVDQTPTFLHNRKTLHGVLSFNKQASAPQNGRDHANPTEDPAKAKLSRRGARLAFEKLSAKFGPKLLDAIPRMWPAMAGGLMSACSGDSVSAMDEKIEKREGQNVIDSLSVLEAVVPTFHEDLSYHFVQLFPHVTLALRSRFAIVRQSAARCFATICDVLTLDAMRYVIEKVVPFLGDASTLANRQGAVELIYHIVQKLDIKALPYVIFMVVPVLGRMSDPDDDVRATATNTFASLVKMVPLEAGLPDPPNFPEDLLKRREEERQFLMQLLDGSKVEQYNIPVTIKAELRKYQQEGVNWLAFLAKYQLHGILCDDMGLGKTLQSICILASKHHERAQKYKETKSPDSKHLPSLIVCPPTLTGHWYYEILKYTENLKPVLYTGNSRERYKLLGKLKTYDVVVTSYEVVRNDISSLQDINWHYCILDEGHIIKNAKTKLTKAVKQVKAVHRLILSGTPIQNNVLELWSLFDFLMPGFLGTEGSFNERFSKPILSNRDGKAKTGEAAALALEALHKQVLPFLLRRLKEDVLNDLPPKIIQDYYCELSELQKFLYDDFSKSRAKIQAEDVVRSNKEKDGEQTHVFQSLQYLRKLCNHPALVFKNDKEAIKDALTKSAINASSGDLSDIQHAPKLQALRQLLLDCGIGLAPSATGDTTKSELLDTEETATGAFSQHRVLIFCQMKQMLDIIETDLFKQHMPSVTYMRLDGSTDAKKRHAVVQTFNSDPSIDCLLLTTHVGGLGLTLTGADTVIFVEHDWNPMKDLQAMDRAHRIGQKKVVNVYRLITKGTLEEKIMGLQRFKLNIANSIVTQQNSGLASMDTDLVLDLFKRTTEEEDAAAAKKKDKDASGAPPGQRNVLRGLEDLPPEEEYQELDLKSFMGSIGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1T1</accession>
    <name>A0A4Q9Q1T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_874285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1T1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7634" checksum="13B6F5190C51D609" modified="2019-07-31" version="1">MSARQSSRGPRDVCPAVPSTASVRTCLPRFYSASRSSECHRSPIRPSKPQSTASLCDLEKARGSLSTVARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1W9</accession>
    <name>A0A4Q9Q1W9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_813583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1W9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1W9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="576" mass="61176" checksum="1BE97CBCDBFB18CE" modified="2019-07-31" version="1">MRVKVESVAPLPHLKAWFTLNAIPTVHDLKTALCIDLLPFRDAAVHAQQLTLLLDDFELLDSSPIDVVRDGDLIVIKKAPAPAAHKRKAAAQGEHANSPARKRSKTNDGRALSKPPAVPPSRARPKRHTPPASSSESSSESGTDSSGSESSSSDSDSSSDSESDSSTSSDSSSSSTSSSAPSVHLPRRRSSTRTANGVQTGPKEQVTAPKPAPGTPPVPPGQGKPSTHSRNLRRRRKKLYERIALTAEPASVNEIPLGTRARTLEPPATAISTPSEEPESQQSKPAKSKGKGKAREGSGDAEPPTFMMASLSNKNKRRGFKDALIRGVPAKITFTDGVSVPSTSSAGQVDAAAMQVDADADALVVAASLQAQETPRRTQQPRLVPPSEKQERGLLPPNMFVTSVDVEEGMWLSRRKNKKKKQKQPIEEPWDQEADATFAGGLPYDGECAQAAYPASNNANGAGTNSDSGEATERAVVAARWDSLRKITDKSQVSVGATVAWKALGINFATLTPEMLLHIARVLQCGDQLIVQPISEAGTGGVSFGGVVVEEEGGATEETFEWADVFQGDWRLVVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q348</accession>
    <name>A0A4Q9Q348_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_176858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q348"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18289" checksum="03671653BBE291D8" modified="2019-07-31" version="1">MAPIRHIRRCSDLRENRSLVSASRNGGRGDGDGRTDGRAASVCPAQPDGTGLEGAEADLEPFACFAGPASLARIPRVLGFVRDRDCGTRSVGTAKERPRGRREEGDLKGADISGTRSVRRCVCTPYRRLPLPKAGGTHASCKCCRSPCLNREDEDGHNVRRSAAGPQFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3N2</accession>
    <name>A0A4Q9Q3N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3N2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020740745" evidence="1">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="226" mass="23446" checksum="22AC007484EA0A45" modified="2019-07-31" version="1">MKRAAVFASCAGLALCANASSLQLAACEATRPPCSWTGNNVNASAASLVTVHIRDLFSAAASQSDVVHCCAFYSPPSPCLLPSLKPAAAWGDSDTDTAPLETLDVFDLDQSPPSSPAMQFSLLAISDRRDRASYDAGICLPRPAAAPAMLEHLLPSGPSMSARAGKRALRRASALTSVATRVSADFALGSPDAGSSFFGALYDSYSLWELASVFSAIAWLLVCLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q474</accession>
    <name>A0A4Q9Q474_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_919363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q474"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q474"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19490">
        <property type="entry name" value="XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="397" mass="44054" checksum="1A9AE8A4735FDB5D" modified="2019-07-31" version="1">MHCELSASDILAEIQTESLQTFLTSVRHETSSAGSTYIPALDRHLSTANVSRTSHGWPLNRGDVIEVQGPAASGKTQFLCHMLLTCLMPSQHQGIHLGGWSKAAILFDTDGKFSTSRLHELLVSRLSRLLGRDSPHYTNVTIDLEDLATRCLENLHIFRPTSSAQLAITLIHLPNYHATNSRLQTTEIGILAIDSLSAFYWRDRYSLEQLRDATDGSSHATLPPNPLYYVVKALQEFRASHRPVILLSNWGLNAFSKPSAPGEPESPFYRQHLHPFPAPFEAHGAAEAISNIQNSQRERSASVDPSRDSPAGPARRQADVTRLPLHYHITLHPAPIDPFPASYALAEAIAQEHMRAALVNKGEIRGLLRTPGSSDVREFAFRIGDREIFVHEPERTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4G1</accession>
    <name>A0A4Q9Q4G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_121634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4G1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="242" mass="25668" checksum="04C4B7E76E393BFB" modified="2019-07-31" version="1">MRLRTARLARAGRHGEAWVTLDADLTVISGPSRSSTPDPVRPSTLLRGLRPPTTCYSSLTRLLRPVCPSCSGCARASSHPPVAGVRTVTSSDAGLVSCSGEWWCSAVSAACACLQASLACLRSRARWRSRPRYIVVKRSGRTCVASSMPPPMPRICHPTLVRASVALAEDRRALARAALGFAVAPAPCSPLSRLCLSPRVAVASFRLAPRCFLSSLHGCACRLPAYPLAPLSDPALRVVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4X5</accession>
    <name>A0A4Q9Q4X5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_49524</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4X5"/>
    <dbReference type="OMA" id="INVLPCD"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020631529" description="laccase" evidence="14">
        <location>
            <begin position="24"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="33"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="166"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="368"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU62433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="530" mass="57263" checksum="31CE70C7C080B6A6" modified="2019-07-31" version="1">MGLSRSVWSLAALGLLYARFVAGAVGPKGNLNISNADISPDGFTRAAVVVNGQFPGPLVSGNMGDNFQLDVIDSLENTTMLTATSIHWHGLFQMGTNWADGPAMVNQCPISKGNSFLYDFTATGQAGTFWYHSHLSTQYCDGLRGPLVVYDPNDPHSNLYDYDNETTIITLADWYHTAARLGPRFPTGPDSVLINGLGRFAGGNSSELAVVNVTQGSRYRFRLVSISCDPNFTFSIDSHNMSIIEVDGVNHRPLVVDSIQIFAGQRYSFVLTADQDVHNYWIRAQPNIGTTTFDGGVNSAILRYTGAAKIEPSTNQTTSVLALNETDLIPLQDLSAPGTAEVDGVDLALNLDFSFNGTEFFIDGVPFVPPSTPVLLQILSGTTSASKLLPNGSVYSLPSNSTIQISFPLNTTATPGGPHPFHLHGHKFWVVRSAGSSTYNYDNPVQRDVVSTGANGDNVTIRFNTDNPGPWFLHCHIDFHLEAGFAIVLAEDTPDVANTTTPSTAWENLCPTYTATYPSGISKRRSLPDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5N7</accession>
    <name>A0A4Q9Q5N7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_919170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5N7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6053" checksum="CF52002D74820F66" modified="2019-07-31" version="1">MAYQMGSASSLLHRGLHKSSCQNSPSNPSGSYRAPKTGYNSSNCHYFGWAGLGSSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6H7</accession>
    <name>A0A4Q9Q6H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_810060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6H7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6253" checksum="8F76C0AE8C70CAE2" modified="2019-07-31" version="1" fragment="single">AFHDVTNGANRGCQTAGFVAAPGWDPVTGWTRPTFLYCWLLSCPYLECCCDPISSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q749</accession>
    <name>A0A4Q9Q749_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_917261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q749"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q749"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="168"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="412" mass="44380" checksum="A7CA5904B49B9024" modified="2019-07-31" version="1">MPSDSSTHPRIVIVGGGLGGLALLLTLHRRGVPATLYERDTSSSTRAHLGAPLDLGWESGQRALRENGLQVNFEESADSEGRRIYDGAGTLHFSHGAGAQGGSGRPEGPPPPQRPEDSRPEIERAVLRKLLLDAIPPHLIKWDHALVSVRSLGHGQHELTFANGFTTVSDILVGADGANSRVRPLLSPATPIYTDVKFIDISLAPETTKLPELQGTVASIGKWTLLVMQNSRMLGSRMCGDGRIRTFAAIRESADWTLPSDPAEAKAVTKTYFAGWQQWMLNLIDYADESAIYIHALYVLPAGHSWPHVRGVTLIGDAAHLMSPFAGAGANLALLDGLELGLALAGLATEGKLADQEAVDEAVVAFEENMCSRAGRIAKQAEDNLHEFIHPDAPHPAIRRFKQVFAEGRHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7U9</accession>
    <name>A0A4Q9Q7U9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nudix hydrolase 20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_916788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7U9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7U9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="374" mass="41883" checksum="D908BA4A4D936C53" modified="2019-07-31" version="1">MPPPTPTAPQSFLHILANCDNFRLPPPTAQSTEPLVPWLLFPSPTSPAVGLLRPEIVAQLRSENASSPSPSWHFSDPALEQGTSARGWVSFARGIDTPAARSRVMKELCERWRDTGLWPDEVGPRKWRAELYPVYRDPFGPRDYPSEEWVADGEGDALNYAFEMERAASGLFGIVTYGIHMTVYEDVRAADGTVVDYNVWVPRRAATKQTWPGYLDNSVAGGIEAGMKVFDCVVKESMEEASIPADVVRRHAKAAGSVSYFFRTPRGWLQPEIEYVYDLCLPPGSGVKPEPLDGEVESFELLPLSVVIEHIRTGLFKYNCATVLIDFMVRKGIITPDNEPDYQEIVTRLHGRFDHDRWTSGLQQCATWTRRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7V1</accession>
    <name>A0A4Q9Q7V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_917789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="666"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="716"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="922" mass="100042" checksum="B0D3662E3AF7FC89" modified="2019-07-31" version="1">MTTSHTGGRQRAERAALDAPLLDAAARADESGVNAALARGADVNAVDGATGNTAITYAIAGESGWEDVDVSDASFMLQSRVQVLRMLLRSETVSLYALNAPARDVTPLGLAAWLNVPDAIRVLLEESRGLVAVDGTDSLGVTPLMYTARDGAVEAASILLANGARPDLRDTHHRTAVHHALRHPRMLWLCESTLRKQRLREYFNGNRRQLQPLPQPYVAYAQTSATSPVDLTHWPAPSEVVLSRSTEALIRAVAGSDLTAIYQVLFPASHRTTVLVNRLDSQGWGPLHYCVTSQAPSMEVLDALFLAGADTSLYTSSNHGTPLHCLVRNAQAPLGSLQAARLHVFIRHFIRELRAPLAATDEDGETCLHVAAEHGKSVEVLLALLACDVRHTVREMRNARGLTPLEVAQPEFRSAFGPEAEPRRSNSAASFRTIRPSTSSSTSTSSSATAMTVASPRPQLGSGSKPELPADDVDASLLPRRILDNLTAVGQEALSADPLQLSGLQDVLDETSHLGETWVHSMHSRIQEAASDLRDARGKFNEVDALLESVTCELEEAFGEDLAGHRDSTERARRRTTDSADSDKTAVSSRTSSSLSRKWRSMSDLRCSVDGNRREHPAERAKPPYLTIEEEEESAAPIDRSTTEKSFLNALLPPTAKELLHKSSKLSVDSGRTVSPAPHKKDGSPSGTSKLKAWFRKKLRFEIPDVSNETRIVLPGEQSPQRSPCQTQRRVPSPTEDALRTARRILRTAGKDLSCIEGCMDDAEEFLSLAANLLSQTERRLKLIIVSRQAALESARLAQLEEHLDDPFMSAIASTVRAAHSDAAIPFPLTSRARAGSGSSGSLLSSISAGSSVVSLSSTLIDAEDDDTRVLRRLMTRKVEARTDGALDEIDKTLTWLRIVQDTLRSLRRRTQTSATATGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q802</accession>
    <name>A0A4Q9Q802_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">26S proteasome regulatory subunit RPN2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_1035412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q802"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q802"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000017">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="7">
        <location>
            <begin position="758"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="811"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="961" mass="103482" checksum="A261FF21CE203B96" modified="2019-07-31" version="1" fragment="single">MGVPLQSSAAGVLALLSDPEPQLKHYALKALNQLVPQFWAEISEHIALIESLYESDDLPQEAHDSAALLASKVYYYLGEYDESLSFALGAGSAFENDPRGPGSEEYVETIVSKAIDRYISSRNAEQTEGKIDSNLQEIIEGIFRRCIADGEYRQAIGIALESRRLDIIKSVYEQTRDTTLLSYAMEAVLDTAFPLAYRDQVLKFLFPLFPAPTADAKSTHVYALTRILVTLNSPELTINFLNSLVPKQKLLAYQFAFDLVEGGGQDFLVAVRKDLPEGNEETKPIYDQLKKILLGQESIKLYLEFLKRNNKVDMLILKNTKEALEPRSSIYHTALTLQNAFMHAGTTSDVFLRDNLEWLALANNWSKFSAAAAIGVIHKGHFQESMNILGPYLPAQGAESSIGSAAYSEGGALYALGLVNAGCGSGQEVENYLRNLLKNSVSEVVQHGAALGLGVAGMGGKSMEAYDDLKTTLFTDSAVAGEAAGYAMGLIMLGTADKTSADEMLTYARETQHEKIIRGLAIGLALIFYGRQEEADDMVKLLMAEKDPILRYGGVYTLALAYAGTSNNSAIRQLLHVAVSDTSDDVRRAAVTSLAFLLFKTPAQVPRIVQLLSESYNPHVRCGATLALGIACAGTGLQDAVDILEPMTRDSVDFVRQGALIALGMILVEQSEASTPSLAPTRALYAKIVSDKHDDPMARFGAALGQGLIDAGGRNVTISLQSRAGSRNTAAIVGMVLFCQFWYWYPLAHCACLAFEPTGIIGLDESLKAPKLEFSSNAKPSLFAYPAATKPPKKETVAKVATAVLSTTAKAKAREKRKAAEAGEPVSEDKKDGDVEMKSAEASTSRHGDVSPISLAEGASRGRKGEPSSEKLSNFSRVVPAQLAYITFPTESRYQPVRVISTRPPPGPKAPKTASSVALASERYAGGGGILILADTRPDEEPDYIEFETAPAAPAAAAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8Z6</accession>
    <name>A0A4Q9Q8Z6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Pectinesterase</fullName>
            <ecNumber evidence="3 7">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_944781</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pectinesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="3 7"/>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8Z6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8Z6"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033930" description="Pectinesterase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="303" mass="31745" checksum="F590F0872045A0C1" modified="2019-07-31" version="1">MRSTLALVLSYLVVSALALSSPPAGAITVGSGGQYATLSAALKDTSSLVYFIHSGTYTDTAIITRANVRVYGQTNTPSSYSGNTVTITNNIPASQAGSNDASGTVQVHATNVSLYNLNIANTFGKAQAIALSVQAGEFGAYGLKITGDQDTLLANVGTQYYANSWIEGAVDFIFGMQASIWITRSVINTIGNGFITASGRSSDDANWYVINNSTIQGTGPAFLGRPWRDFARVVFQNSVLGSNVPSAGWSVWETETDHVTFAEFGNTGAGSSGARANFSTKLSAPVSITTVLNSTSWIDPAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q942</accession>
    <name>A0A4Q9Q942_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED18</name>
        <name evidence="10" type="ORF">BD310DRAFT_868002</name>
        <name evidence="9" type="ORF">BD311DRAFT_713916</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q942"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q942"/>
    <dbReference type="OrthoDB" id="10018982at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13321">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU32878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22987" checksum="BF11A65A15F1D83B" modified="2019-07-31" version="1">MSTSHAYEVALFGEFFSQDLAAVLNRLTLHSESAHQMHAREIVFEPFDAQSQRDAGSEPILLRARKELLDPESKWMMYSYLKPESVRVHPEATVRPWATCQIVGDALTFASALGYVRRSQIYKRGYVFRRGNLVVQMFQQENSDLKTGKPIPAHVDTLWEVEVKTAAPVRNSQETPLSQSLDAVLEVQLLMKGLLDLRRQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q986</accession>
    <name>A0A4Q9Q986_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="20">ATP-dependent metallopeptidase Hfl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_1017582</name>
        <name evidence="19" type="ORF">BD311DRAFT_682554</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
            <strain evidence="19">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q986"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q986"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000003">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1690.20:FF:000003">
        <property type="entry name" value="Mitochondrial inner membrane AAA protease Yta12, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="337"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="759"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="97"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="759"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU34599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU63626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="804" mass="87963" checksum="12F4C7696B92ED09" modified="2019-07-31" version="1">MISRSLRARAAVLTRRRAAPALVPARFSRFYATPSDSQPTPDQKPPADSKSPEESAKDKEGQVENKQAEGKDAQPKEEPLKGLEGFFQRYHQQQQAAKRESTHQKDGGNEHSQGRQEGRRNKQENPNANNPFNPNQLALLATTAAIFFALSSSSYPSAREITWQEFRTAFLDKGLVDSLTVVNRSKVRVKLHSNATGTMYPTAPSGGGEYYFSIGSVEAFERKLDEAQNELGIPSHERIPVSYHEEVSTFNYLVSFGPTLLFAGIMIWLSRRAGGGAGGGGGIFSVGKSKARMFNNETDVRVRFADIAGMDEAKVEIMEFVSFLKEPARYERLGAKIPRGAILSGPPGTGKTLLAKATAGEAGVPFYSVSGSEFVELFVGVGSSRVRDLFATAKKNAPSIIFIDEIDAIGKSRGKGKGIGGNDEREQTLNQLLVEMDGFGTQEHVVVLAGTNRPDVLDSALMRPGRFDRHITIDRPDVVGRKGIFMVHLKPLRLASTLPEVGKFAEKLAVLTPGFSGADVANVCNEAALHAARVGHDSVTEDDFEAAIERVIVGLERKSRLLSPEEKKTVAYHEAGHAICGWFLEHADPLLKVSIIPRGVGALGYAKYLPPDRYLLSTPQMLDRICMTLGGRVSEEIFFGHENVTTGAQDDLQKITRIAFEAVANYGMNDVVGPVSYGGANATQESLVKPFSEKTAEMLDEQVRKMIVHAHRRTTELLTEHKDDVEKVAKLLLEKEVITREDMIALLGPRPFANRKDAMDKWLEENSQERSAPPPLETVEPTVAPEDPSPTPAPAAKRIDDAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9A1</accession>
    <name>A0A4Q9Q9A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_868422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9A1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="18026" checksum="22C69B694C0EAF86" modified="2019-07-31" version="1">MAPFNSNLSLPLHPPASTTSNDEEDYDVYLFYPSRNQIYQRARQSSWEPSWDEGLWSSSDVSDVRLFFVASSQPATYVQCQPSSPTYSYDSDFVYPNPADEHGISVFGYSSLFRRGLWAQSRRISRRFDDFVAKIINAWRCLKMRFGRRAHSTSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBJ0</accession>
    <name>A0A4Q9QBJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_402165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBJ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23188" checksum="73F68E510EE62288" modified="2019-07-31" version="1">MAWRYKRARGRVECRQRGLREGMGGLTAATQPRRGREGTAERRRREGGRREKGGRAEIRASLWGGPGAAHGLRLPRSHACLLLGFPISPIIIPDSCHGLFAVRCTPFQYHQSHLSIHPPSLFPSACSQAHVPPLSPLVLHPRFLFPLLPRPHPHPPPDARDCHGPVDVLARAPRLPTARPHWAHLASVHALRTDVLPASCERAAHGGPRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBQ3</accession>
    <name>A0A4Q9QBQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HD-domain/PDEase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_805830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBQ3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBQ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008832">
        <property type="term" value="F:dGTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006203">
        <property type="term" value="P:dGTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050135">
        <property type="entry name" value="dGTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11373:SF4">
        <property type="entry name" value="DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="523"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="665" mass="74826" checksum="4D44CE72B08BE6F4" modified="2019-07-31" version="1">MASPGLQTHTQKRMLLELDDDWAAAAFEGQTSVRRFKDSIHDYLPFGQTICAIVDTPQFQRLRNIKQLGTSYYVWPGASHNRFEHCLGVAYLAQTLAMHLRNSQPSLGITQRDVQCVTIAGLCHDLGHGPWSHVWDSLFIPTILPEKTWCHEDASRMMFDALLEENGLELHEDDATFVKALIMGTPSMCKKKEKPYLFQIVANKTNGLDVDKFDYIARDSHAIDQTSNLSLTRLIYSSRVIDDDICYDIKDANQVFELCHTRMSLHKRIYTHKTGELCFQFGGCRPVADLGHVAKAIEYMIVDALKLAEPVMNIARRLEDPKKYLHLTDHIQTEIEASEDPRLEEAQKILHRIKVRDLYKTVDNKVFPWDQKADLKAMFTPESVVKAFKELYAGNPTLDSSEQLDGLDNDPEKVKVLAEELSPEHVIIDLTERHHGMKDENPLHFMKFYSKHHPDKGIYANEDNISVTLPRAFGELLLRVYTRESRFFGVVQRGYRKVLKAFSEMQERKAASSGLFLDDSGNPLDADVDLADPPVHPVTPPAEAPTTPKLKPQQPRTMSRVPTRTLSRHPSGVVDGGVAMTPIQDNPFTGVGATYNPKDSPAKKGKKRQRETEAGKEKDAIKEKQKVDKADEGLDLALEFDPELSAPGGSAKKGGGSPPRKKSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBU3</accession>
    <name>A0A4Q9QBU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_305289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBU3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19604" checksum="4B2AE9B2712A8A73" modified="2019-07-31" version="1">MASVTRRSEYHSFVVVSLLGNRHHTSVAKRTVNPTYSPKDATFDFPIHLSLADKLGVVELVVWDKDVLKKDYLGEAWIPLEDWFRDGSAYAFDDMNNKLISRNLVSTRNSTQATGNIQVKLGFVPPANTATLMDFGEIYSELVKRTRPSLVSAPPVRSHYLPHACMRGARARPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBX4</accession>
    <name>A0A4Q9QBX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homoserine kinase</fullName>
            <ecNumber evidence="3">2.7.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_913081</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-homoserine + ATP = O-phospho-L-homoserine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.39"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13986"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. Homoserine kinase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.39" evidence="3"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBX4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBX4"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00064"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004413">
        <property type="term" value="F:homoserine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00384">
        <property type="entry name" value="Homoser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000870">
        <property type="entry name" value="Homoserine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00191">
        <property type="entry name" value="thrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861:SF1">
        <property type="entry name" value="HOMOSERINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20861">
        <property type="entry name" value="HOMOSERINE/4-DIPHOSPHOCYTIDYL-2-C-METHYL-D-ERYTHRITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000676">
        <property type="entry name" value="Homoser_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00958">
        <property type="entry name" value="HOMSERKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="12">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="356" mass="37878" checksum="3649F123E9E9035C" modified="2019-07-31" version="1">MTELNSPRSFTIRVPATSANIGPGFDVVGLSLSLHLTLTVTITPAHAPVPPQITHSGEGADEVPLDAYKNLTTRVALYVLRCHGIPTFPSALAIHCANEIPFGRGLGSSGAAVVAGVLLGNELGRLHLTRERMLDFALMVERHPDNVTAALVGGFVGSYLRELDAAATEAASVPLSEVLPEYPPDAGEGWGMDPPQPPLGIGHYVRFGWSGSIKALAIIPRFELSTAKARSVLPEQYSRKDLVFNLQRLAVLTTALAQTPPDPELIYEAMKDRVHQPYRKTLIPGLPEVTNNITPSTHPGLLGICLSGAGPTILALATGGFEAIAEDARTIFKGHGIEVDWKVLEVVGGSVVQHNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBY0</accession>
    <name>A0A4Q9QBY0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endoribonuclease YSH1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endoribonuclease ysh1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">mRNA 3'-end-processing protein YSH1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_914924</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBY0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBY0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="599"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="723"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="750"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="776"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00075008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="812" mass="89318" checksum="868435ADC4AAFA94" modified="2019-07-31" version="1">MSDVPKLRITLLGAGQEVGRSCCVIQYRGRTIVCDAGVHPAYSGIASLPFIDDLDWSTVDVLLITHFHLDHAAALTYIMEKTNFRDGKGKVYMTHPTKALHKFMMQDFVRMSTSSADTLFTPLEMSMSLASIIPVSAHQVITPCPGVTFTPYHAGHVLGACMFLIDIAGLKILYTGDYSREEDRHLVKAEIPPIHPDVLIVESTYGVQSHEPRDDKEARFTNLVHSIIRRGGHVLLPTFALGRAQELLLILDEYWAKHPDLHNVPIYYASSLARKCMAVYQTYIHTMNSNVRTRFAKRDNPFVFKHITNVPGTRGWERKIAEGPPCVVLASPGFMNSGPSRELLELWASDSKNGCIVTGYSVEGTMARDILNEPSEIVGMKGNTIQRKLSVDYISFSAHVDYSQNSEFMELVKPQHIVLVHGEATGMGRLKAAMQDRYKSRDEEIKIHTPRNLETLELTFRSERVAKAIGTLAAHPPQPNDVISGLLVSKDYSYTLLDPRDLRDFAGLTTCVVTQRQKVALGVGWDLVRWHLEGMFGQIEEGLDKDGIQTMRVMGAVDVKLSGEQELTLEWDSSASNDMIADATLALISGIDKSPASVKLTTHAHSHSHPPEHRHPHADITDESAPVTRIQRLCWFLEAHFGDVELHMPEEDDAEQSEDAPEPSLLVTLDEADAVINLLSMTVTSSSEALRRRVEAVLDMAVSTVSSLSEAFTAGVPLQVEEAAQGESGGKDKSSSSSGLPAIPEDREENPEKDVSMEDAEKPEVNGADTEVPQADGEDGAAGDGDDGDDGDDGDDGEDEEEEDDAILQVHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD34</accession>
    <name>A0A4Q9QD34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_971786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD34"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD34"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02178">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15093" checksum="7ADD9844788280CD" modified="2019-07-31" version="1">MSDSPEDARAASEDAKVDEIDDSGEPEASQQDPAPKRKRGRPPGSKNKKTIAAEAAKSTAGSSTDAPRRPRGRPPKRKAEEEKKPDEGSGEPSEAPPKKKRGRPRKNPLPAERTGGDGGGADPAAEPSQPKRKRGRPRKDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDP4</accession>
    <name>A0A4Q9QDP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_942887</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDP4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDP4"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045048">
        <property type="entry name" value="FBXO31/39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706">
        <property type="entry name" value="F-BOX FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10706:SF130">
        <property type="entry name" value="F-BOX ONLY PROTEIN 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12014">
        <property type="entry name" value="Cyclin_D1_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="5"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="451" mass="51455" checksum="9253D6591A96410D" modified="2019-07-31" version="1">MATAASPFLDLPYDVLQCVFAHISAVDILSVISTSKRLYYTLMDDNATWRRFCAAYGVTDTSVFLGRSFRLIYGRLFHRYGHLLGLWCSDYPFKGNIIEFRLLPDHWLRMGEPTIVGDVWKFSTEAGNPRPHYPTYTEFIQIGFTPRKKITQKTANDVHVSWHLRSDCDLGFLVHNGIPPPWVRMDGDRRMGTPSLRVIAPSKMTLELADFFRHPLHSPEFPESTSTPWYDAKRGVPRLRQEGPPPIIPTQRRWFYPGDVHYVEGTPKPASIAIFPPPSDEPSEVHLPDLHNTMHPLSSPYSVIVPRYYPLRTVMQEGEDPASQNWRPESLVGLWLGDYGPHGTECLFLEHNVADSMIRAWKITGDVNVPRGACTWHAFLQQEAHWTDSSGLGMRAYMGEGRIARHGFIESSLISARVIINGKDEIMVAWDLLFTAKFIRYKTARGRTGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDR3</accession>
    <name>A0A4Q9QDR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_912175</name>
        <name evidence="2" type="ORF">BD310DRAFT_912211</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDR3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7234" checksum="3F744259AB3EF28F" modified="2019-07-31" version="1" fragment="single">MFHSIQRLTNRLGQITTVLKSSYASSGSRSSMDEDIYRWLLYGTILGLHNSTLLPAPVRRHSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDR6</accession>
    <name>A0A4Q9QDR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Muts domain V-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_913607</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDR6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDR6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="9">
        <location>
            <begin position="932"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="671"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1076" mass="118841" checksum="BCD0A6F8A4996EC5" modified="2019-07-31" version="1">MLSTSSSSIACCARRTVYSHIARCISTGLPLAEEATQPRRKPRVIKKEYAELPTGRVLADGTMSRPLGEWIGGLGEPIVAYGNVSSSILGEPSQLSSDEAACVIEGSDAPFSEESSIAPAKKVRRRRVKSSLPEADQTTEDGVESVPSPRARRGKSAKRTADDAEVPPPSSPLAMEILENLNRYPHCILLTRVGQFYESYFDQAAEVSRLLNIKLTKKTWGGQRVPMCGFPIMYLHKYLKILVQDHKRFVAICEEFRRDRPLDAKGAFERRVTRIVTPGTLIDEPFLNPYENNFLLAVAPAEPERLEESSSPSCTSETPVGLAWIDVSTGEFYTKNTTLGGLRDEVVRISPKEVILDERLRDDNTSPVRTAAVEENCFVSYISPSKLSNVLQRLPPSADQPNADDLLAQIDASKEVFPAALTGEEVAAIELLTAFMHAHLMEHMPSLMSPHRELSSSRMQIDSHTVKALEIRQSLREGGTTGSLLHVIKRTATSSGTRLLARWLCSPSTSVVEINVRQSLVAFFHSRPFLRQDLVLLLREAEDATRIAQKFLLGRGSFPDLTAICTTIDTWSSIKERILMEKKMDERTDDTVGDAKWSSIEKLMEKLVDLEWLAARIRTALVPREMTPMPDKEFSSDELSTSSVTPVPGRDFRNPLGITDWTIKPEFSEQFGDLHATLQSLLAEKDELERRLQVSYAAPTLTLRASPGLGMHIHVARKAHASQLRKDADFISVSESGSTCTFFHIGWSQLAAQISETTMAIAVAEKEAFEVLRNEVISQSTSLRRNARIIDELDVTLAFANLAVEMHFVRPTVTENTSYHVVNGRHPTVELGLLTSGRGFTPNTVTFTPDSQLQIITGPNMAGKSTLLRQTALIAILAQIGSYVPADSAEIGIVDRVFSRVGAKDDLFRDRSTFMVEMLEASDILRRATPNSLVIMDEVGRGTTVEDGLAIAFATAHHLLSVNGCRAMFATHFHELADMLGYDAESHHGHGAFSKVAFFCTDVDEIEDGFFAYSHRVKPGVNRDSHGLKVAQLAGMPESAVEVARSALAWLKKRSAERADSKLDLRTLGQVLVSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDW9</accession>
    <name>A0A4Q9QDW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_972453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDW9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="256" mass="28477" checksum="1688198A92F88436" modified="2019-07-31" version="1">MPEVIDLVSGSESDADSSADSEVQFAGYHRDVNKSTQHATTLEEDGYVYAGFKALPQPKIPKSIVKRKKPEVISLLDSDDEEPQHKSQAELQRDLEREEEEDYVTTLAALDLDDDANWGNRLNLQKAYLEVNDEGDAHVELALSAAATAVDKKISERAFRRLAELPQDYFDLELSPERTYKTPHVYQQMPPPIFLAAPTFNIHKSSSITNVIGARRFQSITGHPSTGHLVANKTIHYAGGGWTLLPFGSVQQAGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K313</accession>
    <name>A0A4V2K313_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_826627</name>
        <name evidence="2" type="ORF">BD311DRAFT_779004</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143433">
        <property type="protein sequence ID" value="TBU27378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K313"/>
    <dbReference type="OMA" id="AFLQDQW"/>
    <dbReference type="OrthoDB" id="2737573at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU27378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19705" checksum="E79182F66C4D2330" modified="2019-07-31" version="1">MSITPKPEPEDTPLPPRPAPDAKAKQAALKAHAEYRRAQAWAIARWPLEKRVVPRRARVHLPRTYLARHGSDVRVVHAGADLNQFVHGHYCEEVDAARGARKLAAGDAEGVLARRHEYLGPDPRVVGYWVDAEGDYHVKFYDTFLGDQWMDDRKWKFDVRMDEDGKWVDVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4U9</accession>
    <name>A0A4V2K4U9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_309147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4U9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9480" checksum="97C725F571B46FC0" modified="2019-07-31" version="1">MPRRSGRNSGGGGCFWRSRESLLAMQTLFRTLLLAARLLCGSGKHPTASTCAAAFTHCPFRMRLWDYETLATAAFNDPKLQISGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5M3</accession>
    <name>A0A4V2K5M3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_820318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5M3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="22377" checksum="DC97027F7AD62EC5" modified="2019-07-31" version="1">MKFAVAFAAFSAVAANAASLGKRQSSACYGAVKGMVAYERPFVYPLFEECNYALGTEQAKQNPWTNKICVAAAVVASMPVLHDGLECSADPDNSTSIVLPPISQWPSLDYNVYADIVGECAWAPDGCPITQQNFIDLVYGAISQETRNTPSYPDSAETLIKYYLTPVFNWTAFSTDAGIPYLNFNDWLHYSGDIDHCLPDLGQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6M9</accession>
    <name>A0A4V2K6M9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_831374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145235">
        <property type="protein sequence ID" value="TBU52823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6M9"/>
    <dbReference type="STRING" id="114155.A0A4V2K6M9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="205"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="628" mass="70971" checksum="A4B52390B8A0C0E9" modified="2019-07-31" version="1">MPHPLLYLHQDPPGPIPGDHKLRCCISHDPDLSPKIREACRVAREAGYDYLWIDSCCIDKTSSSELSESINSMWQWYGLAKVCYAFLADVPPGEDPRAEGSAFPSSRWFTRGWTLQELIAPSTLIFLSNDWNVVGTKATLSYIIEEITGISVTALVHATSLDGFSVAQRLSWAARRETTRKEDRAYSLLGIFNINMPTLYGEGERAFRRLLEEIVRRIPDQSIFAWGDIYADLERDQDLGDSLKNAGKLTCIWGNVMGTSLESLFDSKPSDFTDSGTINAISHNDVLNQLKLSEKLPDQEYTFTPHGIRTTLPVLQLSRCLPQHILEQSSSYGLLSRWYLALLGCEHIDYPGALLGRACYIAPSNAGVEYLHYGCVNIEPSPTRGTQWPHLFPLSPAIIKRCRDDIQLKTVYVSHPKRNTIQRGTTLWEAHETINMLLEEATRNALLTQGYTTELRRPDEDRPSAHWLMLFHDDHTIAVESRHILEDAGWRLKIEAYVKMSQHAYDAAEEIEADPSCVRWMDRTGSLPWSLVLNMKEVVFTLATWKLTVKLGLKWAAPSHYFLLIEIVEEMLEATPAVLLEWEAKEERQIFRVDSKADVQDIEAEESGVGVLDADDNVLPGMPTQTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K743</accession>
    <name>A0A4V2K743_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Copper transport protein 86</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_951256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K743"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU54668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="490" mass="54694" checksum="FEF42086B981D560" modified="2019-07-31" version="1">METCVSLAKFTRNLVAQNPANQVRALEVEPAIRSLVFRYTTYSATQDPTSYPITRVLTQTLSNIVTSNDYVAQALWTTYLNLPEEQLILTRLFASPDAQTVLVAFVFVLNCIHESRPRIEQLAGSPRGPRTCFGFLDRMASLFEAEESSAEGRAFDLGYEIFTRVIEAGLVPTLYRSLTVEDEPITPHQTTLLKMVDSFLHNSESAYELSSRRHDPDGRYLLDMLTERFLALSRYTQDSIQRALGAYIFFVHESPTHYSADTHSNESAPLQELDLLLPKVCEALVLVTQCLTTITLRAEETATARSLPSRTDDEVAAHLSSNPLIVISAMFLDHGVVDSLVETLRLVDTFVPRITYGKVVRRPTAPNQQESHSTSEAASSDGTRSMSPNPELIRAAQAFAHVKRDLVRLLGIVASQNRAVQDRVRESGGLPVVMNLCVVDDYNPYLREHAIFALRNLLSGNPESQAVVDAIQPVGKWNEDKVLQELRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8N3</accession>
    <name>A0A4V2K8N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1002855</name>
        <name evidence="2" type="ORF">BD310DRAFT_1031524</name>
        <name evidence="4" type="ORF">BD310DRAFT_464589</name>
    </gene>
    <organism evidence="3 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU54876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU60608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU64054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8N3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11307" checksum="C223D0FE45638659" modified="2019-07-31" version="1">MLAEDEYLAFDNDLGEFDPDDYLDSCIEEVDSSPPPLADPPPRTHARSTLYENYTRALSNSMEAGGMSLEDRVLACIDYMNTTGINLLVTASRDAVSTALTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8Q8</accession>
    <name>A0A4V2K8Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_975436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8Q8"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="111" mass="13305" checksum="2580F91DDE60B95E" modified="2019-07-31" version="1">MEKTGPMPRPSSKAWGKKWKTMVEQEEQLKAEQKKREFKRKKKKFRRKKKEIDADTAPIEADLPFSQHAWREITVLKILRYAMSEIQQFREEMEELRHKMRLTCGAISNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWG9</accession>
    <name>A0A4V6MWG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phospholipase D1</fullName>
            <ecNumber evidence="3">3.1.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Choline phosphatase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Phosphatidylcholine-hydrolyzing phospholipase D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_872789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phospholipase D family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="3"/>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V6MWG9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000011">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF76">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1495"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1640"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="620"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="693"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1413"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1653"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1687"/>
            <end position="1700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00079280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1757" mass="198457" checksum="E7C25106A51DD47F" modified="2019-07-31" version="1">MASVARPPEGLVDVVKHAISNHQHERSADKAALDRHPSTPPLARPPVDTPAVNRSHREEIKDDSPWKDNEDGKDNVKKSYEKLPEQPARDRPEDTSPASPVSKRSFPVSSSRNSTVQRTPAPGTPQQRSGPPRSISYSYSISSAAGHGFPAASKREGSSRQNSQFEDEDPDRVNDFPPAMSPFRGALDYEEREQRERRHKRRDSYFQDASWNPMKWITESPRQTPRDEEPSPRPPHRTYTEGGHRDEDSEDEQAAAGPSGATPPQSPTSPRLRHARSMPHMKNEARTPQTPKWGRLRSLLPHIAGQAKAQHSSARSVAPATVNITDELITGGLATLMLRFWIERDEKGHRRVPALFHRLKIRVTDSLHPMHGHKAVFRIECEYAEGAVRWVVYRQLREFISLHGHYAVSKAYNRNIDALPDFPKTTLPYFRFLKERGSDVGKADFARLQRETLENYLICLIRAVMFHPAVNRLAGFLEFGALTVALAQSGGTQYKAGLLRLEGVAPKPSFGRRAAGWREKQKQRWCCVRESYLVVMEEMGELTVWDVFLIDQDFAIERPTRYYRQGMHLFHLDSESANQEEEIMAGGQEKAKVEYEPPKRKRVASTVGTIKSAVSKILHPGHHHHATNGHGHHSRSANNLTVDDGHGHPRPSTDTRATSSSSSSSSSSGSSHPFTPMLDPSTNTNPLEPAQHAQEHEHREHEHHDGGDETKKKKKGSKDVSKHVFYVVNAQTRLKLTAKNERQMLQWITSLERAAKDSHYTGRNRFDSFAPIRLNVAAQWLVDGRDYFWNLSRAILLARETIQIHDWWLSPELQLRRPNMDKYRLDHLLEKKAKEGVKVYIILYQEVSNRTTPTDSHYAKQRLTALHPNIMVQRSPSHFQTGTFYWAHHEKLCVIDQAIAFMGGLDHCFGRWDTPQHVLVDDPEAESDGGDHIWPGKDYSNPRVSDFHTLNKPFDDMYDRSKIPRMPWHDVSMQVVGQPARDLARHFVQRWNHLLRIKNHTRAMPFLLPPPEFKPGELADMGLTGTCELQICRSAGPWSLGTPDRIEHSIQNAYLKAIQLSEHFVYIENQFFITSTVVNEVKVENRIGDAIVHRIIRAHRERTPWKCCIVIPLLPGFAFPVDHSDASAIRIILECQNRTICRGPHSIFGRLRKEGIDPDDYITVFSLRNWGKLRGDVLTTEQVYIHGKVCIVDDRLAIIGSANINERSQRGDRDSEIAAVIRDTDMIDCTMAGKPFRVGRFAHSLRVRLMREHLGVDVDALYEEDLMSSEPLQEPHEQNAWDPDMEQEFGKEAGVTRISKAHQHTSKGALMHDIIDGVEQALHGTGQVGAKDMSKVIRMAGIKSQGADNTAGDKFLREEREMSTHDGKKEPGFPSSVVPTLEEKTIMEHRPHQTSPIEEVPEDQDGSRTPTGNDRHQTGEARPSSEDARVQNGDAPKNQQENGSAMDNGDANRGPVVQDRSSDTNINGDIAQTEAADRTPPQAALETGELYGAPANAAANPREDNEVPHAGSSKVDAGSDEEKAPGARAMLRKHLAAKLGSKHWHLPTRTPHVDPYGFEDPICDAFWKDVWVASAAHNTEIFRKVFHAIPDDLVTTWKQYKEFVVHHERLIKPLKDHDPSDPPLARMPSEAADFDAPGQQRIAKQAANASEDELAREKEHLDGDGDSRTLHTPQPPESPSPVQGQSQKDKDKDKDKDKRQNKGPKPFDQSEREEMENLLRELRGHLVLYPNRFLEGEDVANNFLFPADRLLPLPIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWN5</accession>
    <name>A0A4V6MWN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_110554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWN5"/>
    <dbReference type="STRING" id="114155.A0A4V6MWN5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="252"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU53998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="368" mass="40663" checksum="33571C0CB7D5F991" modified="2019-07-31" version="1">MNEPSALAPSTEPIPPAASAMSKLGLKTAPLEMDEPDTPLVIDISGPRRDTPDLDEGEEDEDEEEDDDDDDDDDDDEEEDDGDDDMEAGMDTELTIRVDGEDVTPRDSDATDADMPHSGKHTDGGSTLYGSTAAAGSGMGIGSGGEHVHEHPLRLDIHPPSPPLGPWDSTRERDDDDEPGEFGLAERRARASPHRYAMSGTKANKVHEFGNKRSHNRPLIPHSSYYFGPPPPDSAYGSDPVGQIGVHHPREIVRVERDYTGGELPQFTPTYPLELEGRITPTQFLETINAINELLLSAHSLSHAFVDNALAYFTLQVSRAVKKTHYEKEMDRLKALIDELNVQMYNPVGLHIKWPRSVAFLFLEIEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWT0</accession>
    <name>A0A4V6MWT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_479332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWT0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16822" checksum="1649BA19FADAE498" modified="2019-07-31" version="1">MSSIAAACARSARAVSALRGARAFATETFASGSSSSATDFLPAQDRTGSSARLRQQANVSHHDVKSIYVRAWDDISTMPEFFAILRGVERRFGTVKEFRVGRVSCIHVIHFCVLSSAIFTCHTEDQCIRVLSQAIRNRWGSSMCQRSQFRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MD47</accession>
    <name>A0A4Q9MD47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_861424</name>
        <name evidence="13" type="ORF">BD311DRAFT_670129</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="ML143465">
        <property type="protein sequence ID" value="TBU25215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145239">
        <property type="protein sequence ID" value="TBU52722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MD47"/>
    <dbReference type="STRING" id="114155.A0A4Q9MD47"/>
    <dbReference type="OrthoDB" id="10267115at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000468">
        <property type="entry name" value="Short-chain dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU25215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU52722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="314" mass="33715" checksum="1A87E2D6ED3766B0" modified="2019-07-31" version="1">MLFSKKWDPRGKHCFITGGSSGTGLALGILLAQRGAHVSIVARDKTKLDGALKKLKSARQDPTQVFKAYSFSVDSEVGSAAALKAAAEPHGGRCPDALFLCAGASRPGFFIEHTEQTLQEGMQVAYGAQAYTALAGTKEMVKQGVKGKIVFVSSVLGFFSFIGYSAYSPGKFALRGLAESLRSELLVYGIDVHIAFPATIFTPGLEEENKVKPEITLKIEETDAGKHPEEIAAGILKGVEKGTFHITTDILGHIFRASTAGASPRQNFLGDILLSLIGYIGIPIWRKTVDSQVIAYRAQHAEYLRSKGVPENLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MWT8</accession>
    <name>A0A4Q9MWT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_865000</name>
        <name evidence="9" type="ORF">BD311DRAFT_715191</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MWT8"/>
    <dbReference type="STRING" id="114155.A0A4Q9MWT8"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU32479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="216" mass="24353" checksum="30352BEC0F1BBF31" modified="2019-07-31" version="1">MSEQQATIPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLSFSTNFGTICFNVWDTAGQEKFGGLRDGYYIQGQCGIIMFDVTSRITYKNVPNWHRDLERVCENIPIVLCGNKVDVKERKVKTGSVTFHRKKNIQYFEISAKSNYNFEKPFLWLARKLVGNPSLEFVAAPALAPAEVQVDPELMRKYAEELAQAEAVPLPEEDDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MYK2</accession>
    <name>A0A4Q9MYK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_938940</name>
        <name evidence="8" type="ORF">BD311DRAFT_750336</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145229">
        <property type="protein sequence ID" value="TBU52979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MYK2"/>
    <dbReference type="STRING" id="114155.A0A4Q9MYK2"/>
    <dbReference type="OMA" id="FHEATPK"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000012">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU32607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU52979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18476" checksum="5A546F17B29A90F3" modified="2019-07-31" version="1">MSVTLHTTHGDIKVEIFCEAVPKTAENFLALCASGYYDDTLWHRNIKGFMIQTGDPTGTGKGGQSIWGKPFPDELRSTLKFNNRGILAMANSGPDTNKSQFFITYAKQPHLDGKYTIFGKVIDGADSTLDAMERVPVNAKNRPLNEIRTTHVTIHANPIADAQLVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MZF7</accession>
    <name>A0A4Q9MZF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_870340</name>
        <name evidence="2" type="ORF">BD311DRAFT_861936</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MZF7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MZF7"/>
    <dbReference type="OrthoDB" id="3251353at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="23075" checksum="D433809D7B4F00AF" modified="2019-07-31" version="1">MSTDSAYPDFFRRRPIGRAPSPPTWACYEQIPYGDDYSDSASDNDSCSEDEEDYEHARSDPERPVSTGDARSTQIDGDLEIDEGDDAISSEKVAEMKKDVKGKQRAVEHFESPKREHRKKHRQQPVFTLRPILTIQKSQGFVWNQDLFVPPYIKDRYVASTSPSNSRGFVSSSVSSTNSSMMDYEVEVVEIRVREGELNDIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N7R9</accession>
    <name>A0A4Q9N7R9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_942400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145343">
        <property type="protein sequence ID" value="TBU51297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N7R9"/>
    <dbReference type="STRING" id="114155.A0A4Q9N7R9"/>
    <dbReference type="ESTHER" id="dicsq-r7t117">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="87"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="330" mass="36125" checksum="CAC28A4A6E9C3DD3" modified="2019-07-31" version="1">MDPEYAAAVAPLLNAPHPTTPPSVEQVRAHFAHSLIEPNKSFHEGRLPPASAYSVEDRTVKVDGGEIIVRCITPLVNDEGQTFPVFVNIHGGGWCVGSIEIDDYHLRRISVDLQISVVNVEYRLAPEHPFPTAVNDCYAALKWTVENAPSLKVDLSKGFLVGGHSAGGNLSAVLAHETKKDPFFAGRQITGQLLREPVVVHFDAYPESLKGELRASVENKDNPPLTAAVMLGLFHMYQGPPADPRLSPLLYPSHEGLPPAYVQVMGLDPLRDDGIVYEKTLKAAGVKTRIDLYPGVGHGFYYNFPSIKLAELVRQDVVKGLKWLLGRSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAH8</accession>
    <name>A0A4Q9NAH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_932376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU56000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAH8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NAH8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="468" mass="52717" checksum="A9F529D62FC798E7" modified="2019-07-31" version="1">MSKGLVIVVTGANGGVGFGICHRLLVNLSSANPPDAQPFFNVKEADPAYARSYHGILNEYDFSDPEAGVTIIMACRDPKRAQDARARLYALLDQHIAKISLGSKDHAYASTFRRNVRLELETLDLSSVRSVLDFGRRASDRYEYISHLIFNAGTATYSHLDILGFVLDLFRWPVHAVHHPRRNMQVNGVLSKDNLGYTWQCNTFGHYMLYRSVQDLLLAYTRHTSRSARVLWMSSLDAEPEFDPADDWQLTKTYHSYQASKFQIELIVSELEKRTIEAQETGRASSLGETVAPHGEIHHLIVSPGITSTNMSSLLNIWIPGWRYLMIASFWIVRLLGAPHVLMSLFSAAVSAIHLALVPLAAVPTVRSEPRISPLDVEYPYWHAYHKKCSDRVMALRFGSENDKWGRDRTGVIAVPVWEEHPNAGEVLLERFERLYQAYEVGYEDGEREGKESGYANGHAKAANGKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB48</accession>
    <name>A0A4Q9NB48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_849374</name>
        <name evidence="5" type="ORF">BD311DRAFT_823728</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143538">
        <property type="protein sequence ID" value="TBU22517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB48"/>
    <dbReference type="STRING" id="114155.A0A4Q9NB48"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="4">
        <location>
            <begin position="5"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="3">
        <location>
            <begin position="527"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU22517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="850" mass="94437" checksum="FB1602EE443355E6" modified="2019-07-31" version="1">MTDHPTLSWEAMQDGSVFYRRHQLYSIPGKLPGDLQDFIVAGCRYGGPIALMRDTSKLVAVNRAAPAFSKAQISIYSPAGEGILLFSWDQGKIVRFGWTGDERLVVLNEEGVYRVYDLQGEYQQYSLGSEAGELGIIDARIHESGLVALTGSLTFLEVKEWSGGKPLTLANPGLSQPPQSWAVIPPDQTISRHVEVLLSVETTIYSVDNLESLDQRISRGPFTHMSPSPNGKSLALLTFSGLLWVVSTDFQRSLAEFDTSTVAGASGDVHQVEWCGNDAVLVTWPNLAVLVGPFGDTLQYFYSGSTFAVTEPDGIRIIGPDTCDFVQKVPASSVSVFRPGSTSPSAILFDAWENFSRRSPKADESIRSIRPELAAAVDECIDAAAREWEPFWQRRLLNAAKFGRSFLDLYDPTDFIQVGQALKVLNAVRFYEIGIPLSYTQYTQLSPTHLISRLLARNLHLLALRISSYLALPPDAVLKHWACAKILRSKPQTSGTGKNADLESGDEALSRVIVEKFETLGRGSSGVSYADIAKRAWEVGRTALATKLLDYETKASDQVPLLLSMKEDKLALLKAVESGDTDLVYHVLLHLQKRLSLGSFFRLIEEGGPKLALASRLLQVYAREQNRDMLRDFYYSDDRRVESAVLCLEDAASASDPTAKLTSVKAAQKFFSEDKDRSFEAKMMDESVRLMTLQQTLEKEADGKIAFFGQSVNETIRTCLVNGMAKRADKIKSDFKVPDKRFWYVKLQALTSIHDFEGLEAFAKSRRSPIGYEAFVKHLVEKGHQKEALSYVPRCDGPKRADLYVLCNDWRAAAKECKERGDKAKLEQLRKSCPNSLIARELEQVAASMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB65</accession>
    <name>A0A4Q9NB65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Translocation protein sec63</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_920977</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB65"/>
    <dbReference type="STRING" id="114155.A0A4Q9NB65"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="594"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="598"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="632"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="667" mass="74261" checksum="402FB1D20263E945" modified="2019-07-31" version="1">MAKHNYDETGNMVSYFVFSFLSVFLVPYTLAAISSTKSPSLSGCQCQHCIAQRERIRKRERGSLLSPKLRRRTFIILAGWSITAFFAYKILTAENTSKIYDPFEILGISTSATVKDIKSHYKKLSRKFHPDKVKLGVNETMEMVEAKFVEITKAYKALTDETIRQNWLNHGHPDGRQEVNTAIALPSWMSDNIWVLAAYGIIFGGALPALVGRWWFGNLEKTKDGVHARSAATFFKTLTEESGIDDVTTSLGKAFEYEHRVKIAKADGELDQLETQIKEQLGAKWTELVKVAEAVPGAHDSRRRAFVLLYAHLLRLPVHNSSLQKEQTELLLQTPTLLNSMLNITMSRNWLLPTLAAMRLHAYITQALLPSKADLKAAQLPGIEQSEAAALSKSESTDFSDAVSTLSKSESSELVNAHKALECLGQTEIVDASFKVIGERFVTPSSFVHLVVKLRVDPLDKDGKPVPIPKQDKENEKRDNEFLLSKKDAEDLPNGDYASQYAHTPYWPANRKPSWWIVLADVKSNKVVVPPIKVTDVPVADTQRGIDYRAYKIQFQAPQNVGLFTWKVIVLNDTFVGDEASRDVVLKIDDPSVLNADDANDEDDISDPEEDSLAGQMALMRGGSVKKSQPQDGEDGEDGEDDEDDESTTDDDQEEKGDGSSSDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDE2</accession>
    <name>A0A4Q9NDE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_978095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDE2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NDE2"/>
    <dbReference type="OMA" id="EGVFAMS"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="439" mass="46946" checksum="CFC951D1A633208D" modified="2019-07-31" version="1">MIAVQKPPSMFSSPIFRPTHARHPSAPVVVRPSHTPGVLNISKPPSHSAPRPQLAQAQPRAPRASPKSKPQQRSLQPTQTQAAPVERPKALNPSPAKAEQPSTTNDKPPRGRKQHKQPKDAGGRDNSVSPSNVVARRHAHQPSPSPRIPSPSKAAPASRVRVSSVKPEDKTSTDPFTDDANASAQDGKADGKAFRSPPKLSSQPSGKLARRRQASAQLLDSPTPRLPSRRKGRAQGETIAPLQSAFPTSLPPRQASADMTSLRWDSFPICDDSSDFGDDSDVSPPTTPIREVSTVPHRAKGTWLQEKYGVDDAPRTAPMASTSGFPFSGQSPCSTPTPAQRRRNHRRVPSEGVFAMSTDEESPSSSVSDLFESIRQKIRSPVSIPRQRCFTVPTGTPSSFGASSSDHTISSSAPSATGYFAGSVFQNSPSPDDLPAPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NE06</accession>
    <name>A0A4Q9NE06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_725360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NE06"/>
    <dbReference type="STRING" id="114155.A0A4Q9NE06"/>
    <dbReference type="OMA" id="RLYCPSI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="369" mass="42066" checksum="73099920F464BC6F" modified="2019-07-31" version="1">MALPPDACSLIAEYVADSRSTLVNLCTVSKQFQVAAERAIYNTLYLRGHDTTISVCDVLSRTPRVAMLVTALSVYDAEDSDDESDFQPEDGYWQVLHQALKRTAYLRSLDLYFNTGDPPDRAWILDECKFQLRTFHCGLVWDDHLATFLSTQPYLSDLFIADYPESAAEVMAPPIIPSDSTFLPKLSILECTFSEAAVSLVPGRPVCRVKTCFTRSKLEEKREELNSIVSALRRSKKRFRAIDIADSLYTAEFSMELLSTVTSDAQFCVDLRYVGTLVLPVDGRQRLEFYTMLMRLRRLRCLELDVSDWDPAPTHLAALRALTYELRLYCPSIVTVVYVHDFERHLVRMVDHVAICDEDAVTDNLWREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEM2</accession>
    <name>A0A4Q9NEM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_200683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEM2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NEM2"/>
    <dbReference type="OMA" id="LEYRTEC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="393" mass="44734" checksum="C465AFC9F98E0F38" modified="2019-07-31" version="1">MLAYSQSSSSTRTSRASHPFDCRDADIVLRSSDGVEFLVHKRLLRIASRVLTQLIPLARMPPPSSSSGRRHKKERPVLDLADSSENLDLFLRFIYPILEPSIMLNEVYTILELSTKYDAPSVAQRMRPHLLRPDHLEADPYVIYALATYAHMQDIAAVAARHTLSHPIPPTLKLTEMAEGTDLVRLLEYRKKCVAAAVSVTRIADDNVPWWVQLQWRRFCFLSECWECAKLLPGRSLKWHRTACGTVRVPDYWVEYMAAAGAALVEKLDPKVAKDRRLLQPAIECAMRCSKCAAAAWKDVEDFAEILAAAVEEAVCSVKFPVQGDEDEYARDDINALMMPPKTNYLSASDRPVWPMFDYFWDTWRKRIPEEDTTSVILEDDDHTLPPPSERDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLB4</accession>
    <name>A0A4Q9NLB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_961782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLB4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NLB4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="265" mass="29088" checksum="FA80759A2B0AE9FA" modified="2019-07-31" version="1">MSVKTVKLGGTASNITVGKVAYGLMTLTRDPNIPTDEEAAFVAIKPAVDLMPPGAENLRRSVDACLAALRGTKKIDLFETARVDPNEEGKFDHIGMSECRAETLRKAHAIHPITAVEIEVSLWSYEEEARKVIATAEELGVIVIAYSPLSRGLLTGLITSKAELPEVDYCRRFDRFQDENLKHNLAILEEIKVIAARKQVTLTQLAIAWVASRGPHVIPLPGSTNAKRVVENIRLDQIADVLSRHEVKGERYIGGPIAQALHLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNC6</accession>
    <name>A0A4Q9NNC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="8">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_927699</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="8"/>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNC6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNC6"/>
    <dbReference type="OMA" id="ERGLHPW"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00788"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.10:FF:000004">
        <property type="entry name" value="Inositol-1-monophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854">
        <property type="entry name" value="INOSITOL MONOPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20854:SF4">
        <property type="entry name" value="INOSITOL-1-MONOPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="325" mass="35491" checksum="4FCB3DDA14957A2C" modified="2019-07-31" version="1">MTTQLSDAELQSILDFSIGLARRAGEVMLEGSEKIRESGATDEKKNSVDLVTEYDVKVEKLVMGELEKKYPTFKFIGEETFAAEGMKRPEMTDEPTFCVDPIDGTTNFVHGFPHACISLGLIVNKRPVLGVIYNPFLDQLYTGLKGHGSFLSSPHSSVAALAAPRRLPLARPRPLPSLGQALIGIEWGSDRSKEMVDKKGDSFKLLAGNPKEGVVGGKMAHSLRSYGSAALNYAMVAQGGLDMYWEIGCWPWDICAGAIIAQEAGGFVAGSHSAPLDNDVNEDVLWGRKHIVLRAIGDTETEKGIDAQKRIIREFYETVADFDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNV7</accession>
    <name>A0A4Q9NNV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_918279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU62843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNV7"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
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        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="641" mass="71263" checksum="83EA4562F6612866" modified="2019-07-31" version="1">MFKSILPSRRIPSSDFQMLTSPIDSTESDATGKENYFANAYDTNTTNNAKAKADKRKKMKGKAQPESETPQDFDKLLDELQIPSTLRPKLATMDPTVKAAFLKSSHVLAQMKPAPTPFTPRTLRRAQSSESVLSSPRPQKPTLEEYDLTESPIAPMALGTGHSRGKSLDIRRQALDPRPAPIAPLKVSKDKKKSVATTPEKYVKILLAESSTSMDIEVVKKLRLLLRNESASWTEAFLQHGGYDAILTRLNEILDVEWREEQHDDQMLFELLRCVKALSTSAVGCAALRAQCPAPFDKLVRLLYSDKKPGDVPTRQLIVELLLNLFDLYPPSSLPSTGSPGAGLAHSRSRSIPWELSATAMSSTSNLVVLPRPHSTLFSFIKALLLTPAPPPSEAPATPIQPHEFIEELHRPRVYKTYLQELSDLCRDYFWVFCHPSNAIWELSETDEAKVEKPRAPGGMTGGVEFEAMCYMTMHFKFVNAIASHVRALNLPKEHEHSAYRFHQDMFLSGIERILSIARKASTTYYPTLHLEIARYVAFAGLSGIDVPWSLSRMIGQPPTAMRKQPVIPPAPVIPPRTPPSRSMPTTPTKRGAPPAGFVGYAAPQQLVYPSGHDGAPSRTSVDRERERAQPQSRKVTPMFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NP44</accession>
    <name>A0A4Q9NP44_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_917290</name>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NP44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="139" mass="14955" checksum="A4611F44853784AC" modified="2019-07-31" version="1">MLMAAAPQPSGKPSTPPPAYSDYSGYEYQQHLSATQAQTSNPASSAQSPVGVAVPLPFPAHTGYGPTPIPQQTQLLPYYDLRSPYAVAEANRRARWRFIEAALWALVVLSAVSFVMGWEVEQALAGGGLHRRSGVWASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQQ3</accession>
    <name>A0A4Q9NQQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_599752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="276"/>
        </location>
    </feature>
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            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="276" mass="29894" checksum="7E15B51C323EA46A" modified="2019-07-31" version="1">MTEYDYSPDAMERYQAKMAGVGKWANEQSYWRTGYTNPFTPEVSSPSSAPRPTSRPETSSSRSRPQPTRSRTLPANLAVPAAKPGGSSAHGHTSRALAYAQADPRAVRPSTGTPTRTTTRHRSGSQPAPVDVRTPYPYPAPAPGQKVVQAPRGSPMVYAPPGARVIYKEYDYVPGKATVLPPARPGERFVVVPPPGGRVDVMSADRLHSSSHTRSNSRSSGSKSSGSSPTKRSGDPLFKRILTNLKPNIEWGHDRDSSRSRSSSRREGSKLRSASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZD6</accession>
    <name>A0A4Q9NZD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TauD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_918174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZD6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000003">
        <property type="entry name" value="Alpha-ketoglutarate-dependent taurine dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF31">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU62787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="401" mass="44682" checksum="C98523DE5DB260CC" modified="2019-07-31" version="1">MAPVATNDTAQEHVSTGPVKKVAEKLFNPFYSPTNGADGEDGDYKYAKYKPFFPNVKWEPLKEFPVTDRAHNADPEKKSLLSAASKVTHLTPAIGTELLGIDLRELSDSQKDELALLVAERGVVFFRDQEISIHEQLELARHFGPLHKHATTPIPREPGLEEVHVVYTDGSRRPDPSAFSKIDLWHSDVSYELQPPSTTSLKLITGPPYGGDTLWSSGYALYSSFSPGFQKYLEGLYAVHSAVAQADGARAAGQTVRREPVESVHPVVRVHPVTGYKAVYVNPGFTRRIVGLPKAESDAILQLLFHQIADNPDFQVRFRWEPNSIAFWDNRIVTHSATFDFFPHVRHALRATPHGERPTSVEDFERASGRAAKDWQKDLWEKQGIATDAPAPRAGPRGYND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P0Q9</accession>
    <name>A0A4Q9P0Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_919286</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P0Q9"/>
    <dbReference type="STRING" id="114155.A0A4Q9P0Q9"/>
    <dbReference type="OMA" id="FWQNEEF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011629">
        <property type="entry name" value="CobW-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07683">
        <property type="entry name" value="CobW_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90002">
        <property type="entry name" value="Hypothetical protein YjiA, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="9">
        <location>
            <begin position="44"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CobW C-terminal" evidence="10">
        <location>
            <begin position="345"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU62374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="412" mass="44934" checksum="8A27BE219897A4F1" modified="2019-07-31" version="1">MDDLGEIPELVDADTTSAEDAPEGLSIPNLADANDSEHPPRTVPLTIISGFLGAGKSTLVRRILTERHGYRIAVIMNEFGDTADIEAKTINVSSPDDPSQQSEEFLELANGCLCCSIKDTGIAAIEKLMKRKGAFDHILLETTGLADPGPIASMFWQNEEFSQGLGRDIHLDGVVCVVDAVFGRQQMEEDHAADGIGESLRQIAAADVILLNKVDLVPPAEADATEAVIRGVNPAASIHRTVRGEIDLKHIMGIDAYASRQLLEVSGARVAKSHRGEHEHDHNHNNVHDHEHSTSPTHYEIRGISSLQIDCPKLSSQQLDVLDEWIRSVLWENKLPGSPSGDNSGLEVLRCKGLFVTTVGDLYVLQGVRNLYEIAKVEDEELGLPDAGKLVFIGKGLNEHVRRSLQEQLKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3A0</accession>
    <name>A0A4Q9P3A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_785465</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3A0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3A0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8406" checksum="3B424C51C1319E2A" modified="2019-07-31" version="1" fragment="single">KLSIHRKFVFALKGDVYLHYNPFATPDDLRKQVCAYNYTPFGIGPVYSTCKIDRPSTLTPQFRNLIFDIDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7M8</accession>
    <name>A0A4Q9P7M8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_946704</name>
        <name evidence="2" type="ORF">BD311DRAFT_865922</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143429">
        <property type="protein sequence ID" value="TBU27669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7M8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7M8"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU27669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="488" mass="53231" checksum="A87D7FCD60721B76" modified="2019-07-31" version="1">MLALAPQPMHTPVDVPHRTQPPTPSSSTRPPYRKVTPSYTSASSSSHSAHTSHSGSYSSHSAPLEPTSSSRRSTPQRTPSFASSARPSVYDGHEDDPSTPPGSESEDNEPESSVQFASAEVDIHAYDSTTLLRLLANALTEIATMNTDRDHSEPYLSSAHSHTSPSEPHPPIWRTLTTASRHALSTASSLSFHARNVPTIALEAYLTRIQKYCPASNEVFLSLLVYFDRMMKLAKESCGKVFAIDMYNVHRLVIAGVTVASKFFSDVFYTNSRYAKVGGLPLTELNQLELQFLLLNNFHLMISQDEMQFYASKLLQQSQVPPGVSLIPFLPDSSSSVPHDFRRSPIGPVKYFATLDGYVAHLHARAPPTQRDSGTHYSAPPNTSSSSRTASGYRRSTSSYSTSSASDTVTDSGDTETDIDGETDDEPTIRAPHSSASSETMSLHSAASDADSIYTEDDRSEVGEVAHSHPLANGARTEDYRQRNMMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P915</accession>
    <name>A0A4Q9P915_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_653037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P915"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14903" checksum="14BF9E9F0D755163" modified="2019-07-31" version="1">MRAHPRIRGSSPCLLWPTFASIVTRAVRISRGYRPYALSMRIFRSRYRRSMQDDPVVSPLISGGAVPERTYLSDSLSSFSPIQTQTSPYCPCTPARSLSHDLCFPSTSVEAGVGPRNIGVRVALRVPVKSSFTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P933</accession>
    <name>A0A4Q9P933_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_842432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P933"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="577" mass="65354" checksum="84E2210207D1B17C" modified="2019-07-31" version="1">MTVLHIFALFDAIDTLRIVDATLPSFSVFWGREGTDYMRNLAQVVSRLNMKQLVIHNPVLRSLWVDTPECPRICELHGLLRDPQSELQLLAINIAKAVWYNLVFGGRQEGGKFQADSCNALGAPARLQHLTLGFFGFHRMLPVKETDFYQLIIIRNTDLIYAAPPRLQEVTLHFPNLLPLEDFRESHSSTTDKSLLDWSEQDGALASKVYLRVDTAIVPHGTYPFPAIDEIFRRWSTQSNPPFAPLPEETVFKRIKQLTLQELKISPSNVIDPIVRAFALFKSIESLYLVHTRLPWLLPNTQSAPVDVIFYRLQVRNLVICSDDEAVSVFERAVGFLLRAPVVRPPLRSLWVDCIDIPKSIALQDFLRDSQPPLQDLGINVFRPVLQSYLDRGHDKEFISLTTALSAATALQRLSLRLFNFLLMLPPAPGFDIYEYVITCNTELVRATPPQLSEVTLQFPSLIPAHNAMRKPSAPDYPAVDWRGLDDALVAKSLLRVVTALLPHDTYPFPLPYETKELRVFEAFSPLSEETVIKQTVITDHEEAITYLKKAFPQTYLRGILKLMVAYPDGSVAVCDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9A7</accession>
    <name>A0A4Q9P9A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_779259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145515">
        <property type="protein sequence ID" value="TBU50968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9A7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9064" checksum="E8A86AF1788ABA54" modified="2019-07-31" version="1" fragment="single">MPTDQAKKLKKVKIHDNRKPPPVSAPTAKPPRGNQAKAIVPLPGTPPGQKRPPTPHDDGPRKKKLKPAQDAPSSSDTQGADTVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAP9</accession>
    <name>A0A4Q9PAP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145289">
        <property type="protein sequence ID" value="TBU51744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAP9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="17285" checksum="B42209B2A55501F4" modified="2019-07-31" version="1">MAMEDWMDFFGTRGALRFVNVVCELGVEIGLWDVLSQHPPRLLELLGFNFSVHTVERDVDTGDPVFSERWSWPKAFYAAVEHEEEEDWEWLLRHHGHNDRIDIAEWMLKASDEGLDPHGAGGAGPESASSNVVDDGEDDYEGGSYEDSMEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAX8</accession>
    <name>A0A4Q9PAX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_833471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145281">
        <property type="protein sequence ID" value="TBU51849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAX8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="289" mass="32459" checksum="DC229B86DCEFA1ED" modified="2019-07-31" version="1">MKHKKSADDGELPAHAPTGLPDDFNADEDIGIGDSYSLRGLIHYRCIIEQVEKMLGGAGSGHELLSRIADCVQAHQQANEKSESFDRNVSVDNELSYPKLDVTEGDSVGRLTDQGLSVNLEGTCRSLQREQPEIGQFSSYAIAISRYIYFNGRSKLAVVADDLESFWYILLYHAILRIRSNCSGWAIWIQFFQSHLAILEREHAVRFGVLEIRGVGKLSFKDATINGVIYDLLGLFPAHYKVVEYDRRRKLHPSDKNPPPTGAELALAENVKDHEMFLEILEKALISLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCX4</accession>
    <name>A0A4Q9PCX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_861544</name>
        <name evidence="2" type="ORF">BD311DRAFT_675209</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143525">
        <property type="protein sequence ID" value="TBU22827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145241">
        <property type="protein sequence ID" value="TBU52680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCX4"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU22827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13862" checksum="C87A58330740AEB0" modified="2019-07-31" version="1">MTLAGGSNCWTLWVHWVWTCAMLLAILRALHVVENLDLSLMDGILRENLYISGEKYMAEIWEANQAAQLQDVIGFFDGKLDQSLSARGNELWKGQMRLLVLLRKNKIVLLDVAPGKLYVETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD00</accession>
    <name>A0A4Q9PD00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_970666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145239">
        <property type="protein sequence ID" value="TBU52714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD00"/>
    <dbReference type="STRING" id="114155.A0A4Q9PD00"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        <source>
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    </evidence>
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</entry>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU51562.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Makela M.R."/>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A4Q9PGC3</accession>
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            <strain evidence="1 2">CBS 464.89</strain>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHG0</accession>
    <name>A0A4Q9PHG0_9APHY</name>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="5">
        <location>
            <begin position="54"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="514"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="664"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="782"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1107"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="514"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="531"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="547"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="594"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="799"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="811"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="862"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="897"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="955"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="992"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1038"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1162"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1220" mass="121537" checksum="BF570C80FF98A2B7" modified="2019-07-31" version="1">MNVNQLQPPPSSQLQRFSKQASDKHADFLALKLLNRRTRLRLSPEPLQLDDLPQRARLFAVANTKRSFAAVVRASDGSYALSLSPLTDLRSTLTSGRSDSGPLLLNPNTTIPLQPGTPHILVLTRDDSRILVAFTNGSICVHDWSNPAPLFTFSSPTGKPVRDLFPSTGDSEIVAVLRQPGDGVTVELLDVHKMVSTGGWSAGGSPETNATSVSWSPKGKQVAIGLESGDIITFSPSDTSAVKSVVPRPPSVEGQTLISIQWLSNTEFHGIYAPAGPLAPDSEQTHFILTLEAKASLVGDIKLITPYLPFPGLRPPGSFIVTLKNWEPSRLLLFVGDSTSSDIGLIGSLASASSSADSWYNFTLEEESTPSVPLDADLNETVLLGLDLDVTNTETFRYTGVSGEATDVPPPPIMYLYASDGTLQGWHIIQTQGVAYPDMASAVTPVSSSSPVAAATPTAQTSAFGAPQTASATSSTPPAASAFGSVSPQDATAAPSSGGGFGFSAFSGAPSAFGSTSFGFGQQPQQQEPKAPSPLQAPPLSAPTMSVEMTSATDDSMASETDSGFGGLSLGGGGGGGGESSSSGTNSMFGSFGTNAQQPTNSGFEAGSSANSTFATFGSGPIKPATGFGAFTSSGSSAFGSSSGGFNGGAFGSGSGAFGSGASSTSSGAFGSAQPATAENKPASAFGQSGFGAAAAGAKPAFGQSSFGQSGFGQPSFGQPSAFGKPAFGTSSFGASTSPAKPATTSAFGSTGSSGGFAAFASQGTSTFGAVAQKAADSKPAWAAATSEKPQESTSTSGAFGGSGAFGGSSGTSAFSSAKSTETPSTTSTPSGGAFAGLGQSSQSTTGGSVFGKTTFGQSSFGQPAFGQSSSAQAGAPSTPSTNPAPTSAFGSGGGFASFASAGPSAFGAAASQSSDTKPLWATSGADAKTPTEQPKSAFGFGSTTPSAFGGAEQAVSTAESATPASSPEKLTPPVSTLPATPPAKTEPKPEPTTTPAATTTPTSTTPAAGGAFGGGAFGGLKTSGTGFSSLRPGFGAFGASTTPPSSSPFFQKPSAASVTPTPVFGSSSFGTSTTTPPSKDTPPGVPKFGAPSFGAASFGAPSLTSTGFFGKPAASTPPTATTPETPTNAAAKSAFSAFSGGTSPFSAAASGSSGKSFGDLLRQKEGEDKPESGKKEEKKPAGFSRTADEWKKPVSVFAQLKEAAVEKGLPHRTSSRPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHT6</accession>
    <name>A0A4Q9PHT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_939931</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145245">
        <property type="protein sequence ID" value="TBU52576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHT6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="65"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU52576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="526" mass="56367" checksum="4CA7F6739C428A4B" modified="2019-07-31" version="1">MSFFEKKSADLESKGEAYPDPPVAGNGVNDDMFEDGSVDPVYQAKARVLNAALQEIGMGKYQWWLFAVAGFGWFADSCWPLLGGLILSPVVNEFHFNGPFLSLAQNIGLFAGAIFWGFGCDIWGRRLSFNITLFVTGVFGLAAGGSPNFVTLASLLAVLGLGVGGNMPIDSAVFLDFVPGTHQYLLTVLSIWWSIGQLVSALIAWPLIANFSCPQGSTTCTRADNMGWRYLLFTLGGMTLLLWAIRFFVFPLEESPRFLVGLGRDAEAVAVVQRVAAFNGRQSHITVDELTRAGEAAAASAQAKSKGSKSKRQVLSKSSVFTTKHIKSLFETRKLAWSTSLLIALWGIIGLASTLYNSFLPFILASRGTQFGDGSYYITYRNQVILAVIGVPGAFLAGWAVEQPYVGRKGTLAVSAGLTGVFLFATTTARSSDALLGWNCGYAFFSNIMYGVLYAISPELFPAKDRGTGNGLTATATRVFGIMAPVIALYANLQTAVPVYVSGALIIGSGALALLLPYEPRGKASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI87</accession>
    <name>A0A4Q9PI87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_829294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI87"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="483" mass="54076" checksum="C876DDA7F530BCC7" modified="2019-07-31" version="1">MLSQWFSHSSYLHQCDTLIVDINDLLSPRYTKITTSIPPEMLSQILRSSTWFDYERGNLTEAECYSNLATAYALPESDIAAAVRSSLTLARVVPEAVRILRDIKATTGVRILSMSNFSAPDWNALSTQDDFAKLLGLFDCSFTSAAAGDRKPNLGFYRHVLHSSGIDPQKTVFVDGRLEHVVAGKSFGMKGIVFTNPEELSRALRPLLRDTIADAERWLHRHPKQLWSVTDTGVIIEENFSQLLLLEITQDEDLADIVRLPRLTNFFRGHGVLTTAAFPHDLDTTSIACTVLDHFGPQVKDDIMNEILSLRNEDGLVQTYFDKTRPRVDPVVCVNVLTFFYANGRGSELTETLDWVYDVLANRAYEGGTLYYHSGDAFLYFLSRLLHASPSLTNRFSALYAQRIVERYGAPGDPLALAMRVLAAACMGMRDLQDYERLLMLQQEDGSWPLGWFYRNGSTGILTGNQGVTTAMAVAAVCRYRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ66</accession>
    <name>A0A4Q9PJ66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_828665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ66"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJ66"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="200" mass="21962" checksum="E680A45F9E479444" modified="2019-07-31" version="1">MRKFKSKLYKRFKRFTRPCTDEAGDASIDAKSAGVARIRTAVDGGGAALASISSAHTVVAKGATAIEPATEAVQGAYELWKPVLDKVAVFASLIEAIGDLHPYAKIASKVLLSVVKVRCFPHKRDNAMADLLEAMSDLYDLVNKTGRFADLDQYRKKLLKDMSSKTEECAKFIRDEARSTNFCESVSRRTLAMTHTEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ83</accession>
    <name>A0A4Q9PJ83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_936587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11069" checksum="4EEE16E359C9ACAD" modified="2019-07-31" version="1">MASCPNTLRCEYHSTFPPPTQFCLPPSTPFPLAHRIRVVASSFSHPHPLPCLAEANFPSFLVIVVLTGCTSTRALRLCVVEDVRGGGRQFECGQGGRVQCVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJI9</accession>
    <name>A0A4Q9PJI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_936365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJI9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6194" checksum="DC1E858C43E8E1D1" modified="2019-07-31" version="1">MLGVDRTTDLSYIPGYSVVSHVCVILSFILLVAVPLRATSSILRLKLLVRTSPLPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKD1</accession>
    <name>A0A4Q9PKD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_885944</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKD1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKD1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020221670" evidence="14">
        <location>
            <begin position="26"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU54546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="503" mass="56423" checksum="9917ECD990965502" modified="2019-07-31" version="1">MAPVLASLAVVLLVFLALRLRREKGTPFPGPPPAPVLGNLLQLPTTKVWERLNEWGLTYGPIYQIHLFSTPLLVLNTAEAAREVLDAKSVLYSNRPLPKIIEMTGFDKGVVLEHDPLRLRQARKLLHLVLQPRQLSYYRAVLEHHVNVLLHNCLHEPDGFVEHIRHLTAGIAMEISHGHRVTSRDDPFVKKANVFADNFAEASLPNNHIVDWLPFLANFPGWLPGMGFKEKARRYREQYWSLAEEGHQMVKDDIAKGLARPSLTYKALVEGKPGEVPDDVIAFTATQVYTGGADTTVSTLSSFILFMVKHPEVQRKAQEEVDRVIGSDRLSSFADRESLPYVDALTAEVLRLRPPVSVVTREAGQDDTHNGYLVEKGTIILVNFWGMLRAEEHYPDPHSFKPERWLGKDHSDPTHPFNVAFGFGRRHVSCPGQHLAEELVFTTVARILALFDIAPIKDEHGVSVIPSDDSTNGGITFPVPFRCSIQPRSARARDVLEGLEHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKT0</accession>
    <name>A0A4Q9PKT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_885621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKT0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="263" mass="29368" checksum="D8FC269A04A8E6D0" modified="2019-07-31" version="1">MALDSPNAAFLRERPVVPLPPLLSPSACIFSHHGEGSSLTSLISTLRYIRNNAAKTAPVRRWLDEDYDYDAPEEVARRNQVFEAFARRVAAIESAEAGIGLQSHIEEDTEYADGTRETIGMQLCDVGRKATGRKLCVKKPVSLATTTSRRPSHSQTKTSDSSPRHLKETSDLQAREKRVPDDQTETVPTAIRAGEHPLSKFQVQEFEMVRAYLAKRAAHFEWVSTSSHGLEPLPYPNDIPLSNDIIAYRFELAYDVSCSFYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL76</accession>
    <name>A0A4Q9PL76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1031364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL76"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL76"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="428"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="53931" checksum="5976D0BEFC807B1F" modified="2019-07-31" version="1">MNGTEETLEHALWAPPVYDMSRSPRKLYATHLPQSQVDGGRDSSTVFARMAKWCPDGSVALAQCEDASFRPTEMLGICRDAVLPSSLPACLRQSAPILDYAWYPTAHSRDPACFCFVASVRECPVKLLNASDGNLRASYRIVDHRERHIAPHSVAFNIGANKLYCGFEDAIEVFDVQRPGEGIRLRTTPSKKSRDGLKGKFSRMSITLGAQTYSERCLSVGIVSALAFAPDVASDLYAAGTLSPSSPTASNIAIFSEAHGEVPLMFVGAEDLQSSGGARYGVQASVSQLMFNPGRPYLLYASFRRMDEIYCWDLRGDMSRPIEVFSTQATQLISGRTPRSLTNQRLRFDIDYAGKWLAVGDTEGTIFVFDLAPRSDTVVSANSEGGPTPSTLPVPRTLPTMRYHAHDDAIGSVTFHPLQSLLLSVSGSRHFDSDPSPDTSSASGSEEDIDDGELVARAGTPPGTRAVSRRRTKPQPTASDTTISLWSCAPEMQSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLA0</accession>
    <name>A0A4Q9PLA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_934764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLA0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="331" mass="35547" checksum="A1A8D2B5978C6CCC" modified="2019-07-31" version="1">MASSQISQFVAEYSTFVAQNDCFIAGAVIFLYDAILTTGEEVRCFWGRKLTGAAILFWLNKYLTILYLVWNLGTLLSISDEVGIVTLPCKLSVQGSSAVLYALFLIVAAFAAIRVYALRKSIPLCSITFVLAMVPFGVNFAQFGFGLTGGNMPPFGCSAIGHEPEGLDKKLTIVSRSCLIAADCLAASVTWFALARPRSIHTLGVRQGSLAGVLLIDGLHTDSLLRLQFDIIALQATSEIANFTIPLTAVLVSRFLLHLQSASMRAMDATSSSRMQSTNVNHSLVFEHAIGSLGASISVDDYLVQEGNLSMSEDDNVDGHEIAEPIGPPGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLG6</accession>
    <name>A0A4Q9PLG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MutL C terminal dimerization domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_826680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLG6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLG6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="2">
        <location>
            <begin position="121"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="342" mass="38064" checksum="E58F42392233B87B" modified="2019-07-31" version="1">MPEVIDITVEDDVDLPPRTAPRATRSNVGSSSVSATSDEIVRTGGRETVTVSFDLSTLRASWRKLRERLADALREREDRERERDAKTKLDGTAGLANADDEQAVEALSRVIDKPDFASMEAVGQFNLGFIIVRRRKRGGEGDGVDDVEMDDLFIVDQHAADEKYNFETLQQTTKIESQQLISPEVLELTAADEVVALENIDILRQNGFELDIAEDRPAGQRVLMTAHPVSGSTKFDAKDLEELLNLMQDRPAGQMVRCSKARAMFAMRACRKSIMIGTALNKRQMTSVVQHMGTMDQPWHCPHGRPTMRHLSDLVGVGWDFRKGPWKVEWGAFGRVAASAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMF8</accession>
    <name>A0A4Q9PMF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_933805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU55417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMF8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMF8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="30249" checksum="3A8E293DF632D26C" modified="2019-07-31" version="1">MASPSSPAIPPLNKVYIISTWVETVLWGMFSTLVFSAVCYILFWKRRSQTSKWILFGTSALLYLCATLNVVASLRQELEAFIMVPPDAHPSYASLYYATQSHSMAVIKTSTYTVAILIQDLVLTWRMYIVWRSDWRVVVIPLILQLTRFSIGLAGIILLAQPGADPHAQVFKTLSSISWPVELVTNVSITAAIASRLWYTGFKISKATSQPSRLNTYIRHIFVLVESGALLVGTTIAMLTLYNLENPAALSIMDIATQIAVRPLYSLFHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMI2</accession>
    <name>A0A4Q9PMI2_9APHY</name>
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        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_950754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
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        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
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        </reaction>
    </comment>
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    <dbReference type="EMBL" id="ML145168">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="8">
        <location>
            <begin position="14"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU55441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="36640" checksum="56059A4036282A9F" modified="2019-07-31" version="1">MAQAATFDMARTDNTSLSYWGQGGQGEPDLIDICHKQTYDTVILAFITTYAGSPGSLTYSFGNDCSQAEIDGCAKLGEAIQTCQKNGKLVTVSVGGADSSISLSSDEVAEKFGETVYNLFLGGKDQSRPFGDGVVLDGIDLDIEGGSTEHFPAFVNHMWEYAKEQGDTKKYYLTGAPQCPFPDHVLNQAHFDAVYVQFYNNEEWPCGLLVDDPQYGWKTFNFDTWNTWALNTSLNYDVKIYIGAPASAQAGNYYADAHTLAKVIGAAQKNYSSYGGVMMWDAAAAQVVGWGWRIGTTFFSHLQRLQNSHVRLAFFQFYGDKYGDGHEHRHGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PML0</accession>
    <name>A0A4Q9PML0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_933709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PML0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8669" checksum="7DA59445AFD760C0" modified="2019-07-31" version="1">MPHDTHSGHIVECYDVSGLRYAILLHPLECDGVQPYEDIRKMRRRQGAENMRAPCTAQIDCRFPMGASDTKSHIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMT1</accession>
    <name>A0A4Q9PMT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_770255</name>
        <name evidence="3" type="ORF">BD310DRAFT_788396</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMT1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="41"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="194" mass="20591" checksum="7EF16BDCC87D16BA" modified="2019-07-31" version="1" fragment="single">MLHATWLKNRASTRALGGKTPYEARYGSPPDLRGIRPFGAKVFVRLEKAPKMQSKAREGHFVGFADNSQAYRVYWPDRRATASSTTGEPQIASTEGRTPSGRDRATPAGPPQPLPTFQNVGDSPGKAPVPLSAGPDSPAPGASPPSVPAEPLEGVQAEEAAPPEEAMGRGRRIKKPSPYVRSLAKGEGTVDGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNF9</accession>
    <name>A0A4Q9PNF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_883753</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNF9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNF9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="537"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="562" mass="60160" checksum="E9B4A0668A183079" modified="2019-07-31" version="1">MSVNADSSVTSVRSSAKKDLRRESDAMSEASTRKHGQDTHAKRSMSKDVILIGTVTLAMILNIANMTAVSISLPTIGKDLNIVESKLQWIISAYALSSITFIIGCACMGVFGLGCGFAQDEITLDILRGLQGLGPAASVPAALGILAHTFPPSPIRSIAFATFAAGAPIGAAVENTIGGVLTQLTVQSWRSTFWFLTGLSALCCVGGLMSIDADIPYALPDKRIDWLGALLVTSGLVFIIFILSDGPIAPDGWKTGYIIALLIVGVFLLVLFVVWERYLERMHARGEETSQRWWTPPPLMPVSIWGRADGKLAAMLAIAFVQWCSFNTFIFWVQLYYQNYLNLNPILTMVRLLPMSATGIICNVIVALVVGRVPLVWLVVIGTLLTGASNLLFAVTVPSAPYWAFGFPAAIITVFGADFVFATGTLFVARVCLPHKQSVGGALFQTLTQLGTSFGLAISTVVSNATLKSKAKSLGVALNAGGTNAPKPAQLTAYKDAMWSGFAFGMFVKRAFEADWCLCACVLLAILFLRGVGVVGHRKGDSDDESEKTALEPEDRDPEAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNI7</accession>
    <name>A0A4Q9PNI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_933001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNI7"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="16411" checksum="FBEC867EE71B0628" modified="2019-07-31" version="1">MSTSTTSTSFSSGSSLSSATSSWSRSLPHPPAPCTMNATANPSSSRTPGPLPATPSIAALPSLAHSLSAFPTMTMVTNDMVHYGNLGRTKGASEAKLNSALRITQQRQVSTAAPGALAMMSATSSPASRTLTLARYPTSEDEDAVLLLVPKRSKAKRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNN7</accession>
    <name>A0A4Q9PNN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_775726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNN7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNN7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13540" checksum="0D5A15CFD69D3D69" modified="2019-07-31" version="1" fragment="single">EIPFPNRPWTRYITYIVGPGLRAADPESCFTPEMCVPMFPATSHPNQRAPLHPKTPFPFRNCYHWAYTDLLLRVSTGGYPRRDDPRVTTLPGRERVRMDTLLTEDLDAAVLARRERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP20</accession>
    <name>A0A4Q9PP20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_824630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP20"/>
    <dbReference type="OMA" id="GQPPKTC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="24391" checksum="08B3775F2CDC6378" modified="2019-07-31" version="1">MVAIRDLVATATAGYLASGYNCPINNYVPSFPSNQTTLVAPSGEPNFLGLAFGVQNYTCSNADTYTSIGAVAEIIDVSCIASTSEFSTIQNDLYTVWTQLVPVSIQTVIDTFHQLNTPIILGQHFFQPNPVTGSGLSPVWDFRSNPRFAGNRNAYVLGAVNGSIPSPTDPTDDVAWLHVVNVQGDLANEIFRYDTVGGQPPTSCTSGNDTDISVKYVAKYAFYGGSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPE4</accession>
    <name>A0A4Q9PPE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_960358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPE4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPE4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF213">
        <property type="entry name" value="DEPENDENT OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="522" mass="57916" checksum="80EF8B42EB450EDF" modified="2019-07-31" version="1">MGALVSTAKLFFYATLQLRKTFEVLKKRIETSPGLPVHNPTLPLWTVPAAQIPQEDHGELPEYADVVIVGSGITGTSFAYNALTSPGLKVVMLEARAVCSGATGRNGGHINPPLYHDYMDLKEKHGEHIAKVMVAFRRSHITEMQRIASEEDIQKQSQVRETEHLDVYTCPTVFAEAVENLAKWKAEMPLESSSFVVHEREEAIKKYHLSDDVVGCISNTGGAMHPYRFVTSLLSILLDRHPNNFRIFAHTPCTAVTTDASSSSYVIHTSRGTLRAKHVVHATNGWTAHLVRPLLTKIAPARGNMSAQRPGTALHRSTLSGFRSFVFYREGVGYDYLTQLPSGEHELMFGGGWATACDANGLPEIGIADDSVVNHVNQSYLAGALPRYFGTRNWGRDASPAPEEGEIWGEERTKAEWSGILGISADMLPWVGRLPEKVSGRAQPKTLQERDKSVRTAAPGEWVAAGYTGEGMVHAWMSGKALAYMVLDRDEETREWFPDVLRVTEKRWKEAKIEDLFARFMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ92</accession>
    <name>A0A4Q9PQ92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_613975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="169" mass="19376" checksum="B8B8FD33D29B5C1B" modified="2019-07-31" version="1">MWIWVSLRCRSPHVQLKVYLHHRFMMYMERIQAGHGRRRCDLTWAMHSARLDLQTHRSVDIHIASQNSFSNSTPCIAPFRIISWHTRGFAMQQVRDQRTGNVNVQDAVRESIVETLSAPLYGSVNVIDVCLDASCMSQRVNSCLSDVLAWTCVPCLLCAWLVVSIIYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQJ0</accession>
    <name>A0A4Q9PQJ0_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQJ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQJ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="39574" checksum="9200280F62018AB3" modified="2019-07-31" version="1">MSVYAQLLSLPPLSSLSSVKDIFGSVFIGAFLSFSLYGLFVNQTYTYFRLYKTDAPWLKIIVRFLSVLNQLCSLTISETVVSALHLHLGYYYFVENYGNPLAFISGVFPVVSASIMINCQSFYTVRILLGMCNFGPSKFRVLLVIVVVSLMCGAMASHIDSCVLGVSIGMFRGITLINFNNFLWLALSYNVLASAADVILTTTLIYILHRSRTGFKSTDSMINKLILIFNIISFVLVHIYGVGNWSWLGTMMIAERRELNSRKLATKKRENDNVTRPAELYGTAVRASTLRFNRSSGMGEAIELSQVHPDMIEVDERRYDEEDTTTQLGATKRFPSWPRLTLNNHQDPLPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR15</accession>
    <name>A0A4Q9PR15_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR15"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12094" checksum="C837E866A9AABA28" modified="2019-07-31" version="1">MASVLSVACTLRLLVSRSCPIWQTPTLLVSFPALDRISTHCCPLPYLTSHLTSHHKRCLSLDSVVLRCIIAISTIVHARIPLYFSPYPSCTFTTPRCPSCRLSVPYPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRS0</accession>
    <name>A0A4Q9PRS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Senescence domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1040126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRS0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRS0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="262"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Senescence" evidence="2">
        <location>
            <begin position="477"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="575" mass="60193" checksum="6F6CF61F1823D11B" modified="2019-07-31" version="1">MATHPEAFVLLHIPEVSLSTSNTSEHGTLALECVTLATDSTDKDAPLAASLSASDRSLILVLRLGTLELPLDPARAISLHIAADGTRTYTFHSDVGQPGVPPADKESSFIRLTVPIPSRPDTHRAESVEALDHILAQYADFDWETEGGPYHDAPPHEDGTEAPNPTQEDLRGKLVLMDEASGEIVGELPNRVNIKEDPALADKEKATAKDGEPAPVMVELPEEMYDAYTGHGASVVPYVEPSSELEEAREIFVRAIPPEDQDWMTKSATLISQAISSSTSLLLHGLTSATNYYIGHSTPSPTPKGGVPPPPQPRALLLLSHPRTQSTLSSAYAISGQAVKVSSKTAAIVEDLIKRAVGATIDKGKSTAGPPVPPRPQASTATSAASVPSVASTGPPPPYPGAPDVRPPLPPRHSAAPSAAPSAPGPAPPLPPRGKSPLPGNVPGTPAKESLPASGTSTPASTSSGKPVGRSGKLALSANLILATVDDSLRRTFDVGSERATAVVAHKYGPEAAKSTHLATHTARNVTLVYIDMRGFARKALIKKAGKTWIQAKLGGGREMSGVVVDREAQSKKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS24</accession>
    <name>A0A4Q9PS24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_907304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS24"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="79"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13643" checksum="4FAA55CE68F36FB9" modified="2019-07-31" version="1">MPSLSTGTLALSISYLPSGRSAFYQEWVVWILSSKLRPVVAIALWVYDEAMSVKLFQAPSVSSLYGSAWIISVASAVQMVADMMITSTLIYLLRRHRTGFRRSNSILDTLIAYVLSTASSASLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSB1</accession>
    <name>A0A4Q9PSB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_821938</name>
        <name evidence="1" type="ORF">BD311DRAFT_739500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU28185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2729416at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="215" mass="25393" checksum="302CF85D1A48818D" modified="2019-07-31" version="1">MVSQNPALWENGQYLNEWDREHNDRYSEAAKKAQEAKWKRLMANRPPRDALPNKLLPRPGQKLPLYHYGFPFTYKYAIEYARRHHLTIPLAEEDRETFGGQAVLDMAELDDARLAADEDIRVFAKSVSRNLMVRDLSRRCGYTLDTGRPFSMDWDGIVSLWTNYDVEERFVWCYDHKKVVDILKGAMNETEWHNSLKAQWWFDWDNDVGLFTSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSC4</accession>
    <name>A0A4Q9PSC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_562001</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
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            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
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            <begin position="18"/>
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            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="21370" checksum="5F123B6E8EA7C094" modified="2019-07-31" version="1">MSYLAQFAQLLTNAPTGPSSQSYPTSHSPTSPTSSTSSLASSSFPACVLTSSTSSSVHIGAASSKNPSSATPSPGHHDRSSNQPTSKVNSGAIAGGVVGAFIFLCLVAVGALCIIRRRRKSRQPPSAEFMHIARGQSELGFVPTDGKTTPSLARLIPLARQSSLEVDERPPAFTPGSYGDPVLEKVQASAELREKYGGTSEEGGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSI9</accession>
    <name>A0A4Q9PSI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1039911</name>
        <name evidence="3" type="ORF">BD311DRAFT_769599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143523">
        <property type="protein sequence ID" value="TBU22869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU57371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSI9"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU22869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="345" mass="38900" checksum="1A0CDFA60AC0D0EB" modified="2019-07-31" version="1">MSGKTKMQYVRLGNSGLKVSRIILGTMSYGDPSWDKWLIGEEEAIKHIKFAYDRGVTTFDTSDTYSNGLSEIILGNAVKKLNLPREELVIMTKIYFPVASDYGTHTYFHNPHDLGIINQLGLSRKHIFDGVKASLKRLQMDYIDVLQCHRFDTETPISETMRALDDLVKAGLVRYIGMSSCWAYQFHQMQNYAITHNLTPFISMQNNYSLLYREEEREMMPTLELFGVGCIPWSPLARGILCRPAEASTTRASSDPAVAMYQVPSAIEIVNRVEEISRKKGVSMAQVAIAWVLSKPGVVAPVIGATKIPNLEDTLDGIDVTLTEEEITYLEEPYKPMPTKYISHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT47</accession>
    <name>A0A4Q9PT47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT47"/>
    <dbReference type="STRING" id="114155.A0A4Q9PT47"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="819"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="944"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="855"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1123" mass="120521" checksum="665495764E308B27" modified="2019-07-31" version="1">MVADAKSLRIACRHVCTDQWLVTHVDPSWTIASLKLFLLHKFSRSASDPDHNPRAISVSPRKARRRSLSPITFATPTLRKAQPLYASAPSSGESSDTEHSGDLDLDLDDDDDVNITKSFTDAHRYKYNARPSTSSTSDSLSTARLPLLDALTSSSASYDVNAYILLTFSTTQILEDRFSLSWYGIHPGELLELHPAGVSFVALPRSTLDAYIAPYFATRVWALRIVGHGSDEKEDESLDVRTPNLSQKREKKKVAVEWKERWAIIHQGVFSLCKERHDTHAAFSSPLSSMLSIRDSAHFKIPLHTSRIPGRYKSSISPASSNIVCVKFGTGRTPRQRTFSNESSVTFDQPPSGPSFTSTSISASAGPGSGGGQGSWWRRGSRDVSTTLSLGLTSSASALVGSAFVGSSSNGISEVWDSLARRGSRAGIDESEGEPGSSREKGKAKERDEAEDAVWIVLDMLGSSACSHILRILHRHAPPQCNSTFLPGRGASIYSPSPSPIIFNSRPSTPGSPTTPGPTSFNFPPSSSQLHSQRLSQAPLLSPTALDTSAPYFPYKSYHFGQGSSSDSRPDTPIVPLPGYTLPDLTIGYSEGVPYPFWRLELVRDARRAGLGAVGRAMELVMFGEDDEDDDDYADDEAAEEEDDLAIAWARRGTTSSLEISSVVEQPSPVDTDVQPGGMTGRHGSNPSVPSDATLPEGRALQSDADPPSDHVGPQLEIESPASPASAPDPAPTTRPHRASHPLVDLTSLHEAEPPVSESDSSEAEWDGWVDAVVAQYRRESLARRAQARREALAASASVPVSASTSAAPWVEGWTSQYGGGESSTNVASPDRENADYSELGTWSWPGQNQRGSDAEGSAEGSSHSQHSSDPQAPPSAYTARRTTSGEMRGRGHGRSGSAGRTLSTYSSVDSSLRRTVTMRTNLNSIGLNQLNRSSMQAAFSSASSSDVNLAQDSVEVRRSGSASPPPPHARLSRPSIASFRSASNVNVRNHVMSPLSTQIPDEDPSAGVDYFEPDVDDIEEVGNNEDVYENELGHGQVAGPHPVPLPGMRMAPSGYTTFRHNALYGGQANEKKKGGKERAQVHAGVVHGQSVGRLPMGMGSMVNTVSSTVSVGPSARRSGRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUX4</accession>
    <name>A0A4Q9PUX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_819550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUX4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUX4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF82">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020475597" evidence="3">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="264"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="281" mass="28538" checksum="D16D31D0D3E0ACBD" modified="2019-07-31" version="1">MFAKLFSLATLATVVAAQTSNVTIAQVAQAFSAASIVPIVIPTFNPTGLLGVVFFDNTTNLNVTVTPGQNLTREQNALRPTVSFTSNDTSLASQTFVLAMVDPDAPTPQNPTEAEIRHLLAPNITLSGSLADGALLVNNTPAISDFLRPTPPAGSDPHRYILLLFVQPANFSQVAPNFVNASTPVSNFNISLFAVEAGLGSPVAGNFFLTGPDNTSTPASGSSSASAAASTNTSPSGSAGTSAGAAASSGASNAASMMMGMEKLSVVGITIAMCIMGMLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVF5</accession>
    <name>A0A4Q9PVF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_819034</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVF5"/>
    <dbReference type="OMA" id="NQCLQAC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU58612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="216" mass="22116" checksum="C74731776C92F0F3" modified="2019-07-31" version="1">MHAARAFEAPAIPLNWTTLSTCAVDNPARILAGDVTTVTEDNSPAACITSCAAGGFGYAGVEFGDECHCATGLKAPLDEGTAAVCDMACPGDANLSCGGVWSIQLYTVPALRPGSWAYQGCIVDTVETPAFATVTLQNLASNLDLVNQCLQACSHAGFSFAGLENASECQCSNEGITAGATKANETDCNSLCPLPGDAGFEICGGVERLGVYKFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVX3</accession>
    <name>A0A4Q9PVX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_819102</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVX3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020601736" evidence="2">
        <location>
            <begin position="19"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="68"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="446"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU58640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="557" mass="59721" checksum="7F40FF6C8567A3D5" modified="2019-07-31" version="1">MKRSLFSLVSLLIAYALTAPSAPAAPKWEFNLKNETSGIVALEAIVVSPTLVVFFDRASDDPLQINNHSAWGALWNLETSTVRPLDVLTNSFCASGALLSNGTMASVGGDPRGFVGNPAIQPGNQAIRIFEPCASPTGDGCTLFEDPATLHLLAKRWYPSSIRIFDGSLLIIGGTHVNADFYNIDPENSFEFFPPKESIVRPSAFLERSLPANLFPRAFALPDGKVFMVANNQSIIYDIEANTETILPDIPNNVRVTNPIDGSAILLPLSPPDYTPEVLVCGGTATDPLDPSLLSSQTPATSQCSRITLTSEGIAKGWEVEHMLEGRTMPELVHIPNGQILITNGAGTGFAALNQVPDAIGNSNADHPVFVPSIYTPDLPLGQRITNAGMPNSTIPRLYHSSVTLTPQGNFLIAGSNPNGNTNLTVPFPSTFKVQTLDPPFMQLNRPKILSTPKNLKFNSSVTVPIDLPQELTRPGAKVQVALMDLGFSSHAFHSSARLVFMDAKISADKKSLTFITPPNGRVYPPGPANIFLTINDVTSEGAWVMMGSGNSPPTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW73</accession>
    <name>A0A4Q9PW73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_453336</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143549">
        <property type="protein sequence ID" value="TBU22278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZG0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZG0"/>
    <dbReference type="OMA" id="KNAISIW"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597654" evidence="1">
        <location>
            <begin position="31"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU22278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="382" mass="41239" checksum="E1AA34AFEDCE8063" modified="2019-07-31" version="1">MVFNFKKLASIATLVTVMSTLCTYPSPVAASPLVPRAQCAATLSTAASVGSRLQSKYWNGSGWGIFWTDANTIEDFYNLMLADGSTTFDVADNTRIGQLALQQDRNAWISALNGSNDDAGWIVLSLWKVADYRSTHGQNAAPYLNSASIVYDLIAAEWDDSVCGGGVWWSSAHTYKNAITNELFLYISASGYNRFGNANYLANAKKTWNWLLNSGIRNSQGLWNDGLTSSCANNGQTTWIYNQGVIASGLGALYKATGDSSLITQAETTLDATINHLTVNGILKESCDNANPTSTCDNDQAMFKGIWMKHLQFYLDNVPDRVSKYQSFIGAQESAVVHYGTGSGWTVGNVWYAPSNGGSLFTAETQTSGLAAHVSAAKYGPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0L3</accession>
    <name>A0A4Q9Q0L3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_814822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0L3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="778" mass="87643" checksum="30C1F6C8307BF6AA" modified="2019-07-31" version="1">MDNPGWHAFRRADKDEARWSMPHRGPDGRFQPVEEVGPMAEPFVGGFLPPPSPVPSLGRGPPPPLPPKDGNWDQLNVRLPSKASLSDTMSRTESTLSGANSTYSTFANMSAVERSKHLRVARMNPHLQYMVGPLLRYDTVDEQGVWRGAAMIVTADAGSVYEPLPTLTYHWDPDLTPSGSQLKRHVSSRTHGQSFDLGPHPADPMSIVTPGSPTRENETYGNGHDAHVERRRVEGKELYVYYGNGGQVSKSLVRYAQHLTWNGTHRTFTFWRFMIEIPLTSHEMRINYTINDGIELNFHVPGRNQNMRWAAYSCNGFSSGVNPDDFRGPGYKSGYDPVWMDLLAHHAEEPFHALVGGGDQLYCDSIVREPEMQDWVNQTKAENKRHYRLTEEMALAIDRFFFNHYCQSFRSGAFARANSTIEELVSVRSGSDTPLVKIDGFGSYPDDLMRSSVFNTIGSRGYFFFLLFQCFINVEVDGRDDRRHPFKSLVIGGDGPYIPYPSHSFLCYLGPHVYMLLLDCRAERKKDQVCSQREYEAVFARMKALPSTVEHMVIQTGIPIAYPRMVFLETALDSKFNPLVALGRNGSLGLSGFVNKFNADAELLDDLNDHWTAKAHKKERNWFILELQKYAKATHVRVSFISGDVHCAAVGLLKTFVKDKKRGDVPPPLDPRYMVNVVSSAIVNTPPPNGVISLVSTLASKTHRTLHHQETDETMIPLFERDTDGSAPKSRYIMGKRNWCSVKWDPSSGDLIWDIRVEISKGNGQTTGYAVRSPPPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1A0</accession>
    <name>A0A4Q9Q1A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_815672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1A0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1A0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22916" checksum="B4D81AF7492AFC71" modified="2019-07-31" version="1">MPVTLVFGDAEATPDEAARNVFEVDFWGAVHVSQEAVRFFREENSPQGGRLIQNSAAVGLVTREGLAFYGAAKHALEAFTETLSKEVNSAWNIKITSVLPGGFVTDITTSGQLIPQHPAYADDSNAVALVRKMFIENASMEAMNRLGCGDPAKGVQKIYKLSKLPDPPLRVLLGRDSNYMVKEWHTQLGRETEEYAHWSDSLGFEVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1L3</accession>
    <name>A0A4Q9Q1L3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_815273</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M35 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1L3"/>
    <dbReference type="SMR" id="A0A4Q9Q1L3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1L3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029463">
        <property type="entry name" value="Lys_MEP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14521">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01351">
        <property type="entry name" value="Aspzincin_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020736382" evidence="8">
        <location>
            <begin position="19"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Lysine-specific metallo-endopeptidase" evidence="9">
        <location>
            <begin position="209"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="374" mass="40377" checksum="D4222B43DE96544C" modified="2019-07-31" version="1">MFPLAFLSLLTVVATVIATPSLLLEVSGPSTVYGIDNFNITTTVTNAGNEAVRLLNHPRGPLSDLPTDMFTITNRHGFSPDFVGISAKYSPSAALASNDRYAFTVLAPGQSVEVHHDISATYDFSTSGPGQYVVMMKNFNTFYYVADGKISALVGGSGHAFHTINVVGNARSHKQRIDAHTGGHCEIWQKRAIDAAVPLAEKYVRHALEDLVKGGPNSAEYKRWFGPALHGDRHTSVFSHFETLAGSNFSEYAYFCNARFCANRPGVLGYVVPNHFGAISLCDSFFNAEVGGHNSRASTILHEALHFSKNGATDEHAHGETLGQELARSYPHLAATNADNYEYFAVAAFGDGPGQGDASVLLTQVHFGKHILDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1Z8</accession>
    <name>A0A4Q9Q1Z8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_921515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1Z8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="192" mass="21960" checksum="483B214F10C4DEAB" modified="2019-07-31" version="1">MISYVSCAPTTFPVILHQLLTSEFLKIVLYRCATYSQQDTSSYFPLDCDGFGHSSLQDTTLRSLCGRMRFRQVVQTRLDNVFSTMKRFARRRGTTQVSCVGAKMRVECTSKKNPNTVLCKKDCSAKRAKSCLPLFAHPGKRLQCRKHGRFPSHKPTGYIQKVVIRRQRISSCIFVVGKRTRTQARLLRTESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2Q2</accession>
    <name>A0A4Q9Q2Q2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_814679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2Q2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17427" checksum="859F0970312AA667" modified="2019-07-31" version="1">MPCSASCSCPIQLRFHILASKEQPTMPKRLRACSASSIALKLSSVLRAAAGASGHYQASTLRLWLWLLPRPAPPGFPCAEYRFAHAIAAILVDHARLAAGPRWSQPRVCILHPKHTPDACSCPPPSYPLQPVPCPQFSRSYRSAGTRRSHTHDTPAHSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q345</accession>
    <name>A0A4Q9Q345_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_813643</name>
        <name evidence="1" type="ORF">BD311DRAFT_676937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143560">
        <property type="protein sequence ID" value="TBU22042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q345"/>
    <dbReference type="OrthoDB" id="2755117at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU22042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="154" mass="17093" checksum="D2E3890E247FD802" modified="2019-07-31" version="1">MLVDPPYPSFTLVMIAADPSLRLPSYRSSHLGRFHPYPRGGSRRSEDRDIFVNAYMYTEGSSTNVPAQPCLRPARRCVEVPDNDVSSFELDPPVVGVEYDEYELRAFSGVPTGLSRSKLAEALADLLGELRRRCSQLTLGTLFGTVKSGVERPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3V4</accession>
    <name>A0A4Q9Q3V4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_965715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3V4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3V4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="876" mass="96824" checksum="6F4525A713A960E0" modified="2019-07-31" version="1">MLPQLLLSPNRPPLAMPTAPAQDQSSTAHLQVVRILPIPTLHHIARERPVTFPRYRTMKTAHLATCTRDARRGYLFGIPGFQQLTAKRFGLVVNDALRGRWAGPDIFSDLVEDAIHVCERQNVLKGRFVITLVLRKLAIAQAITKTQILQLLRTLEAHDGLRFVPTESRIFIARAVAAYPPDQTIDGELFGLLAPWLLRALPEKPAPSTDKPGLWEESSTGTRVPRVLWAIYRGILSLAQSREQTGASNLLAKLVAGSHVGNDAINATNLSEKDYIYIVLSVLVRTCLSHGWVSRAAELLMPEVSARESLSPALAQLLQDWVAAALGDPREQDLKPAAHALILLFQRAEKFQASTAVVQEFYDAAFRAKMPEVVESVYRAARKIETYPYPPPRGQALLYFMRYLLQNSRNVHLARLLAQQIVEEDIPLPPTVRGDFISNIAVFGFTSYARALWERYSTGPDMLYVVGRRAVMLRLVSAFLKAEAIVMRTVRQRWPSEPTVAPRINQLDEAARRVDDQDEDVQASSSETRPDDRVEEDHPASDAPHPAASPPPHGIADEDAELVSGLSSDADDLAAPTGEDGSGRRPLGFAALTRSELLERAGDLRRFAERVFDAYVACKPPLEALDHYGLNALARGAFMLGRDQMAFEVFSAMKKRGIKLDMYDVNVALSVVAKADPAAGFARIRRMLASGFKPDAATYGTVIHWAVYHGDAPLVGEVLRFARANGLKNFSFKTMGSLLHATVSSQFDSLTTPGAQLDNARGIVDNMFDVGILPTVNMGRDCVIAALRAEDPVMAFSFWKQLLRGKVQYTDPAQAALRRRIVYQIREHYSSGWLDEKRARAMLSELGYPSELPLHVKQRLGAGAPEIDDAGPLSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q468</accession>
    <name>A0A4Q9Q468_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cleavage stimulation factor subunit 2 hinge domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_946151</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q468"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q468"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cleavage stimulation factor subunit 2 hinge" evidence="5">
        <location>
            <begin position="5"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription termination and cleavage factor C-terminal" evidence="4">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU62097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="22329" checksum="00C0C529830FFBFE" modified="2019-07-31" version="1">MAAPTIPEEQLLELLLTLKRTTAAEAKAILNQQPQIAYALMTVMVNINAVKMEVVQEILAKYGALPGAPRAPQATAPPAIPSQPPSAIPPHMQAQIPPPRGATPTYPVHAAVPPGGYPPQSYPSGPPAPPAAPNRGYGTPPPNQLPGFGTAPPPPPPAPAPAAPQLPDALTGLPDDQKALIMRVIAMTREEVYAMPPADRENIIKLRTTLGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q791</accession>
    <name>A0A4Q9Q791_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_577320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q791"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q791"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="41"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="477" mass="52440" checksum="57B167459CE4D20F" modified="2019-07-31" version="1">MMSAIPSPAALSLDFIVVGGGLYLVINPFNESRAFPDCIGGLAVAYALSKAGQRVRVLEKNNLNVPSGGHRMTPNSSKILRQWIGEEELMKSAVRCVRCKTFDLRTGEAVGYIEWKPAVIAETGGDFLLMHRNDLVRILHRLATDAGAIVDFHAEVTSVQQGTEEDPKPAVTLATGEIIKADVLVGADGCKSLVRKVVLEEEDCAEPVRMTLYTGVIDAKDMVTDPDLAPYISSDEWAIGMSPGRCMMGHPVAARTQYAIHLFYWDKLDRLPQGGEESWEDLCSIDGISTSDAYGPAFQTMLKLTTNLIRTQWKNHENTVEWVDSTGRMVLLGDAAHPSFPGGTHSISLAIEDAVVLGSLFSHLSTIDQVPSFLGAYQELRQRRCELVMAADVSNARMMTFPDGPLADKRNADMRAKNDDWDEGTLKAQFEEIAEIFAYNAGDAAEEWWVNWGRFSAAARERPSMMNIFSGITKCQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8P0</accession>
    <name>A0A4Q9Q8P0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_944935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8P0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8P0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="45505" checksum="865A71BCF77405E1" modified="2019-07-31" version="1">MQVSKHHTRHRSASADPFNDPANVSYSSYGIPTLSRNAPPYPAAVQPPPPPPKHTAKPHSSRPSTGNRQNIMDAVRDTVTVRGTPDQIPRARVARSQTELPPSDINALHRLPAPFPFHLLSQPHSPTLVRPSTAPVSKRSQSQDSVVRTANAMEKAKTGRKKKGSSHADVIDRLDFSGVGPMFHHDGPFDACAPSRNRHRTKAPMLAWSAGHEADQQALNNAQPIQPRSPDVFIPYEAPKKKNHDAIAEAWGIHEPEPFEDFSAGGGATARQSGEHARSGNGSSRRTRDGRDARDVYREYLEENHPSPARRAAKRSIPPPQPIFVPDNELGNNPPSPTSAGYDSPGGNAPRRNKSLMQRIRKMRDQPNVPVGAYDDDGGRRDMSPGPSGEHHRHPQYYPSQQARVPSRPTHRSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8S3</accession>
    <name>A0A4Q9Q8S3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">N-acetylglucosaminyl transferase component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_916343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8S3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8S3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="585" mass="65299" checksum="6772076573E7B8C0" modified="2019-07-31" version="1">MNPMSAVVLWPADLTDLEGICYGWKQPLVCVAGVIATTDSAEAERMVTLASLRSEWSAVRQMFSSDPVVLGHCRSRSSEGRSLEFSFLDDSQNLEVGQLLVYRRHKRSSMRFYSFNFSELDILPSQESEGSDTRNVVALANESLAADFTRLGSSPKRKGAVFDAEVLSQANLAHLLAAIVEKEATSSDAPSNPSAGAPEPTGRGESPPPSRTTPITPSSSANIIATIYGASRRFSSTMEQCDIRYEQGLYVSREVSYVYKDKARTVHSISKYIKFHNCVWLVLNDVIIGVAFGSFLCENKQFFAQWLHYGLQTYLIDGMREALLWLNSWPAGLKLNTELSQFYCHSLVGLVSVWGWLLEHAAPCFPALVWLIGVGGCCGMTMIVSLLSDSLGLLMAHLYVCYYLSATVFSHQLGLAGSLWNLFRGKRYNVLRNRIDSWDYDMDQLLLGTILFTLLAFLLPTVLTYYALFATARLSVIIVHAMFDTITALLNHFPLFALLLRLKDPLRLPGGVFIQRSKTGPLLLSSQPAPLSSIFRHYAHLARRLITHYHPLRMLRQLASGRLLSPISREAIRYSMVPTEDVLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9T8</accession>
    <name>A0A4Q9Q9T8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_944911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9T8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9T8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="294"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="342"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="546"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="572"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="859" mass="96088" checksum="7359FC6EEE44834F" modified="2019-07-31" version="1">MTIFASNEVSTIGAAAAAEDDDDDPDYVDEEEDEEEDVGYYTYGLGSQAHSRPWNRSEWWPKRTEPQKEGLELLYSGEFGRLLHQIQAREGQHNVARNLLNRGTNARPTPKEDITCEILPNSSGTAVASYPANAYVGQFSSDSAFYYTCVRNFRLHVYDMTAPIKHTVGRQLAQESSDGHATTMEVIKTIQAAPGRWTITDSHLSPDNQRMIYASISSTVYMCSTLDASTEQIPISFRDPAPSRGRRAWNDWEDDEQFGIWSCKFSADGNEVIAGGSSMIFVYDLIANKRTVKISGHTDDVNSCCWADTASGNVLISASDDTFVKVWDRRSLAATRKPSGVLIGHTEGITYVSAKGDGRYVISNGKDQILRLWDLRMMRSNSEFEAVAKQDYGIPHFDYRGDNYPRPRYRQHPLDCSVMKYTGHEVLRTLIRCHFSPVETTGQQYIYSGSADGKIHIWSLDGRVVQVLDRSHTLSMALDPSAPEPVDITPSRIRPCVRDVSWHSQEPILMSTGWLGRRWGLSEGSVIARHEWKGLSKLRNKLEDYVEKQKSERADRAQRRAVRRGTMPGSFEPASPASPADASDDDEAAMQTVPPLAAELNTYGFPQGYFMLRSLGTNRVLDVSEGLSDDGTPIILWPMNETSLVESMRRPDCDNQVFFIDTSGALCSRSAGHAIDVQDENLVIRHRKPVTYPFPNAESHPLPRFAYYPDTRELTVTFAYDPFYPASPTSRRESTSSVWKTKTYYLSSVPLRKPPTLIDNASALLNSAVVGGMSLFGGPKTNATPEQVFDGQIDLNESEIAEQDRNEAEEIDDSPNWLRPVKAIGLTAEEAASATEKAKLRRQWEILPLRHTRRLTAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAI0</accession>
    <name>A0A4Q9QAI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1001215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAI0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="198" mass="21092" checksum="CB0FCFF46909495C" modified="2019-07-31" version="1">MQSPTKSSSMVPGISPLALPVPRSLGVVCQVGLTDLGGGSPLSRQPLRPTETMATASSLPRNTRSLGQAMASSPPLGGHHGCTDGRGRSSIPSFEDLPQFCVHYAKNPVGNSRQGGWGDAPKELSRSIGFVVVPLYPNIQEHFTGWSQCELCANDLCLQVQQSFILLSMSDCSGKPPDSLVPDTGNRHAQHWFVSLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBB3</accession>
    <name>A0A4Q9QBB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_954465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBB3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="431"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="980"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1225" mass="138979" checksum="667B876CBB4CBB29" modified="2019-07-31" version="1">MEIYMKNIPASTKDTKLKLELAAVLHAPPFRNPSEELYNFGVFLIQQRKRGPWRTGFLTLPSNEIAELFLQTYGGPSPRHSFVLDTTRVQFQVSNRGARPQVLERIRREPFQDPREAFAREQREAELQALQVRISTIQFGWECRDQVYSVEWETACHARLAFDGERREFRVRMDQGGLFSDTRIIAIRVSQIYYISATVDNDSRRPTIVFSLIHPPALESESTLSQLASLFSSNAKPPRQRWSSFNDSDDLAAIMPYVSLSIRLECESVEDLRNFREFADAAHTRVGSDLCPVERRGLFSDTVREDYSLWIQRLPWTVVFQIEALLRSWLLNMREALSLRDHVERVLRAKGRAYTAALLRDFTSHAKALYWYGEAQPGAEPSLQTHLNASWSDPVTHLFQSVEAQFVYKPVAAHAPAVDAPATFQCFHVSITPTTMILEGPFPERSNRVIRMYWQNEECFLRVSFQDENRLQFRFDREVDGRSFINRRFRGVLRDGITIAGAHFSFLAYSQSALKEHAVWFVKPFRHRDGHGVEHYVDATTIIENLGNFRVSFDTTLIHCPARYAARIAQAFTATDASITVDVDQIERGEDLEDATGNYCFTDGVGTISRELARDIWRSVRERGRRSRPDRTYPRAYQVRFQGSKGMLSVDHTLSGRKIVIRPSMTKFEANQSSTIEVARAFDRPGPYFLNRPLIMLLEGLGVSYETLQALQDAAVYDAQQSVTSLERSARLLEAHGLGVSFRLTSAMLGLHKLGLDPLNDDVFWRQAMDFAINHVLRELKHHARIPVPSLDSWTLVGVADVHGELQDGEIFACIDSPTESRLIYLEGPCLISRSPTIHPGDVQVVHAIGRPPAGSALAKESLRNAVVFSIQGERPLPSCLGGGDLDGDLYNVTTRRDLLPPRTYTPASYEPAAKKLVEHECTMEDVADFVAEYISSDTLGIIATTWLKIADQSADGILDQDCLKLAALHSHAVDYPKSGQPVPVNQIPKLKSKTKPDWSAPETISRGNEDYYTSMKAIGKLFRSIDLPALQTVQRVARRQRRHMHNANQDDEYADVLELLYDETPMDDRTAVAVQERISEFISPEEYDGDFIRRIWDLYKSYTSQLRAICADHTLEHKRSAMLTEEEAVIGTIVAKCSQPRKRKDLMSQMREQTATLVSSVKEELSGDDEIPPETSLQRAWIAYKLANIEGEAFGARSFCWVALGSIFDAIKEIEDEDRALARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBF1</accession>
    <name>A0A4Q9QBF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peroxisomal biogenesis factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_913647</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="TBU64915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBF1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBF1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF50">
        <property type="entry name" value="PEROXIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU64915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="246" mass="27604" checksum="EC65992E1446AC18" modified="2019-07-31" version="1">MSSIASQVILHPVTSQSLKVLSTTIGRDKLYRAIQYFARFFAWSLLARGYKIQAARWDALKSHLALGRKLLRLGKFLENAQAALRAISAPGETGERITAIGRQLGYFGYLSLDNIGWAHSIKFYNLAPSTAQKINKRAMQFWFTGIVFSIVHGLLKAGRLANEVKQLQGQAWSEKSAEVEREHKLRSLQTAREDVRYQFILDLLDVWIPATNIGLVNLNDGILGIFGFVTSLMALRQQWLAAAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBY6</accession>
    <name>A0A4Q9QBY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBY6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11695" checksum="2825C0BA53415A04" modified="2019-07-31" version="1">MTVGIFGMFAPPLFLVVPRARYAMASVCQLRIGARGVQWSKGRHKAIHEVEDVRVPILRRCVQFVLPRLLRCCLHMGAMMAGFRQMFCSPRVISRAYVSSKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCM0</accession>
    <name>A0A4Q9QCM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_839541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCM0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27293" checksum="894D0C31C4F5E415" modified="2019-07-31" version="1">MSYASVAAHNAPPPSQQPHPDPALLTTEPPSASNIADDAAKVNIVSPDFKRHPATNTSIQDIPSDISTPGGQPSKRRRYRDEVEQEGFYLYNLAKQYILHPAVAGGLLGLVNIGLISGAAYKFYNDPYLRRDTRAIVSAVAGAFTLLGVEGYAAEKYRETPRGQREAQKAKKEGAALYRTAREYILRPGVLGGLLGVVNAGVLGTVGYFSWKNWDRPSWDRRVVSAVTVGLLTIWGGEGFVAERYRTTHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDH3</accession>
    <name>A0A4Q9QDH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">mRNA transport regulator 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_864753</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDH3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11371">
        <property type="entry name" value="RNase_PH_MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="46"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="11">
        <location>
            <begin position="177"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="261" mass="28420" checksum="8812308C8BB1301B" modified="2019-07-31" version="1">MAQANFDRRRINGPDESFQPIFDSDEEDETRWKPGKPRKGRGARDIRPIFLKAGLINQANGSAYIETERTKIACAVYGPRQSKTTVYNEKGRLNVEVKFAPFSCTRRRVPIRDAEDRSVAVQIQQALVSAVRLELLPKSTIDIFITVIENDGIQGCIASGSVAASAALADAGIEMLGLVASCSAAVVGEEIWLDPTEEEEKVSSGTLILSGMPALGTITNVWQSGSMAPEDAMKCMEACQERYTDIHAVIAQALLENVQTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDM8</accession>
    <name>A0A4Q9QDM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Scamp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_912100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDM8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055038">
        <property type="term" value="C:recycling endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007273">
        <property type="entry name" value="SCAMP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687:SF90">
        <property type="entry name" value="SECRETORY CARRIER MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10687">
        <property type="entry name" value="SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04144">
        <property type="entry name" value="SCAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="255" mass="28717" checksum="32BD25D3B1BF9FA6" modified="2019-07-31" version="1">MSYNENPFASSHSLDTNPFEDPVKPTDNDTRLEELRQREADLARRERELAQKQDHIRRHGRNNWPPYFPLLFHSIRDEIPEASQQLITRLYQIWLVLAGTLVVNMVACICILASGSSNGGSDLGSSIGYVIFITPLSFLLWYRPIYNGYMKEQALYYYLFFFFGGFHLLFSVYMIIGIPSTGSAGLIQTIQAFTKPSLPAAIVGTVATVGWIAQGVGLAYYYRQIWAHHNAAGHSVEKAKTELATHGAKAYFTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QF07</accession>
    <name>A0A4Q9QF07_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_836978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAP domain-containing ribonucleoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QF07"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="SAP" evidence="5">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00046328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="301" mass="31918" checksum="6D4EC99F7E8A7C1E" modified="2019-07-31" version="1">MHRAALRVPLRQAIASQRRSFVSTVLLTKAWENETVAELRKEARKRGLSSTGNKANLITRLQEDEKKKAFTTAPTSVAPQSRAASTSSAPSSTPGTESATEVPGIPSTAEPTYLKFNLDTKLPDISQDDPEPPVAIPFVPDLWNSSKLKHESAPPTAPPSTAPKLVVIGGEATHSGSNVYTASSSPSPDSVLSVPRPQPKSNVGKLFADMADDLGLPTTLKLPSSDHAHFDAAAKTETSGGQEKSYSRKLDGEEKTGVYVLLGVFAASLVAGGVFAPVSEWAHKVEVKTQDVQEKTVGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFB0</accession>
    <name>A0A4Q9QFB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein prenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_912719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFB0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="488"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="556"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="623"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="657"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU66080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="782" mass="86394" checksum="B7ADF9ED7B06A751" modified="2019-07-31" version="1">MPQDAPPAVLTPQLCQRYSSLVWYFLDADLHKSALFYAERYFVLDQKNHDARHLYATALLQAGQPHSAHKLVNIPLDNRCTGCVDIIAKCCMKLGRHRQARGALDVCLQDPDYTPTQSMSARIARASPDDAIRHCQAGNTALKGNLHESAARSYIRALELNPMLWEAFEGLCAIGDIPPVETLFPVRPMPVLQKSSEIGPSKLSIPVATGAGFFTPDAGNGGNLFRGWKPELRKDVLTGPRDSIATTDSSFYGEPSFQGPVRASRSQPTTLAVQPPAVRPLSSADEAGPVTKKLRSTVRQRTAPPSTKAGDIQHQLKPSKSTGAIPETVPDDRTKSSKTTTASRSNTIGAGRPAAGGSSTRRSTRLQSGGSKLAKTVRDRRRVAAKTRSQSHDSGIEEEPGGSDQPVVAPPALFAQHTHSESSPPTSAAWTAEQEHATQEAYENDLADYHIYEVMRKFASASRAMALYDCRLCLDELETLPAQHKRSASVMAMLGKAHYELGQYPEAERAFEAARNLEPHRLWDMEVYSTLLWHLQRNVRLSFLAQELLSTDPKSPQAWIAVGNCFSLQKEKTQALTCFRRAAQLDPTCAYAYTLSGHESIDEDLSKAISFFQSALRADARHYNAWYGLGTCYMRMSRLRLADYHFKKASQIHPQNAVLLGCVGVVRERCGEYDKALELFNRAIEFSPENALVRYHRAKILIAMKKYTAAVQDLETLRDTSPDESNVLFQLAKAYRLLGDDVKFTQLLAEVRDVAPKSVAKIRKLVDTVKDADVGEEVMDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFD2</accession>
    <name>A0A4Q9QFD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_912793</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFD2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFD2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020948174" description="Nucleoside diphosphate kinase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="13">
        <location>
            <begin position="32"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU66110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19864" checksum="7DFCFE676BB8BBB5" modified="2019-07-31" version="1">MYKTSAVLFILLHLFIFFHLPQPTPTVAMSVNERTYIMVKPDGVQRGLVGNIIGRFEQRGFKLIALKLVHATPEHLEKHYADLKGKPFFPGLIQYMASGPVVAMVWQGLDAVKTGRSMLGATNPLASAPGTIRGDFALAVGRNICHGSDSVENAEKEIALWFPEGIVQYTHDQAKWIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K1N4</accession>
    <name>A0A4V2K1N4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_918299</name>
        <name evidence="11" type="ORF">BD311DRAFT_684855</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K1N4"/>
    <dbReference type="STRING" id="114155.A0A4V2K1N4"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000053">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU62851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="543" mass="59506" checksum="14854304CD6B298C" modified="2019-07-31" version="1">MAEPQAMYATDEYGRPFIILREQGRKTRSHGVEAIKSHILAARTVANIIRTSLGPRGLDKILISPDGEITVTNDGATILSQMEVEHQIAKLLVQLSKSQDDEIGDGTTGVVVLAGALLEQSEELLDRGIHPIRIADGFDRACKVAVENLDRISDRVPFSQNDTSNLLKTAMTSLGSKIVSKEHQQFAEIAVQAVMAVADLERKDVPFDLIKVDGKVGGSLADTTLIKGVLIDKDMSHPQMPSTVRDARLAILTCPFEPPRPKTKHKLDITSVEEYKKLREYEKEKFEDMIKRVKDTGANLVICQWGFDDEANHLLMQNDLPAVRWVGGPEIELIAIATNGRIVPRFEDLTAEKLGRAGLIRELTFGTTRDKMLVIEECANARTVTVFVRGSNKMIVDEAKRALHDAICAVRNLVVDNRVVYGGGAADISCSLAVGKAADEIPSIEQYAMRAFASALDAIPLALAENSGLSPIETLAEVKSRQVKEGDPTLGIDCLGKNENDMRKQNVYDPLISKRQQYLLATQLVRAVLKIDDVIVAGEADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K362</accession>
    <name>A0A4V2K362_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_938480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the WD repeat coronin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145220">
        <property type="protein sequence ID" value="TBU53232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K362"/>
    <dbReference type="STRING" id="114155.A0A4V2K362"/>
    <dbReference type="OMA" id="NFQDDIY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000502">
        <property type="entry name" value="Coronin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="414"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="521" mass="56058" checksum="7087F81603021C18" modified="2019-07-31" version="1">MSRFVRASKYRHVFGQNGKKEYGFDNVKVTNSAWDTNVISASTRYVSLNWNSSGGGAFAILPLPSPFAPLPSAFPSKLPDLIPLARSHSGPVLDTDWSPFNDSIVASAGEDGKVMIWKVESGAFEGWGEDGWEPRDFDPVARLDVSPRRVGHVLFHPTANNVLATSTGDHVVKLWDLANPESAKSVLGGHGDAIQSITFNPWGTVLVTTCRDRKIRLFDPRAGGDPVRVGEGHSGIKGARVVWMGDKDRLATTGFSKMSDRQVALWETGGLGNVKTITIDQTSGVLMPFWTDNNILFLAGKGDGNIRYYEYESDNLFPLAEYKSSEPQRGMCFLPRRGLSVSDCEIARALKVAANSIEAIAFIVPRKSDSFQSDIYPPAPSAEPALTAAEFFSGKNAPPKLVSLEDGSISSVTGSAPIATPAPAPTRTTSAPPPAAAPATPAIVVRDEPSPAPSPVAAPPRIEPTRSQSLSQDNSEVSSLREENARLTSELREARAQIRNLELQVETVRANARKAAALLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K498</accession>
    <name>A0A4V2K498_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_819203</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K498"/>
    <dbReference type="STRING" id="114155.A0A4V2K498"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11320" checksum="770C3E2184DEF911" modified="2019-07-31" version="1">MIASALEWYGRSSFSPRLLGEWRAVFLYILLSLGTEFAVWRVPRLVGAVVAISVGFCLGPLFPITMNNAGRILAPKFISGSVSWMASSCSTSEGGVSIRHRGNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5C8</accession>
    <name>A0A4V2K5C8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_950090</name>
        <name evidence="7" type="ORF">BD311DRAFT_810219</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143487">
        <property type="protein sequence ID" value="TBU24095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5C8"/>
    <dbReference type="STRING" id="114155.A0A4V2K5C8"/>
    <dbReference type="OMA" id="ACFIICW"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU24095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7339" checksum="47381644CB76B08F" modified="2019-07-31" version="1">MADKVSPTSDVILYFLAIFIPPLSVFFKRGLKADFWINILLWILGWIPGVLHAWYIISRSEGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6I2</accession>
    <name>A0A4V2K6I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_952754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145253">
        <property type="protein sequence ID" value="TBU52393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6I2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="802" mass="89921" checksum="3E84C8627110EBFB" modified="2019-07-31" version="1">MLPTTAQRASVEKTACRKTFIVKFPSADAGAPILDATPSSPAYTLYANALSPESSLAEANIYYSFTSERDWKVGRWGKLRGPGSTALDELLAIEGVAERLALSFNTWRKLNKLVDTHLPPARPRFQRHEIVVAGEAFEVFFRDVLACIESLFSDPEFAPILLLVPERHYADADKTVRVYFDINTGKWWWSTQKQLEQEKPGATVVPVIISSDKTQLTTFRNKTAYPIYMTLGNLPKDVRCKPSRRGQILLAYLPTFRLLHIKNKAARRRTLANLFHTCMTRILAPLTSAGVNGMELVSGDGLIRRGHPILATYVGDYPEQVLVTGCKTGECPKCTIGRHEVGASHEPSQPLWDLGKVLDALAALDEGPRAFTSACREVKIKPISHPFWQDLPDLLAWIHEAYGTEEIDARCRRMPVNHSLRHFANGISHMSRVTGKEHQDISRILLGLVIGLPLPGGLSSARLVRATRALLDFLYLAQYPIHTTRTLDLLEEHLQAFHANKSIFVDLGIRTHFELPKLHSLDHYRCSIELFGTTDNYDTQYSERLHIDFTKDAYRATNKKDELTQMTKYIEWRLKQLNLISTGTASVPQDSVNVPPLPPVVDIPESSADYGASYFRDTLARYIVKTTNPALTVQQVEYESSPAPGTETRDVVHAPATRTTRRGTTLPGRFDTALIKVPIPVSNEPLARVRIVFKIPERGLQDLFPHIAHNKRPQHLAYVELFTDLDIKGIDHGLYKISPASNGQGQRLAVIIPVEDIERSCHLIPHFGPVAPHEGTSHNVLDKCTTLYLNSFADCNTYKLIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6J9</accession>
    <name>A0A4V2K6J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_910004</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145245">
        <property type="protein sequence ID" value="TBU52573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6J9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="41"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="435" mass="46348" checksum="B6F854B4124F73F6" modified="2019-07-31" version="1">MSLTGAAKPSSYGSIVKDDLSIIDDNEAVPDYDDFSDGGSAAWLTVFGAFLALFCSFGQMNAFGTFQSWYTTHQLHDLHPSTIAWIGSVQLWVFFFSGGFIGRVFDMYGPRMIMALGTAIYVSSMMLTSVARDYSHYLAAQGILSGLGVGMLFYPPLASISTHFRKYRATALGIAMAGSGIGGTVYPILLQYLFVNVGFAWGVRVSAIICFVMCTTATFTVTSGVTPQAPAKENMSWLDLRALKDPKFALLVVGSCFMSLGLFTPFCYLVSYASDHGVPSGTAFYVLAVLNAASVLGRVAPAHFADAFGRFTLLVPCAFLAGLSTVLLWPAADSLFALVAYAAFYGVFSGAFNALIVPCIAQISDIREIGMRIGLLYSIISFPSLVGNPAAGALLHVGHGSYTGLILLSGTSVMVGSGFMLLSKLKINSDIFARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7N4</accession>
    <name>A0A4V2K7N4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_930769</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7N4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="394"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="788"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="831" mass="94249" checksum="713261A7B9262F0A" modified="2019-07-31" version="1">MPNHQPNEQLSGSVDRNVNSNPPDPPPQSRSTPPPAPSQQPFLGDTENTPSKLSANATRNSVDKPQNKDLRPLYTGFEGMADNLSEIELEKMFEEFIPGEDPCADYLTHCDFDPHVADVEKESDLNPKICVMAHSAIAHARVCPTLVVRDISCWQVSGQDRKSSQKGTRSDCAVYLDNERTRKIVDMDRDDFMKSSRMSEEDKNARKDWVGRRAWGDMVAFVEAKHKHEGSAFEFNNPGTRFTRDDTDGGRKALGQFAEYVANILAHQHRTHVYALYVYRDQARICFFDRSGGIVSTPFHYGTTDDTTFQRFFYRLAGMSREQLGFDPTAVLADESVVDDLRAWAAAVPTEYLRKLACEALCWDPATNSSSSAEWPTHEVTFKGKTLYVGKPAFSNLSLFGRCTRGYVAIEKETGEDGSVTYSIRYLKDSWRNDHPNVHPEHEVYERLRSRGVVEYIPTCLGGEDVLGVAGAWQQTRTGELLPSKPLQRGHYRILLKEVCRPLSDFKDYRDLAMILGHALSAHQDSWEKADVLHRDVSYNNILIYETKNDNGDIIRKGLLADWDLSKYKEYMIPGFGPRQPDRTGTWYFRSAVSQRYPRKPYAVSDDIESFVHVYHYCVLRFHETAQSKTLMDTIRSTYEYVERRAEDGAYVGGFVKFEQMRIPHSVISPRNNETLRTLLELLAGICATHYATIDAEEFDRLYTPVPEGTGPAMSITRGDPADGDSDVVHVPEIFIGAQHRITPQPRPTLQDHSELLNFFREWGTIQWRDRDCVRSSEDLFKNVGLAPSKDNAFGSSQSESSQSRAVKRRKHNTGTPLTSVSENVERLDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7U7</accession>
    <name>A0A4V2K7U7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_929594</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7U7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020616404" description="Mid2 domain-containing protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="368"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU57378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="425" mass="44526" checksum="BF000686E00947C4" modified="2019-07-31" version="1">MPRLGLWLAYSFLSLPLWTRGVYGDNTTCASAQLDWYTDAVGETPCVTYQRLRQICNNDYQVQKFRPNTPGDNCNDQLSGCCCNSVAWALSMLCMNCQYDTEEGGDGIDAGVGGYGLYLGSCSPVQNKTLPNDIQSAVCNKEIKLDRSLYGLFWDTGAWFYVYTKETIVADLAASNNNTFTNCASTTKNDTTTTSGTQTTSGALTGSAAPTSTGSSSSSSHIGAIVGGVVGGIVGAIALGLVAFFLVRRRARSQGPRPLDLAGEYRYEDGGDPPMSTVTPFSATASQGPTSRSGPQSSASGSGAGSGLMLAGGSAATTSSKFAGVDGYPQSPPALDEEGERHADAGPVPQLQRSASGRLPPAYRSWEDEPNELEPEPQWDGPSVTGVPYAAAASSSDAAPLPQTPLSPQYPADVKRPAGHHDGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8I8</accession>
    <name>A0A4V2K8I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_976206</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8I8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="92" mass="9613" checksum="45DDAF08027E224A" modified="2019-07-31" version="1">MVLKLSDASANPGALLDAGGQNVSYNSSAPAPTNLSLFEKWAVGPVMYATLFVTEALGTSNTPRVVDLHANDGNEFTPAYAIDENDGLSRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M8C8</accession>
    <name>A0A4Q9M8C8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_917216</name>
        <name evidence="18" type="ORF">BD311DRAFT_733468</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
            <strain evidence="18">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="ML143556">
        <property type="protein sequence ID" value="TBU22132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M8C8"/>
    <dbReference type="STRING" id="114155.A0A4Q9M8C8"/>
    <dbReference type="OMA" id="GRPNMEV"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040683834" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="224"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="518"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="563"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="564"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="582"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU22132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU63321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="617" mass="66113" checksum="773ED5A2E51AB469" modified="2019-07-31" version="1">MRSLSALVALALAFGAAAVPSTAVHKVKENVVSPRGWTKRAPAPSDHIIELRIALPQPKFDVLEKHLYEVSDPFHERYGQHLTKEEVEALVAPEAESIHLVNEWLASHGIYEDDLARSPAKDWVHIKVPVSLAEEMLKTEYHIWTHDASGDSVIRTTSYSLPEHLHEHVELIQPTTVFSRTKSLKTSFRFSEAQEKSVAIAANAPPISVPSASGGHVDASCNQTITVTCILELYNAVGFKASATNGNQIGITGYLEQFANIQDLQTFFAEQRPDALNSTFKTILINGGENNQTLDEAGAEANLDTQFAYGLTFPTPATFYSTGGSPPFIPDVLTPDDSNEPYTEWLDFVLKQKTLPQTISTSYADDEQTVPVSFAKRVCAGFAQLGARGVSLTFSSGDGGVGDGEEDPALQECFTNDGRNVTRFVPLFPPSCPFVTAVGGTIHVPETAVFFSGGGFSDVFPRPAYQQLAVSKFLNKLAPGTYAGLFNPNGRAIPDVAAQADLFRIFLSGRPVSIGGTSAAAPTFASIVSLLNSARISKGLPSLGFLNPLIYALQATDPSVFNDITTGNNPGCGTPGFNATEGWDPVTGVGTPNFGKLKDIVTFDFADVLTNAAKLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MCJ9</accession>
    <name>A0A4Q9MCJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyruvate/Phosphoenolpyruvate kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_94067</name>
        <name evidence="5" type="ORF">BD311DRAFT_767225</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML143488">
        <property type="protein sequence ID" value="TBU24058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MCJ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MCJ9"/>
    <dbReference type="OrthoDB" id="1773at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308:SF0">
        <property type="entry name" value="HPCH_HPAI ALDOLASE_CITRATE LYASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32308">
        <property type="entry name" value="LYASE BETA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="116"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU24058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU62361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="428" mass="47407" checksum="90D21E2B21CF17AD" modified="2019-07-31" version="1">MECRLLLLLRWTGATRKQGCFASYHHYPRSPGLLETMFRATPRTLRLRIRASFNHVNRARLLAANLSSTAVRCQGSTGTVDDCDSLPTADDCRSAEEHEHALKAAARDGQPGHLGRSYLYVPCTAEKMLEKSLTTNSDVIVYDLEDSVPPSDPDKTSARSRIAHFLLTRHGSLPSPSRIAMRLNSNVTPFFEEDILQAMRLPCVRTLVLPKIHSAQDLHFVSEHIYMTYRAHKIRNPQGPPVQIVASIESAKAMHNLGEIASWQSAWGPEQGGKLSALLFAAEDYCADTGIVRTSTRQELLYTRSHIVVTAKAFGLSAIDMVCVNYKDPEYLRSECEDGKRLGFTGKQAIHPNQVDIVQSTFVPSDKEILRAARILKQMEKAHLANRGAAGLELEGGGMEMIDAPMIKQAERVVRIAKSAGLPIPEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MPJ1</accession>
    <name>A0A4Q9MPJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_982821</name>
        <name evidence="3" type="ORF">BD311DRAFT_807206</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143425">
        <property type="protein sequence ID" value="TBU28026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145365">
        <property type="protein sequence ID" value="TBU51194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MPJ1"/>
    <dbReference type="OrthoDB" id="2758082at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="41"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU28026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="618" mass="69078" checksum="E11DB71FF96C469B" modified="2019-07-31" version="1">MQYDLPPRKKFKVGEARSKPESSTPFPRTPLDGPIIQTAPIARLPTELLTTIFSLVGPYQRLIPFSDEGAKTWMGWARLMLVCRHWRNVGLSTRWLWRRIGVTSNLEALQYRLSRTVGCTIDVIFSSYSETNERAVPLLLPYARSIRSVQMPEWSLGFYESDNLPAIKPLFEVPLPALERIDLSGLPLLRGRPLDTPFDLGLSEKLHPGVRRLVMPSHIKMPSTPTFWSALRELDISSERYDGRQACLDDFLQVVAGAPYLESLAVLGTLTSRSLRRKDTPTSGDDVPTSPYRLARLRTVRLEGELAFVAPILQRIDAPALCVLHISACIPPDADIADSAALLFPPPLRHVLAKCKALYVSKNEPSDFQICSNAHQNPRNIQFKADALRVPLFFHVISYRPLPPQLSTVIGVLCDGFCTAPLQTLVFEEFSDSAPVAAWRSLQATFSDLQSIRVGSESLELVYNFFFALRGLAPEGGWPLLSCLEVDFGHISEQHDSLAWHRVLQPLVEATHAWHEQGLRLDDIILHSLHATGEKIGPIMLYDHFSLRNPVVFDTFSDHHMDDLVSSLLTGPKPRRWSGRYTGNTTGKEAKRGLAATDNTETSLSEVDSTQTENPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N5E5</accession>
    <name>A0A4Q9N5E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_911951</name>
        <name evidence="7" type="ORF">BD311DRAFT_647994</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N5E5"/>
    <dbReference type="STRING" id="114155.A0A4Q9N5E5"/>
    <dbReference type="OMA" id="CERAMNV"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU35884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU65731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10270" checksum="5B5438B0C9B39E4D" modified="2019-07-31" version="1">MYGFGDDRNPASDTVNVMEEILIEYIVDVVQTASGGGKKSRLSIEDLRRALSRPADAKKLARMEELLFMQEDIKRARAQFDEPDMHPAGSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N6G5</accession>
    <name>A0A4Q9N6G5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_763039</name>
        <name evidence="1" type="ORF">BD311DRAFT_597444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143694">
        <property type="protein sequence ID" value="TBU21163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N6G5"/>
    <dbReference type="STRING" id="114155.A0A4Q9N6G5"/>
    <dbReference type="OrthoDB" id="4207519at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13636" checksum="DDA9ECC0F087E7C8" modified="2019-07-31" version="1" fragment="single">AVSKAKQAHIDSELVKKYINIAANRYNEERESQRKPRGVRKICREVEQECFLETRKKITLPKSTVSARANGRTSIQDFNATKRWLTPAEEDVVVEFAIDAGLRGFPLTHRMLKDHVDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N6H9</accession>
    <name>A0A4Q9N6H9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_953411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145384">
        <property type="protein sequence ID" value="TBU51141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N6H9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="346" mass="39943" checksum="E37CE5A4CBC0B325" modified="2019-07-31" version="1">MAASELAAWANLFSEKWGARLIREWTQAWVRTRTLPESERGRHIKVVSLLSDSTVPMAVHTYLRSKKWSQNPVKLQKMLNNKLSSVKVHEYHHVLESEEMPNGLKKFIASKILPRYHLKPGRMGLFRSSMHRLLIKAHDGKQYSWLLHGESFLKKKGPGQGLHQSNFICSMNCDGFWNGEMFCKQLIEKFFPAFEVAHGPGHIAVIFVDNSQGHSCYAPDALHASKMNLNPGDVQPHMRDGWYDWNGQRITQTMSKGIKAALIEHGLWQHCDYTFDTLWENMPKALRSVSVELIRKWEHRAWRFIDTYTKGPGACEAQKKVKEFSSCMYKSHRRVPEQLAQAMDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9L3</accession>
    <name>A0A4Q9N9L3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_890079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145272">
        <property type="protein sequence ID" value="TBU52002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9L3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="327" mass="35731" checksum="7DE00202E017B50B" modified="2019-07-31" version="1">MAPTESLDAFGGFAGPASKQFYVATFSVEVCVFAAFLISYVIGTWCLFFCAQSKHPLRPLTVVLFVANTVMLWLAVAHMALDACGAVRGFTEGPPLFDAIKFVIYVLETLIGSSFMIYRLYRVYSRRWRVIIIPSVLLVAAGIIGISSTFLGVPGFYMSAGFYSLELMVDVISSIMILARVKEIGCDSQPTHARNIQMWRVIEALVQSTAITSAASMSLVITFVNSTYIGYPTCLNVLPPLIALVFSLTVLRIALNSGRKATRSESGHSWGISDHGSTMATAEMSSSTLEDAEEKEFTLPIYVSTTTIVQHDLPTHPGFSSNTIHIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNU3</accession>
    <name>A0A4Q9NNU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_842696</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNU3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="112"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="502" mass="56925" checksum="7BC5E11474C01859" modified="2019-07-31" version="1">MSQSPPADPEQPHIVSLVLHAKKALLQGQQLCTRASTISSASAQTAVDVLALDAQVRWMSEAVLDQLKLAAQVAKSIEQKRTELERQVKEWDIIRNQRTDALDAVLESLGTQSVPPDFHTVSSDSSPFGSQNNSDDERDEERHPEDDTTPFGPPSPPSSSPTDTIRNRSPVVRRHEKEKKSRREDRRKWKTLRDFVNERAIEDLLDTIEKDRLELDDILATTSDYPESLSKTIGAIKDMVPVEVPLPSFDAIFASQEGTSAKMAEQLESLAHHYDNMSNALHDFEAGEEFSEEDVQGMNGDADALPVIITELEEGVKAIDEWHQQLLTAKESAQEHLEVHRNTLRDLDELGDIMTEMLERQQTVETESIEHLSYLHAQLQPLEELHHKYTSYQYAYGKLVLELARRQRYREAAQRIIATMTAQLDAMAEEERILRQEFQAEHGQYIPEDFCLYVENLPNRWMISTWNGEPLEMLPLIDADIIEEAKQRTMGVDIGVGASQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQV4</accession>
    <name>A0A4Q9NQV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_829015</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQV4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NQV4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="293" mass="33078" checksum="F708DFF9E62097BC" modified="2019-07-31" version="1">MATLYHSSGAILLGGLVALFLSGAVLMQVVLYSRVYTSDPIKTKAMVIFIWVLDLTHSMMVCIANWQNLVVNFGMFDNLDHITWWVKRPCLLWLPTESHVYRSPQYLLWRCQLGHNRSHRTTGNLLISLIFRIRLRSFEQFVKRFGLQYVFTLGLSTSTSLDIVITGTLCLYLRRRRSGMAKMDRIISVLTLYTVENGMLTCVTTAISLVCWLKMSNNLIFLGLHLAIGKLYANSIMASLNARKSLSNRLESSGNSDGYPLPVVFPSSGYSPRSPTAPWEVSSGSPHQKPHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR26</accession>
    <name>A0A4Q9NR26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxisomal membrane protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_838284</name>
        <name evidence="1" type="ORF">BD311DRAFT_793279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR26"/>
    <dbReference type="STRING" id="114155.A0A4Q9NR26"/>
    <dbReference type="OMA" id="VMVFLFR"/>
    <dbReference type="OrthoDB" id="39659at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019531">
        <property type="entry name" value="Pmp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15460:SF3">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF013674">
        <property type="entry name" value="PXMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU35003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="23292" checksum="7AD3A19240411B6B" modified="2019-07-31" version="1">MSGLEAILSNPAYHDYLAILKGARNGFVYGVKVRFPHALIMAILFGRGDWQTRLKTIYRATRQHAFNLAKFVSLYKTLLLVQKKVNGGKERSFDTFIAGLIGGYIVFGERSAVNEQIVLYVCSRVVASFLARAKTPYSNAPAASGRPLPPDSRQFSIFAAVCWGAVMWLFKERGETIQPGMFNSMTYLYRDSEHWDSLKTLLWHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NT84</accession>
    <name>A0A4Q9NT84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Plastocyanin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_959991</name>
        <name evidence="1" type="ORF">BD311DRAFT_791031</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143480">
        <property type="protein sequence ID" value="TBU24424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NT84"/>
    <dbReference type="STRING" id="114155.A0A4Q9NT84"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU24424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="10977" checksum="46BB3E012F23507C" modified="2019-07-31" version="1">MSRLHSFSRPIPATDSKLVNRVVSLDGVTHDAALAGRSFPGPLLRGDIGDHFQINGMDELCNESMATALSIHSHGLLLHTANRAVGAAFVTYGIWELVLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUN3</accession>
    <name>A0A4Q9NUN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_574473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUN3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="40495" checksum="BB12416EDFFC3342" modified="2019-07-31" version="1">MPLLAMAPTRKPFTNAQNTVTTATPSRRPRSSNDPSKKKRQAKDAAARTAKKPLKPSSTSPNVPRAREYGVPRHLKNVKSVPQHAPFEPRIAAADIEVVCQAAEANARAANMGHLDEMQFGREAAALLGPGLDRVPGRVVFGDDALRKYSKSAGLNEHVQTDERDVVRYEHPDAWECRQRAKGRPPPLPHTDLELPVVCVNNENAFGIDAMLTGGHGFAWMVTPECAELDRLGPFHLFNNPGPMDSWYIRNWHYCGRYYAHRTGRQMNLDGWQKLPQAIKDAATGINAGAPSGLCVELIILQFCGLPDWTVWGKLHEAAANCVRPAKPPGTPPNRLALPRLFAKHGQELIDEHAHMQSIRLTGRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVY6</accession>
    <name>A0A4Q9NVY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Stretch-activated Ca2+-permeable channel component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_935104</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVY6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NVY6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024338">
        <property type="entry name" value="MID1/Yam8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142:SF1">
        <property type="entry name" value="AEL197CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39142">
        <property type="entry name" value="MID1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12929">
        <property type="entry name" value="Mid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="488" mass="51639" checksum="B18290264D2B20B4" modified="2019-07-31" version="1">MTWLPVSLLAVIQSFLLLAEAQQKLSLDTAADLNTNNLPSPPTLSVPSNGNPLTVSVALCATSSDPPRFFVTNDTTIPQPSVSDVDNVNTYEIVVGPEGFGSKQLVFINGGIVSVVKGSTATPFEVFISTNNATSEISNPLLGDTTSNQALIFSPAFDPPTFQQPGFPNYTLPAANLSIPPEPSSPTNYTLVFAPTSSAPFQGLPRTSCAIKSRSTAKGVITLSSVQSDGLWLRDMNGWRWEWFLGGLTAKTNYTAYTLQQGQLAASKPINFVTKSPTFNCPLLHQLPFCPSISYAVPLTPPRPPSSAHTASTIPSNVSDTIISYLSNLTTTLTTLACGRDHYSPLVTCADCQAAYRTWLCTVSFPRCTESPENSITSGITTVSGSSTQGPQVPLPAIKSVQANATPRNPTLPPFNSDYETLLPCLETCNAADRACPAFLGFKCPLPKFTASNSYGVGFVDSTEDGVMGGGTTGVAQDVYGNVFCNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWN4</accession>
    <name>A0A4Q9NWN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWN4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NWN4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="391" mass="42921" checksum="B6F4DEC53C8429D0" modified="2019-07-31" version="1">MATPGVQDATAPPSDDDVQAFCDMLDQMRVSMSSARDIVKSLKEKQGTTSELDTREGISLLSLKHHMMLSYLQSLSLITARRAIGHSLAERSAPQAPFSAKDRPARGDGAGDRVDAAIEARVVLEKVKVLEGRMKYQIDKLVRIAEEGASSDKNIVNDPLAFRPNPQALMDAAGSEPDDEDEGAPATSRDGIYRPPKLAPMPYIEPRKSKDKAKDRRAPVPSALAHLVHLDPSKPYVESTSGLGSTPALSSARARELKRMTEFEEENFTRLVMKKKDARRRDLDLADIALGGTGMASGNRRRVPGVGLEDEFGDILKSVGRSRQGVVGDGYEELRQRGKKEGVLARSRARSRDDSFEDLGDDGPKQRKRTRFDKEVKAAKKRASSKSSRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3S2</accession>
    <name>A0A4Q9P3S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_807477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3S2"/>
    <dbReference type="OMA" id="DQVDMSK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14002" checksum="4F000DE4C2561109" modified="2019-07-31" version="1">MRSALTLLAFAASALAYTVTEPDASTGWTTSGPNVVAWQSVSTDPANFTIVLDNQVQQPPTTQVLDALVVGSEGKITVNPPSGGWKAGKGFRVNLVADTEHLTTILAQSPQFDIVASTSSTFSTAVTATSGSSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4N8</accession>
    <name>A0A4Q9P4N8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_807303</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9P4N8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05579">
        <property type="entry name" value="STKc_MAST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000580">
        <property type="entry name" value="AGC protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="83"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="137"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="409"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="867"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1254"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1364"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1527"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1595"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="689"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="262"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="908"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="934"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1061"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1527"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1642"/>
            <end position="1651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1652"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1678"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1700"/>
            <end position="1723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU64012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1894" mass="208587" checksum="BF1775C375B86242" modified="2019-07-31" version="1">MSDSSVPRRQPPSPLVFSPETVLNNPIQVQPSTSSAANSHGSGSNMVSMPFVRRHVTRRLKAAKAECDKELQRVTNSITSFFEERLREGEHEQEQEREQREYERERDRESQAGDIEPLREAFVLQPQELRSALQFDEVSSDGGYEAEPEGHGHSRQRAFLDDDRLEHPTLTHRASSPGLLTASVSSTSPSSLRRHPTLPRERPINVVASNTGASSPSSVTTPPPEAVSPRKQGESSRSGQWAGQSLASRRLSRTIHIPARPPRSGHSSRSTSRSRSPLPRSSYADSSSNRRSSRILVDDPIDPIMTTLYEIIAVATDVLDMSINQLTANPKVCETLVQRVQNIGKAWDEHPDWHGRNWYVQVLLAIASLSRVVEWWEAEKQFWNFDDNDDEQEEPLTFVMKPAEEEIPANAPTLAARPDQENTLKLSAEDENRLRMSRTTSANRRSRDEATKDISSSAATPQKDSDHAKGTASKFDGTNESARVLATERLRLQAETAQNQNIVMELSLDGDHFIWINYAWRGVVGTDPEDYFGTRVSKLLAPSDWHVFRDATRRLQENDSRTVEVKFKLRIAGSDEPSNLYQPMEGSGLLMVDLKDGQPTHTMWVVRPVGSPEVLQAPPSILLETGDVGDDPASAEATQVGFGERSALEPVTPFPFARPINTAPILCRICECNVPQWYFEKHNETCSEVHRLEAEIAECNESIAELRNTIRDLQTAMDRSSPMTVPEYRGMPIFSPSTSPSSSSPLQLLRAPLKMKRMSVKRMQRQVLEQLEDVLQTCVEVSIPALKEDESAEPIERQRLLSPTSERKMAQVRHWNKPSIEDAALTQLIEDAERVMRQKIDNVVRMQNTIRYSEKIRQEWEEKVERTLQSWEGEDAEDAECSGEEDERDERGEDRPEGEGEQEDDHSSTTSEYAFTGQQSSADPTPIASASPIPFNPAPEPPPAVSTMSPSSLPSVSAVPVPMYWHLPQAITAATNTTHQTRCSTPSSISSPLALAAPIVAHEQPPMLDLNEPVSHVTIRARRSPQNLEPKLLITPPLSPMVSPQDASNAGTRRSHRRHSTAQPLISPTASMSGQPLSPRLPSVAPLSRTTPTSIKDFEIIKPISKGAFGSVFLAKKKVTGDYFAIKVLKKADMIAKNQITNVKAERMILMKQAESPFVAKLYFTFQSKENLYLVMEYLNGGDCAALIKSLGSLPEEWTRNYIAEVVLGLDYLHQRGIVHRDLKPDNLLIDQHGHLKLTDFGLSRIGLLGRQTRAPLVPEQRGARGHNRGSPNSRPPSIDSAYMAPSPMFPADLMPGGGSYFSHRTPSLPRPGSSPYLPLTDDPSESSGSESLASGFLSFRRSGNTRQQLSDSPLQSFASELTNDLRSHPTPGGTPPGEQKVVGTPDYLAPETILGLRGDDAAVDWWALGVITYEFLYGIPPFHDETPEKVFENILSGHIEWHEDYVEVSPEAKDFMQRLMTLDPTKRLGANGADEVKAHPFFAGIDWDKVTTTEAAFIPQVTDPESTDYFDPRGAVLQLFHDSEQPSLTQQFTSDSTGAPAGASPEAPPASAPVTLTREATASPSDDDFGSFSFKNLPVLKKENDDMIRKLKTETSQQQLAPLTHALSEPPNIHSRRRSISSRVGLKKPTSIVTPVDTSKPPLPTNPPSPATSTSSISSSVSRGPPTPGSASSHARKPSEFGAVERFKLNHLEGDVSRRNSMPSRLRTASVSTTGDGSVSDSWSNAVPVTPVQFETPPSSVASIDLKRAPDPSDRAVTCLLAEDNPITAKIIETLLIRLGCRCIVVADGSEAISVAMGDIKFDCILMDLHMPILDGEGAARYIKSTNNKNSTTPIIAVSAYSGAEVAECKELFSAYLAKPVQKADLVAAMRQLGFKTSTVQGRGQSTRLTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5K8</accession>
    <name>A0A4Q9P5K8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferroxidase</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_913522</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>4 Fe(2+) + O2 + 4 H(+) = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the frataxin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5K8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P5K8"/>
    <dbReference type="OMA" id="APDRYHE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00503">
        <property type="entry name" value="Frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017789">
        <property type="entry name" value="Frataxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03421">
        <property type="entry name" value="FeS_CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03422">
        <property type="entry name" value="mito_frataxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0409">Iron storage</keyword>
    <keyword evidence="6" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="20596" checksum="70670BF46CEB53A5" modified="2019-07-31" version="1">MNLRQVFKVSARPVSALRCASRLSASRPLHVLSQLSRTRIPPPSCPRRHYATPPPQVKHSDLPVNLYHQYSDATMEKMLESLENLLDEAGDPEYEVDYGSGVLTLKLGSHGTYVINKQPPNKQIWLSSPFSGPKRYDYVPERDDWVYARDGRSLSELLNQELSDVFEREVDLGLAEVSTQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5R3</accession>
    <name>A0A4Q9P5R3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_926403</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5R3"/>
    <dbReference type="STRING" id="114155.A0A4Q9P5R3"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU58722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="290" mass="32797" checksum="DB11305671ACB174" modified="2019-07-31" version="1">MRYAVLVTGPAGAGKSTFCNGLMTHLQTSKRSGHLVNMDPAANSDAFEYEPSIDIRDLVSLEDVMDELGYGPNGGLVYCFEYLLENMDWLDEELGGYEDDYLIFDCPGQIELYTHHPFLPTLVRHLQRLGIRTCAVYLIESQFMEDKYKFFSGVLSAMSAMVNLEVPWLNIMSKMDLVTTNVEDKGSGRNGIRTRKDIARYLEADPMLLLSAPGSREERTERNSKFHALNQAIVQLIEDHPLVKFLAMDLTNPDSIETVLSHIDYVMQYGEDEEPKEPGDLDEGDFAEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9E6</accession>
    <name>A0A4Q9P9E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1038744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9E6"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9E6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043780937" evidence="2">
        <location>
            <begin position="29"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20300" checksum="563495251FD16B61" modified="2019-07-31" version="1">MKTPTLRFLFHVAAICLLVCPASNGVLAADINAERMALERRYTTPHSLGDNYLFDPRDGWQSVNTTNLLYKYQSRAPVPDSARDDLDDADHLDPTGGTGDTGDNDDELGPRAAEHHHSYTHGTADMRLLPRAGAEHRRHTYTHGTADMQLLPRTDADEHHHTYTHGTGGMLLLPRAKKAHSKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9F5</accession>
    <name>A0A4Q9P9F5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Copia protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_793766</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145437">
        <property type="protein sequence ID" value="TBU51028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9F5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003964">
        <property type="term" value="F:RNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039537">
        <property type="entry name" value="Retrotran_Ty1/copia-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648">
        <property type="entry name" value="TRANSPOSASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42648:SF11">
        <property type="entry name" value="TRANSPOSON TY4-P GAG-POL POLYPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0229">DNA integration</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="9" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU51028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8574" checksum="99A7C4C8AEC7203A" modified="2019-07-31" version="1" fragment="single">DARLPKRYWADAMACAAHIISRSPAKGLKGNTPYEVLFGRPVDPTFFRPFGCTAYALIPKDKRAGKFGPKSTKCLMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBW8</accession>
    <name>A0A4Q9PBW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_952818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26745" checksum="4A316A85741ADD72" modified="2019-07-31" version="1">MDDDRAHPKHNASRFPVEVCENIIDMLYSFFVVDRVEDSRTLHNCALVCRAWRVRSQRNLFYSVVLHDLPALQKFSAVLDNRPHLCDYVHEVTILGGTLYTTASPLSLLPIALREKLPRLQKLTVVRKGDDWYAETAKPGTLFLSAFTTVPHLNIFNVTFRYFSDLARMINSLPALRILICGGVRCMSLGPMPLNMKPRADGIHTPAPPFAPNLPELRLSLDKIKAMLNSPMHPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCW0</accession>
    <name>A0A4Q9PCW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCW0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="41"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="168" mass="18818" checksum="1AF88CBE8997E4BB" modified="2019-07-31" version="1">MPRSTDQPVAGSEFPPLSLCEDLGREAGKGNIQFRLWFDGGGVVLIAEHTAFRVHASFLSRHSPVFKELFTVPPAPNGERIGGCRVFHTSDSAEDLNYLLQLTYDAPCLLRPINPSGDTAKPSFAMISALMRLGHKYEFFTLVDDAARYLETYYTTNFDVWEQLRDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDR6</accession>
    <name>A0A4Q9PDR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ricin B-like lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_382468</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145366">
        <property type="protein sequence ID" value="TBU51192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDR6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
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        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020182645" evidence="1">
        <location>
            <begin position="30"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="49"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16056" checksum="78DA18CC12D7DD19" modified="2019-07-31" version="1">MATVASGVYFIKAFAALTVLTLFNGSSHSGTIVQGDAKRDLTDPSVILQLWVVAQVNGTSLYTIENAQGGTFLDLLGSSNASATPVVGNSQSGTSVQQWSFMPTSANTTYTIVNSATNTVIDLYAGGTADGTAVNGWEYLGPTNTNQVWDLVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDV9</accession>
    <name>A0A4Q9PDV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCR4-Not complex component Not1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_962268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDV9"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="155"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="201" mass="22440" checksum="A29F5241B02E8686" modified="2019-07-31" version="1">MQRRFHSLPSSSIQVLPGIRSCFSMRSDGAPNMQPITPACLDAVDTGESSTPLDASQIPPTTAQPTTTKKPRAPRKTPQWPPPADLRGAKWAYARNWYADTNGSQAEFKQHYKSMTPSDRRQSDPYDLLYAALPPHQSQSMTLRLVVASHRHSSVLKLVLLLQPTYLPGFVFSWMSLISHRLFMLKLLPSKNREVGSGPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE49</accession>
    <name>A0A4Q9PE49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1005179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145312">
        <property type="protein sequence ID" value="TBU51517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE49"/>
    <dbReference type="STRING" id="114155.A0A4Q9PE49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="866" mass="94749" checksum="73AD9B6C8FF3FA36" modified="2019-07-31" version="1">MGEICLSVAPNLRCQSLTRTEAGILLVPPGLEIIFAVVLLWAKRGADKKHVFIAAEVFIYFLLAVLDVFTHTLPTIGTSLDSFRSLDIIIGAASFIPLFLYMFSIYLLTTAELIPSLPIRFQSITKYVLLAFIPLVIVLNELGSFIGITYRQFPGTNGGPIQLGVGFTDPTPEMFLSSVTLVLFVAFQASNFCIAFYRLIRALSHQRTLDSSQQEKEMETHLFRGLGWIVAGLKLGAVETVIGFAQGGFGVVFTRRLLRLLAHGCLIIGIIKGVDTVEDFQLYSPGQAQKRRKSMLRAMIQNPRFSTFRHVGGHDFSEKNPFDEKRQSVIKLGDPSWMRRDFGRPAAIEEERATPGLLSRTHKTSSLTFQLAARPTLSRRSDSVRDSAVSFGSSARSSYSDGKNPIDEYADVQEDTRQVDVSTFPAPVPRVGLPARPVRQRVTVHIRQDRLPVLELRRFSNLEFLDLIQDPFRDPHVRARSLPNDFEPAPDHPAGRTSASFTRLPPYVGAPAPAAPPAVARDASIRGSLASRHSRASSLDSYNRLWRGASVNSESNMPSFDPRLSYASTDYNPRMSTASWSYSDAQPGTGMSFTAIGSPTDSISSFVSPNSLAPPVPFAMLKSDRRDKGLSSSTTASEVHALTMQFPGIPSRHFSQPARRSMLSQEVSRDDFVVDADEPMPMPPAAADAQSSAPSPVVVSQTPSPRRKSPPAPLITSGLKDSRISNVEIEQVVDEETAVASLPTPMSPPQYVPSRTLAHGRLHSTPHVADVPVTATSVDEEDSDDAGLQEVPIVRSASLVRRGTDRGKLVRMKSVGHAPVRSVSASAREQSMARDSIKVELGLIARGGREQMAEVMMYDPAADTQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEI8</accession>
    <name>A0A4Q9PEI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CHY zinc finger-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145224">
        <property type="protein sequence ID" value="TBU53138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEI8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEI8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052604">
        <property type="entry name" value="Mito_Tim_assembly_helper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082:SF2">
        <property type="entry name" value="CHY-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28082">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13864" checksum="3FF08ABBCC71BB50" modified="2019-07-31" version="1">MCKHVLNAQVAIRAPCCKQWFDCAECHAETQTHPLAKTTEMVFLCKKCKKAFRKDMSEYEESDEYCPHCDNHYVIEAKTPQAVLGVEGEDPRIDARMLKDDRTKADRARSLLNLDTSDRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEL7</accession>
    <name>A0A4Q9PEL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_860397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEL7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="25"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="36756" checksum="9DEE4BA92EB3C44D" modified="2019-07-31" version="1">MSSPSDMTLDSIFSTYFWMSVIFHLSLAMSVVVVYDWVLSLPRELRLFWAGNARSLSAWLYFANRYIALFSEAGQLLVFVPWSAKGCTRILLATGIPTAISMLAQAAFHGLRTFALSQSWCLSIAVFALTCMPFAAALMDFGYHFTGAQVVDPIFHGCIPRLDYPLSLAHTFTILNRVCAIVADASLIILTWRSLHQHVSHVMTEKGLMGVFLRNGMIYFVALLILNILLLIVFQQPTLHARVTGDPASPTLSPISSILVSHFMLDLQEAYQRSSDIQVWDDSLCTSQHVISSGLIFVPALGSIAAHIDAPHLDTPVAETDSSAYVLGGTTRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFT2</accession>
    <name>A0A4Q9PFT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_941401</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145280">
        <property type="protein sequence ID" value="TBU51872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFT2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="188"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="36373" checksum="980E60B78BF2AEC0" modified="2019-07-31" version="1">MPSLSLPDMLTANSDATTPLAQLLHLPTLDETYGALLLGSFVGLLLYGVVVHQAYRYIQMYKDDHLVNKLTVLSLIVIDTAHCIACIHSCYVYLVSSYSDPLALLYGIWSIQCQPLLAGLAVLVSQSFFARRVYIISEKYRFLVVISLLLTFVTFGFSIAGTVVAFKLHIFTQYEHYYWMDSAACAAAVAADALTTSVLTITLRQSRTGYRHTDTLIDRLVLYTINTGLLTGIANCSALVFAIARPDTFIWIGIEIVAMRLYSNSVLALLNSRRSLRAPAGSNNLELSTRALYGSDDLPGGSGSQKSANLRTLERATTVLRLPEATTSSGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG16</accession>
    <name>A0A4Q9PG16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_859555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG16"/>
    <dbReference type="STRING" id="114155.A0A4Q9PG16"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="140"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="405" mass="44898" checksum="CE53DE70F9C58A14" modified="2019-07-31" version="1">MGVIDTQPGKTLYVIYWAGSLILVKLPFWSLKYALPSQRPRPTWTWKRAMIVKLIQEIFSCKVDLWEDEERDLTATILDSSLTDAKFVWVEGVDDELYCGEIRRLGQITGVLPAKIGGYWYLKKDSEWDSPKAKPGEKTVLFMHGGAFYRGTAHPSDITANFPRGLLQRSQTLQRIFAIEYRLSASAPKPPANPFPAALLDTLAGYRYLVQDAGFAPENIIVAGDSAGGSLAVALTRHLIENPIPSLPPPGRILSASGWFDLAMSRVGPDSSNVLNGPIDIFGAEEPGTIFGEYQVTAYRGALDFEVVKTNRYISPSSLECEPTKGRGLFEGFPETYVAVGGAERGLDESTALIERMRADGVKVVEDVPPDAVHDFVVFTWHDPERVEVLGRMGRWIDAIQTREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGB7</accession>
    <name>A0A4Q9PGB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Proline-specific peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_971243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145316">
        <property type="protein sequence ID" value="TBU51486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020567523" evidence="3">
        <location>
            <begin position="19"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="72"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU51486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="37313" checksum="659ABA1D917E6B54" modified="2019-07-31" version="1">MQLCFPALLGSSFILATAAQILPVPMSINDLTSMPASSVPIKDGHIPFPYKGETHQTYYKVFGDLEHRTRTPVVVLHGGPGLSHDYMLPIADLADESYGYPVILYDQIGNARSTHLPDQPEDFWNVDLFLDELENLLRHFQIQDGYHIVGHSWGGMMASEFVVRRRPSGLQRLVIADSPTAVELWGKSFAELLQKFPQWVKDAIAKGFEDREAYWKALGEVYAVHGCRVQPMPKDLEYSLLQVYGEGADLTVENAPILKGWTIEDRLDQIRTLTLVINGKYDIAQDYVTRAYVEKIPGARWIRFEESSHTPHFEERDRYMKEVAAFLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHD7</accession>
    <name>A0A4Q9PHD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_981517</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145232">
        <property type="protein sequence ID" value="TBU52911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHD7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU52911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="523" mass="58237" checksum="76F26E45910529E8" modified="2019-07-31" version="1">MVGSLEKAPSPAYDAGSLHDKERDPEKVLETPTSESDSEANVGLHEFDVAKQTGLRVTPEESRRVARKIDIWILPMLCVCQGLSILDKSALNYGNLYGMKRALHLTGDQYSWFASVFYIGYLVGNYPDGWLLQHYPSGKVLAITTFIWGTIVLTTAACTNFAGTMANRFFLGLLEAIVTPGMTILTAIWYTQNEVPFRSLIWYSFNGWSGIFGGFVAYGIGHISHPAIDLWKYVFLILGAISVSYSFVLWFLFPDSPVEARFLTEEEKIIAVKRVAEGKMGVKNKKFKWYQVQEALIDPKTWLLFVASIAAQIPNGVISNFSTIIIKGMGFTTLQSTLLDAASSGVQIFGLLSAGFICMRFKNMRVITMAAGNITCIIAAACLTYLPSHQQWNRLVAFWFTQFQSVGFSLSLVMISNNVGGFTKRTFVTAVTFVGYCVGNVIGPHFILDSEAPRYTAGTKAMFIGYVIKTVAHLALGLYMLWSNIRRDREQGKVTSPGDQLKGEEAGMHDLTEWENKFHRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHP4</accession>
    <name>A0A4Q9PHP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_830509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145221">
        <property type="protein sequence ID" value="TBU53201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHP4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="165" mass="18433" checksum="6EFBB1B4F81F4395" modified="2019-07-31" version="1">MYFSTYHLDVLIVLAVNSTLGILNSAVQAPSVKRVSYFSATAVYVTTSVKPNVWDDSGWNWNKTLAGQSTWTFHREQKEKSSIECDFVSLCPPWVLEPALHEFDGKANHLDHWNSFLYNAIIKGDFCPSDESYVDGQDLTKAILLAITKPAAAGQRFILAAGQFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHS4</accession>
    <name>A0A4Q9PHS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_162708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145218">
        <property type="protein sequence ID" value="TBU53291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHS4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11045" checksum="A01E035CB08EB509" modified="2019-07-31" version="1">MGRSTDLYLKHLTTGLAEAHADVVDAGAGASSCGDEPAKLVCGCARCGRCVIIALPCRSVQLAHWMRSRIAADDSGVRSVWPQWTVLCHLTCASLTQDAYGVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIN9</accession>
    <name>A0A4Q9PIN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_111394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145201">
        <property type="protein sequence ID" value="TBU53930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIN9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11377" checksum="482D1BBFD3BDEBCD" modified="2019-07-31" version="1">MDSMRNSVLITLTASCFVVVFNKGRNMQTRLLARFKYYGSAGSKHPVLTSKSMWACISWSCCRIRHLSSGTHGTSPSSITGERCYAVRRGGPSRACMHSRPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIU5</accession>
    <name>A0A4Q9PIU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_980718</name>
        <name evidence="3" type="ORF">BD311DRAFT_805144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143403">
        <property type="protein sequence ID" value="TBU30836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIU5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIU5"/>
    <dbReference type="OMA" id="HIHWSIA"/>
    <dbReference type="OrthoDB" id="3206554at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="184"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU30836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="359" mass="40174" checksum="C022DDA83B23FC56" modified="2019-07-31" version="1">MALPVLDLVAATLNSSNGSATTIFDHPPPPVLLGGFVALYLSGAVFMQVVVYFQIYQAEAWTTKSIVLVLWVLDILHSAMICIANWQNLVVDYGAYNTLDNITWSIPVTIALTALTTAIIHCFFIRRIFKLSRGNWFITLPLLLLALLRVVSAFVTTAEMLRLRSYVLFIQDFAYIFTLGLAVSAALDILITSILCYYLRRGREGFAPINHMIDLLILYTVENGMITCIATALSLFFWLFMRSNFAFLGMHFVINKLYANSIMASLNARKSIVGKVSGSERGYQLPMILPHHPQSPRSTDHFSRGQIQSTSKPLQVTIDVERTVQRDGTIDADSKSTSGVDLRLSHKPINDNFSDIRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIW8</accession>
    <name>A0A4Q9PIW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_936957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU54005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CofD-like domains"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="484" mass="52585" checksum="26948AA6D4FFAF27" modified="2019-07-31" version="1">MSYFALSPNPRNSGADSPGSSVFDLPTQPGPAHATPDRSSSVATGKSTGLLTSLSGETSFVVISGGTGCNSICPAFGRSACYILPVSDDGGSSSEIIRVLGGPSIGDIRSRLVRLIPPARPGAPLDAIRNLLAYRLPAKCTEQEARDEWRDIVEGRSRLWTGIPNDRKEMIRAFLVRFEHEILSRAHKNFSFVNGSIGNYFLSAAQLFFHSLPSAIFLFSSITSSEANILPVIVTNHTVTIAAELDNGERLVGQCEISHPVRQAPRISVYGEDDAAVDPLDGTLPRSRNVLFEAEGKNDYEPLNARISRLFYINAYGNEIHPSPNPDYLYSMSRYNVLVYSCGSLWTSIIPCLALKGVANAIAGSRSLKAKVLLLNSTNDRETDGYSAVDYIRIVARTLNDGHHAKTYGGLSKADTTWPISAFITHLVYLKGTAVEVDIPQITYLGVRCIEVEGPIDERSQLPQFDASSVTLAIREILDSFADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ39</accession>
    <name>A0A4Q9PJ39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_936697</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ39"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="394" mass="43156" checksum="281C4A93C740BE6A" modified="2019-07-31" version="1">MSDSLESLVPLVASVYPSNEIGLSVVTITIWDWLLCINDEVYLIWPSLRTLKASSIIYMLSRYMMIISEVTTIPSAGPLSLRVICEALSWTGNVAIFLARLTFAVFSAVRVYALSGKGILLSLIVFLLASVQAALNMLFVARYVEFEMFPAPIYCAGIGIPSERLAKIMTITIRATLLAAEVIVIVVTWWYTYGIHHGLKGLGSDSSLASVMLHNADAISASVMGVLNILHIICYVLDTPSLATLEQIVGTLIDPLSSILVSRFVLSLRHVDRPIAPLTATEQASITLQFARDVHRTTLPSFVASLGELVHVGSRSAKETFDSETGSDIELSVTGTNPLKIEEVPVLMSMTVGRQSQERTPVSIVTLREVRSVLKETRYVGPNRCRRCHAVHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK98</accession>
    <name>A0A4Q9PK98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_987563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK98"/>
    <dbReference type="OMA" id="WRKGGYQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="43491" checksum="6FBF61DB98334D61" modified="2019-07-31" version="1">MAIVPSTLSTFYKGVPPSFQWPVKFCIYNTVVAFVLGAATGNVSQVDRVWTFLPTMYAAYYALLPLWPSKSPLPLYPFLPETAHPDIAHNFSPRALLMFGLIFIWMCRYVTKLVAQSALYRLDISLSYNTWRRGLFNLKDEDYRWAILRSKMSPLLFQVFNLVFIAFMQNVILFVLAVPVQIAAMQQPAKLHVSDYFLAGLALLDVAAEFVADNQQYSFQTFKHSGVRQPKTADWPGARIEWTTADANRGFITRGLWAWSRHPNFFCEQTFWVIINLIPLVAPEYPGYEPPLPLGSGTPLESLFPIIPSLVISSLFFSSTIFTESVSAAKYPEYKAYQQRVSMFVPFLTPVWGLYLKLLGKKEEIDKLVYGQDLPKGKKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKC3</accession>
    <name>A0A4Q9PKC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_827664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKC3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="137" mass="15568" checksum="9429E77ECF871AA2" modified="2019-07-31" version="1" fragment="single">GDAIVCWRACVLWRGNRAIKTLCVSFLMTTFGKYIYRSFQQIPLILSCHIRVGYGGHRFSYGVAATVLTFGTNLLATVLVGYKAWKAKSDLRKYIVVGPIASQIEKIFALLLESGAAYCTLWVSPFHYEQWDVRRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKP4</accession>
    <name>A0A4Q9PKP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_729447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9937" checksum="E4E11B409F740950" modified="2019-07-31" version="1">MKFWLTCAIVEMASKPATPHFAGAHTSTASNPKPLQQAHREAPDIRDCVCTGSETRKPLCGAVGCPQSSVRKRANRVNGRIPRQQQLQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL83</accession>
    <name>A0A4Q9PL83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptide-methionine (S)-S-oxide reductase</fullName>
            <ecNumber evidence="2">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Peptide-methionine (S)-S-oxide reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_979969</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(S)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[thioredoxin]-disulfide + L-methionine + H2O = L-methionine (S)-S-oxide + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="2"/>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL83"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1060.10:FF:000006">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="entry name" value="Peptide methionine sulphoxide reductase MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43774:SF1">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptide methionine sulphoxide reductase MsrA" evidence="7">
        <location>
            <begin position="10"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU54937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="20452" checksum="9ACFE1F93EA0FA48" modified="2019-07-31" version="1">MSGSDSPEVATFASGCFWGVEHIFLKHFPPKENKGILKTTVGYTGGKEDATNPDYKTVCTGTTNHAEAVRIEFDPSIVKYEELVEFFYRTHDPTTVNRQGKDTGTQYRSAIFYNTPEQEEIAKRVTKEVQKEHFDPVGKKIVTQIVPAGQWWDAEDYHQLYLFKNPSGYQCENHRLHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP83</accession>
    <name>A0A4Q9PP83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_950353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="800" mass="89877" checksum="275334EDA02F09BC" modified="2019-07-31" version="1">MAKSAAELSLDQICQAFLPCRELASRMKPLTLVSLGALQKADSLPEVKLSKLFIDTVNTTHILSCATVSRFPSPEENRKEAVRTDAAIFRHNSTSVVTTPSWTDQIVPVASSPYFAGGDPFDHAVYDDPYGAIEAERKRVFDRISTIVDVLFAAQQRVFVFVLLVIGRSFRLIRWDRAGAIVTSSVDYYTNPTALLDYLQHISALDDSTLVFDPSASGILPGDVDFLRMDIAALEHSTDEDHSERDLDREVSGDRMVFRYARTLFRSSLATDWPRHKLRVPCGSSWRYYLVGKPTFRADGVMGRGTRGYVALDCETRRFVWLKDAWRAAYMISCREGDVLEKLNEAGVENVPTLVCHGDIDDQVTVTADWWAREQPSSAAPSTSSSQGSPTSSATLVESASSGSRKRKRGPAGEPGDERTRNLATCSDHPLREHQHYRIVVAEVAFLLRSAQNGRQLTSIVLDTAATNPKTLLLHRDISAGNILIYPRVRQGKDDTKNAIVWTGMLCDWELAKPVDDQRAPSNAPRTSQMGTYQFMSVNLLTDPSSPSVTIADELESFFHVLLYYSLRYLRSNCESPDSYIANYFNSYAGPGRLLTCGWKSLAVELDAFLSLQFPYSPLLFDSPMDDLLEMILKSLRARYKVIRDDLRKAMPPPRDPTPPPDKRMMFSVPKIFFFGDDANAVDEDDDLDKHRPADDTPSERDRALARKIMDHKFMLEYMTQTLRDTCWPEDDRIPERQNRPSTTVKPTTPAATSRPQHESHKKRRIAGPERTHATLPIRLHGSTRRLRSSVRTAPVCARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPB0</accession>
    <name>A0A4Q9PPB0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_932005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020857877" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="20226" checksum="56C81263FC5A1EF2" modified="2019-07-31" version="1">MFAPVAVLVLAATSAFALPRSLPRADDPCAKFGGAAFGNAGPFTMVTLDLSNRTNLLILGPAVGAGSSDPSRRSLVTVETFPTADTPTYKLVNGGLFAMTNNVTVGAAGLAPASGAPVYFEVGSTDAAQVYCGVVGTSPAGHDPANPALVVPGGSNGFAICNATSSASKSPLQVLIFDAENNANQGYDFSTCNPVTVQLVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQM4</accession>
    <name>A0A4Q9PQM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_931378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQM4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7160" checksum="F11A7EAE80136B84" modified="2019-07-31" version="1">MTLFMTQGPSWDPGRSSRESEGRGMNIVKPPYTAQMIIVSFPSVLALTVCTARTSGAFRVRQRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS21</accession>
    <name>A0A4Q9PS21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_563154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS21"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12316" checksum="9ADEB969642A63E7" modified="2019-07-31" version="1">MMFCAPQYLYSERVNSSNKQPSLRGISVNRTTTISTSLMSRLMLNIRDPAMREPHLSEPPSAATTWVFATVALDTFATETGSSSLATYSEAPSHTGGCETDPSVPRGLENNGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS86</accession>
    <name>A0A4Q9PS86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gylcosyl hydrolase 115 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_853555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS86"/>
    <dbReference type="STRING" id="114155.A0A4Q9PS86"/>
    <dbReference type="OMA" id="PAMWNGM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.520">
        <property type="entry name" value="Glycosyl hydrolase family 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031924">
        <property type="entry name" value="GH115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041437">
        <property type="entry name" value="GH115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042301">
        <property type="entry name" value="GH115_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37842:SF2">
        <property type="entry name" value="GYLCOSYL HYDROLASE 115 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17829">
        <property type="entry name" value="GH115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15979">
        <property type="entry name" value="Glyco_hydro_115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020795393" description="Gylcosyl hydrolase 115 C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="domain" description="Gylcosyl hydrolase 115 C-terminal" evidence="3">
        <location>
            <begin position="822"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1007" mass="110463" checksum="ADD028E120EDC44F" modified="2019-07-31" version="1">MARLLHWSHAYKLGLVLLAAAGGVLAIGQDACVAFESKSSTFPIVSKHEAAPILLSADEWGGVQRAAADFASDIHEVTGVKPTLKNVTATVSSFASAGSKAVIVGTLGKSTLIDTVVSNTKLDVSSIQEKWEAFLTREVTNPLPGISSAYVIVGADKRGTIYGLYEHSEQFGVSPWKWWADVPTTKHSELYVPSSGCSHGTPTVTYRGIFLNDEQPALQNWAMEKFTNGTGAALTGSPFNHYFYTNLFELILRLKANSLWPAQWSSAFGVDDTQNQPLADWYGIVMGTSHEEPFMRSVPVEWGLFGNGSWDYAGNTQNVYNFWKGGIERAKNYENVITIGMRGAGDVPLSEDQNIELMEKIVSDQRSLLGDVFNTTDVTKIPQVWTLYKEVQGYYDDGMRVPDDVILMWTDDNWGNVRRYPLVGERGRSGGSGVYYHVDYVGDPRDYKWITSSQIEKTFDQLSTVVARNATSLWILNVGDLKPYELHTEFFLTYGYDASKWTPSNLNTFVTRWAQREFDLSASDAVAVASIIGTVTRHNARRKPELWNSTTYSLTNYREAEKVLASLKAAAATSTRIYNSLSSSTKPAFFQLVQHPAQATYTLANLWISAGINNLRASQARISANDYSEQVEELFNEDYALEVNYHIILDGKWDHMMDQTHVMYYYWQQPMANTMPPITKVQAKKQALAGAMRIAIEGSSGAWPGDNVNNCALGYNCGNPSLTIDPYLPVGNRYVDVGAGGPSTFTFTAKANETWVKLSSAGGTISPSNPEQRLFLSVDWTRVTGVQSAVVTITAKVPNQPSLSVPVTLTANHTLVPEGFQGFVEGDGTVTIEAAHAARNTSVQSIAWTEIPGLGRTESGITPWPRGGNELNFTAGSGPSIEYDFYLFNTLKGQGNVTITTYISPALNGLGDERPLGFALQVDDGDPKTNYFVPATPAGKYVPTPWNGLDGWVANSIITVQEAFDVEPGKHTLKLWMIEPTVVVQKIVIDTGGVKASYLGPPESIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSH1</accession>
    <name>A0A4Q9PSH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial 50S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_929441</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSH1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PSH1"/>
    <dbReference type="OMA" id="HITIHTT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="300" mass="33233" checksum="99CB656033A54AFA" modified="2019-07-31" version="1">MSAQVATRTTRAVTTAGRTVRRTRPAPQRPPLKRDEKGLPIPHVNVIVRDTHRSRLADHYHDTLQEDLMYMTYVHEPIPRKPPRPVRLTYDPNDPYTKHRHNPPLGGNRWAKQPPPPSAPDNIIQLERIQIHTQIKSAVASRTNLLGPIMAFRAISGATEQGGGQHTAEGVQLVKGRKNLQGWVRPGLPVGVKVDLKGPQMWDFLSVLVEFVLPRLRDFQGIPLEGPSSRLDKPNAASGVVSFGLPPTALGLFPQIEVNFDAYPSTFGMHIHFITNAKGVGAQNRARALLSGFQIPFSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSW3</accession>
    <name>A0A4Q9PSW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_550074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10009" checksum="445D94B256134A9B" modified="2019-07-31" version="1">MDTSPHTQDSLPLPRIHFLHPGFTSFTQDSFPLSRIHFLYAGFISVNPGFVPLTQDSLPHTPHMCPYTLGSALPLTPGLARYRFTPSSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUS0</accession>
    <name>A0A4Q9PUS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_782743</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUS0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6746" checksum="D9B2E8A37DBF2C9A" modified="2019-07-31" version="1" fragment="single">MGASRCCALGCTWTRSVREAEARLVYEQNNRSEGMLARLGDVRGECSDAHRTDDRLQPFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVE0</accession>
    <name>A0A4Q9PVE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_819325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVE0"/>
    <dbReference type="OMA" id="MQPRRAN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020537728" evidence="8">
        <location>
            <begin position="19"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="110"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="141"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU58460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="422" mass="45231" checksum="6CB7162C01BE44D2" modified="2019-07-31" version="1">MYSKACAIALTLVLPATASPVVEGLGIRVPFQKRSALADSRGIFDYAKAVRQVVHDHNKHRSNLQNVERHVGRDAFNEGADIKSLMELPTHALERRQSEGLNDEDHDEFWAGNIAVGTPAQPFYIDFDTGSSDLWFPSTKCTQSACSNKHKYNLSVSSTGKQTDRQFSIHYGDGSAVSGPVFTDTVGFAGLTVKDQYFSAATTLSDSFGSQANDGILGLGYPLLSNIQKPPFVNSAKAQGVIRQAAFGFKLGNVGSELYIGGTDKTQYTGDVEYHNVVGNTGYWQIGGGQLTIGSKIVSTGIKTVIDSGTTLIYGPPDAVAKLYASIPGSSMHGANTGFYSFPCDKVPSNVAFSWGGKQWTISAENFNAGQKSLLEFTCLGAIVAKDLGLGDNVWLVGDSFMKNVYSAFSFENNAVGFATLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVZ7</accession>
    <name>A0A4Q9PVZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_926706</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVZ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="217"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="38516" checksum="EA40ECA96FA6547F" modified="2019-07-31" version="1">MTLSESRIPVLSNKRKRPIDDTEYGLKKASKEGETRESGRKALRIVTDVAALEVLSPDLDELLSSTDSEGDSLFDEPSPRLDMPDIDDLRTAMTSTARGASELLPDSGLFPAKRTAPSIQGLHFDSTLLLPEDIQEDLMWTCIRTFFHEGTGNQVMLFERAPSSDPEGTSSNPSTKLPSFLADLLSTLDTLLRPRVPPEVHDVLFSPAPASHQGPPRARQAIINLYWPGEGIMHHVDLPHRYGDGIMGVSLGSGCAMQFTKVPMNEPPSSPPDSPSPSPAPGQCALYLPKGSVLIMTEEARYGWTHGIEKRFDDWVEESPGSPQNVLLERDIRLSITFRWLLPGADVVGPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW49</accession>
    <name>A0A4Q9PW49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_818482</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW49"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="533" mass="58440" checksum="38F95D231B1BD55D" modified="2019-07-31" version="1">MGKHARKKQKISDQVEVQPLGALAAFEDPGAKDEEELRLESFLFGSADEYAAPVHDDQPGFTDDVFVDDVFVDDGLHADPTHGTGQKQSVWTDPDDPALEVSLASDKRRRKLRDAFAEDTVDGREYECRLRRQFEKTNPTPDWATKARKRLHTTVAGKRRRVSIGSEPEEDSEQEGLGPGLDSLLSGTGSVVAGRHARVLPQGILAIERLRDANLSAKAEGEINVVQFHPSPQVPVLLTTSSDRRLRLFNVDGHTNPHLQTLHIPALPLNNATFHPGGTSVLLTGPRPFYYTYDLQTGTTQRSPRGLWGTTFTNTNQAAQDGSMEVCAFDKTGSVLAVAGRRGHVHLVDWRTGGGQVVGSVKMNAGAKSLWWSGEELLTLSEDSEVYVWDVGQRKCVRRWKDDGGYGSQLLGGDRTGQYLAIGSKVGFVNVYGSDAAQGSIDRPKALKTLGNLTTTITSLRFNHDSQLLAIASNVKKDQLRMVCAALIIVVNKYTNALLLESDTFAFPNRVLQLANIQHPARPCDECGFFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWA1</accession>
    <name>A0A4Q9PWA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_818417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWA1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWA1"/>
    <dbReference type="OMA" id="HCTNDAF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF55">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="393" mass="44735" checksum="618CED607AFE8CCF" modified="2019-07-31" version="1">MLTGKIEKPWLTEKDTRLTLAYWIVYFVAFLGVAGGAIRCYFAWKQTLHLGNLCLVMEDNFDTFDLENTWTQEVTMSGFGNQEFEMTTNSANNSFVRDGHLYIVPTLTSDVIGYNNVLGSPPYMFNLTGCTDANSTNCGAVSNASANVVIPPVMSARIHTKNQYAIKYGRVEISAKLPRGDWLWPALWMLPVNDVYGPWPRSGEIDIMEARGNGPEYQAQGIDYVRGSLNWGPFSWLNGVSKTFGWWTNRRKTFADGFHSYVLEWDEQFMRIYVDSRLTYMLYLRFNEPFFKRGDFPSVVSNGSNFIELEDPWASGTRNVAPFDQPFYLIMNVAVGGTNGWFPDGVGNKPWLDGSDIAMTEFAQAQEKWYATWPTNIEDRALVVDSVKMWQQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWF3</accession>
    <name>A0A4Q9PWF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWF3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18211" checksum="B9DE099CF728640B" modified="2019-07-31" version="1">MRSHSQTLNYGTHAISPHDFAAHRPSSSQLLSLQLTVPDPPQVPHLTLSGAPMIRLGATTSTLRPGLALPRPIGCYPIPKPLTDSHSDQGDVTPCLASCLCRALTVDCARGPRPTAGAGGNTNSAPADHYASGMHSSKRTSGWFPHACLPAPRIALQHQECRMACPSQRPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX73</accession>
    <name>A0A4Q9PX73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF1682-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_429234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX73"/>
    <dbReference type="STRING" id="114155.A0A4Q9PX73"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="383" mass="43600" checksum="2DDBF4E7D3DD0958" modified="2019-07-31" version="1">MAALNIAKFLTPQMPVVTPDYDGLEYKWKFLTFRPAYFKNELYFLGAFLFYLLFYYVGKTANKGRANKWFETHLPLYKTQFSRPANAEGLVADGNSDFFAFSTGRRALTSLHTTFTLRPRHDLLQIIYQFGRGIVELDYNVYDKVELEFTFREPVGKEGAVPEAVWAIVAKDEMKQLRNDRWDLTFTKTTEHSALPPSLVVMSEFADITTNLLKPYGQFQLAQVLSNPATLPYFRSLSLTDQPRARPPVPLDPSERSKRLILSLAVPPNADAAATLPLVTAAFQLVDIIAGEGKLPGVRGGLNAALRPETRTKLRKAREEVEKEIRDEAQREKKEEAEEEKAAARKRARDERVSKLSAAEQQKVLDREKKRLLRKSQGKLKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY60</accession>
    <name>A0A4Q9PY60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_407701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY60"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16199" checksum="FEB723406C4ADEF9" modified="2019-07-31" version="1">MSATSLTVDGTRYVRAQIPTPARPRASIGSGSSACDPWTVPVVSHGRIGAVPTVGMIAAVLAARGCSICISISLFCCSRCTLALLSLMADGGWSHLRATSSRRTATDLMRSCDAFFAFRSRLPHAPTVSLRENLCQFIQGIRIPNPAVRVGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYP5</accession>
    <name>A0A4Q9PYP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Homocysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_924443</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYP5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYP5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008898">
        <property type="term" value="F:S-adenosylmethionine-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033528">
        <property type="term" value="P:S-methylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051486">
        <property type="entry name" value="Hcy_S-methyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015:SF1">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE-LIKE ISOFORM 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46015">
        <property type="entry name" value="ZGC:172121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="6">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="389" mass="43142" checksum="91D9554666A67488" modified="2019-07-31" version="1">MLALDMTSLSVQGTTLEDVFRQKLGYPLWSATPVDKDPEAIISAHLAFLRAGVDVITTSTYQAAYRTYEIAGYSREDAKRLMLEAVKLAIEAKRRYLQEIGQNGGTDAEPSRRVKIALSLGPYGGTLSPAQEFNGFYPPPFGPASSGAFESNVFSDTEEGLKQLSMAIEALEEFHYERLEVFAENREVWDEIDFVAFETVPLRREITGIRRAVAKLQKTKGLEQVARSGASEVNTMKRWWISTVYPDGRYPEMKPEGGQATVAEVAEAALLGEDERLSVPWGFGINCTSPEFLPPLLQEARDVARRSWELHGVKPWLVLYPNGGDVYNPETHSWLGQREGVSGWATHLCAAVMDNARDGVWGGIAVGGCCKTGPDEISELRNELRNQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZY6</accession>
    <name>A0A4Q9PZY6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_947555</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZY6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZY6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="311"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="394" mass="40953" checksum="3D96CD491046D0BA" modified="2019-07-31" version="1">MSADQSKASSSASSSPQEPPQPPAVAHYPPAAYGGHYPPPGPYPPPFYAYPVPDPSHHDPNNPNGAPSQSVAPFFMAVPPPPPGMVYAYPVPPTAPGYPFAPGMPAPQPPPKPKRKQVKMACTNCASACKRCDEARPCERCIKYGLAETCVDGVRKERKKGIKRGPYKRKNRATSGEGSAEGGEATNEQPAAVPPPPAGYPMPPEGYSFPYVYPPPMGYVPAAPDGQPHPEGANGAPPAMHHPFYPSYPAMYPTPYGYPGGPMPYPPLIPTPIAASPNGTAKPDSASAPPTANGASVSADAGKGKKRSRAKNGEESGRASKKTKEAAQVDVQQQPPNGDSGVAGVDQLEKDQHPPPQPQQPPPPSYAGHVDPSTGSGPVAAFGGPEPRPLMAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q027</accession>
    <name>A0A4Q9Q027_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_364943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q027"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="20109" checksum="EE57718F24AA6704" modified="2019-07-31" version="1">MVCVRSSLARSDRAWVTAEIITPTTSSQSIFPLSRLHTFSAPGGEGGTRFSLIRPWYALTMPATAPAAFSRIGQRRSFSPAMSTTLYRTVTSESWTKGPTAAIIPASNSGMQAGGRGTPPLRVRTPQSRLGQPRCILRRHRRLVTGVLLNPCYSRQLLVPKSRRTPQENARVRPWCSVKWTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q098</accession>
    <name>A0A4Q9Q098_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Serine/threonine-protein kinase Tel1</fullName>
            <ecNumber evidence="4 16">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_957598</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Chromosome</location>
            <location evidence="16">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4 16"/>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q098"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05171">
        <property type="entry name" value="PIKKc_ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038980">
        <property type="entry name" value="ATM_plant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056802">
        <property type="entry name" value="ATR-like_M-HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044107">
        <property type="entry name" value="PIKKc_ATM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021668">
        <property type="entry name" value="TAN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37079:SF4">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25030">
        <property type="entry name" value="M-HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11640">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01342">
        <property type="entry name" value="TAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="16" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="16" id="KW-0779">Telomere</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="204"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="750"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="772"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU60552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="3105" mass="348264" checksum="D852D1242E939AF6" modified="2019-07-31" version="1">MSESLKETLDAIRSNKVADRQKGYNALRVAFDRDSAVLHFDRAGNGKPWLAVFQALFEAFTHECKACERNKAFADSTGRGSTYIRRLGDVASLVRWLTERSLTRLNSFVLKPLLLHLTGAIVDRSAGQLLAPVALPYAKAIKSIITYKPHLYSLKDKTWHELLALAFNVVVGAAPKRRLLEHLVSNDSDGMDVDSGEEVIVEGEGAQSSAGSVAGPSTPRTKRSREDSLPSRSAPRATAPRSSQPVSLEQIEFMSVIAILLRSPTVSILDEVAESDSDRETLLQRKEQDPHVFPRRLLNYFSRFLRIYTGDTSLHPDYLIALSAALSHLTLNCRQAVSRFANESWDALVSMWGTKNQRMKEDLVVVFRLLFPLLTAEPLEDEASTDPTGALASLWTALDSHVHSRWGVHNLSIESLQLHLMDEHGCESSKRAFVAETFRYGWHFDPEQALSWATLELQADCAEQLYLRSESTYVKVVSSRKRVKVENPVLSLLQSIRLQATQQVRTHHLQVILFFVDRHWHVLHDQLQHDIISTLVAFVSFEDAVIQSWTFLCLAAIAHAECASAPQYAVGSLSSKAPAIWDSVWTHAMRRANVPAVSRGACHTAHVLLTHSKRLLSSHRVLIEIESFAKDLDVQGPAYPFDSVCDFMVLCLRIANQDVRLYRMQMEEKVLSWLTESWRIGAERRTSMPLHTTAHIHALLEGITGSSKRVRLQCEMMLPHCAIVDAVAEEAQTKVIRDFQLHARLPPYRRRHSRNPESLSLISSTEDDAADKTTSPFGDSTDLTPPRGRERRISAFLLKSLEELATTVGPNGTSNGFPTAERVRSSLELAVTALCFEASLLMNGTQSNRRVLQAACKLLGSVVPLLTDSKWKAEERRLILHALDPLTRADNDAEDAEWVTLVPPGERTGIRTQVLRKLLSTATASESITAHQRDLQRFVFRSADVQDAFVGVLTILRNLVRISLGQDLAANSQSMAIVDDSDGFGPVRDAHAVTSLSTTRYAQQDQVHNRHIVDACVTALAVVPILQSSSGEPTRDRALTDLVLQAPVDQFLVLGPAYCEQVGRRTLNLSTSILEGLFTQLELACGPYAYSHSEETQLLVVKVLDKTSHVWMEPTIAASAVGQRARLCCWNLVDTLQLKRVGGTLRRCSSRRSWRVIDAIIRFLDEYLAKDPSQEIWVTPTDESGTPDESELPAAVLPALGNDDDIRIRFRIAATSPRLLTVGRLAQRDLMYEVYHEIHKNLSTQQENYEGILTRLLCLSNVVISDASVRRGAYWHLLEVAFYSTVYLRHLKAVLNGIIERMGIETLSDLFNCYASQFAYSIRRARIDLFKFPSDLLGYRDRRECAEATFHSFTPTNLLDEGDAEEVEYGKELFVRHCQAVQKSEKAGLDECFPELVAYEIVYWLNHTPDLQAEAQLEDRLRTKTGYNKTNSSFKDRLQLEADGIVVAILRSFGDQDISLNGPILDALQTAVDQHALGAFNSITQYRALDIVEAHKPNLPFYPTPVILHALEWLRTRVKEVDSPALTYHVLHELFADIEASPLVNEQLRLLNAVSLWVACHHAHFQEESLLRTLTLRAVTMLAQVDLARGAQSLLEWCFANYRTSSVKADYRLADVLIRTSTIAQDFSQTSGDAAVANLGADLLAWVEKQADTLRSRKSLKKQVVRALAAWPRDLPEALRAACEEVQFSDLTSVLVDYGVSSSKFRLVRRIHDLAAQHELDEHFSRSDFWRLKGCIPPERYLVESDIGAFTSLLMLHHGQVDSIGSEQFEPESVRVLHARAAATTVPARKDFPPRVDVHLARSSIVVSLRAMLDVSTAAQVHVAYQTLRTLMSVPSSESYTGPSCSGDVRRELEYLQTCAKPFRKVDAPDLHHVLRSEEMLQLVVDFDSWIARLTTILCDVLGARDPFFSTLAPVLQSNRGFAEEVLPVVVHCLLQLEHQSHSSELLGSVRNVLSEYFSAVLSCGDAATPCHRAIISVVLHLRRFHPSAEVKDALAYNKWLVVDYTVLSRSAIKCSAFTTALLFLEMAAESNSSESIAESSVVEQILFEIYSHIDEPDGFYGIRTGDLRNFFVKRLHHENQWEKAFRYHGAMVESGSAGPSNTDGIVQSMYAFGFNQLALSTMQNFYADTNNTTESSTLAYNLGWRAESWDLPENLGDGNSGATLYLALRAVYRERSPQAVDVILRRAFTQEMNRLRDLGNENFTEIRQVVQNLMCLSQVKQWRGEGIQKALKSRCIDAADWKPFTHIDPAFDFANMEAIMATRMSLIRSARQKEQRLQIGDLKSPFCDALLELEKSCLLCLSERARDVHQSQIALNSVTRAQNLDRAGSPDVDQEFANVLWLIKEPKLAVQSLANLVSSRIADQAAKEAQDEIQRATLLARLGTWSSEASMKKPSQIVSECFGPAAELVMSTSTEVLPPSSDERATVFQQYAIFAERQYHAISKSPDALRWKLYVDRKKEEIKQRGRQMAHLSQTSAEYQNLNREQGRAQTLLKGDLERSREHLSQRTSFLTSAVEMYSRCLAASDKFDEDSPIRLCSLWLANFDSDDPALRFGAALDLVPSRKFVFLAHQLTARLSQSDGDQTNHNQEILQGLIQRMGSEHPFHSLFPLYCLKGDHTSSRTSGITRRQSGRFGTPAPPSQVDRAAAVSDLFDRLRCDPRAGKRVRAVERVCDASLEWAKHPIKHLFGKGTRMPSSLPVPEQVLIRKLKDIQVPVVTAATPIDPTTEYRDCIWISHFDGQYSTAGGVNLPKILKCYGSNGKVYKQLYKGEGEDDLRQDAVMEQVFDLVNVVLRHDRETRRRKLGVRGYKVIPLAAQAGVLEFVDNTTPLANWLRPAHQRYRPTDLTLDEFSKEFMGSNGKYSKQWRANPQEVIDRFARVRQRFQPVMRHYFTEKHKTPMSWFAMRLHYARSVATNSIVGHILGLGDRHTSNILIDNKTGEVVHIDLGIAFEQGKLLPQPERVPFRLTADMVDGLGISGTQGVFQRCAEETLRVLRDGSETILTVLEVFRYDPLHSWTASEFKIKRAQAAQPDETAQLTGEAFRFAVGLDMASGATDEAADRALSTVARKLDKTLSVEYTVNELITEASDPANLALMYIGWAPHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1A5</accession>
    <name>A0A4Q9Q1A5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1037621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1A5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1A5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="569" mass="63323" checksum="37B6AD86FC5530E5" modified="2019-07-31" version="1">MNPDSYSPILYNAVVFALHQLYYHPPGQLAQQMAAAPQQGLAGCWQLLPQQSPYNPLQPRLLPPALTAMGPFVPQYPQGFHVPALAQQSWFQDFLQATQRVVKEEGNPLEPELSVDDEITLVEAFKKGTEHGLTSLQVFQELNNKNQHSDIEWMKIFVAHVRKLYPKVFPDAVPAPSLVGRPAGSENHPSASEPTGQQPQDAGQASASAALTSFTRSKPPYDSGDRAQPTTKAPTEARICSPSTPVAFSSSKIKSERTAGIFYGETWIPPFDGSEKPPYPTRLGEPGTRFTQEEKVFFIHWLHWRLREEGLTDKETLFKELERELPKRTADTWKRFWAENPDAPNAVYIAARKRAERPDATRGSLTSLAELSDANSDEEEQNLREDGRPLIDKGEAKPVATPSSSSESKSKRSPSLPVTDTDLRAMARYKFEKDAVWATRRYKYAPWDDFATRPENARRSLTAWKHIARNPKHGVVIDRYVQEYRSESEGEKPITSKQALPAPPPQTSAATPSSAVPKQDLEPATLKLPAHMEASSESGPSVTAQTTSREINVRWAVSDQDVIDLTIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1G3</accession>
    <name>A0A4Q9Q1G3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cystathionine beta-synthase</fullName>
            <ecNumber evidence="4">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_874660</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4"/>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1G3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1G3"/>
    <dbReference type="OMA" id="CMTADTG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="400" mass="42480" checksum="9B1A6B7D526FA8D2" modified="2019-07-31" version="1">MARTSQILDNALGAVGNTPLIRLDRIAKEEGLQCNLLGKVEYTSAGGSVKDRIAKRMVEEAEKEGKLIPGHSVVIEPTSGNTGIGLAMACAIKGYSVIITLPNKMSLEKEAALRALGAEVVRTPTEAAWDSPESHIGVAQRLQREIPGGIILDQYRNVNNPLAHEYTTGPEIIEAVTSTPSTVSQPSLGKVDVLVAGAGTGGTITGLSRAIKKKHNKDCIVVGVDPKGSILAYPDELNTDSVGAQYVVEGIGYDFIPDVLSRDPADVDEWLKTSDDEAFAAVRLLMRHEGLLVGGSSGSALSGALRWLRSDKGRAIAQTKGLNVVVLLPDGIRNYMSKPWFLKMALEAEPSPLARRIAEVLKTSESNVETNVDGLANGIASRTTATNLENCPNAADETSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1K3</accession>
    <name>A0A4Q9Q1K3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_946819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1K3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1K3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="251"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="717" mass="79396" checksum="F31C93D428BCA6F7" modified="2019-07-31" version="1">MSLESITASLSKLSITPAATVSHGPTNSPQSWRDALEASGSAPQGFELIKTLVYKPKTAKTATPVPVFVIARESSDVPSGTLGKHLNLKELRLASEDLLKEFFNLDKNSLSPLAITSETYPKITTVIESSIASSTSVFAVRGLSSDSTVFLSGKDLYAYVKQFATEGAPTLHEVDVATLQATADSAAAAVRTSAPVKKEKEEAKIEGAVQIAIGVKKEVDFPTWYTNVLIKADMLEYYNVSGCYILRPWSYSIWETIQEWFNSKIKAMGVQNAYFPMFVSAKVLEREKDHVEGFSPEVAWVTRAGKSELEEPIAIRPTSETVMYPYYAKWIQSHRDLPLKLNQWNSVVRWEFKNPQPFLRTREFLWQEGHTAFLTKKEADEEVLQILDLYRRVYEELLAVPVIPGVKSEKEKFAGGLYTTTVEGFVPTTGRGIQGATSHCLGQNFSRPEMFNIVVEDPADPSGQGKTYVWQNSWGLSTRTIGVMVMIHGDNQGLVLPPRVAVLQVVVVPCGITAKSTDEQRKAVNDAAADLAAQLKAAGIRAQADLRDGYTPGYKFNDWEQKGVPLRLEIGPQDLAKSQTLTARRDTGAKAPVPLANIAQTVSALLDTIQADMFRRAQETYFARLREVRRWEDFVPTLDDKCVVVIPWCEAEACEDDIKDRSAKASEPTDERAPSAGAKSLCIPFDQSRWPKIEPGVTKCVGCGKDAKRWTLFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1L0</accession>
    <name>A0A4Q9Q1L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_922275</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q1L0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="890"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1279"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="892"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1321"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU60880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1344" mass="152591" checksum="4AD562CADD4FDACF" modified="2019-07-31" version="1">MESFDLTEELQAITDLPTYSFNNEVDVSSLDHSAIAQVLDPAVDALAHSSESIVDPSVFDAYRSLLKHASALQGVHMTKILDSLSSAYQAEVEATSRDIDAEDQQTFMAHKVPLEIYAFLLHWLVSVAEKVKTSGEDDAPAPAPKPKRGRGGKPATSRSTARKAAEEWTWSVQIPATLALINKVLRLKTQKIWQTAGEREAFINCVLRPVYHITENEQYMKQQQIRFGVYKAICLAVKHHAHGLAAQISIMQSLQYYEHLSEYMAECLDVLAREFDHSQMGDEILREIANKNFSGQDSKGPRAFSRFLIRFAELAPRQVLKQLSLLLSQLDSESYPMRMALVEVIGSIIHELAETPEDESDSSSKSKHLKQINGLYDLLIERMMDVSSYVRVKVLATLAKLCDGSHKFPQQRLAITRAAVEALEDKTASVRKSAVSLLVRLILTHPYGMYGGLLSETEWKVQYKEVSDMLEKMEGNLGKAVERNDEEESQAEDEHDEDEDDEEGEDGEEDKRKKKRKAKRKGDESMEVDEEEDDDTEDVEDDEDVQMRHGSNAESDAPKPRKKSKKKPRKSELDLNALANEAAALGSLNENQHLEQKLRKKYCLDALEFIRQVEEGMQTIQRLLASANKLEQLEAIEFFRVTYEYKFDAAHEGIKKMLHLVWTKDNNATGEDGKEVKSVRSRVLECYRNMYFEPVDGLDAKQQTNRIAKNMIEMTYDATLAELTSLEEMMRQYMDDNFIPDEVVAKLWQVYSSDRPLPRAQRRGAVIILGMLALAKRQVVADRVETLVKVGLGERGKNDLTLARYTCVALQRLNGSAKKVKGSLLDKTLRLDMENPLFRKLQDAIERPCRSKEWFPMAEQAINTIYALGERPDLLCGKLIKNLTRRAFGRKSATSASSQQDQNVMDQDEEDVDPDAPHQAQSQKDDAKDAGDAFELSQLFFIVGHVAIKQIVFLELVEREWKRQKHEKEMAEKIGGAAAKSKEQEELDQVAGNAEDEIGERVQGMREHELLYGPQSLLATFGPMLVHIVGTPKKFKNRTLRATATLAFSKFLCVSSQFCEQHHRLLFKVLETSNDPGIRSNIVIALGDVAVSYSSIIDESNDELYRGLGDSDMVVKKNTLMVLTHLILNGMVKVKGQMGEMAKCVEDEDERISNLAKLFFKELSTKDNAIYNNLPDVISHLSVGAHAIDEEKFQNTMKFIFGYIEKERQAENIVEKLCQRFRLSEDPRQWRDIAYCLSLLPFKSDRSVKKLVEGLPFYRDKLHEETVFARFQEILTKARQNKSANKPDAELNEFEGILEESRRQGAEDQDFERNVQTQKNVAKKRAARRTQRKKPAATQHDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q236</accession>
    <name>A0A4Q9Q236_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1037254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q236"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="78" mass="9045" checksum="2AE5CC6A31ADBE4F" modified="2019-07-31" version="1" fragment="single">RTSITGGPHDNICCRPPGLRDLRPSSRKRHFRRRWKEEPQGRGQRCAGHIIAAIQVPQGPFREHRWRPRRGCKSQAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q294</accession>
    <name>A0A4Q9Q294_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA mismatch repair protein MSH2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA mismatch repair protein Msh2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_921548</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q294"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q294"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003810">
        <property type="entry name" value="PRK05399.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="765"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU61130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="962" mass="106079" checksum="DA96190036F621AB" modified="2019-07-31" version="1">MYGKEKDAEYEIDNSSHPGFCSFFAKLPPRSPETGTVRLFFRNEYYSVHGSDAHYVATHLFRTNSVIKYLGGRAGLPSVTLSESLAKSFLRDALTSKQLKVEIWAPEAGQGKKATKFVLDKEASPGNLSAVEDLLFVNTDIVSAPIVMAIKIASTPAVPGSTAVKTKAVGVAYADSSTRELGVADFVDNDLFSNTETLIIQLSVKEAIIPTGTNSGTTERDFDLKKLKEVLDRCGVVITERKPSDFTVKNINDDLVRLLNASAMPSSSTDSAATIPQLSLPTAPAALSALVSYLSLLSDPSNHGAWSIRTHDLSQYMRLDASALRALNLTEAPGNIGSNKNTTLFGLLNKCKTAQGSRLLGSWLKQPLVNRHDILRRQSLVEAFFEDANTRRILQDDYLKLMPDMHRICKRFQKSIASLEDVVRVYQAVLKLEGFISTIESMETSSEDQKALLKEIYLTKLKEFDGSLSKYSEMVQQTLDLDELENHNFVIKPDYDARLQSLADKLAEVRDGLDAEHRKVGKALGRELDKKLHLENSPTYGYCFRISKNDVKLLHDDKKRYIELGALKSGVFFTTPTLKGLSTEHTEITEQYSRTQSGLVKEVVNIASTYTPVLEALNNVIAHLDVTVSLAHVAVNAPETYVKPEILARGSGSLVLKEARHPCLEVQDDLSFIPNDVEMIKDESEFQIITGPNMGGKSTYIRQVGVIALMAQTGSFVPCASARIPIFDSILCRVGAGDSQLKGISTFMAEMLETATILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEHIASQIHAFCMFATHFHELTALDQEISHVKNLHVVAHVSDSEEGGGDRDITLLYKVEPGVCDQSFGIHVAKLANFPESVVKLARKKAEELEDFNHEKAEPELPADVVEEGTKIVEEMLRAWTSKSGHDGEDVVMADDDASPEEQLEELKRCVERFRPKIESNPWAQSLLASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2L1</accession>
    <name>A0A4Q9Q2L1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_873655</name>
        <name evidence="12" type="ORF">BD311DRAFT_778792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BIG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143429">
        <property type="protein sequence ID" value="TBU27730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2L1"/>
    <dbReference type="OMA" id="ICEHDAV"/>
    <dbReference type="OrthoDB" id="10029326at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037654">
        <property type="entry name" value="Big1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28285:SF1">
        <property type="entry name" value="PROTEIN BIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597647" description="Protein BIG1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU27730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU61211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="284" mass="29950" checksum="991349C655680D31" modified="2019-07-31" version="1">MAGRALTLLFALLPAAASAYSRTHPVLAWSSRNSRALTSSAVSEAAKNSHAIASALYTNNDICDHDAVIVVNHQGLHASDLRTLSSSCHVARALSSAPSSLQFAYVESEERNANPFLDLSSILSERCGSRAVSHAPDLGEFDIDAGKGKHVVSISLPALEDGEIGASRKSSMANHESWLSGELSKIENIFSDYLVIYAGAPGSSLGVRQSSSSSTFDAEVVASPSGGILKRYQLLTPGLILVLLVSLFILVPVIFLGVSALSSIQSPLTNEIPKGFSAEEKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q376</accession>
    <name>A0A4Q9Q376_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_219307</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q376"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14621" checksum="EF4056F2B512B82B" modified="2019-07-31" version="1">MSAHEDSKQAFFPASLELIAPLIVPTFSPPMPLCSLTPNGSLLPASLPSSKSSSPECPPNIPNLLVHISRGFVQYLEPCDIADFKAAKDLLPKYLDLSRTWTKQEKASISGLVTATASGFPIFAKYKGHWHIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q420</accession>
    <name>A0A4Q9Q420_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_812462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q420"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="30"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="360" mass="39994" checksum="475B541102E7886A" modified="2019-07-31" version="1">MPTAAVDDHGSVLYYEDSGAPSTSSGYVTLVLIHGTCFHGAGFRPLIPLAKEHNLRLVLLNLRGYPGSTPYSDAELELFRGALDDQQAALQTRGFEIATFLRWFIENENIPKIHTTAGSDQKSGGLSILAWSGGNSQTLPFFANADKLSEYTRALLGAYIRSFIMYDPSHTAVGVQPPPGLKSLLFDPMASPEEQALQFGLSVSAYYPPFTLPNSIHDTTSYVPRGPLNDPQPTTAKLTDQEIRDLTHPAIFERTQHALWSPTLSSLYEKNALRALFDCRLLDDSSGAKKKVWPGVRVHVVWCDMTAGELAWAVAVLRSRYRESDPDARREIDFHKLEGANHFVHLEEPQRFIELLKKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5I0</accession>
    <name>A0A4Q9Q5I0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5I0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="431" mass="49404" checksum="06827732995BC3D8" modified="2019-07-31" version="1">MISTIPFDVACTITDHLDGDLTSLASCTLLCSTWLLASRRHLFRKLDVWSNLEDGSFATFDEFLKGSRHVAEYIQELYLGWDRRLWKQSEAPLAYPLRGKKPARISLRRLHCIVQQLPLLRKLVFDEVGYTTDGFVVPSFPARPAIDNLEINTPHFRADRDDPLDVLRVLGIFSEIGVVSLSAWWEGALTVKPEVLMRDFVYPGPVEIHDLKTHHISSSWLSLVSCAILKTGSLRKGGTLKTLTLHLDSSQWDEIAVVVGWLLREAGQNLRFIRLDPLSLLEDHDGSNRLWGRSNFSCTALVSLVLNLDYSCYTRNELGIRLGKELGFRIYQELLANDCPPFLERITFRVKLYKELEDRDDLFSMPWNTMEEVLLNSGTLKEVVIDFSTGSYDGREKFCEMMPTLDKKGMLTFRYHEVGDAKSSYWWDLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5P7</accession>
    <name>A0A4Q9Q5P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_810233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5P7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="255"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <begin position="336"/>
            <end position="357"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="6">
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            <end position="416"/>
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        <location>
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            <end position="450"/>
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        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="493"/>
        </location>
    </feature>
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        <location>
            <begin position="539"/>
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        </location>
    </feature>
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        <location>
            <begin position="539"/>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        </source>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="563" mass="59575" checksum="68E2241CA39C49C2" modified="2019-07-31" version="1">MSTTSPTDVALSRIPTGSEVTVNTEPQNTGFRKGSAFWLSFTAILVCTFVSALDLTAISTALPTITDSLAGGDKFVWVGAAYGLASAAILPLSGRLADAFGRRPVMLASVGLFLVGSAVSGAAQNMNMLIAGRTVQGIGSGGILNLSEIIVSDLVPLAERGMFMGIFSGVWALASGVGPPIGGALSQANAWRWIFYLNLPLIGIAFFLVLFFLRVRTPPGSVREKLARLDVAGNLIIIIGTTLALIGLTWGGVAYKWSDAHTLATLVIGFVFIGLFFIYEWLVPKEASIPWDVVSNRTSVSAYLGTFFHGITSTAVFYYIPVYFQACKGASPIHSSVQTLPVTLIIAPFAFIAGTSVQLTQRYRWANVTAWCLLLIGFGLLSTLKAGTSTGKWVGYQIVASAGLGLLFPATVFPVLAPLPVSRNASALAFFSFARTFAQTWGITIGSAILQNQLDKTLPPQFDAQFPAGVQIAYAAIPVIGGLAEPLRSQVRDAFAASLKVVWQTMIGISGVGLLSVGLMKEVPMQGQVDETYGLHHETKAPTESIDPEKQTRAEGGAAEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5S5</accession>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="TBU62460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="17235" checksum="F7D77B7D3DE8DAE8" modified="2019-07-31" version="1">MTIRAVDSYSARVHEGSRVRMTYTRRMAWPTFPARHDVPKHRTLCNQQCGRCDCQGRPIQRKRRTLGQTRSNGQIWTVSCHDMISGLRSHTRPILSRAPLSRAHLTGRPCMESGSDVRPGTLTFIYPHRNVSVLERSSQLHTNRSTAGRGR</sequence>
</entry>
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    <accession>A0A4Q9Q7G6</accession>
    <name>A0A4Q9Q7G6_9APHY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">BD310DRAFT_1027774</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="TBU63100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="266" mass="30321" checksum="B07E54A7B3BF1D18" modified="2019-07-31" version="1">MLHELHVDERVGTATPSNSTRMVRLYVVMVADIPQLFHTQGASAAAEKSSRHQPLHNYQMLVGQQAYLAEAKAQLMTPIDAEDMLFVIKFVEEVHILKIRTEKQGAAAFVKYLSRLFQDYVKEDGLLGRPDKELWAEVDCSTAHGLETPYAMVVVDACKRMFLSHEYESTQKMTCRPALIIIVKDPYVNVYLAYLVDSVVWAQLHTIRLVDEDQLVIQLAKKFMDIRSMGRMLRESYAMVNIRSALSRAPHFFPKPTPPYGVVFTD</sequence>
</entry>
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    <name>A0A4Q9Q7K8_9APHY</name>
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        <recommendedName>
            <fullName evidence="6">BRCA2 OB1 domain-containing protein</fullName>
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    </protein>
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        <name evidence="4" type="ORF">BD310DRAFT_945847</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
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                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
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        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015252">
        <property type="entry name" value="BRCA2_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036315">
        <property type="entry name" value="BRCA2_hlx_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09169">
        <property type="entry name" value="BRCA-2_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81872">
        <property type="entry name" value="BRCA2 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Breast cancer type 2 susceptibility protein helical" evidence="3">
        <location>
            <begin position="672"/>
            <end position="730"/>
        </location>
    </feature>
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        <location>
            <begin position="736"/>
            <end position="857"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="53"/>
            <end position="110"/>
        </location>
    </feature>
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        </location>
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        </location>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
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        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
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        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
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        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1121" mass="121165" checksum="49F9F158159FF984" modified="2019-07-31" version="1">MTKWHLAESPEPESARKRQRLSSPTYDEHFPITQEEMSAFDEIDKQLSQRALVLPSRSRTLSAEETEDVELTTANHGASGEGVMGEGDRDGPAAQEWSSSPLEKPSTTQDRADEDAFFTGAGGGSGFVSATTLPSKPSVDSLAPAASGFTSAAALPLVLKTAKLRASGSFTSKPPDASNAHANSGEASHNGTITSISPTLGGFGPASALPARPEDPCDDRPSSPPPPQPDYDSWFDSDASALPSDALGFKTARTILEPLEAGEGHASQAPVFAGFTSVSGLVQSQSTSHGGSGDSAPEVVEPSPSASFATGFASAASIGFSSAAKLTGGKSAWQAPSAEALARAAQKMKQWEEEFVREDVSTSVAPAHTNQDIENTRAGPSSSVPQPAAAPSLQTPLRPALRPMENSAPSPAQLPDTPLASKNPTHYTNIGGGVQMKNKQFKSPLINKQDRPASASAARLRSSLNPVRASSSKLPAVFTFGAASTVPTAVPATPARPAPAPESGTSIVTTSPSKGKSLGMTPRRLPGGGLKSAGKAKFTTPFKLGMAPGEAGRTQLGAKAKAEASVQTPLRVDVCGTPSSSAKGKSVSVARKEYKFFDLNPRPDRKTLASSGLRPQSYTGDELEDMGINVEELREMSPAMAIYYSFYSAELTNDSAEPLQLGPEAAFVQLKELGCRLATQQWVTNHYGLILWKLAGMVCLEPESELDPKTKRWCWREVMRQLRYRYERELNGGSRPALRLISTEDAPAACPMVLCVSSIITWAPAVVDSEGRPVEPHPELEVTDGWYRLRARVDRPLARAVRRGLIKVGTKLAVSGAKLGGDRKESCEILDAYDSTYLDLSGNSTHLAPWHAKLGFAKDPFIATLDSLTPDGGRVPAMDLIVTKAYPIAYLEFIRNEDGSTTKLGPRDEKEELRAQDEWLTRRDIAVATIRADLERQIQSLEKISEQLYGIAGPRFEDKVNKDDPLPSFIEGMYDEMIEDVSRSPRDFFDYLNYMDAGYLYIHTLDQIRLSKERLGEDIERELQYICPPRNVRDFRVVVAKDARWCRKEPTRTVQITVWDPMRMVFSEGGSPGDIREGQRFLVVNLEVNQPSAWMAPGPGSVIYLISKKSARWTNIRSRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7M5</accession>
    <name>A0A4Q9Q7M5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_809489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7M5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7M5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="37538" checksum="0D0C66B90568B628" modified="2019-07-31" version="1">MLSTFQGHDDATAILLAVHCPSVTLLGISTVHGNASAENTNNNAARCLYAFAAPKHIRVCPGAKKPLIRVERHDPEIHGIDGLGGVEGLPRADDPNVQARLVGDGTPGRALEGMAKAVSSTWNNGQGSKVTVVSSGPMTNIALFVSVYPDLVEGIDEFVFMGGGVGMGNRSASAEFNILCDPEAAQIVLDVPVKKTMIPINVTHTAIVTRPILSQLLAPGSAPAPIGGPLPKAITPLRHMLSTLIGFFAESYKYTFGFIDGPPLHDALTIAYIEKPELFTCKRYRVDVELAGTHTIGETVVDVFNYRSVDNSWGRHGKNCLVADKLDVDGFFQLFLDCIARCDPVSPLNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAK0</accession>
    <name>A0A4Q9QAK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_837982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAK0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAK0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="159"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="336"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="820" mass="92813" checksum="92B242CA1D5DC5B7" modified="2019-07-31" version="1">MRLLDTETGQFVDKDPHDGKTVYAILSHTWNRDGEQTHEQVKEIQEQYSRNIRRPHWQDVLTPSDKRAPLVTSPPLTAAARRSPDLGKSCLPFGQTLKRISRRFRPISLSSPSAEPVASRNGSRENHIPALPLRPSFDLDQSLASSDDHSQWPIDSIWYELELSPKIREACRVARRAGYRYIWIDSCCIDKSSSSELSEAINSMYAWYARADVCYAFLWDVPTKADHRKIGSRFRSSSWFTRGWTLQELLASREVIFLSEDWKVIGTKHTLCDVVEEITNIPYDALLQLVSLDQFSVAQRLSWAASRKTTRVEDQAYSLLGIFDINLPTLYGEGDRAFRRLQEEIMRRIPDQSLFAWKHVYEGPELTADTQGLTFSCDTPRFWIDKHPPRLFSLLSETPSSFVEGEKIGTVGHHDLIQRLQMSRQAFAPEYTFTPLGIRTQFPLIPLSLYLPQKATRYPVNIPASHWFLAILACEHNHRPDHLLGRVCCIPPSASRVEDLFPGNVLIKRGPEHDTNEPDVFYLSPATIERCLPHVELKTVYISHPTRRWQWPHEPLEYIDQLRRPHKAISLILPKITFATLQARGYTVTDFRGPNEENPATHRLTLTTPDLTVIIDFNHHLAHGGWSFTIDAIATLYMPGPMERQKQEVESHTVTWFDNCAFGWDETLSARRVAFSSSEPDPMILELYLQLSATSHYFLHVDVLKYAPATAPPTPELLSEEERQASGAQGSGIEGDGRARGDVKCEDVDVDGRPGVDDSEYELGRLEVPSGGGRKAARSDQADGESSNGPGQSSQTQDEEVSSLTTMANAEASSDARRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAK9</accession>
    <name>A0A4Q9QAK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_865859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAK9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="16"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="487" mass="55498" checksum="3CE26653A8248227" modified="2019-07-31" version="1">MTTSDAASDVVNHNPTSMLESLPPEVLERVLTFSNPRDVSRFAQTCRFARKLVYEPNDQFLWRELYLGRPFDDLRNAIPIPRRQSDTSEPEEEFPMPDIKGVSSPLWQQELQRRTQAELVAGSGTRNARLLQKAYEGFLGAIETATPAIPTGDQDNATVGVRSENLHWVDRILRKTRVLDLVPAYTGAIVHQMRSRLRAYVALSHENSFDVESRARMGRLRSASRAFVYDMRKYQQQTLWGPFRLGEDERTLLVDWEHIEHIMNVVSLKLREVPLASLGYYKKAPFHLDALRANTMIDAHKLPKDDWAGVTGRWRRFVCFMDYRDLYMYNYSLLPPGPHDPSFFDDPFDEALRPVELHLSLISREDYFREPSRIPIDPSMLASSPEAKLPGKRSIGDCEDPVFPTLYFKGVSHGAAATVRGKVSVLSDGAVRWQFVTTYDGRMQWSAEGVQLGHVRSAAGIAGIWTGAHHDRDDPAGPFWMVKLQDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCK0</accession>
    <name>A0A4Q9QCK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ras protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_913442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCK0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCK0"/>
    <dbReference type="OMA" id="MWGCPFV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001763">
        <property type="entry name" value="Ras family gtpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21910" checksum="CAD9F35D7C5E98C8" modified="2019-07-31" version="1">MDSWRVAVLGDGGVGKTALAVQFTLNCFVETYDPTIEDAYRKQLVVDNRMCFVEVIDTAGQEEYATLRDQWVREGQGFILVYSIASRATFDRLDVFRQAMLKVKRQKPVFMLVGNKCDKQYEREVSREEGAALARQFGCEFLETSAKTAHNVERLFTNLVRLLRSTKQQEQGVQGPVRSPEKEKKRKCIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCM8</accession>
    <name>A0A4Q9QCM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_803296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCM8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCM8"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="9">
        <location>
            <begin position="123"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23385" checksum="F7391F172C66EAE4" modified="2019-07-31" version="1">MIDTDPSALPQADAPAFPPLPASAQRSALKSEIRRIPIPPHRMTPLKKDWVNIFSPLTEMLQLQVRMNVQRKCVEIRTSKHTKDIGAIQKGADFVKAYALGFDVNDAIALLRLDDLYLDSFEIKDVKTLHGDHLSRAIGRIAGQDGKTKFTIENASRTRIVLADTKIHILGSFQNIKIARDAIVSLILGSPPGKVYAGLRTVSARMRQRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCW7</accession>
    <name>A0A4Q9QCW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_954437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCW7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="412" mass="41763" checksum="34B99AC8BDC1028A" modified="2019-07-31" version="1">MFKVLVHPHGALSPGLFSPISLLYLPFQLLSRPLLLSFILGLLAATIPAVTAQGFVNAQALTVIDSPAPNSPLHAGSTQGIALDVSAGSSGPFAYNFLEVYLVSATTGTNITVSNTPQLLTQEPGSTVKHINWLVEPCLQSGPYNLTVYESSTLTSDGTGYFTILAVPVQVDNGGVPDPSSCASELNTLQAQPQASSPPPVNLIPGRGNPSGSSTLSSVTATGSATGTATSNVTGSATAISNVTGTATATPTPSAGEIITITAGNGDITIPISNLPGTIVVEPSGGAPPETSTSDVSSGFTTIFKTVAPTTTATLTVTISQPLTVTFEQTFVSTFTASGQTQELTVTQTQTLVSTVELIQTQVQTQVSSPEQAGLLPVNSGSGGMSPLSAVTLLSAASVSAFVYVLCSSFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD40</accession>
    <name>A0A4Q9QD40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAM signaling pathway protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_17310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD40"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD40"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF46">
        <property type="entry name" value="LEUCINE RICH REPEAT-CONTAINING DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="276"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="768"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="928"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1025"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="635"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="667"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="781"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="935"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1055" mass="112775" checksum="25A98288B11880E4" modified="2019-07-31" version="1">MSGSDGEHSARKSSTTSRTAALSPLPSLSLTRDHITDALAKSPDGGATLDLAYKGLTDVGESGAEELATVGHDEQTGTESSVVRIALAHNRLTTLPMAFSLLSRLRYLVLKNNSFTVFPDVLTVMPSLEILDISRNKIKRLPSQPGSLVNLRVFSLTRNKLHRLPPYLAKFKQLTLLKVDQNPLEWPPIPVLEHGKNNNDPQSMSEWIRHLQAWLEDNAGTSGERKQSDDSITSDSGNDSSFLDAPRSDRTPSVHAESLYHARSFSLESDASSYFQLDHSPGPSRKPTMDDGPRLHLDPFFSSRIAKSATPSPRSPESAISPTDDSVLANGFHVGHARVPSHAHHTGNGINGTAKVSLKPIPSSKKSLPDLRPARQHFANGAPRAATHAADHFPSIHSHHPHHSITDEPVSASPISMDRAAPFERPVPSMDSERNSYFRRLSTLSAATISKAIPESLLAVVDAVRGILFALSQIYQTLQHYTVYAIDERLSAVLLKVLGPASSYMTHLIHTLDRFDTVSRRALPSPSICRAVIESCRDNVTVFGKAVSMLSLQLKVLAKHDDARYTRQMLLVLYGAMSEIAAAWAAIAAHVDAVRPYLWDARPPPASKLYASKTPTVRGAPSAGGDKPRPPASAPPHVSSPFLPAQQQQQQQQAPDTPSPQQRSHLRTNTPQQRSLDLGKSQITLSRRHAGSFSSKDVEIGKMLPSYVDPPPTPLMPSSFLPLGGGGYGGGGSGGGSASLMNGVGGHSTPTHGVRTMRRLVLPLGQQQHDWHSHGHGGVGASHSRQGSQSSLLTASHSSPSLGGAAFPAPLSGSSTLVDKEVIGAMRAAVEAAPEIWEMMDEMLDAEEQGDAEGEDGVANARAREEFREVLGRAKDVTERLRGSIAAVQQEGASHPHPQAVDGRALHDDAHLFVKTVIQLSHSLKTRGAVNANGPSSTPTPASSLAASHLNGHTKHAQNPTQLSSTLRTKMVKLTNATQEFVMLLHISSFSPAPTPGLRSYSPMVGFATAAASIVGAQPSPGLSPLATGLPEDGRLASNLSRNRVAGPVGSSKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDE2</accession>
    <name>A0A4Q9QDE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_912158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDE2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDE2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="8330" checksum="238205916F7D2F59" modified="2019-07-31" version="1">MDEEEEEAEVKPEQTNEEDEDRVTFIEEQITMLQYRLAQEKAKKSKTFVKREVSPIRLPSDWSNEVIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDG2</accession>
    <name>A0A4Q9QDG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_943362</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6 8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6 8">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDG2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDG2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09087">
        <property type="entry name" value="Ape1-like_AP-endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00195">
        <property type="entry name" value="exoDNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00633">
        <property type="entry name" value="xth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="280" mass="31659" checksum="C6F6D87049979194" modified="2019-07-31" version="1">MPAQVGFAPRAAGAVRIATWNICGLAAAQKKGFKVYFDAEDADILILTETKVNNPPADPEFTQRYPHRYWAISDKKTYSGTAILSKIEPLSVKYDLPGHPDKSAVKGRIVTLEFESCYVIGTYVTNAGTGLKTLDAKKEWNKHFEVYIRELDKKKPVIWTGDLNVAPTALDLAHPKTNWNKTPGYTEAETSAFARVLNEDGAEPDAPKFVDVWRKRHPDLRHYTYFSYRFNCREKGLGWRLDMFVVSERLEEKVQMCEIRSEIYGASDHCPVVLELAGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE07</accession>
    <name>A0A4Q9QE07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_804265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE07"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU66062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6390" checksum="238B33300D6D26FD" modified="2019-07-31" version="1">MLLCLQEEWLAHSGRWFGFRVRSAQAGRSGTTSYFKCSRCQLMLTGPTMGRYRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFE3</accession>
    <name>A0A4Q9QFE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="3 7">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_911631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NMT family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="3 7"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFE3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFE3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="10">
        <location>
            <begin position="174"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="11">
        <location>
            <begin position="347"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="577" mass="64177" checksum="15B5BFEE19812468" modified="2019-07-31" version="1">MSEPSTSQQKAKEKVADSEQIEENAHPDEEDHSGSDDDSEPDADGDAPETAAGSSSTAVPIDTPGTASKKKKKKRSKAAKALNALKSVGKGKDAIPDEVVKIVLDKVKAEGGEAVAGADAETVRLALEQMKLRDVLQGKTGIGGKNKKDTGGHKFWSTQPVPQLGEAPPEADGPIEPSKPASEVRQDPYPLPKEFTWSFLDINDTAELRELYELLSANYVEDDDESFRFQYSAEFLSWALKPPGYHKEWHVGVRVSSSRKLVAFISAVPVQIRVRDHVLNVSEVNYLCVHKKLRSKRLAPVLIKEVTRQCNLKGVFQALYTAGVVIPTPVSSAQYYHRCINIPKLVDVRFTSVPSTMTLARMIRLHKLSEKPRLLDQGLREMEERDVPQVVDLFERYMKRFSMVPIYNEADVAHQFLSGRGEGPRGSDSWKTPRDGQVVWTYVVENPKTNKITDYVSFYSLPSTIMRSTKHNLLNAAYLYYYATEVAFEDGAEASGRLKKRLEELITDALVIADRAKFDVMNALTLMDNVPFLQDLKFGQGDGILNFYLYNWRTAPLAGLRATSDTPIGRGIGVVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFR9</accession>
    <name>A0A4Q9QFR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coiled-coil domain-containing protein 55-domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1034019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFR9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFR9"/>
    <dbReference type="OMA" id="MSKPLAF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053246">
        <property type="entry name" value="NS_splicing_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47845:SF1">
        <property type="entry name" value="NUCLEAR SPECKLE SPLICING REGULATORY PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="68"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="290"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="387" mass="44138" checksum="229D37723CA66D7B" modified="2019-07-31" version="1">MKVSFSLKGKATPKPVGEAPSLKRTAAFAALDDDEPVDAAPTATGGKSKVAANKQFIAQSVEMSKAMKKKLEEEKKVDSTVFEYDEVWDKMQEAKLRQKEAKEADSKERKPKYISGLLSSAATRRLDHLRAEEKMIQRERELEGDEFKDKESFVTQAYKDQIAELRRAEEEERKREEEEKKKKSKEVGTGMAHFYRKLLEESEQQHEQTVAAAESKPKIGPQGGPNLTITKPVDFTPKSDAEIARMAREQGKEVELNDDNQIVDKRELLSAGLNLSAPNTRKLGLQLSDKNKNAQEHVETHRAVGTAASRREINERRAREVQMQMDEEKQRMQSEKDRREEEERQRIVAKRNDEESVKSARERYLERKRRRLEEAAAGGEAGQAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K0B7</accession>
    <name>A0A4V2K0B7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_822148</name>
        <name evidence="6" type="ORF">BD311DRAFT_663712</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143423">
        <property type="protein sequence ID" value="TBU28293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K0B7"/>
    <dbReference type="OMA" id="EMTFYTG"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF17">
        <property type="entry name" value="DUF895 DOMAIN MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="383"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU28293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="442" mass="47854" checksum="007C8ED05D8E7C71" modified="2019-07-31" version="1">MFSAVSNLGAGGLSDVSLSDTANGVLYGCFAVTGLVSGGITNLLGPRFTLFLGTLGYALYVGSLWCYQTQGTGWFIIFAGALLGISAALLWSAQGSIMMSYPLEKDKGKAFAIFWAIFQFGSFIGSLIALAINIRSGGLSAVSTSTYIAFIVIIFVGIASSFLILPPNKVIRADGTIVKLEAASKPHEEAIGLLKLFKDWRMLALAPMFFASNYFYAYQGAVNAARFDGPTRALNATLEGAGAIVGALLIGYTVLDLKWVHRRTRGYLGLAVVSVMTIIVWSVALSWQVTFNRWDVDHTNNPNSLPFINYKDAAYRGKGALYFFYYFSDACYQALAYWIMSALTNDPFTLARYAGLYKALQSAGSAGSFGMDAVATPFLNEHLASWILMLVSFPLAFLVLRTVKETNYDDEQVVYVDDVKQSAAEQGAPAAEESSSIEKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K674</accession>
    <name>A0A4V2K674_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145352">
        <property type="protein sequence ID" value="TBU51253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K674"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13572" checksum="6208B2EEC19DA4F2" modified="2019-07-31" version="1">MKLSSDQNGDPLELENWIQSVQAAVKTGCTATSDIKKDVISSAISLRVFPSLLQGRATSYSALRDADASANSNAKAHESLPSWMATHLHGASVWSDQVVHQRAPQLADGSGEVALGVVNVSVEHHKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6M4</accession>
    <name>A0A4V2K6M4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145237">
        <property type="protein sequence ID" value="TBU52773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6M4"/>
    <dbReference type="STRING" id="114155.A0A4V2K6M4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="555" mass="58972" checksum="12D62BB21E93664F" modified="2019-07-31" version="1">MAPVSAATKYDTAPPQSRTSNSSGNWNRQQSYRAPQHDTTERKQLLAAPVVPPSQDRRLVQAPALNPIHPTWPVDSKLSKLQKSYGIYPSLTSDIYIYERSITSASFDDELASSPSSDSSSSDSDHFARTATYASVEVSSTRASSSTETLESTLTARAPAGTHPNAVAPLAIAAAPRPPSTRPRHDSTSAARPVIPLTRAQSQLQRSISVSRVVPPIPLASAPLENLSDSSDSDTAVSDTHIDGMVVDMLGAPLSGPSSYGYPGRNPPSFRTRRDSTDRVPSNSYRRDAPSASSRDLPAARSVAPPPHERSQRREDSPRADDQAYPRAPPGLTSGGAAGGGVATVPDGSPPRWNSDPSPSFSSNGSPTARSAGSAPALARTTSTRPGPAIPFPGPQAPARSAVAVPPSIPPAAASPTTASPPRRDTRTPSPQNTSPAGSPTTHSPTQGCPTSAIGPGALVVAPKRNVRWNDNLVCPSPVPLEQRRKGWFNRRGDQLWTNDGQYKVPAQGQEFPPDLALYPEPNTGWMNEEGVRIDMQHRLIPKQPLRPALKRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K734</accession>
    <name>A0A4V2K734_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K734"/>
    <dbReference type="STRING" id="114155.A0A4V2K734"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="804"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="921" mass="104725" checksum="926943B1AE5BF523" modified="2019-07-31" version="1">MLDAEAAIHKKPRAAGDPADLEYAILPLLLWSDATQLSSFGSASLWPIYLYFGSLSKYCRGRPTEFLAHHLAYIPGLPDALKDFYMATYGKAPSADELKFCKRELFQQIWLLLLDADFMHAYEHGIVLLCGDGVLRRIFPRIFTYSADYPEKVLIAALRPLANCLCPRCLTPKDKVVHAGTKADERWRGHKRRDTQALQAKIHRARKNLFKGFSITGKLVTSWLNAESLTPIQSAFSTRFYEHDVNFYDLLAPDLMHEFELGVWKGVFIHLMRLLAEHGEDTTEEFNSRMRRMPTFGRDQIRRFWHDTIMPAFEGLLDVSNDRTVADLLFELANWHALAKLRLHTEITLDIFRASTKNMYNAIHRFAKKTCPQYQTKELPSEVTARTQRAKAANVHAHPSSTRKLIAFKVHHTYKFHSLGDYPDYIERSGPTDNYNTQVGELEHRHVKRYYARTNKIAFELQIARKERKRSLLASIRARDSFRPLSARKQDCKRIKIATAEAHARSVHSGFTKPHHALVVLSPTEHHHIEKAQRDGFNLWFWLGKHEADAATKSFTSLLREHLAQRFVGQGAELEDGLSDEHTSGVQILNDRLYQHKTIRVNYTTYDMRREQDSINPRTHADIMLLSPESDDDAFWGPGSTRATRKWQCIDFVWVRWFERDLAYRAGFQHRRLPRLQFVDANDPENIPFGFIDPCDIIRAAYIIPAFEHGGTTDLLGPSTLARRLKDDDDEDDDWCYFYVCMWANRDIYMRHLGGGVGHRGVGVSLEHSKIHATRISRHGHARKQHFGARVGNTAEPVLLQSSDESDVVSYATQSPDPEPSQDVSTSEQEEDEDLDGDVIGGEDSGGDAESSEAEGNVYTGSDADAGESSGHESEPEEAGGTDDEGDVSDESRSRVSESEEEFDVDGSVDNVYTAEGFVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7A2</accession>
    <name>A0A4V2K7A2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_826045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7A2"/>
    <dbReference type="STRING" id="114155.A0A4V2K7A2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="515" mass="54228" checksum="9F9396E824CEF84E" modified="2019-07-31" version="1">MSMSAVAAHPAYAPSAADRRYGHELAAHAHAHYDPATFFSYSQPSLNAVTASAAALDPSYNSPSSSYPWDASFQTSSSSSLANDPAAFAPSASSGPPSLSNLGATYADYSAHRPALPARSSAHYHIPHHPQPASPASTHSSTISSPTSRSPYSSSSRGYSSLAAANASHSATSSAARLQHATWDSSCLYTIDPCDPVHTPLSPLSPLTSPPSTPIKTEDPDGGLVIEVSVPAQPVSGAMPEVPLRATHAVPEMKRMMYAFRLENFAMHDGIKSAAVQPGSGGIEVGPLKEQPVELEWQVQLDAPLVADEEEDAFRYPTAPRAQGKTAARPSTLYRQDTPVSPRQTGRGGYVSMGSASPASSLDYPSAVENDAWDASSGYGSVAGTSARSGPPSTSSPSFPSVMTPAQSLNWDYQPGEASIPPSTYRRQPQPSGQRSLSRVSQTHGQYLLSGSSSSKVVYPQASQYNGYESSGYPRHTSSSRYGGDVYAASSAGSWLVKCGVTPHTERKFFFLAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7P1</accession>
    <name>A0A4V2K7P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_599673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7P1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="34348" checksum="4EB69CB7FB43BECC" modified="2019-07-31" version="1">MITGVLSEAEAGTPSLCVVPSGLGVRALLRPTPSPLRASTCDPSRPVREREGSRDPRMDSSSITFPRSRGLWVAWSATCPLPPQLTRGTRKAHEQTMRWTSEGGGRAARLPSTSLIAPLSSHPFLAAGVATPIASSSFRAEIVVFRGAVIPSSTASSCVDPSRMDVTVASTPAINAGGDFTFMRMPAFRTLPSPDMETDVLNAVPMTLSAVWHTWLAQASGLTNSHSDVWATATQRRYSQPSSVFYAGATTRQGSPSSCALSQPTPSCTLPTNLAIPGVSPVVRSSEGTSTLARVTTATQSSISSGSQSADVRTSSCASNPVLGGACRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K902</accession>
    <name>A0A4V2K902_9APHY</name>
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        <recommendedName>
            <fullName evidence="1">SLS1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_946049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU61968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4V2K902"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048401">
        <property type="entry name" value="SLS1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20778">
        <property type="entry name" value="SLS1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLS1 C-terminal" evidence="1">
        <location>
            <begin position="16"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15726" checksum="A3A3419745725AC9" modified="2019-07-31" version="1">MPILSASRCWTGVQADVNVMMPDRPMDLQFSVDSSTNLPVSQQPAELQQYLKELEAFLNGSDSQPNQPSPPLQIRHRGVDYLLRANASVRQSEEEVADYRTSFQSIENDEVPATRAVCESILDLESNQKTMRCEVRLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K970</accession>
    <name>A0A4V2K970_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_974150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K970"/>
    <dbReference type="STRING" id="114155.A0A4V2K970"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="743"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="773" mass="84390" checksum="8C45054AC944B25D" modified="2019-07-31" version="1">MISNSFPRDRERSPTPLSQWQTKAEAAAGKGKKPIYSNRSWVRVRDSDPPSVRTRDVSGAEKPVLLARVSDAGDADTRYDHEQREGAVKDGGEGEVSQVLGEKMQDEPSAQTVTSGVRIKTEELPVTIPSPTRSEHLVRRKRGSRSTIDVFGNPTDFPSTGTHNSGTNVPKEENMSMESTRDGVIDVDAFLAAALPPQTDELYLVNSFPSMSPTTAHNTVGRPPADVIAHVGGISASVSRSTSSPAVPPLRQSPPLSQRVLDQCRAILVPLVERNAKLRKPGVDEETVKRRAYRLLSDKLCADFVKLAKQVREQISGEKATDTMHSVKRVREPGPDISVSPPKRPKLELPTEPSLEIVTPMALDEDTPMDQDTEVLPPADHAEVHVPADVTPPPSSRSRIASPSNPDPALNRDRYPDISPTDLQPHPAIPLPFPAASSSSLGSPSPTIPTSQPPAPDEPSMQVPSEMPSDNQCTIIIPATSSPFLPPHSPQTSSVSIDREDIAAMQEADNIASDSSRHDSETVTRILDRTPEDERVVQEPDDDMHSVQRPNDPPSEDYPPCVVPGLWVNVRGQPSARIESMDFFVDRATADAIQRWSTRQKSISLNERHVAVHLLCLPITPAQAVLQDPRLSPEDVAATLFDIPSDWPEPGKLVVEVKREDNTSGTAWFTHQPSPWTTHLDITLTVRHGKNTLDLIHLAPLADRLFVLHAAEPSEDEKMAAYKQTLIWLNLERARRRPKSPRSPKGVPRKPSTSPGAASSRARMSPAASVAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K974</accession>
    <name>A0A4V2K974_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_945638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K974"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="688"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="298"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="753" mass="81743" checksum="B4A539BF3C635697" modified="2019-07-31" version="1">MQRASIPQPPQNHAPFRAPAHKHAHHLHSIPPREKSTRTLIIDHLLWVHGRTRFAQARAELGMTDRTGGPSSSNYVHRDRPENFEEDEEAYSDGEDVRVLSAREGGPEHTHADDEDERLERQDLPLARSLRQRAESVEKVATAMLDQPPEVRPMHPDDLLEPPTSPSLQPQNNRQHQHRLPNGVRLRLALATVVNDFFSRRAPDPPSRAPVAPSDPNVPASAVLPSALVPLAGLSNAALLPGIPRSPRKPVPTEYIRSLYAIGSDPDTSNSPPSLRCPRHLHMGCEICVEAKSQFTVRPGQSRGRPASGRAGSTSGSSPGDVSSPGNGPVLATGVTGWQDGSGIGSGLARPGPKGTVLRRPSMPNGILVGNGQVPTMFNTKLAELIPRFMRLSALVAMELGRESTEDRTSVDGGDRREEDGVVAGSSNSGGNMMNAPPTPRPMSSPQTSPRVTAQRHASDSAFYLANAFRPSREWYYLFAGLLTRAVLEGYLTANWRGIEPLEVLLGVGLAMSHSHTRPPRPPNSTASSSSGATANRASGGDDPEFTEFDPDDLPELDEATKVLFPSLREPLGGGQGPVYYAREGAELEYELEMTERLARFYAVPSTTPDVATHMEDLAWQFPAETVERAAVRFCEAIARWRGKPELETYKQASWITGSKDQNQTSASANGAGSAGTGAMSIESLVHSNPASPTVSTLPTPVSARPSEHARRGPAIEQYFTMPPSFSLQNRKRRRDESDRGDDIRRAPPMPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9E0</accession>
    <name>A0A4V2K9E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_808814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9E0"/>
    <dbReference type="STRING" id="114155.A0A4V2K9E0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="28218" checksum="F7D000DB765B7ACA" modified="2019-07-31" version="1">MASRTILLSRLAKHVAHPAPGSTLARAAVQTAASLTTALRFPQTRASRPSHSHSHRPPVPSRPSSTRHISASAPRASNPSVAQSFADPDRPDLHYHLFTPPTQLSSEYPVFALSFLPTPPPSILSSSVIGWLPASGEGEGAGLNDFVENERFLAVLHEAIQSALRDGVDEVQKAGATQTHAGWMHIHDGRNIPALQRIGDPDDIIASVRVEDGEILAETYQPMPAYRLCTSDGVLQLTEGLAARLVEVLEARVKQEHGQGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Z2</accession>
    <name>A0A4V2K9Z2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phorbol-ester/DAG-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_803111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V2K9Z2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00029">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="4">
        <location>
            <begin position="539"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="920"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="922"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2257" mass="251397" checksum="4E9FD341726A97DC" modified="2019-07-31" version="1">MNRARNESRKLLAHILSQLQGRPVPPSLLSTLVLGSVTNEKGNGSVIKSVKGAVKYTGTLPARRTHQPLPQDDIDSDEEDVEAFSTDITLDLINQLKDVLVLSIAHSWDIFYDSNVPQTQRSNSEKIRDSFRRRSLSVGRGPRSRSPSVGRGESDGAVRAPQLLSQCISILASVIAEDCRFKITAPRPSRPPNSLQFAVLDVARFLLHTHRHDPRVISQIGFALLPAFMTFSPEMHTRLLGFLDDGVLGNLLADLRSYQGTRQLPSPSADLSYGDAPSNEPPMVSILVDEVKEDSAAAHTDSNWRRWLRALSSEDLALRSTSAPLQDIAIYHLSSIIPPLLASVLEHIDLTTANSSTLHRFHRLLSHIAESKPDAYLDALAVVAYHTPRARYAAISLLLSYWPHAIGHLTVSKPFPTINYHEAVARETSGVLVSRRHHAHPYSHQFVPWRFRVSGPSIFSGVSQNDCHSCANTIEGFGLLCPLCMCMVHFDCYDYPDGSFFTQYGVAADPSVQKVAVHKFSHVLPQRYTSGPEVVHKEQHAFRPVNLFSLTLCFVCRLPLWGPALQALKCGSCKQFVHSSCLTRATSEDLPRCRSAVIDDTYMTISWKALRQSFADHYREVFLTEADLPDRTYEELSVFLAVLWMQLQILTNGLALGSIVVKQGNKASEDKHLDEFELHYLVNLYEAYLSSRTPPVSQALSDHFAENRLRPADAHIFFNWNVLTFVISVVKSPPSSVDSSNFSSTDLLAPSMPGQDRGDDSGYPYEVVTLAHMRDQLGDQLNLHSEAAAKYLLSHLLHLGFFQRVDAQGVLFDGGPHPERLQCSFPIPIGLEVSTEVETLVASIEACLSNIDLSINEAGLLLLCRKVWPDGMLTEYALRRLSKAVLSWILAEDDDLATVLRDYVARGLSIPGVRSGVDIQPWPNTTQSRPTAASSANNGGDYVAGRRSLSSRYAARWLLALHDQDIEVYAVMVFDLLVELSQELPVADEFFLGKGRDPIEKREAAITERILHLILKLSQVSVLYTAFDDLFQKWLDRASSLDVDQQMPIASLSRLFNREFDTASQRLSALGEARLSMTENQSLMTINPLKVIVDIATKSNEGYDNTLHWLCLFVRSGIEVSVPTFMELVGLGNRFGISLEVCSLLIKAALWSCWLKSMGRQDLQTVVANIHAGIGAQLVMYLQAHHRTDEVVQVIRQSLATCLLLYGCDRTFLISAGLILESEIQGLPSRRKLHARASTVADPIIVNAAIVDALKSYVETGLQEVSCVAAKFLDAFMHHAPLVESYEVDNFILRNGSALCTCVWHFYSVQAAEISTIRTGLLLRTLVVDAQPLQTLLESLFEMRGSWEVRLQAVVQLFRIVEDVTSPAFVVEDRQWRSSVIDVFRYFFAAMWEDEREEVRLAVDTWTQTLQTAHFEAITLCWDEALAKSPIPDRTKLVSFLNQLRSHFPQWRLLSWNVLLEALLESEFIQRNGDDEDGPLSAHLSMYGLPSASRKTMLVDPDLQSLQNSLISLALRMIAEGIPIEVSQMLKLKDHLARTLGFAEVSMITIGTTNHFFVQFGSLDVIPEEAYPCLNELMLTLDSAQPYSLVSSSMGGRYSDDETGAAVLVGSIFVDLFLETFIQCENLEALPPLTLKNLLKSLIIVIYKHDFDTRPLKLFQPQLRRAVKRALDLLLEELSYDLRQLVLTACHAFIKRWPHLIGNFVCDAIESTISLMEKTNYHQHGDDILIEQTKSFLRTVLGLYAFSGVFYLLCKRRRTPEFFAIIKSITGPTVRAEHNPHPHETLRDAILRDTLTRAVEGDDEALQIVIDNVNTYVEVVHHTDYSLSLMQFVGLSLANLTRKTADIHHGRFDPSPLLLLACNLIQHNKANSRDLLLYLETLLRSSLIRFNVSVASLRRVLHVTTTLYRRAAAKAGQATPQKALVNPITSAMFEITRDSLNVKARVTHATLTALVEALTLTPDRGSAKVAFIPLESQLTLAHDGLAYLYHESTSDGLIHSDFITSQAVAKMIMQGAEVQPSLLTNLAKNPITVRVWNILSLAALSRSSGASAALLFEHFSTFTLAYTTSLLPYQTVHMLDSPEAQDRAHADISTAYASIKLWLLLARKAASGHPSHDASGTLQDGEGLAAKMVWNELWPPFEMVVVAFETDSRSGNVSPVASSIWTSVGDLFLFVRQSRSVIALDTAVPARILERLKGVVRGDVGKVLRVVRSLKDAPPDDSLDYFVGQLLTEITAEEKLQAAKRQINMDRGRRVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2KA13</accession>
    <name>A0A4V2KA13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_803778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2KA13"/>
    <dbReference type="STRING" id="114155.A0A4V2KA13"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="66"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26037" checksum="40868B4B7ACB1D68" modified="2019-07-31" version="1">MANPRQRRKTRSGSHKPVQHSKRAKKLQKKQPPIRGPQVLQEAWDARKTVRQNYEALGLVASLNPIASGGTERAQAKRADDKEAPARLEAPSSTSTRPAGTNGVPKGFGKIIRDAEGNVVDVQLAVDEEVDEAATEGEGVDEGVPDTRGNAQLAGWVEVGSDPKKAQGPPSTAGTRQLSEARAGPVPRHTSKGEHATLQRLIAKHGEDVEAMARDVKLNVDQRTAGELKRAIRKAGGSAALGRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MW40</accession>
    <name>A0A4V6MW40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_118364</name>
        <name evidence="1" type="ORF">BD311DRAFT_746276</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MW40"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU34503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21133" checksum="FA4390020F1FC371" modified="2019-07-31" version="1">MAAPADKTTRDISGKYIMDKSLSDDNDEILRLQGVSWWTRKAISVATLYLDVKHFTEDGVEHIEIVQTLSGVKGTTENRILDGEERPHEDHVFGAVLSTSRRVTLDEIEYDHLKKDWSDDSFADGKIIYTQAKSDTSKSGKTWTAEQVWGFEQVNGEKRYTRHVHFVGPGGEIIEIRLVYQYTGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWM2</accession>
    <name>A0A4V6MWM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_889017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145240">
        <property type="protein sequence ID" value="TBU52703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWM2"/>
    <dbReference type="STRING" id="114155.A0A4V6MWM2"/>
    <dbReference type="OMA" id="HFLQIAY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052094">
        <property type="entry name" value="Pre-mRNA-splicing_ERAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44313:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="275"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="83"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="370" mass="41441" checksum="713DC74AD502EA0A" modified="2019-07-31" version="1">MSSDEDVNPYELLGLSIEATDQEIKTAYRQRSLKVHPDRNRGNPDAARKFHELVQAQELLLDPLRRMALDAKLRIKEARKARYATYDAKRKVLVEELEESERAFKRARVEKEAEKQERYRENERIMEEGRRLREEREKELTRKEREREAFERKAQQAADAILEPPPSGPLDTTVRVKYTLSAHPTLTDASALGALLAAHGAVDEPSIVLSLKPAPPKKPKRGTALVPFKQIRGAFAAVCASGRPEYRLEDIEISWAEGKEPELIGWLKKMGQLGKATNGAGKGKGKDKLAPHQDNNPVASTAATPPPPSNGTFSSFPSTFPDINAAPPRPSAPTAVPGLDYESLTLMRMRQAERERLEREIREQEADEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MA75</accession>
    <name>A0A4Q9MA75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_815619</name>
        <name evidence="8" type="ORF">BD311DRAFT_781714</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143506">
        <property type="protein sequence ID" value="TBU23387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MA75"/>
    <dbReference type="OMA" id="YTICETP"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="3"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU23387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="433" mass="47807" checksum="A47D2C047E33A79A" modified="2019-07-31" version="1">MRILPAGMIIHLLSFIDRSNIGNAKVLDREQGDSLVQTLQISNEQYLLALMIFIVAFTIIQTPSNYMLKKCGPSRWMALMMFCWGAMTMLLAAVKNFSGLVAVRFFLGAFESGLFPGLVYVITFWYRPEERAVRIALIVACSSLGGAFGGAIAFGIGKHLNMVRGLEAWRWLFLIEGAPSCLAAILCALFFPDYPETEAWLSDGERELATQRIKGVASLGHEKITWPETKATLMDWRLYGHYIAYISNSVSFSSNSLFAPTIVAGLGYTGLDAQLFTVPPYAIGFVVTVLVSWIADRYEVRSLATFFSMLLAGVSYVVQGALPPDAFVTRYVFLCIALSFSFACNPTSMSWLTANLRSTGAATLAIPLCVAFGQLGQIIGVYIYKDSEAPGFPTGHFTNAGFLIEGAILIMSLRLFYVYKNKRLASGERQWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MD49</accession>
    <name>A0A4Q9MD49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chitin-binding type-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_976792</name>
        <name evidence="4" type="ORF">BD311DRAFT_767899</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143496">
        <property type="protein sequence ID" value="TBU23736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MD49"/>
    <dbReference type="STRING" id="114155.A0A4Q9MD49"/>
    <dbReference type="OrthoDB" id="2142040at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12214">
        <property type="entry name" value="ChiA1_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.20">
        <property type="entry name" value="Carbohydrate-binding module superfamily 5/12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003610">
        <property type="entry name" value="CBM5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036573">
        <property type="entry name" value="CBM_sf_5/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006616">
        <property type="entry name" value="DM9_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649">
        <property type="entry name" value="AGAP009604-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31649:SF1">
        <property type="entry name" value="FARNESOIC ACID O-METHYL TRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02839">
        <property type="entry name" value="CBM_5_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11901">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00696">
        <property type="entry name" value="DM9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51055">
        <property type="entry name" value="Carbohydrate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chitin-binding type-3" evidence="3">
        <location>
            <begin position="4"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU23736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="314" mass="35253" checksum="2180250D5E755134" modified="2019-07-31" version="1">MTYEWEPGTYYGEGSVVEYQGHKYKIIQPHTSQGDWTPPATPALWGRLPEDYHHEEHHEEHRQESGYNPSYNQDGGSSNEKHETVIIHEEERKTGWDALSDERKHQIEVGGGLVAGALALGAGFFAWNEHKKSEEEKKQHMWDLSNWLRDAEIRTRDFYGGRVSSPVTWVLVEGKNIPTDIAIVGGEEHGTPHYICRGWHEGSLQIGKASSIFQKGGVVGYAHSEHHLGKFEVLVGDKRAVRWVDFHGRCELDKLPGRPVEGGREADGSPLFIAKGVYNKAIVPGKCGPKLPAAFVPYANSEKEVKDYSILCYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MGM7</accession>
    <name>A0A4Q9MGM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_579622</name>
        <name evidence="1" type="ORF">BD311DRAFT_489232</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143456">
        <property type="protein sequence ID" value="TBU25728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MGM7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU25728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16879" checksum="53F369F2E8EF9DA9" modified="2019-07-31" version="1">MNSHRISNAEYPYVLQRRATRHSNKSRAMQTSSFPASHLGIHTCHVTDLRSSSALDAYGAEATSVSARGASTRLIVPICLLPRGFLELYLAPANPNSSFSRHMFTHAPYPAVFLRASGGERSGLGRIAGSGAEYVHARELTTPCGHLSHRPSYFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MR79</accession>
    <name>A0A4Q9MR79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_805772</name>
        <name evidence="2" type="ORF">BD310DRAFT_816343</name>
        <name evidence="1" type="ORF">BD311DRAFT_660650</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143411">
        <property type="protein sequence ID" value="TBU29707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MR79"/>
    <dbReference type="OrthoDB" id="2499463at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU29707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6286" checksum="BBE94D1D06B1DEC3" modified="2019-07-31" version="1" fragment="single">AREAAKASRGYNSEATQQRLEETFRQRMGGKVPHQWQADVSEALLVGLDWVREDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N0Q6</accession>
    <name>A0A4Q9N0Q6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Complex III subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_865499</name>
        <name evidence="10" type="ORF">BD311DRAFT_750622</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N0Q6"/>
    <dbReference type="STRING" id="114155.A0A4Q9N0Q6"/>
    <dbReference type="OMA" id="PLAQWYT"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU32236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU66109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="129" mass="15283" checksum="B5F919FBD91941FD" modified="2019-07-31" version="1">MTIFGPLGPSLAPAIRRNRGIYAWVKPIADWYANAAGYRKVGLKYDDLLVEERDDVQRALGRLTHREAYDRAYRFKRASHASVLHDVLPKSEWTKPEEDVRYLKPHVQDVEQENLERWKWDHVEVQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9M8</accession>
    <name>A0A4Q9N9M8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_821165</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9M8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="204"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU57633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="327" mass="35068" checksum="36D4B708BB67CD8A" modified="2019-07-31" version="1">MATSCWFTFLAALSVISIGVRAVPAPRTLTARQNAVTPLPSAEIVAFKPYTWYASTAYCEPSSTKAWNCGENCNANPTFKPVESGGVVNETQNWYVGYDPTLNEVIVGLSPGDLPFIIDLEVILVPLDAELFPGVDPNVLVHAGFAATQNRHVPPWLSAPGVIAAVKEALSLYPTENVTVVGHSLGEFSLAVIAVLCPHLPLGTGAATALLHAVYLPLHLPSDVNVRYIGYASPRVGNQAWANYVDSLHISTTRINNKEDPVPVLPPIEVFGYHHASGEVRIRDDDIWVSCPGQDNPSDQCSTGAVNFLNSNATQHPGPYDGVTMQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9U0</accession>
    <name>A0A4Q9N9U0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_836678</name>
        <name evidence="9" type="ORF">BD311DRAFT_744648</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9U0"/>
    <dbReference type="STRING" id="114155.A0A4Q9N9U0"/>
    <dbReference type="OMA" id="DFAIEFC"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="7">
        <location>
            <begin position="13"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU35806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="463" mass="51875" checksum="AE87CBBAAAD764DA" modified="2019-07-31" version="1">MSNLPTKQKLWGGRFTGKTDPLMHEFNQSLRYDKRMHAADIAGSIAYAKGLARVGILTQDEQQKIVNGLTAVGKEWEQGTFEAQPDDEDIHTANERRLTELIGPLGGKLHTGRSRNDQVATDMRLWLLGEVRTVEKGLKDLIRVMVERADKEQDILMPGYTHLQRGQPIRWSHLLLSHAFSFRADLERLQQLIPRISVLPLGSGALAGNPFAVDREFLAKELGFDSVAENSMYGVSDRDFIAEFMMWASLAMTHVSRMAEDLIIYSTAEFGFITLSDAYSTGSSIMPQKKNPDSLELLRGKSGRVFGNMSGFLMTYKGLPSTYNKDLQEDKEPLFDVVDTVAASFQIAEGVIATMEVHGDKMFKALTMDVLATDLADYLVRKGIPFRETHHVSGRAVALAEARQCQLNELTLQDFRSLHEKFDEDVLAVFDFEASVERRQSIGGPSRKMLERQISVLRSAIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NG03</accession>
    <name>A0A4Q9NG03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trm112p-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_942419</name>
        <name evidence="3" type="ORF">BD311DRAFT_761577</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with TRM9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143439">
        <property type="protein sequence ID" value="TBU26938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145346">
        <property type="protein sequence ID" value="TBU51284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NG03"/>
    <dbReference type="STRING" id="114155.A0A4Q9NG03"/>
    <dbReference type="OMA" id="NMLTSKC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21089">
        <property type="entry name" value="Trm112-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000018">
        <property type="entry name" value="Multifunctional methyltransferase subunit TRM112-like B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00065633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU26938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13784" checksum="729C2839A03678F3" modified="2019-07-31" version="1">MVRLITHNLLACHAKGCTSNNFPLQFQDVSIELRDADFNADFLRGFLPRLEWPALVGAARQLGDTSLPAEQPDMIDDEFLQKLHHVLLEIHVEEGAMVCPNCKHVYPISNGIPNMLLAEHEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHG3</accession>
    <name>A0A4Q9NHG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD310DRAFT_923546</name>
        <name evidence="20" type="ORF">BD311DRAFT_727811</name>
    </gene>
    <organism evidence="20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 464.89</strain>
            <strain evidence="20">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 14">Cytoplasmic vesicle</location>
            <location evidence="1 14">COPII-coated vesicle membrane</location>
            <topology evidence="1 14">Peripheral membrane protein</topology>
            <orientation evidence="1 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 14">Endoplasmic reticulum membrane</location>
            <topology evidence="2 14">Peripheral membrane protein</topology>
            <orientation evidence="2 14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Golgi apparatus membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143461">
        <property type="protein sequence ID" value="TBU25469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHG3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHG3"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01478">
        <property type="entry name" value="Sec23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000006">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="11 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="53"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="121"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="396"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="511"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="623"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU25469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU60204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="763" mass="84774" checksum="E2A9B47A148C3894" modified="2019-07-31" version="1">MNFEDVEERDGVRLSWNVWPSSRIEATRTVVPISALYTPIKVREDLPEILYEPITCKPPCRAVLNPYCQIDIRGKLWICPFCLQRNAFPPHYKDISNTNLPSELLPKFTTIEYTLSRGATVPPIFLFVVDTCLDEEDLKALRDALVVSLSLIPPYALVGLITFGTMTQVHELGYAECSKSYVFRGGKEYSPKQIQDMLGLSSQNRAAPRPGQPLPAQNFGAARFLMPAQQCEFQLTGILESLSRDPWPVANDKRPLRCTGVAVSVAVGLLETTFPNTGARIMVFSGGPATEGPGLVVSNELKEPIRSHHDIDRDSAKHFKRASKFYEGLAKRASNNGHVIDLFAGCLDQVGLLEMKSMPNSTNGVIVLSDSFATSIFKQSFLRMFNKDAGGFLEMGFNATFDVQTTKELKVSGMIGHGISAAKKSPCVGETEIGIGQTSAWKINSVDPRTAAAVYFEVVTPAGQPLQPGSRGLIQFVTHYQHSSGKYRLRVTTIARNFAEAGSPSIAASFDQEAAAVLMARIAVFKAEIDDSPDVLRWLDRMLIRLCQKFADYRKEDPTSFRLTDNFSIYPQFMFHLRRSQFLQVFNNSPDETAFYRHVLNEEDVNNSLIMIQPTLMSYTFDVPPQPVLLDSVSIKPDVILLLDTFFHILIFHGETIAQWRKAGYQDQEGYENFKELLEAPVADAQDLLADRFPIPRYIVCDQGGSQARFLLSKLNPSTTHMSASMYGTPAGAGAGQAIFTDDVSLQVFMEHLKRLAVGAQTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHM9</accession>
    <name>A0A4Q9NHM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_868415</name>
        <name evidence="10" type="ORF">BD311DRAFT_687587</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6 7">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; iron-sulfur cluster biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHM9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHM9"/>
    <dbReference type="OMA" id="SMVTEMV"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="UniPathway" id="UPA00266"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000008">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU32010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="185" mass="19901" checksum="70DB4AAF861E5DC8" modified="2019-07-31" version="1">MLRSSITKSLVNVTPRASRLAVRPALARGYHEKVISHYEKPRNVGSLPKNDVDVGTGLVGAPACGDVMKLQIRVDENGIISDVKFKTFGCGSAIASSSYMTERVKGLSLEEAEKIKNTEIAKELCLPPVKLHCSMLAEDAIRSAIRDYRTKRSKLGDPKKPGFIDVSQSAATGHTVATAHPPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIS0</accession>
    <name>A0A4Q9NIS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_830433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIS0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIS0"/>
    <dbReference type="OMA" id="PMGQHHI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="276" mass="29481" checksum="D9E35C24FB8749C7" modified="2019-07-31" version="1">MPLNTTVSHVSPLLSYIPRTSWYEGNSSDPELNRYSNQSYHYSDSPASVTFSWWGTGAVFGGYRNRTGAYQVVVDSQAATSFPGYTGGPDEFERVLYANDGLSYGQHQIRITNTGGGGPQSVLDIDYLVYETTQDDGGEIQHNDPGCSWSPASPNTWQVDAASHTTTDTFGAMELNFTVSSGIILYGYLDGTSAPLTVSVDGWASTPVAPNTAIAPIVHNVPQVLYTKSGLQNGPHTLRVENNPLGINGTGSKMSIAFSRTLSDAPAGSAPQQETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTK9</accession>
    <name>A0A4Q9NTK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_817261</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTK9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="742"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="887"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="95"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="758"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="891"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="938" mass="103588" checksum="7F76C6A1EE7164E6" modified="2019-07-31" version="1">MPADTSKPNALAAAARRRNNLRRDTEDIKYDSSHAREIELKRSRGEISCAECRRLKIRCDKTIPCQSCQRRGCAALCPNGTLATGQGTRFVLAATEHLHRRIAKMSERIHQLEDALAILQAKSSNEPHPLLSDGLSKNKNIDSDDDMLAPEQPTAASGDVVSAFGMLSMSDHGVSRFFGPTGGTEVSCLQSDSDVPSSPSNGSRSPESLRGSKTPPLPGEITRFSNAFPFTPMGPPHHVYELIEGHLPPYPRACELLESYVSHAAWLFRSVPRTQLFDEMLPRYYRQAADDDAPLPRMEQSNPHDLALLLLCFAIGALMDLKQQPYNSEAEHYCQLAQAAMCLHPVLANPTLVTIQALHLQSIYVAMVGNEPGGQDNQMEFSWALVTLAGQLSHTVGVRDRDSARFGFSPEIVERRRVTFWDLFVADAWQQSLMTGRPPVIQREYIDCKFPTPTATPDDEDLGEELETWGFRFALNCVAEVASKTLTAEAPSYDTIMELDRKVREFPIPPDAAAMLEDLDTPLDSEPPPLQDSMIRFVLSHSREVILLFLHRSFFAQAIIDCPRNPLRSAYAHSFLAAYRSSSTVLKVVRDQFKLYPSMCARFWVIWTFAFSAAVVFATVVTRGPRSAMAPQALAQLDQAYELFTQASKHSRRAAKALPILLRLREKAHCSFAAALNDPMYDGALWTVKTEKDEDELDIFAGRTAVVASKRPSPSPTAHLPPLHTGESLPLITPPSSIPIVPMADPNGVPLTEAWPTHRQTSASSSGLPHVSSQYPPQPSQQVHQAMHVQSHPHASQHPYHRLSFSQSAPPPPSPQAGSSSYQWAGGHGHSHSPSGLAPPTQSYGDQIPPTTHAPPQHPHSHYSSQYPPSTEMSADILQRYAEAGYQNPPHHAHQQHGHPHGGQPFAPPSELVNLGLASRHGRLDERWTSFMHENGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3G2</accession>
    <name>A0A4Q9P3G2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3G2"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3G2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="36747" checksum="CB4D4A1B85C37946" modified="2019-07-31" version="1">MFQSGLPTYSEIQAHYRARAELKQNFATLINDQRDIQELFKTVAAELDATPEVGEKHALSDEWNRLRRRHSKIYRESQQNAALCAQFLKNFAEILVPLSQSEDLTIDQKKLMIGKFLETIPVHLNAAHANAESFSELAKDVEVFPRKVASALRIKAEPPGLLASIWTGIEEVCYNVWQTLNRLLTKLVYTFKVALARLEKLRFSCFGISVDMHFNRYESLEPAPLSQNESEEERRERIASEVQDNCDALQHKLTAFESAWYIVRLACSRLSSDLALAKTFTTCYPPVPQAVDTNLRAAALVHTPLVDCLNAYSTGQLPDFRDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5S5</accession>
    <name>A0A4Q9P5S5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1035296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5S5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P5S5"/>
    <dbReference type="OMA" id="PLCKHHY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="6">
        <location>
            <begin position="48"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="5">
        <location>
            <begin position="171"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="883" mass="98656" checksum="A08BDA98E414693F" modified="2019-07-31" version="1">MLPALEPSVQDHLRLEAFEGKFDVKEFVGGISEKLIAQSKADPGPFDPKPFIRTFEAAVDKLIAVRKDVQAKTEQMEKSVRIAERDYSKKMAELNRGFEAVGQSFSGMETKMNEVGRTAIRIGEQMESVHQQRQRAQAAYDLIDFYNQFAKDDTSRLDAMKKEGKDGRRKVAVLLRRLATVAKEVDLPHSEKTRENIDRYCEKFEKDILHLFDRAYRRGDPKMMHHCAQTLLDFNGGTSCVQVYVNQHDFFINRVRADPNIDSQLWVAIADPDAPPPTSERGLQELFQEIRTTVGQEAQIVQAVFPNPAYVMQVFLQRVFAQSVQQHLEQLIVRTDRMPELAFLRILQLVHQSTSVLVEDMKAYELPSVIPKSPVDASEFQRTIKGMPATNASNTATAATISTMLETAMEELFVPYTEGQRYLEKESRSLSELYTGYLARFTRYHERVDTKGKSSVFGRMVDQLSAAAATTSPSGTSTTSAQAAAALMRIGGLSASTDKTQRDSTEDPIREEDGLLSVDVAEKMLKWHAEAIGRCVELSPTNDVPKHTFALLRVLAAAIGSSYIEVAVETVLARLETADSKVEPSLQPLTVLREVDLICHLWQRYVTMALLPLASSSVTTRREMVIFNNQAVSRIEGGANAVTQKLTDAIVNWLSTQLAKQKRTDFKPKNDDISFARVNTEPCLACCDMLEKVRDAAKANLSGKNLEVFLTEVGVAFHGLLLDHLKKFPVSATGGLMLAKDLKSYQDVIDSFSIPSLHERFEFIRQLGNVFLVKPDILKSYITEGYLGRIDANLLRPYLAQRADWGQAEKGFNDPTDGPADGKVMRDRFGMGRLSMIMKDLEPLREQIAIPSMPMTGISQFTGNITSSFANARSSRFSNSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6B5</accession>
    <name>A0A4Q9P6B5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_844640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6B5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6B5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="318" mass="34878" checksum="D26E036282B42421" modified="2019-07-31" version="1">MPKGGKKTSLKAALSSQQSRLKKKQEAARAAQHAERAKSGPQSKGKGKATAPSQARPTIPFGPTDSILLVGEGNFSFARALVISPPESLQYLPPSNVTATAYDTEEECCSKYPDAAEIIRALREKGVELLFSVDATKLDKCPPLRGRKFGRIVWNFPHAGKGITDQDRNILSNQVLLLGFLRSAAPFLASGPIPVVHKPRKQKRGSDDEDSGDDQENADTSNIDTARKARGTILVTLRNVVPYTLWDLPRLAKTPPPSTSTSTGQKSNPKYIQLRSFVFHRSIWTGYEHRMTKGERAHGQGKTGEGGEDRTWEFCLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8S8</accession>
    <name>A0A4Q9P8S8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_915195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8S8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P8S8"/>
    <dbReference type="OMA" id="RISHRTE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="254" mass="28418" checksum="A6C5F7CF2EA80F0B" modified="2019-07-31" version="1">MDKFVTAKKPTTVRPNGKQEPANKTERQKYRYNPYGVSRSSERKFEDWKDKKRTEKILAPLLKEGESAAQAKPSSRALTKHVLNTLKDESNPITHSNIYLRTDHICSAATGHQRSDGRGPRKSYMEVRRDKLAKQLPETSTEVLRNVRVYINGYLDNTTDIEMKRIVTLAGGQVMHTAPGATHILTSQQLSGAKTHKLLTTKSKGIVHVVRPEWVTDSIDAGKRLSEKDYAVIKVTNSLKITDMFGAGSSGTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9H1</accession>
    <name>A0A4Q9P9H1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1007571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145345">
        <property type="protein sequence ID" value="TBU51289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9H1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="25708" checksum="D08C2BC9EF82D45A" modified="2019-07-31" version="1" fragment="single">MAIDGNRWQKLQIVGKREGSHWGSTSTSSSCKPLISSSSRMTVPDFEVLLRCETWASCPLTPWSVARDPSFPSRTYFQLVFVELRPCEPAREGVRETDEGRELEDRGVEMGDQSNVEQPLGTAVSAGSWNIPGTSILEFHGEFSSIPKSKCTAKRDVLEDQSPSADNLPAWIKPAWPQIQLVAKFMPDQLRHSFDHEKIKEIEKIKQFMHPPFRSPVLYELYITSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBS1</accession>
    <name>A0A4Q9PBS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_767785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145273">
        <property type="protein sequence ID" value="TBU51978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBS1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8102" checksum="91E919DB02761907" modified="2019-07-31" version="1" fragment="single">MRNNVSNNLAMSGLPWIPEDVPCPQGVGQRTMAGLWGGAELIPWFGADEEEEDELAWLQGEAVAEEDEGEGGDGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCZ4</accession>
    <name>A0A4Q9PCZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1010839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145396">
        <property type="protein sequence ID" value="TBU51107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27123" checksum="8C6226A2B0B99131" modified="2019-07-31" version="1">MILVVAWVLARAPRVPPEQAREEFEPPAAQFEGDFFDTCADYTAADFPGFGDGDSVNAPLNAGPFPDVTEVSDNEEDGDEEVVGLDTLFPAPPQSPPLAPSRPPEPMHVDTPPTPARSQSHSKPPSPTVEYLPEDEEDPQAHAGPGGVEPNSHERLCEAPANICYFRGKAGAPVSEPRVRTSGYWKYGERVCGSQENMFAPFALETDWAVGRWANMHDISSSALTELLTIKGVSLHPISHGSHLMSLTSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDA4</accession>
    <name>A0A4Q9PDA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_786750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145449">
        <property type="protein sequence ID" value="TBU51012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="315" mass="34330" checksum="CA604B5819EF6DE6" modified="2019-07-31" version="1" fragment="single">MTGSEDTSSATSPPATPSGNKPVSSPSSARSNPPISLVQIPSWVYGRLSTLERLSIAKCNWPEWSRRILNVLCLCGGSPPLKSYVDGTVSCPDIDVFPLDHANWMQTNSLVIALVEDYVEDADLYLIASSSSARALWLALQTRHVKRGAYAQLMTIQELFRDDLDPGNTTNDIENQARRTAAEVSRMFQMGPLSEDTFTVVVLLHKMKAKMRPLMNQIVNDQSTSSTPLTADRVLDRIKHEAMQIRVDRSQGLAPPSIALAASSSHLSARVCSNCKRKGHLADRCWQPGGGAEGQRDQYLARRATGAAPKPDGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDP7</accession>
    <name>A0A4Q9PDP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_953395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145372">
        <property type="protein sequence ID" value="TBU51172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDP7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="17170" checksum="6E3E0F57B3D5B0AC" modified="2019-07-31" version="1">MSASPHLPWEVIERIIGHSGDYWRTLRSLSLTCKQLRPYSLCLMVADVTFSRSEKIFAFRDFLCTQPQFRPFVRSIGMGDPTYLAFHLLYLLPNVTRMTMLDYSIRRGSPPRVCSLPRSVLACYRTMGTRIETLILVRLSFPNPQEFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDS2</accession>
    <name>A0A4Q9PDS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_910210</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="ML145260">
        <property type="protein sequence ID" value="TBU52235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDS2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="50"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="332"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="262"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="269"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU52235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="455" mass="52660" checksum="9FEC7DF8BCF66FCC" modified="2019-07-31" version="1">MSASASAWTADANEALSLSLVRAPEDKASLWSREVYEGFHPTFTYPIFGEEEKVYGYKDLAIELKFASGSLAQYLNVQYSERLPASSAVDEIEDTLAKFIPEGYYTDEKRFLERVEHDAANFKPFGEKIYSYSRTAMPVSKGKNVAIPQVLSPEDQETVDYEVYHASIWAPIRRPGVAHFKSTWKTPGFREFHRRMQLFVLLYIEGGSYISEDEETWEFVVLYEKRRRRSSPDVATYHFVGYSTLFPFYCFPERVRLRISQFLILPPYQQDGHGSALYTAIYQHVLAQPRIAELTVEDPAEAFEDLRDRNDLKMLLANEKFMREGFGPEAVSSNGGKVGGVGNGRTRRGVKHRTMRAGAGKMGPPAERTWLEKWRTELKIAGRQFHRLIEMLILKHMDPADERGNRAYRLQVKERLYRFNFEILMQLDKQERQQKLEETFQSVVADYKRILGHVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEQ0</accession>
    <name>A0A4Q9PEQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1003631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145291">
        <property type="protein sequence ID" value="TBU51717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="296" mass="31780" checksum="7461FAA1641384B7" modified="2019-07-31" version="1">MSQSGTTSTDPVFIFDSMITTAEELRCFWGRKITGAAILFWLNKYMTMLCLVWDLATGLSISDKSCDLSVRGDAAVDYLLFIVLAAFTAIRVYALRRSLTLCAITAVLSLVPLGINMAYFGFGMTGENIFPFGCTEMDDEPTSLSHILIAADGLAIGATWFTLGLPNSVGQGVKADSIIYVGTIYFLTLAVLNSLHLAFTLLSVDIDAVQPVSVVANFTTPLSAILVSRLLLHLQSASLRAVGSIPSSHISSLHLNRSLVFERVVGSLGASIVAEDYLKEDYGGGDDGERADEEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFH8</accession>
    <name>A0A4Q9PFH8_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_941778</name>
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    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145293">
        <property type="protein sequence ID" value="TBU51691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFH8"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="80"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="303" mass="32454" checksum="60BC67B8AA3DE207" modified="2019-07-31" version="1">MHLQPHYQHFPPPQQRHGGAMLDAAQQRLIHGLDRQQWQFWPVGANNNDAIQARHFAGRMRPVRGGMGEPMQIHGVGRGGGVGGPMHAAQPVAGPSNAPAPAPAPAAAPPNPDGSPSPAPSEDKEDLIVHPASVIGLLRECGYADPTLFFPLFYALSRTTWQFGGAALGHHLAPLAAADMERLVVGIERVRAHHAAFAVAVPTLDPLPHHQGMDGAHARLRCLTGASQLWATMVPKLLLGTNDASVIPPGREPLEEWAGVVPNVAGQCARHGVCADCGRAIVARIEAFRREFWAKLPQFFELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG37</accession>
    <name>A0A4Q9PG37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_791659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145270">
        <property type="protein sequence ID" value="TBU52032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG37"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7945" checksum="EA8A4C4346953EFC" modified="2019-07-31" version="1" fragment="single">MTNDNASNNYTSAKAVAKRLKKRGIGADWNALERNLGCYGHIVQLGVEDFMGAITQKAVAETKQAIWEYDPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG92</accession>
    <name>A0A4Q9PG92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145216">
        <property type="protein sequence ID" value="TBU53355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9322" checksum="DE678280F7F90BC2" modified="2019-07-31" version="1">MLLNIQGVWGLRVYLLDARNVLALRFRRAHSRCRRETRPWRPTARYLGTRASRGAWVGACVAHRRWAERGGSSRAPCVDCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGL6</accession>
    <name>A0A4Q9PGL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_829699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145209">
        <property type="protein sequence ID" value="TBU53625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGL6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="533" mass="57111" checksum="37404C7F59B6EBF9" modified="2019-07-31" version="1">MEDIPRPFSPEYVPQPLNPSPFHTRFTNPQRVPTPAVLPERSGSHLYLSTVSQPVQEPIHIIHDFYNVSPIAFHFAPNGSLPRTVELPLISEAETRPTHALAILSSTIPSSSNKPYTSLRLDTFPSAPPSASLLDRPRDHQPYLIPIDASTFFLNFGHDVARSLGALLTSRPAKSQSPPIRRDRENGTRFVTLPVIPLHVPHPPSLPHVLLFGQGIPLPRTPSPPAQSDPPSSPRSASDSGRIASPSMLATYLLPVSAIEEFPSSPAMAAIMAWQCSSEELATRVAFNHGIWRNTLLLAPTDAALEDLVRIAWNVTIEAQRLQRQGDAASARSLSPSLAPSLTPAARRPTPVVVTSTTDHGPTKDADRDGGRNSVTSPRPSAFPTINKPASTAHGAGENAKAIPELIVPELMQNVSSEAEEERPRVAKRTSLPRTVPVAAVSYSVHNPAARPPVDGSYIAVSSPTCGARSSHAATPKTAARLPVVEVDYPVAFDTPLSKARCAFAHHLSGGDNALMAPLSALKSSSGRRGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGS2</accession>
    <name>A0A4Q9PGS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_941616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145286">
        <property type="protein sequence ID" value="TBU51776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17004" checksum="FF0A6D17B57C5610" modified="2019-07-31" version="1">MQLAKSFQRCDRRLPLPLPCAHFRHHPLPILPYPLLCSHARHSPPVCDTGPLSQPRAEAAPPALNPSARSVLGRASDDVLRSAKLVSLKGFLSQADDRCGTQPLSRRSQISARVASRYSRSSREGARGRLCARGHEGVPSGDRQARAGGKDDETAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGS9</accession>
    <name>A0A4Q9PGS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_314581</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145285">
        <property type="protein sequence ID" value="TBU51786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGS9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13575" checksum="CC85F657A61912F4" modified="2019-07-31" version="1">MYYDRLARKVDTMLTRNTKTATFRSTPRSPDYPCSLCKPSTCPLQAHLVALQGASRYELRHLKATLTSLRGNTRPKSATRVVLNAIFHGIGSGPSQHCMGRRITLLDSFENILNGIRKENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH72</accession>
    <name>A0A4Q9PH72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_939510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145238">
        <property type="protein sequence ID" value="TBU52751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH72"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="174" mass="18336" checksum="2C2CF85D0FDEF8F3" modified="2019-07-31" version="1">MASTQTQTWQPDVKSHEGPIDPAVLPEYTLLPTSPPRSVVSYNDPDGASEAGSSASNHNADATTCGTESLNIIKMFYTGILAIVFPPMIIGGAALAAAGVMLYGCGRVLEGIGRGLSIGPEVVFRTFMRKRVKMLRGALREGRRVPEQEQGQVVEGQVALEDVEAGQVGGPIAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH81</accession>
    <name>A0A4Q9PH81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_952507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145237">
        <property type="protein sequence ID" value="TBU52771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH81"/>
    <dbReference type="STRING" id="114155.A0A4Q9PH81"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="358" mass="40029" checksum="5FD3CF7B7BD8ADE0" modified="2019-07-31" version="1">MPFGEVVCGSPGSGKSTYCYGKHQLFTALSRPIAIVNLDPANENIPYPCAIDIGSLIRLEDVMNEFGLGPNGGMLYCMEYLEANYDWLEDRLKELDKDDYVLFDLPGQVELSTNHPSVKNIIRRLMKSGFRLAAVHLCDAHYVTDASKYVSVLMLSLRAMLHLELPHINVLSKIDLIQQYGDLDFNLDFYTEVQDLSYLENLLSQQSPRYAALNMAICSLIEDFGLVGFETLAVEDKESMLHLTRIIDKATGCVFVPPPTVGQPPDTIDASSKPASERPNTYALMTAAAGPIRGPRADVRDVQERWIDAKDEWDAWERKQWRREGELVQEEEARRKSGKIRERTPKAAQGGGGSSLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH84</accession>
    <name>A0A4Q9PH84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145237">
        <property type="protein sequence ID" value="TBU52781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH84"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9614" checksum="BAF1296358A27684" modified="2019-07-31" version="1">MSTTVCQHATPHGGAALAIVAFLSTLLQTTCLLVTNLGAARAPKSANDSQSPYSFRKYVAQVLCLTPMHRHRTVLRRVVPWAVVSTPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHC0</accession>
    <name>A0A4Q9PHC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_831262</name>
        <name evidence="6" type="ORF">BD311DRAFT_677601</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143579">
        <property type="protein sequence ID" value="TBU21747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHC0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHC0"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000008">
        <property type="entry name" value="Proteasome subunit beta type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU21747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21801" checksum="7ADDD9F14F59CFC0" modified="2019-07-31" version="1">MDISFALTGKGYVIVAADTVAARSIVKMKVDEDKIKVLSPHLLMAYSGEPGDTVQFAEYVERNIRLYQIRNTHALRPPSAASWIRRTLADSLRSRKPYAVNLLVGGYDTSTHNPHLYWIDYLGTMSEVPFAAHGYGAYFALSLLDRYHDPEASVEEGLATLKRCIDEVAKRLVVNPEKYKVKIVDKDGVREVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHL5</accession>
    <name>A0A4Q9PHL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_998031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145251">
        <property type="protein sequence ID" value="TBU52436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHL5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="301" mass="32206" checksum="99401E344D6281C0" modified="2019-07-31" version="1" fragment="single">AVVFLYDTMITTGEEIRSFWGRKITGAAILFWLNKYMTVLFWSVNLQFNKCCPCSCALLLRGVAAIEFLLSIVPAAFTGVRVYALRRSLTLCAITVVLSLVPLGCNFVQFGFGLGGKNVSPFGCTGLENISIVTITSRSCLIAADCLAISATWSTLDLQYLTRQGGMLKGSITSVLIMDGTVYFLILAVLNSLHLTLTLLSTAIEGLQPISVVTTFTSPISAILVSRFLLHLQSASLRAVGSSPSAQISSLHLGHSLVFEQVVGSLGASISAEDCFMEEGLGTGDNGERADEPNLSQTSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHP1</accession>
    <name>A0A4Q9PHP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145221">
        <property type="protein sequence ID" value="TBU53191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHP1"/>
    <dbReference type="OMA" id="YREQVEW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039470">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15891">
        <property type="entry name" value="Nuc_deoxyri_tr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19953" checksum="10F13FBABBDA72B5" modified="2019-07-31" version="1">MSTTGLDSSTAATEKPVRVYQAPEPLPSTLASPSVFLAGTITGTDWRADVIRRLEHLLNTNRNPITLLNPLREDWDSSWVERKTDKRFCEQVAWELDAQKLADMIAIYLHPGTPSPISLLELGLSARDKGKVVVCCPDGFPRKGNVEIVCERYKIDLVETLEELIENIAKKIGACRPHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ31</accession>
    <name>A0A4Q9PJ31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_104796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ31"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="15089" checksum="44614664068D9E41" modified="2019-07-31" version="1">MPSKSSAARYRLARRIAPAVLRSWFPVYRQTDASVFRIVIHAFPSSAYVISASLVCLSLLPLTLMFPSLLSFKGLRYIRTHPHMLSCCITTSPSPRCFTSLSVRACILIHAFTFYPLSHFLHVLKGSAHRCYSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJG5</accession>
    <name>A0A4Q9PJG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_97233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJG5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30991" checksum="7F684361E1D864E7" modified="2019-07-31" version="1">MTTFYSGTPSARSSGRDENGPGRFLFTSSIAISPLRGYVSDTFLTVPLAAGICEVVLCVENVVALVSMLCAQLISFVRVYALYGKRKRLLVALSILCVVQIGIMATFLGLTLLSISHLSDAIIQDSNCYPAIPPIAVFFWVPALVFEPVLCALVLWAAWGEECAHRFRCAIGQSSSPPGNCTDTPDLVKILAQDSLIYFLGIFIELAVNAILWINRSSYIRAALPWSYVLPSILGSRLFLSMREAVLFPESCDRQRGVLRNMMSIGGPSALEWAVSTGEDVGIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJS8</accession>
    <name>A0A4Q9PJS8_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_828201</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PJS8"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="482" mass="51650" checksum="1400E354BE03B7D6" modified="2019-07-31" version="1">MVAVAATTATSRVPSRAPSVAPSASRARTPSFVQGQEIPSSPLSPTPSSIADGDAVFDLMDVDLDAESSALVAGPSRSSHSSRAASPVKAKAKRHAVAEPPRKKARRDNDADISGARTKPKHKIERSRTPTFTDSESEAEVQVQKAVMNVPKRIDAKRLSPEPYPHLAKAAHKKRPRAILSDDETDLDASPAAPPPAPKKDGERERKKDKPKKPRAKGSALDPELENEPLHASMSAAKPKAAKSSSAPKSATNIARPELPSAPVAPAAAKPREAAPHKAKPFTSTAAAGKSRASRAHDDDAESLVNVYELPLPAPELEGMLVETLATARASSLATSALYGALMAARPALRDMALPTLKDPVVADEDDQEKGRDATGRGRGAKADAASRRAWVPAIEAILEAGWRRCGVFGKVVNSGTDLANHSLSLEARWFYDPDRDADADRATLVRSMMRRPGKRSETKKAKQYYWRPLPKISRWDAEDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK43</accession>
    <name>A0A4Q9PK43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_935864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK43"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="514" mass="57804" checksum="C62658CD7FEBA48C" modified="2019-07-31" version="1">MKSMHMDRHDAKARTALNLDVLRTVISFLPVADLKEIAVVSQPLHEEASREILSRGVHLRSNATKLKSFCDFMLKRDPPLFPYLRTFTLEHLPHRYVDQTAIDPTEILEVLSRAVYLRYLRIRWSDFLFTAESDKRLFITLPKLPDLRRLEVWTRSNTTDTLVAETVLNLRSQLRTLDVPSDPDNQLSPDFPNLLAEKQQSLYSLRICYPSLTNTQWAPFPSVRVLYLQIGDKLPSLPQLAQIFPALRELSVSAVGFEVDFAHPSPEHVRARNEALAFQNSGKGWKSLDVLTAATIGDPWVLCLTCPVGSVSLGHYDVGSHRAFVDVVSGTRPRKVAVHLACAQYCVRPDGLQNIFVFPSGVEDGTEEGVRGVTHAVLMVSISSFNTGQDTATIIDTIASHVKDSALEYIHIGFAEFFMSGELDERILKPEDIHEEVKKVIQEIDLELLVSGIVAAGTRLRFVAVTAATRDQSMWAIDRTDNGQLVGRVKNAFPAREIIDREERRHKGTGWFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKZ0</accession>
    <name>A0A4Q9PKZ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1041508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKZ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKZ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179">
        <property type="entry name" value="PROTEIN CBG02620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35179:SF2">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
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        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
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        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="617" mass="66537" checksum="7E6C4566A4405B5B" modified="2019-07-31" version="1">MASTNGTPEEGEVCAVAGSSVTTLEITEDVRAAMSTASSPTRAAGEDAAGEAGTLSVADSEAADVGSPGPQTEAKGALALADSLGEPAEDNLPPACDMRENILEPAIAELTAPNVADVDKPTKIEDFRPLASYTWVKGQHPTIIVPGSPREWLDSPMPFTVDFDSGIRMFHEDAYYMANQSTLVPLFRAVDALASSVSSGPDVDSNKDMIDWAAIDFVTDRNNLRKLLRWIREPFPSDAAQPLSPVSEPSLERPTRDQGERKEGSAATTAPEWDTRKDFRIDLQLGGADTVLMHRWAARAREVAVPPKAGCRLNFEREATKAAQGCENGAGHYRIVQYTICGLKMVVRFEVDACVATSTHVTPPHTDGDETRTEDSARELSERASGSIPVAPTEKVAGIQARQSFTEDEANMWVVGSAAEDWGFREAPTQKGKQTSGDDRGQALPPAETGWELPADDATAWGVAPDAAQNADLPIIPGELAVVRAGTLLPQSSILELATRSIMFADRTSNEDTFLQLFLSQTPTHLLAIHTNGTFEKVMRQGLDSPEFTGIEEMESIQKCIAQFVALLKEIHRLVKEHGTTRRLSLVCEKGKLELFGLKGEEGRLAGGDLERFKATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMA3</accession>
    <name>A0A4Q9PMA3_9APHY</name>
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        <recommendedName>
            <fullName evidence="6">HIT-type domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="7" type="ORF">BD310DRAFT_933945</name>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMA3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMA3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039723">
        <property type="entry name" value="Vps71/ZNHIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13093">
        <property type="entry name" value="ZINC FINGER HIT DOMAIN CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="6">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU55285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="180" mass="20277" checksum="27AFB6A054B79DDD" modified="2019-07-31" version="1">MPPARRQPTRQVQNPNSPLDREVIAKRTKRHLEELERSNYSEPAGAGVATSGEAEDDDEGVAPGGRTTKGRARQTTISDKRQWEQVGTKRPKKATMNVRTAILYKKSFNVLLEESGIEHMPPGVPTYLRAAAPPPREPQRLLCSVCGYWGKYKCKRCAMPYCDLNCEGVHNETRCERRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMC4</accession>
    <name>A0A4Q9PMC4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_950835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="2"/>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMC4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMC4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="5">
        <location>
            <begin position="43"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl transferase C-terminal" evidence="6">
        <location>
            <begin position="277"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU55380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="409" mass="45854" checksum="1DE49E12D50D2A4C" modified="2019-07-31" version="1">MAAKSVTRRPIPGHRAQRRHRALNSLSLLSLRLYSSTSDLFDILFFGRDEFSCLVLQQLLTAKDVWQDIQIVTQPDTKVGRRGSKLSVSPLKLLAEDARLQVHTIPHVRSEFRTWKAPPPFTFDTDARPNPTPAPNHLLVTASFGRILPNPLLALFLPTRRLNVHPSLLPLYRGPAPIQHALIDGRRETGVCVIEMTERKKGIDSGAIWRSERMACLPSRQYPPVGIPDTADFPTLRDSLARTGGQLLVSVLRDMLAGKDTRIPQPVDPDAPRAPLITAEHSMIDFRTMTASRVVGTHRAISHQKPMAAMLKIGRTLQLHNPCVLTEVYADIKNHLPTEGTAKFHPPSGAIVIRCAENTYLSVPQVRQQDRHLLKAKEWWNGVKPEMRLTEGLEGPVHFVPFDSVTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMK3</accession>
    <name>A0A4Q9PMK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactose mutarotase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_969245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMK3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMK3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF0">
        <property type="entry name" value="GALACTOSE MUTAROTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="430" mass="46277" checksum="C7B7A6498428A89B" modified="2019-07-31" version="1">MASPTDPEFTPILLALPSLTPSLALEIIPRGLVLHRLFVQADGKTHDILIGPEDPTGHLTQKYTNTIIGRYANRLPVGSFSVSRNNIQSTVSPQANEKPTVSLHGGVKGFDQYLWEPLVDPSASELFTPAELATIETRIPSSIIFKRISEDGEEGFPGRLLIEVLIGLAQPEGAPRQTPEGKEWNLGSVVITYRAKLLDENKVTPINLTQHWGFNLDASLQEGPETLSVKDHKISIKADHTIELNAEALSTGTLLPVTGTHHAHAEKTSGRIAESFPESGYDEFYVFSPRAVPPPPTTLPASELKPELDLVGAALSRDSPASEEVVSLTSGKSGLRLGFATNQVGVQFYTNNFATPEKGARKKIHGGSGAVGDGYGPGTAAFLEFHAPLAAWLHPPESRGPTGDDTLLASGEVYNNFVRLDVWYKGSSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN14</accession>
    <name>A0A4Q9PN14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_950693</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN14"/>
    <dbReference type="OMA" id="RICVHEM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU55576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="445" mass="49732" checksum="726E8A298E28CA23" modified="2019-07-31" version="1">MACSPALLDAAAIVVALLILNRLFGNKPARAGPLPPGPKGLPLIGNLLYMPASHEWQTFAQWGQRWGGIVSVTILGQPYVILNSEKHAKEMLEKKSSIYSSRPVIAFGSELVGWKRILVLQPYGNTFREHRRMIFQLIGSKKNMARFVPLVDAKTRDFITEVYREPESLLKHIRKYVDPLGSFHVHWRYHPDDVLRIPDKDEGDPLVELVNRALEQFAICTAPGAFLANIFPALVHIPAWFPGAGFKKTAAAWRATLEQMCEDPYNLVKQQIAAGTNVPSFTSKNLEGDITPERELIVKDAASSLYAGGADTTVSAINSFFLAMTLHPEIQAKAHAEIEAAIGNDRLPTAEDRKNLPYVNAVFLETLRWNNVAPLGIPHRLIEDDVHDGYYLLKGTTVITNLWQMLHDPETYPDPGSFNPDRFLSYPGHEPELDPRTIAFGFGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN25</accession>
    <name>A0A4Q9PN25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_933416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN25"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="22"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="245"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="700" mass="78794" checksum="3C8477F69492F376" modified="2019-07-31" version="1">MWLLHTTTLELREFSDPTQVHYAILSHVWNTQGPEATYQDVKQIHSAVIRDLGDDPSHDHVQEYLSSRSTLPSKIRDFVAVARSKGYEYVWIDTCCIDKTSSAELSEAINSMFQWYAQASVCYVYLHDVDGSEHPAAPNSAFRASRWFTRGWTLQELVAPRYVAFFSRDWTLLGTKDSLANVIEAVTHISTTVLTHGVALNSVSIAERMSWAAERTTTRIEDRAYSLLGIFGIHLPTIYGEGHQSFIRLQEEILRRIPDQTLFAWGRVLRCPTDELHRLATVQFESRQDNPLQLDDSCLLAPSPTYFRDSAQYSPLPLRSLSQKIGSPLEIPQYTTTSYGIRTTLPICFVSLGNYGDGSMGDVLILAILACCSSEGALLSIILSPAGEPDRYFAGTGVHQITFDSAFTIPLEASIHDRAFHPRMMLLDESFLLRRFIASPIEVRTIFILHSHMTMLRVHEKKRRTDGFRSADRCEIILPPWTRSHLQGLGFECSFNDDVHQEPAWDRSITFSPTKGYHLTLLCPKVILHIRVYLCPLIDPESYANPWALHVVVTLTTASRTQMERSGMSSRIDISDGRIGAEGCGRPECHVHQWEAGSKLFYDMVRLTFANWRSVRGGARMLNTGSSFALDIEIKKEAAAIRDPSSPSPHVNIPAASSPAGNSNADALRRRKARQVRFHESVRVELYERGSDKKPSAPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ61</accession>
    <name>A0A4Q9PQ61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">DBR1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_950034</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ61"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000035">
        <property type="entry name" value="Lariat debranching enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU56483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="533" mass="59953" checksum="27B865A1D8DAF6B4" modified="2019-07-31" version="1">MCAPKGATLLGAPRITHLALLVYLTFAPLRIIQTAHWILAISTGVISLPRKLRNSLRCALQKRELRTHEFDMKIAIEGCCHGELDAIYSHIASLEERNGYKVDLLLVCGDFQAIRNYHDLQCMAVPDKYKKLGGFLKYYTGQAKAPILTIVIGGNHEASNYFWELYHGGWLAPNIYFLGHAGCVQVNGVRIAGASGIFKAQDFRQGHWERIPYNHSSVRSIYHIREYNVRRLSLLSSPAVFLSHDWPQGIEHHGNLRDLLRRKPYFRDDINKGVLGSPPLMGLLRTLKPQWWFSAHLHCRFEATVLHNSRDPDASSIRDATKSAEKTNPDEINIEDDVDTEPAAAAVPAEGRGIAPRNTDEIILDDEEEDVEAPPTPLPPPTETKFLALDKCLPRRQFLEVIDVDIIPPGQHREDGLVLSFDPEWLAITRAFHQHMTLSRTQSSYPDETSARDAVQREIGWIKEHVLANKDNGIIKVDDIQQFVMTAPAPAPEDKDTRAQPPYYPNPQTAAFCELLQIENKVNLIVPESGSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQB1</accession>
    <name>A0A4Q9PQB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_931372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQB1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQB1"/>
    <dbReference type="OMA" id="GNILFWP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="126"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="738"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="826"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="879"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU56532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1034" mass="118272" checksum="D8F19E9099A16986" modified="2019-07-31" version="1">MSAALNTQADTSAQSSGTVPDISLGSFTSTFSTPARKLRIPSASTGTTAVSPPNGSFAKRRAEEATPISKRFGHADDGEEEDGDVLDTPDGRKGSERWGDTTTDVSAPGRPKRTRSAGTKGGTNLTLRDQEKHIDALKKENFNIKLKVHFLEERLAQLAPDQIDAALKQNINLKIEVQQRGMEIKKLKKLVLELQRELEHSQRAGGAQSRARELEEKLAEREQELRELRRRRAIGPDDGASRELEARNAELEEELGNVRGLLEENTEELERLRELAESRDDHSSLGSERWRRQAEELEGENEELRARIDELEELAVQRTDERDDLADEVEALRLELEDLQRRREAESIERSHSRAQILEEREGREAIEEDLNAVRDKLAAAQIELQQKEDEIDMKHREIEELIAEHQRIVESVEEEWRGEVDEAKGQMEELRDALEQRDAECKELRLHIDEYEANAEDLHQKFEATLVHLEREAEEKDNELEAANRDLEKMSNQLYALEEENERLKEEMERVREDEADERDRLEQLSAALKQKVAQLKADLQELTDLYNTRDAEAQEHRARKEELAQHIEKVVQELQRERAVRERLEVDFDKAGKEHDDAIRQERRALEAKESALQSALNDLARAQSLLTQREADLAAVQTALQTLEADNKKLGESHTTARFSLQLEVDRLRRDVERLEDELARARKELDDREGKGRDRDGVIDKLYVENRDLATQLAAETQARLNLSEKLDGTQASLHTAESETANLRTRVAELEQRLSKDQRALLAAEAQYRDQLTERNTLLLTIYQYMDKIVGVDKTPKKYGQAETKPFTNFSVFHDNLITRLKALSQIQSDFEKRVKEAEQRYSDKLNDMRKQLDLRWKQIDKFEASVKTLAEAKATWRKKLSAKEGEIEALQATNAALQSAVVTRKGNQADSMEIRALTARAQNAERRAINLQNQLVQSEEKLTAVNQKTTVADSKWEARVKEYETRLKTAEEKIKREKQGGKERASELENQLKSLQRQLELANKRTSTLNEIIETAGLSAKGSPALGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQW3</accession>
    <name>A0A4Q9PQW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_823043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQW3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026680">
        <property type="entry name" value="CCDC137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21838:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29429" checksum="A84E46EED736C77A" modified="2019-07-31" version="1">MPHKRAKRSMREKQRTESGSDLAPGAKKAIENEEIPKSAARVLNAAKVQQEFAERKRKGLDSDEGSAGPSRKKRKRDEGAGKSEGGGEGEGRKKAQLRIMAGESMAHFNRRVEDSMRHLVKEAIQTSSARVRQAKKEELASQGSKKAAAAANPSSKSRATSGPARDDEDSEDEDGRPAARAKAKETGPKEFQKVDTSAPRRLNDVAQAPPELKKLPRKAKKLAAMGGGTNASGATSLKDGVLSMAQKAMMEEERERAIRLYREMKKGKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRL7</accession>
    <name>A0A4Q9PRL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTP-binding protein ypt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_930189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Lipid-anchor</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRL7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRL7"/>
    <dbReference type="OMA" id="NVKGWIT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="173"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22628" checksum="FE430F623FCC3E4B" modified="2019-07-31" version="1">MPDGYDYLFKLLLIGDSGVGKSCLLLRFAEDAFTDSYLSTIGVDFKIRTIELEGRTVKLQIWDTAGQERFRTIAAAYYRGAHGIIMVYDVTDGETFSNVKGWMQEIERYASEGVKKLIIGNKSDLVEKKVVEYSLAKDFADTVSIPFIETSAKNSTNVEEAFSLLAKTIKDEVDSQPEEASNGTKTSSVTPGRSLNGDEDAGACSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS32</accession>
    <name>A0A4Q9PS32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_881294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS32"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07822">
        <property type="entry name" value="SRPBCC_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019587">
        <property type="entry name" value="Polyketide_cyclase/dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36166:SF1">
        <property type="entry name" value="SRPBCC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10604">
        <property type="entry name" value="Polyketide_cyc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19948" checksum="B1F70149403B8D96" modified="2019-07-31" version="1">MPEASTNLPPPSYSGPLTCYVSREISATIERVWGVLSDFPRYPEWNPFVRSQEITDKSGKTVLEDQTPAKGKYLNMKVHIPPTMDDSVQAQTAFELIIHYDDASHRLAWKNLLPSWFIRAERWQALSITEDGKTLYESREVFAGIGAYLIKWFISKNLIKSFEAMADALKSTSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSG2</accession>
    <name>A0A4Q9PSG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_554588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSG2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PSG2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="33254" checksum="EA9B7B7A9C2874FB" modified="2019-07-31" version="1">MPIATMAVSSSSTFNNQSRNGNVLSDTQHLFSVEGLVAVVTGGGTGIGLMIAKALEHNGAIVYIVSRRLDVLEAAANEHNRRRNLIPLQGDVTDRESMRAVAQTIRERHGFINLLVNNAGLARNFLPKLPGPGEVDMKKYQELLWNAGTPQDFADSFDVNVSAVWYNTVCFLDLLDAGNKRGNMPGVTSQILTVSSGGAFRKDDKVFSVSYTLSKSAATHLGKMLAYFLKDWQIRSNVIAPGIFPSEMVDGLISDEYVRAGVPLHRAGTTDDMGGLILFLTSRAGAYLNGTVQLIDGGRLLLYPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTZ3</accession>
    <name>A0A4Q9PTZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_509795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTZ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10011" checksum="66AECD5C06BE8E93" modified="2019-07-31" version="1">MLTGVTGTSRSYFIPVEVCTYVPDDSIRLFLSCCSNVSIACPMAFLFFCVHLTLSGFCLCIYGRLYLFVISIIAFVALDKGTKTRASSRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUJ2</accession>
    <name>A0A4Q9PUJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_499275</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUJ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="504" mass="57381" checksum="8D96DA4CAF48E280" modified="2019-07-31" version="1">MEHYYLFAGPIALLLYGLYVRSPAIPKNRLPPIVDIPAEDIFSRPREAYGEALATYGPVIGVRRKGNLEYIVNQEYARHVLTCDRLFSFEQGSAAIMNLQPIMAFTQGTLFRDLQDFVRDGIVNRIDEIVYRIWPLFQKDTKEFIDLAADGLKSGKHPNCFEHFHNTIAETTLILLLGQDYVNEQNLLIIEDVSNGMAELTGQYQNFSMIGRYLPILWILYTWVKVMLITIPFGFLRKYGPKVWRDIDRYEEISRSRKLSPKDEPRTVLYLIVKTYMPRDGKRISAPRRLYIAVLLLCLIFAAVHTTTVVSQWVLCQLAMRPEYLAPLREELASVLEEDESGALRLTAQSLRQARLMDSFIREVMRLKGDTISAMRYTTCDVPLGDAILPKGHFVTAMSTTVHENPDVFGEQPREFNGFQWAELGKEAVMTGPAHIVFGLGRFACPGRVLAVNEIKLIVMSLIARATPTLLEGRFEVSDPLNTVTQPPKGTLVFQPLEKPYLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV08</accession>
    <name>A0A4Q9PV08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_819434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV08"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV08"/>
    <dbReference type="OMA" id="NDPFFDW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF153">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="56"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="314"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU58442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="375" mass="42931" checksum="B8427B74C4AD8BF1" modified="2019-07-31" version="1">MLSHEHRASISTGRTSLHEWVKETSQVMQQSQRPIQADEVALQMRRSKGSYRLSDFIIQRTLGTGSFGRVHLVRSKHNLRFYAIKVLSKEKIVRMKQESHTRNEQMILQAVQHPFIINLWGAFQDTANLYMVMDFVPGGELFTLLRRSNRFPDPVAKFYAAEVALALNYLHSKDIIYRDLKPENILLNFDGHIKIADFGFAKHCTTTVWTLCGTPDYLAPEIIGNVRYNKSVDWYALGVLIFEMLSGLPPFHEPDISPVVLYEKIAQGPACIKWPAFNANATDLILKFMERDPSKRFGNLAHGAGDVFAHPWFAEVDWKKLLNREITAPYLPKIANDGDASAFERYPEENAAARYGEITRDLYGEHFPDFEYTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVG8</accession>
    <name>A0A4Q9PVG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_926962</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PVG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="599"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1121"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="290"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1357"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="58"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU58449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1401" mass="157894" checksum="DF055017AFB23728" modified="2019-07-31" version="1">MSKTRSSRHAPSAGDQHTDSRAGASEPVQSPPRKRRRTVDTHGDPPSRHNLRSVATMPDSSSPQLPLSTRPSRPSNGATPGGLATTQLLSPFKHPIPRVKLLVRRPPPTYTHPGQKPPAPQYNGSLDALLSSFTYRDGAEVSSSELAASLSDELALWRKIDSLRKQGRLPERSSYEFRDIQPQDAWAAIVREVERPGTRFVDGREMAGNVAGKVRKYWEMENRAEEARVKGLARAAMRMVVGQWKKAVYHVREQARLEWEEEERRRGQEHLDAILDQSGQILEVQLHDLARDSRSRSHSVSTHGRDRTPVDSDDEGTGDSDDEQSGMRRGDDVSEESDSTADDEGISMLVPDLEFEGASPAGRSPRSFSLEVESTPSDGTRDFFGDGRVVGSPERVFADAMASGELFDRDETGRDALRTPLLTSTAMAMEVDEATLQSTPIGVSTQQQQKNGRHSLKQSSDHSDRVESEATVATLPQVNGKSVPWLPQYKKTPLLEELASTPTPLVVSEAPVAEVQPATFRGNDKSGAGTPVELPGDPTPAIDDDVQDDEVEEDSSIPYYLRPYAVAPVERDPQAKVKAPLLLRGTLRPYQQSGLEWLASLHARNLNGILADEMGLGKTIQTIALLAHLACDRGIWGPHLIIVPTSVLLNWEMEFKKFLPGFKVLSYHGNTKQRKELRQGWNNKYHFNVCITSYTLASRDSHVFKRKRWYYMILDEAHMIKNFKSQRWNILLMFRSFRRLLLTGTPLQNNLTELWALLQFLMSGTDFANLREFGEWFANPLERAIELGAIDDETQQRVSKLHQVLRPYLLRRLKRDVEKELPQKYEHIVMCPLSKRQRFLYDEFMSRAETRHDLQSGVYQKIANILMQLRKVVNHPDLFETRPIVTSFAMQRSVVADYEVKELLVRRRLLAEHDEGKVNLDFLGFKFVDNLGQSEVAAQETLRLDGTAYLPMINEVPGEPPPADTRTITGFKKYREYQRRAATIARWTQIGYINRHRCNCLRVPVYSSETLALVQRFHEPLAPSGVNMRPAKYLLTPEKVRSAIKSYASRAEDMTPVIEHFAFATPSVVARDLPLIALSSVPPALSDGPLVDPEFDAPLHRASVKLQIAFPELSLLQYDCGKLQVLAKLLRERKAGGHRVLIFTQMTRILDILEIFLNFHGYLYSRLDGATKIEDRQYITERFNSDSRVFCFISSSRSGGVGINLTGADTVVFYDSDFNPQMDRQCEDRAHRIGQIRDVHIYRFISQHTVEEALLRKANQKRSLDDIVIQKGEFDWRTLFAEGDISEGALTRALGEFEDAEDAQAARVAAQEEMELEDEDAQDFGNEPAAAVRIAQSEQVDVVETPVEVSVRALEDIEDGGAHHAGEEGEGEEEDGRTIDDYMIDFVKSDPEFFNATDWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWK2</accession>
    <name>A0A4Q9PWK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HSF-type DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_818780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWK2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWK2"/>
    <dbReference type="OMA" id="ENQHMIR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000232">
        <property type="entry name" value="HSF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00447">
        <property type="entry name" value="HSF_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSF-type DNA-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="84"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="342"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="507" mass="54387" checksum="D86202A6B3146926" modified="2019-07-31" version="1">MIRWDPAGEHIIVERPEQLALHVLPSVYRQSRFASFSRQLNIYGFMRKVNLRNVDPAIDDPDASTWSHPTLNRHSPPEVVANFKRRVPPRLPKPRKQTNDVPQIPPPRSAIGTGAMPFSMPSGDLSPYNKGGRSRGFSAPGSFTPLNQPGAAGWGASYPRSTLPPLNVPSDPPLSSHGGMYSHSSHTLHPVTPTEDTQSSAFGSMSYSSSGRDTMILPSPSSQYQYSDQQSNWSFSSGAPSAHSTGSLSSLLNPTASSTSLASGYSGSSRPQPAAINTYTSSYAPLSRNHHSAGPVSPDSRPTSGYSASSMSSLPTPYEDQSAHHFGGHDYSRPSSGHHRPMSPSSSRPPSSKSYANGSSLSVRRERRHSQAMSPYPSPYSEHPSQRPSTSPHPAEDHAGNSGIPRVRSMIQLPSVDNYSFNPAQGDFAYAVDEQNQGNGMYGVPGSRSVRPSTSASSLSTTSSAANTPAADGYGNGAAEADITRYSPDYGFVPMNEHLPQYAKNEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX04</accession>
    <name>A0A4Q9PX04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1012210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX04"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6513" checksum="89890D8C81BD14BC" modified="2019-07-31" version="1">MSSSTMPCATSVRIATTSIPDVPLWIKNHFHTYDRPECMLVCGRNPYRGGSGSEASVSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY76</accession>
    <name>A0A4Q9PY76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_924806</name>
        <name evidence="7" type="ORF">BD311DRAFT_754004</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143404">
        <property type="protein sequence ID" value="TBU30589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY76"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY76"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU30589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU59496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="22455" checksum="FF197B05BE75E094" modified="2019-07-31" version="1">MSDTPSWPSLYDPLVELFPLDHRDAVQRKGRYLSHPYDVFRFTLYWTLVLYVPSFIICGAYAFFNLSLPPRRPNRRGYKVRPGIASGGPSFRSAESENIPLRRYGRQLGAGGRSQLRLPSRAPAKQNETRSRLTFAVLVFMLFATFALGGAVVGSAIIGYVLAGLYKAGKYHMSTWIPLIGAVLQTLLGFLALWPTVIDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYW4</accession>
    <name>A0A4Q9PYW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bicupin oxalate decarboxylase/oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_957879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYW4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYW4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020322356" evidence="5">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="135"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="322"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="477" mass="52079" checksum="455E850DC14E56F5" modified="2019-07-31" version="1">MLPRLSHVLLAALALSRTILAEPSADDQLKAFFARERVAVKPVNFGRRSAATTPTRHLRPEAFEDEAALRKRDSLTPPDVGQVADWGGSNPQPVRNGAGDTFLANSNHQIDAQNPDNVAAPPTDSGTVPNLKWSLSLSHTRLLKGGWVREQTITDLPPSKDLAAAELRLSPNAYRELHWHRVAEWGYILNGTGRISAIDENGRSFISDVHGPTNGTDPDIYYFPPGVPHSIQALEDGLEILLIFTDGNFDATGTTFMLSDWLARTPLEVVAQNFGVNVSLLGGIPQKDPYVFDSTVAPPPFGHASEQAVKDPNGQVPSPYVFHLSDQERKSAPGGGGWVKIQDSVTNFPVSTLLASALVFVEPNGLRELHWHTSDEWLYIISGNARATAFAGSSSSRTFDFQPGDTAVFPVSYGHYVKNLSPTEPLIYLELFKAPKFVDFSATQWLALTPRQVVADLLNLSTSVIETFKTEKQVIVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYX8</accession>
    <name>A0A4Q9PYX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_373207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYX8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF12">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU59800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11926" checksum="4014E414A043C128" modified="2019-07-31" version="1">MPERFLDQEGQLRSDILDPQLLVYGYGRRSCPGRHLAQSSLFITIAFLLHTQDILPRLDQFGAPILPKGNMAHRIVSHPEGLEFRVRVRSRQAETLIQSDCAESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZX3</accession>
    <name>A0A4Q9PZX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_816348</name>
        <name evidence="5" type="ORF">BD311DRAFT_657837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143402">
        <property type="protein sequence ID" value="TBU30920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZX3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZX3"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="92"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU30920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="20408" checksum="F6EA9C8A359D4784" modified="2019-07-31" version="1">MCDANDYSKMFVGGLSWDTTDADGLRKYFSEFGEVEDCTILRDQDGRSRGFAFLTFKDPASVNAVMCREHILDGKTIDPKRAIPREEHLRNTRYFVGGLSHSTTSDSMRAFFSQYGKVVDCTVMVDRESGRSKGFGFVTFEDASNTDQLVGQPNLILDDKQVRKTSLLSRSYTVRNELIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZY4</accession>
    <name>A0A4Q9PZY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_815509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZY4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZY4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="357" mass="37668" checksum="F4CA1D81EBAFAA2C" modified="2019-07-31" version="1">MSVPSHQKALFLEAKQGQWAVRTTEVRKPGSGDIVVKVEAAALGGVEWKIQAWGILIKDYPAILGMDGAGTVVELGEGVTTFAVGDRVMFQGNWDILTGTIYGTFLQYFTAPAQFVAKIPDSISFEAASTMPTGVATATLSVYNQADYALSAKYFAPWLPGGRGKYAGKPIVILGGPTSHGQYATQFAHLSGFSPIITTASLHNADLLKSFGATHVLDRKLPAEEIRARVSEIAGGPVGLVYDTVSVSATFPLAVALAAPGSTVLTVQWAPEELVAQAMKDGKAVHMVLGFYNAPVNREIGATLLASLPELLESGDIKPNHWEVLAGGLGGIVGGLERMKNDQVSGVKLVARPHETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0Q7</accession>
    <name>A0A4Q9Q0Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_921976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0Q7"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="23710" checksum="AB9A0D450BD027C0" modified="2019-07-31" version="1">MHSNHKQIPPLNRCIAISAQAFHCSNKAPHPQPYCTEHADECRALEKRLTEITKQTWRRRDVVRDLIAEEWERDEFVDDRYAGDEQDVRSYLESIDDQIGVMVALKTRFFSRNEGTVSMDVLKEWKWRAVVVLSDLGRPMAAEGEWDYHDDYHDSRDFDAYTMYTSDDSSASSEGTHPMEDPATGTVARNEGWIAGIIRAVIKALM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q195</accession>
    <name>A0A4Q9Q195_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922195</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q195"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="168" mass="18358" checksum="E8B8F86104A6BE6F" modified="2019-07-31" version="1">MRCKKRYSAPQRPHATSIHEVHDTVTEACSTFEPERGRRRACSRSGDCAAGYCTRGGTVKFAMDVRELVAGCQPPAHSTAGCGDTTFLRTLLHSNAASAFDSCSGSCQITLRVFECVMRALDAAYVQCSHLHKCAKGWAWTQTNLRTTGDTPAERGNPRVRLRVCFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1V5</accession>
    <name>A0A4Q9Q1V5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_814425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1V5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41346" checksum="E1FC829B8A85FEA0" modified="2019-07-31" version="1">MVIRLKPNDNYPVNWDLYDLVNFLSGSPRLEEIYIGDISWRMEQVSFSSVPVVRAPLSLPRLRYLSLTYSARATESASHVVEHLLIIPPSCHLYFKARGGPRNINQVLLESVRRHVAGRDAVSHVCFWITEFSCDQSIQLVFPKGSLRLVFAASSFSSVRHAEDMFDLLCSFPQLFTETRELRVHYSENDLLRKLQSSFPTIFPDFTALSLIPFPGSGYSGHASLTIGLESLTEPPEGERKVTWPALDTLWVSVTDKRDATQLETALDFRALRGHPICHLTVRYDPRKKKGKSGGEGVESKVPSFAAAFEEHVKEITLMELPSREPRREIDWMVRLPERYGLPSAFHRDWPSCKYMQDGLCMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3A1</accession>
    <name>A0A4Q9Q3A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TFP11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_844728</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFP11/STIP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3A1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3A1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="974" mass="107841" checksum="06A1895D4D61BAF7" modified="2019-07-31" version="1">MARRKRQLLEDDDPDSSPVSDVDEPHFDDSDPDARAERELFENPYNRKRRRKNAKEDAIYGVFASDDDEEDEKVARRKARTRTKAPSFVTSGSKVTLDEDVDMDGSKASAEEDGGEKGEDVGEDVELEDEDAESSESEPSKPPSPRVREEEEEEEERPRFGGLGLGVGKGGIGSSKGGGIGAGKGGIGASKGGIGSSKGGIGSASAMPSFAKGGIGSSRPVAPESSASPSPAPAAAEDFPTAFGGARQQRSFLRNADSSTSTPRSATPLSATEQMHLSKISGTFGARMLAKMGWQTGQGLGTTGEGIVTPVESKLRPKGMGLAFKGFREKTEQAKAEARRRGEIVSDDEDSKPAARKARKAAKAHEARTDAWKKPKKTKTRVEHKTYEEIIAEAGQEAVPQAGVGPIIDATGATLREVSSLAEVAKASWTPSTDPMRLPEIRHNLRLITESCRTDLDGLAKEARALEERKKWIRVEDARLRKQVDEEAELIARMQHMNIVVDEINTQSREAASMYEASLEPFSAGFDKLLGEHAKEFDRYRLDEVVVAAIAPVIRRMLAQWQPLEDPTAFTASFRAWRRALKMAIPGDKPVNQVQVYGSSTVVSTPIVEEKPMTPYESLLWNTWLPRVRSSLNNEWSPEDPTPAVRLYEAWSSFLPPFIRDNFFDQLILPKVHKAVGDWHPRKSKVPLQTLVFPWLPHIGLRLEDVLGDARRKVKSVLRAWSTSDTIPQDLAVWKDVFDVGDWDTMLLKYVVPKLGSRLREDFRVNPRQQDMQPLQDVMLWERLLRPSVLSQILEKEFFPKWLDVLYIWLIQPNASLAEVSRWYEEWKKAFSENIQNTPGVSQGFTRGLQLMNKALELGPDAPTLLPRPDHTVPLSAGAAITLSRPKEKPKPARTQEVTFRSIVEDYAAAHNLLFLPAGKVHEESRMPLYRVSPTADGKGGVLVYILDDAVWAADANGAYRAITMDDMVLRATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3C2</accession>
    <name>A0A4Q9Q3C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3C2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10250" checksum="7B3D08CA47239CFA" modified="2019-07-31" version="1" fragment="single">MLVNELQSTVILLQELNQFSFASVLEHSWVRKHFAITPPDTKSWPWPPLYGIATLVLRQLQVDNAQMLQFLKTVMGRTAVFVAVSPQPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q409</accession>
    <name>A0A4Q9Q409_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_117072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q409"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6691" checksum="DA6CC54FFE123D93" modified="2019-07-31" version="1">MIPIFAVESTPDRPRRQARGLIASHPGTLPALSPSHVPLSPGRVNPHLRTPLRSQGCGVYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q411</accession>
    <name>A0A4Q9Q411_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Opioid growth factor receptor conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_904531</name>
        <name evidence="3" type="ORF">BD311DRAFT_674472</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143512">
        <property type="protein sequence ID" value="TBU23199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q411"/>
    <dbReference type="OMA" id="WWANCLR"/>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0675">Receptor</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="2">
        <location>
            <begin position="24"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU23199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="241" mass="28744" checksum="66962E20CE46E096" modified="2019-07-31" version="1">MSLPGDVREFLDNYPDLPDDPSLNSNLRFYSNLERCRPDNLLIDELHEQWKTDYAKLEYKHGYIQWLFPLQEYGMNFEAQPLQKHEIADMKADPKIIERLERSYEIMLGFFGMELVSKETGELRRVQKWEERYFNLARAPHNNLRISRILKCLSEFGLERYNAGFLLFVLYEQSANNILRSNILVNSMDRWWANCLRNPEERAWIKDTIQKVRSGSTDYVFTDEAYRDALKRRKETGKLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4K3</accession>
    <name>A0A4Q9Q4K3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein ral2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_811267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4K3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4K3"/>
    <dbReference type="OMA" id="DMADMEF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="585" mass="66032" checksum="B6D0A2C62C615033" modified="2019-07-31" version="1">MYPISDLTAFCRKTTGDVPPKLVGASTTVIGSKMYLYGGRLVSERKMVSDIYQFDLETFKWEKVPQSPDDDIPQARYFHSADTWRNHLIIFGGMAIKPQSDNPEDLCVLNDVRLFDLTTRHWLPGAPISADSSLVPNARYAHLSSVTADRLFIIGGQDLANVWLDDVYIFDLVARTWIQRRDYPRHCGTYRSVAVTSDQRVRLPQDELRSLNQSTTRLGQPGTRFNIDKKAPPAPNVTQSESLIYLPYSAAPTDDYPCDIFLFSNYNFTDVQRELEVFTPLSDGDFTVSDRSSSMTGASFPPGLRFPTGAILGTFFIVAGTYLSQTYQSFSIWALDLINMTWSRIDPGSALASGSWFRSCLWASANKFVVFGNRHGNLVEDYNRRLLSWDHVTCIDLEAFGIYQPPPLQLDIPMQELGLAALEEGLMSDFEIICDDGRRIKVSRRLLEERWPWFREQRKLFLQAASRALETMPAVASHSPNPDVPTAVRQEPRPDPRLASRAFNLSEPYPIALAFMQYFYSMALITPLQHAPAVLSQLLLLSSTYQLDHLQSLVKHAMHRALSYATSVGIYGVSTLCSCRSLQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4L6</accession>
    <name>A0A4Q9Q4L6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_844637</name>
        <name evidence="7" type="ORF">BD311DRAFT_682164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4L6"/>
    <dbReference type="OMA" id="MPTEFEM"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU34405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7374" checksum="01E70D9E77464473" modified="2019-07-31" version="1">MPTEFELRKRNNAFAEKARAGKNPVKASRAERLSKRSPISLWALGVILFVVLGGVIFELLRLFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6D1</accession>
    <name>A0A4Q9Q6D1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_945585</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRG9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6D1"/>
    <dbReference type="OMA" id="TMKRKFP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="200" mass="23212" checksum="C951C34B747FE654" modified="2019-07-31" version="1">MLAAALRSGVPAKSPARYTLINLYTTVANLTRKQWRTGGHPAPKSLGHTPPEADDADADEPSRPISHRPHPLKPEFQPTPHEFRAYRETMKKKFPEGWAPPRKISREAMVSLRHLHQMDPETFSTPILADKFRISKEAVRRILKGKWEPTREERARLAERERVGRARFREERRAEEMRKHESIERESGRERAPRDGFTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7A2</accession>
    <name>A0A4Q9Q7A2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_808415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7A2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22748" checksum="C95F613D0DA37045" modified="2019-07-31" version="1">MRYFHVVGAPDKGEEDDDEALEAVTWDLAVACLALSVKFHRDVLFPLDVIYAQEFLDLAPHRMEFANLENAQRDVLEALAFRVGSVTPGAFMAELWEALPTLRILVGFDGGWDGVQDKAWDVLCDALQQQDLLRFPISLLTAATVTQGVLEVLVKRYKATGMNGRGKSLSKRDTASLRKAAKKCSRGVRLDIQEVLQISDVSGVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7G3</accession>
    <name>A0A4Q9Q7G3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_808761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7G3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7G3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33372" checksum="88C9F49907AC8651" modified="2019-07-31" version="1">MSLVPWGKLQIGTLAAVVQDLGLKPYTTRTARKHELVRLLQSIELEGLSPVLLRLQEERSSSQTSDHEREESPELEYLGAPPSGSSAPAPVRPVVEIPVHSSPRSPLQHRAGPSRARTRARTEPSPSPSPSPIPGPSGIGPLKSRKRQRGAHVEPRAKGQRRPSVDLSNVPPPSYAILYQERQNISLPRQEPWPLLNPYETFDGVVIPARQKKRARVEVERRQGDSEGTPELDDRPMIVGVWDEEGSVSEAGVARAERSTGDGASTTASVTGRMEAIVVTSAKASKAASSRRRQVVLSDDERGVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7I9</accession>
    <name>A0A4Q9Q7I9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_791784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU62966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5401" checksum="66A5A8226B9ECA69" modified="2019-07-31" version="1" fragment="single">MSSEIAIFYIEATGYIGGSALQAILAHPEADTFEITALVRSEAKAKALESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q827</accession>
    <name>A0A4Q9Q827_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_841972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q827"/>
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    </dbReference>
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        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="452" mass="48433" checksum="869E72E45960422F" modified="2019-07-31" version="1">MGKWTLEYHDEVLRNKIKNLVQGAIKRMKVEQDDPSITYEAFVEELDEGDAFTATLVDVLVKELAERKQRPNPGDRRLISERTAKSLRMQAAPLHVYRGSSLRDRARRSVPLPPPRPYGTTFHDILSDSDGDEEYGTMLGSIGQLEGAQINTDLYDAYLPSTYDLPGSMSRSSERNTISPHPPESSRSWLMNSPPPRSPSAGHATAGWLGLGGPGSSSLTRQGSIRRPHRSRTIDTSNEFAGFTSRRRSAIRNSTTQDDGPRGESSSDAIGRSSSVDATRLTEASSSATDTGARGGLDLSAWMARRRAGASSFGNITVDELGWPVANSNPSSSQMWYSLTASSPASPEPMSFAPLSRGSSTTDLNEDRRQVIAPRLRRGGLRPPESLLLHGPASPGTGPSLLRLASPSPPSPSAHVTSAPVEAAGESLTPPAQGTSVPPSASRAASPAIESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBR0</accession>
    <name>A0A4Q9QBR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBR0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="174" mass="19638" checksum="DAC7AA23749BCAAE" modified="2019-07-31" version="1">MFVKRPSNAKMCAEMRAWEKLQRTGKFLEDRLYADMLQKYRLVAGSDPGAADLATVERTTGARPTVSGTGYSDHFVPSIDSPGDTRVTGAPPLSATFASIDRDLARLWPDTYWTVSDSDIDYEIDGFVLIDEADTKGLVFWEDARWRRRKKQDCPSVTWSRFCGFLRPKGGTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBS0</accession>
    <name>A0A4Q9QBS0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBS0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7350" checksum="D2F1CB60DF7ABAE3" modified="2019-07-31" version="1">MPLFLFHPTRPPDSILNRGRGIRARRSPPAFELAFTSLITTTCSGIFAADSWSARTDHLAYTPSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBS9</accession>
    <name>A0A4Q9QBS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_972278</name>
        <name evidence="3" type="ORF">BD311DRAFT_801630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBS9"/>
    <dbReference type="OrthoDB" id="10444271at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597673" description="CBM1 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU34923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="67" mass="6720" checksum="1F9D932AB1B183C7" modified="2019-07-31" version="1">MRLSWSLFSVAVLATLVSAAPVDSVAIARRGAPGGGNSPDWKRTCPNGAPGCGEGPRVAPVADRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBX7</accession>
    <name>A0A4Q9QBX7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_914296</name>
        <name evidence="3" type="ORF">BD311DRAFT_670545</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143468">
        <property type="protein sequence ID" value="TBU25021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBX7"/>
    <dbReference type="OrthoDB" id="3527137at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597675" description="DUF7770 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7770" evidence="2">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU25021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18605" checksum="7F9AF4B26343AF79" modified="2019-07-31" version="1">MPVLFVRILVNMILGGRASGETSTQSVPMAHFRILLVLDDSSNSPLSIELNSVGLVTTTGLTRMHVISRNWTHSAGTTRVLAEQDVHFIPGHALPTVDTVLNLLVGNKRHHYMLHASGSGCRYWTKVVLQDLIRAGYMAPGSDSIVATIKDEIAKANPQILMLADAEGTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC75</accession>
    <name>A0A4Q9QC75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_805861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC75"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC75"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031037">
        <property type="term" value="P:myosin II filament disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903013">
        <property type="term" value="P:response to differentiation-inducing factor 1"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04515">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.200.10">
        <property type="entry name" value="MHCK/EF2 kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004166">
        <property type="entry name" value="a-kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051852">
        <property type="entry name" value="Alpha-type_PK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992:SF2">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45992">
        <property type="entry name" value="EUKARYOTIC ELONGATION FACTOR 2 KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02816">
        <property type="entry name" value="Alpha_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51158">
        <property type="entry name" value="ALPHA_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-type protein kinase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="137"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="20204" checksum="37BD1BBB7C9358C6" modified="2019-07-31" version="1" fragment="single">WNKTSFSEQDAGLVWLLEPERSVAMERWSGTMAHPNHADKRGATLTAFVHFAYVYSHRTLVFSDLQTSSGRLQNGGRGDILFDVMTHTESGDSGIGDYGETGIKTFLADHICNDICVELGLRDISDPLENRDRIRARHNEDKYNTDSSDDKDDEENDTRGSGLVSYISSREGNDTDDPEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCC2</accession>
    <name>A0A4Q9QCC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCC2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="436" mass="47480" checksum="04767BEB7D676341" modified="2019-07-31" version="1">MQRPQLLRAGLSTPHFQFGSLAGSQPPQFPLTSNFRAPTAPVAPNRGSPSTSTARASAAPASAPAPGPSPLDKLAVELLTLIAFYACTDGGPTGCSLALVSKRVRAASRPARFFSVSLMTSPAQIEQFLACYQAERARATDALPRVRHLCLSLFGKGLDSPAAAPSSAASGSAEAGAGAGRRPTSRAEFLAQMQRRAQNWRSAQDSLDERYNHVVPTLVRAVAPDIQTLALVQAQWRASTVVRCCFPRLRELTLVGGDPSFMPFGFVPEGRPLYPALKRLHHILAFVGRDVDFLQWATHAPGVTHLRVSRLDSHPRVTVDTLDQVIGDEGPDEVWAHLQHVMIEPHPAPPPAPVTTTAHLAFRDFLAHLERSKERARVPVAVLPPLEMPKMVAGMDPHRTCIMRVKREWMERVEGEGAGCWEEHMHMQRRGRGASH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCK8</accession>
    <name>A0A4Q9QCK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_1001664</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCK8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="59576" checksum="305B0E5A7939EE3A" modified="2019-07-31" version="1">MQSSNIACDVSTHRTQTPETECTTISFPHDISSREKRLQISPPPLRTPEVLLPERSRIRLASAFFALLTLGWGDGVTGTLLPYFERDFNLSFMTSSLLFVASALGYALGTISVEFVTRILGRGRFCTSKLPSLFSFPSFRKPEPEPHEKDESIMGFSISRCRFFTMVLASILHSTFFVVMGCKLGFPSMMVAYAISAFSRSFILGARDHNVYVSSTSKRGLGYMYGSWAIGAFGAPLVCQSVIATGIRWANFYFGSLVLSGINTSLITFAFRPTPRELQQDADFAWSLLRSSTSSPDAVSPATTMVSNPQPSPTDSSAPILPGKVVGPHSEFDVRYRRNVGGSSNSYSTALRKPKLWSSAMFSMLYTGSESSTQGFIVIYLLNIRSANPDTVGYVTSGFWGGMAISRFLWGFLGNIVTFRQRKWIVQACMYLLPVTAACMHLLIWFVPSFIENAFSAAVVGLMYGPIYPANLATARDLLPAEVHLVSLAIVAAFGSFGAALFPFIAGTLSTVVGPRTLPYLTVSQCVAMFCLWSFFPSQIPGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCZ3</accession>
    <name>A0A4Q9QCZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_971736</name>
        <name evidence="1" type="ORF">BD311DRAFT_744617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCZ3"/>
    <dbReference type="OrthoDB" id="2713757at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU35792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6338" checksum="B4696FCBDDA15289" modified="2019-07-31" version="1">MDPFPIGTRVFFLECGKTRTGTVQNTETIEGLRYVVIKLDDGSPNPVKLPVNSISKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDU7</accession>
    <name>A0A4Q9QDU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Metalloenzyme, LuxS/M16 peptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_971629</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDU7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDU7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000003">
        <property type="entry name" value="Insulin-degrading enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000005">
        <property type="entry name" value="nardilysin isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="52"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="261"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="12">
        <location>
            <begin position="447"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="13">
        <location>
            <begin position="850"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="234"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU65520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127521" checksum="3B55D1DEFE717C40" modified="2019-07-31" version="1">MVAFPSDSAGAWTRVTSGKIPYDVYTKPINKSPQDDREYRLIRLDNGLQAMLVHHAKADKSAASLDVAVGHLYDPDDMPGLAHFCEHLLFMGTEQYPKENEYSEYLSKNGGSSNAYTGTSNTNYHFNVSPTALPGALARFAGFFHSPLFAPSCTVRELNAVDSEHKKNHQSDVWRIFQVNKHLSKDGHPWRKFGSGNKESLSQVGKDLKAKGLLNGNGAIKSVDGSLAANPTLSRAASPAPSVSSAISESEGDGGVVGRETRRRLVEWWSKEYCASRMRLCIIGKESLDELSEMAADYFSPIPNRGQEPLPMIPDHPFGPNEMGTLAAVQTVMSFHALEISFPLPHLPPFWKYKPAGFLAHFLGHEGPGSLHSHLKQKGWITGLSAGPQNLARGFAMFKVTLYMTPEGFENYESLVQSVFKYIALLKASEFPPWQQRERSLISATRFRFAEKRRPDDYAVWVSEHMAWPVPRELILSAPQLVEEWDVNDPVNGGESEVREILDSLTIERSRTVLMAKAEEHERVRGKDLTWEKEPWYGTPYRVERFSEEFVQKANQPNDIEELYLPGPNEFIPTNLNVEKREVEKPAKRPFLIRETPLSSLWFKKDDQFWVPKAQVVMDLRTPVACASARATVMTRLFSDLVTDSLTEFAYDADLAGLTYGLSSQSLGLYITLNGYNDKLHVLAKDVLERTRNLKVQPDRLAVMKDQAKREYENSLLGSPFRLSNYYIRYLLSEREWTPDELLAEVTSVTPEELQAYITSLLSKLHIRMAVVGNMYKDEACKLAEMAEDILRSEPLPADQLWNLSLVLPRGSNHVWSAPVPNKNEANNALTYYMSIAKAGDRRRQVLAALVAHILSEPAFNILRTREQLGYIVSASHWHMTGGGQTGLGIIVQSEREPKYLEQRVDAFLGEMREKIASMSDEEFSEHKVALQKQWREAPKNLTEELNRYWPQIEWGYLDFYRRDLDSELIEGVTKEEVLSLFRSAIDPSSTERAKLSVHLKSQKPRPAKISVAAMEAFARKVAEKGYTVDEQAWRDALASDGDAALDKFGSYWRDALLAQAATVPPEVAQSLTAEVPVLLKEYPSGDEGKDDVALDERVAFIQDAKAFRASLPVSERPRPLVEWGDLPTSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE52</accession>
    <name>A0A4Q9QE52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_943570</name>
        <name evidence="2" type="ORF">BD311DRAFT_24645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE52"/>
    <dbReference type="OMA" id="LHTICFV"/>
    <dbReference type="OrthoDB" id="2771214at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU32232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU66112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8941" checksum="37F9385C9816747E" modified="2019-07-31" version="1">MRPLKLYEHPEFKREESDISLLHTICFVLTLALLGATLVLSVSCLLLWDDCKTSYPIYSARPHLLTVRQVLNGSAAVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K0E9</accession>
    <name>A0A4V2K0E9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_919079</name>
        <name evidence="1" type="ORF">BD311DRAFT_758103</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143420">
        <property type="protein sequence ID" value="TBU28623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K0E9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="274" mass="30672" checksum="6E71E02A54309D7F" modified="2019-07-31" version="1">MALAGIGWLALPLVLIRPRRKFALLARQREPSITAIRSARLIDVPSTASGWSSDFPHSWPVNFCLPAGASKRVAAFPALTTARCLPCFLLIAFLRNIFLVVSYVSCDRCSGAEAIFAIHAYGPTSTSRPERPNQLLQWTICPSLLMHLNILRMFFSLLPPAPPRTPSRVKPKALHRPSEVDLDRGFDEALPILTLFRTLHSICQPRRPPTRLNCRHQRPFLPTRWLAAGERAAWNVIYGDQDSPQLMSEYQYPGRRVGGGPSPTNILDVIHEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K1X7</accession>
    <name>A0A4V2K1X7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_811893</name>
        <name evidence="1" type="ORF">BD311DRAFT_650270</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K1X7"/>
    <dbReference type="OrthoDB" id="2751906at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU34483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="21817" checksum="15703FA051BEE390" modified="2019-07-31" version="1">MEQFEGEGGTRIHPLRQVALKWVVGASNLGGMKREARLYEKELAPLQGTVVPRFFGFFRGFIGDVEVGCIVLEWCGGEPIKEMQELNRQRMLAGIALHKAGVHHGELLDKSHWVPVGDGTLRIVGFSSAQTHGCAGMTVLSRNNSGDPRPKAICKELAVLESRFGVDAERTGNHVRWANNLYPEFDAAFYDTYSFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K2V8</accession>
    <name>A0A4V2K2V8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K2V8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="57"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="402" mass="44950" checksum="4A65D468CD117F14" modified="2019-07-31" version="1">MIRRNSSRRPSASSVPFPEHQLDEKYYTMTSTQSTGSRLGVLHDTGIPPGSEDYTTLVVLHGHNWHSGTFSKVIPLASINNTRLILVNRRGYPGSTPFTDEELATIPKLTPDANEDTLEDAREELGLFMRDRAREVYDLLEDIVRQDNIPPAQPEKNTGGIILAGWSFGALWMNALMAYVSSFPVNDVELSKYVRRVVIFDTGNLVMGYPGRSDMYERGFDPALSEAERKAAYNVWERARRISSYYSHGETLDSLSDEPLKHPPSTVSTLSAEERANLTHIPGGVVDSAIALPGIQSGLFDSLRQRAISLPSRQDNKENGDDAESSGDDWRDIELRVVWCQMSHAEVSYVTLLLIAELEDAKKKGIPVRNVRVVRVKGANHFIHWDQPEMAMRALLGDEDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5L7</accession>
    <name>A0A4V2K5L7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_852073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5L7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="169"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="341"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="756" mass="84848" checksum="97BE96A6E45729F6" modified="2019-07-31" version="1">MRLIDTTTGEFRSFNGPLDVPYAILSHTWFLDGEQSYQDILAIQESFRAQRNVIAETLYLADKPPGISHVALRVGAWTWDMILDSISALLFLATHLRHTPPSVLSRVYVNILTILLVSLVHPWEPYTALVLPTLRDSFDADETSVAGDTTHFQHPSISASSILSSPLVCMKLSDACARAREDGYELLWVDSCCIDKSSSAELSEAINSMFEWYSRASICYVYLADVDDDDIVDDPHSQFRRARWHNRGWTLQELIAPRYVVFFSRNWRPLGTKSTLSRVIEAVTGVDRAILNQDRPVHSASVARRMSWAAKRETTRVEDQAYSLLGIFGLHLATNYGEGRNAFVRLQEAILRAIPDQSIFAWGHSCAESLPSVSHLQFLLAPSPAAFASADQVKPLSHEQVAARLRASSRLPLPEYLTTSYGIRTRFPMIPLIGSHLSFFFGSGTYAICAPLDQPVTFTPTHFAILECEDSFGRLVALPLSCANSDENGLTGSESKVEVGWIRVGDTGPLTPFRTVSLSPADLKIVNAPIHLLDVLIRGQPLLEDDVSFVESLSPWSVRTDNSLLSRRIIGLCDWSRNLLIGQGFTVTHMPRLEGMSGILNGTFPRKGLFHRKDDVFLLSSSKEREHILVRLGRNPEAMDVAVYCAHHPRLDVWEAVNGQRRIHALRVEAVNVAWTTFELPTGSNMERHRTLRLSLHNLTRSLRQYGAIREYHFELSIELCYERTSRHSSRKVPVAQSGGHEENNRGQDFEDDGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6R2</accession>
    <name>A0A4V2K6R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_170757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145222">
        <property type="protein sequence ID" value="TBU53183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6R2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="56" mass="5805" checksum="50E56B1A4391F3F4" modified="2019-07-31" version="1">MGVPFCGPMEGGSQISDSVRTGIACPSCSEIFCAGSHPPRGSRCYCDRGASCSMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6T8</accession>
    <name>A0A4V2K6T8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Carbonic anhydrase</fullName>
            <ecNumber evidence="2 8">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_961998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="2 8"/>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6T8"/>
    <dbReference type="STRING" id="114155.A0A4V2K6T8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071244">
        <property type="term" value="P:cellular response to carbon dioxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002:SF76">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU53513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="20100" checksum="06FB5B5E8E2A8F25" modified="2019-07-31" version="1">MTSTFLPSPPSKILSDLLNRNEKWTEANSGLFLQETQSPKVLWIGCADSRVPESVITNFEPGMIFTHRNIANQFHADDDNAISVLIYAVENPKMRVDHIIVVGHTRCGGVEACCKAAQADDSPPANALQRWLAPLTEFARNNGLGGDLSALLEANVRMQVDNVLKSEVLEREWGIRDVHVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7J4</accession>
    <name>A0A4V2K7J4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_823705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7J4"/>
    <dbReference type="STRING" id="114155.A0A4V2K7J4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="455"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="589"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="853"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU56438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="930" mass="97131" checksum="E2EB27F32B2B7AD6" modified="2019-07-31" version="1">MNRRKKGGNNNSLKPPAQAKPPAPSVTTSTTTPATVPAMPMRVSPPLKATTAPPQNVPPPKPAHAAQKVAQQPPKLSASPPKLPVPTMPPTRTAIPAPRPGPSQKRVLTRSDRVRVVWMQFDETWVAPQQATVAQQLEQLLAVAEKNSRVKGKALEQSKDQIVNSMRREFAMAARAEWERRLEKEGLQAEDWADMTPEEMAAVEQVLSCDDVGDGPAVSTIPSPHERAVPIVAARTHVDVPHPIASHPMTSRTTQTPPPAASQKATQAQPPPSAQKGSQSQPAWSAWAAGSRHTSVTEVPEEPPKTTSAWSARPNAPIIEDVRVSPKPVPAPQPPQASQPAPRPAQPAVQAEPTVTSAAPAHGLLAYPVPISLTMAPLDSAATSDAKFVQLVDNAYVNSIKDFHDKAATVDAELARELRKPMSPAEREWTIRAHMMTMEQIARTIVENRDTIIEKERRKRGYGGDGGAPPQPPPSAPKSQTILSQPPGAFPDDGIHVSPVPEPEEEAEIEREPEPDVDEVIEIPLKGKAAKKKGKKAATNGRSTPTPSAPPSAKPAASAMKSAPVVEKPVPVVEKKPVASGWGAKVTAPLRSASPAPPVVPPATLAPINTRLAPTPSPNGRGTLVPPGMSPWEVAKAKAAGTLKPVEPQAKPPSPPNGMWAPPVARAPSNKNQYAPTRPSRLAHVTEPESPEPPSPPPMVEPTGKDYVAWFAGSSSEDEAGLSEDEADDDDDDNDSGAQAGPGGFGGILGALAGASPWALFGSESAPPQKERGRSAHPDRGRAAAATPTPAMAAAGRSGGDLGMGMGAGMSGGWAQWGADPRAGSGGYGAGPSGFGAGSAGFDAGFSGPAGLDSGFGGSARGTAGRQWQRKEEDSLEDMLELASRSLDHATGGQGKGLEEAMAMFVTAQKARETLATPVGGRSANPWGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7W1</accession>
    <name>A0A4V2K7W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_537253</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7W1"/>
    <dbReference type="STRING" id="114155.A0A4V2K7W1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="456" mass="50145" checksum="5544EEB39FA73344" modified="2019-07-31" version="1">MTTKRFRVAICGGGVGGLTCALALSRYHDIQVDVYESAAAFTEIGAGIGLWPRSWKILCALGLADDLTKVAMVPPTEQPRVAFTLRKGDQPEGASFYTLSTPGGLLAFHRPDFHGVVLRHLSSQCRTHTGKRLVSYSHTSSPQPATKLYFRDGTTATCDVLIGADGVKSAVRSALVRELAGIVRAEGKVEEAQRLLAAGAPKWSGTVAYRALIPAEILRQRAPQHQVLNRPMLYLGENSELTVYPIARGTFINFAAFRSRYDLEGSSFDRPWVQDVSQEEVLADFDGWEPEVHALVQSLQKVNRWAIHTTSPLPTFVSGRVALLGDAAHAMMPYQGAGAGQSIEDAYVLATLLGDARTTLATIDRALCAYDAVRRPFAQRVQEASRENGLLYTLNFPGLTFDRPARRSDDEASAKLDEISSRIVTNWQWAWNTTIDGDLNRALRMLDGPMIRKRWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8Z0</accession>
    <name>A0A4V2K8Z0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_149375</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8Z0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="200" mass="21476" checksum="EDB0A9713E7171CD" modified="2019-07-31" version="1">MGRICPFPSPAFVSRIARRASIFASRTHVVYRTLAHLPLYGQSVSVPARCFCPKLPCSPPTFVFPARPAVAPPSHRALVGYLSTTATSPDPRSTATAPSKSDVPVTGPGLTCSPPSSPKTMNRDMAHAPANAPAHYALLAYAQEMHQYTLELWTELSNKLDAQGRPAATPTRDLPRNVYEQLPQGGASPDDTDAESPQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8Z3</accession>
    <name>A0A4V2K8Z3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_812422</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8Z3"/>
    <dbReference type="STRING" id="114155.A0A4V2K8Z3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10540">
        <property type="entry name" value="SET_SpSet7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="36"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="343"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="422"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="59951" checksum="83557C8045747080" modified="2019-07-31" version="1">MSSGSSQDIRGEAIHGTPRSGPGSSLVKTPAHLNSSGLRIEYAEGKGRGVYACREIPAQTLIEISPVLLFSAAEYEEHGRHTVLDHYTFVWRDGHMALALGLGSLFNHSQNPNVSYTIDPSTESINYVTSRRVIPDEELCIFYGHKLWFDPVGTTDTMPADAIEERDDGWGGLSGVADDEDDEVARGANEPFDSFADGDPSQLVPEEALPFKRLKLTPDEEEEGMDSVRTEEAWVVDLPDPRLAATMLKWLKQSGLDTLSMAHLKRIRKVDDKMSMVLILTREHPQPPAFPENIVLPPPYVLTVPKTAALTMTSLKLKSSLWPTIYAPRKRFEPEPWSRGKVRWACEAIKQVIKQAREAGDKGEIPIAAYVPVPYDEETRIATHMYEPISAHDTRTSLCHPLRHSIINLVRDVGELRASTLHPSSTPTLPSTPAFDTTSPPHQLTTAENRSVNGAHYLLTSLTLFTTHEPCIMCSMALLHSRVKEVVYMIPMEKTGGCGSLTCVPRLEGVNHRYVVNVWKDMGKEWVEQNGLEVNDACDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9B2</accession>
    <name>A0A4V2K9B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_916982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9B2"/>
    <dbReference type="STRING" id="114155.A0A4V2K9B2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12411">
        <property type="entry name" value="RRM_ist3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000609">
        <property type="entry name" value="U2 snRNP component IST3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045844">
        <property type="entry name" value="RRM_Ist3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="311" mass="35967" checksum="6281ED8D845875E3" modified="2019-07-31" version="1">MNVVREINKINERELDLGISGSWHDDYKDSAYIFVGGLHRDLTEGDVITIFSQYGEIMDINLPRDKETGKQKGFAFLMYEDQRSTILAVDNLNGAQVLDRTLRVDHVKNYKQPKAKGEDGEWKEAEEQSLNAKPPIVIDGDEGSESSDDSGPEIDPEDPMAEYLIAKRKEEKLAKKGKKSKSKRKHRDETPEERRARKERKRLKKEKGKSAGMAAVEDLLKSLGGGTEPSDRRRSASPRRSRSRTPPAREYVRDRDRYSPGSRNNRSRERSPPRRRSPTPPYRSRHENDDDDRRRHRRDDATLHRTRRGYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9D6</accession>
    <name>A0A4V2K9D6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_916455</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9D6"/>
    <dbReference type="STRING" id="114155.A0A4V2K9D6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="138"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU63478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="371" mass="41767" checksum="1E1AB1FD3438F017" modified="2019-07-31" version="1">MSRNNGAPLLSLHLPAPPRLGVVDDDDIAAGDHLKHKRWYHYLPLLLAIVLILAPHPSLIIVFVKYYYLVHGLVLRPLLHGLAIYTLTFMAFSSLIVVLARDPGPVTDKSQGENADEGEAESFMEALLAPPEDGEVHEPGKWCKKCNAPKPERAHHCGTCGRCVLKMDHHCMWLGHKCIGHRTHASFVHLLICVTSLAVYVAALCGSVTWWAFTHPLNIDETTPVHAMFVAFYAIVICMVIGSFCMYHIYLISTNQTTLESLSPFLLLRHISPLPDNADSRKLSNPPLEHELSFEQRVLVREAHRHIRLYDVGLRKNWAQVFGWSRPWGWVYRLLLGGGCMGDGKTFPRNPRADEMLNRLVSELVSADKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9J6</accession>
    <name>A0A4V2K9J6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enhancer of polycomb-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_807524</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the enhancer of polycomb family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9J6"/>
    <dbReference type="STRING" id="114155.A0A4V2K9J6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Enhancer of polycomb-like N-terminal" evidence="9">
        <location>
            <begin position="15"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="396"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="880"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="880"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="941"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="983" mass="107978" checksum="6F542EA1444212FB" modified="2019-07-31" version="1">MPRATHPGPAALRNRNRVTNKTRLKVIRGDTIEADSIVLDEDEEKARVVSTAGVDAEDANEHHLQAVLTAAASRHQATTRSTRSGDAKDKESAPAAYIPTPDSTGVVQNYDELYPPGRWKDTHSHVRSSDTVEEATSFALANGFIYYMDERDKEWLDKNNEQARGEGMSSQGSVSSSSTRSGRSAKAKGKEPDIVQAVTITEDEFELVMAIFEKVTHEKTEFLHHVSSLPVLELGTRPTPRQAFEQGVPFPPFSDYQDTFAFPLRSDMFAIYSVPEWVPPPQSMLHFARIIYPYWRERRQERGGHRIIPAVNLDESDTKNESYICFRRREIKAIRKTRASQASYSDRMVRLQNELAMALDIVRLVQQREILKRDSHIHGRNLWDKRQTLADLKRAHPSLGSKEDDELFLDKEKPPKKPKVETTRPSLKLRHPPRENGEVGSPVAQPTPVIRPKERCAAIRSAIEAEMQRQKEKDKSWEDAVENPYQSLPVSYDARQFKFPSKEAKPIPRHQLFNEDDENPVKYHVARIRRGRGGRMLLDRRSVNCTLRAANFDKTDVEERERRQRIEERWRYDADDTPPVGPRGMEEQDRKLIDETQPIRLTFTMAHPEDYMTKITIDPTLRLSSGDVKPFQLGPVPNAMLKPPPHPHHQQVVSSVPAASAASSSHSLLGQVNGTPLSVPTQVKLAQMRISSNGGMRMASGSTPNPASHPPSPHATPLPSGATGNPADGQRSPPKPDQDVKMAHGSPSGAPSQLDGVAAPMPSPTPAPSKPLASTGSVNLPNLPNGYHIPAMNGYTTVPKAGFVHPGTRPNGLSIQQIQSLQAMLPADNVNIALRQPGAYVLPNGAYQMPMAAGRPMQWPMAGQHSPPNANVGIDVVASQGAAGSPGRAPPANGMRTPQLSQGRPMPSPQVHNATQGTATPAGPHIARLTPHTPSPHVLSPNLTAAQVNAHSSPTRTPQPAIPNPSPSLQSRQLVGGSGAAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWI0</accession>
    <name>A0A4V6MWI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_448981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWI0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="20254" checksum="8B53FFD06C6B1C7A" modified="2019-07-31" version="1">MSHRERALLPFARSTPRNTTTPAGLVGRMRMRLVSVLSWTHPIPAPAMNFDRDRGGPLCLVWQSGHAEATPWAAILGSQYRTTSLQPTCHIGDRILAPRVQPTPEHIASWPMCAVRHNHTLLRGIEALSTFSSRFYCCLEVPMASTQVPSCSSITVCKARKELRASLHCARLWRTSCSILLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MCM3</accession>
    <name>A0A4Q9MCM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_821860</name>
        <name evidence="16" type="ORF">BD311DRAFT_673865</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="ML143504">
        <property type="protein sequence ID" value="TBU23461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MCM3"/>
    <dbReference type="STRING" id="114155.A0A4Q9MCM3"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
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        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="297"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU23461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU57258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="614" mass="68709" checksum="502B23E54EE29148" modified="2019-07-31" version="1">MVHAPNPDRALRIARNHAYAHQIWWLIASFIALIIIFQFLSWAVSKYYSRNTPKGKKPADAEAGASPIPSPRRFSLRNIPTAIINVYRVVAFRWTLEIGQSYTLNFAEVFITVAYIVALFTWEFVNTTDTQGQKLDISYWGSRAGSLAVTQTPLITALGTKNNVISYITGISYDKLNYIHRMTARVVFVLLWVHGGAKLSHSVPEEFDEWFIRIGLTAIIAFSILILVSLRPIRAEAYEVFYFTHFFMVLIFLLGGYFHAKKVDFATYVWPSFLIWALDRFIRVARVVYYNHLYFGFSSKSDRLDASVELLSPHFVRLHISRPPHFNWTPGQTAFLVMPTVSGNPLEAHPFTIASVDSHYQLTTAEKPDLEKKASSDAVDIAPYWKELVFLINVREGFTKRLAAIAQKGEKVKVLIDGPYGFSPNLDNDDTVVLVAGGSGVTFTLSTFLGVLSHVQNKKSKCRRIVWVWTIREADHIEWVSKALSKALELAPSDLEISIRIYVTGRSASNETALRQVKSWNEDDSIHSSEGTTVGKSRPPSLLNFPAVQVNQGRPDIPALLHDEVDATTGRISVTVCGSQGIARACRKALRVPISTGLNGGPSVVLHVESFGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MLQ2</accession>
    <name>A0A4Q9MLQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_811216</name>
        <name evidence="3" type="ORF">BD311DRAFT_316788</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143420">
        <property type="protein sequence ID" value="TBU28560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MLQ2"/>
    <dbReference type="OrthoDB" id="2626017at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU28560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42570" checksum="B35CBEA2F501C3AF" modified="2019-07-31" version="1">MSDNSTDSGNSTDSGVPDLSDILPPYLNLPPHLSAQKYFFVCTLTVAAWDTLVLSPRTWRLLRTKEWPPLKILFHFLRLFMPVEFTIVGVAFFDTKWSQAQCSHFFLFEPICTAILLAACSIVHVIRIHAIYEKNRNILYSMGGLLAFQVVITAICCGFYRSTPLLDGQGCIAEPKANWVGIYWLSATLTYTASFALAVQRSLRSLKIKPLSYWKLMLRDGLNLYGAIWIVNMVNMLFWFIIKPTGPDDPIRTIVTSMAAVLTASMTMRIILAVRGSLANGGSFAVSSTSNPSRSGNTTHVISASRPAGQPPVNPVLSLRGPTEPAYAVPLDQADKVGADWDGKSSVGGRDQKVTEIYPSDSPIDHTGVQVTVETENDITFEKEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MM05</accession>
    <name>A0A4Q9MM05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fatty acid desaturase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_948084</name>
        <name evidence="9" type="ORF">BD311DRAFT_778254</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143421">
        <property type="protein sequence ID" value="TBU28505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MM05"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021863">
        <property type="entry name" value="FAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11960">
        <property type="entry name" value="DUF3474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase N-terminal" evidence="8">
        <location>
            <begin position="14"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU28505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="52178" checksum="106C6F33B33A3DAF" modified="2019-07-31" version="1">MFKNGPEYEERLARPFVPPTVTLKQIHDAVPKHLLQKDPLRSTGYVVRDVFFCALFFAFGAAIEPLVSSNFLGFVPLTSPWQATLARSLLWLTYWWWQGIAFTSFFCIGRHGKEGCSLCLPQLGHGTMYKSWWANNILGFLLDTFVLAPFFAWKVSHNAHHKAVNSIERDENYVPHLRSHYNLPPKERATTADYAEVFEETPLFTAVRMFVMQAMGWWLYLSCNKLGAKMYPKGTNHFSPYSPLFKDGQRLSIFISDVGLIGMMSLLYLFGQAYGWKALVAYYVIPYILCNHWYDICHPLMVTFLHHSDPTIPHFRKEEWSFLRGAASTVDRPTLGWIGRFFFHNVAHDHVAHHFFSHIPFYHQPAVTDAIKAVLRENYNYDSTNTFYALYRSFTECVFIEDEGSIVFYKNKNGVAARHVAEDAITAIKKEGWTQEDQDKLAEGALSDSTRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MWN2</accession>
    <name>A0A4Q9MWN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_803941</name>
        <name evidence="3" type="ORF">BD311DRAFT_654721</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MWN2"/>
    <dbReference type="STRING" id="114155.A0A4Q9MWN2"/>
    <dbReference type="OMA" id="YELGAHY"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="2">
        <location>
            <begin position="42"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU32419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22816" checksum="E05B409EB8BA4735" modified="2019-07-31" version="1" fragment="single">ARKAAALAEDYAPSDPEADARLQRQQKEEEASIKRVCDELRLQIHEINPDGHCLFSAVADQLALLGIIPEADASYQTCRQAAADFIQTHPNDFLPFLPSEGGEDGGGATDAGIMTPEQFQRYCANMRSTGAWGGEPEILALSRAYRVPIHVVQGGTPPVVVHGEDFTTSDSKHVVYISYHRHMFGLGEHYNSLRPKTFMNTVKSALHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N3J5</accession>
    <name>A0A4Q9N3J5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_700196</name>
        <name evidence="4" type="ORF">BD311DRAFT_802976</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N3J5"/>
    <dbReference type="STRING" id="114155.A0A4Q9N3J5"/>
    <dbReference type="OMA" id="AYMITLN"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046580">
        <property type="term" value="P:negative regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05132">
        <property type="entry name" value="RasGAP_GAPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023152">
        <property type="entry name" value="RasGAP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF17">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00509">
        <property type="entry name" value="RAS_GTPASE_ACTIV_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ras-GAP" evidence="3">
        <location>
            <begin position="168"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="770" mass="88084" checksum="33C9970F5772CE1B" modified="2019-07-31" version="1">MSYSDYPTSPQSPGSMSTRRLTNRNTNRYSVTALFSMAAEQDVEVEDELGRAQKRLRELKSRISAQSKRNFVLERDVRFLDSRIGLLIQNRMALDEQHEVEKHLEEVDPTEGHYPDDRKLQQYSNLFFLLQSEPRHIANLCRLVSLTEIDTLLQTVMFTLYGNQYESREEHLLLTMFQSVLSSQFETATEFGSLLRANTPVSRMMTTYTRRGPGQSYLKSVLAERINSLIEHKDLNLEINPVKVYEQMIQQIEEETGTLPPNLPRGVAPEVAAANADVQAIIAPRLTMLMEIANSFLLTIMESLESVPYGIRWICKQIRSLTRRKYPDATDYAICSLIGGFFFLRFINPAIVTPQAYMLVEGVPAKHPRRTLTLIAKMLQNLANKPSYAKEAYMITLNPFVENNKARINQFLNNLCEVGDFYDTLEMDQYMALSKKDLVINITLNELYNTHSLILQHIEVLSPNDKQHLRILTDELGAAPPQVPRKENRTIELPLYSRWETPVQDILMDSVSPSDMLYMEAKSIFVQLIRSIPGLAEKRPYNLAAIAERAATTKDATLVRKGIKVKEMLRELEEQKIVDRGDGYKLMQDEVSAELVHLGNLREKVLLETKSLEAVYKTICDHNNYLRGQLEQYKAYLQNVRLTASKEKGQSTGVGVVTVGGKEKKPAKPVVHGPYRFTHAQLEKEGIIVESNVPDNRRPNIYFNFTSPTPGTFIIALHYKGREKAILEMDLNIDDLLEKQKDNKHLLDLEYVQLNVPKVLGLLNKIFTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDZ8</accession>
    <name>A0A4Q9NDZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDZ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NDZ8"/>
    <dbReference type="OMA" id="AEKFTIY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="38745" checksum="EB264A9DD2575F20" modified="2019-07-31" version="1">MSALPKAALYYSPNSIWASVPLLALEEKGYGADEVDLKVVDISKGENFEPTYLRLNPGGTVPTLVVPLQKTLSPEIESRYKAIQDTKSIVEFLDKSRSAQSRTHTTSTAPSPSLAPATIAFNAASHEIVDLLHSQAADPNALFYMNARSETELKALATKLIPFLVGRRDALARLLTESDAGNISASDKTRSFWQVKKIATDKFLQVFEEAEKSEGELSDDARQRREEYLKSSHAAWTALKDVLITLNKEIIGPYALGDQLSIADLHLAAWLSRIASLSGATPAEDGTSVLGKIEAHVGDEFTLPKEFSVVEARRRAGLVAGNIEPSERQNKLAAFWDAIKERPSWKKVYGAGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFA1</accession>
    <name>A0A4Q9NFA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_951352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFA1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NFA1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="400" mass="44222" checksum="D30830ECF598BFF1" modified="2019-07-31" version="1">MSPASLTPLRRLDGSHADASLDDTFGAVLLGTFFALMLYGVTLQQAYRYHVLYPSDRLLLKFAVGTLDSVPRDCLNLILYLVMLLQVYATVILETVHMAFSCHTSYYYLVIGFADPSILQHPVHFFAHRAYVFGKRFRVWVSLAILFLMGEFGVHVWIDDNHAHLPVSAGFCVASSLMKAFTPFARISLSDRGFSAFVRYTWIIATASAMAVCADGILTTVLIMALLQGRSSLKRTNSTLDVLVLYTITTGEFVEVRFPSYLTFPLGLLTSVSMLLLFVFVVLRPADLIYTGVSLVSTKLYANMLLAALNSRQSLRDQVNLNIGGTEIFGTHVQQSRTPFDQSVAIELPDISDQPGDDDGFRLSTVEIEDHGSNFSCKDAVDVEARYSPKPEPGSPCHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFC0</accession>
    <name>A0A4Q9NFC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_859065</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFC0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NFC0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="444" mass="48350" checksum="5A3EB2C8074F7EF8" modified="2019-07-31" version="1">MTSKRRSGRSFHPGSPLASFLASSEAGFKSIEARHNQGKEEERRRQAKCTYCQKASGDSLKNCSRCKAARYCDEKCQLADFRARHKRECANFVHPPTTSSFLTTPVAGARYPPQPVFAQGCEDGVGCWVSVTGRIDCDLGALSETVDLAADPQKRQIQMATSGPNNGIDIIRDYKAAAHSILNLSVLVQNRRKEKGAVLVFGSCAQVVSYGSTADIVLRGTAKGDNIVKFTRDRVGYVVAGVAIDPWDKVPRLQITQLNGQEVDGETSPLPHPIKDVKEGTVALDPGDYAILHLQFRVGDGRRVAKDWEAMACIESLHLPYSLWDGTSPPRSLVPSLPLAQTPIPAPTPAEGEPRGRAVTALFNQRAVRAHYADFIEHGEEAYLRSHFGDARADMARNIESMMTMMGEMVLGQVAEAGATDVLVQQLREMGMGDVADKIGARGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NI16</accession>
    <name>A0A4Q9NI16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">L-dopachrome isomerase</fullName>
            <ecNumber evidence="9">5.3.2.1</ecNumber>
            <ecNumber evidence="8">5.3.3.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">L-dopachrome tautomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phenylpyruvate tautomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_940691</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-phenylpyruvate = enol-phenylpyruvate</text>
            <dbReference type="Rhea" id="RHEA:17097"/>
            <dbReference type="ChEBI" id="CHEBI:16815"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="EC" id="5.3.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-dopachrome = 5,6-dihydroxyindole-2-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13041"/>
            <dbReference type="ChEBI" id="CHEBI:16875"/>
            <dbReference type="ChEBI" id="CHEBI:57509"/>
            <dbReference type="EC" id="5.3.3.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.2.1" evidence="9"/>
    <dbReference type="EC" id="5.3.3.12" evidence="8"/>
    <dbReference type="EMBL" id="ML145260">
        <property type="protein sequence ID" value="TBU52230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NI16"/>
    <dbReference type="STRING" id="114155.A0A4Q9NI16"/>
    <dbReference type="OMA" id="YINFFDM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004167">
        <property type="term" value="F:dopachrome isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050178">
        <property type="term" value="F:phenylpyruvate tautomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="entry name" value="Macrophage Migration Inhibitory Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001398">
        <property type="entry name" value="Macrophage_inhib_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954">
        <property type="entry name" value="D-DOPACHROME DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11954:SF6">
        <property type="entry name" value="MACROPHAGE MIGRATION INHIBITORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01187">
        <property type="entry name" value="MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="Tautomerase/MIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0202">Cytokine</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU52230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13167" checksum="5738D448C04485B2" modified="2019-07-31" version="1">MPALEIRTNISVADPKAFVKDFSEFSATTLGKPLAYIAVHLVHDQNLAWAGTFDPAILLNVTSLDNLQPENTEKFSKAFFGYFKEKLGIPDNRGYILFIDPGRANIGHTSTTFATIFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIN7</accession>
    <name>A0A4Q9NIN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Actin-related protein 2/3 complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_933117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ARPC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIN7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIN7"/>
    <dbReference type="OMA" id="GMGCIMR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.190:FF:000003">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.190">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006789">
        <property type="entry name" value="ARPC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036743">
        <property type="entry name" value="ARPC5_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12644">
        <property type="entry name" value="ARP2/3 COMPLEX 16 KD SUBUNIT P16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04699">
        <property type="entry name" value="P16-Arc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039096">
        <property type="entry name" value="p16-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69103">
        <property type="entry name" value="Arp2/3 complex 16 kDa subunit ARPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17046" checksum="12782B11AA515892" modified="2019-07-31" version="1">MEVNFRKIDIDQYDEDALLYNELYDTDPRDPAQALDDTKQNAAAVRGSLARNDYVGALTLVLENAPYGPNVEEAKNLNLQTLVTILNSTKGTDIPGIVKALSADAQDTLMKYLYKGMALPGWGDVSGSVLLGWHEKLTEVAGTGCIVRAMTDRKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJK6</accession>
    <name>A0A4Q9NJK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_817201</name>
        <name evidence="3" type="ORF">BD311DRAFT_672304</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143485">
        <property type="protein sequence ID" value="TBU24213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJK6"/>
    <dbReference type="OMA" id="RQGWRTH"/>
    <dbReference type="OrthoDB" id="809632at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="28"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU24213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="37668" checksum="5C7C17FB36825C86" modified="2019-07-31" version="1">MAPVKNGRYLFNEIPTGYPVPGKTTIYDESETIDLDNVPLNGGVLVKILVLSIDPYMRGRMRSPENKSYVEPFKLGEPLANSGVGVVLRSEAPNVKPGDHLYGFYRFQQYDVITDVKSFRVLENKEGLPWSVYLGVAGMPGETAWYAWQEYAEAKKGDTVFVTTGAGITVIQIAKAAGLKVIGSAGSDEKVEFMKTIGADVVFNYKTTKASDVLEKEGPINIYWDNVGGEQLEAAIEYAAPGARFIECGMISGYNTTDHYHVKNLFKIVTKQLHFHGFIVGFLRHKYVDEFYSSFVGRVARGEIKYKEHKLYGLDKAGEGILDVQSGKNFGKCVIVVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJQ6</accession>
    <name>A0A4Q9NJQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_160345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145216">
        <property type="protein sequence ID" value="TBU53366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJQ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJQ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="576"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="595"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="895"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1077" mass="114824" checksum="84DF0E4970FE6FAD" modified="2019-07-31" version="1">MPTTFASTTQAQEASTTRPQLLVRTTQFLKKVSNFRTNSRKASSFNSSPELATLQRSARSMDLGSKALTKVDVRAHHSSFDQSRDSDEESPSHVSLRASTPSHQIDGIPNTTNPLRPPPPASSATPSLNGHVQRFARPTDVGSKALTQVDVRAQHHSFDQSRDSDEDSPSHVSLWGSSRPNRTSSSTPDFSAGAPLRQIEGIPHTTNPLRPPISANELPSERSQMLPSRSPPPASTATVPSANGHVQRPARSTDLGSKAPESPPLRQIDGVPHTTRLPISANELTPLTSVHERSQTLPSASSATAPTVNGHVQAYSTLNPSARRALAPRLATLPPPLMAQYTAGGSARLTPSLVTRQPPMPLMNLPTLPPASPSQPPRQTRRNAPLRSLPALPMRGPGDADGDADHENASLEEEDEEEDEHAGSAEHEHEHEPDSDDSSNEDDTSPLPSSSSLAGPSRLPSLPGVDTSAFRVSFGGADATARATSSIDYFTSKPPESGYGPSERTPRPSDFDLRAPGNGKARAVPDRAGGGGILVPQPRIVAMPLATPGSPARPNLYHHASKSMVDLMSLARKDKDTIISPKLGRTPPKTAQGLVSPKSASPAVPAATVPTAVDADKEESAPPPPAPPPESPDDVITSPMLRRRRSLPVYEPSSDPPPYPDPLFRRRPAQAYAYAPPPEEEGTEPLPPYTNAIFLAGAMPRKMEFTAPGVQAKDRKWRRVYCVLEGTAFRVYKAPPAASRVGALEQWWESKVGAGDSTSVDSSAVTASGIRVSAVRERRERERERERAGEAGAEERIPKIPEETTPTGAEQPPSSASANGQQETELPSTKSRLALTSRFLRRQRSKSSTRPLAANSTPPRMSMDSRVSDPAARHPSHTAGRHSMDTLGSARPSIATSASGSTSTSAVPSVPASASASMSGSGSGSASGSSVPTSMSESASRFSRRSFLPHSSSSTSSAGGGGGKDKEREKEKEEVYVPDAKDLIKQYTLQHAESGLASDYVKRKNVIRVRMMGEQFLLQAKDVAAVVDWIEGIQMGTNVALDLDERPMPRGPIFPRCLQIVIVVRVALLTVVAVLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNW0</accession>
    <name>A0A4Q9NNW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Selenoprotein O</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_870526</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SELO family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNW0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNW0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070733">
        <property type="term" value="F:AMPylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003846">
        <property type="entry name" value="SelO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32057:SF14">
        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02696">
        <property type="entry name" value="SelO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU63059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="755" mass="83714" checksum="9871BF4BE70DD681" modified="2019-07-31" version="1">MPLRTTFATFRSMSHTSTPAQASASAVKRVPISGLPLPPPPHSLIHALTPDPYTPTPAEWHNIRAEKPSLQRRARLLTPSAHFSYVAPCPLPFPFRVEYPKEAEEPQEGEDAEAQGKAQVAAVERWLVEREALREVPRAAKEGQGRLRKYVAEKRDEERVLIGLAETGLRDCLPHLDVGDAFELLGAPSLTVPAGQGTDGGAGEGTSAAAVAARQELVDVLSGNAVLMNGEGKVGDQWAPWSLRYSGHQFGNWAGQLGDGRAISLLATPHPDDPRTTYELQLKGAGRTPFSRMADGLAVLRSSIREFLCSEAMHALGIPTTRALSLIHLPKLPVERERIESACVLTRVAPSFIRIGSFEALNPPAQMYFLGGGQQAADLDALRVLGEWVARHVLALPDVKWRGDEGAEGPGDAWGTKLVLEVARRNAKMVAGWQAYGFMHGVINTDNVSILGLTIDYGPYAFMDVFDPWHICNHSDQEGRYAYKYQPAMIIYALRALLNALAPLIGAEDELGGKAVSPGWADDASKDQAKEWSKRGTELVKDEMERVMEEACAVEYGRLMHRRLGLRRIDKDDESKFARPLLSLMEDHSLDFHRTFRRLCFFTPSVVASEESLKAFIDSLLELSSEPERLDRIRGHSDWSEWLRKYAARIESERDHWDGEGDVDAAREREAKSANPRFVLRQWLLEEVIKKVETDTESGKRVLGKVLHMACNPYEPWGAEGVEDESGLDAETKEERRYCGMGERKLLGFQCSCSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQP3</accession>
    <name>A0A4Q9NQP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQP3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NQP3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="716" mass="79530" checksum="648C351F66F067AC" modified="2019-07-31" version="1">MATLQYPNFPRANVLVIGSDTVHALLPSTLISQADALLLAHRLEDVADLVEQQRKKLQSMLNVERHDLDELRYVNQLLGFQCFTETLFEDAGNRLYEGELDPRVLISYYPELRGDLFAEDDTVDIMAGVAEHMPQEDSVDDIIRNYSPHLHPNTREAPPAVELRAILSMTARDMLEAFLRKWRRKLAVEAATPNVEVLRTVVDTVLAKLHVSAGKLPDLHGLIDQPNSVLLSEIAPVLVESRHIGVLTKLYRQHSDDAKLLDAWAKLVDGEWMDAEVQDPLTRIFDLLSEKKDRALIQRWIPWLIKKDSERALKLLLSTMSAKRKAEDDRALLQQIREASPAAGAQLLEHLVIQRRSTDPELHSQLAAAYADQLLSCLADDSILKLWRAKAASYTSSRNETPFISYFSTTTPDSESKRTRLKTILFLQGSTLYDPAAIRSRLDAHAKILKLELAVLEGKLGNHRSALSILVHDLNDSTSAEAYCTLGGEVVPAKTAQQIGERSNLQPWAALVAPLASPGKQGQGQAKGAPQLKKTKTVDEEVKKDLVMTLLEVYMSGGEATADRTAKLLNSQAMNLDVLDVIGKIPPEWSLRILSTFITRSFRRTLHGRHEGQIVKAISQGQNLAVREHAWLILREEGAVVEEPASDDEGQEEGEVEVEEKKLGLELGERVEGQPASFNEKLGLQLSENGEDAEESVVDISVSPQSHPTVGYDVGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR35</accession>
    <name>A0A4Q9NR35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dihydroxyacetone kinase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_935309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR35"/>
    <dbReference type="STRING" id="114155.A0A4Q9NR35"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF14">
        <property type="entry name" value="DIHYDROXYACETONE KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU54692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="600" mass="63353" checksum="ACBC759923584DA7" modified="2019-07-31" version="1">MSSQSKHFLNDPETLVVDSLQGLCTLNPQLGLDKENKVVYVANQDRSKVALICGGGSGHEPSHAGFVGDGILTAAVCGSIFASPNPAQVRRAIDLTENDKGTVIIVKNYTGDILNFGLVREQYSAQHPQKADKVKFVIVGDDVAVGRTQGKIVGRRGLAGTCIVYKIAGALAKRGASLDEVHDTAQWVSSHVGTIGVGLEHCHVPGTAAPESHLGLDEIEIGMGIHNEPGHRRLSPVPPLNELLPQLVEFLTSTTDAERSFLPFKNDGSDRVVLLVNNLGGVSELELASIAGEARKALGAKGVKVERLISGTFMTSLNMPGFSITTLLLPASSESGKGTPDSSLLLSLLDEPAITPGWKWSSNSVPPETDKIPSGTKHEEAVTAVQDGVTIRAEDPKAFDAAVERACKALGEAEPEITRYDNIAGDGDCGLTLKAGAAAVLKDLKEGRITGEHVPKSVFAVAKVAEEQMGGTSGAIYSIFFSALALGLQAQHSQSQTITPEIWSSALSFALDKLYTYTRARPPSRTLVDPLAAFIETLASGKGSNTAEAVKAAADAALKTRDLEAKAGRSAYVEGDRLKQERIPDPGAWGVKVVLENLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NT74</accession>
    <name>A0A4Q9NT74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_930743</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NT74"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="32"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="163"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="369"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU56775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="521" mass="57498" checksum="5AEA0305C8718781" modified="2019-07-31" version="1">MSRILLRNIALVLALGSGALASIGPVTDLVIANKDISPDGSTRPAVLAGGTFPGPLIKGNKGDNFRINVIDKLENETMLTATSIHWHGLFQHTTNWADGPAFVTQCPITKDHSFLYNFNVPDQAGTFWYHSHLMTQYCDGLRGPLVVYDPHDPHKYLYDVDNDDTVITLADWYHQAAVTVQTGVPLPDSTLFNGLGRYIENPTSELAVINVEHGKRYRFRLVNIACDPNYNFTIDNHSFTVIEADGENTQPQEADSLVIFSAQRYSIVVDANQAIDNYWIRAIPDVYHTGGNTTVNGINSAILRYKGAHKREPNTTQTPSLRPLAETDLHPLSNPAAPGKNHTGGVDYALNLHLNFTGTNFTINSVPFVPPELPVLLQILDGNKSAQSLLPKGSVYNLPPRSSIELSFTIDEHLVGDPHPFHLHGHSFSVVRSAGNDTYNYANPVRRDVVSTGGPGDNVTIRFRTDNPGPWFLHCHIDWHLQAGFAIVFAEDSDDVPAVDPVPEAWRELCPTFYAGNETHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUW8</accession>
    <name>A0A4Q9NUW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_818152</name>
        <name evidence="5" type="ORF">BD311DRAFT_660029</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143409">
        <property type="protein sequence ID" value="TBU30014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUW8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NUW8"/>
    <dbReference type="OMA" id="TEKWHSR"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU30014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40919" checksum="9713C88D3EA1665E" modified="2019-07-31" version="1">MDFDLAGLEVDHRKRRRNRTTQSCLNCHTSKRKCDRKRPCQRCIQLGLTGLCVYEVDDPALRDDPNVDENTRLRNRIAELESLVRELRGKPHPKWAEPTFCDGDPNEKWHSRSSRRLQYQKGPRDRHEEANGRMPPAIKTEHGSDPSQQHLYRFTPSPTHPNVDNGSGHSYNLYRNQQGHGHGQAVYSPADDSSCYSSPSSASVMTYGEARHGVSNGDHYYQDQQQQYMQHSCPCLTNPAAGNVLIGLTNQLQNTAAVLRQLPEHNTSRSCVILRRVADLNDIMHGNTSGSPSSYESLSTPTETELNMSPISTSSQSSIGAATGPSMHEQWPSAQMGQSAGYDSYFPVAAATQPEHAAAVYHKTYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVJ2</accession>
    <name>A0A4Q9NVJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_197279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVJ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9779" checksum="C9E97A0E5120C367" modified="2019-07-31" version="1">MECRLRHPRPCRRKGPPTDEKFFGASRNFISAQEEAARRQRKRSREVTQVTERGVTGVDPPDVQEPGCFRFFASDSGSERLVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1H4</accession>
    <name>A0A4Q9P1H4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_806817</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1H4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="791" mass="87912" checksum="79E0867F5FE9266A" modified="2019-07-31" version="1">MSRERRASFHDIRPPHHEIEELEQVQRYEDFTTIDWIQDSIIERNRRLRAARSRNTPYRGPRGEVSLAWIWSQLQTLAHAGQSWFVVSLVGIAIGVNAAVISIATEWLSDIKMGYCSDGWWLNQQFCCWEIEGTDEDTCEAWHQWSEVMPARWAIYVLFAAAFSFIAAHLVKSLAKYAAGSGISEIKCIIAGFVMKGFLGFWTFFIKSITLPLVIASGLSVGKEGPSVHVACCVGNIIASMFKDFSRSQVKMREILTASSAAGVAVAFGSPIGGVLFSIEEMSSVFSIKTMWRSFFCALVATVTLSAMNPYRSGKLVLFQVTYDRDWHFFEIMFFIILGIFGGLYGAFIVKFNLQVAALRKRYLKNHAIAEAVALATITAMIGWFNHFMRIDMTESMAILFRECDGASDYDHLCQTAYQWQMANSLFLATVVRLGLVVISYGCKVPAGIFVPSMAIGATFGRMVGIMVKAVNRAYPNSGIFAVCQPDVPCITPGTYALLGAAAALSGVMRLTVTVVVIMFELTGALTYILPTMIVLLVTKAVGDFLGTTGIADEMIRFNGYPFLEKDDHAYNVPVSRVMRRDLKTLPVSGLTCKDLEEVLSRTNVKGFPIVSADSKNILMGFIDRTQLRYILEKAQNLQDVRPDTPVSFAPNAEDLEEAEFAGVAAAPAVGLDEETSLGLMESTATQDVLKLWPWVNQTPLTVSPQLPLEIAMQLFKRMGPRIILVEGQGALVGLLTVKDVLRFTMLEQHQVQYSPWSGEDFDGLVDEARTLTSNFADDVLSWGRRIFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2C4</accession>
    <name>A0A4Q9P2C4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">4'-phosphopantetheinyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_850697</name>
        <name evidence="9" type="ORF">BD311DRAFT_715412</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2C4"/>
    <dbReference type="STRING" id="114155.A0A4Q9P2C4"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="8">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU32074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU58789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="129" mass="14655" checksum="AD3563D5133D8A9D" modified="2019-07-31" version="1">MGILGIGVDLLHVPRIVRLIDGKTADRFARRILSEKEHLAWNAIPLADHARRAKYLAVRWSIKEAAYKAVFPLRPTWKNFTYHSLSADGQRKPWLEYHSDAPGRNLGKIHASVSHDADYVYTTVLVEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3Q8</accession>
    <name>A0A4Q9P3Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase pc-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_915365</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3Q8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="596" mass="68229" checksum="368500472C32F6C7" modified="2019-07-31" version="1">MSRKPSLPPGVPFLFKLLLVVSAPPFAVYALARVATSQDVVLPTWAWILAGILSGPLALTARVWWKYSSFRRGAERLGAVMPPEMVGHWIGNLDLLTRILDAFENGYPSDMFDVGFGECGPILRFSLFWDMQYSTKDPNIVKTVLATDFNNYEKGEMFHDFTDSLFGTGVFNADGDMWKFHRSMSRPFFSRERISDFDLFDRHADVALGKIRERVQANIAFDFQELIARFTLDSATEFLFGNCVHSLHSPMPYPKGMSPYNIVDEPKSIKEKFPHAFAMAQRIVSERPRVGWLWPLKELFKSRTDEHMAIVDAFLEPLLQEAIRKKEEREKAGASLDDKESQDDETLLDNLVKQTSDYKILHDETLNILLAGRDTTAAALTFGVYLLCQHPHVLKRLREEIVEHVGYQRRPTYDDVRNMKYLRAFLNETLRLYPSVPFDIRFSIKEGTLPNPDPTGKPIYIPPKTAISYSIFNMHRDPVYWGPTAQEFDPDRFLDERVGKYLVPNPFIFLPFNAGPRICLGQQFAYNEMSFFMIRLLQNFSSMELDLTAQPQDSRPPPEWATEGEGRKAKEQIAPKSHFTLYANGGCWVKMGVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P514</accession>
    <name>A0A4Q9P514_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="10">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_512221</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="10"/>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P514"/>
    <dbReference type="STRING" id="114155.A0A4Q9P514"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF18">
        <property type="entry name" value="ENDOGLUCANASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 10" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="7 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0964">Secreted</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="11">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU57797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="25788" checksum="F306F125107C6173" modified="2019-07-31" version="1">MSKLLIIVTAALFAGTASAHTIFQKLYVNGADQGELTGIRAPDYDGPITDVTSNDIICNGGVNPYHQPVSQAVINVPAGATVTAEWHHVLNQAAGDSADPIDSSHKGPVISYLAKVPDATQSTVTGLQWFKIYEDGLTASTGQWAVDRLIANKGKVSFTIPSCIESGQYLLRHEIIALHGASSYPGAQFYMECAQLNIVGGSGAKSPATVSFPGAYKGSDPGITVNIYYPPLTNYTIPGPAVFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P733</accession>
    <name>A0A4Q9P733_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_925678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P733"/>
    <dbReference type="STRING" id="114155.A0A4Q9P733"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039779">
        <property type="entry name" value="RFX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057321">
        <property type="entry name" value="RFX1-4/6/8-like_BCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619">
        <property type="entry name" value="RFX TRANSCRIPTION FACTOR FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12619:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25340">
        <property type="entry name" value="BCD_RFX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02257">
        <property type="entry name" value="RFX_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="847"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="854"/>
            <end position="864"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="876" mass="94810" checksum="7B01B27F2308F22C" modified="2019-07-31" version="1">MAAVNLQMMAANVPFDFLPNAHLHSRSNSVSSSSSHSPGSRPQSSQGGGVLRTTAVLPPSAEDLYRASFHTTNTFDHARNTSDASLSSAYSLDLATPADSPPNHNITNPALKGHLRQTHIRARVSASPYPRDTESVHSSSSETEDISMYLATAGSEYHTMFAGPPQTMMPNPAEAMHAYGRMALSPDHALEKLAANVRAATTTSASDRAKQIFVQAWLTANYSPYPDGNVPRQGLYFSYRRVCDQYGIPHINTATLGKAIRLCFPTIKTRRLGVRGNSKYHYCGIRPATSAEAEFLQDYIRKSNNNAAQQAVNAARMSNEQGENRGGSDEDDEDESEGPASGPASKRNSLNLSSGGAKAPTMFADEKTPTAASLLSQAQATQRPTSAFPVQAPIRRHAGQEGLQVQQPSPSGSVSSSLAMMSGGTAASVRQMPSFPSIDEAVGVNSTTPQSIAAREVWTWFQDHSDALLESVRAFRFDQFEMHLRTFWSSLTGAHREVVHAPAVAGLMAKADAIVYDEILEMLRSQMLSPIAPASLAGLRQLADKMEKILLVALDSYGNTFVEPKVELGARFGHLVLRFLDIYQVTQALNTVLTNQKQLLEMRRSWQKIDFESVRNQSALVCNCRHEDLVQLLEGEFVQVLEGLSKSQDPVRDVMAWADKCCERLMGGRGGGVEERTTMSSRSVLIRWGYVTSQVMRDLTIRSDPAFGAFQILKLFLDDWIALNVLRNVALSTNSVAASVEPVMQQQFFSLSPMPGQESFSNTTLDVRPAGVMANTPTTSSMLAALQADTFSAGTLDPSATTFGADTFGSLSYLDNTSTPEDALSVHNSGLSFPDYSSTFDVPAFTPQDLGISASGTPPSASSDPENESESVKSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P764</accession>
    <name>A0A4Q9P764_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_903779</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P764"/>
    <dbReference type="STRING" id="114155.A0A4Q9P764"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="673"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="760"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="887" mass="93473" checksum="396927803623DE98" modified="2019-07-31" version="1">MEVSNRLNPVWQLETKSWGNEPLRRIYHTACESGGKVYLIGGEKTDGSGNAFSDHYVFDPSASSFTQLPTTNGPPDLFGHASVVLADRRLLVFGGYSPSENSLMAFSTVWTLDTSSSNYTWTATNVANTTLPSPRRGFAAAILDDGKVLIQGGADADMQNVYSDGWVLDTTQSPMSWTAVDALTQVGPRRDHFAVAVGSEVIFGFGYGASAPANASLLLFDASQGAFVSSYTPTPAVTSPSTTTLPAASGTSLPSVTAGGSTGTQGSSSTSSGQSGSGGKGGSNGNGNGNGNGNGNGNGSGSGGGNDSGKSSKSHSAAVAAGIVAGVLGLVAGGAAALYLSRRRPSNSSFHRLGASHDDDDSPHMGPVIPVVGHAGSREKPLGVQNVKQKLAGLVPGRAARQQTARRDMLADEDTMVFEPTWLDVRRDGSIGSWSSGGRRVRPSLGDMVQGSLTSLKNVGGAMLAYASGTRRTRDTSGDSNATYWEKEPSYGYSDKGHSDKIAFVPLAPGAASRPKGGRQASDVSQWTYYEDPFADYDVESFKMPDEDYDDDAVEIHGAPFLNDPPPKPYLYSRVAKATDDVSRLTPVSEKPSFATVTDHIIPSSSSDSSHGALLTPPASADNSRSSHEALTSPRRPSSIIDANPPLASTMRRSDSWWSRFTKTPLLDRAFSADASRSRSLHPLEFRDPNPPPRLNPIKESSNSSSPQDESSKRDHRDDPMYASIHHGRSATSLQTSKTADSAEIEKMGRTMDIVYKGIHSSHGSHNSRGSTSTTSSYEPAADPHEPKPLSVIIPTDTDNLDRSSPPGLGFVMSPTATTTTDVQQPTRARRSSGNVAARIAAFEEHGRSPPAPPQGRSKKTQSVYGLAPKPSLFVANPDRRTGSGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7U5</accession>
    <name>A0A4Q9P7U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_974619</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7U5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7U5"/>
    <dbReference type="OMA" id="FFRCDPC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="96"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="677"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="695"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="716"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="726" mass="80691" checksum="79A4213DDC1450AB" modified="2019-07-31" version="1">MPKAPPTSARPALRRNQACLSCRKRKLKCDASRPHCGTCVKQWQSLISVPPPVGYAHPTEPQCSYDPVEGLPMAANVDPTERIRLLEEQISQLKSQLNDQRNFDSRSASPSRHAHARNHFTTSSSYGGQSDSSSPAAGGIVLPHVSLDVLQDLSPRSSGSHPRGSTGSPELRQGTHHNQAVPDPLMDVLFSGWDPDLPDPDTLDHYIDVFFNCDPCGSRVLHRPSFLASMHLHPKDDNYPHPAILHAICASASRWTSQDIVTLPDGTRRDKFAELHVSKTRAYIDRTMATGVDIFAVMQACIILSWYFYQEGRWVEVWIFAGFQTRAAVPLRLNYPGTFSAIGAASPGAYLAPPRDFKDLESRRRTWWMTIMFDRIASVGGWVHGVDERDIGTELPLRRVDFETDANVPHNPQDLFSEDMFTQHPPQYTDSFILFLKGVMMFGRVTDYNTRSNLRANIPPSKNQNPFALPGFEELDRLVAQDFLQSFPQEFKHLGVTDDGSSLDTDLYMAHVVPHAAIITLHNPYLNFSDPRSVSTSRCLNATRAILAAYYRLSETSLDITRLHPFVTICWYLAAVVQTQLCKYFIEIGDTAREQTVWGEINALRFAMLTYGSRSPIGTRQEKLLQGLMTEIVRMTSQMQPLEVGVPLYPFSHAGVFAKGTLAPDPTAAPLPDVMQYPEASESPTGLAGMTGNITSASSPSSLASWTSPTIRSRPYSHSVSTGFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9A0</accession>
    <name>A0A4Q9P9A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_942871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145536">
        <property type="protein sequence ID" value="TBU50958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9A0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13458" checksum="75B8375E8E5D7152" modified="2019-07-31" version="1">MCTSMFNASTKLPAPSKGHSTRCMRLNALPRPTPGLRTAITSIKPHRVRSVIRVLVTSSVARPRQTSPDPDADPFKASMSDSISAGGRCFTVRDVSASSCPNTRSQCPNNPGPPWAVSSMSSDSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9U8</accession>
    <name>A0A4Q9P9U8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1005769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145322">
        <property type="protein sequence ID" value="TBU51439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9U8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9U8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="150"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="348" mass="38624" checksum="2449B0D318C0DCC4" modified="2019-07-31" version="1" fragment="single">LSIIDTPSLDFREGHELKLERQVSTIVKYLDLQFADTLTKVHGYLGSSVHRVASPPSRCDRALMYPPGTCHSLQESKVVHQSKGDQHIHLCIYMINPSSVLTEGARRAQSSYPTKVHSEVTVSYKPPDLSFMSDDTNSEDEENENGLTTSTADIRVMCRIAVHANVLPVIARADSLMDAKLAAVKKVVRRDLAADLDFGVFGPIVADDAAKSPADERANGNWNGHGHTHGTSHGSQRSADDAAQAHSDSSRPAGGTPEPSQENEKSQKEDTNDADQQQQQQQQQQQQENDNGEWPIIKLQPMWLARRPSRSWSRLWISETMLADDPHALELSTTRRASRAWTSWRTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA96</accession>
    <name>A0A4Q9PA96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_910584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145306">
        <property type="protein sequence ID" value="TBU51574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA96"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020274765" evidence="2">
        <location>
            <begin position="23"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="387" mass="41729" checksum="C4B3CE59730F77E1" modified="2019-07-31" version="1">MRFTPAMISVAIAIGAMSVGRAFATADPGQLEARQSTRCITPLVACTTNTTCASCATFPPVIPSWTCRTVPGSSQGANSSLSIWSDGAGGVQRTQAISLERAQRRNGSWDTAPERNAPLFFEDLTAEVPAAAKLLNGVEGPSRLCSYLQGAVLGVVLAMLWTSFLDDTQDPSAPRVNDRSSRKRRKVDAVGPPLAMLPNTYNDDDAQPGCNFSATMSLRILHCAGSSDSSKKEGVSGGSVSGTVMLAFGRSDAVLRLYCTGQGHSFHPDNIHRHSDTSRDLKSSSSRRTLHLKRESRFTVSGYRLDPSQRQSRELLFDIERYARLIGRTIRTGPGYGWDIVSLCGRSNCTAQNWLDLGAARISYLRILSHVPQDAVHPLLAGLASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAP7</accession>
    <name>A0A4Q9PAP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="5">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_911262</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="5"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAP7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAP7"/>
    <dbReference type="OMA" id="WPDKVID"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="803" mass="87909" checksum="FBF4E157F608DD85" modified="2019-07-31" version="1">MPMLADPSIKYKPYTPLNLPDRQWPAKINRAPPIWLSTDLRDGNQALANPMTIPQKMSFFETLVKCGFKEIEVSYPAASDTDFNFVRMLIEENRVPDDVWLQVLTPAREDLIKRTVDAVAGSKRAIIHMYNATSCLFRTVVFRNSKEETLALAVKHTEIIRKLTEECTAKYGTQFRYEYSPETFSQTEPEFALEVCEAVKKAWGKAGTAYDERIIFNLPATVEIGPPNHYADLVEHFSRNISEREKIFISLHPHNDRGTGIAAAELGQMAGADRVEGCLFGNGERTGNVDLVNLALNLYTQGVHPKVDFSDIQAVIDVVTACNDLPVHPRHPYAGELVFTAFSGSHQDAIKKGFEAQRARHAKARAQGEPEHWEMPYLPIDPADLGSTYEAVIRVNAQSGKGGIAYLVQQHLGLDMPRKLQVAFYAVIQEIADREAREMTVEDITTAFRKTFHLGGSAYEGRLNLKSFRISAEPAAGGVDGEAVDERRQFDGTVSVDGQLRVLRGDGNGPLSALLDALRTHLQIDLSLREYSEHTIGQDQNAKAASFVELVPNSGDVKETRASTESYWGVGIDADIAGSGLRAVLSAANNAIGDRPLPELKLSVGFNARSGQADIATAILNSLKLELPRRLQASFFEAVQRAAHGSGGEISYDALVGLFRERYGYYDEEENPRFAVKSFKLEHLNASGRAKLSGEFIINGKPVSLEGEGNGPLSAAVEAVNRGLDGKVSIREYAEHSIGEGSEVKAASYVEVAYEGPGGSPKWTTWGVAIDSDITASGLKAVLAATKAVELADEEARRTAGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBI4</accession>
    <name>A0A4Q9PBI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_910296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145268">
        <property type="protein sequence ID" value="TBU52069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBI4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54312" checksum="C84B742450F3911F" modified="2019-07-31" version="1">MTSIWTTLPPNIDSLDTLPQGGGSWTDSSQLKASVPFDVAMLILEQIQDITTLIALSSTNQQLRNHGLLLALALCPGALVLASKAAIASFFAFVTHSGRVAIDDSRRLQSVTGLDIAMSTFDLDTLRMLSAMVAKAPKLTELTLRQPEEALKNVSLRHTLKRITTLRALRVFGAGPRAHELFSAIRSPLEEATITPRRDVVRDEDAVDFSKILRRHKYTLVHVSAARSMATAPTTPAKTFFGVRKLHVPLFVHDAHDDFVWAFPDIVELDVGNSSTAWSPRLRDIRKVNKMATKWAREEHDAWWRLEVARGDLFSLYMMGNTCVANALELVGVVHDRSGCLASVIKDHVPRVLRLSISPFLNVDALRGRREALTSVSYLALRIVLESDIEDACGPVVCSSVHFAQAFENCKAIYVDVAGGKEEAARLEVEHALLAACLFNGRVKDVCIRTPSCATFWRFGLTPGGVRVHGVSFDDGKRFFENLGLFSPEYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBW3</accession>
    <name>A0A4Q9PBW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_942089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145315">
        <property type="protein sequence ID" value="TBU51495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6202" checksum="051F4C82BC90AB63" modified="2019-07-31" version="1">MHRLPNSDITNARRPDRLKNLSCNRPVETWGGRFPSTESLQNHLSNRPPKRHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC50</accession>
    <name>A0A4Q9PC50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_241339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145254">
        <property type="protein sequence ID" value="TBU52364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC50"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="225" mass="23727" checksum="2DC8BA7D86F3F442" modified="2019-07-31" version="1">MGGGDGGYRNNDVIRVPLQIRMRIRYGRIPRMARAGTGGNVAIGTALWMMLYIRATRGTVRLLHTTTAIRPEIIGERDADADADAEAQAPAPGICELYRWRGCRETHAQGASLLLRSNASSRRVTQAVHGLAAGGRSGVWLALWASSNPSAEGGSNGSTGGMRTGMNAAHAGGLIPGAIDGERAVGLLDRAGTLDADARQVVGIRYRGHAWRVACDGPGKQYRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEK3</accession>
    <name>A0A4Q9PEK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival Motor Neuron Gemin2-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_982397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145294">
        <property type="protein sequence ID" value="TBU51677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEK3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEK3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22852">
        <property type="entry name" value="SMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22851">
        <property type="entry name" value="SMN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047313">
        <property type="entry name" value="SMN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049481">
        <property type="entry name" value="SMN_G2-BD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20636">
        <property type="entry name" value="SMN_G2-BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival Motor Neuron Gemin2-binding" evidence="2">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="290" mass="31737" checksum="BF6225D354E8BCEC" modified="2019-07-31" version="1">MRPIISYDDITTPQPALPPPPPNPKHQANSSNPQPPAKKRKTGPNQRQRGAANGRVGQPVQHWDDPGNQGMQMSYDDAPRQTEVRGEEEEEWDEEEESRELSHDEIWDDSALIDAWNSAAAEYEAFHGPGKSWKQEPVKKSPLSWYNVPPEKTSKGKLKAAPSKTNGIAVEAEMNGRTEAADSSPLNFDTFVPTHDPSLAPAGPSLSVPAINAATLGSGAEAAIVSQDEAFSNAMTAMYWSGYWTAVYHCRRNESAPQNGAAEEYAADQIEDGLEEGEEDDDEDMLPAQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF68</accession>
    <name>A0A4Q9PF68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_952090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="ML145214">
        <property type="protein sequence ID" value="TBU53438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF68"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF68"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU53438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="485" mass="53326" checksum="3B80A88125B3B85A" modified="2019-07-31" version="1">MMYHAESFASNKFLTYLVGYGGSQPIPSLLAAPNVSIIHLTDPPQSLRKLPFFIGGPLKVLRQILEIVYTLAVHVPDPPEFILVQNPPSIPTLAIVWLVSKMRGCKVIIDWHNLGFSILALRLGNEHPFVTIAKWFESYFGRSAYAHLFVTTAMHDYLVREWDLQGLKVVLHDRPPSRFHRADPSETHELFQRLSPVLTDPLSGLTSFLPNTSPPYSTPFTHIPPTSLSSSGAACLELGPYVDDIAMPSLRPDRPALIVSSTSWTPDEDFGMLLAALKEYDRRARTSEEKGEGVGLPKVLAIVTGKGPLKEKYMQEVQRLQAGHGGGEDGETGPWRFVRCVSLWLEADDYPLLLGSADIGISLHSSSSALDLPMKVVDMFGCGLPVCALGFDCLDELVKDGVNGLVFHNAEQLAAQIESLLRGFPSAPALAALRASFDRGTSAAASRGRGREVRAEEWQWGTWAENWDHVMRPVLLADVASEAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH02</accession>
    <name>A0A4Q9PH02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_952594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145241">
        <property type="protein sequence ID" value="TBU52682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH02"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="7118" checksum="333FEE7E3CE75CC9" modified="2019-07-31" version="1">MTLFGPGLGEPLGIGLDWWQLELRVAQASVLRHRVTSSPRWRRVQTHIERLRFGDVQFYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH46</accession>
    <name>A0A4Q9PH46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_888780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH46"/>
    <dbReference type="STRING" id="114155.A0A4Q9PH46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="70045" checksum="5BF92E8A2566C09D" modified="2019-07-31" version="1">MPEVEYIFVYPHRQAFNTFPVTAADTVRLGSLWDRVQAFEPSLVDHRAGCKFYIPFKLSYEPETTLLSRSRQWLLQHREDKDKQITLGKRVSTIFPDGPSPDEVHFIIATNEVLESLDELGTVEERALRGREQRVEVIRTAVPRPSYGVSTSAGVRKVVVDNADRFHAGRPAGNYGPPACLFNHALGRLDYRLRHLDDDISESAPPPILMRMVHELMTTAARCYSSEDDRVEAIKTLLGEIFSKALHWKPPRGTYGIVPDAINADNPPFVVVDVKNEAGLEGDASLQAGLSYTHIVTAPQFKALRRQTNYPAILCGFMGNLLEISVAIYTDGMYCDLLFSERLHLGFYSARNVLRLSRALTATRKAIADLTAFYAQLKAAPRAPPQTSIAHLFPSPLKIPSYTGFVPSLTFTHRLTRSGEAVLLAASEGERRSGIYLATMPWRSSNVDEETTVSSSSRDAPTDNVEVVVKFTERYHQEAHRILAAEHLAPALHACVPVCGDLFMVVMDRVHGEMAWEAANRQELLPYRIYQDIKRAIALLHSHDLVFGDLRTPNIMVVPGGSGPDDGHRGMLVDFDWVGTHDRGRYPASLDDGLPDWVTSSIQRHGIMDKAHDVAMLDQFKEQCHSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHQ4</accession>
    <name>A0A4Q9PHQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_228708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145248">
        <property type="protein sequence ID" value="TBU52506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHQ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="375"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="843" mass="94168" checksum="BB32DAD42B9D0CA0" modified="2019-07-31" version="1">MTAVIPSSRSPMSSPPEEVEANHEGCGQSESIGSYDPLEADTEDVDEDFLANHLRSPPTFHATEEMLEKVEKIQNVGNTEKSMYQPLASLLTTMSEALYKTLTADMQEKLRSRHRVPAGEPGHMSFINHSSSAPRHFPADILCDVKDAPDLLGVYNVGDFSSDVDGVYKGVPHHRVEAIVEAKPIAKSGGRDQATTYAYRHHQARPDHPAFYCLVVKPDWYQVLLSDPTGVVASAETVWGDLDLLAAYIYSHYDPPRDHFLWDETIAWIPGESLADPPTWKVNVQGQWYTQGRFVFVGEPWGRRTTILRVSDDDGGEIVIKEVYRHHQRRCKEEEILAHVHGDGDVLGVVRLKGAEHVTTNNETIRCAARGEETVRTKERFALFDSGSCLLDAKTVNDLLEAVYDALEVHRTVLLERKVLHRDMSLYNFLMYPKWGGVSGRPVSEKTPVSIRDVLRGSKRPAEERFPACLLIDYDNAAQVQVTGGELKERTGTPLYIARSVSLGMVLLDFESLFGTFMPRLTGDALQLYTTAYGQERYDRYNDDPVTRTCHGGYPPTQNSHPRAVREAKSPAFVHRPEHDVESVYWTLVYALLRVQPAAAPRELDPSAASASVWNTLLSHYIPGEEYDRSDEKRHEVMNRTKQEWLDLFHATMEDVALLLWQITLHVCSEYALWKWEGNFHPDHLHEAVQRLILQYLVDHRDNPIELDPDHLRPTDPRSTHQGDTLTPTQLSRTQANSVSGHTAGLGGSGRGSTATRKRGRGKDSRHTADCKDGAMNTTAVGGTSQQTVESRKQATVNQPAPIAANLKRKLSDTKPSRSSKRLKTLSGAPVPPAGQGGDHDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHR3</accession>
    <name>A0A4Q9PHR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_970373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145218">
        <property type="protein sequence ID" value="TBU53302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHR3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHR3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="311" mass="33490" checksum="948D22AFE295BB7C" modified="2019-07-31" version="1">MAPSSIFPLSASMASSLSYQAVEAVVSSNYCIEPFSLAWTRLCATYIWSLSRLRRRNEWSVDGVDIALQEVSSRPTSLISAGDPDDVVDVVDEPCVFFIISPIMEGLCGGWATLQVAMSAYGWGCTLGVFYFGFAMASAVGAFLIRRPFIPIFSPAVGVRKGALTTTPMFYVAVLASFTNLMLALFLFLESLGTKAKGTLSPLLALTMPGAEELVASSVCSTFHIVPGETVTSPNGWKDEDWSMMLWAMVLFGPLWPSSVGATTLSYFGMSLNPAAIGPWGLALHVIDSRTVGPKSRQLCIPFLSPQHPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHS3</accession>
    <name>A0A4Q9PHS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_952655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145246">
        <property type="protein sequence ID" value="TBU52546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHS3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHS3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="512"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="670" mass="71076" checksum="AFB38659E5994AF5" modified="2019-07-31" version="1">MSATMTQTRASPSLITSQVPLVAGDVLRAIDTPAVSPPPNSSPPAASPTAPSAKKGHRRTSSAASDIAKAAGIDLDAVSMAEARKVMSEEHKILGFRPPHGSFAAEVQSVAAKHPDRKPGAGPAVDTSKLKEIAREDALRILAERKSSPGTDTAVLPTSSNGAKTPAHGADAKHAAPARHSPPEPGLDLDKISATDARVLMSHEHRALGFRPPPGSLAAEAQAAAARHPDGDGTHLDDGALRAIAVRDAERIKADRELALVGDPAVNISAVDKDAAREIVRAEAGALGHRPPRGSLAAEAQSAGDRHPAGASFNPGRDRGELEGLKERAREEGARLREEVMGSDGQGVVNGASYVDPTLAKDLQQNGAIDEDKADAPAKVDSAVETEPMTEERPRVARTLAAAPLKRQETTDSVEIVGDVLAGHLRVAAVTNHALLRLCGGAAELPPPIPPRSIFKFTFSLPVGSGQASTAGVVTAYLSDISSAREHNMSAASLAADINLVADGANVNRVAQAISFTILYYDFLLTFPQEVERYWTGVRSWASFFFFLNRYMSVVCYVPFAYEFYADMPEPLYHRLLLASTQCVAAVLLMLRTYALYNRNRKVMALLSSMAAIGGAVIVVWLLTTALWGRSSLLSDTSRQWSIASAPWDEHKSPDVSPLVGCDLRISIRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHV1</accession>
    <name>A0A4Q9PHV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_887928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145216">
        <property type="protein sequence ID" value="TBU53371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHV1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="564" mass="63994" checksum="1006B237DECFCCC3" modified="2019-07-31" version="1">MRRIDKGYGVSEKSSHLAGLRDIARFLPRQYTPYDNLNSMFVTGMTIWQLGPMSEADRTKRIKAVRKLKFKDAQYLVFVFEDLIKEQMIFRNYAEKLKNRPQDIMAVARFPTFHIHYHARAAHTSDIRTLKVELPKFFEDVQVAPDWGVSALSPVEFEKRERNCGLYSDCTARLLVNINERERFDRNGTIYRMKKLAETPELKKKCLRKHPETDENSSYPSFLFPATLQYDVNNPSYGLFKGAFFRKCVRTLLTGATSANQPFGVPGTGRSTLSKKHNIYCVTSAMIAYVASLVRFLLSEKKEWDGDDADGSGQLLHSALRDFLDLEFEAHENAAEDGLFQPGSEIEEINENVFAYYNRWIFGRAYGDDSVRLRQLQQKNRSLYDDDDAGNDDSATWVTRTIREQALITRKARLQQMAMRRLEQQDDTSTPQSSQGVSYADDEEPEATPAHTEDVAGQNSGAQDYAGGTQAQGPVAQHTDLETYCSARPSLSDSLKRFYGFGLLPLVPGTSKFSLVSTVEQVMWAVVFHALIMCTDCVPQCMLLDVTVWRGNCMATPIIMCESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI67</accession>
    <name>A0A4Q9PI67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_190951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145232">
        <property type="protein sequence ID" value="TBU52916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI67"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12472" checksum="FB001517CEB6BD65" modified="2019-07-31" version="1">MLLFNGLHIMLNLIAEVSFLGDVADTISSILISRFIINLREVDSQDRPSNETTFFNQSSHDVTSFTSEREGRGGLVFAENFVESMGAPLDESCASSEMSPEVEEGYTRCDVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJC1</accession>
    <name>A0A4Q9PJC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_1041961</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJC1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJC1"/>
    <dbReference type="OMA" id="WLKQANP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU54187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="871" mass="98849" checksum="86652EC355B272C0" modified="2019-07-31" version="1">MTSTIDPSTIGKPTKQAKASPRRHVRSLTGFTPEKDASGKEKWPIGDEKVWKEGIPGLTQDTPEITKSVVHHVHTSLARQAYNLDNLGAYQAAALSVRDNLLVNWNDTQLQYSRKTPKRAYYLSLEFLMGRTLDNALLNLGLKDKYQDGITKLGFNLEDLIDQERDAGLGNGGLGRLAACYLDSSASQELPVWGYGLRYKYGIFQQHIGPDGSQLEAPDPWLEHDNPWELARTDVTYQIRFYGHSERFEGNKGIWSGGQEVLAIAYDVPIPGYETKTTNNLRLWESRPKRGFDLQSFNAGDYERAVEASNSAEAITSVLYPNDHTTFGKELRLKQQYFWTAASLADIIRRFKNTDKPLTEFPEYVSIQLNDTHPTLAIPELMRILVDEEDVPWDQAWQITTNTFFYTNHTVLPEALEKWPIPLLENLLPRHLQIIYDINLEFLQAVDKKFPGDKEKLARMSLIEEGFPKNLRMANLACIGSRKVNGVAELHSELVRETIMKDFVDFYGVSKFSNVTNGITPRRWLDQCNPGLSNLISETLKIPKAVFLKDLYKLEGLLEFVDNPAFQKKWAAVKQSNKERLAKHVEATLGLKINTRAMFDVQIKRLHEYKRQTLNIMGVIHRYLTLKDLSPAERKKVNPKVVFFAGKAAPGYYIAKLTIRLIVNVARVINNDPDTKDILSLYFLPDYSVSLAEVLIPASDISQHISTAGTEASGTSNMKFCLNGGLLVGTVDGANIEIAEEVGESNVFFFGHLTPAVEDLRYQHMYHPVPIEQKCPPLARVLNEVSSGRFGDGGVYEPLLNTIRQHDYYLLTEDFDSYIRALELVDEAYQDRTEWIKKSIRTTAKMGKFSSDRAIQDYAQEYWNIESTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK45</accession>
    <name>A0A4Q9PK45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lanthionine synthetase C family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_70987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK45"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031179">
        <property type="term" value="P:peptide modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04794">
        <property type="entry name" value="euk_LANCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007822">
        <property type="entry name" value="LANC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736">
        <property type="entry name" value="LANC-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12736:SF7">
        <property type="entry name" value="LANC-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05147">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01950">
        <property type="entry name" value="LANCSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM01260">
        <property type="entry name" value="LANC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158745">
        <property type="entry name" value="LanC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="535"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR607822-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="61871" checksum="D65B1FA5677C2542" modified="2019-07-31" version="1">MSSATLPRRYIPHSNTPPTDIKPVKHRIHEALAENVLRVHRHPSTSPKVYHGSAGEIIMDMRTFGILPSKNFPNTATSSLIADPFHEPRDGSHVAYLETSVGPATLVLVRQLRLRQSPESTANKHARRGKLDGELLDEVELSETWRGAVDLLRSAQEVAVSEALDDDGCEVLYGRAGLLYALLVLKSELAVTLSYLEQTRKTKDKIVRDVEKLCSHENLKELVDDIIKRGEFGAQRYAEELEESEKANAPPLIWKWHEARYLGAAHGVVGILHPILYAPSDLIKPHWDKILATVQWLLAVQDPLGNWPTKAGRHMPVIPGGSATHAESKHVAIDEEHDDSLVQWCHGASGFLMFFSALLRRASLSPSACPLPPSLRESIVAAVNRAGELVYTRGLLRKGVGLCHGVGGSVYALLAVSDALDSFSSPNAPSSRHANGASPHSHGFSGLARSMTRSPPLPADLDEQHAHWFRSALHLADLATGWRVLMQEGKMEIPEHAYSLYGGVAGMVCAWAEVYTRLTGHAKEGIAHGNGHVPGDAGAGAGAGEAHSHVHAPQRRGGMPGFDDLAMFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL15</accession>
    <name>A0A4Q9PL15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_727132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL15"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22215" checksum="6E53707CA892B715" modified="2019-07-31" version="1">MALWQRDAAATHTISVSSFHHRSQDLGSDARQASVHQFLLCSVVICVGRRATAATRSSNLWTRTCPLSPADHMRKLGTSSTVGATYPFHISLLEPFSASLAQTCTTRLSRLTDCCSSLHSNTSNGSVHSQSSHYRPCDRDPAWTVQFKRIQCGVSGRVRLLFCMYLRPDIGVALSKNMAWFSWICPAGRLASPFSLLAVGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLP8</accession>
    <name>A0A4Q9PLP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_713156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLP8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="111" mass="11958" checksum="DC0BB7324DAA9EE8" modified="2019-07-31" version="1">MRRTVCLQEEKVSHLRTQRDLTHDTVLGLDHFAGSSCSESVRNGGGSVYQNVCTPLLYPPKDTVGTGGSLGLDWAYCASQLYSRFESLWDDVGSVLAVAVLSHAEGICGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLT5</accession>
    <name>A0A4Q9PLT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_934366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLT5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLT5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48038:SF1">
        <property type="entry name" value="RIBONUCLEOPROTEIN RB97D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="165" mass="20216" checksum="0C0948A718840835" modified="2019-07-31" version="1">MPLFSQRSYAFVEFRSQRDAEDAYYDMHGRYFEGSRLSIQWAKNPPSSVWRFDRRSPPPRRDRERSRSPRRRGGDRERDRGYDRDRERDRGSDRDRERVPDDRDKDRDDRRRRSRSPDRRRSPSPDRRGKEDRARTPPPPEEVDRKKDIKDDEPRDRAQTPPRDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNM8</accession>
    <name>A0A4Q9PNM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_855978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="188" mass="19934" checksum="23A63B159976BA7B" modified="2019-07-31" version="1" fragment="single">MRKKAAIETCPGDDDAANSPSTCTTTMSTSRPSSSKMPATSTPPPGPKIEYLISNVDKPIVSIDGQQYSTKSLADFVPELLASATFADDLIQGATSIYIAKPPPNHLPLLDFIANMLQLGYNTYLNHPTTTPPPPVSSPAPAPAPSPPRVSPPADTRPPTCPQTPPPSAPLQQTRTTPKNKRPIRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP14</accession>
    <name>A0A4Q9PP14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_641585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP14"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="17791" checksum="21DEFADCCDDEB3A6" modified="2019-07-31" version="1">MDGSHEGGESNHRSPSTSEGAGTIQQFRLSSTNAIFPQDPLVGMPCFLMEALAREAAPSGSTVRQHRQAAPSGSTVRQHRQAAPSGSTIRQHHQAAPSGSTIRQHHQAAPIRQHHQAAPSGSTIRQHHQAAPSGSTIRQHRRQRAIRVLCATEQTVLLSLKSVSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPB5</accession>
    <name>A0A4Q9PPB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_932034</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPB5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12574" checksum="93B270BEA21BB19C" modified="2019-07-31" version="1">MEYTTIATYYNVVGNRIDSLTDGHLHSPMDGMRRPTTGETHKDLRTIAYRATPKPCTYLHTSAHICGDHAQNRRAYLVFRVLMDTVTSCLGRRVRYGQGKDASWAQSQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPJ5</accession>
    <name>A0A4Q9PPJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPJ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7872" checksum="7B70A356EB7DCD94" modified="2019-07-31" version="1" fragment="single">TPPLPALHSVGDVSADKGRTGKVSRAPKHTLLQISERGNNIEAHESHKDMPMSEPLPALDALARASRQTAYCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPS2</accession>
    <name>A0A4Q9PPS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_931780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8195" checksum="D968055A5AC51FD1" modified="2019-07-31" version="1">MLRVFLCCGGASASPPTPFVLARSLASCLIARELESTQDDLSQQAAVPVPIHTSVRFDPRSSPYLTLLRMYTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR46</accession>
    <name>A0A4Q9PR46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 9">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1 9">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_854240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1 9"/>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR46"/>
    <dbReference type="STRING" id="114155.A0A4Q9PR46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000001">
        <property type="entry name" value="Tyrosine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02006">
        <property type="entry name" value="Tyr_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024107">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF0">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="TYROSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="436" mass="47985" checksum="655DAB64A2DCBB23" modified="2019-07-31" version="1">MRTRGLVADITRPDQLEIELQKQPQTVYLGVDPTARSLHVGHLVPLLSLLHFQLRGHQIIPLIGGATGLIGDPSGRSTERPLTARETIEYNVAQLTAGIKQFFERAQKYAEKRIPSSLRVLPPNVQNNFNWLKDLSLLEFLRTVGFHSRVNTMLTRESVQARLSSQQGISFTEFTYQLLQAYDFLTLHKTFGCTIQVGGSDQWGNIIAGIDLINRANSQDSGALVEKGFGITTPLLTTASGQKFGKSAGNAISLNEDDTSVFELYQFFLRSSDADVGRYLKMFTLLSLERVDTVMETHNQNPEARSAQRLLAEEVTELVHGEDGVARARLATKILYERDISTAKTDNVLAALRGNPVLHVCDASEVLDVPLTKLATTLSVASSNNAARQLVASKGLYLNNTPVADVQQKLTPADFIDERLAFLRAGSQKVAVVALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRB7</accession>
    <name>A0A4Q9PRB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_822742</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRB7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU56937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="356" mass="39137" checksum="93986368EF04793C" modified="2019-07-31" version="1">MSTNMQFKGYALIDPSKWTDLQVREFKPKNFQPDDVEIAITHCGVCGSDVHTLTQGWGESKLPLVVGHEIVGTVTRVGENVKDFKPGDRAGVGAQRGSCMSCRACKDGYENYCPNGIETYNSEYPDGVVAQGGYSTGIRAHQQFVFPIPDEIESRDVASMLCAGLTVYSPLKTHGCGPGKKVGIMGIGGLGHYAILWAKAMGAEVHALTHDQGKIDDIKKMGADHVINTEKKDFWKDYPQTLDILLSTRDVHGEKMPLGDWLSMLYVHGRFITVGLPDTDDPLPGIHAMKFAANGCMIGGSKIGSKQDCLEMLELARSKKIKPWIEEMPMKKAGTALQNVKDNKVRYRYVLTQDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRH0</accession>
    <name>A0A4Q9PRH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRH0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7562" checksum="B6B27F7A59C93CF7" modified="2019-07-31" version="1">MPAHRLSFCIPGVASLEGSGPRLPYQRAGTRVGMVGRRRTGTADRSSPCAFLPFIPRCLDVVDKAAAKAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSL4</accession>
    <name>A0A4Q9PSL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_556649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSL4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="426" mass="46364" checksum="5C42ED30016DC42E" modified="2019-07-31" version="1">MTDFASLFSWSRPRVEKSLPPTPSNTASRRSSPIPIPRRRSVHPPPCSPTRSQDSPELVFNFDFSLSPDAPDATAHVLFQQRGANMRRLPLQKAAYSPLATLGTNHQRLAHPYAQEPFLYPVPKPPPATEKALSKVGYADKSLHALKEQIAPDPPARSTYSSPSASSLSSSRSSRPSCLPSANASSLHLDTDEAFPLTSAFERPLMSDSVASSYNSMSSFQDIESLSLSPPTPYRTPSPSPPRLLPSDARLRQATPQRPAALQRTQTAAPVVSLNVTQAQRSDRSSGIGRGERSRSPSSGIVPPRTRRSSSVGAGLDLTKLRDPTRRMGTVVGRGAGRVISMFEYGNVNARSLVSDEDIEGSLEKDHADRPRDPERDRRLAVEREKDGVQGCGSPVLERGRARGRAGVAAPKRTRALPGWQWMDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT75</accession>
    <name>A0A4Q9PT75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_778145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT75"/>
    <dbReference type="STRING" id="114155.A0A4Q9PT75"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="264" mass="29076" checksum="D9AAA58F5523A330" modified="2019-07-31" version="1" fragment="single">MGFFKRFLSLGSSKSRKNKKKQRAAHAIVDAEGRMLTQRPAQDADSNANRLLRSSSTKFSVMSAIDYTQLPPMPPLPHSMNDLLATPPLTPSPSLVTVATTPGLSRSGTYLVKVHGRTTHSRTEFPRANPPASPTKAHKKQVSSTSEPAEHDTSDDEDYVDPEQQPRLKAVNFTPKDTSRLYKLRRDPSVASLLDLYDDHGCLDSNAFANSPPSPAPIHDVSEGREPRPRTGSTLRQLLGEPAFAVNNTTEGDISWAERFLEYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV90</accession>
    <name>A0A4Q9PV90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_819576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV90"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV90"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="341" mass="37930" checksum="AC9713E31F97CD70" modified="2019-07-31" version="1">MDSTTPLSNLPPELIISIFEIASCDHQQAALSISRVSTWARKIALPHLFSTVIYRSRPAFAHGMSSGARDPRTARPSHSQCWGPLVRNLWLESSGISNASNEEALIRACENVENLALMSQSLPVLAASIQAENAARRGANSKGSLSSSDPSHCRLRSITLITHTFRFVWDSLVGLQVQDGSQLLHNITHLHILDLTISSFTPHNLLPNLTHLALPYLDLGIDFKQDALRLSPGALGHRALQMIVLTVAEEKWLNNPWYHIARYPGQTPSPKPMFRLLVRWAREKDERIHVVLSPQIGDDPCKEWVKAARGGQSLWEVAAKTRADDSHGLGLPDAFPKNRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW05</accession>
    <name>A0A4Q9PW05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_977270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW05"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU58564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="414" mass="44069" checksum="EB0DD4CB0A14A2B3" modified="2019-07-31" version="1">MENNTSSPSHDKDTSETIVMDTSKDSESSAYQMDGGRAAWLSVLGGWMAAFCTFGAGSSFGVYQDFYTLKGTSSPSNISWIGSMQFFLTFAMGLPAGKLLDAGYFHHAQIVGAILYIFSLFMLSLVDTSKYYQIFLSQGLGVGLGSGLIFVPALSVQAHHWKRRRALAIGIVLSGTSCGGIVYPIMLNQLFNDGHAGFAWGVRASAFLSLGLLAIANATMTTRTSKINAARQVSTTGSSQIFRDIPYWIAAAGATLTVLGLYIPYFYLQLFISVHGLSSTLAFYSVAILNAASFFGRNILNFLADSVGQFNVTCPVSIISTALVFTLYGATTPGGAIAFAILYGFFSGGFASLLPATLAVFSRDLSEVGIRIGIGFFLTGFGILCGSPIAGALINPGFHWSKLIIFSGGVLYYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXV3</accession>
    <name>A0A4Q9PXV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_383481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXV3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020792559" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="17673" checksum="B1EB7BED93252FD5" modified="2019-07-31" version="1">MLANAKLVVLSFALAFAGVTALPQGATSTDVVLPTETILSDTSIVVPTGTDTATVPASASTSVPTDTATSAPTESTDTLLTNTDTVTTSVSGVDPSGTSTALSLSDTSLPVSGSVSSAGGVSTTVAFTTTTPASNSVSGSRSGTGTSAAASSTSTGTNNNGAVAKGLSGLTSAGVAVLGVLAGAGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYP4</accession>
    <name>A0A4Q9PYP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APC amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_816235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="8 9">CBS 464.89</strain>
        </source>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ21</accession>
    <name>A0A4Q9PZ21_9APHY</name>
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        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="175"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="56673" checksum="0BA593595695F35B" modified="2019-07-31" version="1">MVQDPTLAACLGSGSNATFQFLGQQVAVYGTEYGQGATSSYSIDGQIISSHTSQGSGVGVLLFHSDVLSDAIHTLVINVTAASEAVPFTFDWIEYNSTARGASQTATIASSISASLSSQTPSLPPSTSMEDPPSASHSLATGRASKPSVSTVAIVGGLVGGLAGLTSIILALVALRNRRRRRMSGPTQYSYGEVAQYDTDNFVVPELGAEPPAIVVIPADATVSMQAVYICIPPGPIDIPSTAFATYILDGIPAGPSYYVPLTDRNLFIPRFAHFTSEEMLAIPGGTHNLTIEASATLEHPYLLDYIVLWNKYLGPNQTYPDSPTLVSTLSAPPASGTVASTGQTGVTPVVGVSNTSIPSPSSVLSSPVGSAPVDTLPSASFQPSSRSPATSYIAGAIAGSIAAAAALVAASFFVYRRRRRGKGTNVPTDDSSNECTYPDHQPLMDEAQSSRVGAMGAAEGHLHDAPTNTPLGFYTSLVRHETDRGKVKEIHLKPSRSDLSDYFGSHPDMSMEPHIITDDAPAETLPLYTRSSGGESSQMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZQ0</accession>
    <name>A0A4Q9PZQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="12 13">
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Tandem AAA-ATPase domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
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        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="11">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="10">
        <location>
            <begin position="352"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="530"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="815"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="404"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU60066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1083" mass="122624" checksum="335E1B64733B502D" modified="2019-07-31" version="1">MLHLIQMEHHPESAAATEINLHAGVNGRGSMGPIANGVPATNGNALTSGPVTNQPYLQAPQTPVSFTPDQINALRAQIHAFKLISRGMPVPEQIQQAIRVPNQAIPDLQTLLHGADVNARVIDSAVKIHKSTNGTPVNGVVEHPPVAEVTPAPPETIKEEEIEAVDPEKLPKGPLLEEDVNSGIYPYNAYTHPLTFLKCDPDVSSALWATKMQRLLVPSVMPVGLDPHQAIEERNAYIDARIEQRMRELEAMPAMMGDDGLENPLDDAENAEPQSLEQLAHVHPPPNTHGKLRALIELKALRVVDKQRQLRASVAERLMHGTLLPLNRADFRRTRKVQLRDIHNTEVAERKQRMDRERRAKQEHIEQLGIICMHGREVLAVGQAVQERVTRLGKAVLSFHAHTEKEEQKRIERLAKERLKALKNDEEEAYMKLIDTAKDTRITHLLKQTDAYLDSLAQAVVEQQRSEGHEAVDYDMEEGPVSEATFGAKAFSQEEDKGKLDYYAVAHRLKEKISAQPSILVGGTLKDYQLKGLQWMLNGILADEMGLGKTIQTISLITFLIESKKQRGPYLVIVPPSTMTNWSSEFAKWAPSRKVLQTDLRTGNFQVVLTTYEYIIKDRIHLSRMKWIYMIIDEGHRIKNTQSKLAQTLTQTTSLPELWALLNFALPKVFNSVKSFDEWFNTPFANSGTGDKIELNEEEALLIIRRLHKVLRLFLLRRLKKDVESELPDKVEKVIKVRMSALQSQLYKQMKKYKMIADGKDAKGKPGGVKGLSNELMQLRKICQHPFLFESVEDRVNPSSMIDDKLIRSSGKIELLSRILPKFFATGHRVLIFFQMTKVMDIMEDFLKMMGWKYLRLDGGTKTEDRAGHVQLFNAPNSEYKVFILSTRAGGLALNLQTADTVIIDWNPHADLQAQDRAHRIGQTKVVRILRFITEKSVEESMFARARYKLDIDDKVIQAGHFNNKSTQEEFLRSILEADQEEENKEASDMNNDEINKIIARSDEEAVIFHEIDVQREREALEKWQCAGNRGKPPPPLMQLEELPECYRADEPFAESDAIDESEVVDAIVVMLHVCTNQTRPGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZR4</accession>
    <name>A0A4Q9PZR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1038071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PZR4"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="266" mass="29177" checksum="D5D0B168E07B4570" modified="2019-07-31" version="1">MLRLLASRRALSVVAVAVGVHEAHEKLPIYPTPEAEVILVETPSELEKQIAVARRAVTGTYLDARSRVQEVVSRWIGVEQAVESRVKSLVAPDEPLTPGVLYVGVATLTGSVLARNRLFWRLTLPPTLFLLSLNHFLPKTSHNVSQYLGSLEEAHFPALAEKHEIAKAHSAMTWERVKDATRNSRETVSDSVAALLGKIEGASGLKLRETLGVKGREQVRAVEGKAIEAVHAVEKEVEAAKVVVEEKGQEVKEATQKKVDEVKRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZT2</accession>
    <name>A0A4Q9PZT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_779045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PZT2"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="20670" checksum="DE0F2617C1EC3828" modified="2019-07-31" version="1" fragment="single">QWDDARQALYESHIARLTAAGSWSLSWTESPQWLSFCDNFLPMGVINPTRKVLTSRIIPAEVEVYRTQARTECRQKLGTVQCDGFNPKNRHHIVAFMLTVPDKKETRVYTIRTYDTSNEPKTAENLLKMLREVLQLLREEWRVIVIAVTSDCSGESRKARVEIVKELPHLIAPDCYAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZV0</accession>
    <name>A0A4Q9PZV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_815370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZV0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9715" checksum="0385A7A2F1677307" modified="2019-07-31" version="1">MLSRTRELLDRAKERVAMLEVNISSAKARNRSSPQRARQTELERMSWQRSENYITLSKTAGGLRFRKVSLILMFISKPCISLMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZV2</accession>
    <name>A0A4Q9PZV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_875660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZV2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="575" mass="64125" checksum="B38CA8D377654EF4" modified="2019-07-31" version="1">MYPKHLRSGSPKPQASTASSAAPESSQIDQSTVIDTSFGVKLRFGLDITSPAASRMLDGRSHRYPVTHPKVEHSTNEHSLTLLSSFSQDLAPSPELTALAVAPLAPPAFHDISQTQCRSCPIVIAPNNFGREPDLQATPMRRPRTRSPSVWALAPRSWRLLRAKGDRPMVTLTVPSPPGAPLPLPHIHEQHLNPEPMSPENDTQQSPPPDQHRRQYSNVDGDDLESDDEDDSWIPRQRVEQYSVSHDIAQTICSAAIEGEFIQDEIILRPHIETPLHWKEQRDEPLAGPSVRRRRSPDTLELRTTSSYDRVNELIRALNTSEDLTDIALEPRPLRYRRVLHEFINPGFEAFQYRGGVGFLNPLDTAVDMIAEGRDHVKGPSDADHDIVDISDSESSQFESDEEVEPEREKSMVSPTDDQVRMGERSRDRTNTGNSWRSLATSEEYPQLPHLPLPQTVASRDLPPSPASVSAAQIHEAGRVGSAFAEFSLLLLPKHKMVDNGRIAYYTMTTVLPCRRSMPPHLHQGQHAKFLPTNAELGMPLHSTMPYGSDLSYQRTYTSFIIVTPSNALAIQSMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0D1</accession>
    <name>A0A4Q9Q0D1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_330467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0D1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="23550" checksum="81899FFE5CCB1C62" modified="2019-07-31" version="1">MYQSRPRRLPYTSRHTRDAHAEMICDRHSFAPSISVRRPFRGHDRCRNVAAKAGRHVWRSRAHSLVNMSSMTLRKVIYDANAMHEPRYQCRDPKKPQSTTIAIGLYGGVLYAAKTRDQSSNASAPVIKLKCAAGGQMYDKEGEDLRLLRQIARDSSPCPRASRRWSFPHAISPKISQFKLSMQFKTKRGRGRVVGHIRALGHRRQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q144</accession>
    <name>A0A4Q9Q144_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_814980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q144"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q144"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="276" mass="31361" checksum="C9C051AD17600D96" modified="2019-07-31" version="1">MSRGGRGGGFGGRGGGRGGGRGGFQQRDNGPPDTVFEMGTFMHAVEDEMLCQSLMPDKVPYFNAPIYLQNKSVIGRVDEILGPINEVYFSVKMGEGMVASSFKKGDKVYIGGDKLLPIERFLPKPKIAGANLHSFLIVHSAEHPRFRCQKAPGGRRTRGRWRARPRWTWWARCPKGRPWLWWWVRWWTRRTKRQGHIRWWEGRTKGARGRRTRLRSGSWLITSVYSDAIVVRVCSAILSLAIVSFLSYVREGVVCRYPYESSGMMLRLQWGGGILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q216</accession>
    <name>A0A4Q9Q216_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_998396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q216"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="430"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="456"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="118"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="563" mass="62956" checksum="6F86B36AE356246A" modified="2019-07-31" version="1">MLVTGYPAFAQKELMDSFAARDSIDVTPRASEDVTVRGSLDFPIRESVDSTVRGSVNIAARKSLDQTIRASTDTRLEFKRTSMDSDKMSEIIEKEIDSGQTTPVEEFLNWSGWYKWYLNMLGGLLGFVTTFASSAPSGYATDLLAKFHLDAELDALVISLFVMGFCVGPLLWAPLSEQYGRRPILIISFLGFTAFQIACPFATHFGAIAAFRFLGGVFSASTQPIAPYFLHDSWDDATREKALIVQAILSFIGPTIGPLVSGYMAAANIDWKWCFWMLAIMTGTCTLLIILTYPETYRPILLTRKAKRLRKETGDVRYQAPLELVQSPKLSGRLHDTLAKPFIMFLLEPMLIATTMYLAFLGGCLYMLLEAYPVVFQEGYHFSSSTLALTYLPVTAGNFFALALHLWVIQPEYEREVKAYAPNPVPPEERLWVAVWAAPLFAITFLWFGWTSFPTINFWVPMMSGFVMGCTMLLLMVAMFNYIVDVYAFAAASALSSSMAIRNVFGAVFPLFSTQMYRALDPRWASTLVGCVAIVAIPIPIVLKRYGPAFRAKSRYHDPVRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q295</accession>
    <name>A0A4Q9Q295_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_873693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q295"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q295"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="120"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="583" mass="64905" checksum="BD299D78409E8D89" modified="2019-07-31" version="1">MLQETLQITVGFRPTSGSHAVTPKGVHTLRLVVDDMPHFMYYVYAKQEDPAASLLVARPRVLQLNSPSTRAMASSCITDCIRKHTRCPPPHNATLPSRVIDCSDPTKPKLRLSGGDTASYVILSYVCGEDQPYRTTTANLDSYLLGIDLAALPQTIKDAIETTHNFGVRYLWLNALCILQDSEEDIAREIAQMHTVFRGAYFTIIAASASTASQGFLQDRPPPSPPDVTLPFRCPDGEVGTMFLSPVWRQYDGSAEPVHQDAWCLQERLLSPRALVYASHTLQFHCQTSIVNVGNFVCGPTFGARLPDLLLRPDAELPSGSPSVLSQSERKTLQWSWIETVGDYTHRTVAKPDDKLVAFASIAELFHRAWKSDYLAGLWRDTLTQDLLWYKTFETRYPRPDTFRAPSWSWAAIDGRVMAYSVDDRLDPDSKDTEACEVVSCEVAVATPLLPFGKVRSGTLTLRSVMLEATWNPDSSMPDLYLKTSDAASDSTVNPVSSDPPEITTEPRHIGCAYPDSTEDVQEVWAIPIQWNQSARYASGLIVAPHPDGGNAFRRVGFFHSPEDTHEGLMWMLNQEKRDILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2N3</accession>
    <name>A0A4Q9Q2N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_197872</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2N3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2N3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="34442" checksum="C5971A611ECD35C6" modified="2019-07-31" version="1">MSTTTETTVIAAKVALPWVSLEESEKFYNLNEQEIAFFKSATGIHDEAALKEHMIAIQREAYAIHAFPCIRMFSFTKLKLARLPGYEKLLELGKSRKNPIFLDIGCCFGNDVRKLVADGYPMESCMATDLHPEFLKLGHKLFNTTPETYRVPFLAGDSLNPEFLAVTHPFYTKPYTTVPKLSSLTSLNPLHGHVSAISVCSVFHVFDEAGQLQLARAIAGLLSPETGSMLIGVHSGRPEKGTFITRAGGRDVSTFYHSPESWTALWDGELFVKGTVKVETKLIETGGWDFQENTDRYWFLYWCVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q383</accession>
    <name>A0A4Q9Q383_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q383"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q383"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="683" mass="77865" checksum="D8C47C92422037E0" modified="2019-07-31" version="1">MSADVASIDLQVVKSLTPQPTFDMSIRARADSSDATASGLISLPGIRRHLRGRRGGLKDMPAMPLDILFEIFGFMHPRDLLNLARTTRNFRTLLMSKRSTSFWKEARKQIEGLPKPPYYLSEPAYANLLFFPHCHNCLKSNIHTVIWVFSARYCRSCQKDLLTTNHKDMDDVLWKIADGNPSEWNDLRYRSQIFRRYNGKIFKPEVEMIHTQWAARDGDEKDAYLNERKAFVVVCREYAQLLSEWKEEYQTIKSAELDSLRLERLSSVKVRLREEGWGHALDDINTYTLDRRLLTVKALNRASKLTDQAWKIMRTSLIGIMTTINEERLDRKYNARLKYLKEAIQTYRASHFPRRTAESDREPGFAEFAHLPDFRDLIMQEEPDDIVQASLLSLIDDIPNYTAAWVYRNEEVFVQKALTQLGGDFEDLSTDPPAFLELAIVSFTCTQCRRPRLRWPGILTHPCLRRSYVPNDTVDSAINKYELAILCHTNNVYDAPFQGEELTVFDHHVNVTRAVILACGLDPTTATYDEVEGCGARFAPSNTLAAASRKPIYDWQGVVRYLSNNQGISAGREEFELSDHFERVSDAEAATAIKHGSCAESNTAKTQHAVSCNDRRVFGCTACPTWGYHPAMWSHVQDNKHGCRRAPAAVIRSFLYLHEDSKPQGAPVVFLDFASRGAGGFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5E4</accession>
    <name>A0A4Q9Q5E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_919958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5E4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13308" checksum="8C48444063094100" modified="2019-07-31" version="1">MPMPSFCLNLDEPCRQHSVDTRNGPCQSSPKRGEVVCAEEHMLHYCGRRSASPGGCSARRRSLSSCVDRASSTCVHAGSCRDERFPSCLCFVLLCHCAVGKEDVRCLVEGYWQRRLGVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6U4</accession>
    <name>A0A4Q9Q6U4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1036194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6U4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="19866" checksum="0F8FF7BDB44511C5" modified="2019-07-31" version="1">MPCATVSAASLSTACFPTSSGRTAPPPTSVKTSDDRILPPPSEEAVDMVFREVLKLFNPMPGATLGDMREEPSPEGLQRSHNATLTATLHTLPLLVLSHLLHKHERGKYQLECATYSPVLDAALRTWATRREGWLSTVADWAPQQNGATGAVSQADDFAVLVGALFGGQPREFQRAHQYSASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7K2</accession>
    <name>A0A4Q9Q7K2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_917548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7K2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12715" checksum="C226F436EAFB12C2" modified="2019-07-31" version="1">MRRWRSAGGRDRHHRPLSANAKRQSVSVDCTVPASRRTDAWRASYVSHPAANVRRPMCTLYPWHQARRSAGGSIDDRRVIMLLCVYVPGHIFCVHTWIPGLSHSEHRAFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7N2</accession>
    <name>A0A4Q9Q7N2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_964816</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 20">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7N2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13857">
        <property type="entry name" value="CuRO_1_Diphenol_Ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13886">
        <property type="entry name" value="CuRO_2_MCO_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="109"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="235"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="483"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU63512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="550" mass="58754" checksum="2C75D31215A15109" modified="2019-07-31" version="1">MSKTDSGDNLASEKSGPAKAASTGTRRPLIIGAAVATTVVVLALALGLGLGLGLKHHHSSSNSSSADGTGSLAVVTSPDSSAAFLSATLLNDPPTTRTYDFVVEERTGFPDGVEKRMLVVNGQFPGPTIEVNTGDRVVVNVTNKMSNATPTFDAIMRTIHWHGLFQRGTNFYDGTDAITQCGIPPGQSMVYNFTLDGYVGSTWWHAHYMTQYTDGIVGAFVVHAKNESVPSYDGDLVIQMSDLYHGWSPDLLAFYFTPGGIDGTPGNEPVPDGGTINGIGQYGASASTPNASFWNATLEPNKTYRLRLVNTGSFVAMQFAVDNHTLTVIEADGTAVTPFEVSSVSVAIAQRYSVLLRTNQTAGAYWVRADLDQTAFTYNNPGAQTEVRGVIRYGVANDTMPDFSLLDNPPALPDGSPSELDTSDLAPVGGGPAPDATFQVYFTISMQYANTGSDYLSKFLAFINSTSWQPLQGTASLFSHLGNVTTDGSATFADSQLITTVNEQHVFQMVIDNLDDGDHPFHLHGQKFWIVGQGDGRFQGQTINNTLPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8F0</accession>
    <name>A0A4Q9Q8F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_945317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8F0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7792" checksum="A2ED0058A93DED32" modified="2019-07-31" version="1">MSAPSAYEDDGDRFIPLLYLGTLNSLGKEGIMVIPMVLDAPRCHPSRAEADCLSQSCGHYAKIPDGNLRQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q984</accession>
    <name>A0A4Q9Q984_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_915452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q984"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045109">
        <property type="entry name" value="LSDs-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549:SF38">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLASE 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12549">
        <property type="entry name" value="JMJC DOMAIN-CONTAINING HISTONE DEMETHYLATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="5">
        <location>
            <begin position="768"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="975" mass="108847" checksum="CC63BFA8A990B732" modified="2019-07-31" version="1">MNSMHDPHVHNKRTSINELLNPVSATSSSLGHPYGRQQLPSLSAALQYSQHHHLPPPSQYSQHPPPQINPGPQFSLRAANWESSKDELGPAGRSESDAAPCRYSSSSSAPSHPMYADTYPRHARPVEDTPHYSMEATQSWSSSHETPSASYGAPMMSPVYSDERAAASGEDMSRGAPYPPPQAPPQSHPQYEQEMPPPPHPQPHPHASYITNAYLSYYTHAPPTPRGGPPSMAVHPQNHGPTSPQAYYPAPVNMAFAAIPIAAPPPAMLQQHPKRAPEPSEEEQVGPRAKKAKATKSRAPESSVSSRRAYNQKKRNEAAQGSAQNGKEKASGSNAPSYGAMRIVAEDANSNPDTAGPLQPELQFARCMSNRYRSEEFPRCVSCTRRWAGDTCRFQGIRFFLKNQNRDIVGISFVESQKPDAPTMNFPNKWNINLEMDHIYRVKRTVAVALLPILKQEMQHLSLPEIIRRPRESEVRATCDTCMTSIFSSSWMCRLCGREACAECFEQVKELTTDRVGAPEAEIAALQARREKHAHVNPFFLSCTRRNEHQAKDFSPMSRFCKTELTQAIEEMEALAKRPPAADQESSDESQFRMVKSPPKTPRDVWGNASPSSSSSLAVGDVVKVTESSSFVSASASSASSASSGSSIPSHETITFADAELTDEKFRRAWEKGLPLVVNGLLSKFHLQWTPEYFSSKYGTQSCLILECQTEQNKRVTVAEFFSLFGKYEGRRDCWKLKDWPPSTDFKTAFPELFDDFSRATPVPNYVRRDGVLNIASHFPSNAIAPDLGPKMYNAMASFESQGSKGSTRLHMDMADAINIMAYASPAPDGRPGCAAWDIFRAEDTPKLRKFLRKKFKGQYQHDPIHSQQFYLDSTLRQELYKDYGVHSHRIYQRPGEAVLVPAGCAHQVCNLADCIKVACDFVSPENIARCEILTREFREQNQSMAWKEDVLQLRTMMWFAWLSCVRQEKEMLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA51</accession>
    <name>A0A4Q9QA51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_840402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA51"/>
    <dbReference type="STRING" id="114155.A0A4Q9QA51"/>
    <dbReference type="OMA" id="HGRQGYA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF4">
        <property type="entry name" value="GLYCEROL-1-PHOSPHATE PHOSPHOHYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01135">
        <property type="entry name" value="C1.5.6:_HAD__Beta-PGM__Phospha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="236" mass="25384" checksum="18DD44A2C89B907B" modified="2019-07-31" version="1">MPTVTLEFDAILFDMDGTLVDSTDGVVGAWELFAEKYPGLDVTQVLSSSHGVRTVENLRIHCGVTDPDEQEREARRFEEAIVAESKKNGRHGIVALPGVREIMAEIGPYHKLPKPKWAICTSATIVYASSALKAVGVPIPDAFVVSEDVEKGKPEPDPYLLGAKRAGVDPTRCLVVEDAPAGVRSGQAAGCKTLGLITSHSREQMEAVKPDWLVPNLASVSMKPTENGVQVVINID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA95</accession>
    <name>A0A4Q9QA95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA95"/>
    <dbReference type="STRING" id="114155.A0A4Q9QA95"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="599" mass="64689" checksum="D4B913A86A0EABBF" modified="2019-07-31" version="1">MPDTPITVTPRVVPGAPPPAPVSKSQKKKRKGGAKTKEESEAGSHVAVPDTTSAALIEEAPKESDVKEGIVAPQLVAQPSEGEAATPIGEHKPTPIVDMLNKRLKANGKKITRIQLYQNEPPEKLNEDQKRLLKTLPTLEAVSKELEEVKKAIEIHEAEVAQELAFVKAQAARVQEGRIRDAVAATQAEYLEKTAELVTFLRLLNVLSNGQPEAFTLNLSETEGSVIYSITNTLFHENPQGKSGVIRGIFTGEGDHLGVPYSRIREIQDQFLHPPPPQETPADVSPAFVPEETTVGGVPPSAGPSGEIRFIMTDELAEAEAEAEVEVEVEVEADNQADGTEWVEVAPTENGPTEVEVTETVVEAQINGHTIVEDTVTITTLTEVPAASGQLSWADEDHEELPSLANLQAHYGTSSEASPAPEPEPAVPETPQTPQTNGNSQLVDEDGFTIPHRGRGRGRGFRGERGAYRGERGNFRGERGGFRGERGGYRGGFRGEHRGEHRGEHRGDNRGEHRGEHRGEHRGEHHGEHRGRGGFRGEYGERGGFRGEHGERGGRGGWRGGDRGFRGRPDGDWRGGRGGRGRGRGEQEARAQGGPAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAY5</accession>
    <name>A0A4Q9QAY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_805113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAY5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAY5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000002">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="19196" checksum="99D63B19FDEFC462" modified="2019-07-31" version="1">MSSLSTTQSVVFAVALATSLSAGFALGAWATYRERHAAEPRAPSATKPEPSKNAREDSDEEVEEEEADGDLSAVKPEFLEPCKMVLVVRTDLGMTTGKIAAHHATLACYKALQKTNPAIALKATSEDELLELEAIAKSLNLAARSILDAGRTQIAAGSRTVLGIGPGPVELVNKVTGKLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBM9</accession>
    <name>A0A4Q9QBM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_914096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBM9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="497" mass="54895" checksum="EC5357004822F119" modified="2019-07-31" version="1">MSALASLTTSVIILEFMNISLLLLLVFTPAPKHPIVKALMISCLLRSVLDILPPIVHKIIPQKLGIHITKHPATVNFCIVDSILLNYVTVVKAAFAVNFTLPFLGLALLQAKPKRSADDHPHLTRRNVWILCVSPFLWALPVLLTPIHVLSQGTPKSVQYNITSCYFDDPAFTIVSLIFTLIPLAVSTIVAAVLAVVIWRFSTMLDRTGWHFAKTKRFARFGALVLVTMISASLYTVVLSQWIHLRRRWPDGDGTWTQDTGWVRIIRTSVLWEAITPMLFSVIFAAQEEIYETWLGWISCILPRREHDGNHHGRFGNSLQTSHRVVSAEHASCATLPNRSTTAHDGETAAVERLTPQPIFTRLEKIVSRPLTSSGTRRSYQSERGRQRPRSIPTLDGLTPAPRHGTTEAALPQEPQGPAQSRFAFLKGPSLMTFGSAASAGTSRGITTSSGDTYEVEEGVRPGTGDLQSLSRAYTRPDTPGSWKTFGTEEAGKRPKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCH8</accession>
    <name>A0A4Q9QCH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCH8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7981" checksum="DE9075C60DEE661E" modified="2019-07-31" version="1">MYIARETYRSGLPMTIAVLAAARAVSGGTEIPAAGVCDQSLCRRLYARGKQIMDRGAFPHGRFTRCVREFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCU1</accession>
    <name>A0A4Q9QCU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCU1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCU1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="34862" checksum="5CD2E43E5B4781C7" modified="2019-07-31" version="1">MSCKAAYATLLTTPAYLPGVLVLNECLHSVGSRYHLVAMVTPSLPAEARAVIAKRGIIIRDIDHLYPEEGTHKLTEHDSRFRDTWTKLRAFELVEYDRVVLLDADMIVKRNMDELLEMPLERDWIAAAHVCACNPRKIPHYPADWIPANCAHTAVTTPTSDPPTIDDTSPRPYTQLNSGTVVLNPSLSILQDIVHVISTSPAIPTYSFPDQDLLSDHFRGRWKPLSWRYNALKTLRNIHPSLWSDDEVRCLHYILHDKPWNSPRGTGGDSEEVNGWWWDLYEKLAQEMQEMDPEGWRLVDANVAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCY9</accession>
    <name>A0A4Q9QCY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAR-17a/AIG1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_804362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCY9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006838">
        <property type="entry name" value="ADTRP_AIG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989">
        <property type="entry name" value="ANDROGEN-INDUCED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10989:SF16">
        <property type="entry name" value="AT02829P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04750">
        <property type="entry name" value="Far-17a_AIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="25035" checksum="418A6836ADBB3F38" modified="2019-07-31" version="1">MSATVNIFPFLLHTTAAAVMVYGYLNLPDMVANVPMHNMKGGHFQFLTIQGLCVACITMVLSIGCDLFPFSKLLRAAKRAFLMSALPLAVVISVIYWTLLLCMPHMILMGPPNSEREPSSSTTLPEPERLPLQLDLALHAAPAIALIVDFYSFEDKYTKFVSRYGSLILASALGTWYACWVEYCASYNGMFPYPFLTNSPFNVRVAIYAGASLFAAVSFMVINALHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD09</accession>
    <name>A0A4Q9QD09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent rRNA helicase RRP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_911783</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD09"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD09"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="54"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="248"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="411"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="429"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU65657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="461" mass="50554" checksum="97E91A1B46209911" modified="2019-07-31" version="1">MPSPEEASTSSSPEPQAIAAAPPTFKSLGLIDPLLEALEQMKYKAPTDIQAEALPHALQGRDIIGVASTGSGKTAAFALPILQKLWEDPKGLFACVIAPTRELAFQITQQFESIGSAMGVRCATIIGGVDIQSQKIALAKKPHVIVATPGRLLEHLEETKGFSLRSLKFLVLDEADRLLDMDFGPILDKILKLIPKERTTYLFSATMTTKVAKLQRASLSNPVRVEVNSKYSTVSTLLQYYLLMPLPQKDVHLIYLANTLAQNSMIIFTRTVHDAQRLSIMLRSLGFPAIPLHGQLSQSARLGALGKFKAGGRSILVATDVASRGLDIPSVDIVINYDIPTHSKDYIHRVGRTARAGRSGKSITLVTQYDVELVLRIEQVIEKKMELWPVDKDEVALLRERVDEAGRLAATELKEQGIKGGHGKKRKRGREEGGGKDDMDRDDDVVEAGIPKMNKKSKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEM4</accession>
    <name>A0A4Q9QEM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_803629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEM4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEM4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU66219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="316" mass="34848" checksum="D493E63882ACCBDE" modified="2019-07-31" version="1">MSSAPAFKPFNLALIQLGQVGTDKDENLRHAREMISRAVTGGSDAHPRPDLVVLPECFNSLYGHLHFPVYAETIGFTPDKPYDIASSESQTVKMLSAAAKEEGVWLLGGSIPERDAGTGKLYNTATVYSPQGELVATHRKVHLFDIDIPGKIKFKASHLFESETLSAGNTLNYFDTGKWHEFARIGLGICYDVRFPELAMTAARQGSCCQVLIYPSAFNTTTGPLHWELLQRARAVDNQVFFSMCSPARDLKQSYHAWGHSMVVDPMGTVIAEAGDEEAIVFAQIDPKVLQDARAGIPVTTQRRFDVYPDVSKRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QET3</accession>
    <name>A0A4Q9QET3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_971842</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QET3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QET3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="168"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="220" mass="25593" checksum="7359051979DCDA25" modified="2019-07-31" version="1">MSSHHDYKRRDRSWERDERDRARGGYRGGRRSRSRSPPRRGERDRRGGPGDRRDNYGRDRVDDRRDPRRDDRRRDDRDRKDHDRDRDRDGRREPLPPPRDGDRDRHDRDKDGRPGDRTAEHDSRPAGALERQQPDTPEPSSSRPRQDSAALTEAEGAEEGEAMEATNEDDAAMMAMMGLTGFGTTKGKRVEGNQEGAVDVKKQRTWRQRGGFNRPLDKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5Z1</accession>
    <name>A0A4V2K5Z1_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_659140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="TBU62933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25607" checksum="6D5CC2C487896F50" modified="2019-07-31" version="1">MPYLERLDTHAKAVATFKRKNQQDSFIALLKDVASVVREAYASGTPDLDAIVTIKRVYSDGDLAIIPSFAHAPGTPPVEYSYSRYGKKAIGFGLEEFADRFEHMFVLSSGEHPPLEPNICPAPFRFIYSKRPSEPHYSPLDEHLPSSLQPQSRSTHLPRFCDGVTVSATDPPPLARTIEQARCEIDADNDISLPIAAAVSSALAIATQGGWKHCEPVLSSYLIDGGHEEKTTR</sequence>
</entry>
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    <accession>A0A4V2K650</accession>
    <name>A0A4V2K650_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_835804</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU50953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="268" mass="31943" checksum="302A298D6FD1227B" modified="2019-07-31" version="1" fragment="single">DLDYAIPDHWRVDGARLAALNQKLAYQILIHKKVPKPGSCSDTTRNNIEHTKDEVERVTGIRPTEKQIWKGISKKPIQRKKTDFLWKLLHDRVRCGKYFKHIPGWEDKQYCQCGEIENPEHVLTECELTSEIWDKIAAVWTATAETKWTRPTRGIIQGIGSLRFMNEQQQEMHSDTYYYKVLIMEAAWELWKYRNKAIFEHKARDSEEVFQHWKKSVRTIIINEWETIKLMPFSKQTSRKREFKQRWARDGVARVEKDDETEKLIVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6C1</accession>
    <name>A0A4V2K6C1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_834334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6C1"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10419" checksum="4EB691D51A307DDF" modified="2019-07-31" version="1" fragment="single">CYVPCLSPSGTLSDTALTPPDFRTCLQLDTYVLVLILFPFPSRSPPGPIWPSECLPYLRWNVRFSISVPGATYITSPLSVGIPPPPIRPPPPIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6N6</accession>
    <name>A0A4V2K6N6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_962322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6N6"/>
    <dbReference type="STRING" id="114155.A0A4V2K6N6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
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        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="443" mass="46924" checksum="9980B8BA2C6F648F" modified="2019-07-31" version="1">MAHFPGSPDKTRDVILPKLALKPWVQPSPTSLVLRNARVIDPAESTLLQGPQDIVIENGLILSVTPIGVQPGITPKDPPVVSVDLAGKFLCPGLIDCHVHVTAVPGVKSMAELVQTPEELVHYRTTYVLREMLLRGFTTVRDTGGASRALAEAIAEGLILGPRLVQCGKALSQTGGHADFGPSGSSSGCCAGHSQSLGRTAYELKGGADFIKVMCGGGVASPTDAIESVQFTAEEIQAITTTCKQMGNKHTTAHAYTDASVCHAIDNGVKGIEHGNLISRETAQLMAEKGIFLTPTLSCYGIMVRPPFEDFLPPDGKLKNEQVMSRGLDALKIADEVGVTVCYGSDLLTSMHALQTEEFTVRSSVLPAAKVLQHATTNAANMLGDPKLGRITAGNYADLLVLDANPLEDVRILDRPENHLFAVVQGGRVVSSRVDGLPAESMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6P3</accession>
    <name>A0A4V2K6P3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_764863</name>
        <name evidence="6" type="ORF">BD311DRAFT_604062</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="ML143424">
        <property type="protein sequence ID" value="TBU28151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145228">
        <property type="protein sequence ID" value="TBU53023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6P3"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU28151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15498" checksum="D4297C7BF4924505" modified="2019-07-31" version="1" fragment="single">LGTALALGGAHLRLACFRALGALFTFELTISPTHTLVTAGPYAHVRHPSYTGVYALLLGASAVLLAPGAWLAEAWLRPGAVARMAVLAWAFVSFWVAKVAYALKSTNRRVVTEDRELHRVFGARWEEWAARVRWRLVPGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K710</accession>
    <name>A0A4V2K710_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_83556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145192">
        <property type="protein sequence ID" value="TBU54308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K710"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="113" mass="11884" checksum="478C135D04260B3D" modified="2019-07-31" version="1">MGCCSEHAYHHGTSPVQTAADIATLKQALLALVEHLRQSGVGALPLDAPPIPDSRSDDELASEASKAVQVLYERQKRIQDGASVVVGLLSMGAGVGEQQSSQVSIGRRTGRHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7H2</accession>
    <name>A0A4V2K7H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_883110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7H2"/>
    <dbReference type="STRING" id="114155.A0A4V2K7H2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="429"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="473"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="749" mass="82535" checksum="5374E98B60106DE7" modified="2019-07-31" version="1">MSTCARLPVEVIERIIDSSADDPRTLSTFSLCCRTLLPRSRRHLFVRICIRTFEQMYSVSAFLQSRPWLTPLVGQVKISACSPGPSSAPAALLAVVPLPLLTRLPNLRHWTMAQEWFISKGDMLAGVLSFNRHALAGFEQYGTRIHKLTIRGLQFSTCADMGRFLLAFPNVQSLHCDSCSITRERYGAADHLVRQRLAAKLRLKPLTISASTGKRVVDLPAEISQATLEHLVLCMLTPQVALEEAPVLCFPRLRSLSIDIQIADNYRKQDSEGHVLPILKVVTILKSLTSSDTLICNSLPSLHYFLSLDVGTETCREFDTAILDSSARGTLILQLHSWASCAPQTSGNKFWTSRVEQHFPKLHSRNSLKVQYAPSNPLTSRTLSRQPVAHEDFVTVLTASADGKWFATGSKDSTIVLWDVKHPASTLDWIAHERRVSDLAFSPDSQYLLSVGSDITPKIWDLGGHPGRLVATLDGHHDYVRRCAWANTGTLFATGSYDGSVRVWHGPSIRDHAFQQCYVFTDPRAGPLLQALRFSPSARSLLAIHLPLPGEPDAVPSWRVWHLGADPNTPPKALDRPKTSTFVVAALDSTDRHLVAASRDGSEVNLHALETGEDLMIVTQPAAFSEEVTRVILSPNNRYLLREVGFGGAYDLLDLETHRITALSSDTMLYSPSFSHGGQYIATASNAGVCLWNTSDCSCAAVMKSEVRGLDDSASVLTFSGDAGSLAVGDRSGDVRIHRMEDFVWLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7P7</accession>
    <name>A0A4V2K7P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7P7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="19068" checksum="23CC9DE0220D84B0" modified="2019-07-31" version="1">MRRDRNCRQRLIRPRLRTIRLRLRLINLFRRRNVFTNSSSTIQVSASSFDWNNREIFYLSFPPSALLVLLLWRLSDLRHLPDIPPSPSDISTSVKQQVTSTNQYCSPPLHLTAFRHPRRPDWSLSLFVSVITCSVLSTSHSFLRISFASAQIIDVFMCCCLGMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7Y3</accession>
    <name>A0A4V2K7Y3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_977752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7Y3"/>
    <dbReference type="STRING" id="114155.A0A4V2K7Y3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="555"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="769" mass="85243" checksum="01301F42FFB2F1FF" modified="2019-07-31" version="1">MRRYFSTRSSRRLSTAEVPSEKDVDANSNQPSEDVNDTQTTTEATAVPPAPVAPASLKIKRVDHYWSTWSKSWKYRNTGSGIVAEAVRPVGNGSDNDPWANFCFVVVRKIPEPNKQLEGAEITFQVVVKSPYLLKACKEVIGTVPGLSWTAEPLELDPQLLIAFFPRFEQYEKALHAKARTPEENHMFGAVGVLLEYLRKDYRGTLARIASLTAHGEITFDLLYAILVPRTTIVTECPVTGEPRALQILSATKIVTPMCSLYSLVCESIDSTEEGAHPGRRREKPPTSTRDRLAKLIAARTAKDRRGRAPVSANGNTQTTSSSAALKGRAFGRVQSKIVIFGFKGTEIINTLEAYPIQYHSDPEGLKALLLERGRKWASLKGIHHMLYTGTAALTANVGGSKKLLKYNVDSRVMIDRGNFIRLNPNYEMPKANIAQSAQEQQTQLFWDPNTSTYTSPIDHSDGVPMLDVRTKHQEEEAPLTDEEYILASPILYGFSLSDKVWLEFNVEYVQPINWNEEAFEGLVLAADRKNLLRSLVDVHNADLGFDDFVQGKGQGLIINLFGPPGVGKTLSAEATSEHVRAPLYVVGGGDLGTKAADLDGALERVFDIATSWKAIVLIDEADVFLERRSLHDLERNAMVAVFLRHVEYYRGILFLTTNRITAFDEAFLSRIHVALNFSELSVSAKVQVWRSFLTKAGVSDFDDALVQKLAERDINGRQIKNACRTAQSLAFSRGESLGFAHLGETLDAMEEFTTEFAALDRVRAASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K832</accession>
    <name>A0A4V2K832_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K832"/>
    <dbReference type="STRING" id="114155.A0A4V2K832"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="231" mass="26226" checksum="9E3A1A1257383CF5" modified="2019-07-31" version="1">MFAAARPIGTGMAHPRSLLVHMRGRPRAIACCTYSTSQHKPVNPPLPRFPSPFYSLYRLFLRSAGASVLAEPDSTSTLRGLWRQVFSQATSVMRRFQSSNRPSHNRRIAMNKWLQEWDKRMDSTLELLYCSAITRGLPHQVTRNLSKMARANKDNISPPPYRLEGGVWDGTLPPDHPAYKPGHVKTRRINRTARQRDKDLLVDRPSHTLNEVIGMAEGFGGVSLGRMQRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8B3</accession>
    <name>A0A4V2K8B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDP-fucose protein O-fucosyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_948074</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8B3"/>
    <dbReference type="STRING" id="114155.A0A4V2K8B3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46521" checksum="6BE4205EFA571C11" modified="2019-07-31" version="1">MPPLYRRFHEAELKLPQHDPLLPAPEGRNGRYLWIANHASKCGWGNAMQELFLNAYLAYRTNRAFVFDNYTWSRGESDYSLYNLKPIPSRIPLTALIQGPIAGGHFPAGSGIPRAVTPEYFYEVCQDRAIMSSYEVNDALVDPTAETLVQSWKDKMSPHRCVEIARSPPELFDEHVFADARRLLDVWPHFAQSPIVKEFSWSTLVELAFDNNREVISPTSPFEPTLSSSSVSGLARYSPIPGLLVLHIRRGDFQGHCHDVLARRSIGFTGFNSFPELSDQWHLPEGVSEREKKALYARRCFPEIDMIVERVEEIRRTPAGSGLTNAYIMTNGSPSWVSKLKAALRARHGWAHVASSRDLVLTPEQKYVSQALDMLVAQRAHVFIGNGFSTLSGMAVMLRMANRIAPDTSRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K912</accession>
    <name>A0A4V2K912_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_844440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K912"/>
    <dbReference type="STRING" id="114155.A0A4V2K912"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000158">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="450" mass="50206" checksum="CD724BB6EB8502BA" modified="2019-07-31" version="1">MDEEYDVIVLGTGLTECILSGLLSVEGKKVLHMDRNDYYGGDSASLNLTQLYRKFRDGASPPQDLGRDRDYAVDLIPKFIIASGELTRILVHTDVTRYLEFKQIAGSFVYRDGKISKVPSTEMEAVKSPLMGLFEKRRAKKFFEFLQTWKDEDPATHQGIDLDKDTMSTVYEKFGLEPGTQDFIGHAMALYLDDDYKKKPARPTYERIVLYTSSMARYGKSPYIYPLYGLGELPQAFARLSAIYGGTYMLDKPIDEIVTDADGKFVGVRSGNETVKAKQVVGDPSYFGAGKAQEGGKVRVIEEGKVVRAICFLKHPIPGTDDADSAQIIIPQNQVGRRNDIYVALVSSTHNVCAKDVYVAIVSTVVETDRPEQEIQPGLALLGPIHEKFVSVSSLYTPTSTGETDNIFITRSYDATSHFETVVDDVHDVWKRIFGGKELVLKKRDVQVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MB77</accession>
    <name>A0A4Q9MB77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protoglobin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_468311</name>
        <name evidence="3" type="ORF">BD311DRAFT_72800</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143503">
        <property type="protein sequence ID" value="TBU23508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MB77"/>
    <dbReference type="OrthoDB" id="10027058at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071:SF1">
        <property type="entry name" value="GLOBIN-SENSOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42071">
        <property type="entry name" value="PROTOGLOBIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin-sensor" evidence="2">
        <location>
            <begin position="80"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU23508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="269" mass="30257" checksum="EC1C4E5D2CFD6C4E" modified="2019-07-31" version="1">MEKQFAALNFDTSPEPLVCPFAGDFQSSTRRSSGEDSLTETENSQTPLQSSSTHTDYDTNRQCPVFTQEVDPLLIKTSLEDRIAYLTDFLGFTSRDADLISKIAPSVHDVIPSMVDGMYAKLFEFDITKKVFMTRNQGFDGPLPQTLEELTLDSAQIVFRKVFMKAWARRVLTADYSNGKTWAYMDKVGIMHTGASPFKHQRTMGIAPLNVPYRDIALMLGWIQSILHSAILQIPESVCSATEKVEAVVAINKVLWIQNDLFSRHYIGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MDR8</accession>
    <name>A0A4Q9MDR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Anion exchanging protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_949472</name>
        <name evidence="10" type="ORF">BD311DRAFT_496354</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143460">
        <property type="protein sequence ID" value="TBU25500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MDR8"/>
    <dbReference type="STRING" id="114155.A0A4Q9MDR8"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="559"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="51"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="233"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="477"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU25500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU57340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="631" mass="69327" checksum="402A1C3FE6355961" modified="2019-07-31" version="1">MAMRSTTASVSEKLDAASKQTPPATVSPSPSPSSTSRTRTLPRWVPTWIGRGIIRDVRARAPYYVSDWTDAWNYRVIPAIVLIFFANVLPGIAFSLDLIETTQQYGVSEVLLSSFMAAFVFSVFGAQPLCIAGVTGPITVLNKTIFDIIERQPDAPNYLQFVGWVYMWGAILHWITAALNWCNFLRYVTLFSCDTFGFYVSWVYLQYGVQVVTRQFPSDASSSPPTGSTQSGTSTLDGAFVGIILALLMTVTAFLFRTLSQSGYFHRHVRRFLADYGMPISLVAASAMAYWGRFNRANPSTLPTGHAFMPANDRPWLVRFWELDGKWVGIAFPFGVVLWVLFFFDHNVSSLMAQGTGFPLRKPPGFHYDFFLLGITTFIAGLLGVPAPNGLIPQAPIHTTSLLVMGHAGKADIEAAATRTPSTTTAGPVISSQRPSDDLAVAHTRSRLHRPRTPDLEPDPTHARDGEGDLRRHELPVAVVEQRVSNLAQGALCLVLLTGPFLHVLGLIPRGVLAGLFWYMGLDALEGNGITRKLLYFLRDRALTPADEPLRRVRKSRILLFIAVQLVGFGATMAITQTIAAIGFPIIIFLLVPLRTYVVPRLPFTEEELAILDGPTASPFTMESVGGIKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MUB5</accession>
    <name>A0A4Q9MUB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_819728</name>
        <name evidence="14" type="ORF">BD311DRAFT_122539</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MUB5"/>
    <dbReference type="STRING" id="114155.A0A4Q9MUB5"/>
    <dbReference type="OMA" id="FYNQGAR"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF62">
        <property type="entry name" value="CATALASE T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="13">
        <location>
            <begin position="16"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU58279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="510" mass="57068" checksum="70364ADE2B1E7978" modified="2019-07-31" version="1">MPSAQVFNNKDGALYTTSTGAPVARPYAAERIGKIGPLLLQDFHHIDLLAHFDRERIPERVVHAKGAGAHGVFEVTHDITDLTSAALFSSVGKKAPLTIRFSTVGGESGSADTARDPRGFAIKIKTEEGNLDWVFNNTPVFFIRDPAKFPHFIHTQKRDPQTHLKDADMFWDYLSQNPESIHQVMILFSDRGTPVGYHNMHGYSGHTLKFVNAEGKFHYVQVHVRKDGGFKTFDNETAGKLAGENPDFGIQALFEDIEAGKFPTWTVYVQTMTPEQAEKFRYNILDLTKVWPHSEFPLRPIGKITLNKAPDNYFAEIEQAAFSPSHLVPGIEPSADPVLQSRLFSYPDTHRHRLGVNYSQLPVNAPVAPVANFQRDGFMAFNNQGPRPNYQSSIAPLNYKAKPYENVEHEVFLGTAQADLSEITELDFEQPRALWQKVFSDTDREHFVHNVAVHLVNAKSAEVKARQLSVFAAVDQEIADRIAKAIGVPTVKPLQVKTASEAVRFKFRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MVB4</accession>
    <name>A0A4Q9MVB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High mobility group box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_942134</name>
        <name evidence="8" type="ORF">BD311DRAFT_752839</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NHP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143400">
        <property type="protein sequence ID" value="TBU31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145318">
        <property type="protein sequence ID" value="TBU51469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MVB4"/>
    <dbReference type="STRING" id="114155.A0A4Q9MVB4"/>
    <dbReference type="OMA" id="WRERIKN"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01390">
        <property type="entry name" value="HMG-box_NHP6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000016">
        <property type="entry name" value="FACT complex subunit SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="7">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="5">
        <location>
            <begin position="32"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00064996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU51469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13034" checksum="D6FC312FEBEB9A3D" modified="2019-07-31" version="1">MPKETTKTTKRKAAVKAEKAPKAKGKKDPKAPKRALSAYMFFSQDWRERIKAENPDAGFGEIGKLLGAKWKELDDEEKKPYLDQAAADKARAEQEKNDYDVKKVDSAGSGDGDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N180</accession>
    <name>A0A4Q9N180_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_950170</name>
        <name evidence="3" type="ORF">BD311DRAFT_748141</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N180"/>
    <dbReference type="OrthoDB" id="3365874at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="222"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU33865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="29852" checksum="4E87ACD056276AE7" modified="2019-07-31" version="1">MTRGRRKDMTIPPSRALLQQRDYRARKAQYVADLEVRVKKAEDENVLLRKEIDALQAKLKAAAPLQAQSPYGPEVAAASSDLMHHLTVAAASITRFQQLAFYPGPAGTGPAPHVNRTPITLATPTYTPSPVAPPHAHKLSVSPRIELPPLALSPPHHRHRSAERERELERERQYREPLPSVYPHRSLPATVMGPAPGQQAARFPAPSDPDCCEGYVDCRGLVQEDDESMDEDEDSRSGSRARFTQRMSDVRSTTSSSSGPEDSGSSHTAGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N1H6</accession>
    <name>A0A4Q9N1H6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_929181</name>
        <name evidence="1" type="ORF">BD311DRAFT_350936</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N1H6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU34330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10688" checksum="0751977EF0D3993E" modified="2019-07-31" version="1">MWNGGPRRTLLQDRSPPRELQIDAYKFIPLPASFGQIAVQGGHEFTMGCAVRVLINLCWLFHLEPPLTLKIADLRNSMRLGLQMLNRACLRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9Y9</accession>
    <name>A0A4Q9N9Y9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Calcium ATPase transmembrane domain M-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_938722</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145224">
        <property type="protein sequence ID" value="TBU53131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9Y9"/>
    <dbReference type="STRING" id="114155.A0A4Q9N9Y9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050510">
        <property type="entry name" value="Cation_transp_ATPase_P-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294:SF21">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU53131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="619" mass="66637" checksum="0843429B169B043A" modified="2019-07-31" version="1">MSKRKAIVKKLHSVEALGSISVICSDKTGTLTKNEQTVTELYTVDEVVSLDPTSTTSPNVQVTPALRKTLIVGSVCNNAVRNEEGQFVGQSTDVALLNILSLFNMVDQRQDFTRTSELPFNSERKYMAVSGTHSPSNSLVVNGGQREMYYIKGSIDAILDRCKFYYVSDDSTPALDANTRNVILTKAQTTASRGLRIIALAYGYGPVESTPSSSAPSSHAGSRAGTPSTQLDREKTNLVFVGFQAMLDPPRKGVADAIGLLQSGGVQVVMITGDAEETALSIARSLGLRVGATAAGMSGCLTGQAIDRMSKAQLREIVGGVSVFARTTPKHKMAIVEAFQSRGAVVAMTGDGVNDAPALKMADIGVSMGKSGTDVAKEAADMILVDDNFSTILPAVEEGKSIFHNIQNFLSFQLSTACAALTLITLSTFFGLSNPLNAMQILFINILMDGPPSQSLGVDPIDPQVMRRPPRRKDAPIISQRLVYRVLFSASIIVIGTLFVYIYALADDQDMTRREQTMTFTCFVFLDLVSAVQNRGLGCGLLQNRMLVTTVSTSFLVQLALIYVPFLQSIFQTEALSLSDLCTLFILGGFSAGLHEARRRYERSMNAAESYSGAVEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAV5</accession>
    <name>A0A4Q9NAV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAV5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="202" mass="20414" checksum="B2BC3F3E2B9E6E93" modified="2019-07-31" version="1">MRSVFATAVALSAVAASSAKQIVITVGGNTTNNASTVFQPAEVTANIGDVVFFNFTQGNHSAIQSEFASPCIPAHDTNITVNGFNSGPRDAGNGTAITNLPVTVTDNNTIWFYDANTCAEGGVGGINVNESSTETLDGFRRNAIRLNGTSTSTSSSLSATRTGAGSSSTSTSSVSSKSSGAERPVALGFAAVVPMIAAALLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCL4</accession>
    <name>A0A4Q9NCL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-Glycosyltransferase/glycogen phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_820902</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCL4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045:SF34">
        <property type="entry name" value="ISOFLAVONE 7-O-GLUCOSYLTRANSFERASE 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48045">
        <property type="entry name" value="UDP-GLYCOSYLTRANSFERASE 72B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00201">
        <property type="entry name" value="UDPGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="476" mass="53654" checksum="2F60F641B57B6E27" modified="2019-07-31" version="1">MCTLVARIVRLRPTFIVTFFVVSGFYDRVKGEIARDFLRGEEHMLSRIRRVEGVHDTSSAEDAFETAYRNIIDDKSLTCANTGTTFDPHPVRPTVAILDMFVVRAFEIVKTLSSNTVKVYTWYPAATKSFHYYFAEDLVPACEAEAASRGMSFNDVAYERFSNFTGRVVRTPCAPTMHDWEYNPQATRSPREFIGNILIKVGGQMKRTDGFITFDAAEYCPTATESLRSWFAETGRKCYYAGPLVPQQKEEPLGDPRSYQIKTFLDQELASHGEKSVIYISFGSMFWPTEPEKLWAVFDVLMERHIPFILSTSAVFAKTPPPEVQEKVAQYGDAMITDWVPQQYLLDHPATGWYLSHGGHNSTLETILAGVPNIVWPVYADQPVNAIHLSEDLDVAYELFEVRCGTGLGQILRNGKTPTGTVEAVKAEMHNVLDHAFGDDGARKRVNLQAVRKKLQAAWAEDGIARREVEAFLDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NH10</accession>
    <name>A0A4Q9NH10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1042457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145216">
        <property type="protein sequence ID" value="TBU53359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NH10"/>
    <dbReference type="STRING" id="114155.A0A4Q9NH10"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23978" checksum="ECB7DD916D42B2DD" modified="2019-07-31" version="1">MVSALRLVKQFRVRELAPVLKAADPQLSTTRPKVRNPFLPFKNPDTGRWAPAKYSLRRQAELVKNARASGTLHLLPPGPKLSHKELPAASQTVSQTVAAPANGDAVVEGEILVTDAQLKGQPWWSGQVEWEGEFKEKEVKGADVGNRLYAGRKRMFKGHKWQRTQQEREREQKMLLKDMKARIERFKTTYRRKTPSPISPARPVSYSKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJ93</accession>
    <name>A0A4Q9NJ93_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_829393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJ93"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6534" evidence="1">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="187" mass="20728" checksum="BFFCFCC89E842497" modified="2019-07-31" version="1">MSADAGSGLSGERRQIEQAYLISFLGLSFLLNIVLTWRLVWYLRINHTGVKSTDNLINRIVSFSVNTGMSSLILTLAPMILLALPMRNGLAWYPVMTLLAPVHTSIVLVAVNSRRSLVDRGSEGIELRSFDLDVAPRRPELNSTIEFAEMGGGTSTTIEIRDAPVIRVDLEEQPPHEGSPKDRRDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLV1</accession>
    <name>A0A4Q9NLV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_826568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLV1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6395" checksum="804FA6C758477584" modified="2019-07-31" version="1" fragment="single">RSDPLGSDPGSSQGDINVGASGHVNRRVGRPFATHCSSELACSGHELFFPTAHWQRLGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNA7</accession>
    <name>A0A4Q9NNA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_646374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU56020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNA7"/>
    <dbReference type="OMA" id="YIPLCCL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="360" mass="38989" checksum="30D6478834C8218D" modified="2019-07-31" version="1">MSSASAPAAVFTPPPPGLNYTAALDPSIKFLLIGTACSATLIPIAVMLFFFSTPSGRRQPVFILNVFIIALGLAEGGVNIYNQTRSMLALPVSVELSIAFACSSILVPALADTVLLLRVFTVYRPSQMTTKCIAAIYGPISMVKIARMVVEIVFVVRWSRAIAGGAVGSNILIVGQIAWRTPYVKAAWVLQLADSSFASAIFLFRLRKGRLRTNRIHVPGADNDTNISGTTQNTYYDRLRTLFWISASNFVFPVVLDLTLLVLAFSEDNFLTGTYVLMVSNYVDIIGVLLATIWSTSTKYAQPLMPGGEVSEFRTTRSLSPPRFAVSVTTVEERLDSPSSQDIPMTVFKPAGTSGAHTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRF3</accession>
    <name>A0A4Q9NRF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRF3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NRF3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009686">
        <property type="entry name" value="Senescence/spartin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045036">
        <property type="entry name" value="Spartin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21068:SF43">
        <property type="entry name" value="SPARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06911">
        <property type="entry name" value="Senescence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="965" mass="105070" checksum="BFA3C5485D5FE6E9" modified="2019-07-31" version="1">MPLEAQFLGLPGELLVECLKHLDWEDLVRCKQVSKRLRDVVNDSLELQYRIELGADGLVEGLGCTYTTAERLQLLLQRRARWRYLDWSRIVPISAPGLCQAYELVDGVFASSMGNDFFGSRHLELTWLPTSTQEARKIEREDLGIRIRDFAIDPSQDLMALVLADDVTSMTIHLRTISRNEPHPKARIPELRATVPQVRNCFVQIVDDVIGAFFWFHGPGLVIWNWRTGKKVVDCVGVNLPTGTYDFAFISSRAYIVTVTMQYGSIEVYTFSGGDEDAETLSNTVPQSPSLGDRLLPTRVAIFRLPPTKPGQDLRRFLTHSAPFVANPTPGRVFEVSRDARVHMMCLYYGDHAGSYHLFLHNRFLLAHIPPGIGSGAVGKVTAVAKEWDEWGPDNARFVNWIAHFQWLRRTLQLTTQSPCARYLHGERVIFPPIPLALRQPTGDDEVKMVMLMIDFHVHPKRTDDPVKPPLELDEAGGGYEIVARETVIDSGAVFQHPVVSRLPYAMSTRSGVRGLVDYTGFMIDQDQLIAMKVNAKHTQHFTMSALITIPGATAHHVLGQSNVTLGAGELNLVPASSDGKDLMLTVGSAGFTLHHGTAFGTLEGDPRAYVFNPEIEGLDGGFVKITLPEGVTEDGSQLSTLQTKFEEVLIAHGLLQPSADDASREGTGAHHAVQKLKSAIHSDFQESLVDIPGCVVAQVLGDEPNILSKGTLSLFGMIKSAKEEEPVLTLVIGKSAFPLQFELALIDHGLLKDGFEAAADEVARSVREGSARVAQRVRDARELYLRTHPRTTEPVVFHPAAQNMAGSAERGTQTLANIAHGVSGSVLGAASVAGSWFARTFVPTEPKVTERLNSAARGTMDVAGGVGAGVQDVKDALEHAGCEVIENDYGKEARVVVGNVGQSVGNVGAVAADAATVTSGGPVLAADVIGAASEQNKELRKRDIEEVKADGVPEESDGVDTEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUQ2</accession>
    <name>A0A4Q9NUQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUQ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7305" checksum="B0322C3F37CC49D7" modified="2019-07-31" version="1">MANGGGDLRTWAVIGLAVFRVRQMVDRDTLEAPMCDVSVVILTHYENEAEERRPDSEGTGMPRGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWB0</accession>
    <name>A0A4Q9NWB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_915630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWB0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NWB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="536" mass="61195" checksum="0E88F0CF20D29A15" modified="2019-07-31" version="1">MQLLVLVLLFALAAAIRIVFRRRYRSLSHIRGPPSPSWLFGHDIATVRQQEVGELDFKWVKEYGATWRIASHLGTQVLMTADPKAMQHIFHKSGYNYAKRRDHTEVTKMFTGPGIISAQGEVHQRHRKIMNPAFSAPQLRSFLTLFQDIGTKMCDKWKTEVLDSSSGTVAVNKWLARTTLDIIGEAAFAYDYGALDERNDRLSSVYNNIFLKTSLHPSKWLVFWRSMWNYFPDSLLRYVQYTPTAEHRHMRHMTRVFHEVSSEVLDELTGGISDEDGKKDVMSILVKANSSEDPKTQLDYVEMTAQMQSLTFAGHETTASTLSWMLWELAKHPEYQAKMREEIRATRAAVLARGETRFTIDDLDSMTSVMNAIKETLRFHPIVFGLWREAVHDDVIPLSEPIVSATGEVIDSIPVRAGQWISCSFCAYNRLPQVWGADADTWNPDRFLHIDLTKQVRVGVFANLMTFSAGIRGCIGWRFSVIEMQALAAELLERFEFGLPEEHYEIMRVPAGLMIPLVKDKLELGAVMPLRVSLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NX59</accession>
    <name>A0A4Q9NX59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_911093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NX59"/>
    <dbReference type="OMA" id="LTCIYTY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="520" mass="57058" checksum="8727E97170175176" modified="2019-07-31" version="1">MSDISDDDLADNYGPTTPAPVHTKAAAASRARAGGASGKPVAGPSTKPQPKAAVSKKGVSKPTNAIELDDDDSEGVVFVEEAQTKKQRKSSEAEVVAMPGPTKGASKKAPVRGASAVNGTSKAAAAAAKGKARADPSPADGDAMEVEEDTAAQVDEEGSAEQPPPRSGVRGGSKQPLLRGKNTMTAAAASRLAKENQRLLRDMDRLRAELEQMRTNNKEREKLQERLEASFDEMIQRRTTDAEEIKNDVEARHKEEIQRKDSLIQELTGQLSKQSPSSSSQSWTLHFLTREAAEEEKRALRDENTRLKDVIKQHNAVIGAKDQQIADLKQEVDLTKKELQAEIERSNQLASRSATIPASVVPNGTKAVRGPANNLPVIKLYEDMTNVLVTSVQKEPSVDWPGIDEDVISCIYTYENKDENITFSLNFMLRNQFDRPENYSGKEALPKDKLVEKVKYIPRNLELERPDYVERLQFFKEPFMFARDQMTVFLKTLTDTVSGIFESEDGGDEPGGADEPIVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NY34</accession>
    <name>A0A4Q9NY34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_804443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
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        </source>
    </evidence>
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            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU65293.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="372" mass="40748" checksum="71E7DEA7FF6F5C03" modified="2019-07-31" version="1">MAPDPTPIPGHKAVETLVAKLRRRQIVGSRQAALETVLVLRQVVSKARFSNIQQLIVIIREAGRRLVEAQPKEHTVGNTVRRVLHNIREEYHSAVKVSAPTSSRNVYTISKFVLQGQPRKQTVGAPKSETTATLKEDDPDDPDSFARGIKPILMEAIQDVLDELETVYDNVSKTAKDHIHSDEIILTIGHSRTVEAFLKSAGHTRNYTVIVAETAPSYSGHDMARALSAAGISTFLVPDSSIYAIMSRVNKIILGAHAILANGGLVAITGSLLAATAARAHSTPVVVCAGQFKLTPLWNLYHDYGALDFADPSSVLGFEEGKLVERVDVVNPYYDYVGPELVDVFITNDGDHPPSSVYRLIKETYDDDDHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYL7</accession>
    <name>A0A4Q9NYL7_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_922477</name>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
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            <end position="1664"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU60689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZL2</accession>
    <name>A0A4Q9NZL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_929554</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU57363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15469" checksum="39704BB89EA7D359" modified="2019-07-31" version="1">MYDRLLRRCVCACARCPLQDMHRTMLSRYANTHAAFFPCAGARPGFWPVPHYFQAAMPRGTLRPPSDETRDVVNRRRAPCAPTPQQGRMTAAFGPRPASSARARSAERFFRCRTSRPQARERDATGKASDITRTGPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2Y0</accession>
    <name>A0A4Q9P2Y0_9APHY</name>
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        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU53409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2Y0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P2Y0"/>
    <dbReference type="OMA" id="GTHVKQD"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="90"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20990" checksum="488E35B4E4B79B5D" modified="2019-07-31" version="1">MSLDTYAPSLDYTPTKPSSVLFQGDIPAAVQRQIVEFSDFHLKGVDFARTTGQRLALKEASVFRRPEDAKLQSRLVYELTVAQDMTNRQHTLHGGCTAFLVDVCSSVGLAFLAMVQGKPSDFVSQTMITTYHAPAPVGAKLNIVSTTTSFGARTVASRIEVWDVTHHRLCVSGVHNKMAPKMPTPTPQNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5Z5</accession>
    <name>A0A4Q9P5Z5_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16873" checksum="EC6A98198D089C6A" modified="2019-07-31" version="1">MRCRHASESCHLMCNRPHPHLSHPSCRTSASGYDVARAAVRVTSSGLNYTARQGTVHLYCIPPTTQRNPKPSVSAYAPCVADQVVHRAVVCVKLTSSVRVAGSKSSEPLWRPFAWRVLLGPLRQSYPYPHALLCFFKPATCVSLPNLRHWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7J0</accession>
    <name>A0A4Q9P7J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_6917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU65406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Prephenate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050812">
        <property type="entry name" value="Preph/Arog_dehydrog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012385">
        <property type="entry name" value="Prephenate_DH_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21363:SF0">
        <property type="entry name" value="PREPHENATE DEHYDROGENASE [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036510">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
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    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="475" mass="52926" checksum="570137B73BBB6CC5" modified="2019-07-31" version="1">MAIGNLVRPDVTPDSPIEEQPSIGLIGMGAMGNMYARCFSEAGWKKIYICDLPSKYDDLKKKYEGFPGIHVLKDGHLVSRISDYIIYSVEAEYIDRVVAEYGPSTKMGAIVAGQTSVKAPERAAFEKYLPEDVNILSCHSLHGPTVSPVGQPLVLIQHRATDDTLKLVEHILAPLRSRYVYLSYEDHDTVTANTQAVTHAAFLTMGTAWHCSASYPWEHGMYVGGIETVKVNIMLRIYSNKWHVYAGLAILNPSARVQIDQFARSTTEIFKLMLACDAAGLRARIYDAREKVFGEYLQDRQNAADGNGHGAARPPILLSEDILDRFSLGKKPAENASPITTSRGNPPPNSHLSLLAMVDCWAHLGIKPFVHLDLAATPIFRLWIGVAEYLFRSERRLDAAIHAALYETTHRSDDLEFVVAARGWSQCISFGNFELYKQRFMQTSAFFESRFEEATKVGSAMIQALMDTEDKAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8P1</accession>
    <name>A0A4Q9P8P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_976837</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8P1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P8P1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="807"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="346"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="4">
        <location>
            <begin position="419"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="851" mass="93664" checksum="F7EB150DE39CE047" modified="2019-07-31" version="1">MTDPPQPKPGQTMRADARGECGACSDADGRAPSEEGRGTGEDRREEGHEAAGRGRNRAHGRESPVAAAAHRPRRRPSPTLGPTDRSPPQAHARSQAHHRNPHTSIVRAPASPPNAAPTSSLPSVPNVPHARMSSHNLLPLLQCPLCPPPSLLHVPLTLHCGHTFCASHFPPHNKPSTSKEVDIPPALPHCPLPTCCPSSPRYPATFSRTPPIDVTTNKLLELVLRASRDDLQPDSPPPHFSDDYEDRTDSEREYDSDSDLEYLPLSPQPPSFPGTPSTTRGTNQPRTGSSRSRSPPEASPRLHPRKRRRRLCRRAAGPSRSQAQPHRNDHDRHTQLEKELLSELTCEICFGLFWQPITTPCQHTFCTRCLFRSLDHNQTCPLCRQKLPGYDYFQQHPCNKVILAIILRAFPEAYAERGQAVEAEERDARLDTPVFVCQLGFPGMPTILHFFEPRYRLMLRRCLENPNPCFGMIPPPRAAPSTSANGSVSTGNDYGIMLQIRNVQMLPDGRSVVETWGTWRFRIMERGMRDGYTVARVERIEDYEDELDDRAFAPPDEEVRSMNGDSEAIAAEGGSVAYSGSRGQEDLQSADSRVVERAGDQAEEAPSRVEIGDVMQAESELPVASSEVALDVGAGAIAPPSSHPPRIAADHRAAARPEDATPTPSPAGERQPNGKAPAALRPPTNAELMAKCHAFIDQTRRGTPWVVQHLHNNYVPMPSDPASFSFWMALLLPIDEHEKAKLLPIRSPRLRLRLVVHWIEHLNSQCVSSPVPISPYLVSSTRAYASASALQVVLWRVRDFLMLPRAVRVWAMLFAYAALLAAIYLGQSVAQRPGSSEGGASHGASERGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P994</accession>
    <name>A0A4Q9P994_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_983135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145549">
        <property type="protein sequence ID" value="TBU50948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P994"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU50948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13537" checksum="6A30BA5EA3296E91" modified="2019-07-31" version="1">MLETASNIIVPDQGEAWHRLRREDFSQVELDATPELWDLIKSMMRTAPALRIGILLVDAHPVVVRARRAMERIRSRYGAVFGASPLGAVPEGFLDEILARGRHGADDADEDKDDWEMDLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAR2</accession>
    <name>A0A4Q9PAR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_972161</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAR2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAR2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000440">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="230"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="12">
        <location>
            <begin position="681"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU66182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="890" mass="98019" checksum="E0F84A0D43F6CDB6" modified="2019-07-31" version="1">MAPKADWEKWDKKVDDKEEKEIKPLDDSDIQILKTYGQGPYAARLKKIDSDIKEVQKRINEKIGVKESDTGLASPNLWDLAADRQRMGEEHPLQVARCTKIIPMDPDAAERARAVNPEGAVQGQKGADEQDKYVINIKQIAKFVVGLGERVAPTDIEEGMRVGVDRNKYQIQIPLPPKIDASVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLSPERFVNLGIDPPKGVLLFGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARSKKACIIFFDEVDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALLRPGRLDRRVEFSLPDNEGRAHILRIHARSMSVERNIRFDLIARLCPNTTGAELRSVATEAGMFAIRARRKVATERDFLDAVEKVVRQGTKFSSTGLIFNPEQSTDSPLSPVELSRLMEQHARQPPRPLTLSKLLSFARPLTPDSVLQSVGYVFSEIPRMLAMRARALEALPFIVGMNPYIARTLQSHRRAFQFLVTHPPVRTLEENALLIENLADLVRSHADDIPAMAKGFQECARYLTPEQISEFLDNAIRNRIAVRLIAEQHIAISRDLAQGDGASNHLGVVDLACLPKELIGVCGSFVKDLCEATLGASPQIVIDGDADATFAYVPVHLEYILTEILKNSFRATVEWHQRHHSHSSPARVPPVVITISKTAHPDALFPPSSQPPSKSPFPISSLRTAERPSRFLFLRVRDQGGGVSPENMSRIFSYSFTTAGRGAEMHWEDEGMGGGPYAAQHMSGAGAIDGGAGGESLFSEIAGRGVQMGMGTIAGLGYGLPMSRLYAKYFGGSLDFKSLDGWGSDVYIKLRCLDDGGDVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAZ1</accession>
    <name>A0A4Q9PAZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_803359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAZ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="411" mass="43338" checksum="0D8165BA713D1E40" modified="2019-07-31" version="1">MENQGETPGYSIDTAVTEPSPHAHPDGGLQAWLVCAGGLVGTCATFGLVNAWGVFQAFYTEDILLGTSPSTIAWIGSVQYALVFLPGLIMGRVFDLGYTKMPLIIASALLVAATFLTAQCKEYWQFLLCQGIATGLACGCIFGIVIGTPSHWFKRRLGLALSITAVGSSVGGTVYPIMVKNLMSEVGFQWTMRILGFLELVLCIFTRQTIERRLPPRVSAGPFVNLAVLKSLSFTLYCVSSFTLFLGLYTVLTYIDVSAVGAGVPDSLAFYLVAIANACSAVGRITGGILSDRAGPLNIMIPFLVLAGIMTYIWPFVTTTGGYIAIAVVYGFASSGVFVGIMTSPAVRMGDMHDVGSRVGISMTITALGAVAGPPISGALNAAGGTFKYTGIFAGASQRGNPKLHFVDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC52</accession>
    <name>A0A4Q9PC52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145256">
        <property type="protein sequence ID" value="TBU52319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC52"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="7038" checksum="A14DFD401B2E7F38" modified="2019-07-31" version="1">MARYQPHFSCPLFSKGSVVVNRKYVEDESFPRRLTLPSRHFVRGKECHRRSRGFEGELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCT4</accession>
    <name>A0A4Q9PCT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_910099</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145251">
        <property type="protein sequence ID" value="TBU52428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCT4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="555" mass="60738" checksum="053FCB91DAA4E31F" modified="2019-07-31" version="1">MARVSGPMGKRDLRRGGFPRTSILAQGFGHPVGTPDPPSNNVQRADLQVPVNTIVATTLFTSSILLTGSTSAFACAYTDPPSFLPASDAAASLEDHASLSLYRPPQRHQFKATTPTAADAPSSYPNLLSRTQSAGRTEAHEPMLDERLRICDCSWMYAGVGPRSATARAMKAGKRRIVLAHCPAANARRGTAHAAGMQSAQCTSWAAPYPPAQNTYLALDMHCSQHIILGILCPDTKEPFMDDCKSARDNRTSSQTQQGGLQGWQSGSRTTGSAGPDGLARRRPSPSPICCDLWLQVLFFLTFFVLVVVVTCARQPNPNYVGICASRRAVPQSESVRFSKMGAKKCTKTDSVIGIQCPDCAHSMSLSSMSGYDSYHPVQLELEPAIVVLKAVIARELEGEEPLSPPVALKAAIYEPYCENFDHMLKLFLHKNPIISMVGVNALTDPLHVLLRSAMQRRRSGRRRASCGEYTPKTPESFSPRKVIHLPLTYVYVVLLPSGKGDTHFLANCCRLMYMIKIIIRQLIVAAFLGWWLLETNVMRSEYEAERKREGGDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEM9</accession>
    <name>A0A4Q9PEM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_834161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145311">
        <property type="protein sequence ID" value="TBU51532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEM9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16709" checksum="C4E88D6F8E7F90EB" modified="2019-07-31" version="1">MASAGEQIRIAIALAALRHKPPLQSVHAYILDLHAAFPPPPSTASGERESHRAPSPNPWRDRVLVLESDLRELQAQHDKDSIRTSPPALFRQQRIRVMSITKPRSGGLNPSTPLRAFLCVSPIPAMRIFPDCLLGDVLPRCQTGFSPCTAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFB4</accession>
    <name>A0A4Q9PFB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_941356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145279">
        <property type="protein sequence ID" value="TBU51887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFB4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU51887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="23518" checksum="38B40E65322E6BAF" modified="2019-07-31" version="1">MFSIRDKAVFLLLLGFGNLLYIIWIGRHLRNNHTNLHQQPYSYRGHDYPEFLPLPQLEDVYVVMEETVHYLPLGEKSEEAWHSLVPAGDGYVRLGPDNRTFTTTMFHELHCLRMINRAFSRSPSMTMDHLRHCLNYIRQGILCSPDLGLEPGKFEEKDYEVERTTGIHICRNWDIIYDYMDANYASWSGGRDKVVRLDEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFD6</accession>
    <name>A0A4Q9PFD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFD6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14976" checksum="9F91AEA153523FFE" modified="2019-07-31" version="1">MTNTLLSNRGLRSRDQTFGASSGNEKSEVPELLNVFTPVTPPSVTDVTFPLVTQLPFARLEEHPSGWGALFDDDNDNDNDGYAPFECDSDRLLDVSEWGLIKAVLEDPARPFTLQHLSHAQAPNPTSFCNVHLPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFU3</accession>
    <name>A0A4Q9PFU3_9APHY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_127221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
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            <end position="74"/>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="15224" checksum="459C29C9F0893238" modified="2019-07-31" version="1">MPEALCSMVDVSAENLPKIFIKVYFGGKEHHCAILEQKSGLRLKHGLVERSPCERPGHVRNRNSRRSRRGTDRAKQDFARFRLQSFLQSTVIRPSACVMHDAVYAHFLQQHSDTLVSMISKMASTEFPVNEGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
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    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_260571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU52101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="84" mass="8990" checksum="3FE58A14AA75DD8D" modified="2019-07-31" version="1">MRDISGPGVAARGRERVAMGVLFRPSSLLGSSPPTALLMHLSVLTLVLTIKERSWWIATPVLPKVSSLDDSTIPQSSYTGLDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGM2</accession>
    <name>A0A4Q9PGM2_9APHY</name>
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        <recommendedName>
            <fullName evidence="2">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_829701</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        </location>
    </feature>
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            <begin position="312"/>
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        </location>
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        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="345" mass="39189" checksum="C6C382232EFD6A57" modified="2019-07-31" version="1">MIAPNLSFLSNACGVRAVPHAEVYRRLQLPQLPAAQYIPTPHGIQMQIPVISLPHCFADTAVWYTEEIPQPQWYLAILGCEHSELPGALLGRVCYIPPSDSGVEYLYCKNLDIHHRDYSLLSGFSLVPLSPTIIARCRGSILLKTVYISLPALTGRPSHSFNEDFNETINLILRKKTCDALRTEGYTAELQSPDPSHATTHCLTLSRLRESYKITIEYQHTFAPITHELRIKAYASLSWPVDHSVEEIEAVPSFAEWQSFVAPWQWTSSTEKLAFFLGTSKITVELGFHYAGQSHYFLHVVIDRSRELSEDERREPWETWQPGPDFRPSPPPSPIVRIVHDDLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGN6</accession>
    <name>A0A4Q9PGN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
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        <name evidence="3" type="ORF">BD310DRAFT_981947</name>
    </gene>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145256">
        <property type="protein sequence ID" value="TBU52331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000292082">
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    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="30"/>
            <end position="52"/>
        </location>
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            <begin position="64"/>
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        </location>
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            <begin position="180"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="184"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="38973" checksum="9832467627E6EA2F" modified="2019-07-31" version="1">MATAPHELTATILAMSDRAAFPLPALDNTYGALLLGTFIGLMLYGLTVHQTYRYFRLYPTDIPVLVYLVLAILTIETVHTAMIMAACYYHLVSNYFNPITLLEGHWSTRIITPTSGLCILVCQAFYARRVWYVGHQYRYIVGVAGVLMLALLAFTISATVEGFILPLSNFHRDSWMVSVLFSLAVAIDILLTSSLIFVLVRSRTGFKRTDFTIDIIVVYAINTGLLTSIVGLLGAIFAIILPGNFIYIGISIVATKLYANSVLAVLNSRRALSDRMLEGFEMGSYEPRGPRARPHTVVDTWDVPQFPVDLPSRDTHISFTTPTDTNSDDTASGVRGLQAKSVLSSEALTVKMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGT8</accession>
    <name>A0A4Q9PGT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_910444</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145284">
        <property type="protein sequence ID" value="TBU51806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGT8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU51806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17118" checksum="A4E7659850C76BDD" modified="2019-07-31" version="1">MVFPALAPLPVSRTASALAFFSFSRTFAQTWGVTIGSTILQNRLDKTLPAQFGTQFPSGVQIAYAAIPVIDNLEDPLRSEVRDAFAKSLRVVWLAMIVMSGAGLLSVGLMREVPMQKTTDGTYGLDVISHPPLPDAEKHGGAGVSESAATQRTEPEVSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGX4</accession>
    <name>A0A4Q9PGX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_889129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145243">
        <property type="protein sequence ID" value="TBU52622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGX4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGX4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="5">
        <location>
            <begin position="39"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU52622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19334" checksum="B807EBB590C0BA5A" modified="2019-07-31" version="1">MPVCAEMHVQLSLFTTAMALTVQRHMTDSEAAKMNLVDLASNIALTGTEGPADWYMDSTALLADADHYRGTQGLIGDFITLFSWRLCSDPPSEKYPYGYGKSDIIGKAVPSIVGEHVHVHSHDREGRGDGLLDPNAAWLYRCAIRVADEERSPILLVNAVHESDVFGSAVALVAILGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH42</accession>
    <name>A0A4Q9PH42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_939301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH42"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10554" checksum="B23F6572061668EF" modified="2019-07-31" version="1">MTRGTASVLLSQFFLDLQAASRCSLKLELGTDDPLRFSISTDALRSMLSLSFAEPIVGPMGDAYIESYTDPGARGRLLQLSGPHERPECMNTDWQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH61</accession>
    <name>A0A4Q9PH61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_831342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="37022" checksum="C58604C64C7B40CA" modified="2019-07-31" version="1">MSSTHLPDSYLDALDIGKESRAGALALLVYDHLVTLDLEAELVWTQSKRSRVVWLYIFNRFFPLVWLVCIIYLSVDDFVILVSTLAVQIILQLRVYALYDKGRRVRLFLVCCWLAEVTVMAILIGITMANISGKCRWCSPQARAQPLMLVLADLPVVSTPTGCYYSGIFSISALFWLPALVYEPILCLMVLWQAWDQDWTSWFRRAVDRSGTSVRLHQGRLFKVLARDSLIYFVAIFIELIINTVIWSHYNRYINIVVPWAGVLPSILGSRLLLSMREAIRFSEQYGPHATAITNLAEDRTAASSTMWFATVDQMTIIPRDKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHA8</accession>
    <name>A0A4Q9PHA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_201607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHA8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="18522" checksum="C3C3ED62FFF3EBB5" modified="2019-07-31" version="1">MLFIGHHDRMFNAWTTPSHIPTDVSLAPAGSLYRRTLVHSIIASRRMYHLRCKLPVTSLPTPLRCLVELSCIQYPVLRCSRATRRFHFICADILYRDGRTGGRYIHAGSCPSSHQYHPFVTCAFRPRRRRLMGSMHGDAISLPLLHRIASNHTRPRLASPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIC3</accession>
    <name>A0A4Q9PIC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145225">
        <property type="protein sequence ID" value="TBU53096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIC3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13410" checksum="F529FFD4F220AB05" modified="2019-07-31" version="1">MTVPEYAARFNELSTRTGYSKADLRDRFYEHLVDSIKDELVHTARPIASLDDLITVSSEIDVRVRQRRAERDRQRGRTTTPTTATKPAVPLHATPFTPPTRDPNAMDIDATPDLSVTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJR2</accession>
    <name>A0A4Q9PJR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TRAPP trafficking subunit Trs65-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_936182</name>
        <name evidence="3" type="ORF">BD311DRAFT_766700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143481">
        <property type="protein sequence ID" value="TBU24390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJR2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJR2"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="907"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="732"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU24390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="977" mass="105939" checksum="BF13802DFA19E09A" modified="2019-07-31" version="1">MSSYEDLFESSVLEVIAPPPSLEFPSEYTGQKASDWIARLREPFADRKTAFFDENMDFFLTIRFPSLSEEEDPATDSTPQPPSHLLSFLAHLQISYETSYISPSATGSESTPGSRLSMPPPRNSSMQRNRPNALLGGPSSIFPPHTPHPIPSAAESDLKYVQSQGTPLVSAIWGESENRDKEAFALLWDASEQLWIAMYKMTILVLFMVTKVPDPLLCITVSTTLRNKPLAVTPPRKALSALIDAAGGLNSELVSSPVKENGVDHDSTHSDDDEILSGLQEVNLLEGLAAGPTFTDPHKRLSLPSTRLGSTTRQHAFSLAPAPNASSSDTPVPYSGGVISPPAGGSISSLSSLPKAATLRKSFRKTLNTHMGFRVRMRTVFVPYFLLPQDAPNGITQKPRRVKDAGLNASDSDSDLDDDILEEREQREAGNEEHTVVLSVEVENLFAGSSPGSYHIEVERVDVAISGSGARASFIGWGGRTTDVFPLQVGPREQINLLYAVSFLRGPEVDEFSLARPAGDRRGGPTEELQRAVTIHLIVRPFEPKGGEAFYPTHPFPSRWNCVLDLASSSVLKQRHESGEAEEDGNQEYFVLPTPASPFPTAPLAPPQRSLTPLTTKHTIPLTAIAGSKRHTIAAFDTPISDYARMPKSPMNYQSSTSMLNPQNQPPAPPNSSPTPTGPASGQTLHIPSRTSYIPPSVSFQTTFPRSPTTYAPPTSPPLPPPPSNPLAAYAQTPSDSSSTVNEMFDFTIPRTPAYPAYPSSPAPVPPTPFWQTPIAQQSGPGAVGPSVEIRRERGGNIPQTPGPTVGGFGGLTINPMNALQQAGETASIDGSGEAVVVSVGLLPSPGRAGKKPHTGELYPLDQFTLDIFVFNQSSWTRRFEVSYPEERRRRRKAKERGDGLREVRPPSIIPLQNRVRIGPLLPSTCQSVRMDFLALAPGVHPIDTLTLTDIQSNFTMNLRSVIDIIVHEPKIKETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKX3</accession>
    <name>A0A4Q9PKX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein ROT1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein rot1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_1031751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ROT1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKX3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKX3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006458">
        <property type="term" value="P:'de novo' protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019623">
        <property type="entry name" value="Rot1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28090:SF1">
        <property type="entry name" value="PROTEIN ROT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10681">
        <property type="entry name" value="Rot1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020482644" description="Protein ROT1" evidence="10">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU54823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26164" checksum="CD1131175D24779A" modified="2019-07-31" version="1">MFISSILAVALAAIPAVLAQDYSAAHNVTPISGTWSSGSKKVITGAGFANPANMTFNYPPVTGVSYAFTDDGFYEVARYRFNGNGTSIARIGCAAFHGDRSSPNCITGVLNWHHGTHTLNPNGSITLTPFGDGYQQIQDPCAAESNFIEGYNTTEMYMSWQIFMDPVDGPKLHLFQADGTPVAPLFQVYSTANMLPNQLLRNVTVTVTDQSAALFVSNSARRWTPSGVALIVSGAFTVGLAPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLA4</accession>
    <name>A0A4Q9PLA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_826879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11153" checksum="A732FFEA37B16A84" modified="2019-07-31" version="1">MTPYFPLARSILPHRRQGCGLRFLIHWEGFPYSHDSWLPGSMCRVLAALILAYIPIMNSVTLSLTCLDVCICFRVEEGVRTAPYSESSLPTYKTLYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLE4</accession>
    <name>A0A4Q9PLE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_934684</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLE4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLE4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU54935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="295" mass="33221" checksum="7B66E04807EBF234" modified="2019-07-31" version="1">MKYCSRDCQKASWPTHKPMCRSQDANPMRSAITPAEVGHSTGISLARAVNRWSKMHDYTCDIIAHVEMMLDGNWSLPASGERVLLFGLVSRTPSDPDGSPSAEFTVDVHYIATRREYVTHGIYIVASQWEPNAVRSRQELEASLRAKLESVEGTPKLAGILPKTTYLVGTGMVTGGSCRVYFPTGYQPGAPVDLVTKVWLKLLLNICLETINMGLVLRPRDLRDRSSTLPLIGKYVQHKKKWRWQSAEEWAWKALAKVMLEKYLCVYTPSDIFATYHKLWQYGMPGNPAPAEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMY6</accession>
    <name>A0A4Q9PMY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_933225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMY6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7618" checksum="49408A717D241745" modified="2019-07-31" version="1" fragment="single">MLNLTPLRVLAGFQAVLLWVGIHLHHGKSLAAFLKAIGFTLSLMDGRDVASGQLERTVRGRYRRARSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN44</accession>
    <name>A0A4Q9PN44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_950712</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN44"/>
    <dbReference type="STRING" id="114155.A0A4Q9PN44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028202">
        <property type="entry name" value="Reductase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14759">
        <property type="entry name" value="Reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="10">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU55604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="551" mass="58317" checksum="26BB861B54CF14B5" modified="2019-07-31" version="1">MSHKTIAVLDASELKDGEMKQVGFEGDGKVLLSRLGDKIHATSAFCTHYGAPLAKGVLTADGPCFNVCTGDIEDAPAPSALHSFKAEVKDGKIHVTADPSLTTSANKSRPPKLLATGSDVPVGQTKGVVIVGGGSGAFMAIESLREHGYKGPITVLSKEHHSPIDRTKLSKALISDASKLELRSTAELRAKYGVNLRQGVEVTGVELGNKEVVIGATQEKVPYDTLVLATGGIPRRLPIPGKDLSNVYTLRGVEDAQKIDAAAQEGKRLVVIGSSFISMEVVVAVSSRKLVSIDVIGQEEFPFEAVLGKQVGAGLKKFHESKGVKFHMQSKVEKIIPSDSDSSRAGAIVVQGSDGKSTTLQADVVIMGVGVAPATEYLKNSKGFEQVLERGGGVFVDEFLQVKGVPDVYAIGDIALYPQHGTGETRRIEHWNVAGNHGRAAGKTIAEGKGQPFVKVPVFWSAQGQQLRYCGVGAGFDDVVIDGNPDELKFVAYYTKGETVIAVASMQKDPVVSKASELIRLGLMPSKSEIKSGKDLLSIDISSVKAKPKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNT3</accession>
    <name>A0A4Q9PNT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_651796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNT3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="126"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="430"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU55886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="879" mass="94161" checksum="D1387873CFB6890D" modified="2019-07-31" version="1">MNAAFSQAPSMATIQPSRPDLTLSIAPVAFPESLLKELSASVRGPVLRPTDSEYTERAKTFNGKLKPTCRVLVSPLDAHDVSAVVQFCRKHDISPSVRAGGYGIAGWAVAGDLIIDMSMIRDIDIEPPVPAGEDDGSSKDWTPIGSKGKGRAPLLQAASTSAEDGRLIVDGTQTNASTASRKRRRDDRSPSPGVDEIGSKTGHGQFDGASHAVASFLRGPPLPPIPGDTPRGPPVNRQRLHSPVPPSQQDAEHPMSEAPHVSEPDRPRGRSLLQPVPPPLTEDTRQKSGDSTTSTDSVSHFSASTGVSHSSDATSLPSPVDGDSSVNSTDDASGRVAIRSTNATDVFDYLSSNRAPPMFGHTVGVDGVSTGVSAMGPFSMSRFVMPPNPGSGGVAAFNPMLGFSMSLPASTQYSLQSGMPMVSSGQSMPAFGSASSSMPTPVAMPGGPFASTPGTLGLSHAHAQAGQDGESGNNVQEHARHLGNTYHSKPIFPHTYVTFGAGMRQKEVDLYTADHPFEGMNPVTNEREEGVVPYHVPMSAHPVGSSIMLLGGFGFISRMYGLSVDNLVEVEMVLADGRIVIVNAESDPDLWWAIRGAGSAFGIATRYKVRAFPVPVVFAGNLIYRFRRATAPSLIKHFRDCIKGCPRELYANVLLTAGPANKDSLVVIQMCYVGPKAKGMEYLQAISSWDGERCLLNEVNEKSFLNQQDSVAQVLRGQAGRQWFLRSTLVSTLSDEVINQTVLAFAGTPVGCTWIFELAGGAIGDFEDTCLPKEQREATWTVAALHQWDMGIDDPRCITTAEDWMKTTISPVSTGGPLPTFLGRHETLARTKQCFGKNWDRLVELKKKYDPDCFFKNSFWPLDKGGQPIEPLTNEPPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNX6</accession>
    <name>A0A4Q9PNX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_960508</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU56019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNX6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="549"/>
            <end position="550"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="617" mass="66841" checksum="22BF61BAF53685DD" modified="2019-07-31" version="1">MGSAASHPAAGNERFFAVPGPLPPGEPKPWPRHDYIIVGGGTAGCVLASRLSEDPNTTVLLIEAGKNFQGDVPTKIPFTFANLFRTERDWDSYTVPQRYLDNRETYWPRGKILGGTSATNASIYHRCCPEDFNEWVSLGAEGWSYADLNPYFLKAEKFHQSSKHPGVNPANHGAYGPWQTSYPSETAPINGYVIEACRELGMRNIEDINAGRGHLGVTQLLGTIDSNGRKSSTATAYLSDEVLKRPNLTVGTEVMIERLVFSDVTPPGQPPKVIGVEMRTSRNAQLYCTGVNREVILCAGAVATPQLLMVSGVGPAQELQRLNIPVVQDLPSVGRNVIDHVSSGPIPFRVKSGSLTYDFLRGTVSSTFEMLKWRFFGTGPYASLDYSSTAFVRSTDNALPYYANSITGAPVNDHSSGPGAPDLEIRWVPQAVFGDGFPKPTTGTEGVTFAAVALKPESRGRIMIKSNSVWDAPIIDPNYLSTESDMNVLVRGIRLLLRLAHTDPVASKLHLKGNSINTSSPWWPGVGDPNLITDREIKEMLRRTALPAWHPVSSARMGQSPQDSVVDPSLRVHGIVGLRCVDASVFPTQVSGHPCAVVVAVAERAADLIKASAASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP41</accession>
    <name>A0A4Q9PP41_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_932390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU56006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP41"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="5"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="278" mass="31169" checksum="A6AFA24517A601E6" modified="2019-07-31" version="1">MRLSALLIYEFSITFARECNAIWGSRPGFFTLLFFVNRYGTILNAVALFVLFFPMENQVFSRLQGVLMILPYLSWIVFSAFRAYALADRTLLIGFMVLILSSGFVGLTIWQLVLTSVQDLPSPFDCSASIVNTKQLSIGGTFMIAEIMVIVFTLKRTLKLTTRRNRGPRTLMSIVLQNSLFYSSLLIPFLFNALVLVNSFTVTQENQDQLIFRALLIAGNFRDPITSILISRFLLNLGELSHSDMSTGDSLGNIISSDITMHPSDVISLHLPLDRPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPS7</accession>
    <name>A0A4Q9PPS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_950186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPS7"/>
    <dbReference type="OMA" id="FCTHIER"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16548" checksum="5189C4C058491C93" modified="2019-07-31" version="1">MSGAATASMDSKATDKKAKKFFLPQPAVDLREALYANGRQPSDSEKRAVYEMIVKMEGCESYARKTHSNFCTHIERKRKTGFRDYVVAWLQQVPNPSLADVLLWSRVLQVSPSVVFEIIMAEVPRGVTEFVEHQHALSLCNTMNPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ39</accession>
    <name>A0A4Q9PQ39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA processing factor 3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1023891</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ39"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ39"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
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</entry>
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                <person name="Riley R."/>
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                <person name="Grigoriev I.V."/>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
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        </source>
    </evidence>
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                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
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        </source>
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    </evidence>
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        </source>
    </evidence>
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</entry>
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    <name>A0A4Q9PTV8_9APHY</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57794.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6668" checksum="6A60681EB89385E3" modified="2019-07-31" version="1" fragment="single">VVLCSVHVYHVVTTLGTMMLSSLWAHATSCHIWNVSLQVKPWLGPGQGVGAQLAGSRLSLLR</sequence>
</entry>
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    <name>A0A4Q9PUM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16572" checksum="5FAE636332DCC6E6" modified="2019-07-31" version="1">MGMAPGTKGWRFCDPKSRRVGKSRNIIFAVPKRMQQDSNDDYELIKLSSPPPLEGESGSSGELASGGDSAPEVAQQPPADAPVTAKLPTSPPVKPAPKAVPQTAERRALCNLPHLDYKAAEEGKGKVIKPPVRDPSADSTADDDEVEQLVGDQETT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUU2</accession>
    <name>A0A4Q9PUU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_948709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUU2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUU2"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="517" mass="58709" checksum="2890EFB171EEA221" modified="2019-07-31" version="1">MTKTDWDILIASTCLKLLLFPAYRSTDFEVHRNWLAITHSLPISKWYYDTTSEWTLDYPPFFAYFEKLLSIPAYFVDPRIVDLNNLNYDSWSVIAYQRTTVIVTELVLGAAVLKFIRGAENPAMQRIISASLFLHPGFLIVDHIHFQYNGFMFGILLWSILMARNDRKLASGFLFAVLLNFKHIYLYLAPAYFIYLLRSYCLSPSYTLLPGRFLSLANVVILTFLASLGPFLLMGQLPQLLSRLFPFTRGLNHAYWAPNVWALVTALDRVLLKVVSRGQLAGIAVNEFGVASTSRGLVGDTVFAVLPTVKPIHTFAITVAFQTIYMGKLWMNTSYKSFVTALTLCGFTSYMFGWHVHEKAILLVLVPLSLLAAEDNEYFRTFEIASVAGIFSLFPLLFTPAETLTKIIYSVLWVIFVLRPIHRQVYQFPRSFPFVVIDVLERLYLACFPLLQIFVTVFPLLTKRTTPVDGTSDHADAADTGVSALKFLPLMVTSVYCAIGLVWAFIRLSVIYLARQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVM6</accession>
    <name>A0A4Q9PVM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_819043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVM6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVM6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24746" checksum="8E14572A45D9EE9A" modified="2019-07-31" version="1">MIRKGLWGEYSRVHVELALPDIPVLPLFSDIPYSITVTTSTPPLSRAHASEHSSKPVFPPVPRKAQEIDFVLHCFLKLRARLSTGKANNDVMTILGDKKEETNQVAVESDIPDKNWVPLASVPADDKHEKEKEASEHGEEKGSWVQRATYQSTFRLNCPPSSVVANIECSYSLIVKVPFPGIGNSLKPEVPATITSGIADPLPQEQSNSNDDLDLLDLPPSVSVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWB6</accession>
    <name>A0A4Q9PWB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_818760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWB6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="298" mass="31548" checksum="CC58F6D39F2A4CA0" modified="2019-07-31" version="1">MRNPARDEDLPDLTAPENRALRPSDVSLVPPKPAQRIRTRADDPQNDIAPSQAHKGKGCATPSLLALVIATVQPSPRVADYLNAPQSGGNTPEAGLAPDIPQASVSSASAPVDTVSRPPAPTPTVPSSEQHPPNSHQGHPALPVAQSLLRPPQPAPEASASPDDAPDTQAANQAPPDPLDAGDSTRPADASQAPPTTAQPTATNKTRAPRKTPQWPPPADLRGAKWAYARNWYTKNNGSQADFEQHYQSMTPADRRVRVCRLSLFTLSDHTGTRVPAVWLQSDPCDLVSLHGLCSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWD4</accession>
    <name>A0A4Q9PWD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_818921</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWD4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWD4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008504">
        <property type="entry name" value="Emc6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20994:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12671" checksum="8A7F485C2BA3D0AF" modified="2019-07-31" version="1">MSATATTPEAAAQLLFQPNVQYNNARLYTVKFLSSCFSGAVAGVLGLENTLGFALFVFSTLLTSSCLYVKCKGKPAKFVPGGWWELVNPGQENMFSFVLVWTLFYGTHAPPTLFSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWS5</accession>
    <name>A0A4Q9PWS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_428394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWS5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWS5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25697" checksum="79B8418E25E668A8" modified="2019-07-31" version="1">MGRDDSSSRGRLDVDDRWRMNNSTDRYSYDRRDDQRRGGDSHDARDGEGWTGHGYNDVRYSPSAARRLGRPLHVFSILLRRMLWGGHQHAVEMTVQAATVAHRKTTVIQLVILATMTIGEMIGERRTPESTRGTAVGSLCGRPRGRRVGVMSLRGASLAMVSPPIGRIVLGSRLRRGILPAMKECLAPRPVSGATTQGAKRSQKIRAIRREAAITSSRRLSRISAVGATMIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWY2</accession>
    <name>A0A4Q9PWY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_976935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWY2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWY2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF243">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="465"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="391"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="612"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="721"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="425"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="624"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="872" mass="92620" checksum="3DD595D23A928468" modified="2019-07-31" version="1">MDRNNHTNNSGFFRHIYDPQLGHAIGNFVRGLMPQHPPHPSHTHPANQPPPEPSDARQSPDSLPLEPASRPETIEASSGPSPSTSSAFDTPTTTPSPASTSIHHSTHTTDMPPSDTHMPGAVQTQDGNHDVDMSSNWEQGPSQSSQSDPDPLARSTRRARAEDDDDEDQDDPRASNRQRRHAPAQDDDEHHFMPIPEDHGIPPSAPDAHASPPPDSTHQPPQQGSAPPPPPYSRMMWTFEFIPMHGRGPNHNAQAPEGGQSQDEPANGHFFINVPITGEGPAPQPGAAANQGSYSPIFLFSPYFYLPFTDGGNQPGNAGFAFPPFPFPFGMDLLEERDDPERAQRLVEGLEEVPVGLVRRMERAGGPGTDRGQVPTCAVCWESLLDPEGGGFEGNAELAKAEAEAAREDAASQQARESSMEVDDSPSAPVAGSSTASSSEPSKSEATSSPVSVPGELQHPKIVGLPCAHAFHATCLLPWFSKPGRTTCPSCRFDIDPDSLTYQARPLRARHGPQVARAAPGAQPEGVQGGPATQPHVFFGPLPPFFHSAAPPPPPPAPAPPAEAQNASNPPGGAPHTRASPQPGQEQSQNGPQRQSLPPFISFDISMFIPIIPGRAGGAPPPSGAQAASSVPPAGSQGSAPAAPPPPPPRTDNHGFPFDNTVLQEAVRTTFERMLSRGGFPIVPPPGTAAPGDNGQPRADRWFTFSTGPLPAGVPPMPPLNMNIPLPQGAPRRRSNSRRPVEKRQWAPPPAPGPTLRQVVERNERQLGLRCSDVSCGLGPSDDDPVSSVDVSSLRQIAIRPKSDTSGQETVCEHRFHPACLVSAERVAGWGQEVKTGEPAGEDEDVEVSCPVCRAHGVIPRIEWEEGACALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX52</accession>
    <name>A0A4Q9PX52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_925789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX52"/>
    <dbReference type="STRING" id="114155.A0A4Q9PX52"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18514" checksum="416A2017820B867A" modified="2019-07-31" version="1">MDLTNSSLHTLAVLTGGEGSSSCSLLAALLATHRSPTSSSLALSPRLRPPCSWSTMPGMLVLLSFLASLLLSCLCFPSVWALITGGDEFLDAHEAGLAVVASRTPFRESGPPACMAKLIMLRHKLQQDNTRRRSSTGQARRAARTFNVTSSRTPRNVPWGARLGRAYGKQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXE1</accession>
    <name>A0A4Q9PXE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_436863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXE1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="22639" checksum="9F29E97ED2850CD0" modified="2019-07-31" version="1">MSILPACSPPNPEITLSHARELSTTCGADISASPNHNLSIPQPTPADIPSQVNTPVLVTPAAAPIASSAQTSDAGPSGSTATESQAPGTIAPSTSSKKPRAPRKAPQWPPPADLRGDKWIYARNWFTKNAGTEAQFEAHYKSMTATERKVSCSYLSRSCTHRNTLDRRPRASWHVSSTHSAATGRAVRTSAPCHSRRVSPASSFHLCQAGNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY61</accession>
    <name>A0A4Q9PY61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_924434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY61"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="8"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="573"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="730"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="421"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="645"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="733"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="757"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="782"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU59693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="812" mass="89211" checksum="56FE0612417A93B4" modified="2019-07-31" version="1">MASPLDLYEPLDVVGNGSFGIIRKVRRKADGLIFARKELNFERMTERDRKQIVAEVNILKDLHHEHIVRYHDRHVDRDAGILYILMEFCGGGDLSTVIKQAQRHNRLIPEDTIWNYFMQILLALNYCHHPNSGHGRTSSVGTPDSDGKEKRAQILHRDLKPDNVFLDEGNLVKLGDFGLSKALPQASFAQTYVGTPYYMSPELMQEKAYDSKSDIWSLGCLVYELCALKPPFHEAKTHAELSILIRNGRIPPLPKGYSPALTAVIKSMLNLNPAMRPSASQLLQHERIDLAYKVFETQKMLNTVKSHKSSLLAKERDLVARETTLAEREAKLAAVVAQKDEELASLRTVLATAESTLQQRVRQAVARRDEELRAMVLKQEQEVAERMTRREQEIMEAVRRREEEMARMWAEWERQTREGMGRAVEERMQWVQQRAEELERERLQLDGVRRELDAKMKALEAVPAVTGVGERRTRSKNPLEEVKNIMAPLSRLADSPEPIRAAPYKLPEFKTPMPTKSVNLDLEMAPPSAMKGVILTATGEPVATPTQAELAKLFVETPRVGLNFAKIFDFDAEESGESEGELDEDGYETDSRPRGSRREKDKDAEESDGESTPTQSTASSTSSTGNATLTAAPAVKPTRLRRPSIRAASASAAVRSASAAVEAGSSSSSSARNKVKRAASTSAVTSASASVAPAKTAAASVASLAQAPEPKYDFNDVENLPSPFLKKVEDRAAPAPTASKPATAARTGPRKSGTTLRAMAAMNAAKASSRAPSSSASMGNLAGNSASTAVRSSIAKAQRANEEARKALGTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYM0</accession>
    <name>A0A4Q9PYM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYM0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="644" mass="69246" checksum="35162CC3DC99CE2B" modified="2019-07-31" version="1">MVLLQLSWLHERYRMLFSGLDPVASSHGLPAVQLLLIPKHATPGNLLHVDTLLEQQDGVWGIYVSWDPRGANLDTNPSQVMCFQSASEYLSLITNIIQGKGKGIECSGVVNGAMLKHVGTSGNARDIVAVTDALDGLGSPLKVWGVSCTWMSYLTSAIAPEAFESALGTPFWLWNGREYVKLAGEQLREEMKLWEELPEWHRKILCRHDRFKGPRTLRTRRDPRIFTPAKKVKAASTPSSTVGRPVVECSGGAESVREGGGSLSRTCSDAAGSQNVEMVGEPSSPDSVVLRPSVDRPDGTAAAPARSGSSSDAMAGIVELRDVEMADDASSPPLVSVVCPSVELLGTVIVAGQAGYPCVIVTDTAELQDVEMADATPEAPSTPTPTPTPTPTPTPTPTPTPTPTPTRTSIATPTVLGVGFPPRATVARRAVSAPATSSSPSPNLIGQDLLKRLRAQLDAPQARRKAFSGPEKGEKMLNRPRPMLPLRFEKKRPTKGATPVKLTTPVKRELQCSAEDKENVSPATANGVDVTVKAPAGVVPRKPKGILKKPRRAERPPPAVIKRAKPGQQLQVQVQVPVKKSVRWAPEVIAKVSVLLLRSPRNAHLTRNVNKLAQTDLEMIVQAAKSPAPAQRLERLQQLVNTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYV2</accession>
    <name>A0A4Q9PYV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidohydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1038163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYV2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="3">
        <location>
            <begin position="133"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="633" mass="69459" checksum="F69455146CFF5CD1" modified="2019-07-31" version="1">MSASDKRPGQRATARTPRANTDSSNKQVIYTLFASAAAGTAAWYYSFIHTPPSFTVLPSSYALCADAGKIYTADPVKPNVDCIVVDKQTILTTGALLEVQFWWDGYQNELIAKWYGNEPSAKKPLPVINLRPGLIVTPGLADAHAHILQYGFKMQLRLDQARSLSELLDTLEDYVRKHPSGPDTWIEAMGWDHTKWSDTDGSFPTAADLASRPTLAALPIALHRVDVHALWISPRALELTKAHNGGGLPVSVPGGEILRDSAGEPTGIFVDAAQSLVPVPKWSRQQVREYADRAIKDALAVGLTSIHDAATSVEEFELFKQLDTERKLPIRVYAMADSDRLTLKEAKQLEIYDTSPTAHVRMRSVKLFTDGALGSWGAALLSPYSDKPDAHGIMRHPEEELLKTAREWWERGWGVNIHAIGDRANKAVLDIFEEIGNDPDDSDAIAKRRPRIEHSQIMRPEDLQRSGKLGVLTSVQPTHATSDMNYAEARLGPERIKGAYAYQTLLQASRNHVLPLGSDFPVESINPLYGFYAAVARLDNEGNSPHGSGGWYPAERLTRAQALKGMTLDAAYAAFAEEVLGSLSASKRADYVIFDRDIMDESRPVGDILEAKVEATIIDGKVVYGGISGNSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ92</accession>
    <name>A0A4Q9PZ92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_347385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="280" mass="29763" checksum="3EDEE5CB4E2E232D" modified="2019-07-31" version="1">MASLSVRSSAYRRLQYPSQHVEDVPDTPLDFAIAHESILLLTKLAAMDLGNAAPDRLPGSWAADPSRQDHPSPTRQAPLPTIAQPSADQALPITVVPMHCSGPYVIMHISHYLDLIGDRNPASRPASSAWHPEAHNPPMHASLNSTPAGGGSVGAASYTRNINPACSSCHRARKPCDRGRPCGRCVQRGEAEECSNRPRKRKREAATTHGGSESPANLTLAASAAPQETHDVGQANLLTSSSGQEIFPVQVAERTASTSATASSSLAHALEDIYGYPYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZB7</accession>
    <name>A0A4Q9PZB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_364658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZB7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="59891" checksum="1D5297B793B52C5C" modified="2019-07-31" version="1">MDRHNAFDNADVVYLILSCLAPDIDNCELWESESRARSRSLARCARVCSSLRLPALQVLWRRLEDMLPLLRLFSGLQIVEANDINGGVALYTLTSEILTHEWETFRVYAEYVQRVDSIFRPAGFAAKTRIDPSVWIQLGHLACGSPLFPNLLELGWVILSPQCTGLLFFLSTTLTRLGIVCFGIDEDAVPDNDDEWQAVLQALLPTTFQVASRITRLTMATGQIDYFSPHLSNLHSLRCFRGTKVDIRTLRALASLTEHEELCVHRFDTTDEPSVSFSGFPRLRVLIIAEHPSSNLVYDAFASPQLEELLIREYPGQYPLNITDSCKIWAHRFPSLQTLSFYISKEDHDGPPRWRPLRDAVAPLLALRNLRIAKLATWYTMFSIDDADMTAFAQAWPRLQSLQLCFTFGGYGPGSRPMPSPTPSSLLTLATRCPDLKEIRIRRLTVLRNSLPLLDEHSVPRHHGLQRLGVQHGNLEDAMVPEFARWLDHLFPRLVPKALNLDESWMRVLDAVKICQAERLQQQPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZH6</accession>
    <name>A0A4Q9PZH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZH6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZH6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="18352" checksum="1A1ED7754814AEB2" modified="2019-07-31" version="1">MGAKIGKNVSVFAGGHTGLMTEPDLVDLGDNVALDNCSVVAHINPRGNLALNACALRSGSRLLSGASMEPCSMLLEHTLLTSGEIAESDGVYAGWPAQYMDEKEYLRSKSRSMALSMFHTDPSHRALQRVQDNLEDERRRLDKKLTRRRIELKLLHTSTIRNSTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0L0</accession>
    <name>A0A4Q9Q0L0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_333598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0L0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="456" mass="48415" checksum="96668A90FDC2C084" modified="2019-07-31" version="1">MRNNVSNNLAMSGLPWIPEDVPCPQGVGQRTMAGLWGGAELIPWFGADEEEEDELAWLQGEAVAEEDEGEGGDGDGDGAEGNDDADGEGGVDGAVGSEESSEEEDGQDKTDETDEEDEEDEDEDEDENEDEDETDDVEEATAIASEAYFTVPGPRPGNSALTSAPLNGVVVRRSTRIQAQGVASSSTAPPPSQGPIPRPGRGQAASGRGEPAVVPTAALSAKARGKQPQTRARPAGKENQVGTAYNAGDSNGSEEYVVCPSASAGCGKRRREPEEDDDVDGDDDDDDDYTARAPSAKRKRLPGGSSVNVDAPKKSKRPRVPVDVLDRLCTVMPNAPCPWPTCTKKFQLVQTGKGEGGDAGAARPKCNVTEHFREHVEDGHIFNTNGAIVCPACGKTDKGNTFVRHVKAAHWHARWGCLLTLHGLECSWQGTRAGDVSQHVERTHRGHLDLLPPLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3T3</accession>
    <name>A0A4Q9Q3T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glycoside hydrolase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_946277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKN1/KRE6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3T3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02180">
        <property type="entry name" value="GH16_fungal_KRE6_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000140">
        <property type="entry name" value="Beta-glucan synthesis-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000135">
        <property type="entry name" value="Related to KRE6-glucan synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005629">
        <property type="entry name" value="Skn1/Kre6/Sbg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31361:SF1">
        <property type="entry name" value="BETA-GLUCAN SYNTHESIS-ASSOCIATED PROTEIN KRE6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03935">
        <property type="entry name" value="SKN1_KRE6_Sbg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="152"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="566" mass="62399" checksum="834C939CAF9D20D0" modified="2019-07-31" version="1">MTNGSRAYAPSRFSNAPSEASVGTTNEKTTTTTAPIATTATVQQYPYMWDTKDPDLDDALHNPDPVRDAALDRSCAPFSSRGWVNASALFLICGGIIVLFAAYPIIDHYVHQSPKIAGFNLGGVNGSGQVPQLTNFPNMIDSDTPQSARTRTGLDGKSYSLVFSDEFNQDGRTFYPGDDPFWEAVDLHYWPTVDLEWYDPSTITTQNGKLVITMTETPNHELDFMSGMLQSWNKLCFTTGYIEVSVSMPGSPQAPGLWPAAWTMGNLGRAGYGATTEGTWPYSYDSCDLGTFPNQTDKSGNPAVAATGGKGGTPLSFMPGQKLSACTCPNSDHPGPSVNVGRGVPEIDIFETQIDVSRFQAEVSQSYQTAPYNYQYEFVNTSDVTPIYDTSITKFNTYKGGVYQQAISAVTDINNANYNDQGYAVYGYEWWSNSKNRDEGFVTWVANGQKTWTMTADTIGPDSTTEISARIIPEEPMYIIFNLGMSPGFQAQDFKHLTFPVSMYIDYVRVYQRNDVIGEDSYSCDPQSHPTADYINSHLNAYSNPNLTTWDQAGYTYPRNSKYDGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3V3</accession>
    <name>A0A4Q9Q3V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_919372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3V3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="19942" checksum="FF210D575BDC4FD8" modified="2019-07-31" version="1">MCPRRRFSDISPSSSCSAPAPASCLLLPFLPSWPCHHRQCPFGRRMSRRISDRNSSATGTTIPRACHYLGRCVSWRALCANPYAAMIILNCTSPWSTEQGSAQSKPMLRPSHPQLPATEAHRSQGGCSRGLIGVYWFVANASLPACSDDRSRASYAFHHHGLYTSSGLCIPSRAVHQVSCTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q475</accession>
    <name>A0A4Q9Q475_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_919977</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q475"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q475"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="14">
        <location>
            <begin position="111"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="299"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="352"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="772"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="80"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU61841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1147" mass="129940" checksum="01413E8F5A1832EC" modified="2019-07-31" version="1">MAKRRAVAESDDESGSEHYSKRSRTADNSEVEEEVQQRATHRRSDKGKGKERARTAGSDLEEEDDGDDLGGVAEPDEDEEKKFEEEHEERIRERLMNKSKTQGGIAEMGIIESLEMTQFMCHKYLTFSLGPQINFIIGHNGSGKSAVLSALTVALGGKATSTGRGSGLKSFIREGQNVAEVSVQLKNQGEEAYKPKEYGKSIIITRRFTRDGSSSYKIKARDGKTVSSKREELQAICDHMNIQVDNPMNILTQDSARQFLSASSPADKYKFFLKGTQLSQLSEEYQTCMENISQTAKVLKRKAEVIPDLEEAYREAQARFEEAEMAREQRHKADELKKELAWAHVATKEAELTSKLTEVANIQHKVEKAEANVKQAEAHRAQVEAEVGRLEEELEALGTVDTLTARKDQLKAQIREGQTRLTQLRNDEKQMNESLAGVNNTIAELEKQIAEEQARLETRSRDKRDKTTAQLQKANAELAEKEAEHKNAVAEKTRLHGEAEGAEAEVKRLRQEQNQMRERIVECEEQIRRCGEMEKSKLAQFGHNMEWVLEQIRQSRWYGQPPVGPFGLYVKVKEPDRWGAVLRIVIGGLMGSFAITDPRDRNTLADILAKSNNSRTCQIIISEVDLFDFSEGEPPVQYLTILRALEVSNPYVLRQLVNTAHIENQLLAPSRREADQMLMGLPKGGVALAADLYRVVRFPEGGGQSTVLSGLKGNDPRHVLFRNSNADAEKQRWSASKQEYNSRLIDINRRIPELTATAQLARAEAKNFSAQEQECLRSIRELKNRISDLQKELNEDLPVNIQALQDALQEQLTEKESILSQFEHITRQKAKVNEDQAPLIAEADRLRVQIADFSDKHRALSDELANAVAARIHGNGVIDHYKAKAEAERQKLATAEKTAEDVQKEFESWTAKAAEYCERFPNPRKADVVQRTLEAVQAALKERERRQGASIEEIAEELQKKKAALDTAKRELKSLMSLNRALKKSVKSRLARWHEFRRHIALRCKVYFGYHLSNRGYFGKVLFDHVNGKLELRVQTDDQNLTQANTREKDPRSLSGGEKSFSTICLLLSLWESIGCPIRCLDEFDVFMDAVNRRISMRMMIDTANTSNRKQYILITPQDMNNIHVGNTVRVHRMTDPERGQGVLAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5A0</accession>
    <name>A0A4Q9Q5A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Molybdenum cofactor biosynthesis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_946216</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + AH2 + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + L-methionine + A + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the MoaC family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5A0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5A0"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21117">
        <property type="entry name" value="Twitch_MoaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="entry name" value="Molybdopterin cofactor biosynthesis C (MoaC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040064">
        <property type="entry name" value="MoaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="MoaA_twitch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047594">
        <property type="entry name" value="MoaC_bact/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050105">
        <property type="entry name" value="MoCo_biosynth_MoaA/MoaC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960:SF0">
        <property type="entry name" value="MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22960">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SYNTHESIS PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01383">
        <property type="entry name" value="cyclic_pyranopterin_phosphate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01386">
        <property type="entry name" value="main_SPASM_domain-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01067">
        <property type="entry name" value="SPASM/twitch_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="Molybdenum cofactor biosynthesis protein C, MoaC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="3"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU62181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="603" mass="66171" checksum="35DC28DEF1947316" modified="2019-07-31" version="1">MDAYNRQHNYLRISLTERCNLRCFYCMPSEGIELSLPEHLLSDDEVIRLATLFVKSGVSKIRLTGGEPTVRKGIVEIVGRLNELRKYGLQSIGMTSNGIALPRKLPALVQNGLTHLNISLDTLDPFKFEIMTRRMGHDAVLRSLRASLATPELQSVKLNVVVIKGLNDHEVLDFIEMTKDSRLSVRFIEFMPFTGNKWDKAKMVPSSELLSRIQARYPALRKGSDELNDTARSYVIPGYRGSFGFISSMSDHFCGSCNRLRLTADGQIKVCLFDAKEVSLRDEMRRGASDDVLLRTIGRAVSGKKEKHAGMEDIDVVTNRPMILIGDVHRPVSARSIQRSPRSRSEYTRNYSPRAHAARSLAVRRFSTAPTGHGGTPSARLTHIDDAGRASMVDVSPKEPTRRTATASGRIIIPRVAYELITDGTQEADHGHLANDAEMAALLKAKEKARSKGNVLVVAQLAAIMGCKRTSELIPLCHPLPISHVSVTLQPEAHHTNVGVHSRSASDAPTVAIDSFAVHTRSEIGLGEASQEPTYSIVCRATVSCEGKTGVEMEALTAVSVGLLTVWDMLKAVAGKEMVIGEILVERKTGGKSGDFERSSAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5L5</accession>
    <name>A0A4Q9Q5L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_871658</name>
        <name evidence="4" type="ORF">BD311DRAFT_761020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143435">
        <property type="protein sequence ID" value="TBU27212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5L5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5L5"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU27212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="296" mass="32482" checksum="3869DC4C518A6D29" modified="2019-07-31" version="1">MSSESTPTVVVTFIRHGESTDNLRDVWAGWKDAPLSNHGMNQAKALGKSLSSTRFAAIYASDLKRALWTGQAVRDAQPDPKPPLVESPLLREQRFGDAEGNPWSWNQTPGLSLEEHFARGIWPVLHERSQKFPGGESVDDLYVRATQAINELVMPRIWEAAREGKTGVHIALASHGLCISELIPALLVQDESGTHPGDKYRGLHNTAWTRLRIDVLGAKEGQPLDFPDSEPPKLRIRVTDVNRSEHLAGVTRQKGGIGSAAHDPAQKDIRAFFGGARLEEGRAASNAQDEAEVEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7F6</accession>
    <name>A0A4Q9Q7F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_918611</name>
        <name evidence="4" type="ORF">BD311DRAFT_755717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7F6"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="176"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU29791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="359" mass="39530" checksum="5FC3DEAACCAF7F4F" modified="2019-07-31" version="1">MPALTTVPAFPSDVPTHSLIVIDYQLLQAGSNDEMAKLWHAATHLGFWYLSNHGVDREVNAMFDVGAETLALPLAEKMKFEQGDTGDSFGYKARGTIATDLSGTRDTVEFLNIAQDDAVSWPRPIHRTYPSTVNARMQDAVIPFVRKSMAVNNTILSILERLLGLPRGSLANLHATHEPCGSEARVVKTPPNQSTAGIGAHTDFGTLTFLHNRLGGLQVMPPGSQEWLYVKPLPGHAICNIGDALSIFSGGILRSNLHRVMPPPGHQSRYERYSVAFFTRPNNNTILRPLTDKSRLIADAAAKNPREEFSSGATAGEWTARRIRKLRLRNRKGPETWYEAKGTEHQGLRHGPETVRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q863</accession>
    <name>A0A4Q9Q863_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8">5.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Pentose-5-phosphate 3-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">RPE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_915653</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8"/>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q863"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q863"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000191">
        <property type="entry name" value="ribulose-phosphate 3-epimerase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00030599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00057323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU63649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17031" checksum="9CBE41F372D2FA0C" modified="2019-07-31" version="1">MMVSQPEKWVDDIADAGGSLYCFHLEATSDPLPIIDHIHERKMKAGVAISPDTPSTAVTDEIAEAADMLLVMTVYPGRGGQKFLERCVPKVAELRARFPDKDIEVDGGVGPKTIDVCADAGSNVIVAGTAIFNAEEPEKVIALLKSTVDVAQAKIAAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8M0</accession>
    <name>A0A4Q9Q8M0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_808559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8M0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8M0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="37055" checksum="C9662ED44C0B8ABD" modified="2019-07-31" version="1">MAKRPRVPTALHAELTEYSSLLRALRTSDTLDLVSQLTQPPPLSVSQASFADDVSLTDEEDDDDEDGEAVNELPCTETASQDAFSAVASSPTSHGDHPRHVTTSDKLKGKERDTWTRWPLLAGDVHVPEWGLLDEVKHIAEHVLAITNPNEQAAEERDEEEVTVAHAIASSGTSAIPVAEHEDDPALLELGIDALTADCAAFLTRVLALLAAHVPAAEKSMQNRIAPIKWETVVDVACAHGVASPRIAELVRERMSRLYPPAHPNITHRTQHLRAMKQGLSHVLAKHQNDLLAVPSRVPVRVEEPANHKGSRRVMRQRNASTEAEPEAGPAPKRQRAVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q983</accession>
    <name>A0A4Q9Q983_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_915476</name>
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    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q983"/>
    <dbReference type="OMA" id="KPTWSVN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17378" checksum="82CFC7EE867E73FC" modified="2019-07-31" version="1">MISLSRHFISSLASRQFVTRSKSTLVEVDSVGIPLKPTWSVNELLSSYPRPAVSPSELKRLHELSALIPPADGTSEHTKLAQEMEELVKLVEAVKLVDVGEVVEEGAVPDGRIWASGQGVSLDAEAFAASEDADAVSGRALLAHASRTMEGLYVVETDKPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAQ7</accession>
    <name>A0A4Q9QAQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_915450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAQ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="56" mass="5870" checksum="B1D4FC5D30ABF083" modified="2019-07-31" version="1">MGLPAIACAGLRTLRWDSAARLPRGTVARRQAAARSLGKLDGGNLVGRRCSCLCTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB96</accession>
    <name>A0A4Q9QB96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <shortName evidence="13">SDH</shortName>
            <ecNumber evidence="4 13">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_838489</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4 13"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB96"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB96"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000217">
        <property type="entry name" value="Saccharopine dehydrogenase [NAD(+), L-lysine-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018250">
        <property type="entry name" value="Saccharopine_DH_Lys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 13 15" id="KW-0520">NAD</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="18">
        <location>
            <begin position="7"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="17">
        <location>
            <begin position="171"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="313"/>
            <end position="316"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR018250-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU64909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="369" mass="40893" checksum="345439FAA7A9A437" modified="2019-07-31" version="1">MARQSLWLRCEKKEFERRTAITPKVAKKLIDAGFEIFVERDDQRIFKDEEYEAVGCKLVENNSWPKAPKDIPIIGLKELPESDAPIPHTHIQFAHCYKQQSGWSKVLSRFYRGNGTLYDLEFLTDEQGRRVAAFGYHAGFAGAAAGALAFAAEKAGKPLGQLEPYENEQAMVDDVRRVLGGSAKGLKVIVIGALGRCGRGAVDLFRKIGVEEDDILKWDMAETAKGGPFQEILNADIFVNCIYLSSPIAPFLTEQQIAAAGKDRRLRVVVDVSCDTTNPHNPIPIYSINTTFAKPTVPVEVGAGNPPLAMVSIDHLPTLLPREASEQFSENLYPSLLELPNRQTARVWVEAEKLFRTKLAEAVKAEGLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBK8</accession>
    <name>A0A4Q9QBK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Survival protein sure-like phosphatase/nucleotidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_913928</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBK8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBK8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="347" mass="38242" checksum="D1AD9AEBE1AC5EFC" modified="2019-07-31" version="1">MTSSSATKPRVLLTNDDGPPGHESPYIYGLYRHLTQDLGWDVRVVIPSSQKSWIGKAYHIKDIITGRYYYPRDPDGEGEISETSRPLKDGEVGEWVLLDGTPATCANIGLHNLYHGDIDLLISGPNLGRNSSAAFALSSGTIGAALSSALSKIRSIAISYGTVHHPTPLNYYDPAHRLGARIIKHLWDNWDQDQGGLRQGEVDLYNINIPMIEGLLGDPGLPICWTRIWRNSYGRLFKAHKERDPAAKKTISAAGPDSPDEDPKGTRTGIVDQQTTPKDVGGLVFKFAPDMTDLISPSSVPVGTDGWAIRKGWVSVTPMRATFAEPIDWNVESEEEIEKTKVWKMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBS2</accession>
    <name>A0A4Q9QBS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_866806</name>
        <name evidence="10" type="ORF">BD311DRAFT_211330</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBS2"/>
    <dbReference type="OrthoDB" id="19448at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040684243" evidence="7">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="38"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="147"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU35293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="40111" checksum="2C8C78878100C25A" modified="2019-07-31" version="1">MQLFAVVSAALALFTAASAAPTQLKTIEKYAGEVKPSSYIVKLKDGVSKDAHLAWLAENHGASATVTHPEWQEGFLNGFAGTFGSDALSALRASPDVELISEDGVVSIFATQTNAPWGLQRISQAAKLADQNTSDLTFTYTYDDSAGSGVDIYIVDTGIYTAHSEFGGRATWGATFGGYADADGHGHGTHVSGTAAGATYGVAKKAKLFAVKVLSDSGSGYVSDIVSGLNWVGQQAAASGRPSIASLSLGGGTSQTLDDAVTALTTQGVHVTVAAGNSNTDASTSSPARAPAVITVGASTIADARASFSNYGSVVDIFGPGQNVISSWIGGVNATNNISGTSMATPHIAGLVATIIARDGNASPADISTKIQTLSTKGALSSIPSGTVNDLARNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDB1</accession>
    <name>A0A4Q9QDB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_953516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDB1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17669" checksum="79D3895F1CF0082A" modified="2019-07-31" version="1">MDTRRPSRDTAGASCPQARRTAPPAPSLFYPSNVTPAARSVSLCPPPKPQTARDRALETDPGHYRFRTRHHKGSMRYSTRIRHGTQPLLRAQTLMASGSESENPTFQPSLIRSRPCERIQRQFAQHVPALRVLCRRLGAVYAVSKGTEIDGRSHETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDB9</accession>
    <name>A0A4Q9QDB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_911822</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDB9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16606" checksum="54E7564AE922E7CB" modified="2019-07-31" version="1">MQQVRVRAAMLSRELPSRCLRLLCPTAPLVACYWQLAPSGVLKPSASEGHHYHFQFQVDNFMDVRCTLMFVLLMHLLPKSVYPYLAHPRCAVNQCAPTGLQKLPFLDGLSKQLQVQVCLSPSCISYAILLGEHRPLSPGVVTAGSCSVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDF8</accession>
    <name>A0A4Q9QDF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-sugar transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_803424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDF8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDF8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="525"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="570" mass="61989" checksum="C22910737D723E32" modified="2019-07-31" version="1">MSHSKDYTVLPQHVAHLHNHERDPEVGVYEKEQLDNPSDTQQNAAPTICGMPLKYVSLVTLAVQNALLTLIMHYSRVSTAPQHTYSAGSAVLMVELLKGFISLCVAFARLDSLNGASGSSLWNPRVQFYRFRRLGKEVFRPDCWKLSIPAILYVIQNNLQFVAVSNLEAATFQVSYQMKILTTAAFSVVLLRKKLSPTKWLALLFLAIGVGIVQIQNGSPSGHSASKNDMNAFKGFMAVVMACFTSGLAGVYFEMVLKNSQADLWVRNVQLSLFSLLPALVPIICSNSTPSGPAPGWLNQLFANFGVWAWATVLIQVLGGLLTALVIKYADNILKGFATSLSIVISFLASVALFDFQMTVTFILGSTVVLVATWMYNQPDAPAGDNFYPKECRSWNWRWRRTMQPASSALELAGGNIAISRRPSTSSLASVSPPPATGQSRSYPGSPVERDMPSPFFPAHLLEKNLLGKRKEDDPTPFFPVPLRASRAATRLAHYFTRTGSGSFIVPEGSGFAYPPSQAPSTMYASLPPSLSSTRPSSGVSSCTNSRPASAMGSVVSLSLGTLPEQDHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDQ7</accession>
    <name>A0A4Q9QDQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913587</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDQ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18154" checksum="2442BCD983CDBC44" modified="2019-07-31" version="1">MIDVAAFGRARHAGVTTIRLLASDALAVLAVLSRVGTTWLRCKVERAVGNAVRYVWCRCLSSLQCPTRVVPEDAFHMSPLHGIAVLGLLFRKGMVCSKARGIDRFCGIGEHISLLQSPICRSTWSRARVGTSLIGVTASCCATGRRASVLAAGFRSCDRVCEEVALHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDS3</accession>
    <name>A0A4Q9QDS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_912199</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metaxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDS3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDS3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03054">
        <property type="entry name" value="GST_N_Metaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033468">
        <property type="entry name" value="Metaxin_GST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050931">
        <property type="entry name" value="Mito_Protein_Transport_Metaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019564">
        <property type="entry name" value="Sam37/metaxin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289:SF41">
        <property type="entry name" value="FAILED AXON CONNECTIONS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12289">
        <property type="entry name" value="METAXIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17171">
        <property type="entry name" value="GST_C_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10568">
        <property type="entry name" value="Tom37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial outer membrane transport complex Sam37/metaxin N-terminal" evidence="10">
        <location>
            <begin position="33"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Metaxin glutathione S-transferase" evidence="11">
        <location>
            <begin position="216"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="45665" checksum="A99D34BD0F637541" modified="2019-07-31" version="1">MSDSKLSPLLGARNICLHIWPSHGDVVSFDVSSTAALLYLQLTVPGHFSVTHCANPDLSPSGQLPFLTHGLHHVSGLSAIIAYVRKLRNAHNLDGHLTSVQTAQLTARIAHLESSYGDLVNHMLYSLQENWSSVTAPALVSMLPVPQRYYVPSRVRKSHKPRLEAAGLWHVPEVEDEPEEPRRVLGRRKKQHAPNEAHKFKTAFERENVVEKARAVFDVYDRLLGDHQFFTGSETPTTLDVVFAAHTHLLLNLPFPDPLVSSVLTGSYPRLAAHHAAVLRIALPDPAHFPPVVQKSWSYSLRYLIPWPRAPPRRKSPSTVLANAPEVQKEEWRYRLWRWGFIGASVLIAAAYIQFAAITIVIQDGSARARLPLRGGPPPDDVEEAEAAEGEEEEEEGAEAEETEEEEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QG14</accession>
    <name>A0A4Q9QG14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ubiquitin thioesterase OTU</fullName>
            <ecNumber evidence="9">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_912195</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="9"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QG14"/>
    <dbReference type="STRING" id="114155.A0A4Q9QG14"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22745">
        <property type="entry name" value="OTU_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17059">
        <property type="entry name" value="Ubl_OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048857">
        <property type="entry name" value="OTU1_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057766">
        <property type="entry name" value="Znf-C2H2_OTU1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312">
        <property type="entry name" value="HIV-INDUCED PROTEIN-7-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13312:SF0">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21403">
        <property type="entry name" value="OTU1_UBXL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24560">
        <property type="entry name" value="zf-C2H2_OTU1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="OTU" evidence="11">
        <location>
            <begin position="147"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="358" mass="38273" checksum="CF4F748916C65F7B" modified="2019-07-31" version="1">MAPVRLRHPKGVTTIQVDFTNATVQDLQQEIFAATEIPPSQQDLKAGYPPHPLTIVPELPIDSLGLQQGEQLVVTQRPAAGHQAFQGSKGTAFPAPSPAAAMTGLTASQVRESPGPSRTGSAVSTSKAGSARGGGGPEYVLTSNGYLMHRVVPDDNSCLFSSIALIFEQDMSKAQSIRRIVADAIQKDPVKWNEAILGRPREEYIKTILKPSAWGGAIELSILAEHYATEIDSVDVETGRVDRFTPPPERDSGNRAIVIYSGIHYDATSLAPMLDAPEDFHQTITSGAKGEKGAESGGEEDEVLAAAKKLADALRAKRAYTNTATFELKCQICGKGLKGEKEARAHASETGHVEFGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4P7</accession>
    <name>A0A4V2K4P7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_195489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4P7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22084" checksum="EF1AA7D07DD326C8" modified="2019-07-31" version="1">MAIYRCGGRGRASRHQTAPERRTSGQSHAASQASHRVPARRARRRPRSQATSGGRKPPEGWRRLRDSLCHAGTESRGGGGGRPTDNGLGRVCQEGPGVGRARSEGAGSNAITHARTYQRPPAAPSPRRCHGSHSRIPAPHADEYSRPRPPIFAYAWAWVRGSSAPFGNAGVRAAIDSLPSPTAGNPFIHSGRADANEENIAKQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5Q4</accession>
    <name>A0A4V2K5Q4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rcd1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_921713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5Q4"/>
    <dbReference type="STRING" id="114155.A0A4V2K5Q4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000014">
        <property type="entry name" value="Cell differentiation protein RCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="37517" checksum="DC2689B6190AC4A4" modified="2019-07-31" version="1">MAGLISPKPVSYMQHNLQYNPYQRGVQAYSDTSANSIPPLSHPTPHQGVFLPGGNVSNPPLTVNEESKIYALVIDLLDSQTRESALLELSKKREQYDDLALVLWHSFGIMPALLQEIVSVYPLLSPPNLTAYVSNRVCNALALLQCVASHPETRQLFLNAHIPLFLYPFLNTTSKTRPFEYLRLTSLGVIGALVKQNDNTPVIHFLLSTEIIPLCLRIMETGSELSKTVAIFIVQKILLDETGLTYICHTYERFYAVGTVLSNMVNQLVETQAVRLLKHVVRCYLRLSDNLRAREALRACLPEPLRDNTFNALLKGDMVTKRCLTTLLNNLNEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6D2</accession>
    <name>A0A4V2K6D2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_982540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145313">
        <property type="protein sequence ID" value="TBU51513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6D2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="108" mass="12334" checksum="A96CAE34BAF76484" modified="2019-07-31" version="1">MPCRRALSKTKKAHIDAEFQEEWVTIAANRYTEEQQSGKKKLKGVRAICKEVEKECYEKTGTSIKLPKSTVSDRASGKPSIRDFNAEKRWLQADEEEEVIDFTINAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7V1</accession>
    <name>A0A4V2K7V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_928861</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="345" mass="38448" checksum="A566055A79F206D7" modified="2019-07-31" version="1">MTSIWNQYFPPKPEWSIDDVPDQSGRVFLVTGGNTGLGFATAKVLLARNAKVYITSRDRDKGRRAVDELRKISEAIRVLHLDLSDLYSVRRAADEFMSKEHRLHVLINNAGVMSPPIALLTRQKYDLQFGVNVLGHFYLTQLLLPVLLATAKATGQKVRVINYSALFGPDARIDYTTLMDGPVRRKCSPAQLYRQSKLANLLFALELAVQYGEQGIVSIAINPGNVHTSLLRHTGAVPVSIWDMFSHSVSKGILTPLFAATSPKVDQLNGKQLLIPWARLGQVPASILERCAQENLWDWLEAQTDCFQRMNHAKSDSTVFLEHGFDNVSVVSVRSKVAENEALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K954</accession>
    <name>A0A4V2K954_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_918727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K954"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17350" checksum="54449F46FF8AEBEB" modified="2019-07-31" version="1">MPTNRSSTQMDSATIPTSISPLSSDGHPGPPPRRVRITPEPAMQVLTTTRTCGRRGEAAGGNNECGWDSDDDEGGEHPVSLLGAAREVRCVRDDAEREQETSSTCAWKLQEIISTTGGFRTLWVSHSVPDSYGRSWYSSARGLLAGQLIPRVLHTLCRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Q8</accession>
    <name>A0A4V2K9Q8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_913435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9Q8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17781" checksum="D525B0433C4210A3" modified="2019-07-31" version="1">MFRFGLLASLSRPCGLLGHSLSLPFLIDNRSPSFAFISGGRRLWLIIFRAAFCSLLLVLVVLFLKDFLLFSDPGRSGFDHVALIVIVVIDAHIVPELPKKTRAVLQILFWLPSIDIGGVIRPLDQVSPFTVFYLRSLNDLDNKLRIFRVLAIRLRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWL7</accession>
    <name>A0A4V6MWL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_832775</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145262">
        <property type="protein sequence ID" value="TBU52203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V6MWL7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057525">
        <property type="entry name" value="UTP20_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011430">
        <property type="entry name" value="UTP20_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23099">
        <property type="entry name" value="UTP20_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07539">
        <property type="entry name" value="UTP20_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 N-terminal" evidence="2">
        <location>
            <begin position="257"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="3">
        <location>
            <begin position="1075"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20 C-terminal" evidence="4">
        <location>
            <begin position="1745"/>
            <end position="2009"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1823"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1834"/>
            <end position="1848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2012" mass="225089" checksum="2BF04007A5DA7279" modified="2019-07-31" version="1">MYSLLVSFSSRPDTTPLVLDPVYKLLKDSLLSHSRSLRLNALRILTSPLVQAPEGTAELLQKALQAEEISIDVQGVRERVLRIGRLPLMVKDGDDVAAEICARWLIAQLKVNLRPLWSLAASALSTLAGRFGDLVWVLLFEEVKGASWGSTGTVSKPAWMQDVAEESDNVWEEERSWRDPSAHKLRMAIAKWSCHRAAQHSIVQRQAIGDRLDATTYETQLLAVLEECSSLAEKHNRDLIPHFLSLAGPDAPSKLPRYKLSAWLKLFSKFNNPNAFRSTETMRALYISHLSHPDRGLQRLALSCLLTFKSPRLLPHEESLRLLLDDTRWRDELTQLDFAQLEADERPELVGVIIRLLYGMMLEKRGRTRGADRRAAVLSSLAGCSDEELTLLVDLMLQPLRKEQSMEVESGPFVIRPVPEGVLEKQQVGFLTLLGDLLKHLGPRVVNRWQALLETVLHLIAGAQGALDAQKDGRVDDPMEDEVTEAEEEDREEPMGSLRTLRNIRQLGLKRLADFSRCPVVYDFSLYMPEAFRAAISPRLPSLDVENTQAPGALLDLFHAWAQRREYASYLVQYDDSVLPKVYDCLTATNVKPVVVSKVFDIVEQLQSHAVADDAILDTVFKPHVSHLLRNLSTLVSRSNGNVSAAIDVLGRRQITILSELAPYLSDSSQATMLLELFSPLLRKPHQVVPEKVKVDMITILCSLFPLIQDLSDASSAVYSKTYSLLSQLFQILRSRPSRIALIQSFYALARVQPTIEPLAQLMESLNAYSTKRLDEPDFDRRLTAFAQLNDSLCGTFSCGEWLPVIYNSLSFIQDPLELTIRSNAATALKRFIDSVADERGEYEETFLKVLYPGLKNGLHSKAELVRTEILGVISHAVARCDGIASLQEMRILLAGGDEEANFFNNIHHIQIHRRGRAIRRLVEHVNEGHLRSATLAEVFIPLVGNYIVPTDTLDHHLVNEAVNAVGQMARRLSWGAYHALVQRYMKRAKQKDAAERVYVRTIVAVLDSFHFPMEEVLSSDEAQTMESAAAEGEEALAEPKPLPEPVRDTTNLARIQDAVNTRLLPSLILYLEKRDETEDSLRIPVAVGIVQIAKHLSPESRDAQITKLLTVLSQALRSKSQETRDLVRDTLCRIACILGPGYLPLLIREMRAALLRGPHLHVLAYSVHTLLVHVTTGDHASAFETLDDCVIDVAAVSAEVIFGESGKDVQAEGFKTKMREVRGSSSKGVDSFALLAKYITPPKISSLLLPIRNILQETETLKVMQQVEELLRRIAGGLNSNAHLVPAELLVLCHTLISQNARFLKDVPKTELRGKGVKRTDHAIVQLKRRSAHDSDHYANNSFRFVVFGLELFNTAYRRGRFDFKDASMMSRLEPMVAVIGNTLYSSHMQVVGPGFKAAAAIVKCPLKSVDKALPVFIRQIIDVIRQAGSTEPEAIQTAFKSLATILRDHPGAQVKEKDLVYLLELLTPDLEEPSRQAAVFTMLRAIVARRFVVPEIYDIMDKVADIMVTSQSPSVQELCRGALLQFLLDYPQGKGRLKNQLTFLVKNLTYVYESGRKSVMELLSAMVAKFETGLVQKYSDLLFVGLVMVVANDESAKCREMAAELIKALLTRLGTKQRNVIMSHVHSWSVQQAQPQLTRVSAQMYGLIVDFLKSDVASHMSAILEDMNSLLRRSAFALEAASSPREVSDHHGNDVLAQGWQTPYHTLLVFSKALREEPGLATEDGGVDWSSVVTLLLFPHAWVRTAACRLLGSLFAAVPVSAPKSGESLFSRAGMEEIAAKLSLQLKSENLDEQLSLQIVKNLFYVGKCFCALEPQPSGMEVPVDDMHDTSEGDQTEELEDMDDDSLQNGEHHPLSRLFSRLSYQARASLIRRRSKARSAANWSQQPAAVLKWFAAMVSYMDGDVVEQFLVHILNPVYRIVEDDTVRDPQMEELKTLAVELQDLVQTKVGTSRFSNVYNGIRQQVLSVRRDRKAARVIQSTTDPVVAAKRRLQRNAAKKQSRKRKNEEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWL9</accession>
    <name>A0A4V6MWL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GRAM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_962633</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145252">
        <property type="protein sequence ID" value="TBU52403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWL9"/>
    <dbReference type="STRING" id="114155.A0A4V6MWL9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="8">
        <location>
            <begin position="257"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU52403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="627" mass="69698" checksum="A4D5965DC968C0DA" modified="2019-07-31" version="1">MSIPPISPAPAETSSAAARGRTSYEGVSASTSGGGPLTPRSARSRQASLNVAPSDYSDRDSFRSHASDSDPSDESDELDLDPEDIPVTGFAVASNKRNQDFHELFPTVPEGDYLIEDYGCALQREILIQGRLYISENHLCFHANIFGWITDLTIPMYEVISLEKRMTAFVIPNAIQLSTRTAKYTFTSFLSRDTTFDVLFNVWRLARPEDSSDMGIGSQRVSLDEGEDGAVVVTADGAASRAAKVTRCDCAKTGQQHYTETAMDAVFPGTPDKIYNLMFTSGFMKDFMRENQKLLDIQISDWTPTENPQLLARNMTYIKPLNASIGPKQTRCELRDETIAINFDSFVTMLTTTRTPEVPSGNVFSVKTKTCITWASDVASRVLVTTQVEWTGRSFIKGIIERSCIDGQKTYHVDLEKAMRDYIHEHRAEFVPEGVDVAAVEESVAAVVALEAPPGTPTRAQSDEEVRKERERERNRRGLQWAYDTFEGALKVARQSTEGALELVSDAWDQSSSTTILYFVIVFLVLSNLWTLSVMGGREEVGRRKETRKMEEREKWVQGIVTALWEELLANRGQLGGIAAGAVPPLAPRPPHGDLREEVGALATQLDLIEQRISDIRENLKQLDQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M7U1</accession>
    <name>A0A4Q9M7U1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD310DRAFT_261853</name>
        <name evidence="22" type="ORF">BD311DRAFT_771325</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 464.89</strain>
            <strain evidence="22">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="ML143567">
        <property type="protein sequence ID" value="TBU21922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145267">
        <property type="protein sequence ID" value="TBU52088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M7U1"/>
    <dbReference type="STRING" id="114155.A0A4Q9M7U1"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="21">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="18">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TBU21922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TBU52088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="169" mass="19208" checksum="4C399BF585ADBEF0" modified="2019-07-31" version="1">MSTNCRRRLIRDFKRLSTDPPGGISGSPCPDNIMLWNAVIFGPADTPFEDGTFKLLLTFDESYPNKPPTVKFLSRMFHPNVYANGELCLDILQNRWSPTYDVAAILTSIQSLLHDPNPNSPANAEAAQLYRENMKEYVRRVRATVEESWLDPEEHAAMEQDSSEMAQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M8L9</accession>
    <name>A0A4Q9M8L9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_990926</name>
        <name evidence="5" type="ORF">BD311DRAFT_810833</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143508">
        <property type="protein sequence ID" value="TBU23329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145204">
        <property type="protein sequence ID" value="TBU53818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M8L9"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990837">
        <property type="term" value="F:sequence-specific double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052631">
        <property type="entry name" value="Paired_homeobox_Bicoid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255:SF3">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46255">
        <property type="entry name" value="SHORT STATURE HOMEOBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 2" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="4">
        <location>
            <begin position="127"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="1">
        <location>
            <begin position="129"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU23329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="525" mass="55945" checksum="0014BF024A80D980" modified="2019-07-31" version="1">MSRNAADAPSSAPSNPTDEQRRRRSPPRPFSNSPSPHTLPMDPRNIPEASLTSNIPSQPVPAASFTRVHAPSAAAPSSNPESSHRRRKRERSSPSGSSSQGDMADTEMEGGTSKPSTSESAPEGPPPKKKRTRTLTTPHQAAVLHALLAQSRFPTTQMREEVGRSIGLSARKVQNQRQKARRPRGQASTTSAPLTRPPQFGPFTNVPPGALSDVSPAAMTAHSGSSMEGFFPRGPGGASEMGYGSASASSSVLPEQFSHSHRDPYLAEDYARSAMPATQLAGPGIPGSSRRAQFDDPAWTGRSQGFPSRPSTAAVEIPESYRLTPRTGRPPGEQGPELTLTLPPVATNVPRVHGPASSPMTPLSAGPYPTLASLSSLESNSSTHRPRSFDDPRRTLPPANVDFASFRPVLNIPPPFTLQPQPQWDDPAFSPYNRRRSPPSQLRGAAPPFGDSPTTMRSPFVPEPLPSISTAIPMAYSGPSPGRSPSTTFPRTRFDPIRSIAGGAPPEHPARPGLYDYTDEPPPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MC08</accession>
    <name>A0A4Q9MC08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_915385</name>
        <name evidence="18" type="ORF">BD311DRAFT_768368</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
            <strain evidence="18">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the tubulin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143503">
        <property type="protein sequence ID" value="TBU23512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MC08"/>
    <dbReference type="STRING" id="114155.A0A4Q9MC08"/>
    <dbReference type="OMA" id="ESCYDIC"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000008">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 14" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="16">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="17">
        <location>
            <begin position="247"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU23512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU64112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="448" mass="49241" checksum="594E597D32FBD71A" modified="2019-07-31" version="1">MREVISLHVGQAGVQIGNACWELYTLEHGLNPDGRPAEDSKTSSDGGFSTFFSETGSGKYVPRSLYIDLEPGAIDDVKAGPYRSLFHPETMISGKEDAANNYARGHYTVGKELIDPVMDKIRRLADNCTGLQGFFVFHSFGGGTGSGFGALLMERLANDYGKKSKLEFCVYPAPQLSSSIVEPYNSVLTTHTTLEHSDCSFMVDNEAIFDICKNKLNVSQPSFTNLNRLIAQVVSSITASLRFDGSLNVDLNEFQTNLVPFPRIHFPVASFAPLLSADKAHHEQNSVSEMTFSCFEPGNQMVKCDPREGKYMACCLLYRGDVVPKDTSAAVASIKTKKTIQFVDWCLTGFKLGICNEPAACVPGGDLAKTTRSLCMLSNTTAISAAWSRLDYKFDLLYSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYQEVGTDSGDAEEEAGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MD05</accession>
    <name>A0A4Q9MD05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_924431</name>
        <name evidence="14" type="ORF">BD311DRAFT_670306</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143466">
        <property type="protein sequence ID" value="TBU25165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MD05"/>
    <dbReference type="STRING" id="114155.A0A4Q9MD05"/>
    <dbReference type="OMA" id="RYTRTYT"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF24">
        <property type="entry name" value="DOMON RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="128"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU25165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU59692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25400" checksum="87C544D08392B000" modified="2019-07-31" version="1">MALDIVIPLLPFEKYIIAHAILCVIGFLGLLPLGALVARYTRTFSPSWFTAHWIIQFALAGPVIIVGVSMGIHAVVLAESGPINDVHKQWGIAIFVLYLAQLAFGASIHYFKPKAWARGTGRRPFQNYFHAVTGLLLIAFAMYQVRTGFRTEWPLQTGRGPISNGANVFWYVWIVLLPVVYFAGVIFLIRRQFALERQARMGDTGSTEPNEPMAHQVEPSTATSTGKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9ML52</accession>
    <name>A0A4Q9ML52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_937426</name>
        <name evidence="7" type="ORF">BD311DRAFT_722532</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143422">
        <property type="protein sequence ID" value="TBU28350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145206">
        <property type="protein sequence ID" value="TBU53724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9ML52"/>
    <dbReference type="STRING" id="114155.A0A4Q9ML52"/>
    <dbReference type="OrthoDB" id="9989144at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF1">
        <property type="entry name" value="3-KETO-STEROID REDUCTASE ERG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0752">Steroid biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU28350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="49427" checksum="B7DC53B7BE845264" modified="2019-07-31" version="1">METPKGLVIVVTGSNSGVGFGICHRLLVQLSTGHPSDSKPYFDVSKPEHGAHEVAADEYAFSADAGVTIILACRSPARGQEAKTKLSRLLDEHISKLKRGSQEHEYASTFRRNVRLSVELLDLASIKSVLEFGQTVAKNYEYISHLILNAGTATYSHLDTLRFIVDLARYPMFGARNPRANLQVSGVMSQDNLGYVFQCNVFGHYVLYRSVQHLLIAYANVSKLSARVLWMGSLEAAPLFDPEDDWQLTNTLHSYQGSKYELELLSFELDKRALNPQHADVGTALGDLAGSHGEIRHLIVSPGVVQTNMSKTLNIKIPGYLFQARMLLGMLRFCGCTHIMSSLYAAAVGPVHVALAPLNSIPTPQNMPHVRPADTGYPPWHVYYGQTTSEAQMCRIGSESNRWGKERPGIVAVPVWEAYPNLSQTLLERFERLYQTFLQAYASNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MTI0</accession>
    <name>A0A4Q9MTI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Magnesium transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_918826</name>
        <name evidence="7" type="ORF">BD311DRAFT_719895</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MTI0"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU29882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="38157" checksum="187D045E99E10507" modified="2019-07-31" version="1">MVEDKYIGIIIAITGSVGIGSSFIFTKKGLIAASKNGSAATNEHTYFRSPLWWIGMVVMVLGEILNFVAYTFAPPILITPLGALSVIIGAILASFFLNERLGHLGRVGCALCLLGSLIIVLHAPPDRDVETVDEILHFALQPAFLMYSFLVLVYSLVMIYGVIPKYGHTNPIIYISVCSLVGSVSVMAIKGLGVAVKLTFSGNNQFTRPATYVFGVLVATCIVVQTNYFNKALDTFSTNVVNPMYYVGFSTATIVASIILFQGLNTDDPANSLSLLAGFITTFLGVHLLELSRTPSGGGDASELGYVRASGHAEEEVGLQTMYEPEPDDYEHVADEERAPLHRMSDERGRART</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBF2</accession>
    <name>A0A4Q9NBF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_914326</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBF2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NBF2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="54"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="252"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="36727" checksum="22575EB369BC0495" modified="2019-07-31" version="1">MASAYRLLPSALRASSPVSVTRGSGLVSSIAASFSPTSRLGKPRTLVTMASPPTIAVIAPGTMGAAVASRLTKAGCTVLTTLEGRSASSVERAKKAGMEDASLADIARRADFVLSIIPPSSAVVFAEAFKKAHDASSGNPKLAFADCNAVSPETVKRIAHVFDGSTVQFVDASIIGGPPTDGYDPAFYASAAPEDERTLDSFVGLSAWGLRTVALKGEGAGVGDASALKMSYAGITKGFIGLTTTMILAANASSPATAQALMHELHASQPFYLERITRSVPGMLPKAYRWVGEMEEISAFVRDGLGDGEAHVHRGFAHLYDRVEKALPDGEDVAVLKKFVEEAKATIRGSGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NC45</accession>
    <name>A0A4Q9NC45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_835096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145374">
        <property type="protein sequence ID" value="TBU51161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NC45"/>
    <dbReference type="STRING" id="114155.A0A4Q9NC45"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010629">
        <property type="term" value="P:negative regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000031">
        <property type="entry name" value="RNA exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="571" mass="62226" checksum="BA309AD043309DF8" modified="2019-07-31" version="1">MYAKSEIMKRREAVGIDDVRDLVLHLTADAPPPSWVRVENPRSINKVVALLIPGLTPDILSLPPLPTSATSNPNVPLQVPLPQTNLAGESSSGVPFINSTFTYACPTRAPGDQSRMHSVLNTFFQGPVTGEEKKRRLTERLISERTQEKSPMRYLLTLEQMIENGYPVPSYLAEVFEKPPGWVETKVSAADATLLSPPASDPPRIYAIDCEMCLTEDGKQLARVCLIDYASSIVVYDALVKPSKPVTDYLTRWSGITAEGLSSATASFDDVQSHILSVLSASPTPVLLGHSLESDLQALKICHPRCIDTALIYHHPRGRPLKPGLAWLTKKWCGREIQNRGEGGHDPEEDARACLDLLRKKVENGPGFGEFKVDTESIFERMSRSRTKGNAPITSAVVDHGNPAAWHGQKATTCIACKSDADVLAGLLSSLPSHHFLFGRLTALADVRGWITPKVTGDEPVPPPTSSTNAGRKEDGAALLETMATLDKQLRELYTALPARTAVVIFTGHADPRRMAELNARKAAFENALKAGKSVEELGKEARWTSADGRELEEEVEKAKRGLLFLGVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEJ4</accession>
    <name>A0A4Q9NEJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zf-DNL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_947908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEJ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NEJ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14475" checksum="EEF44E9FD468EE33" modified="2019-07-31" version="1">MLQNDPSAAASYPVGESSAPSTAGTSGAPASQPQTHITLEQPEPRLALTFTCTVEACGHRSTHQFTKRSYTRGIVIVQCPGCKNRHLIADHLGWFKESTEDGKLKTVEDLLRAKGEKVRRGRLDAGGVVEYAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFM4</accession>
    <name>A0A4Q9NFM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytolysin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_922130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFM4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20228">
        <property type="entry name" value="PFM_TDP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="320" mass="34710" checksum="A9FEAC60A76109D3" modified="2019-07-31" version="1">MASCTTLLGPPPSSSSTSSTVERTTVTNMSSPKTTWEDLSRLGWPINEVYKKANANRGGTMKGIGDLSLNSGIAAEYQWWSYNTTIGQPYILGRRPNSISREETAWSYDNTQNNRPFEQQWTESWTNSSSATLTVANSASITLSNHVTIFNVASSGFDISISTESSSSETKETSYSLSSTWTMDVGPGEKLSLIRVITTISETAEYGQDFGLESGSRVGTKGDRYNGHYYWGMSLNNLLNNPRGRLNLQGSSKNVTYSFKLVREGPKGRTSTPLPVDLYEASASQVAQAPVGVLANWTKTATEDVGSAPTEDMVPGIGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGG9</accession>
    <name>A0A4Q9NGG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_927151</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGG9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NGG9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="273" mass="30537" checksum="09C993E12509FBD2" modified="2019-07-31" version="1">MSSSTVSLYLDPQIRDWVLFPITVVMILVGILRHYVVLLLQSQPKKIPRHAIREQRALIRSQILRATSANSPLPPTYYKVISQHLSQAFADGTYLKDGPPKGDASSSTPPNPLTDPAAMDGMMAGMKTQMVMMVPQMVIMGWINFFFQGFVLIKLPFPLTLGFKSMLQRGVETPDMDVRWVSSLSWYFLNFFGLNGLYRLILGGENSADSSRDMATPFAAAAAATPGQAQDYNKLFKAERDNLEFSEGLHEWIANDVDTRILKKYGRLPAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NH74</accession>
    <name>A0A4Q9NH74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_936414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NH74"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.510">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043983202" evidence="3">
        <location>
            <begin position="24"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="525"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="416"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="569" mass="59571" checksum="AAB307C889087BE4" modified="2019-07-31" version="1">MDTLGRILSLFFFSSLFVSRCRALNVHTFNWGFPSSLVSASLGECETRSIDLIPLDASTSNTTGTPPYYMFAYAPQGTTIVSHLGDDPKSLSWQVQHPKGSKLFLTIVDGEGNTGGFANSFFDVVAGASTSCQPPAPKDPPVVHSNVTTAINTCDPWGLTVTGGVKPYSISLAAIRAPVVTNVTMGPNDDVLIYVDRADPGSQILAAVVDATGQWGVSSIAVNTAGAAVTNSSCPGLNTVSTTTAAIQSQEAAAKAAAAKAAKAKSTAIALGIVFGLVLPLILAGLAFWYWRRRQKLVERERPRPFDPSMQESGMGRPSLNVDTSVVRVNGQPQRTASWVVDINQDPGRQTDSPTSIDMASTEIRGSATPTPYLTSPQVQSAIASTVRSPQLQIPISALSRTMSPAHTPLSPPEPFATTPNSTSPAATLSPAQRYRKALEAQAEAQAARARLASGSRSVSPSPSGSSVVVAGPSSRVPQRSQSATVPRQFPTQPMPRRAGSSLRMPPVTALPDDSPDIIFQHSDGGIVEELPPPYPMDSRYSATPGPSTLSPARSVSPPRGSAGPSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJM9</accession>
    <name>A0A4Q9NJM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_815971</name>
        <name evidence="3" type="ORF">BD311DRAFT_664064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143425">
        <property type="protein sequence ID" value="TBU28080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJM9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJM9"/>
    <dbReference type="OrthoDB" id="3063206at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="162"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU28080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="314" mass="34795" checksum="E3A9E50E81C35921" modified="2019-07-31" version="1">MADAASFENPVILNLMSSYGPILIGAIFQCVLYGMAVLQLFLYFNNYERDSIWMKLYVRGFTMAIETASTISVLAAKSHSMAGYDSSLGISTPAVVDAVHRVWMTGLSTFLVHMFFIYRIYMGLQSVGGAGTRWFCLRNPDLATLSGRFLTNLGTSGRSIIAFVDIAIVAMMIYSLLREGYPRFQSSRRMIFRLIVLTINTGLWTAVFAIIDLGLIVPYPNQLYYCAVDFPLTSLYLNSLLANLNARDYIRSAAGDVEHNSYPMGDSTFRATTRGITSTNQSHGIHIQTSTDTTIYGDTVLGSKLPIIVYFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NK95</accession>
    <name>A0A4Q9NK95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_390571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NK95"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="281"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="623" mass="68028" checksum="D4FDD07CDA195F43" modified="2019-07-31" version="1">MLSALPAAQHVPFTLHSGPPYSYDLPSSLLSVTPRSSSLAMHGKSLSTFVSSSTPLSTSRPSVTSPGRMFRIFGFSPQEGSAGTSIVVNVHFSLLRSETTFLRIVVGNRALSTVVRPAQSEQENEWELEAIVPDLTPASTDASASSSTVPVTVQALNRSNVTLDSLTFGRFTYTRRAVPSPLLLCKQEVTDDFALGSLSAASTPDVRHAHSSPYPSPLLARKASRPTPASGTARARALNATMVAKDAQSARGQLKKQSLMRARRSSSDDDDVDNNFRAVLQLEMPTDPMSDIEEWDEEERRIGRRLVRFTRIQDGCTLHVTCEAIRPSDYTDGDTVVSCIYRPSEAVVPGELLASQCCITSVDIIFLLECLVGDIFNIEEKNRIRRNLEGFRPKTVSKNKVGSEEFFQKIMDFPAPKPRNIEKDVKVFDWAVLPQALEKIISKYTLYPAVKKEGGSTTPPIPESTSMPPHVPQASANSPYTASPTPDHTPSASPQQSYFYYQPIYHSPQYASTPLDALDSNNSYAAATALSCAGSYDAFLAHAQPHSGASSPMPMLSTSGARSPMPSDSASMAYPDSSQSLYQQHPYRGQSPYSSNNVYMTPFHVDHERMRMSSSPHGSQPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NN95</accession>
    <name>A0A4Q9NN95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA topoisomerase I</fullName>
            <ecNumber evidence="7">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA topoisomerase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_914483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 7">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="7"/>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NN95"/>
    <dbReference type="STRING" id="114155.A0A4Q9NN95"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00659">
        <property type="entry name" value="Topo_IB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03488">
        <property type="entry name" value="Topoisomer_IB_N_htopoI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.41:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.15.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048045">
        <property type="entry name" value="Topoisomer_I_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="772"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="6">
        <location>
            <position position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="903" mass="101958" checksum="B93EED3032ADD662" modified="2019-07-31" version="1">MSGDVSMLSDDDVPLGLKPSASNGTQNGHVIQNGNGHAVSESSMSEDDMPLSQTTRTKSEPVTPDTRLLKRKKAVVSESSSEDDKPLALTPAKGKSAAVRMPGAVAATTTKSTTANGKRTPRASKAIIESEDDEDDDDVPLAKPKRAANGKGKVAAKGKGKPPKKKVKQESESERDVESEDDIPAPPPKKAPAKGKRKVKVESDADESSSEDDKPLKKKRATATKKAKAEASDNVKPKKRGAKKEEDSDAVSKKSKAKKEEEEAETYRWWEEQNANRDGSVKWETMEHNGVYFPPPYEPLPKHVKMKYNGQPVDLPPEAEEVAGFYGAMLETEHAKDATFNKNFFDDFLKILKKYPPKNGLKITKFELCDFRPMFEHFEAEKEKKKSMTAAEKKAAKAAKDALEAPYTHCFLDGRKEKVGNFRVEPPGLFRGRGDHPKKGALKLRVRPEDITINIGKDAPVPKPNVPGEWKEVVHDNTVTWLANWVENVNGNYKYVFLAAGSSIKGQSDWTKFEKARELKKYVDKIRLDYNDALKSKNMAERQRATAMYFIDKLALRAGNEKGEEEADTVGCCSLRCEHVTLEPPNKLVFDFLGKDSIRYYNEVAVDDQVYKNIRIFKNDKNDDDELFDRVNTGALNRHLASYMKGLTAKVFRTFNASLTFQELLDRGTPEKGTVQEKLNAYNHANRMVAILCNHQRAVPKTHEQSMGKMREKLRGLKYERMKLRHALFAADAKFKKNKKYKDPESDLDDDAIASHEDNLKAKEIEKAEKKFQKDNEKAAADGKEPQDESVLKEKIKEIEAEYKKLKKERGTEKHALKKERPTEKIEDAIEKLEERIKTFKLQMEDREAGKEVALGTSKINYLDPRITVSWCKEHGVPVEKLFSKTLMTKFPWAMEVDTDWRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NP86</accession>
    <name>A0A4Q9NP86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_830613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145222">
        <property type="protein sequence ID" value="TBU53177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NP86"/>
    <dbReference type="STRING" id="114155.A0A4Q9NP86"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="3">
        <location>
            <begin position="211"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="323" mass="34255" checksum="3A24BD8A23CDF26B" modified="2019-07-31" version="1">MTSASGPTIAIVAPGSMGSAVARRLTSPPHPCTVLTSLDNRSPASISRARSAGMQDSPLTGIARRADWVLSIVPPASAESFAKEFIGAYQACEDANPRLVFVDCNALSPMTKQRVSSLFLGTSVRFLDARIIGIEPSPGYDPAFYAAASPKPGDQEALDAFERLGERGLNVKLLRGEGVGVGDAAALKMSYSGIAKGFIGLTATMILAAHASSPATAHALLTELRVSQPQYLDNIVRWVPGMFPKAYRFVAEMEEMAAFVRVGLGNGEAKILEGYARLFERIANARNGGTMAAEKEQASDVDVLRAFVEDAKEALKGAGEKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQ05</accession>
    <name>A0A4Q9NQ05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145266">
        <property type="protein sequence ID" value="TBU52097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQ05"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="18022" checksum="90FA600F5D7ED0AB" modified="2019-07-31" version="1">MLKDSVSSMLACTHTAHHVSAMLSVLRLTALCSLSKFVRLREGTKTGWSDHHRGAGCVALVQSRCPSCIHNQPYFIPVATSALCQRGGDSTSLSGNPTEDSHRTLVKKGKMYRSCQYAPRGRPRIAHLYEESVRSATYRLWYMSIREVSEEERPGSSPQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRG2</accession>
    <name>A0A4Q9NRG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_98055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRG2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="224"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU54256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="506" mass="59026" checksum="2855557216FEA87F" modified="2019-07-31" version="1">MFTYRLDQIPKKHFFQMGPKKKASHTQPHKPFEPPQPGPSSPSAKRHVNLQARSLYNTPNPFHSDRPLNDITGQPLVYPRTTVHPVTGLTVRDSPDYPTPEEFAKMHAIRTSKPPNRFGGPAGPNHKPQASSSGSPSSSASTTPGPATPPDTEPVPEPTGRVLVGKLVDQLKENGLEPEDEIMLARLRQIDIQGRLREDYHNMAEACERAEALHPIHQKMVRFKQAGEKRRAVARAERERIEREVAERHRREQEEYERRRKEAWRLQREQEEERLRQAELHRLRCEREMAERERRLREQREEEERKRLEEQWRREWPERARQAELRRQQEEIERKRKDEEIIRSLQAARQRFIEEREAARQQEATQRLIQQKAEQERLAREQFATQLKVGIANRYDELWGKIKANQVPDGSIRYTDFPFPVFANNVPAPAAITYEAVEEFVFSSLRRGAAGKSRKEILKVEMLRWHPDKFIGRGTVLSKVSLDHRESVKEAADAIVRHLTILMGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRG5</accession>
    <name>A0A4Q9NRG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_991883</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRG5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NRG5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="377" mass="41086" checksum="074766CBE857EFA9" modified="2019-07-31" version="1">MATTTYPRIAIIGRGPGGLTLALTLHRRGVPFTVYERETSADSRAHLGGMLDLGYESGQRALRENGLGEVFARNSRPEADSFRAYDPEGNLLFAKDPDPNQDPLDVRPEIDRSVLRKILVDAIPANAVKWSHALASVRDLGNGSRELTFANGNTAVVDILVGADGATTRASDTKKPELQDVVSMLGNGSMFSFGHEMMLGSQLNGNGRIRTYAWFPGPEDGKLPNEPAEARKVLLEIFKNRAPSLRKLIEYCNDGAIYQRSLYRLPLDHKWEHVPGVMILGDAAHLMSPAAGAGVNLAMLDALELGIVLADTINGARTVEEREAAVATWEKERIEAANHFAVIANTNVQAWTSTEDPASILQSMFKRMGDSAVRRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NST8</accession>
    <name>A0A4Q9NST8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Afadin and alpha-actinin-binding-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_1036834</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ADIP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NST8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NST8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035735">
        <property type="term" value="P:intraciliary transport involved in cilium assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052300">
        <property type="entry name" value="Adhesion_Centrosome_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021622">
        <property type="entry name" value="Afadin/alpha-actinin-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507">
        <property type="entry name" value="AFADIN- AND ALPHA-ACTININ-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46507:SF4">
        <property type="entry name" value="SSX FAMILY MEMBER 2 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11559">
        <property type="entry name" value="ADIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0130">Cell adhesion</keyword>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="7 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="469"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="727"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="409"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="603"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="631"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="750"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="883" mass="94336" checksum="D635D8304002B620" modified="2019-07-31" version="1">MNARTPKRLVHWALDASLSDLASPAFSDAGSSESCTSTSSLQYVNSQLIAHGFVHDTGLSLDGLAKADADRVVKCILGMLSQRIDDMTRTEDLTTKLRTLSYDHERLTSMYKTEKETAANAEREMNLHKSRASTASKSLLSSENAHKHTTAELQRTRTSLHALRIAHQTEIKKLEKEKERMLERWTKLSDSQLKAGMLPAGLTLMCANQGVVDANEVQLRGKGQGFLDVALEQAENARKELVEQNRRLRGVLLNAANELHSLLHAARTAGDADAPSEPEPLSSNALFQSQPAESAGDCLSSLFQSLRETISQKAASSTSSCNCLRRDSSSPSTQTQTQTTPARAQDGAEIERLQAVIDKLRADLDESQKQAAASAAQTQELFDRYAEDQRLAASSVGEMSVDLMTAPARDEEKQRLDARFKELEEERRKFTEAAVRLGKEKAALEAERLKLLEEKRSWEVEMMLAELPPTPAPVAGPSNPSIPAAPPSVVARRSPRKSPRKLKGKAASPRKTRVSRRSSGLGVLLSPKAKAPQKGKVVPAYETEVIPSTIPPSPVRPPPEFKTSMAVPAPPSPALLTSTFVLPPPSPAASFPSREEGGGTHLPPVPPLPRLEIPPLPEDTSEDDIMDTTHEPASSASSSSLPTASASSSTSTSSRAPAPFPSTPGARPFPMAKPLAQRMVHAYSPVKPSPLSRILMLARSPDSPPVAALDALAEVDENAMNLDVSHIPAHAMQPSRTLAEELGVSEDDDNPLREKPAPADKPKVVEKAKAKARGDAAPQVQAQTRTSRARAGGALEKENVKRAKLNPPSTSATTASGKGAAASKDVVKKPPSKPANGVSTRARTATGTAAGGRGTVVKPPSKGGPRRVPIGSAEAAPVPSWRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW75</accession>
    <name>A0A4Q9NW75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_923292</name>
        <name evidence="10" type="ORF">BD311DRAFT_760404</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143432">
        <property type="protein sequence ID" value="TBU27435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW75"/>
    <dbReference type="STRING" id="114155.A0A4Q9NW75"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13202:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU27435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU60336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9592" checksum="396C866BFE0719FB" modified="2019-07-31" version="1">MSDILQQYLEGKIDFEGQKLVEQISRNILIVATAVSFVAGFATQSLQVLFGVFAAFVVTLSLAVIPPWPAYRRHPVKWLSIKETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P042</accession>
    <name>A0A4Q9P042_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="6">SDH assembly factor 3</shortName>
            <shortName evidence="6">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_917637</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P042"/>
    <dbReference type="STRING" id="114155.A0A4Q9P042"/>
    <dbReference type="OMA" id="WQQTNEN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16600" checksum="BC3523A15C9D74DE" modified="2019-07-31" version="1">MFRASLVRLAKSVSTHPLNLREASAALLPPLPLYRRILRAHRNLPLEMRSLGDDYVKAEFRRHRETTNKVHIIGFLSQWKVYLDALPAGPEGGKAFRGKPLDPTTLEKMSAEQLGQLYEVMHVTKDVWKPVTPEQDGKTPSDNEGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2V0</accession>
    <name>A0A4Q9P2V0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_924499</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2V0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P2V0"/>
    <dbReference type="OMA" id="HYPDMFK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF885">
        <property type="entry name" value="2OG-FE(II) OXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="373" mass="41852" checksum="16806802FC64CB35" modified="2019-07-31" version="1">MTDSSSSNFSSIPILDWSLLSTTEGHAKFVEQLRHALINVGFLYLSHPPVAREDVEALVEYTPRLFDLPHEEKERILMANSPHFFGYSRLGAELTKGKTDQREQFDFGTPYENQWKPGDPEYLKLWGPLQWPPEELLPGFKATYLRYLDQVEQLSYDFIRLIAEAFEVPEEAFAPFLGGDAKPKPGVLQHRSKIVKYPARKEGDSDQGVGPHFDGGFLTFLLQVSDHPGLQVQNLAGEWIDAPPVPGTFVINLGKALETVTQGLARATSHRVLSPPPGSTPRYSIPFFQSIAQEICIGDLVLDFKPEILKLKDSRGQTGVVDSVNYQEYGQYPSGYVNLIGRVKSHPDVAERHYPDMFKQFFPQGLPAQGSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3C6</accession>
    <name>A0A4Q9P3C6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease</fullName>
            <ecNumber evidence="9">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_928068</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="9"/>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3C6"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3C6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07181">
        <property type="entry name" value="RNase_HII_eukaryota_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000016">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="224"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU57990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="36424" checksum="1F87EBB6C72D38C7" modified="2019-07-31" version="1">MKSDEVAESAGTIPSIPDPSLPLIDSYTYHSPTPTAPGPYFLGVDEAGRGPVLGPLVYGVAYCPLAYKEQLEQLGFTDSKTLTAQVRSSLLETLGSDPVNLGWSVRVLSPKDISAGMLKRPPTNLNQQSQNATVLLIREVLARGVQLSEVYVDALGRTTSYEAYLSSLFPDIAFTVQAKADLTFKIVGAASVAAKVTRDAWIDGWVYEERAPVPDPVASKFFRGPPTSSSAHRGEAAGARARARASEGKWAQETGSGYPSDPKTQAWIRSSLEPTFGYPSFARFSWATIKVALEKDGHAVEWIDDGQASLVQAFTSATGRDKDRCAVTKDLCLSSVSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4A5</accession>
    <name>A0A4Q9P4A5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_921697</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4A5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P4A5"/>
    <dbReference type="OMA" id="CRRMKEV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07629">
        <property type="entry name" value="BAR_Atg20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="379"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="554"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="585" mass="65764" checksum="08195CCD41E76DBE" modified="2019-07-31" version="1">MDAFEDENPFESEPERVQSDGSSSRENISGVSSPDINTQPGQISSPPTSPSKRNTFPSLGSHRQPQAYKSDFCCGRDHWLHSGEDVEILITDALKTSANSSSPYITYVIRAGSAEAHHRYSEFESLRNNLVKLYPTLIIPPIPSKQTIGDYAVKQAKAKEDAAMIARRKRMLQTFLNRVARHPILSNEHVFHRFLDGEVSWTEVLNSPPISLLPKNILKAPSHNPTDQSASPAYAALPNPSAAHPLRRPDQRFLDSEVFTNKFAAHLSGPMEKVTRRTMKRWSDYAQDHAELGATLNGFSLNETGQLSTAIEKTGQAVDATYMSTTKLLQEFEQNWAEPLHEYSQFASIIKKLLQYRHQKHVQYEMTQEALETKREQLEDLEKSEREARRLEEALSQGRPSTLRASYSHGEGELGEEGRPATDENEARREEESVYLPPHPGPNPVKRRAPGMGLLNALSYTLHGMMDVDPETARRNSITKTRESISQLEDALHLSAQDLKYSSSTIQADLDRFQRQKVADLREMAISMARSHRDWCKKNLEAWEEAKAEIDKIPDHPNRLPEEEGLGTNGAAGHGRRDSMATING</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5T3</accession>
    <name>A0A4Q9P5T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Spherulation-specific family 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_973167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5T3"/>
    <dbReference type="OMA" id="MYPLETA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021986">
        <property type="entry name" value="Spherulin4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35040:SF9">
        <property type="entry name" value="4-LIKE CELL SURFACE PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12138">
        <property type="entry name" value="Spherulin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="257" mass="27049" checksum="A1039E023BEA46F6" modified="2019-07-31" version="1">MQLARAASASALSSGVLIPLYIDPVGGPDCSGWASLLSTITAHPAVPYYAVINPNSGPGDANTQPGLEYQQCIPILKSASSSVTVLGYVHTSYADPSQTARVLQDVHTYAEWNSPYGVQGIFFDEVSGATADFATYQNYTGEAQKSFDFIALNPGAAPEDTDYYSLADILLTAEDFYADFSPNQLSLGPSTPASKQAIVLTDGPSTPPADLVSQLITTDKVGAFWVTDDTQANGANPYDTLPADIESFVADVEAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8X6</accession>
    <name>A0A4Q9P8X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_775137</name>
        <name evidence="6" type="ORF">BD311DRAFT_617234</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="2746660at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46481">
        <property type="entry name" value="ZINC FINGER BED DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Hermes dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU31222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8922" checksum="B39AD75EAF483BFA" modified="2019-07-31" version="1" fragment="single">IAMWVARRHRAFQIVEDPEFREIVRMLYQKAQLPSRVTVSRDVHDIHEMSKDNVLKLFKNLPGKIHIGVDGWTSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P996</accession>
    <name>A0A4Q9P996_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="1 2">
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25672" checksum="D522CE1695203FC9" modified="2019-07-31" version="1">MAVIVFSPEAVCTCTLYPFPPRLRRNSEGLHLSPRNVCDTLGAAQFRRRRRLRSGSHEPVFIRHASHATSYLNIVAGNRDAQRMACASFESRPCDATGSVALRALFYLPPCFELGLPCPFSPFANPPLSCSSALAGRSLLPRPNRQPLRCPRRPWGGEVLARSAHTKHALRHPAPILVHICPEWYYNLPLIKAIARRVWLQGLRDRLFGMQPYSAVRCQPSQAPVRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9C2</accession>
    <name>A0A4Q9P9C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prefoldin subunit 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_942530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="125" mass="14152" checksum="FE76BCF7F1206964" modified="2019-07-31" version="1">MALVLQERLQTTSADFQKIQNDLSLVVDARQKLEAQFSENELVKKEFASLTADNTVYKLIGPVLIKQDQMEAKQNVDTRLDFIRGEIKRVEGQLKDLGEKSETKKLQLVEIQAALQQHQQPTSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9H9</accession>
    <name>A0A4Q9P9H9_9APHY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40232" checksum="B4A72D91F4D3E446" modified="2019-07-31" version="1">MEGLARTELRKQEEALKEQEAVVLAQREQILSLQSQAGDAHTVSQSPLSDAFEVLRAPEDASSRHAEFVDVGSTIASYDDVVLSMVRTLNFEISEVASQVTNAFRVTDTPDHDNVNLAFERAREAVGPVMAELLESIQHQDDPIIVDIALKADMVGFAAEVASAWDFQHQSRSVFTGLYKQMRRSESQSVCGQWRSRARKYSKQCLYNSRDLVPGFSHQLAERIADLLTVAGGSSAAEDIHAAYAPHLETIIRTALDLQRITGEEVVACDYEVLTARFDEIFDSEQMEDIYNGEIAATGPPGTVPRVLSTADLGLRRSQKVADAVDDDDGVTTTMLLKPKVVLDTVVYELGLVDEEDASPSTAEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBN1</accession>
    <name>A0A4Q9PBN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_921224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU61331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28251:SF1">
        <property type="entry name" value="V-TYPE ATPASE ASSEMBLY FACTOR PKR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12856" checksum="B1FF0ED95788C5A7" modified="2019-07-31" version="1" fragment="single">MYSSMDGDISTPAAAAETSIAEDPLSEIFSGILAPGSSLNPSFLLVLDGALATLLLVLLGLFSITNYNPHLLFLSIVELCLWASIKWFVSVLREVRLQEAAHESPDGQPQKTVLKPKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCI2</accession>
    <name>A0A4Q9PCI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_940172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145249">
        <property type="protein sequence ID" value="TBU52469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCI2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCI2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="654"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="702"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="782"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="824"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="866"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="908"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="542"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="943" mass="102722" checksum="7B211A02B4C59B06" modified="2019-07-31" version="1">MPPPQQNPWNIYAEQLFPMGFGYPLWIPEPSRDRGRQVYIGDVGWIKQGEFRALFNCMKPEDDPVNEEKGVPLDFQLFNPKNVSIGRCERIGQKVVASSSIRTIEAQGDVGANAGGLPAVAGAGFSFKSTSDSGAFVMLAPPGIAEDIESKRHIVNHMRENFTRWLEFANASSSWGLDLNEQQMLFVCGTLKTTHWAVAAFQGNVFRSKEGYVSGDFGPTASAGFSVKISNEFLPANFYRTGPPRRDSWADLSRQASYPGYPSPSDAAIQGPSQCLFIHYYKMKRRFWLRQQPMQATAGPHQLPPGPDNSGLGAPMVGARGSSPYDFEPDGVQEETYDPVDHLLTYILENSEAAMAVASDLDLIALFMDRKFPEDVPEAIAQLGPSIEVDEYGVGTVSVNYTFLRKRRTREEEDAEDRLREEKRGRYLGDEVPHDNDHVPMEFAGPSQAYGRWDPAGSSAAPSYGGMGDPSMHSHGYQYPQGMQHPQGMPLPLGVEYQHSMPYQQDMYSQGMSPLVAVSMLDTPRSPQGAYPPGIPLSTPMGYLPADRIHPAQNPPLPPANSPLLSHGGMAPPPPPPPYPQNTNDDEEMGDGGSKAEGKRPDFNAPTSIHDGSVTALAYSADGKYIASGSEDTTIIIWDALANSVRHKVPIPPEIGHTDTISALAFSRDNIYLASASHDEGVIIWAVANGRLHLRIQPDHAIHSLVYTPDGRFLIGGASDGTLYLWNAQTYEEVRTLDKNTAVVTFVIFSPDGRLMATGGTESVCTIWETAKLEDGEPLNVLEGHRGMVCAAAFSPDNRRIITASDDGSSRIWNAETGEALVILHEHTGPVWTVAFSPDGKRIASGSSDSTVKICDSFTGDRQLSLDGHDSMINAVEFSPNGKFIASAASDNTVRLWNASDGSSHTTYNEHNDNVTSVMFSSDGSTLASGSHDGTVHIRRLLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDG8</accession>
    <name>A0A4Q9PDG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_835619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145456">
        <property type="protein sequence ID" value="TBU51001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5366" checksum="962606155D4EFF44" modified="2019-07-31" version="1" fragment="single">RSDPLGSDPGSSQGDINVGASGHMNRRVGRPSATRCSLLELGLAFSGHEPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDL9</accession>
    <name>A0A4Q9PDL9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_910854</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145382">
        <property type="protein sequence ID" value="TBU51142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDL9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15843" checksum="330C741789E819FA" modified="2019-07-31" version="1" fragment="single">MVSSINHTKDLADADEIVARIRQHASRIYDSEVAMTARAKKRRGPPPCFTCGKPGYARDCPNHDTKNAKDGRDAKDAKDAKGKGKGKGKDDRNSENKRKPKKDRPKALAAEEDDSDSDSDEYAYALIEHINSDLGEDSEEIALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDX1</accession>
    <name>A0A4Q9PDX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_952335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDX1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDX1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.30">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="231" mass="25038" checksum="5019B6CFCA331113" modified="2019-07-31" version="1">MVDHRRGGYPAVSSGISFGGGQQRVGNLAHTPYNAAILDAVKKSTTMCRIANFANSAYPYAGSTLHRFYNTTLVALCSLDPSLQRNFKGSAFACATWNLGPRAIAHVHTDHLNLAWGMCAITALGDCDPKLGGHLILWDLRLIIEFPPGTTILIPSAIIRHSNAPLASPDEHRYALVQYSAGGLFRWAECGHQTQKNFQQAGGAYAQTGRERWAGGVSMLGRWDELSASRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEK9</accession>
    <name>A0A4Q9PEK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_887983</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
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            <end position="177"/>
        </location>
    </feature>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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            <dbReference type="EMBL" id="TBU51591.1"/>
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        <source>
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        </source>
    </evidence>
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</entry>
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                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
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    </evidence>
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</entry>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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                <person name="Riley R."/>
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                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGX8</accession>
    <name>A0A4Q9PGX8_9APHY</name>
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        <submittedName>
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        <name evidence="3" type="ORF">BD311DRAFT_755923</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 464.89</strain>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="3192089at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU29628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU29632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="16802" checksum="F4BA830F5050FB0D" modified="2019-07-31" version="1">MAALTIETGVYFIQNAGTGTVLDLTLGSNANGTKVQGFTKHELNDVWVSAQLWIIAQVPGTDEYTIQNANSRTYLDLTGSNIQNGTPLIGFEPTGNPNQRWIIKRNSTNTAYVIGNGATGTYVDLLNGGSANGTAVNGWAGEGPATTNPHQLWHIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH52</accession>
    <name>A0A4Q9PH52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_203570</name>
        <name evidence="1" type="ORF">BD311DRAFT_764136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143457">
        <property type="protein sequence ID" value="TBU25664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145236">
        <property type="protein sequence ID" value="TBU52812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH52"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU25664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6354" checksum="CAF5031595D4EF2E" modified="2019-07-31" version="1">MSMAAVTRFRSGLAFSCSLSISRLGGLHLSPSEAGYQGSKHSLAFPACGVPVHRRTFLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH56</accession>
    <name>A0A4Q9PH56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UNC-50-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_941090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the unc-50 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145268">
        <property type="protein sequence ID" value="TBU52066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH56"/>
    <dbReference type="STRING" id="114155.A0A4Q9PH56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007881">
        <property type="entry name" value="UNC-50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12841:SF6">
        <property type="entry name" value="PROTEIN UNC-50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05216">
        <property type="entry name" value="UNC-50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="255" mass="28965" checksum="74E98B2E9D6D14F1" modified="2019-07-31" version="1">MDVLPVTSPNPGNGGQYRNSSPALVRVPVIFRRLHRFQQMDFEQAAWQLTYLCLAPKRVYRNVYFHKQTKNTWARDDPAILILIAACLCVSAIAWSVVYSYGIWGAIGLAILMVVRDYLLVGLVIATILWFFANRILLSPPSHSTLEDARVEWAYAFDVHTNAFFPFYLTLYLAQLFLVPIILKNNWVCLFVSNTLYLAGFAQYIYGVYLGLNTLPFLVRTELLLAPLLPLFTGYIVSLLGFNVAQHVLPLYFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHZ1</accession>
    <name>A0A4Q9PHZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937988</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHZ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12548" checksum="C1A188E2DDAA2B48" modified="2019-07-31" version="1">MPARDSDLIIEPSQYGDDRRSSIIMVELFSSGRGFATSSREGPLRTDPVNLPSKYAELRAEAQTRRHNEAQRDLMELPQSECKCSTGTTSPQYDTEDVMSESTPSDAPPAYSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ41</accession>
    <name>A0A4Q9PJ41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_104959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ41"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18207" checksum="73BB8DE6B90B0739" modified="2019-07-31" version="1">MHTNTSSSKVRTGTCASVDERDSCQACPPTRCLESVAAQRSQRGAGRLALGVAGAPALPTTLTDLPQLIPHKVRTRATLRDYGIPLHQAKRFLDANDALCSECNMATYEWHHGMACFECPHEKGSIHGQELGRWRYHGRISPKCCVKLRGRCVCIARLVSRLAGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJB3</accession>
    <name>A0A4Q9PJB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_100871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJB3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="187" mass="19729" checksum="116B6265CE7F4DB6" modified="2019-07-31" version="1">MFGQQAGGGALLPASMQFGFVVARLAYAAISISNAPHNASSARCSAPSAALFLPAVHTDHDLAHAANARHAPTSRPCHRNPSSSCTINRLPSSSPVPPAVDRVTPSRPPILTANCAQSLLTPLQAYVPKTEHEQRTSVPSSTCPHAQRRAVVDPSIEPRISTKGQTETGARPHGPPQAHHGTQRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJU0</accession>
    <name>A0A4Q9PJU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_951488</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJU0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJU0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="207" mass="23214" checksum="E09AF748CB561592" modified="2019-07-31" version="1">MHEVSRLLQAAAALSQLLRDAGVPHAFYGSVLTAVLSKAPLADEISCIVEGGAVHPFRRVRQACAGNEDFLIVASPWSNRLHVKYQRLIPPIDIEILPAGEEGPRRLDGATVMIVGRVPFLTITEFIRAKIKAWSIRGSERDAQEITFAMSRYWNRVDLNRIPEQEMNEFASRFPAVAPSWHELKRKYGMYVLAVPSTSFVRNAQLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK81</accession>
    <name>A0A4Q9PK81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_827806</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK81"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="468"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="620"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU54521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="784" mass="88507" checksum="ACC9CF2C2D79C7D4" modified="2019-07-31" version="1">MSAEVEEDHRPSPSSIASFSSFEGEKSIRAFSLNPSFDDSESLSSRHTEDPPDFFDPNYANDITWLEDDSPYPEVRSAVANYDDQSMPINTLRAWVLGILWAIIIPGVNEFYYFRYPSIMVTGIVAQLISFPLGRAWARWIPQWKVFGMALNPGMFTIKEHVLITIMAGVGAQSAYATEIIAVQRVWYKQNFNFGYQWMLVMSTQLIGFSVGGLARRLLVAPASMIWPNTLVLCALFNTLHSQSYAGIGRHDGLSRERFFAYAFVSAAVWYIVPGYLFQALSYHSGMGFSLLSFDWNQIAFIGSPLATPWWAEANVIVGFLVFYWFLAPLVYFTNVWCSQYMPISALGPYDNTGKRRPYNLTRILNADSTFDLQAYKDYSPLFLSATFAISYGLAFASITATIVHAILYFRKPIAVHLHRSLAEQPDIHARLMSKYPPVPQWWYAGILVVTFTFSCLCIKLYPTQMTIWALFVALCIALVYLIPVGMIQAITNRQVGLNVITELVVGYMLPGRPVAMMMFKTWGYITMSQAMIFTSDFKLGHYMKIPPRPMFWCQVVATVVAGTVQLGVENWMFANIPLICTPAQKDMSGFTCPNTEVFATASVVFGVIGPTLQFSKGQLYYPLLFFFIIGAVCPLAVWLLTKRYPNSWLNYVNLMFTGVGLIPPASAVNYVPWAMIGFLSQYVIRRRYFPFWAKYNCNLDVLSAALDAGTAISTLLVYFILQYPRNGAIGRDTIQQWWGNTVFKNTADWHSAPLRVVPPGDRFGYVWHCLFFGEICSAAPHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKL4</accession>
    <name>A0A4Q9PKL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_858069</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKL4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKL4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017126">
        <property type="entry name" value="Condensin_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="442"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="574"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="752"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR017126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU54671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="854" mass="93934" checksum="7A57B607943781BA" modified="2019-07-31" version="1">MPVSRHRTQREISRQSFAESDSGGDTEREQTPRPHTARNFSKKRLSERFDPDGSFNLDDATNGTSKARPPLKSVNINDDVAEKRRRRKSAKVVLPLDPDDEPEAGPSNSANSHDATDGAAEGSRAANLAKQKSQLLNVPQVPVINVPIDVMTSNFDQWMKMATDNKINAANSWNFALIDYFHDMSLLRNNTDNSINFQRASCTLDGCVKIWTSRVDSVGTETGKLLSNLANGGHDPEDGEGSDDPDGADPSQSQRKRKAYRSESTLAKNPAQLRTKKLELEFSVDPLFRKTCADFDEGGAQGLLMNHLGLTVTPDGGLRVVFDASDSVAKGEEEEQPLEEPRDEVDLSFLREQFIPNLDSIEEQEISHSLEDFAFGKDSFSMDNTTFFRDGALALDDDDDDGNDGFGDAPDIDNAMDVDGVPNSAAPVEDFFVGDQAIPEDYGDFGAEYGPDGDTTSVGGSDGAPGEQKQGQFVAFDPRHPPNERDFVMAVGEDGEGMANYFDQNYFKKNWAGPEHWKLRKVVRRPDATDAAASRPKREKKEAFRIDFLAPPEEDVKTRKKKLFAPVVRGAGINLPGPAASKKGRGKRGKGKDKEEKRNNQTLPDDMHFSTKSLVTLFLKPRFSLKMRGHRLRLDGVPEGEVNEAFWAQAAANQAAGAGGEAGDDSAIPFDTQFFHDDDFDDGPGFDDVDDGVDGGLPVEADEQDLLAATQGQTRRVKPETVNYAKRAKRVDVRKLKENIWKGLEIVAPPVEDGEDAMDTDDQQPTDPTEARPFTSVITGLQKTYTKDKMDEISTSFCFICLLHLANERGLKLEVDGKVEDDDEDEDAAVGDSNKVGNLWDLKVYRDPNAAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKW6</accession>
    <name>A0A4Q9PKW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_727990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKW6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="12854" checksum="868E68466BDAA628" modified="2019-07-31" version="1">MSSGPTQSRHGSHGTALTICHIGGVIRRVVQVKDGPPISKVLSNRPKMAVYPHAHGQATTSDDVNREAANSSSSVCSGRTTRGVRTLSRCSGGQEEDRQIITTKIDNHDPSAVWRSAEPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKW7</accession>
    <name>A0A4Q9PKW7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_935214</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKW7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKW7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU54746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="474" mass="52423" checksum="177BDEF9FF697286" modified="2019-07-31" version="1">MATRRGRFRTKLCRNYALGHCPQGDKCNYIHASPESIQTNIISPLLQPSLSQRSADDQFSSTTFSPSLWPTISPVTNASSDHFGYNWDTSTTAVDTSLPPSRMKYRPLSWRTTLCRHFLKNRGWCPLGEDCNYIHDLTLAEFAKNDVRFSRRGPSSTATAKRNERGKAGSKHSHCWAYIQGLCHVQDCRYLHPVAAHMFAAHTPCLAWPNCRRGPLCPYKHPEPYISSSPQASPVQHYTAIHPPPSQPDTVPRGAMLHNGMFYFNVGQPQPMAPSILQPPAPPLSGPQPPVVFTNPWETWPIKFTPPAGMAFTPFAFNPPTWQGVVPVGLADSGAGQQPMFSPVAGPQPTFDLAFGEPRPRQSMERPPNHPFRPAEVSATQRTSSFSVVTAPPAPETEFPYVPPKNQRVGHARRVSVTIKSKEDLDALGLDSSSSHGRLPWQTHADRVARRSWAPSSSSFRTAQATPPPVLYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLR4</accession>
    <name>A0A4Q9PLR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLR4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLR4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="15000" checksum="291297B4E1857CFC" modified="2019-07-31" version="1">MNPGNAASLSLERAPDHPPLRLRARRLQVYALLLLSIFTRLNHERAPMKLFTHRDFVFTLHGVVYLRYNSFATPHDLKKQVCAYNPTRFEIGLVYFARTVRSVAFAPQLRELIINMGMFDCVTADICCRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN21</accession>
    <name>A0A4Q9PN21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_933309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN21"/>
    <dbReference type="STRING" id="114155.A0A4Q9PN21"/>
    <dbReference type="OMA" id="CCNDNTH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020911720" description="Hydrophobin" evidence="6">
        <location>
            <begin position="22"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU55661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="135" mass="13476" checksum="B3EBD1E606D5D221" modified="2019-07-31" version="1">MFSRAVVAFCFLLPLSVPAAAKPWNNTPPVSTTATATVTVTVSAPAPTPTSGDTCSTGPVQCCNTVGSANEPPFSGILGLLGIVVEGAESMLGLGCSPMSVDDDGSGTGCSFNVVCCQNNNVGGLFSIGCMLIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNU5</accession>
    <name>A0A4Q9PNU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_908134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNU5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="438" mass="49440" checksum="4C29B8FA5CFC226E" modified="2019-07-31" version="1">MAAKHLEVTVPGPPGPTRYQLWFIGGNEVGAFLMEAFQSASELPGRFSGRGYHKPEIDALKQNWANLQDDEERARFKDDKAAFVTENRKVSCKDKRSEEVYKLKKERLEAIEVRPRQEGFGEVLNYMQYSDLAGLKRMSSVNRPSKLTEKGTESGWNLIRTSIVQYMTPFRNKYIREQAEILETPTREATPVVDPFEIMPKTRLEHFESSLDVYHRANSPRTSSSDCQPGFFELATLPVMQAALLQDTSSDVVQEFQTSPVDLSSLIISWTDHHRNVFTELALLGLDAPYRGEELGMFDDHVAVTHAIISLGGFAPDTATHKDVEEAGISIGKRQVFNWQNAILHTIIDHPTEGLDIPSYWERLSPDDAVKAKALESALTQHNSAITTLFQNPLIVFGCEWCRWHGSIADLDIHLLSVHRILIPAISIELALQPRSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP44</accession>
    <name>A0A4Q9PP44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_932136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP44"/>
    <dbReference type="STRING" id="114155.A0A4Q9PP44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="57"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="801" mass="89170" checksum="37F21830CE2CDEDA" modified="2019-07-31" version="1">MLSDWESSLTEFSSESDDEYVPRAAPKKKPKQTAEYKVTKSLQPYRTTTYTAQSLYDQIIDNTIDLDPEYQRDIVWGEAKQSGLIDSILRNFYIPPVIFAVTHNEDGTQRRTCIDGKQRLTSIQRFMDGKVAHKDIDNGKKYWYKKIDNESRALISKPLRQTFANKQITCIEYDGLTEDQEREIFQRVQLGVALTTAERLQAIPGPRPALIREVQSIVLGEDGFGSDLDWGHDRGRDFQCLATIICLIESHPNITFPGSPKLEKWLSNAKLVDDKTRKDVFETFQIFITLVKDKKYNAAFKKPSRVSPVEFTMTGVLIYLYKKTYSLMQLSSAIWQMRADVRKQFADVRANAKVTKAMFQFLDKGVKGVELASDGKGDIPAATAIKTMDSSARAAETDEDTPEPAPKKKKQKRRRVQEPPSSDDSDYEAVRPKRRASMPEPQASTSSSAVPKAAASRPTAARKVSAPVATKMKAASKAAPKASTRSSTMSQPRDGPSSSQSSIPLGGFATAMNNFTSRKTRTAMSAAADSLLAQAPIAEIGTTSAVGSGKQAVETPMSAVKMEIDPPRLRTPDANDDNAMAIDDASNTAQMDSTPIPRSLPRSGKRQLTANVAISRMEPHPDLGDIDTGAIEQMLKLNMKSAQGTPIGSPVVPAPPPPPSISAPPMLGALGQSASTILPRRTAVDTSSSAQATHMPPPQSPILPRTDHVRGRSSDRSRDGDRDRRERSRDRDRERSRDRGQHDFRGSARTAADRNRSRDRDHDRWREPPTREWQLSEAERRRRDRSRERDRYGYTGRQRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPN1</accession>
    <name>A0A4Q9PPN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclease Le1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_932165</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="358" mass="39018" checksum="59FFA479F7ABF71B" modified="2019-07-31" version="1">MLRKLVVTSTPQISQQQIYQALTSRTALKMLTLLAGFSVVAFAQGVLAWGNLGHETVGYVAQDFLAPKALAFVQSSLGSTYNETLGAAATWADSIKYTSGYTWSAPLHFVDAEDSPLKGSCSVEETRDCGDSDCILTAIANYTTRVAKTSLSKAQRQEALKFLDHFLGDIGQPLHVEAYEVGGNDISAKCSGKDTNLHAAWDTGIVTKNIDDNHDGDVQTYAADLVAKIKTGSYKSLTSKWLSCTSTTEPVEKRFLYQKSHTLEDDVKALLARAEAEEADVYLERRATITPLECPLVWAQESNANCCSVVFSYTSGEDLCTSSYYTKAVPVIDLQLAKQGYRLAAWLNVIFDGDTNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ91</accession>
    <name>A0A4Q9PQ91_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_612483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020245223" description="Secreted protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37674" checksum="7CC5F55BB7A0F400" modified="2019-07-31" version="1">MHRSTTPRAPRMHLAVILLSPALIQRSGQSCWPFSPGEYSSKRPRARSVRRRPCSPGRPNRFELAATIDGRENDARGRAEKPAVGRSKPTLLSPRRLPFSISEDPASWPTAQLRRAARRSASSSRILFSYPFPFAGRSVPSPWGEKADEVRGTPCAQRRRSTEVRPPIINLIQIVSDAHGCTRSRRFLRVPLPRPTPQPCTVTCSLGVARSGSAACELFDGLDRGDIGTPVSDDVSIRVAGRETRDTRRSRGQLARCFQSRILSPRVRSHAGVAAVTYRVLCVNIAQDALYAHVLLPSSCVGDRRVCCLLVWTYPCAPAGNQLGRTLNVAPLTWRGVSLENI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRE0</accession>
    <name>A0A4Q9PRE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_815991</name>
        <name evidence="2" type="ORF">BD310DRAFT_822673</name>
    </gene>
    <organism evidence="2 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRE0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRE0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF1">
        <property type="entry name" value="F5_8 TYPE C DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="OmpH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="238" mass="27670" checksum="D8EE8246C8B9B3C0" modified="2019-07-31" version="1" fragment="single">LPLIWHQCLPEAVKDYQSAYKKYETALQKHNDAAQKHEADVQALRTQVTSPDLNPRQRTKLDKKIKELVSKGPKPPLEPTQRMQDAEVPLMLSLGAALKLLLGSPTSAMQRQRGTQLLLSYLQEFKRIYGVSAMVPNHHFATHIPQQLEDYGTVYEIWAFLAERLNKTLKSTNQNNRRGGQQEVTMMREFDRHMQVRAIVRTFHCSFRRATDVTPALHRLNMHQHLHQMEPMKLRYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRG3</accession>
    <name>A0A4Q9PRG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_907429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRG3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="216" mass="23733" checksum="A954C64E0C7E980E" modified="2019-07-31" version="1">MSRLRSLVNNLPAYMHLPADIERIYHDVSHNSPTPTTPYTILTGLSSYTPYLRRGSCDEDALAANSPDEELSMSAARSLKTPLQNRQAKHARRRTSPRWTLPAEPDVIVATTGIVAACRQSSTTVHWSSPALRDAAMGRGARSRNVYLTFKRFMCSHHTMCPPARPSSPQRPGAMASARAVHAAWIIGPALGRGMIKLLEGRKHAQDPTLEVGRTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT50</accession>
    <name>A0A4Q9PT50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929096</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT50"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="194"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="362" mass="41370" checksum="B4D762C366F4F505" modified="2019-07-31" version="1">MPGTTSPSVPRWVASPPTKEALDWAELPVIDFSKANTLEGRAELAPRVRDVMRTVGFMCIVNHGLTHSQTERMFDIGDVVFSQVPEEEKIKFSSKLKEEGTRIGYKPRELFVTDNGVRDQYEQYAVHRTVFGRQKHPKALETYLPEVRVFAEHNHRDVLQNILRLLALGMEIPEETFVKMHGFDAVGDSHVRWIKYFPLTEEDEVKTNHVWLRGHTDTGTVTILYSQPISALQIQSPDHKWRWVKHIDNALVVNIGESMEMLSGGFYKATIHRVVQPPADQRGLIRLGMYYFALADDDVKLVPVDSPVLEEGIRVSEDETGLTMEELRKIRYRAFGLKEANMEAGGEEHIVENGIVVLKYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTK0</accession>
    <name>A0A4Q9PTK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dolichyldiphosphatase</fullName>
            <ecNumber evidence="6">3.6.1.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_928714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a di-trans,poly-cis-dolichyl diphosphate + H2O = a di-trans,poly-cis-dolichyl phosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14385"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="EC" id="3.6.1.43"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the dolichyldiphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.43" evidence="6"/>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTK0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTK0"/>
    <dbReference type="OMA" id="LTVYQHE"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047874">
        <property type="term" value="F:dolichyldiphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF1">
        <property type="entry name" value="DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU57791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="234" mass="27322" checksum="BE04921447A93AD6" modified="2019-07-31" version="1">MTSRAALDLTYVLYDDSSTTSYILALLTLSPILLNPAYAVLTVWTRELVFLEMWAGQMLCEAFNWALKHIVREERPNHDLGDGYGFPSSHSQWMGYFLSFLILHFSLRHRFVPTGSKVLNWARDIFLFTFITSWSVGVAYSRYYLSYHTPKQVLYGFSIGVTFGTFYYLLTEFVPVRFPNSPLGRFRTALLTNPLSTWFRLRDGWSVWSDAGTEAQYLVWRKEWDRKRLAAKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUW7</accession>
    <name>A0A4Q9PUW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_819503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUW7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU58392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="564" mass="61267" checksum="DE46407E52DF3260" modified="2019-07-31" version="1">MSSPLRSPRSSDVDDTPRKTEESVAVHSGSPDFAAEVEAAAPLLKGPRLTAAIAFVAGTGFTLFGYDQGVMSALLSAKQFEDVFPQVIVDSNHPSNDATLQSFIVAIYEIGCLIGALSNLWVGDWLGRRRTIVLGGIIMIIGAILQTTSFSYAQMVVARIITGLGNGLNTSTVPSYHAECSPAARRGSLIMIEGSLITLGIMISYWIDFAFFWLSGSSAQWRVPIALQILLAFMMIVGIFFLPESPRWLAKHGRNAEALAVISALEGKPHTDADVHQTYHAIKEAVAAETHFGNDSSPLREIFTGGPSQNFRRAFLGVVVQCFQQITGINIITYYATLLFERLGIDDVKARIIAACNGTEYFLASLIAIFLIDRVGRRPLMLFGAVGQTITMILLAVLGRIDTSGTQVASAVLLFVFNSFFAVGWLGMTWLYPAEIVGLRIRAPANAFSTASNWTFNFMVVMVTGPSFNNISWRTYIVFASLNALLIPVVYLFFPETAGRSLEDMDVIFALAYKEGVSPVKVSLRKDVPAAGSPEADEILGITTSSRIGSFREDAVPRENEKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVE6</accession>
    <name>A0A4Q9PVE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_484931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVE6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="9939" checksum="589A7428C7CB366F" modified="2019-07-31" version="1">MLLTVRLPRHVRMPWPTTLSGPAAPSALGSGLCTEPYRQPTSASKGSSSTRVSAITTISSALKLNHARRLTPRPALAPARRTSSQVLTPGSYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVM5</accession>
    <name>A0A4Q9PVM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVM5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="84" mass="8925" checksum="9DDB967BC51C242A" modified="2019-07-31" version="1" fragment="single">MTSGALLDPHYRQNVPGTRLRRAPSSFATTLHSSASHGRLKGPASGAALPHPDCLHRPQHADRCGQTDAARNSKPATNDRTCAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXA7</accession>
    <name>A0A4Q9PXA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YT521-B-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_423819</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXA7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXA7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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        <location>
            <begin position="821"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="1001"/>
            <end position="1142"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    </feature>
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        </location>
    </feature>
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        </location>
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        <location>
            <begin position="1038"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1143"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
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        </location>
    </feature>
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        <location>
            <begin position="315"/>
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        </location>
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    </feature>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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    </feature>
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    </feature>
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        <location>
            <begin position="979"/>
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        </location>
    </feature>
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        <location>
            <begin position="1053"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1187" mass="128450" checksum="6A8188E78793B641" modified="2019-07-31" version="1">MRATFPSATPARDLTPKPEAQLRHSPASAASSHPSPHSHSHSHSNSPRRAVRTVEPSPRPSSSNDLRSAHISGTSDESPPQLFRPSLSGSESEDSATTPTRLPASLPPLLNVVYDASTTSFHPSKPAVTSFENSPERYIDLLHLHDDGNFYMSGDASSSSTLNMSDSRSAGSTSDQGRQPHRGRGMSQFGQSRRPPARPVFPSQTPSHPSPIPSSSRENRVGASVAAPSFQSPPPQYTFGQRGAYPGQYAMSQPHMGVVHPSQPQFAYPPPHPGLHAHDQSMLSPPQNQLMAYSPGAHPSMMQTHSQVYPYPPHSAESSSSSSRSHSFVSSPTAFPLSSRSQVHPAHPSPPPQSPLAPPTSGPPHSIPTSLPPHSASFVGQPPYSPMRYSTPPFAYPPHSFAHSPSLYAPSYPSPYPQPYPQPGPEQENQGTWWYLPPHPGSGQFESFQSPYAMSYSPTNTREVEHPQYRPHGSSPVASTLFPMAPPYPARPSPGHSSSSAAQSPYSPTAPSPQLSAYGPRASETPATVQQPGRPPDHTPVSSGMSSAASSQHSAERPPPVRRPYHPNPPAHRSEWVMWAGNVPSDATKEELWRFFNSPPSPGSQVSTGAQSAGAQSTQSAPAGPVASSAASTTDSSTASTESVFGGVSSIFLILRSNCAFVNFHSEAHLHAAIEHFNGVPLRSDDPRCPRLVCRVRGREDDLKSGVGGQRMAHVHISFAREQREREAARRRSASSSSDQITTPSPSSPTDPAGLLRGLSISSDEEAGTGRRARKPEPHSSSSGSYASTNSSILTAYFPKRYFILKSLTQVFPSLVSLRCVVFFDRPGPGQFDLDLSVEKGLWATQRHNEGILDQAFRTSKEVYLIFSVNKSGEFYGYAKMAGPIMRGEARVSWASRTDSPQHRASQETPRDSPMATARTGETAYFSPSENRYGESPFPMSPETQKQAATSVPLSFSQQVDRNAASAPAVLHRPHRALSQATPEDTQTHSYDGFSIRPAIPAIAGHKQQSEPGGVELDRMAPIRAIRNPRERVAEAVRTLEESPLHTVAEEDERPHLEEDPGKGKAVDRTPSGAAPTASAREQEDGPAWGESFKVEWIRTERLPFTRTRHLRNPWNHDREVKVSRDGTELEPTVGQALLEEWDKLEQPQPPSAPSGHVEVGRHLQGKASISADVLSGPESTRKTGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXD3</accession>
    <name>A0A4Q9PXD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_877496</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PXD3"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045717">
        <property type="term" value="P:negative regulation of fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="DCAF8"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574:SF40">
        <property type="entry name" value="WD AND TETRATRICOPEPTIDE REPEATS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15574">
        <property type="entry name" value="WD REPEAT DOMAIN-CONTAINING FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="WD40 repeat-like"/>
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="479"/>
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    </feature>
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            <begin position="524"/>
            <end position="559"/>
        </location>
    </feature>
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        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
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        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="559" mass="62104" checksum="84014206058A632E" modified="2019-07-31" version="1">MALDLLPSGSLPFLRDIGATDFISRSAPIHARRRAAETILCDGLPYSKKLVGHTSCVNSLAFSNDGRWLASAGDDPYVQIWDFHQEQLSKPALSFLGPRSNVFTLAFSASARFVYSGDTSNILHQYDISSLHDPVARVEAGSQAGSPSWSNAQHDDSIRSISCHPEQDNLFLSAAEDGRIVLHDMRGDSRYTRTQRILQHRTELTCVQYHPTMPDLFATSDNHGQVCLRDVRMAFGPLSQRRDEGVVHKVRLPRSCMRRAGHLIVQQYVTTVAKQGVANKARPEASSITFDREGRRLAVTTLHHLPTLYALNDPYPIALFSGRRYPNGAVVNPSENTYTNSCTIKHGSFGTLGSDRDMYYTAGSDDFRAYVWKIPEEAALLESRNVVEYSDWTENRRPGELGYSATALGPRYVPQEISTPLARLTGHDSIVNTALCHPHHPYILTAGIERFIRLHSPTEASPCTEPMLPTPKTVRTVSFSNPSSRELFLRAVGMVDDPDVEEDDDDSQSIALFDQILRMEGNGDVFTVRRRDGHRDGGDSSDEDMDGGSDSDAEMSLYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZT3</accession>
    <name>A0A4Q9PZT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_923061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZT3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZT3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF72">
        <property type="entry name" value="NEUDESIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="165" mass="18656" checksum="FCF5F73B7A293BAF" modified="2019-07-31" version="1">MAFDLGTPVNTALLLYILYSIQRILFPSNSVPQIVPNEFKNGYTWMPKSHPPTLLYQTFTPKTLAYYNGEDGKRILLAIKGVVYDVTAGRNFYGPNGMYANFAGRDASRGMAKQSFDEEMLTPIDQPLDKLDDLTPEEIENMKGWMEHFSSKYIVCGKLVENDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZZ0</accession>
    <name>A0A4Q9PZZ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZZ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="61"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="624" mass="70743" checksum="1846DF9AEBEC96BB" modified="2019-07-31" version="1">MSTKTSDLPISEFASILPAADLADLAGLCASAVRERTLARAEEYRRFALALHSVHNAVLPIHRLPFELLSTIFRKAWKDRSSLRMAHVCRRWRSTALQTPALWADAIACTSFTLAGPDHVVPLRYSYMDTLLERSVPRDVRMTICYFPKALRFHLLPHISRIAVLDIKIHSANQLHNLWETLRGGMSCLEGLYILCPITDYHEFIDYPPRTWLNEWGSRVACKALPNGSLPRLRHLRIPGALFPLIACGTLTHVTLHNPRPHKTDIRLPSVTRLHKALGKCRETLEVLRLIQVLPTPQPTRDTAIGEHREPIHLRSLCDLLIVEERAFASGPLVGLILPPTCRIHLSDGPCTDHPCPWGHDPGPDHRVWLDPDQRSLEAVHSLLSGISLVKLEIGWKFTMRCYTQDGSAHSLSERFRAETFVRHSRVETIVRPLFRPKIPMLSVNVTHLVLSIIDGWYSEQPALFEAFPHLLRVEIDVKEAGLWETLYLLKGPGEGNSDGTGSRGPVCPSLRELVMWVEVPKGSLRPLLESPNLGDFEEYVAKRMRQFRDVLEWRAFKSPSPSRLTYLKIHQHEEGSLKTRGRTVVEDDLSSIESKVVQACFEDLYALVDGEVVFKGFRNFTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q034</accession>
    <name>A0A4Q9Q034_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q034"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15825" checksum="B0A01EBA4025E376" modified="2019-07-31" version="1">MCTSGDVGDAQRLSVLRRWPFTAARPPVSSIMLSTVQSEFAVRRTRNSTYASSSRPPFACSFNQGRRQRDVAATRFGPSRTACVPPAPPLYGCSALGISRPARLQRRLLAIGELYIFILMVWWVGARREVERVRRGGNGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0K1</accession>
    <name>A0A4Q9Q0K1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_922985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0K1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0K1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="93614" checksum="DB58F50C7AB4D85F" modified="2019-07-31" version="1">MPNLLTAVRSSLVLLVIRLRRWRASVFLKHILVLWLRLKRFLLSRLLGRSPKPRDGREGSSGVLKSRSSGRREITSPAETSQELVWHNHQPADAPRSQAEVVTVCESRRPLSALDLPLDHPHAHFLQPGDIPTRPASMVLPGQSSVHSSHDMLHPYSYTHSNGSKASNVSTDVHSTNDVAHVRGRHLGVAHPRPEGRPTSRAAARGISRVASRAPSRATSHSRTSRAPSRTPGPSVVDLSIMPPRSPGPAHPQLPSSPSSPDRQTIGSRQSVVLAGDIAEPTPDSLPSIAISLPVERETIYPTMTIPRYDNYATVSPDPGDWTLAPVATHLTIENVPLDWVACTHPEGRLYFYHPRRRIYTDCDVRESSTLATLITFARIIDEMVAEQGLVLPPNCELVLFLEERRISGGYNWIYYFVDHSSRSLFWVQECHPIDDLLIHEVTALNAPYDIKCEVEAKYWQHLEMYPYGHRIPDEVLTELTGMLLFASIDAITSMTTTVTYSKDEVHRMLGLVKSAKAVQGTDYATAAVGRLMGIWIHNRFLNFHGQTHARLGRDQSVYNNVKTRRTPLIRILAPFFWNAPEVHLRGLEKIWVDGIISIIPWGSFIGKLQNEWQEFVLYSTVLLNANVAFLAIPSVDSGNGHVTAAQISSYLSVVTSVGSILLGLLLIRQHRVKSKETAEEANRFLSSRKHEMLGLETLAIIYSLPYALLMWGMLTFLLAFSFECFGSNDRTAIFTTAAVWIAVALLVGWTIFTGWESGGDSSVWDILHRLWDRLFPAKEPGEEIVTEAEEGRTTAAGNEKTKLARWWARRVRPPQALPHSGDPPSTAPTPASVPEIGSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q246</accession>
    <name>A0A4Q9Q246_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_769509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q246"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q246"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="36"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="247"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="382" mass="43625" checksum="6AE8147134C05931" modified="2019-07-31" version="1" fragment="single">MPSEGASALPTIAEIRARTLEKFGRRPCLWQCNATLAQLRGDKDVVCISGTGSGKTLTFWMPLLFRPDGIQVIISPLNILGTQNTEQLARLGIPAFAFRGETATAENFQAAEDLQFRVLVAGPELAVRSSPGSGFDRLWRNDRFMEKVISIIWDEGHCVSAWGHFREDYLCAARLRHIMSRVVRFYVPSATLPEHVLVDVMSILQMQRGSVELIRRSNDRPNVFLSVQRIRHPLASCKDLEFLIPDDWKPGMHIPKFLVFFDNIEDSVRAAELLQNRMPREERNRIVWFNANNSHEFREEATKEYQEGKLYGLYSTDSFGMGVDITDIELVVQWRTTCDLNSLWQRFGRAARDPSRTGLAILFVEPRHFNEEKIEAAKRAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q373</accession>
    <name>A0A4Q9Q373_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_920532</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q373"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q373"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="369"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="452"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="496"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="581"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="623"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="665"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="703" mass="78694" checksum="9DA7A29669C84DE1" modified="2019-07-31" version="1">MLNWLANMKSPMLPWEVIERIVSHCDDSQTLRSFTLSCRQLYPRSFCFLVARIDLMSRDDVFAFCEHIQANPHLGPLVQELTIDLADFAPFPLLYILPNLSQITFISRGGHYAPFSHRMHQSIFACCQRFGTGIRTLRLTRMNSWTFQNLSRILLAFKNLRVLVIEDVHKFVEMGGNTGHTQAIVQRLSQQLRLQSLAVTDEWLGDTREVALLLESAQSSLERLSLGVPYSEKESYVAHLLISTQPTISTWTPLRFLTLKTRLNSKDIAGIIEILNGFHPPNLKHVTLDMKLDAIGKLIQWMGGAGRQSRQCHQTEQALLQFPHPEITFSIKNPIRSYRIGFWNHELGIRLPILRERGKLSVISQSDKTPGHDAWVQCLVYSPDNKRVATGSNDNTIILWDKEGQISRQWVAHAGNIRSLAFSPDSQYLASAGEDELAIWNPSRSAHEVAKLDGHIGSVNSCAWSPDGTVLASGGSSGEVRVWDARTFQLLHVLVDPHHSHNVWFVCFSPDGRWLASGGWHDNCCLWDVVVGKLHKVLRDVEPFRTPAFNPESTCLAVASHLRMVGIWSVQTGESLFEFELEQHTMGVSDVAFSLDGKLVLSASYDMTVKIWDASSGVLVSSLEGHTGRVNAARFSPCGSYVASASQDGTVRLWKMSDGSCASIFTEHKDFVQYVAFSPDGDTLSSGAADGTVLVRRWREFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3F2</accession>
    <name>A0A4Q9Q3F2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_956665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3F2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3F2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="470" mass="51436" checksum="09239EFEF9DEEA30" modified="2019-07-31" version="1">MGWDLTPPRGTESLQRARGASWGDKGIVTNRRVNGRASVSATHSLRDGEPPGYDVIRKEGDFPNLKFFTERQWNKYKRDNPKTTRIGEEPVRGRKMSAQGINHTAPYVEYPDGTPAEGDYINDARKFCRTLINLARGVQYPLPKKWGDTDTWLQELFLTALRKKFPLFQLCHNNSKGHAFMYYTYYEAVTRKWDKASSQNVDLNQALHTISAGSDLEESESESARRRDVRRTGPSEKSTSVKRPSVDDDVVAGPRKQARTDPGVPRQIVEAPPAPSKAWKGKERAAPRLLTALQLDHRPSGLVAPPPSVVPPPDTAPASTSASSMATSAQSTQPPAIALSPLASLTTLTTVSGATDVVPAPASPPTPTNPEVPAEGGVDISASPPQDMTSMGTAPPNEHADKPSEVTTSKKTRGPRKTTQWPPPPDLKGAKWVYARKWYTDSNGTLEAFEAHYKTLSSSDRRKLGRVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4W3</accession>
    <name>A0A4Q9Q4W3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_153959</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4W3"/>
    <dbReference type="OMA" id="LSECHTR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000008">
        <property type="entry name" value="Cathepsin D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020709722" evidence="6">
        <location>
            <begin position="19"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="112"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="421" mass="44062" checksum="E7F5D83A478B2DDE" modified="2019-07-31" version="1">MFCKATLLTVALALVASASPIAREPAPSGIRIPLQKRGSLKNADGTFNHEAAVREIVKLKNKHRQNLINLEKNVGRQAFPEGAEIKPLATVPESFQKRGAVKLTDQEDDLEWTGKITIGSPAQSFTVDFDTGSSDLWVPSSSCTTCGSHAKYKASSSSDSSKKSGSFSISYGDGSTASGTPYTDTVTVGGVTVTGQYLAAVTKESSEFQSDPADGLLGLGFASISNLGHDPFFFTAVDQGVVDQGVFAFKLASSGSELFIGGTNKDLYSGDIEYHDLSSDDGFWQIGGASVSVNGKTEASNFETVIDSGSTIITAPTSAAKKFWSAVSGSKVYDSSQGLYSYPCDSAPEVSFSWGGKDWAISADNLSLGETESGSGECVGAISGGDLGLGSNVWLLGDTLFKNVYTVFSVDENAVGFAELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5F4</accession>
    <name>A0A4Q9Q5F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_919991</name>
        <name evidence="10" type="ORF">BD311DRAFT_763481</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143452">
        <property type="protein sequence ID" value="TBU26014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5F4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5F4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU26014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="551" mass="62009" checksum="A8B90805D85878C6" modified="2019-07-31" version="1">MLSSAILQAVLICGSTLFLWRLFRQLLVKSDLDNIPGLPSPSYLYGHVQQLRDKQGWAFYRELAEKYPAVARLSGPLGRKLLFVHDPKAMHYIAVKEQETFQEAEWFTSLTNRAFGPGLLATQGDHHRKQRKLLNPVFSINHMRHMMPTFYHVTHKLREAIEQRVVQGPTEVDMVMWMGRTALELVGQAGLGYSFDKLTEESADEFGEALKSMAPTMATLGVFLQFLPLVEALIPECLLEPLGKIAPIPGLRDIMHISKTLKQKSTEIFMQKKTALLQGDEALAMQVGEGKDIMSVLLRANMTAAVEDRLDERELIGQMSTITFAAMDTTSNALSITLWRLAQNQQVQDRVRQEIFAARDSQGGKDIPYDDLVSLPFLDAICRETLRVHVPAPMRFREARKDSVLPLSEPIRGLDGKLMHEIFVPKDTHVFVSINASNTNPAIWGPDAHEWKPERWLSPLPETVSNANMPGVYSNLMTFWAGGRACIGFKFSQLEMKVVLAVLLSTFKFELTEKAIYWNIAPIVYPSVVPDGSKPELPIKVTLLDRDVTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5M4</accession>
    <name>A0A4Q9Q5M4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_59186</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5M4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13882">
        <property type="entry name" value="CuRO_2_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020181058" description="laccase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
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    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="31"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="164"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="366"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
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            <dbReference type="ARBA" id="ARBA00010609"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU62599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="520" mass="56477" checksum="5571608FEABF05D8" modified="2019-07-31" version="1">MSKFMCLLSYVTLLFAASAYAGIGPVTDLTITNADIAPDNFTRAAIVVNGVFPAPLITGNKGDRFQLNVVDQLTNHTMLKTTSIHWHGFFQKGTNWADGPAFINQCPIASGNSFLYDFQVPDQSGTYWYHSHLSTQYCDGLRGPFVVYDPQDPHASLYDVDDDSTVITLVDWYHVAARVGPRFPLGSDSTLINGLGRSPSTPTADLAVISVTQGKRYRFRLVSISCDPNYVFSIDNHDLTVIEADGIETQPVTVNAIQIFAAQRYSFVLTANQTVDNYWIRANPNFGNVGFTDGINSAILRYDGAASIEPTTSQQATQNLLNEATLAPLTARVTPGTAVQGGVDKAINLDFNFNGTNFFINNASFVPPTVPVLLQIISGAQNAQDLLPSGSLYELPINSSIEISFPATTNAPGAPHPFHLHGHAFAVVRSAGSTEYNYDNPVWRDVVSTGTPAANDNVTIRFQTDNPGPWFLHCHIDFHLDAGFAVVMVEDIPDTTSANPVPQAWSDLCPTYDALSADDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5N5</accession>
    <name>A0A4Q9Q5N5_9APHY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BD310DRAFT_843694</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU62605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q5N5"/>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Tropomyosin"/>
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    </dbReference>
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            <begin position="148"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1346"/>
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            <begin position="388"/>
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            <begin position="489"/>
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            <begin position="647"/>
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            <begin position="757"/>
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        <location>
            <begin position="174"/>
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        </location>
    </feature>
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            <begin position="1353"/>
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            <begin position="1596"/>
            <end position="1608"/>
        </location>
    </feature>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1617" mass="179858" checksum="B2BAA84DD2D84CCD" modified="2019-07-31" version="1">MSTWGVGDNHDSEEVRLLKDQLRVKDAANATLQSQISKREAELKEVKVSMNEVLVKLRKDADRVVQLEADLKRRNEDLSNERITRANAEAALTTAERKLKESEQNALELQSTIETLSCQANSTSLGRSKLEQDNTALQNRVRALERELSSKSQAEVAALSRSQGPSGARSRRPSPTEDSFRIPALEKEVAELRATSTQRASELERTTEQLARARDQLVQLQNERTASERQLRRQLEAAQAALEEREDELQLLQDARGGEDIAAREAGLLERLEEEEKRVAALEAELARSTGSRKRDMVMLQDELDRTLQLLDDANQKLAAAEGKLNQLSRDREAAYRDRDRLQRERDQLSESMHEAGMRISHLELQLSASSRGSAAEQAVDEETAATVERLLNKIERLRGERDDLRRDLEFLTVENKFAVQSLEAKLVAATSAPVTPSVNSTQISQLSSLEGYIQLLEGQAERTSRASLALAIVAQRTTQHEEAKMARIQSLEDELATTRKSLQQAEHYLHERQGAIESLENQLSSSTSSVGEAESHLAGLRAAIQRLEDELARERNSHAETGAALSDAEAQLNAISQTLTDAEAARDALALEKTHLEADLETAKQELADAEERYTTQLAELAAAGESGRGTQVALRAQLGEAQDRVQRRTQQIGELQHDVKRLETNLKLQEDRITELTAELDVAQGERVAMLEDCRATREERDDAMRRCDELEDAMEGLEEAREREVEAVVRVAVGAVASRREAIVRARKATGNDHAVLEERVRLVEQEKAELSSLLASLSAERDQFAQTAEHEVSSARAELEEIKSAAQSQLSELRNQLEAKDRELTSLQNQLTVAQAKHEDRQSLEASLFAEEKADLETRLQEARASHAELEILHRETTDKLRSVEADLKRAEEELASQLANNAAHSESEERLREEIAQVKEGHAKEIDSLEGQIKNLNAELETSLRLRGEADASRQAVEEELASTKEQLAARLAEASETLAAAERLEVKLAQVKENYEERIRSLNADLQSLTVELQDIVRQKEEIVIQYERTMEDSRAHERAAAEAREKVEALESRLAEVKETHEELTRGLQTQLDDTRRDLEDAKISADAQQRDAIDELTRTVEELQGRLTVLTREVDECRAELDEEKASHARTRESTMSEMREIIAMRDEAEAALSEAEKELPGLRGQLEYAESSLRTMEEEKANLEYQTTNLEAEVQRAKSLQRFLESQVAESEHRIASLDAELTELRAKCTTLDKLAQSKEANLAMQTIQHEQTVASLKRELNALRIQPSYADELAELKEKNAEYEELLRAKCLEIEENDDKFIDMLKEKKKLNKKIETLSQKVQNLQAKLIAATEAAAASKTSSPPPPAPPPKPPSVFSPSTTLAPAPIISGISTNYSRPTPSSRQRVVTAPASRFSPENVPPPPMPVYRPKTPESRLRMMSGPSSLSRPKTPESKPSHMPVFKARTPERHRLPITTMPEAPSSSTLIGVKRRAPDDFDDCASVPPQTFTADSAPLGLTAEGATPPQPTTPRLRKALQSMRSGFTPMRQAGSRVGSVSPRRATTGTSLAAPLPHTISDVTNSPRAASQPDPAKVAAKKGWLGKIKSAPSSQPRAFSSRQPVFDPPGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q618</accession>
    <name>A0A4Q9Q618_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_945685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="TBU62842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="417" mass="47711" checksum="62389680752A3C91" modified="2019-07-31" version="1">MSSTTLLESFCSLPEDILVRILLSSELDAVVACKRVCRRFQRLIDGDIYLQYKIELALNGMIDGPQSYPMSVVERLQLLREYSKKYHALYFTSSEFKYSWQLWPRTGTPMTGWKFFLGFGGTISYIVVKPAQREISISVPPLFTGLREMRDWVVPYDAFMENVDREILCASADVSQDLLLVAVHGEDTRHITVYLRSLDDAERPHPCALQPTLPITTTEDLYPFTWDHERPTPLSMKSCDVQIHNNIIAWKVVVGVDVADPSDVEIWDWTEGRRIYHSPQNPEDSFTLIDDAHIVHEEWPLGLLLKVPPAHTLVSIQASSIPSPPSSDPQPFWTNPDLRVVVVRFVKEVALLIPYQTFRDALSVAVSPKQNPPHRAPYEYSIAWKDWIPRGALLVHIPRAESILHRWSVQHCYAYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6V3</accession>
    <name>A0A4Q9Q6V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_698574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6V3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12869" checksum="C47EF4545A31ACDA" modified="2019-07-31" version="1">MFRYGCFPAYWSRYAPQTQVIANSDSIDVASHQIIYLTAGDNPHSSIHEMTTVLLFLSAPQAGRASQAGRDLTRSRLPNYKFPGCLTGKDFSITSRRLGSNVKYIATLFAYQKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8F9</accession>
    <name>A0A4Q9Q8F9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Membrane anchor Opy2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_628099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane anchor Opy2 N-terminal" evidence="3">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="287"/>
        </location>
    </feature>
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            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
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            <begin position="419"/>
            <end position="517"/>
        </location>
    </feature>
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            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
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            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
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        <location>
            <begin position="226"/>
            <end position="238"/>
        </location>
    </feature>
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        <location>
            <begin position="246"/>
            <end position="258"/>
        </location>
    </feature>
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        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
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        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
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            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF09463"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU63336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="594" mass="62879" checksum="F9A3F8644308E1A8" modified="2019-07-31" version="1">MGRDRSCSRRHPTLERCRLSYRHRSQRAGHRRARFPFPCIPSPVPSRSFRLSLSSPSIMLVGNLNSAHLNRHLPRQANGTRGSDGCLICDDLQPSCNCAFGQQCVLITRLCDQCPYASCIAGSSSVSSKKGGVSGGAVAGAVIAVILVLAATVAGYFWYRRRQRLAAQNTASDESKPDVPARAEEVLNRPDPNEKPNSPPPQLSSIRIFSGSLQGTINLDPAASTAGRTQPSSASVHSNPFEDNHSIQTTSTGTQSNVIPIALVPPGSVESGASSAQSAEHNAPQTHANARSDMNLDHVNVSNDTLTPPGAAYVPSARAGGDNTINRMSYMTTGSYTSDFLETSVIVTPTRGTVKQVVGVAKAEVLRTPPSDTLSRASTLSRQARSPLANSSFGPADIMHEEKEEQEQEVTVQANPFSDNHSPYSNALQAHSSNSRHVHLKTSNSFPFVPPSPISNLPPRTPPRSPVTQQSFAGAQDDRNAQSAQEMVNRARASASLSSTISPLQPPNRKALGMSVASNGSTASNGLGSFPFQIDSGAPEASNVSTAPSSFSSSSGGSIAQRKRASLDTLALTSDLSSYPLGFDKTPAPPVPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8G5</accession>
    <name>A0A4Q9Q8G5_9APHY</name>
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            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
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        <name evidence="6" type="ORF">BD310DRAFT_869089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_uL4_B"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
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    </dbReference>
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        <property type="entry name" value="Ribosomal protein L4"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="294" mass="32319" checksum="A28072A57851ECA3" modified="2019-07-31" version="1">MLSAIRRALGQTPQLARRHLSTAVPSAAHSTAAEHLANQGLRETAHASSSLLAPNASGVSPVSFAGVRPLYLSMSSLIRPEENVDPSDELVELDPDVFAHPIRRDILHLCVVHYLDCQRQGSASTKTRGEVRGSGRKIRPQKGSGRARLGDGQSPMLRGGGVAFGPKPRDFATKLNRKVIAMGMRVALSARVKENSLGVVRSLEWPGTKTRELDQRIQELGWRRTLFVTGHEEIPDGLWRAGANLTGVDMVTAEDLDVYHTLKWPRLVLDLEAVEWFEQALGRPKGVAHREYKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9P6</accession>
    <name>A0A4Q9Q9P6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_841041</name>
    </gene>
    <organism evidence="7 8">
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q9P6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Transmembrane protein 115"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013861">
        <property type="entry name" value="TMEM115/Pdh1/Rbl19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377">
        <property type="entry name" value="PLACENTAL PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13377:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
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        </location>
    </feature>
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        <location>
            <begin position="294"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
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        <location>
            <begin position="329"/>
            <end position="341"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="349" mass="38377" checksum="3690E14025BF4606" modified="2019-07-31" version="1">MAVLSLAPLQFVASIPPTTRAVTAATIVLSLLYYFLLWTGDETFSAPYLVLVPGSSIFYPWTFLTSAFVESTIFELIFSLIVIPASLRYLERLWGSIETAKFVVVTIVASNIIAFVANWLEYLLFRAPVFLYGHQYHGLMALQIGVLVGFTQIIPEHQVQVMGFIKARVKTLPMAYVTFSTVMCIIGFQVPFIIIQFGWLVSYIWLRFYKKNNVETLSGGPVYGDRSETFAFVNWFPPFIHVPITILSNTAYTVANKFHLIPTGGSDVEAGGYSQLPGGARAEAERRRAMALKALDQRVASASPTPQRASNGSAAPPRPGPSTAAPPVVSSTSNDEPSTDITENKSESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA79</accession>
    <name>A0A4Q9QA79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_944498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fl(2)d family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA79"/>
    <dbReference type="STRING" id="114155.A0A4Q9QA79"/>
    <dbReference type="OMA" id="VTQLRQY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033757">
        <property type="entry name" value="WTAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17098">
        <property type="entry name" value="Wtap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="336" mass="37054" checksum="F53F3649046193B3" modified="2019-07-31" version="1">MLLRQRDGQVAELTDEVTHLRQFLANQPPPSTTEPTTIPPSFMSLLLPHLTQRGTAATSGSASVTTALIQRAKILQEENDELYELLKTGETGRLKEDVRSLRRVVQKLEGALRESHQVIASLSAELEKSQDALLQSHGRQLHPGHQPSPAPRGHQLPPHLSNGAAKLPPTGPRAHKKPRLSESQMSPPASTAPLPPKPHLSAANATQPRGGSRDSRASVDRKPAEGSGSMDVDEDSRSGPRSPLRERDRPPHRDRDRERERDRDRDRDRPRNRDRERDRERDRGDHDRSSRRNGGGGGGGGRRGGGRRTNGTNANTNNIDSFANGRDRTLAERMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAG7</accession>
    <name>A0A4Q9QAG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_868592</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAG7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAG7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="19"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="364"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="199"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU63644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="521" mass="56969" checksum="71C892927B9042E8" modified="2019-07-31" version="1">MQIAFPSVKQPTPVQRRLIHAVLSGKDVLLKDKTGSGKSFALLIALLSQMRGSTHNERSGTGAKASSIKSLLLVPHRDLAYQFFYWIECIHRFMTLKQPLASIAQILVRDSSAPLREHLAPIQQTPPQIVIGTPQAVLEAVEADPHALPLDGLSTVVVDEADYLIESVPTLRDKYAMKKMAKKIERHPGPTRLLLNHIYGAPSEDSEGRPRTREKQIDRRRSQTTRKAPQLVMMSATLRNHLRRFLLADSGWFTKGHGTLVKITGDPSAYYPKEVEDSAIEDKAESTVGGTDVKHHVLVIDSSGHAHNIEGAVSASPEQASTALFKEPLKQSQTPETPEDIALREALDEGGILDASNYYALEAVAVAFGVDVPKLALLVLPSNAPVQQRVDVLRAFGINAHPLDVIKDGNGRSHLMQQNFDATDENPTLLVSTLASTRGLDLPQLSHVFILGILDGGVDSYLHVAGRVGRFGRGGKVISVLSERHEVVAKDGKVSARDEPRMMAAMLERMGITAVKYEDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBI3</accession>
    <name>A0A4Q9QBI3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_913935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBI3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBI3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18663" checksum="08E0EADD65366B22" modified="2019-07-31" version="1">MRYRRVAMRADYHPFLFTLMTLTAAAELGLTAFLISAGNEARTWSSPGYHSLLILMCFSSAWTLLFSTAYVLWIVDGAVHILAQVASSVIWLLLTSILWGLGAGFMHNARTGGNCAGHAPISRCRQTLTVEALGWTEFSLCCVTLIATLLWMRSGLGKKKLTRDSRTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD13</accession>
    <name>A0A4Q9QD13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_911643</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD13"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020578160" evidence="10">
        <location>
            <begin position="19"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="12">
        <location>
            <begin position="308"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="562"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="606"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="607"/>
            <end position="608"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU65589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="627" mass="67893" checksum="083D693B4C21E697" modified="2019-07-31" version="1">MFWLIALATQVLCTVVYASSASSGSHRTFDYVVVGGGTAGLVVAARLSEDPHTTVAVIEAGTHHVNEPLVDTPEFFGQAIGNPNFDWKFTSVPQSALNGNVVAQPRGKMLGGSSGLNFMAWDRASATEYDAWEKLGAEGWNWNSLLPYFRKTETISAPTPEQYFPDGPQVSNKTFYTFHGRDGPVQPSYNVLYTNITDPFVEAVNKLGIPTNSDPYEGNATGIFNLEMAVDRVKNVGKRSYAASTYYNISSDRPNLTVYLTTQATKVNIVSGASSQDLRAVSVDVVALNSTGTNGTVYARKEVVLSAGAFQTPHLLELSGIGNKSILENAGIKTLIDLPGVGENLQDHTLLTQDFEIINTTFTYDILRNDQTYLAEQQAEYAENGTGIFASAQFALVFPPLKTIVSDAVLSNLQGQAEELIRASGLPALTKAQYEIQQGWLDTADVGHVEYIMFPGGGVTAASPTPGATYLTVYMGNMHPFSRGTVHLNFTNPLTPPAIDPKYVDKNIDLQVVLEGTKFVRQIAQTQPLASLIVNAHEPSSNVTTDDEWLDYIKTFMGTVYHPVGTAAMVSRERGGVVDPKTLKVYGTSNLRVVDASVIPMLIAAHPQSTVYAIAERASDIIRGLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD89</accession>
    <name>A0A4Q9QD89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_913126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD89"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7434" checksum="3F470CA0CEB00AEE" modified="2019-07-31" version="1">MPLFLFHPTRPPDSSSNRGRGIRARRFPPAFDLTFTSLITTTCSGIFTADSWSARTDHLTYTPSRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDZ9</accession>
    <name>A0A4Q9QDZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_943526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDZ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDZ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU66053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="375" mass="40319" checksum="3817EE2979C4EF4B" modified="2019-07-31" version="1">MAYTDKLWQETPLIRSIHISSLLGCDAYLKLENLHPSQSFKYRGISHFAQHAYRTHGPDTHLIIASGGNAGLAAACAANVLRLRCTVFLPHGGLSQPTIDFIRKEGAEVEIGGDYYLQALQRAQAAVAAEAKAVMIPAYDDPLIWEGHASMVHEIHSQLPEGVRPDAIFCSVGGGGLAGGVIEGCSAVGWDDVPLVTVETHGSNCFYQSLSLNEGPFSGDVSSRLTPEGTRAEYCREHNVTLAHLANLTSRASSLNASSPSATIVKKALERRGGIKSVCLPDEMAMQAALYFAEDHKILAELACATTLAPAYKPTLFRKLVPESEKRTTVVFIVCGGFKISLADLEGYKNIVASEIAAAKEWDVAHNGETFSVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K0C5</accession>
    <name>A0A4V2K0C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_829509</name>
        <name evidence="1" type="ORF">BD311DRAFT_663452</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143422">
        <property type="protein sequence ID" value="TBU28343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145206">
        <property type="protein sequence ID" value="TBU53715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K0C5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7847" checksum="6FBB3132E5643AC6" modified="2019-07-31" version="1">MLAAARRAVQRNLIGVRRRIPKHPADDATKTAAADGDMSVTFILPGETLLFPPGSQRKSLRDIAQPPITSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K598</accession>
    <name>A0A4V2K598_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_977938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K598"/>
    <dbReference type="OMA" id="LWGICMT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU57792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="532" mass="59338" checksum="3DA0141C5550E5B0" modified="2019-07-31" version="1">MTDRDPEKAIPAQSSSSPAASTYSNEKSRISEVERASAKEGDAALHTDVYNAHVDVSGVDEKKLLRKLDWYLVPWLSFLYLLSFLDRTSIGNAKLYHMEADLHITDQQYLIALTIFFFSYAIFEVPSNVFLKRLRPSIWLSLLMFLWGIMMTVQGLVHNYGGLLGMRWLLGMFEAGLFPGVNYYLSCWYKRSEFGIRAALFFSAATVSGAFGGLLAAAISNMDGIAGKPAWAWIFIIEGLVTVVAGAMSFFIIQDFPDTAKFLTEAERTVVVRRLQSDDQFSAAGESLRWHYIWKSVLDYKTWIGMLLYMGADGPLYAFSLFLPSIINQLGFKATPANLLSVPVYAVACILTCVIGFYADKYGNRGYLTMFSLSIGLVGYIILIASRNATLSYVAVYLAACGIYPSIPNIIAWVSNNVEGSYKRSVTIAMVISFGNINGAVSSNVYRARDAPWYRLGHGIVLMYIAIGLVMAIVYHLCLRRENAKRERGERDEIIKGVNDGRTELAKNGTYASVTDAKRDKGDEWSGYRYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5T3</accession>
    <name>A0A4V2K5T3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">STB6-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_849848</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5T3"/>
    <dbReference type="STRING" id="114155.A0A4V2K5T3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038919">
        <property type="entry name" value="STB2/STB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059025">
        <property type="entry name" value="STB6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31011:SF2">
        <property type="entry name" value="PROTEIN STB2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25995">
        <property type="entry name" value="STB6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STB6-like N-terminal" evidence="3">
        <location>
            <begin position="138"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="553"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="744"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="968"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1024"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="878"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1041"/>
            <end position="1053"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1078" mass="118329" checksum="1DF2D087F91DFA73" modified="2019-07-31" version="1">MSSLSSKARASGLSLLPQAPGSPPAPRSKSPTMPSSSTPPSPTSRPPAPRAHTFASSANNSLSVPSTPYHTPHVSSVNVVSTSRRLLMPTVRAVRPTSPRVPNSKPSPSKLGRGRAGSLPVSVVNEPQERTVVGASEWLPGGEKFEVVEEQLELEGFQIYAVEKWVVARKRPVLVLTVFTGDPKHKITVTALSPQPCLSSTEAQAAWDDAIRSLRREGARPKETEKGVLMVTSLANFRSDFTIVHIPSGNFLDVREQLYSNVNLLRMGCGGRSALTLEEPSDATKDRFVAMYHVADKAPARSRELFSATVLELVKLIQASLAIFGMFDLDPEERNGLLCDVTCEGIQRWVTEIGEQYLNIEPTERVAEPTVIAALFSLIVSIRSKLFALGVVVPKDPFLDPIAFVKALTAFYHKSQQSSSHSHLVLPTTPTIASSSIGSSNSGSPVPPLLGPSASPPSVVFLTQSLIETIEAHYEKSRQSESYKVHRVLKNKLDDLATDLRTHGTESGGPTTVTTLSVTTDLAALARCATTSKDAPQSLRYLWTGRAGHAEKKRREKEAVWSDGEREREEKERERDGEKDVLSKDGRDKDERDRDSHREARSGDEWDRPWGGRMQRKIESWAGLGKGKKLSVDFGTLGKAFLTDGPRGLSEKSGQSSLVPSVVVSRDPADEEEFLSSGQQSPTSDVPNPLMLGVGSLPSAERSASDVSEYDRRVSEFNHRRPPIKSQSRIVSWSDARTARGLLHDHSSSSAKVRHHVGASPLGRADSSPGEDNNADMDDLDDMEKELRRRRVLAVGPYRRRSFDDALDLADTRILPVERMRIDVELCGQLLVMRRREAHLANVVACLQALASKLAAQNAKLHADHEGARGKLAELDARAGELQRLEALRTEAEALTQETNALAYESAQFLVEDLWHMAVQPRQRVLALREKVFGTGRRLPQGVRGAHGPFNRVQWRLDGEQRLVDRLGRTENEAEEEEEFPVLPGMDMESEEEGDAVEHPSLKPTWLLRFFNYWGGRLGLSRTQEPPVVQSGTKENGQEQGGEQSQSQENGNGIKQESGESSALAQPALVQRTPTSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6G7</accession>
    <name>A0A4V2K6G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_259465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145265">
        <property type="protein sequence ID" value="TBU52123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6G7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17566" checksum="FAA6578A8E760015" modified="2019-07-31" version="1">MSPHASTALAPRSVEVNDFALTVSLYFASSGSQSSIQLLVASLSFGILTALVTVAIIFLVRQGLRSRISVAFLFLSTLLLYSSTSIYMCALVWYRLRVSQLVLDATNGLTSTAYDASGDVASFEHVVEIQSWMMTMTTGTNVSTLLCSPILFLIPTCPPPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K701</accession>
    <name>A0A4V2K701_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_936347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11879" checksum="C8C46CD6AD9951E5" modified="2019-07-31" version="1">MSRDVDGHLGRGRARSCFDVAAQGHRQARDSGLEVLCGATSSNRCTLLHYMGAPVEQVDDYTTLIIVHGYVWYSGESHLSIIPLSCWPEPQRSRNRFSSTRLSVALT</sequence>
</entry>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU55178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K796"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="TBU55178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14377" checksum="6C9EEB0808A6A683" modified="2019-07-31" version="1">MDICCLTLSYTVVSFNRACPSRSPCHTIFLQTWTRCSSTRASCLSICSPFRLSLSQRSFRLASFPFTLCRAVATAVPPAGPEYIPRNSAGNLSPSVTCPLCRTSRIARGCLLHREVVDGSLRVMYQCGATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K888</accession>
    <name>A0A4V2K888_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_925902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU59008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="268" mass="29745" checksum="DD605F1F11AE1770" modified="2019-07-31" version="1">MSPHGQPQPSANTRRTYMRTTPPTASPSRPTRVTASSLGLASDMSTYNRRDVQAQPLLAHAECRPISPYFRFCPADLAAIIGAIAFILYIVWGINLTIRLYKYLRGSMTTWRRRRIVVPEDLERNFPCNSQHEANASSASTLCEIYCSNGPKYNETPSYPLDHKIKFALDQTRRTSLRFPDSHRSSSAPGDSVNLDSYSPPSTPGLLNFDESTFSSRSSLMTPPGLDDCDCDCDPDIAANSQILNSPPPAYMDHPFGRSKLVCKPCMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K932</accession>
    <name>A0A4V2K932_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="4" type="ORF">BD310DRAFT_919268</name>
    </gene>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4V2K932"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
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        <location>
            <begin position="174"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="38927" checksum="7A5F359F585BBBED" modified="2019-07-31" version="1">MASDPSQPPVSSETLLRIGPILIGALLSWMLFGISIVQLYIYHVSFPCERWAIWASVYIIFALDIFQSIVVANEAWETLCSGWGRPINLQFPGWTFTALPIVSSIISVWVQAFYAWRIHQLGKWRVVPVIIIITSLAQAGGACAIAISFIWLKNIERLHDTNMFARTIVWLGGSAFTDVTIMTSMCYLLYRVKRQSMAFERSEFVVRRLIKLTVETGCACALSAVLELAFFLGMPETNIHLIVALILSKVYSNTLMTSLNSRANISGNKSQYSTSTTMGFRNVGTFADADDTSRGVAISISRVTDSGTAASGTATDDKFSRSWDVEMNDVPPPSKDDRLAPSLGDTTWHKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9A5</accession>
    <name>A0A4V2K9A5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_619443</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9A5"/>
    <dbReference type="STRING" id="114155.A0A4V2K9A5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01011">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="242" mass="25923" checksum="37BB45A3B0E4FB28" modified="2019-07-31" version="1">MSHSADTTDGRASPFRPALLVVDMQEDFCPPEGALAVEGGRDIVPLINDLLQLPFVLKVATKDHHPPDHVSFASNHPGAQPFVSTTTIVNPANPRETYETRLWPAHCVVGTPGNALVPELDAARVGHVVLKGREPRVEMYSAFRSPLRDPPLASAVSDLAEQLAAARATDVFVVGLAGDYCVKNTALDSARLGWRTYVVEEGTRCVGGDRAWAETVAEMRAEGVEVVHADGPEVESVKALSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9M5</accession>
    <name>A0A4V2K9M5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_914714</name>
        <name evidence="8" type="ORF">BD311DRAFT_752017</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9M5"/>
    <dbReference type="STRING" id="114155.A0A4V2K9M5"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU31568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="260" mass="29379" checksum="078CDA26702B3FA6" modified="2019-07-31" version="1">MPQNEYIEEHIKRHGRRLDYFERKRKREARSVHRASATAQKAFGLKAKILHAKRHAEKVQMKKTLKAHDERNVKQKDSSSAPEGALPTYLLDREGQKDAKALSTAIKEKRKDKAAKYAVPLPKVRGIAEDEAFKVMRTGKSKKKAWKRMVTKATFVGEGFTRKPVKMERFIRPMALRYKKANVTHPDLKATFQLQILGVKKNPQSPMYTQLGVLTKGTIIEVNVSELGMVTAGGKVVFGKYAQITNNPENDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9T3</accession>
    <name>A0A4V2K9T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_300171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9T3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19234" checksum="20FA81F450D7B8AA" modified="2019-07-31" version="1">MYVSLVAAVAGESGGRNGHGRDRWSGVVFSVAGIHLLARWHGQPQPRNIRPVTRPRAGRSSPTTGTVVFDRLRHTRTERRSTPCRQLDKTALGTRSARQNACGQISLVADCTKSTLTSDSGSASGPAPIRRQPRCSRALIRRERRVLGAAMTYERELHSRARCTGQSNNPLPSSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWQ4</accession>
    <name>A0A4V6MWQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1040872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWQ4"/>
    <dbReference type="STRING" id="114155.A0A4V6MWQ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="445" mass="50104" checksum="43E1E4DA6438401E" modified="2019-07-31" version="1">MSTASPSAFSLWSILAILFLVFLVHHLWCYDRFKCLRWSAGRQPGAFKRIMTYSYLGAVPLLLVYSIGMTVIKVREGYVLAPDGTFIPMPINAYRDGNRSWVLPLQFVFSFAWALEMVTHLEELAFWLYLLHQNPNKEAWFSSWEYRFWYIGSICAIVGMPLTALITRNNLETCDAYIFLVGSAGSTSTTVMFLYVLWRFPMFIKHVKGEGADPSVVVRLATFYQLNQVRVVFRFLFTIPLLILALDGIIGTQHPIDRDLFVTDFLQMLAGLGCFVSSMITLLIFFPRSIVRESGYKPKVSSTILHSAKSSPVTPPSRSGPFAAEVPAHINLHHLPAHMVGYASPSAFRTSVTGVTGMTGYTTTGYADSAHTQSVYSPRESLQDSRQYAQYSPPRPGEEGADVQRWGTRVSRSSRRGVSRRASVYSGWVAEREWEGEAEGVKTRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MJX5</accession>
    <name>A0A4Q9MJX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_829732</name>
        <name evidence="10" type="ORF">BD311DRAFT_667952</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143448">
        <property type="protein sequence ID" value="TBU26256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145209">
        <property type="protein sequence ID" value="TBU53611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MJX5"/>
    <dbReference type="OMA" id="TRCVKRN"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000002">
        <property type="entry name" value="Zn cluster transcription factor Rds2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053045">
        <property type="entry name" value="Zinc_cluster_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31986:SF7">
        <property type="entry name" value="REGULATOR OF DRUG SENSITIVITY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU26256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU53611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="465" mass="51869" checksum="36B88E80A7B82351" modified="2019-07-31" version="1">MGNSTSGEHDTDNDGSGKKKKGTKRRKVNHACLYCRRSHMTCDEGRPCQRCIKREIGHLCHDERRTAAREKASARRKSTSWRVYSAPPRPPVETLTLRVFPRTTSTAGQYGSPSVSMNTTWPGIGMGMVGAWSYTPENLSNEFSVLSDFLESLDDGTFFSQPPAVAPQLMSSPTYANPVALGVDNPYISQPANIPVTASAPVPAGEPQPASPDRERDKPEEPAPVVLPAATKTERFFLTAADQASGSRNERLNMVIRSKYEAGLLKPYNYVKGYARLSRWMDRNVSQESKQKILHPLSVLRPKFRSIAQSESLTDIDLVFIEEAFERLLLDYDRVFSAMAIPACLWRRTGEIYKANREFAELVGVDGYMLRDGRLCIYELMAEDSAVNYWEKYGNVAFDSTQKAVLTSCVLRYKPLLPSSGATTPARGKEQPPNEEGFISCCFSFTIRRDPYGIPTLIVGNFIKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MKR3</accession>
    <name>A0A4Q9MKR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alpha-L RNA-binding motif-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_821953</name>
        <name evidence="9" type="ORF">BD311DRAFT_722954</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143424">
        <property type="protein sequence ID" value="TBU28190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MKR3"/>
    <dbReference type="STRING" id="114155.A0A4Q9MKR3"/>
    <dbReference type="OMA" id="GDMFQVE"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="136"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="198"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU28190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU57297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="38100" checksum="BFF1BCD2E93F7E18" modified="2019-07-31" version="1">MRDAHIYNFKRGLPRMSWHPHNLYNLWRRSYGPLEKITNRVEYKESLNWRRWTAKALLRAYHGDFINEKIFKRWYLPETLPDVRPTEALKKVEPVLEVNRWANKQEAAQKMEKRAEEERQKGLAPVGSLMFTEVERRIDVVIFRACFAHSVYEARRLVIHGDVLLNGKKHTNPNTRLAPGDMVSVDPKAIRFLQDRPDPVEEDADTAEEAADAAGEASESKSESKTVPSTSRFSKKHSTSSSSNTGLTPFNLPPYASPFLFIPAYLEPSFATCSVIYLRHPTARPGYSEVPTPWDADGEVVRLTWEWYSKRRMRIRSKSQLARMPDNRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MV48</accession>
    <name>A0A4Q9MV48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_815243</name>
        <name evidence="15" type="ORF">BD311DRAFT_658870</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MV48"/>
    <dbReference type="STRING" id="114155.A0A4Q9MV48"/>
    <dbReference type="OMA" id="QVYRDWW"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21386">
        <property type="entry name" value="GAT_Hse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="14">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="287"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="192"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="207"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU30512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU60532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="449" mass="49284" checksum="E1BB9D9B585EF4EE" modified="2019-07-31" version="1">MFRGGQPNPYDDIVAKTTDENLTGENWELILNLCDKVQEEGEQGARNVIAASLKRLAHRNPNVQLYTLTLVEALSKNCGVEVHREIASRAFTQGLEKLVTDRTTHDRVRKRILNLVAIWTAEFEKDPALGLMEECHESLKSKGFKFETPNEPPPPDVDDEVRRREEEELQRVLELSMLDKGGRSQWNSYSLASSTGASGSGVGGSRQGLPSSSATSGPSSSSSGPAGAPSSQSSQPPSYGGYVPSSATPAVASVQPHQSPSTVSTVSSVTVTSSSPVSVHSNQDSIPIVTRVRALHTFEPSEPGELAFEKGDIIKVVDRNYKDWWRGQLKGRTGIFPVNYVEPLPEPTAAEIAREAEQEAAVFAQAANVDRLLLMLRTMDPAKDNLADNEEIQELYRSCMTLRPKIVKLIDKYSQKRADLVSMNESFVKARSIFDRMMEESLARHTGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MYX4</accession>
    <name>A0A4Q9MYX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_918092</name>
        <name evidence="13" type="ORF">BD311DRAFT_712349</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MYX4"/>
    <dbReference type="STRING" id="114155.A0A4Q9MYX4"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000067">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000007">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000039">
        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="227"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU62734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="449" mass="50135" checksum="16460CA347721AD7" modified="2019-07-31" version="1">MGNAPSGLPGQRPGGRGQPGDQKDKKEQKKKWEPPLPTSVGKRKKKRGPDAASKLPAVFPTTRCRLKLLKMERIKDYLLMEEEFIQNQERLKPESAREEKNEEDRTKVDDLRGSPMAVGTLEEIIDDDHAIISTASGPEFYVSIMTFVDKDLLEPGCQVLLHHKNQAVVGVLQDDADPMVSVMKLDKAPTESYADIGGLEQQIQEIKESVELPLTHPELYEEMGIKPPKGVILYGVPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSTSGGEREIQRTMLELLNQLDGFDTRGDVKVIMATNKIESLDPALIRPGRIDRKIEFPLPDIKTKRHIFKLHTSRMSLAEDVDLEEFVTAKDDLSGADIKAVCTEAGLLALRERRMRVTKVDFTAAREKVLYRKNEGTPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N087</accession>
    <name>A0A4Q9N087_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_882658</name>
        <name evidence="10" type="ORF">BD311DRAFT_711942</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N087"/>
    <dbReference type="STRING" id="114155.A0A4Q9N087"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="141"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="444"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="470"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU33819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU56361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="560" mass="62735" checksum="1A2D6C7DCAF89143" modified="2019-07-31" version="1">MASASATGKLSREEFRRQKDLDAARKAGTAPAALDEEGKAINPHIPQYIAQVPWYLDTGKPTLSHQRMPDYDRSADKLDNWYDRGAKAGPAAKKYRKGACENCGAMTHKRQDCLERPRKKGAKFTNRDIAPDEVIQDVASGYDAKRDRWNGYDPAEHKRVYDEYAAVDAARQKLREEEIDKRTTTDLAAVRKVAKAGKEKAEGKDDDFGSSEDEDEDQDKYAESADAVGQKLDTKTRITVRNLRIREDTAKYLINLDPSSAYYDPKTRSMRENPNKGVPPEESKFAGENFLRSSGEAPEVQKLQLFAWNAAARGNDVHVNALPTQGQLLHLQYVKKKEELKDTTKVSILAKYGGEEYLQKAPKELLQGQTEEYVEYSRTGQVIKGKERAKTRSKYPEDVYVNNHTAVWGSWYDVATGIWGYACCHSSIHMSYCTGEAGIEAAHASSAQQLLESAPPSSSMPPPPVPSSSVDERKKKAEELFSKKRLGEGDLSLDHDKLSKALSEERKRKARGDDDDDRGGKKPKGGLGKSYEVSEEELEAYRMNRRMTEDPMANYVDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N313</accession>
    <name>A0A4Q9N313_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MSF1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1034462</name>
        <name evidence="3" type="ORF">BD311DRAFT_708862</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N313"/>
    <dbReference type="STRING" id="114155.A0A4Q9N313"/>
    <dbReference type="OMA" id="GYEFFKC"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU34934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="26262" checksum="10071B06D6AD5420" modified="2019-07-31" version="1">MKFYSQSFLYDDPWSIVSLAYLLRYPNPYANHILSCDVISREVTPEGSLRTTRLILKKGSLPRWAPAGMIQRAESWVLEESEVDPLGKNMRCTTKNLDHVKVMRVEEHIHIRQAEDGKTLQTTEAMFLSGFGWGLTKKIENYGLAKFKANLQRSREGFFVILDLIRQSRMQPMTMGAPSSFLSHRSIAGPDAKPPAHHEVPAKGDSREDGASSPAPARRGYWARWKTWLGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N8L9</accession>
    <name>A0A4Q9N8L9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_911568</name>
        <name evidence="5" type="ORF">BD311DRAFT_744459</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N8L9"/>
    <dbReference type="STRING" id="114155.A0A4Q9N8L9"/>
    <dbReference type="OMA" id="FYKDAQH"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000020">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU35712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16881" checksum="FB6F4B5920C87BE9" modified="2019-07-31" version="1">MSLQTLWRCADVLRNPFRAAGLGSVRTATKRAGGTVSNHGGSPGKRLGVKKFSDEYVIPGNILVRQRGTVFHPGQHVKMGRDHTLYATVPGFVRFYKVPGTRKDRKFVGIVLERGEKLPRDETNRGRSRYFGLVDLNALDKESPSQATATALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9Q5</accession>
    <name>A0A4Q9N9Q5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_766428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145255">
        <property type="protein sequence ID" value="TBU52349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9Q5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="7104" checksum="69CE564472D7839A" modified="2019-07-31" version="1" fragment="single">VFFYDSIITTAEEIRCFWGRKITGAAILFWLNKYMSILCLVWTFATFLNISDKVRIPPLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAZ5</accession>
    <name>A0A4Q9NAZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_931652</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAZ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NAZ5"/>
    <dbReference type="OMA" id="SWRLDRE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="543" mass="60982" checksum="BB974D4C42F19378" modified="2019-07-31" version="1">MEQLVQLAVVFAVLGLLRALYRLLVRPSIADIPGPEPTSFLLGNLPELFQEESGEKDFEWQEQYGSIVRVKAPFGEDMLWISDPKALQYIYQTSGYNFPKQPERRILSRLVGDPGLTWAEGDVHKRQRKVMLPAFGSPESKALLPVFRHYAEQVTLKWKDLLTGNAEGSIKMNVHDFIAPATLEAIGEAAFDYKLGVLGDDASELGKAYSNLIATIFSAPSSAKIFLQNVAHYVPMWIQEYVYDHLPGKGLDKARENRVAAHKVAHQLLEEKRSALAIGKAARDVMSILVRENAQESGESRLSHEEIIAQMRTIMLAGQETTSNTLSWALLELATQPNIQRRLREEVHAMEHTIRERGDADFTVADFEAMPYLQAVLKEILRFYPAVPHTFRQSLRDDVLPLSKPVTTRSGKVITELPIRAGLRLILSVCAYNREKEVWGEDAQTFNPDRWLTSGGKRSSSVGVYSNLLTFAGGVRACIGWRFAIYELQAFLVELVSNFQFDLTEDVDRICKTTAIVMVPTLRGELAKGVQMPLRVSLAPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NC46</accession>
    <name>A0A4Q9NC46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidase C14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_835054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145370">
        <property type="protein sequence ID" value="TBU51176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NC46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU51176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="338" mass="36879" checksum="0C36688DDF3E1E3D" modified="2019-07-31" version="1">MPVTSRRIVKEALLVGVSYATNDNLKDNDFPPQPGAHKDTLALRRLLTSKYGYEEKDITTLVDSDEVPHESWPTKENILRAMKDLIADKQAGDHIVFAFSGHGGQVKALVESEEIDGMDEILLPVDCTVDPTSLDNYFVNFIRDDEIRDIFVNQLDAGVRCTLIFDCCHSGTASDLPSVESPIATTPGSPLFGSISPRSTGARAPGSFAQLETLHDGHANGADSAPYLWPGARAASISYFEKAVTSWSACLDDQLTFGRKSGGIFVKAFTHALELNPTPTHGELLQSLRTSLIKVIEDVNRRHVVSSRGDTLWSACVPPRPQLGSLCPKTILQTQFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDD4</accession>
    <name>A0A4Q9NDD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_980530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDD4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NDD4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001148">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="724"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="733"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU54210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="754" mass="84656" checksum="6409CA3DAFDE7AB3" modified="2019-07-31" version="1">MGVDNPYTNAPPIGANPLHGFLPRKVTAEQVIRAMESDVNPFNKQPHKPQYKKILEGRKKLPVFGQMAEFLKIFTENQIIVMVGETGSGKTTQIPQFVCYSDLPHTKGQMVACTQPRRVAAMSVAKRVADEMDVSLGKEVGYSIRFEDMTEPGTTFLKYMTDGMLLREAMNDPDLKRYSTIILDEAHERTLATDILMGLLKDLARRRSDLKLVVMSATLDAQKFQKYFSIAGPSKPAPLFKVPGRTHPVEVFYTQEPEPDYVEAAIRTVLMIHRAEEPGDILLFLTGEEEIEDACRKIKLEADDLVNQDPESVGPLVCVPLYSSLPPQQQQRIFDPAPPSRVSNGPPGRKVVVSTNIAETSLTIDGIVYVVDPGFSKQKVYNPRIRVESLLVSPISKASAQQRAGRAGRTRPGKCFRLYTEKDFMTELEEQTHPEILRSNLANAVLELAKLGVKDLVHFDYVDAPAPETLMRALELLNYLAALDDEGNLTPLGAIMADFPLDPQMAKMLIVSPEFNCSNEILTIVAMLSVPNVWLRPPNQRKEADAAKALLTIPDGDHLTLMNVYNSYMNNKHDRNWCWNNYLSGRALQQAENVRSQLQRTMERYEVELVTTQDERKLWQSIRKALVCGFFMQVAHKEGEKGGYLTVKDNQIVSLHPSCGLDSSPEWVIFNEFVLTTKPYIRTVTEVRPEWLLEYAPNYFDLSTFPEGETKRALQRVLKKRSLKAVDGNGTGSPSNRSNSPASSEPAKKKSKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDN7</accession>
    <name>A0A4Q9NDN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_951166</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDN7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="235" mass="25660" checksum="1BAD5F0FA4C8D0C2" modified="2019-07-31" version="1">MPLCWKKTAPPSGSQYPAERILVLPLDVTQPHQVADAFAKAKERSGRMDIVVNNAGIADIGKLEGMEDSKARGLLETNFWGAVSVTKEALKCFRETNPRGIGGRLLKISSYLGLVGLPALPFYCAAKFALEGATEALAAELDSDWNIKATWSPEHPAYSNPALPASHARKVGWDNVVAWKDMRRSAELFYKIASDPNPPLHFVVGKDAIEATRKKITALAADIDLYEAWSNGLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKZ4</accession>
    <name>A0A4Q9NKZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_815440</name>
        <name evidence="3" type="ORF">BD311DRAFT_676255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143544">
        <property type="protein sequence ID" value="TBU22395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKZ4"/>
    <dbReference type="OrthoDB" id="2803471at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU22395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24370" checksum="3E2C011F37DF60DD" modified="2019-07-31" version="1">MSSCLATELMIAMGKTRVENEYHVFAGAVLIYYDWLLVFDREIRYVWPRPLSSSSVLYIIMRYLSIFQMLLTILDLSSISEESAKVSVLGYLSVISGTVMIITTVAVFAGLRAHALSPSKLWAAILVALLGMVNPMTTLYLSLTGGGWTNLTPSGHYSVSKAPIGSYFGFDIAMRTCALAADAIVLVLTWMRFWPQKGEGMRFGHLSMLPAVLFFGGTCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRZ2</accession>
    <name>A0A4Q9NRZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_851067</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRZ2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NRZ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="592" mass="65886" checksum="62E7CEA77C3CB960" modified="2019-07-31" version="1">MTLVVWIGTLLGAFVLWQLVGRRSAPNGLATVAGPQRERWLTGNFHRLFKDGLEYNLGLIRQYGGVVKVYGPLGAQQLLVSDPRALHHVVVKDQDVYHETDMFLMTNHLIFGEGLIATVGEQHKKQRKMLNPVFSLANMRAVLPTVAPIANKLLERIQAQLSEGGGTAEIDVLPWAGRVTMDLLGGAVLGISLDALDPEKTKEHALTIRKVSRAALKVLVLRPFIPMAVRNFSLYWRNKMVDWLPWPALREMRELSRTLDRCARNVFHEKKDELENGITNDYDGPRRSLMTIMLEANQSGSEKERLTDEELIGQINTLLIGGDTVTTAVARVFWILAREQGAQARLRSEIKKAKMAIAVDDGVEDEWEKVPLSYDTLVSLPYLDAVVRETLRLYPPTSLINRVATKDAVLPLQDPIRTTAGEETTAVHVPAGTNIIISILGSNHNKRIWGDDADQWRPERWLTASGERIGWGKNVDLAFDDDAEGHVAEGTPGYRNGVKYPGVYATMMTFLGGSRACIGFKFAEMELKQVLATLISSLHFSLPSATNEDGVRKEIYWRMDGLQVPVVLPPHGDGKSPSVPLDVRAARETDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUD7</accession>
    <name>A0A4Q9NUD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_911398</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUD7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NUD7"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.960:FF:000005">
        <property type="entry name" value="6,7-dimethyl-8-ribityllumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU65471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="210" mass="21994" checksum="503A3ECE8BEE98BE" modified="2019-07-31" version="1">MSESIKGPAPPSTKLDGSPLRIAIVHSRWNETVIDALVAGTIAKLKATGVKDSNILVQSVPGSFELPLACQKVISGSHVQAGATATDLLGGLTSFTSPNPTSRSGTPAPVSASMPHQPFDAVIAIGVLIKGSTMHFEYICESVSHALMRVQLDTGVPVIFGVLTALTDDQALERAGIGRGHNKGHNHGEDWAAAAVEMASHTRRWAEGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV20</accession>
    <name>A0A4Q9NV20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_807627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV20"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF74">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="395"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="547" mass="59451" checksum="09D2F2AEEBB8451B" modified="2019-07-31" version="1">MGTFVDRLRPKSFTPRYPRWMVGRPLLIGSSALASLGDAMFGYSQGVIAALQVQPPFIRRFFGRNVTMEQITTGDTGVDPYVQAITVACLNITAFFAALGAAYICDILGRRMSVRIGGLVYLVAAIIQIVSPDLACLIVGRSLQGIGVGILSMTVPILQCEIAPGHARGLFISIEYICLNAGYALSSWIGFAFFFTLPSEISWKGPYIIQAFLALLLVLWSFILPETPRFLIKNGFLDEGLRILADLHANGDIDDPHVRATHAEIRATIQLEEALGQASWKQVFLQYKRRTVMGITCQLFAQFNGINAILYYLPTNLLRAGFSIEQSLLYAAGSSLVYCAGTVPAMFGIDKLGRRPFLLVGSVGLAAALSIVGGLQFYVDSLPSGNARLPGADGIYAGVCLYLFFYGATWGPGPWLLGAEIFPMRARAKGMALSTTANWISNFIIAFITPPLFSAIDGGYYFILVGFCVISGVFVFFVYPETAHKTLEELGSVFDDQVSNEEVEKCEQATLHVPETAVRGDSASDQTLRPSVCSSDFKKESSADLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXQ0</accession>
    <name>A0A4Q9NXQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_931831</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXQ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU56300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8668" checksum="143291BC1FC7CA2B" modified="2019-07-31" version="1">MSKFADPLCQQEACSLQACLKKNTYSPEKCDDYVRKLYRCCWAMYQQTDGKGESTACPLPNVTRRWLENHGESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZY7</accession>
    <name>A0A4Q9NZY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_842222</name>
        <name evidence="6" type="ORF">BD311DRAFT_676431</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143548">
        <property type="protein sequence ID" value="TBU22296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZY7"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU22296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="295" mass="31881" checksum="EEAAA3F503C006F9" modified="2019-07-31" version="1">MASENSKFAAPHLFNVEGWVTVVTGGGTGIGLMIAQAFANNGARVYITGRRKEVLETAAKTWGKSLLHPRGQIIPIQADCTDKDSIHNLVNEISKNEKHVDVLVNNAGISKGTSSVEKGDESAQALKEQLWNESLSDWEEVYRTNVIGYFFTSAAFVPLLSAAQRQDHTGTVINISSISGITRTTQHHFKYNVSKGATIHLSTLLAQEFRRPGVKVRVNSIAPGIFPSEMTTGDSDETNKSGMEVGPDYGETKGIPAGRPGRGEDMAQLALFLACNEYAYGQTVAVDGGYLLEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P003</accession>
    <name>A0A4Q9P003_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADH-quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_916871</name>
        <name evidence="10" type="ORF">BD311DRAFT_749248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P003"/>
    <dbReference type="STRING" id="114155.A0A4Q9P003"/>
    <dbReference type="OrthoDB" id="204405at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849:SF20">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU33117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="249" mass="28017" checksum="0C20479EA2932D88" modified="2019-07-31" version="1">MSFARALVAAGPSARLAAGRVTASRSLALAYRWHSTAPRQQQVDPLVSNKPRDYLNPGPPIRSPGTETATYSATNEPGKDYDPYKDGPSAIDKAVHLFFFTEIIRGMWLVLEQFFRPPYTIMYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIESEARLDGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVETQNQEFSTETREELLYNKEKLLANGDRAEAEIAANLHADHVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P0U1</accession>
    <name>A0A4Q9P0U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_978188</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P0U1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P0U1"/>
    <dbReference type="OMA" id="TNEGRFT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="265" mass="27733" checksum="7B1BC51DD7FF5A88" modified="2019-07-31" version="1">MKLSVLVLFSVLIASATALPQPDKTIAKRATPTLYLAGDSTMAKGGGGNGTEGWGQYLGYSMNIPVVNDAVGGTSARSYTDQGRFQSLVDTVKSGDFVVIEFGHNDGGSLSTTDNGNTDCFGDGNQTCISPTTGETVHTFVYYVEQAGKALQAKGANVIFSSQTPDNPWESGTFEYTPSRFVGYAQEAAGNLSAAYVDHGQYVANRFQSLGLSIVDSFFPMDHLHTSPQGADVVSAAFVKGVLCANDVLAAHVKNTTGSVPGSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P496</accession>
    <name>A0A4Q9P496_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Shr3 amino acid permease chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_921723</name>
        <name evidence="3" type="ORF">BD311DRAFT_754274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143404">
        <property type="protein sequence ID" value="TBU30731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P496"/>
    <dbReference type="STRING" id="114155.A0A4Q9P496"/>
    <dbReference type="OrthoDB" id="5229808at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28228:SF1">
        <property type="entry name" value="SECRETORY COMPONENT PROTEIN SHR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU30731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20485" checksum="E5BE9079C3E54833" modified="2019-07-31" version="1">MGYRQAAVLVSVSFFLGVLAICLNVDYRILFTPLSDSVVRDGFEFYTTFYNSPTAIKALLHGVIFLGLVGLIGKLHKWDDSAVFFDGSSLAAYIFALAVYMTVGIPSCRTVADPVPAVDTQEDRVEALRILSAGNTIIVVLLGGVLVLQAGEQWARRLESNILKEASPADKSKTVPEKPAGETESKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P761</accession>
    <name>A0A4Q9P761_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_917306</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P761"/>
    <dbReference type="STRING" id="114155.A0A4Q9P761"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="776"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="800"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="87"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="540"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="612"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="697"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="543"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="612"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="707"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU62867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="867" mass="98800" checksum="72EA4BAC845D1C9C" modified="2019-07-31" version="1">MKFGRKISNDLYNEWRPFYIDYNGLKRELKDRTISRNWNDQDEAEFTRMLEAELDKIHNFQKTKTYELSRRINDSEKAVKRLVSDVELHNGHHAEPSTATTDSEAQQRREGVTQDAGSDDDDTDDEGDDAMSIDALEDQFALLEEEVATLVADVHDLALYTKLNITGFMKILKKHDKQTNRPLKPTFIQEYLEKRPFYKYNWDSLIVKLSRLYDLVRTRGHPVQGDSSAGGNQSAFVRQTTKYWVHPDNLVHLKLAILKHLPVLVFNPDKEFEPKDAAISSVYFDNEDLELYLGRLEKTEGAEAVRLRWYGDMDQKTIFVERKTHREDWTGEKSVKARFPIKEHLVNAFLRGEYTMDEEFQELVKKGKKTQAEVDSMIQLANEVQYSILTKKLVPVMRTFYNRTAFQLPGDARVRISLDTELTMIREDNWDGRIRSGDNWRRMDIGIDFPFEQLPPEDKELFKYGVLEVKLQTQYGQEPPEWVTDLVSSHLVEAVPKFSKFIHGCATLLPNRVDLVPFWLPQMEVDILKPDTGVVTIERPLHTSSSKGTSSGAGTSGKTTPERMHYTEPVSEGEEEEMDLAPAKDEDKRTGLSNQQVAAAVAIREKNLKERERAQLQQRREDAAHDADADADGKSDAGEETTPFLRRRGRQQEREAATANAIASALDHTAQARAMSIDPLAPSSAFDETLRDRLRDDAQRRRVGGEAVEDEDDDADDEETGAGARAQRARGEGPSTNGEDRLLERSWRAPAGKRIAVPVRIEPKVYFAAERTFFKWLHLGIFIGTIATTLLNFVPPDDAVGLISAWCFTGVALVAILYSAVVFVYRAYHLRERRAEGMYFDMYGPTVLSVLLVAALATNIGLRMREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P979</accession>
    <name>A0A4Q9P979_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145391">
        <property type="protein sequence ID" value="TBU51124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P979"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13050" checksum="B8365739EA2D6996" modified="2019-07-31" version="1">MALGATTLRRVSAAILLAGSGSLPVQIQMTPRTPKTPQALNVLTSFNRLRKLGRKVRLLLGQLSQKLGPLPSWIAPYKEDGRKVRPRKFKSALGEDPHASEEEHALEVEEVEDDKDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9K2</accession>
    <name>A0A4Q9P9K2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_513477</name>
        <name evidence="2" type="ORF">BD311DRAFT_806407</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143415">
        <property type="protein sequence ID" value="TBU29193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9K2"/>
    <dbReference type="OrthoDB" id="2753093at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="465" mass="50775" checksum="41A92E796B66F0E0" modified="2019-07-31" version="1">MVAIHQSEDFVRALSSIIFACVTTGHSTIKLFDPITGALEDYSLLKTSLASESHLDCPAIRHSPLGKTALPPPQVALDDILNLLSAYLGKENVRCSSHGKQASPSSMLLHLQILPPHNSKSRPSGRQPLAPKDPETHRMPTAVESTKDETDVSIYPGPLTQMKRAMFFGEGREDKWRPFTVLPPTLLALCKNSTPPLQDDSRVSSGDTSSSSIQYTPAKALQSQDNFLDASTCLDSSRSPSRLVGLGFSALVKDDGSSFDGLGTLTDRPYDNLPSPSDEARARARERRDRRVFGAVVLMRDDLGAKITPQLLSDMQSPARSQAPPSLDRPFAPSTKISTPVSVNALERVPPAAPAKRLIGRMPLVVDERTKFRRGIGRETRPQHDVFAFQRERVSPEWQMESFQRLGGVAGSARTMRGGVGSSKKFSPSPLAPPSALGNQLRFWSYWMTPVNDASGSMGRPAWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9V6</accession>
    <name>A0A4Q9P9V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nitrate reductase [NADPH]</fullName>
            <ecNumber evidence="7">1.7.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_942175</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Nitrate reductase is a key enzyme involved in the first step of nitrate assimilation in plants, fungi and bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>nitrite + NADP(+) + H2O = nitrate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19061"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mo-molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.3" evidence="7"/>
    <dbReference type="EMBL" id="ML145320">
        <property type="protein sequence ID" value="TBU51449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9V6"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9V6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050464">
        <property type="term" value="F:nitrate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008482">
        <property type="term" value="F:sulfite oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006790">
        <property type="term" value="P:sulfur compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.420.10">
        <property type="entry name" value="Oxidoreductase, molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005066">
        <property type="entry name" value="MoCF_OxRdtse_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008335">
        <property type="entry name" value="Mopterin_OxRdtase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000572">
        <property type="entry name" value="OxRdtase_Mopterin-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036374">
        <property type="entry name" value="OxRdtase_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372:SF7">
        <property type="entry name" value="SULFITE OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19372">
        <property type="entry name" value="SULFITE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03404">
        <property type="entry name" value="Mo-co_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00174">
        <property type="entry name" value="Oxidored_molyb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00406">
        <property type="entry name" value="CYTB5RDTASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00407">
        <property type="entry name" value="EUMOPTERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56524">
        <property type="entry name" value="Oxidoreductase molybdopterin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="14" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="586"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="704"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU51449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="982" mass="111422" checksum="6F5DD241BC3C828C" modified="2019-07-31" version="1">MFAPRDAVPRVDNHWRERLRDLQSGSVVSVRDVKEAEPDYKLNDPLKHDFARYVLPVTESEIKTQMSKCPTVSTNDAAQNVRLPPSDSYSDNDERQAYLDQLRAEFETISGFQSDLGKPSTTELQGPDGDTLEQLESDLSTLDQNYPDSWIPRSSELLRLTGKHPLNAEPNLHALFQAGMIIPAKLHYVRNHGAVPQLNWETHTFVIYVDPSVIDLKLQECTYSMYDLTGEKFNDSVIEIPVTLGCDGNRRKEMNMVKRTKGFGWTASGVSTAVWRGVPLVQVLRDWGLTEIPAGKRWYLNFEGAEMLPEGPYATSIPLEHALNPINDVLLAFGMNGRVLHPDHGYPLRVIIPGYVGGRQVKWLKKIWITAKPNDSYYHLFDNKVVPSFITSTSDPVAQAFFRDESTACWEQTLQSVICEPAHDERLELTDKVRNGEYTVRGLAYNGGGERIERVELSVDGGKTWKYCFRHFTDKPLRHADKWWTWIFWSCDVPIQEIVDGSGDIIVRAHDQKKNFQPENITWTLTGMMNNAWYRVRRTLVKDHRTSTVVMRFQHPVAPGEETTGWMIPPTDEGIDMSVVNKTKKLPTYELDDVQKHDKEDDAWIILDYDKVYDLNRGPNGLSILSQHPGGPRVLLKYAGKATVNASLEYDQIHDNRAHEMRAFCLIGRLSAKGVAKMKEDYKCAREELRRLKEQQRGYALQPDVFIRAMLRERVDETSSVRRYTFEIPSRNGATPAKLGLPVGRHVQIAVHFEDQAVVRSYTPIFPILPEEDTGGTFQLLVKTYFPDKVKANPGGTVSNYLDCLQKGQEIDIRGPMGDITYNISDGVFDVRGQKLRYEKINLLAGGTGITPIWQLIHAVLSTTSTSPQLNLINCNTSGDDILLYADLERHKGDRLKIWNVLSDPSKARHRILDPKDYIVGRVNAEIIWDHFEAPSYMGGHDTVATFVCGPDSLVLQIAAPALTKWRGRPVGFVEWQSLFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAK7</accession>
    <name>A0A4Q9PAK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_834232</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145315">
        <property type="protein sequence ID" value="TBU51488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAK7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="49" mass="5315" checksum="02D0E8DE65408401" modified="2019-07-31" version="1">MPFLPLAVKQLCQKLGRHSMQLFAGQPKAASALFYYGMAHSTLGAVMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBX5</accession>
    <name>A0A4Q9PBX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_940672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBX5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="37707" checksum="853FC68EF6D41C8A" modified="2019-07-31" version="1">MYSDNRPLVLVVGATGRTGWSIAQGLLASGNFRVAALVRRASLYFRSTEALRTSGVEVRVGDVKDSVQTLSLALQGVDTLISAIPRALIPEQKGLLVAARMVGVQRVIPCDWSTPGARGVREVLDQKIAIHEFIQQLELPFTFIDVGWWMQAYLPLPQRSVVPEHCRANTETIVRRGEAKNLVTDYRRIGIYVGRIIADPRTVNRSVIVWEDEVSQRRAHQLAERYSGEADFIRSRRVFVSRDYFLKKAAETRRKIGQDPSKATPADHVTLSFSEDMHSMYVLEENTLENAKRLGYLDVRELYPDLPRYTFKQFAKEFYRLPRPGEDHKSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD26</accession>
    <name>A0A4Q9PD26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_205389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145238">
        <property type="protein sequence ID" value="TBU52744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD26"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9131" checksum="AB7CBF793D4D5F88" modified="2019-07-31" version="1">MVSGRSATALGSAVVILPRLIDVIDCRPPAITYYIRTSCGLYDRGTTLPCSVCIPSSVRLLNMHLVSHSPVYDSAVAPRMLLPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE51</accession>
    <name>A0A4Q9PE51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_830606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145222">
        <property type="protein sequence ID" value="TBU53174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE51"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="288" mass="32514" checksum="50DB993D1E81D4E6" modified="2019-07-31" version="1">MYINSDHCLLGFFKVAHEFTTRLPLCNIPTTTQDLYDSRWVKVGLVNVRNEFETCCMPYLPTWYEGQFGPHLFGDMYVDPKVGVEPHICMGLQDTHDPHSRMFPVNVMLDFLGFFRHYLSKHACLTDREVRGPPLVLIYKVSPRIHDGAGSYVLVQYVEAKFRPQAPGFIAFATKLLTDYLFNAPEDTKMLSIGDLPVRDDAVEYLLDFMLGQQPGACVAVASSEQFYGLFDPDHDEVPPCEAGEVLSALERLQREGKINVTTQDIEIDGQRIQGLRCDPSSPSKDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEJ6</accession>
    <name>A0A4Q9PEJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_830284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEJ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16537" checksum="190A7F424EA8AF08" modified="2019-07-31" version="1">MTTQSFHMTNEGIRRTDGRLRASSFCLQTSAYFWVQDLHSDGNATVSAWNRNQATLPGCPERWPPTSSTIVEPAARSYRKNIHTLNFFLVRSAITAYLASCTSTLVTQRICIANAFMQARLPMGLLPKVPSVSAVDVTIVSFGRLPLSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PES7</accession>
    <name>A0A4Q9PES7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_212235</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145242">
        <property type="protein sequence ID" value="TBU52635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PES7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PES7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="581"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="518"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="907"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="910"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="608"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU52635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1230" mass="136625" checksum="C0F1E6F48B4E4157" modified="2019-07-31" version="1">MSSRARSFPLSKTPPTPSPLSSHLSSDSTAASTVKVPSPLNPAAPSPKPPSQPPADVSFSNPFKSPATTSQSASNQSVRSRGASVSTIRPPAIPLGRVVSNPIPTSSSSSTTTLAPGDSDFRERSRASSVQLRGRSASPFRDLSFIWRSSAHGDEAPTPTHEQSTSWWTTREVVPRPWKQKTVPVEQTDGYIRTRNRVIEAATNVLGTTALVTHELLEVSVDLLRFAPIIGLEEAARSLLSIWDALQLVDINRLACLRLTERCATILMSIREEIANAGDEVGIELQPPLTRLVESFREVHMFLIKTSHRPFIKRYLQRDEIQRALGACHSSLTDALGMFNTSIQIRILKQVVAAERQRQADAAALLDSISHNVQGSQPITIEPSLYPRAISPAPTNRLLLTIEPDTTEGHDDSGHILAQLQAVTARQNERDMVYDTADLRQLMRTALQANNDAEMIRVLQVGRDEMPEAIKTLQRALEKEVERESLEEEAVLVSANVAAVEVAGPQIAQSDTLGLTRSATVHSTGSSGTTSSSVASSAGRSSRAPRDTLDREFIETGIDALRRLSGAEVTLPSWTITRYEVERDEKIGMGFFSDVYRGTWRNHVVAIKVLAPTTPRQLFVHEVSIWKTLQHPNVCELLGASSASSDPPWFFVSPYYKNGSLVTYLKGLPSLDSVDLLKMVHEIAKGMSYLHSQGVLHGDLKASNVLVNDKHHCIISDFGQSEMKSEAYRVSGLPLPHGTLRWQAPELMSAQSGLTQQIDVYAFAITVVELLTKGALPWPMADDDAVRHFVLRENMRPELPLQRVWSQQLSEVLHSCWHRDPTMRPPFLKIDKDVQRLRALHGADLKESPVSRHLGLEQMKARKSPDMHPIPLPLLPDEVTASFVEVGSAPSTDVSFMTAMEVESVTGHSQDYHGDYRDRKDPETDLSRTSSRASVQDSQSSEHIEFPRHVSPPPPDEHAQNIRDERRYRMLLQHEFHPSLTLPLWTPSQILIGAVGYHSKANYGEFVTLFNSFEPEKSSNGRVKNIPSLYGYGRVSQGSQRQDKRNVAQRGMDMIQSWLGPRNRAGEATYSRRYSAPLRSGHKAANLFTESTVYRYMEDLVTPKKWFKANADTILAIYGEENRITKEDLYLVIGTLEAQDYALFVSHEHPDGQVNFNVFSATRNGRPWGEFTFSFDISSSFLGGPKYEEEPVGAPQYARKISTSGNNGRWDSVLLARLRFKPDSTEPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG38</accession>
    <name>A0A4Q9PG38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_940932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145264">
        <property type="protein sequence ID" value="TBU52157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG38"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14133" checksum="DE1366F1DF5B5322" modified="2019-07-31" version="1">MQRWIAQAGSVSIWKIKSCAKISLQTYRVESSYDPTGVIVSLSSTETEGFTIMAMLRRRRNVPTRMPSVVAQRPQCLNLLRLTRREAVCPEDVPPSTRLQAATPHRRLPAVDRAHSPDLAPVCRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG63</accession>
    <name>A0A4Q9PG63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_834475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145330">
        <property type="protein sequence ID" value="TBU51386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG63"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14451" checksum="DD996D5E49F4E4AD" modified="2019-07-31" version="1">MSSNTVGPPVSLLAVPSLDNTFGVILIGTFIGLIMYGLSLYQTFRYFRVYVGDPLILRYTVRCILKCSRYNAFGCLHVYIVYYYVVTNYFNPVALLSGVWSIRVRFGLRMLCSILLKSFLSGASPAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGM5</accession>
    <name>A0A4Q9PGM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145257">
        <property type="protein sequence ID" value="TBU52311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGM5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGM5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="12374" checksum="773451EBD13141A0" modified="2019-07-31" version="1">MVHCYQYNGEGKTPGGLIEGIADWVRLNAGYAPPHWKKDADGDWDGGYQKTAYFLDWIEGRYGDGSIRELNEGMKDAEYDEHIFKDVTGRKVSKLWTLYKEHLEENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHW8</accession>
    <name>A0A4Q9PHW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_938042</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145214">
        <property type="protein sequence ID" value="TBU53432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHW8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU53432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="496" mass="51071" checksum="42D90F76A6463B1A" modified="2019-07-31" version="1">MVYVNDKKFACESCIKGHRSSGCQHADRPLFEVKKKGRPVSQCDKCRELRKTKRMHGKCTCSSSSVPGTLSEAKAAGSADGPMSKSKSRRFKPIAPALPNGLKDVPTQDTLPDACLNLCRCGGKDASICTCAHDQGPSMRTDNGGLAALAQAALFCCGDDLPSASTSTSRVPSNSSERRTTAGPTEDMFSSQKRSCCSTVSRPPSPTPKRTKRSGTTPALSDQHIPRAPRCCSASSTPVYASSFSHAHTTYSAPPVFPAIHLPSASASIADSGCCCGAQCACPGCVQHRGSEHAAKDILDCEEGECRTCVDHDGGVALPEHALAFSQGRYGHTSSGASAVQQGAVSPPALVAGSSSTSGTSNSPTSARRARGDSVSYIDAFLATAASLPLPPPGRTRAGALDPTNVLVYPKSIFEGGDAERRSLFGLVEVPKLQCSCPGGCGCPEGQCACGEGCTGCAPEHGEVDGDGDVGEGEGEARSGSQTIQSLVGVGSCCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIF2</accession>
    <name>A0A4Q9PIF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminomethyltransferase folate-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_830482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145220">
        <property type="protein sequence ID" value="TBU53226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIF2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIF2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="1">
        <location>
            <begin position="71"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="1">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="304" mass="33632" checksum="6B54BE0E7098F0CA" modified="2019-07-31" version="1">MSVLTTTARFAVRASRPVARVPTTSRGVHTLPKLDYPYNMCPVARRLGRAKRPSYLECAMDGDLSRHSGILYDFHVSNGAKMVPFAGYSMPLSYGNGGAVASHHHVRNSVGLFDVGHMVQSNGIIDDTVITKHADDAFYVVTNAGRRDRDLAWFKERLEEWNTSEKAKAEGKVEHEVLEDWGLLALQGMRSAFVPIEGFNLHVARGGYTGEDGFEDLDEDTTPVEAGLTWVIGKERRENGQFIGADGSVTYGIPSPSLGKNIAKGYVNSGWHKKGDLDEIVIRVIDSGRYYCYWPYLSPLASFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PII1</accession>
    <name>A0A4Q9PII1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_887680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PII1"/>
    <dbReference type="OMA" id="CVLCHRE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF127">
        <property type="entry name" value="BLOODY FINGERS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="297" mass="34161" checksum="64803D3B036B7517" modified="2019-07-31" version="1">MAYCERCRRWFCSDQALWQHERTSSYHHFCAACDRDFVSETALTQHYMNSSRHTYCTLCSELIDDLDMSLSEHYEEAHYKCPGCHLVYRDRKSMLAHCEEEHADRWCIPCKRMFINANNLRQHQRSAIHQPATIRCPMKGCGKLFISTSHLVLHLESGTCTSGMTRKMIDDLVAKYDKRGIITNPERLIEGPSRSSPDVIKTWATERAWNGWAYECYVCHKTFSSLTALNAHLGSPVHGDKLYHCPKAYGGCGTEYRTLSAFLQHVESGRCGVIRFQDKFRKIIDDVAKGGRLLTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK92</accession>
    <name>A0A4Q9PK92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ARID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_969721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PK92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="493"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="731"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="746"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="959"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1084"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1223"/>
            <end position="1237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1309" mass="141794" checksum="555296BE19FBBE6F" modified="2019-07-31" version="1">MLPNNYVVGGQPGLPQPQPQPGPQQGMPNMGIDQNRMWQLQQQQQQQQQQLAAQLRAQQQGNGGQLNQQMLELLRQRGGVQANPQAMAQQRQFAGGVPQLGVNNSSPFPHDPSQGLPNAQPQFGNVPPGQNFTNFQTLARNPAQMFQNQGPMRQLDLMMAQNQQNQNGVSNPNPMAALQRQLAQQQQQQQQQQQQQQQQQQQQQQQQQQSHAQSQASHQQPSRMDAPQLPPGLFSNMNPVQMQHNLQNHPPQNGMGPNRAPNAMMPPMQEGQMQGQQHMRRPISIQEMSMKAHEFRQAIMAGENRIKALQSQAMTPQAPQDAIAAEISKVQKELMDRRQTLTKIMNFLRMNAVNGANPAYQNGVEMRTTGPSPVPPQRLPGGPQNPTQIGWMQQNPSQTPQFNSPRPVSTAAHLAPNATSQPSGPQMSTPQLQQQMAASQPNMPQRAIPTPLPVPNGGAPSHGGAQPTHNGRPNSLPNGVGPPFNMSYSPLTRENFTKAYFQQWIPKHPVDQTMLKVEGREIDLYQLHYEVMSQNGYRMNVQQIAPNQPPQLVPTLVISQEQWPVIAGRLGFVNFPGNGHEPARSGPAIAVHIEQVYKRCLQDFDSQYLRQLFQHRRLMILGQKVNGGDVSAGPSGPAAPQGLSDIKDPKALSEIISYAALSAPELQARGVPNHIIALVEKHRDQLKATLQQQRDFAKNIQIAAQGQPRNVSNPAMANANAMLHHQANSMNMANGMNGHAKPPMQPGQLPQGMSMPSTSSMPPNGQQQQQGQQRPGGAPGMLPISTGRPTPAQMAAAVEMVRRLKEENKHVQFPTTRPVHIGDAQRLEYNAQFEHLHRLVTTLDQKLPHLAVCMREDVIKKLVMMISVVQQQREMLSSNPTQYFMPLQWVQQMIMQVNQANHAFTTWVNNAMRSGPPADGSQAQAGPSTHSQPGPSTGPQRQGPLPVPRPPTAQPAPTPSALSPPGAPAHTPAASASSPHVVSTPSISKKPTPKPSGDVASAPTPTHINSPQTPRSPRNKPAPKPKAQPKQRKVSTKSGTAASPAAGPSETKLPATPAAATPANAPTPEPSSGSKRPREEESVASTSASAPPSAKKIKTEWDEAPSDILVKRQAEADGAKTDEDTVKFLEQMSSWLTQIGGEGDGQDILKTEIAESLDEILKAYPVAADDGMSLATSSFIESINVGSSSPKASAVDPADFFDFTSYGLPEEDSGSKADTPDLVQASSSVGPSPGSASETEVHPAASTGADIAKIADPKSEPSGGDSMSQDLWRAIDGGESAFYNSTDSWKWDQPMPALEQPWAIYSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKR4</accession>
    <name>A0A4Q9PKR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_858041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKR4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="556" mass="63355" checksum="25703B449973A637" modified="2019-07-31" version="1">MLHVLNNDVLLCVVDHLEATSHSLIPLSSTCRLLRDVCRPLIFRHLTRRLANEVSDSESFCPSTVSCLIQSLIIVDCCVQQEEGLKALFSQQGELLEDGSVRVSEVPFLCDHLDGPELMHALRRMPALRHLTLASSKGGILHGVRWRALKAVLSLPQLTEISLSGLLFSPLLPDDLRADDLVCPHLQHIKTFRYEVPSFRVSSWGTRERYPFHSEEEMLCRVLERLRHSVEMLALSSEPAPIQTMAQWRWPKLRELKLTGERWAEPLTPVVSLFAKMPHLRKLALELTLVRGQLSQVPPLWPRGYIGAFPWPNLTHLSLSHPHPEDELFTNLPSALRSLSLCCHPHKWQKLLLGGSGTVHHRYKYVVLDSSKMLIILSRCRTPQLTHLELEYNADEGENDLLRYLAASFPLLTSLQVHRYRAINNSQAQAMITGARTIDDVNFQAVDDFGRSLSELTHLRTLKAFLDYEDTPRPRFTQPRMSGFGYSREDANTFTATLHRAASVLSRAMSDAVRHICLWRPRGIDGYEWLVFRIVRGGLVTGLEVRCEEDLEHTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKS9</accession>
    <name>A0A4Q9PKS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Pkinase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_935339</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKS9"/>
    <dbReference type="SMR" id="A0A4Q9PKS9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKS9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20821">
        <property type="entry name" value="C1_MgcRacGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06627">
        <property type="entry name" value="STKc_Cdc7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF56">
        <property type="entry name" value="MAPKK KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="544"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="10">
        <location>
            <begin position="876"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="954"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="967"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1022"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1035"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1045"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1055"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU54706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1140" mass="123873" checksum="E69E5886FE266CA6" modified="2019-07-31" version="1">MQGQAGGRAASSPYGQNGRAAASTPNLSMSQLQRSTSPVGPGSPGVRKRWSPHQHLPTVRSDSPNEESSDGQTVNNDDVFGSTPNTNESRSSPRDRDEMRPSVPPRSPLRVRPVVERISIADSTRASMGDSVIGSLAESVELPVPVGMRQSQASSNLTDTTMFSSLLEPPRSPGSQNKFGTIRTVTTDATSFVASDAPSITRTEGSSIAPSFKEEGRKRAVDSPIRASRERRPSETAIVDLSRVVEETEDGATSRTRSDRTESDKARSPARAVPIKLGKGKWPDDFIGLDAFQAPKSSVLDEDEDDDSFGVSVHTPLSVSPPRSKLAFSARPANESVESLPQFPRRPTHRARHSVDTPGLLPKDQLLRRDSSPDASGSPPRRIVLRRSSSKAPSNRNGIYIPRNEGSASPEDAGSDVAVPFPRTVSGEHSTPPGAGFVFPSASPDGSKTDLLNGGAAPDRPRLLRGRFQSEVDAAGSRRKPRPNSFDEYGAKPARRSRFESMVNLGVASSNASASDLMSRDSYDGSAVRQTLIVREDGKAPTQFQLGNCIGRGQFGAVYRALNLNTGQMVAVKRIRLEGLKEDEIAQLMKEVDLVKSLSHPSIVKYEGMARDDDTLNIVLEYAENGSLGQTLKAFGKLNERLVANYVVKILEGLHYLHQNDVVHCDLKAANILTTKTGNVKLSDFGVSLNLRAMEREMKDVAGTPNWMAPEVIELKGASTKSDIWSLACTVIELLTGRPPYADIANSMSVMFRIVEDASPPLPEECSESLQDFLRMCFHKDPTKRPSAEQLCDHEWLKKHSAAHKHLQELRPQDSIPFLRRVSADMQKSKSIHFLADIGQQVSDPVAIDRRTSLDQPSSPIRPRLSNGQDAISPREHSFVKTTFGKPVICRVCLQSVKKSAVLCEQCSLIAHARCAPNAPPTCDLRSQLLLYAQYAESGNSVNPYSPMEILAAAAQGGPPTSPTSHTSDDGYSRRTSIESVQTPPNLSGVHGHVHPPTAFKVFSAFKRSRSSLTIDQDHQVQSSPASSSQPTRQVTHKKSVLRRKNTEVSERPRSISSNTSTTPNSASMRSAVTAAESVSSSHRRSQISADLSGRLSRMTSFSAVSAAETEREEPRVVGEMPRGHRDKRRDRESGGCSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL13</accession>
    <name>A0A4Q9PL13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_728494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL13"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="270" mass="29171" checksum="667BC80E3ACF966A" modified="2019-07-31" version="1">MVSENCDGLRGTLGCLLTDTADSATPRDADSGTSTSIQSSATHPQTGDGLSDILAETAHAAMADELHKISASIAQAHFTSSTAYPIPLVPMLCIATRAGIVPLMCSAMHQRKALGCEDIPVLGITQHQIESNSTLQILVGWIEESESNEDEHRMHIATSLSAGMRTSPDYGVFNLHDQSSTLAFSDFLIRVGLHFATIASSLPPERAVPGVDCECIHHWRDGPILETLSGDQLSEEWIREWNREVNDCRASLCNEGHLDCGFVSPTSWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLR8</accession>
    <name>A0A4Q9PLR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_934332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLR8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15121" checksum="B351A1B52165A218" modified="2019-07-31" version="1">MPSKHAPSFPATPSLVSLNTTACTSSIAPLKPIPSSSSQPAQKDYSKSFGLLQSQYGWGPATYAPTPILSNNKEPKKKRTGRDTRSTGVPEEKMGERQSGGKDYESVFGSLSSRYGFGGSWPMPTKKSKDFRSERVSVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM33</accession>
    <name>A0A4Q9PM33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_933944</name>
        <name evidence="9" type="ORF">BD311DRAFT_750230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM33"/>
    <dbReference type="STRING" id="114155.A0A4Q9PM33"/>
    <dbReference type="OMA" id="IMFTNFQ"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="16"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU32544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="487" mass="52888" checksum="4311D57B5A9118C1" modified="2019-07-31" version="1">MSNPEYKKPSLSQVSLIFACGTALFSDGYANNIIGSVNTLLVRIYGDKISADYSTTLSSLAFAGTVVGMLTFGYLSDKLGRKFGMMLATAIVAFFSLLSAASSGAHHSVGGLVAMLSACRFLLGIGIGAEYPCGSVAASEQSEEPGINKNAQHRWFALATNSMIDFGFVVSSFVPLVLFWIFGEHHLRAVWRLSVGLGFIPALLVFLWRLRMDEPTRYKKDSMARAKVPYLLILRRYWVRLVAISMTWFIYDFIVYPFGLYSSTVTNTITGGSSSLTVVFGWSVVINLFYMPGTLIGAFVVDYLGPKHTMILGLLGQAVIGFIMSGLYTQLTKHIAAFAVVYGIFLSFGELGPGNCLGMLAAKSGPTAVRGQFYGIAAAVGKVGAFGGTWAWKRIVSDFGKMHPNDPNIGQTGPFWVGSALAIVSAIITFFFIRPLSHDGMAEEDRKFREYLEQHGYDTSQMGLADVTNDTSSSSEYDEKKDGIPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PME3</accession>
    <name>A0A4Q9PME3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_825908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145169">
        <property type="protein sequence ID" value="TBU55391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PME3"/>
    <dbReference type="OMA" id="HTMNALY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="316" mass="34268" checksum="14A280B09B904369" modified="2019-07-31" version="1">MSLRTALTATARLHRMARQECRPDVFTRNVSSRVPLGKPSVSESEHALPSSASSPPSILRATGSSLPGSLPPEEEGPGELSDQEWEIRTGRAIYILQQTLPTFFSTGLISSVDTSGGNEKGDKSDEISIYSPNVRLEYRPPVPFPPPFPRTLHVEGLPLYMGSSVFVRHTLSALYTDLRVELQRVRVHGPRSSSGPPLDSSANPNAPGDIHRSQQSKTRSNREKSLFVGLMVHGINRVSKAEGGWQVNSTYTFSPITGLIHLHVIDSIHPAPHQAFFSALQAALSKIGLGSTRDAGESGMARAQPLSQPQPSRSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMG8</accession>
    <name>A0A4Q9PMG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_908365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145169">
        <property type="protein sequence ID" value="TBU55421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="19528" checksum="92E020FA6D0DD4F9" modified="2019-07-31" version="1">MHDTENSRTIAYSDLEDLCRKEVESALYNQASLVTPRERGTLHVPSRILHDLPWLHRSQDVDVFDDGLILLRLELSGLLVYLHVPKANIPDSGYARKVRSRYEMKLIVDAHRMRAEEFELRLKRAQEVSATSLLTVRRCLMTRPSSLVLTNHRPELKTQLSLSLNGDPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMJ4</accession>
    <name>A0A4Q9PMJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_825823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMJ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMJ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU55457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="337" mass="36448" checksum="9F0ACCC72D4F7E0E" modified="2019-07-31" version="1">MAFDMTKNTNLAVYWGQDGDDKQQSLSHYCQDDTIDTIPLAFLYQFKAKGGMPAIDFANTCSASGNSVFAGTALANCDSLADDIKTCQKAGKIVTLSIGGATGEVGFSSDSEAKTFADTIWNLFLGGESPVRPLGDAILDGVDLDIESGSPAHYAAFVNRIRSNAGENTSDKTKAKSRRARHRMLKRKKSSPTSSKNSTEIDVTTKDKKYYITAAPQCPYPDANIGEALNEAHFDAVYVQFYNNYCGLNHKSDYNFATWDNWAKTKSANPDVKVYIGAPASSKAAGEGYVSAETLASYVAEAQQKYSSFGGVMLWDADTAYNNNRFDKAAKNGLTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMV9</accession>
    <name>A0A4Q9PMV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_680147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMV9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="197" mass="22631" checksum="416B5FEF985794E3" modified="2019-07-31" version="1">MQMCNYWYVYGSSPYPQPNTCVPPPVSRSLFIHGDASREDVSKSLTADTPLSAPPCPSRLLGKWLKQSSVSAPATICNFARTCRQLYACSMLVLFTQVELRSRRRLCTFCDVLQAKPVSGPSSRLSPSESRRFALQYYPTFSDRVHRFQRMSRLIQCHISHIDSRMPPAAREQHSKRQYRLREAPNLTRLRSEDRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPE9</accession>
    <name>A0A4Q9PPE9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_931853</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPE9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPE9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000446">
        <property type="entry name" value="Microtubule associated serine/threonine kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="150"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="451"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU56193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="548" mass="62906" checksum="3915A0E36E0A811A" modified="2019-07-31" version="1">MAARSKHPNQNAYSELPDIHMNTAKGMTIGMSDIRMATAKGLTVDKDIRMETAKAGTTIRQGAFKMWEKELLESPEVRRKATVAQLYFLDYYFNLLGYIAARKERRARFDEDTAKRNLTQAEYAQEFKSYRGRERTLLRKRRVKLRVDQFQIIAQVGQGGYGEVFLARKADTREVCALKKMKKRTLFKMDEVRHVLVERDILTATKTPWLVRLLYAFQDPQHVYLAMEYVPGGDFRTLLNNAGVLKEEIARFYISEMFVAVNELHKLGYIHRDLKPENFLLDGTGHVKLTDFGLATGALNPQRIESLRVKLDRVKDNEVVHLSTLERRSIYRSMRQQIPRYADSIVGSPDYMAPEVLRGKPYSFSVDYWSLGCILFEFLAGFPPFSGRTPEETWTNLDKWTTVLRRPEYDAPEDQVFNLTDVAWDAITRLIAHASVRHATLGQVREHPFYAGIKWDDLRGSDPPYVPELTGEDDTGYYDDFTSPQDMEKYAEVIEKQRHVERVKEKEDPVSRGVWVGFTFRKNGPMAMGGGRAFGAGADDDGALATIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPV9</accession>
    <name>A0A4Q9PPV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_614868</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPV9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020290661" evidence="5">
        <location>
            <begin position="25"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="448"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="61"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="508" mass="53955" checksum="2D49A344669C78FD" modified="2019-07-31" version="1">MKFLTPSLLLYLSFLLNDVPKTQAIHLPIQGRIGGFGSGGLARRAGVTGTPDLSNQGNLQYQTNITVNGQQFQVLIDTGSSDLYVVGNVNGAKDTGKTGSVTYAIGSTKGPIKTATVEFEGFKIPNQAFIEQSVDSEHTEGSGIIGLGPSSASEIRGALGNSGGDPVLDRIFKQNSNTSNYITILLGRAGDPTDTFAGDITVGETVSPFDNVTSQPKLPVTEMSNRGGQHWTAMLDKNGIIGPDGNRINTTKHATGNKLTVMFDSGFTFPQVSANIANQIYGRVPGAVLANVSGGSAPMWTLPCSTELNVTFIFQNVSFPIHPLDTVTSALQGPPDSSGNPTCVGAFQPITTNIQGFDIILGMSFLRNAYMLINFGDFVDGSLAKVGDPYIQLLPLTDPAEAHADFVKIRMDGIDKSADLHLLPALPDSGDDGSSRDDGSSQDTLHKYLPYIIAGSVAVGVIILILIIAASYRASTKRKYRRLHDPAPAGLPASNSDPFQNYQPTRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS99</accession>
    <name>A0A4Q9PS99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RTA1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_968306</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS99"/>
    <dbReference type="STRING" id="114155.A0A4Q9PS99"/>
    <dbReference type="OMA" id="PYNNDAF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU57215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="302" mass="33709" checksum="71424436C47BA518" modified="2019-07-31" version="1">MSTRTSSVTAASAATTVDSIHPINNPYGYVPTEWICILFIVLFGVSTIIHLVQAIRSRLWWLLITACLAGIGEILGWSARLWSNQNVSNIEPYIMQITTTIIAPTPLIAANFVILGQIIRRMGQRYSRITAKWYTIIFCTFDLVALIVQAVGGAGAAGAVQKGNDPTPGGHIMLAGVSFQMVSLVFYVLLASEFIFRYAYDHPFARYGQSTVARRKTDPETKQMIFGLVLEAVFLFIRSIYRVVELSDGWKGKIIRTQWYFNVFDAAMIVLAMYTLNLFHPGRLLGKADAWASKDGEPKRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTQ2</accession>
    <name>A0A4Q9PTQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_820850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTQ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU57846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="524" mass="58201" checksum="9838856049314CF6" modified="2019-07-31" version="1">MTCTSLIFAFFILSSVAARSPLFNPHNSRPRIPHIDEPDESQPVYHFTSGQQISSYGETYYFDQLVDHTDPTKGTFKQRYWHNYEFYEPGGPIVLMTPGEESAKGFTGYLTNGTISGMIAQATNGSTIVIEHRFFGDSNPHPDLSVQSLQVHTIEQAIEDLAYFAKTVKLPQPDGDKLAPGKAPWILVGGSYSGALVSYTMHTHPELFYAGYASSAVVQAIGHFWKYFEPVREWMPANCSADVQAVIQYVDSVLDSGNTRDIADIKANFGLQDVIHLDDFAAALKAVFEDWQSNSITSRSNSFYEFCDALEVGPNGWHAPASGWGLEAALQAWGKYWNETLYPSRCGKLDAESCIGSHNPDSPHWTNASLPNSNRSWNWMICNQFGFWQVGAPEGTPRIVSSYLTAAHNERLCQYEFPGAFWGLKKVSLLNALTVDKTYGGWDTTTERLIFANGERDPWREATVAAALATRNSTDLQPHLLSDGFHCSDMSRGSAISPRIAAVQKQALQYMTQWHAAWKPSAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUU3</accession>
    <name>A0A4Q9PUU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_488716</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUU3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000158">
        <property type="entry name" value="Glycyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="150"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU58303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="651" mass="71774" checksum="463F6FF11B835991" modified="2019-07-31" version="1">MLEVDTTVMTPAPVFETSGHVARFADWMVKDLKTGEVLRADHLVGNVLEARLAGDKEARGLAAQPAKEDDKKKKKKDKAKAAPVKLSDEQVVEYETILAQLDNYSGPELGALCKKHNITNPDTGNEVSEPQQFNLMFASSIGPTGQHPGFLRPETAQGHFLNFSRLLEFNNGRVPFASAQIGRSFRNEISPRAGLLRVREFTMAEIEHFVDPEDKRHERFADVRAVALDLLDRDTQAAGSTRVTRMTIGDAVDKGVVANETLGYFLARIHQFLLKIGIDPARLRFRQHMANEMAHYATDCWDAEIQNSYGWTECVGCADRAAYDLSVHSAKTGHPLVVRQALKEPIVTEKLVAEFNKRTFGQTFGKDSAVIQTLVGGLDEALLAKLQGELAQGSTTVTSSDGREFKLTPDLLTIEKKTFKQSIREFTPNVIEPSFGLGRILYVLLEHSFWSREQDVERGVLSLPAVVAPTKVLIVPLSAKTEFDPLVREVCKCILARYLAGSPAPSFVPHGACSSYLSQCSLRAPSFPATKLRKAGVFSRVDDSNTSIGKRYARNDELGTPYGLTLDFACTSLSYSRLRHLLAAASSCLRRSHVPAVQNRTMTLRERDTTGQLIGSIDEVIDTVIELVNGSIDWAGACRRLPAYDGVQAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV56</accession>
    <name>A0A4Q9PV56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6902" checksum="21DA9E8BF4E5B943" modified="2019-07-31" version="1">MISRRLRSTWTRVQNAQSSVVLSSCLAFISRRRLRLHLHARTISHRGPGQCGALAGTNMITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVA1</accession>
    <name>A0A4Q9PVA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_926850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVA1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8175" checksum="3F0B2C85FCAF865E" modified="2019-07-31" version="1">MDMEHVGRVPPFVLLFLPSSACSLSPSLHRGLFLGQLGPFHRSYSFYLEHTQLANAFLLAQASCTTQGDAAVAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVS2</accession>
    <name>A0A4Q9PVS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sin3 associated polypeptide p18-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_926708</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVS2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="33353" checksum="F29EA6FA8CC569A7" modified="2019-07-31" version="1">MEETTASGRPIVDREKTAPFLIRTFVKIGTYHRLAQFEDGPLPLADEQQIYTWKDATLREVLTTLRSSAPASTEYRHPLARYSFRAVFADAAARGRYSQKDLGMVYSRDILGEPGSLDHTAPRLLEDVEPEASSSSESDKTLDELRFVPGDYLCVMVTLPKGVVLPSGPGGELSIKGSAVGGATNGWKGAGGGGRGDSGWGGTVAANPGPGSGRGGGGHWRGNSGPDHGVGRGGRGRGGDVGRDRDRDRERDRDRDRDFRDRDRDDRRAPPPRRDSPPPRRGDGGWGRRAPPSRSRSPPPRRRGRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW82</accession>
    <name>A0A4Q9PW82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucocorticoid receptor-like (DNA-binding domain)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_878349</name>
        <name evidence="4" type="ORF">BD311DRAFT_655149</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW82"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW82"/>
    <dbReference type="OrthoDB" id="413436at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1480:FF:000001">
        <property type="entry name" value="30S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836:SF19">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US14M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU32112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU58746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11426" checksum="42C1E4476BC85C10" modified="2019-07-31" version="1">MPTARVLRDIKARHGVNANEILRRAYLYVARNQTLPPQVRFQAQLQLNTFGRYTRPTTVKNRCTATGKGRGIISEFGLSRYQFRLKALANELPGVHKASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWG8</accession>
    <name>A0A4Q9PWG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_818527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWG8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="786" mass="83259" checksum="C9895C0FBCBAE926" modified="2019-07-31" version="1">MIPTASHPLTPAFASTGSDCSNASPLPPALDISSSLTLPAGHHPATPRFLLSLLATAVYLSIPSVASQALSAIVRTIGPHTAVRYLNFAIGHGIGPPGTPEIASIGMDQEFGAAAGLEDVAELIKEDDISYESIDRSTESQHKREVGKDAATTSSSSAKRETAKHTHNHGTPDSDAESDSESEGNSTFQKAKSQDMLHAQPTEPCYYYGAVSDKVGEAAACWLTRWGVDILRYEEQAIVSDTAERGGTDQKVPWSPSPHHVQWAGDRPGSAPPEMANSRSGGRVGGSNPKPVAPVVWRRGGLSARWIRGIISSDALFVRGEKERYEMAKSVVEMRRAASAMDGSGESEELEELEFGRLFTEGIYYANMHLDDLMSISKDVSRSTGKPFVPLATLQAALWNQSTLYHKITYRPAGSASPSLSPTNATKELGLGTATANIEQLASHPDESLKAFYPVPGDSSLRLGDSTGLEGASMDQLFDPQYGSGKRSTPLATEANFFGLEQARRPATAFASSSSPLSAPVDPEARWTAHPPFRFAVEFWDVDALKEKSRLHSHTVWYAGSLYNVYVQVVRKKGVQLGIYLHRQSTVDPIPPSSAPTAGMLPSPPRDRSVLGRGPSSSVSSPRPPSAMSGLSIPRSPLRPSGPPTPATPVAPGSPIAAALPAAPAFSRSSTTIHTSSTSVGSITVASPVSLPATAPPVTPPQPYRDPRPAVSAYFTIACASATGASLTRFTSAPDVFSVSQSWGWKSSSLRTEEYLEVDANGQPAPVIIPAGREVSLRATVVLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWL7</accession>
    <name>A0A4Q9PWL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_948282</name>
        <name evidence="2" type="ORF">BD311DRAFT_832490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143409">
        <property type="protein sequence ID" value="TBU29979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWL7"/>
    <dbReference type="OrthoDB" id="2751671at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="261" mass="29080" checksum="7E82D3DF659FD1FA" modified="2019-07-31" version="1">MSQNTPSESRASTSSKSTVSSLTTELDKLTTAVLEVTDHIQACSQASDAHHAAYIAHVEEQKKRTAGIQDRIAQMLAMTQESLKRDEEEPLKGALPHRLIAAVDPSDEQYCFVASSCAARQCPTPRNSGAICSGRRSGPEGTRTRRRGRPCWRRANRHWGRRSKARGIRRLARCRSQENGRRGLRVLCARREARIPCPSPTPSRACFQMPVHGRRCSVYLYVADRVDSLFHLTHELSDDVVSRMIAPGQLGQYSSSDILRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWT6</accession>
    <name>A0A4Q9PWT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1038726</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWT6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWT6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000079">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.960.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.960.10">
        <property type="entry name" value="Ribosomal protein L3, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044892">
        <property type="entry name" value="Ribosomal_L3_dom_3_arc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="388" mass="43847" checksum="BB4C9DA6A0DA0C96" modified="2019-07-31" version="1">MSHRKYEAPRHGSLGFLPRKRAARHRGKVKAFPKDDPKKPVHLTAILGYKAGMTHVVRDLERPGSKMHKREVVEAVTIVETPPLIVVGVVGYVETPRGLRTLTTVWASHLSDELKRRFYKNWYRSKKKAFTRYAKKHAEDGGKSIARELERIRKYCTVVRVLAHTQIRKTGLSQKKAHLMEIQVNGGSVADKVEFAHGLFEKPVEVSSVFEQDEVVDVIAVTKGHGFEGVTHRWGTKKLPRKTHKGLRKVACIGAWHPSKVMFSVARAGQNGYHHRTELNKKIYRIGRGEDDGNASTEHDITKKTITPLGGFPHYGIVKNDYLMLKGSIPGTKKRVITIRKSLMVHTSRRDLEKVQLKFIDTSSKFGHGAFQTFEEKAAFLGTLKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYQ4</accession>
    <name>A0A4Q9PYQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_924514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYQ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYQ4"/>
    <dbReference type="OMA" id="VWIEFRN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="420"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="445"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="604" mass="66074" checksum="45E0C3EDBC6AAAC2" modified="2019-07-31" version="1">MDALRSLVQPLVGGGGGSSMIDGMKLVVLGGTVETARRVASSGWSHFINSFFLTAHFSEEDYPYDWLMLWLSRRPEWQRSREFETTTRSSTPGFGSRIADNSFGDEDEEDDDAPGRVKTRVVFQPTANTTHTIYYRGHWLRVKRWRKSDTGSEVISVSVVARNNSILKQLVLQAKKEYEAEAVHRIQIYFADSHGCWRWTDSRHKRPMSSIVLNPGVKEMLLSDTKDFLKSEKWYADRGIPFRRGYLLYGVPGSGKSSLIHAIAGELMLDIYVVSLSSSWVNDGTLTTLMGRVPARCIVLLEDLDAAFTRSTSRDGSSTGNPDGKSEEKAAEQTTTTSSSSRRTRQKEQLSDVNTLTLSGLLNALDGVAASEGRLLFATTNHLERLDPALSRPGRMDVWIEFKNASKWQAEQLFRNFFPSTDEDDVPIEGDLDSIELPMVPPSPSAASSSGSTLFSLSSTFSSVPTTPSGSSSPLSPLPSLPEGLPARSRTSSTTGAGAAKGKNKERTRTVSDAGLQNQAYLPPPVEAEIMDAKHSAKPLDGATLAALAKKFADSIPDEEFSVAALQGCECSNFRSCTYRGLLLRPSSSLLRSSLVDEAAAEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYR2</accession>
    <name>A0A4Q9PYR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYR2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="17978" checksum="79A58B47EFF99F13" modified="2019-07-31" version="1">MPWYRTSYPAAPLVALQARQHISDDDVEQNWPGTCAKGGQNFGLQEKARSRRADRRVCTKTRRSSTSAHIDIGAHIHILRGDISAGSPVHASRRSSGYEPTVPAWTASRSGVRSQRTHLRPRCSSRPVATLVTAPSSEAQDERREGMATSATRTWACGGDLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYZ6</accession>
    <name>A0A4Q9PYZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_924223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYZ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="SUZ"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="61"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="207" mass="21798" checksum="A094B8F0301B53E8" modified="2019-07-31" version="1">MSSAQSKIQTDSWGSPAATSIQRRAQPASDHIRDDWDDDEVELGEVEDPQKVWEEANKRARMPELVIAGSSTSGPSVTSPPPAAFQPVLRILKRPTATPSPSTSPSSVSASSSPSSNAPSSTYAEREARYQAARDRIFGDSSPSSDTPGELGLQTPQALKKSPPPVEITREPKGPPIAQAGADGRGQGGDIRGFGSRRGKRKGAGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZB0</accession>
    <name>A0A4Q9PZB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12625" checksum="1D7B8984219B29BE" modified="2019-07-31" version="1">MVIHDHGARNWPTLSGNHKRLLMLANSHIVRQTPAIKHLRAWIPTMVEKVTTQSTACHCASPALNHLLQNPHLSTPRLHPPFITRYNLPVLQHAPWDLMFVSHAKTAVATNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZJ0</accession>
    <name>A0A4Q9PZJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZJ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="326" mass="37264" checksum="5F341277F5860D53" modified="2019-07-31" version="1">MPVEIFHQIFSYFIFDRHKETLSSCALVSKFWLQVARPHLFAMMQVERKRCFSTFLRFIDLHPDLAGHIQELTFASARYRSRDDADECCCDDHERPKDDPEAWPPPPRLDLGALTVVFPKLTKLKELMLQEITVAIPKSAPSASPDANAYCARKLEVLVIKDVTTCEHDNGPVLPAVLDALSPSSIESLIFDRLGKNPRCDTPDHSEDPDVTLEANLLDLWGTRPPLDVQHLSLSDPSWVGTAAHFRFYEQKMVQPGCLRSLETRCDSWKITEQVFAFLHTCGSKHFECLQLDIIPLVENEMPFSEYCSITSESRMRPMEQSRVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZJ9</accession>
    <name>A0A4Q9PZJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_338870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <end position="28"/>
        </location>
    </feature>
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        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10428" checksum="4BF4188A46B411A3" modified="2019-07-31" version="1">MDSPVHGRNAKDAKRHQRRDIRTRHYHATSRNVTRAAQGILLTLFLDGVMTYLGGRCGIRRERTPPIRNNEESTAGEMGVRTRELSRVGWD</sequence>
</entry>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <source>
            <dbReference type="EMBL" id="TBU60231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="119" mass="12772" checksum="A96B069F536EF1CF" modified="2019-07-31" version="1">MSGTSRPRLCDILIALLRTSSRSSHGVRSLLVLAIVYLAQREALTSSPTLVRPIMPISKASSDESATQFPPLSVACPKRLTNEGHCQPSPVAVAMFTVYSTRASEYVTPPVRSEASPVC</sequence>
</entry>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <end position="112"/>
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            <end position="148"/>
        </location>
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            <begin position="87"/>
            <end position="97"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU60094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16173" checksum="2A40400A03C8B9D1" modified="2019-07-31" version="1">MDNASVNDVLARKLAQLLLKRYQVSFAPENAQIHCVAHVVNLIVQKILSNVLDIDDPALADYYELYNKHLPIHYDLADDEDLKQWETEGSTSDSVGNQDEEDANASDIEDELGGELQDFVSGNFGNGSKAAVDKASPVTCASHPETAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0Z9</accession>
    <name>A0A4Q9Q0Z9_9APHY</name>
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        <submittedName>
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        </submittedName>
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        <name evidence="7" type="ORF">BD310DRAFT_922781</name>
    </gene>
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        </lineage>
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    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
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    <dbReference type="GO" id="GO:0016620">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ald_DH/histidinol_DH"/>
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    </dbReference>
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        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42986:SF1">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="15"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
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        <source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1E2</accession>
    <name>A0A4Q9Q1E2_9APHY</name>
    <protein>
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        </submittedName>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1E2"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22359" checksum="54082162A230EBFB" modified="2019-07-31" version="1">MSSHPALLKHDIFLKIMCCFSSVQQPPDIDMRREDAYWGPPHPNKNQIKGEDDEDLVLDVTDRVKRMTSARLAVTCKAVSTSYRLPPVVASIRCFASSPLLYDNLTVYTKRLRVRLSWATTLSHGSSVPFIRALPNVTFSSTPGVRSARNGQRPLSAAGTTTRPKTPQRRSATERRATRGPGYWPGPCDCTVSTYVVAGPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2Y3</accession>
    <name>A0A4Q9Q2Y3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_174418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2Y3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2Y3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="558" mass="60817" checksum="D0B97922C0915BDD" modified="2019-07-31" version="1">MKPPNDLWDKNLLEEEPFLSQFMIRNGLTQNRRGDNWIATLAKEVHDNESSRAAAVQWSSQYAFAPEGKTQTKNIDHASLGSVEIFVRFYWALYSDKEQAALDVVNRERRKRGFSFQFELSRRPQNSGCIRAGRASTQIQKEQEIASYEHSSQTSLSRGSRGKRAPRKPTTSVGRDAAGRTASGKSRKAADATSTDGGTMVTGATGRDKSSAQSGGSAQTAEFSSSGSLTHTPDADARDPWAAMTFPEEDKGVVVFRGDHDAVAFEVAHSQPQNDPPPCMTVAHDQQASGDRTDSASSSPTVVCPSTPSDVSGTTAAEPPVGFGKGRGRRARRDGPTEPTRQRPPRAATNHGKLSQLAKDEFKYYSKAKRGLVDDLEDLAVPANGAQQSASAPPTRRAKRSRVRTASEDRDDPMLPPADHGEAERMSGPTSASIAVHPAAPEAARRIPRSKYARPKPRRGEKGNEKERERNIRGADSSYPRASHRTLNIGGRSLSPRIPMSVCLMMVIEEPLQRHLPLCLQGASLIRPLWLPRLAGTPPPPSMAFRTLPEYLQAPGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q351</accession>
    <name>A0A4Q9Q351_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peroxisome targeting signal receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_920296</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q351"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q351"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF9">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="499"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="533"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="644" mass="70802" checksum="0326B4B434983DA2" modified="2019-07-31" version="1">MSLQGLISGAECAVPFNPLSQVVKHTEGDRSLQQDRVAGPSGSRLHHLPTSSAPHGSQQDLAMARQFFEGGPQQAGAPPSFAVPRHVMPHEPERFMSAPAQAGPDLTKAWNEMQAGRAAPGEMLRSHTASGGWSAEFDGVSQIARPSSQQNMPMQSNFNQTSYMQPGLYGRGMPVGMSYGMGMGMSQMSMDHGKGKARDIDFDAAFAQVHASFADQTEGARITEVTDDELEQLAEGLDSASLDKGKSKATEDVPYEETNFQEVWDQLQNSDIPPPKEEMAKWEAQFNQMMNAQREDLDFDYGGMMQNAWESTGNSEFSADPVLEFDDQGIPALGEYVFEKDNKFLDPTHSRSTLQQAKDLLAQNGSLSEAALLLEAAIQHGDLGEGGYEAWILLGETRSMDERDDAAMRALSEGVKRAEAAGAAGAGMLSLAIAYTNESLERASHTMLLRWLHARFPDAKISEEQWKSLSLSSWHSQEQVTEAYLAIAREQYTRGEVDPDVQIGLGVLFYTSGDYNRAKDCFEAALSMRPKDYLLWNRLGSCLSNGNKPEEALGAYREALQLRPTYTRAIYNVGVACLNIGAHKEAIEHFLSALALQESSGGGKSEQLWTTLRRAFQAMDRMDLADMARPETNLEAFRDKGFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q353</accession>
    <name>A0A4Q9Q353_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_873160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q353"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q353"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051481">
        <property type="entry name" value="BTB-POZ/Galectin-3-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410:SF41">
        <property type="entry name" value="HL07962P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24410">
        <property type="entry name" value="HL07962P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="84"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="512" mass="56635" checksum="CCD60227FE966E66" modified="2019-07-31" version="1">MNPPHILIARNSRGPNTHNPSASLSSPTETHAAAAGIFRSAGSPSWYFEEYESDGMTSSLSTNGDMDDPIEIDETFTLTSKFPGNVKIVVESTTFWAHKEILYFASAFFQAALSGGWAETEKESGRPQSVSSVITISQPPVVPGSKPDLETHSEITFAPMDPDMDPDELDLDIDISDSDASDAEASTEDKTRAREDSLSKLEKSNPTTPTSPSEKAKAKAPDIDGNTAGPSTLRRTRLFRRQAPEKEKRPDAIIVLKEEKASTFHDFLKYVYPHLVCTITWNNVEGLMNISHKLHVSALQNECLTFLLTHAAGRPIKAMRIAELFDEEELYRESSRFVLDNPGGWSEEELGTLSQATLLKLEKRRTWFLERVLKLGLVQIAKEYQCCLSCPDSANCARLLDEKWKQAYQAVFRFGPCQPSMVFRYLRTLEGVSPPLSLTHLSCQTTAKAFVATLFDRMFSLGVRGSGTDTAPLGARVAAVAGSATSGPRRHFLYCSLHGDTNQRSKRSREQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3D4</accession>
    <name>A0A4Q9Q3D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_145942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3D4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020880797" evidence="1">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11969" checksum="780E91F8288A6694" modified="2019-07-31" version="1">MVMLFLNCLQLGFTLAAIGPTRKVLNVSEVTIFSEPITSVLITRFLFDLQLVNRRAVLDQDSDSPPYTDMVATSSTLRFGSFIDSLGSTISSIDGERHEDSSLPVDPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3E3</accession>
    <name>A0A4Q9Q3E3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_812048</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3E3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="400"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU61797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="480" mass="53876" checksum="C78335911A4AF4E2" modified="2019-07-31" version="1">MTPVPDYKVRKHFPPGPRQQPLVGNLKDIPSGGNEWDAYEALGKKCGIDVVYFNALGSHLVVLNKFEAARELLDKKGSIYSSRPRLVMINELWGWDWNLIMMPLGKAFQAYRKVVQQEFQPSVVAESHRIIIARETIAMLGRLMKTPDRLPEHLKQMAGATIMAITYGHHVTSADDEFVALAEAVREHAEKTPGSSIVDVIPLLKYLPSWFPGAQFQRDAEIMRRLSLDMRLAPYNAVKKLIDYGTAVPSIITRLIQSESPLEGVPAGEFAMNAAGVIYSGITVSALLNFALAMSLYPEVQERAQQDLDRVVGRDRLPTFEDRQELPYVSNLVKETLRWKAVSPLALLLTARCNSAMLHDESVYTSPHEFDPNRYNPTPKRPTGEPDPSRAAFGFGRRICPGRYFADDALFLAIACMLHVFKISDPSESRERAQVQWSSGLVRRVSPLVPSPFPYKIIPRFSGAQDLSRVSERCIMKATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3P1</accession>
    <name>A0A4Q9Q3P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Fcf2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_920077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3P1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3P1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039883">
        <property type="entry name" value="Fcf2/DNTTIP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21686:SF12">
        <property type="entry name" value="DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="4">
        <location>
            <begin position="181"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="83"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="312" mass="33534" checksum="15D5864253E6E3C5" modified="2019-07-31" version="1">MAVTALEKGKGRARPEDLEADEIEQTSAASASSADSDSSGSDSDSDSPDDFSSSGSDSNSEDDVAPEFLESLLTQARQNVRAKAKQLAGGGGEEEFIQLGGDEGDNDTTAKPLPPLDTGSLPAPYITLPETRGAVPSKLRDPDVEHVQKVASSIQVPAAPAPPELTKDGKKLTKKERKQMKNKTAGPAWFDLPAPAEADLPRLYREVEALRLHKQLDPKQFYRKEPGEGKGIKGLPKHFAIGRILPTDTPFGGASADNLPRTARKRTLVDELVDDAEAKSYAKKKFKELQTVRGAKGRGTLAAKKALRKPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3Q4</accession>
    <name>A0A4Q9Q3Q4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_152409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3Q4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3Q4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="39101" checksum="D8D7510B7EA4F86E" modified="2019-07-31" version="1">MSWTDFKPFRPSLPTETEENIIDLLWDDVHALRSCSLTCRAWLPRSRLHLLYAIILRNREHLIALQDTLEKYPARRLLVHSVTTAPKPRKSSPRSLIEVFPLALLMQLSNLRCWKISQTTTKVIKRREALSFHRTTLTRLRYSSIDELHLTSIRLASCTEFIRLILALPRLRKLHCDDLHLAAVGTGLDSLKDIASDRLTNLSILELTRMKAADVDLLLGVTCKSLHSISIVHIKGAKFSAGAFIMQPMQSITRPLTRHSASSDHRHAVDVAVIFHHSRVESTAERAARQRADSHLPQPLVDSASLGPTPYKLWYNASFGECRAVGQLDEGYHAREHAGRLSRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3T7</accession>
    <name>A0A4Q9Q3T7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">COMPASS complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_966022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="entry name" value="RBBP5/Swd1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44040:SF1">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
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    </dbReference>
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        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="80"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="50878" checksum="ED7639175B3E0295" modified="2019-07-31" version="1">MNRAVANLFTSPYPTAIQTSLDSYASIARYDPSGRFIVAGRVDGIAIVWDLDTKGPVRTCEGHVKGITSVECVAISSCGLLWSHNSRYVLTSSKDWNVIVWDLASDSEPPRRRSTIRFDVPVVFASFHPKNSKIILVLLSSGEVYIVDQRKEYKGRYELIEALDESDDEGQYNRSRSAPTAARFDPSGKHVFVGTTLGTLLVFNTRTKTMIARHKIAGAGIIRGLEFVASGRRIVTNSSDRVLRQFNLPVYAPPNADGEYIEQELEPTHRFHDPISKVSWHAMSYSPDGEWLAGGAADDAAHKIYIWDLAREGLLASTLDGGRELLTYVHWHPHKPSIASVTNLGNIFIWHCPTDERWGAFAGGFEEVDENVEYEEREDEFDIEDEAEIARRKMLEEEEDVDIESGVEEVNGTADHTRQNGENDEDILWALEEPDDDMKGWELKVIMDEEDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3V7</accession>
    <name>A0A4Q9Q3V7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Voltage-gated potassium channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_812451</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="TBU61952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q3V7"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:voltage-gated potassium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001508">
        <property type="term" value="P:action potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Potassium voltage-gated channel subfamily G member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028325">
        <property type="entry name" value="VG_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537:SF254">
        <property type="entry name" value="POTASSIUM VOLTAGE-GATED CHANNEL PROTEIN SHAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11537">
        <property type="entry name" value="VOLTAGE-GATED POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00169">
        <property type="entry name" value="KCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
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            <end position="151"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <end position="235"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="13">
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            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Ion transport" evidence="14">
        <location>
            <begin position="69"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
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            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
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        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU61952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="446" mass="49694" checksum="06E7E0B8B1E54E0F" modified="2019-07-31" version="1">MSQTIPLSRISTGARSLPYNAPHDSPSGPDYQNGFQYDDVDEGQNMKPSWKKDLYMLLEKPTSSQAAFLVHIFTTFLISFSAVVTVLETVPAFHSIPGSIWFGLETTLVVLFTIEYIGRCVAHGTSWKRFFNWIISFFGIIDLLGILPYYIEIALQQDTSTLFRFTILRTFRLLRVFRPFRYNNTILLHKLTANTTFSTIEVMYLSFRRSQHALLALSFFVVMVLVVFSTLLYFAERGTWDEALGVFLNSDGDPSQFASIPAAGWFVLVTITTVGYGEITPRSFLGRLITLPLLVFGLLLIALPTFVLGREFSIVWEFMEEAQKTREQDQDIDPFHDPLASPLLSSRHTQGIAAATASLWRHAAEEATLPRPSRVASSSGAVHGSPNPAASSDHTQAGLSTQLAELRAKVDAQEEILRRIMAAVEGPGANQKQNRGIGSQQGSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q442</accession>
    <name>A0A4Q9Q442_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_904681</name>
        <name evidence="9" type="ORF">BD311DRAFT_659802</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143408">
        <property type="protein sequence ID" value="TBU30176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU61384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF6">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE AN1598-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU30176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="416" mass="47171" checksum="1D2AB5ECABC2795D" modified="2019-07-31" version="1">MPPPLSSRLSPTLLYIAMDDLRSIFWTLAVSFTAYILMRRRFDPLRSIPTVGGPSVPGIFYPNLAALNFVRNAKELLTIGHEKYRGAAFKVAFMGRWIVVVSDSKHLDEIKSHPELSIAEGLDEFLQLKHTIGATAQSDRFHVNAIRDQLTRSLNVVMPAVAEELALAIPEYIPCTGDGPWISGARRSIQQTVRILKPIFYERKTKLQEYGADWTDRPSLTHALYDLATHPGFIQPLRDEIESVIAADGWTKRGMNNLWKLDSFLRESQRVNGLFLISLARKAMKDVTLHDGTFLPKGTFIVADQCTVHNDDNNYEHADQFDPFRFARMREVPGEDLKHQLVTTSREYLPFGHGKHACPGRFFASMELKAVMSYLLVNYDIALDGSLRPENQYFGIDISPDPSGRVLFRRREPRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q498</accession>
    <name>A0A4Q9Q498_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_811681</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q498"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q498"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="17" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU62009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="12172" checksum="11F95C2F999D5173" modified="2019-07-31" version="1">MPSSSSLRTLQRRICSSRNLPGCRRYASHGHGPQYNEPTGYLFAEKPLPAGQKRKKEAWENVWYLGMYGTMGLAAVLLYYKPDTSIQAWALQEAKARMEARGEKPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4H7</accession>
    <name>A0A4Q9Q4H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4H7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4H7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="32"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="59807" checksum="9F5B2811CE266773" modified="2019-07-31" version="1">MSYRTHLTVLEQSAALYSSSPAFKLPRVSAIDKTVVEEWVSVSYEQFLLDVERSARHWARTLFAHGLPSRSIVGLWLGGTTYLDVLHVYGIARAGYIPQLFSLRLPSPDVVYELLHRAGAQALVFDPAFASIVVNCPIPAELAVDIRSIDVSDAVLPPLWVPSNGDEIVMIYHTSGSTSGSPKLVPCTADWVNATVQKAAHVTRPRSSERQDVTVWIGSMSHIGQTFMLMGFLQHGSCTVQPTQLPFSSVELLDMIRRCGLNRLNQFASFLGTHLRNARSNPALLAALKSLDELLYTGLPLAAEEEAWAYANGILIKNCFGSTEVGAMMLSVGGRGKDAAHLHVIEGTAYEFRPVTPSTERDAEASKSETGYADANQRLLELVILSHSGDCPHPSLRDPDGHYHTGDLFLEVAPGRYVSRGRDDDWIKSATALRCDTKAIEENVLATCADIVAACIVVGNGRPSPALFVEPKGDLDAEKLKRDIIRRTRHFHARRYVHERIVSAAFVVVVPAGTLPRTATKGNIRRKAVEEKFRDELDRIYATC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q674</accession>
    <name>A0A4Q9Q674_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q674"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q674"/>
    <dbReference type="OMA" id="PRHATID"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="40219" checksum="499339F2E17244F0" modified="2019-07-31" version="1">MADPTGVDIDLTLGVILVGLIVTAGLLGVTTAQSGSYFVHFPQDRRALKILVIAVWLLDVTHLGLYLSTMYTYLVKKEGLHFGQKPLPWTANAQLLVNACGISLIQSFYASRIWQLSRMRLLLVIMGLFIATTWLLSFVLFVKTITTNTVAEYVHLEPYDITMSAMTASTDVLLCGALVVLLTMFRKDTQGADRLINRLLIFTVNTGLLTSVHAIMSVIMVVSLPQTSLFVMFYYIGTRLYSVSLLATLNARIELRMQAERMGDRSLPEIPVTAPPLGLTNRKSSQAQATVLRRGDKSDILVTMPCKSETATITTGDGSNPTTLNPAPPRIFCEGNRCYVVPDGEFKSFWTPDFLADSAPVLALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6Y3</accession>
    <name>A0A4Q9Q6Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_618595</name>
        <name evidence="10" type="ORF">BD311DRAFT_713179</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6Y3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6Y3"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000119">
        <property type="entry name" value="Ubiquitin specific peptidase 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="113"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="536"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="626"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="672" mass="73008" checksum="4118405844274185" modified="2019-07-31" version="1">MLASPLLPSPRFAEESSYRPAKDLDAFNKLLPPPIEFVEGSSSGVLAVGEGKYQPINESPKKTVADSHEFKKVQQTASTKATKPTSESPNHHKFIYTGPIETSWPNVSKPVGCGLGNTGNTCFLNSALQCLLHTPPLLHILSKHPESCHSPKSNNASCMICVLRQVMQDVFTKPHSTIPYPVITKLHVIAKHMRRGRQEDSHEFLRYFVDALQRSALAGAPPKVDPKLAEKTWVYKIFGGLLRSRVSCLSCGYNSDTFDRMLDLSVDIAGVASLRDALRKFVAVDHLRGADKYKCEKCKKPVNADKQFTIHEAPAVLTVHLKRFSPMGRKIAIPIRYDERLSLEPFMSEGSFGPNYTLYGVISHAGNGPNSGHYYAHVKGANGRWHEMNDDYVAPLSGVPTSLKNAYILFYILEKGQALEAALAPRAVTPSRPTPPTSKIAGMKKRKVPDSETEDGRSSSAKTPKFIGPLLPSEQTASPMKDAGKADPQAETLKKKIAAAQCQSGKGALQSLAAYGDEDEDDDVGEKVSQEDDSAESPTAKAPSAPPASITATAPVQPRTEPAESPTSPAAGGIPPDSFYGTSTPKTTDRKRKTPDGEEDDASYKAWARTPITPSSSHKGRRHSSTPRISATNPYTQLKGGNNLHATRGSQLSSPGPDRRKPRHGPKQRLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7P8</accession>
    <name>A0A4Q9Q7P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_841647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7P8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7P8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="79"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="286"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="687" mass="78326" checksum="CCB387D06A7CB23D" modified="2019-07-31" version="1">MDPSRIVIRVGPRQSALRQALLKLRDPNEKRLLQDNIENFLETWIPRRDGGEDTSRKIMRVLDTHTGRFVWIDPVQEEYAILSHTWDPAGEQAYSSVRNLQLSTDSTLFQNPALSFKVMQACAIARRDGFRYIWIDSCCIDKSSSSELSEAINSMFDWYRRAALCYAFLADVPNRAHSDALSRFEGSRWFKRGWTLQELIAPRSLVFLSADWEVFGTKTTLIATVAKVTGVEEGVLRHQKALSSVPVVVRMSWAANRETTRVEDRAYSLFGIFNIRLNALYGEGENAFIRLQEEILLRIPDQTIFAWGSGMTSHLGPSPLPRSPLSKITLYENARTRPRFLLPLSPKDFAESGQIYPIPPGRWNDFGLSNIPIPEFTTSPYGIRTQLPLLPIAVYFGKAQFDSTLSSNKAWYLVIFACEHSSYRGRVLARVCFARRSQDPQHPKLLQRGFIVLSDPPRDNIRGCFDIVTLDWTQLRDWRSELLVQTVYIPFTNPATSLRRELPPSPTITSPSSLGKPALRIILEEWCRAALAAQGYEDKLDFLIIGRKGRKRETLGLHCLLLSRHDLVIRLEFEFQYLRNSTAPGHSLQVTASTFSPTAPQSLPMNLISEYDDRAVTQWYGESGFPDIELKTQAGDRMTLVLHIAEVPPKDEDPDAHWFKLRVEIIEEHTENSAQLKENIDRDDSPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q883</accession>
    <name>A0A4Q9Q883_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_915663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q883"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="10417" checksum="2DF59268B32B4125" modified="2019-07-31" version="1">MILGRSLYLTIPFTPTLCSLASPEEYHPRLSRFLCVSVLRRLERFPFQPYAPWWILSIPTPVMNPYVYTPRDFMYHELEMTEPGSDCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA39</accession>
    <name>A0A4Q9QA39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase II-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_944270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA39"/>
    <dbReference type="STRING" id="114155.A0A4Q9QA39"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="967"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1094" mass="122731" checksum="166FF135DCE9EA18" modified="2019-07-31" version="1">MNGATSSPPPGRTIDIELGGQEVITVELDSLDPNPDDLLEVLKEGQCKVWIWTRLAAEYWRRGLLDAAEKIAKTALQALQDTDSSGSVSPVFSFLATLQIAMAAKAPKLILTDAVHDRMVAERTREDYYKEGTMYFNSGERVAAEYGESHMMLSSLTRGILQLSSGQWDDAARTFDSVLSDKPTNVVALLGKAKIAYARRQYTQSLKLFQRVLQLNPTCLPDPRIGIGLCLWAMDHKAKAKAAWQRSVEVNPGEWSAHLLLGLEALNASKNEGQSEEERREEFLTGTRLIERAFNANQRNSAAANALCELFLQKGQTKMALKLAERTIQFADVKGILCDGYIRAGRVTHREGLLQDATSHFTKAKDARKDSVLATIGLAQVQLKNDETAGAIHTLDTFLQTAQNPKSVELMAMLASIRATPRPGMSDKDKVEEKARARDLFDRVCKSIGAGTDGLAQLNGQTQNLTPSARKLGEDAEMFIEIAKLYQDESIERMERAYKQALQNSEASGKIEPRLVNNLGALQHLEGHFDEARAMYETALTHAASLDQSTAEAMSTSILYNLARVYEDQAEVTKAKEAYDKLLMRHPEYADAKLRQAQMLAEMNQYNDAHELIKQALASQPNNLNLRAFYTHFLVQSNQAKYAKDFVFVTLRDHDKYDVYSLCAAGWLQYHQARENRDGSPEGIKDRRRGFQRSAEFYEKALQLDSLCAVAAQGLAIVVAEDALGNLGGALGPPAPDENAKRLKNSREALDIFAKVRESINDGSVYANMGHCHYARDEFDKAIESYETASKRFYHNKNVSALLCLCRAWYAKANKDQSFSSMTMALQYAQKALHLHPFDKAILYNIAMIQQKAAELLMSVPPAKRSLKDLQKAIEQAGHAQKLFASLAADKSPLVPYNRDLADQRRKYGESMLRRCEDHLATQKQWEADAQAKIEAARQRRQEEKERQDAAERARLEELRKQAEKLAEERRIAREQAQEWTREVRRMESDEEKEKAAKKAKRGKRTEHVSGDEGVEGEPKPKKRKGKLKKSADSGAENEDEALFSGEDEDQKPKKRTKKRAVRDDDEDEPAVAAPRKKQYKSKETISDSDEEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAB9</accession>
    <name>A0A4Q9QAB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_807109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAB9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAB9"/>
    <dbReference type="OMA" id="GPTECIG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="235" mass="25333" checksum="BE46E6F2D7F6CC34" modified="2019-07-31" version="1">MLAATFAALSLLAHVFPIVHATVLYPLIVQSGGPWSGAEDAVKVPVTLGVMSACPDAILCESVFDHVVQRVADKVDLTLTFIGKLNSSEPDFGVTCMHGSNECAGNVQELCAIKYAPFQQWWPFVQCQNFQGRYEVGKPETALKCAKAADLDWENSGVGACAGLSGDGKGEEGIRLLQKSVVETRLLGVEKSCTVIINGKQVCIRDGAWKQCEGGHAPSDFIRQIEEEFDKLNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCM1</accession>
    <name>A0A4Q9QCM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCM1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="64967" checksum="53EC4C476609F153" modified="2019-07-31" version="1">MIRLTDFPDDILEEIFHAMRSLMCFPGERHSEPLYPHDHDDDGEDYRNVYGPRRRPVPLWANVIALSHVCTHWRRLMLTRPRLWTFLRVTGSFANRMMINEMLERTGGFPISVLFTHPFHTDSEPDGDPSAVYDLLALASVIGDCSERIQELGIVLDTSEQVALVLDTLGRCPVPMLDKLWLDSADANSGSGFAAARTSLLDHAMPPLRVLHARNISVPWLPYERLVRLELACGPAPPLAALLHTLRASPQLELLALRTATPKADLRRPPHALADEPRAFLPRLRRLQLHVGPLFDAAFSVLPHIAFAPRTTAVTLRFDGRVSSPLYEDCGSLEALAGAVRRAAFVLHRPTLASFSSLPPSPYSDADADAEPFAPLTVLWRLSEDEGRSPRARRPRRVPRLCEGLKAVPLPALTELSVALVPFYDADAREPAERDDVARLRRLWESVRTVRRLEVGVHPAHARRVFAALGARAREVPLGEAGEGQGIGEEGGEEEEELEEEEGEEEEDSWGEGAEGEIVCPALRSLRVNWWTRPGVDELWCVERCCLARASAGARLECLETVEFPEIVLASLRHHVDRIEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEZ4</accession>
    <name>A0A4Q9QEZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_943357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU65836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="319" mass="35900" checksum="04C4C561BC3821B5" modified="2019-07-31" version="1">MSQHSIKLNDGREIPWLAFGTGTALYTKDAEDAVTAAIRKGFVHLDGAQMYKNEDSLGKAIATAGVPREKLFVTTKLAQLSQGQTVRESLLESLKRLQLDHVDLFLIHMPTWYEGRLKDIWKQFEALKEEGLAKSIGVSNFRIKDFQELGLEDGSVRFPPAVNQLEYHPYVYKASVPLIEYQRKHNIVTTSYGGLTPIFRKPGGPVDETLEDIRKRLEKDTGKTVTQGQVLGLWLRALGIPQITTTTKESRLQEYLDTLALPDLTPEEVEAINTNGSKLHYRAFVRVPIRYVDPSNAMPFFCRPLSWTINTPLGQSAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFJ3</accession>
    <name>A0A4Q9QFJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_18117</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFJ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10939" checksum="F3F1A43EBAA0A8B1" modified="2019-07-31" version="1">MHSFSERSCVDYGVGISCGWFACPPSWSMSDGLTTQPPATLHVLQRAEHSLPACRTTTGFRPCRAVRRSFPAHILPGSSGSLATNYLFWTNVSPPADREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFT6</accession>
    <name>A0A4Q9QFT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_803184</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFT6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFT6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF3">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020620939" description="Cytochrome b561 domain-containing protein" evidence="8">
        <location>
            <begin position="25"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="9">
        <location>
            <begin position="185"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU66111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="364" mass="38447" checksum="41CA8DF55046A29E" modified="2019-07-31" version="1">MRISLAHLPKPLLAVLLVTVSSWSSGPSVLQGDSWCGTLMCVSATVNTSIVTYQLKALNQLGWMAIGFGDQMVNTPLVIIWQTANGTIILSQRQASGLVEPLPVTDPPRQATVALQASILSGVSPILAFDIPKNNDTVQPLVWAFGLTVPPADPSASIEQHLDAGNLSLNLTKVLADPSSESVHTSTTTTQTGAIATTLGLAPSQSSPTSAATIPSHTDSVLVAHAALSAAGFLILLPLGALVARWARVFTPKWFTAHWFINVVLGIPLICVGWALGPLAVARRGMGHIVTPHQQISGVVLFALYVFEVALGTVVHLRRPKDGKHHPPRNIIHVVLGLAVFGLSIYTVSAPRSLLPPKRSIGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6J3</accession>
    <name>A0A4V2K6J3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_940230</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6J3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="187"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="428"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="448"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU52443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="461" mass="50385" checksum="CEB02DA19B4EB276" modified="2019-07-31" version="1">MSTNPYRPSDNLPSYIVTDGHQYPPNASPTPVAPVPRLSDASRVYGFAPTYVPSPSLSHPNSSFATHTSMPNLDDDDDKDSGTRVEIREFMRTPSPTPSEKYVLTHKSRSCDIKKYFTREKLRQPKHILTIAITLVVVIVLILFLAFQQKVVNWMRPFANWMHDTPGGWILPIAIMFVLSFPPLFGHEIIAVLCGDVWGVWIGFGIVAAGTLLGELGNFYAFKYWCMARGKKMEETQMRYAVLAQVVREGGFKIPVIMRLSAIPGHFLTAIFSTLGMSVWTFIAAATLGLPKQLAVVYIGVSQSSSGSHKTANAVKAIVIVATVIVTHLAMLYIYRKMDEVKAGVVYKRRKARQAKMLAAAGYPLPDGAIPMPVDIDLERARDVESRSGVSMRTAVAGSQATSDPFATSGDTMASMAAVSAGIQRIGPGARGLSASEGDVPSPGRARRAAERRNGERELQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6N0</accession>
    <name>A0A4V2K6N0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6N0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11683" checksum="8D0F49ED863721DF" modified="2019-07-31" version="1">MSNYLEAQAIVTEARYFSQTPIVFCILKFEPSVLRFNTNCELAALTLFLYDCLVTIDSEVTLFWLPGRVNGAVSLFLVNRYFTLVAQILGFAPQPKKFNRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7L8</accession>
    <name>A0A4V2K7L8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">PapD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_950005</name>
        <name evidence="9" type="ORF">BD311DRAFT_740199</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143437">
        <property type="protein sequence ID" value="TBU27044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7L8"/>
    <dbReference type="STRING" id="114155.A0A4V2K7L8"/>
    <dbReference type="OMA" id="FNRPFTQ"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160219">
        <property type="term" value="C:cortical endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140506">
        <property type="term" value="F:endoplasmic reticulum-autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160214">
        <property type="term" value="F:endoplasmic reticulum-plasma membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033149">
        <property type="term" value="F:FFAT motif binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051685">
        <property type="term" value="P:maintenance of ER location"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902647">
        <property type="term" value="P:negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000813">
        <property type="entry name" value="Vesicle-associated protein 1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="2"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="303"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU27044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="383" mass="41731" checksum="DAB11922483F6EC8" modified="2019-07-31" version="1">MSVSLNPSSVLGFNRPFTESVKRTLQITNNNANPVAFKVKTTAPKLYCVRPNSGRVEPGETVEVAVMLQAMKEDLPLNAKCKDKFLIQSTIITPEKESMPLQEIWNGEADEVHSQKIRVVYLPPEGQTVPEEDETHVNMSSLLNVPGQDVSSVWSESGLTRFPETSSIYSQKYATVRQYQTNGHADREHSGGDDSATRILPPQEEEHHDAPSTPPPNVAVHPPEPTPSEPQPSSDEGVGIVNVSVHAPPPARQSPPPSPLTRAVPPPAPQVIVQDPNPELVKKLDEAQAEIERLRQLIASMPEPSVAPTSVTGATELRQRRRGPASDDGSSYDGRTYDDRSTYDGRTEVGSYVGSDIAPPEGVPLQVVIIIALGVFVTTYLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8H7</accession>
    <name>A0A4V2K8H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_816149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8H7"/>
    <dbReference type="STRING" id="114155.A0A4V2K8H7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="385" mass="40341" checksum="4FA189A000A807FB" modified="2019-07-31" version="1">MRPATALAAALLSFAPGALATYSLVREYSGSSFFTGWDFYGNYDNLTNGDVTWVTQANATQSKLAYVDDAGHAVIKVDNTTFVPYNYKRDSVRITSTDYFPVGSVFVFDANHLPYGCSVWPSFWTKGQNWPIGGEIDIIEAVNLMTYNQMALHTQDGCTQPSSVTQSGTTGSTNCTQDAGCTVAENQSNSYGDNFANAGGGVWAAQLDSSGIFIWFWTRASVPSSVSGANNSIDTSSWGTPSAAYPSSSCNITEFFTPQQLVLDITLCGDWAGGASVYESTCGGDGSATACYIDNVINNGSNYADAYFSINYVKVFSLTDGVLVPSVSGGSTVLVTESATDATSEPSATSTTGAQSGNKAATLGANAYVAVAGATVLAAVSWILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8N2</accession>
    <name>A0A4V2K8N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Short chain oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_814994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8N2"/>
    <dbReference type="STRING" id="114155.A0A4V2K8N2"/>
    <dbReference type="OMA" id="AWQLGPK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="247" mass="26117" checksum="9A21ECE56EE56AEB" modified="2019-07-31" version="1">MVDIAPTRIAIITGAAQGIGEAIALRLADDGIDVVVNDLPVKKDKLDWVAKAIQAKGRRSLAVLGDATVEADVVSLVEKAVEAFGGLNIMVANAGTIQRVPIVDTTIEDWDRVINVNLRSVMLAYKHAARQMIKQGRGGRIIGAASMAGKKGFAYFPSYCASKFAVRGLTQSVALELAEHNITVNSYAPGIIPTGLTERAEDEKNGGRCSTFLLAAGLPLNVPIGTTAMIAELVAYLVKPEAQFMTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K935</accession>
    <name>A0A4V2K935_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidoreductase AflY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K935"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="55962" checksum="8D6C88AC82614917" modified="2019-07-31" version="1">MTGNTTASPKLPPTIRQGILNLPGTTPEAKRVAERVLEEDRQKHHCFYGRVGFHNHLSHHLLAVYDLGAPAALLQKIYDREAESQSDIETWERKSGKIEAAHETITNENWTNFLGDERYYPSYLEFFTKRITELGAGQVLEKYVFAPAANGNEAYMLLRFVGGALHPLIQTGYGAEFSSDAMIAQALAQTAVHNAFYPELFDAPPPLTVLDYKARRPTHRQPHRGSSLLHILRQAYDSEIMKPVMPYDPDALLSARFKSAFEDGTRVKEIRRLSALWQVDASRGQLEFDEKVEELLWTATLLLVGTGKPGHKARLDFFLMHLLNASLFVPSLLRAVPTTESKAALLRAIPPVLLAYLTIRGRPRIDPGLAMSFTEFPRPPPNVDVAEPHADAVGDPRDPKDHNPWPVIVSDVLHAPDAHTVKAVRALYYAAQKYGRIPPGEVIGAFDAEGRETHPGIAKVDGTLFVRAAGVVMDTLGWVAHGQKEGGWDRSALGWDDAWKNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2KA15</accession>
    <name>A0A4V2KA15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_912604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2KA15"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU66028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9915" checksum="A7102D398FB29C02" modified="2019-07-31" version="1">MSDHHKPSSNQPVTLARPITLTSVFHLLLGIVIPSFIPLCGHRLLASGLVCIRDIYLLIDVVHQEKLPGLFRTKLVLMPTISARQGRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWB0</accession>
    <name>A0A4V6MWB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_933697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="37295" checksum="D62944AB0CFC5CE4" modified="2019-07-31" version="1">MSTQKALIFPEKNGEWKLADRPIPTPGPEDVLVKVVAAALNPADWKIPDYNMISAYPWIAGGDGAGIVEQVGSAVTNVAKGDKVLFEADWVTVDKATFQQYAVVPAQLTAKIPENISFDQAASVPLGLATVTTGLWNHHPDAKSVHFTAPYEEGGQTKYAGKPAFILGGSSSVGQYAIQVAKLSSFSPIITTASSHNEALLKSFGATHVLDRSLPASTLAAEVAKIAGGKPVEFVYDAISLADTQALGYEVLAPGGVLVVTNPVAIPEEKKKVGDNKKIVNVFGVVHTPENREFGAEQYSRLTEWLKTGVIVPNRVEVLPNGLAGIPEGLERLKNNKVSGVKLIARPQETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWK5</accession>
    <name>A0A4V6MWK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_983032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145455">
        <property type="protein sequence ID" value="TBU51003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWK5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10080" checksum="C7A4DA352D1B9FC0" modified="2019-07-31" version="1">MTLSTFVTRAHRNLDGKILNPTRPLQNLMLKLVEAESTNNLFAEFMAIVRLSPTNVFLDGWADVEPLPGYDSGVVVSQRPQEQVATPAPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M4Q4</accession>
    <name>A0A4Q9M4Q4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_963163</name>
        <name evidence="4" type="ORF">BD311DRAFT_792509</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143569">
        <property type="protein sequence ID" value="TBU21894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145378">
        <property type="protein sequence ID" value="TBU51149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M4Q4"/>
    <dbReference type="STRING" id="114155.A0A4Q9M4Q4"/>
    <dbReference type="OrthoDB" id="7340501at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10211">
        <property type="entry name" value="ASKHA_NBD_Arp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU21894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU51149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="733" mass="82996" checksum="25FCA750AD289700" modified="2019-07-31" version="1">MEVDESNITFLPIQPLPTVQVPATDYDDHRDAHTPLCIDNGSTHLRFGFCTSDTPRTGINMVAKYKERKTNKPLLLFGEGIDVEGGARSQAKTPWEGDVLLNFDALENALDYAFIHLGIDTPAVDHPILMTERLASPLHSRALTSELMFEQYSVPSLAFCVDSVMSFYHNNLPSPPVPFRDDGLVVSFNTASTSVIPILDGKGIMSHAKRINWGASQATDYLLKLIQLKYPTFPSRVTPTQCNWMLQNFCEFSPDYPALLRKLKDPLNLRASERIIQFPYQVPVTEEKTEEELARIAERKKEQGRKLQELAAKSRMEKLVQKETDLAHLLSVRERKEEESKREWADTLREEGFANDAALEAAIKKLEADLKKARKKEADGEDAENEEPPSFPLVDVPDEDLDEEGLKEKKKQKLMKAGYEARERAKREKEREREERAAEEKREEEERDRDLSGWATKMRREQETLMNRIKERNRRRAALTDRKSAASQARMKSIANLAADDRVPKKRRKAGGEDMFGADDADWAIYRKINTAAASSDEEEDFAALAAVEQKLLAHDPTFTEEHTHAALSSQRSALMSAFRPAYDEGDPQGKARIHLNIERWRACEAWFSPSMAGIDSAGLGEVLQNVLARFSDADKGRLVNNVFLTGAPSQLPGLRDRLHATLRPILPPEMPLEIVRAADPVLDAWRGMADFAKTDEFKKVGVTRAEYEEWGGERVKRWWGGNWNASVPLKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M764</accession>
    <name>A0A4Q9M764_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_831779</name>
        <name evidence="2" type="ORF">BD311DRAFT_733737</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143566">
        <property type="protein sequence ID" value="TBU21938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145242">
        <property type="protein sequence ID" value="TBU52645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M764"/>
    <dbReference type="OMA" id="IHRSYDY"/>
    <dbReference type="OrthoDB" id="2501127at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="21066" checksum="A314C09AED5FE5B7" modified="2019-07-31" version="1">MASINGFRVALYVVLWLFSAVLLGLTATRLHYTLFLPPFDPLNSGKPFYDPIVAELLVTSILALFWSSYIIHVIHRSYDYGRFSSFAAELLGLMALFTLFLVGAAISSTFWGDLFWCHEFWQCRLLTALVAFAWMCWVMTFALIVISVLFAVANSAFFHPLHGRYDPHSSFFGGNRKDRRSRWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MG40</accession>
    <name>A0A4Q9MG40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_808675</name>
        <name evidence="2" type="ORF">BD311DRAFT_488501</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143456">
        <property type="protein sequence ID" value="TBU25707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MG40"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="152" mass="16507" checksum="48FA226D2E1BB624" modified="2019-07-31" version="1">MDGRIGYGVSCARIFAGEIPVVACMGADGTSTRHSLASRDWSVSSTTASNPSTQSASLSCRRERTKGTTSLGILTFDGAHREDDATLAVTFGFKEVDDVFGLSHQRARVARLPWVKEGKVQSVHFPKLLYAECDQLWTPPTGSYARPNLRQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MG58</accession>
    <name>A0A4Q9MG58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_949708</name>
        <name evidence="2" type="ORF">BD311DRAFT_780753</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143472">
        <property type="protein sequence ID" value="TBU24811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MG58"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU24811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7184" checksum="428B34F5A8A92FE7" modified="2019-07-31" version="1">MSDTHPDQARRYESGPPRTARRSHGSSDVLAVRTSARHHFERRDDRCCRGTSKRRVALISHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAW3</accession>
    <name>A0A4Q9NAW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_833227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145275">
        <property type="protein sequence ID" value="TBU51953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAW3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NAW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33295" checksum="0BBFB349832137C8" modified="2019-07-31" version="1">MSFLADRSPIFRDMFLIPQPPPSTATTEADSVAPRVVELPDCTEDVYDLLRVLVPAGAASRPFSSHIIPTFDTISACIRLGHKYQIDDIVEAGVGYLRDFFPRSLDAYREIVSPAGPPAFERVHAIGVVNLARLTGASEVLPTAIMRCASLPGSQLIAGFRRRDGTHETLSEHDLALCVDAQRALMREHVWHAIELSAPFVNGNCVDRARGSSSGTRLCVHVAKLVAAERAGEATAANVFEERDWPREGAGDLGVVVRGGGSRLCASCVEVLRRMEARCMQDTWNRLPEIVGVPLKGWGRKSLKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB90</accession>
    <name>A0A4Q9NB90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_953335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145345">
        <property type="protein sequence ID" value="TBU51291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB90"/>
    <dbReference type="STRING" id="114155.A0A4Q9NB90"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="374" mass="43138" checksum="93525336FE2612A0" modified="2019-07-31" version="1">MPPLIPDDVYDFAPFEDRPSFEFAELLFEKMRSSSGDMDQLLRILSAKCVIKTDGQELSNGFFPSTDTMYQTIDDVDFGEIEWKTITVRYTGPMDADAHWMHEEYEFHCRAINQALVNTAGNAEFEGSWDYVPFEEFPSENDHRFSNLMSARFAWKQVKIGAMLVPLILGADKTTVSVATGHQEFHPVYASAGNLDNSMRRAHGEGVIPAAFLPIPKTVRQHSYSAAFRTFKKQLYHDALAHVLAPLRPWMTTPRVIRRPDRHYRRAIIELGPFIADYSEQVYVSGVVSKWCPKCRARPTELENEGPPRFRAHRPFTHRFPRADIHELLPPDLLHQLIKGTFKDHLVEWVTQYIHLTAENEAEAKRMMDDIDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCP1</accession>
    <name>A0A4Q9NCP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_976436</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCP1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19368" checksum="54D6B6023FA201E4" modified="2019-07-31" version="1">MSRNVPSVALSRPPRQSGRFACSAPLHHLLPLPLPPPPSPSPLPLQPTAHEPPPDKRRPYGSTRASQSQSPVTHLAPPACSHSGQSSPSFNSPPPASHPSLSRPSRTPHTSPHLPPSSPSTVSTPVSRRPSASPPAFESVRPDDRRLKLNLNALRQCPDSSSRPRARSTVSDHRDLPRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDI2</accession>
    <name>A0A4Q9NDI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Epoxide hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_929607</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDI2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="45761" checksum="EE905ED376FDEDA1" modified="2019-07-31" version="1">MSSAKLFTLAVSDAELHLLHRKLELARFPDELDGAGWDYGVPLADVKRLAEHWKDRFDWRKFEAKLNNLPMFTQDIEVEGFGSLNIHFIHQRSEVPNAIPLLFVHGWPGSFLEVLKLLPLLTASSPDHPSFHVVAPSLPGFAFSEAPRKPGFSGYQYAEVLNKLMLSLGYQEYVYQGGDFGHTLGVYAVNKFGHKHIKAWHSNMPVYRVPTFSSHPLLYLEMLTMPINKYIRDIISAALQIRKTEFGYFTLQATKPQTLAYSHSDSPVGLLAWIYEKLVKASDSYPWTDDEVLEWISVYWFSRAGPAACTRIYYELTHGNTTDMFVGTKWTSVPLGVSYFPREPIRLPEQWAHTIGKVVHQSRHDRGGHFAAFEQPEALVGDLRGMFRRGGPAYGVVPDKDGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHK9</accession>
    <name>A0A4Q9NHK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_833041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145269">
        <property type="protein sequence ID" value="TBU52059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHK9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6548" checksum="380AB94E03CD3517" modified="2019-07-31" version="1" fragment="single">SFRIAVLDGWLLVITGPMLIDALRHSPNDRLSFTAGITQVSLMSIYGRRHCVACVGSSMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NI56</accession>
    <name>A0A4Q9NI56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_878281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="4"/>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NI56"/>
    <dbReference type="STRING" id="114155.A0A4Q9NI56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="417" mass="43905" checksum="28A33F75D2BCDBE8" modified="2019-07-31" version="1">MFAARITIPSSASRPFLRHLRRNMSSSVQRHEAVIVAASRTPVGSINGSLKALTAPQLGSIALKHAFEKSGVKPESVEEIYFGNVVQAGVGQSPARQVAIGAGVPSRSDATTINKVCASGLKAVMLAAQSIESGYKSVVVAGGMESMSNAPFLIPRTNPVYGKFTALDSLENDALWDVYNKIAMGVCGESAAEKHGITREAQDAHAIESYKRAERAWKAGQFKEEIAPVVIKGKKGDVVVEEDEEYKRVIYEKVPTLQPSFKKPNGTITPANSSSLNDGASALILMSAEKARELGIKPLAKVVSYADAGVDPIDFPEAPTFALPTALERAGLKVDDITHFEINEAFSVVVRIAEKKLGIDPAKINPHGGAVALGHAVGNSGSRILVTLVHSLKSGEYGAAGICNGGGAASALVLQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NI87</accession>
    <name>A0A4Q9NI87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_938428</name>
        <name evidence="3" type="ORF">BD311DRAFT_726105</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143446">
        <property type="protein sequence ID" value="TBU26433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NI87"/>
    <dbReference type="STRING" id="114155.A0A4Q9NI87"/>
    <dbReference type="OMA" id="EKPAIFW"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU26433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8423" checksum="E8B4DD80730787A8" modified="2019-07-31" version="1">MAAAWTRTYRYLQRQAHEQPVIFYSVIIGLIGPVMVVTVPPIRKSLGWKPAEPIPTSYPVPNRPRRAISGYDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NID1</accession>
    <name>A0A4Q9NID1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Drug/metabolite transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_952184</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NID1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EamA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="5">
        <location>
            <begin position="155"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="292" mass="31702" checksum="A5FF28B7E981BCD2" modified="2019-07-31" version="1">MSVFVKKLNEVDPPVHPLELIWVRMVMTWVVCVAYMSVTKVPKPVLGPKGIRTLLAYRGLSGFVGLFGTYYALQYLSLSDVTVLSFLTPMCTAATGALLLKENLTARQMIASVFSFVGVVLIARPEFLFGRQHQDEQIDEAESLRIVTSAQRLVAVSVALLGVVGLTSAYTTIRAIGKRAHPMHNLGAFSLFCILTAPILMVFAQIQFVVPDNVSCSAMILAVSGCGFAAQMTMTSGLQRETAGRGTMAIYVQVIFALVFERMFFHTTPPPLSIIGTVIILSSAIYVAVSVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJH3</accession>
    <name>A0A4Q9NJH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_919830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJH3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJH3"/>
    <dbReference type="OMA" id="GHIQLNL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="261" mass="29521" checksum="5A689DB247FB1080" modified="2019-07-31" version="1">MARGPKKHLKRLAAPSSWMLDKLSGTYAPRPSPGPHKLRESLPLTIFLRNRLKYALTGREVTSIVQQRLIKVDGKVRTDPTYPAGFMDVITIEKSGEHFRLLYDVKGRFTIHRITPEEATYKLLKVRKVAIGNRGVPYIVTHDGRTIRYPDPVIKVNDTVRFDIDQGKITDFVKFDTGNLVFITGGRNRGRAGVITHREKHVGGFDIVHVKDSLDRTFATRISNIFVIGEGTKSWVSLPKGKGIKLTIAEERDVRRKQRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKR1</accession>
    <name>A0A4Q9NKR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_945108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKR1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="6975" checksum="D39961F11481EBF4" modified="2019-07-31" version="1">MRDFGLLGGEGFGGFGAGLLGTIAGESFRVGVRLGGDTGGGRELAAAWEVARVVVFSGLLFDLVSALDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPZ2</accession>
    <name>A0A4Q9NPZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_922852</name>
        <name evidence="2" type="ORF">BD311DRAFT_732980</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143544">
        <property type="protein sequence ID" value="TBU22392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPZ2"/>
    <dbReference type="OrthoDB" id="9978173at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU22392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="48232" checksum="0FC44E8E5968BA92" modified="2019-07-31" version="1">MPVTFQVASHKANSFELDKSYTPSVDNILEESCRPQWRRCKEILQSSLEADEVLTMVPYSNGFVHAVLDAYGAHRHLRIRPDDVWLAIVVQLNFYINAHAEELRSYFVAHEGKKKLVLQAAGDRYAVDYGSLAQTFTKRIHENVVDDTLVKWILPDFTTTTTRDTTVCSIVIMASLKEYFEYVIDCICGIPSVTLEGEKSDWVEIYRRLERLYDFGKEPSVWAEMLRPILRRFISAFDGEPDVEFWSHVAYHHSEMCGREDLSGWITAFCVWSHKGEWNSVSLPESTPVKPSFVLIDSESRRKRLSKIIPRFLRRNAKSPGRSEEDSAQEANDKPSGSVMIRHSWRRGNPTYTLDNVPFSVLDATMIPPGYCEVDVTVNDNGVKLECMMVAGHVAYSTSSTAGNEKMDTVRPSAQWFMFERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTY7</accession>
    <name>A0A4Q9NTY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_926901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTY7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20096" checksum="7391BC5CE7D55E29" modified="2019-07-31" version="1">MYNRSQKYTRARQPVTRRSSWKVCRGSGCPSQSQPLSLLGSSSTFGWMKWFRIGPSLFWRRSRAAGAAWTASANARTRRARTERMMASFGAGPEGGDGQRAARGAYKYSRPSPNLHSNALCSWPDRYGKEGRLWSGGKSHRALRACFAESIFCQCGTAAGASFCAGARAVLRTGAKKACGKPVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV49</accession>
    <name>A0A4Q9NV49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_783850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6340" checksum="2D622D5DAEEE857E" modified="2019-07-31" version="1" fragment="single">GYPLVQPDNRSAQHQRPEKVALVEKLPGMRMFLNDATVVSVPSLSELLIKLTQKQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYE7</accession>
    <name>A0A4Q9NYE7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Adenylosuccinate synthetase</fullName>
            <shortName evidence="11">AMPSase</shortName>
            <shortName evidence="11">AdSS</shortName>
            <ecNumber evidence="11 12">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_887836</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Plays an important role in the de novo pathway of purine nucleotide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11 12">
            <text>IMP + L-aspartate + GTP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="11 12"/>
    <dbReference type="EMBL" id="ML145215">
        <property type="protein sequence ID" value="TBU53391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYE7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NYE7"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.170.10:FF:000001">
        <property type="entry name" value="Adenylosuccinate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.300.10:FF:000002">
        <property type="entry name" value="Adenylosuccinate synthetase, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002223">
        <property type="entry name" value="PRK01117.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 11 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="8 11 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="301"/>
            <end position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="333"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="415"/>
            <end position="417"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU53391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="432" mass="47286" checksum="FFA4D93A477BD1E8" modified="2019-07-31" version="1">MSATVVLGAQWGDEGKGKLVDILSADFDICARCAGGNNAGHTIVVPIGPEKVNKTFAFHLLPSGLVNPTCTGIIGNGVVVHVPSFFAELDALQQQGLDCTGRLFISDRAHLVFDFHQIVDGLKEVELGGSSIGTTKKGIGPAYSSKASRSGLRVHHLFDHDTFAQKFRKLVENRFKRYGHFEYDTEGEIIRYKQLAERLRPYVIDSVVYIHKALAENKKVLVEGANALMLDIDFGTYPFVTSSSTTIGGVCTGLGIPPKKIGKTIGVIKAYTTRVGGGPFPTEQLNDIGTHLQEVGREYGTTTGRRRRCGWLDLVVMKHSCLINGYDSLNLTKLDVLDDLEEIKVAVKYVINDKELAGFPADLEELAKVEVVYVTLPGWKQSIAEARTIEDLAENCQKYIGFIEQFLGVPIEWIGVGPGRASMVKKEGFLVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P020</accession>
    <name>A0A4Q9P020_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_323384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P020"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="614" mass="64299" checksum="4209D447085C4E78" modified="2019-07-31" version="1">MYPPPSPIFDVPELPATLRRVKPLPKRRRTSDPTSHDDHGFRTSSPAPGMGTGVNTPQESHDGADDNVPATPDPTFAAQMALQAYYGPVLGGVRDLFKNMPTPDRGRAGEDDASRTSTPISIDLSAALAAGFGTGAGWYGSVVGGLGGLGGGYEQDDEDGDGGDYVDHLQQPGNTKKRKVPANMSGSAHGHDGGSGGSGAEDEAGDRAMPTGRERDVDAVAGGVVGAGTGGGGGGGGGAHGSLALAGKKGRLSRATLAGLQHKAMLRSRKRQLATVLGTLAHGDTLALDQALSAHHIFVQPHTRVHLSRRRTSRFARALKAYMQSHPPGEGEGESKENEVPSSDFTFVFHSATSERLVATNGEVAELHGRFQAELARQAAKAAEAAKQAAAALSGPLAKRTNGTKQAPRTTAGKGSDAKGTLEQSLLGTKGKGGKKKKRSALANASNPHHLRNYVPSRLPHSGPPSAQQAMQNAQNLLTPLPLRFLSAEIPPRRRKKSEPNVTPVSTLTNPAEEWICPFCEYQLFYGDDQSYARAVRNRKKILRRRRRARERAAAAASGATAAAAAEKAQDDEVHPGFETPAPLPVAKETPPAAGKQAKWKEGDRGGHGVAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P352</accession>
    <name>A0A4Q9P352_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_814550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P352"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="82" mass="8806" checksum="8D975F706D3A2451" modified="2019-07-31" version="1" fragment="single">TRRSSPASRATLTKPPTASCNAPDTADASPKPVSAHLGYVRGHDDRRGTDTGPNGCARHTRAAERRQERWERVRGQAAIGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3V1</accession>
    <name>A0A4Q9P3V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_915465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="385" mass="40638" checksum="D980E64F620BF8A0" modified="2019-07-31" version="1">MSNTFHLGDSIIGASISRREGSSRFFSAMSRTCSAARVDLSSFGTLSSEEEYFSVDSGGEVDSNLSDSVMGDGESNAAHACDSLRLQSHETGMLRDRGSAHYKPSWASSTSSTSEEEVEKGYEADSDAAVNSNHDLGQTNGKPRHLRRRSRMHFLVQRVEPAEELAHRQATTDIPTVPLALWASKSPKGTSAGPSNAGSSASESSPEGTDCLVEHVQSIVSTVDVPPPLSPARASSGLVPSSSPDSGTFEEIDLNGDVCPPSAVLSQPSPGRDILPGQASVSAEPAPISPITPVALRPLVVGAPRPRLTRMPAFPSPIPVALRSSVVGPPRPRLTRMPAFPSPILLVTPVTRQPLAISAPRPRLTRMPKFPATVQLVAMKPGMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5K3</accession>
    <name>A0A4Q9P5K3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Translation protein SH3-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_906372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5K3"/>
    <dbReference type="STRING" id="114155.A0A4Q9P5K3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19266" checksum="3913384A32C9EED5" modified="2019-07-31" version="1">MLNALRRCAQRLMSTAAQPYPYSNAAIIPPPPAVPAPAPTKAGKGLMAHLPQRLLTPEKLQLLARFGKRHPERILPGSVLQVTTKYAPTSFTGVLLAIRRRGADTSFLLRNVINRTGVEVQFFVCSPHVREIKVLMRAGGRGSEGRAGPRMRRAKLFYLRDAPDKMTAISAGMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5U0</accession>
    <name>A0A4Q9P5U0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_840483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5U0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P5U0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008571">
        <property type="entry name" value="HerA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42957:SF1">
        <property type="entry name" value="HELICASE MJ1565-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="495" mass="53366" checksum="98A635A797EC453D" modified="2019-07-31" version="1">MAPPSSPLDSRSTASQGSGNSTRSSSPHSASTSATSLFGSEEEMQLLNLEPSIEDATDEHEVITAPLLTRGAYEAAGMALKKSQYGVLGSVSAICEKGGSYKPHDPRLYVNTNAPFSAIVCGVQGSGKSHTVSVLLENMLVSGCAAIGNSHKTLSGLVLHFGEGGSGSLPCEAAFIGQSRIEGACPPKVKVYVSRSSIHTMRRVYSVLGDNVSLEPLQFSESELDAQAILSMMAIGTSESAPLYMHRVLSILRDLGERFTYAQFLKQIEIAKKEMNAMQTNALDQRLVLLKTYVDGSAAKSKTRFGPGQLTIIDLSDPFIDPPMACALFEIVTRLFVRADVGTGKVLVVDEAHKYLSSNRSFTGLTKALTELTRQQRHLAMRVIISTQEPTVLPPVLIDLCSIAILHRFSSPAWWEAIIKRVSADFSDEDAFDHVVKLKTGEAIILAPSGLGVFPSRTCVGAPGLQHFGRRYLHVRTRRRVTADGGASRMVVQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6B4</accession>
    <name>A0A4Q9P6B4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_930666</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6B4"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6B4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="432"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="250"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="515"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU56859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="681" mass="77162" checksum="6756348AA59358D9" modified="2019-07-31" version="1">MAASEQNFSGALATWKNINLAELQKTLDAQGIEVVENQKEGVVGRKALADRTREFKKSPDEEKLTAIKGLLKAYQTEIDNLTKRCKTAENAFLNVYKVLAEAPDPYPLLEAAVDQTVKVAEARDLEAELQRTREENVDLRKRLSETSSLESAKRKAESRVEQLEQKMDDLIQEKVTQKENELNATYDEKMRNYEEREQDLQRQLALTKNQLRDLRSSHESNQAKLLDHTQRQDQEVVAKLAELDMMVADLEHANSRIATVERRNELLRAEIEAMKSGHEGTARITEYETKIADLETETDRLSQALEAQKAAAEEAQSAASKKIDELGREIQKKAAEVDQYKAKLKQYADYDEIKRELEIMKYVEFAGLEDDDDATLNGDALGLHLPDPNADKANAQRGKPLEVLLATKNKRILEELTKFRIMHGELEAALQSVKSQLELTESELDKQRALNEKLETDLLQMDQRKGDTGDRASSANGTSTPVDVLASLELGKKAGESPARSTPIPFAPSADTSILPIVTSQRDRFRQRNAELEEELRKQFNIISELRAEVKSLQADNLKLYEKVRYMQSYREDSSTRPSTLDPLPSIAAGRPDDMSKYRARYEEAMNPFQAFRGREATRAYESLNVLERGVLVLTRAILGNRRTRTAFIFYAFALHLLVLFTLYECSTSSGSSVQRPQKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6N0</accession>
    <name>A0A4Q9P6N0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytoskeleton assembly control protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_1035532</name>
        <name evidence="9" type="ORF">BD311DRAFT_710644</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLA2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6N0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6N0"/>
    <dbReference type="OrthoDB" id="10262320at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043325">
        <property type="term" value="F:phosphatidylinositol-3,4-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080025">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17007">
        <property type="entry name" value="ANTH_N_Sla2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000004">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000021">
        <property type="entry name" value="Cytoskeleton assembly control protein Sla2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035964">
        <property type="entry name" value="I/LWEQ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002558">
        <property type="entry name" value="ILWEQ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030224">
        <property type="entry name" value="Sla2_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10407:SF15">
        <property type="entry name" value="HUNTINGTIN INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01608">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00307">
        <property type="entry name" value="ILWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109885">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50945">
        <property type="entry name" value="I_LWEQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="7">
        <location>
            <begin position="27"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="I/LWEQ" evidence="8">
        <location>
            <begin position="831"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="286"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="325"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="413"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1033"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU34760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU63796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1077" mass="121941" checksum="A581273F9578A5F2" modified="2019-07-31" version="1">MYSGSRTRQTDYGIDGDEVHYPTRPVDKDKAEGELVVNIKKATNPEETAPKQKHVRKCIVYTWDYHSSISFWTGLRVQPILSDEVQTFKALITVHKVLQEGHPVTIKEAHGQTGWLETCARTVGHETARGYGPLIRTYVQFLLAKLRFHRLRPEFNGLFEYEEYITLKGIDDPNEGYETISDLMGLQDQIDSFQRMIFAHFRHSASNECRISALVPLVKESWGIYRFITSMLRAMHRRTNDIEALEPLRARYSQQHYALRKFYYECSNLKYLTGLINVPKLGQEPPNLLDNGSAPDLPARPTTATVKTPPPAAPATPDGVNVAEQARMLKQYEEQQAALVAAREEEERRRRELEEQQRREFEQRQAEQAERERLAQEQLVQQQMQQQMMQYSNQAAQQMHDLERDLLAMRGQYERDQLMLEQYDRRVKALESELSSVTTNVNSQLMSKDELIRQLQEQVAMWQKKYEALAKLYSQLRTEHLEMLSKFKQMQLKANSAQEAIDKMERMERDLKAKNLELADMIRERDRARFDLDRQKSAHKDEIDRLRREISFANERAEDATRSKSSEVSGVLAKYNRQLNELEDSLRAKQLQIDDLLSKLDHATTDLDRLREEKDQEISLLQEGMDATIQQLQEAQQNQGLNEEATNAQIDTLILDNRKKLNQIIDSILNACVAKVDEAIYELESPAQAGNLNSTPEYTLSMIEKAINNATDFATVFNLYLGGEPGGDHVDVIKGANELAQSLADVLINTKGITRLVDDEVSDKLINVAKTAGDTGLRTFLNLQSYKLDLIRQPTQRKEVAMRNNSEVRGALSKLSEVVDGLVPKGGKAGAVAKTNGDLGDLVEQEMLSAAQAIEAATARLEQLQSRQRDSSRYSAVDIQVHDAILASALAITNAIARLIQAATESQQEIVAQGKGSSTTQQFYKRNNRWTEGLISAARAVAFATNLLIESADGVLSGTHTLEQLIVASNEVAAATAQLVAASRVKANLMSKTQERLELAAKAVTEACKALVKQVKAIAAKQVQEEDVDYKNMAVLEFKRREMEQQVEILRLEKELNAARHRLGAMRRAGYHTDETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7C9</accession>
    <name>A0A4Q9P7C9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_660284</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7C9"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7C9"/>
    <dbReference type="OMA" id="HLNTTEY"/>
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        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU62950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="708" mass="79078" checksum="3D1D6F5F32D77F52" modified="2019-07-31" version="1">MVQKIREAEDVLRAIPKPGESILPVPGEENILITSALPYCNNVPHLGNIIGSTLSADVFARYSRTRNRKTLYVCGTDEYGTATETQALKEGLTPRALCDKYNAIHVETYKWFELSFDIFSRTSTQKHTEICQEIYLNLAKNNFLERAEKEQTYCEGCSKFLADRFVEGTCPHCGADDARGDQCDVCGRTLDAIELINPRCLVDKTHKVTTRTTAHMYVRLNELQPRTEEWIRKSWKKGHWSPNAVINGDGELVDARLKGGLRPSPVTRDLTWGVPVPHVDGKEHEGMESKVFYVWFDACIGYPSITANYTSEWKRWWFDNKNVNLYQFMGKDNVYFHVIYFPSIQLGDGRPWTMLHHLSTTEFLNYEGGKFSKSHNRGVFGPAARETGIPPSVWRYYLISTRPETADAMFSWADCIAANNNVLLNNFGNFVNRALKFVASQYESTIPDSGDEPGPYSPNDENDAEFITEINALVKEYVDNMDAVKLRSGLHTVMTISARGNLYLQSSGLNKQLMTENPKRCAQVVSRALNLIYLLTALVHPFMPSTEAAILAQLNAPPRAVSTVLSNDLLAGHTIGTPEHLFKRIDEKMADVWRDKFGGNKPQEPSPLAEAADATHVVPGMSKRKAAAAKKAADKAAAAEATANAPPKSSEVLAWEQKIAQQGQVVRELKAKPKSEENDKEVAAAVDELKRLKAELAELSQKAQTPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7F3</accession>
    <name>A0A4Q9P7F3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein S-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_662443</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU62984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9017" checksum="F240B3A30F5A5973" modified="2019-07-31" version="1">MTNTSVHNAALNKQFGLVRSLVSQDPKLVNAIDDDGRTPLHWAASSGSVDIVRYLIDQKADVNRGDSGGWTPLHIACVYPRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAJ5</accession>
    <name>A0A4Q9PAJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_324989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145294">
        <property type="protein sequence ID" value="TBU51684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAJ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7648" checksum="4DF89C6B433B13EC" modified="2019-07-31" version="1">MVWLDDARGSQISPAGCTCLLLLGLFATGGAGNTSRSPARGGCISDRRLQTAAPLLYYLALTSQIHTRRVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAJ6</accession>
    <name>A0A4Q9PAJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_983062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145480">
        <property type="protein sequence ID" value="TBU50985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAJ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="309" mass="33544" checksum="FE5BC96386A36F93" modified="2019-07-31" version="1">MATLESLEPRLYLLTETRSKHFGSAEDVRAVTLFVNGVSATFNVLLPTAEILLAITPETEILQWIELAEGDTLRACDISDAQRDIVLKILYAYRACYFQHGVTPADIELFFRLVAEAAMALDDHEPADEVLEDLVQYVTSAFPSDCLATLPTTLHPPHPPVTCTSPPPVTCVSLPSDASSVAAPLGRPAPAPTVAGMRVRPPRPLPKRSHTVPPVSPVHHSPTTLPSLASVLSPSAVAAERTFGDCTPAHVSVSQDDDSWPSDDSVPDLESIAGSESDSEDPYNFRQHLSFEELVNLDMQDFLSRLSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAM5</accession>
    <name>A0A4Q9PAM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_789749</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145445">
        <property type="protein sequence ID" value="TBU51015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAM5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAM5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="397" mass="45887" checksum="2335AF77DD72A3B7" modified="2019-07-31" version="1" fragment="single">MEWQYSGSMTKSAGELQRLVDDVILDEKFNKDDLLGFNITREQRRMDDFQATSGAFSPKDGWREASVRLHLPKPGVEHEDETHAPAFIVDKIWIRSPLEVLKAGFRDITARKYHWFPHRLFRQRATPDNPTAKPERLVTDLYNSDAMIRDHEELQKRPRNPDDAADIEYVVGGVMVYSDSTHLTNFGSASLWPIYAFFGNLSKYLRLKPSMFATHHLAYVPSLPANLLRYYEDTFGVPANAAVIRLLKYDLMQKVWLLLLDQEFMHAFEHGVLILCGDGITRRVFPRIYMYLADYPEKCLLACLKTLARCACPDCTTDKCNFWKMGMKKDMADREKNTRKDTTTLQDTIARVRRWIFEDGTAPDGQHIKKTKLGFFSMAPVRSAFSQRFAAFGRNVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBT1</accession>
    <name>A0A4Q9PBT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_809931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBT1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBT1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="751" mass="81687" checksum="7C251707314D504E" modified="2019-07-31" version="1">MALQPIPSPSSGDSHSPSPELPSDGTSANASPVTSATPLYAPPPASDEGDSPQDRSTRSTPTRAMSDLTRSSSAGKGGCWTCRVRRKKCDEEREGDSCKTCLRLRIKCLGWGPKRPDWMRDKEKVAAYKASIKEQLSRMGLIRGQPRQPWHSAGLSASSQPATPGVAGPGPQTTLRRTMSARETTFRRDSYIGTGGSAPYHIPGMSRPISDADQWGHNVSASSSRHHPSASPMASLLHNHSTPNINESLYGFPSPPMPMGAGDDIPYTGFLPQQGMSISMPPPMPAPPAPTVRRDEYISYYFKYVRELQYVFAGESLTNLLLPIVQADPDGAVALSLCALAALHHGRAQMARSTQPILEDPDAENSLPRQFYNRALYLLMHSPQTNGTGQYSDSDAVTACQLIAYSLLGGGSTDWATPLDYACEWLAQTGIYNEENPKLALLNMSPAGRFAAKATMYADIFSSITLMQPPRFLSLYKRLFGGGAGFWPINTSPTAHAQHSELRMDTLSGCPDEALLAIAEISALAHWKATELQSGSLSMRELIRRGDAIEKELRERAMGKSGDIEDLKTPTVASSSSLAGGLDMPAGLAMASSSSLMSSPQPGMSGASKSTRSPVDSTKHIIGEMYREAALLYLHTVLSDSSPGVPEIATSVDQMAKLLNELPPSRYDRALIFPLFLTGCLTDNQMMREVIKHRFFMQDATNGNILLAQTVMDEVWIQRANAIRMTRQGEHPRLTDWRQSLRLQWASLFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDJ8</accession>
    <name>A0A4Q9PDJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotide-sugar transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_803799</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDJ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDJ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="456" mass="49038" checksum="C6C68E33C6010FF7" modified="2019-07-31" version="1">MPLKYVSLVTLAVQNAALSIVMHYSRVSMPAAQSYSPATAVLLNEILKGSISFVIAFLRVVYASDASGLGPAGWFFAFRRVCHEIFSPDCWKLSIPALLYVVQNTLQFVAISNLPVATFQVTYQMKILTTAAFSVALLRKRLSSSKWISLFLLAIGVGIVQLQTLATRAVPANTPVGSAHDSAPLHIHIMSPLKGFGAVTAACFTSGLAGVYFEMVLKNSKADLWVRNVQLSLFSLPPAIFPIFFETHHPAHGGILANLLRHFGGWAWATVTIQVFGGLITAIVIKYSDNILKGFATSLSIVLSFLASVVLFGFHITPTFVTGSTVVLVATWMYNQPPGKELVSITSVIPAKTGTSSFPGTPVTRDAPILGQFPSEKKRTSPFGSPRVFASALGLGEKPESGSERFGETLDTTRYLNAPYGSPFPSRTPSPIPTPPYPPPANPSSSFGSQNSGRWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDV0</accession>
    <name>A0A4Q9PDV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="5">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_182684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="5"/>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDV0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044638">
        <property type="entry name" value="ALDH7A1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43521:SF1">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="150"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU53050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="298" mass="31377" checksum="B41743C56EDC9D90" modified="2019-07-31" version="1">MSSRWVSSVQVGSVKRDSHPVLGDTQATPAEVHRALQQSRGIHGQKGRPHTEADPGVTSGQEECLGRPRVLVDWEDPDRGEGKVMLQSGSWCSIVSCDETSSRSILDVPTHLQWLCCLRRTSLWRSTAVTSSSRYKLRGSSLFASFRITDLALSLAAGNATTWKLAPSAPLCSIAVIKIVAEVLKRNGMRGAVAGLVLGWRAVGGYVDGSFDVDVVSSTCSEAVGRGMSKTVQGCFGKVLLELGGNNAAVVMPSADLNIVLPAVLLGPIGTAGQHCTIMTGGAPYSDLASPLSRSCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEB8</accession>
    <name>A0A4Q9PEB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Efflux transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_940253</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEB8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEB8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU52455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="569" mass="60406" checksum="FE830DD147A8F839" modified="2019-07-31" version="1">MSVHSDTNPTSPRSLVEKPRARENDTLSPTNMLKDSQHPHARRSMSKDIILIATVTLAMLLNTANLGAAAISLPTIGRDLNIPEAKLQWIISAYSLSSGCLLLFLGRLADLFGRKIVFIGGCACMAIFGLGCGFAQNSITIYILRGLQGLGPAASVPAALGILAHTFPPSPIRSIAFATFSAGAPVGAAVGLAIGGVLTQLTAQSWRSTFWFLTGLSALCCLGGLVSIETDVPYTLPDKRIDWLGAFLITAGLVFVVFALSDGPIAPDGWKTGYIIALLIVGVFLIVLFVLWERLLERLHTQGGEASQRWWTPPPLMPVSIWGRANGKLAAMLIIAFVSWCSFNSFTFWVQLYYQDYVGLSPILTMVRLLPMAITGVLCNVIIAVVVGRAPLVFLVGVGTLLTGTANLLFAVIVPSAPYWAFGFPAAIIGVFGADFVFSTGTLFIARVCLPHEQSVGGALFQTLTQLGTAFGLAIGTVVFNATQKNKAESSGVTLNQGGTNAPKSAQLTAYKDAMWSGFAFGLFGFLLTVLFLRGVGPVGHRKADSDDESEKTALEPADRGSGAINMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF33</accession>
    <name>A0A4Q9PF33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_860148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF33"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF33"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINB"/>
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        <property type="match status" value="6"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="5"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
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        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="207"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="246" mass="26577" checksum="795D86E6D74944DA" modified="2019-07-31" version="1">MLHQFEPYDDNVSALAFSHDNEVLASGSNDQNIILWNVTSGQEIRRLEPHVAVHSLAFSPDGSKLVAGAYDGSLFVWNTATYEDPVKLSRHVAAVTFAVFSPDGRYMATGGLESECYIWDMARLKLNGLVWTVACSPDGKSVASLSSDSTFKVYDLYSVDPQLSLDGHDSMIGVVEFSPDGNYIASAALDSTMWLWKAEDGSALTTYKDHSNNVTVVVFSPDSSTLASGSHDGTVCIQPLHMPTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFF4</accession>
    <name>A0A4Q9PFF4_9APHY</name>
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        <name evidence="2" type="ORF">BD310DRAFT_941266</name>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="38431" checksum="6E47A107DDB8F5F4" modified="2019-07-31" version="1">MPGLLNFPTFPEGVPTHPLLIIDYALLEAGDEGEIDRLWQAATELGFWYLKNHGLDAEVNAMFDLGAQTFALPSEDKVPYSYQEDGSSFGYKAMGSCVIDEKGTRDTTEAMDVSQDDVLAYPIKVHQAYPVTIGAGIDSTVRPFVVKSMDINLHILSIMDGKLGLLKGTLASLCKPEDQSGSTLRLIRNPPAITPSAQTFVGAHTDFGALTILHNRLGGLQVLVPGQEDWQFVKPLEGHAICNVGDALNIFSGGIMRSNIHRVVPPPKEQAKLERWSLVFFTRPSYNTPMKALTEHSAIVAEAVVKAPAGKFDSGVTAGEWLARRIRGTRAAQYKDSETFRADFRGTEDIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFX1</accession>
    <name>A0A4Q9PFX1_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145269">
        <property type="protein sequence ID" value="TBU52047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFX1"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6643" checksum="EB7A5D110003E0E6" modified="2019-07-31" version="1">MPLLQGRLGGGGGVEVDEQGIGAEAGASRSGVPQPDEDALLPMQFSAGPTGPLEFRDNVDGCLAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG18</accession>
    <name>A0A4Q9PG18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_941368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145279">
        <property type="protein sequence ID" value="TBU51891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG18"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020505057" evidence="2">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5212" checksum="8E6F589F50455D52" modified="2019-07-31" version="1">MQAFTKLFAIAALLFAVASALPTADISDDSINGCPPQGNDVEANPNPGSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH96</accession>
    <name>A0A4Q9PH96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_258805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145264">
        <property type="protein sequence ID" value="TBU52156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15559" checksum="F8CFB071786B05D1" modified="2019-07-31" version="1">MRSAVRRWESLHGRACMLQSEILTAVVEGEVQIWVLTADSRASDMERGDVAVPDDGRRGETVSLPGANKRAASRNEPDRTLPLFFATTSDASSPVLVLVVMHCAWTDLSSYSHESCATVACRLTHPFTSPSPHMPALVILPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHT7</accession>
    <name>A0A4Q9PHT7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_937899</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHT7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="ZnF_C2H2-type_TF"/>
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        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
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        <location>
            <begin position="2"/>
            <end position="27"/>
        </location>
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            <begin position="28"/>
            <end position="54"/>
        </location>
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    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU53517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="242" mass="27599" checksum="8B8265B615154ADC" modified="2019-07-31" version="1">MVYCERCGRSFVTEHALRQHQRYSSNHHLCDACDRDFVSEAALKQHHMNSSRHTYCTICEELIDNLGISLQEHREKTHHACPGCDRVFEDRRSMLAHCEQAHADRWCSECEQMFKNENNLRQHLHSSTHRPANLPCPMEDCERSFIGPAALVLHYEGGACPSGLTRCTVLRAVARYDKQGVITTNDNRCYCPEAYGGCGQEYTLVSALFQHIEHGRCGLDRSARKLKKVLDGVTKGRFVTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ10</accession>
    <name>A0A4Q9PJ10_9APHY</name>
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            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BD310DRAFT_936805</name>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
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    </dbReference>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU54069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="439" mass="47689" checksum="CAF2AF7A91AF5653" modified="2019-07-31" version="1">MQLQYWFALAVALTPSLSSAAIFPKDTLVKMIDAKGFKDAMKANATSLVAFVAPWCGHCQRMAPEYSKAALGLYPMIPFYAVDCDKASNKKFCADQGVQGFPTVKLFPRGGKSKPVLFDGPNRSASAFYYWALRNIPHKVKKVYHLEDLPAWIEENKELPRAVLLNQGKDVPLLWQTLDNKYQGQIKFAVHRDRRGKSSLKMGLEQGEPKSSKVLLYPAGSTEYVRYEGIQKHDSLSKFFDSVLDGTADLTTLNKQAAEEEFVPDEALLEIERKQEAQRMALAHGGFSNLIDFEEAIKNGAGADYHSKNGFPGMMGGSLPKKEKESGKAKAEEDPIRKILKAQQEAEKSERGKPKMAKTDDAGQVVFTPQSTGHPKTPAAGETTTGSEATVAESASSTLETLSAPADEASSTTSDTARGAATSSAVGETRAGGHATDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJA7</accession>
    <name>A0A4Q9PJA7_9APHY</name>
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        </submittedName>
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            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJA7"/>
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    </dbReference>
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            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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            <end position="122"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
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            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="498" mass="54918" checksum="9C3E5EB42632978B" modified="2019-07-31" version="1">MWLQRRGALSQHHHVMGGDRKGGRRLASPALRLPPPRHPNHHSTSGCKSICPSMHPAQMLQAMQDVARGKKVPSFMTRLKKFRAGYKVRSNPAPVPHDNRAAGTTLEPDDQKNTQQSLQTIAPNPHSRPQRPRIRIPLIARNSSPSTETCVHDGGCESPLESYPTTLVGSPASWSPKTASRSSLLTLDSPEEKKALQPPTSPEDLEASEEDDGARDERQWRDERSRPIARNDHGEGAPSCVTNPRPSPLSLVDLAPSSTPPRPAPLHALQGALGETVWYMIGSQLDQHDLTRFAMICSETLLAAESLIHRHPAIRDEDTMVAWAAALERNSDRAHLVQSLTVGWDTEEDVKGDAAIAFAAAIELLRASKNLHTLNVFATATAGNFGSGHILPASVRTLNTSGAFFSRVEQPLPFLRHLSIRVEANDLNKLRTPISLCRETLIQLRICLKWPSPMRKREDNPVRLCSHLDAPNLVYLELHEERSEDAESPVFGLEARVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJY4</accession>
    <name>A0A4Q9PJY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_886212</name>
        <name evidence="1" type="ORF">BD311DRAFT_866759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143445">
        <property type="protein sequence ID" value="TBU26464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU54439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJY4"/>
    <dbReference type="OrthoDB" id="3006153at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU26464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19395" checksum="F11A976C64FD135F" modified="2019-07-31" version="1">MTSTSISAEGWHTRAVPHPDHDALTFQPTIDNLLFTHRFSAMCAEGFVMALFLPDIAVDSDGNVLKVQPQDFVILATLVKDVARLPDGGPFNGVWCLSSTYTCQARDHLNVKTPEGTLKQSGVYAWSPRNTALAAPTAGYEHLPSSLHELVGYSWEAYAGGSREKKPSPLVDVITSLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKE0</accession>
    <name>A0A4Q9PKE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PPPDE putative peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_935360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145184">
        <property type="protein sequence ID" value="TBU54619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKE0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKE0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="7">
        <location>
            <begin position="2"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="195"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="6">
        <location>
            <begin position="343"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU54619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="668" mass="71313" checksum="3FE325531785CC35" modified="2019-07-31" version="1">MSKVQLYVYDLSNGLAKQLSRQLTGRQIDGIWHTSVVVFGKEVFYGQGILITAPGQSHHGRPLQVVDMGETAIDEETFDEYLNEISSHYTADKYHLLDFNCNSFTNDCVGFLTGGSIPSWIKDLPSDFLSTPFGAALRPTIDAMFRRPFPGAAPTPPPAPNAAALQQAASASPNPALASALLQAVASQAQSTGSLSAPTSLPRAPVPGSSTVAAPIHICTNSSSLHGLLQSHRAAVVYFTSATCGPCKMIEPVFEELAHQKTHGVDGARLAFVKVDMAMGSGGQAGAEWGVRVTPTFLFFLEGKKQHELKGVNAPELRTQVDLLLYQAFPPHPHTKLSLPAVEALSMNPILFQQIPPLDTVSAKLVASIDAASSSADLQTAKQAIVSAVLPYLKSRFQEKSAEAKKPAIPATPQLLTSFTTATKSLVNALPPVQLFPLVDMWRLAVVDDSIVANWLATTTNPDALQALLDKALEALDSSDPAQKSSGRNYILTVLRLLANGFAHPTLSRGLLSRAPPAGKRPQVTRIVVSTLLHEDAAVRTAAASLTFNVAAALQKSRVEKLRGPTAGAVPVAVEEDEEWEAELASAVLEALSNEVQSEEVVHRLVAALAFLLRLSPSYEGQLGPLLEVLQARDTLKSKLEKGGCGENGVQKPEVRKLVEEVATKLCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKP3</accession>
    <name>A0A4Q9PKP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_935243</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKP3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKP3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU54666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="197" mass="21658" checksum="D4D90E4A288B49B6" modified="2019-07-31" version="1">MSRRSFPGGKLDETDSTPLAAALRETREEVGIHSNQIEILGRLAPPENSLSGMRVWPYVGFVYPPETRFDKESDTHNSNAHNAAPLPSLPLSSLTLSRQEVAHVFHLPLAAAVSPTRLHSYLFRGARPYHAVSVADLIAGPGAVHSDQGPGDQAEVRWIVDPEQRDEVGGGREGRLEVWGLTGWYLNVFLRTLGVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLG9</accession>
    <name>A0A4Q9PLG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral peroxisomal membrane peroxin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_934530</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLG9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLG9"/>
    <dbReference type="OMA" id="PPFYILT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006614">
        <property type="entry name" value="Peroxin/Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052646">
        <property type="entry name" value="Peroxisomal_PEX28-32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010482">
        <property type="entry name" value="TECPR1-like_DysF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31679:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06398">
        <property type="entry name" value="Pex24p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00693">
        <property type="entry name" value="DysFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Peroxin/Ferlin" evidence="7">
        <location>
            <begin position="245"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="328"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="495"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="570" mass="62567" checksum="A4DE980B7FE2B732" modified="2019-07-31" version="1">MSRTADETTHAQSTPLVEFLNTLPSPVTTALVGLAPVISRSRYLAQLLVWKAAWEDCWLFLASWWAICLVPELGLRYLLPLAVLLVYFRPRGDPNIQRSPPTITEDTLQRAITDLTTIHALLPSLPLPVPSKPLTVPKPLVLLRSIAVLYIPYFALTYVVRIRILLALFGTLFLTWRARWAVVLRGALWRSAHIRWAVYRLWSFLSGQSLPPLTRSPQAQSEARLASVSSPSSLQAQKKPLPDTNVRFLFTIYENQRWWMGLDWTAALLPGERPSWCSASQQPAAPPSAFTLPAPTTAYTPTADGKGRVKRVARWRWEEDEWRVVVRREGSGTSRVERPVPSAKEESAAAASANRILKAAGKMRSGSLDLMEKGTEKERDAQANSGEGHGYSGEHGTSPNDSAHDAKDEVEVEEPFTDADGWVYADNKWEGASSKGGMGKYTRYRRWTRIAVLTETVEIVGPGELGIRRDELPAPALEASAPSLVIPSLSQTVAAGPRTPLKEPADNSNNTASRPGHSRSSSSTASWPPAEAISRETVTVTPASSPAVDDSASRLRQRLKAAVLGTGDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMK5</accession>
    <name>A0A4Q9PMK5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Lysozyme</fullName>
            <ecNumber evidence="11">3.2.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_933912</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">This enzyme has both lysozyme (acetylmuramidase) and diacetylmuramidase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Hydrolysis of (1-&gt;4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the glycosyl hydrolase 25 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.17" evidence="11"/>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMK5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003796">
        <property type="term" value="F:lysozyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016998">
        <property type="term" value="P:cell wall macromolecule catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042742">
        <property type="term" value="P:defense response to bacterium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031640">
        <property type="term" value="P:killing of cells of another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06412">
        <property type="entry name" value="GH25_CH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000060">
        <property type="entry name" value="Lysozyme M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002053">
        <property type="entry name" value="Glyco_hydro_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008270">
        <property type="entry name" value="Glyco_hydro_25_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018077">
        <property type="entry name" value="Glyco_hydro_fam25_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34135:SF2">
        <property type="entry name" value="LYSOZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01183">
        <property type="entry name" value="Glyco_hydro_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00641">
        <property type="entry name" value="Glyco_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00953">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51904">
        <property type="entry name" value="GLYCOSYL_HYDROL_F25_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="6" id="KW-0081">Bacteriolytic enzyme</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 11 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020251983" description="Lysozyme" evidence="12">
        <location>
            <begin position="19"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU55374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="233" mass="24877" checksum="C7F3CAD01B603A3D" modified="2019-07-31" version="1">MKFATASVFVLVATAATALPVLQKRANPKGIDISSYQGTVNFNTVKANGISFVYIKATEGTTFKDPNFSSHYEGATNASLIRGGYHFAHPDSSSGATQAKYFLAHGGGWSSDGITLPGALDIEYNPSGAECYGLSASEMVSWIKDFSNTYHSSTGVYPVIYTTTDWWKTCTGNSAAFASTNPLWIARYSSSIGALPAGWSYTTFWQYADSGSNPGDQDEFNGTLDGLKKLALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMP6</accession>
    <name>A0A4Q9PMP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_856601</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMP6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMP6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="109"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="184"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="120"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU55523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="563" mass="64752" checksum="49ED2CB77FF18003" modified="2019-07-31" version="1">MRFAAPRSPSPSPTRNRRHRPRSTFAVPSESSSEDEDDASGSESASSSEGEWLNHRPEPPKPRREKSLAEQWAREDTLAAVRRRINYHDPYEEWEKETRQEAFRVARQKHTQDCIQQRNARNERRAQDEQRSAALHEQQLKEVESQLAAMNLQKQQEEAMLRAQWKERDRQLWARIDAVIKQEEERRRVEQEAERKKREEEERLRREAEEKKRQEEERKRKEEEEKRKQKEKEDEERRIKLAAAQAEKEREQAETEARKALGHSTAFEDWRRGRDTLRTLKAGPMKTVKQNKEMKAIWSAGRRAITPKVGQLTSDMAVVVRVSHELVNILRPPQAHPPPIYIALLSSLAKAILMQAETEVTAEKKSAMPLAQLTVNLLTSLEGFADIFWAKLCQRAGGWPVPIAIPANDTDGTTITPQSMRKVQGFRDTDEGSEVLGDYTSRVTGILRVYFTTLVLPVNQPLDPMFRMDRYWTYFTRMLKDPQLLESPVAAQIMFTALDIGGLHACAVWGSQWTRLLALLFEGVTVGYHGLEGRLIGGKAPEGNASRTRLQLEVERIMAAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN75</accession>
    <name>A0A4Q9PN75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_979477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN75"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="15"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="267" mass="28807" checksum="2119B0CC76FE7A35" modified="2019-07-31" version="1">MTDLVGLDDNGNTQYMVNITLGGEEFTVVLDTGSTDLWVDVRDRNIKLTNSTNITAEEGYALGSAAGTINFAELRVGDYLVPSQAFVAVIQTEDQSVQGMLGMAFDDTSIYEALAQAWGKEAANELGRAFITNLFAQTSPFPTTLTSSSAEKRLTTRLFVFNKSIVSGVPNGKVLAVLDSGFTLPPLPAAAVNAIYSQIPGAVLYNTTSGALNGWIDPCEFAPVNVSFTFAGQEYPIHPLDLFIPWYPTLIIDNGIEKNVTLYKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNP8</accession>
    <name>A0A4Q9PNP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_932892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNP8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0371">Homeobox</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="2">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11902" checksum="AE02EB86CC66096B" modified="2019-07-31" version="1">MPGLVTGMVSPDCDQIPHHDTQQLFDVDRIEDPGASLFVIPAVYKTESTVRLTDIDVRHLESSYQHDPYPSEGEVRRLRKELALSVDQLRRWCVVCDETLQSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP29</accession>
    <name>A0A4Q9PP29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aryl-alcohol dehydrogenase [NADP+]</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_907982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP29"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="33"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="44403" checksum="BE160E32C3363DA3" modified="2019-07-31" version="1">MSAAHLWAPAGAPPTKLGRHRRLSDKAGVHVSPICLGGMSIGDKWASYGMGVMDKQSSFKLLDAFYEAGGNFIDTANNYQDESSEAFIGEWMETRGIRDQIIIATKYSTNYKRGRQDVKQHSAYVGNHMKSLHVSVEDSLKKLRTSYIDILYVHWWDWQTSVEEVMNGLHALVLAGKVLYLGISDAPSWIVSRANQYARDHGKTPFCIYQGLWSVMHRDLERDILPMVKAEGMALAPWNVLASGKIRTDEEERQRRETGEKGRTVLSPNWERTEDERKVVKVLEEVAAQVGAKTVQAVAIAYVMQKIPYVFPIVGGRKVEHLYANLEALDIVLTGEHIRKIEGAVPFRAGFPYDMIGDGTSYNVGYANAGQYDLWPEREAIRPNQQNSGNAVMPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQA2</accession>
    <name>A0A4Q9PQA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_931501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQA2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQA2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="41"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="237" mass="26760" checksum="F58994A7D14E604B" modified="2019-07-31" version="1">MQIDCVMHKHLSLLRLSGASHARYASTSAGSYPFPAHAHPTPHQIFHLPLGASQKEIKARYYDLVRVHHPDAPCVRDLSPAIRRSRFQAITAAYDILRGKKSGSFGGTGDIYRDELLRRKRAWAAHEQSRRRSGPLWEETPARGWTASADDRWKDRVILFVGILALGAGLGPALIWPSYTASQQAHLSASRNLAQARKEAREFGEERRKEISRRVQEYKEKQAKERPPEEVMSSSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRJ7</accession>
    <name>A0A4Q9PRJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRJ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8181" checksum="7295415C1D5A7C31" modified="2019-07-31" version="1">MGKIWVALQRVSDSSAGRDRLLVAITTIRLVTHSNLLSALRRFHSRTRCLSAQAVMRKLRWHDRTIPPLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRP5</accession>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9979" checksum="96C1E3BD356B8157" modified="2019-07-31" version="1">MRACTRIYALHAVGIVLGTGDCIYVCDRRAANASITTADALREKNGERARLGRITALRRDRYWKGKITRKPRREKRRMNAMIERMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS89</accession>
    <name>A0A4Q9PS89_9APHY</name>
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            <fullName evidence="2">Pex19-domain-containing protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_929706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PS89"/>
    <dbReference type="OMA" id="EMLYEPL"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="GO" id="GO:0005778">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="343" mass="37039" checksum="10A6A2CBFF320D31" modified="2019-07-31" version="1">MVAPPPRKVTVEEDDLDDLDDVLEQFSAPPKPAAQPATAPSSSSKSPPPASSKDAAAPPSTQPQPKPTDPLGMDGLDDDFARELMKGMESLFRDVAQGAGLDDVPHPEDAPEDDSPMTAEERQKVFQKAWEAMLIDSLNEQFSPEEVAALKSGGKGKEAEGPAKPVGANAGPPQSFQENIERAMHKLKESNQKADEASATGAGGLEDMFARLANMTSQDSEEEMKGMLETMMSSLMSKDVLYEPLKELHEKFPGYLKEHDATLSAEDKTRYQTQFKIVAQIVTIFEDPSYSEDDPQSGVKVVELMQEMQDHGSPPSEIMGPLPPGFELGTDGLPKLPEGCTIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSV4</accession>
    <name>A0A4Q9PSV4_9APHY</name>
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            <fullName evidence="6">Biotrophy-associated secreted protein 2</fullName>
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    </protein>
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        <name evidence="4" type="ORF">BD310DRAFT_552997</name>
        <name evidence="3" type="ORF">BD311DRAFT_269239</name>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143413">
        <property type="protein sequence ID" value="TBU29376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="OMA" id="QQFITGA"/>
    <dbReference type="OrthoDB" id="2132010at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597646" description="Biotrophy-associated secreted protein 2" evidence="2">
        <location>
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            <end position="285"/>
        </location>
    </feature>
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            <begin position="67"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU29376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="27379" checksum="CE9C8BC751BBA718" modified="2019-07-31" version="1">MKLSVLFAIVLVNFAAATYVPRAAPGTQFITGPCSGDIDCASGCCGFKSGKCAGAIVAQERDGGCGFGDPQPNDNAARKLRGEAPASSAPAVSTSSSSAVSASSAPAAVSTVSSAPTTPAPSVAPGSQFITGPCTSDADCASGCCGFNTGKCAGAIVAQERDGGCGFGDAQPNDNAARKLRGEAPASSSAPVASSSSASAASVSSTAVVPSASSVAPTTPAPSVAPGSQFITGPCTSDADCASGCCGFKSGKCAGAIVAQERDGGCGFGDAQPNDNAARKLRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A4Q9PTD5_9APHY</name>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTD5"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11823" checksum="95A956C008FF0405" modified="2019-07-31" version="1">MPTLDQLPTIPTLEQLQKMASALRQLRGKVPAGEQLPESTLEKIKKKVLERSASLWTSASQLASEGAEAAAPVVSSVIDRTLRSEEVAKGAEQIGGLMRQVWGSLGTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTX9</accession>
    <name>A0A4Q9PTX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTX9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16251" checksum="1D215F9EF4B2844C" modified="2019-07-31" version="1">MTLTCCTVIIGHPRMRTRNLSWSQSLPLRLALSIHTAGTCIRHYQDAVLGSIGPNSSPVAGDIERCREYVTLKTVYVSHPERASTVRLRSQSTTRDKQYIAGEEDPRRSTCAKVYRGTLRSRRGPPDCSLGSCSPARTTASPSCTSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVV2</accession>
    <name>A0A4Q9PVV2_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_906448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVV2"/>
    <dbReference type="Proteomes" id="UP000292082">
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        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="144" mass="16210" checksum="891E896E8E640115" modified="2019-07-31" version="1" fragment="single">KFGYMAREYRTYCKEQAVQVGQAGEGGADDEDAFGPDRGEDEDAVEGETEAARLQCSIRRTRAVTVAMQRERKAKGTAWDDPRYAGAFLVNAQSDYEDEFKEGDRPAGVPVKSQNQSRQVCFNGEIQESRGRWQRGHDIVNRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW61</accession>
    <name>A0A4Q9PW61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_438828</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0004672">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="311"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="806" mass="90602" checksum="00135043997CCFEB" modified="2019-07-31" version="1">MAHNGVPAELIEFCDEFFPQPTQIATVKPKPTLDDNPFAALKDAEKLSEKTVRAAFAVAINVHGLAPGFKVAECGDRPDPATIDPERKKIDVAFYRVDDVQDDGRQRWADQVLPVAFKCDDVSLDPFDDNEGTMCTPTMTHRAIRGQIMSHAELIFAVQQRVALFTLVVLGNRIRFVRWDRSGTVVTRAFDYIQNWEVFCDILWRIGNCTMTQLGFDPSATRLHPGQTEYALMDAAADNVEGDFDETERVISGPKLPDGHFKYVREMFKKSLVDGWPRYRLEVPALVEAAATATTATPAHHSDSSPKVDRSARKFLVCKPEFRACGIAGRGTRGYLALDCATKRFVWLKDAWRANYEKMDQEGVMLGSLNSAEVPFVPTLLCHGDILQQTTVTPDWWERKNPLRSPTSSSDTASSHTLVVPLRSGILKRKRAEESCGDPPAPPHNTDGDSDEGEDWRTDCPLRLHMHYRVAMKEVAMPLSKFRHDRQLVGIFYDCLHAHKSAVERTKLVHRDVSPGNILIYPKVIKMRGKYWLRWSGLLADWELSRAVHEPGTSRLPRQPERMGTWQFMSVAVLSYGLNIVGVADELESFFHVLLYAAVRYLKVQNCDRPTIANYLYTYFDLHGVDDEVYVCGDKKRETVTEGRLTVSFNKKLHFDSPLDILFSQLLSGFKARYAILAKEVKATPATSPVKSETLAPSNDNGALLDEMDLMESDADDSESDGFSDDNEELDVSPQTRDLAEKVSTHEHVVRAFLKAYVSDGWHGARVEDNIPDWWAFQEQAILAVTKTSVASNKRRKVGPPPPDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWB7</accession>
    <name>A0A4Q9PWB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_440458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10888" checksum="E6268395C9CE4293" modified="2019-07-31" version="1" fragment="single">NRQVHKLRQLAADAALRASVSSSVGPSPKRRASSDDPRLNGFVLVSCAYRIRRSCIVQSRHPRNVCVVRPRMIASLTCMRTTPRRLPHQAYLPRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX48</accession>
    <name>A0A4Q9PX48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_877231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13371" checksum="A229CC6A4A14AA46" modified="2019-07-31" version="1">MPQLCSSTWPRDGSRRRVTSRRTQRRDHQPRPTGPASLPASSRPLCRRTHTCSPGKPHATRTAPSPSPRQAGRAYFPATNAAAVPCISPCMSPKHLQTSRDPGKSVRLTYLAVIHVTAAADPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYE8</accession>
    <name>A0A4Q9PYE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_373475</name>
        <name evidence="1" type="ORF">BD311DRAFT_819097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143505">
        <property type="protein sequence ID" value="TBU23438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYE8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU23438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="6048" checksum="08C288F93FA45BBE" modified="2019-07-31" version="1">MIQTSDQYQVFAGCVDTVVSFAYSFSVCLVVHRHSQWRSLPTATLRSSLKISPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYV8</accession>
    <name>A0A4Q9PYV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_923640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYV8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="165"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="446" mass="50561" checksum="4E438BA9A1352360" modified="2019-07-31" version="1">MRIRQQLTPPSPQEVLLHTLTVDIIHPGFNRPLFSLPAFSDEPTPSGDTQYGVDHRLVLDACRILTNLTANDQDGYIAHDCAGEQRVSLDISLLSPGRYFYHLASPGTTSKYRIVKDFSAWRLPASIPSHWVRTRTPEERSALYRYEFNSASAMSRVVVSEDGHCVITQYQQSCENAHLVPKEHEDWFNGNNMTDYNLSGPLTGLDDVANGLTLRSDVHQCLDRHGFVFYPVEGNRFVAYVVRRGAFEHAELFHQRLVTLPNRVSDQFVYARFAYTFINLPRDKDAFDVFPVSEEVERRRAARLAVRKMPKEAGRQKRSKLEVIHGGADIITSEMSEGSRGNSGTDAETVDSEDSMLQPMTEISYAAADKKYRDRFLKRFPDQAEEVDNPPESLVTSCHTDTPRMLRLMSEYMKKNPQVWKTSSTPAEATRPDVEGYYADLLAGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZB5</accession>
    <name>A0A4Q9PZB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_816096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZB5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5287" checksum="CAD65062330ACF25" modified="2019-07-31" version="1">MSMVPAGVNICQATFWFGVTGKIICPIGCTQFNNTSVALSETSVKSFKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZW3</accession>
    <name>A0A4Q9PZW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_338513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="101" mass="10013" checksum="0259EDC47D002FDA" modified="2019-07-31" version="1">MRFTAVASIVLAASSVGLVNAATLEQRQLGSCSTSVLGDLKLPLCGAIFGDCTGDGCECTELTTAVVDSVPGLSSILSMLNITGTLDLGDLGLCTSGDSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q161</accession>
    <name>A0A4Q9Q161_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_267077</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q161"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12124" checksum="1C4A6388E1A98AC1" modified="2019-07-31" version="1">MISPALYRRASEITAVLSRTFQSQGSRLFPQRLEECKGASRCARATCHVPNLATWASLRRRLEQGGQHNLVSLVRLPRSFIVSLAIHGCSIRSLLYSSSANLQPFPVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1V4</accession>
    <name>A0A4Q9Q1V4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_213178</name>
        <name evidence="18" type="ORF">BD311DRAFT_664872</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
            <strain evidence="18">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="ML143429">
        <property type="protein sequence ID" value="TBU27749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1V4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1V4"/>
    <dbReference type="OMA" id="KNVTPRL"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="242"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="681"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="706"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="342"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="411"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="480"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU27749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU61193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="750" mass="86005" checksum="A3A3A0AB53177CBB" modified="2019-07-31" version="1">MSGNVRARRQASPPGRHTLPVQTSQRFPHPRHDHLDADERREAASRGLRPGRKSHAVGGLNLSPGEWKLLAVILIVASAVRLFRISQPNSVVFDEVHFGKFASRYIKSSYFVDVHPPLAKLLITLAGWLFGYDGNFDFKDIAKVYENVPYVAMRMVPALMGVGTVPLAYLTIRALDCRVTTALLASLFITFENGMITQSRHILLDSPLIFFTALTTFAWTAFCNEDHYEPFTESWWIWLSMTGLSLGAVVSCKWVGLFTIATVGLGTLKQLWDLLGDLRVTPKLFIRHFVARAICLILIPIIFYMSTFGIHFLILSNHGEGDGFMSSEFQHTLNGRGMADTFADVAVGSQITLRHVNTQGGYLHSHPHLYPGGSKQQQVTLYPHRDNNNDWRIVNATADGDPYTNWMDHDISYITSGTRVKIRHIQTEKSLHSHDVRPPVSDVDFQQEVSGYGIPGYAGDTNDDWIVEIYKGDKRDKESGKRLRTLRTQFRLKHVMTGCYLFSHKVKLPEWGFEQQEVTCNKQAVLANSLWYVETNYHPKLPEDAPKVNYKLPGFFSKFLELQQVMWTTNAGLTDRHMYDSRPDAWPRLRRGINFWVKDHRQIYLLGNPLIWYLSTAAVFAYAAVRGFLILRAKRGFRDFENTRVAKYDAICGFLFVGWALHYLPFYIMRRQLFLHHYFPALYFAILLSCSVFDLVTFALRPRARLQIAAVLLVVAIWNYTYFSPLAYGLPWTKSKCYKAKWLKTWDFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1Z0</accession>
    <name>A0A4Q9Q1Z0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1037830</name>
        <name evidence="6" type="ORF">BD311DRAFT_805424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU60594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="200" mass="22455" checksum="9F34503404E785A8" modified="2019-07-31" version="1">MSLINHPCIICCRPTSMWCSRCQNAWYCSPEHLQSDWPRHRRECIPTNAPQPQYPNMIATPPPAQAELVSVSALLFMPHEDRVKVTTVQCRPQGTISQGMCPTPLVQDWFTESVPNTIILTQGLNGEPLRFPLHIWYCPTSLQRGSPVNRAIYRITSGAAQKPWCGPVIVLKFNGSRRQGYADAGTNDLPALSAYFLAYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2B8</accession>
    <name>A0A4Q9Q2B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_921622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2B8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="438"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
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        <location>
            <begin position="285"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="504"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="543" mass="56168" checksum="340BCD45B2F07A50" modified="2019-07-31" version="1">MSSPVPPSPSVSIPGPRPLQLVDGNLQYPAESPCPSPAVSGLSTPPPSARKFSSRRQSSIAYYPSDHTPSWEVRSPTATAAGPSSLRRTASLSQNVPARLNLKRDRRSLPMAEVEAVGSPLTERPPLTLTEKHADLLRFIAQKESKCLELRSQLAAHEAELAELKRKWERIVSRGMDRAYSQQLTHPGSSSLLSGAVKDVSRLLAAGLSDLSTSPAPASPRLSSKANRASWHANTQSVSSTATSATSASLTSSSVRLSQSSASSFAYDDVPEEDEREGAPGSLPSSDHSASLRRSSSSVRVDGGTGIESPIEISSASALKAAKLHRRKSRDAPPPSSYPLASPEPDVAKADSASTRSSAKRSSLPAGSSKGAAGLPPAASIPGLGPLASPLASAWMGSVGTSVGKKWGEIQKGETFTKSQKRASVLISDAASSLFAALTSPSSSSPAPTPSGVSVMSNPFSATLSPMSTSPVSRPSPVPSASSLLDDDSDATGLGSVLVPDSKSPLLTPTLVPSPAYAAATSHSASAASKSKDLLDDDDDWNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2E6</accession>
    <name>A0A4Q9Q2E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_957372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2E6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2E6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="147"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="408" mass="45601" checksum="6D853FFA8D2977C2" modified="2019-07-31" version="1">MTMAKLLEYQPFKAVYLVYSFGTFILVKIPAWFFSYVSPSRRPRPTWTIRRSLIIRSFQELQELFTVKIHLQLSHRDPLQEVLDSSLTDAKFVWLEPIPDDSPLFCGEIRRFADITGVKPAKIAGYWFLRRGSAWNGPNAQPGEKVVLHMHGGAFCIGTAHPSDMTANISRGLLEYSGTLQRTFSVDFRLTASAPNPPANPFPAAVLDSLAAYRYLVQNCGFEPKNVVFAGDSAGGNIALALVRHLIENDLSSLPPPRALFLSSAWLDLMGSRDGPESSRVQNALSDIFSRRLPKGEFFAQYAITSLRGSLDLDVVKTNRYFSPAAVGAQPPEGSTLFKGFPETYVTTGGAERFLDDSKALVERMKADSVVVHEDFSPDAVHDFLIFNWHEPERTEVFKRVCSWIDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4S7</accession>
    <name>A0A4Q9Q4S7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_811002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4S7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4S7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="152"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="445" mass="48805" checksum="A877EA907D28E28D" modified="2019-07-31" version="1">MGDLLRLDPHPTARNAAVAKTPIKAGSTIMSVPAFSTCLLLTEKGRRCDGCYMLKSEAVELMRCSGCASSWYCGTTCQNREWRLHHRKMCKHYNAFVASGQYQALTPHDKVDALLLSQLVADPEAWGTDRLTDAGRTFLNLLKVPRLDGFVPPLCLSRAAQTAGTVALAEDLYSRFGNNNFILHSHLTSYAHGVFPLASRLLNHSCVPNAACKYMLAPSEPVRMEVVALRDINEGDEVTIPYLDPALPFQTRQDALHVNYGFECGCRLCTFERRIERVPTPPMRGAEELRTLDAALRSFSLGDISQDVQVPTVPGSFERLPAVLLPVLHESYLPALSEAFSKTSHEGPYSEAIDSGLTLLAFYVMLYPPNYPQIGMHALELATTLWNLTCTDASAMAGADEEQLKRHAKTALDFAASVLQNFGPEGDNGGPLEEVSVLTGMLAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4V7</accession>
    <name>A0A4Q9Q4V7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TBP-associated factor 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_872347</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q4V7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000011">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1258"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1651"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1761"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1132"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1220"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1355"/>
            <end position="1638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1852"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1133"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1146"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1362"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1381"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1460"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1496"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1552"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU62110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1880" mass="208824" checksum="600F852B545A563E" modified="2019-07-31" version="1">MQREHIRRGFSIYVDLTRRDVYTSHQKVVLEVDFTGKLWGYTEITVVPTSKDLKTIHLHARQCDIHSVTVASHPADFVHSDPLATLSVSDATDVHHHPELKRKVYSALQEGDEGELSIAIPKEVSLRQSGHRAANGLISEAATPEPQTPGHPSQPLFPVPEFTPILVNIGYSIKNPADGIQFVLPSESYQTRVPHVYTTPSSPDAARCWVPCVDNLWEKCTWDFEFIVPRSLEQQDVLSEDEDDTADSEYPTVVICSGELVEQVSHPYNSSKTIFVFSQPTLTSVQHIAWAAGPFHTHAIPADLSAAEDASGTTQPLMHAFCLPGHESFLTTTVSFMRSAMSFYVNEFGSYPFGSHKLVFVEELPTQRFDATTLSLVTVDLLYGDDVIDQVYETRHSLCHALACQWIGINIQQKMWSDTWLVNGLGLYITGLFMRKLFGTNEYRYRLKKDMERVIELDGGSMPPICQPQSLDPPDGTNISFINLKSPLVLHILDRRLGKSGTSLGLSRVLPKLFLSAISGEMANNLISTHSFLRMCRKVSGIDPRSFAEQWIYGSGCPTFGFSASFNRKKMAVEITMRQDAPAYKHLENNEITKMMLKPVPFFEGQMTIRIHEADGTPYEHVLDIRSPFKRYEVPFNTKYKRVRRNTKRYLARQAAAQAAAEGDADAAAAMDMVDMGFGLDIWEKEQERENWKVADWTEEDEQNMAGQTYEWIRIDADFEWIAAIAFDQKDYMWVSQLQRDRDVVAQYEAILVLSKTPNPIISSTFTKTVLVSNYYFRIRCEAAAALVTCANQRLEWLGLFHLFKLFLRYCYEPEDPKADLFSHTYVPRPNDFSDFAEYFVRKSILSAISRVRFENGKSPPVIRQFLVDQLRYNDNTTNPYADAFYICNIISALGCATVSSHPPERGEFISNDAAPAQDPQDAALLQAALSEVDRYRSMDRLIPTYHNVVTVAVIEFQMLLSLAGLVPHDPRPFFPLTREGNYIQVRIAAFDYLFLGRWYTPKIMRYILAVMASDSSRIIRRHVARSACQSLALLVSMGEMKTPKEADSLMIEEDGNGGERVKENKKSETELMIKALRKDREVGKNEAIREFLMPIALAPDTDCEVRWCLLKLADLLIRGQEETAPKVTIHLPPTPVAEAPPPLPTVKLSSKSQRSLKSGAPTPKSPLPSFTFPTKLKIMPSNTPVDTSAAPTPSTPAPPTASGRRGGGEFSVPKVPAKVAATAQKEKKIPKAVPKAQSGGMPLNDLRACRTALKKLQTHKKAAVFLQPVDPVRDRAPNYFDIIKSPMDLSTMGAKLEQGQYKDRFAFEADFRLMINNAKTYNVAGSFVHAEAVALESFFDTTWVRINKTLEAASKKEQAQPAPPSPAPPIQTPAPPPKVPKASTPTATSAATPPVPILKLKLGGGGGGPSAPNGTISSPAASKPAPKAKGKKPKEPKLSEVPPPPPVSAPDTALAPPFDDIDDGSADLLEEVIAIERQQKEKGKGHERRRTPPAPHKEKEREKPAPPPPTDKSKERSIPKLVIGKRKKEEVDTTEDEILALATPAKKERPSVPAAGSSSAPTLSVSTPKRVESPAPARNGVAAHKSKEKLSKPSPPTTDHVPTPSRVSTKGKEKEHSRPVTPANGKPKKAPTQATPLNEKKCRDILRLLAKQPEAPIFMRPVDPVADGCPTYYDEIKEPMDFGTMHTKLAEGKYATMEDFAKDVGLVFNNCRTFNPPTTYPVNCADALEKLFKKEWAKPAEKKLPPGERKQLVAMMKRLIDEPISWVFRDPVDPVALGIPTYFDVIPRKDARDLRTILSKLNQEKFESIDALEADLDLMIKNAILFNGEDSEVGDMAVKLQNRYRELLAPIRGGQANGQAKRKGVDAGKPPPTKKAKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Z8</accession>
    <name>A0A4Q9Q4Z8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="3">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_871142</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(2R)-2-phosphoglycerate = phosphoenolpyruvate + H2O</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="3"/>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Z8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4Z8"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.10:FF:000001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="11">
        <location>
            <begin position="143"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU62422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="442" mass="47171" checksum="920D02E58F38F82F" modified="2019-07-31" version="1">MSITKIHARQIFDSRGNPTVEVDLYTAKGRFRASVPSGASTGVHEAVELRDGDKNAYVGKGVTKAVANVNDVIAPELIKSGLEVTAQKEIDDFLIKLDGTPNKGKLGANAILGVSIAVADAGAAEKGVPLYQHLADLAGVKPPFILPTPAFNVINGGSHAGNKLAFQEFMLLPTGAFTFTEALKIGTETYHTLKKVISAKYGIDAVNVGDEGGFAPNVSGAEESLELLTEAIKKAGYEGKIKIALDVASSEFYKDGKYDLDFKNPNSDPTKWITGTELADLYLSYIKKYPIVSIEDPFDQDDWEAWTHFTKNSSIQIVGDDLTVTNPLRIKTAIEKKACNGLLLKVNQIGTISESIQAAQLAQSDGWGVMVSHRSGETENTVIADLVVALGVGQIKTGAPARSERVAKYNALLRIEEEIGNGVYAGEKGLSAGLNPPALLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5L7</accession>
    <name>A0A4Q9Q5L7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5L7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="8890" checksum="92BF2BE690F3D533" modified="2019-07-31" version="1">MHASHDRQTPSRSLCRHFSLPSLSPLVPVTATTAVTAAAPRASPRVSSGLSRVRSSRYLSISSSTYSRPTGLSIVWIGPRGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5P9</accession>
    <name>A0A4Q9Q5P9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_701650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5P9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5P9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2415" evidence="3">
        <location>
            <begin position="337"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="380"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="576"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="661" mass="72141" checksum="BEB26E116FB7DBF1" modified="2019-07-31" version="1">MPRASRIVRANLLCSRGARTQLRDVAICPHEKGIVSYPRGCSIVEHDLITPNASPRRLAELSFTPNTMSALILPDTNHTLLAAGGQEAELHLSYYDSSDSSTSTSTRSTRSCSRGFGRRLWESKYILENSSINNSVMLTSMSFSRSHQSAAEPRIVVSNNDRTVKFFDIAIRNGKAVDDYEPRLLDIGQLHLDVPVNHSSISPDGRTLLCVGDSPDVYLHRITGGSRITFSPIATLSLSSYIQHSHEATGGLSQVSSIPASFSSAFSADGSKFSVASQEGVVVVWDVRSTKPLKVFNTDKSRAGFSARIATGAASGWLYDAPWDWARGGARAPGWGVRSVKFSPPGVGREVMTFTEHTSLLHVIDARTFETEEIVRLPNFESPSLYQPPPSARPRSTSPTLRSSTTRSSTSSSDPLAPPRIVLFSGALEDTFRIPSSDSPFTWRTSRRARRLASRDDVSPEEDPESILVIPPLGDREVENDVRRLLGRHGMRRTAVLDPETDPREPLESATATASEGGRDREGDEMDVDELESDCVSSHAPSRAGSPAPASQMSLQSSGTRALELLRSRPTLLARRESSGPYAASRWGVSSSASSSSARRHRRGTGQGRDPRGEEGEEEQDIAGVCFDPTGTFVYVASAKGIAEWRVRGAEQRWWTEPQWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6F5</accession>
    <name>A0A4Q9Q6F5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919796</name>
        <name evidence="2" type="ORF">BD311DRAFT_746027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6F5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7623" checksum="478BE0A83E28DC60" modified="2019-07-31" version="1">MGAIISAIGAAINAVVSAIADIIMIIVSVIVTIIVTIFDIIFDILCCNCFGGRTRRTGTHRYRFGGGAGSATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7B1</accession>
    <name>A0A4Q9Q7B1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNF5-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_808633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7B1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7B1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006939">
        <property type="entry name" value="SNF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10019">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04855">
        <property type="entry name" value="SNF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="753"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="914"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1028"/>
            <end position="1043"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1058" mass="113644" checksum="734B97FD42612AA5" modified="2019-07-31" version="1">MPIAPAPVPAGAQAPGSPHVGMKRKASETPAPARTSTPASGNIPLAGAGTPGPQMARTYSATGIAGMGITGNVGPAQQQGLSQNSSASSLMGGAGGGMMPPPVLPRQGQAGDGMNIGMGLRSTMPGQAQNVNANLVPGVGAGSPSASLNLGGLDGGSAVGPVPPQTPRQNSLPPAAASPYQQIGSPGVNVPGMIGGTPTKPVVVKPGTSPAPTVSPAQQQQQQTVTVTKTQIVPQLPPLPATVQLEQKVTQVSVVPLADSEKAIPPLSAEEIARVQAWQQADRDYEVRRKKMLERVQEEMKKTVSAPRAWWEKDFSLGGVGEEQLKRRRGDKWTLTGLKAQKEREMKDKKRMGKREGLRLPRRISDEDAQRPEQLVPIRLEFDVEHHKMRDTFVWNLNDPIITPEVFAQSVVDDYQLTPSYHAIITKSIQEQLSDYKAHSATFGEDGAMIDEAEDIMHGKFSEAEAAWWEAWRKRVRSRALYKLPNPPDPRTRKRRKVVKDETVEQPTAAVPPSGDVPMTVDDFEEDENLMHEEMRILVKLDIIAGSYKLEDQFEWDLENVDPTPEQFAEIYCKDLGLGGEFKTAIAHSIREQVQIYQKSLFLVGHPSDGSAVQDDDLRMSLLPSLISGARSMEQVSAFTPQLNYLSESELEKNEKDREKELARRKRKTTRGRRGVALPDREPPKTYRTPAIGFPEISPAALALAAAAAAPTSRRAAAAAASLTIASMVASENRDDRDGALILPQTPITPIAPAAVATPAPPKEKKAKGLFKPPSYPSTVLRPRANVKAPTPSTAADSAHLPPPIENDLPAPSSSGIDRQGSKVMLTAKRAKELEREAKEKEYADGQHANMIDGVWHCSNCGCPESIAVGRRKGPLGDKSQCGTCGKYWHRHRRPRPVTYNSSLEYHMGLIRAEEQQKSSSKRKRPQSSVVEEAKSQVVDDEDMDTPAPAPPKSKAGKETSAAPDGVLAELPETAVSPVSTASSGSEPPLSHRIKVNGAHSKSAPPGPPEPVVKQESTNATGVVSPPAASPPRLAPSAPPTQNPPVGVGESVFTQFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8A6</accession>
    <name>A0A4Q9Q8A6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Orm1 type endoplasmic reticulum protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_917144</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8A6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8A6"/>
    <dbReference type="OMA" id="MTQQISW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007203">
        <property type="entry name" value="ORMDL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12665">
        <property type="entry name" value="ORMDL PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04061">
        <property type="entry name" value="ORMDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="238" mass="26666" checksum="7F096FBDA60B2960" modified="2019-07-31" version="1">MAVPATTSTLSPRKSASPSLTVRVGRERSSSIVKVEKVGEESQTDVLDQGVYDNLNAEWVNRKGAWLIHTVLILAGKVVIDTIPGMPQEISWTLVNLLYLGFSYLMFHYVTGIPFHSDLHGGVYDNLTLWEQIDEGAQYTPAKKWLFIVPITLFLASTHYTHYNPWLFAINLTALVFVLIPKLPAFHRYRVRFMVPDEPSRVGTPVTPNFPRSGTATPLGESAFSIPPIDIREVDSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A4Q9Q8F6_9APHY</name>
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            <fullName evidence="2">Acyl-CoA N-acyltransferase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_526511</name>
    </gene>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU63822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328:SF1">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
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    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="27920" checksum="869385DA54D76BC9" modified="2019-07-31" version="1">MSKPMQFHPLEFNPKTGEPFLRLPAPHENIIITPPRMSDAPAVVSNMADPAIYTFLEGPPFPYLPEHADQWLTKIKNGTDAAFEVLKRANEEKPDEPPILLEEPPVRTIREIREDGSELFLGDILFVRERYPDIDDKEVKKTLAQPNADRTLGDPDIVWCIGDYLASSHHGKGIMTAAIRTFIRDWAVPRMGARRIRVETFADNIGSRRVFEKLGFTYEKTVPVQKILNSGRTVDGMDILWWKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8R0</accession>
    <name>A0A4Q9Q8R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_964861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8R0"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="22371" checksum="64E6318130731551" modified="2019-07-31" version="1">MAVNNIVASLERDAPLSSDIIQINYPQATVDEFLRHSQTVVDSMLSASNRSLSPPLGLAAAAINIAVMPQTVDNEVVRARNRELDAARAHLDSQRDVLARERAECARLISKVAELRTRGKQLAAEARTLRAAQRLLAELSTRISTRSATIATIRSMRNVVAGIRGVVDGLRRVEMFVGPLALLNDAAFGVLDRRVAAIRRSRLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8Z2</accession>
    <name>A0A4Q9Q8Z2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_915243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8Z2"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9744" checksum="EDD09FE7F2FF3C9E" modified="2019-07-31" version="1">MPRGLGCFMLCVCGSRPTDHQSQFVVVASCNFRFTFIPRAYAQDHSLLFQTIKEKQAMIRRCTGTNTTKTPPLHSRSMDTPKRPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q931</accession>
    <name>A0A4Q9Q931_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sucraseferredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_840162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q931"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q931"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31902:SF14">
        <property type="entry name" value="ACTIN PATCHES DISTAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40327" checksum="EC6698346C4D9EA7" modified="2019-07-31" version="1">MDQTKVQLQGADIPVSDVPCRACPDPCDEGERRSLRHDEYPKFDVDRETDMLGSVKPYGRQIVISTGKTDWVREVTDAAGTLAAHFSDVASGGGHKDKQKDKGKDKSKSKKAEDKSGNGPSVAGVFNANPSKLKRVTIINGSHRTVSEDHSKETVLVFPDWKVLTEVEPTRAGAEALYEHSVSPSLPLFAPPPPEKAGSLKSWILPYSCVILLCSHKRRDNRCALAAPKLEHSLTQALEREAWEVHHQVEDPSVSGPALEDDPTLAGITSDTERHEEVLRRLQRVDAAHAEHKRVLILFCSHIGGHKYAGNVIINTPRGVSVWYGRVTPHEVDAIVRETIIGGKVLPPLLRGGMNLSQPGRKSLNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9F4</accession>
    <name>A0A4Q9Q9F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyl hydrolase catalytic core-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1014561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9F4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9F4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020977953" evidence="1">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="43"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="335" mass="36903" checksum="668392DF9AA18368" modified="2019-07-31" version="1" fragment="single">TRIAALLLFLTLFSRRAIAHHAADTHDRHTVYRRAVTNTSKAGLAWPNGNSIDINQYLSTGKVQWYYYTWGPSSIQSNIEFVPQLWGTKQLSQWDSSINGTIRSLNVTHALGFNEREISGQSNLSPSDASALWQAHIEPLKAQGILLGSPAPSSSPAGKQWLLDWMSACGGGCTIDFVAVHHHDINSTGFVEYLTDYHDTFQKPVWVTEWACQNYNNANEQCSQRDVVDFMNATQQFTDETDWLERYAWFGAMEDMQGVNSADALMSSGGKINQLGEQYIGMVAANVSPDYQPGIVHGGSGNSNPNGGRHTDVPDMALHTFFVLGVLVMVGATLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBT5</accession>
    <name>A0A4Q9QBT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_468493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBT5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043848398" evidence="7">
        <location>
            <begin position="31"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="382"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="419" mass="42434" checksum="882003F728F73188" modified="2019-07-31" version="1">MRCCSASAARVLTLFCIALFSSQSLLLVNAEPSTSALDLPFIGSEGSPTSTSATPTTTSITVVPTTSSSSSQVTTASPTSTTSSSTHSSSTSSSVHSKSSSTAPLPATSSTSSSSSSSSSVSSSSSSSSTSVSSSSSSASSTTSASSSSPSSTTSVTSASHTSTVTFVAAATTHALPTDTSLTSFTWSTSASPTATDAALSGTSASSKGFFDNKGAVAGTFSVVGVVVVGGIIAAIIYAKRRAARLQDEEDMTYFEKYEAPNNSSMASFNDGAHGSEPEMSYAGHGGAREMDVNAEPLATHAAVDAYPDRATHFGLPTMEEYAQPSDMGLSFGNAGVDYPPGMAPNAGVEYPPGMAYNPTQYGGYEGGYGYAATQHQQPYYDPSNLAPAPATHPYANPSNSPRMTAAPPVQQQYYGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBX0</accession>
    <name>A0A4Q9QBX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9227" checksum="3596B3F30B7DFE3E" modified="2019-07-31" version="1">MLYSSAYLDVCRAIDILISPHTWTDKEQWPLLQTDEVPVRRRHDSTATVLSSLSDAVALRVPSNHAFSAERQSDSGKGRKAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC37</accession>
    <name>A0A4Q9QC37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_972631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC37"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC37"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU65175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="9251" checksum="C68294C95E22CC03" modified="2019-07-31" version="1">MTSSTTASQTELKAAKVPIAWRDQCSALLIPLNVCRKDKLYLPWECENERHAYEKCQYEDYLRRMKELSKRKLAAAEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC48</accession>
    <name>A0A4Q9QC48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_283940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QC48"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16169">
        <property type="entry name" value="Tau138_eWH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046488">
        <property type="entry name" value="Sfc3/Tfc3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035625">
        <property type="entry name" value="Tfc3-like_eWH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20222">
        <property type="entry name" value="DUF6581"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="B-block binding subunit of TFIIIC" evidence="7">
        <location>
            <begin position="157"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor tau subunit sfc3/Tfc3 C-terminal" evidence="8">
        <location>
            <begin position="1595"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="516"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="886"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1565"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="574"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="661"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="685"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="708"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2189" mass="241217" checksum="A279EB0E3A7EB530" modified="2019-07-31" version="1">MDELVRHCLREISFDGDLGCDVSRLRDFVSEFYSHPSSSRVQGQNVDDAFCAFVWSVIVQQPGIRVGTTPEGSSTEVYIAPQVRAIKKAKAKGEDTTAAEDPPPATGLDIIEDATIRPLEDLRQQYGDKLRVAVDPETTFVALTGSHTRPSKLTPMIYTGLQIITRGREHGVSALDLGKKSGYDQKTCFYIIKQLVDLDLVVKLRQPGISTNIVVHKYFYERSPIWQQVVSEEKKAVSEAQAKEDGDSEEEDDGDETKPLEPVHFDPIDSRHLSSMPLLKSRLTKLLKACPHYMHTSNNLMLKIGFVNPTRTERRFFRTRIRELVDEGFIEKVHVPHADRRRFPDKKVPCIRLVTDDAVSQARGGTVPVEDDELEDIEMSQVEDYTGLKANASLHKQMIDRLAEAGTTGMTLNELSATLGDFDRRTVDLLLNRLEKDPPPAHLADLGIAQLSETHGRERRYKYYTVAHYLALAEKERFEDRRYRDVDMSAVGGFMPIEVEAFYEDEEELDRHVRLMSSTKSGSASLSKAKGKKRTNPILADGSVKKGRPRKSQVVGEDEEAVPTPSKKGKKRKREESLDGGAVREGDAAKGGEPPIKKRRGRPPKNHAASIATDGGLSEVAPIPKKRERPPKKAAKVDEPTGIMAGPSSEVQEGAVAAAKAPKKRGRPRKTREPTVDATPRDLVIAPAPANDDDIPPISAPVKDVPMLEDPSSSPLPSLSNSPTPAISSARAVISHTEDVAQPDPPSIAEDSQGAPEAVAISQVAPEVAASTGVRRSTRTPKARKQDDALSPLKKSIRRRPLSTTVPTAAEEPSAPLPTIDIVEADTQEEPSDKPSLDVITAGEGPRPTDPIPADSSTTDIPIDPALLGDNELSRMVQGHSLIAMSPAPEFPEAGPSTGTSVPHKRDQPDTVSEGPSTKRTKSGDSAKLRTKGNISQPRRENEILRLLAEADGIINTSSKEFYEAHAALVERLVVAGEPVSTRVGARIDKRTLEATLRELESKGKIKLLTTSAPTLTGSTRMARIAYLPRIPPDAVNTFLAELSQQLWSLSHNPSTSTAKTLEEPMDYGGIRKKTSGRVRPSIATEQEDGEVQEIKPIDLGALFQQDDQIIHDTLLTEKHTVAQLYGYLVGKAARARSLHLATVGLFGQDASSTQIVSKEHRIVHISYYFTDIPISTYCSLVAVLQPNEELATLLRSPAGQATPVGGVSDSLRNVLTPTQSKPRARILSLLDLLQVLGLVTPLIPSESDTPAFSCTGNVHHPAAFDVAPPDTYTPAIAPLYWRFNDSAPIRLWAIGEGVPAVWKMAPVSTSQQAALYWNDLQQVCTDPLHAQHLLGPAPASMGPASQEVATTCKSLRRTISWSAVYNLSFYQTEYLRRYIDPATGNTPLEDEDGARRDAQLDRLSWIVSASREVVASWFEKARKKQLRDIKKVKLASTKGKQKAATAEDAGVVVARRAAEAKEQRELAWEAMVQRVHPGELRHSAAQRVNRVRSKFIQSSAKPSDKWEARILEAIKEADLVADKLLSTAHPPLFAPMPVAKPALPAPVPTGLQEKDVDELIASQGARAAQGARTGKKTKKGKAKDTGETEVKVPRRHRFLWTRDYDELVRDASAIIKARCRGTTRLDWGAMEQIFPAVPRNSVRQRLVHLKEVPGTETYLSRLEDKWYDLWVQHRGTDVLPDPDPESATNFDLAMHVKFLRKHIDKNAIRVGFVEVQDSQKVDLPATIEDIKRHYDIVEKVPSAPTWDFMWSVVAEEAREKQFAHQAFTAEVGGMPPSPSYESEFLYVADTAVKMALGNPNETYDADVASRLLKGVGEEPVRATTTELLNRGVLAKTTRDPTKTKPGRTLKISDSNYNSLGGQLHRELFQDASALEELIVQQQQGDGLNAPHEQGQEWSLLATDGDTAFLLELTSENKVRFDVDTTHPQKMRSNIDWNSKKADDDDIETAIRVQYLDVSGPSRDALSEPSAEPSGIEVEAEMDMDDEHSLREHGTLADGEQAFCRRTSEGLIDCQACLEQARKSLFRGLNTDEQATVDKIIAALDEAGPTGLTKQELLAKLEFVRGDTLHTVVQRMTEGPVPLAHWTGYNAVVLVSSAAIRKWTVIVNDNATEEPEQPSMSEAPVLKSMIFPRRWLDIYGRKLHDVWESALRAVLGLVLLHPGISQVRCHAHLHLHLHLLPRLRAVPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCQ3</accession>
    <name>A0A4Q9QCQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_13024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCQ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020555070" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14904" checksum="60F659D5B76EE2C3" modified="2019-07-31" version="1">MNATPLSSLSTILVARLWACNRATVLWQTSQPHVEYSPIRQTACLLRRRARHDFLFTGVGDFHSANKCSSCPAVSLRQNTGLGWTMRPTEDLLPHTSYVADSSIGLRTLQRRRIRSSKCLSSRTSSKSDLDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCS1</accession>
    <name>A0A4Q9QCS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glia maturation factor beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1033883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the actin-binding proteins ADF family. GMF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCS1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCS1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071846">
        <property type="term" value="P:actin filament debranching"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034316">
        <property type="term" value="P:negative regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="ADF_GMF-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011171">
        <property type="entry name" value="GMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249:SF2">
        <property type="entry name" value="GLIA MATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11249">
        <property type="entry name" value="GLIAL FACTOR NATURATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001788">
        <property type="entry name" value="GMF-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="28"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18429" checksum="087762011DD4802F" modified="2019-07-31" version="1">MPPACSVLRAATAKAPTTVLAIQAIIMSHTVDIPQELKAALRKFRFARRNAGHAAMVVKINKQKLIMEEVEQFDDISIDDLAEELPENAPRYVLLSYELNHSDGRKSFPLVLINWAPRSSEMSLLTLHASAFVSFQTTADVSKVIEVREGAESFTKDLIDTKLLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCU8</accession>
    <name>A0A4Q9QCU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_805158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7497" checksum="37145FD947CE9175" modified="2019-07-31" version="1" fragment="single">PQSQTCVPALIPPGDDPSQVDIRTFYPTPPTSMTKVNASLRKKLAAELDMTPCGVQVRPRLSSPSRPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD25</accession>
    <name>A0A4Q9QD25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_306794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="35754" checksum="9A5C409370A18D09" modified="2019-07-31" version="1">MVSAWDIYAEQLFTLGYGHPLWVPEPCVESGEICIGDVGYLRAGGFRFIFSSMKEQDHPRNTRIGVPQGFQPFRPPGHQLVRRPNEIMQGQLHSANLRSTSLSGGVSVDAPATSGNAILRYHCSDSSGAILLLKRAGHYELLDCRLHIKTYMLEHISRWHEFANGDLGIGLQEKEILFVSGFIKTTEWAAAAFRSGGSNGELSISGGFLPLASVSGEFSVSMTRCDSPAVFYRSGPTRSETERLTSEDVAASDQCIFLHYYKMKSRIIWPTIRAAAGPHNLPPGSEDPEHDIIDNLGLEDIESTHDNPDKFDPVGCLLDYILEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDJ1</accession>
    <name>A0A4Q9QDJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_972643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9QDJ1"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="550" mass="62566" checksum="572053C73DD32381" modified="2019-07-31" version="1">MPLHLLDLNEDVLNHVVDKLYGGNALRFSLASKRTYEVAIHRVAAVVKCRRSDRLALIHRVLLNGPRPRAHHIEDLVIHAPIFLQGEAPYLPQVRDSNPDMLSLILDLISNAPKLRRLTLCEVDAPQMETVLLGLRNLNRIEFAGSTRWNLTVLSLHNYATALPSRVTAPPEELWPDTIAAFPQLHTLDIADFRTDDKSFRDIDGYTPPTFPALRKLFLFRCSSDVLDLACLSPYLHTLDADLAWGQFDLMLRVASRPGPRLSPLRSVLFSSILPALYATELMNTAYHLRITRTTLEDNLLSTHHLGVHLRERQAAALVEIVRTVSPVRAQLAAVIGDQSTEFWQRTSLAAPRMKVLELRLVFPSTLDSNRESPSWLDNIPAMLASLPLIGLRLHFGKMPELSKLQYSNDPLYEYDDAVYDAQKKLARELYSTRVQIMKSLPRRLTNAIHGLRVVAIADEEPDADYDGTPHVPRPLSESVGDHLDDSDEYEYQASWYAHFVRSLEWWRVMRNEEETVRLEALTWDQGTRVQRFFEDSDVTGLERIDGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K478</accession>
    <name>A0A4V2K478_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_964454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K478"/>
    <dbReference type="STRING" id="114155.A0A4V2K478"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF247">
        <property type="entry name" value="GH16156P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="141"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="3">
        <location>
            <begin position="343"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="895"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="920" mass="101398" checksum="D10C6093C807009D" modified="2019-07-31" version="1">MYSRHSPAQSNTSLSDDEDDFNNQSAFFRDTDSDSATITPAQWCSRRGSIPLKTPPSQASRLPPEILIHILKHLHSSRDLYHAVLVCRAWCECSVELLWYRPSFSKLHTLVKMMRVLSRDDSTFVYAQFIRRLNFLCIGADLTDTLFSRLAGCIRLERLTLINCNSLSDDGLTRVLPHCPSLVALDLTGVSEVTDKSIVALATSAKRLQGINLTGCRKLTDESVFALAANCPLLRRVKLGNVEQVTDQSVSALARSCPLLLEIDLNNCKNITDVAVRDLWTYSVQMREMRLSHCVELTDAAFPTPPRRDILPPGSNPFPNPFGSAPLPAIELPALRVSQPFDQLRMLDLTACSQITDDAIEGIVSVAPKIRNLVLAKCSQLTDTAVESICKLGKGLHYLHLGHAQAITDRSINSLVRSCTRLRYIDLANCLQLTDMSVFELSTLQKLRRIGLVRVNNLTDQAIQALGERHATLERIHLSYCDQISVMAIHYLLQKLPKLTHLSLTGIPAFRRAELQQFCRPPPSDFNTTQRAAFCVYSGKGVAELREFLAELFKSITNELVTSNDTDYDDDFEEDEVNHHSSRRDPDPEILDEDDDDDDAASEEMAPPPQRIGDMHNTPRLPERTPIPPEDISNRTFYPPVGRELMMTRETRRNPTPRAQPRAQPPNTPAWLNTVAARTRRGFGQQPIVEQSTSPTPSEAASNRSAGTSQSTGTAFFRTYADHPPTSARNGVMTPDLVYAEIGHGRGSGPGPSTILVQGHGRREPMVEPSLPSATSSPTRHAMGLPPQSSIGMAATEVFSAPLRTFRLHDHEARMEVVQDRGPILHDTSNSYHRPDGTVGFSVLREASPPSPTTRELQESVHSALGSPLLEGDARGRSVKRTLRSTFAAAETFFTGRGSGGSAPDGAGMAGGRDADTHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K708</accession>
    <name>A0A4V2K708_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_98516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K708"/>
    <dbReference type="STRING" id="114155.A0A4V2K708"/>
    <dbReference type="OMA" id="CTIKVKP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="30"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10451" checksum="F0EFBBAE57A1A316" modified="2019-07-31" version="1">MTEEQQDQPQEDVKPKINLVVDFEGQMKVKTLTPFKKLFEAAEKRFGKEPGTFKFTFSGQRLRPEETPAEHNMEDGDTIDAHLQQLGGASAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7H4</accession>
    <name>A0A4V2K7H4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">STE3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_1040669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7H4"/>
    <dbReference type="STRING" id="114155.A0A4V2K7H4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU56138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="475" mass="52671" checksum="8B65577C3CDB0839" modified="2019-07-31" version="1">MHADPTYPLLPVFAFLGFVIVLIPLPWHLQAWNAGTCVYMIWTSLACLVQFVNSILWKDTVLNLAPVWCDISTKFIIGAGVGIPASTLCINRRLYKITSVRTVSVTPDEKRRALIVDLCISIGLPVLVMILHYVVQGHRFNILQGVGCLPEIYNTPPAYPLVFMWPPLIGCVSFVYAFLTLLGFLKHRIQFSEVVSSNNAGMTISRYFRLMLLCLSEMVCTIPIGVYSIYINTAGVTLSPWISWANTHADFSRVLMIPAVIWRQNRSFLISVVMGQWVYIFAAFLFFALFGFADEAKRHYAMVFWWVMRWFGIHPKPKSEKMQFSKLSGISYGKPSPSSPDFHSLPPYSPPSAPYTPRKRPESLSPSLAGSFGDVDLERGLGHAKIPATQSEFSTEDAESVDGVIIISDECPASTPPTPVAPLRPVPPAAVPAYHRPFSPPPGAASDFLDLSSSIPRKASVGSISIIVHTETRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7M3</accession>
    <name>A0A4V2K7M3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_823128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7M3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22463" checksum="DF79F57563750198" modified="2019-07-31" version="1">MPALLKRLAGPRTCPIVVAQYKDEYRGVGHEADLHWALVVITDRATLSGPSFQAQGAERESEYEVQWYARHAPASLYDVCATVRTLCLGGVQVGAVRAADVGKLAEYLQSHPPAPTHAGWSSRDYVLELLELLRPFKMLREDLQRLDVRRGRAGAESARGGWRGTGSGTVEVGDLLPELREVGRATQESIFNEEFRPCVKYCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8S5</accession>
    <name>A0A4V2K8S5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_946831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8S5"/>
    <dbReference type="STRING" id="114155.A0A4V2K8S5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="243"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="459" mass="50812" checksum="5D56C25D4ED9E5DB" modified="2019-07-31" version="1">MSSSQATSKTPPLASAGSGEGKARGANRSTKVAGKLKVLPEHAEPVLEKDKVVQPSAPPRVKVDETGEGSGTLADSEDEEADEEDEADDAEVYNQIDLIPAGTARRDAIRLTKKKAKSLPRVTAYATASSYRFPELMKFFNARRGSYHTNPRIIVDVIYTPYVYEPPSAQPSAQSGTHTRVHFQTPSSHHQSRTGDLLGVPELAPGQSGTGAQGQLDAEASEHANDKGRKRSKFAETPTEAEIFIFEYGTVVIWGMTEAQEKRFLSSLKRFEVERLAPQDVEMEDLNFYYASYSRIYNDVITLRKGSSYMTKLSLSHALAQSVKISLFENLISATIEDTKDIPEIISETGKIDMNHKEIMRKIGELFLLRTNINSVGSVLDSPTYPDLQPLYDAARSYLEIPQRIDLLNARVEVLQDMLQLLKETVTSRHAERLEQIVIALIAVEIVLGIITILVDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K933</accession>
    <name>A0A4V2K933_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_919237</name>
        <name evidence="13" type="ORF">BD311DRAFT_39815</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Peripheral membrane protein</topology>
            <orientation evidence="1 11">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the small Tim family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143488">
        <property type="protein sequence ID" value="TBU24055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K933"/>
    <dbReference type="STRING" id="114155.A0A4V2K933"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="12">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU24055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU62358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10357" checksum="8BE750407B8CAC1E" modified="2019-07-31" version="1">MDFSAMNSAEQAHMTRVIERKQMQDFMRMYSNLVERCFNSCCNDFTSKALSSKEEQCVLNCTDKFLKHSERVGARFAEHNAEMMNGSGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWM8</accession>
    <name>A0A4V6MWM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_888002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145218">
        <property type="protein sequence ID" value="TBU53303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="136"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="282" mass="30636" checksum="6D960ED2D2A58A46" modified="2019-07-31" version="1">MMQLASGTEDHSALILFEVPSLDNTFGALLIGTICTSVHGKWPEEIPNHHADEYTGLGALCLGHNPRNAGHAFLIILVVAEIGECYISEISSFLTTCGWLVAFCITATVVTFVDVTFARFRQHSFWIIYTALGLRVVTDLVLTGSLILFLQRSRTGFTTTERMIDVLTLYAINTGLVTSLFSLAAAVAAAVLPDTLIYIAIYIVSSKMYSTSVLATLNSRKRISQLSVGRRTNPSSWLDMHSLDVRVPVPSRGHQLAETRDAIELQIKSTGSVIGSSSTIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M516</accession>
    <name>A0A4Q9M516_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_808652</name>
        <name evidence="3" type="ORF">BD311DRAFT_771143</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143562">
        <property type="protein sequence ID" value="TBU22014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M516"/>
    <dbReference type="STRING" id="114155.A0A4Q9M516"/>
    <dbReference type="OMA" id="YTTDKLV"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU22014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="11194" checksum="ACFDA0B6CC145A1D" modified="2019-07-31" version="1">MATAPTKQSILHLYHSMLKTSQSFSSYNFRTYFVRRTKSTFREIQNETDPAKLSAFYSEKAKELAVLKRSAIVNQLYGGWRLVVEEQKPERERGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MMT5</accession>
    <name>A0A4Q9MMT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_936424</name>
        <name evidence="6" type="ORF">BD311DRAFT_757589</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143418">
        <property type="protein sequence ID" value="TBU28785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MMT5"/>
    <dbReference type="STRING" id="114155.A0A4Q9MMT5"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU28785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="264" mass="29192" checksum="A09193D18E80919C" modified="2019-07-31" version="1">MDHFPTNWGRPRNDAADPYGTYPIHQRPATKDTFAEGVQRTQQPIVTGTSVLAIQYKDGIMMAADNLASYGSLARFKDIQRLHKVGTSTVIGASGDMSDFQAIQTLLDEVVTDEFTHGDGHDLGPAEVHEYLSRVMYSRRSKINPLWNSILVGGFRDGKRFLAYVDLLGTTYSAPSIATGYGAYIAIPLLRAAVDGRVDELTEENARALLHDCMRVLFYRDARSLDKYQIATVNASGVHISDQIHLDTSWSFAEGIRGYGAQTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MQT9</accession>
    <name>A0A4Q9MQT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyl phosphate synthase arginine-specific small chain</fullName>
            <ecNumber evidence="3">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Arginine-specific carbamoyl phosphate synthetase, glutamine chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_806791</name>
        <name evidence="14" type="ORF">BD311DRAFT_660895</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CarA family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="3"/>
    <dbReference type="EMBL" id="ML143412">
        <property type="protein sequence ID" value="TBU29567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MQT9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MQT9"/>
    <dbReference type="OMA" id="CFSVQYH"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000016">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific small chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050472">
        <property type="entry name" value="Anth_synth/Amidotransfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418:SF7">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43418">
        <property type="entry name" value="MULTIFUNCTIONAL TRYPTOPHAN BIOSYNTHESIS PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carbamoyl-phosphate synthase small subunit N-terminal" evidence="13">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU29567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU64540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="376" mass="40927" checksum="CB4CB866FFB5A32D" modified="2019-07-31" version="1">MTDPSYRGQILVFTTPLIGNYGVPYNKTPINSNDVGVILESENIQCSAVVVADVAEKFSHYTAVESIASWCQRNNVPGITGVDTRAITTLLRDQGTTLGRLAVGADASLAPPKPEEYWDPTTENLVAQVSTKAPYELNPNGDVRIAVLDFGAKANILRSLVRRGAAVTVLPWNYNFNNIRDQFDGLFLSNGPGDPNHCLEAAMHLRKTLQEWDKPVFGICMGHQVIGMAAGLEAYRMTFGNRGHNQPVLALASSGSIKAGRVYVTSQNHQYALKLQDPFPAGWEPFFINCNDSSVEGIKSSADSGKKVWGVQFHPESAGGPLDTIEMFTDFLAECRAHKLQLSLPTSQPMDARKVAPRLGVETAKIETPRRVAVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MTW9</accession>
    <name>A0A4Q9MTW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_921504</name>
        <name evidence="12" type="ORF">BD311DRAFT_688883</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MTW9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MTW9"/>
    <dbReference type="OMA" id="VKMKLFQ"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="11">
        <location>
            <begin position="54"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00058010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU61111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="40113" checksum="12DCDC225A3EA42E" modified="2019-07-31" version="1">MASGSGIALKTFNLANDIKELSAQDEIFRYDPVENRRINNEKPWVRDPRYFQVCKISAVALIKMAIHARSGVPYEIMGIMQGKVVGHSLVVIDSFALPVQGTETRVNAQNEANEYMVQYVQGSERVQRLENAIGWYHSHPGYGCWLSGIDVNTQMQNQKFQDPFVAVVIDPNRTISAGKVDIGAFRTYPENYTPADAANSEYQSIPLNKIEDFGVHANQYYPLEVQIFKSSLDAELLGLLWNKYWVNTLSQSALISNRAYAANQLSDLHQKLTKAQTAVPSTRPPAPVLIDEKAVIKQKPQDKREESALSKAVKDSDKIASEAQHGLIAQVLKDIIFSSRLGGGAGSSAADVRDIVDTAMSIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MYA6</accession>
    <name>A0A4Q9MYA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_902952</name>
        <name evidence="2" type="ORF">BD311DRAFT_737276</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MYA6"/>
    <dbReference type="STRING" id="114155.A0A4Q9MYA6"/>
    <dbReference type="OrthoDB" id="3357948at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU31561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="714" mass="78002" checksum="81E1A5D889B00162" modified="2019-07-31" version="1">MSSPSNSSVWITDVSSAPFLDSMLKASKYSEVDNYSASEYDDVSTLVGDRSDVLVDPSDQAESLPHPASFDCLGDSSSTTPHDDGDGDLGAFVEFELQDVSPKGVSDASSLRSPEEYDNSISSGRQSSATLRDDEVCECYTRRIKGWSFRKEMTDGSNVNTVPPSIHELWRHQYLGRFKVEKRWREGPSKALTQRINVRQIADPLPRGNTKDGPHSVIHRHSRVVAFSIFRKYGLFERAHKPGGTSFHVHSSQAILLATTDVQAKGTGRSSQPGVSDSINQAASPGGFILNGARRAAISRIMEAESPIRRPYTTSPISMSTSPTVASPPDTSTDSATFTIAASGGTICPRLTLDASITPYDGLPPPVTQNGLGEEGMDLEDSKTRRSRTSHAEAFATLGLESIASIRWSSRNYVEHEHSGGGGILERIARRIRGSNFGARGKPVGPLPYPLFRSTLPPWVTLAPRSKQEERERFLRNLNEIVKGVDLFRHIPADAFRMLLPLWPCDTDEFSTLARVDGSKYIRPVEERQYLIVYYVPFDDCGDKGTQGDTNSKLPRADSLTIPTFIASETKRIPRSAFRVCARLVSREDFLGTDVRLPSEGLAITGPMAEAMAALPPASIREQHPGDVVIGVCSGKEKEVEFLPEGLVSIGLAMAIEENRPPRPPLPLHEEGMMDEVSPTYTLTPIGRAAVEMAWLGCLAITFLDVPSPQAVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N094</accession>
    <name>A0A4Q9N094_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ARF/SAR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_915573</name>
        <name evidence="6" type="ORF">BD311DRAFT_687660</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N094"/>
    <dbReference type="STRING" id="114155.A0A4Q9N094"/>
    <dbReference type="OMA" id="VRWSKDQ"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04151">
        <property type="entry name" value="Arl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000624">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU32046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="187" mass="20708" checksum="B27F5D81224E0A09" modified="2019-07-31" version="1">MGLSFSSLFTSLSSLVRWSKDQDVRILMLGLDAAGKTTILYRLQIGEVVPTIPTIGFNVETVQYKNIKFQVWDLGGQSSIRPYWRCYFPNTSAIIYVIDASDVDRLDTSRSELLTMLSEEELAGVPLLVFCNKQDVAGALPPETISEKLGLAGGEKERQWSVRGSCATKGEGLEEGLDWLVNAIQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N7G9</accession>
    <name>A0A4Q9N7G9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_954457</name>
        <name evidence="3" type="ORF">BD311DRAFT_773292</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N7G9"/>
    <dbReference type="OMA" id="KWFYAGT"/>
    <dbReference type="OrthoDB" id="2804448at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU35141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="40221" checksum="B2B27DECDB3420CE" modified="2019-07-31" version="1">MVSADELCALQEENLQIRSQIADAKANLHHIDGNPQSTANHNEQLSQLSEEAAQRDAEYARSRERLSAKIEAMRGKCKAEKEMGSKLRESISEAETQVSDIERMNEEQSGRLQDLRDDLTRAQGSAVPFDFCAFLGDVGGETGAPPTVSVPAPQSALVLPEAVTSLCAPGGFLAKKRQEVILSSTRAGSRCLVLAPTHLYNPKSNNSEGGWQVTERVSQPPENTELFYRENTTHWSYLGTFQFVAQEERSLQDFGRMAKEAMQVIRDNTTLFPEMIPPILKGLIRNMYDCGLLKVTYTAWRRVGFNEGLADALRATFQPPRLIGESTVIPVPKPGSWLNHRVPTKRDREEDLGVGSHKKSKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N8U9</accession>
    <name>A0A4Q9N8U9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_313955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145284">
        <property type="protein sequence ID" value="TBU51805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N8U9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12434" checksum="9524D9F970271D0F" modified="2019-07-31" version="1">MAFAIVCLGHKYQVDQLVAQGIAHPIECYTGDLDEPRDAIAAAFDIAHLTNTRSVLPIAYLHTCSAGARRSGCCSERLGSPGPERVVDARSKLMGYASRRSSRSSRGTGIWVALW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEX3</accession>
    <name>A0A4Q9NEX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_875740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEX3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="37042" checksum="BA7C7FA5A0A43561" modified="2019-07-31" version="1">MYADHADYVFQVSYYLGTLFNALLYGVELVIYCASVHIIIRCGAKPMRSRGARFLLAFSTGLLLLTTVWAAIEASLGQRMWIANPNYPGGSAEYLAKNAPMGYKIAGSAAAVVLNMMTDGLLLYRCYVVWADVRVIIFPLFLYLSTVPLGILALFVNAVESNARLWLGGMQPYTLAYTSVAISSNLLVSALICVRILFLARHTRAALGDEAAHMYTNAVALVVESALAYAVCGVVYVVVLAVQSSMSVMFASCYVMFTCLASQMIVLRVLMGRAWTQEAVARSTTRIQFTTVIVVACPSSDATQNSHESGIGHSRVPIELWTDAELASCDDHGDLIERKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLP3</accession>
    <name>A0A4Q9NLP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_939045</name>
        <name evidence="6" type="ORF">BD311DRAFT_689663</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143401">
        <property type="protein sequence ID" value="TBU31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLP3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NLP3"/>
    <dbReference type="OMA" id="SQIHGTQ"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03359">
        <property type="entry name" value="LbH_Dynactin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20825" checksum="4518EBD3E731D688" modified="2019-07-31" version="1">MDLPIYYTRAEYIETDTGNKVSRRATISGPQNIILGGKTIIASGAIIRGDLRRTGPGHAVVISLGRYCLIGEGCVMRPPYKTYRGNFNYYPMKIGDHVHIGANSIVEAATIGNHVEIGKNCIIGKFTIIKDCAKIADNTVIPPNTVVPALALFAGSPGRFVEDLPESTPEMVEAQTKQYYTRFQPLPQER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQS1</accession>
    <name>A0A4Q9NQS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_851066</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQS1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11957" checksum="A1325CCFA6387B36" modified="2019-07-31" version="1">MSGYIHLARDSVEDTTKDQVSKEALLSADSEHDQWSDEQTSTRARSNLRGVVYIALVLLLVNVLVWAIAGSKLRTIYHTIQDNLDVVDTRLLPRPDVGNGVKLTAQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUG0</accession>
    <name>A0A4Q9NUG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase/formamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_875635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUG0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NUG0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.20">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="327" mass="34901" checksum="5D5034875C2919B6" modified="2019-07-31" version="1">MSIHFVKRSQCHLAWDNSISPVIHISSGETVTFDCLDASNGQITASSDITSLASLASLVFSQLDQVNGPVHISGAQPGDTLRVDVLGIETADWGWTALIPGFGLLADEFPEPALKVWKLVRKVDGKDVCGNGEYGYGWFDEKKGIKIPLKPFAGEMGVAPGKAGAHSTIPPYATGGNIDTRHLTAGSTLYLPIEAEGALFSIGDGHAAQGDGEVCGTAIETPMKVSVRLTVLKDKPYVKTPHFTAHNPHAGTEQFYCTTGVDADIRDATRAAVRNMIAFLKAEHGLSAVEAYMLCSVAGDLRMHEVVDMPNYVIGMMLPKSIFTQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVN5</accession>
    <name>A0A4Q9NVN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_869502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9NVN5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056396">
        <property type="entry name" value="HEAT_SCC3-SA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020839">
        <property type="entry name" value="SCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013721">
        <property type="entry name" value="STAG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24571">
        <property type="entry name" value="HEAT_SCC3-SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21581">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08514">
        <property type="entry name" value="STAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51425">
        <property type="entry name" value="SCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1238"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1324"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1374"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1449" mass="160107" checksum="8F42FE7A6528E576" modified="2019-07-31" version="1">MPDTPEPRRSQRERKQATQFVSVNSSLLSKRKRSDATDDDENDKPDALSELSDPAPTEDEADDEDGAPEPPAKTPAKRKTKAAQGPKKPRAPKGTTAKKTTVKVPGPPKPKKTTGRRGKQPAGADVEFDAEQVAKTSKISGDNPLFNAIMNPAAALQSTAEDFLESLSNTPGKSLAELINCVLRSCGCNDSVDEDRAVDYDGVVDALDDFTEILKKDDTPIYPLTSKLPIFKKFRKSLSEFLERLIISSAELGSLYTSDLMPTLQTWVIAMSSSQLRSFRHTATVIALEVETALCDVAASVEKEAEVVSRQREGERKRKAAGNKGKAGNARDADLEKKAAEVRERRSKLAEFLKEFVDGVFVHRYRDLDPNIRAECVRAMGLWFKKYPAHFLDGAYLRYVGWVLSDAHTQVRLEAVRALALAYDQTAYIGAAALQHFTERFKPRLVEMAVGDVELGVRVAVVQVLQTIDGHGLLEDEQRQQLCLLVFDEEARVRRAVSGFVKGVWEETVEERLVGRKPSDADKSRAGVKALGMLLVNWGRALDKSAGDGDGDDESDLGEGTSKRVRAKEVASLVGHNPKGRTALVVEALWDEVEPVRDWETLLGVLLLDHSAAGEGRPTSRSKGKQTVSDEAVDEAYRLEEVEEAVLLEMLVATLRKTLADAAAASAKKGDEDTTLSDVTRALIKALPRLFVKHQTDESRISDVLLIPQLMNLDMYLEMRMMTAYSSLWEDVTKQFLSHSSPVVLANAVATIRRLMEATSLSKTNSAKILELEDELSTSLRDAIAGRDEIEVASFTEDEVLALGAICARLAALSGIRDMTAWMEEDEGGKQSSAWDIVSALAERGRLGYKEEEMMVDRALQLLTLHIMWKARSLPAAAELSPDEIQFRDKLKEERESLLEKLVEFAVGTQSNTVEGVRRAAFQGLLTLHILFCATETTASDGSRLPTAALPLSLDDEVQQRCADFVQSEIERYAEEISEEQPEEHGSSEEDDEEEEEPEPEEQPKGKKGRSKGKGGAKPTTPAPRATTRAQLEKEYVFMGVVTTFLRAIRAGVIHFRYAATILAHYGRLGPTFDLCTKVIVEILREEGMYKDNGEEVVAIICRALQESFILYLESMVHTADHAIALGKALSACLLIRGAQLAVVRRLDPKYVVDIHTTSLNWVGKRLAGYENIKNKKARNKCILFFRVLQPLLSSIDNQDSLKIKAHLDNIIAQSKLEISPTSKPWEPYRAYEKKLSSALMKEKGPGRRGRKRKDAKSAEFVTTDEEGGEASEVEGMMVNGDAEKPRRRNPSRRAAQNGGVSEGEPGITEDENDGAAPITTPKARPKPRPVRKRGSPAKRAREESPARTPSPAPARQSKSPSALSSARESAPPEAEELEEPEDLEEESQDPETPKASRKRARTDDEEQDEEMRDATTNGINHDDAAEKAEASQETQASELKIRRKRVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVW8</accession>
    <name>A0A4Q9NVW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_930584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVW8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NVW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="270" mass="30140" checksum="B121F7D9F49736CD" modified="2019-07-31" version="1">MAAPPMYTANPTQVIALSLPINQAPSDSVPYELQKYYSKDIWAARQRAVLMKGSRYLKPRFEIIFAVFMFLSMLAVPIVIYYVALHTLPAHLTQVGETFNGERIFNDDRVWEARAASVGALVGLILLGWVPLFIWKARGKRQVNQMLRKFSVEDAAVAGPSAQVPQWSMKMPGIGSKAIHLMISYPRPPMSSPFQLGLPPYLVNPPMDPAAAGYYMQASHTPGQPHHAPGNAMSGIPLYNENEEKIPDYSGPTNDTYLPHEKERFEDIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P330</accession>
    <name>A0A4Q9P330_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_911130</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P330"/>
    <dbReference type="STRING" id="114155.A0A4Q9P330"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="294" mass="33661" checksum="0F92A09B439C3AFE" modified="2019-07-31" version="1">MASLLKESRKAKGKRNADDMEIDQDHGPVMKKPRNKQRVLMLSSRGINHRMRHLMNDLEALLPHVKKDSKLDSKNHLHLLPELADLNNCNNTLYFEARRHEDLYMWAAKTPNGPSIKLHVQNIHTMDELKMTGNCLKGSRGILSFDKAFDESEWGKLTKEVFTHIFGVPPQARKAKPFIDHVLTFSILDSKIWFRNFQIIEKDPLQPNGPPQMSLTEIGPRFVLTPIRIFEGAFSGATVYSNPEFVTPAAVRSALKREKGDKYGNRKHAQAERGSRKDLRRLEEDELAVSKVFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7I1</accession>
    <name>A0A4Q9P7I1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2OG-Fe dioxygenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_412623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7I1"/>
    <dbReference type="OMA" id="CDWSVDE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018724">
        <property type="entry name" value="2OG-Fe_dioxygenase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10014">
        <property type="entry name" value="2OG-Fe_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="325" mass="36353" checksum="27CF12C678C326B7" modified="2019-07-31" version="1">MMHRLFAASRPAFRAATLTRVPRRSLAAVTSDLQTPSSRLTPPPITVRRNLKFTNPLLSYRQNYPPLDNADYIRFNPTADPSFANPNQVAQFLSSVQAHFDTLPSDPHAPATTARFRQYSRAFVLPFEDKPRVYWAPGHAQEGRDITYYNQGVFNPEHESERRAMPSIPDSMRSELLEKLILTDVALCDWSVDELRHPIIVGVHFIKTAPTQEHPVSKTTPNSLHQDGHKFSFVHLVQRRNAIGGENVIAGKGGRYAGLQPSEVPSEDVLARFYLESPLDSWAAYDAKCSHYAGPVMQEVVGPEPSERSVIICDIEPMVAAVCPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7Y5</accession>
    <name>A0A4Q9P7Y5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="3 11">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_912401</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="3 11"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7Y5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7Y5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000012">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="12">
        <location>
            <begin position="7"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU65943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="325" mass="36102" checksum="65FA67E90CD96579" modified="2019-07-31" version="1">MGPALDIPLHVKYIQSLGENKDDLVYHLTAHLRMNAVYWGLTALLIMKHKDALDRDEMIDFVMSCWDDEAGGFGAHPDHDAHIHSTLSAIQILVMQNALDRVDVPRVVKFILSLQQDSGVFAGDQWGEIDTRFLYIAVNALSLLGHLHELDVEKTVGYIRRCRNFDGGFGAREGAESHASQVFVCVAALAILDRLEEVDQDMLGWWLAERQLPNGGLNGRPEKLEDVCYSFWVLSAMSILNKVPWINAEKLTAFILSAQDPEQGGIADRPGDQPDVFHTIFGVAGLSILGYPGLDDLDPVYCMPASVIESLGLRKGWTALPRRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P854</accession>
    <name>A0A4Q9P854_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_996884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P854"/>
    <dbReference type="STRING" id="114155.A0A4Q9P854"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="233" mass="24850" checksum="A1606E9745D1DA1A" modified="2019-07-31" version="1">MSSVDDLVASLNANHIGQEAMELAALQAQLQQALLSQQMAHNASRSGPLNSPVMRTPSASISLDPSEAACVRHNSVSSTKMRCPIDETPESDDMDEDERMVEDLLLASPASPSTSSAPFSRTPQSSVSGVSHSPAHRPRKTSLSVHMIPLDHSHHELPSPNTSLFTTTDPFYLASLQNAHSHAPSSSVFAQAGRPSAHSPFLKHHMSYSSFGHGYQSVAPDHMFAATAAAFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAT4</accession>
    <name>A0A4Q9PAT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_250054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAT4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAT4"/>
    <dbReference type="OMA" id="LAHIVMQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="393"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="264"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="473" mass="51124" checksum="D65F33D70C17BEC8" modified="2019-07-31" version="1">MANLPSDEPQIILNSDTTRPMSIDLSLELERQLEAESLPNSPNPPRPQSLDTNVLANIVTQLRLSLAEITKERDTLAEKVTEAQTREEGMRETLEHVTDKCIRMENELEVVADQLRESKETIVMLRGKVEESRRALMRLQTEKRMSVASNLTLDLSRPPPTQTSLSGPPSSKRASFAPLTGSPAGRGGYNHRRISSVSDSAFLLTGPPNGEPSTWPPPSPMSQYIPEVPESNPTDRPGNNRRMSLLFGRGAATPPEPPSTDTDVVELRTQLRTMQRQLDDTKRDLIESQEAREASEQCVRALRTFISENNVGVASALRTGSPAAAPTTPSHSKQGSTASRWGFRLWTTSDADSPKSATPALTPISMQAPEPGSAVSSHSQAIPRKFGGLFNAKTSIPSNASPRPSYDPLHQEPMFNGSDTSSMADSTGPVSPVSEVPRTSVGKLDGKPITSGGDEVEITSLDHGQDIPVASTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAY8</accession>
    <name>A0A4Q9PAY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Family 92 glycosyl hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1043458</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145297">
        <property type="protein sequence ID" value="TBU51638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAY8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAY8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF43">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11017" checksum="244C627EA99F4E62" modified="2019-07-31" version="1">MSAWYIFSALGFYPVTPVDATYVIGTPFFDRVAIDLPNASRPLVITSSGAPSKPYIKGLTVNGKPLETPFLTHEDIAFGGEIVFEMSSSPQTWGSATLVGTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBJ2</accession>
    <name>A0A4Q9PBJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidase M24, structural domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_921019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBJ2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBJ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF4">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="525" mass="58005" checksum="03EDFFA9C2CE8515" modified="2019-07-31" version="1">MFARSLPLPTCPRAAARAASSSRAALTVSRRAHTTARCNASAVTVNGHSQLKPTIYGQPLAPSHAHLIRSEETTPGIPQKDYDIRRRKLMENLPEGSLVVCVAGQVKYMSGLIFYKFRQSSDFWYLTGFDEPDAAVILEKRPSSPRGYYMRMFSVGTDPAKEKWDGARTCQEDVVQYFGADEAEPISVFPSVLRSLVANASHVYFDLPSQSKRTRAVSPKSLLKYLSSSGAMSRTEYDSLFDSLSSNTRKALAPEVGRLRAIKSKHEQEVMRQAADISARAHNKTMRFTEPGMTEHTVAAHFEYLCAREGAQRPAYVPVVASGPNGLIIHYTSNNQLIADGEMVLIDAGCEYNGYASDITRTFPANGSFTSEQATLYNVVLTVQKRLIDLCTESSAMSIVQIHRESCNMLRKELERIGFHFPLGAGTLDALYPHLVGHPVGIDLHESNHMDRHEPIKEGMVITIEPGVYVPPLPEFPKAFHNVGIRIEDEVLVRKNHPEVLSANAPKEIADIEGSCQGLLGLTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD63</accession>
    <name>A0A4Q9PD63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_1042836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="ML145238">
        <property type="protein sequence ID" value="TBU52739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD63"/>
    <dbReference type="STRING" id="114155.A0A4Q9PD63"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000002">
        <property type="entry name" value="Putative Ubiquitin-protein ligase E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="656"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="960"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU52739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="992" mass="112213" checksum="48DBF025B005D27F" modified="2019-07-31" version="1">MDVPLFGDQPNKRRRHINLGGIHSATTHNDILQDAKLRRSQREEQKRRQDAALHIQRIWRSHLARAAVRQSLRATFLQDLSSLTALRCLVLLGQDEDALGRWSTVILASKRDVLLQSDQSWLVLLQRVSTMLLRSLSTDPRSQYAQTHLQVLSLLLSGNPKRADVSRYLLSHGFYSSLRQVVLQLPAPFKPSPLIAPLADLLAAPLSYPELLPLSLRELLSNILTIPLFPNRILPALGPFSARLPLASIHVVPLDIISAPELQSLESKIHLLANLVAFMPPRYAALSPPAFATYLQLCALLMNALPTHALEPPEDKRDAARNWADGESEDEEETTVEVVSSFEPKQRLPPLDDRTRKRLLIIPASDHITSLLRASQNENLLQPVVAYSLALSTVWPSRRDRVLSAIVMYNRGSLVKEIFRTFVRSSPLGRDDAQSEISNPKNAPHWPPLLLLADLYTQALLTMGDDEFFSTGVTPSVARNPLSLDELTGFSRQLLNIAFTLYWREDPNSAQEAVPGLGQVRWENVREKATKCLQALHARDSRRPFTPPGHWLITAHVDMNTFIKAAVFEERQLSVPENGRVAPLNKRQLAYLSPRLGVLNNIPFAIPFDVRVEIFRQFVQNDIVSRGYMPWRGRMGAAKIVIRRDHIAQDGFDRLADADLRAPIAITFIDQFGNEEAGIDGGGVFKEFLTSLTREVFDTDRGLWLATKKNELYPAPHSYATEPHSLAWYRFIGRILGKALYEGILVDIAFAGFFLAKWLDKQSWLDDLASLDPELYQGLMQLKHYTGDPEELSLNFTVAQEEFGVTKSIDLIPNGSNIPVTRENRLQYMYLVAHYKLTKQIKKQSTAFFEGLSEIIDPKWLRMFNQQELQILLGGVDSPIDVEDLRANTQYGGLYDDHHLTIQLFWEVVNELSHEDRRKLLRFATSCSRPPLLGFKELNPHFAIRDATDDQTRLPTASTCVNLLKLPRYTDRRVLKEKLVQAINSNAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDH9</accession>
    <name>A0A4Q9PDH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_864022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDH9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF3">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G13270)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="367" mass="39036" checksum="21F9C3EC6307DFF8" modified="2019-07-31" version="1">MAAIIQIPKTTKALVLRRAAASGKSVLHDAVVEERPLPQLKSGQILVRVHAAAFNHRDLWIRKNLYPGIGFGRVLGADAAGVVVASADKNDFLLQKRVFLLPMRGWEKDPDAPESDFIIVGASKAIDFGTFAQYIVVDRDQVIPTPDHLDDVHAAAWPLGGVTAWRATIVNGAVKKGDNVLITGIGGGVAILALQLAIAAGANVYVTSGSEEKIRKAIELGAKGGVSYKNNDWPTQLGKLLKENGKGLLSAVIDAGGGDILGKTSPILKQGGRVVVFGMHANPKVTITMREVMKNQKILGSTMGSHKDLIDATNFLAEHRIVPVVSHVLDGLESADEGFKLLQEGSHVGKIVIRIPPVSPQAFPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE94</accession>
    <name>A0A4Q9PE94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin MVP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_860698</name>
        <name evidence="12" type="ORF">BD311DRAFT_866222</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143434">
        <property type="protein sequence ID" value="TBU27284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145221">
        <property type="protein sequence ID" value="TBU53224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE94"/>
    <dbReference type="STRING" id="114155.A0A4Q9PE94"/>
    <dbReference type="OrthoDB" id="10064318at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028662">
        <property type="entry name" value="SNX8/Mvp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045734">
        <property type="entry name" value="Snx8_BAR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47554:SF1">
        <property type="entry name" value="SORTING NEXIN MVP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19566">
        <property type="entry name" value="Snx8_BAR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="11">
        <location>
            <begin position="233"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="193"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU27284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU53224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="683" mass="75130" checksum="7EBC4C300734070B" modified="2019-07-31" version="1">MFNAPRPVQAYGSSSQFGASFVTENPLISSVYDDGLDPWSTSPSPAPPALPSFGSTSSGFSSVIGDATLPLIYNRAFSAVDPSNTGETSVNALSRVLGTSSLPASTVDKIVSLVSSRPRVSRLEFFVALALAALAQSGKDVSVERVAALAQENALPEPALDLNSLPPTNSTFQDIMQMPPPIPARGYSTEDPWASRFTSPSAPPKPPPAFSNHTNGAPSSISGTGLPREWWKKQETVFVNVLGQQGFILNRYLVYEVSSDRGAPVPRRYSEFVFLWDVLVKRYPFRLLPALPPKRIGPDEGFLEQRRRGLARFINFVVNHPVIKDDAVLQSFLTEPSLEEWRKHTAISYEEESASKRVDRLEEMAIPSDLEDKLAVVRGKIGFLIEHWQRICLLTERIVRRREAAAVRLTPVMRPSFLPTHLPFPLPSFGGLSSSPSSASSALASSSSGHGYGSGSGSDRDADSSSSIFSGLTSGARGTTLLDGQADLARLTNTMKSLVESNERCWRGEDCELCAGVRQGLVHVSTHTQRHADALEHRSRTMLYSTLEALKAQRDLYVAMRDLFIRHDRLSLDQVDRLRKRVDTNSHKLEGIRQAQKEGWQQEADKIAGLIEKDQAAIAAALARRVFIRACMWHELRVVLHNRENTLLTQAVRSFAREEHDFSEGAVSTWASLLAAVETMPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEF2</accession>
    <name>A0A4Q9PEF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_889309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145248">
        <property type="protein sequence ID" value="TBU52495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEF2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="559" mass="61789" checksum="3C03CC2C7498657E" modified="2019-07-31" version="1">MQFVSLPPELLATILLDLGFRDLLRCRQVCSIFKSVIDGDVRAHYKVELAAAGMEDGPPSALTPAERLSILRRRQDAWTKLAWTAKEEVPMRRGGVWELYGNVLAQAEGERTLHFKQLPSAIRGIKGKEWTIQDVGCKIRDFGMDSAQDLLIVLEHCSEPDGSEVTCRVHLRSLSTGAPHPAASKTGILTPCLPEGRCTYTIQTSEDNLGLLISGLDELIYKLVIFNWKTGALRLCTAGPDLPSFAFLSTRHILIAILPELELTEDNNIRGPNDPYLIVVDVDANPVPYPPAPCESSPAPTCSTDLKYVCAFRYPRLGDTFIVTDISIRSDPAPNWRPSPSLGVPFSVSREDRLLVITLQLYEGPTRFGIFSLVLTSTFLSRVARVEREGAETGGGDVGWTEWGPQGSRLLLAPETHTRVWVCYVYGTTFGLLRWRGSRKVVLTLDFNQLAIRRARLKGGGCFGLGDSAEAAADGAWDAGGVKMTEMTAFRPGRVFKEEVATGLGYWLRMLPSLPFGDEESSDGTLDEERQFEAVMLAEDAFVVVSDDEDVRKYRILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGT2</accession>
    <name>A0A4Q9PGT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_225417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145246">
        <property type="protein sequence ID" value="TBU52542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGT2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35019" checksum="57DF9D2957196D09" modified="2019-07-31" version="1">MLLKPKKDETFFSSPSLTWQESPSSAGILVAMVHHTLQRLLISIDSDAEMPIHNLRRLITKVSVRAPGITSMVLQSPDETRSFPVDGLLKHTQLRELTLGGGIAIPSEEIRTLLSLPHLHSLQVNLAASDPCPDETFTHAVTGSYNSTTLRKFACAVSCDTATTLLSLLDASYLESLILHVDETRFHQRRSAHSLLLRTVAGASFASSVLSLEYSSANIYSELGPKAHQSMNLDPDDIPVDLSLDQPLSNILTPFFPATPSLDLPKLERFSFDMFWPTAVQDEDVEQLSVAIGSTARILEHTPLPPSLRAIRWHILPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH10</accession>
    <name>A0A4Q9PH10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_939669</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145240">
        <property type="protein sequence ID" value="TBU52702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH10"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="53" mass="6079" checksum="F0660174E5B783BA" modified="2019-07-31" version="1">MAWWRLAKPANAVRRHPELSADHLTLPCSGHTPPLTYRQAGSSRSRIELLRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHH8</accession>
    <name>A0A4Q9PHH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_183164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145228">
        <property type="protein sequence ID" value="TBU53011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHH8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHH8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046621">
        <property type="term" value="P:negative regulation of organ growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16461">
        <property type="entry name" value="RING-H2_EL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033276">
        <property type="entry name" value="BB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46400:SF5">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46400">
        <property type="entry name" value="RING/U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="1014"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="292"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="403"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="783"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="464"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="511"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="669"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="863"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1065"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123980" checksum="F9A9CB128A5F3269" modified="2019-07-31" version="1">MAEPCFSSDIPSMSSTHKRSFDDMDPELGARLVETSRRDSSVGSSSSPGGSRERSKRPRNDSESEVDELLVSSNTSVSSSGSSSSLDSYHSARSSFTDISPQLLPADDAVEGQLLPLDDPSVLLGPVDEPDVPMDDILSFVSRQDSIPPQNVPSPLPQADPQGDLFRMMERADAFNREISALRQSPVRTSEPLWQSWTPSLPDTSAHESLSSSFNAGASFGEEHLLLRNRLSAVVEQPDEPPSRPDLGIGGETFGDRRRRLSTYERDAARQGDIIGRSRARQELLDQLLADSVHTNEPETSPPHISSPRRSPLHQRLEMSARVASPRAPPAPSRRLSPPSRSAGLSELHSFVDGFWRRENDRDIQDQFERTMRDTEAHSERVADFLAESGPSRSSFSTLRGALDERHINDRTHPRRGHRPPSRPQPNPAPRITQMAPRQPAAEPEPSATTSHWTTWEPVPTNPPSSSDYLSMSLPSSTTPQQAHYDSYGFYYFDDLSEASGPLPMPQPTRTRAESYLEASRDRSVGLSNLRHRARPPQRTPTPPPSPPSPRIQSTEPSFSYRSEVDGDRRTRPSSQRRPYDYLFHGTFTPRTPTDDAMLQSFTDHLQPPNYPPPPALPSVSSSEPSHPDPAPQPRQYHYGNFDLSAYREGPFRATLARSMALQGQSTNTRERASPSRTETREHGLRREYFLSLSSSEEDDDGPLIFSERTARQMIERMERSAHRRAVRLRGVPPQAGPPVTSAMPQASDDNEPEQLHLRTFDEVHSSDLPSRPPPLFRRVREHSAPQNQIERLRELVTRPTVTPPPPTRHRTLLERERAPSHLHGTRDNEPSTRSSGLDRWEQRLDTVRRVPARRAGGPDMPSSTLASSLASRLTGNANEGPSLASARQRAAGRAFAYRPPSPPSNPRPTEGRTEQRAPLNGRFARARGLASHFPPDMVWVDFPSARLPPYGRRRNIGDYIRDEDMDMSYEGLLSLSTILGDVKPRGTPADIISSLPKGTYGDWVRPGVTEERCPICLDDYDAKDACLRVPACSHWFHEGCLQQWLKTARTCPVCRGRVTKPRSGENSAPAAGASGSNNRNDDRDDDDDSDRDGARTPRHWTPFRPPWRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHN1</accession>
    <name>A0A4Q9PHN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_938696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145223">
        <property type="protein sequence ID" value="TBU53161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13486" checksum="86EE83421656ACF6" modified="2019-07-31" version="1">MLPSSAYPTSSASATTLSSRLPVHTTPQTAAQSPCPPRLQTRPSLCSISTTSLPLPVDPPQSFASPPSLQNPQRNVQSRLMPTYIFLPFPAPSLLHHFLPFPFSPSTTPRLYPTPIQRPALRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHW5</accession>
    <name>A0A4Q9PHW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_981142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145215">
        <property type="protein sequence ID" value="TBU53411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHW5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHW5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45494" checksum="527FDB3925A596AD" modified="2019-07-31" version="1">MDYVIQTLHIACALSQSANIPGLDAVVKAGLKLAEMVQETREVQDQCSLLAERAAKYSAAVYCQLTSGTFTLDGVTATRYIDDLIHTLSAIEALMIRRKNAGFVRAFWYRTKAAKEVKTLNGQLDDAFRVFDIQSSIHANQQILTLLQCTEHLLQHAENAEHTQAALLYGNRRIHAGVKEILQRVRVDATHDGTLRLYGREDLELVEELETENTGVMPGEQPVTRFRARICETGREVTVRRFPRPGRKFRDAIDTVKKIWHPNVVHAIGYSREDPEIAFIVNSGVYTHTFNELGKTFHGIDKLLWTVNSTKQILAGLMYLKSVYEELEWPPDEDTQFIQAEKQVVVGADGRVLLDVSCYDLKQLPNTVSHDEGSFTKLEKLSKVHNSLSVIDHPMYNVYRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI36</accession>
    <name>A0A4Q9PI36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_937750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI36"/>
    <dbReference type="STRING" id="114155.A0A4Q9PI36"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="417"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="501"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="579" mass="64942" checksum="E3553ECB5659DB6A" modified="2019-07-31" version="1">MDSQDPWHLTVVRTRGLTFLRPEKSWRPIVSVSIVDRNRDHGLPHEVVLGCDGQNPNLRSGISISDVSLTTKLDVQVFHKSQTKKKHRKRNLVGSASVSLNEFLRKHPLPHPRPVEYDVRLSCPPPQHKSATIWAKQQHSATLTMRFAVPHREPPRSHESRPITPTTEHYETEPLLSDAPSSSRGLSETLVSNTPDERTDEMPWGKQPESDRLDGIVGLRRRRKKPKMRGFHVDSDSHAETSSGEESCYPKTPETEYFPPIYEDESGLKFREEGEGEVAAIFPRILPQHAGQGSVVSAQTSLSFMERCLYWISPYEELKEADAEGDCEKAEKVLGRMLTEWYVVGASLLALAGINAAVFGLAPGSLFVLDGFSLGSISIGAIAAGLGLVYDAWFLVLYSGASGAKFLRLAKDVYNKYIFFCLTCRLPMFCMAISIFSLMLFLLAVAWTAWPTAVLVMSFVAGFLLTSQFVIFGIHRLINLVVWVIRVSWRTVMKRRSSSMPSAYPEAQLGPQTSSGERERHRERERERGWEREPRIEMPIPCPSPAPVVASPEHLTAHPKMQMIWVDDRVGEHEGPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIH9</accession>
    <name>A0A4Q9PIH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_961987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIH9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="50"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="37741" checksum="93CEE8A7F3767CDB" modified="2019-07-31" version="1" fragment="single">MPSSLAVDTHILSLKAHGEDLETYVKRYRLPANPNAGGRKALSRNDSVTILLLHGLGCVKEQWEPTIERLFELEKAGPGLRQRPTICEVWSIECPDHGQSALLNETVLRGRVEPVMCRTYALTVLALFRSGLLAQSLKPRFVLVGQCGGAVTAVLSTMMFREPSGVPFTSIILINPWFYSAQLIKVNADARREASQYAEYSKTIPDIWRSREEALRYLKAEKYHRSWHPQVLEQFVKSGVTSLPSRAYPLETEGVTLVYPRTIERRAMQLLYEVQPMLQHLRHLGHRVPVHVAFGEIQSTATQEFQRAVSNEVESLASIRYLPRTGLRAIQQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIT3</accession>
    <name>A0A4Q9PIT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 2</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_828988</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku80 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIT3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIT3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="18" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="597"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="18">
        <location>
            <begin position="317"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="628"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="639"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="664"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU53979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="844" mass="95534" checksum="8DD33E1FEBD73321" modified="2019-07-31" version="1">MFLVDISPSMGKMREVEVPASSGGESEVIEMTNLEWSLQFVMLKIQEMVCPTRRSVTQIFNGRKTDKCGVILFGSEETNNMINDANGGYEHVAEYIPIAQPNSATLAKLAALEPSTVSGDPIDALIVAIETQDQYLGNKKTWTRKVVILTDGESPIEVEDWEATVNKMNALDISLTVVGVDFDDDDLPFHEEDKSNIKQKNEAFYRTFTSKLHAGVVGNCDYALQEISRPDVRQVKSTLMGTVLRIGDTQVRPEEAIEISVKTSKCTALARPKSWKRFGRRKPLAAGKDKEKHKDAMDEDEQTMTFVQLRMRTAYYLEQNKGSKAEEKKEKDDLKNLVKVQKEELVRGYKYGATFLPVADGGYPRLHTRKGIDICGFFQKKNFRRELEMGEVYYVWADPANPMQQVALSSIVQAMYEKGVMAIARWVSKDDMDPKMGVLYPSVFEEVDCLLWVQVCGSLTAMPFADDIRNFPFASLETLINKKGEVVTEHPYLPTNEQMDAMEQFVDAMDLSDAGEKDEEGNREPWFDTRLSYNPAIHRTKQALFHSAIVQDLNTHPLPPPHPELLKYMDPPRRVLKRARTAIEECKKTHKVREVPKKVARVRKDEHVRAPDEDEDMLLLDQKPARGSPSSSKNTQARSQYGSQTQTQTSPSRTQKKAAAMDVDSSETEEETEEEAEELLLDKQTPARKPDRDRGPLPTPAQMPGRIIGLSFPLEDFKKNISRGDVVTKAVEDLAWVIQEILTRPFSTRRYDELIECMQELRKVSLEEDEIEAWNTFIQDLRETCLEKEPGNKAFWDKVRQVGRPLSFISSPEASKAGGKSAMSESEAQKVCFLWIILAATFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ01</accession>
    <name>A0A4Q9PJ01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_106884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145198">
        <property type="protein sequence ID" value="TBU54059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ01"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="139" mass="14345" checksum="7C9F2F092452FD71" modified="2019-07-31" version="1">MPMLTPRPTPRPRTLLSKNSLSLSSPSPLPGPGEEEVPAGSPEHYGHLLAINSCSSSPPLLKSPARKPSSPSSPSSMTILLRLLHNARLRGAGTRSPRSNGESSSQGRTTGCADASPPRSPSWPGGARAGSTCATDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJU2</accession>
    <name>A0A4Q9PJU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_828140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJU2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJU2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032574">
        <property type="term" value="F:5'-3' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18038">
        <property type="entry name" value="DEXXQc_Helz-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049080">
        <property type="entry name" value="MOV-10-like_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026122">
        <property type="entry name" value="MOV-10/SDE3_DEXXQ/H-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418">
        <property type="entry name" value="CANCER/TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45418:SF1">
        <property type="entry name" value="CANCER_TESTIS ANTIGEN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13604">
        <property type="entry name" value="AAA_30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21634">
        <property type="entry name" value="MOV-10_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase MOV-10-like beta-barrel" evidence="9">
        <location>
            <begin position="317"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="8">
        <location>
            <begin position="641"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU54390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="929" mass="102645" checksum="B720FF32EF366A2B" modified="2019-07-31" version="1">MHCAVCDIQVQGPTTWAGHILGGPHSRKSAANGLAPDEVRPSPPPPTHFKECRLCREAVPSNRWGWHLALAAHKRRQEHALLRSTFERSEQDRQGVSVSHADGGLDFGVISLADASRGVQVDLSVTVAASRSSISGLRLEAVSLSGQPATMFSASTNTTTVTPRRTLRIPIRLRYEHRGLLQGRLEITFQGANGRSVLICRTLRAVVGEATERQSLKPVAPYVRRRRAPWHHGRPTVSGDRPPALVATAWVKKLTRANIPDDLANMIKTRPAEAVIGYVIQRYMQASATWSKANHTSGFQALLWIEEARAVEDLHLYDLTDVQFIKEGSLYTVRVDGLSEKRPSVVVGDTILVQEANTEADRTHEGFVHTVRQNDIRVSFHRSFNHMGKRYNVFFQLNRTPVRRQHQALCVATPANQRLLFPNATQAGLLRPLTATESPLALFNSLITNNPAQLQAIKSIVKLRPGMAPFVIFGPPGTGKTVTVVEAIRQILHLQPRARILACAPSNSAADILAERLTVFSPAEMTRCNAASRDPASVPAALVPYTHYAGDHYAIPSRQQLMDYRLTISTCGNASFAHNVGIPQGHYTHIIVDEAGQASEPEVLTAIKAMAGKNTIVILAGDPKQLGPVIRSSIARELGLARSYLERLIEMPLYNGPNSRGTSYTKLVKNYRSHGAILRYPNEKFYDGELEVCGPPAKINQFLGSPQLVSPRFPVVFHAISGTNEREASSPSYFNIDEASQVKAYIQAILGDTRYPVRPDDIAVVTQYHAQVLKIRKLLRDSGIQGVMVTSVENIQGQERPVILMSTVRSSTELLTYDAKFTLGFVSNPRRFNVAVTRAQALLIVVGDPTVLSIDPLWRGFMNYIYLHHGWRGALPTWDVNAPVKTEGDYAEDIREAAALEMNAFMERLQDGEDLEAEANVDREFTETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL23</accession>
    <name>A0A4Q9PL23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_722108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL23"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13710" checksum="98EE1D4CFE06EE9B" modified="2019-07-31" version="1">MRRRARLSQSNLTHIPGPSALSSCSSLSESSGQTHSNQPQILRVLKESRSNLMPISVCLVHSQCDTTAEIKEQAYSILRKSSQHSTVSYAPPCHMVSAQHENTTHLAQRALIYGRMGDHVSRTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL66</accession>
    <name>A0A4Q9PL66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_961220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL66"/>
    <dbReference type="OMA" id="NFEVYEH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU54866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="281" mass="30467" checksum="05F3792A99666A21" modified="2019-07-31" version="1">MTIWFITGASTGLGRALTEIVLEKGDTAIATVRRPELLSDLSAKYPAGRLLILKLDVSKPQEIIDAFAAAKEKFGRIDVVVNNAAQGTFGEVETVADADVRAMFETNFWGAANVSREAVKFFREVNPAGEGGRLLQISSITGLRGQGAMAYYSASKFALEGFSEGLASEIDPAWNIKITIVEPGGFDTPGLGKVTWAPAHVAYSNKELPGNVLRGIWEQFHPKGDARKGMEVVYKLAALEKPPLHFPLGKDAVGIVRSKTQSLLEDTEKYEPWNEGLERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLA2</accession>
    <name>A0A4Q9PLA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_722565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLA2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49280" checksum="6C8B626D83B5F829" modified="2019-07-31" version="1">MATPHVKVVFEVMMCGVKTQTNMSFDTIVNVLQYIGQSTPLPSIIGLDLPMTPQDFLDIDRYLCTSKGTLRELRLDMDVPVPGQYPCDRRQPVNAHSYPALVSLSVHGFVPTTLDSSFIHLTHLTLGDVYSQTPPLWRDQFLDAMKTWTSLKVLEIEEYNRVIQVPESPRLVTLPRLEILKIKDSPHWASCILPCLDLPGLRQLHTHRTFADLPWGGNMLFWVPPLGNAVTRLLHMIKGVQVEVAQDVYQPTTISTTGPDDRRVVLTASVLAPMTRWHQWQLEVLPSIMLAMANVFPQAAKFNITGDFATMGKKTWTDFLKTYPELSELHIRDVGHRDGRPLFLALNQSELGPDDRVLCPSLKYISMYGVAQSRELLQEMHNALLCRSDHNLVLDHLDLYPQILAEPDSDDVLEELRSDIEDAVAVFEYKALNSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM34</accession>
    <name>A0A4Q9PM34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_933940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM34"/>
    <dbReference type="STRING" id="114155.A0A4Q9PM34"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031934">
        <property type="term" value="C:mating-type region heterochromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031508">
        <property type="term" value="P:pericentric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF15">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="58"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="224"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="496"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="552"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU55280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="656" mass="71685" checksum="428FAD74F3B575DD" modified="2019-07-31" version="1" fragment="single">MIAQLSQLSDAAQPTAFHRFLRVLNDRRRLLRVYTQNIDALEEKSGLTFGVPELDVKRAKPRSSKGKAPALDSAETVSADLPQPDEPSTSRLPSPPVETPKCIPLHGTLQLMHCVTCTHSYPLRDYIDSLVSGTPPPCPQCTALEETRQLVGKRSRGVGKLRPSVVLYNEDHKDGEEVGNVVRKDLMGSSKGKGRAGADLLLVVGTSLRVPGTKRIVREFSKAVRSRHAAMNAPPDPPADEQTTSAHGLVTPTPSPRRSPAEDEEPPVRTIYLNLDFPVPTREWEGVFDVWIRGDAQTFARMVHEELEKEEQAKEAAKERKRKREEAAAESARLAEEQEEGEVIAQLEAASLPKKGKRRKEQVHSENDAGGESRVQPTKKRKVGNPALSAVSPPSSKKTEQKKEKGKKALSSRGRKEEEVQSSLPTPPTSRDDPTRLTIKLPPLHKRLVPEVVISTLPKVTRPVHIPGPFSSPLSSPPVSTCDSPPTVSKTSNVITPLSSPLTTPPLSICGDPSPYESPYDMSRLSSTLSQISSPPSSPPRPNQLPTPPRPTRTISGTTELSSPTSSMSSSPSPSPSKKRKTSSCPSPVGKFMGPRPGMRSSYAYGSRPFGVEDELYRFERVDDDEETGSPPSESRLPESYMRSRPAPTARRRVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM80</accession>
    <name>A0A4Q9PM80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_950874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM80"/>
    <dbReference type="STRING" id="114155.A0A4Q9PM80"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU55322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="642" mass="70424" checksum="9FB62D06BF461E13" modified="2019-07-31" version="1">MTAADPSGNPMPSGWLVETPMTLPHSATVVTPLEALLLSRRYLVSQATFCATILLVHVCASWVTEARHRKKLVVPEGEVSSVPRKEGRRTYLYILFTVSVTLWILCVRIALKEAKLGIWQSMSYFEVVASAMFFQFSLYICVRLAHRGFTFGELGLVAFGATVLFMELMNLTIAKLWPLTTPYIKTFRLPTPLLVFQIALIPGSLLTGFLLSPLLYLSRHIAQRPVRRLRYPQEKQKHRRLLALGFYVGTLVIVGGLIGLWSRWCLGGRDPWVYVVFWMLEGRNKWTRPALVAYWALLISISVAGWTRQLARSKRWRQMNVRGSIHIANVGMTETLVAPSSPRYGPVPGQSSFSAMMQGPTPQGVATNPAGQPGGIPAVAPVEPTDPALAGEGIAGYGIRLPNLPNLPNLPDLPNANFSHVATDLLDAADKHVPTLSVNARRKFFHALAVVMFVPGIAVDAAFTHLAFSGAFALFTFTEYVRYFALYPFGAAVHVFMNEFLDSKDGGTAILSHFYLLTGCANSVWFEGPSRLPQFTGTLVLGVGDALASIVGKRLGRYRWFAANPKTIEGSAGFVVSVSVCAWLLRVFGTVEVFSIPRFAMVAGLAGGLEAFSVQNDNLTLPLYMWAMVVLLDVVDQNGAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMA8</accession>
    <name>A0A4Q9PMA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_689350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMA8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="177" mass="18821" checksum="AAFCA622E2B09A43" modified="2019-07-31" version="1">MAGSHERRQRERSGGSRVLAALPQAVATRYPSAFYGTSSVRRGACQCTVLSRPEQRSAEPPRCLFHGASQHLQYAVANQDFAFESASPIQGKGALPGDGTQFSSVGPTSLSRKSHSQRKSRDPNLVVLTVIASSSRPPSLPSSPRLFSAGIPLGRGLPIRIKKPDCSSAAQPQGELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMF2</accession>
    <name>A0A4Q9PMF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_960857</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145169">
        <property type="protein sequence ID" value="TBU55407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMF2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMF2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000003">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF16">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE TYPE III, ISOFORM Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" evidence="5 6">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="512" mass="56668" checksum="7D2F76CB8BAB48F0" modified="2019-07-31" version="1">MASAYTPLEDIPKIRDTARRAFFSGKAQSLAFRKEQMVQVGYLLKDNEDRLKDAIKTDLGRHPLESELFDFGPVYKEIRGAYDNLDKWSRSQNIDFNINWFALGPKLKPEPKGVVLIIAPFNLPLFLTLSPLVSAIAAGNAVCIKPSEQNPTVNAVLTELLPKYLDPELYHIINGGIAETSKILEYKWDHILYIGGSRVGRIVATAAAKHLTPVTLELGGKNPVVLDPKVDIKLAARRLLWGRFANAGQICTCPDYLLVPREIMEPLVVAMKETYQTFYPDGPEASDSFARIVSEDATKRIQSLLGETRGTVILGGQVDVPKKYVAPTVVANVDGDDALMREEIFGPVLMLVPVQDVDEAIAFIQAREYPLVVYVFSPDKKFQQKVFTSTKSGAALANDTVMSPAVPGFPVGGVGGSGYGYYAARQAFEEFSHWRVTLDNPSWVDKFVLGFRFPPYQPGYKTYTSMLYASLPPRPKKAGPVQKRWALWIFGAAVGAASILLTMAWPHLQLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMH5</accession>
    <name>A0A4Q9PMH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_684534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMH5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMH5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="662"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="746" mass="83405" checksum="FFF6A72FC7ABDB92" modified="2019-07-31" version="1">MHRASLNSQPGLHLQPYLHLHSRSSARPREGHGHSRPSRRQSVMNTFWDFVDWLLPPVRIVDDLADGPSDSSYRRPSHHHSSHSSRRLSGKDQDKDRERDRDRERDRDRERDRRREREKEERRHSRERERTRDRTRQKEGRASSEREKEREQLRQRVQALEHENESLLEQLRSTREELSKLSTAVFPSPNTLTPQSLTASYPASPPDALGLVHPILPAQALARSPSPIPSTSPTSSTYPSVLQHSAEAALADPKRLRLLYTSLRATYSDARQTILSQAEELASLKGFLSKTDDWSGAQLLQALADLNSEIIQLSASVAEEFATNLRVDTRVPIVAKERDREIVRPALGREMTKLLEEREHAQDPTLVQFALQAWEVWCVTRVMDAFCYGLPKDVDESLRRIFDRMQREEPQPTTSRWRALTYKHARSLLTRPTDASEPSSPDTVTPSPFNSAPSTIASASSLPPPLLSLTEANLRGVLAILALAGCTDARGLHRDPLRARYGSALSRISARAERISSVVKEGVLSGMFEVVWCRPCRGGSTSKAKRSSSTRRASSVPAEGAKVQNPLDINIEEIGANRGKGKEREWVKEVERARKGVDDDDYDEERTQTGERDENGAQIGDQMFDWKTMENVYAGHCNERCRVLCTVELGLAFSRRLPEEEKEESIDGDGMVVSNGGTGSGSRPTSRISAMSSLSRPVSMGGVGLDGVGSGNVSLSSNGQTVDANRMVRNLLLKPKVLLESVVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMR2</accession>
    <name>A0A4Q9PMR2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_825560</name>
        <name evidence="5" type="ORF">BD311DRAFT_673691</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143501">
        <property type="protein sequence ID" value="TBU23558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMR2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMR2"/>
    <dbReference type="OMA" id="LCLNCCN"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="10"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="184"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="265"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU23558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="436" mass="47654" checksum="AF357AFEFFE88E29" modified="2019-07-31" version="1">MITLSPGCLCDVCAEEYGPHNLPHSIPCGHVLCLNCCNNIIKKTPARLAPACPFCRVQFASDNIRLIRIDYGSGWSTPVRSPKHPTIETPSIDVGEDDVLLLNPGTLKTRAEARRLESKVAQVAAKKCSVEEVTTLHKELQDWLTSDKVDEQTSSLQLSAALLRAILVNHVAHSEATRVAKAVESHLRERLEHADMEKEKLEAELRSLRAQYSQKAQELQTLRAEVNRAKIKSVASTLGVPATPPPREMSSTPNPGMITPPRPQSVSTASAGSRSGATSPTSPTRTSYTPSFPSPLARHPAPSLHARTTSLHVGQRSMTPSVRSGTPLVSGADIARPATIPPKTRRMSMSSTPTPSKMSRSTSSSDEKEKEKRRIVDDREKDERRVPVIQRWIPSADALSRSPPTGRPEKFESGLHSTLTRPPIMRYKTPLSNASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNF3</accession>
    <name>A0A4Q9PNF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_932813</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNF3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNF3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="active site" evidence="10">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU55809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="474" mass="53477" checksum="807561308F765517" modified="2019-07-31" version="1">MGSAPSKATQPAPEAESHLSEKTLLQSFSDVRISVPLSKDGALRLDHVDSWESAVAQREAVIATPHVFNLELDFKTGPITDQKDTGRCWVFASTNVLRYNVQKKLNLEELQLSQSYLFFWDKLNKANYYLELSIELAELPVDDRLIQYLAKSLISDGGQWDMAVNLFDTYGVVPQPIYPESIHSSLSRPLNIILKTKLREHALILRALKATLRSNPALSDAAILATLRAKKEELLKEVYVVLSATLGAAPKPDEAFTWDYYDKSGKAGSWTGTPKEFYRAFAYDKYLPAESFSLIHDPRNEYGKLYTINKLGNIWGARPVLYVNTQIDNLKQAVVRQIKAGHPVFFGCDVGKFSNDPLGIMDQELFEYEAAFDITFGLSKADRLRTLESQMTHAMVISGVHLDKEGNPVRYKVENSWGPNEGNKGYFVMSDRWFEEWVYQVVIPKQLAPKDLVKVFEGEERVVLPAWDPMGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNG4</accession>
    <name>A0A4Q9PNG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_933130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNG4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="12147" checksum="D496BD1803052D29" modified="2019-07-31" version="1">MTCGTHHNLFNRLAWHSWWTRGYLGYSERFRLLELVSAMLERCKLIKLERRMGCGLYVSYLCVAKRAQQVVRQLAKVINTATDSEALATTALFCSALTAAQLHRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP59</accession>
    <name>A0A4Q9PP59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_855603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP59"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="175"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="309"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="441"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="799" mass="92027" checksum="EAE47C249B171F81" modified="2019-07-31" version="1">MAPDPEPGESPAKPYNLSSWEWALENLDLSEYRLKSMQDMARLFLKADSPIEFLDAFLPYPSTAPKRKPRKRNPFESLVNADKELETDVVAQFRNVVALKKLCPKMVFTTSERRPDPKNMDGTGQKVDAAFFRPQDAPTDGRPHWSSQVVPAEFKSRKKGDIYDPFDDKGIDFESQAEKRKEVRAQIVTYSELVFEHQHRVFVIMLLVMGRRYRLLRWDRAGTIVTPSVDYYENPDDLCEFLWRISHLDDEALGIDPTAIRLEGDDFDELDTIAQRVVNEVDETPRPLEGETFPESFHYKYVRKMFEESIRDRDRPRYKLQIPSGDGVDHFLVGKAAVVTPGMAGRGTQCWVAWHCEGSRFVWLKDSWRVSFEDIEKEGDILARLNHVKIPGVPTLVCHGDIGNQTTLTADWWKHKNPRAPVAESPTATSAPPTVPDTVVEVGMPLKKFLFGRQLASIVLDCIGAHFDAASHKKLRVRVLHRDVSDQNIIIYPKITRSSEGVRSLVWGGLLTDWEISKPVIERNIQPKARQPQRSGRWQFMSVYLLMNTLRRVKIEDELESFFHILVYYAVRYLKSTLLTDDDAAHFLEKCYDCFTVHNNRIICGAQKWAIVMQKTAGGLFFDHPMYNSTLPITFASKGLDVIVHRFLLCISARYKILAWNEWLEKHPNHPAHPQHRDRFQTPPPSKRRRVEGDSSASDAPRRNREDDDGPTPGMRMPDIPTPEDRILADRLTNHPYMIAQIRNTTSKVSFWKEDRLHDRVPPDYKCHYPLYETLPEPQTFPEPQTLPEPQTTSVADSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPM3</accession>
    <name>A0A4Q9PPM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_1025807</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPM3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPM3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051982">
        <property type="entry name" value="CiliaryAsmbly_MitoImport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984">
        <property type="entry name" value="RNA (RNA) POLYMERASE II ASSOCIATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45984:SF1">
        <property type="entry name" value="SPAG1 AXONEMAL DYNEIN ASSEMBLY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="162"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU56104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="566" mass="63094" checksum="76651B76155B9E7C" modified="2019-07-31" version="1">MQYSNRIKPVHFRPFLARWGVPWDHGSYFRTTTALNPAGIPAPLEEHALLPSVSMKSLHVKGAPRAHAVYLPTAGSHIESHVFAPDRLSGEEAEESPAVLASVGQGYLGYVGDVNGEKGSTCLILEMCGVKIQPGDLGERTHSTGLTVNPDGTMVPIVETETEIPVPPPPPPRAPRPRDTEVATRAEAREKVRKDKCTRADALKNEGNDLFKKEKWAEAAEKYRAAALLAGPQPVYLSNLAACFLKMELWELADSAATRALVHDPKHIKALYRRALARKGSGHAEEAFADLQRLLSIDRSNVPARKEAENLREIHGISPTKTPATNDQDSALEIEDESDSEDFAHPGTGIACRYYNTRDTGCRNGKKCRFRHAPDPKSIRDELGRNVCVYWLLGHCRFAAEGKCVYAHDATYLPARGWWTDTARLERMRAEFDDAIKAQPLNLGAGNVSESILAEAFVPLPWRKDFWAVASYEDAMREREEDSENYEDSDGYDSEEGRWDTGFGLTDAEVEELWTQGIKPWEIESYVSIVLYGCLLSDGVLKDPVMHVQDELMRIRSVLYNNSSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPQ4</accession>
    <name>A0A4Q9PPQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_630277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPQ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="224" mass="25147" checksum="7A6A1C2EEF39DC0F" modified="2019-07-31" version="1">MLCIDQAIPSDSLLPIPYDRIDICCHHSLAYATLPSSFPDDAFRHVLSSAKAILTCLVRKINHMLASVNCARMLRRRHPLRPSSTTACYYSPQTGDSPQQDRLLVSSCYSGAARRPTSMFTTIRRSSAGWFDFRRRSMSGSQCPVQELPAPQFVGTCQSSYSIENGTSHSKQSAMTQACSLDASGEYLSMRQDALVHTRLCMLQTRPDDKHLCFRRIRLITSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQL7</accession>
    <name>A0A4Q9PQL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase cytochrome b560 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_931089</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQL7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQL7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000011">
        <property type="entry name" value="Succinate dehydrogenase cytochrome b560 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19137" checksum="54B3389E518A6865" modified="2019-07-31" version="1">MLAHRALGLGPALRQAALRPRNVARNPALHNIVAKRSVQTESLPPSAAQEILNKQRLRRPSSPHFTIYQPQLTWLGSIANRVTGAGLSVLLYGYALAYLVAPDTFSSVNVVDFIHGLPEGVKYAGKAILAAPFAFHSWNGLRHLSWDAGKFLTLKGAYSSGYAVLGLTAVSTVGLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQR9</accession>
    <name>A0A4Q9PQR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_823125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQR9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12275" checksum="9EE8E60AA4D7E18E" modified="2019-07-31" version="1">MSNCAHVPASFGGRRWKALECAGVRTRKEVDGSATLVVPHMDSNYQTQPQEEHSQMPMQSSALFPVATQFPHVYATQPTSVFDGPVVVMPVSHYLGAITPRAACHVAEQHGCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR77</accession>
    <name>A0A4Q9PR77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_822966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR77"/>
    <dbReference type="STRING" id="114155.A0A4Q9PR77"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="320" mass="35546" checksum="E3824E07F7760D1A" modified="2019-07-31" version="1">MADSDIAATILEHDSFAASNYTGYATFALILYEYLITVGVEVELFWRKDITGASVLFFTNRYVVLLYNLSLLRDLWPFTLHVSCYCAQWANGTRAVEILCYAYTSSAFSALRVFALTDRNWILGLTVLLLSVGPVAINFADFHWSSIAIDPVWGCEQANAESPALSTKFTVISRSSLIVADLIVIVVTWLATYKTTKLARAAGHKSRMTLSVLLLRDGMVYFLVLLTMNVMHLAFSTSSVLINVGNGNVSDIIQVIEPMNAILVWRFMLDLQAARYQTMDLSTIVVTQQASTLYFDRVIGSIGEAVVPDALDTEEQKDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR94</accession>
    <name>A0A4Q9PR94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_930477</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR94"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="555"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="622"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU56890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="769" mass="86702" checksum="ED3C273BA7E7DE28" modified="2019-07-31" version="1">MAHNAESSERNSTSAASIEEKVDVEKAHIPKVQDIIAEFDDPNIDKDAVFLEDDSPYPEVRSAVANTDDPTMPVSSLRVWVIGLIWAIIIPGMNQFFFFRFPAVNVTGIVAQLISFPVGRAWAKFMPNYKIFGIPLNPGPFNVKEHVLITIMASVGAGSAYATDIVAVQRVYYNQIYNFSYQWMVVMSTQLIGFSIGGIARRFLVQPPSMIWPANLVTCALFNTLHQNVYAGMGNRGGMSREKFFFIAFACSTCWYFFPGYIFQALSFFNWVCWIAPNNVVVNQLFGYSSGLGMSLITFDWAQIAYIGSPLATPWWAEANIAAGFVFFFWLIVPILYYTNVWFSQFMPISSRTSFDRFGQSYDVSKIINDDTTLNVAKYEAYSPLFLSTTFALSYGLSFASITATLMHTFLYFRKQIWVQSRRSMSEQPDIHARLMSKYPQVPEWWYATIFLTMFVFGIISIEVWHTQFPVWAFVLALIISFVYTIPIGMIQAITNQQIGLNVITELIIGYALPGRPIAMMMFKTWGYITMAQALTFTSDFKLGHYMKIPPRPMFWAQVVATIIAGTVQLGVQAWMFTNIPDICTPNQSNGFICPSTQVFGTASIIWGVIGPARQFSKGQIYYGLVFFFLLGAVAPVAGWLITLKWPNSFFKYVNFPVIFSGTGAIPPATAFNYVPWSIVGFTFNYVIRRRHFSWWTKYNYVLSAALDSGVAVSAILIFFMLQYPDNGNIGKHTIQTWWGNTVFFNNADGASAPLKVLPPGGPFGPTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU13</accession>
    <name>A0A4Q9PU13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_820425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU13"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="384" mass="41360" checksum="61638779951F45EA" modified="2019-07-31" version="1">MNAVALHANLVSMTAGAADTRWASLRAQAEAFRGDAFRAKLQQEARIKPARQCEADKLQAKELEAVKFVAPRRFVAPRPRWSLSRILSWQEQDELEAPSKASLDEASPTRTVSGFYRMQSVPPQSGVAHNVHQYAGRGGIIGKLLLAAGSRRWENEDSNEAPAWPPASELIACPPNWGKARATDAAVGRAVVLHPVSRSDDGYFPPPGLHAPALGLNLPRATLRSTVSSSHFIGSDGTEWPIPPTECMQASSPSLSPVASDDEPFTTEGDEVHTPSCSPACSSVASSLPRTPAHKGGSLAQTTKGDCGSRWGVIGEGRPVLVCPQTPLLWSRELVLDSPISSWVADLESQVGSRYNSEFEWSSGSEYDSEEEVWSDVEIASNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVC8</accession>
    <name>A0A4Q9PVC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_475594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVC8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="414" mass="46452" checksum="B048D779D3B36FBB" modified="2019-07-31" version="1">MRMAGLTSRSDEWGTENDSSDQSQKRNTIDQLPEDVLLLIFNCLDARETLICKQVCHTFARLVGTDLCLQYNIELAQNGMIDGPPSTMCIAERLAKLRAYATRARRGEFTCRRAFCIEAGDSFDSHYILCRGSSHTYALHEPGEGETMIYCPPSFTPGHGNGRWLPAFQAKTTYTVAVDVQQDLLVATQYATEASEDLKIHLRKLNYPESSHPDAAAPFLHTSTPYPLEFPTSKGMWGTQICGDYLAWIHVCQRDSVATEIEVWNWKTGGRVWHHDFSEDVSFAFIDHSQIVVSAHSWDVRELLVYRISQPSNPSPSEPHSASGKSLHPTLQPVLAMMLPRRTAEAKVHESCIPSAPRASVPFWPDPGLATIAVDLEMDEEWSEDRTRPSLFALSTFRNLLARHYEPNKAQGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWW0</accession>
    <name>A0A4Q9PWW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cullin-4B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1012661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the cullin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWW0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWW0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="7">
        <location>
            <begin position="475"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="434"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="832" mass="94073" checksum="BDBD81C7FCD09045" modified="2019-07-31" version="1">MTDVYSLFTFPTTSRGFSALPSQPQAFPSTKDSSRSASPPRKIARLDGASDAHSASALSSRAGVAEPADKRGPIVLRVVGPSIQPTPDGVSNEEYGLVRRTIKILLDPEEKSPLPATYDRISRACRAVVNEAGRGEGLYDFLKMELERRVSKMEEKLGGEPRKSVDWLVPFTETCEWFEKQVGLLQSLLAYLDTLYVAERGHLIGTKQLAYTMFTNTVVKSVRVTAAIMDGIADWLEWERTHKATHPLRSYLPKLVRHMRAHDLYVEIIETPYLNLTHTYYIKESNDLAEGNKLKADEFLEHVKRRSAEERTRADEVLIESSVKSVHDTTDNALLAGRLQWLANDALDTLIKGRNDFQIKSMYELFAKVGGLKVLSAAFKVHVQKEVKGIVTDVANDEEMVPRLLEFKAFADKLVATCFVDAVPSPPGTAPSQSLASSSRTPTAAASPPAVQPNRDFAYGLIDAFQAGFKSRRIKPAEMIAKHLDKAMRRGQKGKRDEDFAAELDEVLALYRFTDDMDVFRTFYQRALAKRLLLGRSASDDFEKAVLKKLREQYDPDFGNGDKMFNDLDLSRELMTRFYKEKKVDESSSLHKLTAMVLQRSSWPFAARKTDILLPGWMQDDLSTFANYYKSKHQGRALDWDHALGTATLKARFKAGNKELSVSLYQAVILLLFNEEEELAYADIQEQTRLDDGELQRTLQSLACGKKRVLKKTPAGKEVNMTDTFLFNVDFTDPRHVVHINSIQSKETPEETKRTQSSIEADRKHALDAAIVRVMKGKKELTYEQLKTATIEAVKNHFVPEVSMIKKRIEGLVEQEYLRRDEEDQNRFFYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWY6</accession>
    <name>A0A4Q9PWY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_798770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWY6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18585" checksum="D2925E5FA8017D11" modified="2019-07-31" version="1" fragment="single">FSVRPFSPSETWSFPKPPTDNESGRVASAILSGSLRSSTQGSAFFTAEDAQTPEVEAKNPFADPENPFADLFEARPGSATTQDSTPAHFAPIEIVRRPFVPTVHDEIAVDVGDQVRVVRRFDDGWAVVENVTTGVRGLIPIDCLRAVEEELPAFLAKKRISSYVGPRASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX91</accession>
    <name>A0A4Q9PX91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_925708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX91"/>
    <dbReference type="STRING" id="114155.A0A4Q9PX91"/>
    <dbReference type="OMA" id="KFYVRFK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23797">
        <property type="entry name" value="UBCc_UBE2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000061">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="154"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20888" checksum="23287B6837E861B0" modified="2019-07-31" version="1">MSSPSKRRIETDVIKLLMSDYEVNLVNDSMQEFYVRFYGPAETPFAGGVWKIHVELPDQYPFKSPSIGFMNKIFHPNIDELSGSVCLDVINQTWSPMFDMINIFEVFLPQLLRYPNPNDPLNGEAAALLMRHPKEYDAKVKEYVQRFATKEAADAAFDKDDEDGEDEEMSDIGSISDDEAMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYR0</accession>
    <name>A0A4Q9PYR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_957965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYR0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9204" checksum="A06EC16E861D70F9" modified="2019-07-31" version="1">MLRVSITLITDGPHVIVRRPSYIASAVIAARNIIVMTMAGRGTRKRDCEARLRGSCWGIRCWRSGSTLHETCFVEPMVRRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZT9</accession>
    <name>A0A4Q9PZT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_361525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17444" checksum="E0BD7D99E12F8804" modified="2019-07-31" version="1">MEVKGTRRGSDRRIVVVALRAEAGFSPGSWLSPPNLKIRDAKMQTCIFLRPSPTLPSQQPVFNHSTRPSSPQNRFQISPGFVAAVLVARHRPRRPALIRPADVRSPRPDSPPARVISFRHHFPLRADAPESATLAPRSTPLLTQAAYCFFRYSMHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q075</accession>
    <name>A0A4Q9Q075_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q075"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q075"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="299" mass="31057" checksum="F2C9F0B3CE49810A" modified="2019-07-31" version="1">MTHDYFSVGSVFVMDAVHIPFGCSVWPSFWTKGPNWPAGGEIDIMELVNLAQDNQMTLHTTPGCTQPQGVMQLGKTSGTDCSAGTNSSEGCTVIETQSNNAGAAFASAGGGVWAAQFDVSGIFVWFWSRSSVPADVSNTSTSVDPSTWGTPSASWPSATCNITNFFTPQQLVIDITLCGDFAGQPTIYAQTCGGPVGNSSTCYLENVINNGTSQYADAYFEINYVKAYSLGDALDPTVSGTSVILSSISPTATSTISANGSGTSSGSTKNGAARSLGRQSRSLLVSVVLAAMVFALCMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0E5</accession>
    <name>A0A4Q9Q0E5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0E5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6357" checksum="74B8C332897B70B9" modified="2019-07-31" version="1">MQPRPDYVEYHHTAGTLCPKAKNVEAHLITGQNADCSCTMIYEKTYLQCYATHPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0W7</accession>
    <name>A0A4Q9Q0W7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_922113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0W7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="320" mass="34602" checksum="6B7BACE4133BC503" modified="2019-07-31" version="1">MADNSDVQVATEVFFGNCWTSATTALLAYDFVLTFPSEVTLFWKGGHLSGATLLCLLNRYITLASQVINNVSLPSSVESAFSVYIAAAVLQALQYLPWAAFSALRAYALCPDPYRWVISAGIFALSSVPIVTDLWVNLHGLSVVNDPVLGIIAITPVSASTITKLEVVTRSFLIASDLAVLCVTWFRTYETAKLSLRRLGKRSLACILLLDGTIYFLALLVLSILQMTFTLTGIGNKVDSPTSVIALLEEPLTSILISRFLIDLQKAQCKLAGSSRSVSLGEVAFQSQTSGSTGCFVGSLGAQLSCHEVDEEEDEMEHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q225</accession>
    <name>A0A4Q9Q225_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_904818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q225"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q225"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="94"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="433" mass="48658" checksum="201E4D97F140B7F1" modified="2019-07-31" version="1">MSFVFTLTTTPAAAFSSTSSGASPLNMNEPTSLVPLAHLDEKVVEMVSTQVNFGVIDYFIDMLVNTVARAVIASRYKAAMEMKTLLVMQHVCTFITCGALDTRTILTAIVYLSEIRLSAYDMGDRVCERLAIGALMLAHKSINEPSYRSEQWLQLVRMVFGQQFTIKDLTRIEREVLSALDWKVMPTNTAILAHYDVFMRYARRDREPSAVPKTAAVPARTERAERSYPVPEPAPATNPAAAIPDLMYPDYSSDGYSSDSDDSSEIITPPSAGPSAYASGHTHTGRVGATPSRKNRSSPYPYPRPSRRTSSQNHGSPVCERNDHYRVRRDASLIEAKVRYYAADHGTVLRESGSPRYVPYSPSQPWNRRDRYDPAPTPPPPSTTWKSYWPEDRPHAAHRRGEEHPWRRYQNWKSTMPGVSANDKWGTFGLFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q350</accession>
    <name>A0A4Q9Q350_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_920857</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q350"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="285" mass="30963" checksum="2D718EECA78EB677" modified="2019-07-31" version="1">MVSTRAAVCVILAGYLHGFVQAVTLSGTRSGSGIPGNSAAVMAPRARPSHCDPFHMAFDSSTNYPDFERDFSPLDGPHSYQLGSGGLSLFLDKPDGRITTKDGTNNKVAEGSTLNSTFTVLYGKVTYTFSGPAVPGVVTAAILIALESDEIDIELVGGRPTQWQTNTFAPALGENKPLYSTFSSLEDYPHGHKTVAESHAYTIDWNPERIVWSVDGSEVRTLRADDTRKNGSLHYPSHPARLQFGIWDASAPAGTSEWARGPIDWEKYPERMSAVFESIEVECPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3G5</accession>
    <name>A0A4Q9Q3G5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_919885</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3G5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9776" checksum="9567AA2892988917" modified="2019-07-31" version="1">MWLCVGGGVERLWVCSSCCSLVAFIRRQAIPSVGECVRHSGWNARACHSLCRSDSLLARTPISCTCLRRRLELVLNLISQRTTNLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4E0</accession>
    <name>A0A4Q9Q4E0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adipose-regulatory protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_990344</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4E0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4E0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="47204" checksum="18EF05971465E112" modified="2019-07-31" version="1">MDSQKQERDSREREQLRKQVADDTRGILSHLWPLQPVRLFIDLLWAVLRLFSPLAPHLVPLAVFSVILPLIILLSIASGFFVWKNIAVSWETDIYLQYGDGAIPHAEVALWNVAPNQPYDISLHLVVPANEANIALGNFMASLTLVGPSNSTIAEARKPAIVLPQYLAPWSFLYNRPGTVNLELPMLNDFVVGTSRATARVELGRRDQWRTLGEGHGRELAVLSGSVRGFVRKHGIRGLISRFPLLSALAASGVFFFILFIGLVACLMPAVEWHYPSEPDEPRQLEPEDKPRRRRRSRRPEYIERSESKSRPKTPTSARRTEGSGSRRQAVSAAIFLQLLLLTFMFCRAVTSRPRAKTTGAPQRTRRPQQPRGRLQPLSATQCPLSDGDYHDLLRATSLRHRSWFCALSIGTYSVITAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q656</accession>
    <name>A0A4Q9Q656_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
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</entry>
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                <person name="Grigoriev I.V."/>
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        </source>
    </evidence>
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    </evidence>
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</entry>
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    </evidence>
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    </evidence>
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</entry>
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            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010557">
        <property type="term" value="P:positive regulation of macromolecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="1028"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="447"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="572"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="687"/>
            <end position="895"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="925"/>
            <end position="961"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1269"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="33"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
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            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
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            <end position="267"/>
        </location>
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            <end position="295"/>
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            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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    </feature>
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            <end position="1280"/>
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            <begin position="1294"/>
            <end position="1314"/>
        </location>
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            <begin position="1315"/>
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        </location>
    </feature>
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        <location>
            <begin position="1411"/>
            <end position="1438"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1463" mass="158220" checksum="F2E82707E3528BFD" modified="2019-07-31" version="1">MNNGGDGQIPRQYSLNELVLSAANGAMSPEDEFAKRRQRIEAIKERLRSAEEQVEIEYMQYLEKREKLQAEVLRGQLAAQRLQELEGTVPVQTNTILPVAGPSTAWQSLPTYQVAPQSVQQYTELPSTARIVEVPSPQISPQVHPHAPVASSSRSDTIPAQTYSQTHKPSLHLPPPSFAASSQPAPVSQPVTDWTAYGADPKVMSQQPLGPHLQRSSYRPVQWPASNASYHQSQTYNYASQRPSSAPLVPPVPHSSQYKVTQSSSSVPQAGHVASSGMHSVGSSATPAARTSTQAIVDGASHARQAHNSDVSHTDQTSPSESAQHYPTLPSSIPPHHQRMLFEYLERLDDPIKRAIMVLVLMMAERREKGRQKTAEERVLEARVGPAIIRSAQTIADAWKMHDASQIQRLFSDYIQWLNSRRQARTAAGEAANVEQSQPSQFVQLDPAMSASSRAGVPPAPSTGARAQQASVPLPAVAEPSPFTSSSTHTNATPASTSTLRPTSEPSMATTSRIVPADRLRPFPWYRSRDPNAPVPFSDDNGQVYWLPPHAVPQSKPPVPGPSTLPIPKTLPRTTAFPQRRPASEARQSALWTPEKADKSRLAQDIMRSLGRPKETPSTTSTGKRRASLTPSASPTTIAKRPRLESEVETRLPIVPASDVQPYATIEVVAPASEQGAESPVAVAVVEPIPPDPAPPQADEPMERDVEAAEKAVSDIPEAGRAQSIPSSDGALDLVQDMLVAPPDTDPAAPPSSDPYRGLSYSPDEVVGPVEPLGGLGAQELHNLPSTAAPSAAPSSSHPSSVDGSRATPPPRSSSPYQREKTKEKIPLFLPSPSPTSTVDEHNRPDGSPTVDDVDMRSDASEPPRLPRHLKGKGRAVEDDDVTSETSSVMPGATSRVRRRVNRAYVLVPPLPQYAERKTALVSRSGSVASGSQNASASARSARSTQSASRSRGATASVHEGEGSIDELAAWHGGSLCMDESDCGKSVDQIYDMLVDEGMVAAEPQRDKEEVEAEAEAEQLSFTRLRQTPCSWSECGVILNSATTLQKHVALHADENEEWGTFTCRWNNCFSTHFVDKQSLVKHVQKHTKSPLWCAYEGCDTSYASPSELCRHQQSSKHQDGQLRRSCLPAPPPERMDPLPPLPDHVPAYMSVERRVGRHPISRERHQWLGPKVLENITSFKYTGRRSNAALPLRGSRRLAEKVAAAELAAVPPESAIDQIKRWIDDEYLDFADGYDASRRYRVWCADIPSGEITRMVDDGLVLWADGREDSDQRDQHAEADGPGVDGAGQEPAGEGDEDAEGEEDAEGEDDAEFEQEHEHEREPEEPPPPRVAGSSDEGAGLEGSPVRTEVSGGADGGGRPTPKPKLPLPRRSQVRLFSARPNRTDDSYDVEGVAGNTETDAEGRGERPSTPAPVPNSVPAAPSPNAPSSPPPISMPEPKPEEPVGSVWTAWPPAKEGSVGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8L0</accession>
    <name>A0A4Q9Q8L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_973622</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8L0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="45418" checksum="AFBF762B5355A532" modified="2019-07-31" version="1">MDGYEQVLNRFLRSESMRPWLGGVKSLSFNPEFADWDDKRGYRFFHDFAGRLPNLRYLIIDCADWTVAPHHPSTFRMFSQFPSVTYLEMYQTEFPSFNDFRRALSSLPSLSTLVLYNWNYRWFPLPHHELWQNASPQKRPVLRVFRIRFDLTQEELDVLFHWLLQTPSRLSIRDLAFSTLHLHKGPLRQPCIDFVDTVAPSVSTLRIDCREAISLRNFLDLHTLVVDMVPGQWEQLKGLLRDLPSRLRCLQLDSIPTLVLPAAGTLDHGLYNADSFTESHGHGVSQLDACLSLESLSELQTLELELSVQKLGTHLRREVESSRPYDLQTYFISVLEPFIEQPGKYLLWVIEDSVEDGIRNGLTSLRTPGREVELIMTTHRDCILERSPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8M3</accession>
    <name>A0A4Q9Q8M3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_955383</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU63815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8M3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8M3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="502" mass="55917" checksum="E7C32E0AF1DDD054" modified="2019-07-31" version="1">MSEDNVGTPLANSVGLVTQSPLAFALVLVGLYWAQKIIRGADSSRPPRTPYWIPWVGNAVEMGKDPDGFFSNMTKTLGPIFRVTTLGQERVFVTSPSLISQVYRDSQNFDFLAVRVEIGRQAFSIDDRVGTTPYMFDNYMPALHHILLPANIKSMTSTYLQSAHDTLVGAISSLDGASGPLKTIIIPPAYRAAAHAGFGPDFPAEKTWKGFTTFDESFHMINAGLPRFLFRKQFKAWEGVTDIIQAYLEEKKDEVHELSPFLQAALDGRQAGWTERDISIILATQLWALQANAIWAAYWLVAELLQQPDGLAPLVAELDAVRKQWQAAHPSTPFGPAFFDDMIVSNPKDVPLLSSAIQETLRYSSSTFSMRHVTAPVQLGGYELRPGDKVICVTRQTHLDEDIYPRANELDIRRYLDPPRPVKDGKPVPNHFMAFGGGVSMCEGRHFAMTELRLFVAILLTYATLEVDEGCTTRPELSRERMGLGIMHANGDMDVILRKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8T4</accession>
    <name>A0A4Q9Q8T4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_915094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8T4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8T4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="44"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="640" mass="70850" checksum="1DBC20EB11FBED18" modified="2019-07-31" version="1">MSLYPQTTTYTQMPYPAQGYGAAVPPQPSYYPPPPAPQPVFHLDPNMFRRDYMTRLANLTVNSRPIIQTLSLIAQDYSRYADVVVQCIEQHIRRVPPWMKLPSFYLLDAISKNVYDPYARHFTPIVVRLFLDTYEVVDQQTRSKMEEMLLTWRTASPTGRELFGVVSQLAIERHIWGGDSTQNAQSGSRDSGSISQAQVLSELEFVLGQKERLLLSSPHDDLTKHHIGILQQLRGMVQVGVPQRDLQAILTQLRALTTPSPPPAPAPQPYGALPSYSPPPSITGRVIAPQPPYQSQPAYPVNYEQPKQEAMDISRFLHAAAPVASTSTTPSVSMPDISGIFSALLKAGVVSASSTSTGAGASSKHEEPNEPADPERQARRAYRKLILSTKIKLTSSDVTRQRPRITDILYDRLPTQCKQCGYRFSDNSVGKKLFEEHLDMHFRQNRKATQAVGRGHSRSWFVSLEDWVSADSGDSKGKGRADGRTVSSKAVAAEEAAKREAELRAMFVVVPPGDEAKAISCPICKEPLKSEFLEDDEEWVWRNAVKKDDRIYHATCHAEAIASKSNLAVRLLGEGTSRSRSKTPEKATPPRAHATSNGELRQSETPTPSKLAGMKRKAEDDHATAVKHEGDGPQAKRVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8V4</accession>
    <name>A0A4Q9Q8V4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Cyclophilin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_840729</name>
        <name evidence="16" type="ORF">BD311DRAFT_746464</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8V4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8V4"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="15">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="14">
        <location>
            <begin position="280"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU34614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU63640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="526" mass="57016" checksum="D5A1A96D052B9FD9" modified="2019-07-31" version="1">MGHGNSNKLYVTHAEHSGMFGQHTASSAGHKAKQEAPHPGSRTPFDCCALTFQPFTNPVCARNPDGTGNVFELVSIIPWLKQHNNINPVTQEPLQPSDLITLHYARKPSGEIHDPISFKPFSEHSHIVAIATTGNVFLAESIKGGRDLVADVKFKKEDVITLQNPHGLPPASVPSRPTQPPSAEKADKGKAMAVKPAPAGPVAKAKAATPWNASPYSTGLPGASLTSTSVDPQTQSSQLLWDEEELMFDEFANPPKGKGKEKDVGKRRAYVRVITSLGGGGLNIELFCEKAPKTCYNFLQLAKAGKYNDCLFHRLVPGFMVQTGDPTGTGSGGESCWGTPFRDEYDLRNAAKHDSRGIVAMANKGPATNGSQFYITFRATPNLDKKHTVFGKLVGGEDVLDALEGLPVKPGTERPAKQVRITEVVIYQDPFEEYKRREEKKRARKAETQVTRAKEAEETAKDDINWFGVKVGTEKAAGAVGGGVGKYLNLNTNAKRPIEAVPSSSPAPLEESKKKRRIGFGDFEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAG8</accession>
    <name>A0A4Q9QAG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_465913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAG8"/>
    <dbReference type="OMA" id="DNEYATC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="486" mass="53860" checksum="425E282097AB10C9" modified="2019-07-31" version="1">MASSKVAALIDVIDCDVDHELNAEDGDAEFGGHEARQRLERQLVRKIDLRMSVLIVIYTLNYMDRNNIGAARLRGLEADLGLKGQEYATLLSILYVGYMIMQVPSNMVLNRLGKPSLYLPTCMVIWGVISILTGITTDFIGALLARFFLGFVEAAFTPGALFLLSKWYKRNELGTRIALLYCGLFLSNAFGGLLASGILDGMDGKLGQAAWRWLFYIEGSLTVFVALCAMFILPNFPSTTRWLSEEERRLAMTRMEEDVGVGDEGETEEGTRAGGLRLALGDWKVWWMVLATTSFNVALSFNAYFPTLSATMGFNLTVTLLLCAPPFMLGVIITFAISRHSDITGERFYHISLPILGSVAGFVIALSTMNTAARYVSLFLMAQSYAGFVVLYTWVSSSFPRPPSKRAVVFAVVNAFSQLGNIAGSYVWPSAWGPTYRKSYAICISTAGCTIAMCYIFKLHLAHLNRELEREEAKKGVKEKGFRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAH1</accession>
    <name>A0A4Q9QAH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_915276</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAH1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAH1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054694">
        <property type="entry name" value="Parkin-like_IBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22605">
        <property type="entry name" value="IBR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="410"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="414"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="346"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU64061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="629" mass="70254" checksum="450BFA7247C85CAD" modified="2019-07-31" version="1">MARSTFPKPSQMPDDTSSPSAIIQRLVSGETPEYVVTHPGRSQYSQTGGGVSACGLAALNCARIVLGLHSTGLGTTQLLEELMKRKFLEDILQPCLSWSSSDHLAVDEIHKVPIFRKSLKTVGSHYGQAGLPYFEGLMSNISQYTKQHSTSTCVIITRPPEIIACFCLSDVPAELFVIFDSHPRPHKHPHGAAFIFKNSVNSTAEYLATLLHYDERLLRDSTVQWQAQLLAHCSGDVFVARRGGSTSSQWGEMALEASLQVLKLQASVRTLEKRNEDLEEDKKRLNDEVAELEDQLLELDDEHEKLKARYEQLQALTQHRRSTSIPRSSPSDYRQQPLQSPLGLVPSSQRGTPAPTASSAHRPPQNGSATSQASDFHAADALASQLQRAYDEENQQLAQQLRHLKDIQPTFFDCGICFERHQDDHLARVMPCGHSYCRPCLRAYAVSKINEHRFPILCPSCVADRGRSEFGELDDFAIQQLGLGERQYEMFCELQLARFSTVIHCRRCLKTIFVDKAEYEEAQEIVCPLRGCGYAWCKACSQAIQIGGPKHSCDGSSELKDLMAQRGWKHCPGCQTPAEKIDGCNHMTCMSPGCNAHFCYLCGQLIVQSVLRNEIQSAVSRHYRRCVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAI4</accession>
    <name>A0A4Q9QAI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dynein heavy chain, cytoplasmic</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dynein heavy chain, cytosolic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_837967</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Consists of at least two heavy chains and a number of intermediate and light chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynein heavy chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QAI4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005858">
        <property type="term" value="C:axonemal dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048468">
        <property type="term" value="P:cell development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003006">
        <property type="term" value="P:developmental process involved in reproduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007097">
        <property type="term" value="P:nuclear migration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072384">
        <property type="term" value="P:organelle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048731">
        <property type="term" value="P:system development"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000122">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2620:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.130:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000005">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.30:FF:000001">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.180.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000517">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.1220:FF:000007">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.720:FF:000003">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.280:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.490.20:FF:000004">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000373">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000075">
        <property type="entry name" value="Dynein heavy chain, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1120:FF:000013">
        <property type="entry name" value="Dynein heavy chain-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46532">
        <property type="entry name" value="MALE FERTILITY FACTOR KL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0243">Dynein</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="738"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1038"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1411"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="1753"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="3171"/>
            <end position="3191"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="439"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2015"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="2234"/>
            <end position="2310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="3177"/>
            <end position="3191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00033439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU64667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="3449" mass="392346" checksum="F5E261712288891F" modified="2019-07-31" version="1">MELLAPSNSSTAAAVTFITFVQDLKRKTKTWGPMIEVCASGEKTLERFRYQFPDDWLYSDQLRGEWSAFNEILKRKNDSIQEQLAGLQLKIVAEDKIVENKINDIIAEWEQTRPVQGSMRADTALNTINIFEGKLTRVQDDYELVCKAKEALDLELIRHTRLEPVFEELRDLKAVWTALSGVWNQIGELREMAWATVQPRKLRQQLDGLLSSTKEMPTRMRQYAAFEYVQDVLRGLLKANTLIGELKSEALKDRHWKQLFKVLRVPSQISLPLMTLGHVYDMDLRKNENLIKEVIIQAQGEMALEEYIRQVKETWTNYTLDLVNYQNKCRLIRGWDDLFNKCSENLNSLTAMKLSPYYKVFEEEAGSWEEKLNRIHVLFDVWIDVQRQWVYLEGIFSGSADIKHLLPVESGRFQNINTEFLAVMKKVYKSPFVIDVMNIQGIQKSLERLAEMLNKIQKALGEYLERERASFPRFYFVGDEDLLEIIGNSKEILRIMKHLKKMFAGISTIMLDDDLTQIQGMASREGEEVQFKTPILLKDYPKINDWLSKLEAEMRVSLAELLCDAVGELQSFYGSVTPLPKDQFMAWLEKYPAQLVTLAIQVAWTASIESTLESSQSLEGPLDTVRQGLDLLADVVLTELTPVTRRKCEHLITELVHQRDVTRQLIQQNVSDNRAFTWLYQMRFYLNRSIENPLERLAIRVADASFPYGWEYLGVPDRLVQTPLTDRCYLTLTQALDNQLGGAPFGPAGTGKTESVKALGVQLGRFVLVFCCDETFDFQAMGRIFVGLCQVGAWGCFDEFNRLEERILSAVSQQVQSIQQGLATLVKNPNTEIELVGKNVKLNKNMGIFITTNPNYAGRSQLPPNLTKLFRPMAMTRPDRELIAQVMLFSQGFRTAESLASKIVPFFNLCDEQLSPQPHYDFGLRALKAVLASAGILKRERLLAATHEGADAAGLSDAASEQVILIQSVTETIVPKLVADDVPLLTSLLADVFPGVDYVPVDLDALRQKIGEVCSERRLVEGERWINKILQLYQIQKIQHGLMMVGPSGSGKTNAWQVLLAALERLDGIEGVSYVIDPKAMHKDALYGTLDPTTREWNDGLFTHTLRKIVDDVRGESGKRHWIIFDGDVDPEWVENLNSVLDDNKLLTLPNGERLNLPPNVRIMFEVEHLKYATLATVSRCGMIWFSEDVVEPAMVFRYYLETLSTVPLDAEDDEAVDLPGRRTDPNESAASPHLATQKQIATILEPFFGEGELIMSALQYAETIEHIMDFTVTRALNTLFSLINKTARNVIEYNIQHSDFPLSHERVEQYVTKRLLVNIIWAFSGDARLELRAELGDFLRKHTGVDLPPLIPGGSLLDFDVQVANGEWSGWQSRVPVIEIESHAVTASDVVVPTVDTVRHEEVLYSWLSEHKPLMLCGPPGSGKTMTLFSALRKLPDMEVVGLNFSSATVPELILKTFEQYCEYRKTPNGVILAPTQIGRWLVVFCDEINLPATDKYGTQRVISFIRQLVECGGYWRTSDMAWVKLERIQFVGACNPPTDPGRVPLSHRFLRHAPLVMVDYPGELSLKQIYGTYNRALLKVVPNLRAYAEPLTDAMVTLYLASQKRFTTDIQAHYVYSPRELTRWVRGIYEAIRPLEILSVEGLVRVWAHEALRLFQDRLVTEEEKRWTDEAIDNAAMEHFPTINRDEALSRPILFSNWTSKNYIPVDREVLREYTKARLRVFYEEELDVPLVLFNDVLDHVLRIDRVFRQVQGHLLLIGVSGSGKTTLSRFVAWMNGLSIFQIKVSNKYTGEDFDEDLRTVLRRAGCKGEKICFIMDESNVLDSGFLERMNTLLANAEVPGLFEGDEHAALMTACKEGSQRDGLMLDSHEELYRWFTQQVAKNLHVVFTMNPPENGLASRAATSPALFNRCVLDWFGDWSDQAFFQVGLEFTNTLDLDLQTYNPPSMFPIAYRDLSMPPTHRSAVVNALVHVHESMHHINQRLSRRQGRYNYVTPRHYLDFINHYVRLHNEKREELEEQQRHLHVGLDKLRETVEQVEELRKSLAIKRTQLEAKNSEANNKLKQMVADQQEAEQKKAASIEIQAALKEQDKNIKQRREVVMADLADAEPAVLDAQSAVSNIKRQHLQEVRTMANPPEAVKLAMESVCTILGHKIDSWRTVQGIIRRDDFIQRIVNFDTANQMTKQLRDLMKRDFLSRPSYNFETVQRASKACGPLVKWAIAQVRFSEILDKVEPLRNEVQSLEDQAEATKQQAAMMVTMIAELEKSIERYKEEYAGLIRETEAIKTEMERVESKVDRSMRLLESLSSEKVRWEDGSRTFDTEMGTIVGDVLLSAAFLAYAGFFDQQYREQMWQEWSSHLAEAGIKFKAELSLPEYLSTADDRLSWQSKSLPSDNLCTENAIMIKRYSRYPLIIDPTGQATTFLLNEYRDRKITVTSFLDEAFLKVLESALRFGNTLLIQDVEHLDPILNPVLNREIRRTGGRVLIRLGNQDIDFSPSFTMFLSTRDPSVEFSPDICSRVTFVNFTMTRSSLQSQSLDQVLKVERPDTERKRTDLMKMQGEFRLRLRTLEKLLLQALNESSGNILDDDKVINTLETLKREAAEITRKVEETDVVMKEVEEVTAEYLPLAQACSAVFFILEQLNLVNHFYQFSLRFFLDIFDYILHHNPNLQGVADYAKRRDILMNDLFVIVYKRTSRALLHRDHVMLAMLLAQVKLRGVEEINDELEFFLESGDGVVAGAGAIQTTILTPDQAQRVVTFAKQPMFKPVLTHLTEHEDEWIPFLESASPEQSVPSPWDPSTPAVEAIRNMIIIKCLRPDRLLQSTATFVRTVFQIDIASESAYDLGKIVTDEIQPATPLALVSVPGYDASYRVENLVQNSGSRCSSVAMGSQEGFTLADQAVALAARQGSWVLLKNVHLAPSWLGQLEKKLQTLNPHRNFRLFLTMEANPSIPVNILRQSRILMNEPPPGIKANLSDSLRNISSGRLTQGPAEKVRLYFLLAWFHAVVQERLRYVPLGWSKTYDFNDSDMAAAFTTIDTWLNSVAKGRANVDPAAIPWDAIRTLVKQSVYGGRVDSDFDQRIVDAFVDGLFTPHAYNVDFDLVPSVTGSQVLTVPDGTKLEHFMSWVQGLPDREPPSWLSLPPTAERVIAIAQGNELLGKLRKMRMLADDDDEATPAAGPSSQGQTSQQPAWMRNLHERCREWLQQLPANFQTLQKQSAEHSDPLYRLFFREGSIGSRLLSQVRKDLADVVKVCEGDLKQTNHLRTLMSSLTKGTIPTHWRRYKVHKAMGVSEWISNFARRLAQLDQIAQLDNLTNIEVWLGGLFFPEAYITATRQAVAHRKKWSLETLRLELDIEKVNDPGAFIVDGLVLEGAAWATDKLVLNDGETVRLGPSQVRWVQSEETAPNRVNLPVYLNGDRSDVMFTVDLPFDAAASALVATRAVCLTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAM3</accession>
    <name>A0A4Q9QAM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_913037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAM3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="68"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="223" mass="25913" checksum="65672D5A2A206708" modified="2019-07-31" version="1">MEQMTDSSSPILQVTRNAHHDHAFQWLPEDEVVLRTLLPSNVQSLARSKIDYHKEYTRRLSSTFNTGALVHLLLPTEMLMEIFSRIEPQSCHDIRILHVCRKWRSIILRTPAFWQAMLRLSDVMDDSCSSALDIQVANEILRLFAPRKIDVTVMFSSDLRPTILVPHLSRITPLAIYMEPDHIVEVFEALRSFRMVHLTRLVIEHEHDESTEDNFEISSAEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAS0</accession>
    <name>A0A4Q9QAS0_9APHY</name>
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        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_914509</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9QAS0"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="377" mass="43828" checksum="2982562F08BFABCE" modified="2019-07-31" version="1">MLDDVLAFSDPLSVPQEALEKLTKPEEWWRDRQAWLAERGYMLRPRYRPGWTPSWKAHPDVFPWKFEDYHGASNPHLMDAVSIPDNQLVVLKKVLKSFNPLEVEVVQYLSSEALRSDPRNHTVPILEIFSVPDDPEATVLVMPLMRQCDDPAWQTVGEIVAFLTQVFEGLQFMHELHVAHRDCVAQNIMYDPRRMYPHMFHPKDPDKSPDFKSKARHSNRTVCPVKYYFIDFGLSRRYNPEDGPPREHPIRGGDKSVPEFQSWKGDLVDPFPTDIYYVGNMIRTDILEKFEGVEFLAPLADDMTATDPIQRPTIQEVVRRFDALLKPLDNPILRSRLLLRGQPEDWKTRWLRDFGHSLRSFGYALLRKSAIPLPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBD0</accession>
    <name>A0A4Q9QBD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBD0"/>
    <dbReference type="OMA" id="CFDERAQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9633" checksum="314112F4F648605B" modified="2019-07-31" version="1">MTKPQKQRPKTSSASLNTARQSAAKQAVKKRVKAPSRISKDQVADATAQINIQFAQVQALYAQPKQTRDAAPSVLEADVQDLAAVMKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC43</accession>
    <name>A0A4Q9QC43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_911014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC43"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC43"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF51">
        <property type="entry name" value="SNF2-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="537"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="848"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1181" mass="134802" checksum="D315F236299143B4" modified="2019-07-31" version="1">MEDLYTALKNFLPVGVVTLRIDSPILGFSGRQQNSETAEDGWTPFPQSFRAVDVVDGEGFLETLEALDFLVRHRFVAATYLVHDAQARLFVRVYLIPWDLPGSSGKLRRRDEDTVLRPGRRRLKDLFPRIRQDRSLWDGQAASSSTPSFFWPKIADNRSLLDIYNDLPSPASEDLVGELPGLRSTLYPYQRRTVSTMMARETHADTIADPLYLALHGMDGRVFYLQPATFEIVTEPPRLSPVPGGILCEELGTGKTAMMLALILATLDDLSSPEAIYHEERVPMTPLAIRHFQTPSATAQREKLPKKGKAYRDIGVPSLTEIMLHQLRVCPNSLGLRNQQDVLEQRNLWEPLRANVPFYLHTEPRRDDVGWYQARSGSVSSPKVMYLTTATLVVVPDNLHMQWASEILKHCTDFLRVLVVKNKEELPDAPVLATDYDIILMSHSRFSKEARKKATEELYTMQPCQCKTLRNARVPRCKCSRLENVSPLLQIRWKRLVVDEGHNAAEKRTDYAIFTKLLSVERRWIVTGTPTTNLLGLNFGSGDELQYPDDDDEEEEESSASSDDRNEQRKWHRSEREDFRKLGTMFADFLLMNPFASNSKAFSTLVTDPIFEPEGPFPGDIQVLTQVMASVMVRHRIEDVEQDVRLPFLEHETILLDMDPYAVKTYNLIQATIAVNAVDSERKDQDYLFHPRNTVHLRHLVANISHVMFWHVVDEDLAERLTNAERCLKTLEQRNGSSADFTLIKDSIQHLRSAMSDPIWLALQAHYHCFHRVDKLSREIFNGWSMFSEAGRQACDPPLLPPMALIKIRAFLTQHPLKKVRDIVAMGQHVIEEERRWKEFEALHNQLKKKSSKDKRERRRKEDAANDSLASMKREAKEKKLEEVRLEYQAAAARLTASATGEEVAPSRPDSSQRTVASTLLKLSPMADVRIGNSTSTKLDYILNEVLTYGADEKFLIFSEFPATLSFIAEALDLVRVKYLEFSGKLKREHRQTIITTFETSDLYRVFLMELKHGARGLNLVSASRVIFCEPVWKADVESQAIKRVHRIGQSRRVMVKTLAIRHTAEEVIVARSKALKESKQEFTKEVTDDRTIRDFIEHPTFLPIPIADQVVKLDVPLFEFAPPPSMLPRDNTKSSSPQPSGVRVVEAKTVPSIPRRRVAVHVEISTQPPRKKQKRVAFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD48</accession>
    <name>A0A4Q9QD48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Neuraminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_17723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD48"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD48"/>
    <dbReference type="OMA" id="YTYYRIT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020282729" evidence="1">
        <location>
            <begin position="23"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="401" mass="41730" checksum="9B02A2CF0567D2D8" modified="2019-07-31" version="1">MARSILFALLTASSALFTLVSAAPSSDYSGGLVYRREVNFGHEVNWAETPTTHNARTLERRAGLVPHVPSANIVLSPNGGAYPRVTSLSDGSLLAVYTASSGGNKTLTVARSTDGGSTFGAWGTIATSPGDLDNGFLLQLPNGNVVAAFRNHDMSGSAYTYYRLTACVSTDGGRTWTFLSQIDQRAATATNNGLWEPFLRLSSSSALQVYYASENSGNDQDILVQTSTDNGATWSGTTTVAGATTTGRDGMPGCAQFHDGATKLMCVFETTEGHSGLFSVKSVVSTDDGKTWGTTRSEVFNPSGSNNNAGAPQLVATSDGNLVVSFMTDEDTSAHSWPKSGVAFKIVTGPPVATGNWGHKTTVTGPQSAWPGLYAKSDGSVLGCAGAPAGLICKDITFTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD59</accession>
    <name>A0A4Q9QD59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Galactose mutarotase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_298196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide lyase 8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD59"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016837">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on polysaccharides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.10">
        <property type="entry name" value="Polysaccharide lyase family 8-like, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038970">
        <property type="entry name" value="Lyase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011071">
        <property type="entry name" value="Lyase_8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012970">
        <property type="entry name" value="Lyase_8_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004103">
        <property type="entry name" value="Lyase_8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003159">
        <property type="entry name" value="Lyase_8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38481:SF1">
        <property type="entry name" value="HYALURONATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02278">
        <property type="entry name" value="Lyase_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02884">
        <property type="entry name" value="Lyase_8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08124">
        <property type="entry name" value="Lyase_8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49863">
        <property type="entry name" value="Hyaluronate lyase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020740749" evidence="5">
        <location>
            <begin position="27"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 8 N-terminal alpha-helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 central" evidence="6">
        <location>
            <begin position="472"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase family 8 C-terminal" evidence="7">
        <location>
            <begin position="735"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="837" mass="88480" checksum="2F87161440C405D4" modified="2019-07-31" version="1">MAMTLRMLVLTWGIALLPTLIPSAYSAAIPRGDPSIDLASDSTAAESAIIASMLANAFSPSGTTNSNAGSPTALNDNAASTSSSSPSQPLVSSTSQSSSSSSGSDGVQIMLQRRLPLIVEDVLGTPDVGNVSDISAWVSSLGDDGKWPSSEVDYTSGCDGQKANWPAELHWERVALMAAAWHGGVDGGDEFVNSSSLLDATSRAMDFWFKNDFTVEDCLGGKCDCSSSGFWNSNWFSNTIAIPKLVGETCLLIGADNLSDSQMGSCTHILNRSAATLRDGVPGIGKMTGANTLDIAKISVDLGLLTKNDSAITDAYTAAHKEVVVQNTAKTDGIRADGSFAQHGGILYNGNYGKDYANDVLALEIIAGGTKHSAQSSNSGTQSQQAFETLLDGDQWMMYRNAKTGVVHWDFSVLNRMISFPVADDQATGSININVSHIQQLGSEWNSPTLQAIASNVAAPGDNANVGNLTGNRMFYANDYMVQRGSGYVTTLKMFSSRTLNTECINDQNPFGFHLSDGTVYTYMEGTEYGDIAGAWDWNLIPGTTTNYAATKLDCGSTQFTSGEAFVGGASDGKVGAAAMRYKNPATGSLSFQKAWFFLDDDVQHVMVAAASTTSDQDHPVISVLDQKRLNGAVVVDGQEATRSGNFSGAASLWHDNVGYTFNKQSLSVNLGQREADWRPIGISKLANTAVNLFSAWLVHGSGSDLSVPVAYTAYPAVSQDDFAAKSAQTSLTTIQNDKSISAVFDETHQTAMFVFWDKDGGSATFTPSGKDAITVQSSGNSVVMYKLNDGTVTVSDPSQSQRTLHLSVTTGRAQARALDVDLPQGGEAGKSVTQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDK2</accession>
    <name>A0A4Q9QDK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_912309</name>
        <name evidence="13" type="ORF">BD311DRAFT_785932</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDK2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDK2"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02668">
        <property type="entry name" value="Peptidase_C19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01795">
        <property type="entry name" value="Ubl_USP48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033841">
        <property type="entry name" value="Pep_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006615">
        <property type="entry name" value="Pept_C19_DUSP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044743">
        <property type="entry name" value="Ubl_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF888">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51283">
        <property type="entry name" value="DUSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="165"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="DUSP" evidence="12">
        <location>
            <begin position="728"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="10">
        <location>
            <begin position="1048"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1001"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1124"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="850"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU32441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU65892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134257" checksum="C5C6A1A4D3E87285" modified="2019-07-31" version="1">MPPKRIRRASPGPSGLSAGERLKRAKLTGNVAYSAWGWVGTEVTDVAGISNEHRLATCGFSRNSNYSLCSNKHVDKRKTQSPPTPKVNGHVELEAAEEQAGDIIVISDDEGPTCSSKACKQNPYCLNYLGQGKWEDAEDAYEEYLKVYDIGENPMLDARDGQTPIGLKNLGATCYANAYLQVWFQDIPFRKGVYECQPAQDAQHPFEESPIFQLQVTFAAMQHSELSAFNPVKLVESLKLRASEQQDAQEFSKLFMAHLDTEFKKQQSPDLRSLIPDQFQGRLVYNTVCQHCHRRSGRDSDFLEIEVNLENNATLEERLTALLEPETLSGDNKYFCQQCDNLQDAKRFTELHDLPPVLHFSLLRFVYDFASMERRKSKQTILFPTCIDMDRFVGDEDTRKQCGQRHAKESKNLYALRGILLHKGASAYHGHYEAQVFDVKNQAWYQFNDETVTKIESLVPKLDAGKKGSKGSKKPATQPPKGRPPKKRRRIDDSDSEIEIVESSERSQRGEGSPAREGPEYISSKDAYMLVYARVDHPSRPGPCQPANGHASNGASQTDDRQVNPPPRALEVVNRLNAVHRKAREDYTKREREARERFDRIRSIVRDIYRTWNVESRDEECVVVSRQALEAWLSRHVAQPKASKTSPMTSPGPSKDAVPKAEETASSTSSEAGPSAVTIPVSDVVCSHGKLDPEKAHDMKVIKAAFHSRIAGEDDCLLSPRLTTQDVCATCVQRMFTEKLYQVEHPQLVSQFDDVVALEGDEDGYYISKAWLKDWRLARPKMHVEGATDPSPDAEEYLRDVVCEHGGLATNQAARRRISAEACAILQELFPNWRPPSTSTEPCAVCEALLHISKEDKREYRKQAEEEKARLKHMHDNALNGLTALLEDVPCAIVPSQFVRAWRQWVMRPGEVSRPETVDNSTFVCEHGQLAFNPNVPGDMDTSMAIVRLSDWSALKELYSAGPLIAIENTGGKYIHDLPVCLDCRLKRRTSFEMTEVTIRVLGPSDPTPTPQNYSDEPLPHSPTKPVQTTLHKYGKRQNEGSRKSKRIRQVREYGKRRRITITKAMSVKELRVMLSDELGIPVIFQRLFYRGHELNDSSATMLSLGILSNDLLDLKEESEDITILTDSDNEAPTGENGKKKRTEGQAFGGTLLGGNSLSSAPSSSQSLAPLSTACPACTYENGAADVACVMCETPLPNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFV0</accession>
    <name>A0A4Q9QFV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_986020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PIGX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFV0"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU66216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="25308" checksum="A108F2DC906DE010" modified="2019-07-31" version="1">MPLATFSSSLDAQGFHFTLSTIVNVSSRDDHCTFHLLLELDPHVYADQYELAQRPEYTSLVWGDADLERPVSAVHPDGSVLLVTTHKHVTLRAQATNFTVDVPLHARYGRPTETSGAAFHPITLKHPIGFFACIDDSKWVCRPIVVPELLKPYASYPGWPPLPLFLVKDSSPNEQLQLVIPVGVREDLAWVDVGTAITMTVMFFYLLFASIRTARRLAGNKSHAKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K551</accession>
    <name>A0A4V2K551_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_957544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V2K551"/>
    <dbReference type="OMA" id="EIMFDDR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="625"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="688"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1144"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="979"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="636"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1147"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="167"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU60723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1629" mass="184325" checksum="5586710C57067F9C" modified="2019-07-31" version="1">MAENIYSKGTRVWFPDKELGWISAEVTTVTRTDDTVKLVFVDERGKEIKVDTTVKAIKDGKEDLPPLRNPPLLETADDLATLSHLNEPSVLHTIRNRYAQHSIYTYSGIVLIAVNPFQRVALYGPEVIQAYNGRRRGELEPHLFAIAEDAYTAMSRDGTGQTIIVSGESGAGKTESAKYIMRYLASVDPPEKKNKARTKASLDESSEVERQILATNPVLEAFGNAKTTRNDNSSRFGKYIQILFDGEQEIVGARIRTYLLERSRVVFQPLTERNYHIFYQLCAGAPLKERKDLGLDTDVTKFQYLSQGGPTSTPIPGVDDEHEFQETQKALSTIGIGIEKQWAVFKLLAALLHLGNIKITQSRTDAAIDDTDPALQLSTRFLGIPLAEFKKWTVKKQITTRNEKIVTSLNGAQATVVRDSVAKFVYACLFEWVVAILNESLAGENGEAANRAEMFIGVLDIYGFEHFKKNSFEQFSINYANEKLQQEFNQHVFKLEQEEYIREKINWTFIDFSDNQPCIDVIEGKLGVMALLDEESRLPSGTDQSFLQKLNNQLVKPENAKVFKKPRFGNSAFTIAHYALDVTYEVEGFLEKNRDTVPDEHMALLQATKNAFLKEVLDAAFAATKPADATPPSPTVSDSANTTNKRASLIPDPGRTSLMSSATAGSGPKRPGGMVKKPTQASIFKASLVNLMDTLNVTNVHYIRCIKPNEQKRAWEFTPQQVLGQLRACGVLETIRISCAGYPSRWTYEEFAERYYMLVHSSEWEPMIKNLELKPLCARILEKTINDPDKYQPGLTKIFFRAGMLAALESLRSNRLNALVTIVQKNMRRKMAVKHYRALREATIKIQTWWRGLMARQLVEKVRKDAAATRLQRGIRRYLQRKRFLTIRTSVVAFQSRARGLLARRNFKDSKRTFAVVTLQSLFRGLLCRRAYKKDVRSVILIQSCMRRRLARKELKALKAEARSVSKFKEISYRLENKVVELTQTLQKRTEEKKELQNKVTALEAQLSQAVARHEESDARARQIQTDLTNAQSELSRSQQLLRAKEDVERKLEDAIVKAAEKEAAIQKLTEELAQQASQLESQQKLIDSQPVRNADDSSVIQTLKTEVSSLREQLNRATALNALTRGVRAEPTSPTFAPVLRLAEPGSGNANGSSLASVPRHQRRHSSAGVYAIQPSDHRTSQDELMFNAKRSQASNPRAVSVAYNGEDGLPQFRVLDRSSLYDDPAEEKIRLMQDIKRLDEDVLDGLIRGLKIPAPSLTSPAAVKEILFPANLISLITNEMWKYGLIPESERFLANVMQTIQSHVMSFTGEDAIIPGIFWLSNVHEMLSFICVAESDMLQGIGPGEENAVRPFEWADYERLVSVVKHDLDSLEYNIYHTWMLETKKRLSKMVIPALIESQSLPGFTTTDGGGRLFNRLLSSNTQPAYSMDDILNLLNKVWRSLKSYYMEESVVQQVITELLKLIGVTSFNDLLMRRNFSSWKRAMQIQYNITRIEEWCKSHDMPEGTLQLEHLMQATKLLQLKKSTPADLDIIYDVCWMLTPTQIQRMCTNYYVADYEQQTPISPEILRVVASRVSPNDRNDHLLLAPETEEVGPYELPLPREVSGLETYVPAYLNVPHLRRLAALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6W5</accession>
    <name>A0A4V2K6W5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_791141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145204">
        <property type="protein sequence ID" value="TBU53793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6W5"/>
    <dbReference type="STRING" id="114155.A0A4V2K6W5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="218" mass="24217" checksum="3D4F728A389E1FEA" modified="2019-07-31" version="1" fragment="single">KSFVESVTKLRPKLEAEGFLRHPNAALLRALLAVLNARSARTSFKLVKGRKGDTAMESALRLAAEAARRVAPDAVNVGVDPVWKISGASLAAMSQGFAYRAIKSAHAAKLKPRAQTNINLMNIIDDIESVFGVKVSTADVWRSIRSKHITKVCSQFLWKAIHDIFMIGKHWIREGMPEEYQSRAICETCGNLESMDHILFRCEATGQAEVWGELKKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K706</accession>
    <name>A0A4V2K706_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1041896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K706"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="67233" checksum="667FEF75B18BE861" modified="2019-07-31" version="1">MAQIAPFAFEADEKVCKLYVEQLQDVVNGGDYMPMETTFSEEDDPNIFDHVYSSLIPYQHYLDFFDDGPKPQVYWIWVTSTCRYWRDLICGTPKLWCDIHVYRRPDWLKLCLPRAATQPSAGLVKLHFHCPDFPLFELNILFHRQYATSLQTITFGAHPVWTTFFRKLLSTTLPNLTTLDAYPHLTSFSAFLDINTTPDLALSADNAPRLDVLRLSLLGPPTSVDLFSRLRILELSEASWRIPFNTLLDILAACSSLERLRLDRVLADVTDIPRPGEGLRRPVITLPRLHTLVVTSPHTFRTYTQVLSHLGLPAVTVLRIASIFEGVVENGLSLLPETFSALLPPSSASRIRSLATIDTVEYIAYRDIYSLFGRTRFSSRNILQLSFDRSEANEHIPRDEPGWQGATKTGLRDLVRLVPANNLSNIQLHVDFTALDRGDLEVAIRTFPRLASLSLTGTGDVGRVWKILTPTDEEAEMLCPGLAAVTISDGVDGDGFYASEEFFDVLLRSLEARMARGARLRLLQLCLHHWTEDEYDTLQGKYLARLKKLVVGRVEYEHVESSDEDSGDGESNERMGESDDEDDEEDEDEVDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K736</accession>
    <name>A0A4V2K736_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nuclease Le1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_935540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K736"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
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        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU54588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="321" mass="34419" checksum="5651DAE8B4B1936E" modified="2019-07-31" version="1">MAPLAAFTTIFSAALSAHAWGNLGHETIGFVAEQFLAPKAATFVHSTLNATWNFSLGPAAIWADQVKGEQAFKWSADLHFVDAQDSPLTGQCSVEEERDCADQICILAAIANYTARVVNPSLAAEQTLEALLFIDHFVGDIGQPLHVEALEEGGNGISAVCSGESSDNLHAAWDTGMVTKHIDQVHGGTPQQYANDLVAEIKNGSFASLAASWLACSSTTEPLNSRSLETRPGAQLERDLTEFLRSQEGEGITPLECPIGWARESNAFDCTVVFNFTTGEDLCSGVYFNDAVPVIDLQLAKQGFRLAAWLNVLFDGATNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8R8</accession>
    <name>A0A4V2K8R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_921965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8R8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9462" checksum="CE527205CC371438" modified="2019-07-31" version="1">MAPTPDAIGESWPPHAPDSGPCHRVQLKKAHARLLSKALECLSRPPLPLHECCAMLAMCWRHCVVFSVIAHPGLLGTNNACQDEAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9A2</accession>
    <name>A0A4V2K9A2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_974048</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9A2"/>
    <dbReference type="STRING" id="114155.A0A4V2K9A2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12372">
        <property type="entry name" value="RRM_CFIm68_CFIm59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="116"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="383" mass="39661" checksum="4EB09A9EEB68B71B" modified="2019-07-31" version="1">MPPADDDFDIYGEDDGFNNVKVDDENQEDFQIESEEKPSSEAATHSPVVGEKRLREEDEPEHRRDGPNDGGAPGYKSESSPAPGQNGNNAHSGQTNSSNANASGSGVGGAGSGQHDALYIGDLQWWTTDEDLRQVAHSLGVNIDHKDITFSEHKVNGKSKGVAYVECHNPENATILKNWFDNNDFQNRRASANYTTSVNGNPFRTLPKEPPPREQRQPYNNVQGGNMGRGGGNFRGGMAGNAGGINNMMNQPIRGGMVGGGMRGGMPNMMNNFGMGGFGMGGFVGNAMAGGAGFGGGRGGMIPQGPRGGGLMGGGGNFGGGRGGGMMGGMGMGGMMPMAGRGGFAGVQGHFNPAFMQSGGGGGGGGQFGQDGPRKRFKMEESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9G6</accession>
    <name>A0A4V2K9G6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7721 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_915889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9G6"/>
    <dbReference type="STRING" id="114155.A0A4V2K9G6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056138">
        <property type="entry name" value="DUF7721"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477:SF1">
        <property type="entry name" value="BETA-FLANKING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39477">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24845">
        <property type="entry name" value="DUF7721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7721" evidence="2">
        <location>
            <begin position="49"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="21155" checksum="DE0D92766F58CA1E" modified="2019-07-31" version="1">MDSFMNLAKQGLQAYERSQSDVSKTGGQEYNSPHHSQGGYSGEGGPEIDENEVVNKASTEHEQSIFSNALGFVKQNKGEHVRPVDEEGVQNAYKTAYHGNPEEAKALPASSLGSAAALKVLQQFTSGGSSGGKSQTDLISVAMAEASSLFDQHGGASQGNKQDAVNGAAMTVMKLLVQSKFGGGIIGGGNSGGLGSLMGLASKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9S3</accession>
    <name>A0A4V2K9S3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_954461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9S3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046670">
        <property type="entry name" value="DUF6540"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20174">
        <property type="entry name" value="DUF6540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="20380" checksum="1A76DCF4B8981CD4" modified="2019-07-31" version="1">MTQISSAVPPRTLTSPLTSPHCQPFMMSDHNSQIVLYVTQWWRGKDSEGKILPLHWALTFNTSGSDERPRGNVYNAAGNIDTLRYEAERGVPIRHDLWRGSLAVGRIPVESLDQFEKILSQNPVIRHDPEWNCQNWAWTALRELRHQGFAIEYNLTLHKLRMDMFELLEAWENGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVR1</accession>
    <name>A0A4V6MVR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_822504</name>
        <name evidence="3" type="ORF">BD311DRAFT_782825</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143592">
        <property type="protein sequence ID" value="TBU21603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVR1"/>
    <dbReference type="OMA" id="EHIFRYQ"/>
    <dbReference type="OrthoDB" id="5584477at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="87"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="713"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="768" mass="86968" checksum="DDD11524D5BBACB5" modified="2019-07-31" version="1">MSEREISERLIEAARDCRICHSCFLAPAERRLGFRDEPTGQNRTMGLFREPQEGSQLFADQLVSVEIHHAGIDPFNAGDGERCDAQTKRARSRLYDHISTIAEDLFVVQQRVFLFMILITGRKYRIIRWDRAGTVVTPSVDYYEQPAAFCEIISRFSQLSDTALGFDASATRIFPHDIDSLRMDVAALADTSDIDHSERELKDGDPGNSFTFAYVRSLFRASLSSDWPRFKLCVPDGDQAREYLVGKPTFCDTELFGRGTRGYVALDRKTNRFVWLKDAWRASHRIAEREGDVLARLNDARVKNVPTLLCHGDIDDQVTITADWWERKYALSPALSPSPSSSLSPPSPTLIGSQTSSSKKRKRVDESPPVSEHGEVIPKRTAHTDGPLRQHRHYRIAVVEVCMPLKNFQYGQQLVTVVLDCMKAHHQAATRQKTRILHRDISTGNILIYPRVVRLEGRANPWMMWTGMLTDWELSKPIDAQEASSRATQMGRMGTYQFMSVNLLKHLTKPVEISDELESFFHVLLHHSVRYLRSNCESTSGFIQNYFERYSSSGEFTCGQKSITLEHTGVLRNQQPYGPLVFFSPMDDILATMLKCFHAHYKVLNYEARKAAPPSPPPTLPTSGAPDNDSEEDDDDLVPPFPLVSIGYPHGDITIYGDTPLDDVPTTKEFQRAKRITRHKFLLEYLAKMRLDSRWWIGDRIPSPSATSADELPVSTSPSRTVPTSTSTSNKRRRLASPGCVVSIPARLHETTRRARATPRTLPARRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWM3</accession>
    <name>A0A4V6MWM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_939364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145236">
        <property type="protein sequence ID" value="TBU52803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWM3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8636" checksum="809A4CE48E7F43A1" modified="2019-07-31" version="1">MTRQAMSPSDLSSYEDIALPKSPELPNSVQLTPYHNSRVRRISWISFAPVPTFAMAYVVHRYYRYCRPLRFDPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWN7</accession>
    <name>A0A4V6MWN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWN7"/>
    <dbReference type="STRING" id="114155.A0A4V6MWN7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29797" checksum="6B3A4CE5501274C2" modified="2019-07-31" version="1">MDAALNEVGATTGGRAAHGAGQEAEARVGAARADVQRGREYRVMERMQHPALCTLTAAVALLLLRSPCILFLTSHSPCPPILSILSPQSPSLNDPNKTVITSCSYSIPLPSTASATLPSSSHNHVHLSLAAHPTLYHDHSAVAPHSFYPLYRFPDRLRHSFEHFSRRIAIAEPPIGLVATTCAAFIPRLEHLAVKASVTPLFFRLREHHCVSPAVPLLHTEVRDNDPLDEGAVNTYFPRGFPYAYLGLPSSFALRLRQRGTTQEYVYKMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWW8</accession>
    <name>A0A4V6MWW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Alternative oxidase</fullName>
            <ecNumber evidence="16">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_945969</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alternative oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="16"/>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWW8"/>
    <dbReference type="STRING" id="114155.A0A4V6MWW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU62298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="386" mass="43903" checksum="94099BAF521464E8" modified="2019-07-31" version="1">MHALPSPKVASRILPINARALPLRRALLTPCMASAINSRRSFASSFPRRDEKVLQVAKTNEKSIIGPGAEGPHIKDLSPKTPVVVPSSTEELRGDWVLFHPVYSPEELRSVEVLFRDAKTFSDRVAHTFVKIARWAFDFASGYKHKPLPANAATMSLEELRKGGYLMDESQWLRRILFLESIAAVPGMVAAALRHLRSLRLMRRDHGWIHTLLEEAENERMHLMTFMTLKNPSRLFRAMVLGAQGVFYNAFFLCYLISPSTCHRFVGHLEEEAVVTYTRCIQEIEAGRLPEWTNLPAPEIAKDYWRLGPDAKFLDVVYAVRSDESTHRFVNHSLASLKYESDINPFALQEPDMTTKGSRICFERDESARFAEEAHRKITDRRGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MGM9</accession>
    <name>A0A4Q9MGM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_941312</name>
        <name evidence="2" type="ORF">BD311DRAFT_762231</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143444">
        <property type="protein sequence ID" value="TBU26525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145277">
        <property type="protein sequence ID" value="TBU51903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MGM9"/>
    <dbReference type="OrthoDB" id="58529at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051719">
        <property type="entry name" value="CASTOR_mTORC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016540">
        <property type="entry name" value="UCP008459"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131:SF6">
        <property type="entry name" value="CASTOR ACT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31131">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008459">
        <property type="entry name" value="UCP008459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CASTOR ACT" evidence="1">
        <location>
            <begin position="63"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU26525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14634" checksum="F8FD90234B24EE12" modified="2019-07-31" version="1">MSVTREHPCLRLSVLPGVFYVRKVQEVPADVLRRIAEEPQSLLSITRTLEEISIVGQCTVEEESEGEWKCIKIAGPMPFELTGILSGLLEPLKQANIGIFAISTWNTDYCLVPKGRIEDAVVALTQDGWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MQY9</accession>
    <name>A0A4Q9MQY9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_930495</name>
        <name evidence="18" type="ORF">BD311DRAFT_691390</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
            <strain evidence="18">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="ML143407">
        <property type="protein sequence ID" value="TBU30250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9MQY9"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="730"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1233"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1257"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1297"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1349"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1379"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1417"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="307"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="455"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="548"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU30250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU56898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1472" mass="163407" checksum="FA9753D1FE6B5EE7" modified="2019-07-31" version="1">MSEPSSSNGAGHDYTEGASPLDIQQAVANASLSRQDSGYGDDGDAMFDGPGHAVNPSSVSRMTMRDDARRSSGRGSMSRRRSECSMSREGRTWSMSRSRRGSEDVRSEDRDGEDGDWSDHEALSGDEGDHEVFTRPRGRRRKSQSPVAARSSVFDNIASIFGGRHAPQTESPSRSRRPSISSRASRTSRTSRSRLLRRHSSRRSDLSSDYAVDDTSEDGDWDERWGYTSNEEESDEGETDIDRASLAPSGSEMEFGSYPPSPGPTLPLLAGDPVFGSEARIEMGELEPLPPPPAGPPSRQTVYVADEDVHIRIIGYEPISWKQWLWWLSCVCTFGVLALLGRWFPRLWLRWVTRERAFVDIKHGFVVVETAYRDIALFPVARIDYPYAISTAFSTRPDPSQYLPSYRAGASLPMLSTLMFVDYRYNRFALDPRTGLFSMIREWRDASWMNIAAVQNGLSKDVQVQRSTLFGPNLIDIEGKSTVSLLIDEVIHPFYIFQIASIILWSLDDYYYYAFCIALISAISIITTLVETKQTIARMREMSRFVCKVNVYRDSSWQECDSSDLVAGDIVNLLEPPLATLPADMFLLSGDAIVNESMLTGESVPVSKVPIKNDDLAKWRDTTDIVGDMAKSFLYSGTRVVRIRSGLTTDGRTGAPALGLVVRTGFYTTKGALVRSMLFPKPTGFKFYRDSMRFIGVLAGVAGLGFLASAVQFVRLGVRWHTIVLRALDLITVVVPPALPATLSIGTSFAIGRLRKLGIFCISPSRVNVAGQINVCCFDKTGTLTEDGLDILGVRAPERNTNRFGELLEDIHDLPTSRDKANFLHALSTCHSLKMVDGEIIGDPLDVKMFEFTKWTLEEGHVAGTAVVKNKSGGERPAALVQTVVRPPGSAQFRIEDALKGAGRHAHFLELGVIRTFEFVSALRRMSVIVKRLKSTSMEVYVKGAPEVMAEICDKSTFPSDYDDLLSYYTKRGYRVIAMAGKSIEGLSWLKAQKLKREQAESGLQFLGLVIFENKLKPGTTPAIQTLRAAHFACRMITGDNALTAVSVARECGLINPAAQVFVPTFIRGNASSRLSELEWSSMEEPTWKLDDYSLKPLPAPATRLIENEELESQDYTLAVTGDVFRWVINHAPLETMQRMLVKTQIYARMSPDEKNEVVERLQSLGYIVLMCGDGANDCAALKAADVGLSLSEAEASVAAPFTSRTPDISCVIEVIKEGRAALVTSFSCFKYMALYSLIQFTTITLLYSFASSLGDFQFLYIDLFIIIPIAVTMGRTLPYSRIHPKRPTASLVSKKVLASLVGQIFITSAVQFWAFFWVRSQSWYIPPPPNDPNSDGDKLEATNYENSVLFLVSCFQYILVAAVFSIGPPFRKPMWTNAWFMVSLITLGCFNLLVLLDPPKPLMNLLELMNLPLAARATLLLAVVVNVVTSMAFESYGTQAVSRVFGLIFELRRRHRVREGNIYKAVEGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MW79</accession>
    <name>A0A4Q9MW79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_927099</name>
        <name evidence="8" type="ORF">BD311DRAFT_751967</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143397">
        <property type="protein sequence ID" value="TBU31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MW79"/>
    <dbReference type="STRING" id="114155.A0A4Q9MW79"/>
    <dbReference type="OMA" id="MAHPMGP"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000009">
        <property type="entry name" value="Fatty oxidation complex, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF5">
        <property type="entry name" value="3-HYDROXYBUTYRYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="7">
        <location>
            <begin position="10"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="204"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="4">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="303" mass="32435" checksum="F08F1AE36138E6DB" modified="2019-07-31" version="1">MSISHGIRRAGVIGAGQMGLGIAFVSAVHAKVPVLLHDRSSAQIKSGLSFFDKLLAKDVSKGKLTSEAAKEARDRVAVVDDLKGFKDADLVVEAVSENLAVKQGIFRTLSAELSPKTILATNTSSISITKIAASTIPEGKTAADPEGKESASRVVGLHFFNPVPVMKLVELIAAAQTSEETLNRARAYASACGKEVTYSKDVPGFVANGLLMPFINEAILMLEKGIATREDIDKTLKLGMNHPMGPLQLADFIGLDTCLAIQQTIHNGTGDSKYRPSVLLERMVDAQWYGKKSGKGFYDYPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N6A6</accession>
    <name>A0A4Q9N6A6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_935131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N6A6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="387" mass="43173" checksum="2F6FDBDB6E6E6D0E" modified="2019-07-31" version="1">MPAAEFWAPPPEPKTKLGRHRLLSPTAGVHVSPICLGAMSIGDKWAQGAGMGAMDKESSFKLLDAFYEAGGNFIDTANNYQDETSEMFIGEWMESRGIRDQMVIATKYSTNSKRGRSDIKQQTHYVGNSMKSLHISVEGSLKKLRTSYIDVLYVHWYDYVTSIEEIMNGLHALVLAGKVLYLGASDTPSWVVASANRYARMSNRTPFSVYQGAWSVLERDFERDIIPMCRAEGMALAPWNVLAAGRIRTDAQEEERRKSGEKGRMMLSADWERTEEEKRVAKVLEEVAAEVGAPTIQAVAIAYVMQKTPFVFPIIGGRKVEHLYQNIAALDVALTDEHIRKIEAAAPFNKGNMYNLFGDGSDYGFFFKSGGNFDMWPTAPALRPAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAY0</accession>
    <name>A0A4Q9NAY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1000812</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145275">
        <property type="protein sequence ID" value="TBU51946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAY0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NAY0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU51946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20282" checksum="7A591198DDD54D30" modified="2019-07-31" version="1" fragment="single">PVRPQGPEDIRPEIDRTVLRKILLDAIPPHLIKWHHALASVHPLGNGQHELTFANGFTAVSDFLIGADGVNSRVRPLLSPATPAYTGVNGVEISLAPETARLPQLQETFANIGKGTMMASQISRMLVSQVNGDGRICTYAFIRKTADWSVPSNPAEAKAMLGEYFAGWQQWMLNLIDYADVRTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCS2</accession>
    <name>A0A4Q9NCS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_914424</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCS2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NCS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="607" mass="66913" checksum="01DF4F90798023E5" modified="2019-07-31" version="1">MLKLRRWAMSASSHHDQEAVPLPPAGFDAQKSKAASTTDTVYPESLPGDAERPVGALPVPPVDRQGLHRELSARQVSMIAIAGTIGTGLFLGTGRSLAQGGPASILLCYGIVGFIVYITLLLLGEMATQYPVAGSFNAYATRFFSPSYGFALSWNYWFNDAVSVASDLTAAQLVLQYWTTWHTWVVSLIFWVFLVAVNSIHVRAYGELEYWLASLKVITVVIFIILGIVVNVGGNQAHEYIGAKYWHIPGAPFVGGFGGFARVFVTASFAYGGTESLGITAGETKNPSRNMPRVVKFVFWRILLFYILSILLMGLNVPYNYPNLSNKAVTTSPFTIVFQLAGSHVAGSFMNTVILTSVLSAGNHALFAGTRVLYGLSVTTPRQAPAFFAKTTSAGIPLYALLATSSISILCFGSSFIGSGELWGWLQNIVGVSNQIAWVSIGLASWKFRRAWVRQGRPLSEMKFRAGWTWPWGPYFVVIAVVVIIIVQGWSSVIPKFSAVDFVSFYIEIPVMLVMYLLWMLIWRPSPSSAPVSLPTGDQVASGPARKSLSRRVWDFLTYNDAVDVRTVDLKRDEHEEEAADLADDARRESKLKGRYRWLWKVYYAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9ND42</accession>
    <name>A0A4Q9ND42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_918429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9ND42"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043792327" evidence="7">
        <location>
            <begin position="26"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="265"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="190"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="393"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="449" mass="47930" checksum="56D73AF1F8577A66" modified="2019-07-31" version="1">MIVALAPLTSSAVCLLVWILPLTAALQNVTIDDTIGDPITGLIPAYAPSNKWALGQQCSTCNIHSGTTNGTIDLGQVFNGTWHDSTYSVGDPDHTVSVSFNGISVYVYNIIANDLPGTTTFTNLTFWIDNEVVGSFTHSPENTEAFFYSQAVYVNETLPNGLHSLVMHAGGASESLILFDRIVYTSQDDPSSTSSAASSSSPSQSSPTSQAQSSHSAGKSSTPVGAIVGGVVGGVGVIVLLGLLVFCLRRKRDAAHRPDADRVDPFIIDERSGQPPGRPSDRRFSRTPKLPDLRFGRMRLMPRGPGSTATTTTTDASSSSRSGDGFQGHRPRLPPISPSETARIQEQAEYLSRIQGLEAQVRALEMQQQLASTSDLSGSRTQQSKTDSSERGRRSRGSSPRARRGRSPHSSTAGLRSELASLRNEIAALRGELTQDQLVVLEAAPSYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDI4</accession>
    <name>A0A4Q9NDI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_934660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDI4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="24087" checksum="3301120E8FBC00E6" modified="2019-07-31" version="1">MHRGMMGNPAILLRAAVQRIRSSAQRRSTKEMRVALEYVSFTWTKNHMKGVYGCNPAPWTLRCDLDVQTTAPASFGIMDLVRNHRHTTDRPTSVKGSRCQPRQTPVSQLFEQYIALHHKTMSPHSYHHLLCISCYPAGQTPSRHNSPHTPSRRSIICGRIPPACPHGTIYQSASFGDMDTVTSTIFPAHQLSQAHHHLSYHYALSKAEHSARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHX9</accession>
    <name>A0A4Q9NHX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145297">
        <property type="protein sequence ID" value="TBU51644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHX9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="562" mass="62299" checksum="BD4ADE8C664A628C" modified="2019-07-31" version="1">MQLPAQYLVDSADSVAAVAKLPTELLRQIFLSVVSDCKTSTDITPFFYTITVDMLSPLKLTHICRRWREVATDMPELWTAVASCVGRRIVGNQTNDILSLFLARARGHPLSALIANDLHAANKLCPHMDHIRTLEIVGYPALYTLDILARPAPALEYLILACPPPPDAISFAPIIQAPIIFRENAPSLQALVLLNMSQLPTQSFPVLTDLHVGMQTRPRFERLLQLLEGTPALESLAVVSYNAGEIWNIPDLTIQLSRLRRLALIRMPMHLAMIFLLRLTIPASTTLYVLDISEGIGFPVEIPQTPPISAADMLEMVMCGSTLSFHLRASAQDLAPRVRFEARRDPFSWRWWKSSYQSLPCANLTELRVALEADNDTFLPPFLDAAVALSTLELRLYVPAVTERSGSGIAGARFDGAPQAWVGVCALLEQAMPVVCPRLAEVALIDAASSECAWDGFVAGSEEAPRVAYVPDVLCVVAARAAAGRALRRIAIQGRWRPVQRERVSRAFAMGAVVTDFEFRELDADAPALFEFEDHSVAEVWENGYWRHELPKHTLPWRDVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NI09</accession>
    <name>A0A4Q9NI09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_930774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NI09"/>
    <dbReference type="STRING" id="114155.A0A4Q9NI09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="627"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="730" mass="80433" checksum="8D61FEF5FB355A71" modified="2019-07-31" version="1">MSDGVTQPTQTATQTQLLSQHQYVEDTSDLWGFLIPCNASNPYISRINFHKTKLTYAVGRGPHNDIHFPKCPIVSNKHCVIQWDGVDDPSTSAVTVTDYSSNGTFINCARISEPGTPRKAILHDGSEIAFGAYVPQDPEKAHVDYRFIFRKTRPGAPADTLDESYDIQHVLGRGSFATVVKALHRTEGQWYAVKIVQKSRLRKGIIDEGQETREQRAVLREIDIMKRLHHEYICRYKDVFIEENSMSLVMEYVEGGDLLGWLQDHDPDRPPSEKEVQYFTYQICEALHYVHELDIAHRDLKLENILLTKDDPPVIKIADFGLAKMIDSVTFLHTMCGTPEYLAPEVVTNSAYDKVVDSWSVGVIVFSLLTMRTPFIEVEGATDVVTQVTNRQIEWSLLQTRKVTEHGQEFIRELLKYNPEERMTLTDARNHAWLADQKAAYEATQDQPVVSQPSQDTSVEFPPETQEDSQALSTPFDVSMRSLTPGRVVPDGTSIVMNAESQTESIEEARAASEASSRAATPAHVLAEDAYDLRALPSSQLEDAGAGAAGEDFGSRPHPVQRRADIIRRAHHRGIRLPAPSQDMQARAAAELDTVAGDPAHDAAEPEGVENVGSSRMLVPASAAVVARPSKRKAVELDSDPASAPLGDSNGGDDEGEGALGRSTSGTGSGAKKTRRGTRAAKRSPSTKKARTGRSLPTPSDDQEVSEPTIGRRRSSRLASPTKLKSAHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLF2</accession>
    <name>A0A4Q9NLF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_946609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLF2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NLF2"/>
    <dbReference type="OMA" id="PRNFMSM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="395" mass="42537" checksum="CD2307C203BD4EAB" modified="2019-07-31" version="1">MFAQYSPLFTSGLLSESNTPSTSRRPSVEICSKDVRESLPVDATVESLYETPTSEEDGIFLTLAPRRRREAGNSFLSLDLAENHSLRSMSLRRKDTFTSRATTHFGRSVPTSPTTAPVPMSPPIQFASFSQLGPRKSLVRHSSREGLPGAKPVPSSQPPAAPLRKRPTDLSITLSTCLSPLMSSGSSSLHRSAYSEPAVLSPISPLLSPIERSYFAFSPPTSPSAMQTSFTSAEAPHSAPAAVPLQPRPSMRSTVSFRTRQVNRSAALAALEGRAERKARRGSRPSNFMSMSDDEDDVDLDDSEGPSSASMSSPASAPATASVQPALLEVLHEEEDVVVPSSMPVAQKRIPSTPSSKSRSRRGTLESLLSPLANFIDFGDNEGSTRSWRSFVEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMQ0</accession>
    <name>A0A4Q9NMQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_951760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145201">
        <property type="protein sequence ID" value="TBU53945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="6978" checksum="709B87248F653CD4" modified="2019-07-31" version="1">MIVSRSTSILSMHANAISCGGVDGEYQSPSALAQLYTGHAFPCLADHVHNGPPSPHPKGGVWHPLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNC8</accession>
    <name>A0A4Q9NNC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_813621</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9NNC8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032467">
        <property type="term" value="P:positive regulation of cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026708">
        <property type="entry name" value="CSPP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21616:SF2">
        <property type="entry name" value="CENTROSOME AND SPINDLE POLE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21616">
        <property type="entry name" value="CENTROSOME SPINDLE POLE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00243">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1032"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1434"/>
            <end position="1660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1774"/>
            <end position="1863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1438"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1478"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1507"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1575"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1595"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1612"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1775"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1792"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1831"/>
            <end position="1845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1863" mass="207659" checksum="02886A0688D98410" modified="2019-07-31" version="1">MSEAPEASVPSGSPPDAPTAIASLSNPAGATVRDILAVADEVLSLERKHAPENNEADEALEWHEVIELQAFIERKAWIEAKIKFLEQLPPIEVFVGLDAVRTSATEVPGLPTREQLQEWLVEHDKIEKETEIFDSGELRKLKKFTKAAAQRNLSPADTDLIEITLTTIYSFDKLLHLLRDRLDNLNLLGVRITWEERRIGAWQELRKLLEDMRDFLGTRARWSPAVYENLETDDAVPEERTPMKRRGSMVSMTSEASHASMPGYSRGARYKLAESLSQEAAQLASRTSSLRHTKIAAAGKALDKLIDDSRRPVPDELLDEQDKLENEGIAEMEDIGKFVMQMVMQWKKADEFYVDTLKDKSDAQTLLEEIEVAKLSHPTARQDASFMSRASALSKRLLLRGNPSYSPMFPKPEHHHFPEQTRCTDAVVKELSSEAASALQQVKKAEACAKEYHAFLEAVKQVETVCKAASDLSSKFLSLVDRMENGISTTSGDGTPPDLSTVACLDSTHHSVFLSLFPSILQELQQANIECGPLLSRARAALLQLDFPGVDVQFKSDSAAAIDALEASRAAATKAKDLVSTHIFTLTEVRKVWSAMDHLFHETDNARSEIVDAMSRQMWRQQVRHDAPPTPESPAMSLPAVSTSPTQVTERLTQLRTRLTQEVSMPLSTLNPSLSLALREYLTRSSSALETLLNTTNDTAQFWEAVQKQAAMMGSVRDEVQSFQMRTEDLKVRYDKAAQDTFAGTLDEDAISQTEQSLAAELASTKSAIQLFLDELPRRIPFVHEDKLVGLSKRTSTKRRAAIPGAFSLDTIQQAAQPSLPFDPAALDKGVRTDSNTYSMMLSGAMKTLESKAAYFQLAKRAHVVDVVLVPLVDHLARANDLVTTVHATLTQGEERISSDHLSELASNLEDASKTQESSVEQALSPVREALQVLRSTPGLSDSSAKDAVVSTRQRAVENAESQFISWKKSIASLKQQLSDAHKAELHRVAEETRLREEQERLEAEAEALRAREAAAAVEAERLVALEQARVEREKADAEERERRERERAELEERERQERIAREKAEAEERERRAREEEEARARRLQAEAEERARREQAEMEERARRAKTEAEERARREAEEELRLERERVERERMEKERQDQERLAKERAEKERHQQQLERERAEAEERARLERKRAEAEERELRERQEAAEHAALEELERRRLETLRLAEESAVTDSPLETVEELSFSADDIFSVRTTTSGLSSEMSELSSRIFSFRKRLRSIGINDAARPSSRSSAELPTDDARKTMVQAFSILANEVLQLPRSVPDEPVVNADLRSLRSEMEASKELLTRVHHLADFSLLLNDCDEALSDLLEHIDSYPAPPVGPLAAIHRSNTSLTPEDQLSARLTFTRDVLSRMKTLARTLSDDRRVPAEHERVLQTWSELEAMALDRINGQKSRPSSVISSGRSSRASVMKSSSHSSKPTDSPRIRASLDVPRPRHSLDKKGSFSKLSASPKFLVPPSPNPNARRAASGSSVSTSAQTRSSSRMSVASSIRSVSGPMSGSGSSGSLYGSTFSSRQRTNSTTSNSSLFTPPMPRRPPPSTGSISRPRAQTGGTRASSPAYSDAGRSTGRSSLNLPRPSTSTSHSTWGRAPRLSFPTPHQSPPSRIPTAKPRKPYVANPKNKLDVAIGDVVNKLPVDIKIELVADTWKDQSGKYWIGDTEPKLCFCRILRSQTVMVRVGGGWQELSRFIKDHFADAFRLLQDTSPPRLASREEKWINSSTLAQAAEAISPMVPPKTPEPQGPYLPSFALSTPSGKSPQSLKTTPSPGSPLHALQFIRRAEMGDLSYRPETPTRSTRSGTSSVLHTPARHHPHSQPAWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNJ8</accession>
    <name>A0A4Q9NNJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1042609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asteroid family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145223">
        <property type="protein sequence ID" value="TBU53154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNJ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNJ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026832">
        <property type="entry name" value="Asteroid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665">
        <property type="entry name" value="ASTEROID PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15665:SF1">
        <property type="entry name" value="PROTEIN ASTEROID HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="891"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="931" mass="101042" checksum="44CF3EAA0D52A67B" modified="2019-07-31" version="1">MGVHGLTTYLRENKHILSRTVQLFQTNDPQRIPVVVDAWSFIYEIVYCADLPWIFGGEYPELARLVEHVVRAWVDIGLELHFVFDGPYPALKFPTLISRVTQTNIQSGLLFFRTSATARSSPRFLHETAMLPPLAYSVCVDTLLSLTSQAQSESPSARRLYLHFADEEGDPYAVALAARLDAYVAGRDSDFIVLNAEGYRGYIPLDEMVWTLTTASADGTSWDVEGSVYSSNVSVAGDSEAPSIGEDEDGFRTVRKGKGKKKRQVEASQAQRAGRGILPPDALGALGLSPDLPSAAQGQLALSFTVYSPTTLATHLDIPVSLLPLLGALLGNDFTGAPASDDLAPAPATTADIRSKGRGNLQRLFFERQLTLAQRISRVSTTLSSLLAAAFDGSGGGKRRGKRAIGSVMELIDAAVTALLIRPLDTFATGEKEAIVERIVEATLQYAVPRVEVEDGMEQGQEEFGGIRWASGVCPLHLQDVCPLFAVLSGLARERDAAIALHEEGRKSEQAEPDNPVGVVRERYVGAFRRGLLDPHLLDVAQTGTMWPRMFLEDPDKETVLRSVGRPIRLWTYAILNAGIGLPMSPEPDPAEREDEDEESDEDELIDVVEEDDSDAEPIPNALARLRGALQQLDGSKEGADEDSAAKATPPSAGSTSNGGSSHAKLPKLVTEYVRRGTRLVPEEVTVPSLSDMLREVVLDAPMDSRTGVVLPPQIWTYELRRALLLRGLASDLPAVAHLPDDRLVGVVALRWAVRTMHQRSLDSPGVKERFLERWTQVEARAVLASLYSPESDPAPNQLADQVAEERKDHIVPTERHIQLVAQISAALDAIEQLSQVLLLSSKITTPARQFSGMRCHALLSGRVSVVVGDELWQACVGGLEDAYALPPQRRTKKAAKGVPTPPAVTTSSAKRSGNSSKTQGLFALLADAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW50</accession>
    <name>A0A4Q9NW50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_945264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW50"/>
    <dbReference type="STRING" id="114155.A0A4Q9NW50"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="2">
        <location>
            <begin position="263"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="446" mass="49308" checksum="10033823AB43EA0D" modified="2019-07-31" version="1">MTAYVDALPSDEESCYYAAHLEFRANPHSDAPVSDDALAAVLPHCPHITSAVLGGIRDLSSRTLILLASHADELAHLDIAGCAYVTDLGLKAVATHATALRAINLGRTFSTTDAALAALVRGLPLLEELAMDMLPLVTARATRDVWTYAKRLRRWSLSGCKNVTDSGFPWVPARDALEVAREESSGGRGRHRSWMESLPPLVLPPLYKLHDLRFLDLSHCARLTDAAVLGLVAHAPRISRLNVAGCVELTDRAMHEICKLRDHLSEIDVAGLGRVTDAGVFAIASTCTRLRSVDISFMPRLTDLAIQELATLPRLRRLAAAGLPRVTDQAAFFLAEHARGLAQLHLSFCTRLTLEGVRALLRRLAELEHLSLSGVPALRRRGVSRFSEGHHQHEGHDARKQIHWVFRGEHIRALGAFLEKEEWRKREAERLNILFEPRGDDSRALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3E3</accession>
    <name>A0A4Q9P3E3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosome biogenesis protein Sqt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_928043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3E3"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3E3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="422" mass="44877" checksum="ABAE2CDC85CFFDCB" modified="2019-07-31" version="1">MSAERAEDHHFQEREDDPEGEDFIDPNDVLIELAEDGDHPMDDDEDGQGPGPEDEIVWEDNSIQHFPNHKGSVFAVSTHPTAPLVASGGEDDLGYIWDIVTGDELVKLTGHTDSVTSTAFSSDGELIATGGMDGKVRIWRRVGKEDWNKWEFLTELTGPDEVMWLRWHPKGTVLLAGSNDTTVWLWQLPSGNTMQVFAGHMGPVTCGDFTPDGKRIITADAEGTLIFWDPRSPVPVFKLTPEDQRFALDGITSLAVNPASTLAVVGGTSGGVRVVSLSKGEVVSALAGHQEGESVEAVEFVELAPPVPLSGTAAPAAGGVVVTGATDGKACIWDLGTMRLRATLEHEDAVTSLHRLTTPGKGHLIVSASTDKVLRTWDARTGTLVREHKGHSGGVLAAALGMAGAVVVSAGDEGVCLVFPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8T4</accession>
    <name>A0A4Q9P8T4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1043708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145460">
        <property type="protein sequence ID" value="TBU50999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8T4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU50999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8486" checksum="47F8C12FDD8C86BE" modified="2019-07-31" version="1">MNTSLLEDTENVTDLYRYLGYLAKYLKYPKYLKYPKSNGLGQVGWVDLAKYQVLGQVLQVPVQVHAQVHCEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAS7</accession>
    <name>A0A4Q9PAS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_953074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145284">
        <property type="protein sequence ID" value="TBU51800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAS7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAS7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="280" mass="31507" checksum="963A17D5764E78C5" modified="2019-07-31" version="1">MLDTTCSKGSFDLQYTCLRTTSRSEKAAMLQSHPHDLQTAHTRHKTLDRLHRFLCDEIYAPAATGVRPPRVRLLVKFFERGHLREARAKLLPIDSPQPIVPCPKLGYAEVMGGFREQADVYAILRGSRGEFIWMRSEKAAMVRGLNTRAPAPPSTLLLASCLSEYAHTLDSLPTAKIYEEALRLKLGGEGKIRIVCHVVDGLCSDRAHMRTLLDRILDKNFSKTAEQLGRKTLYLHVTSKHCGRLPIDGTYPNLEKKDDNVDLITTPRKKERLEGAPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCV0</accession>
    <name>A0A4Q9PCV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Legume-like lectin family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_941386</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145280">
        <property type="protein sequence ID" value="TBU51865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCV0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000095">
        <property type="entry name" value="Lectin family integral membrane protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF45">
        <property type="entry name" value="RE50040P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU51865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="344" mass="38093" checksum="123D0F858735F72B" modified="2019-07-31" version="1">MFFKGLLYCLTLLPLGILAALDDKSKLANRTIDRTVSLRTHSIYPPYIDQDLQNRWWDFGGDAYVNTNKHIRLTRAKPSQMGWLWSRVPLTASNFVLELEFKVAGDNNHLFGDGMAIWLAKDRAQPGPVFGSKDNFEGLGIFLDTYANSRHPYSFPRITAMLGDGKTAYDSEHDGEKNSLGACSANFRRTNVATKLKITYIREQYLNVKIQYKAWDEWTECFTSYGTVLPLAPYVGFSALTGDVSDNHDIISVTTYSAILSSPDAQRDKLTGSKKPGLAGVAASSWSWTFIKLFLFVGVVAGALYGYKTYALRQARGGVAGVGVGAFGSVGRSMQGFGYDSKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD83</accession>
    <name>A0A4Q9PD83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_831452</name>
        <name evidence="1" type="ORF">BD311DRAFT_669068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143457">
        <property type="protein sequence ID" value="TBU25657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145236">
        <property type="protein sequence ID" value="TBU52804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD83"/>
    <dbReference type="OrthoDB" id="2752228at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU25657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="231" mass="26634" checksum="DF1EF3B740B0BB15" modified="2019-07-31" version="1">MGTLHQGIVLGDIIDDKRLHILERAGDRAAATFNNPEGIQIFRSLSVEPEIAQIMKRVRDGDYSSLGLFGKFAWWDYRMWSNQDTFNKWALLLLLRLDEKQSISALPREDLEICATHLANYSSRRASFHLISAERLSMALEWGMGLSIPLAMLARWSGRRALYLPMNGWQRLLLGAWMYVELPAGFREFGYLRRIREKDVAARLMIDVFGDFDEEFKEMGIEYESSPPDPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEC8</accession>
    <name>A0A4Q9PEC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1007140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145340">
        <property type="protein sequence ID" value="TBU51321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEC8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19184" checksum="DB1A54E60147A0D9" modified="2019-07-31" version="1">MIDTKLDDDDWYPRASESEPAKSLQYLPLHPRFALYFATFTTVSRLYIVNLTFGHFSDFARMINSLPVLRKLVCSNVRCVALGPLPFNMRPRADGSHAPAPPFAPNLQVLCLVCTLQYAWHASQIIHPVERGHTLRPETGIGMWAASQGIASCHALLPRHKNGPARYVDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFQ8</accession>
    <name>A0A4Q9PFQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1001106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145281">
        <property type="protein sequence ID" value="TBU51852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFQ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="295"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="787"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="817" mass="92763" checksum="E4A0500DAAE52503" modified="2019-07-31" version="1">MAHAAVLAEKEEFSDAFFPPPTTSTTPSLPKPRIKSNPFASLADADNMKEAEVRAKFTRAINKHNLIPGFKVAECGERPDAWEPEDAEYKLKVDAAVYLAKDAPTDSRPHWADQIIPIEFKRDSVALDPFDDSKENINTSTDTRRKVRGQIISYAEFIFAVQQRVALFMFVVIGKQIRFVRWDRSGAVVTRSLNYVENWRFLCEILWRISNSSVSDLGLDPTATRLYPDDADYQRMDADALPNDSDADDTERDLMPEELADDSKYVFKYVREMFAKSVHATWPRYRVEVPYGPSMRTFLIAKPSFRVKGLAGRGTRGYVAVDCESGEFVWLKDTWRARYILIDPEGDILQKLNDAKIANVPTLVCHGDIAKQATLTPDWWEAKNPPMSDHVSSTEGDPLQAPSASASTSRRTHAQSSSSLKRKRGDERSGNGASGPRTGWRDDCPLRHHQHYRVVEKEVARSLVDFMNGRQLLCVVSDCVYAHSKAATNPKTKLLHRDISGGNILILPKVSKEEDGTRALKWTGILVDWEMSKPLQNTASRPRQPERTGTWQFLSVALLSRPKIVEICDELESFLYVIIYYAVRYLRSNLEGHAVGNWIDTFFDTYGVTRDAYTCGDKKIATIKEGVLVLANDENLKFNSPMDELLSNLLMWFRAHYIVTKHKRRQDQEKALRYTAALPPDGVPLGKARKPRRDGSEMTNREDRSKHELVDFSKPTEMEYKYAVYVLEHTRMMNLLDDIAYEREWLSGDRTPDRIPSDWAAPVRPEGPTVPASFASNLHKKPKISREDGMVTMPPFPFAHANSAIPKTPEKKRVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFU7</accession>
    <name>A0A4Q9PFU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_980773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFU7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="188" mass="21012" checksum="0F7937E1979BA755" modified="2019-07-31" version="1">MLEERPFALLDHWRSLPIRACLHLETLVVTFCNVPADDSELRTQGYRKASLEANLELVNSAPPSLTLLLVQFGNGDTDEMSHVRSWDLPDFALYWSSLDNAIMRLPVLQVVAFAFSPPQVVEWATSHERTIFINSNNSNPPLELGPEEDAACKAFLESALPQTYAKGLIKLVLKDETIGSFAADRTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFX2</accession>
    <name>A0A4Q9PFX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145356">
        <property type="protein sequence ID" value="TBU51236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFX2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18352" checksum="80CD901B2D7256DA" modified="2019-07-31" version="1">MLHSCRLVSKRTSPPPVRFSLLLASPRHLLVRPRPWPSAERSRQKRCSVYLAGRLLPASRSLTTCGPMTLCAVDPQRYETRGRHLLLTAMAANSTAALCFRYLIDSSPLREALDELLIARGCCLVQSRISAQPASLRARISSTAGHHLNLQCYGSDTEHSVSGHHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG19</accession>
    <name>A0A4Q9PG19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145265">
        <property type="protein sequence ID" value="TBU52117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG19"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="20933" checksum="D8EA1E06A45E630B" modified="2019-07-31" version="1">MYCLRRLGSPYSGVNKRHWRSRVRIKIEGSADSLIRRRERYQRVALNSESLEERSTGRRLRLWLLGAAVLSCLSNGSECCRIENQKTSMARSRSSVTRMCGGVFIRRWLTLLGTDFACSERDEGKYEKEVTETDQTFRAIVACIFHRTLLREKSTPPYATGVARVRWLPWFSAVAPLSTHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGA4</accession>
    <name>A0A4Q9PGA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_249695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145262">
        <property type="protein sequence ID" value="TBU52192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6667" checksum="7A5CCB55D919EDDC" modified="2019-07-31" version="1">MCSPKSHCSWPLGQGLLTASSCPAFPLLTHALGLLYCGSGGAKLAVYAHDVQMCEIISYKTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGD8</accession>
    <name>A0A4Q9PGD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1043503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145311">
        <property type="protein sequence ID" value="TBU51526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGD8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="413" mass="45821" checksum="817FFB84B839B0B8" modified="2019-07-31" version="1">MTPMMLDYNLDLNSSISGPSNASSISRLEGVHLLRNHLALVYAFEGLMASPILRPQLKALSLEYHNDDRRCEPFFILGPTQYPALEHLCLEGVPILLLDPTLWQSFPPLTHLVIVQSTSDSIHTQIHILMHICPNLRNVVLSNVSPHVNSPGVPTPLPESARVSRVILHDMSGVSLRFYLSLFPPHHHPRALQVIHDTLPVSGFNYEHLLRDRIQGRPTHLQVAVFPDSTTSSGGFKISVTVATARNAVRVRSNVNLLYKSHYGLPDVWLNSLLWDAGVDLSSVREAWLVNVAAPFTALVAPFNSSAVATLRQLPALETVVLVTIDHPSNGPGNAYWPDVSVLPDTAHADFLTVHHKTLRLVYYDACPPSVCPFSRENFKLGFWRMLEQLASGAYRYLGPRASHRAVVAAIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGZ6</accession>
    <name>A0A4Q9PGZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGZ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11956" checksum="9464C84900E13AE5" modified="2019-07-31" version="1">MLSQWQRLGPDQTNCSPSRHRRRQQTCIASFVPGLAAKSRPESILRDSTLATSAISMAMWMGSVLGTPQRRRDCKRGSASMQCRHKAVDELAGVTKVLNSASGRGLARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH54</accession>
    <name>A0A4Q9PH54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH54"/>
    <dbReference type="STRING" id="114155.A0A4Q9PH54"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="421" mass="44876" checksum="C1BC5491EF4885BE" modified="2019-07-31" version="1">MSGSILTGCFPRLFCALLWKRLEIKDIRPSGGASSPFSVALLSASYALGAFNLVKSYSGSTFFDGWQYDSVPGYDNTTNGHVFYLDGAHANASHLTYVNDAGRAIIKVDNETVVSYPNKRNSVRISTEDFFDIGSVFLFDATHVPYGCSVWPSFWTTGNHWPNTGEIDILESYNLEQANQMTLHTTEGCSQAPNVQQVGKTNDTDCGAGGSTIGCTVVETKANSFGEDFANNQGGVWAAWFDETGISVWFWSRKDVPASVSGATNTIDPTTFGTPSAAWPSGSSCDISKAFGKQQLVIDITLCGDKAGDPQIYQSTCGGPLRNATYDTCYQLDVIQQPTVTTPNQTALGNAWFEISYVKVFTSDTAEVANSSGATAPAAPTSTSANGTSSADGKNDALSVHHMYTPVVVATLLAVASCLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH77</accession>
    <name>A0A4Q9PH77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_941014</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145266">
        <property type="protein sequence ID" value="TBU52106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH77"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="290"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="665" mass="74285" checksum="0EFD18125231161E" modified="2019-07-31" version="1">MRLLDTETGRFVDRDPAHTTYAILSHTWDTSGGEQTHKQLRKILKRYVAEAGRPRSDSRGLHAPSPPGWMLNQPLGGLITPESDTAQPSAFPIDSSGSLYLPPSMAPLPSIWDDPELSPKIRDACAFARANGFRYIWIDSCCIDKTSSSELSEAINSMFVWYAEAQVCYAFLADVPVGEDHTAAGSSFRRSRWFTRGWTLQELIAPWDVVFLSCDWTVIGSKNTLSRLVEEITGIDREVLLHEKSLDSVSVAARLSWASKRTTTRAEDQAYSLLGIFDINMPTLYGEGERAFRRLQEEIMRRVPDQSRFAWGRCAVQLQGPPPLPSDDSIGNPRAAYVTSFIPRPSSLLSPSLTQFQDGGKIRVVPRDNILQRLKLSPGHPATEYIFSPYGIRMQIPVLPLFLFIAPGALEHIRTESRHWYLAILGCESVDYPGHLLGRVVRICAPGSDIQAAQAGVACVEAQDDSAQGGFDLVSLSPMTIERYRAHIEVKTLYISHPERTTGTERNVSHRAHERISLILPQKAHDGLRAQGYAVDLQGPDQSNPDRHRLTLSRQDDHTVTIAYQHTLEDDGSKLTIKADIRTTWFHPVVEEYFKDAISWTDTICWASHLQRVEVSQARPGVKTITVALGLDFAWTSRYFLSVDVRSDTTAVFRSSGVAGQQDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHM1</accession>
    <name>A0A4Q9PHM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_860424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHM1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU53337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="49700" checksum="5C1FE2374E098DE3" modified="2019-07-31" version="1">MDSKQEDLMNTSPIENGQTASEVEAVNDGHVNVEDEFRAPAALLNKLSILDRLLTPAILVCMVVGVLIGNYVPGVEAAFSIAQFQSVSAPIAIGLIVMMWPILTKVRYEALPALLPNRHALTHIILSLALNWIVAPFLMLALAWAALPDLPTYRTGVIMVGLARCIAMVMVWNALARGDSDYCAVLVVFNSMLQIVLYAPFALLFVNILGGGGGVEKTLHVSYGDVAISVLIYLGIPLAAGVVTRFAMLRLTSRRFFESTFLPYFSPLALLGLLYTIVVMFAYQGHHIVHNLGPVFRVIVPLVLYFVIMWSTTFAFVWWCARPRPRPAMVRGTSASMDEKEKKKRAEWSYEMAVVQSFTAASNNFELAIAVTIAVYGVGSDQALAATIGPLVEVPVLLALTWVALFLRRRLTWHSGWDVEAGTILARDVVEGREEAKRGDENLAIVSGIEETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ59</accession>
    <name>A0A4Q9PJ59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_936712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ59"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJ59"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="170"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU54106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="41408" checksum="57F867BFC794B39F" modified="2019-07-31" version="1">MSPSKLRLKRTPAEQAEHDLRKARKIARKAAKHRRQHDEDEYDESDGHSHRKKRRRTSVGLSSNDIDDSDSEYGPQPASSHRAHKPDYDRIQAEIEEQRFRDKLWGALGDDERLDSVEASLNSYAHVPRRWRGGGMERMDDESDVDPRYMEDEEYAEWIRAGMWRKKHAAEHEEQMRKQAEHNARKAKERAIREETKRLERVEEEARRNRRRAREQMRAGEARELYEIRWKALLAPSTSIESDEPMLGLPDVPWPIYLAYPAGKNQPPSALRIDDFTIEAISSFLLPHHEEDHNSEASKKGRRERLREAMLRFHPDKFEGRVMARVRSDEREIVREAVGVVARTLNTLMAQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJU6</accession>
    <name>A0A4Q9PJU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_77463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJU6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="570" mass="61561" checksum="2FAC5596AC0A6DEE" modified="2019-07-31" version="1">MNPRAIHALNATPDDGRRIDCTPAAVSWVSNQAISSPPLQGCSSRAPTPTPPQDDPQLHLISPPTSRSESLFASPPTRMALVARSIPTSSNLVRRASISQSSEGAIIGIVVGVTAFFLLLLAMVQYRELKAFFERIVMRIRRCGLDTPAKDRVWDVLSTQETGAMTSTAGSTADSFMTRESRMRDMSSYLVSTREALPPLQPNRRPPSMFDPALVVSPPQPPPPLPRLEPLRRKPSTTLAALTVPSRESSPPPPIPPKEPELENRIATTLPTLAAPKPVLGADLRPSSAYTSASTALSDMTLLKPSTRPRGEGEPENDARLSRVLTVANPDKGFLPPIPPVPPIPPIYIQPKQEPSPTLTTSPRPLPPKPSLPSSPLAHSPLSEARTRMDSLSPTTPSSTSYHAPSSLRRSNSTGSTRTPPMRKPVPPLIIPGRADFSSFDAASSVWGAGSRKNSLASTAWDDAPAVFSRYGSPVPSSSASQMYRARDSGLSEWTWTRPLEEWEKEQMNIRRKTSAGELTPPLGQRGARKEGSGDSWGRLGHKTSASMGEMRVARGIVPDVPPVPRQYLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK38</accession>
    <name>A0A4Q9PK38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_827928</name>
        <name evidence="2" type="ORF">BD311DRAFT_677093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143563">
        <property type="protein sequence ID" value="TBU21991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK38"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8237" checksum="541B30CB79588033" modified="2019-07-31" version="1">MGVGHRRLSSSQRRETLISPVRDPQRLHGSASLPHRFVCPFAVLTPSLYCPSPMVAREFARASSRDRVACCQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK51</accession>
    <name>A0A4Q9PK51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GPI ethanolamine phosphate transferase 1</fullName>
            <ecNumber evidence="2">2.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_72219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.-.-.-" evidence="2"/>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK51"/>
    <dbReference type="STRING" id="114155.A0A4Q9PK51"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16020">
        <property type="entry name" value="GPI_EPT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007070">
        <property type="entry name" value="GPI_EtnP_transferase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037671">
        <property type="entry name" value="PIGN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12250">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="431" mass="47917" checksum="4F8D8B05307C2ED4" modified="2019-07-31" version="1">MLSQSDVWKLQIVGLIFHHIFADTVFHCYFTTRVVHGMEQYSMPYADWAKRVVFIVGNGLRADLLFMKNGFVDIAGSPDIVAPYLRSIVETRGAWGISHTRVPSETRPGHVAFISGMNEDVSEVTKGWRQVGIDFDPVFNQSSTTFAIGSPTVLASFVPGAPPGKIQIWKFDPELEDYTKDATQRDKWVYQTLEAILRNSTAHEDLDRRLRADKTVLFLHLPGLDITGHSYRPFSKEYMMNIQTVDDIVEKTENLFRQFYGDDDTAFVSTADHGMTPIGNHGDGHPDSTCTALIVWGKGVRGSLPDSTPSSHDAYSKQLGLSHLLRRDVEQADIALLLSALIGTKWPTNAMGMLPDVDPTKPGYLLPNQGNRYMAQAALVNAQVTTGYSMSRRSTVEELGQTQLSAIETLIDVGDHYQARLHAMVLISAVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM43</accession>
    <name>A0A4Q9PM43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_826205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM43"/>
    <dbReference type="STRING" id="114155.A0A4Q9PM43"/>
    <dbReference type="OMA" id="LGGCQGT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="45"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="454" mass="49856" checksum="722085774D82663C" modified="2019-07-31" version="1">MSIYTQLLEQNIYHVPSFTLESGSVLKDVPVAYKTWGQLNETKDNVMIICHAFTGSADVDDWWGPLMGHGKAFDASRFFIFCGNVLGSPYGSASPVTLNPETGKPYGPEFPLTTIRDDVRIHKLVLDHLGVSSVAVVIGGSMGGMAVLEWPLCSPPGYVKRIIPIATSARHSAWCISWGEAQRQSIYSDPSYQDGYYDAQPASGLAAARMAALLTYRSRDSFERRFGRKPQKAAVTSDNGVLTPPQSPALPSADYTLAAHNDGLRSSQSRPQTPAAVSAAHSRSTKVGEGSPPRPPIFSAQSYLRYQGDKFTSRFDANCYIHITRKLDTHDIARGRLLSPDEDENTALFRVLGTEPPRALVIGIQSDGLFQPAEQHEIAEGIPEAQLVMIPSPEGHDGFLLEFELINKHILGYLRVEFPEYYKDGEDVSGSAVQDFSIKKTSLFGEAEVDITRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM86</accession>
    <name>A0A4Q9PM86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_826076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM86"/>
    <dbReference type="STRING" id="114155.A0A4Q9PM86"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="331"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="527"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="653"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="748"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="835" mass="92308" checksum="4A50BBFE53EE40AD" modified="2019-07-31" version="1">MATLRAHVRKMADARKDKMGPQWSQWVTRAVHKLADDGILDTTDAQGNVAFTPDAKKTITAIRRDSLGPVVPSVNLEHKIWKDVTRRFSTVGVKRPRRKSAAAGQADEDDGEGRPRKRRARKSLSSYTKAELEAELKAALQQLEESEEADSAEQEDVVALREELKLREQEVHELRDEVARLKTQSEHDARRVTIGTSMRLVTPPPTERPAPSSAGSGRPATNHRAGDPMHGVTRTLSGSLISNLTRRPTPEPSEPGSQYAEIEGLVFDNVQDDDDFSSLSSVHGYDDAVSDSDIIPHEVGLETSQSSSNLMTHDMESATEHHGTDAHIEEIAALKKELQAHVMQLSQVRGEHQRLLEERDSLRSSAASREVELADLTAQLQSRTTTLQDTQLLLVKLEAALQTERTEGTDVRSALQISQAALEAERERTRSLETRHSSFQEELSSTQSALKTLQRTVETFESSHDQARSELQQTKTLLASTQQELAESLRGIEAVVVSQQALADRARGLELDLERSLAQTSALVSDKENLERIAEALRDTVDQLRTDLTRAEDDVASTTTRLKQSQDVIDELRASREQAQLDAAASTREAISLKVTVSELESSLGSLRFQLEDSIAETARLRGQSEAEQSSRRTVESMLSATKASHDKLVSEMAEKALRMTSVEEELNQTRRALDDTRCQVEVLKKEHDRDAAAHAEALEAARVKAADFRIQLDGLRSQITSLSGELRSVSSAKDSLSTRLEEEVAHSAQLQEDLAIARDDVQDAEEEILELREAKAADEASIQSLKAGLARLRQLQMDALDEVDNKMVSAHSAPIPGHRRRSSIASRQSIGQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN87</accession>
    <name>A0A4Q9PN87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_825187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN87"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9037" checksum="18D3CB760081DE61" modified="2019-07-31" version="1" fragment="single">LLTIFNRGTETWGIRVRDRRGHCTFRTYELTRPYTAIPRHLFTSTETGPGTQPSPPHTEGRARLCSGHTSPKRHPLLPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPT5</accession>
    <name>A0A4Q9PPT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Sulfate adenylate transferase</fullName>
            <shortName evidence="8">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MET3</name>
        <name evidence="12" type="ORF">BD310DRAFT_968728</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 8">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="8"/>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPT5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPT5"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.10:FF:000003">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="11">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="10">
        <location>
            <begin position="175"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="9">
        <location>
            <begin position="396"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for oligomerization; adenylyl-sulfate kinase-like" evidence="8">
        <location>
            <begin position="396"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="198"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="292"/>
            <end position="295"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="8">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="575" mass="63919" checksum="A8965A4737F0101A" modified="2019-07-31" version="1">MANTPHGGVLKDLVARDEHLRDNLKAEAHTIPDIVLTERQLCDLELIINGGFSPLEGFMNEADYKNVVDSLRLADGTLFPMPITLDVSREDIDRLSLAPGKRIALRDPRDDEALAIITVDDVYRPDQVKEAIQVFGADDPAHPSVAYLRNKVNEYYVGGKVQAIQPPTHFDYVALRYTPAELRAHFKKLAWRKVVAFQTRNPMHRAHRELTVRAARQRQANVLIHPVVGLTKPGDVDHYTRVRVYEAIMAKYPNGMGHLALLPLAMRMAGPREAVWHAIIRKNFGATHFIVGRDHAGPGKNSQGQDFYGPYDAQDLVMKYHEELQIEMVPFQQMTYLPSTDEYQPVDEVPKGVQTLDISGTELRRRLKTGAPIPDWFSYDAVVKTLRESYPPRLKQGFVVFLTGLHNSGKDAIAKALQVILNQQGGRSVSLLLGDTIRPELDTPFSATPEERSKNLQRLSFVAAELARAGAAVILAPTVHTQAARDAIKSTVLSQAGSGANFFAINVATPLEHCEANDRKGIYTRARAGEISGIPGVDEAFEPFERPQLTVDVTKQNIPEIVHSVVLLLETESLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQY1</accession>
    <name>A0A4Q9PQY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1040273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PQY1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF54">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1663"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1237"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1532"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1604"/>
            <end position="1637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1735" mass="188586" checksum="6E887CB58BAD85FE" modified="2019-07-31" version="1">MDGTRLRQSWYAALDNAQAHFRQLLTSHSSSEWKRVPVANEAASPASKGKARASDVPELTDVIIHRRPSNSGDNTYRAVLEVPIGDDPVSLAAWKSVLVTPELRKEWDPAVESAQLLEMFDLATRISKVNFSLGWPANPRDAVTISRTFNDATTLIDISTSLPRSPDEPTYLRPSPPYVRSDVALFGWCIQRIQPQSIDPSQRSGIARLRITCFWQHNFRLVWGFTSGSSLVQQLAAMTVGLYKTVQQRGKRVPLMTGYGNGVSIERVRFAVDREALTVDYSIVPEEDEHPQPAEQSVEELHQIREARRLTRSVEFSLPSAHGWDVQLSTKGSSEQVSQLPWTAHATRAPVSSPTAELPSTDIPKFTLAVKHAELPNDHVVLKVRVTIELSGPSTALRLNGIPQSVEELEPRDPASYFVSQQMFQDASSMAEQSLHTQSSVATMATSTSRASTVGERPQIARTPTERSAAAEKSILSRVKRNYIYFSSLLQEPEAKWKQNVEARGVSVSQLDSIDPTLVVYRAEATFVGISLWDLYAAITTAGARAYWDKQYDDAVLLEDVNELTELWHYKTKPAWPVNGRDMVVLKTVYKSPTTVHVFAFSADDPSLFPQIPPVDPNVIRTQVDLQGWAIEALSPNTTLVTLLEQSDPKGWSNKASIPQQMITAVAGVGEFAIKCGGPPIVTRLESAKANKLRYDHERGSFRIEYEGCAKRRTAGEGAPADGRSSSNLPVIECEIRCDLDTWASSLDIVVDPPPQSIIALRRHRFSSGGGGLWLTITHDAVFSEQERLQTIIRRGPMSAPKDKGLVMVNGAKVEVDMEEMPDRDLKNLTKQKRVKPTRVPLDQPPVISTIRKRRAEWDAHKDIQGENGNGRSSVPPSPSKTSFTTTSPSFATSVSKFFTFAVEQATATTQQAVAAISPAMAGGEDAAPLSSKLPMQCALDALAFVQDLHASPHGDGWTLVSDKDFPVQRKIFPDVSPVIPVHKGKKVIEGVAAEEIVSVLTSYDCRKQWDTRFDSVSVLEAYGADAHTAFVIMKGGFPFRDRGFYLASLIARGTTSTPASRRSTVDVEQLSGEQHSRSAIFCVSASFSPESVSHFASTKYNAHNLPVGRVFLDAWVLETLDPYSAENYAIPSTRCTRVVAVDYAGSIPAAVNSMINGMLPKSILAVENYLKNLSPSPSMRMPAAGFVLAPSPEDKLRSQQSWTLRRRDASRTFLLGGFHPASRIYSSLMILNGAASASPSSTKDDRTPRPSRIVTNPASPLAQSPISLSTDETSETLEPSASESRLRATRSRSPRARDVQRSPSIFTPRGEVRLPVDLLVSELIVDSKLYPDGYDVQMRSRIEKNTKSQLALPGPSSDSAKDDAGADAEAALPVACAAYTLPSSPLHSAGLNVDRPPRHLLRFTLPTAQYQMTTIVDPLTGETRRAPPKPQWLLDLEEGRSIVDVRVTPAPAAAGNASSSAKKTVAVRVNGASVPVLSEKESLTALGRDELLDGRAAKMDVLARSVSAEEQLPAELQTPLAVAQHLLEAPVKASEGPSGAPEEQEKEGGGAASDATEDAAENQAMPLEPPAETHAPESAATGFMRFLNLNGYTQLRFGASRRSSAVLSPTGANSEGTARTPSGSQNDGSGTARQTSGGEGPESGAMLARAQTRTMAGTGTTYPLSTVVVVALIAFLVGSLLRSLLSPADFVYVVTDEKEMGSVGGAGWREMKRLLEVKYLVGGWDFQIAVVRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR35</accession>
    <name>A0A4Q9PR35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_822851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR35"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18595" checksum="B46030C6143B60AF" modified="2019-07-31" version="1">MQFGCFNLQSAIDENYDTLLGAEQLAWEASINLPTKLAVVFCFPGYPLYNRQVTVLTAHRVPPTRGKMARIIAQEMRKFLARTEYQRPVCWYGREVSLADLFLGYMQHVSRGSLQAQIGIRFCQLASWVPECVSFPPSIHAQQADLHLRSGPRTPNTSRHIAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRD5</accession>
    <name>A0A4Q9PRD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_592596</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU56931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRD5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="312"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="11"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="449"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="569"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="636"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="457"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="478"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU56931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="680" mass="72491" checksum="4B46CF4E258EE0B8" modified="2019-07-31" version="1">MVIGGFVVAFSMFSLLVKEKLYINEVVLGTACGVIFGPYCANVFDPRSWGGDLNTITLEVTRITLAAGLFAIGVELPQSYLADHAKSLLVMVVPTMAFGWLVVAAVIFVVFPNLNFISSMVIAACLTPTDPIISAAIVGGKFATKHVPLNLRRLLSAESAANDGLAYPFLSISIYLTIESSTRVAVGEWFLVGWLYQVILGTVIGGVLGLGFSHFMKFSHRRGFIDRESYVAQYLALALFTVGITRTLGSDDLLAAFAAGSAISWDGHFNTQIEDEVFSSVIDLVLNCGCFIYIGAWMPFNMFNAPELDLTPWRLFIVFLAVMILRRIPPLLLLYPWVPEIASWREALFSGHFGPMGVGAIFVSTLAVTELPTPQSPPQDQAETLAATLQAIVSFVVLGSIIIHGLSIPFFSFGRNVRSRTVSLSHTWTSRTTNTPDWLLWARRTPAEITRPGSPVTEERDVERGAQELNPGLASTMSRDDAKTEERVPELGPAAMLSDVTAPTLPPAPPLKDESASAVHVPSEDATADDAPTATQLPSLTRNVPRRTLRSPNASCVLVASVDDLAEHLPPSGALTPDDVSVPHTGSGTQTPGSPSARTVHFPAEDEVATHLAAKDRAPTCTKVVRFPESLTGSAGVIKDAPSVRPPGADSGVVGEGAGGVETSEADGALGGKSSSVLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRI7</accession>
    <name>A0A4Q9PRI7_9APHY</name>
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        </submittedName>
    </protein>
    <gene>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="152"/>
        </location>
    </feature>
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            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
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            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
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            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU56992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
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        </source>
    </evidence>
    <sequence length="413" mass="45630" checksum="5604B34EA80D8B62" modified="2019-07-31" version="1">MEVDPHPSADVSDGDTTDSEASVPLAILRPSRVPSPIPFSSAGLPPPVRRVRLILGPNPSQPRSSRESSPDVPLQSRTSSRTRRSSSSRLNERWHELGWDTDNSELTPLEDSSDEGESEIDLPESDEEQDAEDAGTRKLSIKIPQRPPPKHRWQCRTLGCANLLTQGTHWKNCDVCRTATHRLRKQERLQMRDNIMGRAIANAVRTAVREEETASRRKRKLPMADDDAQEESGGDLNRLGEMPAYQHFAALLESFCTRFAQFKDVQTRYVQLKALSGTARKAMVFKFGGEYSVIADPSGGSVDTLVGTVIRNVQAALGLLFRPAGFLSGPEDSVVAVLSCEFVAWIPLVGQKQQPAATPQPGTAAQSSDQADSAQEARMEVTMTGELHVCVAWDRRHKFFPGQRIIIRFKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
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    <name>A0A4Q9PRQ1_9APHY</name>
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        </submittedName>
    </protein>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
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            <end position="136"/>
        </location>
    </feature>
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            <begin position="120"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="28896" checksum="3F9AC7C3A4167580" modified="2019-07-31" version="1">MDSHAEGTYNLLLPLSIFYTTHQACHTSLSHTRRSLGSPRTLRSKTQGAWSRNRIPFNDELADLCSSVTTGDLLVPWLPIAGPEKGADMLRMPLEAGILAALLAVRMAKCMRVSPEEEGDRPSMRDRCETETSHTHDKVGQQAYLAPITYIHSRQPNKRITPRLVLASRTEDIAEIDGVSCEVLDPLAVRGHSACISGKRGDCRGNSKGLSFVPGLELVVRRTLSALARCEEPEPCEKHIAGVPLDEDDYRSELSTLARRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSL5</accession>
    <name>A0A4Q9PSL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_978208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSL5"/>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
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        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
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            <begin position="197"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="25989" checksum="C5204EFE2ECFFBC4" modified="2019-07-31" version="1">MDVDPSSQPRSRSPPSGAIVSHHGEIRKKRRIVSPESSEETIGDHRGTGRNTARSQIAWPREPSGTQPSGSIHSQEPFKPSDTGAVISSEGYRGWREPDPEPDLTPTPSEEELPDPTQPSTDSGNLSDRQNNKRMFPRLLRKEDTLMSIDPASQPPDPSSEDTELRPDVSSANLATMLDHLRQKQREDLEVFAKNIRAHIEVECADLKNELTRVKAELVDLRLQYQRMQNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTA8</accession>
    <name>A0A4Q9PTA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_929073</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTA8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTA8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="519" mass="56092" checksum="BF977CEF55DABD5E" modified="2019-07-31" version="1">MEKVVFGDIESVDRDPGSLQDTAADTAASKSDQRLRELGYKSEFRRDMSLFGVLGISFCAIGILTGMSSAFQTGLFSGGPLGLFWGWNICSLFMLFIALSLAEICSAYPTMGGLYFWVCKMKPDMPMLGFCTGWIYSIAMVFTGTSGNLSVALYLASLAEVGQGRTLTRVEVAAIAWGVNILSGVINTVGTKAIGHMSSFNLWWTLGGTFVLVITLLVKAPVKNSAAFVFTDYENFTGWSNRGFVVLLGFLQAVYTLEGCETAAQVAEEAKSAEILAPLAVVGSIAGSWLIGLAYMLALLFSVQSIASVQATSFAIPIAQLYYDAVGKRLTLMCLTVVALAQFMAAVTAFTASSRLFYALARDEAFPLKGQYMALNRFQAPYVGVWTSVLVGCIISCAYIGSAVAFNAILSSAAIAVMLSYLQPIIIRVFWPTTSLPERGPFSLGRWSWSINFASFLFTVFICILFILPTAHPTTALNMNYSIVAIGAVIILVGACWVLWGRFHFVGPVKTVIDEKKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTU1</accession>
    <name>A0A4Q9PTU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1017227</name>
        <name evidence="1" type="ORF">BD311DRAFT_226823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143406">
        <property type="protein sequence ID" value="TBU30424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTU1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTU1"/>
    <dbReference type="OMA" id="NDWIRRF"/>
    <dbReference type="OrthoDB" id="2585512at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU30424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="55688" checksum="63AE8FDCB91FA81A" modified="2019-07-31" version="1">MSSPAQFLDLPIELLPSIVHHIVRPSHLAALCLVNHSFYKFTITLLYERVFIYAWHKEGKSKVIKLFRTLADYPHLAKLVQQLGVCAKQHQHIAFEEDSSEHGLRTHADSATVIRDFPKALQSEDHDLILEHCLAGIRNCINLRACTWTRHGSLTSPVLETLVDCARLQELEINGENSGFYDPGILPRFSHLRKLALIMPSAAVIGILSPWTRNTSQTLNHLGVICKSSTRFNDGVLHEIAPHTTNLEHVYLVGCPKVTHDGLWALLSTNYKGIVGLGMEGLSTAFDMGVFSDRCNRAGTLSRLRSITLTVDEHTSLVEWQQEVLSLLSNTPIQYFHISTVGGHVGHRLSDDFCSAVVSAHGHRLTRFSVHRMRMSIGAIADICRRCIVLEQLFIVVEQNDLDALGPCLAEAPKLRAVHVNRPLDFGSEDVPKHSYSQILSIVRQCRPTVRQFGFNTRVFQVERTSKAAEHGSIQTEVTLSSYENPEIPEQFLVVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU05</accession>
    <name>A0A4Q9PU05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_762714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU05"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="1">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="293" mass="33350" checksum="E042367180C0D0F6" modified="2019-07-31" version="1" fragment="single">RAIAHEEFLRSIGLSDIPPALDYTFSSYGIRIQLPVIPLSLYLPSWTRYDRKVPQGWYLAILRCEHADQPGHLLGRVCRIYSVSSDVQVLSSGYVCVADRASPERYPRLFALSPAVIARCRPHLEVRTLYMFHPERPADTPGRAPRTWFPRTLSFRVLASTRDALQRHGYLVNLQEPDQDTPRSHLLTLSSTDHTISIRYEYTLDRRNFVEGQLIIVAHIGLVSSASLASPEEAYSADPSTMTWSDFRTWQSLSEQTVIFSAPGDRSFALKLGADFVWASHYSLVVKYYKDID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUH2</accession>
    <name>A0A4Q9PUH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_967773</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUH2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUH2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="278"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="502" mass="53615" checksum="8A25B9DC2513444B" modified="2019-07-31" version="1">MPCMDFLTLLSTGSNSCGQLGIGNIDDVHRFTPCIFRGAALGSLPEHVVGIEQIACGGNHTLALLRTDDGKTKLWGCGDGRKGQLGPSYTSEVREKAENAAVFRRLDLGAHLERAGILSGISEEYNTRLVAAGWETTYAVLSYPNRSDVLLSMGSDDYGNLGVDTNTQRTRHDIYVVDLRRAVRASDDSMSTITILSLAAGPHHTIVHVRLRDPDGSSVTYFAGWALGRHHTVYMQTSGKLVGLGSNRKGQLDELSTLDDVEQVGCTWNGTYALLRSGTVVATGSNTHSQLGRGPTVLVPQSALQPVAFLFSSKTHRVASLVCGSEHVLCLVDAGQHGLHREVWGWGWNEHGNLGTGGTADTDVPLRVWPPASSAASCANADADDSTTSREGSGNQRHGDVLNVWAGCGTSWILVRKLGLWIVHRTDHVVSGALVAHITADASYSCPAAVSGVSEPIRAINDIRYDAALCVDKAVEQGFAAALHTHYQDSAAAYAYTANFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUQ8</accession>
    <name>A0A4Q9PUQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUQ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="61079" checksum="87BC51904107C4A3" modified="2019-07-31" version="1">MTSPKEVAFAIGMQSIQPAHDQQPRLNFDVLRMVCNCLTDVSDVLSFGTTCTALRKGALQRRLRMSPFILSSSMSVDRLHSLLFADEAARAPFLYGVACPVFHFYSQDVLIRFAAILKAATNLKSLYVPARTGNPIITAICDLTTLRELHVLASVGDDSLRTILKNLRSPLRYLHVEGYELGTFSAKFLHNELPHLGQTLEALKLDDFPLDIPASSVKTRFTSVRSLEADEIDISSDLGQLDVLLELFPNLDTTFALGPPGPTIPVPEVERRRQRNMETQKTRTWPRLDRLVCDARMAYILALRCPIRLMTIDTTNVFDGRRYLAESLRYNAPQQLHFSLELNDGLALLDWLFPPEAAVKLTRLVMFFNHQISRRPQTLHRASFQWQELLGRLIVSIKHLRLTHLRLVVCYHVFQSMSKRTQPNMGVDEDFVNTARESDLLPAATAFLEAMPSLEYIFLTTCGRTYVPVGRRWEERHKWLSSKAWRVAGRHEGPDVPSAATGMLVELSSEAAEVIIDREEFQLSLREEVQVKACISPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV11</accession>
    <name>A0A4Q9PV11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV11"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="67404" checksum="47C83C8481516A39" modified="2019-07-31" version="1">MRVPNSPICSLPPGLLRLLGDALLGIQEWTADEKIDSIGLRTLPVLARTAHFLCEPALDALWDTLPDFGVSVYLLPRDAWDMETVDVSRAPQSFHYVARQNLYCIYSGSHPSSVHDPPLTDEEFGRLAYYTPRVKRVQELCSLFPSRFHGYITFETSILAALASRWSTSQPLFHNLRVVRLNPAHDQYKVYYRYFHVLFGAQLRHISSDATAFSNSKDVKPEYYRQMLMRLQETAPLLTRFELKVDAEPYSPIIHSAMYSAIYSFKHLVSVRTGALPMDMPTIRYLAALPHLEIMEIRPADSISPRDLHWLGTTRLAVHFPNPREVHLQHHVAPDPLATILLHIHSARLETIHITAVTQDTPIPMGHALQLLSVVLSRNGSAIIKQLHLTIPVDRTSDVAMIDQHFEPLDRLGHLTHLRLQFHCPVIVTEAALARAAEAWPNIRELTIYPYFYQTESLVTHGCLIPFAQKCPHPNLLGLPVDARMSLLPADLRQSRAGLADMICPLERLEVGMSESLFSEPPMEVATFLLDIFPRLEGVASQYPHMFWKTVNMDCIPYLAQQRGRERRRSLDGPVRKSWRIGGRRRKRQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV58</accession>
    <name>A0A4Q9PV58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sec63-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_958932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PV58"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18020">
        <property type="entry name" value="DEXHc_ASCC3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF13">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="176"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="398"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="1035"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU58370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1488" mass="165908" checksum="1D4791C07B472659" modified="2019-07-31" version="1">MVGFDNIELSMELLENRHEVAQQLSEYLQGGNQAAEPVRVSGYGEERKREELFTVTGILDPGEARRRMEETLRANAERPLFSGTAHTAPEVLPHVYTSSSIMQGNMLSHTGQRYMLPIGTTRVAHEEYEEVTVPPAKVVPPRASERLISVAELDPLAKGSFPGYTSLNRIQSIVYPTAYQSNENMLVCAPTGAGKTDVAMLTVLRVISQHLKQLAPHGNMAAAVARDNFKIIYVAPMKALAAEITRKLGRRLKWLSISVRELTGDMQLTKQQINETQIIVTTPEKWDVVTRKPTGEGELASKVKLLIIDEVHLLNDERGAVIETIVARTLRQVESSQSVIRIVGLSATLPNYIDVADFLSVNRHTGLFYFDSSFRPVPLEQHFIGVKGKPNSPTAKKNMDKVVYDKVSELVHEGHQVMVFVHARKETVKAAEAIREEAQLDGTLEEFSCQEHPQFEYFRRDIAKSRNKEMKQLFDLGFGIHHAGMLREDRNMMERMFEARAIKVLCCTATLAWGVNLPAHAVIIKGTQVYDSSKGAFTDLSVLDVLQVFGRAGRPGLESSGVGYICTNDEKLSHYLDAVTSQVPIESRFVAGMVDALNAEIALGTVANVHDAVQWLSYTYLFVRMKKSPFQYGMPWDEIANDPTLGAKRNSLITAAASQLAEARMIAFDRGTGSLVITDLGRIAAKYYIRHKSVEIFIKQFREKMTEADVLAMLCDSTEFDQIQVRENEVEELKAFMEEIPCKVKGGTDTSAGKVNILLQAYISRFRPEDFALVSDQAYAAQNGGRIARGLLEIAISRKWANAASVLMGISKAIEKRLWPFDHPLKQFEGLKAEVLHNLQRWADEYDVAELAEMSSEELGKLIHLNQKHGEAVRNAAKQFPAVHITYSLRPLGPDVLKIAVKVERKYNWSSKVHGSVEPFWLWVEDHEGTNILQLSHLVFRQTTTFVDVDFVISVNKDKPPPSVTIRYVSDRWVGAEQETVASFEDLIMPASSESHTPRLDIPFLPLSVIGNPALQEAFSHRVHGLNAIQSQVFWSVVRTRSHALLCAPTGCGKSVIGQLAVWETLLNSPNDAWALVVAPRRSVALDLRAELHSATRATETSVELAGADHLFDGPSRRTVRVVTAPDLFSAMTRRPNAKQALSRLRLVLCESLELLDAVYELGVSLLLHATQAYPVRFVGLSNSLNDPTDLAAWLSVDPLALHSFRPSDRDQALAVIMHTFTIPQSAALFKAMAKPAHAAIRAAPGEPAIVFVPSRNQCVPVALDLITQCALEMLAQGYLPDDVSIERLERYLSRLQDYNGLKDFITRGVGFFHAGIAQPDRLLMLELYAEGLIRVLIVPRDACWTLPVRAVTVVVMGTQYFYVPPGSDERQLRDYPLEEIVRMQSKAVRHNGAGRFYLLCQAEGKDTITRFLNDGLPLESKLLETETLRAWYKDRRKDGAIADKQQGVDALSFTFLARRLVSNPAYYDARSIAVNELLSRIVDKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV69</accession>
    <name>A0A4Q9PV69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Citrate transporter-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_819312</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV69"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV69"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43302:SF5">
        <property type="entry name" value="TRANSPORTER ARSB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate transporter-like" evidence="8">
        <location>
            <begin position="30"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="572" mass="61090" checksum="5D8F4BBBF06DA9A7" modified="2019-07-31" version="1">MIFLLHGQIGVRDRATESTSRRYFHLNYISVPLISVLALLASGVFDRQTIRDGVVGTGGIRPLNIMALFISLAYISISLDATGLLRFLAFWVASKGGSSGHRLYMYLYVFFLLCGVIVGNDPVILSGTAFLAYFTGVTGITPPSAWIFSQFAAANMASVVLVSSNPTNLVLSGAFAISFLSYAAHVVLPFLAAALCVFPLLLVLFRALPLPSLSGGHPQRETERDLIPKRIYIGLSQAEVRATLVDARGAVFGSVLLVVTLAVLVGVSTVGVPVWEVTVPPAVIMLARDTWFDWTTHLTRATPKAVDESRRTSSVGEDVSENMNEMPADTHENVDVDNAGHEHHELQDLSARAPTVVSPSPISPSSITPSAFSLKPHAPVTLTPLLSHALSRFAATFPTVTHVLERLPVALLPFAFLMFILVQGLTTKGWVELFARWWGVWVTRTGVLGAVGGMGFLACVTCNFCGTNIGATILLGRILQLWLSSSSSGVGTDAGARDGAIYALALGSNFGAFTLTFSASLAGLLWREILGQKGIHVGGRQFLVLNLPISFVAMAVGCAVLVGQVYVEHGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVY2</accession>
    <name>A0A4Q9PVY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_819097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVY2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVY2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9890" checksum="4997C210DBA7FC0C" modified="2019-07-31" version="1" fragment="single">QPSTLGLIFNSSAPNPITPAAKSPPIKPDFAKARKLKLYKPGASNYDDLLPPNYIDLVPKEALEQFKSESEKFDWAKIPEWVPPKELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWF8</accession>
    <name>A0A4Q9PWF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWF8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="478" mass="49105" checksum="2C3458C6F77A7B95" modified="2019-07-31" version="1">MPPKPRPVRKPSTSSGNPATAPGAVKDASAASASMPPPPDPGPPLGILVPEITALSSCLQTAVIKTGQIYGFYTDVKRLGIQQYAPKPPRSLTSALGREIVKYDQLCDAMESHLLRAITVLQRDLAREEQRIKAEEEAAAAAIPKPPSPSPMPAPTPAGSPTQTQIEPLPDGNLRPRLSGVGVNVARRQSTISLSSLSRPTAPHKLDLSASALRILPDEMIPSGLSSPVTLAPRSARAPSLPPELVMLGDPTGRSVDIDLTLDNDMDMTGPSASGSHMRSMLHVDPTAGSSADKPIELDLDMDMDVQFFADDPDAGAEGANASMFGPAPISGSDQHAHIIKPKQEEQLDLDLLGSFQSVQSTGDDMFAPFGNSTPGGIPTSSAASTSGAQKAPLGAPSPGTILADLTGTSRAGDGSGVSTSGQEGSFDFDMSTFDSNFLAGQGGGDIDMSGMDDIFNLGVNPADSSTDGGAPGGSGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWY5</accession>
    <name>A0A4Q9PWY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWY5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23571" checksum="A62DBDFBF32894FA" modified="2019-07-31" version="1">MDSSAPRCCLLIPAYAPDVTRARRYTPGYGPLIVFLLITDRRRHRRHTSQLTIPPPVTPPVALPMTNPRSSLVCPFAVAVCCDTRTRPPPICTTTRIMHHHHSAFAFIFVSPSPCRRPIDDDDDVVAYSYTAALTSTCNQRTIVLYTKASLHSSFTAPFSPQVVHQVTFCITVLVRKSSLPFPPFACTPRLSITSNAPPPPMSNLAHPSMFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXJ3</accession>
    <name>A0A4Q9PXJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ketopantoate reductase PanE/ApbA C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_925603</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXJ3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXJ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF43">
        <property type="entry name" value="KETOPANTOATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="2">
        <location>
            <begin position="229"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="364" mass="39150" checksum="963E2712A17785D5" modified="2019-07-31" version="1">MAVNMASDGLIDVCVVGFGGIGALYAFALDKTSKVRITAVCRSNYDALQEHGLDFESDRFGNYTAWKPYRVVQTVEEAADRTYAYIICAFKCVPEVCTTPALLAPLISKLAASPPADATAPSGDRTTNTTFVLLQNGIGIEDALLDVLGVISAPTTVISGCCWVDTTATKGGRRIVQHGNERLVLGYHRPTSHTAVHFSEETAKRSLDELVALLRTGGSVVEAAPDADVARWRKVLWNASFSTICTLARTHVGDVLALESSRQVLKDIMAEVLTVARASLTPSPAMDEELSDAVIDRIIANENSKSVFRPSMLVDLDYGRPMEVEAIVGGVLRRARAKGVPTPKLDLIYAALSVIQSNLIKARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXZ7</accession>
    <name>A0A4Q9PXZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_924657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXZ7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXZ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050031">
        <property type="term" value="F:L-pipecolate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF46">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="433" mass="46882" checksum="FBFFE8609B5B111C" modified="2019-07-31" version="1">MVLVHGDTRIVIVGAGCFGLSTGYHLLKRGYKDVTILDRSPVLPAPDAASTDISKIVRSSYADIFYTRLGREAIAAWKETDEWGDTYRECGVYCATEGADSYIAQAYQNDITVNADVQTLLTPEAIRNVFPTTAELGLSDAAKGFLNRDGGWAFASQGIQRLMDKVAALGGKIIPGKTVSELTRTNKRVSSVRCTDGSVHEADLVILAAGSWSASSFPDLGLDGQCLATGQTVAFVQLTSEEAERYRACPVYLDFHSGFYVFPPNKDNIVKCAIHSGGFVQKIKIANSDVYVSTPRTVTSDGVDGLRIPRAALKALRTNLARIYPEIGSKPFFGTRLCWYTDSADDNWVIGAHPEIENVFLATSGCGHAFKFLPVIGRLVADAIEGKLPPELVKKFAPGRAHEHDAIEPSIRLAPPANLVLDELCTPEDLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYN5</accession>
    <name>A0A4Q9PYN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD310DRAFT_923939</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 25">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYN5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYN5"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="45"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="193"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="452"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="552"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="634"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="681"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1054"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TBU59897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1142" mass="127235" checksum="50F87641BFC9133E" modified="2019-07-31" version="1">MAVYGEEEDWGRVAQTHWRGLGLTDPIKSVEDKWLLLPAFLKVKGLVKQHIDSFNYFVDVDIKNILKANNKVTSDVDPRFWLKYTDIVVGFPDRTDADAIDKSVTPHECRLRDTTYSAPILVTIQYTRGKTVVRRANVNIGRLPIMLRSNKCVLTGRNEAQLARMTECPLDPGGYFIVKGTEKVILVQEQLSKNRIIVEIDPTKGVVQASCTSSTHGGLKSKTYVATKKGKIYLRHNSIHEDVPIAIALKALGIQSDKEILLLTAGNHEAYKSAFSPNLEEAAKLGVFTRHQALEWIGSRVKVNRRVVGPRRPSWEEALEALATIVLAHVPVHGLDFRPKAVFVATMTRRVLMAMDDEKMVDDRDYVGNKRLELAGQLLALLFEDLFKTFNANLKAAIDKVLKKPSRTSEFDAFNTMQFQGDHITAGFVRAISTGNWSLKRFKMDRAGVTHVLSRLSFISALGMMTRISSQFEKTRKVSGPRALQPSQWGMLCPSDTPEGEACGLVKNLALMTHITTDVEEEPIIRIAFMLGVEDISLATGAEIYGPHTFVVNVNGSIIGLTRYPARFVSNFRRLRRAGRFSEFVSVYINHHHRTVLIASDGGRICRPMIIVENGRPKVTSEHIAQLKQGQLTFDDFLRKGLVEYLDVNEENDSYIALYEKDIVPGTTHLEIEPFTLLGAVAGLIPYPHHNQSPRNTYQCAMGKQAIGAIGYNQLNRIDTLLYLSVYPQQPMVKTKTIELIGYDRLPAGQNATVAVMSYSGYDIEDALILNKASLDRGYGRCQVLRKNATLIRKYPNGTFDRLADAPLDENGQVQKKYDIVQTDGLAGVGERVDPGDVYINKQTPTNANDNSFTGQAATVPYKNTPMTYKSPVAGQIDKVMVTDTENDQTLIKVLIRQTRRPELGDKFSSRHGQKGVCGLIVNQEDMPFNDQGIVPDTIMNPHGFPSRMTVGKMIELLAGKAGVLAGKLQYGTAFGGSKVEDMSRILVENGFSYAGKDMLTSGITGEPLEAYVYFGPIYYQKLKHMVMDKMHARARGPRATLTRQPTEGRSREGGLRLGEMERDCLIGYGATQLLLERLMISSDQFQVDACEECGLLGYNGWCPYCKSSKKMAQLTIPYAAKLLFQELMAMNVVPRLVLDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0Q1</accession>
    <name>A0A4Q9Q0Q1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SIR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_922772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0Q1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0Q1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="11">
        <location>
            <begin position="184"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="481"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="542"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="547"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU60599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="579" mass="64202" checksum="D55F1A8042EF70EB" modified="2019-07-31" version="1">MPLTPPTPPTPLAGGPSPAPRRKVTRSLYGMQVRAFVEAAEVVDADPEVIEDILDGFPLDDPSDDAEDEDADVDVEGGPGPGTTVRNEESDIEDDPEQDEFAAYLEEAQTAWTAQEVKAMKYLLKEHGMAAFVNEYVVQRAIPIPMLLYAFGVCLCKELRMKQRRTLMYFLRVALSRELESRERLLTYNTIDDVVNLIKASKRILILTGAGISVSCGIPDFRSRNGLYASLQENGEYDLDDPQQMFDIQYFRENPAVFYSFASKIYPSNFIPSPCHRFIKLIEDHGKLLRNYTQNIDTLETLAGVQRVVQCHGSFATASCINCKVRVPGSEIADDIMNQRVPVCKVCSVPQPPLGATKGKKKGKKRKDGWDSDASDEPEPPLYPPGIMKPDITFFGEKLDDVFDRSLLEDRGKVDLLIIIGTSLKVSPVSDTISHLPHSVPQILINKTPVRHINPDVVLLGNADDIVLHLCQKLGWDLPEPPLPATSTHGDGDSNSRLDTPRPNLRKRPSAGFEKEPRRVGNSHVWLFEGAEGGKWVEEIERKYQQTASESTSAASTPLSSPPASEAGDSRQMKKARVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0S3</accession>
    <name>A0A4Q9Q0S3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_957387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0S3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="191"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="638" mass="70951" checksum="73301AEA4F0E080E" modified="2019-07-31" version="1">MDGTLRARSRRGVRCGGGCGEETRVRDVDGRAGRMRWAQGETGPRLGHVWTTTPKLEWACLLSATLSANSTVRPLSTNTIVCFSSNRSLQTPRTRRVRFCTPPIPPSANRDQFLPLLQREVKRFQENYGRDSFQYGSDGWRVLVHPSADVDGPHFSPAVSSLMNQVHMNEATLSCIRARIDALSTFLIPVLRLPREVLELIFKVGSRMPQDDPILGSSIPRPFPLVVAAVSRQWREIALNTPDLWTNIVIKHPRPFGWIPLCLQRSCGQPIDITIDTRSTPLLNTTAVDQLIARFLPHIQRWRRFALTTSDPATIYAVGGRLANASAPMLRHLQLSLSGSSGNQEVLLHEILQGGADALTSVRFDSLSTPWSAPPLHNLVALDLRWLWHQTRLQYEQFRSVIAASPNIRALILRGTYIHLHAGRAYPPLHIPTLRYLELSGDTVCRMSSLLETPNLQELTLANLDETEFREFVASLPLPTDTSAAASASPSGSATGLGRYPALRNLSLLNASMCTPTRRFTRALPTITHLTVINSATSKFLQLFRKEHAGPDAHGYGYGHSHSHSEGVLSWPHLKKLTLVDDEVDYFLLHGVVRERAALGAPLDRLILNAPFIHDDQLVATLEECVNVDIVKDVDLDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1M2</accession>
    <name>A0A4Q9Q1M2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_922565</name>
        <name evidence="12" type="ORF">BD311DRAFT_658749</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the histone H3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1M2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1M2"/>
    <dbReference type="OMA" id="YLELILC"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="8 9" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="46"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU30458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU60474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15513" checksum="B56755C6C2E6D239" modified="2019-07-31" version="1">MARTKQTARKSTGGKAPRKQLAAKSQARKTAAAATGGVKKPHRFRPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEASEAYLVSLFEDTNLAAIHAKRVTIQPKDLALARRLRGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1V2</accession>
    <name>A0A4Q9Q1V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_255177</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q1V2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09391">
        <property type="entry name" value="LIM1_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09392">
        <property type="entry name" value="LIM2_Lrg1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000058">
        <property type="entry name" value="Rho GTPase activator Lrg11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24215:SF10">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN LRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="195"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="8">
        <location>
            <begin position="258"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="9">
        <location>
            <begin position="1032"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="771"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1276"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="669"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="869"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1284"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1325"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1341"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1404"/>
            <end position="1428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1441" mass="159063" checksum="25E6F2802DBA5C92" modified="2019-07-31" version="1">MSGPDHQKQQLSISSQSSSSDSATLAYMAIASDPDSDHDLDPPPTAHANGFSSSSPRPEHYASDRTPVPVKAATLGTPYDLDQRQPRTDDRPHARSEDLNHSSSWASNDPSFTDRALSQSPAPPFMASSRPGTPGSSSNHHPLPPSSSDHSESSRSRRQSMHSDSSLGSESSTPGGSQLGGGSTTTHTSTSVASTPCAACGKAMQGAFVRALGAVYHLQCFKCMDCGTVVASKFFPIDGQDGKQHPLCERDYFRRLNLICAKCGMALRGSYITACNKKFHVEHFTCSICPTLFGPQDSYYEHEGDVYCHFHYSTRYATKCAGCNSAILKQFVEINRNSRDECWHPECYMINKFWNVKVSSRRPTSLPPPAEDGEPTQPTEPPYVEEERMETAQSLREKQIRMEQQVYRIWTVLSSFEESSAACISDMLRQVSNGQYLDAIRMAERFILHVEVLFATIDDLEYHFARLKLKGMSHVREARMLCRKTVDLFTLLSHTQETGARRMGMTQELLALVTGLAHYLKILIRIALTGALKLEREQDVREAITNFLDKLHMLAIQGSNPSARRIMKRANGELIPQSDSGNLGTQGVTYGFKSLAPENAGESPFSAAPKDPLLAKVPVVHPPSDLCIKCNQTVEEDCVRLGTYQRWHSHCLTCQTCGKAAAMPTVKEPKALEDKDRDGSQAGQEKEGKPKASTARRPPANVGAFTYEVESVKETTSFGVVPTVILCTEHAHAGCRAGFQAVSRLEQYAFLLNVALRRLYVLLKKRGVVPLSPAALPGQGQSREPDEDPYRNSGDINRLRSVHLDRKLSSTARVPKRSTIVESPAGKVAHAHPSDLAHRPHEVTSGARTPAPQVAQHGTARSQKAPLIHTQQSYSQQPQRSLPSPGMIDTNVGSQVIRPAFARGNTAIKIVDESGPSSPAGVNQDEQMVGGIEDGITLADIPQLVEAAQAREQRRSLPSQSSIPYIGDLNPLQLAIVKHCAVLVLQRSPLRDQFDLDEILELVETKKSSFWNKLFKPGNDKKNVKKKGVFGVPLELLVEREGADSLLGAGRTPLRIPSFVDDAISAMRQMDMSIEGIFRRNGNIRRLKDLTEAIDRDASSVDLTQDNPVQLAALLKKFFRDLPDPLMTFKLHRLFIATQSLPTEQERNRMLHMVSLILPKAHRDTLEVLFVFLKWVASFAHLDEETGSKMDLQNLATVICPSILYSRGQNAVRDESFGSIRVVTALLENQDQFYCVPEEFLPILADEEYFANCMELPSREFLKKVDAYMRLKSGGRTPGLISPTIGNATFNFNPGTPRPEDMRSMPPRSTQSNPQFLDRPPMANPTPSDSVLRNGLSPQRQQPPPMQHSPFSYPPPTGNPQPTSQPSMGAIHSPQPRMPANMQGMQSPSPDWGMERPPGVQDPNRPSSRPSSFINTSVNPSSRTSSESPHPYVPNGQHQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2I7</accession>
    <name>A0A4Q9Q2I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_813111</name>
        <name evidence="2" type="ORF">BD311DRAFT_777086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143408">
        <property type="protein sequence ID" value="TBU30108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2I7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="5890" checksum="16B336885B07750E" modified="2019-07-31" version="1">MMERDGLDAYNGRGVEPPKAIGGHVSQRRSQCWAAAAIAARTKQGGIPDYSASTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2R1</accession>
    <name>A0A4Q9Q2R1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1037635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2R1"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="355"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="423" mass="47160" checksum="EF01FFF0897930CF" modified="2019-07-31" version="1">MATAFPTVSTFATKVAELTDTATHLRRALLNNQPKIRQIDFVLGAVSSSSFLQEWETCAEDYHGILESSEGAAIKLAATIEYYLSLLDETNDPAEIEDTIEELKGFRQASQNSAMNSKLPQIRFEHTAQWDALVIRLGNLAGTVTNAVATVGPQLQNDVNVKESRISSLEKELQMVREKRKREESEATLAQAQSFVADAWGTVGKSNSGWQYDTRARNADAKRQTRASYTERPETQQCSRQEEARIDGELTRERASLKQAVVTLREHEELDLKRIISVIVEIQMRLTTQSGLLRDVFSDVTCKLTNDSKNYLSALLKVHGNPTPSNQLDCRNAKQRAMSSSVVWQKRAQNLISPVQDDPLPFQDAELEPPQSHGAKTPPRGSSPPDQPRARVEDDVAEEEPEFGSNDPTGTLPEPTLEELTLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2X1</accession>
    <name>A0A4Q9Q2X1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_813315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2X1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2X1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="664"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="698" mass="74400" checksum="B0D9C76C1AD016B2" modified="2019-07-31" version="1">MSNTHKQSLASDSTSTRALNQKSPRPAFINLDECKPIISTTTANTSRNSSTHGTTAFVFTSSRILRALQDQDETCHHQWYPSSPSGASVPASPYTSSAASSPSRTQRASLTLSQLVKHSEGAVDARSLLGPKMRAAGFVNMSNSHFRRANASCPSSPLSASHDNLVSAYYALPTPRDPPDFPPMRFVENKLDWYPNKPDVEKMGSTSLASSGPGLSEYTPGPHNTSASLSTSAYSARRPPLRNHLSDPGSGSSGPFSSSSSSTLVSASVPLTAVEEAEEISAWRSSSSPGSSSSRRKGRARRRRDEPVEYPFPATCGFPRSQRSPGFCGSRASSATASPTIIAPIPPAAQPASQAGSLRSSPPVSSSNRLAASSAASSTVVSSSSSYSSHMQSPTHDDPSSSRRRRSSIEKRAKAKAKGRDKATATDVTEQTPSFSTAKRLGYHRPYSLTELCDSSPFAWLGKSDMFAPPAPISRSLVKPVSPALVPFSSRPPAVVDPQPPQQTRHHRHHTTAHGGNAKNPEGRVHRIASEPLGVPSGPSGAPGSASEHDVEKGHQSKRTAKAVEYTVATTDNDCGHLARGVLPTADVHGDKPGDVVPVKGRGRDTRGKTLGASESTEDRAAAQEHAEMDKEKMRALEALTQLSIRDGGEADFARHIAADRARDKTLKEKQRAHHKFGGKTIEEEYDPSESEITMVEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3C3</accession>
    <name>A0A4Q9Q3C3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_919869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3C3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF147">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE OF THE SEVEN BETA-STRAND FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="43670" checksum="5AC3217184C044DE" modified="2019-07-31" version="1">MTLSLIAPPSSKLPSVRSIHERPLEVLASLVEYLRTIYNPPVRGTRRIDRKALKRSSTLCTGDDGKAALEALRADEFERAYAVRWLNGLVCQASLLSDPLEDSAVSGDSYNVEDKVDTLIHSATALIAVCAGSAALRTLTRQYAFYAPSLEADVDISLTDLSISVDADSATVGTQTWGSACLMAEMLVEEPGKFGLTDEVLSRAEGVRVLELGAGTGLVSLAAAKYLSMRGVKATVVASDYHPAVLSNLAHNIAANFPPPSPASADVSLCAHALDWSKFSLPGTAHHHTAEPPFDTPFDVILGADIIYELTHALWIRDTVAALLPPSRSAPAHAPAPRFHLIIPLRPTHTSESHMVEEVFLPASIGSARPSSELALCVLEKETILCEVEDARRSEVEYVRYVIGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3E6</accession>
    <name>A0A4Q9Q3E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_974763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3E6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18425" checksum="01490D8D53F3BA57" modified="2019-07-31" version="1">MTLSPVAPPSSKLPSVRSIHEHPLEVLASLVEYLRTMYNPHVRGTRCVDCKAFKRSSVSCNGDDRKAALTNPSGRMTCAGSMGSSSTLIYSPTHSKTALTVDVENKVDILIHSATALIAVCAGSAAVGTLTRKYALYAPSLEVDVDISLTDLFISVDADSATVGRRRDSVRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q466</accession>
    <name>A0A4Q9Q466_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mannosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_844492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q466"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q466"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF2">
        <property type="entry name" value="ALPHA-1,2-MANNOSYLTRANSFERASE ALG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="497"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU62092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="697" mass="79219" checksum="F51EE8D1E261EE26" modified="2019-07-31" version="1">MSTGVQLGPNVQTISFRKPTNQAASSPSTKPKNRHGGLLQDQLRRAQRAPWCPTWSSALRILLLIRVAGAMYNGIQDCDEVYNFWEPLHYLWKGYGFQTWETSPEYSIRSWAYILLHYLPVQLSAMFLGPEKRPAFFAVRIFLAIVSSLCEVTFYRAVVEHINYRVGRYVFFMLLANAGMWIASTSFLPSSFAMYANTLGFAHAMERPSNSNMRRTLFATLCFATGAIVGWPFSLAVAIPFVLEELFLTGADKVTSETRTSWLTTRWQRMVTCGAIAALLFVPVVAIDTLFYNKLSVVPWNIVKYNVFPDVQRGPELYGTEPVHFYLANLLLNFNVLVPFALAALPALLVTYRFDHKRLGERYLFVNQTSPYVLLAVRLAPVYLWVATMTAQKHKEERFMYPIYPLICFNAAVTIYLVRGWLEAAFIAATNSPYRASRSSLFSQFTLSVVVTSSVLSLARTMAHWKYYHAPLSVTYALEAAEVPRLLNATGHVSLPPQLDPAARHGGQEHPEAESDSEEQPRIDLSLVEPFNLRLCVGKEWHRFPGHFIVPDGVRVDWVKSAFDGMLPGHFSETPRKGGLLVRQQGTRVVPNDLNDLNKEARAFYVHVDSCDYLLDLDFPQHPQEGPHEPRYIVDEQTWARVACQPFLDAAHSPLLTRTLWFPGALWQQQNSYGEFCLLRHRANVAKKEREHTVHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4A8</accession>
    <name>A0A4Q9Q4A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_143965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4A8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="175" mass="20705" checksum="90F7A7DD261792C5" modified="2019-07-31" version="1">MNMQIERELTKPILQPHTFVHTDKHRDQLDPRSSMWLSRMPVTWFNSFIRSPEYWFLASFSTFSLRTIKLCTWIRPRALWKRSSSVGLCSHLRPGDPSDPTGATIPRASIWTMRLLIALWRSWLLAVGQRTWRWDRGGRRRSDQWNGGGPRRMEFSVFCTYETPACICRRYIGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4C0</accession>
    <name>A0A4Q9Q4C0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Wax ester synthase-like acyl-CoA acyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_196918</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a long chain fatty alcohol + a fatty acyl-CoA = a long-chain alcohol wax ester + CoA</text>
            <dbReference type="Rhea" id="RHEA:38443"/>
            <dbReference type="ChEBI" id="CHEBI:17135"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:77636"/>
            <dbReference type="ChEBI" id="CHEBI:235323"/>
            <dbReference type="EC" id="2.3.1.75"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the long-chain O-acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4C0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4C0"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047196">
        <property type="term" value="F:long-chain-alcohol O-fatty-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004255">
        <property type="entry name" value="O-acyltransferase_WSD1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03007">
        <property type="entry name" value="WS_DGAT_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1-like N-terminal" evidence="9">
        <location>
            <begin position="101"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="10">
        <location>
            <begin position="510"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="619" mass="69534" checksum="C3BDDF7C3C4D98E2" modified="2019-07-31" version="1">MVLQRRILNGHVHVASPGTPASYYYDDGDVQPPAPEDVDAKLNRVGSVGEVADRVADFIAQEATERRQMIGGVDNFWLLLSDITDFNPACTSVCILRDYVTVEKVAQQFTRQSERFPRFRQKLESVGRLFHGPTFVDDPDFNVLNHIQVRRLPEPAGKRELDALVGEFIAEDWDLSKPLWHTLIVENYHGDDGACAIVAKGHHTLSDGQGFVMSQLYLTSFFDDLAQMMNRASDKLDRAKRGLLLPSEYSKSFKPLDPYASDERVAPFLQFLLGLLFWLIVVAKNIFSLFWSTFQGLRMIAFFLFTFWRVEMITADQPGKRTPHREFSSTRIFSLQDVKVCQQAFSGPRPGYAVAGVPKDQRRNVRSKKRHVTLNDVVCAVMADVLGDIIASKPEPRTAWGKVRRTVNKYLPSPMGFFIPISVRKPGDWSMRNLSTASNVYLNPSPNLTSDISVHEIHAHIHRCRYELSLFKHSAWPKFCFRLLQLTGQAPILFPLSWFSRSRAHWNPLVKVLRNGVVKPFLDVCLESFTAILTNVPGPSKGPITWSGVEVVKWSAIPPQAGAGTIGIGIMSYAGGLSVAVSADLVPGSDGVARRICEGFEKRFELYVARAKEVLDHQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q526</accession>
    <name>A0A4Q9Q526_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_871280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q526"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q526"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="165" mass="18860" checksum="2DA9C541324CAAFB" modified="2019-07-31" version="1">MQLVDNETFLTQVSTLFESSAKSGSIWLTHKRLLYEGGDAHISSEGDNIKEYPCLVRVSDGDNSKFSTIVKPADLERFHAAYGTLLKASMSTLRKRDKKREKQRQEDAARKKRRLQEEIAIEGPKRGAGRRRRQRKMKQAAKLEESKKRAQEREEAKAKARAKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q529</accession>
    <name>A0A4Q9Q529_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_177891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q529"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10178" checksum="FEEC415DE940D89C" modified="2019-07-31" version="1">MPHEENHSCAPQLKGSDGSHAESASLSLGSVEPSAGTGIDSKSARTAAELPLQDVQPTKLRRVASGASIISLRGCHSLKVCLVDRLVFTCHRFPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5A4</accession>
    <name>A0A4Q9Q5A4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_52107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5A4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20664" checksum="3E877B93349E8DB2" modified="2019-07-31" version="1">MESNRGVGRHTAYHSGSDITGSEPNSATSLIHIREGTVNPETLSRSSTVDSFLSQSRRATTSWSSDELPARNMPLRPLRRQQSVERGPTVQYSPEEDETVQAAVEGEHATLLRPFPPTVSSANATASGEASSAASEAHPPSVENQELREQMARLQDEIERLRRIQEMQAILEDAPPMYDPSSAPRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5H1</accession>
    <name>A0A4Q9Q5H1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Natural resistance-associated macrophage protein</fullName>
        </submittedName>
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        <name evidence="7" type="ORF">BD310DRAFT_974316</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="TBU62539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="114155.A0A4Q9Q5H1"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
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        <property type="entry name" value="nramp"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
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    </dbReference>
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        <location>
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            <end position="102"/>
        </location>
    </feature>
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            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
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        <location>
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        </location>
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            <end position="450"/>
        </location>
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        </location>
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        <location>
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        </location>
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        </location>
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        <location>
            <begin position="497"/>
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        </location>
    </feature>
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        <location>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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    </evidence>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="TBU62539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="574" mass="61456" checksum="3F35B78EEA996B77" modified="2019-07-31" version="1">MLPPAPSRSSTSSELAMKTTSSQARSRWTFPSVSTALRAVGTHLLKHTGVGIVCAVAYFDPGNWGVDLQAGSQFGYKLLFVVLLAGLFAVYMQVLASRLGCVTGLDLASHCRLLLHDRPRHTLLWRWCVLYPLYALSEIAIISTDLAELLGSAMALVMLFPKLEIWAGVLITTADVLLLLAMRNPIGGQPVRAFELGIAALVFIVLICMAVIISKTQINWSDAFDGFLPSKTVFRSDGLYTSIGIIGATVMPHSLFLGSALATQDRVHSSPAENSTLGIETSVSVRNARTMAKNFVKALRSTFQVKRIEERPDEPKSHADWTNHPLSFIRQHLSHGIVDMVISLLGLAVVINALILILASAVFFVNGGGSTGPADLFDAYDLIRDRLGVAAATLFALALLASGQSSSIVATLAAQIVSEGFIHWTTSPVLTRLLTRCFGLIPSLVVAVAVGRPGIATLLVASQVVLSIVLPFVTLPLILLTSSKRVMTVYDNAECTSTSSTSSEELSEDTHKESKTEDVVVETITETVQDLERGSAKGVDFSNGKITVAIGAVIWIIIVAANVYAIVGLAMGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5H4</accession>
    <name>A0A4Q9Q5H4_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_919774</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="TBU62186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8972" checksum="2F5F21BFFE5BF94E" modified="2019-07-31" version="1">MVALALKGGRFLLSLVSDLYCQLQAIATIHQTEIGCVRFQSRHQTGSTCHLWETSVRSRFTTLSRSHRRTSIARWVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5W8</accession>
    <name>A0A4Q9Q5W8_9APHY</name>
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        <recommendedName>
            <fullName evidence="6">Pre-mRNA polyadenylation factor Fip1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_871320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <text evidence="2">Belongs to the FIP1 family.</text>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR36884">
        <property type="entry name" value="FIP1[III]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36884:SF4">
        <property type="entry name" value="FIP1[III]-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
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            <begin position="1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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            <end position="177"/>
        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="556" mass="58332" checksum="39E1999B33B2F1E5" modified="2019-07-31" version="1">MDDDDTYLYGDSHVDEPAKPALQTSVPQPISVEQTRSATEGLVAKLEEQAAEEVNGDGEAEPAENGGEEDADEDDSEDDIEIIMEEPQARSLDFRHQRQAGTRSTSATFTTPQRPPPQPQPSLTTEYTPRERAGVTKLPSTPQPSQTTQTPLPAVAATLGTTEKIAEGEKEEAKDTGPDPNTLPPVTAPPSHPSINPSAPGTFDGRSILEVDLNALAEKPWRRPGSDISDWFNYGFDELSWEAYCYRRRELGDIAGMLKSNVMNFAGMSEDQLIGLPPEVRTMVMAGATAVMAGAGGGGPGGGGMMPGAGMNMNGGPMMNQMMNMGPMMNQMMEMGMGDMGMVPDGGGGPQAGAQGNPEGQVGMGMGVGEGFGPGGGPSGQGMMGMGMNPEFGMQDPTAMGQQMYPGMDGSGTPTPVAPTPTRGIAQGQFRGRGMPQGMRGRGAVFAGRGRGIPVRPASPLPPNVPTGPRNKTKYKDIDGSAPAVDGLDYGGGGGGAAAGAAGGGDRERSERSERSERSDRKDRGTPDVDERDRSSRKRRGSPGEREESSRSSKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6E3</accession>
    <name>A0A4Q9Q6E3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/calcium exchanger protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_917695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU63047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6E3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6E3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043635614" evidence="9">
        <location>
            <begin position="28"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="634"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="697"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="740"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="773"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="111"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="643"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="286"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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    </feature>
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        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="797" mass="86221" checksum="730701CCEFE082C3" modified="2019-07-31" version="1">MWSGTPKLAFVALIVLNCLLWSQSRYAHVGGTRSALASGFAKRGFSDVDQLSPFRVTASEACQPLSVPPEEQCTHVKEVCDMDRTFLDIGYLESYFCADTAARPPLFVGYAVWLLFLFSTLGISASDFFCPNLGTIAHLLGLDENVAGVTFLAFGNGSPDMFATFSAMRSNSGGLAIGELLGAAAFITSCVVGSMCIIKPFKVSRGPFLRDVGFFTVAVSLLLIVLWDNKLEAWEAAAMIVLYAVYVTAVVIGSWWRRREEKRRRLEALMRAEYADEEHYHDEEPYIDEPSFSQSPSTQNLQVPSPYSRARSISHPDPPRLGVQTDLPQRPRTRSVSPSSPPLNHMPSFSLVGALEFRRVVSSLQRDAASASLSPFESPLTPYSYRRSRHSLRSGSRTPLRSPSGHGEQHNPWDAALGVPLDERPAPPAPQLTIGESSLEGGQHTRIPSISHTPASPTSVSDTDAESQTCVEVPRTRRQRVYKALAHVGHILFPTLHDFWSKSSLGKIAAILAAPAVMALTLTLPVVVTAHESPESSEKRRHSAAGSSVSPLIDFEEEGVERTLIAEDEVEEEMHELKFNKWLMAVQCCLGPLFCAAVLLDGMKHEGWLLLATGVTGLTAAILVAVFADKGLSPAAQLARCAMGFVVAVVWIMAIADEVVKVLQTFGFIFGLSDAIIGITIFAIGNSLADLVANMSVAVFAPIMGFSACFGGPMLNILLGVGISGSYIVRQTGVPYPLHFSPSLVITGTGLLAFLLATLVFVPMNGYLLPRTWGVSLICAYLVLMAANIVVEVMGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6P2</accession>
    <name>A0A4Q9Q6P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_668268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6P2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5975" checksum="9779FD421A0DCA7C" modified="2019-07-31" version="1">MHACSTASLIPPHPPAHLQTYSRDLIMRQKGLYATRWRHETDTGRRYAGLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8M9</accession>
    <name>A0A4Q9Q8M9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_945106</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q8M9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
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        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
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        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020539621" description="DUF1793-domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="670"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="5">
        <location>
            <begin position="102"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="5">
        <location>
            <begin position="227"/>
            <end position="290"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="631"/>
        </location>
    </feature>
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        <location>
            <begin position="639"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="75429" checksum="9D7C60EE8200BDBC" modified="2019-07-31" version="1">MLFLFLATICVNMFFEAGAVSWTSTPFSPPSVPLAVRSPYLSVWLPQGAGSALNDQWPQSWTGQDIIGWAGFAKVDGTAYVWMGSPGVPNVTFTKATQKSLQSNFVLTAGPVDLNITFLSPVEPSDLVNQSLPLSYYSISATSNDGKSHNVQIYVDISGEWVGGTRDGVTNQMQYASDIDHISQGSAYHSTLSVTGTTYQTGQDVVVRAQFVNNGILNNTLDTDFPPVVYSVGHARDPAIQYIVINNGRQEQSSYFWSRFSAMTDAIETFLKDYDDALIRADEYDKQINDAASKISSDYASLVALSIRQTFGTIEITAPRQSDGSLDTSKVLTFMKRSIKTVNTVDVIYPSWLLFLYSNTVIARSLIEPLLQYQSTGQYPNAWCVHDMGSNYPNATGHNDGLDTPLPIEESGAMLIMALSYTQWSSDLDLIKTYFDILEQWTQYLVANTLYPANQMSSDVFTGPLANQTNLAIKGIIGIQAMAEMAALTGDSARSANYSSIAATYVQQWRQLATSASGSHLILALLRTNIVPSDVYDMLAHPDCWYNGKADTYGLILDTRNTYTKPDWSIFTAGIVTSTDVRDQIVSAIVMFAADGQNNLPLADWYDVNTGRQEASSANFARPVVGAHLALVPAPNTTFPSSGSTGGPIGPSSSPASPKPRKSGSPATKGYGGVAVITFTLLAVLCTTICLADTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8U7</accession>
    <name>A0A4Q9Q8U7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CsbD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_916136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8U7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="20036" checksum="9B886A771ECCB3CA" modified="2019-07-31" version="1">MSRAQQDFQGTSNNYTQADQTWQNQPPNKMPADWNAQNAQGAQAFQPASMRPGDDLNSDQYGQTANQYPPTGLSAAPGHGGQLGASGQQLRDPASTTGAGITNTPGGGPFGHGHQHQHQQFDHDVPGQHARTSGSGGAGAAGPPSSVQAQATKPSASERIIGNTEKLAGKVSGSAGLVQRGEARKTGGGLNQENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q948</accession>
    <name>A0A4Q9Q948_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_945124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q948"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q948"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF342">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="60328" checksum="FC38EE261168A1EA" modified="2019-07-31" version="1">MILDTLSVPYEILEANNRIGGRIYTYRFNGEAGRNAPIDDPARYDYVDIGAMRFPNIPFMKRVFDLFEKLGMTEENRMLVPYQYSAASTFELFNGFRHSSADSAPEDFDIFGVSETKGGAVPDAFVAQGADTVAAEVFLPYRDAFEKLPFPEAWKLLTAEDPYSTRGYLLAKKDYPETVVEWLETFESATGLYNNAFVESTMDAMDFGSSSATTDAGIRGKDLDYPWYCIDGGADHLTTRMVNRIDTKPITGTRVTKIERTESGEMKVVYRTHGKYLMTYSQVICTVPLGCLAAIDIPKDDLSYMQRLAIRSLNYDTSTKIALKFESRWWEDPKVMGEGRTIKGGISSTDIPIRTCVYPSYGFHATGKVPGVMLASYTWAQDAQRLGGLAQGKGTEADGLLVELTLNNLSHLHGVPREKFGKLVDHYAYNWHNDENARGAFALFGPGQFGQPTRNNSMFASMKAPAADGKLHVAGEATSVHHAWVLGALNSAWRAVYNALGQLDPEEAVKKRKLLVDRWGIPDEETTKMLDHLAVLAQYKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9C6</accession>
    <name>A0A4Q9Q9C6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_808098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9C6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9C6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="287" mass="32326" checksum="0007AF44044462A7" modified="2019-07-31" version="1">MAETYAQEVSSAQFPMVGPGDTCPDAGTPLPIDHGKQVDRDAAEQGKNTSRERWKRAGFLASRLQDGNAMLPQPRGQGAHVEATRKHLETQHWLELTDGKHRYGSNWLNYLVTIDNNGKFRWARNGQLVDTTAGQWKDAGDGKGIVPFSYRTEGESTRPRHSFNVPASSTRSDSGASLSGDEVNAMMHYVGLQKQSKNPVKRLLLRNFTLRGLVDKLLRKTIKRNTWIYVSDKNFNIFIGIKGRSDTYTFTVVRTLSHFRKFLSVLEERDVDMSKVEISKAELALWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9E8</accession>
    <name>A0A4Q9Q9E8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_917091</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9E8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9E8"/>
    <dbReference type="OMA" id="YVRWLHG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF1">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="116"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="537" mass="59614" checksum="867795F5555EC09B" modified="2019-07-31" version="1">MEYTEKQPKAIDLAHHLSDVSRARETSPLKDLARQFGRPGLISLAGGMPNEAYFPFASISGDILHPASFSTSNDDNEESISWFWKLFGGSRKEKTSPITIPKHPAKPDDINLTVALQYGTATGLPQLQKFISEFVEKVYQPAYADWTALVQTGNTDGWSRCLSLLCNPGEAFITEDWTYPSALAGSVPSGKLPVGVPMDDQGMRHDELRKVLEEWDEAARGAKRPHVMYTVPIGQNPTGVTMGLERKKAIYDICVEFDIIIVEDDPYYFLQMGKYAAQSARAPHAGFADPAGWLTSLAPSYVKIDYQGRVIRLDTFSKTIAPGSRLGFFTCNPVFAERLERIGETSTQAPCGFGQSLITQLLTTWQFDGYARWLQGLAAQYTSRRNSFIDALQSEFHLRVSVGTAGSWKDCVIYTASAKARRGDAMSEKAALFGQGKPLFSFVPPSAGMFLWLKFHWDNVPGFKEGDEDTLEMKLWKKLAKAGVLVVPGRFFASDEDEVSPVEGHFRISFSYASNEAFKKSAKILSEVVGDFFHHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB47</accession>
    <name>A0A4Q9QB47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB47"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="298" mass="32358" checksum="4D59F52793134D8A" modified="2019-07-31" version="1">MAAAAAIVAPTVPPAGEPVEVLATHSPYALPTSAAQSVPEDRRGVMAVIFGGFGRTKTKFFDKTKPARDWISTKTCKAAGYAVVYGVPALQLAGEVVGDVVEAAGIPEDPIQYNPIKTATPWFLKMFAGMSPDYHLARGNKYLDDALDLLVNYEEFIPPNLMTDLVKNWLTLDNEGGGFHIVNQVPHVADARQWKRDAKYLMVLTKRKSREARARCLMAKEQPRGRNKASSTPQSAPLSSALRARSNRRRRGGAEDDRILEGVEPTPESDQESAQGDDPFTDASSDEGDAEDADDASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB70</accession>
    <name>A0A4Q9QB70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="9">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Lipoate synthase</fullName>
            <shortName evidence="9">LS</shortName>
            <shortName evidence="9">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_943882</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="9"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB70"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB70"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="122"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="390" mass="43174" checksum="00A0036BCBEF15F7" modified="2019-07-31" version="1">MRLCGPHVSNALRSTRAVKPQIRCLATPSSSKNSFSQTLEEGPSLDDFIADRVSDRVVLGNAKLCVPWPRLPSYLKTSIPKGASFSKIKKDLRGLNLHTVCEEARCPNIGDCWGGKEGATEAEGRRAATATIMLMGDTCTRGCRFCSVKTSRTPPPLDPHEPENTAEAISRWGLGYIVLTSVDRDDLADGGAYHFAETIMKIKQKAPQILVEALTGDFAGNLDHVSVVAKSGLDVYAHNIETVEALTPFVRDRRATFKQSLNVLKRAKEEGVRVTKTSIMLGVGENEEQVVDALRELRKVDVDVVTFGQYMRPTKRHMKVDRYVEPAEFDRWKQVAEDMGFLYVASGPLVRSSYKAGEFFIENVLKGKGTEKRTKNLIADKVLESEKLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBU7</accession>
    <name>A0A4Q9QBU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_913291</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBU7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBU7"/>
    <dbReference type="OMA" id="PNYREYM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="246" mass="27705" checksum="0A0F65C3D1E8EA06" modified="2019-07-31" version="1">MKLTPELIQSVPSTLNPVKERQLDLRGYTIPAIENLGITRDQHDCIDFTDNSIIVLGNIPLLRRLRTLLLANNRISSISQSLHLSVPNLTTLVLTNNNIAELGDLEPLKDVKSLQYLSLLGNPVREKKWYREWLAWRIPSLRVLDFQRIRDKERQAAKALFLTADNLPTQLATTISQTVTTHSSKPPITTDEPKPALQGKAGRLMSKEEADKVREAIARATSVEEIRRLERMLKEGFLPGMESVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE98</accession>
    <name>A0A4Q9QE98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_943056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE98"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13773" checksum="BF9CA4946620371B" modified="2019-07-31" version="1">MVEMLAMLQEMQKRKATKSSARSIAFQKERDALYTTARKKAEASLRDGMASLDKARALVSDLRAKEVTQEATLNQFRVILAEQNACVQTLLGHHTEVIEDLSHRRAAQINEASAMCVTLTAVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEB6</accession>
    <name>A0A4Q9QEB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiquitin-conjugating enzyme/RWD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_912685</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEB6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEB6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU66065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="309" mass="33395" checksum="A61143769D57DBE3" modified="2019-07-31" version="1">MAARTGLNKNNSAVKRIMQEARELANDPCTDYAAAPLEDDIFEWHCTIRGPPGTEFEGGLYHFRILLPSEYPFRPPAIMMLTPNGRFELNTKICISFTNYHEELWQPAWGVRTAIIGLQGFFPLKGTAAVGVGAIEYPTAERKRLAALSREWVCPRCNMSNLEHLPDPPASDGSASSSSSSSGDNSSSTPSPAPVSSSDIPIVAVQSPNAQPVLAVETQAPMPEAHIVHRPVPLVAPKPTRPHAQPSIVTQSFTPPGTPFTQPATRDATPQPALVAAVRQTPKRPPVLLDTAICVLLSLMLALVARRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEG0</accession>
    <name>A0A4Q9QEG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_804477</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEG0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="2">
        <location>
            <begin position="152"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU66232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="221" mass="23606" checksum="A75BEF53F5E10280" modified="2019-07-31" version="1" fragment="single">MALIRALPVEYTSLRHTLLLDDSLTLDKLQDIFVSLENQPGASPPVPALSNAATSLSCTFCSRSGHSEDQCYAKRDASVKAKEQRAAQRSQYRSNKSRNKQEASQASNDTSRTQGTPQESAGAATVSAGCALALSSSADRSTWLASPAAANWNTDTGASAHMTPHRHWFRSYSPHNVPIRFANSHIVYSAGLGSVVFQPASRGGVLPPAVVLHDVLHVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QGD7</accession>
    <name>A0A4Q9QGD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extradiol ring-cleavage dioxygenase class III enzyme subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_963638</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QGD7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07363">
        <property type="entry name" value="45_DOPA_Dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.830.10">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014436">
        <property type="entry name" value="Extradiol_dOase_DODA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004183">
        <property type="entry name" value="Xdiol_dOase_suB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30096:SF0">
        <property type="entry name" value="4,5-DOPA DIOXYGENASE EXTRADIOL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02900">
        <property type="entry name" value="LigB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Doxgns_DODA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53213">
        <property type="entry name" value="LigB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Extradiol ring-cleavage dioxygenase class III enzyme subunit B" evidence="6">
        <location>
            <begin position="65"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="322" mass="34989" checksum="FBDE9F52BF27FE63" modified="2019-07-31" version="1">MSTTNGTSVSLPRTQEDWKKALDELPSTPDKIPAFFFGHGSPMLAFDVADAGTMGEVGRAMGPKGNLATFLKDFGPALLSKYKPKGIVVFSAHWDTAGERLVTDYGDENPLLYDYYGFKPALYQLKFKSRGDSALSQRVVQLYKDAGYLARTTSKLEPRGRDGRGFNGPGLDHGVFVPFRLMFGEEFTDIPIVEVSMDSSLDPQANWQIGEVVEPLRREGILVLSGGLLIHNLRDFSAFSETTANSAVKDFNQAILDAVTVKDPVARKEAMLNLVKHRGFRQAHPTADHFVPLYIGAGAGGGNADAKVLAAIYGAPTIAFDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K352</accession>
    <name>A0A4V2K352_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_937789</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145211">
        <property type="protein sequence ID" value="TBU53543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K352"/>
    <dbReference type="STRING" id="114155.A0A4V2K352"/>
    <dbReference type="OMA" id="FIVCYHI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="221"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="516" mass="55091" checksum="CB154842F4B28562" modified="2019-07-31" version="1">MPSAAFLVYSGIMPLLKTFFTIIAGYAAAKMGMFPPAASRGTSHITMNMALPALIFANVVPAFTPSNISALGPLFLIAFTYQAIGFLSGLIIREVCYVPRNFWQGVIVMTGMSNWGNLPTAVVLSITQQAPFNPATDPALGVSYVSIFIVSYHLVFWMGGAAHSLSWDFRPGVPQGEAAEVRVSWKEKPIGSLITRYILRQEPPNSFAAAAIEADKTKDIEESFSEKEKNAGTDGAIPVSELRRSEGIDDTAESDPDVQLARRTSRISTASVPMPHRRPSLSAAAAPSAIPSAPPPSPAQSARDLETQSIAQRSETLHTPTLPQKIVRVFRPLGAIVTPVTCTLAVSLPIALVQPLKALFVDVSATGGPSFKGPDGRPPLAFMIDTANFMGGITVPLALVLLGASFARIKLPRPLSRLPIMAMFLSTFAKMIMLPVIGIFLVQAMTGAGLVQKDEKALRFVMMFLSGTPTAVNQLIVASLYAPDGNVDNLSACLLVQYIFMFIASSALTAVALLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5V3</accession>
    <name>A0A4V2K5V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Erg28-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_917758</name>
        <name evidence="14" type="ORF">BD311DRAFT_750150</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERG28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5V3"/>
    <dbReference type="STRING" id="114155.A0A4V2K5V3"/>
    <dbReference type="OrthoDB" id="6485510at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005352">
        <property type="entry name" value="Erg28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451:SF19">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15451">
        <property type="entry name" value="ERGOSTEROL BIOSYNTHETIC PROTEIN 28-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03694">
        <property type="entry name" value="Erg28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU32500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU63076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15752" checksum="D6A0A4AA5D541AD0" modified="2019-07-31" version="1">MPIFDAVSGYLPQGPGWLPTWQLIVAVTAALNTVSNLTSLTFSRRLYNNAVTSVNPLQARTFAIWTLTSAVVRFYAAYNIHNKLIYDIALFTYLFAFFHFGSEILIYRTAKIAAPVLSPVIVSTSSLIWMLTQYNFYVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5Y8</accession>
    <name>A0A4V2K5Y8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MTHFR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_911372</name>
        <name evidence="11" type="ORF">BD311DRAFT_679999</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5Y8"/>
    <dbReference type="STRING" id="114155.A0A4V2K5Y8"/>
    <dbReference type="OrthoDB" id="16284at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF1">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="10">
        <location>
            <begin position="340"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU35607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="604" mass="67262" checksum="E87DD1291BD7B0BD" modified="2019-07-31" version="1">MKLTDRIAQHDPNRLFYTFEFFPPKTDQGFENLVSRIARMVALNPLSVSVTWGAGGTTKDRSLDLAGLTQLEHGIDTTLHLTCTNMVQGTVDAALREAKERGIENILALRGDPPRGSEHWIPTDSRFQHGVDLVRYIKSTPEFAHFCVGVAAYPDGHPDRDTTEDRELDHLKEKVNAGAEFIITQLFYDVNGFLQWVKKVREKGITVPIIPGIMPIQTYASFLRMTKLCATSVPPKMMSDLVPIRHDDQKVKDYGVRLAVDMIRQLQAGGIQGVHFCTLNLEKSIIRILEALGLAGDVSHSSNKLIADDAVPPERTVTPHTAADRATKELATSVPEPDASKGEINSAADWDDFPNGRFGDFKSPAYGETDRWGSSALQSKAATTPVSHWGNPKTVNDLTSLFLRYLHSKITTTPFSSTPLSPESLMIFPHLEKLTSKGWWTVGSQPAINGAPSTDEVVGWGPRGGYVYQKCFVEFFVAEQDVNRIARKVDSEGAGWISYFAGTAKGDVLTNVPEGGRNAVTWGVFPGQEIAQTTIIEKESFLSWKDEAFSIWDEWASFYPPESQERRLLEDVRDKRWLVSLVHHDYMDPNALWTFLFKGATPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6M7</accession>
    <name>A0A4V2K6M7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MGMT family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_861235</name>
        <name evidence="4" type="ORF">BD311DRAFT_733709</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143565">
        <property type="protein sequence ID" value="TBU21955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6M7"/>
    <dbReference type="STRING" id="114155.A0A4V2K6M7"/>
    <dbReference type="OMA" id="DEAEWWF"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="3">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU21955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="138" mass="14972" checksum="AAB4DCE115B78995" modified="2019-07-31" version="1">MDGDWFHTAVYHVVRQIPPQRVTSYGHVAKLIGKPAYSRHVGQALKFLSPDAHPPVPWHRVVSSTGAISSRGPGTDGATRQRDALVAEGVDVVTTRSGELKIDLREYGWFPAPGTVDIGVERDEEEGSGGERDEQGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K771</accession>
    <name>A0A4V2K771_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_885243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K771"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="465" mass="51937" checksum="B75A50E27F472630" modified="2019-07-31" version="1">MRVKLLRLYTLGGWKSRTMSSVNPETQAMETRDKVGLLDSETTDPRIAHRSLINDMLPTEIFDEIFGILQDAGWSLSARTRVCKLWRYLSYRRLFSAVMVRGESKQFAHFCATHPQLASCIQELRCHRFSVPTQRSLTDFIALISILPSLTNLHTLHITGSLHREPWTLAIARRPPIQLKKLVLHLCAGISSVLSFLLTAFDVHCLELVNLQDPKPVSLVGLYRQTFELSQLIINDNVRSSGVWYGLLERVLNPGTLRALAVGCSTTDDLRELCTFLSSTPAPNLHNISVDVNPFKLWDLQGQTFAGLGSVLAKCRALEHLSVGIKDNGGVRTSRTAFFSPILAPISAQRSPPPLRAIGIRVWTRMPVEFLALDDPRSPARSLDFDSLDKLLSAPAGNFARLESVTLEIVADNSAWGMQPEVTLHKGMLRRIREAGLLRFVYSPKADWYSENAEIFVPHSPHGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7K6</accession>
    <name>A0A4V2K7K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_950065</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7K6"/>
    <dbReference type="STRING" id="114155.A0A4V2K7K6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="60926" checksum="A4F05C39C4437C69" modified="2019-07-31" version="1">MHTTLLAAAFLAVLAYASWKYFLSDLILPSPLDDLPAPPSLSFIKGNVADITSRQSWRYWRQHAKTYGPVSVLHGLLGTKILVVFDPRALHSILLKDAENFPQRLSPSDDLNMLLGPGLLTSEGSQHRRQRKLLNPVFSAAHLRHMTDMFYEISHKLCAAIGDRVAKEAAVVDMNGWMARVTLEILGQAGFGYSFDNFMEDSTDAYGDSIKNFFPVFSRLPLLPIVLPWMTYLAPDHLIKDILRLLPHAGLRRMMDISDTMERRSKEIIAEKKAALTKGDQTVVDQVGERKDIMSILLKANMIALHQDKLTDTELCAQMSTFILAGMDTTSNALTRTLQVLAQHPEAQKKLRAEILEAHNGEMRMDYDALCKLPYLDAVIRETLRLYAPVALLPRRPTKDAVLPLSAPIRGKDGALLREVLVPKGTRIVVNLQASNVNEAYWGEDAYEWRPERWLEPLPEALEEARIPGIYSHLMSFMGGSRACIGFKFAQLEMKVVLSVLLMAFSFELTAKEIAWNSGPVSYPTMGWENMKPEMLLRVKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7V0</accession>
    <name>A0A4V2K7V0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_880731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7V0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26886" checksum="036083170FD1E53A" modified="2019-07-31" version="1">MTNTTLRTIALTCSQLCPRSLFVLYTKVVLRSTKQLVKFYDAVQAQPHLQPVVRSLSFPWNDFSPFPLLSILHGLRHVAFDRISSVIGDDVQLPLSTLVHDRRLATSIRSISIRNAIFPTQTTFLDFLSNFPSIENLTCEYVAIQSRLPIPLEKVDLMCGVKLRSLHILRYVSEDITELLVHMVQSVDTSTNANGEHTGLCIVLSPSRISHTTQRQIRSIIYASRTPPVLLNMVDTGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K901</accession>
    <name>A0A4V2K901_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="9">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">NAT10</name>
        <name evidence="16" type="ORF">BD310DRAFT_920238</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K901"/>
    <dbReference type="STRING" id="114155.A0A4V2K901"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 9 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="12">
        <location>
            <begin position="277"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="535"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="15">
        <location>
            <begin position="772"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="431"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="936"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1008"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="957"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="446"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1033"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1048"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="636"/>
            <end position="638"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="643"/>
            <end position="649"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="735"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU61958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1059" mass="118625" checksum="815E191EB5275D5A" modified="2019-07-31" version="1">MRKQLDPRIPILINNNVKKNHRSFIVLVGDKGRDQIVNLHFLLSQARVSARPSVLWCYKKELGFTTHRKKREAKIKREVKKGIREPNEQDPFEIFITVTDIRYTYYKESHKILGQTFGMCVLQDFEAITPNLLARTIETVEGGGLVVIMLKTMKSLRQLYTMTMDVHARYRTSAHDSVVARFNERFILSLGSCDDCLVLDDELNVLPISRGKDIKPIEEVRGKSKEESELKDLKDSLADTKPIGELVKLAKTIDQAQAILTFVDAIAEKTLSSTVTLTAGRGRGKSAALGLAIAAALAHGYSNIFVTSPSPENMKTLFEFIFKGMDVLGYEEHLDYDIAQSTNPDFNKAIVRVNVFRNHRQTIQYIQPQDAHVLGQAELVIIDEAAAIPLPLVRNLIGPYLVFMASTINGYEGTGRSLSLKLIQQLRESTRPSLTKDSAAADDDAASAPSSSKKPLTKAPPKARTLREIKLETPIRYAAGDKVEKWLNSLLCLDATILPRQTHMSCPHPSKCELFYVSRDTLFSYHPASEVFLQRMMALYVASHYKNQPNDLQLLSDAPAHHLFVLLPPLKDDETHLPEPLVVLQVALEGNISRQTIMENLSRGFRAGGDMIPWLISQQFQENKFALLSGARIVRIATHPDYANMGYGARALQALNAYYSGQYFNVDEAIDAEQSYPDPATFDEDTTLLTDEPKVRAATAMPPLLQRLTERKPETLDYLGVSYGLTPPLLRFWKRAGYVPLYLRQTQSELTGEHTCVMVRGLNSSTEDELQWLSEFAKDFRRRFLNLLSYKFREFGSVTALSVLEAVNAGVKKLDEDPARELGSTELSFLLSPFDLKRLDSYANNQLDYHVIMDLLPTVGQFYFEKRLGPDVRLSAVQSSILLALGMQRKTIEEIEAELNLPVSQALALFVKVVKKISKRLLDVQKAAISATIPDRREDEVKRTDAEGNKAEFRPLETTLEEELEEAGDEAARALREKQRAMLDALDLSKYAINDASADWSAAEAQVAKLASGGQGKSTLVSVKTSAVVGQKRKAEDKGKEDKSGEKKARRSMKKSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9V4</accession>
    <name>A0A4V2K9V4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_911013</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9V4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7848" checksum="798390FE596D84DC" modified="2019-07-31" version="1" fragment="single">TARYQPHFSCPLFSKGSVVSQTSQKSMNREYVKDESFPRRLTLPLRHFVRGEECHRRSRGFEGEFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MS21</accession>
    <name>A0A4Q9MS21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_820635</name>
        <name evidence="2" type="ORF">BD311DRAFT_659180</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143406">
        <property type="protein sequence ID" value="TBU30395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MS21"/>
    <dbReference type="STRING" id="114155.A0A4Q9MS21"/>
    <dbReference type="OrthoDB" id="2593747at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="29"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="233" mass="26398" checksum="08E3C2E151075C2E" modified="2019-07-31" version="1">MGPRPQSTESTSSGSTNRTKRSKFYMQDGMVVLKVEGTLYRVHKYLLEQHSDFFRGLLSDEVDAMGHSDDRPIPLPDSITQQAFDSLLGFMYTGVFDPTSVSLSDWVSILRISTLLQFTKMRQYAIRELSARRASLVPVEAILLAKEHDIPSWLGPAYAELVRRSTPLDDTEAESLGVRVTAQISRAREMLRAEEYALHQQRRYGSRYTPPERPDEQLVARAVNEVFQLAGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MTQ9</accession>
    <name>A0A4Q9MTQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sds3-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_922752</name>
        <name evidence="7" type="ORF">BD311DRAFT_805420</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MTQ9"/>
    <dbReference type="OrthoDB" id="70376at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013907">
        <property type="entry name" value="Sds3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01401">
        <property type="entry name" value="Sds3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="166"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU60588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="35950" checksum="C804CB100C4D1A27" modified="2019-07-31" version="1">MPPQPGVFAVSHSSTHKVRSGQAVEVASVNTLHYEQIAGPSSRPHGAPGEDPKKDKRRKEVVGKITKEMAERREDIGRHYAETISDLHSLSIQLATRPETSPQYQLRLYPISLERGALLSSIELQERHALSVVQTAYDEERERVEEEWKRGRDRIRERMLEGIEDRRRRAREEKDGEGTVADGGVDSQSRPHITRKLRNKMGGGTSPPPTPIPGGHPGLGIGAGAGAATGPVTTGPLLNPHSLSVDELPSLFPLPLISGQVSGSQSYGYGTGAGGAGNGRRRAKGGGREAHAPGTLGKALGALSVLKEPECEADLGEIRRGNKRRRAAAGSLAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N6D3</accession>
    <name>A0A4Q9N6D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_433788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145425">
        <property type="protein sequence ID" value="TBU51055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N6D3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13612" checksum="B657E0E904F3EC24" modified="2019-07-31" version="1">MTDSCGYAVPIYTVMSRRSALLTWSDTGWTIGCKAVDDDVPGRAVWAHGRPTACLGTEGMCRFHSSWSDCRRIDTDRGWLPYHHLLSVISLAPKHILIVSDRRKRYSSGRIKQNSGRTSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NA32</accession>
    <name>A0A4Q9NA32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918243</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NA32"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6608" checksum="A71AC91368AAFE5B" modified="2019-07-31" version="1">MYNYTSIPLPTTYGWYYIFPTFYSLGSSPTIVVVHHRLSIICCVSRMSSALLLNRSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDT5</accession>
    <name>A0A4Q9NDT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_934925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDT5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU54817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="281" mass="30590" checksum="A1AD3FB0C8C89A08" modified="2019-07-31" version="1">MAIWFITGASTGFGRILAEIVLEKGDTAIATARRPELLSDLSAKYPAERLLILKLDVSKPQEIIDAFAAAKEKFGRIDVVANNAGQGTFGEVEAVADADVRAMFETNFWGAANVSREAVKFFREVNPAGEGGRLLQISSITGLRGHGALAYYSASKFALEGFSEGLANEIDPAWNIKITIVEPGGFDTPGLRKTTWAPAHVAYSNKELPGNVLRGIWEQYHPKGDARKGMEVVYKLAALEQPPLHFPLGKDAIGVVRSKTQSLLEDTEKYEPWNEGLERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGI1</accession>
    <name>A0A4Q9NGI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_953103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145288">
        <property type="protein sequence ID" value="TBU51752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGI1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16838" checksum="CB1C40E31AE1048A" modified="2019-07-31" version="1">MSHGLSSHSAPFPAIIHRRSWSIGMRIFLFFDTIGTAFTMSLGCTTYSLRSQGIYQGRYKDVFREVDGNFEILRILTLARHIQRTLASARAAGGHEERPGNRGAGQGEVGAMKSTTAAERGIRETQRRAGACSDRLEETSYVLARKGITRSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGZ4</accession>
    <name>A0A4Q9NGZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">RPS1</name>
        <name evidence="9" type="ORF">BD310DRAFT_906331</name>
        <name evidence="8" type="ORF">BD311DRAFT_737076</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGZ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NGZ4"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="modified residue" description="N-acetylalanine; partial" evidence="6">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU32146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="256" mass="29335" checksum="0E2E2AF3279218B6" modified="2019-07-31" version="1">MAVGKNKRLSKGKKGIKKKVVDPFSRKDWYDLKAPSIFEVKNVGKTLVNRSQGLKNANDSLKGRIIEVSLADLNKDEEQSFRKIKLRVDEVQGKNCLTNFHGMSFTSDKLRSLVRKWQTLIEAHVDVKTTDGYLLRLFAIGFTKRRPSQVRKTTYAQSSQIREIRKKMFEIITREATSVDLKELVQKFVPEAIGREIEKAARSIYPLQNVYVHKAKILKAPKFDVSKLLELHGESTDETGTRVVKDFKEPEILESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIE2</accession>
    <name>A0A4Q9NIE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Terpene cyclase/mutase family member</fullName>
            <ecNumber evidence="7">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_817172</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the terpene cyclase/mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="7"/>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIE2"/>
    <dbReference type="SMR" id="A0A4Q9NIE2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIE2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000250">
        <property type="term" value="F:lanosterol synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000003">
        <property type="entry name" value="Terpene cyclase/mutase family member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764:SF20">
        <property type="entry name" value="LANOSTEROL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="TERPENE CYCLASE/MUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Squalene cyclase N-terminal" evidence="9">
        <location>
            <begin position="82"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene cyclase C-terminal" evidence="8">
        <location>
            <begin position="383"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="726" mass="82396" checksum="495D926CF6FF889B" modified="2019-07-31" version="1">MAAFAPLDLPASGKLPFTDYSRWRLRISPNGDHTWHYLRTDDDLAAWPQATYDKYWLGQDVGLPALPKPTNALEAARNGYRFFQKLQCEDGHWAGEYGGPMFLIPGLVIGNYVCGQGFELEERLEMIRYLFNHANEDGGWGIHIEGPSTVFGTALNYCAARILGLKPDHPVAVKARACLHKLGGAVGAPSWGKFWLSILNVYDWEGNHPIPSELWLLPDWVPIHPHRWWIHTRNVYIPMGYLYGVRFKMEETELVLDLREELYQTPYRSIDWPAQRSNVAAIDLYTPHSTLLEGLYGLLGTYEACALAPVRRAAIARCHELVVLEDENTDCQDLGPVNKMMNQIVRVHAEGRDSAAAQRHFARCRDFMWICAEGMMMCGTNGSQLWDAGFAGQALVETGLGLEDEFRASVLGVLGWLDRCQIRENPRHWRTAYRHQTKGAWPFSTKTQGYTVSDCTGEGLKAVLYIQEHVKDAPKLVSERRLCDAVDVMLSLQNADGGFASYEVIRAPLWMEYLNPAEVFGNIMTEFNYPECTTSVITALAIFRKHYPHYRAADIARTIAKAVDYLHRAQRPEGGWFGSWGICFTYATQFALESLALVGETYASSAHARRACDFLVGKQRADGGWGESYKSCESLEWVEHKDTQVVQTCWAAMALMYAKYPHPEPIERAVKLVMSRQRPDGSWPQEAIEGVFNKNVAISYPNFKFEFTIWMLGRAHHYLEELRSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKX2</accession>
    <name>A0A4Q9NKX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_871012</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKX2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NKX2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="120"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU62808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="212" mass="23083" checksum="55A3DCD973BA0816" modified="2019-07-31" version="1">MLRNQLLQLAVPLVKQYGFTREALARSVLHLPAPHEQPLSEAAVTSLFGDGDDARRTLINGWLDIARAEMKASSSPTSSLRDVLANRLRANEPVLPLLPEAFALLASPSSGLPPLDPIPGLKHVSKIADDACYLTGDTSVGPAWFRRRAAVAAAYGAAELHQLTSPKTTYQFLDQVLNLTNKVDTSVSEVEQFGRYILRSWGGIIRSRGIFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMB5</accession>
    <name>A0A4Q9NMB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pinin/SDK/MemA protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_833329</name>
        <name evidence="10" type="ORF">BD311DRAFT_779569</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pinin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143444">
        <property type="protein sequence ID" value="TBU26533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145277">
        <property type="protein sequence ID" value="TBU51909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMB5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NMB5"/>
    <dbReference type="OMA" id="IYYLPYR"/>
    <dbReference type="OrthoDB" id="330772at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039853">
        <property type="entry name" value="Pinin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006786">
        <property type="entry name" value="Pinin_SDK_MemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707:SF0">
        <property type="entry name" value="PININ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12707">
        <property type="entry name" value="PINN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04696">
        <property type="entry name" value="Pinin_SDK_memA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Pinin/SDK/MemA protein" evidence="9">
        <location>
            <begin position="31"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="265"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU26533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU51909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="312" mass="35046" checksum="AF289AF4E4549EAB" modified="2019-07-31" version="1">MSAEAPAPASAEVDAKTAKKRPRLDMAVEPRERKRGKTAFGLLLGTLAKAKDEAKERNASEAARRRQQIEKKTLDKLRKETDSVRRAEEAKKDKTTANRKEEELQLKDSIHKLRRTRLPLLANFLLTSDVIPPVDSDSPASTNPLVGPPKARPPPLYYLPAKLLPSQTAFLQRRKAEVQEAAEKEWEQFKAERAAGVEEINRLRERVAEEESRRKTDRRDPTEKDGEGDAKMVDEGEEQEQENKPGREALHENGNGDASMAVDDGAEKEKESEEKERKEEDVAAGKDEKKDEKKSDVTPTPGPGYDDDAVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR91</accession>
    <name>A0A4Q9NR91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_808449</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR91"/>
    <dbReference type="OMA" id="QGDFMSH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU63510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="471" mass="53247" checksum="0144F005E66A7610" modified="2019-07-31" version="1">MPKSYPWVAYRDLCAQYGDIVHLRSFGKSTVVLGSAEVVQEYLGKRAANTSDRDRSPMIELTGQSASFAQMPYGEKWRRHKRAFWQCFYPEAIVDYQPIQRASAHRFLERVLDDPSRLVKLIRFGFASSILKVAYGIKAKDETDPFISIVEAGHEGVVDGLPSGRFLVEYLPFLRHVQPWIPFSRSPKLWAKWQAAGRRMTETPYVFTKAQLEQGNASQSIIAKLISRLSQSEEMSPQDEETTMNVGMVAFEDHQVYSTLQSVFLAMSLYPDVLRKAHAELDAVVGPHRLPEFGDRSSLVYINAIIREAMRWHVVLPLGVPHATTEDDELNGYFIPAGTLLLPATWYAQLHNPAVFEDPDQFRPERFIRDGKLDLTVRDPTTFIFGYGRRICPGRHFGEAALFINVASALHVFDITPPLGADGKPIKVEYSMTDGFNSYPEDMRCTVRPRSAAAEALIRSYASEARATMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NY22</accession>
    <name>A0A4Q9NY22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_975771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NY22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043467333" evidence="2">
        <location>
            <begin position="22"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="451" mass="47244" checksum="5BDDC6BF1E6A3AF9" modified="2019-07-31" version="1">MPSLNRLLVLAVLGVSLCVQAAPLPEGTSVDAIAAAKRDLVAADDLYERHVDDDDVEFLDADEVEDEDEDDLEERDFDDEEEFEGDEDDEEGTFLERRKAKAVKAPKIAAPKLPKVAAPKAPKVAAPKAAKPVKAPPPVKAPPPVKAPPPVKAPPPVKAPPAKTTKAAAKTTKAAAKTTKAAAKTTKAAAKTTKAAASKTTSTKSTSTAGAACSATAKPKTKKPFFARASDYVAHLFERDSQEFIGWHGTNSDTAAFWAQKGQLEKPVKADGLFDFIGLGPKSSSGTSGADAEIGPGVYVTDDQDIAIAFANNNAKVNPGTTAQLCAVFAKSSANWRTAIRKAFIPENLVGDSSNAAKKAQLENARLAHVKQAVPGVSAPSVVKFSLLNRITKTGQLVLPATITNQFTAQCFKADGGAAAPGTNKFPAFSYNGNTLRTEWNIAAENAGQCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NY77</accession>
    <name>A0A4Q9NY77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PINIT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_916066</name>
        <name evidence="12" type="ORF">BD311DRAFT_860859</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIAS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NY77"/>
    <dbReference type="STRING" id="114155.A0A4Q9NY77"/>
    <dbReference type="OMA" id="PTEQIWK"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.780">
        <property type="entry name" value="PINIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023321">
        <property type="entry name" value="PINIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038654">
        <property type="entry name" value="PINIT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14324">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51466">
        <property type="entry name" value="PINIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PINIT" evidence="11">
        <location>
            <begin position="143"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="SP-RING-type" evidence="10">
        <location>
            <begin position="342"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="136"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="622"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="682"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU35340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU63861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="699" mass="77529" checksum="DB0FD1D8E63E3776" modified="2019-07-31" version="1">MESQDVWSDFETLRHNVKHNKVDQLKQILSAFNEECYTNHTKTGKKQDLIDKIVRSLDEWRRENNRERWSRAKAIMNRVRTNSYHAGAYRPNGDSSSYSHSHSFAPPPPTTAYQSGSSLSGAIPRYDPYAPPRRPTQPASVTPTSTVPVPQQPMPVIRFKYSPFFRMERIVSAVVECPESTSSMDRRSQSLTFTMQPDIIAKLNSSSPKYQLRLYCTSSTYYTPNGSFRSPGATPCPIEFPPTCEVRVNGTQLNANLKGLKKKAGTAPPPDLGKLARQTANASNRVEMIYVNSQQPTPAKKFYLVVMLVEVTSVDQLIERLRKGKYKPKDDILAEMNKAASDDDDIIAGHQKMSLKCPLSYMRITTPCRSSACVHPQCFDAMSWFSVMEQTTTWMCPVCEKVLNVEDLIIDGYFDDILKHTPDSVEDVIVEADGQWHTEDNKFASPVWKATHPTAPPVKPPVPKRAASPVKHAANGMNGVNGQEKPRPSQAEIVILDSDDEDEDEGRVKRELSPSTDGVLPRPSQSIGGSQPSRSTTAQAADIIDLTLDSDDDEPPPPRLSAPSTKKRKETDELLSPTEQIWKKSRTESGSSSSSPGFDTLVNSSTLRMAEEAAAQRRLGAPSTSQPRYQPSSQRSPPYRGSQPFNPPERLPPPPPPPPTLPRRLPSSPHDGYRTTLPPLAYTSQRGSGAGSSSPTSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYK7</accession>
    <name>A0A4Q9NYK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYK7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47369:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="343" mass="37297" checksum="180C16FCA08BB4D6" modified="2019-07-31" version="1">MIMNGHGAPSNGTATPGPGDGYANGPSTSAGAPVNGYDQHPSLYQLHNEDIINHLFHSGFQTGNYADTLLHVRGTVYRLHALILSRSPYLAHLMSTSPQTNSQYVIYVNLEHEPEVTDEGFHHALAYLYSAAALASIRPENARAVLAAACLLGRMDDLCNYAYEVCRQSISLDTLPSWLEFVDSVPAPSDGSSTPIVEQHQHLRTAVFGSYAQRLRDDVFNFLIVTLPNLVNFGGQATPTTPLPESSSTPTDAGRDTLLQVFARVPFDLFKAAVESPTFQLGSTHSRFKFAKDAIELRKQSIARGQGAEETVVLAFGGSSTQSTGVLVTRKLRKRQLWKVNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZV3</accession>
    <name>A0A4Q9NZV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">squalene synthase</fullName>
            <ecNumber evidence="3">2.5.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_928794</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.21" evidence="3"/>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZV3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZV3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045338">
        <property type="term" value="P:farnesyl diphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000023">
        <property type="entry name" value="Squalene synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006449">
        <property type="entry name" value="Squal_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044844">
        <property type="entry name" value="Trans_IPPS_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01559">
        <property type="entry name" value="squal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626">
        <property type="entry name" value="FARNESYL-DIPHOSPHATE FARNESYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11626:SF2">
        <property type="entry name" value="SQUALENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="508" mass="58192" checksum="E67A0AC7996F99DF" modified="2019-07-31" version="1">MSRNTASSMLALLLTHPFEFRVLLQYKLWHEPKRDISQPSEHATSGWDRPTMRRCWHFLDLTSRSFSGVIKEVEGDLARVICLFYLVLRGLDTIEDDMTIPDEKKQPLLRQFHKLAVKPDWTFDQCGPNEKDRQLLVEWTVVSEELNRLDPRYREIILDVTEKMQYGMADYAHKAAATDELYIETVDEYNLYCHYVAGLVGEGLTRFWAASGKEAAWLGDQLELTNAMGLLLQKTNIIRDFREDAEERRFFWPREVWGAALYGKAVGRAGGFADITELYAPGNEKQALWVLSGMVVDVLGHATDALDYLRLLTKQSIFCFCAIPQTMAMATLSLCFMNYDMFQRHIKIRKAEAASLIMKSTNPRDVAYIFRDYARRIHARALPDDPSFLRLSVACGRIEQWCERHYPSFVRLQQVSGGVQYDPRDVRTRVVQAAEARDQALAKEKRMLEYRERAAAANGKGANGLLEDRKPAQEELSTVALLLYVAGGFLVVLAITLGFAWVLLTYFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1J5</accession>
    <name>A0A4Q9P1J5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">cysteine synthase</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cysteine synthase-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_914607</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1J5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P1J5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="70"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="248"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU64417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="468" mass="51051" checksum="76BC5A174467B33C" modified="2019-07-31" version="1">MGLSDVLHRLPTGSSARQLFYGVLIGIALSLTATSVNEYFQERKRKRAPLVFEPRPIELRSDEVVDGVAGLIGNTPLVRINSLSTALGVEILGKAEFMNPGGSVKDRVALRMITDAEQHGLLHPHTGSRIFEGTVGSTGISIATIARAKGYEATIIMPDDVAEEKVKALFALGAHVERVRPASIVDKKQFVNLARERAKHFGNEEAENPAKAIPTHHGHLIPTFSSSVIVTTTADDALADGALMSPEEEREFELKPRGFFADQFENRSNYYAHLDGTGPEIWRQTSGSVDAFVSGAGTGGTIAGTGQYLKSKKEDIIVALADPEGSGLFNKVKYGVMFDRKEAEGTKRRHQVDTVVEGIGINRLTHNFELALPIVDDAFRVTDEEAVAMSRYLVHHDGLFLGSSSACNLIACIRLVKKFGWNNGERVVTILCDSGSRHYSKFWNDDYLAKANIPVDMHLVDRILAGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2Y2</accession>
    <name>A0A4Q9P2Y2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_870091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2Y2"/>
    <dbReference type="STRING" id="114155.A0A4Q9P2Y2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="186" mass="20604" checksum="65185FE576E06E35" modified="2019-07-31" version="1" fragment="single">MNDFDKIKDDAVPSNGLSNDIIIRSSDKVDFVIQRKLLSEASPILRDMLRMSQPPPYSAEPQDEIVGSPPVLALPEDGATISALLQFHTHGLDKDGPTLSKVRSILEAARRYRMYGVVAAFRPRLVELGKLRTDALSAFAIACSLGLDEEAETLAPLAYELRGRYVPELGDMSAGVYYRLNHYDPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3D7</accession>
    <name>A0A4Q9P3D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_877846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3D7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8214" checksum="D7262B92F2C1E54B" modified="2019-07-31" version="1">MDRICPGRHFGLAAVYINVASALHVFDFSPPVDVHGREIRIEPRMPGTDEPKTLGVQSSRVPSAPSSFEVPGDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P757</accession>
    <name>A0A4Q9P757_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_915361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P757"/>
    <dbReference type="STRING" id="114155.A0A4Q9P757"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF132">
        <property type="entry name" value="ATP-DEPENDENT ZN PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="531" mass="59468" checksum="4FF0A713DEE50647" modified="2019-07-31" version="1">MTTPMSPKEIEEAFIKVTFEEETPLQPSVGTADRFHDPWVDQASNKFSEPTTFGTRQLRKLYPNHTIVPVSDYGNSILSFPGALVQPLAPSELISSVYFVPVARRLSQIPGVLVNQIFFGSFRVAWDKYEYLLYVVKFPYGMGSQTQQYVLHEGPEEPARALVLAAGGWAAQLHQEVLVFNQGFWRKDHDMWLDLQTANWADVILKEKFKTALQKDVYGFFDSEDLYKSLAIPWKRGLIFWGPPGNGKTISLKTIMKECDAKGYVPLYVKSFKSWMGEEGSMQAVFEKARQMAPCVLILEDLDSLINDSNRSFFLNQLDGLQSNDGLLLIGTTNHFDRLDPALNSRPSRFDRKYEFADPDEEERTLYIQYWQDKLKGNRKISFPDNLVKEIAAETDGFSFAYLKEAFVSSLVVLAGYEGDEKPEFRDVLKGQVKSLRDQLDQDKDKKFSQLSLAAAVSAGARTSAPQPNASRMAQVDERSLGLARIWDAASGAVGRMPGAMPAGDGQAGASAEAHGKELRNLGLSFGRSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7L6</accession>
    <name>A0A4Q9P7L6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scd6-like Sm domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_943023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7L6"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7L6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="38566" checksum="54ECB703429D014D" modified="2019-07-31" version="1">MAALSFIGKPISLISHSDVRYRGILAGIDPVASTIQLSNVYSMGTESRRPPQEYIPPVQEPYTYIIFRASEVKDLAVDEPANQRRNVHDDPAVIGASAPQVAPNYPLYGSPSYPQQAPAGVSPQPGQAQVPPRQQQQFANRQQGQPSGSQPGQTPNGQTQANGAAPPRPAARNPSVNSATASMETIERAIGDLRVSNVTTNGATQQQRGGRRGGGRQGADHKASDLRVPATDFDFESSNARFDKAALAPSPRGTPKNDSESPEGEEKEEEKEKEPAYNPKKSFFDSLSSGSNGPGPSGGEGRGRGGRRGGGRNRREEERERNVATFGEPGGVGLMGPGAYVGGWGGYGRRGGGGRGRRGGAIGARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P899</accession>
    <name>A0A4Q9P899_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NIF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_944589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P899"/>
    <dbReference type="STRING" id="114155.A0A4Q9P899"/>
    <dbReference type="OMA" id="VCYNINE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000270">
        <property type="entry name" value="Nuclear envelope-endoplasmic reticulum network protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="267"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="458" mass="50104" checksum="34F9F9031BCE5358" modified="2019-07-31" version="1">MNSLSYLSRQFDVLASTRTPPSTPASESPSFSLDGERQTRLKRSGSTKSFLVPQPPSSSSGWILKRSHSSPAEVNPNTFSPPSASLLAPAISRKKPSRPPSRRPSVSLTESTIRPKASAASPAFRHFVFVRIILQLWHALVAAVRSLTRLQNPAPTTGAVDDVAVEDNSDEEEKDTEDESRDEKPPAIPSVLLDSTPHPPYQPAIPSPLSQPPPPYTKLPPEKELHPSPISTPPAVLDSKATAASLTPPPATRSRSVTPTPPAKKAALLMPKTLVLDLDETLIHSTCRPIPSAGGSGLLGFGGRNKGVGYTVEVVLGGRSTLYHVYKRPFVDYFLRKVSQWYTLVIFTASMREYADPVIDWLDAGRGIFSRRYFREECTQLSNGSYTKDLSKIEQDLSRVCLIDNSPVCYSINEANGIPIEGWTHDPHDEALLDLLPVLDSLRFTSDVRRVLGIRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8Y8</accession>
    <name>A0A4Q9P8Y8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_910917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145440">
        <property type="protein sequence ID" value="TBU51024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8Y8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P8Y8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="114" mass="13118" checksum="50E6E1C84CB24393" modified="2019-07-31" version="1">MGMKKDMADREKNTRKDTTTLQDTIARVRRWIFEDGTAPDGQHIKKTKLGFFSMAPVRSAFSQRFAAFGRNVYQLFVPDLLHEFELGVWKGTFTHLVRTIIAAGRDGVQKLDER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P962</accession>
    <name>A0A4Q9P962_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_803698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P962"/>
    <dbReference type="OMA" id="ATRREDM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
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        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19880" checksum="F1E86C931A6E669B" modified="2019-07-31" version="1">MSKLHRDIEELRSGTQSPRPETPEPDSRQGRRNRPEAGVQLLDDDGAVSLQLESCLKHIFAKYCTPKASAQRHGELLEPPEGAYLSPEGLDSWARDTNGAPFDDATKEELLEFMDVTDNGGLTFKGFMQVYQLQTENDEEETWRDLSAHGFDRTLRLVATRREDSDSDPRFPAQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA95</accession>
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        <name type="scientific">Dichomitus squalens</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="492"/>
            <end position="595"/>
        </location>
    </feature>
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        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
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            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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            <end position="591"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU51610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="704" mass="74878" checksum="A29202E2844A05E2" modified="2019-07-31" version="1">MTAHDESREATALPPQTKNNHVIVDEPQSAGLSTPPEEVNGLDVKSSSRKREREVSLEPATPQTTTLEIDSEKSDSKDRRTPAKKNRTSDGVLEAPQEQAEDDAKLNGSPPHETKVRQISQGVEDITWQNMKKSGSTEARPENVSWGTDRESTMEGVADAQAPAETEQTQATGDTTQGVDSQDEVIVPPLMRGENPPILDDAAGEEDTGAAAGAEHPADSHIPGAPEPSNEPTSPSESEKTVPEKVSDAPRLPSSHRRGSDSDQEKGVLKRKLGDRTVSEALVPGEIPGRNGVAVVGAMKRPRDDPEVDPNTRERKRPTPPPEEDEKQAEKKEATPPKDATPKLGGFAAYASTSSPFAKVTGPRVFGAKQLTSPWAAASGSGSSANAFSSSTANSPFSSFASSPSPFGSSAPSKDAANSSSTPEASAPQAHKRTGFEAFASATSPFASAAKRPKSPPPSTSSSVLRSRSPSRHGTPVRSVNAFSAYAVGGAQGFAAPTPRRPPAFGDASTSSSAGVFGASGSKAGGSVLDVGSESGSGEDSESGKEGKAGRKEKVVSFGERLRAEKDREDEGEEEEEQKKLNLTEQEVHTGEEDEDTVYQVRGKLFALSEQNQWKERGTGMLRLNVRTEDGGGARLIMRKEAVYTVLLNATLFKGMRCFAAQDPRYIRFSVIEHNVTTHYNLRVSNAKIAEELLEEINAHIPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAK0</accession>
    <name>A0A4Q9PAK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_834242</name>
    </gene>
    <organism evidence="4 5">
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145316">
        <property type="protein sequence ID" value="TBU51478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAK0"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="81"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="230" mass="25745" checksum="3E8F26990CDE73DB" modified="2019-07-31" version="1">MASPIENLYGALLLGTFFSLIYFRVYPNDEVNIRVLVRLVISCSYWVLTNISRTKALVITAELSIILSLVALEYSGDLASGLYRILRSYSSSRSLMENFMLYVLNTGVICDIVSWILAYAAARTAWWIAFDTATTKLYLITFLSVLNSRDMAITRGIEIFGSDATYGLNAIERAARQARAERYNAPQIPDIGPTKIDIKVATEIEGENQTTRDMMADDSDAHKPGQVFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBJ6</accession>
    <name>A0A4Q9PBJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="1" type="ORF">BD311DRAFT_811858</name>
    </gene>
    <organism evidence="2 3">
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143564">
        <property type="protein sequence ID" value="TBU21980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU52110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBJ6"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU21980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9994" checksum="677BE3E2B6DBF681" modified="2019-07-31" version="1">MTDRNHVGTYVAHVITDPRTLDRAVIVWEDLLTRHEVLEIGARFLSVEDLPTEQPVATPEELVAAMAKGRAELELDPTSKSGGLKLYPNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCH8</accession>
    <name>A0A4Q9PCH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_33764</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCH8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCH8"/>
    <dbReference type="OMA" id="RYANRGW"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0704">Schiff base</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="335" mass="35405" checksum="D5C28268F25DA790" modified="2019-07-31" version="1">MTTPIQAQTPVSTPPVPHGVGNPAGTPVVAPTRTKDKDGGASGGLGTFGVKSGLAQMLKGGVIMDVVNPEQARIAEEAGACAVMALERVPADIRAEGGVARMSDPSMIKQIVDAVTIPVMAKVRIGHFVEAQILQAIGIDYIDESEVLTPADEEHHINKHAFKVPFVCGARNLGEALRRISEGAAFIRTKGEAGTGNVVEAVRHQRSVMSEIRKASVMSEEELYTYAKEIQAPFHLLKETARLKRLPVVNFAAGGIATPADAALMMQLGCDGVFVGSGIFHSENPAKRARAIVQAVTHFNNPKILAEISEDLGPAMVGLTIDDNLKGGRLAGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF27</accession>
    <name>A0A4Q9PF27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_860130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF27"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16767" checksum="0091D918B88FD2BB" modified="2019-07-31" version="1" fragment="single">MSMLAHCGQAHTDRWCTSCKHMFKNENNLMQHLRSAVHRPARFPCPMEGCGRFFIDPAALVLHYEAGACPSGLTRSTVIRAVAEHDTEGVITNANTLCYCPEAYGGCGREFRLLSSLFQHVEHGRCGLDRSARQLNEVIDDVVKGRFVTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF72</accession>
    <name>A0A4Q9PF72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_327991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145302">
        <property type="protein sequence ID" value="TBU51611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF72"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="280" mass="30441" checksum="AEB0A3FB4CD47486" modified="2019-07-31" version="1">MDLASLLHDSPSDDLRRRQSRQDPPPDAHAQQLQQQQPSQRPPHHSPPLDRPRDQLRERERAPQDLQHPSHGHVQHPPAYRRSPPPHHTSRPPSPPRHAPQYRAPSAGADFPAHSSQRHQLPPPSSLLSDPMYDVGGHASRRQEGLPHPHDRLGPSPGHPSSSVQVQPFTLEHRTTPSLPPKPQHHHHPHSHPSHHHALSHPNTPSATYIGPPSSRSIHASPPHSHHSSHGPGQGSIPLFPTAVGPGVPPSGPPAHAPPGPPPGGMSLRISAFPPQSPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFE6</accession>
    <name>A0A4Q9PFE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145232">
        <property type="protein sequence ID" value="TBU52905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFE6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11938" checksum="F6CE77928824EE91" modified="2019-07-31" version="1">MFGLQHRKRSWLEGESRYSDYNHCILLFCTVLCCVFSGRISRYLLSLCACALLNLLYHATCAGSNEPTLCQCRLIPQISRHWGVAFINLISSVPGSCCVVAYLWTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFG8</accession>
    <name>A0A4Q9PFG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_941284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145276">
        <property type="protein sequence ID" value="TBU51927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8078" checksum="D2A6CEDABB0DEB43" modified="2019-07-31" version="1" fragment="single">MDLTIAATTHVLGHLVLLRLPFAFVSLLSSLRRSPQRTTLRRKPTGSTSSCESRTSNLKTDSADGLALVRLGEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFN8</accession>
    <name>A0A4Q9PFN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_835295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145391">
        <property type="protein sequence ID" value="TBU51126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFN8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFN8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041457">
        <property type="entry name" value="CxC2_KDZ-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18803">
        <property type="entry name" value="CxC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="293" mass="33513" checksum="F993FF10C9F7AFC7" modified="2019-07-31" version="1">MSTQSKLLEWLPFRADFLDELLRFEGCEEYIEDGNVLCSICTENFTTVRCRDCARRPLCCESCLRTRHADMPLHRIEKWDGAKFLQCSLRDIGLIVQLGHDRGTCAHPAEQPRRIIVGHTSGVQAVSVRFCECLDDNCHFMPEWCQLFRFGWFPASTHSPATTFTFDLLNTFQELSFQGKTNLFDFWRTIEHITDNSGGHDVFDCYKQLSHTMRIWHHLVMLKRFGRAHDPAGPDAMKPGELVVECPACPHPGRNILPDWEAAPPDVKSVSYFKPSTNITNDVLLDGYTPCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG76</accession>
    <name>A0A4Q9PG76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_982637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145327">
        <property type="protein sequence ID" value="TBU51406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG76"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17213" checksum="6E07A1A04E0728C7" modified="2019-07-31" version="1">MCMEALGSQVSSLHFKLESPSRPMNYISLPQAPASVWLPTTTANRQHTGAIASESFNIKGLYIAVQAVLVPNVPRSSNRVTNCRLSPGSGITQQTSSGLRLSIAVPVHTKSSPVLARLERLNTPVGRRFLGRSSWDREQTAEIFFEPFNFEVFSIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGM9</accession>
    <name>A0A4Q9PGM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145293">
        <property type="protein sequence ID" value="TBU51696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGM9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8747" checksum="2F59C24E69BEA373" modified="2019-07-31" version="1">MGTLPLTSHPNRRYKQFLSTLTWVALARCRVIRSRRPNDQKYSGSCRILWEGVHVRDFVSLPLFLSYLVLPGSVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGS8</accession>
    <name>A0A4Q9PGS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_939864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145244">
        <property type="protein sequence ID" value="TBU52597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGS8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="233"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="585" mass="66260" checksum="1AE19968FF4BA04D" modified="2019-07-31" version="1" fragment="single">MRLLSTDRAELHYFASPEAVPGGYAILSHVWDPYEQTYQDLCSLRAQCALTGENPRDRVCSKLRESCFLAERHGYKWLWADTCCIDKTSSSELSESINSMYRFYGLAEVCYAYLKDVPKGGILSSRDSAFRRSRWHTRGWTLQELIAPDIVIFLSSDWHVLGTKGELARLLEEITLVPVEVLRLEEELSNVSAARRMSWAATRQTTKEEDEAYCLMGIFGINMPTLYGEGREAFTRLQEEILKRSIDTSLFAWGQCWPVPSMPPPSPQSSRHSHIHDDKSCLLAMSPSAFASCNQISFNPPRSPPLPQGEPISSGVYSDSTGETEVFLDALDFVQPGLPTFSVTPYGLRAHVMLFEYPSYSVAVLCCSNKDGKPLGLLLQSCPVAPDPHRPLYHPGVDRFRTVALSDDFIERGVNGVFAEWKVVYIIQQARQDAGAGPRLLLNRNLSTPFRFCKEELERLLRQHLWSLETLTRVDFDWNGSPPVSLAFKHKINDKAVIILSLGRCQSTSRMDYPHWATLRFYQGQSPPNVPEHTCSEDHICQWPDRKKVFKLSVEFYGIMNFFHDITLSFATCPMNPSTTLVVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI41</accession>
    <name>A0A4Q9PI41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_831347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI41"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8324" checksum="873F4B18537ECB14" modified="2019-07-31" version="1">MKISRQMSLMTFTSYEGVQYFFILVALNVIQLGLTLSSNADLSAHVNTIAVSKHLYVLRSISRSILWILPHRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJC6</accession>
    <name>A0A4Q9PJC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_886580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJC6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6553" checksum="B7E5C36EA0BE047A" modified="2019-07-31" version="1">MCSAGSDPSLTQVRPQGSDLGSSQGDINVGASGHVNRRVGRPSATRCSLLELRLAFTGHEPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJN4</accession>
    <name>A0A4Q9PJN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_828303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145192">
        <property type="protein sequence ID" value="TBU54296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJN4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="328" mass="35729" checksum="EBED2D4815DCF234" modified="2019-07-31" version="1">MHDYVRLQTLYLLIGKMLQQYEQFRAPYAPLIIRQAEAERQYSQSYPYYLITDPPPPDVGRSVGAHDMEELAAWMQTTSITAPTCPQETYIATQHAAAGVSSMQTPPNLWPLQDGNSCQPAWLDDPYCSFDPSAFPGDGYVGGHQDATLGEGIDCAVQPEVYTDAALVPPNAAPSISVIEHLEQGTYSRKQAVKGIPAGPIYFNGENGVLLATLEPLVDGEKPAFNPNASIGVKASIRFELPQFPGHTMQVRVRHGDGQGRPAQPITLRELAATVGLELKKLMVHGAKKGEPLKQGGSEVDFDKVVLLRIEHISRGSFQPIIGIRSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK77</accession>
    <name>A0A4Q9PK77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_987521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK77"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020703098" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="40544" checksum="F8B0564DB11F8F7B" modified="2019-07-31" version="1">MDLRLTLFFALVASTCNASFHHRRQTAKPVVASTTVYPSLNMQGLNRDSCVSVAWETNQALWVCRDTQQLQSNGSPGVGLIANTASYSGLPSDKSNPQALTLTSPQGFGSLFYKLEASECLDFGACSDGTRWVGWPNTGPVVTFSFNGAISAYQFLARQNLKGLSVTNTPDYSLYHVTSQTADASKIPTTNMDISGFWTGNQVGYGNDASVVANGYAYLYGATPSGGLAVARAALTGTLGTLEDRSLYQFYVNGKWQTAIPNKNDSGITLANTRSAQGTVYFSKRWNSFVWIGGDGFPNANFYISTAPNPEGPWTSPTLFYSGAVGDSGTLTYSTVAHPALTDGTGNYIFLSYSRTITNAQGFQVYDQPLIRVDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK91</accession>
    <name>A0A4Q9PK91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_827822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="63" mass="6704" checksum="022A8C7C0635DD62" modified="2019-07-31" version="1">MRPIISSQGCGLERPAQKARVTDVPHDCSLGSRRSTALSAPALDASLRSASPGREEDKLGRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKJ9</accession>
    <name>A0A4Q9PKJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_935349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145184">
        <property type="protein sequence ID" value="TBU54616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKJ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKJ9"/>
    <dbReference type="OMA" id="HEMDSEV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000162">
        <property type="entry name" value="HAD-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="347" mass="37130" checksum="1025388A94BF5B16" modified="2019-07-31" version="1">MSINPETSFYADAVLFDMDGTLTDSIAAVEAAWGKVAKDIGQDPAYVIAATHGKRAVDNLAQFKPHIKEHEMDSEVQAFEESILFFADAYNRHGPGSQPGTPLSSGAATPALTPSNSAPASRSSSRASSFVGNLAQLAAFRRPSFLHRVSSLLSMSPNTIPEGNAATFEETIAEEEEGVTKDWRTSLEKQHQLQAWQIEAAAVDRSVRILPGVKRVMDAIPKGKYAVATSGAKTYAYGCMTRVGITPPDVTITADDKRLKAGKPAPDPFLLAAKELGYDAKRCVVFEDSPSGIRAGVASGATVIAVCTSHERSKIENCGAHFIVDTMEQVTVTPEGDRLRFEIKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKM6</accession>
    <name>A0A4Q9PKM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_935159</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKM6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8508" checksum="54DADF9D8CB19E86" modified="2019-07-31" version="1">MIWQSAAAVPRDPCTLDRHVSRWHGPLIRPAMEHLRICRHCISQKIQGREECCPENNIVKRRTRKCRRFSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL63</accession>
    <name>A0A4Q9PL63_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_951115</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL63"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL63"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000072">
        <property type="entry name" value="zinc finger protein 143 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="138"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="495"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="640"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="649"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="688"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU54884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="829" mass="88184" checksum="A792F4900A1B94AB" modified="2019-07-31" version="1">MSQSSHSPKASVASPSDPSDAAERTSPEIPPSSNSGLSSSSAASDDSAGHQCQWVGCDKALPDPESLYNHLCNDHIGRKSTGNLCLTCKWKDCGTTCAKRDHITSHLRVHTPLKPHVCDICKKPFKRPQDLKKHEKIHTEEHHAQHKHSKAITVSDPTYSSRVRGEGDKPHSIAPPAGQHHGSAARAKSSSVPLSDSSSGADFGVLPTPSPELDYAREVAAAHGRNHMYRAQSQLPTWEVLAEDVQNRSAPVSGSKRSYDYTVDEFFADVKKRRVTPAYDPHMAARLSNLAYQQSLSSATSGGPPPTSMSQGPSFPPRSVSFDIRTPEELAAVNEFLITLGRDVAGAAAHPRHQHSHSVPHANIDEASFFDPANLAQLGLAGMPGMPSAPGPGSGASYHGDSGFIPINEFSHHGPSSYASRSSQHSIQSVQFGLYPSAQDIGPGAAFPYTTNRFRAQRASATDEHLSLGGLPQFHGQSYSAQNYSHYLTPPLDMGGSAGASPLSSHSGMSTPPHSTPPHIPLTVSPESAAAFDFVRTGRAPPPVQLAPVDYSAKNMRTVIPLRSAGPSSSASPASSSCSTLATRPEPVEPKLGRVGHIGLPARLTASAASSLPSVSSIAPSESSPLYPLLTSGDEQFKLPPLASRFHTPSPSSVPAAPSREPTVSPTLSTSTLTAHRSPSPISEDSTPSPPPQRYASPPPTYASLSIEKEREREKDVAYPVLPPISALAPSYGSRDAIAQHQEELARGVGKIELEGRSGKAPITPEERRRHAALLRDLLVTINMEYRRRHGTPPAVSMAASSGMAAEVTVKEEPRGVERELRDVEMIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLK3</accession>
    <name>A0A4Q9PLK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FUN34 transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_951068</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLK3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLK3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="230" mass="25000" checksum="382387E09F14E900" modified="2019-07-31" version="1">MSHLEKAQPELATANPPPTNGYSAPGRNLYYRQLGDPGPLGLYGFASTTFILSMYNVQARGINTPNVVIGMALFVGGLAQFVAGMWEFATQNTFAATAFTMYGGFWMSFGTIFIPGSGILTAYTDINELNSALGIYLWTWFIVTFLLLVASLRRNLGLVVLFFFLTITFALLGSGKFSTAHAVALDKAGGAFGIITAFIAFYVGTAEMLNDRAQSWFVLPLGQIPKRRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLU6</accession>
    <name>A0A4Q9PLU6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="14">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_934352</name>
        <name evidence="16" type="ORF">BD311DRAFT_737623</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 14">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="14"/>
    <dbReference type="EMBL" id="ML143400">
        <property type="protein sequence ID" value="TBU31332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLU6"/>
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        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0324">Glycolysis</keyword>
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    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="15">
        <location>
            <begin position="3"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        <location>
            <position position="121"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <begin position="150"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
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        </ligand>
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    <feature type="binding site" evidence="10">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
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        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
        <ligand>
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        </ligand>
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        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
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        </ligand>
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        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
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        </ligand>
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    <feature type="site" description="Activates thiol group during catalysis" evidence="12">
        <location>
            <position position="178"/>
        </location>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU31332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU55161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="337" mass="36220" checksum="E4789A0E97031CCA" modified="2019-07-31" version="1">MPVKVGINGFGRIGRIVLRNALLHGDIEVVAVNDPFITLDYMVYMFKYDSVHGRYKGSIEAKDGKLWVEGKPIAVFEEKDPANIKWGDVGAEYIVEATGVFTTIDKASAHLKGGAKKVVISAPSADAPMFVCGVNLDAYDSKYQVISNASCTTNCLAPLAKVINDKFGIVEGLMTTVHATTATQRTVDGPSNKDWRGGRAVAPNIIPSSTGAAKAVGKVIPSLNGKLTGLAFRVPTIDVSVVDLVVRLEKSATYEEIKQAVKDASTGELKGIIDYTEDKVVSTDFTGSEASSIFDAEAGIALNKNFVKLIAWYDNEWGYSRRVCDLLVYAAKKDGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMD5</accession>
    <name>A0A4Q9PMD5_9APHY</name>
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        <submittedName>
            <fullName evidence="4">Inosine monophosphate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_856881</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Aldolase_TIM"/>
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    </dbReference>
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        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="35683" checksum="8603DA51271FE95F" modified="2019-07-31" version="1">MPIETKLTKLLGIRVPVVQGGMQWVGVPKLVAAVSNAGGLGVITALTQPSPDALRKAIQETRTLTKNNFGVNITLLPSITPPDYEGYARAAVEEGVRIFETAGNNPGPLIKYFKSKGCIVIHKCTTIRHAKSAQRLGVDALSIDGFECAGHPGEEDIGGLVLLARAAQELDIPFIASGGFADGRGLASALALGACGVNMGTRFMCTVESPIHQKIKEKIVASTEQDTVHIFRTLHNTARVYKNAVAQQVVALERRPGGAKFEDVRELVSGQRGRLVYEIGDPDYGIWTAGIVMGLIKDIPTCEELLKRIERETEEAIEGLAKLRVPEAKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMJ6</accession>
    <name>A0A4Q9PMJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_826038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMJ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF10">
        <property type="entry name" value="PROTEIN N-TERMINAL AND LYSINE N-METHYLTRANSFERASE EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="27839" checksum="8328BBC2B024A711" modified="2019-07-31" version="1">MDDFLSDSAALFGDVPHDDGTIRYGPLVLTVAPKEGKANTLLADHLFSPSLLLAELIERGLISLERKTVVELGAGCALPSLLSATLINSPSLLVITDYPDQGIIRNLTENVARNRAHYQEACSVNTAGYEWGQDASPLLEGASDHSDGFDVVIMSDLLHFDSSHDVLLQSLISLLRRTSSARAYIAAGKYTPPHVCDHFVQEARRAGIVMDEGEVEGVWRGSLEVSGGGLDREQLSVRKNMCRWWIGRWENPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNK0</accession>
    <name>A0A4Q9PNK0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_908137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNK0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="258" mass="27699" checksum="70CCE63E577E283D" modified="2019-07-31" version="1">MASSNPRDYNTEHWALWQQYADRLLAYFTGNGPNPGEPPAGYREVYCVHHRHAPLPEHRAGGPPTSGGAGAWGSGMRGVAMSEDAFGALLSQGTQWATAFSQLAQSMRGGPGPVAIARPAPIPVAPRSYYTPAKTWHGNQRGRGGYHSGRGRPQGRGGSLLGRMGRNLSQGAKNGRGAHNRGKRAGRDRRDDPPPENDVLDARGEQSEDVPMAEDAPRDAEQDITTTSEEADPTNNVPADADDSVDEEDPNGWGRLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP04</accession>
    <name>A0A4Q9PP04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_932200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP04"/>
    <dbReference type="STRING" id="114155.A0A4Q9PP04"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF24">
        <property type="entry name" value="LANOSTEROL 14-ALPHA DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="624"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU56030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="692" mass="76049" checksum="642B87071200EDDB" modified="2019-07-31" version="1">MEKRTGLFSARVRSSPRPVSLPFIPTGKIRPGGSLALGLGVRRLQQVEIPIYRICPCPAPSLVPHKASHFPLYPRVVSCAVITNLFMTMYPLGFLPLFCTFLPYSVAVNAALLVPVIVLAVWSYAVFAPRPSSAKDADDVYPVHLPGSSLAHILPFFQRRFDFINQGFELAGQAIYQFSLLRNPVIVLSGEAARRDFFQAKDLDLGAGFRFLSGAVRSRNTFCCRTPSSSSRDRSQLTLTVPSLQIPMLPGVTTDLGPGRVALIYKRLATTQTSESLSRLIPQILEDSRRTINAWGNSGILDPFDRVPELIFQTSVRSLAFSELAEDPATVKRLRELYDTLDTATTPATVLFPWLPSPTAVRKLLATKRIYDIIGKTLDDRMKNGIARDDTPQMLIDAGDERMIIIGFVMGLLVAGARSTGTTASWLITFLSGHPEWREKAADEVRRLIMNHAAQLRCSSEPRTTFAGSTEDASCSAQDQPERQSHQPPSSAPAEPSPASPPLSSLTASLASIPLSAWENDTPVLDSLIRETLRVAEPHVAMRQYLPLSHSSEKEVRAPHAYAKTLYLGGRAIPPGAYVMYPFSDVHLSSDVYQNPWRWDPGRAEMGLKAPYSYVGMGAGTTICQGKRLATLELKLVTAQVVLGFGELRAVDARGLPLPELPRPNWNDVLTCKPPPGSCYVRFERTVEVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPB8</accession>
    <name>A0A4Q9PPB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_968865</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPB8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPB8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="299"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="751" mass="84856" checksum="584518136EEE8D5B" modified="2019-07-31" version="1">MRLLDTYTGQFIQKDPGHEDTLYAVLSHTWSHNPPEDTYKQLKKIQRRYATQPQDSQTSVQGVPPSPLSPLSSLSPSLAQESMTFLPYHTSSMHKDPSPAATITTKLHPKHLHIPLSPIWDDPELSPKVRNACAIARAAGYRYFWVDSCCIDKSSSSELSEAINSMYYWYSRAAICYAFLADVPPGEDPRAAQSSFRRSRYHTRGWTLQELIAPVRVMFLSNDWQVIGSKHSLADLLEEISGIPDEALLHIKSLDEFSLAQRLSWAAKRETTRVEDRAYSLLGIVNINMPTLYGEGHLAFRRLQEELVRRVPDQSLFAWENVYDGIEPGEDILEKVSQHIRYPVIPGWQRNDWVTMRPENERFESLITDSLGVFAKCGKIRAISHEDVFRRLSLPHHLPAAEYTFTPHGIRTQLPLIPVSVRLPGIEDECATSRNYHYLAILGCEHASYPGHLLGRFCYIPLSDSGIDFLYTGYTRFKWETGELGYYGLFPLSPTTIERCRTQIQLKTVYIWYPGRSCLGSPAGSLRKPHQTISLILLRKTRDALRTRGYTAELRGPDQDHPTAHWLTLSNHRHTIVVEFHHTLEDGGREFRIRVNAKMSPLRTSAEALPPAETQPGRPGAIVFRDSMRVRWQTDAGVSSDYTRPWQSSLREQQFVFDPETSKKLVLTLGMDLAPGSFYALHVDVVSEILPVGAHEVPSDDRGPVADVPHVQGEDKRGAKDVRRAVDDGPVHALGGTAEQAGRGKMLKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPM5</accession>
    <name>A0A4Q9PPM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Microbial-type PARG catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPM5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPM5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012664">
        <property type="entry name" value="CHP02452"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019261">
        <property type="entry name" value="PARG_cat_microbial"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02452">
        <property type="entry name" value="TIGR02452 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596">
        <property type="entry name" value="DUF2263 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35596:SF1">
        <property type="entry name" value="MICROBIAL-TYPE PARG CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10021">
        <property type="entry name" value="PARG_cat_microb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF014899">
        <property type="entry name" value="UCP014899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Microbial-type PARG catalytic" evidence="1">
        <location>
            <begin position="12"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="303" mass="33102" checksum="368ED1CB978B0AF3" modified="2019-07-31" version="1">MGDRRAKLKDIAQGTLSAIEKGSYNLHDATYDLRISTELSKRNTSYYAPDSVLLSWASGAPHVPADNPNVVLLAASTLEGARFLHALLRTAETPDRTNAPKVGVLNFASAKKPGGGFLTGAQAQEESIARSSTLYPTLMTRTAQAFYTLHNRDAKGGYYTHAMVYSPGVTVVRDDDGEWVKPYQIDVLTSPAVNAGVVRKTLFGRVAGPGVEDKIEQVMKDRMARILYLFEQQRIQHVVLGSFGTGVFQNKVETVARIWADLLLKDGARFKNSFENVVFAIIGGRGTHGVFQDAFQGYGVKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRM2</accession>
    <name>A0A4Q9PRM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_572352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRM2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRM2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="2">
        <location>
            <begin position="285"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="451"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="498" mass="53909" checksum="94D890314025EE01" modified="2019-07-31" version="1">MQFTPVVPPYPSPGGGSGSPLNPPPNVIPPGTPGHPGQTPAWAQQPTGFPAQSPYVSAGFMPGTIPGSYFIPPVTLPGGATPLVQPNQGFSMDYTGFPNPGGIPGSTAGGHTPFARPGQPPTTPYMGAGTQTGYSTFQQPLPPGGMPPPMYPMGMGMGMPGGMQGGMPPFATPYMPMGMPPGMMGGMGGMGGIPGAMPAGYPFTPAAPNAPMPGAVPMQPQHSRDNRFPNPKEKQPWDQAEFVKFAEGDDYGPVLSTMLVHRMKAKIEVNPLILPPNDALDRDYLKWNMLFPTGNCQRSSDRPGRSWYNGRNAPATWPRVKSLRLISRAFPWSIDVPATSPEVGVTCGDVIEAVHTSMYTRLSQQQYDNASRQQRRLLSESFYHNRSTAHGVPGGRLQQTLLRCDWLGQDTMFGGIVDDERFVRDVCGDHLPCTFELKCVRRYPMTEAEIREQEAREREEEERVRRRSRSRATSRAGSSRPPTRPPSRVVDDSSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRM5</accession>
    <name>A0A4Q9PRM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_572150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRM5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14966" checksum="E5B73510A26310DB" modified="2019-07-31" version="1">MIELSARSWPHARSTRARPSIAWQQDTAADVSDAAAGMRCVFCACVRLARVALCRKALLRRVAVRSRRKIGRTSLCTCTYGGQGRKRVGGRKCRFALGMPGRREMERCGGDGVGWGMGCKGGQGAAGWKERWDGYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSM6</accession>
    <name>A0A4Q9PSM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4185 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_821641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSM6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021026707" description="DUF4185 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="40246" checksum="1362AC5B538A2436" modified="2019-07-31" version="1">MTLPLTLLVALLGSSVQAASYRLQNVNPAVANVTIYPSLDMQGLNRDSCVSVAWEPNQPLWVCRDTQQLQSNGQPGIGVIANTASYSGIPSDVSNPQALVLTSPQGFGSLFYQLEADECPEFGLCSDNSRWVGWPNTGPVVTFAFNGAVSAYQVLGRVHLNGLTQINDPDFSLYHVTSQTADPNTIPATNVSVSGFWTSDEVGYGNDASVVANGYAYLYGATPSSGLAVARSALTGFLGNLQDKSLYEYYVNGQWQAAVPGKNDSGVTLENTRSAQGTVYFSDKWNSFVWIGGDGFPNANFYISTAPNPEGPWTSPTLFYSGAVGDPNTLTYSTVAHPALTDGTGDYIFLSYSRVITNAEGVQVYDQPLLRVDWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSN1</accession>
    <name>A0A4Q9PSN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1348-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_550444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSN1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PSN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009783">
        <property type="entry name" value="DUF1348"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31757:SF0">
        <property type="entry name" value="SLL0781 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07080">
        <property type="entry name" value="DUF1348"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="18732" checksum="7031BE9A6B9D40F7" modified="2019-07-31" version="1">MSAIVPPFTAETAQKKVKVAQNLWNTKDPQKVSLAYKPDTIWRNRDQFMKGREEVVQFLTKKWEKENGYRLRKELFAFTDNKIAVQFFYEWYETKPDGTKQWYRCYGLEDWTFDIDGLMKKRQMSGNDVPITEEERWFKDGVDGVDLNSFPISDKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSX6</accession>
    <name>A0A4Q9PSX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_821416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSX6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="196" mass="20488" checksum="E06EBBB0A17CCB48" modified="2019-07-31" version="1">MARAPPNPQYVAVYDLPERPEPARSNPPPALLTPSQPRLATASASSAATGHNAAVGSAHVDKRRRTSGPAATPSGISASATPPATSPGGTPRNRGGTLSRGASYSPLPERVAEAKVPGIYSNLMTFLGGGRACIGFKFSQLEMKVILCLLLSKFTLTPSDKEIHWNLSSVRFPTVDGNSKPSMPMNVALYKGSVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTR4</accession>
    <name>A0A4Q9PTR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_928613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTR4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="309" mass="33340" checksum="85D6930E171B58FA" modified="2019-07-31" version="1">MASSQTIQLITEYASATRDDYCFTAAAVMFTYDAILTTGDDVRCFWGRRVTGAAVLFWLNKYLTILLCFWSISGDLKICAISSQGTSAMFYVLFLPAAAFTGMRVYALSKSLLLSSAAFVLCTVPLGINLAVFHFGLTGENVPLLGCTIVTIVSRSCLIAGDFLALCVTLVTLYRRYAAIRHAGAPKATLSNVLLVDGDILVVLNVLHLAFTLISFDLPFLEDAGDLGQFVTIISPLLISRFLLHLQSANLRTIGRGSSQALMTSHDSSIIFERVVGPIGASITSDDYLDLEEDSDCGEAANDEGVEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUK3</accession>
    <name>A0A4Q9PUK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_928133</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUK3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUK3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF42">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043859579" evidence="6">
        <location>
            <begin position="24"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="7">
        <location>
            <begin position="127"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="470" mass="52238" checksum="691D004170BF14EC" modified="2019-07-31" version="1">MHRLSGFLRIVLLLVTLVTLCHARQQCRLVSKLDVQPEGSDPQAPLSASPTSSSQTVSQTASASATPSITPFNYGKDTIRGVNLGGWFVLEPWITPSIFENTNNSDIIDEYTFGQMLDADYALDVLQNHWDTWITEDDFAAIAAAGLNHVRMQIGYWSIPITSADTNYTTSVTPYIAGAWPYLLRALGWAKKHGVHVILDLHGAPGSQNGYDNSGQRGSADWAQGDNVARTVDIVRFVADQIGGMIDVLELLNEPGGWQSDIADVIGQYWQDGYNAVRNATGTSLKVMIGDAFLGVDNWDGFLTYPDAQGVLMDFHEYQIFNYDQLEMSQDEHINYSCQVLQTLSNYAKSNLYTVSGEWSNAITDCAKWLNGRGVGARWDGTWQSNQPTFGSCDGYTGNMSTFSDDYKKFLRKYFESQVAIGEAVQGWIFWTWKAENADDWSYQKGLEGGWIPQDPTDRLYPDICSNSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV76</accession>
    <name>A0A4Q9PV76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta subunit of ribonucleotide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_878963</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV76"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV76"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="399" mass="45654" checksum="ADD14A574758BD92" modified="2019-07-31" version="1">MQAGLPVPPPSNEAHTSSVSVSPQPPRSPNAKLKHVSKTGSISSVTEEKRSPSSYEDPQERFIGEVDLPEHLEPLLTETTRRFVLFPIQYNEIWQMYKQAQASFWSVEEINLSHDLWDWNYKLTDNERHFLSYVLAFFAASDGIVNENLVERFSNEVQAAEARCFYGFQIMIENVHSETYSLLIDTYIKDPAERKFLFDAIETVPCIKKKADWALRWIADERSVFAERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGMHTDFACLLFHHLRRRPHPVRVVKIITEAVEIEKEFLSEALPVSLIGINAQLMCQYIEFVADRLLVALGNEKHYNATNPFDFMDMISLQGKANFFEKRVSEYAKANFNHTLSREGSEKPAEGSSNHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVU4</accession>
    <name>A0A4Q9PVU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVU4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6526" checksum="BD492EEAE27FDAC0" modified="2019-07-31" version="1">MSVSAQYAGPTTTMSTLLNAMTSVRDWGPAGGSQCRYATDAVGGGPSRLPLFERGCLSCQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVZ3</accession>
    <name>A0A4Q9PVZ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aspartate-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="4">1.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_878646</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the NADPH-dependent formation of L-aspartate 4-semialdehyde (L-ASA) by the reductive dephosphorylation of 4-phospho-L-aspartate. Mediates the second step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-aspartate 4-semialdehyde + phosphate + NADP(+) = 4-phospho-L-aspartate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:24286"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVZ3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVZ3"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18130">
        <property type="entry name" value="ASADH_C_arch_fung_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02315">
        <property type="entry name" value="ScASADH_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000200">
        <property type="entry name" value="Aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000016">
        <property type="entry name" value="Probable aspartate-semialdehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051823">
        <property type="entry name" value="ASADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005676">
        <property type="entry name" value="Asp_semi-ald_DH_pep-lack"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00978">
        <property type="entry name" value="asd_EA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006416">
        <property type="entry name" value="PRK08664.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46718:SF1">
        <property type="entry name" value="ASPARTATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000148">
        <property type="entry name" value="ASA_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdehyde dehydrogenase NAD-binding" evidence="14">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000148-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU58685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="369" mass="40130" checksum="D6C41E4C556EB292" modified="2019-07-31" version="1">MTNQRQYKVGILGATGTVGQRFIALLAEHPFFVIHALGASARSAGKPYGKAVNWKQTKPIPSVVRELVVQECIPERFKECAIVFSGLDADVAGDIEQAFRVAELAVFSNAKNYRRDPHVPLIVPLVNTSHFSIIPQQQRLHSPPLQKGFIVTNANCSTTGVVVPLAALERAFGPIESCMITTMQAISGGGYPGVPSLDIMDNIVPYISGEEEKIEWETLKILGGLAQGDDGLKAFDMHTKQPLRISASCNRVPVIEGHTECVSVRFARRPPPSPQQVREALQNYTSEAYTIGCPSAPRHTVFVHEEVDRPQPRLDRDYQLGAGVSVGRVRQCRVLDIKFVVLANNVAIGAATSSIINAEYAVLKGIVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXF8</accession>
    <name>A0A4Q9PXF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TBP-associated factor 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_958553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXF8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXF8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08050">
        <property type="entry name" value="TAF6C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000033">
        <property type="entry name" value="Transcription initiation factor TFIID complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004823">
        <property type="entry name" value="TAF_TATA-bd_Histone-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02969">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00803">
        <property type="entry name" value="TAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TATA box binding protein associated factor (TAF) histone-like fold" evidence="9">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00076308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="481" mass="52313" checksum="309BA2DB9E15163C" modified="2019-07-31" version="1">MNKQAPKARPAPAKVPGIYKVDSVRDVAESLNLPNLPDAVASALASDVEYRIQQVVEEAARFMRHAKRTTLTTADIDQALRVLNIEPLYGHFPHNPPAFRRALPFPQMQTAGSVYFVEDEEIEFDRVIREEKISMPKGVSWTAHWLAVEGVQPLIPENPPAAPREIDPDSAAAKTSTANGVSGSVFPLTPPSSDRPSPIQSGKQTQQQNVLVKQTLSRELQLYYTRLTSSLLPPTSDPAKRTAALASLRHDAGLSPLLSYLVHWVGEGVVNTLRGGSQTETDGKLLEVYLDVIAALLDNQTLGVEPYLHQILPSVFSILLYSSLPPSNAIHLRTTAAQILAHLLTHYSMTYPGLPTKIVKTLIVGLIDNKKSRATHEGAIRGLMAIGKEALRQGLVNRSGARTVGEKCMPGESSQLVELVMDGLKLIHPPSAHPVPLDPNSSADSELIEKLHATLGDFFAERVVSDAEWARGILSDEASVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXT9</accession>
    <name>A0A4Q9PXT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_976724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="512"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU59346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="563" mass="62156" checksum="3959573F2176F601" modified="2019-07-31" version="1">MTNVQNKTTPILVIGGGPSGLAAALTLAQNGVPVRIIDKVTSFHQASRGSGLQPRTMEVFRFLGVLDDARLHARKRVQMRSYKLPGGVEPQRTWWMHEHFERTPDRPEHPQAMSQYKTEGIFRDHLAKRGVHVELGTEPISMEQDVDGVTVTVKKVASDGSETTETIRAAYVVGADGARGFTRRAIGATYEGQTKEEDGQVWADAEVEGVDSDYWHVWPQPGKFTIGIRPKGEEGKFHVGVIGQNFDPVDLVDEKKLVDFIHENTGRKDLVFKNFTSLTYWKPKMRMVNKFYEGRVFIVGDAAHVHSPSGGQGLNTSVQDSLNLCWKLALAHKGLASPILLPSYQAERLPVVTHMLIATSNLYTHLVPKKSEDVQAANANMDKNGFLQWRDLSLRMYEVNYRWSPVVFDARGTLGFDEDEMRARAYEGYPGGDVRAGDCAPDAPALLDVGGNETALFSIFKPYHHTLLVFTTEGGADVDAVVRAAQEYPEGTVRTVVIGRDGVPPTVAGAVAYHDKEGHAHRAYHVSDGPLAIFVVRPDGYVGGFAQDLEGLQSYFSRVFGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYW1</accession>
    <name>A0A4Q9PYW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_876239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYW1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYW1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="400" mass="43114" checksum="2A6C17552E8DF96A" modified="2019-07-31" version="1">MMYAPDGFEGLKPSGGKAPARKFASAFHDPKRSRSSPKDTPLGMPARAKPPLSQSLLGGPSDVLPLRIQQPPLLAPDPPQAGPFKHPAGPAFAGKTVPVRLPKPPSFASASVSSSKFTLKRHIPVLPPERNISSSRAKPLAKASIQEFLPPLPAREPAKPARSIYAIQPPLPPPLRRGPALPDAANLKTISTTRVAIATDPRTESGVDEIMALGLGQTAPTFVPPAERELIRGLKQSPEKASKSKAAKYIRGGLADRAQHLFSKRHTALTLWSKDMQLQAQRSKEHRPVAPDLALRIFEVAHITSVASLQRSHNAPRLAIVKCAHIVKGRTTGDVTVLLDFSSPGTAAGRAHTLDEVKEGKDLHIWCPYNSSDLSAEELRRFGALPRDGTTLFCTRFRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYX6</accession>
    <name>A0A4Q9PYX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_816590</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYX6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYX6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
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    </dbReference>
    <dbReference type="Pfam" id="PF02824">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF07973">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="75"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="342"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU59839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="728" mass="83137" checksum="ADE2997E330927A6" modified="2019-07-31" version="1">MTSPVASTSQPAQLPALDAPHKDQAPKKPKDKKKEAASAHPLELNPRPEFFDHRIKLFDKLKAEYDEWLKNQPRQEITITLPDGAQRKGTSWETTPLDIAKAISQGLADKVVIAKVNGELWDLERPFEGSASLQLLTFDDEEGKRVFWHSSAHVLGEASERHYGCHLCIGPPTDDGFFYEMAIQDRPVVNSDYPALEKLADLAIKEKQKFERLVVPKETLLEMFGYNKYKKYIIETKIPDGTSTTVYRCGPMVDLCVGPHIPHTGKIKAFMVTKNSASYFLGDAANDSLQRVYGISFPDKAQLKEYKAFLEEAAKRDHRKIGKEQELFFFNDLSPGSCFFLPHGTRIYNTLIELMRSEYFKRGYQEVISPNMYHSKLWETSGHWQNYKDDMFTLDIEKEKWGLKPMNCPGHCLIFDSRDRSYKELPIRMAEFGIVHRNEASGALTGLTRVRRFVQDDTHVFCMPSQIEEEIAALFDFMQHIYGLFGFDFGLELSTRPDNYLGEIETWNQAEDQLTKALDKFYPGKWELNPGDGAFYGPKIDIKIKDALRRSFQCATIQLDFQLPERFNLKYRAADEAAAADAGRPPPRPVMIHRAILGSLERFIAIITEHFAGKWPFWISPRQVLVVPVAVPYREYATEVAEKLTKLGLFVDVDNGENTLPKKIRNGEIAQYNFILVVGQEELDSRSVNVRNRDDVGTKARTETLPLDVIAEKLSILKETRSLHNKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZX6</accession>
    <name>A0A4Q9PZX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZX6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="637" mass="71941" checksum="9DC6DBDCE36F9FE0" modified="2019-07-31" version="1">MRHPGRIHNRIRSDLPPDLPAERAATPARFPWPLVIDVFLEYDDKELLMALGCLCRPFRERTRAALFRSIHIDVCPTQESKSRDLTYLSRLLGKRWRNVRNIGDWIDFLRKRPWAQAAITDVTISGRPWLQKRPTSSNSVAPGPAYNGGGIRERLRSLSLSRNNAASDPSQWEYVPPQFSIHLLSYLLTVVRGIKVLSLDTLTFDNNMHSWVADSIPRLSDVTALTTLSISRCVSTTRGHLIDALFIFPFIEELSVSYPGPQDGVPMLADDAQVSAANIALELARRRVVPRILKLSLNSLDLERSEARIAALEDFIWFAHGQDNRSLSAVRLRARTWSEARHLGTFLSRGEFASPVTSLELDVSQMLFSPVDPFRTWAELGLGATENLRDIVLWLEIPPSYDRKLSPLGPEGLFDKVLHLHADLFESFASRWSEVREVTFCVSFPRAEIGNAFFAALGHRKRGPWRRFRNKFTRMGALQEVHFRFTVPRDFPDAQTLKRRLWDATGEVLGLTSHKKHGPLWRDKELSAAVTLEGQGVTATVAAFGTSWYAQRSYQAKKEESKSPAAIPTWEYRMTSTQEHQPQSNSQEPLIHRTRGDSMEPVGPKDVPTPKDPAQPGTGQSATLSKVQQLQSFKDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q093</accession>
    <name>A0A4Q9Q093_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_947332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q093"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="223" mass="24919" checksum="D480823B1D4A80B1" modified="2019-07-31" version="1">MPSASAIYDLLADTAWVDRQRITHMRLTAHTYQNLRVFSNFVRRTGATFRTLYLRANMDWDIPETPLVASHPISLAPCAALESLVLCFRCSSDSAHAQVYMVPSMLRAYTRLFFEHRGALPALAHVRMDAGSDPFISLAQDRDHGEDGTQNTHVGPGMQGDPQLWTNLENALLGLPALERVEFGFDEILCSDRDAGAIKEALESALDRRLPRLQQQGTVRVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q109</accession>
    <name>A0A4Q9Q109_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_310177</name>
        <name evidence="2" type="ORF">BD311DRAFT_721233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143416">
        <property type="protein sequence ID" value="TBU29034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q109"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="356" mass="37897" checksum="AD6DAA81AC256985" modified="2019-07-31" version="1">MSSASASAASGAAAVIPHLPPLDKMFLIGIWVETVLYGINILVYGSAIYVLVGRIGGTTKSSSHLLISVSTLAFMLSTAYIAVTLRQLLEAFVYSPPGTATLYFANESSRLAQSKLGLYTVNVFLQDLILIWRLWTLFGRRFYVVILPLILELVRLAASITAMVRGGQPGVPIFDPLIHKMGIVDWTFDLALNIGVTLAIAARLWYMGRTVSDYVSSGTGIGSRGNKYNKVIFTIIESGGLFATATLVTVSLYLSGNIATVVAIDSITQLATITPLLIIVRVGLGLTHGSTFGGRRGESTTALGTAQSTIPGGPMTFAPRQVQISVSKVHDSDTMVDEYPLSSMHSGDLKYGGAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1H2</accession>
    <name>A0A4Q9Q1H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_257270</name>
        <name evidence="8" type="ORF">BD311DRAFT_183268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143404">
        <property type="protein sequence ID" value="TBU30611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1H2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1H2"/>
    <dbReference type="OrthoDB" id="5428495at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU30611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="459" mass="50075" checksum="95D5CD16DACEFBE6" modified="2019-07-31" version="1">MMSAIPSPAALSLDFIVVGGGIGGLAVAYVLSKAGQRVRVLEKNGMDLPSGGHRVPPNFSKILRQWMGEEELRKLSVRCVGSPSFNLRTGEVVGYLEWKPAVLAETGGDFLLMHHKDLVRTLHKLATDAGAIIDYNTEVTSVRQGTEEDAKPSVTLANGDVITADILVGADGCRSLVRQVVLEEEDCAEPGGMTLYTGVVDAEDMLDDPDLAPFILSDEWAIGMAPGRSMAGHPVAAKKQYAYHIYSWNNLYGLPQGGEETWDEIYSTANLDTNAYGLAVQKALKLTTNLIRTQWKTRDKVDEWVDSTGRIVLLGDAAHPSFPGGTHGTSMAVEDAVVLGSLFSHLNMIDQVPSFLSAYQELRQRRCELVNAADIGNARMVALPDGPLADKRNADMRAKNDDWDEGTLKAQFEEIAEIFAYDAGDAAEEWWVNWGRFSAAAREQPSMTDFFSGITMHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1U2</accession>
    <name>A0A4Q9Q1U2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1/phocein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_846504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1U2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1U2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="241"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="565" mass="61343" checksum="2C9ADDCCF5674B06" modified="2019-07-31" version="1">MTVVIQRPLKGSRISSFYPVKSLPPLSALDSAFQLQEYISLLIRLDVHDVDRIVSIPGRSANDSQDGGDGKEEKDGERDGSAGVNVDEACWVYEQLRRLAQDLSHPLITMLQQECTRSTCPEMKAGEWLYLCVAHGNEGAMEQCCAIDYILHTLDSATALLNSPRAFPSRLSVPPSSHRHFSSLARRLGRIFAHAYFHHREAFEQAEAESSLYARFLALTSKFDLVPAEFLVIPPRLSAMGDDGRPDHVEPPRLLGASLDPRRDLSAGAHGDPNEWSLSDRHVGRERLDDRSSPAPPSARRNESPRKFGRNRTDTMVYSEAFSVAEELAKGDLSEVDIDREIEAERAAAAVGADFPTSAAADVATTASPVDESSSHGPEEQEEEREEEASQADVEAPVEKAEPEHQNEAAEEPSSQTEEPGAPQTADPAQAQSALGEEEATEETHAQESASGEAHEEPQPQTEESASAPAAEATAAEAEPTGATSAEHEEEEEEEEEAEEEDSGEEEEESSDEESDVSSTVVGVVNEKPASAPEAETAQKEEGKEGEETKTEKASPAEGERTEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q323</accession>
    <name>A0A4Q9Q323_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_920951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q323"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q323"/>
    <dbReference type="OMA" id="YEPHRID"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
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        <property type="entry name" value="GST_N"/>
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        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
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            <dbReference type="ARBA" id="ARBA00047960"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="224" mass="25550" checksum="8A5883E9533825D7" modified="2019-07-31" version="1">MSHGKQFTLYTHLGGPNGWKVAIVLEELGLTYEPVYLDFTKGEQKGPEHTKYNPNGRIPTLIDHQNGDFAIWESDAILLYLTDKYDTEKKLTVTGDKEKYTLIQWLFFQSSGQGPYFGQAFWFLKFHSEQLPSAIERYRKETLRVFSVLDSVLSKPENGGWLVGGKPTIADLSFITWNNGALNFSIKGYADVEKDYPAFYAWHQKLLARDAVKKTLAIQASLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3X8</accession>
    <name>A0A4Q9Q3X8_9APHY</name>
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        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_872614</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
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            <begin position="376"/>
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            <begin position="160"/>
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        </location>
    </feature>
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            <begin position="29"/>
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        </location>
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            <begin position="115"/>
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        </location>
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            <begin position="758"/>
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            <begin position="39"/>
            <end position="53"/>
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            <begin position="54"/>
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        </location>
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        <location>
            <begin position="787"/>
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        </location>
    </feature>
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        <source>
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        </source>
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        <source>
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    </evidence>
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    </evidence>
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            <dbReference type="EMBL" id="TBU61800.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="822" mass="90950" checksum="D534CD145A26AEBE" modified="2019-07-31" version="1">MGGKKGRLSNVRDTRAAADRSSLDFESFHISSNPVSRRASPIPLTSVSSSSIASERDLDTGRSDLAESGYDSRSDVAEPSHLSHIGAFAPFDSAHNIRIIQAPVAQATVILQPSSSGSRSFHSEQHTRRATHADGVVGDGPDVTSSVLPPSFGPGPNDAWGSCVKALRDYDEHMVRGWKEDIDSLLVFSGLFSAVLTAFNIESYKLLQQDPTETSAALLARISAQLAGNSANGPSSPSTSPPTFHVSSRAVRINILWFSSLVLSLVSASIGILTKQWLREYISNTASSHRENARIRQLRHDGFIRWHIPLTIALLPILLQIAMALFFAGLLDLLWSLHPAVAGVVTVLVTISLSFLVFTTLLPTLRGDCPYKSPQAMGVFLTAQAFMRLLSYLARRLYSFLGWDRRQWPIYVETSLFRHRSRIVSGWLRSLVHRKYFGSWREREKAIAREVEAKLDHRILAGADAMFMDDVFLERVVRACISDTEEPAAVDCLHEIIYHRADGMMDGIPHWRHAEDVDGGVALLLHLVADVLPRIDKGEVASIEKTLLIADRLCRAIPFEDFKHRSETIYLYQRLFESLSVFLVHEESIKRASFDLMRSLWGKMEAPVASSVIQSLIKFARLAKQADEVNTFHLACEMALSLSTRPDLPLIVFNKIRDDLQGILEDLEGYLTASDHGTNALGSGQSGYILLALEELAALDPDLISINLVRILDHVRLDGPPKTGLVSDTESLPSHWKRRLASARAVRKLRAQDLEALNLRLPKTPEKYKETQTQQQHSASTAPIVEHLSPSSVLHSSPSHRHAALPSRPSTVPEGSEPEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3Y8</accession>
    <name>A0A4Q9Q3Y8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_147209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8407" checksum="4AF09F47A49E9CC3" modified="2019-07-31" version="1">MGKMRRCSTGDTGAYTFCCVCATWCLFLDALLQNLAHTLFLYYATLTMIFRRFRPGVPEISHFTSRTTSAPTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q415</accession>
    <name>A0A4Q9Q415_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_920467</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q415"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q415"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="402"/>
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        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="488"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="530"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="572"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="614"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="656"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="697" mass="78586" checksum="8E1ECAEC18AEBF06" modified="2019-07-31" version="1">MSPVLPWELIESVVDQACHDFDLLHSFSLTCRQLHSRSLLVMINHIPLNSRDKAFAFYDFLRTDTGLRLREHVRSLTISPVDVPHLPPLHMLPNLSTLSFISRKLERYYHEEGRPTVRLHTSHLWCYHRYGQNIRTLELGHLSLSACIDLCRLILAFPNTTKIICHDIIVKGPAMSGPVMDVLGAKLSRPQLATVNIHSGVDESVTSLLLDCARSTVQTLMLTGLHDILPAFSMPSEWKWLHTLTIGLELGKGADSLGRLTEFLKNFRPPSLEDVSVHFLVTHRHILNQCFDDERLEETNWIDVCSKLEAALSTFRRQRLSFLVSLEKPAREHLWTRELGQLFPALRDRGRLTVACKSIAAVGHERLVWAVVVSPDSKWIASGSWDNTIIVWDSDGRLCDEWMAHYSKLNSLAFSLDSRFLASAGSDRKVVVWDLNQDARRVATLEGHSDEVLSCAWSPDGTMIASGGVDKTVRLWDTKTFQQAHLFDRGHERKVRFVQFSPDGHWLASGGEDHHCCIWDVASGTLHKIFGGLTRELRAAAFDPGSTRLATASWDDTVRIWDVETAESIFVSRQHTNWVEEVEFSPDGSLLLSASWDKTVKIWDTSTGVMIMSLDGHSNYMSAAFFSPCGRYIASASMDKTVRLWRTSDGSCVATFSEHQSWLRCVAFSPDGKTLSSGAHNGSVFIRRLDQVISDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5C5</accession>
    <name>A0A4Q9Q5C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5C5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6666" checksum="66AA5BF64D4F86B8" modified="2019-07-31" version="1">MQGNSGRKLRMERLPALRLLVGRYADTSKRMSRAPLTEALLRCPHFRRRRPKTSESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5G1</accession>
    <name>A0A4Q9Q5G1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon gag domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_986943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5G1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="18120" checksum="7C8759D2C6FF330D" modified="2019-07-31" version="1">MARTVADMPMRGSHKAPRTFKEHAHRVKDFLDEYETLLKHNNVTDAAQSCKVIMRYCSHDVREILETLDQTDWDTMKSQIEKIFDAEKPDQRYQKKDLSEFTRKAKVKPMTSMTRVRNYQREFQKIAGWLKKKNHITVAATRRVDSGRRSATTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5M9</accession>
    <name>A0A4Q9Q5M9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_810113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5M9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5M9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="500" mass="54227" checksum="30BA87A9BAC659A6" modified="2019-07-31" version="1">MHERCPAAVPALSLVMPHPSLPRRRSSMLSSVSDPHTPPPRNSPLPVLSPASNRKSSDSWNSSNYDGADDLEWEWKPEQTRLLSRTLDALPSHLITPFNGPVPPSNLLDKIARGVVHAKGPAEWPHSLRATRAKIVELARLRGKEDTASDTIAEEESTDPGSVQQKPSRGFKRPLHKQSSMDFVPTAAQLDPSDDAIARLSYRLQHTERMIPNPAYHPYARTSPRLRTMGSTASSTTLNSQSSCSSGSKIPRLRRSLSSISNSSDSYIQNPGVDPRVQRIRRTESFAGSALYPPGSPLKCAPSFGSISKRSSDAMSVDFSNRSDVTTSDEEEKLRSKKAKKPRVKACSPTPPATSPPAVSPAKTKQLRRTTKHISKPSSVAAPTDSSRRTSRPKMTLSRNPSILGPELPQPPPARPEHPTPIVKPRSHRKSPSSLSPPSTIPTPSPPSPSRKTPRRTKAPSSGRAIVGRKISFGNMMATHEEENVSLGAGLGLGSAFQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5U5</accession>
    <name>A0A4Q9Q5U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_870999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5U5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="499" mass="56724" checksum="AC6BE242DEE76147" modified="2019-07-31" version="1">MTTSISPKAMPAELWYPIIEMLPSVDQKTCLSVSEMFHDIALTYVFSHVSISLGLWRPFEHIDDEEVFTDDEKADLIRRADASYEVLRHIMRTPDFARKVKRVSVRAFSCAGVEMQLAIRFLADALEAIPELRGFFWHGSSPRMPLEVFKVLANSSHTTLRELGMPQELPEGAISLLSPIHDLTSLTVLDQDADEPSLIRDVLEANANTLRALRLAGETWDQCLPMPSFASLAELDIVGIQGHEELGELFAHCTHLRALSLVFTYAEDVLIPVLRAQPKALPDLDSFKIWSVDYSGDDLAVLARFLQKKKRLRRMDVMVRVDARWLAADTALLITPILEIMPKLRELQVVGLSVRVASLQKEHIQDLEVYLPDNLTALLIWVNISSSSVPADEWIELFNSRRSLRYLHLVPDFYDALKLKAAVLNNPPPNLELFGYGAQIRPIGRDPTTGAVVVRPRWPYPKVYFRTADDYGNDDWEWLLRYHGNDEDEHFMDNADAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7X6</accession>
    <name>A0A4Q9Q7X6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_808460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7X6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020497258" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="8976" checksum="8DD212C51FDCE866" modified="2019-07-31" version="1">MPLHALYVMLFGVARVLSSQSRPAARPRARGVLVSRSGFSVEAAVGHCINNTCMSLYRKIYLPTMLSFVSAVVCCSMPETPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8L6</accession>
    <name>A0A4Q9Q8L6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_525307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8L6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8L6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF84">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="30598" checksum="ED335773375D41E8" modified="2019-07-31" version="1">MPPDYELQSYWRARFEYELDFEWLGDGSDTILPHLRAHLTDPRVSARSSPSRPARLLHIGAGTSSLSERIRELYRDVYGTQVDEGAIVNTDFAENLVAREREKAEAAFAVGRSRTGMQWVCADLLKWGELEAALQPEEERHTFDLVVDKSTSDAISCGEDVSYSNPDPSIHPALNEILAAQGGKKISISPVELLAVHLASLVRPGGLWVGLTFSPHRFPFLASLEERRDTRHSHAATYWTIDEVVTVDAPTGMEGSAYAPVVQHYIFLLRRKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9Q4</accession>
    <name>A0A4Q9Q9Q4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">glycogenin glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.186</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_807748</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Self-glucosylating initiator of glycogen synthesis. It catalyzes the formation of a short alpha (1,4)-glucosyl chain covalently attached via a glucose 1-O-tyrosyl linkage to internal tyrosine residues and these chains act as primers for the elongation reaction catalyzed by glycogen synthase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = alpha-D-glucosyl-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23360"/>
            <dbReference type="Rhea" id="RHEA-COMP:14604"/>
            <dbReference type="Rhea" id="RHEA-COMP:14605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140573"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[1,4-alpha-D-glucosyl](n)-L-tyrosyl-[glycogenin] + UDP-alpha-D-glucose = [1,4-alpha-D-glucosyl](n+1)-L-tyrosyl-[glycogenin] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:56560"/>
            <dbReference type="Rhea" id="RHEA-COMP:14606"/>
            <dbReference type="Rhea" id="RHEA-COMP:14607"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:140574"/>
            <dbReference type="EC" id="2.4.1.186"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase 8 family. Glycogenin subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.186" evidence="10"/>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9Q4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9Q4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008466">
        <property type="term" value="F:glycogenin glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000092">
        <property type="entry name" value="Glycogenin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="329"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="398"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="483"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="775"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="824"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="984"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="399"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="553"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="580"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="642"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="860"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="879"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1005"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1101"/>
            <end position="1140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00057883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU63781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1191" mass="131335" checksum="057204C61E8B566D" modified="2019-07-31" version="1">MDTPYAFVTLVTSDHYLPGALAVAAALKDLHPSPPVPPEVPFQTVCLVTPESVDVSTIKLLRRAFDIVIGVEIIEQEDGRGLQLLGRPDLNLVLTKLHIFRLTQYAKIIFLDADVLPVRPMSHLFTTPHDFAAVPDVGWPDIFNSGVLVFAPGEEKFKELLELLKSKGSWDGGDQGILNEWRGDNWHRLSFTYNTTPTAVYTYAPAYERFGSQISAIHFIGPNKPWVSITYRPPGVKYSALTDKNLNTQQQSYDYDSLVDRWFDVYDRHYRSDLDPTYANFEFTHYDSVWDAGTSYGTDIARPASVPPSGAALGLDDLRKIAVEGMSSYSAAAQPRPKVGEYRSMPLDGRVDLMRPRKEPPPSKEEKKEEGSRDQSADQNLTPKQAFIVLQGGEVPIMEPLPTPLPHELPPAPYHQPLDLPSSGPSTPYQPDMSVAGQQYFPQQPTGSYFPSEAGLVHSRVNVNASPLGMRFLAPNTSYYLESEQSDDQAPPVVALQPSWKAAESQRTRPASPHIERHHRRDSTLARHGHLSPRGPGNHTPRGVQSPRGVQSPRGQHSPTQSRHSPPPAVHRDFEQSHHPPPHQHVPHQHHHQHEPHQHQHHQHNQHHQHHQHSPVSVTQEQQQTRAPRPASPPKLEWNPAIEPPPKTPPPPSAFPPDTYFPNIWDQGPGREQDASFQAFPAHLPGPISETFFHPPPPSEIPEQLLRDGQYENVIGRISDAPGESHPSPPAPDRTKVHAVFPWEEKPRHAPRRVFPASESPPPVANFIEEPAPIIKPIPKHAPSSQRPHSTAPPIALPFSLTYSNAWDTVPSIQKYATKLVRPHHSVFQPPPPDHDESWRKWDEEREREYQDRQDASSMDGDDEDEGEEDEDGGQPARLDSDGGKERNQSRRSRAGSNASLTAGKGKKYRTRGVQTIPIETRSMGVQVNVSADENDSGRKGKRSPRTSRSAGVGSGLWATSPTSPAVGSLLPGITLKVDPDQMAVGTPTVTQPPHSSLLLFPSKASPTGLRSPQTFGSPRTYSPPEVMSPKRAPSPPRTAASKPLLSPKTSSPRRPSSPRTSMTPRRLSGSQIPTSKLAGSPQTPGSPAIGPSTSSSPRQSPVLSKLSSPPLHRMSSNDTTLTSSPSTTGPVETPEGTPVLGPQSLQPRKSGRVWDPARGVDVFKRSSEEVLARFLRSGSFDEEDGQRRHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA09</accession>
    <name>A0A4Q9QA09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9041" checksum="DC1755F65447B499" modified="2019-07-31" version="1">MEISFSQISCRRHSLGCAYVCIAWIASMSRSQVVPVNFHYRLRAQGQPITSDLPSGNVSRYLRPWLSPLPRICLSSLFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA42</accession>
    <name>A0A4Q9QA42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA42"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="145" mass="15952" checksum="EE91A01F1C2BFB9D" modified="2019-07-31" version="1" fragment="single">MCRSYMTLTSESRKVVHRASSGTRLILCAHSSSTLTIFVAAEIPSLLAMFPSQMNDEGMAMSGTVLMISVVLEGVFLLTFLTIHSIGARIFFRCISVSERLRKPSAFPFLAGTAMLLLAFAHFFLSVYVSCNRYSGEVEQGRTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAH7</accession>
    <name>A0A4Q9QAH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_868615</name>
        <name evidence="10" type="ORF">BD311DRAFT_710346</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the importin alpha family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAH7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAH7"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="9">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="112"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="6">
        <location>
            <begin position="323"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU34628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="547" mass="60395" checksum="D3EF22B629723C0D" modified="2019-07-31" version="1">MESRVAQRKNEYKSKGGLKQDELRRRREEQQVEIRRQKREENISKRRNFLPSTGADSDDEGGVGSWESPLADDMIAGVFSDDPDRQLDATTKFRKLLSKEKNPPIERVIECGVVPRFVEFLRGDNAMLQFEAAWALTNIASGTAEHTQVVISAQAVPEFIKLLSSPVPDVREQAVWALGNIAGDSPACRDYVLQQGALRPLLNLLSENNKLSMLRNATWTLSNFCRGKSPQPDWDLISPALPVLTKLIYSLDDEILIDACWAISYLSDGSNDKIQAVIESGVCRRLVDLLMHPSTSVQTPALRSVGNIVTGDDLQTQVVITSGALPALLSLLSSPKDGIRKEACWTISNITAGSPQQIQAVIDANIIPPLINILQNADFKTKKEACWAISNATSGGLQEPSQIRYLVSQGCIKPLCDLLQMMDNKIIQVALDGLDNILKVGEMDKQAQGPGGVNQYALYVEEAGGMVTIHNLQQHDNLEIYKKAFNIMDKYFPDDEEAEPAVDATSFQASCFPVDTATKSYSIVHVVQRRRCCAAPGWFQLRAVKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAJ5</accession>
    <name>A0A4Q9QAJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAJ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="17490" checksum="1B6CB5321AE79D9F" modified="2019-07-31" version="1">MMNECVRKIKGRDRWCLSLNIAIPTISTLGLGYGAFSDSQHTGLSQLGPRRPISSRAFLHVSQDRYSHLATAGPAKCLMRERARPGRSTCHIDVRERSRPQLVWRAWVSYGLVRRRVRRFLDVVCTAPQASPCVFLSDSTRAGLVSAVGRHDICAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB87</accession>
    <name>A0A4Q9QB87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_972434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB87"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB87"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000003">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF2">
        <property type="entry name" value="BETA-GLUCOSIDASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020817468" description="beta-glucosidase" evidence="11">
        <location>
            <begin position="27"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="12">
        <location>
            <begin position="729"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="809" mass="85433" checksum="F8FE88431124CAEC" modified="2019-07-31" version="1">MASTFAFAMMVPFACTLALCPSLALAADACTTGSGSNLTTCSPGYACQTLNDTSICVIDQHTPSNKTPSKAVIHTEVANIAPEWAAAYAKAKPVVANLSNTDKSNLGTGLGQIGGPCIGTTPSISAIHNFSGLCLQDSPVGVRFVDGNSVFPAEINAAATWNRTLFRQRGAALGAEFRGKGVNVALGPMMNLMRAPAAGRNWEGAGGDPFLTGEVAYETVIGIQSQGVQACAKHYINNEQEHFRDSSSSNVDDNHRITVLTDLSQQHELYAHPFLRSVQANVASVMCSYNQINGTYACENDKTLNGILKGELGFQGYVMSDWYATHSTTPAANGGLDMTMPGDEFFASFSSYFGSNLVNAVKAGDVPQERLDDMATRILAGWYLLGQDSGYPAVNFNSWLPFLGDHVNVQADHASLIRTIGDASAVLLKNEKNTLPLGAPKTMAIVGTGARSAIVGPNECLDHSCNDGVLGVGWGSGTASYPYITAPLDAISDRAKADGTSISSWTLSDDANLSQDTATGKDVALVFITADSGEASYTVEGNAGDRNDLQAWHSGDDIVEQVASVNNNTIVVINSVGPIIVDAWIENPNVTAVIWAGLPGQEAGNALTDVLYGDVNPSGKIPFTIAKQEPDYSARVIYDGSGTVQINYTEGLLVDYRHFDANNIEPRFEFGFGLSYTTFAYSDLAISGSTAGGSRQALGPGSSLDPWLHDPVVNVSFTVTNTGSKAGTEVVQLYTSPPASANQAPNNLKGFDAVFLNPGESKTVTLQLSRYDFSVWDVVSQSWQIATGETGISVGASSRDLRLKSSITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB89</accession>
    <name>A0A4Q9QB89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAPA-1-like conserved region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1002038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB89"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB89"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="203"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="384" mass="41802" checksum="A54AF6F55FA2237B" modified="2019-07-31" version="1">MPPRRRVYEEESEDAASEEEAQSDPVEDDELDMDVDEDAEAEEDAEGEEVDDIDVVGDGTHDDEGVVDDKDVVEEDVEDELIDDVSDPDRLSSPAPTSGRLPTRLKIRLKLPVGGLSSTIHTSPRARRRAAAVRTSDIESEDEDEEEDDEEGTTRSTSVATAGAGARALTARQAVLANVVDSSHVALSEPPNPRKKKPLTEIEIALKREETARKRRNLTEKKLEDEKAETINRLLKKQSRARGKRNALSTAEDRPGPGEAAGEGEEEEIVEAFAPPPTMYRWVSSARSPSTPAKGEAGEAVPEPVMTLSFSVPVSALPHKEEGENVMEVDSGNGSLHIPPPPRLPPAELPKCDVQGCTSLRKYRLVRDFQKGACGLSHLKALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBH4</accession>
    <name>A0A4Q9QBH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="9">AK6</shortName>
            <ecNumber evidence="9">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="9">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_913720</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="9"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBH4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBH4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003001">
        <property type="entry name" value="Adenylate kinase isoenzyme 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="20690" checksum="4F2552BDDCB0101C" modified="2019-07-31" version="1">MSSSNKGPVIIITGTPGTGKTTHAELLAQESPVPLKHINVGEMVKQKNLYEAFDEEWQSYTVDEDKLLDELEPLASAGGIILDWHTCEIFPERWADLVVVLRCDHTKLWDRLEKRNYPLKKIQENNEAEIMEVVLDEARSSYPQEIVVELQSERTEDLESNIQRIMQWIEAWKEDRDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDA0</accession>
    <name>A0A4Q9QDA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_24803</name>
        <name evidence="5" type="ORF">BD311DRAFT_20864</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDA0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDA0"/>
    <dbReference type="OMA" id="VHEVYQQ"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:tRNA wobble uridine modification"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
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        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU35910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="302" mass="33640" checksum="2EC4FD9B229D1F68" modified="2019-07-31" version="1">MPDVQPTTVSVENPQSYEDTHVHAVYDEIAPHFASTRYKPWPIIAAFLASLPTGWIGVDLGTGNGKYLPLPADRPGSVWTIGYDRSINLLKIAKRAGDVDREVVLGDVLDNPWRKGAFDYAISIATIHHLATPARRKLAVQRLLQTISPSHGRGLIYVWAIEQDDLSKRSIPTCPNPKDSRFDIFTLINKGQDVFVPWVLAQQADPKPKGRKGKKTHAISSEESEPAPTAPSSPPKVFERYYHMFAHGELTDLVTEAALETGLVIGQPPEAIVPGRKIQGVQIVQDGWERSNYYVEVHRWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDE8</accession>
    <name>A0A4Q9QDE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_910984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDE8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16763" checksum="0CD6518B17C5E32D" modified="2019-07-31" version="1">MCGLPPGQNPSSVHPNTLLGAGTQAYATTTMQWSGYGGYGGNGNGQQQPQQPATASRKWGPVGQRLRYVENNVSYVGEAVDVIESTGGELLRLEYSNGQRPDILRVDLERTRDALTLPPHTVTRSALRDDNPPQTPEYPGTARRTRARPYLNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEC3</accession>
    <name>A0A4Q9QEC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_912706</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEC3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEC3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="103"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="345"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="507"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU66075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="645" mass="73294" checksum="AB628480DBBBC1FC" modified="2019-07-31" version="1">MELTGRRSTMAPHADPYGNARSNLPVPSTVKKPAHGHGRMSLAGPAIRAPYPMPPPSNPRQSLMRSQNVNPLLQSASKPQSYGRTPMHNNIRRGSMWQGSNQAAAPPSSQTFAKDARPLRDKSFQAKMRQDLGSFLMSTGFDVAPQMLQNITGKDFRAVFQHLIICLDPLWPFELELRFEDHFIQALRAMKYPYVGQIDVRWLPTPAAMHSWPSLLGMLHWLAELGKARERYMTSGHPTLQDPTLVPDEFDDINHHLALALDHNTTAYEVFLQGQDVFPEQEKLLEERYARKDARVLSDLEQRREKLMEIQTDWEQLKKSAPPFEELKKDNGSLKRDKLKFEEILRRFEERRQKWLRQVQDEKTELEYNLADLERLRAEEERLLGIVKEQNLSPEEVLRMNTEHQNLTRELEALKHKKHETSQVVVRLEVSLTRKVSDAEEALDQYTALLSALGLFPPLPPPLEGVDLALDLRPAAAGAQGLLVGADVRSVVKPALNRVAEMKMTARAEVESERIRVDDELDQLTLECETVEEEVLEVMGKTNALNDQADELREAAQQEALVSNAEASRLERDLAAARTAAMANGVGVKSRLQALQIAYREQIEKVNRLREDTVRAVIKNSSDIVAFKDEVSKQLQYLRDFAEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QF39</accession>
    <name>A0A4Q9QF39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_9548</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QF39"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11678" checksum="66DA00B09CEF36E3" modified="2019-07-31" version="1">MSSPHAGSGKLHCSTFARTWSMWRACKITAMLLLERSRSGSNRSTISSPARLTVLCAGVCVATPSPCSKVAHAYFFSSRLFTTSIMYVMWLNASARLVWESIRSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5R0</accession>
    <name>A0A4V2K5R0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_951131</name>
        <name evidence="13" type="ORF">BD311DRAFT_741253</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="ML143463">
        <property type="protein sequence ID" value="TBU25318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5R0"/>
    <dbReference type="STRING" id="114155.A0A4V2K5R0"/>
    <dbReference type="OMA" id="LYANEQK"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU25318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU54900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="295" mass="33513" checksum="03BE78B3AB7E5D9F" modified="2019-07-31" version="1">MSQYTTRLIGAPNTLEHRVYLEQNGSPISSWHDIPLFADQNNGILNMVVEVPRWTNAKMEISKEEPFNPIKQDVKKGRLRYVRNCFPHHGYIWNYGAFPQTWEDPQQTHPETKAKGDNDPLDVCEIGEQVGYVGQVKQVKVLGIMALLDEGETDWKVIVIDVRDPLASRMNDIEDVERQLPGLIRATNEWFRIYKIPDGKPENNFAFSGEAKNKKYATEIIHECHEAWRRLISGESAAKTASYDLSIRNLSVQGSPGYTSKNDPAYTSLPPDSRKPPAPIDPSISKWFYIASAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6H0</accession>
    <name>A0A4V2K6H0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_258158</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145264">
        <property type="protein sequence ID" value="TBU52143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6H0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="18039" checksum="3641C025037CBDBF" modified="2019-07-31" version="1">MIWGSYLPCPVFHLALICPSRTRIGQNIHVQHSGASEVACLRPPIRPAPFPSESSLFTPSAERLAVRHQLHYPGGELEWMLPDGYEVSLHKYCTAADSNRLSSEELHRARPSKRRISGQHRVCLHSHQLWGYVIHRPQRICDIRCLRDCHPCHLYHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6L3</accession>
    <name>A0A4V2K6L3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_831736</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145241">
        <property type="protein sequence ID" value="TBU52683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6L3"/>
    <dbReference type="OMA" id="STCAGQN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF1">
        <property type="entry name" value="CONSERVED FUNGAL PROTEIN (AFU_ORTHOLOGUE AFUA_1G14230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24045" checksum="050A31A69F8C3CA1" modified="2019-07-31" version="1">MKGQPTTGYAYCPIDKFVPLFPSGQNTLVAPSNPKFLGLAFGTQNYTCSSSNNYTSTGAVAELIDASCLAFVPEFSTIQEDMYNVWTTLIPQPIQSIIDLLHFLNPPTILAQHFFQTNPVTGQGVSPVWDFRSNPRFKGNNDVFVLAKGKGSIPAPTDPKKDVAWLDVVNVQGKIADEVFRFDTVGGQPPATCKYGYDKDISVKYVSKYIFYGGSINYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6R8</accession>
    <name>A0A4V2K6R8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ketopantoate reductase PanE/ApbA C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_166877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145220">
        <property type="protein sequence ID" value="TBU53233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6R8"/>
    <dbReference type="STRING" id="114155.A0A4V2K6R8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF43">
        <property type="entry name" value="KETOPANTOATE REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="1">
        <location>
            <begin position="9"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="2">
        <location>
            <begin position="213"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="401" mass="44004" checksum="9BE3FF872CBAABCB" modified="2019-07-31" version="1">MTTHAIKDVLLIGYGAVGAVYSFILKNNGRARVTVVARSNYEAVRANGMNLHSRKYGDHPGWRPDRLFPKISDALDRPYSYVVLATKAIPEIQTTPALLAPLLSPPYCDIHPQPTYVLFQNGLNVEVALYDALKKLKPQEEPRIISTAVWIGTGLTEKNTVEHNEFDRVSLGVYRPPSTSPVAENTPAEADLLAAFSDIIAHGGSETTIVHEIQRVKFAKNMWNGVLGASSALARHSLREFFRPPHLEPGYTGPQPEAPTMAADQIERQGASQKATVSIPHASEAIGAYSIPFLYDTLSEVYDLGTVLYPPSESGAVKGLDPDLVNRTLANTARLHARPDSTHLPSMLMDVQAGRPMEVEHVVGEVVRMGRRAGVSMPRMEALYALLLVMQNQFLRKQRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6S1</accession>
    <name>A0A4V2K6S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145218">
        <property type="protein sequence ID" value="TBU53293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6S1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14063" checksum="3375C9C1EB2D560F" modified="2019-07-31" version="1">MVSTSFSLSLHSSFIVTLPRLDTAFPSQVISWLRAISASRILLPLKLSLQCRGRSLEAQVHCQSYVWDRRHRAVPHSPPSKTSRTAQISCSTSVHFNSYTLTAQTVHFVHACGLPYAHLIYAPQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7U1</accession>
    <name>A0A4V2K7U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_821562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7U1"/>
    <dbReference type="STRING" id="114155.A0A4V2K7U1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="43"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU57448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="433" mass="45171" checksum="2ADA5177C9AD3EF3" modified="2019-07-31" version="1">MCSLKPPQSAAVTSSASAPSGTPVGATGTSGSSGNSSSLGDEVVATTWYAGWHGTDFPPENISWSKYSAATYAFAVTTPDVNSVSLADSDEELLPRFVDLAHQNGVKAMLTIGGWTGSTYFSSAVATEANRTAFVKTMTGLISKYDLDGLDFDWEYPNKQGAGCNIISQDDSQNFLSFLQALRSQVGDNITLTAAAGITPFAGPDGTPMSDVSGFADVLDWVAIMNYDVWGSWSTYVGPNAPLNDTCASAADQQGSAVSAVNAWTAANFPANQLVLGVASYGHSFSVPNSAALSGSGAALAPYPAFDASNQPMGDSWDAQSPESNMCGVVTPAGPSGIFDFWGLVEGGFLTMNGTAASGIDYRFDECSQTPYVYNPSTQVMVSYDDRSSFTAKGKFISEQGLLGFAMWEAGGDYNDILLNAISEAIGIDDVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8Y0</accession>
    <name>A0A4V2K8Y0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endopeptidase S2P</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_919810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8Y0"/>
    <dbReference type="STRING" id="114155.A0A4V2K8Y0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031293">
        <property type="term" value="P:membrane protein intracellular domain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905897">
        <property type="term" value="P:regulation of response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001193">
        <property type="entry name" value="MBTPS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325:SF3">
        <property type="entry name" value="MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE-2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13325">
        <property type="entry name" value="PROTEASE M50 MEMBRANE-BOUND TRANSCRIPTION FACTOR SITE 2 PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01000">
        <property type="entry name" value="SREBPS2PTASE"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase M50" evidence="6">
        <location>
            <begin position="180"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M50" evidence="6">
        <location>
            <begin position="471"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="575" mass="63396" checksum="0C442127B573DB74" modified="2019-07-31" version="1">MVGRLQHFLFSLSLFWAVLYALRHYRRRRTSNAAFLPAPTSSTKSLSCELLRSRTTRITLSKFHIGVYSTAFNNVHQHFAARLKHSRWKRLLGFAYDAGSLLGVLGMLGSVLLLLWTTLHLVSSAHVIQTPISSAPRTLHKREELFGETLLSSESSSQDAPLQLIIPGVTTPLHHLPILFAALSATQLIHEAGHAVAAALDSVVLGSAGLGLTFILPSAFVSFAAGETESLPPRSRLRLISAGAYHNLLFWLFLSGIAWTNVSYHVWTVLGYQDVTAYGRVVIHIDESSPLYGHLPVGSVVYKVGDDTLDGPQGAPSRWESLLSNKRDGPAPTLGWCTDEAWFAVQNATCCITRPSSSEVFMGQSCFAPIADPSFERCVDPLLFLDAPDTRRCSSVVDCGHGQLCNRPRGDQELVSLTMHLPPWLRDGREADDVERRLVWQGDTSEILHEVEVGDWLPSYEVLPIGLPVLWDNLFLYLKTLSLSLYFFNLLPLPFLDGGQLLDVLFDWYMSRGVATDGGAVMLSALEATDVEQLPNAVQRLRQGGLPKTWWTKAVHFGVGTLLACCVLLSLKSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K986</accession>
    <name>A0A4V2K986_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_661134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K986"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="17011" checksum="256FF826D4DA558A" modified="2019-07-31" version="1">MGGSFWSSIFVCRASSEGRPHGKPSEAILLTGSLPLPANTHRRRPPRTSRCRLRGNTDVNVTGYGVRHCYPALGTVVFPWTVTRGQHVTSSTPFLNLRCAMYRLGQTPSRFPAARTHAQVIIYVQIWLRRNDNEATRSHRRKVCRPRATEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MLI8</accession>
    <name>A0A4Q9MLI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_948070</name>
        <name evidence="8" type="ORF">BD311DRAFT_323753</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143421">
        <property type="protein sequence ID" value="TBU28490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MLI8"/>
    <dbReference type="STRING" id="114155.A0A4Q9MLI8"/>
    <dbReference type="OMA" id="GGHDRTC"/>
    <dbReference type="OrthoDB" id="1560166at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="21"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU28490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="341" mass="36533" checksum="84076B8B642C9C7A" modified="2019-07-31" version="1">MPGLVEFPATYTAYAFLVPGGKLQKITVPWKFPKAGEIVVKVLACGVCGTDDICPTQVMPVPLPRVPGHEIVGDVVAVSCQETMWKVGQRVGAGYHGGHCYTCVRCRAGDYMTCQNQCIIGANWDGGYAEYVTLRSEAVVKVPEDMDPAEAAPLLCAGISTFNALRNMSISPPEYVAIQGIGGLGHLAVQFASAMGFRTIALSSDGSKEELARTLGADEFIDSSKVDQAQALQEFGGMKVIMSTAPNANVTESLIDGLAVNGTLLVLAVEPEPMKISPLSLLVKRLSIRGWPAGSPKDAEDCLAFVQAKKLKCLVERFPLHKAHEAYAHRETARFRAVIIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MQK7</accession>
    <name>A0A4Q9MQK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_918661</name>
        <name evidence="2" type="ORF">BD311DRAFT_660275</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MQK7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MQK7"/>
    <dbReference type="OrthoDB" id="188042at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009291">
        <property type="entry name" value="Vps62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053102">
        <property type="entry name" value="VPS_Associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48220:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06101">
        <property type="entry name" value="Vps62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040684236" description="Vacuolar protein sorting-associated protein 62" evidence="1">
        <location>
            <begin position="20"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="35956" checksum="279363B17228EB86" modified="2019-07-31" version="1">MVGIALSALSALAVSLSAAASPLRLAKRDPVPSFVLEHAPLSYLYSKEQWWPSDVAVHLTHVTPQVNFTNIADAVTFETIPSLASDVFLTSKDDVTTSPDWITNDAGKPDANGLSTAPSTIVLVNKPGGILDAFFFYFYSYDHGGKVLDIEFGDHVGDWEHTMVRFTNGTPTEFYLSAHSGGSAYTFDAVNKTNGRPISYIGVGTHANYATPGKHCHDLPGDLLCDQTDASFVWDLAANYRAFWFDNSTQTFSVAGGAGSGAQSIDAEGAGWLQYEGAWGDEQYPDDEHGQYCLVIGSLVDECQFVSGPTGPIKKNLGRTAVCQKESSCTVATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MRS6</accession>
    <name>A0A4Q9MRS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_949801</name>
        <name evidence="2" type="ORF">BD311DRAFT_777012</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143407">
        <property type="protein sequence ID" value="TBU30285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MRS6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9643" checksum="C3727F9BCD73D537" modified="2019-07-31" version="1">MPGPAKCINCGVSTNNHRFRCDWLHCTMMRKVADFPSPRAPEKPSSSHVTEDEPSANGIRVTVMSHVLDSGQVLLRRNNHRGIPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MUH8</accession>
    <name>A0A4Q9MUH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_397601</name>
        <name evidence="1" type="ORF">BD311DRAFT_99012</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MUH8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU31600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11586" checksum="4A1357FB0EED7C3B" modified="2019-07-31" version="1">MCRAWAPPPQASLSQLQHCGHMTPALSRNPSDAVRKVLSGQSMEVSTAYRISFARRSSAVRMQPAHRSTKISTLTGVRRLFMDALRPAEPSGDTSAISLRRHFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MW09</accession>
    <name>A0A4Q9MW09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_109520</name>
        <name evidence="1" type="ORF">BD311DRAFT_658001</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143403">
        <property type="protein sequence ID" value="TBU30842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MW09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU30842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6829" checksum="59B28BC221DC57CA" modified="2019-07-31" version="1">MVPVRQCLPYGGEENMFKSQLVLVVNDQSAIPSAAHPRRKAGATGCFRSLLMDMMIPQQHTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N148</accession>
    <name>A0A4Q9N148_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_33329</name>
        <name evidence="1" type="ORF">BD311DRAFT_750934</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N148"/>
    <dbReference type="OMA" id="GRYHTEC"/>
    <dbReference type="OrthoDB" id="3134980at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU32396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9415" checksum="AAA824579A5C604C" modified="2019-07-31" version="1">MCHNVIDGRLHLSCQHFIPMSTRQQDCLRPNCLFSRNHIHPIGCREKSCTRMMNPPQRNPIRISDSKCQDCIIRGDGRGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N1S8</accession>
    <name>A0A4Q9N1S8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_774979</name>
        <name evidence="2" type="ORF">BD311DRAFT_617847</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N1S8"/>
    <dbReference type="STRING" id="114155.A0A4Q9N1S8"/>
    <dbReference type="OrthoDB" id="2756413at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="296" mass="31731" checksum="BB53F663AA7DEE3D" modified="2019-07-31" version="1" fragment="single">MTGTNEDFDLPRWHTQSLHDSLSSSAQAAQTAAQASYLYSQGPPPQAAHRLPPINQPPSGSSRQPRINQLLDEDQQFGMVPSPYSSGGLARSLSLGGSSNASSRGRRQHHLQDDLEGAFHVDGDSSQRHTPASLYPPNVAYHAAQQGGASASAADPYQDAYYAGPNGPNVHTPKRSQTQHESGSSRAARSPQRQPQGNSFLDPYSPPSYTSAASNNYPYSPTTEQRSFQSGGYSSQTHSRSQSQTKPEPLSPSLPPSAYSPQSSGNQQLYSGPYPMDTTSPAPSSNNLSAQRHPRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDL1</accession>
    <name>A0A4Q9NDL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_934502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDL1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NDL1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24134">
        <property type="entry name" value="ASKHA_NBD_OSGEPL1_QRI7_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000012">
        <property type="entry name" value="tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="390" mass="42425" checksum="559E57B92706DEE8" modified="2019-07-31" version="1">MYHVRLLHIARSRPLPHRLPLPPPRPPSRRFTVLALESSADDTCAAVVTEDREILSNIVVNQQASLEQYGGIHPYVALHAHQRNMPVVVQRALRDAGLTVNEIDGVAFTRGPGIAGCLSVCGNAARTLAAALSKPLVGVHHMQAHALTPFLTSPPDQLPQYPFLTLLVSGGHTLLLLATSPTSFRILAATLDEAVGNAYDKVAKLLRIPYEGKAAGAAIERLCASEGEGAEIPMPRPIRGRLAFSYTGLHSAVERFLHARKGEVDERTKVGIARSFQKAAVGQLEDKLVLGMRQCAKEGLRVRCLVVSGGVASNQYLRDRLRACLDRESPDKHVSLAFPPPSLCTDNAAMIAWASMHRFLAGETDEYSLESRPVWSLEDLEREEAGPSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEE8</accession>
    <name>A0A4Q9NEE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_815840</name>
        <name evidence="12" type="ORF">BD311DRAFT_664203</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143425">
        <property type="protein sequence ID" value="TBU28075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEE8"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597611" evidence="9">
        <location>
            <begin position="24"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="319"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU28075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU60140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="633" mass="66778" checksum="D122E0656AD3F2B4" modified="2019-07-31" version="1">MLAVTRSLLPSLLAIVAAPGVWSIACPVPATPSPSSFAATAFDYIVIGGGTAGTALSARLAENPSAVVGVIEAGILHLNDPILDVPGHLASSGVGNKTYDWDFVSTPQVNAGGRNLSLSRGKLLGGSSGINGLAWDRASATEYDAWATIAGDKNWSWSGLLPFLQKAENFSKTPADPFPGISPAEAAEVEADLPHVDGFSGPIVASLNSLYFDTVTNVTVTLNNLGIQTNAEPQGGNTTGVSNIRLSLDHTQGVRSYAATAYYCSHASKPNYHVLTGAQATKIIFSKTRYGLTATRVQFISDGQQYTAHASKEIVLSAGTIQTPQLLELSGIGNSTILKSKNITPLIDLPGVGESFQEHFFAAAQWQLRPGVQTFGILRNNATFAAEQQAQYAADHTGLLAATDSLTAFLTLQDIVSQDRLQELLSIFDQEASAPGLSGLQQQQYALQREWFAQGNVPAVELILWSKGLINVEQGESYAVILGGLMHPVSRGSTHIASCDPLASPAIDPKYLSQNFDTEVLLDVLKFLQKLGQSAPFSDLVTVQTNPDPTAQTDDELLAYIRASSAGGDHLVGTAALAPQASGGVVDGSLKVYGTTNLRIVDASVFPIQIGAHSQATVYAIAEKVKFCLLKTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NI12</accession>
    <name>A0A4Q9NI12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_848199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NI12"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="320" mass="33755" checksum="510547FF75731E3C" modified="2019-07-31" version="1">MASHFSSTNTVQASASSKTSVELDYIVVVLRQDQLRSLACDSVQLPASSAAPDGPDVPVAVPHNVVTLDQHHACVLLHRSQLYLVEGASMSVVSPKDLHPSLRATAPARRPGVKTACVNCRKVAKRCDPGRPCARCKIMDLGDSCTDAPSKRGQVVRESCTALVRDHPQTLESSVVRASAASTSASNSVSNPRSTTDLFNEGLYTNFGSPNGAFQHQEPDVAGPSNARHGALDRGGWMNEAAGWQAQALTTYAQPMTHAAPSAIGQLIPVSYPMSAEMLPPFQAPSNLAYNGYAVGEPSDAFQSSQISEGPIAGGAHRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NII2</accession>
    <name>A0A4Q9NII2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_823181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NII2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13423" checksum="8CC14E7CC5A6BE96" modified="2019-07-31" version="1">MSSDRLQRVLTTTLGPWGNLTKMLYRTSKASGQHAAPLPPDSVRLPGAIDAARNPYSGAGARHAEAKSVAATTSYYVTNNGIEGVAGARGNLYTPSSYVVPGANTRRNSRPITSSTSAPVCRRYLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPS0</accession>
    <name>A0A4Q9NPS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_976509</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPS0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NPS0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="159"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="640"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="670" mass="76750" checksum="FED22BDF92735E8F" modified="2019-07-31" version="1">MHGKITLVPHVEFFAHFLSSMKTPRPAVWSHILDALNAPSLRTNMYESLPVGLVQATISPSFKIVAHPPKSHEAEHTKQSVGMGMYPADSTPTPHGNASYAAVDWFNIDLPMECKADSMEQDPSDDDEPSGEPTAYRRKDALDQILLYAELVFKRQQHMFLFMVLFLGDFVRIVRFDHSGVFATHRLNFKNRGNILVDFLHGYSHLSAAERGHDPTATRVSRGSFLYDSMQDRAARADPQDTHDYVRELFARSLDKGWPWWKLEVRGNVTKRKHHNFRPLTRKFLVGKPHFQASGVAGRFTRGYVALPLVSNDKIAKDAKFVFLKDAWRIDDADVEQEGATLEFLNDHKVKHVPTNTFNLERHSHYRLVMKEVGLPLEEFSGQLLQSVLLFGVLSPRAFEAGIIHRDVSAGNILIYKDDDGKWHGLLNDWELSKRIDDDRQTDCVGTWQYMFARALTNPNRRIVIQDELESFFHVLLYFAVRFLPHNLRDDNVQNFLDGYFNGNGYSCPLEKYFSIARGAIDIRTYNGGRDPKGRILSFHWPAPAQSSPPPELRDRPPSPEEEMQYDHPINTIITKLLTWFRAYYTSDTEPSRASSARGRSLQSIPAERAQNEALMEKLKTHKAIVSLFYHALRELAWPANDKGPDKKLQEVTRRPRGRCRRTRHGPARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSN0</accession>
    <name>A0A4Q9NSN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_950316</name>
        <name evidence="15" type="ORF">BD311DRAFT_262049</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ML143411">
        <property type="protein sequence ID" value="TBU29759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSN0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NSN0"/>
    <dbReference type="OMA" id="NFTHRVH"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000139">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000705">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="12">
        <location>
            <begin position="75"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="14">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="562"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="240"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="353"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="419"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU29759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU56159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="835" mass="90065" checksum="947326226E667E65" modified="2019-07-31" version="1">MAHYQVTSTSLTPSRPAPAAPIRRGNDIQNVLASSGYASSFSVGTSSPSGSSYAGGYTGIGGSPNRNSDMINSSHIVRSGMVAVKEDGIVSWLWRPKWLVLKEQTLSIHKNETSPQYQSQISLSDIANIERTDLKPYCLLLETKDKRIYFSLKSDEELYGWQDDIYSRSPLMGVSNPTNFQHKVHVGFDPVSGAFTGLPDAWSKLLTKSAITREDYAKDPQAVLDVLEFYTDHQKREMEEMGYSSLGGPRSAGSSYASSSTLSPYDRNTGSSYASSSTLSPYDTSSAPRFNAGTGLGGAGINKISPLNDRPAIKRQDSAPAHLNGDAVNGTQAALARAAEVVNSSHLQHANTVSAAQSNSAMRPPIPPMGAPNQLQASRPAPQRPLLSANRPAPPAPNLPKPPLPEDSPSSAELRLRAKAQGPPTQTQTTKPPGLMQQPERKDSLDRQGASSQRPNLAPAKSAPAVNQPATQPAPGAAGSTVGPPPVKPLQPAKKPTGPKEPPALMVTGAGDDERNGSVAAAAAALEKPKVEKEKRISTMNEAQIMDKLRSVVSADDPKALYSKIRKVGQGASGHVYVAKVLATGKKVAIKEMDLSNQPRKELIVNEILVMKESQHPNIVNFLDAYLVKSNELWVVMEYMEGGALTDIIENNTLEEDQIASICFETCKGLGHLHSQSIIHRDIKSDNVLLDAQGHVKITDFGFCAKLTDQKSKRATMVGTPYWMAPEVVKQKEYGAKVDIWSLGIMAIEMIENEPPYLDEEPLKALYLIATNGTPTLKKPDALSRELKGFLSVCLCVDVKSRATADELLEHEFLKKACALSGLAPLLRFRNKQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTD8</accession>
    <name>A0A4Q9NTD8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_1035718</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9NTD8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14879">
        <property type="entry name" value="MYSc_Myo17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036037">
        <property type="entry name" value="MYSc_Myo17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF45">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12 16" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10 16" id="KW-0518">Myosin</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="922"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="962"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1222"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1620"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1647"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="1675"/>
            <end position="1698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="16">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="769"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="113"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU63509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1915" mass="215448" checksum="259B136E8044FE0A" modified="2019-07-31" version="1">MAHRQSTLLQQLESVTDLATLSPISEDIIVSCIRERFMTDNIYTNIGTNALVAVNPHKYVASNSDAVLHKYAAEYRDTSPDKVRLPPHIFQLANNAYYHMRRTQQDQSIIFTGETGSGKSENRRLAIKTLLELSVSQPGKKGSKLGNQVPAAEFVLETFGNSRTLFNPNASHFGKYTELQFTERGRICGVKTLDYYLERSRVSGAPSGERNFHIFYYLIAGASAEERTHMHLSDRTQYRYLGARVPAGGRGPNQAQNEDAVRFEQLKVALKNVGFSKRHVAQTCQLIAAILHLGNLEFTIDRSRNEDAAVVRNLDVLEIVSEFLGVQPSALEAALSYKTKLVKKELCTVFLDPDGASDNRDELARMLYSLLFAWLNEHINQRLCRDDFTTFIGLFDLPGPQNMTSRPNSLDQFCINFANERLINFMQKRLFESHVQEYNNEGISRFVPHVPYFDNSECIRLLQNRPGGLIHIMDDQARRMPRKTDHTMVEAITKRWANHSSFKSGGMDRSGFPTFTINHYSGPVTYSAQNFLEKNLDAINPDFVSLLRGTTAGTSDAPAADGSGSMNPFVRGLFSGKAIATQAHPRNEDTIVSAQQPVKPMRAPSTRRKNTIKRMPTLKEGEIEEKDEDEGPASGGAPCVAGEFRQALDVLFETLEDTQSWYIFCINPNDSQLPNQLEGRSVKAQVRSVGLSEIARRNVNVFEAMMTPDEYVQRYQSLLTSLGVTEGDSRAKVEQSRNALGLQERDVVLGMSMVFLSQAAFRRLEDDLRSKDTEEQKRNRIRDAEAEAGLDPRGLSDPYAPYQVPGADTSPYAGDYGDPFNSSNQQLPLVANASPFQRADMYDDYDERKSLRSDDFDGRSAYTSHRDDGSVSNFGTESYAPSRNMFQNADAKGLLDKEAIAGEVQEGETAEVLKESSARRRWVALCWMLTFWCPTFLLRYVGRMKRLDVQQAWREKLALNMIIWFVCACAVFVIVFISPIICPTEHVFNTAELNGHSFKNSPNNVYVAIRGEVFDLTGIAANHERTVSVVPSKSILNYGGTQADDLFPVQVSALCNGISGSVNPYVVLTTKNDTDQNAQYHDFRSWTNDPRPDWYFEQMTMLRWNYRVGFVGYSPKQIKSMASTGSSVAIYKGLVYDFTTYISNPPAIATLPNNAVAPGNIDTKFMHQSIVDVFQRNAGGDVTKAIDRLNLDSATLDRQRVCMRNLFLLGKVDNRNSPQCLFATYILLALSIMMVSVIGFKFIASVNFSAARAPEDHDKFVICQVPCYTEGHASLKKTIDSLAQMKYDDKRKLLFIICDGMVVGSGNDMPTPRIVLDVLGANPNVDAEPLSFLSLGEGAKQHNMGKVFSGLYEIAGHVVPYLVVVKCGKPGEKSRPGNRGKRDSQMVLMHFLNKVHFNAPMNPLELEMYHQIKNVIGVNPTFYEYVFTIDADTTVHPLSLNRLVSAMVHDKKLLGVCGETELANAKQSIVTMMQVYEYFISHHMAKAFESLFGSVTCLPGCFTLYRLRTPDTHKPLLISNQVIGDYSENRVDTLHMKNLLHLGEDRYLTTLLLKHFSNFKTQFVRDAHAYTVAPDDWKVLLSQRRRWINSTVHNLAELIFLDQLCGFCCFSMRFVVMIDLLSTIIAPVTVAYIVYLIYLAAGEHAQIPILSIVLIAAVYGLQALVFILRRKWDMIGWMVFYILAIPIFSFFLPLYSFWRMDDFSWGQTRVVLGEAGKKMIVHDEGKFDPRSIPLKSWNDYENELWDKESNHSIGSWVPPTKMHNDGYAESQTASIYGRETFYEPAMSRAFSPAPSQMQMHMMYPPPGYQSGRNTPLSQVITPGVLHQPTPSRPATGYLDVQIPATRSPEDQDFFDGPSDAAIEAAVEEHLRHADLTTVTKREIRRRLEEQFGQDLSSRKRVINDAIDRVLLARAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV42</accession>
    <name>A0A4Q9NV42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_935280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV42"/>
    <dbReference type="STRING" id="114155.A0A4Q9NV42"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001070">
        <property type="entry name" value="Dynein intermediate chain, cytosolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="663" mass="73330" checksum="FC902E242B9CCB75" modified="2019-07-31" version="1">MSEKRRAEIEAKRAKLAELRKARADRQKADADRRLSESTGGPSGARRDVDDLVNALIGSGSRADGADTPVSSVPGTPALGHASLPGPSSVLSGRLSRQSDAASDSRYSLGTTLIQSQNGATENVIEREMTPRIVPDLIDIEQELFELPQKERVIYNKEVQTMEVETEPAAATEEEIREQILREREVAEAERLAHEQELEAESKRLDEEIAQEIREMTDEEKLIIFSAPEFLDFVEQSTKIIQRALNDNYDYIRDYTIGAESGTEASEGRIKNVCAFYDERFGKNRSITDIDWSPKYPELSCASYNKNPAALNEPDGIVAVWNLHLLERPEFVFHSQSDVLSVTFSPFHSNLIFGGTYSGQILLWDTRSKHLPVLKTPLSAAGHTHPVYAMQMVGTQNAHNLITSSTDGTVCSWLVDMLAQPQETLELVHAGHNKTSEVSITSLNFPDNETTTFWVGTEEGNVYQANRYDRAGAKAGLNQYDVYKGHSGPVMGLHFHPLVGPVDFSDLFLSCSVDWTVKLWRAKSLAKPSTAVNNVAPLYSFDEADDYVYDVKWHPTHPALFGTVDGAGKFDLWNLNHDTEVPVVSTSVGSGRALNKLRWERKDGRRAALGGSDGRLYIYDIGDMALPRESEWTDMQRTVAGIMGGGPQANGLGDDSARIVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVK3</accession>
    <name>A0A4Q9NVK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AhpC/TSA antioxidant enzyme-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_864161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVK3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22141" checksum="D1F84D6979298B89" modified="2019-07-31" version="1">MASTPTALPSPDVISNAASLNVHDSDGKEVSFGSLIKDQKTIVVFIRHFWCGICQRYVMQLASVRKEALEEANTRLVVIGCGDWKLIKNYCGLTNFKGGLYADPSRQLYHTLGLVQNLSRTPTGQEKRSYIGESALGNALSSIWEGPLKNPQFLGKQGNISQLGGDFIFGPGESCSYASRMKHTEDHVEVEELMKQAGVAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVU5</accession>
    <name>A0A4Q9NVU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_828428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVU5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="36621" checksum="F8CB6A7068AA756C" modified="2019-07-31" version="1">MPHANAIFQNCFYVANMLNGILYGVELVLYAVSTSIMLNNKDERNTRSYRLFLLLSTGLLLMITVYVAVQALFGEEMWIIHADYPGGSAAYQADHAAVWYETLGSVASVALNLISDGLLLYRCYVVWTDRRVLIFPLSLYLITFGEYLKPLVSDVIPHSNFFTGASQHVALSYATVVISLNFTLSSLICGRLLYHAHGVEHLLGRDVAQKYTGAVALIVEAALPYTLFGIAYVITLGLHSPTTILFMSLYVMFTCISPQLIIIRVVLGRSFSLENNSTSQLSSNVHFTTSISTSTPEEGVPDSGLGSVVSVEKKQRYRWSRSSGASGSSTVGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYP1</accession>
    <name>A0A4Q9NYP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_922543</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9NYP1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000051">
        <property type="entry name" value="F-box and WD-40 domain-containing protein MET30"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
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        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="7"/>
    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
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        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="608"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="754" mass="81299" checksum="1A6B7280E14FBA7D" modified="2019-07-31" version="1">MSAPSLAGNSSAYVCDTLPPPRLAGDKSCSRSPSPSPASPSAITTFDPPIIASSPEPPASSPMESATVRDEDAKQADSGAAPTQPPARKLCVRHQRMADEGTNLKLQQALDALPVAEREAVSVIWSNFSSSPHPRRALILHGLLTMCCFSQLSLLTEQLAHLIRIDPFAILPREVSLKILGYLDATSLCRAAQVSRQWRGLADDDILWRGICEQHIGQKCLKCGWGLPILEKRRAVRLPTASPCPEPVAVPQSSSQGPSSQGTSSQASSASSHSHLKRRLDADAAGASTTKKARLQTPEHGSRPATRSSSQNSTLSISSTEDPVASGSTSPNPLLAPSSRAPAVDFRTRPWKDVYCERLTIERNWRRGRCTVRTLKGHTDGVMCLQFSETLSHPSFPILITGSYDRTARVWNLETGTEVQCLSGHTRAIRALQFDEAKLITGSMDHTMRVWNWRTGQCLKVLEGHTEGVVCLRYDSNVLASGSVDTTVKVWNFRTGECFTLRGHCDWVNAVQLWDSTGTSSSCDTSLTAFENTPTSYAGSAPHIDPGKMLFSASDDGTIRLWDLCARACVRQFKGHVGQVQSLKLLMVDEGCEASAGSEGSSDREASVEPQESSSSSPSASSSPLPSSPVPTSSSTRPVPALSRQNTRERSSRQKPVLISGSLDNTIKIWDIDTGKVQRTLFGHIEGVWAVASDKLRLVSGSHDRTIKVWNREEGACTATLVGHRGAVTCLALGEDKIVSGSDDGDIRLWSFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYY9</accession>
    <name>A0A4Q9NYY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_810254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYY9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NYY9"/>
    <dbReference type="OMA" id="IRENKAN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF38">
        <property type="entry name" value="BHLH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="217"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="298" mass="31383" checksum="F5391169DC93AAD3" modified="2019-07-31" version="1">MPPPAHPPPEPPLSAISGPSLSPTPPIPTTPSSPISEPQHARIQPATPAQMFKLGRLAVGNNIPSQSSAHGGNGVSKQKEGKPVTRSSTGATSSKAKTADKAAGTQLISPALKPIRPAGGGVVTPVAASPSTPFMPPQIRKSSHKAAEQKRRDSLKTSFDDLRILLPPIPLPSEDGYPDEPILPGAMPPRGPPKGNVEGPNRGVSKLQLLRCGNEYIKVLKSRVDRRDEEIARLREEIRRLRLVVGDEAAAPPDGQEMIDLERDLDACEISQGAFARAIAGSGLRGSSVAEGDIDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3Z5</accession>
    <name>A0A4Q9P3Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_300805</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3Z5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3Z5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000017">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="893" mass="99230" checksum="FBAB830BE30E8677" modified="2019-07-31" version="1">MNNMQFTDKTQESLAAAIQLAKDYANAQVHPAHIAFALLNEGQSEGGGPSTSSLFSSVIDKAGGDTVTIRRALQKLIVRLPTQSPPPEEVSLSSAAAKVIREADSLRKTMHDSYIAQDHILAALIKDSSIAPILKEAGLTEDVVKTAIDQIRGNRRVDSKNAEQGFDALNKYATDLTALAEEGKLDPVIGRDNEIRRVVRILCRRTKNNPILIGEPGVGKSAIAEGLAQRIVNRDVPASLIARLYSLDMGALMAGAKYRGEYEERIKSVLNEVEKAIEEGPGVILFIDEFHLIMAGSGGMDAANLFKPLLARGKLRCIGATTLKEYREYVEKDPALERRFAQVIVNEPSVPETISILRGIREKYEVHHGVRILDGALISAAQLAHRYLTSRRLPDSAIDLVDEACASVRVTRETAPEAIDQLQRRKLELEVEIHALEREKDEASKERLIKARKAIADVEDQLKPLQAAYEAEKKRGDEVQNVRKRIDELKAKADEAERRYDLATASDLRYYAIPELQNRLAQLESKKAEEDLAHGSGTDVVTPEQIAEIVGRWTNIPVTRLMSTEKEKLLRMEKILAESVVGQPEAVKAVANAIRLSRSGLRNANRPIASFLFAGPSGTGKTLMSKTLATLLFDSPEAMIRIDGSEYSEKHSIARLIGSPPGYVGHDEGGQLTEYIRRKPYSIVLIDEIEKASREFYQLFLQVLDDGRLTDGQGRVVDFRNTVIIMTSNLGAAFLNDMGEGPVKPATRELVMGAIRGHFPPEFINRIDEIVIFRTLSRNNVLKIVDLRLKEVHERLADRKMTLQLDDAAKNYLMSIGYSPAYGARPLNRAIQQELLNPLSVMILSERIRDGETIKVQFDGPHNRLFIVPNHEGTGEEMDVDYDEDDIEIEEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAQ4</accession>
    <name>A0A4Q9PAQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_835486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145427">
        <property type="protein sequence ID" value="TBU51045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAQ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6076" checksum="732E17D3F3EE5426" modified="2019-07-31" version="1" fragment="single">ASFATSAMENQSALFFQDWDGDESAIADNESAIAHSESTIADDEQDDGMTPRPSTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBM7</accession>
    <name>A0A4Q9PBM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Endopolyphosphatase</fullName>
            <ecNumber evidence="3 12">3.6.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_925682</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[phosphate](n+1) + n H2O = (n+1) phosphate + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22452"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the endopolyphosphatase PPN1 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.10" evidence="3 12"/>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBM7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBM7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00842">
        <property type="entry name" value="MPP_ASMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041805">
        <property type="entry name" value="ASMase/PPN1_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012358">
        <property type="entry name" value="EndopolyPtase_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340:SF55">
        <property type="entry name" value="ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10340">
        <property type="entry name" value="SPHINGOMYELIN PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027093">
        <property type="entry name" value="EndopolyPtase_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="13">
        <location>
            <begin position="47"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR027093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU59100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="579" mass="66032" checksum="9A6A8D3F550E7A5D" modified="2019-07-31" version="1">MLEFKATLVLLLCLVPGSLSISSQVPLAAQPWDADDYAKPRRKLQGRFLHITDMHPDPHYRVGASEKKACHRGKPKKGKRAAGYYGLSYSDCDAPLSLTNYTLDFLGREWADDIDFVIWTGDSARHDNDRKHPRTTSEIYGLNRAMAKKMEEVFARKGIPVVPTIGNNDVWPHNIMMPGPNGITSEFSSIWRAFVPFPAYQVFQRGGYFSVEVIPSSVAVISLNTMYFYDSNAAVGGCEHSEPQDPGNLHFDWLDVQLETFRSRKMQVWLTGHVPPSPRNYFPECYVRYVELSLRYQDTILGHLYGHMNMDHFFLLDANQLSRPRNMSSTSDNGISTLKQKKKELYKTLMQEFSDLPKYENLDHDNYGVVNVAPPVVPTYLPSFRIFTYNTTGEPYEPGHLGEDEQPGRTPRSMKDVAGPLCADEAYENTWRCKLTQPWHSSPRSPSRRNTLWTPLGYAQYYLPDLEGADEEHRPKFKLEYLTLPASTLHPPPDDAPESENETAMATSAGRKFDWPIPKRHLPRSLRNSTTTKSKKFAPYTLDDLTIPSWTGLAKRLGRNKGKLRQRFKEFMYMGGEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC43</accession>
    <name>A0A4Q9PC43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_832512</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML145257">
        <property type="protein sequence ID" value="TBU52309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC43"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13882">
        <property type="entry name" value="CuRO_2_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU52309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="520" mass="56212" checksum="46F205BE98DBB3EC" modified="2019-07-31" version="1">MAKFMCLLSYVTLLFAASASAGIGPVTDLTITDVTVAPDGFSRAAIAVNGLVPGPLITGNQGDRFQLNVVNQLTNHTMLKSTSIHWHGFFQKGTNWADGPAFINQCPISSGNSFLYDFQVPDQSGTYWYHSHLSTQYCDGLRGPFVVYDPKDPHAHLYDVDDDSTVITLTDWYHLAAKVGPRVPLGSDSTLINGLGRSPGTPTADLAVINVTQGKRYRFRLVSISCDPNYVFSIDNHDLTVIEADGIETKPVTVNAIQIFAAQRYSFVLTANQTVDNYWIRANPNLGNIGFADGINSAILRYDGAASIEPTTSQQATQNLLNEATLTPLTPRVTPGTAVQGGVDKAINLVFNFNGTNFFINNASFVPPTVPVLLQIISGAQDAQDLLPSGSVYQLPVNSSIEITFPATTNAPGAPHPFHLHGHAFAVVRSAGSTEYNYENPVWRDVVSTGTPAAGDNVTIRFQTDNPGPWFLHCHIDFHLEAGFAVVMAEDIPDVKSANPVPQAWSDLCPTYDALSPDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCF8</accession>
    <name>A0A4Q9PCF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_244876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145258">
        <property type="protein sequence ID" value="TBU52278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCF8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="14000" checksum="3673400FCB421B91" modified="2019-07-31" version="1">MRTGKNTSIHAAHSGMRPGATSACPQVVFPPQCTYKSGRSPRIDEAALARRFLSFPHMNVHGDRLFLVKMQNRPGLVPRTSDVNLYVRRMMCVLLRGFEPCEVRTFAQEVRGPRGGEQGRKVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD32</accession>
    <name>A0A4Q9PD32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_910366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145275">
        <property type="protein sequence ID" value="TBU51955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD32"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="772" mass="84817" checksum="C69F24D34169C85B" modified="2019-07-31" version="1">MPPPSPIIFLLRRCIPYLSCAVFSSSKSPLYPGQLSGVLDLPHLYWVESTKQQGAIAVADLESLPFLQGTLLYEGAPALAAPKCVKSSHWLFETRQLCTIFAAPAPSAITNAGGVMCPSSTLTLEDAHHGPSPTSSPHHQYPSSSCNARPAFSSLGSRVLGCLDCGNMLRVLMFFFPQQDTSLRVKRICVLREYIATRKMSATEDIGRASTHLHDILANLVEGTPALESSAARPICRPSEHDLIHDVPMRPRPRPRPPLCLHMHGHLEAFPRKARFVTLVQWRRHPTNVFGGASITMSKHRLHVLSRCATSPLRLSCLTCMKGEGFPRSIQGRGEAVIELSARLSPIAADLSAEVRMWMMHRSRALPHPQPLSTHQKTNMKEEQDGTKAIKRGYVLPRNPSHLDSCRLAPSLCDARCPHFRMNAHEPVCMAMAVMHGLDCADNSIIVGTADRPVQRLTVIGTRTWPARSAGGVQSGPHRPDFKYLEESQEYLQRTQAAHDPPCVALTLNIWQIFGGGDVYWCDSGDSSIEGLDKAFLSERVPVSPQQAYSASETTTDKASDFRLAAALCHVWCVVLPEAHASCQFLISEPRKAHEGILATTLSTKLNWHGMSPIYMFPNLPIKRRSEKREPGSSGPLQAFSGSRSWAAAVMQALQHVERHSRGGGAPSTPSQPFLCRARDVIAMAQGLWEDGISLDCTPGDEEWGSLDSLSGRLTTLEWIPLDPAFSKVAKPCVASSCLRDVVCTVVTSTFPGYGGRLRRYLLVDRLNLRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEE1</accession>
    <name>A0A4Q9PEE1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="6">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="6">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TIF32</name>
        <name evidence="9" type="ORF">BD310DRAFT_938432</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEE1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEE1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="8">
        <location>
            <begin position="315"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="767"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="590"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="793"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="981"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU53274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1011" mass="113976" checksum="AC63274D4A8F3526" modified="2019-07-31" version="1">MAPFTKPETVLKQAEGLVSVGQNHAALQSLTEMFSSKRFRSTPLASLEPIMLRFIELCVELRKGRTAKEGLMQYKNIAQNSSVASIEVVVNRFIQLSDAKVQEAQEKADKAVALDVDDLEASETPESILLGAVSGDQTKDRTDRALVTPWLKFLWESYRTALETLKNNARLEAIYQQIAQQAFKFCLKHQRKVEFRRLCETLRLHLSNVAKYAHQPHSINLSDPDTLQHHLDTRFAQLNTSVELELWQEAFRSVEDVHNLLTMAKKAPRPAMMANYYEKLTKIFLMSGNALYHAAAWGRYYAVVTAMGGKSEEELSRLAGQVLVSALAVPVGIQGEEGAEETKGKNARLSALLGLTRTPTRTSLLREALSRNALKLSPATVKSLYNVLEVTFDPLTLSSSVTPLLKSLASDTVYAHYVPLLQHAVLSRLLSQLSQVYSTIKISNLLELVVPLRDIAAEGTYDDEQIEAYVMRCARRGELSIRVDHADGSITFVDSAFAAVEDPSSSTSAAALGAVQPSTSEFVRTRLGTIAATLHNSLAAIEPHIQPTEEEQQAQFAALVAAAEAERKALQIRRALVARRRELLSELSVRKEKEQASRRAEIMRKHQEEEARKAAQELRNKEVERARREIESIRVEEAKKLAQSLKEKGTLKVDINELESLNTDNLMRLQVEQLEKEKKELNEKMRVMSKRLDHIERAYRKEERPLLAKDYEIQQANDRAVFEASQKARLEAHRQAHLQDVETKKRLTRMLSDYEQMKETIAARRGEEFAKKKELAQKKMEEEKTKRRAAVLKAREEERKRLEEEERIRREQEEEERRLEEERRAEEERIAAEEEAARVAAEQKKREEEERTVALRKQREEERQQALEAARRQQQREEEALRRQAERKAAQSAQAPAPRAPPAREEPSVWRRPGVPSARAGVETPPRSESPAPAAGKYRPGALGGAGGGWRAREAAKQQGGAGDATPVRSASPAPPSPAPTREEAPKEGDGFQTVEKKVWRSSRLQARKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEI9</accession>
    <name>A0A4Q9PEI9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_887959</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEI9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="335"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="43333" checksum="2800E0C82DD126C8" modified="2019-07-31" version="1">MGGRAVGSDYPNVAIRPAIFPLSLLVTGATSLLVNITVDDTFGDPTTGVIPQYLPNDPPGVWHAGNATETDHWRTSHWTAGVLDVFEIRNQTWHDSTPANGPAQVVFSFTGTAVYIYNVVPNMVFETVTTSNMTFAIDDSVVGSFVHMPDQSGVTLYNQLVYSNTTLELTPHTIVISADGDNHSNILFDYLIYTTESSDITSSSSPTSSSTTSTAGSTLFVTTTVSPSQKVPLGAVLGAVIGGVVFLLATLSGAYFLFRRHYQLHSSLTSARANPAGTSGSDRAERGANSRSSSMTAFATAPARALMPQSTNSPLSQGDLLPASSEPSPKPSKRLAAISRRIQTLQREMSVLSASSPSIRSGNTGEGTVTVVRALETEIAALRRELAGFGLRLHGDWTTTEAPPGYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEZ8</accession>
    <name>A0A4Q9PEZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_937928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEZ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051799">
        <property type="entry name" value="NADH_flavin_oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43656:SF2">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="5">
        <location>
            <begin position="136"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="537" mass="59309" checksum="0E093EBE35C0D089" modified="2019-07-31" version="1">MAPYTDSNYADAQPLVDAEKILTPITLPCGRVVPNRLVKAPMYEHFAPLWGSGPHESFIALYQKWAAGGWGMIMTGNIQVAKDHLPLGRDLVVPDALSEETLAPWRELANTIHFGAPAASSSRIGLGGKDEDSRPLAIMQLSHGGRQSLNFYGGRRLFAPPLAPSPIRVGQMHKGQDGWLSRLAHWLFLQVPKEMTHEDIQRTIGQFVLGAQLAAQSGFDGIELHAAHGYLISEFISPKTNRRTDEYSADRDPLRFLREIVEAIRAPGVVPDDFVVGVKLNAADYARDTCELQENRALEHVREIGKWGLVDTIQVSGGDYEDPQFIDVALEYKSARQVVYESFAERSIDILSSCIPTATSRPPPLVLLTGGLNTLPRMSSALARDHAQLLGIGRLSVIHPHLPTKLSAALSRKDADFLRSEPWALSELGDPPSSYLSWRGLERALWYVCLLVWSYIPAKMPRVVGATANVNWYNYMMRRHALGQDLDFTVGTVGTMARFFLLPVPHASRTDGEGDWVWWISVAVVGVVLGMALGQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHL7</accession>
    <name>A0A4Q9PHL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Arsenical-resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_887957</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHL7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="49704" checksum="5B1BAC39FB0A9BA3" modified="2019-07-31" version="1">MNRKKDILMNTSPIENDQTASEVEAVNDGHVNVEDEFRAPAALLNKLSILDRLLTPAILVCMVVGVLIGNYLPGVQAAFSIAQFQSVSAPIAIGLIVMMWPILTKVRYEALPALLPTRHALTHILLSLTLNWIVAPFLMLALAWAALPDLPTYRTGVIMVGLARCIAMVMVWNALARGDSEYCAVLVVFNSMLQIVLYAPFALLFVNILGGGGGVEKTLHVSYGDVAISVLIYLGIPLAAGVVTRFAMLRLTSRCFFESTFLPYFGPLALLGLLYTIVVIFAYQGHHIVHNLGPVFRVIVPLVLYFVIMWSTTFAFVWWCARPRPRPAMVRGTSASMDEKEKKKRAEWSYEMAVVQSFTAASNNFELAIAVTIAVYGVGSDQALAATIGPLVEVPVLLALTWVALFLRRRLTWHTGSDVETGTTLAKEVVKEGEEAKRGDENLTIESGIEETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHZ8</accession>
    <name>A0A4Q9PHZ8_9APHY</name>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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</entry>
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    <name>A0A4Q9PIE2_9APHY</name>
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            <fullName evidence="4">Integral membrane protein</fullName>
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        </lineage>
    </organism>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
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        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
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    </feature>
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            <begin position="175"/>
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    </feature>
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        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39872" checksum="90D76B1ADEA9F861" modified="2019-07-31" version="1">MALPMFPIDESYLIAGWLESFLWGLFTLIYGMSIFSVYKRRWNGINKFTTLTISVLYILATAHMSLALVRLIQGFILYRDTIERIGPVMYFANISVRLNMAKDYIYITSVTFIKLGVGDLVVVWRLYTVWGKNLWAVLVPGLLIIGEFIAGYGSISQWFLPHPVPETMVKWGTAMFVMSMSTNIIVTAAIGGRIWWVTRRNRTAIGVYHQNRYTRIILLIVESGAVIAAAKLIEFTLFQLAPVDGLTGLNAMYIVYESMPQITGLAPTCIVYAVNSGFTRQDDYYVTNQKSTIAFRAPSAVATTNSTAFDGSNASTLALSSLEGGNGQHLKRGGSSGGSLEKMEFRCDYPTSGEMLAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIY1</accession>
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        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_909173</name>
    </gene>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145199">
        <property type="protein sequence ID" value="TBU54030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIY1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="36793" checksum="95F7CDBC2387CFB2" modified="2019-07-31" version="1" fragment="single">VRQQIWEDKERVERDRMEREKAEQERQAREEAGPSKRHRNDNDINDNNNNKIVNIMPKRKRARTETVWAPAKKTCAECKEKRITCLFSVGCLRARTCQACTRSKTKCTRGQRVDKTPAVAISDDEALVTPAGRSTPSKKVAPAEKMGPVPGSSSKAWGKEREMMAEREERLEVEWRKEEFKRKEKEIDVATTSIEADLPFSRRAWREIIVLKTLHYAMSEIWQLREELEELWREMRLTHSAISDLARSKEGVYQEYFGRITDLLEGEPSDDKGHLESDPDWAEMEEFSVAELDWELGSEAEQGRKQEAEKGPEQAQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ42</accession>
    <name>A0A4Q9PJ42_9APHY</name>
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        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_936703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ42"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6400" checksum="5AA8804B5E500C81" modified="2019-07-31" version="1">MAGVQELQQNRQSDPNMSIERVRDSASPNHIQCLGACTGRPPCAKVDVRFCAPVAFVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ53</accession>
    <name>A0A4Q9PJ53_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_936695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000116">
        <property type="entry name" value="HMGA"/>
    </dbReference>
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        <property type="entry name" value="HMGI/Y_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00930">
        <property type="entry name" value="HIGHMOBLTYIY"/>
    </dbReference>
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        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="HMGI_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
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            <begin position="220"/>
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        </location>
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        </location>
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            <end position="790"/>
        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU54096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="837" mass="90566" checksum="82F786BC5143E509" modified="2019-07-31" version="1">MRTRRRPVLQDKTPGNTPQKPKAKAVLTGKPKLVPVVEIKTKVRRSSRVKHVEAGQPMEVDGAAPAPQEQERGEALPLETGATLDDAPPKRARGRPRKATSQKKHVAPPPSPKAVDFSNGPEDINPDRRAPEEAVQDENATKAARESAAPKRGRGRPRKVLAKTQDPTPPPSPKADIDFGSDTGHDLHGADELVQDENARVLPSPTTPTVGRRAPRPRARPQVSSAPAADRAPLESLPPSSFAVDARPSSPASVPVADEESTASEAVRAILSTPSPARIIRAPIPVESTPLGRLPPLEASLRPFASSIRKWNADVSRTYSSLPPSSPPVQVPVATSSQARYQAEFSDEKEPIRYAKRKTPPSDDDLFGLLAAEKKLKTIRQRRMPVESSRAPGGTRAPLGMLALDEVPSVGVPIPDRLPTPIPSDEHNIDDLYLDVDPVRPGRSHVDEEDDEEDEDKENLPTEDYNLNEDKENMCPPHLVFDDFKENDLPPDGPDEALGDDENDENLASASVAPILLASAKKGFGLDQLLVEPSSSSASPMHALRTPHKHRSAHQRSPLPTPHFSDDGDVLEDSPATVHARSEGLGWHEESPSPVKPSAALRGKGKAVARDPVPALDKGKGKAGPSKPRQPLATLEYEDPYAEPAKVAGKKRTRAQVGAHAGLKESESEESDPRAAVMKLEALLPRRAKKARLEEANKVNKGKSKTKGKERDRENVPESTESGSGSEDEDRGVGSDSSPPKIPARAARGRGRGRGRGRGRAQAIAPTSNGRTSVPASRGRSTSRGRPPTSKGKGKERATGVVDPDEDEERLRKRQERLEYFKKLQDYSLEKEDVYVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK27</accession>
    <name>A0A4Q9PK27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <name evidence="1" type="ORF">BD310DRAFT_970954</name>
    </gene>
    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="372" mass="42303" checksum="B1C27B10C7DBE7D2" modified="2019-07-31" version="1">MEDVFPPSTEKVTKQSELAAACIKLAHNTAVAKTRCANVFFWSPTRLLGCFNDRRMGNITVETLLNWIECSMSVPSQQFDGYRLVMQGIDLEPNSPTARGTAIRCLPVLPPCGAELARNEVVKPGDYIILLKGSGKGWDEAKILDIEYRLELAECFWTLKHETSFTEKHEGDVRYEITLEVRGPATQFPHYQGRCVVTGHQSDGALKVDLHWIYPPQWVYWHPTMKHSESLTWDEKGFSVPHNVIMMDDDVYRQFHDNAFGIDMYVRGFPNGKIYTFDDSPSLEKIPESPVVAIDDEETREFFRLHFQQCLFVGIFGGDVEDDGASGKDAVDYMLNQVRLDEQEKYVFPKGKGWEDNLGKAVKAWVSLYGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKA8</accession>
    <name>A0A4Q9PKA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldehyde dehydrogenase</fullName>
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    </protein>
    <gene>
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    </gene>
    <organism evidence="4 5">
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000009">
        <property type="entry name" value="Aldehyde dehydrogenase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="477" mass="52137" checksum="60A273C0365C2899" modified="2019-07-31" version="1">MSGFSFTDGFANIIDGKKATSPTSADIIDPSTEEVWARVPIATPEQLEDAIAAAERAFPAWSATPWEERQAALNKLADLIDQHAEQVAHLLMKEIGKDRGAAAFELSISTPWLRGVAKQKLEEEVRTEDSGRVSKIRFRPFGVVAGICPFNFPLTLGINKFAQAVLAGNCMILKAPPSAPCLVIKVIELAQSVLPPGVLQVLNGGNDLGQLMVKHPRIMRVSMTGSTGGGKAIMREAGAELKSITLELGGNDPAIVLDDIDVKQVAQVLFLGATHNAGQVCFTIKRIFVHENIYDAVKEELIAIAKEVRIGNPFDPDVNMGPVQNKAQYDRLQSLLTDCKEKGYKIAFRSSPRPTGEKGYYVPLTIIDNPPDESRIAREEQFGPIVPLFKWKDDEEVVRRANGTDFGFSSSVWGKDMDRVQRIADGLYNGMVWVNEWGAVSADHPMGGTKHSGTGVECSKYGLTSWTFVQSFVVRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKL6</accession>
    <name>A0A4Q9PKL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_935496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145184">
        <property type="protein sequence ID" value="TBU54662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKL6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="135" mass="15524" checksum="65E62AC928A901F5" modified="2019-07-31" version="1">MVLRVLCTGSLRICPPYAHFNFMKNWRSAPDSYLQLLPYLEFYIVAANDSLSFYKEQLAGETKNYIHIRATTDQMTPVDMLRRVADEVLACGERVELLIGDDAQLMGIWRSFEHGVLEFHVKTQRYQLAGLTFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLN1</accession>
    <name>A0A4Q9PLN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1041364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="17"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19775" checksum="438D19D35E558853" modified="2019-07-31" version="1" fragment="single">MPGAILKRTIGDKTFPAIGYGAMGIAAAYGTPLTIEEALKVLDGVYASGVTHWDTADAYSNSEYIIGQWFKRTGKRDEIFLATKFGFGHHWEGDETRTINGDPDYVPKAVQRSLEQLGVDYVDLLYLHRADAKVPIELSVKAMAEQVKAGKVRYLGLSEVSADTLRRAYAIHPIAAVQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLU3</accession>
    <name>A0A4Q9PLU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_826347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="212" mass="23111" checksum="F841B5FCADE79EEA" modified="2019-07-31" version="1">MSTNASKMLLATLPPVPSLNSTFGAMLIGTFTGLVLYGLSLHQTLHYFLTYTGDTRLLKLMILCLSFYIRRVYLLGYGYQYVAIPATLFMLSGTASFTTACTVEAFSKTTFVAFSRVVVMYFIAVLTVLNSRRSLMSSTASSEGDFGTFGLSAPQQKSVRLPASARLDILRGPSGSDGPVIDIGKWQTPAAEQTIDRYKVRDGDSANLHEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLV1</accession>
    <name>A0A4Q9PLV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_706703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLV1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20391" checksum="8721ED5FD54A9656" modified="2019-07-31" version="1">MEGSRSTAASRRSHHPSRYALHQINRVCLLISLHPRTHNRPRPSRLLKTYCSSANASVGCSPTHPPCNISFVEFESLSSAASVLAKGREIAKAHPIRAGITVQIGKQASISSSMTLTALATFGRVGSARAEVSPLLATGLVQSTACHVTSSTSCYDGWPQALERGHEQRTRPPEREDAVTPPTRLVSANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN48</accession>
    <name>A0A4Q9PN48_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_825354</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN48"/>
    <dbReference type="STRING" id="114155.A0A4Q9PN48"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="44255" checksum="0FF4D899B6D7BAF4" modified="2019-07-31" version="1" fragment="single">HKPVLIQTFDRPRSFELFHEVREASSSPTPIHEMLRDPAILSSLLSHRKKPRSGSSASHTPRLATAGDDMLKPEPKKERDRDRDKDRERERDRERDRDSRTIDTASTTSTVKPRKKDRDRDRESDSATILTHVLAEEERQARHLKAVLRQTGARLEEELRRADLAESRARTAEINVSELTQRLASSEAARHQLELDATRAQEECRRWQMQADAAEREARRLQTELARSERARQDVEQAEKEARGAARRAEQTLREWKAREEGREEVRRLEVRRRYSDGRDEGFEDGRAEGYEAGHEDGYEQGRNEGYENGRSEGFDAGRLAGFEEGKKAAYSDGFQAGYAQGKKEERARALDAFDRFIESEMDHRRPRDSMTEYEVNTSHSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP11</accession>
    <name>A0A4Q9PP11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1040746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP11"/>
    <dbReference type="STRING" id="114155.A0A4Q9PP11"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021036040" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="27"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="174"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU56037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="682" mass="73861" checksum="0D9EC6166BA30B03" modified="2019-07-31" version="1">MGFGVALARLVVRLLALPLVSHAGLAITSSSSVRSDITLLYNNDLNVNEQSTHHGALLLSTSYLHPDASRACAALGETLLPVNKTFFATDLAHLLQYQVFQKNFPPTQQFWVAGSGPFCQIVNAKGAVSLSLTCLRELPVLCSQSAGFQALAQPETSLTVKSQDLTIVGFRDQTTFKFYGIPYADPPGRWEYPTAYTGNRTIDARNYAPACFGSGLNPSSEDCLHLNIWTPFIPSPDTKTRLKAVMFWIHGGAFTGGSGSQSLYDGSALASRGDVVVVGIDYRLSTLGFLALDDGKTNGNFGIADQIAALDWVREHIAAFGGDKDRITIFGQSAGAASVRALMGSPKAMGKYAAAIPMSNLAGANYATTYSLYYTIPEEVSLIADPIISAANCSDASDVLGCLRALDVDTLFRLGTVARYLVVDGTYIVHRQLPVDGSGEVANVHTMMGFMRDDGAGFIGYPTSGNLTEALIAASLDTSIADNALFPEPSGPNVTLNVYNVTAGATTDVEFRCLDQATAFSGVTHNLFKSVWFYEFNRSYEPPGHDPNWPTCEPPITPEHPFGDTSAEYFKCHSGELYYVFASLPADLPYRDDQDLPFTQRIVDIWSSFARTFNPNPDPGFLAARGFTSTAQQLAAQPKWEPVTKANLHGKPVQQLQWESVMVPFGQQEQCDFLGFPLTYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPN9</accession>
    <name>A0A4Q9PPN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_960374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPN9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPN9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="243"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU56226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="59572" checksum="96B98D9433934E65" modified="2019-07-31" version="1">MTDSNDTTQAEGEGPEGSDKPPHAQRNGKPRSRRSSGPAAALSGVFDPSQPHVPLPPPDSKAYAKQPGHTRKSLEDMRTKLDTLNINGGPHGKHNPSSTAGSITPSSSESPSPSECESWSVPSTQPPSRAPSMSAGVSGGKLALPVNQPLKPASKKEQPPPTAPRILPTLSAGDEKSNNKRPPSVHSDTGSQKFTLRDLLGTPKLVRRSSARSTASSKKSDSDRGGRSEAGASTISLLKKYGVCEKVAIGKGATSVVRLAHKWDRSEEKLYAVKEFRKRRKNETEKEYVKKLTAEFCISSTLHHVNVVETVDLVQDENQHWCEVMEFCPGGDLYAAIKRGGMSPSEVECCFKQILTGVAYLHSQGVAHRDIKPENLFFDMQGHLKIGDYGASTVYRLPWEQTIHMSTGLCGSEPYIAPEQFLGKPYDARLVDIWACGIVYYCLHFQELPWTVAQPTDQLFAAYVSACNTPSQSACPPTINNLSPRACRPLIRKMLEPNPKMRSLIDDIIKHPWVQGIEVCHLVDRPKHVHQSATHLAREQVHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPV7</accession>
    <name>A0A4Q9PPV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56381.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9310" checksum="FC5AEDB0C922C1AC" modified="2019-07-31" version="1">MLATECGDVWGYAWAPGPLGCGVVRCGRGRVDKVARRLHVVLSSAVKYCSHSVLAPVTFAFAACTVLIPARRGRLQQSCTCSSAGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ13</accession>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="308" mass="35074" checksum="C9A13E6E969A4C26" modified="2019-07-31" version="1">MSNDQELRKLRPRRGAPSHENEDAAKKPQTILPRPCPSTTSHAPENRPARGQQGRPEAPRKPPRAKSRRSVLDLKKEGAHAASAMTIREGLTRVRNKPLKDSERYIVGKQQIHRCGCAAAGAVDGDATTPRCKSSFPLISIKAARKHFREVHYAANEKQTDRIVRCRWIGCTKTLKFRDTGRHFSQHFGACYRCPNYPACRWGGSISRADALTRHMERCPVEREKRAAHLQADGPRDFEVSTPMPEQPEAGPSNPRKRSRSCVQDFEEEEYHDNSEQHWDPNDEYDEDYVPSKSVKKGKQHARKRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU56455.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17874" checksum="CECC21A81CB3FF88" modified="2019-07-31" version="1">MSCTTVTYAPPIQSTFVATTAFVASTSENHAFCMPPPPIVPQTPAKRRQDENAVPWGPQRHNRAKARGKRRVSFAPLPDREDVPPTPSKPAKTSRPARPALKRRYSTSQVPSRDHQLESRHLSQREGVYIMSPEEFVSMVAQDQRRSHSDASSTDRRGW</sequence>
</entry>
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    <accession>A0A4Q9PRM7</accession>
    <name>A0A4Q9PRM7_9APHY</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU56954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11980" checksum="098A94771AA532C7" modified="2019-07-31" version="1">MQRARRRGTHGDNAGQRDHPPPNPPGGTPSRLAAKRDRKPLHAKDVDCAEISLSRLLATHCSEWAEFLAGRTRYLPLSSCIDSKLKHTYVIVACRPDTSHDETSGPPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRZ8</accession>
    <name>A0A4Q9PRZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">BD310DRAFT_1020855</name>
    </gene>
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        <lineage>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="SNF2_N"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
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        <location>
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        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU57179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="755" mass="85783" checksum="191A38BD82DC25AD" modified="2019-07-31" version="1">MEGRGGLLGDDMGLVRTIQVISFLSAIMQKRGETLDIDRRRNHVSKLQDSSDWKKRRKLPAANATWPTCLIIAPSSVVGNWEREFKTWGYFEIGMYIGPPAARAEALNDFKLGRLDVLVTSFDVARMDIDLIDELPWSCIFIDEVHRVKNPRSKLASAFSRFTCKRRYGLSGTVIQNGYEELWTVLNWTNPGAVGTRKQWESYVEKPLRLGQSKSASDEEHVKAALVAKVLTEKLLPQLFLRRTKQIIQDQLPRKTDQVVFCPLTPTQVAIYKRIINLDAVKSLIYKDALCTCGSRKPRKKCCHPVHQGDLFKYMSTLIKISNHLALILPSPTDTIEQTARNRELARMAFSPGPIPKYGPAMLKPDYCGKWQVLETLLKDWKKDSNKVLIFTKSVKLLEMLEFHLNAEGHGFVKLDGSTKQSERMPVIDRFQEDPDIFIFLISTMAGGTGLNLTAANKVVIFDPNWNPAHDLQAMDRAYRFGQTRDVSVYRLLGAGSIEELIYARQVYKQQQMQVGYNASLQTRYFEGVQGDKNKQGELFGIKNIFKLHESTLATKMAIERANISDLDWAFAYMGGRGGAKRPKAKHDGVKWVYEEEAKTGKEYDEFRGLGALLFDDAAPEMTNEPNDVEKTLNSLGVQYTHRNDALIAESTIEGQRVQKLIEEKKKAAKKAKLRQKSGRDKSPEPEWPPRRRHHKPPPSPASKLQTRQRALIEQGLLQGPEDLPKFAQEFAQKSLQEQNEFLAQLDAYAKAHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSY9</accession>
    <name>A0A4Q9PSY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_554106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSY9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="22417" checksum="DD75EE7C2205D8F6" modified="2019-07-31" version="1">MVAFRLRPSPPGCLTGPTSRHLSSAACCITILTFPPCHIHVMRAPVLFIHSIPPSSLLTRFISASLVSTPSNVGFSFLIFYIPFALFTTNARTLALPTIERPIPVRVGCAVYRCICIICSVSLHLNFPLLSPHILPHVLLVLSAYVQTILRPLFPLLTPLAFDPVAHTPHHDSYRHLPRCSSADAPACTIVDIPPAGASCRRERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT22</accession>
    <name>A0A4Q9PT22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_546825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="1306"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1435"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="700"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="729"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="792"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1138"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1196"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1407"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1572" mass="168079" checksum="0113DD413C27E8DC" modified="2019-07-31" version="1">MSQPISPMANKQSQRRLSGNMLPFNRQQLPPFGDSGPAGPSAPFGYYDRYGPPEEPIAPAFREGYANEYNPNFWKPEPDFFPNIQNAPFPDRVPPPQGDGWQRPPGWREPEPPVWSGPEGRESALPVSRPPFPPPSNIRRGGGSRPPPNRMFEPSDNWKQTHERYRPYTPPGPNPNVMRNRFGFKSGPRRSFHGQPSRPFHEPQSQPFHQPPPYEDKWSPDEGAYGDNGPRRSASFSNTPTSPERMVRMASPASPRDVIHSSPSFVSEPFAPKRESPELPHLEALPPLQPVGEPIHIPLPTSLLPPKPQSRSSSHSSGSGSAAAAQSQPQPAPVQPIYGLPPKPPPQVRSRQPISIPIPNLASAHPPAPQVAPADDVEKTQVTATPSQSTQAEPQIQARTASNSRNNVRRPFNAPSFVPSTLAIDAPLMFPIGESKSSAANALDEPAKIAKDAAEAMDVSEETAPVKDVQEAVEAGSSSQSPAQTNQPAKLLKVTGKAPDSDGNAADDSDMDMSPPGSPVIKASSLPAEPLSEAASSDREASRPSLFIDTATSSPRVLHGALRQSSSASPVPTTPENADETAGDESDMDMSSPASETASSPPPEPQSTAAPASAPAPVPAKVSLPQPPAVEDDSMIPGLSIADSGVTPAPKAASPVLTSDPASLPKPVDQRTAARTPPPVAPAPPPASALSPVLVSLPVPISPSVPASPSPPAHPPTPPPTSIVREPSVQASTVTPVTATLEKSHVEVGELSPPASEETLREDTEATEKETLREDTEATEKETAEKESCPTVVAEEAAPAAPRNDVVPSTDPAEEKVLQELPLSEALRLVAKLRYRHDPMTQEARVEPILYSNRQLAESEGSASPQPEVSGQSVVEKEAEKVQQQLNDGVFGGTKHSLRKRFAQHQAALTEKVSRLRKEYMALHERWMVHCAKLDEVARASALEEAAATAGRTTRRTAAMGDAVRSDLEMEQILASLGNEELTDANHLSQKNAAVIPDMVSVTKGRVEYIYDDTNNLVEDPHEFYKLETGIDDWTEEEKQILIDKYAIHPKQFGIIADYLPNKTPAQCVTYYYLHKNTTIDFRKIIAQYNTIGKRTRRGRNAKQKGNALLADILKHDDEVSGNRDGTLSASGRRKRGTAGTATPVPPASTSTEATDSASTRKAPLSRRGTAQNTPDPTPTPDPEPSGQKRPRRRANPSAKAAAAALEADIPDEPVQDEERPVKRTRKGRKSKAELEAEAAAAGDESHTPSTPVMENKPPEQPQPEAPPKKKSGSGSGNWTEDDRGKYYPYHSSPPRLVIQEPLTALFLKLLAQHGDDFKRIASSMANKTTIQVAAFYRSHSTEMNLSKVVAQAPKRSPTPHENGLKGNKHATQVVDGNVIARSKSSGRMSPPPNPDASRPFEGGTRPPSSASTSAPPNGIPVPMYRPSAPYQGGIGSAFASTSRGNPNPLTNGLGGRPPTLTMSFPSAMAYSNLSPSSFAGQPPLSLPRSASGLPGTPGVGGSNAMMMEFSEFAPQPWQVPALTHPGGAPIVPGTAAGGGLPATLETTEDLVRYLEHRTRMSAGKSTEADFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT64</accession>
    <name>A0A4Q9PT64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_928945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT64"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6048" checksum="ADDB2961F985F937" modified="2019-07-31" version="1">MLAHYILVALVSPSFRPPWAAPSTSPPAPVARVSTFEGRMIAVPARTARLLSVCMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTC2</accession>
    <name>A0A4Q9PTC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1039705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU57693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="114155.A0A4Q9PTC2"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043971955" evidence="3">
        <location>
            <begin position="20"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="15696" checksum="6EC22F0A8F423E39" modified="2019-07-31" version="1">MLALATTLVTLSFAASAAALSTSGRRVGHAGRIAGGAIAGIIIGCIAFVLLLLLCCCLCLRSRRSSRAGGAAPSRYGGFSSFGRSGRNAAGNGMGNGAVGPGAQEAGYGTGPVVGQQGNYNDKTQPAYGGQYQPPMGAPPNAPQPGGFAAPPAAHTRAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTQ9</accession>
    <name>A0A4Q9PTQ9_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_763852</name>
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    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTQ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7745" checksum="D9B16545ABF72E8B" modified="2019-07-31" version="1" fragment="single">HQENVTDLYRYLGYLAKYLKYPKYLKYPKSNGLGQVGWVNLAKYQVLGQVLQVPVQVHAQVHCEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTX0</accession>
    <name>A0A4Q9PTX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_928301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU57931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTX0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
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    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="NusG-like N-terminal" evidence="11">
        <location>
            <begin position="175"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="482"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="12">
        <location>
            <begin position="696"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="13">
        <location>
            <begin position="772"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="799"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU57931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1098" mass="121233" checksum="39AFF577C1677921" modified="2019-07-31" version="1">MSDVEDDTMLNSGDVLEDNEQHQETRPPKSRRRDYDEEEEEEDEEDEEEEEEDDEDEGTKRGSKRAKHRHKRPAVNRFLDVEAEVDEDEDEDEDEDEYVRDEFIADAGIEGEEDYDAVRRTADHARYDRRVREMDDRDLEQVAEDISQRYRRTAVRYTGEMSDVPQRLLMPSVHDANLWQVRVRPGKERDIVFSLMRKALDLSFSNHPLQILSAFQRDSLPGMIYVEARSAKQVSEAINGLVGIFPSRGIVLVPIEEMASLLQIKQQELTVTPGSWVRIKRGKYQGDLAQVMDITENGEEVGLKFIPRIDLNPKDDSALDGKKRKKAGAGLSSFSMRPPQRFFNYEEVVKVYGRKSVAKRNQVYVFQNDTYKDGFLEKDFRLTALQLDDVNPTLDEITRFTRGQDGTENEANVDLSIIAEASRKAAISVLQPGDHVEVFEGEQSGVHGTVHSIEQDVVTIEPEGVDFDGQRVQIPARSVRKRFKPGDHVKVMTGKNADETGLVVSVLDNVVTFLSDMTMQEVSVFSKDLREAAEVGTGTNIVGNYELHDLVQIDQQTVGVIFKTERDSFRVLDQNGQVRLVQPHQITMRRDSNRAIAMDSEGHELRAGDNVKEVDGEQRKGRVLHTHQSFFAFLHNRDIAENGGVFVTRARSLASLAPKGNVMKLGGTDLSKMNPALSGGAGGMVGSGMMGRGPRDRLIGVSVTVIKGPNKGYVGTVKDTNGPHARVELLTGNKVITIDKEKLRRRNPDGSLEALERPMANMAPPRAPGFGGGQTPNPYNQGGAAGGRTPGWGANGRTPNPYNDSRTPAWSANSRTPNPYAEHGKTPAWDATARTPNPYNQGAGGKTPAWNTSSRTPNPYANGANNGAASVWGGATPGRPGGGFDSWDPRAAPTPYAAAFTPGAPTPAPYASIQTPGVYEYQTPAQTGSYPQTPGVMGGGSYGMTESPFDISPKWLLDPELADKVKGIMVEVRGTFGSAGWHNGDHEGKQGIVLSILDTQNESFTSTARVRFLEPVNPLQPILTVPVEYLWPVHPESRGEDVLILAGLQGKGQEARVEAIESRDLMVLTTKATFLVIDSPPNRLVRIKQVDEVGNFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU15</accession>
    <name>A0A4Q9PU15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_510962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU15"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020523806" evidence="1">
        <location>
            <begin position="25"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14629" checksum="BB527B7174435ED9" modified="2019-07-31" version="1">MSDFLSLSVLQLLSVLSFLTSVLAVVCVGSGSFHRLAHRVEHGVDAPAPDMSITSGKHPIWNWSGLPVSFSLDTLIGEDEEPQGYVGGTELTRMDWQVTARPRIVTTPYESRVPMSMAKLIMTRHVSISSCLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUL1</accession>
    <name>A0A4Q9PUL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_819920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUL1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUL1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="26124" checksum="0F2AF57EB9DC7F31" modified="2019-07-31" version="1" fragment="single">ISKSSTAAAPKTSQSPSKSAWARGPPANTWTAPSPRSQSPAPSVTSSSAPPKHFRRPSTLGRGIAFMDGVGAARTPSNASRSGSSVTFGSIDDTNAPISSSPAAAPTIKSEGIKTLRSASAITNGKIHARTISFSTGTPSSGAAAAASTSSSSSTPPSTSSSTALSTSGSSYTPKAAKFDVKSLFSNKTSDALSTSSAVSASPSHCTTSLPQSSLNPQGQSPHQSPPSQMDAPYSNVRPQQNSVPIASPGAPRSPSSPPPDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV83</accession>
    <name>A0A4Q9PV83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7590" checksum="8198D622D7E34AF4" modified="2019-07-31" version="1">MKKWTIRHTTCLLPEASLFPHPILSLSSRIPPRLSSFCSSLPLGIPFSLLPSHPPSVVSSPSVLVLNITS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVF6</accession>
    <name>A0A4Q9PVF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_927291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVF6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVF6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="302" mass="35671" checksum="5296F61A0DF04C80" modified="2019-07-31" version="1">MSSTPPPYETVHKYEKRPLDSPKDEASPRPPARISRLKIAFVLVLVYLDVLVLAQHFNIFSFLLDDVPLEKQNTLRHEWRREQDAHAREVAVWNHERATHVREMHAWQHELVALQDRREQWMREAEAERAQWAAERRSEELRKKEVERMRQGVHWSEAWGNQRCSAYGARAYNARLLDIPEELGWYEVCADMPNRFHGRWVDRPARCQRDRNGVWATWYIDFEEPRCITYWDTLRDLGCSSAQSGKRRYEARLMNLTHRDDWDAMCSTTPATINGIHFDHPTACEDRAGATGVWDVPDDTCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVM8</accession>
    <name>A0A4Q9PVM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division control protein 14, SIN component-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVM8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012535">
        <property type="entry name" value="Cell_div_Cdc14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34065:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08045">
        <property type="entry name" value="CDC14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="456"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="588" mass="62008" checksum="816B616191409BF4" modified="2019-07-31" version="1" fragment="single">MDPDVDDSNPITAPMHVILQDALDELVSIRTSTTTKGDALVAIEHVLAETSDPRAVGLLEYFNELQDTFQCNVSSRIISWTSVTSGLLDKALHKGSTDDVRRCEVISFSSQLAQGMSIIQGVALIHKPSKQFLGRRYSLEVLLDLLLVSRHLTTPTASSMPTSPIAGVSSASPPKSSDAPLASVILDTLLCILVDSSPALRVFEDLNGVQVVVRILKRAGTPREVRMKCLEFLYFYLLDETTPPELAPDAVVSDMSSSETPTTRSTISDRSNSSLTAAYSAGYSTAPSSRSSSGSSAFSVLSTSTTATSASLLDAPILPKPHTHVDTPAKPALKPKSVIPGLTPSTRNITPPSGGSSASALGRVQSRSKLLMLKNEVDYVPLSPKKPQLSHLGRGPSGLRPKPERGPSNSKLHLSSEVQPAEDIRGNDQGGSSLAATRWTSPNTPHASRASHSHSRGISVSSISSISSISSVESASLRTGQPPTTPGTRRDKLKSNHTEILETPKPASSKVQAHRRAQSLADFSSPSASDLSPLAASRCASTPTGSGAGTEGHRGPKTMAEKKEILGTMLGNVDALVEGVKKAGVWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVY5</accession>
    <name>A0A4Q9PVY5_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_977248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVY5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVY5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050308">
        <property type="term" value="F:sugar-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051806">
        <property type="entry name" value="HAD-like_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481">
        <property type="entry name" value="FRUCTOSE-1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43481:SF2">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="217" mass="22864" checksum="9EA1D652BF07BC1E" modified="2019-07-31" version="1">MSNSDHIRHGDPRAGGSTRSESTANGTADLSNSLADGTLTDSIAAVEAAWGKVANNLGQDPVYVIAATHGKRAVDNLAQFKPHIKVHEMDAKVQAFEESILFFAEAFTKHGPGSREVSPLFSRAATPSLASSSSSSGTSSSGSRVASPRSCSPSPAGYTDLPSLVRCVTNRLALITAEGATYEDEEITGIPEPMIDWRMGALAEAHIRGVAGRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWG0</accession>
    <name>A0A4Q9PWG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_850073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWG0"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="17944" checksum="DDA38C71297107BB" modified="2019-07-31" version="1">MSNNRGNDWNSDPNNFSNTGGPDAGFGGQQQQTGADTSTFGSDQFSGSGGQNQGQGNLDNNLSGGGGGGGFDRAGRGDTLGDQYQTSAGAGDNYGSTGYPGNTTGTDSYGAGNVNQFPGSGAGAQDNQQANQFSRSSGGVGGGGGRGFGDGDDYDQSQYNQGAGTGNERSTGQKIKGECLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXN4</accession>
    <name>A0A4Q9PXN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925384</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXN4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="22693" checksum="BF152625F3C36C23" modified="2019-07-31" version="1">MPHPASGTYRTTDINLATLANTLGIDVQSAGSCNMQLAILLIMDDILSNLDDDNASLRACTFVCRAWCSFAQYHLLRTVVCRPDAPHLSLRELLSFSTSAPDLAAHVLSLKIIGGKSGSTPEIAVEDVTHLLSVLHNVGCLSLERVAPITRGRAQALPTKALPLLTELSTISLCALHHTDTIDSFFQILKNRRGTSPLRVILRFVHSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYD3</accession>
    <name>A0A4Q9PYD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYD3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="193" mass="21283" checksum="62CAA343B0D70EF4" modified="2019-07-31" version="1">MTTKFYPITQPDFAQRCGGFTVTKQDPTPLAVNVTKQPPTTARDERIVPPAEADFIESVLLDTDTRLNLFFSDLDQTLLPLTRTVYKQAVDCGLLHATRDVFGRVVELEHSRPAGDVPLLNGALDEEISKIIGSFPCGDIYIDSRVDWKILNSDGLNLAERGESVATPRPIRPGSEDVPVNVQSTGQALSHHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYG3</accession>
    <name>A0A4Q9PYG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_924245</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYG3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7418" checksum="543554E0CF7E98C3" modified="2019-07-31" version="1">MEPSLRESGESRSGVQTWYRVCLDGRRSLPRATSAWARRRAMWGSDLGSGPCRCNPAGSRWGASHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYI5</accession>
    <name>A0A4Q9PYI5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYI5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8865" checksum="101D720449F24AA3" modified="2019-07-31" version="1">MSECASDGRPWLSNRPNASWPRGGTIRADETIAYSSLSLNLNDVLPHNTPYLSCEPTKSLPTESRSRRNSCPAAYCWLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ26</accession>
    <name>A0A4Q9PZ26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_876534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ26"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZ26"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16015">
        <property type="entry name" value="Promethin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="270" mass="29201" checksum="B44396D884D8505D" modified="2019-07-31" version="1">METVDGPDAKYENDVDEEGEEDLLADYFEKSASAVRQTFGRFEQDVVRPVLDYVSVAFHKRPIRSTFIAFYLALSILPVLSFIGFSVFIVATSIFVALTGAILFASSAISFFGFWLACTLIFFAFVSFNLTLSTLATYLFTQFAFRARTDGARLALASVYADARAQLSLGRARGRKPTSRPLHTYASPAANIIQSSAQTETDEGVRVSANAQGKNEGSDRYDTVIIVDVGEDSHSPSPSPQDTQRSPASTGTTNAAFGEKVPGIPVDGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZE7</accession>
    <name>A0A4Q9PZE7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_924501</name>
        <name evidence="2" type="ORF">BD311DRAFT_766143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143475">
        <property type="protein sequence ID" value="TBU24651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZE7"/>
    <dbReference type="OrthoDB" id="2798132at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="7"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU24651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="139" mass="16330" checksum="3FE55BAFC39BA986" modified="2019-07-31" version="1">METRELVTVAEIEGLQSGEPRVRFGGDKSPWQSATDFLKFDPDRVSGGTFQAIGGVEYRWKTHHGRFQLVRADDPEKKAVAEFHPHRRHLFVFRMSKHAYFEVQPLPEIVEAIDKFIVSYLLVERKRRDSRIRVKLERH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZE9</accession>
    <name>A0A4Q9PZE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_876368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZE9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZE9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="220" mass="22525" checksum="8752D2755F82708E" modified="2019-07-31" version="1">MARYAASTSLALFAALLSLWSATFLSALASPLSPAPTALGGLSQASPQPLVLARGVSAERRQDDGSEPVFPAQPPSCPICQQNFGSIDSCAQAAPVLQNFSMIIFNPGAFIDVIKCACADTFQSAYPQCVDCFIKTNQTSFLDSDSANLPGIVDGMRKICALESTLLGNVSNSDGETTPTSSAAAATATTTANGASSLSSSWSWSAVAVAVLSSFVAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q234</accession>
    <name>A0A4Q9Q234_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosome recycling factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_921611</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q234"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q234"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="entry name" value="Ribosome-recycling factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982:SF3">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME RECYCLING FACTOR PSEUDO 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="RIBOSOME RECYCLING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="Ribosome recycling factor, RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome recycling factor" evidence="5">
        <location>
            <begin position="117"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="273" mass="29585" checksum="0F3ED4398D6F0B88" modified="2019-07-31" version="1" fragment="single">MNAADTAPCLSTMSAVALFVRTRLCTSSALALAQCSACRAAAIRASLATQQSRSYAKPAKKSKSKEDAASHKKGGKGVSTDDLVPASQRIASSADYKNTESKMQGVLEWYRKEVAALETRATGRVTPAVLSPVRVKLPGATDARGVRLEEVATVGVKDGTTLLVTVFEEHTLKYVEQAIYDAKLPSITPQKVDTRTIKIPIPKPTVETRNALYTTASRQAEDVRVQLRKLHQALLKKADINKHSADFSTYQALNDQCMSELEQILAHLKKSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2R5</accession>
    <name>A0A4Q9Q2R5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450 98A3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_946557</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2R5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2R5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="435"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU61425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="526" mass="59213" checksum="033DD33756EC93D6" modified="2019-07-31" version="1">MPVWLWNATVGIILLATTVRWRCKRIAHLPPGPTPFPIIGNILNVPREHLGREFADLTKTFGDVVHLSVLGQSTIVLGSQKAAYDLLDKRSANYSHRPASVMVPLVGYEWLFALMNDGQRWRQHRRAVHPTLTPDIVREYQPIQSKVARRFVRSILRSPQDLALHIRFTFAAIVMEVIYGIEIREAHDKYFKMVERMAEVGEAIVMPGRFPVEAFPALRYLPSWFPGGGFKNFAADAKRDISYIIDHLFETAKTAMVSDTSGSVVSRILGASEDEDAQLEGMCKEVAGTLYVGTCYTLTNATMEAFLLAMALYPQAQEKAQAELDAVVGTERLPEFSDRPSLPYIDALVQELLRWYPVTPIGVPHRVVADDEYNGYVIPGGATIFVNVWAILRDPDVYPDPEDFKPERFLNSRGEFDVGERDPAEILFGFGRRVCPGRHLAQATLFILCACVLAAFKIVRPVDEHGAPKEIKREATDANVISLVVSRSCRLSFIEVHLDRHPKVHRYTMQPRSSKLQQYLGLAQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q311</accession>
    <name>A0A4Q9Q311_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_196241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q311"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10529" checksum="A58445CCA133C0F0" modified="2019-07-31" version="1">MMVRRTRFLPPPLRFCDRVKAMEWMPVATAGTHDLRHRVSCMCARGSYGRRFAPGRPGRVCHGPHVRRRHADVMLSLDCLMRWLSLNAGQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3N8</accession>
    <name>A0A4Q9Q3N8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_779297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q3N8"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="207" mass="23253" checksum="C1EB14BA3CC150F1" modified="2019-07-31" version="1" fragment="single">LTQETDSKLVIQVVTTRLAKDEAEGYIGKKNVDITRAVVAALRSRKAPVSFKWVKGHSGHTRNEGADRLADLGVKKHAPDEVDLAIPADLRLTGAKLQALTQRLAYKAIMNRKEGKLVPRPKTTRNLDMIQAGIEDACQVQVTKQSIWKSLMNSKVITREARRFMWMSIHDAYMIGPNWLKDNMSEEQKSRATCGVCNELESMTHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5G5</accession>
    <name>A0A4Q9Q5G5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_946003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5G5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="165"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="343" mass="37704" checksum="A9C17708015434EB" modified="2019-07-31" version="1">MWWPSVSDSTSPGGTLGVLVLATLIAGILYGITVLQSVQYADKFYNDPSLLKLMVSNRAFETITVISEAHALYTYSVSYSGTLFALVPLPWSLQLDRAFSYAVIYGVQMFYAVRIRQLGRRYWYFPVLTGLLATGAIGTSYTIGDPNVPSWINILSTTSAGLQIGVDVLIAGALYWFSRNRAGNLKKRALVKHTLVSAINRGVISTLLQAMITVSYFALRPRMIWLAFQMANNKVHAMSLLSTLNTRSSVDGVGHDPEIVDARLRYRVERELANSLVLAWVQSDGNSEFQSRTESPPIIPDLGHGLMSSQSSWFAKSEEGGLARYAPSYHARSTTAVESQSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5S4</accession>
    <name>A0A4Q9Q5S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5S4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16979" checksum="E7B37A32A7828EEE" modified="2019-07-31" version="1">MVGPEGELRVPTWSRNIPIFPNEYGKYTHWTVKLMSMTLLVPQVTNPNYTKASTLDWEAIRIEMPAMDGQHGIRVELDSGSSVCLISKCVTDEIRKTWHKEEDIFVKELLIPGGKRSGCCVLLWGSALLSQPLEKRRRLPPTFHTTNRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5W5</accession>
    <name>A0A4Q9Q5W5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1036596</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q5W5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="368"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1482"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1751"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1961"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1096"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2398" mass="269583" checksum="BA6C0A5986AD8D3B" modified="2019-07-31" version="1">MGSDGMQITIPDFHDDDDTFQSTPLFGRAQQASLWGSSSSGLESPTIMTPQATTERLGGSYFHSRGDSVASQDSGQSIQYTTKKAKAPFTHSTQSSVATTSSSPFTKKTSFASLRNAFKSAKFSEPPPLPPLDHQAYPVLKNPFNRSTSSLAQNPPAPQRAQTMNASPPHFGRPATPGSGEGRARTPKQKDHQYARSQHSHSGSLFHASDGGSDVGFSYPFSSSPPPVPPMPNAFGGHIDDGSSYSDAEDKVVLDPRTPSDYALHAIFIRFAASAETHIDEFLRFPVDRDVHLEDYMGPGVDEKFDDILSSLGKVAQRHAKPVVDSIMRWRNSQNEQADPDLIRHHHSQSPSASRAIRMPDVTQMLNERKRLAAVYIMCRALIAVTRSIAKDSLPEQVGHSLEELTFEQFKKYDMKLSMQSSNHRCIAELHAALLGQLSDIRFESVTDRFLTELAPVAAGQVAKDADLKYENIVKGLRNINIKVWPPERFEEGAEFLASLSKSFENAHGNRLKTIFAETLVQILHPIGKTAQAEVNHPEWAKAMEVIYPKAKDMMAKPRYWHVAYPLAVTALCVAPHEFFLRNWYTCFEAGLGKLKEKIFRVPVLNGMLRLLWTYLYRCHEPISTASAKLDTILKHVFPPNRVAVTPHDEHLQPFICIVHFVLSRHFDVGSELCLDLLQERFMNSQTGQASHTLAPERITIATQAILLSLNLIEREEPLPAWPSSADFSSIPSPDDYPSSSTPLPASIASKASWSDFLDRATTCLNLIALGCYQVVGRWSVLDDQWTTSRLGPNYEDVHNHVVRNHPEGSIAYSDQYASHIHVLQVIFQSWPRCLHASLSMEEAFNMLIRSVIHIEPAVGEAARLALQRFMAEPAHASVLLARFSTFLFAPAAIAQESYGFRLPVECTRLLDLWYSFVEQWINEMRQRAFHTWTVEEAEIVVARAEEIELGALFLLAHVKQNAFTTGIKTLRLLKLLMVHMHPEPSTPTSIPPSELFATVQALFEEDAADALFRGLDEILEAEELERLKHWKRSSSSNKLLRLAESEHVLDRALWRDVYPIFIRRCLDSAPSVVTGLREKLVAAAARGTHLMQQLSGVSSRVPSNAPQRTGSSGEGQLLVPQHKDFVYQWWIWVKIICATASVSDSRPPMGGMRDHSRARSDSELGPEQMQTTHDLFWALSKFLDTDFPVIRDTAVSCISSFPANAYSHLLEDLHKLHTRQHYDDPRLKGATAAPMIGKLRRQERFLAAIARIYYLTAHYLQEQRSSGKQAALTYVLQYVRKTHGFLVSAEHRDRWFMQRLRRYFCGTIERVFDALATLKDSDRFIPPNLYLALYTMCEEWCQLGKQSDDVKKRLVYMQTMAAKSYTTAADQADVIQKFQTETRLLSHAAIGAMAAVCQKAFFPPDVDTGSPTDRQVLDFVKPLQAGPTLDRLTAILASFHEPNQKAAKKALRALLSHHRCSPTFLDECLRRAFVTSRELDTSNARFFEVVADAISSGAATTFSFAQVVCLGLSNLCHPLLEIRRQAFNILEMVHEQSAGIISLCQYDAAVGSAAPSTYLYAQRLISDVLAGEHPEQAVKVLTQLAVWIPSVFDNRPERGVLLLLQSLEHWVPNIDLMSDDKTELSRDGRITIYHLMALTLRYSEIYSEQVLVLWMRLVDAPNQSNGQAIIRFLLEQSHKVGSTIFLSCAAKIVACLAQSAIGRQIVEELCSVVEPARMLPSIEHKLAPPSDEDLELWSDLDMLFSEKPRLSLGVAQFALLFLSETALERYWEFQDQLPVLFHALFMHLDHRQPAVQLRCRHMLFQLLRSCLTGYDELSDRSLLRSRPELKAMIKDLEKEVETRLWKEDDNADEAEPKLRWLGNAVLTLVEPLHPRLSEQWGTLALTWGTACSIRPVAFRSLQLYRALMPRIGPTHISMLLGRLANTVADEDHAIQSFNVEIISTLSALASSGDLEPNQFPQLYWCAVACLSTTVEAEFLHSLRLLDTVLTRMDLNDSLTAELLLQYMPVNWNGPMTMQASLLRGMRSSVTSELTLKILQRLTTIEDSRLIDQSEGRVRDLYTLSLPWCLHDMSEDIKDESLSEFALNISRLAEQEERPSIERIMVSFAKGRFRTKDDFLRQSVASLREHYGIDHWTEVITLLMGLVLNKQRWLQIHTMQILKVLFQQRETKNQVDRLGSELLMPLLRLLETDLSSQALDVLDEPMQISGGPAAKHVLRMSLHHHLRANAKEVESVAEIFGIPQESGWCVPHTSELRGTCRANVVAVFDLGKGNLRPSRIDFQPDEELAMLHNPLEDDLGDMVQDLHELSSYFQEVPGAGSVPHRQLEARVAAILAKSTDAVDSVPQTPFVDVFNVGGLSPTYEDSEDSDTDTESDLFEYDSPSFARFMNPNAAHSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7P0</accession>
    <name>A0A4Q9Q7P0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_841683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7P0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="2">
        <location>
            <begin position="9"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="274" mass="28689" checksum="DF381D77DFDEF02F" modified="2019-07-31" version="1">MDISFVSTDPFNTEVIDSATGNLLYDIETPFKLLRKRTTTIWTARKKVVGLYERSWGHNKVAYLGETRKVAEWLPKESPMSSSRTFVAPNQKVYTWTLASGGTFKLFDAATQAAVAETRYTSAGTRSRKPHISINIGAELVPFLDTVLLAFLICEDERRDIDQQATDAGPPLVQDTGFNGHVASDTGLEASVVANAGLSDVNVVEQTEAHVDVGTSAVFDAGAHGGGGAGADSGQESSLGDGGGNDGGVMANAADHGGAWGDTGGYGGDAGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7R1</accession>
    <name>A0A4Q9Q7R1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_581674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7R1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="17370" checksum="FCA5443A30444428" modified="2019-07-31" version="1">MQRQFPRISTVQKGITAVLLSIREASMSEQFSICPEHLPWRCRRHNVDIPMDRSSRFSCALDPASFLRSMLLGPAPELTPAPLQARGLAITYNVQPQLFPLSPRGNCLPVLADSPAYVKIRVYQRTTWDAPHRGASFVRVRKFVAYVIQFMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q837</accession>
    <name>A0A4Q9Q837_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_915728</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q837"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q837"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12400">
        <property type="entry name" value="RRM_Nop6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034228">
        <property type="entry name" value="Nop6_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF51">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="148"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="278"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37596" checksum="E4FE138243DAD051" modified="2019-07-31" version="1">MSSAPKLTKKQKKALAFRDRGKGKGKGKAKSFDDLDRDIPVEEDQDRADAALLLADEGASSEAEAGPPKDVVKGSAKVEGRSGAEDGREKGKGKKRKRDEGIVEVLEKETECAAPKDKAKKKRKGADGDAVDVGEDAEGAGKTRKPKFILFVGNLKYTTTKEAVEQHFSKCDPPPTVRLMTPKPSATSKPSVKSKGFAFVEFKHRNALQQGLKLHQSELEGRKINVELTAGGGGNSEHRLEKVKQRNKGLHDQRKKQLLTRRSGKKNAEGEDEGAEGAGEREEVQLERPQRYSATSGVEQVPLKQRTWSIPEETDEAPAGKKRGNKKGKKRPPKPLGTGVNAIPVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q846</accession>
    <name>A0A4Q9Q846_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_807970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q846"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5444" checksum="B64BC195114E328F" modified="2019-07-31" version="1" fragment="single">QPSNVQCATQTSSSDCSYPNCACSSEPPKNQANCGSNSCSCGSSCACKPGECKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAE5</accession>
    <name>A0A4Q9QAE5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FK506-binding protein</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_914955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAE5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAE5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023566">
        <property type="entry name" value="PPIase_Fpr3/Fpr4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001473">
        <property type="entry name" value="FK506-bp_FPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="126"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="371" mass="40616" checksum="1E88AE3300C01318" modified="2019-07-31" version="1">MAIAVGVWSLEVPPGDPIVINPPADLRITNVALGDEIKDEKSRTTVKLVYRTPGVPSDSDDEDDDEDDDRDDDKSLGPDDRDPLTTTVLCSLTLGKIEQATVDVVLTEDAEYIIELVGKNTVHLTGNYIDQRPPDQDPFSDEESEDDFDLRDVSSDVEVDPNELDIPTDGSERFEEIVDEEPSTASKKRRRESDAMETEEPAEKPSKAQKKKLKKLKNANGEAVAAPSPEKSDKKEDEKTKSDDKEKKEKGDKKKDKVGEVKTIQGGVQVVDSKVGTGPKAKAGNVVSLRYIGKLQNGKVFDQNTKGEPFKFRLGRGEVIKGWDVGVAGMQVGGERILTIPPAMAYGKKGDKTIPANSTLIFEVKVLSIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAV9</accession>
    <name>A0A4Q9QAV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_840616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAV9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAV9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU64211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="226" mass="24512" checksum="B3B39C86C52A707B" modified="2019-07-31" version="1">MSLLRLLPTLRTPPLQRTCVAALSYCAPRLAEAPKQDANVLMQFDDLLKDDDPSTRSETATTPPPVEEDLPPPPPPNSFPRNPSPANPITAAKQDGKVSSKGAVRPVYNVSVKSSRNNTIITFAKPDGNQLVTLTGGKLGFKKSNRNGYEAGYQCAVGIIGAMEAEMDRVDFDWHLYLKGFGQGRDAMLTAITTAVGAKVKPKLKRVTDRTPLKIGGTRGQKTRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBW4</accession>
    <name>A0A4Q9QBW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_805017</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBW4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBW4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="211"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU65169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="686" mass="73924" checksum="CDD7263177BB818A" modified="2019-07-31" version="1">MLFDHTKLEDSEGPAGEAALAYKESRDVQGARPTSRRRRLYIWLGVGIAAIVIIVLAVVLPVVLTKSHSGHSGNKPGGGSGSNPESPTGAVTGGDGSTVVMSDGTSFTYTNKFGGFWVDDPKDPFNNSARAQSFTKSLAEPWDYSTDQIRGVNLGGWLVLEPFIVPSLFEKYQNVTPTPALPTGQAVDEWSLSIAMLNDTTEGGGIGQIEDHYKTFITEQDFAAIAGAGLNWVRLPVPYWAIETWPGEPFLANKAWDYVLLAIQWARKYGLRMYLELHTVPGSQNGYNHSGRLGPINFLNGYMGIANAQRTMDYVRFLTEFFSQEGYSDVVQIFGPINEPLLGIIGRDQLTRFYLQAHDIIRNITGIGKGPYIAIHDGFQSDASWKDFLPGSDRIMLDTHPYVAFGGDFNHPLDYWPQVGCVAYTNNQSQSDFGITISGEFSGAINNCGKWVLNVGQNSTLTDCPTWDDWQTWTDDMKTGIKNFVMSQMNSMALPGYFYWTWKVGNSSVTGKVEAPFWSYSLGLQNGWIPDDPRSALGLCVADGFPQNVPWDGQYQPWQTGGSGAGTIAATALASFSQYPPPAISNVNGADPAQLPMYTPTNAPITLPPPTFTGASVTAGDGWADPQDTSSKMTEIAGCVYPNVWGPAPDSTQVVCGGSTVAVPAGTAPAAATTTSAPAAATTAPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCK3</accession>
    <name>A0A4Q9QCK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_11348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCK3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCK3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15864" checksum="766AB3FD7814A47C" modified="2019-07-31" version="1">MEGVHQQRSNAADRAYATTGFALPAPTTRPGPFSRTTTMVAPVASPTLIPRSPVFPRLLPLPPRPHPIPPAPSFQRRERFINYRDIWREMEELSDEEDAVEDQNTDIKTRGYNFLIPIGRTWTQHEEKNDVSTPSARQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCW6</accession>
    <name>A0A4Q9QCW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_943167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16494">
        <property type="entry name" value="RING-CH-C4HC3_ZSWM2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="Znf_RING"/>
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        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
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        <property type="entry name" value="Zswim2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540:SF0">
        <property type="entry name" value="PHD FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21540">
        <property type="entry name" value="RING FINGER AND SWIM DOMAIN-CONTAINING PROTEIN 2"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04434">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <location>
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            <end position="132"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
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            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
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    </evidence>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU65607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="308" mass="34419" checksum="E14071E85C337019" modified="2019-07-31" version="1">MLPPSNYSYAASHAAAGAGSASNPIHIDSPPKPKRARKTKVPNAPVPEKRGAMFKKVCPKNIIERAVRVRDQRFYMIDRRRQGNELREEFSVLGSTGNVYNVVIDKKPSCTCPDALKGNHCKHILFIFLKVLQVSQKSGHWYQKALLTSELEDIFARAPRDPAAVAHERIQKAYAQATGKNVASGSQKIKRRLPGKEDMCPVCFEDMEGVDEKTLTFCDECGNGLHKDCFQQWMNTQINQGKPVTCMFCRAKWNVPAVAGQGRAGRAQISEGYLNLSAAAGINPVRDTSSYYHGPTRGRRYYGYQDYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD90</accession>
    <name>A0A4Q9QD90_9APHY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BD310DRAFT_864774</name>
        <name evidence="2" type="ORF">BD311DRAFT_647049</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <end position="142"/>
        </location>
    </feature>
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            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
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        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU35898.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU65747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="418" mass="43608" checksum="95D7584E7CF024FD" modified="2019-07-31" version="1">MPNAPPQPVAAPARHPAPAPAPRDADAAPSFDALLRHIRQEVARVFQLPPDSRAKEDQAILSLAHRAFARYGAADKAALPPPLKQVDAYLKGPNQNESLSHYLYARRADLALDDIDSSDGDDKDGVGEPSPDDDRDSDEDAIGSEHPKSPSLGPTASLAGTAGNTTVSSPEPRSTVSAPAQQKADQKKSASASASASAANGVDHTFTGDDRCTNCIMRNNPTCIVNSSRQRCDSCFMKRHRCSKVLTPPTRPSRETKSASVKGKGPGDAPADANGDSASARAPKRKRTATEEDTKRNESAAKRPARPQRPAAAAASSAAGTSASASAPVQRPPAPKKPPMQNGNAAASSSNAQNLSLAALAASASRAARAPTNTVPAHNSRHQYYQEKLQVISGILGMVQTAVKELQDQVNADAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDH5</accession>
    <name>A0A4Q9QDH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_803157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9QDH5"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="301" mass="33317" checksum="31FDF1491A2A5902" modified="2019-07-31" version="1">MSYNDPYAHGQYGQQQYQDTPFNPYEVQQQHGYTEPAREYAEPTYDYTGHAKETPRSGFDDDVVPAPIGEKTPGNVRRWRKDYQGNLWTKGSRLGCFGRFFCCTLMIFLFLLISIVLSLALWLRPPNIIVGQPTVDVNSFAINSSSISIALPVDIRYFVNNPNYFTVELYKLDATVIYPINNTQIGSGHMTNIQFKDHTQTNFTFPVTIDYEAASDPNGAVITDLAKHCGIDPSTAASDITVTIDIKVGVKVMLVPFTTTITQKASFACPLGNDASHVTQGLLKSLGINIDDLGALAGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE61</accession>
    <name>A0A4Q9QE61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NYN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_912822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905762">
        <property type="term" value="F:CCR4-NOT complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10910">
        <property type="entry name" value="PIN_limkain_b1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024768">
        <property type="entry name" value="Marf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021139">
        <property type="entry name" value="NYN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379">
        <property type="entry name" value="LIMKAIN B LKAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14379:SF3">
        <property type="entry name" value="MEIOSIS REGULATOR AND MRNA STABILITY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01936">
        <property type="entry name" value="NYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NYN" evidence="2">
        <location>
            <begin position="9"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU66123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="549" mass="59008" checksum="DD4721A41DEC5A37" modified="2019-07-31" version="1">MSHSFDEHVAIFWDYENCAPPTSTPGYDVVSNIRQVAHEYGSVKLFKAYLELSEQSSSKSIGLRSELQSCGVSLTDCPHNGRKDVADKMMIVDMLTYAIDNPAPATIVLISGDRDFVYAVSVLRLRRYRVVLVAPNCAHASLKSQASAVLNWETDIMGKTNPRPQTLDAPNSCSDDAPQRSPRRTSFGSQLPHFTAKHARRPSFKTNTPITPVTPDTGGGQGDSFFGGRHLRNPSIVTTVECFVADTHLHGRMESISTQPPIPDIVDFIQDIKGAELRLPAPDDEPSAYVSHILQTSATLLAPVSAANPTSAPPSSRDSTNGAEPASAPPDRLNAPPLIAPEPIAFPRLAFEEPILRPATVEPLSRVPSESSQSSVSGSAVSSSSGDLLRTPDYVLAEALDVTPPTPALDVDESPITPIADPVQALPPTAQEEPTPHSPPVVVVEITAPVPPPVSFAPNAVPSSIPHYFHPLVKALEESRMSGSPRPLRSWVGLKIPRGIYTQANVPKFKQYAAAAEQAGLVELGGVQSSAWISLRPEWYGKIPVHPFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEA3</accession>
    <name>A0A4Q9QEA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_838923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEA3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="461"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="59163" checksum="358A577CE674080E" modified="2019-07-31" version="1">MSNDVPSSEASQAVFQSNSLSDLECPPTYSTDGLLVPMAPAQNRRYARIAFATPAYIKIPRGLHSALLSPEPQYLGVGWVAHFNPEGTQYYVNATKRLVTDDPIDHPDIWAKISAWILRLDTLIETDGMTLPDDYEIFLTVATDDDGCKYYFVDHTTQTVFWIEEIDPERHELELPPVCSVAHLRFALQEQYWVHNEYFPHRQVPQRLRTELVDIFRQGRADQLTSENSTFPYSAQQCKHYLQVIDVDTECNEYMTWTLARLWGTISRHKFSTFFGEDYAKISREQKRYDRPAKQRTLAVKLCSALLFNMPRERSAQMDLLSLDDLTYVMHWRDFAIDLLHGWRESSYLAVGLALIGTVSTVQRTNPISAAMGSISIVLSLSGLATSAVLLQWYAGADKFTAGTVANHLARVQLPRLGYEPIAQAYCLPRALVAWSMMFLAAHILSAVVDIYGLIIRSPAILLALLVAGGLLHVNSILRSAFDSPVVLDHPSDVRMLDAFKGVRSFLWHLKQALPKAFHIPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFX9</accession>
    <name>A0A4Q9QFX9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diaminohydroxyphosphoribosylamino-pyrimidine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_837034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFX9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFX9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF162">
        <property type="entry name" value="RIBOFLAVIN BIOSYNTHESIS PROTEIN PYRD, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17974" checksum="50F75E2C981DC13D" modified="2019-07-31" version="1">MEWLRLALEEARKCTATPTAFCVGCVLTATHPPESDKPVILARGYSRELPGNTHAEANALAKARQLSENQLLEMFPGASSPISIDAILCHADVYTTMEPCSIRTSGLAPCADALIAAGIKRCFIGVGEPDDFVNCEGAQKLQDAGVEVIWLKGLEKECLEVARMGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4J4</accession>
    <name>A0A4V2K4J4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_930473</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4J4"/>
    <dbReference type="STRING" id="114155.A0A4V2K4J4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="46657" checksum="6164940E37D8A70B" modified="2019-07-31" version="1">MSDYEEDDWDELVEEEVEHDPNRFDLGTCLNAPKVKFYTTKELHGLIHEGVIDLNPPYQREIVWPEAKQMKLLDSLYRNYYVPPVVFAVYTDDEGEKVKCCVDGKQRLTSIQRFFDGQIAYKHHETGKSWWYTRSNARKKSRLEIPDKFKEIFAQKTITCVEYEGLPHLIERDIFQRVQLGVALTAAEKLQAISSPWTEWIGELQSRYVYLEDSLTQNINVAIKRGQDFQLIAGLVYCCDMYPEHSQPLSKNLDKWLSRMDPPKEDFKDLIRSLLSRFWHIADDSRLNFAFQDIQKRVAPAEFVFTGVILYVLRDLPAQDQAQAIYQLRTDIRKKHPDIRLRTDIIRDLWVLVEAAAEGAERKGKQGKKKGRRIKDDEDENMDYDEEYPPRKQRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5L2</accession>
    <name>A0A4V2K5L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_820763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5L2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13516" checksum="19EAD75B0C58A17D" modified="2019-07-31" version="1">MQGNHGQSLTQSGLRPAAISGPPQGQQHSHIPQPGGSAPNALSASQQAHAWDLHAEATSKARQGGYQQVHRAPQDTAHQLRAFSTRLTATLTANLQPDPALRGLRLCPTHNTLPILRRNTTLTTTGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6P5</accession>
    <name>A0A4V2K6P5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_182733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6P5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="379" mass="42063" checksum="F1B7AAAEE78BBDAE" modified="2019-07-31" version="1">MAQMRFLHAPTGTFSETRYTVDQLKADGIPYACLSHVWSKPGDSGYPECSYQDVLKNRGRRLSSKIQRFCDVVKGNGIELAWADSCCINQDDLAEVQPAVNSMFTWYRNATLCVVFLHDVDDYPGHLTAQWATQFCDSGWFTRCWTLQELLGPDSVIFYSRNWRPIMDKATLSNSGELAALVECATGIPPSVLEDPRSLANISVAQKISWGALRRATKPEDASYSLAGLLGVSLNVRYGITVEEAFQLLLSQVLQRIPDHTVLLWGHPCQAQYPFTPPACHDDPHSLQDVAPLQTHLLPGCPADFCMSPRFISFHRAQPFLDAAGIDRGRATDQIFVIRRTADGVHAKLLLSLPVPTSCHHFPTRIALLGCYVNGPDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6R3</accession>
    <name>A0A4V2K6R3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_167605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145220">
        <property type="protein sequence ID" value="TBU53243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6R3"/>
    <dbReference type="STRING" id="114155.A0A4V2K6R3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="23925" checksum="174076ACA81D571C" modified="2019-07-31" version="1">MKSALRKIKSKLCKRKHIKHFSIPFADEARVAPIDAHTEVVPEASNKDAALTTSSAEDVAQIRTAVDDGRTALAPLSSPNTIVAKGATAIEATPEAVESAYELWKPVLEKVEIFASLVESIGDLHPYAKIASTVLLSVVKPVIDQDKRDNAMADLLKAMDDLYEFVNKTGRFTDLDEYRKRLLKDMSKKTQECAEFIQDEARFTNFCEDVIAEALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6V9</accession>
    <name>A0A4V2K6V9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,4-beta-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_133269</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;4)-beta-D-mannosidic linkages in mannans, galactomannans and glucomannans.</text>
            <dbReference type="EC" id="3.2.1.78"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.78" evidence="4"/>
    <dbReference type="EMBL" id="ML145206">
        <property type="protein sequence ID" value="TBU53753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6V9"/>
    <dbReference type="STRING" id="114155.A0A4V2K6V9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016985">
        <property type="term" value="F:mannan endo-1,4-beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046355">
        <property type="term" value="P:mannan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045053">
        <property type="entry name" value="MAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31451:SF39">
        <property type="entry name" value="MANNAN ENDO-1,4-BETA-MANNOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="10">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU53753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="371" mass="40142" checksum="A9A775613CBBC24B" modified="2019-07-31" version="1">MRFSAALLGVLALPALVCAAATASPANFAGSNLYYAAGLSSSQRATLLKGLQSANMKVLRVWIGAQSGSQKGTSIPAFPDVEPSTVCNGDTSCYNPQILNMLDDLMVDAKSYGVKLLITMHSFNALEANDVYGQRWGTGYFYEQADAQAAFDKRLQYIVNHVHKTLGKPWKELSDYIIGFEAENEAMIGKGEAYIQAHTSWQCDRAATIKSALGSNSGILVFTGGESWVSESVQSAWLQCSGIDVISLHAYGVGDFATSNLQTYVNMAKSAGKRMIMEEWGACYFSTENNNCPQGDVLDTDTRNSNIKTWAAQVNAAGLSWLYWQVLPNNDPHEGYDYEIGIGEASWGTLQAAAKNAYSTTGAFDFSGYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K878</accession>
    <name>A0A4V2K878_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_977001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K878"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="254"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="445"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="826"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="950" mass="107700" checksum="36897C850EA29093" modified="2019-07-31" version="1">MEPQVFPSSSKDKPHSSPVQFAQDKHHDWNREPGIVQLPNAPFDRLEMVRDLHGKVVWLSLKDFVNKLLPIPRRLLFNKFPPEQMSKINAALEGVIQNYKQRAQENKCLPEDQLATDFTDVINRDVLAHSAGDISNMDQTSVTVPIIPADSSTHLASDADEALESTTRSSHPIQHTDTIDTVPHYVVRLSPHKWDLSDPARNKSDAALFMKDVELEEGRPNWQHQRAFFEFKQEGTQNDPFEDAQKRDVEVLADKRQKVRGQLISYADRVFLYQHRTAAFSLFVIGKEFRVMRWDRSGVFVSEKVDYLLRTDALVEVLLALIVMDDEAQGFDTSATLLQKDSDDYRLMDTLADVNISFHLPVVSSEEGTPLPKNLASVPSQPLPTNTNTVMNDPSPGLAAQAEDSDSEETVTLKIPNSDSFVFDYVLDYFRKSVTDWPRYNLTINDEEFLVGKPLYHTRGLVGRGTRGYVAYRKRTRTFVFLKDAWRPFYENVVSEGEILDKLNKDGVCNIPTLLTAQLFDHETRVSRYCYKEDLRTNEERKMQAHEGPSDGPHGVKRTQSGMQEELKSYVRHYGHHRLALKEVCLPITAFRSSRQLVSVVGDAVEAHYEATTKSMMIHRDISSGNILILPKFVIPDDGDGNTTLRIRWRGILADWELSKPLQDVGARQPERTGTWRYMSVASLLDAFHIVGTADEIESFFNVVLHNAIRYCSHNVELYVSSFIDNYFVRFEQLPDGTIQCPGAKVNAIKNTGEIRVSNNTRVEFGVNGRPNKALNDLITTLLRWFKARYDVEEYEDSLRSQETSTSATDAASESRPPPAQRQRVDSSASKTGSPFQGTTFREDSAVSGLVKPSTETYKRAARLHDHHAVRGLFWEILHSEDETDWPQDEVLQDHLKILRPLEPVPEETTNGSTSRASANSVPNLQPVYYKTTAKRAATASGVPKPWRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8H1</accession>
    <name>A0A4V2K8H1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_816181</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NST1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V2K8H1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34660">
        <property type="entry name" value="MYB-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34660:SF3">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0346">Stress response</keyword>
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        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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    </feature>
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        </location>
    </feature>
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        </location>
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            <begin position="1148"/>
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        </location>
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            <begin position="1"/>
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        </location>
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        </location>
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        </location>
    </feature>
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            <begin position="61"/>
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        </location>
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            <begin position="88"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
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            <begin position="330"/>
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        </location>
    </feature>
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            <begin position="380"/>
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        </location>
    </feature>
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            <begin position="417"/>
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            <dbReference type="ARBA" id="ARBA00004496"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00020733"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1338" mass="145862" checksum="C649DB20576573E2" modified="2019-07-31" version="1">MTTAKAKRSAARPPPARVTRPATPPAPAPAAPSTNGKKNKKKKKGKGKGVERNAPVPGSYDADEYEDEEDEDDETALPPLEPMSPAHSHPHTHSHLHAHRTVSQRTGLSPELASVHVSTTASLSASLAAHLKPTTAAEAELLATADHLARSMEGAEGGLVNDEYWASFPDHLRNFVRHTYSQLSSAGNADSALKTQAMYAIAQQMHSGANRDGGGGRYPPGAYPGMPFDPAIFADPQFALAMEQAAAANGALQADGGTLGAANVVLYPEEQEYGEDEYYSEDEVDDLDDELGGERRSQAAAHFTLSFEDPLGRSPAGLTAAAAEDGYGGPKKKNRKKKKKGEDRASAGDPAGERPESEEEGGAVTNGGRPVSATNRMPAARPPPAAATNPPPSSRAAGKKPMAYTPAPAQDPPPPSRRAASKAPISSHQYGHNHTHHHPSPPSSNASAPHKPRPPASGQQPQKNSKIWSTSTTEERERIKEFWLGLGEEERRNLVKIEKEAVLKKMKEQQKHSCSCAVCGRKRNAIEEELEVLYDAYYEELEQYANYQQRYISSGGTLPPPQGPGPFPGSVELDKNGAVISPQPPDAHRGKAVIANGRKPVKHAESEFEDDGDDDYPDEDGYEDEEEDEEEEEDEEDEEDDADPEDEDEVKQDRQPTAPRRRAVNGTKVNGRDGLGNFGNNLTVTGKYRNILTVADDLLKNDGQKFLEMMEQLAERRMQREEEAAVDIEEDSEDEDDEGDEDDEEDDEDDEDDEEDEEIMTEEQKMEEGKRMFSIFAARMFEQRVLQAYREKVAQERQLQLLRELEDEDKLSKEREARKQSQNQKKKDKKRQQKLAKEEERAAKAAEKAAEEAAQRAKQAALEEEQRKRREEERAKREAQRKAQEEERARKEEERRKRLAEEREREAERERKKREREEKAKAERREREERERKAREEREAKLAAERAAEKARREQQEKEERERRLAKEKEEKEKAEREKAEKEKAEREARERAIQQQQQRAAAARNNARAPTSPRNAVPSGSQPSPSRPTSQKKILNKPQQPPAPTPPVLQPLRPQPPQPRAPMVGASQPTTPIAPQMPPHIPPLTPVFPPSVGGVGVIPPALSPRVPFTPGPFVGGVSMVPGPSMPPGPPPPLAPSAVPRGFGNGNPFDNGFGRGLTPAPIAPPNRAVQNPLASPTQLNLAPGHPNGRTPGPDPGPITRPTIAPIARPTGDASGSGSTSPTRRSPSPKGVLGSAALLADDDEVLSTPATRRAVPAGAVGQGWGPATSTSPRGSVSSPWGPPGAHSGFPSRAPAPGPPGPIGTNLWGSPPNPDWHPTPGFFGAPFAPHNPSTAPHTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K911</accession>
    <name>A0A4V2K911_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K911"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="74"/>
            <end position="239"/>
        </location>
    </feature>
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            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
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            <begin position="139"/>
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            <begin position="265"/>
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            <begin position="326"/>
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            <begin position="410"/>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU62088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="434" mass="47802" checksum="ED381527601C0BB0" modified="2019-07-31" version="1">MNCPANTTVATRHIFALAAHCSQDWKIAKCPLALMFDLIEAGARLVLIGIASAVLAIAGFLLSVLAHVKEVTSGRSLRNISPDDAPATAESTSPSRERDSGVPSPRTSRTHRTPSKPSDSGPRHRDLSRGRHASRREQSPTTLQSSSSAKEAPGSKKESEQRVTSRKPRLRRPICQTLPDAAPVASPVRTSPDTTRIVEITTTLPPLRPTRAFSDISSNQSSELSAESPVPEEHSPLPGRQVLQKLKERHSYLRERCLVRAQSMPVPRTRTTSRPARRTDPYQAPYFFPTPMSPEAGTYLQEVVKERHGEYPQPVEPVAESSTIDPNAALASSPSSPTREESAKPPQPTPPPSPPARSTAREPAAEAEHRQRRQRWSWHMPHLPSHHQSNERGRSVEGARQDKEILSKLKFGHHRRRHGIGSDDVRSARSPKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K913</accession>
    <name>A0A4V2K913_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein CPL1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_811808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K913"/>
    <dbReference type="STRING" id="114155.A0A4V2K913"/>
    <dbReference type="OMA" id="DAPACIR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein CPL1-like" evidence="1">
        <location>
            <begin position="140"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23340" checksum="98A0288148935C41" modified="2019-07-31" version="1">MCRRSTLPAKQRRLKAFRIWFVCRSQISLCSTNTFYHHQLNLSADHKTCYYPDHAEPICTPGAPCNFKCKDGFFPQPPLWPIECVCEWPFQVCNGICGLYKACPSGKPWRRENLRKRAACEPGMTACGIYGHTNVLGNAWECLDTATDLESCGGCATPLDAFSPRGVDCTAIPGVADVACQAGACAVKRCAPGYEVSADGTFCLTSNPLLEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K965</accession>
    <name>A0A4V2K965_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CyP450 monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_945571</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K965"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14 15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU62678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="518" mass="57633" checksum="5F646DE2D520E779" modified="2019-07-31" version="1">MLTSVGDAVPSPGSLLLVMLVLAVLWTRRRPAVPLLPLPPGPHSLPLIGNLLDMPTKDMAPTFLEMSQEHGDIVSLNVLGGTTVVLGSYDAAVALLESRSAHTSDRPRLVMAEIAGVMWEFAVKRYAPTWRSYRRTFHRFFHRGAVQEYYSIHLRECKKLLSALLDAPEDFLAHTHRVIGGSVMNTIYGIDVTGDHNKYVAIAEKGARIFSEITAPGRFIVELLPWLAHIPTWFPGAHFKRIARVWKEDILAVRNVAFDAVVESMAQGRARPCMTHSLMEHSGIGGEANISSCDEEHYRDVTGVAYTYALMAAFFLALAKFPETQRRAQAELDAVVGQDRLPDFSDRDSLPYVNAILKECVRWHSILPLGLPHATTHEEIYDGYRIPAGSVLVPNAWAMAQDPVAYPNPERFMPERFLKNGQLDPDVRDPFKFQFGFGRRMCPGRHFALDSAFLMIASILHVFTIEPPVNDDGSVAIVDPRIPFDSALSRPEPFACRIVPRSLAAEALIRAPSLDNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9E4</accession>
    <name>A0A4V2K9E4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amp dependent CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_973635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9E4"/>
    <dbReference type="STRING" id="114155.A0A4V2K9E4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="55"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="464"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="579" mass="63467" checksum="9BE1DE9ADA679443" modified="2019-07-31" version="1">MPEIHADGEPLPVIPDNVTIPQFILDVHHPARPVLTKAQPWCIDELSGREVFSDELRARTFGLANALKLRWHIGDNDVVCIFGPNHIDYPVAIWAVHRLGAIVSGANPAYTAEELEYQLGVTKARVLISHAGSLPVALAAAHKAGVPFDRVVVFDEVPGAKNVTVHQLVDEGLSQPQAFIEPRLAPGEGRKKLAFLSFSSGTTGRPKAVMIPHYAVLANVIQIAHYVGANDKKRTNELQRYPPGSKVLALLPFYHIYGLVVVLHFHLFVGTTLVVPQKFDFERMLDSIQRFRVTHLCLVPPMVVLLCKHPAVKKYDLSSVRMLMSGAAPLSSELTNQLAALLPDCWIGQAYGMTETCTAVTFPPNDRRLGSPGSGGVLLPGCVARVVKPDGSLAGIGERGELVITGPSITLGYLNNAEATAETFLDGWVRTGDEVYFNERKEIFVVDRIKELIKVRGFQVPPAELEGHLLGHPDVGDVCVVGVPDEYSGELPLAFVVPSANALARIKQDRLVEQRTKDAIIKHVAEHKVNYKHLAAVEFIDAIPKNPSGKLLRRFLRDRARKLKESGRLVLPTRGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MCC9</accession>
    <name>A0A4Q9MCC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_853943</name>
        <name evidence="9" type="ORF">BD311DRAFT_790801</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CWC22 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143472">
        <property type="protein sequence ID" value="TBU24829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MCC9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MCC9"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="8">
        <location>
            <begin position="424"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="631"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="642"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="688"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="766"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="786"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU24829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU57086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="820" mass="94782" checksum="D0926326561AFA15" modified="2019-07-31" version="1">MATAATMVPTSPPDGLQKRKRSRSPEHSEQPPSSRRRSISPPPSRLLDVKVSDVDPARRAERERQLAARLAEKELEKLEKEKNGKKQPEFDAAAEFAKLTSTRSGGVYLPPARLRAMQEEAAKDKASAEYQRITWDALRKSITGIVNRVNVGNIKHVVPELFQENLIRGRGLFARSIMKAQAASLPFTPVFAALVAIINTKLPQVGELVLTRLISQFRRAFKRNDKIVCHSTTTFIAHLVNQGVAHEIIPLQILFLLLERPTDDSIEIAVGFMREVGAFLAENSPKANATVYERFRAVLNEGAISHRVQYMIEVLMQVRKDKYKDNPIIPEGLDLVEEDEQITHQIQLEDELQVQEGLNIFKFDPNYLENEEKYKQIKAEILGEGSSDEEESGSEESESDEEEDEEAVAEKQGIEDRTQTNLINLRRVIYLTIMNALNYEEAVHKLLKVQIKEGQEIELAKMIIECCSQERSYSTFYGLIGERFCRLNRVWFDCFEQAFREYYETIHRYETNRLRNIARFFGHLLASDAVSWNVLDCIKLTEDDTTSSSRIFIKILFNEVSESMGLKTVAERFKDPEVKMACRGMFPMDNPKDTRFSINYFTSIGLGVVTEEMREHLKNAPRLIMEQRRAMLEAESSSSDSDSSDTDSDSDSDSDSDTDSASASDDSDDPRRSDRRRRSPSPYRKDRRRDDSHSPPRRDRKDSPSPPPRRDDRDRDRFGSRRDSPPRRRDYSPDRRDRDSPRRRRDYTPDRRRARSPPDSVSPPPRARDDRDRRDRSRSYSPPRRGGKDYDRRRDDSRERGHDRDRRRRSVSRDKYTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MCD5</accession>
    <name>A0A4Q9MCD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_826935</name>
        <name evidence="15" type="ORF">BD311DRAFT_670716</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143470">
        <property type="protein sequence ID" value="TBU24950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MCD5"/>
    <dbReference type="STRING" id="114155.A0A4Q9MCD5"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU24950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU54969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9826" checksum="DDD05A973D879178" modified="2019-07-31" version="1" fragment="single">DLSRKLREDDVYHAFHLEKDSIVIVNIWSILHDETIYPRPEIFESERFLMDDGFDPDILDPQDVAFGYGRRICPGRYMAYATM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MDG7</accession>
    <name>A0A4Q9MDG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_831661</name>
        <name evidence="1" type="ORF">BD311DRAFT_670052</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143464">
        <property type="protein sequence ID" value="TBU25259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145240">
        <property type="protein sequence ID" value="TBU52697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MDG7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MDG7"/>
    <dbReference type="OMA" id="KASENWQ"/>
    <dbReference type="OrthoDB" id="3133167at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU25259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8152" checksum="DA07C940CD17AD37" modified="2019-07-31" version="1" fragment="single">MASITQYSQHPFFTHLVALLSVYELGPALPTPIPKYDGPTDWQIESILRSLGAMARRMYTAEEALNAIRDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MHQ8</accession>
    <name>A0A4Q9MHQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_923542</name>
        <name evidence="9" type="ORF">BD311DRAFT_764623</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143461">
        <property type="protein sequence ID" value="TBU25471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MHQ8"/>
    <dbReference type="OrthoDB" id="2017365at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="130"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU25471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20901" checksum="29FD3631610C727E" modified="2019-07-31" version="1">MDTTDTTRLPQAGWIPPYFAHSPAVTPLSNIGIGPDTQAIADYRQPMTTEYVIGCIGVGPYVALNSKCYTNLMSHISTIREHMDAIMAEINYATSPDGPYGPIAGTEMTYQAHAEPTVAPGNPRKRVRAACTNCHSARKTCGESRPCARCYEKGMLCENRPRKKPRAKIDQRSVPGDVGWSEPNLCSVAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N4H1</accession>
    <name>A0A4Q9N4H1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_913144</name>
        <name evidence="8" type="ORF">BD311DRAFT_745140</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N4H1"/>
    <dbReference type="STRING" id="114155.A0A4Q9N4H1"/>
    <dbReference type="OMA" id="GTNDEAC"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHCH" evidence="7">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU34887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11383" checksum="D6CC1C7CC1FB95DF" modified="2019-07-31" version="1">MSFGRPPSLSGGFSVSPPDRGSFPLDHYGECKQYMQGYLDCLRKNTNNSTPCRHLNKEYLECRMARGLMDRDEWKNLGLGNVGASDSNTVAKDNPKDRPNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N5H1</accession>
    <name>A0A4Q9N5H1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase II transcription factor SIII subunit A-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_863867</name>
        <name evidence="2" type="ORF">BD311DRAFT_646926</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N5H1"/>
    <dbReference type="STRING" id="114155.A0A4Q9N5H1"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU35485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="331" mass="36365" checksum="8FBDD256C5160929" modified="2019-07-31" version="1">MSYDIDSGGRRIPTLVQYCQRVASANVESICSLGEGWRNDLIRPVLESCTPETLQRFEDADPYIANDTQDIWKRLFLKEFPIAAHQYESNALEEPESWRDELFALRDREHAKLNALSNRLKASRQEEEERKRESAIKLTDKVPPAKRSRPWGAPSQPKTLFQKTRSEASRLSKGVLGSRITRPAFQTRRIVPNTASAKPPPPSRTASSVKAPSSAQPSGSRVVVRSVPVVHRPPPPSKQASPMLTESASAIPTTSDVCSIPASPPPTASSPPPPSSPPETLWSPLPQPQTQSPEARSPPARAPGKKNPGASLFMPKHRAYSQLPRGVQSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NE61</accession>
    <name>A0A4Q9NE61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1039872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NE61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="61"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="623" mass="68706" checksum="078D7CB8277E4D9E" modified="2019-07-31" version="1">MAQSHPTILELVESLANKTLQNGSDEEFLRLSARDIESSCRLLPRILASVRRASNSRRPVNTLPPEILLRIFAFIPPPPELTVFDTIEGVCGPFGIRKVWELRAITQVCYKWRSLALNVSDLWSSAFRVPHWGSRCGDIPNNACHHLYRCVAGPIHLYAEEDGLTGVNWQKLRDVDAPLDFEDRVEELHVLTLDGWRKHGSLPTSLSSPRMRALRKLVVRSLHSGNAGATSWEWQGLQSLFAEQTPPLRSLAIIDSPFLPLNPLPTLTRLVLFYQMKREMRDTWSLHDLMHFLSDSPTLEELIICGIPYDSVSGGRLSTARLGNLRKLSIRAWDYRTPGRPGLPLLLFSHLIIPQTCYLRLDVGSVEQLAELTSHLRTRLWDVPVSNVHFLLGASPYTLSSLQATFPSSGGGIRVDIPTVQGVDPSDELADAIYAFLTTPPFAAAGALWLSGLGIDSACQTRTTSSLRAFSGVKKLYVAAGLMGDQEEFVKSLGDPMSLPDSAQLPFPNLDTLYVFVDDDYGLAVGELADMLRRRVETGCKVKHLLVGCVGPEDGGPASALRKEIESLIGTVVEDVTVLGEDGYGRMCGLRTVLPLICTAAGGGLVWVPWTENETTFSLIHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHT8</accession>
    <name>A0A4Q9NHT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_974184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHT8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHT8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28012" checksum="159ECAB87B71F53B" modified="2019-07-31" version="1">MSAIPVLVVAGVGNGTGTGAAVARLFAKKGYRVALISRNPDHPNRLASEINNEGREAAAFIIPDYSYSATLSVFDTISAHKWNSEGPSELRVGVWNAGADAWKGFLDVTEQDIAKSVQVQVIAAFAFSRGAILKFKENPLDERGRRGTLIFTGATASLRGNVRTSTFATGKFGTRALSQSLAKEFGKQNIHVAHVIIDGVIDTTKGPAYQSGEEVDRDNNPDIRLDANSIAANYLNLVEQDRSAWTWELDLRPAHEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIJ6</accession>
    <name>A0A4Q9NIJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_934259</name>
        <name evidence="11" type="ORF">BD311DRAFT_763366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143451">
        <property type="protein sequence ID" value="TBU26101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIJ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIJ6"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041009083" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="26"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="28"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="289"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU26101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU55225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="445" mass="48950" checksum="AD6A35EB14B9FAEE" modified="2019-07-31" version="1">MRFLRTLLFPLVALTSLALARSSTGDTVLVLLEPSLKKENFSIFFGDLEKKGYKLTFRSPKDTTPEIIKDDVAQFAHVVVFAPETKTFAGDITPQTLVSLLSKKTNLLLALSPKQTPLSSLAAEFTLILPPPGTPLISHFPKRDTPATVVPVEPPRAHHIISDGLAPVWFSGVPQALGNSPMLVPLLQAPPQAFASDADSDSGADALVEAAEKSGEGLWAGSSLSLVTGFQALSNARATWVGGIEIFSDEYINKEISKGVKSGNRQFVKDVAAWTFQEANVLRIDTVEHHRVNETLPRETYTINNQVTYTAYISQYDPELDLWEPYSGINDLQLEFTMLDPHIRTSLPPVAGEPGKYSVSFRVPDRHGVFKFNVDYKRKGWSYLSSTTVVPIVPPRHDEYPRFLSAAWPYYAGAFSTSAAFLLFVALWLAGDEREPKKGKGSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJ97</accession>
    <name>A0A4Q9NJ97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_920905</name>
        <name evidence="12" type="ORF">BD311DRAFT_796204</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143408">
        <property type="protein sequence ID" value="TBU30059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJ97"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJ97"/>
    <dbReference type="OMA" id="YKGAIWL"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000138">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="224"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU30059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU61522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="314" mass="33830" checksum="28A043F7991D6598" modified="2019-07-31" version="1">MAHLAPSGKWDARYLGPVPHDASYYAKCMLGGALACGFTHAGITPLDVTKCNMQVFPGKYKGLISGLRTIVAEEGSHALWKGVGPTFVGYSLQGLFKYGLYEVFKDAYSNLAGEEASAKYKPAIWLAGSASAEVFADIALCPLEMTKVKIQTSTPGTFPVPFLAALREMSRLKAETRYPFGSLVPLWSRQIPYTMAKFFFFEYIVGLFYTHVFTAPKETYGKVTQLGVTFASGYIAGVVCAVVSHPADSVVSLMGKPENRGKALGQIASETGIVSLATKGLGTRVLMIGTLTGFQWWIYDSFKTAMGLGTTGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMC3</accession>
    <name>A0A4Q9NMC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_921304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMC3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NMC3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="369" mass="42856" checksum="425E2A32375686F5" modified="2019-07-31" version="1">MSITYRELASAASTAGFTRNFRHLLPVPRFLVRGPFMPGQPVPKDTKLKDRIKYWNIVPGDFVKLRGDTNGTLHEVHKVNKLSNRVILKREINKAGYVPDARSQTGLSVPYAQCQLLVGKYEYPPEDDSTEPTLKNVFASRLTMSKPYYYRKGGFWIWRRYAVNTIPRLPNYTDWTHVSIRIPWPKRNAITRPDPTPYDTTEDDALAVTYTPPSLPATFLSPAPRIPTEQEYINFLYKAGKPRIRPSDPIEVHVHKELSNPHGRAKKQARWQAFQARQKALLQEYIDAEYANLAGRTKKEARAEATWKWQQRLADDRKAELTRRWRNRGEEASLKRKMQRKQRKAIRRSQKLRNLVLEEAKNQIVPQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NP65</accession>
    <name>A0A4Q9NP65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose mutarotase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_938646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145222">
        <property type="protein sequence ID" value="TBU53186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NP65"/>
    <dbReference type="STRING" id="114155.A0A4Q9NP65"/>
    <dbReference type="OMA" id="CVAIEAQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="381" mass="42550" checksum="99298E5AAD450377" modified="2019-07-31" version="1">MVRLTGLFSIYLFTQVGLATNLVLAPDWPFDITTLSAPDESITAKFVSFGATLTELWVKARDGKARDIVLGYDNNTELLTDPAHPVFNPIVGRYANRIKNGTFSIPITKYPQPDGPNVYHIPTNDHDGQDTLHGGIYGWDRRNWTIVERNSTSVTYYHLDRADEGFPGYVEAHVTHTVENGGTLKTSIHASATEKTPIMLTQHIYWNLDAFQGSDNILNHKLHVDASKVVAVDGDAIPTGEFINVDGTPYDFRETQAIGARWNDTVGLCGGGCQGYDNCWIYDNDEEQNAGVSLWSDLSGIRLDVTTSNPAVQVYTGYWLDTPRKLVHGGPDLNYTKWSAVAIEQEGYIDAINTPEWGVDQIYYPGKDYTWESVYRFSRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSX1</accession>
    <name>A0A4Q9NSX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_883301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSX1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="452" mass="50780" checksum="ADFA1CCC37989759" modified="2019-07-31" version="1" fragment="single">MSPSNHHNRRNHRQPPPVLARSSKYRTICDLPVELLCMIISHVKSDTWTIRTCTLVCHCLRAVSLEHHFRNALSVRDIDAFDHLFSFLRANPKICEKTGSIRLSGATRKVGKHGYAPLTSIDDNTVLELTQLLPNLTALRLGYFVYIPPQLSAPRRNPDAEQDPPAPFRLEQLSFGSTTTSSSKGSSISGLFRILSMFDVDSLYGEPTGWDINAPIPFDISSLHRPLRTKKLRLWNRGSVGDRRFTMMLLEAFTKSLEPGCLRDLNLECSTVSEVSAIGELLARAGQGLTSLQVAGECPPPVASMRDGWKDPLDSHWESLNLASCPRLESININIYFRASGDEKQPTDHPALSLAGAGMLSQASGTLRKIAIWLHDLPRITTLNNRRLLRLQAFDRIITQDRFPLLEEVKLRISVHYDLRRKPSYDWQKVVLGTQKALRGLHSRGLLEVTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWN8</accession>
    <name>A0A4Q9NWN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome-450 hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_858499</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWN8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NWN8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU54457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="565" mass="63207" checksum="D2020B270B7E3335" modified="2019-07-31" version="1">MESLPSPFYPVLAAGVAACVAYLFYLAVLEPQWNPLRRLPGPPVRSFFGNHMGFVLDPSRSPRVHEAFVKHYGRNLRIRGFLPWDQRLFTLDPVSLAHILKHSTTYEKPWQSRALISSLIGVGMLAAEGHMHKRQRRVSTPAFSVQNMRALVPVTFQKGVELRDRWLALIAEVRSGAEAGTQGARLDVCHWVSRATFDVIGLAGFDYEFNAIHDESNELFAAYKEMFEIAVSQQGGGLWELAIVYAPILDRFAPGPRYGVVKKSQEVIKRVAGRLIQEKKRKIEEAEKAGSIYGGKDLLSALLRSNAAADLPPDQRISDEDILHNINTFMFAGSDTSSLSVTWILYLLSVYPDVQTRLRAELLSIAPTVPLESLTQDEIASLYTKIAELPYLENVIRETLRLIPPVHSSIRVATQDDVVPTSTPVKLSTPDGEYEEADSFLMPKGSCVHVPIEAFNLDREVWGPDGWQFKPDRWDNLPEAVKAQPGLYNNILTFSAGPRSCIGVKFSIIEIKMFMFILVTNFKFAECDKVGKANVVLTRPYIMGKHREGSQCPLLVIPYTPETPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYT9</accession>
    <name>A0A4Q9NYT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphopantothenate-cysteine ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_929136</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPC synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYT9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NYT9"/>
    <dbReference type="OMA" id="LERYQHH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="3">
        <location>
            <begin position="56"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/pantothenate metabolism flavoprotein C-terminal" evidence="3">
        <location>
            <begin position="199"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="361" mass="40522" checksum="F46D92DE197442A6" modified="2019-07-31" version="1">MTTSAQSDGANTFNNTSGESFSAEKYFATQPPPPSLEQDVARVKDFLQKQLQERRKVVLVTSGGTTVPLELNVVRFLDNFSAGTRGATSAEYFLKAGYAVIFMHRQFSLQPFSRHYSHSTHPFLDFLDINEPSGSSAPSFGDIAVRPEERAQLLEVLSTYKAVQRAGTLLTLTFVTVNDYLWLLRAVSQEMSLLGRNCLYYLAAAVSDFFLPRQKMSVHKIQSGKGSLHIEMDQVPKILKPLVAEWTREGFIVSFKLETDEDLLVPKARQALARYGHQVVIGNELHRRKFEVVFVSPKSASPPSASPALSTEIAEPPSADYEETWLTIDLEQNPEKEIEEDIVAELVRRHARWIDNATRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZJ2</accession>
    <name>A0A4Q9NZJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_807767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZJ2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZJ2"/>
    <dbReference type="OMA" id="TTPDRSW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="359" mass="39924" checksum="09227F8463F2BCCB" modified="2019-07-31" version="1">MSPWFLWHALSSTARLSTVLQILIFLPLTLSTLSKSAFLLLSLLLFLHSLIHGTLVLFWGSPALSIMQVPMHPFLLLVCFNAFSEGVHPWLTMAASWWGQILQWSGPGFIVLEGMSSLLVAQRLGQVGKELVGEGEAYQFGLLVAAAAAYVASAFWVVVSYPATADSPLSSTLLGVALTTLIFLTFIGFALRRTNVIETSCLALIVAYNVWLCGVDDALVLDTGLQYTPLVSNILPHLQTLANFVSNTVPKPVLFALVYRLCVLHFASHILPTIGADSWEDETGVDDGWEGRPTSKLTYLLLTYRQSIFVTVYSHLLMLDHSSQVWWRWMNIFFTLAIWSIELLVSNEDDDVTKKWKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3C7</accession>
    <name>A0A4Q9P3C7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_905088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3C7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19270" checksum="0A74891778AF6A10" modified="2019-07-31" version="1">MTPFPGAYAPYAMPYQAGGHTVAYGLMTPPESPEKPSGRGLDFHHALDARSSHLMAFDLRQGMFFGSEQLGTQAVNHPVRILRVSIGPLCVDITNERGMVPTVQDVAYGLARALRMSEATPQEVAVAVSMGFVHPSTPVRGTERARLLDARPFFGGFTLRTVQHDVAIVDCHLRARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6F8</accession>
    <name>A0A4Q9P6F8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_820080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6F8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="305" mass="34869" checksum="B9442FACC0AE70C6" modified="2019-07-31" version="1">MSKPYYGPHESEDDINLERFFLAGDFVSGVGYGMQLVLWSSCALYLFQQRRKGRHTTFLLCYISALLIVQTIYSIAQARTVQLLYVENRNYPGGPWQYFLATQSQSINIVYFVTLYLAIFMCDLLVLWRCWVIWKALDQHIAYIVTFVPFLMLTASFVLGTLWTVYSTQPDFSLYNTLPRSYGIAYFSLSLGVNIILTTLIVGRLLMFRRMHMEFLPPEHVKRYLSVATLVIESAALYSLFAIAFLISYALEKPVNQVLLGFTQASQQVATYLIIYRVADGKAWSSKETAPSVNFINELPTSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6W5</accession>
    <name>A0A4Q9P6W5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rhomboid-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_926515</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S54 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6W5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6W5"/>
    <dbReference type="OMA" id="VFLAWQY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050925">
        <property type="entry name" value="Rhomboid_protease_S54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731:SF14">
        <property type="entry name" value="PRESENILIN-ASSOCIATED RHOMBOID-LIKE PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43731">
        <property type="entry name" value="RHOMBOID PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="164"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="315" mass="34060" checksum="A611AA411CE35675" modified="2019-07-31" version="1">MKRSLLSISPLLSSARLCSGPLQHGTWLGPRICTSVRHSTLSTGALRQPLTLLRTPPSVSQGYSVLRFVAGTLLRATHRSGLNRSSRGGSGGYGGGPNGPWQRFRDRLNAIPGNVLFWGIIGLNGVVFVSWQWAWAKYKSMGDASSYIWMRNHFIASADNIKAGRWYTLLTACFSHADTSHILFNGFTFYFVAPLVISILGNAGFLSLYLGGGIVSSLAGIAWRNYKQGNQPSGSYGASGAIYSVISFFACVAPTATFYLFGVLPLPAWGVVTGIFLWDGYSAMNEHRLGTDTAGHIGGLLAGIGYFIAKRFRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8X1</accession>
    <name>A0A4Q9P8X1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_910930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145455">
        <property type="protein sequence ID" value="TBU51004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8X1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15037" checksum="E3282F5B22CF4015" modified="2019-07-31" version="1" fragment="single">SSDLWVPSTSCDSCGSHNKYDLSTSGKESSSFSISYGDGSTASGNPYTDTVLILTPQPAVGGDKVIGQDLAAGTQESPSRTTRTVSLASHRRVAKDGKGGPLWLQAHLLRLRTLHRWHELGPLQGRRCRKKGVAFGRSANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9T7</accession>
    <name>A0A4Q9P9T7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AhpD-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1008598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145367">
        <property type="protein sequence ID" value="TBU51188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9T7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23182" checksum="450F903465428FE2" modified="2019-07-31" version="1">MSRVPPVPLETPGLIAEDIRALLWGSHKGLEPLITTLLHAPPVAEGWSKLMGAIRMGSTLDDDLREIMARRSAILPIAALNKASFEWVQHETLARAAGLSTERLARIGDVKVSQSASSSPAGPCQPSAIQAMTLLLVDSMTVNVQVEDATIDGLRLAFLNQGDDKAAANRKVVEAVAMCAVRFLVALDIDSRAKVLCPVPAGERPGGSTRIEILYDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAB6</accession>
    <name>A0A4Q9PAB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145298">
        <property type="protein sequence ID" value="TBU51630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAB6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8784" checksum="1B5A65FF3DC7C3B4" modified="2019-07-31" version="1">MHWGLPHRLAMSRHRRPPPLYGSAYSPPRPYPSPDPVWMWALSVCSLVWVGAYAQCLGKLSCGQYLSCGPYAARRPGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAD3</accession>
    <name>A0A4Q9PAD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_982412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145296">
        <property type="protein sequence ID" value="TBU51650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAD3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAD3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="549"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="658" mass="73690" checksum="0EEBB29694EA0F4C" modified="2019-07-31" version="1">MEAEHFPAIQVIAFEEHGSTSSPPACATGFKERPGLSHSMRQRPPSPSPQASSMLLNDTLAPEYPGAPERPLSAVSCASSITLSGVQANALPSTPENPTYFSGPLTAEPESIIAGISEGDPEESKKPVFLAPTPATFCHDLRYERRERLDLNKLKTFFENIPAKNAIPARPESLGEMGWKQYTHPEGNSYFRHKNFYTNTWLHDELMLKRIEIAVELILTELRNHSDISQEGIEVGLELSQDEVGDILGCYYLVDIKTESTFWLHEIPACLLSGTDSVKILGREHLNRVEDLKSDLNYFLLDKQTSKSSTAPYNVKDARSLVQIIKEIRTEPNGPTRPQQVVIVCRLMATIFRERFIRYHGEPYAQLDSDRSVYQETHQGRHLWFRMFSWISFWTPQIYHDRLSKTWVDSKVNYDQWGTFIGELQKDWEASITPSTVILTANVSFLAIQSVDDNGVVIANRSMGQIVSYISTMLTIGNIVACTILTRQHRQATHQYAEAAAGYLSSRAESKVGLEVLAILFSIPTVFFAWGLLTFLIAIIWVCLWGTSVATRISVCVVIGIGAFLIAWIVRNGDWQAQQSVSTLSAKMKRMHKLVKKVPRRMATGLRTLSSRAMIMTRWSLAKPLSARRSRWSGPVSDPSNTPGDVGIYAIPLGDEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCV9</accession>
    <name>A0A4Q9PCV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1043694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145414">
        <property type="protein sequence ID" value="TBU51067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCV9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="174" mass="18263" checksum="BC89F16613E0EE26" modified="2019-07-31" version="1">MSATACRNRTCAGVGGRDVAGCAGRAEEIRWGIIQASSRMVYLGTRRRGGGTCVIRCLRRGPCAVICGLLSESNAQEMPGRETRTLGVGWKMGVGWKGSWVEGQLGGRAVGWKGSWVKGQLGERRALGGKAVSWKGSVRWWKVGVGWKVCVGGRAVCVAGKSALGGPGWKTGVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD18</accession>
    <name>A0A4Q9PD18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_888997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145240">
        <property type="protein sequence ID" value="TBU52689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD18"/>
    <dbReference type="OMA" id="KWWNDTT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="516" mass="54690" checksum="4F1C34BDA43CBD2D" modified="2019-07-31" version="1">MKSGFKTVRLGHAVGLHQHTNQLNKRDDCLTGGLYKTPTKGQTVDASQPVTISWDTSCLNTTAVDIYLYAPSGNPPLIHEWENVNYKTGSYNATLKPGWWNSTSSVSLEFTIIPAGQPIFAVGGAAGPLFTATYSGNSTGDSAVAGAVEQVNNLPTEKHGPSKGAIAAAVIIPLLFIIGLIVVAYIRMNRQKGKEKRKRFSEMVDKRMSTISTDWKSLSGAGANAAIRNSMAVPGNRTSSFSFGGIRPASTVAVEGGQAGIGARGILAQDGLPPDAPYMSQLRPGLRTSAFENRVSRVSFAADPRPSSESRRARQSRAFHTSSVVVPPLPDRQHSSESSSNSSPILSPIQTAGPLSLTHEDIQARMAGGDAEHQSNYDEFMPALTMMRLGEQGGAQVEMPSAVQMPTPPSPTHQAPKSPILGAMPMQPMHANVMSPDAMLRAYAERRAMGATVPGSPAPPTPAANYNSMGMRVLYSPDTTASASSSTVYPVAASNSRKNLANTVYDDEDAYVGTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEJ1</accession>
    <name>A0A4Q9PEJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1043002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145247">
        <property type="protein sequence ID" value="TBU52535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEJ1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEJ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="179"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="323" mass="35701" checksum="6CCA82247C4B49C7" modified="2019-07-31" version="1">MPAILVEEQVSDLSALLNLVTASFAAFLIGTYLSIFLYGLNVHQTYRYFRSFSTDALYIRWLVICVMVLETIHFIGTIDVCYYYLVVNYAKPEALLKQRWSLTSLPVWTALIAFVSQLFFIRRVSLITPRFHIVIAVVALGLLSELGLTFFSLAAIIIPSFTAKDAAVLGAAAFGMAGLADVALTTALVVSIWKSRRGRARPQSESWIDVVQLYAVNTGAATCFFDLLTFVVGLALPPAQTLVLASLGCIVARLYCNTFLAVLNSRQQRGMEFVVDGERKMSIVEAHIAAKLDLWNAPQLPQATAPRKISIQVMQESEGSRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEQ1</accession>
    <name>A0A4Q9PEQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ras-induced vulval development antagonist-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_890639</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145308">
        <property type="protein sequence ID" value="TBU51552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEQ1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEQ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="165"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="62965" checksum="4001CE68478BF61E" modified="2019-07-31" version="1">MAMVHPSRLGLVPQDPPDLGKRGRSPSPPPRSSRRRSRSVDSRRDRDKSGKEMADKKREEDRDRADKKRDEDRDRDRDERRIAYGDRDRDRGRRHDRDRARADDYFNDGDRDRAGGGRRDDRDDNRGPRRSKERSVDRERDKEREERRERERDSGRTRRASPEYGDYRRSSPGRAREDGRDAAKEGENGAERAPWRQQENMYPNRGGRQPQHGGFGGGADFLESRRQQREASTVTVWPPSPKAPTRVESPTRDSKHHKKSHKRRRDYSDSDTDSNSSEEECRRRERKERKKARKEKRDRERDRDREHHRHRSWSHRHSDDEDSDREHRRHRGKTRSRSARRSVSHRSATRTKSPEQRPPSTPDEDEWVEKPVTGVVSSLSQPALSGSMPLPAVPASASAKGKQPAQGGEDSDEEVGPQPLNAAKTSSRNKVDERQYGGALLRGEGSAMAAFLKDGTDVRIPRRGEIGLSSDEIAMFESVGYVMSGSRHRRMNAVRMRKENQVISAEEKRGILKLQQEERERREAILREEFQQLVQEKLKSGAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEU0</accession>
    <name>A0A4Q9PEU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_981071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEU0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEU0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF2">
        <property type="entry name" value="ACYLTRANSFERASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="272" mass="29396" checksum="D44F537A3EB76F44" modified="2019-07-31" version="1">MRSILLVAVLPAFVGAKTLSVDFSTFASSGLTVAQFLDQSSLYVSAYEVQTSYPSDPTADPFPHTFVTDNVDIQDGYLTLKVSGPTAQGASVLSAEVGTYDSNILYGTFKTVAIASPVPGVVHGFFTYKNDCQESDIELLTSFYTTGNTFVQPGLQLTNQNLQCDHTQNTHTQVAYPADPTAAEHEARVIHPSIPFSSHLRSAPYTLIWNSSATTYLFDGTVVATLNSNVPTEPSSFLWNSWSGGNERWSAGPPTQDAILKIKSISLDYETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF08</accession>
    <name>A0A4Q9PF08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_910445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145284">
        <property type="protein sequence ID" value="TBU51807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF08"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="38"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="35286" checksum="C4063E02CF646F1B" modified="2019-07-31" version="1">MSSDSSPATAQKPTVTVDSDTISNPASGFRKGSAFWLTFIAILVCSFVSALDLTAISIALRTITDSLNGGDKFVWVGSAYGLASAASLPLSGRLADTFGRRPVMLASVGLFFLGSALSGASQSMDMLIGARTVQGIGSGGILNLSEIIVSDLVPLLERGMFMGIISGVWDWPPDYLNLPLTGIAFVLVLLFLRVRMPPGTIGDKLAHLDTIGNLIIIAGTTVALIGLTWGGVAYKWTSPHTLATLVIGFVFIGMFFVYERLVPNEPSIPWEVVSDRTTLAAYAQYPIYQNRELNILQVHRNILPRPNEYRRVLLVGALPHSGPALSFCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF18</accession>
    <name>A0A4Q9PF18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_991591</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="ML145211">
        <property type="protein sequence ID" value="TBU53544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF18"/>
    <dbReference type="SMR" id="A0A4Q9PF18"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF18"/>
    <dbReference type="OMA" id="QRYWIRD"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU53544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="694" mass="77366" checksum="E53975C50E7FFF74" modified="2019-07-31" version="1">MTKLAAAERFLADKAAPYCSLNVAKSFELLSPKEKKYAHYIGQASWAGARIIQGQWTPQAEKLYDLLILTFSENGKLVDLEALQQKSGVSADEFDDLLQYTGQVLSNLVNYKSFGFTKIVPRIPEDKFAAVVEKSANAANAVPLWNELKGPIYQLDPEPSNSIGKRSLGHISNYYLGEPPTDEEVAAIQAAAEKLSLSVLNTRVRKDSPDTFALLIASAETKPKEVHEFKIGERHAKLSIEYGDFSDALKKAADALEEAKKYAANDHQVGFLEKYIESFRTGSIEAHIKGSEHWVRDVGPVVESYIGFIETYVDPYGGRAEWEGFTAIVDKTLSAKYEKLVNDAPELIKVLPWGKDFEVDVFRKPDFTALEVLTFATGGIPAGINIPNYYEIREAHGFKNVSLANILAAKAPNEELTFIHPDDVELFNKWDSRAFELLVANHELLGHGTGKLFNETADGTKNFDPEKVINPLTGKPITSWYKPGQSWGTVLGEVASSMEECRADTVGLYLSSNRDILNIFKYTDQQDIDDIQYITFLLTARAGVRALEFYDPVNKKHGQAHMQARLGITQHLIKSGIARLEEVRAADGTLENAYVRVDREMVLKEGRDAVGRLLVNIQVRKSTADGPGAREYYTELTTPLPGWEGELRDLVLKKKLPRKIFVQPNTFVQGDEVVLKEYPLNPAGAIESFIERKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF62</accession>
    <name>A0A4Q9PF62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_156471</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145214">
        <property type="protein sequence ID" value="TBU53428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF62"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF62"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="520" mass="57016" checksum="D030F71A001B21B6" modified="2019-07-31" version="1">MKVSAFSVLGCAPALILLKLGCLARGAYVLDGRTLPDDFIFSCGTSAYQIEGATGSQAEGGKGTSIWDTFAHEKGLGHIANDETGDIAVDFYHTYPRDLPLFRQALGVNQFDFTVAWTRILPNGTGTTANPAGLNFYRDVIMTAHRNGMTAACTIYHWDLPQALQDKYGGWLNKQVVSDFRNYAEIIMDGLGDLCDDWLSMNEPRTFCQEGYGADPVSAPAIPNGTFKTEITCRHNAMLAHAEAHEVFVEKKKQGKVKGKFGIKIDGGPGVPMDPTSAADVAAVDRHHAFEFWEVSPLVNGTYNPTMRTALGSLLPSFTAEETKKVAGSYDFVAFDAYTSTWIAALNASDAAACTGEQSDFWPECVEDSETDHAGYLIGKPTESDWNFRANDTIYVGLRYMHENGIKAFTVGENGMAVIKEASLHLGERVVDADRVDWYRSTFKNINWVLDAGLPLIGASFWSCIDNLEWSSGFTIKFGLVDTKPGYNQTRTSKMSANYVKAVMTGELDSRYSYFPSEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGL7</accession>
    <name>A0A4Q9PGL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_981846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145249">
        <property type="protein sequence ID" value="TBU52487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGL7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGL7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579:SF2">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46579">
        <property type="entry name" value="F5/8 TYPE C DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="2">
        <location>
            <begin position="959"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1184" mass="131386" checksum="85DB4A3490E5F269" modified="2019-07-31" version="1">MPGPKEADPDQVQRYMRVLVNELIRLWKYGAMVPTPKYPKGRRIRVILVGVVCDKPAAHKLGGFGSHAHTYFCIQDWISQTFKATVEAFKANAFRTRTDAEHRSFMAQYQQCSSKGEREDFARKYATRWSELARLPYFDMCRMIVVDPMHNLFLGLVKTHFYHIWVQLKILRKTKELRQLHSVLEKLELPATLGRLPRLIGEPAGGSLTADQWLILATVIGPLVIPDIWRDCAPDPDGSRLQQRLSALTGVAAKRRAQRTTRYAAPGGKAGSKRKRTSGRVKKRAPKVSSASRTDISGQDPLMAPRRTQRVSKPTEKRRDMVLESDDDGGIEIDAEENWSDDSSDGDDAWSAQASIHERDVPNFLKLAEALTTFLADELSEDDVMIADQRLREYCTELLELYGPAIIRPNHHYATHTGDFVLDYGPLREFWTFVFERLNKVLKSFKTTGRAGGELECSFFREFHRSVRLHRLLVSGLDEAADPGLQASCDAMLAAAADDRGTLQNLVQDLDNTFADKGKICELSRRASREMFPEDLYYTLLKHVQSRHPLQQFHSFISLAPSPTSTLVPNIATFFDYAIIHGHRYYASRRTISPRNSLALVQWNTSGSPSQRRHAGEITDIFMFEHPSVGAVYLAAVRWFRTSSTSIADTPWASQGPVSRRSCSDMNSSSFDCAAPSIHFRSHYSVSQYSMTAGDEYEGAVDAFGEPGAVGDYYDQASTPTAVKDNIHPSQTKLKLLLLVPRCPPLNEVDSPTLSLMVPLLSRGLNEKLTATKRKVAVIIDKTAKVVDSPVTVRPFIPKLLPGLIKIESVIGDPVARSVVARAIATLRQVGEVPTGDGSDLPPLKKAEEKTLAHSLIDLYKKAGANPVPSVADVATIYASQLATNMVNVKKFEVSEWQTLIPYLVFLITSPDPNTIVNKWAVKSASAEVEDETQAEDEDEGEDLCNCQFSLAYGAKILLNTATVRVKRGHRYGLCGRNGTGKSTLMRVITDGQVEGFPSPDEVRTFYVEHGIDGSEANASVLVFIISDKCIQATHEEIIGTFASLGFSDEHQNLTTCTSIIVSHDSGLLINVITDVLHLIRFKLKRYRGILDAYMKAFKLPDPPLLEGVKTEKSLLKMRKVGFQYSTQANQQLYDITLQVSLSSHVAVLGPNGSGKSCLSTFSLATHAPLLTGSVANGHICMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGN7</accession>
    <name>A0A4Q9PGN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_1043046</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGN7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="310"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="176"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="386"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="525"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU52452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="642" mass="69698" checksum="703C1A0DCC9EB61A" modified="2019-07-31" version="1">MTSPYPAYSPRMPSSNVHYSNINTNASYPYPPHSRYDASAASLDSDSSTEHEGDPVKPAQKEYGYGDRQARPGVAVDVRAINRTPSPTPSEAEELSKGILDWDRLLKWRYWVRREWLWYYVIFVVALTGGILFTVYHKKIVNWLKPAADWMHDLPYGWLIPIGVFFVISFPPLFGHEIVAILCGLVWDLGPGFAIVAAGTFIGELGNFYAFKYCCAARGEKLEKTKLQYACLARVVRDGGFKIALIARLSAIPGHFTTAVFSTCGMGVITFSIAAILSLPKQFITVYLGVALEQSEDGTSSTKDTIIRDAVLGLTTLMTFGAMWYIYHKMNQAKPLVIYDRRKARQAKLMEMSGAAPSLPYGSGNSVMLESTTSVSFNPAASSADIPLTKYGQPQSQYQTQPGVYAPRPQRPGEQYPMSQYSNDSHALPPGAGYPYPTPASQLPSRPVASPPRDPFSDAARVPNYSSPRPQPPSQPQPQGISYQRQAPPRGYGSPPPDMLDKRGGGSRPPHTYTQSTPAAQRLSSPPPPAARPPSPSAPQSPTPRNYPAPTGPPPLPSMSGQPPRTSGDGTNPFADPSPMPNPYEQGRQGGGHVEEPSDATFYTAAGGHSRGGTEFDAAYEATSMASTEGSAPPAYDEHRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGU3</accession>
    <name>A0A4Q9PGU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_831934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145246">
        <property type="protein sequence ID" value="TBU52562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="61394" checksum="C019E3F8D276370F" modified="2019-07-31" version="1">MIAGTNAEEVIPCADSTGPDPPHPALYNQDVLALLFDVFNPFNRTDRATCARSARVCRAWAEPASSVVWSKGVDLTILFRILHRPSSLDTMARKISSSDPGMTQEKLQVIRHEAWQSFLRCGARIRELSEGTFGLIPAYVELTHFLIRKNGTQTFLPHLKTLHWRQRADSSGILVRLVPPSLESLVLHVDELTAGCPLGTLGLQLSSAAPFLRRLEITCQTGLPISFLIPLKSIRELTLHNVLTAFKPEDVRRLLKAPNLEALHLSIKNFAKCQRVMDSGPNLRSIYCIGMCEDLASFISLLDAPNLYDLGMYLLRPGDVDALRSLIGELKSAPCTRSVRSLKLIYGNSALRCDPTPLRYAVVAPQLAVGKIILQPLFGHFNQLDTLIVGSCHCPSVLTDDDVLMLAKAWPGLKKLSLPSHATSPYCSRVASFPSVASLYHLSYHCPELIHLEIELGDITLPPKFLQYPIPRIAHRLRTLKLSSLRWIEPDALALVLAEVVDGLFPTLDVDVCIRDKRPHLQWHGWPLMWAKVRELQAGRERRSIKNWQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJU8</accession>
    <name>A0A4Q9PJU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_936069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJU8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14456" checksum="D19D7A087C8F66AD" modified="2019-07-31" version="1">MSSTFPSFLGLPFANSRSWRPSGSVGAQAMLCSRRRGFTAYASHRPLLFSRSPCPTRRCDQTPCPARELCVSAPMRDTSVTVKGAAANIDLVGLRGTPSPFRSSGWWSVKSLTSEGRRVVADLSYRDGLPESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK35</accession>
    <name>A0A4Q9PK35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_827875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK35"/>
    <dbReference type="STRING" id="114155.A0A4Q9PK35"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47381:SF3">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="33831" checksum="E0C6403DF9701A9F" modified="2019-07-31" version="1">MFKLGHSKHAAPESHGKNLKPHKETVVVAGLPVNVFSDRGATKPETPVAVMFLLHGRTGSAKRMETYVNDVFEEIRARRSAHKGAQDLIIVTIDQRNHGARMVDERANMGWFPEPEKNNERHAIDMYAIQTGTAQDVSFLIDFLPSYLFPNGERTISQWLCAGKSLGGHSTWIVLKNDPRVKIGIPIIGCPDYLTLISKRAKAHKLPVGPPYLPDSLIELIRRADPAAAPYTATDESNPFLGKKILVLSGQDDKIAPFSSSKEVVEKLNVGKHGLKEVIVEPGVGHDLSPAMLKEAARFIWEQALVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKL3</accession>
    <name>A0A4Q9PKL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_908750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKL3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="222" mass="24110" checksum="5DC29B2EB1945942" modified="2019-07-31" version="1">MKWGIQDYDTIVDRDVGRRVTRKVAKAIREGASIPNESLSYRGHQEMRGSTTVASNPSMTPDSMVSSTGSEITAKADIQPEKDSEEEETTEVGTLLNSEDDQLAVQSNGIGGHDAVEGDLGADESALVPSNQWKVVQARCGPEPQTTGILPVVTRYFPSWFDLCDLDDQLGPILTEWSMSMAESPLLPEVPSGGTSLLDEFWQEVDSSDEDSELQCAIAESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKR1</accession>
    <name>A0A4Q9PKR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_728839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKR1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="333" mass="37386" checksum="939F4A689E71A0F2" modified="2019-07-31" version="1">MSPTDCHLAPEAKRDEEIWFEDGNIIIVAGDTAFRLYKGILSAASLVFKDLFSVPQPEDGETMDNCPVIRLPDPATDLRHFFRAVTKPDFSHLRHDYKPAFGMLAAVCRIGHKYQADEVVDAAAARIENFFARWPSTAATIISKNRGRMPLTWELFWWAHNRLCLTAVEIQDAFEAVGLARLLGRPSILPFALYLCCAGDPLHMRDGVPRPDGAVSRLSSEDYLRCIQAIPKLRAACSDKIRSVLARSMTASVLSDCTNGGQCAEVFEMMHRDFIEEKYVPVVTDLFASIRFLRTKPVAYTTYYLCLCSKCVLRLDVIEYGGEAAFLTKVFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKV8</accession>
    <name>A0A4Q9PKV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_729812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKV8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16913" checksum="66181D7932E5E060" modified="2019-07-31" version="1">MLYTLQKDTAPRITALRYENPRLSPIFPRLRVSPSRQRDSGLMQRTVGTQIAQFKSVPHLNRLYSFSIKRKYQRICSAWYTSYGTLLGRATNSHSLNYAGFQSQQAKNTTDLWLLGSKAFAKQPITTFAGVSQHVTTGVTHVLRARAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKZ2</accession>
    <name>A0A4Q9PKZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_934991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKZ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13611" checksum="DDBEFCF58E11C1B1" modified="2019-07-31" version="1">MSTVTEDERGNRCIGSHDELQRCHIQAYLESCPRTYCCSSSPLSHTCPSSLYRRLTVRRSSSSIPPFLSISCVKAAFHRLDDLMRVLDTHSGQFVQADLQSITSAILSHTWDREKAGCQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL42</accession>
    <name>A0A4Q9PL42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1041471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL42"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL42"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="6">
        <location>
            <begin position="100"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="319"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="417"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="515" mass="56585" checksum="9186ABF86C1A987E" modified="2019-07-31" version="1">MSKRSATEVNSSSGSHLEPRKTPRSESKRKEDAADDEMGEFEDGWEDEYESDEDVVDGEQGKGDDSMDVDDEVMPPIEESEEPPQAPEAFIPGVHKLGKDEILEPDDSVYIMRHNMTVNWPCLSFDVLRDNLGDQRQRYPATVYIVTGTQADVAKNNEIQVYKMSSLHKTQKEHDTDDEDEEDDDALDEDPVLEHRSVPHLGGVNRIRAQPLPASSPLPPVSQPYYVASWAETGKVHIWDVRPLIEALDVPGYAVDKSRTHTPAFTISSHGRAEGFAMDWAASGGANPSALRLLTGDVHAKIFLTTTTPSGFNALAQPFASHTSSVEDLQWSPSEPTVFASCSADQSVRVWDVRAKGRQSVAGIARAHESDVNVISWNRATTYLLLSGGDEGGIKVWDLRNVKKAGTAPDPSPVAAFTWHTAPITSIEWHPTEDSIFAASGADDQVTLWDLAVEQDDEEAGPMDATEGGREVPPQLLFVHQGQKDVKEVHWHPQIPGAVISTAYDGFNIFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL72</accession>
    <name>A0A4Q9PL72_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_951125</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL72"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL72"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="289"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU54894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="767" mass="83970" checksum="E94302FE72159A69" modified="2019-07-31" version="1">MIAEVLLVLAGHSSSLFPTDHKVHPAFAPLLHPGEEQCLESLGQIALCYRKIKDACSVLARPSSRYVSALCATLNQILKDEYEVLVVETEAKVLKRDSSLVASGSFVPLSSLRAIFAEWDAPLASLETLVDDLQAHERWRPGPLIDLLLTRSQTGIHRVSSIYARLSEAVQRVWIAQLQAVLIHGTLSPNDPLADKNYVLVEGAVPSCVSVQSRDSITYVGRAIGTVKAAKWEKQFPQDLAREHTKLLNTVIPQDQYSFDRVISDIRTAVSEWLWLNVLTHKDVDEAVESLANYFLLRNGEFALSLIREIERLKLSRLTGKSVPSTMIRDQDLHLALLRASLGTTAQQDPSLAHLHFRLPTGPIRPLLPSLAGGAKDLSASLSSPTEPTSFDDLLLGTPLVLAYDVSWPLDLFLHASDLQLYAALFSYLSALRKTHTRIHTCWTALSNAQRARRRWTGLGEGGTAEDLEVRKQLLRCGWGVVREMTWFLDTLLGYVMTDVVDVEFRRLKSLLSGRPTGGVGRQMTGSGSAGAVAGSGDDRIGAGPLGASKTGSTFHPSLSTGSNLSSGAPPLDFTTLRSIHATYLERLLTGSLLANPALTNIIRMILEVCERFAAQVERWGGDVLPALLFEGSLAAGGGDKVGEMVAERYAIVGEIDVTLHTLLDAFYEQLSLSTTLQPFSATIDATKSMLYNASMTNTTGFGFHTFVRTRRGKRLEGDEEVRRHVERLLLRLDFNGQFSKPSARRHGTRSTAPAGQEDILKQGGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLQ2</accession>
    <name>A0A4Q9PLQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_1041405</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PLQ2"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14297">
        <property type="entry name" value="UBA2_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBA" evidence="13">
        <location>
            <begin position="1324"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="3403"/>
            <end position="3738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="745"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1024"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1362"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1855"/>
            <end position="1891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2113"/>
            <end position="2298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2366"/>
            <end position="2390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2547"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2602"/>
            <end position="2648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="2786"/>
            <end position="2823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="3024"/>
            <end position="3101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="237"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1024"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1054"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="1366"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1380"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1444"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1855"/>
            <end position="1888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="2113"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2130"/>
            <end position="2149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2173"/>
            <end position="2260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="2270"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="2800"/>
            <end position="2816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="3025"/>
            <end position="3035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="3036"/>
            <end position="3050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="3051"/>
            <end position="3065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="3068"/>
            <end position="3090"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="3705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU55065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="3738" mass="408798" checksum="0AC790141A2E4D82" modified="2019-07-31" version="1">MRILHKSKRVVAPLPQVAELIDRLINTTNDDLHEVLSQIDSWKWPRSDLNAWMKVLNKFDAILEEAIRDYDIDNLQVNVFTPLTKKTVCEILRFERLLLENSTNRKTFNSYDRLNSLMFSSDLDVLILALNLLLRPAQQYSSQPAVSHALSISTPRLASLAKRWPNLRDYDLNLVDLVTNKGRAQVEALPTEAREVNFVFYRQASSSSTAGKEEKKESIVEGDVSSSAAVQTPRKPTSSAAATSANASTSSGAVTIHIDSKTIESKPAMDILADAIEAYHVPDSEKFELLMRIRGAQAMTHAWAADREKLVVVRLLATAIFGHTHSDSQAQSSLFLYEPDLITHIAELLQLDRGVDIQVQTAAVAALDAMSRYRSKIQDVLTAVNAGVNHGILMALLRKTVADVAQSTSTLPQAFVEALFSFITFLATHASGGSMIVGAGLIPVLIQAIENRLPNRLYVVSKTMQLLDNVLYGYTNAFTLFCNARGVDILVDRIEYEVDLDIEECANDGAPNDAVAPYGKLSVARTAVLKHTLRSIHRMMQSSGTAEGLRGLLDSSLLKSVKKIMQHRAIFGPSALALAINIMAIFVHNEPTCLPVIQEAGLPEVFYSVIEKGLEPVIEVIQSVPNALGALCLNQAGQDQLTARPNTIPSLFSIFTSEDHQRVLQEKENAVLIGTSVEELIRHHPTLKEKVFVAIKSTMARIEELGTSYSVPDDIKHWYRLQPQNPAPAPAGAESTGENVAMEVDHSTPATEQATLPASLPPSGEQPSHRDDFWGRSHDNLIISYIDVFGKFLEGFFQHVPHCRDFVADTDGLNGLAKLTTLPCLPYDFANSVASDSFVQVVRTMAEAATNETLAFLVRLVQESLAECKDFWGSLDEQPKLLGLVEFSAGAEEEKANTQFRNLITLHTRVSLLSDIYATAGYSHGRATQTLLQSLLGKTPNPLQELGALHRACVWENIILKSILSAQGIDASPQHDLLALFGSASTPTQGVLSSTLSATTTATANTSSTSAANGASASASTAAANGATPTSATNANGATPAEPSASTSTPSANAKKEEQPRDKNAKGVKHLVGQIPSALAPFFQSIVRLFQTRRGSDMAQKQKIKEAAGIIADVLVKHLEQKSFSDKLSLFSYYTSMLNAATILLVDEKPSQKSLHTMLLVAFVRVGGLDALFGLCREFINTIEMVSKVKVDERTEVTKQELSHAFSGLKVALQLIQPTISAKPLFDATQTALALTVDKKDTDADYFEPHNFLVRMRAAALPVVRSIWEAEWLPSAPISVSKLVVHIVMELLNAENEEVKDVQTSASIIGGGPIGMPRIPPMQSPDENRIRQLTDMGFPRSAAERALTRTRNNVNAATELLLSHPYPFPPDPDPAPEPAPAAAEGEAVAVPAGDQDQIQADTPDAAPAEAGDAPAEAPASEDNVESGDAAETAQGDATEETMEETSSTASDSEAPAAPAPEEVSAPPGKTSEEWVMELTAAREPLKEGIGRRVLSLVDEHPSLVFDVQKVFIGPTSEYRTQAVKALIDDIQAFLPSAYDVQEQPLSVRCHLLALVLGEPSSPAAQMPEKEAETLLNVLLSLLLSNPGEGGQPTLPKWLSAQLLVIESLLVLGDSPRSVTLPKENEPINREPIAQGPRYAEARNTLFDFSMRLLGVPTLPKDEMISVLRLIVLLTRDHNIAEAFMERNGVAALFQYLRISSGTQSGTGIQSYIALIVRHIVENQITLQHVMRQEVKRYFSHPRSRNVDIGSFVSGCSSTALRDPEAFVKVAEEMCTLSQPFSPMKTVSLKPEVEPNATFQHAIPGGNKSNEMQIDEAPVQQASGAPVESTETLIHYLIGELMKTVKTDMAPENLSAATSVDTGKLTSTHTPASSENRTDAAQPSSTELRSPQDPVDYTYPCFIMQVLTELLFSYESCKIAFLSYTPKKRNQTPAKEGGLKHRTAAIQFLLSDLMTFGTINPQPPSEARKQITLCNWAMSVIVALCVDTVTNQDLKDVPTDLISVRKFVLEAISRALKDLPSSDSPELRYGRLLALSDLCHRLLTVRFNVNGKKAGDEVPTHIAKVMLEKNFVATLTNVLSEVDLNYPNIRNVVSSVLRPLEYLTKIAMKMSRVSDKNKEVLEEKQAMSESDISEEDEDEDDETESPETEEASQLYRNSSLGLFGGEMEDVHYGDEDDMDEEDDEDEDGDVEMDFGDETGSEDTSATDEEDVEEDLEDETGESEEGWQEEDEEDEEGLVENEGQAAEEEADEDDEDEGEEVMWQDIAVGDGGADEGADEGEEEEDVGDMPMAPMDMDDEGDVISEGEEFADELGLVDEARLGHGPNLFDLAAGFANVLGGSLAAGIHGAPDGEPVVWTGAVRSTRRRGAGDDDLDIFGRSRNPPAPSAENVTHPLLLDPATAAARASQARSSRRGHRGLLAGSGVDIDQALGEGATQFLQQMLTHGRAGGHEALHINLPAGLLANFPRNGRGGAISASIRLERAPRPTDGRTEGRSLEPLLTIQRWSEEVKMLHGKFEQARLSRLHNHVVLALLPAAAEAYKKAKEAEEREQERIREEQVRAAEEAAKKEQEAIEAAERAKAEEEARAVEAAAQAAVEAEAAAAAQESAAAADTDVEMADDSPSAETPAAENGPQTAESSNRPEEAAAPAQERVTVMIHGAPVDITDTGIDPTFLEALPDEMREEVLNQHVRDQRAAQLERPADSAISAEFLDALPPDIRAEIIQQEAAERAQRTRAEQATQQGGPLDIDPADFIASLDPQLRQVVLMDSDDVFIQSLPSHMIAEANIHREPGRPPRPRQVPPRQGGAQGAPQQASQPTKAPQSREAIQLLDKSALAALVRLLFYPHILKKNLLYKVLVNLCENAKSRTDLFNLLLSILQDGSGDLASIDKSFAQMSVRHSRPTAPQTPKAIGKQRVSTDYFGSLSLPQNDVVPELIVQRCLEALTYIVSSNELSSLFFLTEHELPIGLRRSSSKKGKGKEKQAPQTHYPIVLLLGLLDRPSILRTPSIVESVVGLLATVTRPLASLKDKDSKKSENAESSTAGASTASPGEQPSSGAQPVDNTQSVIVPDTASFDPAPAPTPASAAVPATAQGESPQKPPASVEEKVLLANPPHIPHHVLRLIVNVLTAGECSGRTFMQSLALIQHLSYIPDAREVIASELRSRAQEFGQSLFAALDELAVALRDADVQPDVLATTIAAMFSSASSDQAKLLRVLKTIDYMYSPKTSGNSTEADIEKVQSIYETFRFSPLWKRLGDCLSIIEEKPEMEHIATVLLPLIESLMVVCKYVGPKTTSGATARALRASTSPRSPTSARESMEDLFVTFTDAHRKVLNLMVRNNPSLMSGSFSLLVHNPRVLDFDNKRNYFNQQLHRRPHSREHHSTLQLNVRRQRVFEDSFQYLQRKTGEQIKYGKLSVRFYDEEGVDAGGVTREWFQILARQMFDPNYALFQPCAADKLTYQPNRASWVNPEHLSFFKFVGRVIGKAIYDGRLLDAYFARSLYRQLLGKQVDYKDVEWVDPEYYNSLCWILENDPSPLDLTFSVEADEFGVTKLVELKEGGASIPVTQENRKEFVQLSANYRLYSSIKDQIESLLAGFYEIIPKDLVSIFNEQELELLISGTPDIDVDEWRSATEYNGYTSSDPVIVWFWRALKSFNREERAKVLSFATGTSRVPLGGFVELQGVQGTQRFSIHKAYGDTDRLPQAHTCFNQIDLPQYSSYEMLRQQLLLAINEGGEGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PML9</accession>
    <name>A0A4Q9PML9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_681111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PML9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26593" checksum="AD1FA2C00E9B9D69" modified="2019-07-31" version="1">MAIHSAQDNQVPPQSPPQSSRISGLGICALPAELMLIVFQAVAPPELDPLFGVDVYRINLKRWLPLRLVCCQWRELVDTHCRDFWRAIDITGNPEWIRLCLAKSEGAGLELLYGRKDPTAVSLNSREGILALRSELKLSVVLPLEDTARVQCIRVSGATAVLQLDKLQPLFDKTLRCLETLDIRMNVLEAQHGVVLTEFLDIDGKRLPALRSLSLKGVYIPWKSEFLRDLRDLYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNC7</accession>
    <name>A0A4Q9PNC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_670827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="207" mass="22348" checksum="1BFE02042B7EB7DB" modified="2019-07-31" version="1">MKAPRTRTAARRTMRLANKDRAENGAVASHPRRANIHPVFSPGYGHTVPAPASARDKSSSFRGPRQDSELFFLLPFPDPPDNPYTHVSGRPLTVYSPDVLAFLFFSNGLQATATHRHAFQSLCESTSGIARSREARAGPAQQPIDYLDILGLIHGSEHPSDIASPSSPSRKVSPRCLDAESDTRKAHGACSLALARATRTTHLCAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPK1</accession>
    <name>A0A4Q9PPK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_632927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPK1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11907" checksum="76AA38D061E9203B" modified="2019-07-31" version="1">MLRCATIAVRLSQLVDALPSQHFQKTNRRPWPCDTCATASNFNVSRKLSKLSLAADSRQLENGSSRQRLTAALEWCDVIHGITTDPCQFGRCMRLNCGSHPAQGSGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPZ5</accession>
    <name>A0A4Q9PPZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_882561</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPZ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPZ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00299">
        <property type="entry name" value="GST_C_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="31"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="129"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="284" mass="32061" checksum="63D995578A705C8C" modified="2019-07-31" version="1">MPEKLHDSGRSYHLQCTGDAAETARAHSSKEAITLFGSCFCPFVQRVWIALEHLGIDYEYYEVDPYKKPAELLELSPKGLVPALRLNAHNPPKALNESTVIVDFLEELAVSNVKRSSHTTESLFPPASDPYARALVRLQADTIERTLVPAFYRYLQAQEEDKQIEGAKGFIEAIEGLVTLFKRAENEGYTEYGLWNARGSLSYADVMVAPWILRATNVLKHYRGFVWPESKEFQGYVERLLAHPAVKRTTSTDQLYLDSYERYAFNRPNTSQVANAINAGKALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ10</accession>
    <name>A0A4Q9PQ10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ10"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7724" checksum="106F9CC31043A2B4" modified="2019-07-31" version="1">MRSALPSASSHEPRSVHRESPRVPSAVYGAVSILADDAAGNVRGSRLRASLTVPALLDRASKSRLTVTRVTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQG2</accession>
    <name>A0A4Q9PQG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1040453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQG2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="348" mass="38904" checksum="8C43E9FA945863A6" modified="2019-07-31" version="1">MAAVANAMKYVRLGNSGLKVSRLILGTAMWGNPKFLPWSTIDEEAATEQVRVAYEHGITTFDTADIYCMGLSEKMLGNAIKRLNLPREEIVILTKIGLPMVDLEAPDPVKKYMDPENNGIINRRGLSRKHIFEAVGDALKRLQVDYIDVLQCHRFDTTTPIEETMQALHDVVKAGHVRYIGMSSCWAYQFHAMQNYALKNNLTPFISMQNHYNLLYREDERELFPTLKLFGVGSIPWSPLAKGLLARPLNAEVNTMRSKDPSLEKYKSAATPTTLSRVGDLAKKKGVSMAQLSLAWLLHKEGVTAPIIGPSSIEKLNDLIGSLQVKLSDEELHSLEEPYVPVPIFGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQZ7</accession>
    <name>A0A4Q9PQZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_823086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQZ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7551" checksum="6E86B7A8D19C1B0D" modified="2019-07-31" version="1">MPRRRCQHSLQSSFPHTCPDGHVARSWRSVQAQKGKNASIDFARPVAACNVFPLPVLCVLPSSGQHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRY5</accession>
    <name>A0A4Q9PRY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cryptococcal mannosyltransferase 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930154</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRY5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRY5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="331" mass="38147" checksum="7E1C3A5653D39AB9" modified="2019-07-31" version="1" fragment="single">MQLAWLLASFWVRRKLEQRSKGAEYREEGYMMLNGGGSGSMASGEEGWEDRDVRGHKSRGQLRNVGTIWLIHYEHPGDIRFRPALRKALAERHPSPQGYARGEKVFIAAAFHQNEQVLPYWTQTMLDAITYLGTDNVFVSVVENYSSDRSPELLREFASELDRRGVKNRILVQDETIKKPEKVEWNPRIEFLAAIRNQALEPLLAHGGYDKVLFSNDIFIEPESVIELLETRDGDFDFACGLDFGHFGAYDMWVLRDRVGHLTAGIWPYFFDTAGYEAMKKEDPVPVFTCWNGIVVFQADPVLPIHLRIPRCRHLLFQDILGRRSSDHRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU89</accession>
    <name>A0A4Q9PU89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_820081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU89"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="39650" checksum="55A91E9FB76443BC" modified="2019-07-31" version="1">MSLESSLELFCAVLVSVFYSAISYLLGRPFFGHRLSIGRLTLWTARDVHFEAALFSKTYRCSFRIPLIAWSFHIPRSVEPRWCTITLHDIFYKSPTGDISIGRFELVLWFFPVFFRQSTQPWGNVVIDDFRVLVFRSIQTPYYIHRLREKLVSALLTGDVMRCDMARTTCRFSGVSDLVSDGRYTTVPMRTSDKDEMCFSWLSRQLHIYNCDSRVYAFGSIDAQVRRSWSEDRGSFVMNAEELRWVHVPYPFEMVSPRGGLTQLFSSLFHFPLDLMRIIHSPSTSVNLLITRLDVRFDAFRIRDAEMLRQGLLLLREKAKANNIHWNDLFVDALAYVLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUR1</accession>
    <name>A0A4Q9PUR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_927399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUR1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="214" mass="24062" checksum="CFFBBA47214EAF8F" modified="2019-07-31" version="1">MHARCTELRNACADRRRREETSTMRWSWCLAPVSIQFLCLFVRILPHGRQSLEICRAPGLGCCVEVSTGRDIDGNLVCPGLASRRRVTTGIRMLSRCRIFWRGGSQVHIACLGLGISNSLRLGTFKVLLPPQMPLHPTALEGMLLSFCPAFLRPVRSRPGLRKPQAPRWMDIRLSRSVHHPRVSTFVKVQAGVGRTNRFRDPGPGRKRGVLSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUW5</accession>
    <name>A0A4Q9PUW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUW5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="414" mass="44348" checksum="B65B02ACEB9EF4BD" modified="2019-07-31" version="1" fragment="single">MSGLDEAVQDVTDAKQMGLDAFALNVQQPSPDFTTSSVGWLFEAANQNGFKLFFSFDMTTIGAPSDFLPLFNQYVGNAAYYQHESRPFVSTFDGGAKSFGASSPNQGWQQQFKDVLSGQGINPFFVPDFDDYTGSAGSTYDSTFFSNYGVVDGVFSWESAWPEISEGLVNVSDSKDQAGLQAAHAANKVYMMPLSSLQFKHIDSGQNWYRIGELNLPERIGQVLALQPDFVEIITWNDAGESHYIGNNWPEAISGAPAIQAYSNGYDHTSWQDVLAPFITAYKAGKTSLKDVTPFGAFAGAYWYRPLLKGASCSGDSLGKPQGWESAQDTINIAVLLPSNTSGTTIRVTSGGNVVANLATTAGLNYAAVPISTGAQKVELVDASGNVLGAGSSTQDVVADTSGTCNFNYQVVHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUX8</accession>
    <name>A0A4Q9PUX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_977608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUX8"/>
    <dbReference type="OMA" id="TIALMMC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="187"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="348" mass="38330" checksum="89D154F7B02BEF3D" modified="2019-07-31" version="1">MSAAPNDAGVPADPVAGFPQISVDNSLGAWLLGVAASLLLNGILIHQMYHYFSLYPKDRLLLKTWVSVVVVLETFISVLILHTAYFYLINMYWNPAYFFISPTVWSLNVLPIPGTIAALISQTFFVRRVWLIAPKFKVVVGAAFCLIAGNVVCFTVLSVKMFKAAGILDWLKFSWLASVGSSIQMGGDIILTLVLIYVLRKSRTGMNKTDSMLDVLIAYAVSTGAINCVVHILNVVFSIVWPDNLIYAALSCILTKLYANTFLVALNTRKFLGGIGNSDEQTGSYKFSANIPRGLSDNRINRPLTTTNTTPTTIELKVVTETQMIADDDELDQMRTKRSLGDHSRSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVE2</accession>
    <name>A0A4Q9PVE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_473834</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVE2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVE2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="130"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="306"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="695" mass="78466" checksum="AE51CC0D9D7AAF7E" modified="2019-07-31" version="1">MRVLETSTGRFVDVNPIEVEYAILSHTWSEAGEQSYQDVIQLHKSLERRRASIIRMAYAEVTWRFLVALTFLLHLLCIAISSRHLTSPMLCYVREPGRTRVARALRRYIEWLKIVASLCRPLDTILDNPMLSEKIRKACGVARAHGHSLIWIDSCCIDKTSSSELSEAINSMYSWYRYASVCYAHLADVPDGTVVTQGSANEVFRQIRWFRRGWTLQELIAPRIVIFVSAQWTFLGSRFALADLLQDITGIDSHVLTRQLEPKDFPVAVRMGWAACRKTTRVEDEAYALLGVFGLHMQPMYGEGERAFIRLQEEILKRIPDATLFAWGRTMHSTMALYMDGEDKFAENCQGYGPPLLSAAFDRETSFFARSPSSYQKRGSRSRYSPISQETLLARLGLSDGSAYPFTDYAETPYGTRLHMPLIAIDPEPMSRFLSSYGDDSFLAILAVESDDHPGYLIARPCFARIPGPSRTIRILRPGHITVYRRTPTSWSGGARETTSSFDIIPINPNDIERYRSDMCCEPIHIPNARPLPSFLGSAHGYNAEEANVALSPCSATILRTQGYSIMERDLDLHDSEDGATRRALIELSREDEVISIEYEYRMRTQSGPHMRADVQAARFPWAISLSGRNPRLPLFKPGKQIRGLRSPTSFVVNGPAGEHALVHLTLESSFRCPAQWLLDVEVTGAAILGRWGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWG4</accession>
    <name>A0A4Q9PWG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_926270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWG4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10233" checksum="5680E4DCCB552162" modified="2019-07-31" version="1">MYVVSSAEDGDTLGYIWKRIRCGRFSYCEDETLSDAHRIEIPISLRMRACVADSANWGPSVSFQITQVPPARAKVYREGSMMRSRALSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWU8</accession>
    <name>A0A4Q9PWU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_926279</name>
        <name evidence="11" type="ORF">BD311DRAFT_762723</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143447">
        <property type="protein sequence ID" value="TBU26340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWU8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWU8"/>
    <dbReference type="OMA" id="QWRWDTG"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU26340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11707" checksum="08FACB5927E12776" modified="2019-07-31" version="1">MKVKIKKWHAIAQWRWDTGHNDPDDDGEGDVCGICRVPFEGCCPTCKMPGEDCPLIWGECTHVFHMHCLLQWIGTASSKQQCPMDRRPWVTAERKVDANNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXK6</accession>
    <name>A0A4Q9PXK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_426525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="12284" checksum="9E477B622626A9FD" modified="2019-07-31" version="1">MGIVARSSMVFHAFANPSYRPREQRQLWSRRQSSALARSISHSEFVTLGTTIATTSPWPPELPSPRQQRHRRCSSPPSQQPHYHRKLVRRTPTRSQTGRPPDARTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXK9</accession>
    <name>A0A4Q9PXK9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_976665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU59270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXK9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXK9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
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        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020845692" description="Hydrophobin" evidence="7">
        <location>
            <begin position="22"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU59270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="13085" checksum="50B4ABBD48951AA9" modified="2019-07-31" version="1">MFSRAVVTLYFLLSLSILAAAKPWNTTPPPVTTTATATVTVTVSAPAPTGGDTCSTGPIQCCNSVGSASDPAFSGILGLLGIVLEGVEALVGLGCSPISVVGVGSGNACSATTVCCQNNSVGGLISIGCIPIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYM8</accession>
    <name>A0A4Q9PYM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PAN2-PAN3 deadenylation complex subunit PAN3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Poly(A)-nuclease deadenylation complex subunit 3</fullName>
            <shortName evidence="7">PAN deadenylation complex subunit 3</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">PAN3</name>
        <name evidence="9" type="ORF">BD310DRAFT_362229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal zinc finger binds to poly(A) RNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. PAN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYM8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3700:FF:000001">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.5160:FF:000002">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex subunit PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03181">
        <property type="entry name" value="PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="97"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Knob domain" evidence="7">
        <location>
            <begin position="377"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="338"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="239"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="469" mass="53320" checksum="A1004C714063B159" modified="2019-07-31" version="1">MSSANPYEMPPEHMLGYDGAAIDAYYSASLTYTRQPLNYHLYTLPRPEALAHKYFVSDDIREELQKRSETIHTTAPPGLGLPEEMQGYHTLVPLEPIGADRRKFGNWYSMVYRATSSTDGSTYILRRVENFRLMNQSAFGAIETWSRLRHPNIVSVHEAFTTRAFNDNSLVVVYDDHPNAQTLYEAHIKPKAPQFQNGRLQAQSNRISERTIWSYVIQIANAIKAVHDAGLAVRLIDPTKILITGRNRVRIGSCGIVDVLMHDLHSDISFMQQDDLTMFGALVFMLCCSNLAAMNNLQKAIDHLGRYYSADLKSVALFLISKGGPHKNIGQLFDMIGSRLLTELDEAQNGVDRLENELMSELENGRLVRLLCKFGFINERPEHNHETRWSETGDRYIVKLFRDYVFHQVDELGRPVVNLTHILTCLNKLDAGTDERIMLVSRDEQSCLVVSYREVKACIESAFSELSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ14</accession>
    <name>A0A4Q9PZ14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_816126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ14"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="4"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8061" checksum="611E61CCEF12D502" modified="2019-07-31" version="1">MFNVAVFLYDIIITTGEEIRCFWGRKVTGAAILFWMNKYMTILFLAWNFGSEFAPSKEVSMCSLGPHTDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q069</accession>
    <name>A0A4Q9Q069_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_947481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q069"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q069"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="490" mass="54493" checksum="567895296D16797F" modified="2019-07-31" version="1">MSTVLTILAAGAAVLLYALWWLFGTYFMRSPLDNIAGPTYKSISAQFSTETGRRQAWKFWENLAKTYGPVTSMKGILGRRFLVIHDPKALHTVMIKDQEIYVKGLAPLNDFTVLLGPGVLSTIGAQHKRQRKQLNPVFSAAHLRNMTHIFYNVAHKVRNAIRARVPAGGTGEALDVNGWMARTTLEMLGQAGLGYSFDSFVGDATDPYGESVKLFFPVLSRFQYFGLIIEKASYILSASQIRGLLRRYPHKDVRHIMQISDTMRRRSQEIIEEKKAALRKGDEALLHQVGEGKDLMSICLKANMTASEAEKLSDEELIAQMSTFILAGMDTTSNALSRILNLLAQNPTVQDKLRTEIVEARGGTGGETDTPYDDLIKLPYLDAVCRETLRLYAPVTLSGRMAAKDSVIPLYTPIRGRDGNMINEVIVTRGTLVLVHYQASNVDATLWGEDAYEWKPERWLSPPPAALEEARIPGVYSNLMTFAAGIRGCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q116</accession>
    <name>A0A4Q9Q116_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_777313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q116"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q116"/>
    <dbReference type="OMA" id="NACAMPE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="22537" checksum="674CF6CB64C3DECE" modified="2019-07-31" version="1" fragment="single">MPPSYSPCPRPCLKRSSAPHPLPSPQDEPSTLLAIDPSILSPLVRFPPQPSLAHTLGSAIPYDRTPIVVQPNRCALPARGCPGRTYAPEDPSLSNPRRSKRSSLSPVRGKHLHPRAVDERPHDDDPTPRQSPRDNFHPLPALVPDLSSSESSEESDGIASPPPELYHASSAYAKMSLEQSFVNLSLAGTNAPSTAALSFLPHPPSPRVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q197</accession>
    <name>A0A4Q9Q197_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_975480</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q197"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q197"/>
    <dbReference type="OMA" id="GATCAWQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020590947" evidence="9">
        <location>
            <begin position="25"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="34"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU60937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="219" mass="25390" checksum="037FAA4CE2050A9E" modified="2019-07-31" version="1">MATPRRHPLVSLCLLLVLAAVANALHFYLDTNEKRCFIEELPTDTVVEGHYKALEWSEQEQKYVENTNLGILVEVDELETGHNVVKTRGPSDGKFTFTSHDSGDHSICLSSNYGTTWFSTTHIRLHLDIVVGKTKPDTEQDRSHVSELSQKLRDLNMKLEDVRREQQYQREREAAFRDLSESTNSKAVWYTVVQIGVLIATCVWQMRHLKRFFEERKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q250</accession>
    <name>A0A4Q9Q250_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ABC transporter transmembrane region 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_921668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q250"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q250"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="511"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="770" mass="85356" checksum="E8E67AF07C8A10C4" modified="2019-07-31" version="1">MVIQLPNAAVLSSLSPNARRSSLVALFTFLLIRSRLVDIPKAAVSKLKTAASRQDVSQEELAQALQQVYIDEPDGSKTILVPHKGYISKVTISPTPPSVIAENGKRFSLIPASHKPNLDKTFLRQLFAILKIAFPSWHSKEALLLVMHSSFLVLRTVLSIAVARLDGRIVRDLVSADGKGFAKGIGLWFLLAIPSTYTNSMIRHLQAKLSLRMRTRLTRYTHDLYLSSAPDLRYYRVAIEGGLADVDQYITSDIASFCNALAGIYGNVLKPSLDLVLFTSQLARSLGFRGTVMLFVNYYVTAKILRSVTPAFGRLAAVEARLEGEYRAGMGRIGRESEEIAFYGGGLRERSILGRAYMRLIKHVNSIYKIRVAYEWTEDFLIKYAWSAAGYCLISIPVFVTRVRNVGVQTQGPRPHEKSDNEVANRTETYISSRRLLLSLADAGGRLMYVQKDLLELAGLTTRLYTLLSTLHNLPHPPLPDDPSQANIVLRNVDVGIPTAAPQLIAASESESTEDISLTESKAHATTVLVKGLSFELQPGEHLMITGSNGVGKTAVARVLAGLWAAQGGGDVKRPVGKKGVFIVPQRAYMVTGSLLDQVIYPDSYPDFVASGRTHEELMEILTAVNLAYLPSREGGWSTRKEWRDVLSGGEKQRMGMARVFYHRPKFAILDECTSAVSSDVEGRMYEHAKSLGITLITISLRPTLMRYHTQLLTVAGDGTGRWALKRIGTAEERMDLDREIVSLEDKLAEVEKWEKRVKELERLLSVQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q258</accession>
    <name>A0A4Q9Q258_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_874005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q258"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q258"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="61208" checksum="55C3833728D50DD8" modified="2019-07-31" version="1">MALSLPIAAFVAAIGFVIWRFFLQEILLPSSFNLKNIPGPASHSWWKGHLDRLADRQSFNYWKEIADTYGTVSALRGPLGSWLLYISDPKALYTVLIKEVENYPKRITPSDDLNIFLGPGLLTTEAHQHRRQRKLLNPVFSAAHLRHMTNLFHDISHKVRGAIHQRVAQEAQIIDVNGWMARTTLEMLGQAGLGYSFDNFIEDSSDAYGESLKSFFPTLARILLMGFFLPGVSRVISDDTIRAILRRYPHKEVRNMMSVSDTMMRRSQEIIVEKKEALKKGDEALTHRVGEGKDIMSILLKANMTATDAEKLTDEEVIAQMSVLMLAGMDTTSNALSRTLQVLAQNPAAQAKLRAEILEARNGEPTVDYENLIKLPYLDAVCRETLRLYSPVQIIARRAAKDQMLPLSKPIRGKDGRMMDAVPIPRRTLVLLHLQGSNYNPELWGEDAHEWKPERWLSPLPADLDEARIPGVYSNIMSFSGGTRACIGFKFAQLEMKVVLSVLLAAFEFELTDKEITWNSAGVSFPTMGLNSEKTEMLLKVKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2J5</accession>
    <name>A0A4Q9Q2J5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1037449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PheA/TfdB FAD monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2J5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012941">
        <property type="entry name" value="Phe_hydrox_C_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038220">
        <property type="entry name" value="PHOX_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07976">
        <property type="entry name" value="Phe_hydrox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Phenol hydroxylase-like C-terminal dimerisation" evidence="7">
        <location>
            <begin position="511"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="563" mass="62087" checksum="BC6C24987706245A" modified="2019-07-31" version="1">MTDTSRILPVLVVGAGPTGLAAALTLAQNGVPVRIIDKEEAFHATSRGAGIHPRSVEIFHFLGVLNDARKFHRDLPPFQSYKLPGGTEVLKRWHLFDKFESSPDRPWDAMTISQYYTEGVFRDHLAKHGIHVELRTEPVSMEQDDEGVSVTLKRVDGDGKEQTESVRAAGKIEGLSDLSGITRKQIGATFEGETKDADGSVYADAVIEGLSSELWHLWSTPGKMLIGARPKLEPNAFHVTIFSRDFDPVEMVDQQKFVDFFHQTTGRKDLHFKEITALTYWKPKMRMVNKLQEGRIFIAGDAAHIHSPSGGQGLNTSIQDSFNLAWKLALVYKGLASPDLLGTYPVERLPVIAQMLATTSNLYTHLIPKKEDSQATTVQDQDPKKAGFMQWRNTALYQLDINYRWSPITVDAHGKDGLSEDDLKARAYEGYPGGDVRAGDRAPQAPALVGADGLEKTLFDLLKPTYHTVLVFSPQGGAAEIVKAAQEYPVGTVHTVVLGKDAVPQPIDSAESYHDKEGHAYRAYHVDGGEVTVVVVRPDGYVGAVVHDVDGLRTYLAKIFRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q322</accession>
    <name>A0A4Q9Q322_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_975148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q322"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q322"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="244"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="804" mass="90344" checksum="6E06980348396936" modified="2019-07-31" version="1">MKLLPPERRSTIDDILNWSKTGLEWGKHITSVFPIPGGVLSPHLFALVLNTSFGQSQAARTNEEDVESLLIELKQLAEVVGKSKHDIDDHIESTLEKDQVQGENALQSPREVEDHFKKFEFDLRGLSDQSKALKHSNFLPAWLFSSRDARTISKIKSDVAKAREYFETSCLVAIQTWLENIDKKLQHITVAVTDIGDRAEVERREDADDRILDALPRADAGYNSSFNQLKGRFLEGTRAKLFEKLEAWIEVDSSHKPICVLTGGAGTGKSTVAFELAKRLDERYHRLGASFFFIRGIADLDSTRLFFPTLAYQLAHSQDVLRKHIVDSAREHLKKGRTQAMEREAPALLHNPLSLVGKQDPPIFLVVDAVDECTEDPVKLVQEMLDFLMATTQHGPIRIFLTVRPVRPIEAKLSSAKWTTDVHTISLETSSNDATADILAFIKDSFSRIPQGPELLKKRGDIAYRLAQQAQGLFIYARTAIDFLETYPGPLEEGVGFLLSDVAEEAVALGPLDQLYLVVLENAFPPAHMQQLVLRARVQVVLGCVAVLRNPVSPRILEKLTLPTRRTITCQDTVSVLDRLRSVVIFENGSVDEAFRPMHATFSQFLVDPTRCTNALYLVDTQRQHAHMADACLKAVLSLEQNMCRLEESELEGSIQDIADIESRLIHVPQHVQYACVYWVAHLREACRPLTHAGHGCFCGDLVVLLENFVANKMLQWMETLGLMGRVDGAMDALGAARDWLPREPQYTHIRERINHGRQILFNHTDGIRNCPHSVYKVSTQEDGDFTLNAILRHRPAIVSDYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q372</accession>
    <name>A0A4Q9Q372_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_178364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q372"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="19479" checksum="6A7BA83495726FB9" modified="2019-07-31" version="1">MATSGAATHVPIIPCPTFPWTSLLHCTYCLHLLCIAVIRITSCPPAARCTPDLPVRQPSRRQLAPVRFLQITRGAPTTCDEECTSIRTAISPYVFASGSSMLRRLGCGSLASCSSHSCGPLHKGPAIACAIAAEDRALQHGYPRAVTRLMLRSTYPQAGDTGVRGAPERSNSHGGQRPSLRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q393</accession>
    <name>A0A4Q9Q393_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_845241</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q393"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q393"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="13">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="12">
        <location>
            <begin position="193"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="308"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU61619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="465" mass="53676" checksum="FDA34C4EC7774BCF" modified="2019-07-31" version="1">MLIQYLFVFAQVHEDFRIPELLSTSELYGFEIKFPERLEDRDTSRPFMLLELESEEHARLLSRRCILIRYVCEFYARGKSYEEVHEHNRARSSLWEKYIEDTSFKFLVTAFNHTIPQWRQRDVVESFSYMDFRGKIDMKNPDITLTVFEEYPDKHGTTREKTEGDGQFDEVWFGRLIEVGSARPLVKTFDVKKRVYYGNTSMEAEISLLMANQTLASPGKLIYDPFVGTGSMAYTTAHFGAFVLGSDIDGRQMRGKIKPPGIIRAAAQYGVASRIVDLCTFDVTQNPWRCGDLFDAIITDPPYGVRAGAKRLGRKSNRPPREAPAPAHVERPDDQPYIPPVKPYELSELARDLVILARYMLKPRGRLVFFLPTVTEEYEELDVHAMLCDGMELVANSLQNFGSWGRRLITIRKTTAEKYPPPIFDPVRAVTEAMDVHVPAHKDFREKYFQGFKKSDFSIEDVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3H0</accession>
    <name>A0A4Q9Q3H0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_873047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3H0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04434">
        <property type="entry name" value="SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16548" checksum="CAC446D80EE097ED" modified="2019-07-31" version="1">MASAELTTILNQVLEGLTADTIDESLEKLRFFFPETLLLGALDLIDRDSGKPSTIRIPYIILYKTPWGRPQYEVLGSTATYIVFPGLPSVATATAYCTCPAYAYSVLLSETQIMCKHILATLLALRLSRCVERPVTADELASMIARQCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3U9</accession>
    <name>A0A4Q9Q3U9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_812380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3U9"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14143" checksum="3B87DF874E428DFF" modified="2019-07-31" version="1">MTLGLRLWRFVSLEDRVIFLIFSQGRREHSALASLPCAQNRVNSDLVASRWVISQKNVRCTRSSGCQCTSSQRLVTSSSWSSDVLDYAPTDALDGSRVLVFLLETARGAAAIAQKPREEPRKRRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q488</accession>
    <name>A0A4Q9Q488_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_813016</name>
        <name evidence="2" type="ORF">BD311DRAFT_659781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143408">
        <property type="protein sequence ID" value="TBU30127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU61434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q488"/>
    <dbReference type="OMA" id="CKNASGW"/>
    <dbReference type="OrthoDB" id="3229660at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597655" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12080" checksum="45EE52B27F4E6E3B" modified="2019-07-31" version="1">MQFTIATIVLAAMLPAALAANCQNSGGVANGECVKFYSNDQCKGGAIGSYKPTCEGNCFQGSFSSVEVSGDGTYGTDCTIYSDSNCNNEQTETGNSVAGAGKCGSSPNAGSMKCYYRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4C4</accession>
    <name>A0A4Q9Q4C4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_919514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4C4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4C4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="271" mass="31343" checksum="506B7EC2521EC564" modified="2019-07-31" version="1">MNLSAALHHEQHNEKHQAKVQERLHDEWFWNPPVDWGPTPIPLDSSPWEQAYPSERAEEFINHWLDNIAAAQRDEAPESMDTFIDRYNQKYQDWNDNGKPSEEECGEEKNCTEDVDPDREVDDYACKGIPGKWYDVDSFHPDEEGFDVVGCYSAAVKAGIYKEKQWRAPAVDTEPNMWLVEVDLRQEYLAWGFSPEQYAARHNSADTPPSQPERPRTEAQDAQPSEWRTVNRRKSRGRRLDNGGVQGQKSGIVDGGKRRPRGRRARRAKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Y3</accession>
    <name>A0A4Q9Q4Y3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_871129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Y3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4Y3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="848"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="900" mass="95645" checksum="F2C3904DE9ACF339" modified="2019-07-31" version="1">MAPSSLSASSSSMVSLTDCTDDPAIDMLPTPPSTHTSRSTSPACPALGPDADLLDADTQEAPSAGKKKKKKKAKKAGAKAKESANGTANDTERDRPPVLCISRNKHWRYISSYHGPWLQLPLELLESLLLLNVDPATLSAADSKLPPLPSHPSAHPHLHTNGHSHRHNHGHDHGFGHGHGHGHPKQRDRGFASLADYSPPDSPRNAFAALPAPYPFPAPLPGQATPPPIDPGVFRSVTHIRRLIDEAAELSVRASSGLSAAALGSMRGAGTMNGSAWATAQSLGLGMNPLGDGGGRNVAMSAMRVHRLRALAVQKLAAAYRTDEIASSVMVMQGGSVFDDIAERVLKVDPNDVDARYVHFFHEKIPSRQLAESTSTQVLDELIATNPHRLEFYRTRGIVHCFRDEYALAAKDFTHAIKETRVQRKARNAHLGSNLSDKQRGKGTKKKKGKAGGGRTNGQAPPNGTSASTGGAEGLSTEGSDGDGALLHPSVLPDAPDPIEPQCLFLRAAAYLQHAAFLIEEAIFKVEGIRKVPSIDGAEMRLCYVENARYGGTEIGNPDGPLGKADGPKLQAYRAVFTDAAFRETVLTLVKKSMRDHKQFLAHFDTLEGPPGYADADIAQRTEYAFLLSESLRPGSQSAPPPAPDTPPMFTTYHPLLVESHFSILLCFLMLGDFPGLLPAFSRTAALVDGLEGYPVFLPPRSMAQAEFIEILERLAGGWRNGVQPHSLSRANSKQLAIEAPPRSPRSPKAKEVNRIPTPPSPELGRSSAGSSGSTHLLGVNGSSSSSGTGSGSSAGSSCGAAKGPHLQPLPSPGPPADGEPPRRPEELYEALDAARILLAPVVKRQREKAERAAAEKGGKGGGGKSKKPLNINIPLHGPRVEIVLAWMAAVFLCELDTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q560</accession>
    <name>A0A4Q9Q560_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_811851</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q560"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q560"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="3">
        <location>
            <begin position="171"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="636" mass="69757" checksum="8C679EC242198C73" modified="2019-07-31" version="1">MAEPSTSSSRSGASSRLSSTHVGRSEATTLDEPSERPVKFTPANSFDLEDHQLASQSSTRTVPWGSRFRAFVAKHQRLQRIWLYIRGPRPKSDLPDPTPWLNFHLYTGRKQYGVALEPALIRCTRPLTHPWLFVILAAGYIIGFAFFARAQSFLTPADSFIGCTATYWAALDGCGLDGVNCMPFSNSTFDFRCPAQCSSVVLQNPRTVGDEQVDFVPLIVGGGDADHTYRGDTFICAAAEQAGLISDRKGGCATLELVGNFTDYLPFTAHGLTSIGFPSVFPLSFRFLPTTSLHSCSDLRNEALAFNVLITALIFIVLRPKAIVAFWCLVCIGFWHVALFSQPMASPPPLDDAFQQFLPALFVAYAFWRLAFRFTMPAFRKAPIEAAVWYLGPFWVGVLTNITMDKIPIDRLTASDITQRPGGLTALIIIVLILLAIVINQVRVIRKTGWLPHYLGWYIAGGLVVVVLSQLPGLELRIHHYIIAMVLMPGTGFPTRLSAIYQGFLLGMFLNGVAAFGFDSVLQTPADLQRDAPLGSDLPAFVTNSTTYNASIPLQNQTIFWNSIPDGENWDGFALLVDDVERYVGSALNYSLAALQPGIIHFFRLAFTSGGTAGDFTKAATLYPNGSWVDPLPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6X3</accession>
    <name>A0A4Q9Q6X3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Proline iminopeptidase</fullName>
            <shortName evidence="8">PIP</shortName>
            <ecNumber evidence="8 10">3.4.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_809676</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8 10">
            <text>Release of N-terminal proline from a peptide.</text>
            <dbReference type="EC" id="3.4.11.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 10">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.5" evidence="8 10"/>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6X3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6X3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005944">
        <property type="entry name" value="Pro_iminopeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01249">
        <property type="entry name" value="pro_imino_pep_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43722:SF1">
        <property type="entry name" value="PROLINE IMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006431">
        <property type="entry name" value="Pept_S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="11">
        <location>
            <begin position="33"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006431-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU63115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="35059" checksum="5CBE4DA6E2A1CE46" modified="2019-07-31" version="1">MYPPIEPYETGKLKVSDIHTLYYEVSGNREGTPVVFLHGGPGGGTDPKDRSFFDPTKYKIILFDQRGAGKSTPTASLEDNTTWDLVKDIEKIREHLGISKWHVFGGSWGSTLALAYAETHPAKVKSLVLRYVFRTELRFFYQDGASHLFPEAWEEFIAPIPETERGDLMLAYHAQLNSTDDETRLRAARAWTKWEFQTSKLYVDPAHVAEAEKDDFANAFASIENHYFVNDGFMRDGQLLDKQEIDKIRHIPCVIVQGRYDVVCPATTAFALKKVWPEVTLHIVPDAGHSSREPGTAKLLVKATDEFAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAV1</accession>
    <name>A0A4Q9QAV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FMN-linked oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_868913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAV1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="424" mass="46928" checksum="4FD78C498B02EC1F" modified="2019-07-31" version="1">MSYINKRVPGADQFFPLNDPPIGTAYSKDLYPQNAELPTLFKPITIRGVTFKNRIIVSPMCQYSADDGHATDWHLVELGGYATRGVGAICVEATSVVPEGRVSPEDVGLWKDSQIAPLKRIVDFAHAHGTVIGVQLGHAGRKASTYAPWVHSDFAGTFRAPKEVARKHEGGWPDNVLGPSDIPYSNQYDKPKPMTEEDLQHAEDAFVQAAERCKQVGFDFIEIHGAHGYLIHQFLSPLSNVRTDQYGGSLENRLRWPLRVAQKVRAVWDKPLFYRISATDWADTPEQDANGKWTQWGIEQSKIFTGELEKLGIDLIDTTTGGIWEKQRIDVGPGYQTPFAEALKKAHPNLAIGTVGLITEAEQAESYLRDGKADVVFIARALIRNPNWAIHAAEKLGVAIKPANQHERGWAKLLTPARAGVTKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC04</accession>
    <name>A0A4Q9QC04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_835898</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC04"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC04"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="69"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="266" mass="28944" checksum="5F2D738B7A27A84F" modified="2019-07-31" version="1">MMPPRAYYFIGLNAVRALSIIALILVFASSIFVLVNDIQAVNRAMASPQDMTNCDYIDGSTVPNQPAGVFWAVVNRLLIIFQVIVLILSEIGWPAAFFAKYFPVLGPDFGLGALGIFQCLIGATILSHHVDDFTVVAAFFLFSLGCINIFLGLFREKVKRSRSIMSWREEAKGVLPTHKDLRPPFARPASAFVGRVFGHGEKESDGSESKGLGFGRQGEKAAGLKGFLISKPLESLPRYATQPPRSDQGSRAGTPEPMFKSSATAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC70</accession>
    <name>A0A4Q9QC70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_4673</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC70"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="521" mass="59192" checksum="F57F6C4E703090B9" modified="2019-07-31" version="1">MESDTSSVNEKRSVNGAQPLEKPHVDTTNVDVAAELTAGKDFVLDPAEAARVRRKIDWHLMPLMCILYMMQFADKTTLGQSAVLGLNGPKHYIDKDQFNWLSTAFYLFFLGFEWPQNLALQYLPVGKWLSFNILVWAIALLCHTAARNFAEFFVCRAFLGICEGAITPGFLIVTSMFYTRQEQTRRVGYWFLMNGSAIILLGLVAYGTLHIHNDVLQPWQWLMIITGIITFVVAVAFWFLFPDSPATAWFLTPEERIIAVERIKVNQAGVENKHFKVEQFVECLMDPKTWLFFLFAAISNVTNSLSNQRQLIVQGFGFNSLQTTLLGCVDGVVEIIVIWCTVTSATYWKNGRAYSGFLAYCVAILGSILVNTLPSSDRVGLLFSYWISITSIAPFVVMLAWVGSTTAGHTKRLTTNAIVMIGYAVGNSAGPQYWKAKYQPRNHVPWLILSICWAVSAVLLLVTRFYFVYENTKRDREPRDTKYDEVYISQTQKDGTVVEKKVDKEFLDLTDMQNRDFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCI7</accession>
    <name>A0A4Q9QCI7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_806530</name>
        <name evidence="3" type="ORF">BD311DRAFT_656173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCI7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCI7"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU31623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19760" checksum="B5CB8D8EF8603C1A" modified="2019-07-31" version="1">MAPPKRAQCQVCESTESKYTCAKCSVVYCSVPCYKQHKVPSTSDTDVSIGDAGPPLRSLASLKWPYVPEESAYPDPLKRDDPKPLQLPQYEAIATSPAIRRILGSNPRLRETLISIDKLRGEDREMALEEALGIGGSRNNALTSLGTATEEDRKVLRELAEAVEGAVRGGKQDMLGLDWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEV0</accession>
    <name>A0A4Q9QEV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">HIT-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_836989</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEV0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033699">
        <property type="term" value="F:DNA 5'-adenosine monophosphate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990165">
        <property type="term" value="F:single-strand break-containing DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000012">
        <property type="term" value="P:single strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486:SF4">
        <property type="entry name" value="APRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12486">
        <property type="entry name" value="APRATAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11969">
        <property type="entry name" value="DcpS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT" evidence="14">
        <location>
            <begin position="9"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="244"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="11">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU65786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="295" mass="33235" checksum="616783A8388A23F1" modified="2019-07-31" version="1">MAHLTILRTYAERVDPNTLPPTVKLCHSDFSVTIFDKYPKAYFHFILIPFIRPPLTAANLKDIRSLLQLPREQAKGLLRNIRRDALEAKALIEEEMVKQRGFKWGIQMGFHAVPSLEHIHLHIMSTEFRGEYMRSKKHLNSFHPTVGFFIHLDDVLSWFDPGVEPTWFAMKSDIVKKEYEKLLKEDMTCPGHCDKPFKTMPKLREHLREVFDSAAKASKAAKEAAASADVPVNGALEVNSTQTDDAEFVVGTKRKHGDALDATSSQDADPPLSDAPHPAKKQATGSPSEDLPQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K417</accession>
    <name>A0A4V2K417_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_956147</name>
        <name evidence="2" type="ORF">BD311DRAFT_666777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143440">
        <property type="protein sequence ID" value="TBU26793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K417"/>
    <dbReference type="OrthoDB" id="3228420at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU26793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15706" checksum="D0E5386164234D87" modified="2019-07-31" version="1">MAETLAQHSPASKQQSSIYISPLATHITSERAVKVGGRRLSISSRSKPAAPTADTRKTSPPAADTAPDYPRPAAPGEQQELHQQQQEEDVPKKKQGTGGDEHERRIQESLYRKAEQNRPKKEFLNGPKTTQRVNQPAGKSFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K457</accession>
    <name>A0A4V2K457_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_830670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145223">
        <property type="protein sequence ID" value="TBU53149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K457"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF3">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="675" mass="71805" checksum="02978EFC8194E3E3" modified="2019-07-31" version="1">MDPDAPEEQQFTFRAVFVGCALGAVISASNVYLGLKTGWTFGASLFGSIFGFAILKSMSKALPDRLGGGYFGPKENICCQSAATAAGSLGLLFTSGFPAAYQLGLLGENPVADYGRLITFTLGCAYVGIFFTMPLRRLYILKLKLPFPNSVAAAYTIRSLHVGRHAAANARKKTLALVTSFLLAIVWRVTSEYAPGIMWDWHWGWWFYSAGWKWIIAAENWGWIWEWTPAFIGVGLLVPLTSSISFVGGSALAWAIIGPALVATNVAFGIPATKTGEFPEYLNYANMVLDDPVNAPSPKYWMIWPGCAVLLCSSLAEIVANGGAVLRSLSVGFGPTAEAVKGFILRKPREGGYTDGAKVDEFPDPAPLDEQTPWWMWTGGLTIGSIITIIIMRYQFGQNAGVTILAILISFIFSLIGAECAGRISVIPVTTFGNFAQLVFGGVSKGMGVAPAANQLNNGLTGMITLAVSEQAADMLGDLKTTHLLGASPRVQLYAQCCGALVSIFLSAGMYVVFVKAYPCINELSTTTCAFPAPDVGAWRAVSVAVSSPSLPIPRSSGITALCLGALTIISTFVKFQFVRPERRVWFPNWNAVGIAFILGPLCTYPMAMLFGSLVALIWRKHWPVGAMMYCYAVAAGMIAGEGLGGIANAVLQIAGVSGAAKGTSVGCPANVYCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K606</accession>
    <name>A0A4V2K606_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxalate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_661520</name>
        <name evidence="6" type="ORF">BD311DRAFT_652261</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K606"/>
    <dbReference type="OMA" id="HWHPNND"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040684253" evidence="4">
        <location>
            <begin position="20"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="137"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="312"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU33559.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU62970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="470" mass="50126" checksum="78FEAC28C97D52E4" modified="2019-07-31" version="1">MLAFSKVLCAILLAGHASAAPAANSSAVSSVASLSLTSEAVGAAPSSTANSASALASGTSSALPASETVAFASDDPNDILWSQNSTTNPQPIRESLGAKILGPQNIPVALQNPDLLAPPTTDSGNIQNAKWPLALSHNRLQTGGWARQQNVDVMPIATSMAGVNMRLEAGAIRELHWHKTAEWAYVLKGSVQVTSINSDGQNYLATANTGDLWYFPPGIPHSLQATNDDPDGAEFLLVFDDGAFSEDSTFLLTDWLAHVPKEVLAKNFKASISAFDHIPGEQLYIFPSAPPPADSKYIVSDPQGQVPNPFVFHLSQVNATKLDGGSVKVVDSTTFTVSTAIAVAEVTVEPGAMRELHWHPTQDEWTYYLEGTGRVTLFGAESNARTFNYQPGDIGYVPASFGHYVENAGNTTLRFLEIFNTDRYQDISLNQWLALTPPEMVKAHLDLDDATIALLSKTKYTVVAGSPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K677</accession>
    <name>A0A4V2K677_9APHY</name>
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        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_834930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145359">
        <property type="protein sequence ID" value="TBU51223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K677"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="345"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
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            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
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            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="378"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU51223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="378" mass="43478" checksum="A9C95B6EDC1A3F74" modified="2019-07-31" version="1" fragment="single">MARTVADMPMRGSHKAPRTFKGHAHRVKDFLDEYETLLKHNNVTDAAQSCKVIMHYCSHDVREILETLDQTDWDTMKGQIEKIFDAEKPDRRYQKKDLSEFTRKAKVKPMTSMTRVRNYQREFQKIAGWLKKKNHITDDEYNKSFWKGIPKNVRGRLELSYVAANAVKDFSKPFVVDKVITELEKMFGRNRFNIEVSDSEDEDSDDYSTESDSENNNSEDSEDSEAHYKRRSTMRKALRCAQKKSRGTKLAQPDSIPPVEPVSQPLHTKQGRTGHEDLGDIENIISRLQNMSLDDPSYAALYYRAFKMDKDITFVIKPPKDTGFRGSAPSQPSPPRPTARTEMTCYGCGEVGHGMYVCPLNDLIVKGVLKRDSDNRYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6K7</accession>
    <name>A0A4V2K6K7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_225146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145245">
        <property type="protein sequence ID" value="TBU52593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6K7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14471" checksum="ED072F24993F99A0" modified="2019-07-31" version="1">MGHAARAIELLNCICAQSPCFPWAIICSSGCSRPISRSGTIPSSNLGLPYNRLHDYSTLCVDERSRRRCRTLPRSRYPLYAGYVCFMVARHPAGPPISKLRCGQPTLSFTEPDCKLCFPNKEALTNVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6M2</accession>
    <name>A0A4V2K6M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145240">
        <property type="protein sequence ID" value="TBU52713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6M2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22626" checksum="047E62C1D6BCAD93" modified="2019-07-31" version="1">MNYTGISIEAFLLLPTGRHCARYASLEPPPRARPHDIAAPTARVSLPPGTPTQPPEHDEPAQIPPAWTELRARHVPDAPRPVCVVRAEPEPRHARRHLLDAVLPDSTVALRFSGELVARLEAYDAVRMPCLRHVTPHGVTGSYFDRHPVDRCFPDAHLESFLHALRVRNHHLESLAASYGPRLRKLVRLGCSRLSSTVITQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6S7</accession>
    <name>A0A4V2K6S7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein UNC80 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_830251</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145216">
        <property type="protein sequence ID" value="TBU53383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V2K6S7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034703">
        <property type="term" value="C:cation channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005261">
        <property type="term" value="F:monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055080">
        <property type="term" value="P:monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046460">
        <property type="entry name" value="UNC80_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781:SF1">
        <property type="entry name" value="PROTEIN UNC-80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31781">
        <property type="entry name" value="UNC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20262">
        <property type="entry name" value="UNC80_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein UNC80 C-terminal" evidence="2">
        <location>
            <begin position="1202"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="892"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1932"/>
            <end position="1966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1983"/>
            <end position="2056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2144"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2028"/>
            <end position="2052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2169" mass="238922" checksum="DC5A677662BC99F0" modified="2019-07-31" version="1">MKAQRAEPVIHNTLGSTLHLPFLASSSNVSSATAGNGGSGHPRQATGGGGLRRPQSVMSLGVSSRAAPTVTHIARALTSSTSVNRPKTLPCETQVLAALLVPFLGPHSNEQVSVEQQTAVETFEYAIRTWKAASHEAELDRCIWCCKAASVYSRSRMRILGSLSNILFSRDRTFQVETPAILQTLLQCLFSLLVVLRSSQDSRQEADAVAAYIVGIKSGQSGTPSPQALEKEYGVRHKGDSDEHVREIIAAESVIGCLEVGSEVLRRWTLHNLVEEHWTSSDSQMLLSPLLTTMTWRKLRTFVNSSVSLLLNGSLDPRQNTYDADVVIHLLRTRILPEVEAMQDDAFAVVGEIQSSIIRLVLELLCIRGTSEREWVMLYFSHWVQEGGKWRESVERSLQNLIGQGEWPTILRLMPILEELPEDIRVSLIPDLLPAISDRLTRDPPERSCAPLSDFLDSAAISCPKAFFKPVFGCAASMKDLTIANHLCSLYSVARFYPGIWTHNPEMMSVAIMMDPTGSRKVTEPTGAAPTQGRVRIGQMVIMVELLHHLRRMRQLKDPAAFTVTHKFVVSLEARLGMLIEAKEQNTLIPASQRLLFCALFRECRLFTRSLRSAAWLPSVANWTSSYLFDANTDPDHELNEDEAVSTLSKLIALYSQAKAGLGGGGKRRTTVVGPTGVDTQQGKTAFQSGSIDAYQDSFDSRITMLQSLIDRRVSTALDLLVTVSGLLQPDDYMRLGPILWYKHLDNPEPHVIAPTCFLVMQCAEKIPTEFSVLINQDLSSAEVSMRRHAVQRMATMASWRFQLLSQEVILDKNYRRPFKLTRPPVLFVPTDIGSNLFELEEDPNDFKDSKGHVLPLELRRRLNEVGWAEERGEMDPKTEWIKTPMTRLPTQQLDSLSSSPDAAATTFQSQSPSPSPEPSPTRASPRESPLSRKDSSVGQSRAKRRPVFVATLVGFFPKLAAMVKDSDFVVANTARNLVLDLMRDDPQLLCRSVFHELSGDATGIMSAITTLRNFLHCEFALPPGAAHHMLNHVVGFLKGLMRHTESVDPLLGFGYSSPIVAKLAPQVSKMSMRDIRRAKVDTLLLPSGSLWWNDAPQPGPMFPRALESNYDPFDALPAPVVWVTMVRTAQNMVFLNLLRQNAQDVKIFRKNLTTLVLPIHFDDLHQNSIPLTAYIPVQGLPPAPTNPTLIALSLTLARSHLLLLHQVFRSMSRHLNDREELALLLDGLNRIMLAHGDDVGIVSHAMLNYLIASTRFRRLFTSGGGYTMFMPAVIKVYCEAASQPTIRAVIEFAVNRFFALHQESFIFQTCDVMSNVIALPGVDGSYVCRNIFALLATLKNSASQTNSEVSALSALTKLEEQEAILVTIAEKVPQVFLASVHRSAQDKNQLTVDVPDEFDSKRLSLDDLVRLFLTVIAHNPTILRAQQFLRFLMFLSPHLYHASASARSVLKDGISALASILLNKGIAKPKTSESASLVDELGSNAVSQTGLNQANLPQSSVPSDLLAMRLDLLSLVVGYTKAGGTLSALASQRVLEVVKVILKDSKSSVLRVAEFLADYVRAILIRPVHPELKQVVTLLSDVAPIISSYSTTVDFSGVFDVVTSLASDTVFANQPAFSRVLVNQYCSAGLEACEVAASENLLWTLTVRGSILDLLDRSLLVIGADVMSELEKREPTYEFLSGIILPFVLRMKATVEIASNSQWADKWRRDVYAQAWLRLIAYVLNVIQRADYIRPDSRNIIPGLDRRKSTDSRSLSSTPDPKPAMALVVALQILKVITTRAEQELSTVFPSIWGQIGDVLKETLADGDAGFAIPSRGGYSEPPSPTHSPRTSSFNIGADDGNPFLTPSMAPSAHRTRAERRPRIIDYMTWSLIEWLCLRRTPLALQMRVFIQEKVALLHQELIVNGAGNQSLTASPIISAMGMPSGGLNAPLTARGRPRPVSNIFSKPRRSFLSGADPSSAVSTPRSSTLFANAVSLPSFDEFGMQSSTPRKEDGPGRQAGYQLMPSPLTPSRRAARESGPKIVHLGPVRPLSPSGGGPRRSFSPSGQRSGIESSRSAFALAREMVVESPVLVRMTVRRIRVAQAMLGYPLLPLANVSSMDSSMTDMNGELAETEGLVKAWSRAEAVEMLMQETKDLIEEWRDDEGLDGIGDDSGVLVDLEEPRSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7G5</accession>
    <name>A0A4V2K7G5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1040761</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7G5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33606" checksum="DC41CE484B1BAAAE" modified="2019-07-31" version="1">MNSILVIAESDHGIRIASAIAFGILYFDYTLTYSAEVERFWKGRFSFASFIFYFNRYLALFGHIPVLYEFYGTHSQEVCSRVQMYHQLLAGITQVIVAGLQLFRIHALYHGNRRITSALSCLCLVCCAISAWAVSQAWHQPSGDKTMAGIPGVGCDLTMTEAQGKYLSFVWASVLAWDTTVFALTVYRVLGSGSRWRGSLMGVLLRDGAFYFAVLLVCHMCNILTCLLAQAVTRGISVTITNVIASSLITRLMLNLRDPRLLRNQSSGVTELSDLPWRANTGPHGSSAKSTGTSSHETSEGGSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7K1</accession>
    <name>A0A4V2K7K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7K1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17619" checksum="C23C30EFB17F2905" modified="2019-07-31" version="1">MHRRVTGHVIPTRLSSPPSRSWSDREQYIHVLTISHSTGSTPDSSASPTTSPDDPPRSTPCRESMRPPGRHSVGILPSLGKVSVYTNVVAGRAQTRHPLAFTSERLTIIEEPDDSAVARDYDVKEFSPAAFEDLAEPGRPRPRCTSRTTVFRGSNWRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7U3</accession>
    <name>A0A4V2K7U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_767985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7U3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="163" mass="18675" checksum="C89A2E17D75AE3EC" modified="2019-07-31" version="1" fragment="single">VYNHNRTPEEHRANNLVRRQATPADAERSIRQLDEAYRRATYQEGLLLDRPVAPTPQRQATIERIRQQTLDRIGRTHARAVLHSPVWNEYCLSVGSWAPNQASLEFTILDELEHWVLRDDGYDADDELPSLVNTEQESSAGNPSSPEPLDIFSFLTRIRDNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8D6</accession>
    <name>A0A4V2K8D6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_905822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8D6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="533" mass="58047" checksum="F3E26A8C6687A920" modified="2019-07-31" version="1">MGDLRPPELGLGPGRPSRTGGLYSCDLRFPGGYQHPIPWVVYACIEELNRTGIYEQGLFRAVPNRSRLDKLVAVFDRPTSLFKGPESGPLCPPCTPTPSNTRASLRKESTADVCALLKSYLDGLPEPLLDESIIIALHCLCVVPSELREQQTSGDEKLHHPRPVHGYPKGSAHFLAPSHASHPLRVSRSRSRACSDTASSSSASQIWMTPSEKRFAEASLEDIQIRIAQHLLRLATPPLCSLFAYLSGFFVLLLLCPDNGMALEDISRMFGRALAGGPATTRHTVLMWLLERWSSIADGLFAAGDPQGPERGEDVPLSTYPHYTPSATPNHSVTPPTLRDPAMLSSALIETSTHDARRGSIVSSDGAESVFTSSTAESDDRSLGIGTPFSGEFASLPLSAVREYESEPEWEDAMFRPAEADRSVEQDVCSKHAPAPSPRIGEDMFVELGDSFNLTSDHVRSCSPDGHSPPPESDYETNPVSEEHSRATSRASDVSAGISRCPPDSPLFTAQTLELHERNPPRPSAYDQRRYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8H3</accession>
    <name>A0A4V2K8H3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_848370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8H3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF78">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="14"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="507"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU60048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="548" mass="60907" checksum="A733CE630F89D068" modified="2019-07-31" version="1">MAKMLAGRRLYYTINAVAGLAIFFFGYDQGMMGGVNTSPDYVRVMKLGYSTYEGPSEGYVAHITEPTRQGGIVSIYYFGTLLGCLMGGVLGDRLGRIKTMILGSIWVLFGAALQCSAQNIAWMCCARIINGIGTGHLNAIVPVWSAEVATHTSRGAFIASEFTLNIFGVVVAYWLEFGLGFVGDGTSQVRWRFPIAFQIIPVLGFMACIPWMPESPRWLIKMGRVDEARAILGRLRSEDGNIEAPQAQREYEDIAATVTLEKEHSKRNSYISMFFGFHDGGLHIARRVQLSVWLQIVQEWVGIAAITVYAPTIFAEAGYGARKAQWLSGLNDVTYMLSTLLAVVTIDRLGRRVGLWWGAVGQGISLILAGAFARLLKDHPEKASQYGGAAALFVFLYTFIFGATWLTIPWVYPTETFPLEVRAKGNAFGVFGWSIGNGWLTLLNPVMFNRIGENTLHIFGAINFLSIPLIWAFYPETANRTLEEMDYLFMSKSPFVWDEEANFKRMKEEAERNRIQGKMPLPDSEVEAGEDEKAPPPPVEIENAPEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8J6</accession>
    <name>A0A4V2K8J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_947541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8J6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="321" mass="34679" checksum="5287C2FDE9C8E89A" modified="2019-07-31" version="1">MNKGPMKDGCQILNENQGTLQYSDGWIFTTSDPQGLVHTLHFTNTTGSSVSLMFNASSIVVFGLVPPGPSPPLASYSIDGSLPVAVNLGATTECIPNQQLFSSKPLSGPGPHNLTIFVNQTSSEQPYILDYLWLCGGNSNSTASDDSGNDHKASHGQSSSTDGVIIGSVLGSVVLLLGIAFGVWFYIRRRRRRLQQLRRLHIASSPVTSWLFWNSRSSEKNTLFTSTEDIMADNPTTSSMSTRSRWDTSYRKEVPPLAEMPPPPGVRMSSVSKATSLSRSPSAVPPGIVEDLRGYPRRMSRTSSIAPVSSTLVHGSEDTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8W0</accession>
    <name>A0A4V2K8W0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_197845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8W0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021007950" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="27"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="546" mass="58334" checksum="B14C13707E719497" modified="2019-07-31" version="1">MSTMIVHLVFVSLCLIGTVSTATAGPPVVKLDEATVRGFTEGTSTSFLGIPFAQPPVGKLRLQLPQPIAKYTGVINATTFGNQCIQQTIIPPTIPPNLPPAITPFVDAMATPLSVPQSEDCLNINVIVPAGTQPDAKLPVAAWIYGGGYQIGSNAVRPGAVIVNRSIELGQPVIFVSMNYRLSAFGFLGGSEIQKAGLGNLGLQDQRESLRWVQKHISAFGGDPTKVTIWGESAGSQAVTFQMITNGGNTEGLFRAGWMESGSALPTGDFSKLQPTFDLIVSETGCSSASDVLGCLREVSAEAMSAAMDKTPAFLSFQSLNTPWMPHADGVFLTDGPQKLVLDGSVADIPFVVGSCEDEGTLFSLALLNITTDEAAAAYLKSNYFPNASDATILRLLELYPASPAAGSPFGTGDAFAFTPEFKRLAAFQGDFIFQATRRFLLNQRAGKQVVRSFLNERDKITGLGATHTTELPNVFGGGDMTDFLVRFVNTLDPNGNPEIDWPEYTTESPQLLAFVEGGRNLTIVPDTFRKEGMDFVMQLSLVEPL</sequence>
</entry>
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    <accession>A0A4V2K8W9</accession>
    <name>A0A4V2K8W9_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920418</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8W9"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7994" checksum="BB6772E7A406C5CC" modified="2019-07-31" version="1">MSRLCQTITFSASSVAWGKVEKTNGVRKGSLAPRGSQLKQRVGRRSGAWATTMPDRRPRRRIPERAHPFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9B6</accession>
    <name>A0A4V2K9B6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_917128</name>
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        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
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                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="term" value="P:regulation of signal transduction"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="PPI-2"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
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            <end position="62"/>
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            <end position="242"/>
        </location>
    </feature>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU63268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="251" mass="26585" checksum="64E29FE864B71D63" modified="2019-07-31" version="1">MASEQAAPHHQPSMSRQNSKPKGILKNAPPATPGGTQHSLQWDEENLALTEAQKDSHMKITEPKTPYVRYNAETDTVEGDIPSFDLNGRVASPVSPIRSMSPVSSTGATGGGSGPPSRRTSFSSAGTQGGRSSTPGRGGPGSGSSSRSTSFNLPNEAREVIRLDGRQPGDEIEVEEEMDEEAAAKHAAFVRARGRHYSNEAEAMKMAKKLMAEEDEDVSSVAGSADHTNDSVDEDSVMDEEGSVQVNGVAY</sequence>
</entry>
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    </gene>
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        <lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8831" checksum="4A16D592074AD85A" modified="2019-07-31" version="1">MFARARATKRATRRVGHVAGTFLSLTSRQAPGALGIPATILQAVLRVMLAKSAVLTVLENWPRCSDQAKRSDVPSRTREKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M659</accession>
    <name>A0A4Q9M659_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_182292</name>
        <name evidence="3" type="ORF">BD311DRAFT_679364</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143752">
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    </dbReference>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="26913" checksum="3FD5BF8F7A6F1AA2" modified="2019-07-31" version="1">MTMPRVLIQSPIVPNIHTMIDTTPLPPRQTGLQPAPRATVRTPTDVAPPPVGNLPEAATGVDEEAPPDGLQRMSLVQDFGEQPASQVPTLKEDIISYRLDCLSDEVERLRLLLKNLQNVFEDSTIERVKNLRTDLMTKAGNTERRLGGEIAALKTRIDNEHLDLQQRTHDKFVSMESHVTHRVQKVLDDMHKRFLADVEAQVAAALQTFQEELKVYAAANQERFNQIIQMLLDGRGQATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M805</accession>
    <name>A0A4Q9M805_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_812448</name>
        <name evidence="3" type="ORF">BD311DRAFT_819868</name>
    </gene>
    <organism evidence="3">
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143512">
        <property type="protein sequence ID" value="TBU23200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M805"/>
    <dbReference type="STRING" id="114155.A0A4Q9M805"/>
    <dbReference type="OrthoDB" id="3269067at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="447"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU23200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="474" mass="51859" checksum="590EF671E6C411C6" modified="2019-07-31" version="1">MPGVTRSMPSSASSSYLSVSDALNNLSKAATVALNAVQGAQDHTYQELERTRAERDDALKALHDAQLDSKDMEVRVEGWKAALEKSDLTIKHQTETITQLRSEVQTWKTQLARLEESSRQEIEGWKEQYRRAEHERARLSARIEELIAGQLAWNAAAHAYTAPYTPRIGYAEVPEPPSSSSAATITRHASTSHIHRAAGTPRSNGRAARADADEDEDDRPLTSARKSKGPNGARQPTQPEPRAHPGTGTPARTSTARRRDNAAASAAGIADVPQANASRATPRTPAARSVPGQTGTQPRTQVIRRVTAIVDVKEEESDEAGGLEDLESAASGSAYDPEEDPPMALGRRRRRASNVSGRSKRAVRDFDEDDEDEEGEGTVLEDDGMDGVEQGEDAEDDELLLGSKVRTRVAFSLATARQVLAYFLGHISISRTALTTYVPSHSSQHSKCGKLRERKRERRRAHRNTLELVRARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MB32</accession>
    <name>A0A4Q9MB32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_930403</name>
        <name evidence="2" type="ORF">BD311DRAFT_112162</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143521">
        <property type="protein sequence ID" value="TBU22946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU57001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MB32"/>
    <dbReference type="STRING" id="114155.A0A4Q9MB32"/>
    <dbReference type="OrthoDB" id="2497589at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU22946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="21315" checksum="5DCDCD94A00558FC" modified="2019-07-31" version="1">MAPRKRAAEDDGAGPTTRSAKAPKSDKTDTSPKAARGGRGGKKGLKANLAASAFKARALPIHVNITHTPPVLADRDDGTVTLASTDPGFIGTAALVPSTFATGSYGWKGSKRFTVELENPDGGEEKEKVHVMLTINATVIGSKGAKEGEDGAEADEAAEENGEHAEGETKEAAEAEEQKEAKETNGEAKDEVAKGDDMEEVKDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MHC6</accession>
    <name>A0A4Q9MHC6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_843471</name>
        <name evidence="5" type="ORF">BD311DRAFT_725454</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143440">
        <property type="protein sequence ID" value="TBU26870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MHC6"/>
    <dbReference type="STRING" id="114155.A0A4Q9MHC6"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU26870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU62496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="431" mass="47974" checksum="C14CB04636A49C18" modified="2019-07-31" version="1">MGDLVDMAGFDELEQFAPRLQETFDVDTFETIAESVAAYVTRARFRDASRGSVVAIKSGSVNPRFSMQPHDIGKELRILLNSPHSNVIEVLGHAFEKPMSTVHFWMPFVPYHLLNILASPRFSAFAPPGAVNGASTPDASALLVATKSLVYQTLSALAFVHERKIAHRDVKPQNILITIDGCVKLIDFGVAWSQKPNERDLWPEPPGKMCFDVATGPYRAPELLFGTRDYNAYAIDLWSMGAVLAEFFTPLKLRKACYDEDDWYEDEDEGDWDSDAPPAKLPFVVSKGVSPTSPNAQWVRETLYDSTRGQIGLAWSIFKVHGTPRDETWPTFKQLPDAEKVTFIEVPPADLSKLLPNLPSEGRYQESEDSFDLLTRLLTYEPVMRLPAADALGHPFFKRGLPLVLPQGQGGKTWQGRGLADVISQYISNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MIN2</accession>
    <name>A0A4Q9MIN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NmrA-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_633474</name>
        <name evidence="2" type="ORF">BD311DRAFT_761838</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143441">
        <property type="protein sequence ID" value="TBU26757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MIN2"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05269">
        <property type="entry name" value="TMR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052718">
        <property type="entry name" value="NmrA-type_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129:SF1">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47129">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU26757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="305" mass="33837" checksum="477F73F87819951E" modified="2019-07-31" version="1">MVKYVLTGATGALGSQVFKYLLRLVPASDVIVSLYNPAGATAEITNSGVEIRRGNYSEPTSLDAAFASADKLLLVSYPSIAHAERVAAHKNAIDAAKRVGIKHLYYTSLAFASDSKAEVMQAHLDTEKYLKESGLTYTIIREGIYSESYPLYFGFWSPAEESDEVLVPYSDGGIAWVSREDLGEGTAKIMVEGGYENETRLLSGSQSITLAQIAEKVSQIVGRNLKLVIGTEDEYVRRNRGKHGPRGEEEFLRKWATTFKALERGELDVVDPLLQQILRRPLKPFEESLKEVLDIHRSVVDRYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBW5</accession>
    <name>A0A4Q9NBW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1026348</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU55998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBW5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="504" mass="57188" checksum="6C2D881716A45A07" modified="2019-07-31" version="1">MDRLQATFYGVLAALVWINVFRWRTNRLQHIPTLGGPSDPVLSYLSALNYILNSTKILREGYERFRGSAFKVADLESWTIILNGPEMVDEIRKRPEEELSAVESNEEFLQMRYIFGKEPYEDPYHIYLTRDKLTRTLPAILPDVVDELGETLPEYVPTNGDEWTTIDVTTTTQKIVARLSNRVFVGLPVCRHEVYLKMAVSIATDLIKDAFILKTSPHFLRPIVAWLTSSTRRTVRRALPCLRPVIAARKEQISEHGLGQDWPGKPNDMLQWIIENEMLRGAEDEAIIARILLVNFQAIHTTSTSITHALYHLAACPEYIILLREEVGSIIAAEGWTKTALGKMRKLDSFLKESQRYNGISLVAPGRKALKDVRLSDGTVIPTGTMVNMNTHRLHLDDACYPNANEFDPFRFARIREVDGEGTKHQFVHTSNQYVAFGIGRHACPGRFFASTELKALLAYIVVNYDLKVAGDGKRPRNLYFSHAILPSMSGKIMLRKCLLKETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NF55</accession>
    <name>A0A4Q9NF55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_99988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NF55"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10121" checksum="DD6B5BB7149BD2EE" modified="2019-07-31" version="1">MLLRGRQGLGYVAVVRFLPKIAGCEKCNEGAPQSSSALCARVFAKGLTDYLEGFYKHRMTLAMLGCEEQVIPSGAGGLGETPAGKSCMKHDRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIZ8</accession>
    <name>A0A4Q9NIZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1028113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIZ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="349" mass="39530" checksum="E0D4B4D0AFECF17E" modified="2019-07-31" version="1">MSTGQQKSALNIVMGAMTFGEEGKDGARVHDLNDVKAILDIFQKHGHYEVDTAFVYAGGTSEEYLGKIGWKERGLVVHTKLYPWPVRSAPHRARCGASQRGAISHKPEELRKFLDISLKRLGTDSIDMWYLHGPDRTTPYEDTLRAVNELHKEGKFKRFGISNYTSWEVAELVGIARANGWIQPTVYQGIYNAIHRKVEPELFPCLRKFGIAFYEFNPLGGGFFTGRYRSLEDTSAAADPGSRFDPNTRQGQAYRERYWNERYFGALAKIEAVAQKHGLTLAEIALRWISHHSLLKREHGDAVLIGASSVKHIEQNLVDLEKGPLPEEVLKVLDEAWLEVQPYAANYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLU3</accession>
    <name>A0A4Q9NLU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_938021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="73"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="475" mass="55492" checksum="EE1AEC9B8FA87674" modified="2019-07-31" version="1">MAYLKVSGTKIVDQNGAEVILRGAGLGGWMNMENFISGYPGCEFQIRAALADVVGKEKSELFFDKFLEYFFQDEDAAFFKSLGLNCIRLPFNYRHFEDDMNPRVLKPEGFKHLDRVIDLCSKHGIYTILDLHTAPGGQNTDWHSDAGTHIAKFWEHKDFQDRVVWLWEELAKHYEGNTWIAGYNPLNEPTDPYHTRVVDFYDRVYKAIRSIDPHHALFLDGNTFASDFSHFGDAYKGWENVAYSIHDYSVFGFPSAPEQYVSSETQLRRLRRSYEKKRQWLDERGLCVWNGEWGPVYARKEYEGERTDAINEERYKVLKDQLEIYNKDRLSWSIWLYKDIGFQGMVYVSRETPYMTLFKDFLAKKHRLAIDAWGADDSQVRHIYEPLIDLIKKEVLPEHQNLYPAPVWKLSDRIGRLARNILVSEFLVKEWAEHFRGKSEQEIDEIAKSFAFSNCLHRDGLNRILTDNATLVAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMQ1</accession>
    <name>A0A4Q9NMQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_833109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145271">
        <property type="protein sequence ID" value="TBU52021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMQ1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NMQ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20746" checksum="A391275AA2151E5F" modified="2019-07-31" version="1">MSGMTRASLPKPRPPPLDLTDARETYPRLLEQYVGYTEQAPSLADDRINKRTSLPAYLVESYSRIALHNLDESLGAPIPFESRSISQEIMSNYLHDPPIDEVSSSFTHATANTGSNSPDMSAPITPISLVDATAGLMDSEATSTLHSGFGGFEQGHDWAAAAVQNQWMDGETPRGSKQGLMIELGDVVDLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMT4</accession>
    <name>A0A4Q9NMT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_386145</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMT4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10078" checksum="466C9D3A6F1CACFC" modified="2019-07-31" version="1">MPASALSLQCSFMLVPSTTPSVFIDISTNRLLYFSCTHLTSSASHRLSCASPLSIPGVDRSCPVLIETICGEGSECRRARQKASPSHIPRSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPL2</accession>
    <name>A0A4Q9NPL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_882039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPL2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="194"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="485"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="905" mass="101957" checksum="0B5A7195FE4FBDC9" modified="2019-07-31" version="1">MGPRFYLVESDVFSARIPGDAPTEVERSDFESPKLTKGMSEKSIHLQLRKVVRSVLKAAGCKNLRVLDTANHNAKEGNCNKKVFNDAGIYLNTPLTRRAITRAPEHDKESTTKEQLKTHRLGPPSWHWMEVPMVVKANKVDSAFYFKRRPHVEEVEKSTEQDGVESEQTTDALGPESVKKRAEPLLRLSDYRGRESYGHLVNYMDHVFNYQHRTFCYAVYVCFDMARLLYFDRSGAYVTEALSWVETTSLLHELVWKTARLAVTKKFGDMGHDSTATMVDNQTRKRFIKEARNLDLPSHVRAGLAQATESYCPLYMLEVEYVPPSPDEWFPDEPFPFAPEEPTDDAHLDEPLSEPSATLSSSSPMSAKEATPSSDKTVPRVRKFIVGRPHFAGEALVGRCTKGYMAFDVTDPMHWAPCFVKDTWRPYIPNRTRPEHLVYERLLRKGIKPSDGIATFICGGDVGGSRAQWTRIPSDLPGDHGSVPHIHYRVATADIGLPVSQFKTFGELSGLFADALKAHGKVWDLAGVLHRDISVNNIMIRVGQDGQKYGFLIDWELSKVQCELGQGPVKPDRAGTWDFFSTLYLRYPKKPYRRSDDIESFIYAYLYLVLHYHRISAVGLQQQDRSIFKSKAFINGAMVGGDAKWSMMRSGQLPFEIPDNPYLQELLVKILCGCNSCYESINADEMERVYGVFERVTRIKPLKQRVPENAPEDPRRVRRSRFRRLREEGSSGENPYLAIFAKPRPDPPPKSPMEMLEMGSFLSSPDPLRMLLIEHAEKASDLQDKAPDQFHARKHEDCYRPYDLPPDTSGTSTMDDTSGAASSGRSWSEDDSTASSSTGKSKPKAQAPLPSGSSRPKKRALDEDPQDDVTAHDDGEGPLPVRRSKRIKASNGKVPQGPSGEDKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRM1</accession>
    <name>A0A4Q9NRM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_957656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRM1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="216" mass="24302" checksum="387BC331D7AF00A8" modified="2019-07-31" version="1">MSNANPFDLADLLETGLVIQDNPRGRGKIGTLFLCPFPGCEKEFSVKWNLKVHFKFVHLRAGTRYACSVLGCGGVCTLHSDLPKHVQHEHPSVGHPAEENVQPAAFMDTDAFERNNVRALHLVNPPMDLLVQDAPQSPRQAADAKPFVCHHADCNAAFAHTRNLRLHCTLVHSEARRDFACSAPGCSRMYKRNHDLRRHMRRSHERARERLSDSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NX15</accession>
    <name>A0A4Q9NX15_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_936306</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DPH3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NX15"/>
    <dbReference type="STRING" id="114155.A0A4Q9NX15"/>
    <dbReference type="OMA" id="IADEQPR"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="10">
        <location>
            <begin position="4"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="62"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU54232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13485" checksum="C86702CB426132EE" modified="2019-07-31" version="1">MGAYYDEVEIEDMVWDEEKRVYHYPCPCGDRFEISRKQLKNYEDVATCPSCSLVIRVIYDPLDFEDDPSDDEDEGASAEEEEDDEDEDEDSEEETFEDAMEHLTIADEKPQAIAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZD3</accession>
    <name>A0A4Q9NZD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZD3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8041" checksum="E86754BCD4B74581" modified="2019-07-31" version="1">MLSPSGRARLPAGPRPSRGWFAVSERGGRRTHGAPLLLGSQLLFPAPVGMQSLDGMRQQPSGFIFGLTSDTCAASSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1C6</accession>
    <name>A0A4Q9P1C6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_914731</name>
        <name evidence="5" type="ORF">BD311DRAFT_97574</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1C6"/>
    <dbReference type="OMA" id="WLHNFDP"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="383" mass="43005" checksum="CA1CD44F7E3B3C45" modified="2019-07-31" version="1">MAPFWVPAAAPPTNLGRYRQLAPLAGVHVSPLQLGAMSIGDKWGPLGFGAMDKASSFKLLDAFYEKGGNFIDTANTYQDESSEEFIGEWMEKRGIRDQMVIATKYSTNWKRAATDIAQKVHYAGNNLKSMHISLEASLKKLRTNYIDIFYVHWWDWDTSVEEVMNGLHNLVVSGKVLYLGISDTPAWIVSKANTYARMAGKTPFVIYQGAWSILQRDFERDIIPMARAEGLALAPWNVLAGGRIRTDEEEERRRQTGENGRTANRPDWQRTPDERKMCKALEEVAKQVGAKSIQAVAIAYVMQKTPYVFPIVGGRKVEQLEDNIEGLNIALSEEQIKYLEGVLSFDAGFPHNFVGDGSHYILLQSSAATLEKWPRQQAIRPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2U1</accession>
    <name>A0A4Q9P2U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_976419</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2U1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P2U1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="287" mass="30836" checksum="C3E9C2081A435AAB" modified="2019-07-31" version="1">MASIFQLVCCCCARGGPSGQNEPDEHTPLFQPSDDSPPARNYTVDHQKMKERLGHIVRSKEGKMVNVNQPLPFNLHNRPTYGRPDRSVSTNTTPPRPTSSTSQNNPSPDSPSVSTFQKQPTVPPYVPSRDPSPSIQTSRSTSSLHPGDASYLPPEADPDGGFRRAILNVRLVRGPGGFTPGGRARQGRSVTRGRLGRFGEHSGESAEDVNGKGKQVENSRDGIEVESPSPAEEGSQNRNLGQPHQLGNGGQAAGRGSPDAVPDRRAPFLATEFKIEDVGSLSQSWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P322</accession>
    <name>A0A4Q9P322_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1033681</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
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    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="188"/>
            <end position="223"/>
        </location>
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            <end position="392"/>
        </location>
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            <begin position="408"/>
            <end position="427"/>
        </location>
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        <location>
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            <begin position="85"/>
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        </location>
    </feature>
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        <location>
            <begin position="351"/>
            <end position="366"/>
        </location>
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        <location>
            <begin position="417"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
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            <end position="502"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="565" mass="58536" checksum="3D5509413C3D19D4" modified="2019-07-31" version="1">MAPVQCVACKEIWSSKSKSGKHSLTPGHRLVFVCVPCAKTFTAVADLLQHQTAMGHRDPEELGGGKGKSASPAPPGLSRPVSMHASHASTVSGSGSASPSGVVVGEGGTMDGPACPVCQMGFGAYDQLAEHVSRMLPCAGCMTCLDPFQTLEDHYWDSPSHPKCKPCALGFENLGKWTEHKISCPVAPLGSRPAPNNSNGRAAGKRPTLPSPQPVTGPAPNTFGSTSLAGIAVSVASSTSSSEDGFRSTYSPGHLPNAYSNGAGPSRFAPTPTGGVPARAEAAVAETNGTTSFSCSKCKTQYASQELLQQHFNQSTMHHTCKTCGMGFETAASWATHRGRCPPPGSYKADAPSGPATTDGPAAPDPARTPQADHAALPPQPTEQRSEVGAPEANPSAAMMLASTMMLPSEDGRSPAASVSTSRASTPISVLRSTASSGPSVGGPASFYTPALSSRSVSNYGMSVGQSSAASTRSPTPAPPREYSTRPLFQHAQPNGGQQQLASPKKRVSLHCRSCRMDPCVDPTTTACGHLFCHSCIMAELARHGGCPVCQRSFLTKMHIEVEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P393</accession>
    <name>A0A4Q9P393_9APHY</name>
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        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        <dbReference type="NCBI Taxonomy" id="114155"/>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <end position="60"/>
        </location>
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            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="101" mass="10458" checksum="045BF9C7B0390A4F" modified="2019-07-31" version="1">MSAPQPQNDSFGTSSPPLEATKGGEEPMGVSSISGDKPKGVPDKQQRGGAHSSIILQSPRVLTQPAVRLDYFKDNWKDSDAGGGDGAEQVSAVMGCADAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5Z0</accession>
    <name>A0A4Q9P5Z0_9APHY</name>
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        </submittedName>
    </protein>
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    </gene>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
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        </subcellularLocation>
    </comment>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU57659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="572" mass="63009" checksum="1741D99C50BF4625" modified="2019-07-31" version="1">MTANTYYSYQHNLKTSFPTHSSNMTAPLERGKACSRCRLRCDGQRPACGQCVRSERAEDCEYLDGPGPTQNQLLEGEIARLEGQIARLSAGSAPVTLHDPYAAWYQAQRNAQTQQNANDPTRTLIQHFVRHATEFGFFLDISRFLDKVFTHSPSRSQSMGILLKVIYLIGAKLSNVPQMLAQEQAYLTRALQVLPTALPEDPRSAIYVMQAEVLLANYFFNNNRQLEGVYHTNAAVSIAMASKLHIIRSAGRSRSGDSSTYRLPPPADALEEGERINGFWTVFVMDRCWAVASGSTPAFTDDEASGTQIDTPWPMELSRYQSHPLPSDLRTRNTVRSFIAGSDSDANMTGQSLLAIHAKAAILYESAARLASRYNPYELASQASFLSLDNRIERFKQALPRIEQFDPSRADFVRQALLTHTLAHCATIQLHTPLVQQGVTANSRTCQAAHAAVRNLNSRHVSSAPILYCVNPFNGILWPSVARVLSQGISTARRQRAAGASGSSQGMPDEGTLQSDFQRVVAVMNQNAAFSPLMSMSWTLLLCDDRMIHCSCPSVLCSTGTQVGTLLPARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7L2</accession>
    <name>A0A4Q9P7L2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptide-methionine (R)-S-oxide reductase</fullName>
            <ecNumber evidence="5">1.8.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_814091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.12" evidence="5"/>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7L2"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7L2"/>
    <dbReference type="OMA" id="DEQWRAE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.150.20:FF:000009">
        <property type="entry name" value="Peptide-methionine (R)-S-oxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.20">
        <property type="entry name" value="Peptide methionine sulfoxide reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00357">
        <property type="entry name" value="peptide-methionine (R)-S-oxide reductase MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46081:SF8">
        <property type="entry name" value="PEPTIDE METHIONINE SULFOXIDE REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU60947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="136" mass="15035" checksum="5C5C4CED9F35AF5F" modified="2019-07-31" version="1">MSDPTKQKSDSEWRAILSPEQFRILRQKGTEPAGTGKYDKFSEEGVYTCAGCGTPLYKSTTKFNSGCGWPAFFDAIPGAVNRHEDRSYGMTRTEITCAACGGHLGHVFKGEGFPTPTDERHCVNSISLNFSEERKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8V3</accession>
    <name>A0A4Q9P8V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_779632</name>
        <name evidence="2" type="ORF">BD310DRAFT_780502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145541">
        <property type="protein sequence ID" value="TBU50954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145486">
        <property type="protein sequence ID" value="TBU50984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8V3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU50984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="143" mass="16608" checksum="0F32123698C21958" modified="2019-07-31" version="1" fragment="single">AYTHLVLRRSLSSRSPTPPSNKKARKHDTHKPRRHASRDRHQQDDPHRHRREGDRARERGRSRDRDPQLGSAERGQHPDMRRPVLGKTSRPPQNWVDDWLAQEEAELAEDPEANQPPVVDFTQPRPQPSANASRPPRLVPRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P914</accession>
    <name>A0A4Q9P914_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_910879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145398">
        <property type="protein sequence ID" value="TBU51100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P914"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="289" mass="32550" checksum="734FCCDA2CFEA877" modified="2019-07-31" version="1">MSDTSPPFVLQQTVEGGLKFLMLGTVLSSFLIPIAIMLFYFSTARLRRQPLFILNFLAILLGIAQGVLNFYSATSGMLHNANISTLDSALCVALDVFVPLCAETVLILRVLAVYPPRLLPRFQCFILYGSIVLLKVGRVVNVTYVIYRMVRGPSEQAALVLAEFVWHLPNAKLEYILQLVDDTLVSGLFLYKIHTKTHEVASDRHHESGIRRARDMYLFRRLKTLFWISVCNFVFPVVLNVVQLVLILGNGEFERGILVQLVNNYITIIGVLLATIWASSSQWQEEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P984</accession>
    <name>A0A4Q9P984_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_915201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P984"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21330" checksum="B282D67DDEEF9E29" modified="2019-07-31" version="1">MFTATMLLRVAVAAFVASLAFVTAMPSFEGYTSWDSIGNLVPGMSYLEGLGPATTQGAANHVPFYLSIAATRGNPGNVTMYRNRSPPLFYIHQSQLWHYHNESTILPVNVHNSTGTGQLPLQMIAGTKPDGVPGGRWRWQGTMLFYENGAQDNQGLFYACADVNGLNGMFLFLQCSPPPPGCTPFTVHSFSSNRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9Y0</accession>
    <name>A0A4Q9P9Y0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_910787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145356">
        <property type="protein sequence ID" value="TBU51238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9Y0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="14805" checksum="96CE73E499B5E7E1" modified="2019-07-31" version="1">MTTSSVHPQSFGSDQESSDASSTQVEGIAITHQLEDGQTVKLSHGSCWAKPTAIVTFCPKESLVGVFGLAGPPTSCEKRAMINSINFIILDSKTMTIRTEGALILAYSLSGIVTKATRVRYSVSDVFASGGFAESNTIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBT0</accession>
    <name>A0A4Q9PBT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">O-acetylhomoserine ami</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_999197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145261">
        <property type="protein sequence ID" value="TBU52210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBT0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBT0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="428" mass="45913" checksum="E7498C724BD33AB1" modified="2019-07-31" version="1" fragment="single">REPEFETLQLHAGQEPDPTTNARAPPIYASTSFVFNNSQHGADLFGLRALGNIYSRIGNPTVDVFEKRIAALEGGAAAVAASSGQSAQFMAITAIAKAGDNIVSTSYLYGGTYNQFKVYLKRFQIGIKFVESSDPAAYAAAIDENTKAIYVESIGNPKYNVAPLPELAKVAHDHGIPLIVDNTFGMGGYLVRPIEHGADIVVHSATKWIGGHGTTIAGVVVDSGKFDWAKSGRFPDFTEPSEGYHGLKFSETFGPVAFAVKVRVEVLRDLGSALNPFGAFLLLQGLETLSLRAQRHSDNALLLAQWLEEHPKIAWVSYLGLPSHAFHKEALRLFRPNAFGGTLSFGIKGNDAKVGSEVVDRLKLASNLANVGDAKTLVIHPATTTHQQLSDAEQLASGVTPDLIRVSVGIENIADIIADFEHALKAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDN2</accession>
    <name>A0A4Q9PDN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_939050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDN2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDN2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU52929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="261" mass="29041" checksum="B8A9C856E56E031A" modified="2019-07-31" version="1">MGAGSDTRFWRIATGPHKDTVVKYIEVDFTENTTKKAMAIRKSKELSAVLGTPEDVSLANGGAALHSPVYHLLAADLRTPPAQSLVPLLTAEPQPLLSPSVPTLLLFECVLAYMSPNTGNALLQWFTDYFSAPGAVLGCIVYEMFALEDSFGKVMVNNLRARNITLPGAQPYPTFASLANRFLQHDWEISRAVTLKDIRREYIEPSELQRISQLEMLDEIEELELVLAHYAITWGAKLPPNAVALKAQWSEWSLRRKVSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE28</accession>
    <name>A0A4Q9PE28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11837" checksum="DA393ED56C76058F" modified="2019-07-31" version="1">MGFEGLWATRTLAPSKRPDKSQLASAEQAMDGCREDTRKHVSSTLWVIDERNLNVTTITVWGPMGYGVEFPLSRLGKAKILWVFRVYGLPGVWVRRVSTVQMILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFA3</accession>
    <name>A0A4Q9PFA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_202305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFA3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21550" checksum="D99D04BD1C805532" modified="2019-07-31" version="1">MTYLVRGTSEDCAELLRGREVTRISLRASDQFVYARFATELEEEIRLSKKSPLTTASKLNLSMDRGGIYKADISFPLKPHVRHLEAVTATTCAHTRVSSGFNPESVEDIAAGDDRYKAKYAHWFPKPAELPEVEDTPDSLKTPYPLETPKTMLRLRSQWMKDHSEVWQTAVTSPGRTRSDVVGLVTKSFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFP5</accession>
    <name>A0A4Q9PFP5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_937381</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFP5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFP5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000006">
        <property type="entry name" value="Puromycin-sensitive aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="19"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="263"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="559"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU53789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="900" mass="101807" checksum="3DA0717A4083473A" modified="2019-07-31" version="1">MSEEFAPQKDYRLSKNIAPEHYDLTIWTDLQDLKFSGTVEISLRIGTDTSTVVLNSLALEFSEVSLHSYALQNTQTPSATEIDDTRQRVIFTFPDVLPANSTARLKIAFKADVSSQMMGYYRSTGGKDSKTVYALTQFQPTAARRAFPCWDEPNFKATFAITMISRKDTVNISNMPVAHEEVYTPQLEVEEGSWIANTFASLLHPSDWKITTFETTPPMSSYIIAYANGPFEYIESSYKSTLSGKVRPLRFYGTANAIPHAQFALDTVTKIMPIYEQMFDIEYPLPKLDIFAVDDFDLGGMENWGLVICRTQYLLHDPTSNDVQNQQSVASMVGHEVAHMWFGDITTMEWWDNLYLNEGFATLMGDKAILGKRVWPEWKPDSEFLGSSFFQARQLDAKLSSHPVEVECPNEDSILQIFDALSYAKAASVLRMLSSHVGEHQFLKGVSIYLKKHLYKNAVTKDLWEGIQAATNLDIPKIMDTWIKEMGYPVLTVTETEDGLHIRQDRFLETGPAEEKHNQIIWTVPLSILTVSDDGKPTVQKHIFDTRENFYSLETSKVFKLNVDTTGFYAVQYSPERLVRLGRTAALPDSPFSLSDRIGLVWDASALAKAGYAPVSSAFALIRMLQGEKEYFVWDTIATNIEEIVSTWYEKPQVVELLNAFRRDLFVPVVKRLGLKYSISDSPNDRLLRTLAVRQAAAAGNPEVVAELKAWYAHLLQTGNDSKIPSELQGVTFKVGVGEGGRPEWEYAKQLASNPKNPAQGVAALYAVGASKDLGLAEETFQFALTGVRDQDIPRCLSGLQQNPLTRKFLAERVKDRFDELEKRYAGTFNFKRFIEVSFRYLSSDKDYEATAAFLKDRDTAAYDQALRQSLDNIKTRAAWVKRSTEELTEWLKRRPEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFR4</accession>
    <name>A0A4Q9PFR4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_980806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFR4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26382" checksum="04FE1986DBEAD5A5" modified="2019-07-31" version="1">MFVAEDTEFRVYKVPLSKHSAVFKDMFSLPQPAAASADEPPVLEQLVRQVADYLTSQYPTTYEAYAAITVEDHIPGSDPSIHHIAVVNLATLSDTPSLLPSALFACCSIPPNRLVQEQLSLDDLTRVLVGRAELTKLDAEAAVAIFRPWPSPCCREIQSKNCLELLQTALVKPFGSRNGPKSFGPSWELSWVTDYVIDMNMLFCPACEKLIARREDDKRRDIWKRLPSIFGLEVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG41</accession>
    <name>A0A4Q9PG41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_971296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145337">
        <property type="protein sequence ID" value="TBU51346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG41"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21302" checksum="4B57E6B00385532F" modified="2019-07-31" version="1">MTADSGRHSGRPDAQKDGPHTGPALAPGDVRGKLPTTKRARWVKHSIRLDSAVRTLELLSAATGRKERKMDWVPSTTPCVPRRDHADSEIWTAGIATSCPSDLRSFSSELESGDPIHRVASLRNSLHPIQLAAGASRLNGVVPDMAFPTTAAQMPRPVPCAYNGANAVASSSKAQTSIAAAGDVPRPEKAKMIGVQPCTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGI9</accession>
    <name>A0A4Q9PGI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_998033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145251">
        <property type="protein sequence ID" value="TBU52437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGI9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGI9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020530848" evidence="1">
        <location>
            <begin position="23"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="309" mass="34578" checksum="7C817ECE462F3687" modified="2019-07-31" version="1">MLGTRTFWRHLLPSCARCGVAALCCQAAAQHPFHPKFEQAIVVYMEAIAKDSWEMRSRRSIGESDENFFNLMPRLFLYKDSALMKSAKDARSSTSAAKPPMALVTHKNVLQPRAMLMMPRTLLDLSRRRPKMASARTARVALGGDVTYIRQRSVCLSNECASDQEQEPTRRLEPAVSNQGVWETLFQKIVVAFPDERFSTGQISHELRLIEENHAYNAPSVSVLLRPSIWIVAHYLLQHPAEIRMVDKDYSPALGPKARPPMTISTYTHRTANGKTDAVELATFMTSSEGKIVGVELQDATVNGCIMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI44</accession>
    <name>A0A4Q9PI44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_202316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="7144" checksum="B1566D77BD253DAC" modified="2019-07-31" version="1">MRGNHLRKLERGEAQDDRSLGDALRGEVIEVLICPGTRTNRQSRQDLCLRDQTQDNFLDFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIA8</accession>
    <name>A0A4Q9PIA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="1">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="1"/>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIA8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF1">
        <property type="entry name" value="QUEUOSINE SALVAGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="415" mass="45349" checksum="B275B0FAA55F6FE1" modified="2019-07-31" version="1">MSSELVPFPPSGEYLKAVRESSRAARLKANITISDESIKRFLLSPAFTSTYTRLRAAHGMTLPLNFSSIKEELNILSVLSLLNFGSGYRVPLHIATGRGAFDNIRAFVFGAYISAASAGDHFSAHGMKEITPATVANLMRVMDAIHVERPHEEIPGVTVGELSGPIWEIVQIIAKTLNETGEALVNGGYPDLGSLVFEALGEGEKARKAGRDECEVIVERLVRGIPAFRDMALVQGQPVYCFKKAMLTVHAIALRYKASDTPPVPVPRTDHLPIFSDNVIPSLLVHLGVIDLSTADASLGLQQLFPEAQNPQLLEALLSAAQPVEPVVAKIISPPKEGPLLTVEQAFVLRAAAIDACELIVQYAKTLDISGAAEDWSWMKDITLPELDAWIWAVAKDRPDYRKLERFALRNTAYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIS1</accession>
    <name>A0A4Q9PIS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">Eukaryotic translation initiation factor 2A</fullName>
            <shortName evidence="8">eIF-2A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_112761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145201">
        <property type="protein sequence ID" value="TBU53956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIS1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIS1"/>
    <dbReference type="OMA" id="RCCAYSP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017222">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="468"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="570"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU53956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="645" mass="69744" checksum="6224D8D8CF3CA384" modified="2019-07-31" version="1">MASQPSQQYAYRAQKSFGLVGGTPNYDSIDSFQAPEVPARTYQYSPDGRLLAYAIPTGVRIFQAESAQLLQELSLPNVLEIGFSPRGTYLSTWERPQKFEDGTQHKNLRIFSVSTGEELVAFSQKSQEGWELQYTISESHAVRLVGQEIQVFRPAEWSKGVVDKLKVEGATSITLSPGLNPSVAVFVAEKKGQPATVKIYSLTALNGLPTCQKTFFKAQRSQIKWNTLGTQVLVLTATDVDQANKSYYGETGGLYLLSAAGNFDCRVTLDKDGPVHDLAWSPNSKEFVVSYGFMPAKTMLFDQRARTLHDFGTAFCNFISFNPQGRLLAIAGFGNLAGKVDIYDRRTLNKVTSIDASNTSHCEWSPDGRFLLTATLSPRLRVDNGIKIWHCTGPLVHVQLTEELYQVSWRPTPVDALPPFPQNIPPAPAPAPSVLQHADVAKPTPTKPAGAYRPPGLRGLEASAAYKREDGTPSGQSTPNGRYSRSPAPGRFQNGRKHVPGAPTSPSPVRQAGGDQEKRGRKRKGAKDKEKKEGGKKEGGEVDGGARPSLDINVNGNGNVVVADAGAGAGADGADGAVSIPPTPGADGGLDPIAKKVRNLTKKLKAIDELKDKQKKGERLEATQLKKIETEAEIRKELAGLGINP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIU3</accession>
    <name>A0A4Q9PIU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Di-sulfide bridge nucleocytoplasmic transport domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_936901</name>
        <name evidence="4" type="ORF">BD311DRAFT_776562</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143403">
        <property type="protein sequence ID" value="TBU30839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIU3"/>
    <dbReference type="OMA" id="HPHIPRI"/>
    <dbReference type="OrthoDB" id="5961at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="3">
        <location>
            <begin position="195"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU30839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="390" mass="43869" checksum="FA971BAFF3F7C571" modified="2019-07-31" version="1">MQRRTDRSTEAPMDYEYTHRKETTPVWMSPSKRLYNEINPPTPTLSAPGTPSRPTFGHNTNTPFLFNIPAPQTPHPPAWVPPPNFSPEKAFPQPELHDVEMSESSPGSKLTEQEQDGEGNRPVSGAALRRVYKRRNQRDRSRLGRRHARVDDGESSGEESGEEGDHAPLTQKTTNHYTLNMAGPIAPQSDLPFRLLGYVQFVFNAALALLGIYLLVLFVLTVSRDVEYRVAEYSMDIVQDIAQCNLAYKANLCEKGTVPAMAAQCAAWETCMNRDPTKVGRAKVSMEVIGETVNSFVEPISWKTLAFVISSLAFFTLFINSLPSFFRPREIAAPPPRHIPSYPIPPAIPYHPSHGYLPPPEWSNKPWKRDEVEVAPRRRRLEDGQVAKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJT9</accession>
    <name>A0A4Q9PJT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_828167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17558" checksum="05E793592956CFC6" modified="2019-07-31" version="1" fragment="single">KVEVVTRSSLIASDLVVLCVTWYQTHDSAALSIRSLGRRSFASILFLNGTIYFLALLILSVLQMSFTLNRVAESGGNLVTSVVIVLEEPLTSILTSRFLIDLQRAQRNLVDSSRSVSLREVALQPQISENTDRRYFIGSLGAQLSFHEIGERENEAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJU1</accession>
    <name>A0A4Q9PJU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_78631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJU1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="20040" checksum="ED2441D0622B8418" modified="2019-07-31" version="1">MIPHSFYVAYDMLRSNLESFSVKGPIVHVFGCMVAIDDLGCWPAFVYLMCGELMVILLTLLKRYVDPVTFADTRSYSSILLYTIYRDGTWFWAIVLVFSITNLLVMFLAPRELNFSMQQFLRTAHSALCTRVLLNLKKAAAAAEDSRAGEFTVETTLALETLPMFAPHGGEDFDGDNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKM8</accession>
    <name>A0A4Q9PKM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_951231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="250" mass="26991" checksum="81566E7DEB7A5517" modified="2019-07-31" version="1">MPDDPSPAEPPATTKPTEDIAHNLLQCELSQWTCGTKPAVVHGSDSSKDLRRMSCAVLPGEMPRCVQPILILFCIDWCHTKFFVENLDTCARVDPPRPPAFKGSIPSVRPLPTALMGCCIFRSAELVNGFAHEDGKPEKLSPEDIGRCSLGRANLMQANTLATLRRLCPDALRGLHGARRPCAGVPEAPDELRDHERVLREIWKKVSKSTGVVVEGWAADPAPAGDILPAVDGGAQVTNGMFVPTITGPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMK7</accession>
    <name>A0A4Q9PMK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_825827</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMK7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMK7"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
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        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="13">
        <location>
            <begin position="35"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="11">
        <location>
            <begin position="176"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="12">
        <location>
            <begin position="453"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU55479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="565" mass="61129" checksum="D69E54F196321BC5" modified="2019-07-31" version="1">MAAQLPIPVFTSLDQAFPDLQTAAIQGVRYKEVVEEYEKRFGHKPTYIARAPGRVNLIGEHIDYVLFGAFPAAIERDILIACGPSLPSSTSGAAETLTVGGVRAENLNPKYAPQTFAPMLKTAGPSAQEEADAASTVHAESAWHLDINTRELRWESYIKAGYYGVLSRFFPAALAETDKQAHPVPVDLLFTGSVPSGSGLSSSAAMVVASTLAFLTVNNKLDGVTKGSLVEMAMENEKRVGVNSGGLDQAASVICTPHSALYVTFYPKLDAELIPLPTPRTSPRAVFVCANSLVVSDKVVSAKWHYNLRVVETLVGARVLANKLGITLGPNERPTFRVILSRWLGAPESGLDADGLKVGIERFLPEVEKLRPPREGRPAGEEGVTLDELVELSGLSKEQFHKVYLSWVEVEAEYFQLYKRARHVFTEALRVIEFREVCLRANAASGELPADTLVKLGELMDQSHESCSTLCESSCPEVDALCRLAKSAGAFGSRITGAGWGGCTVSLVAEDKVGEFIQKVKEGYEPYRALEGEKLREAIFATKPSAGAFGELFVALLLDMCSCWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMW9</accession>
    <name>A0A4Q9PMW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_856312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMW9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11264" checksum="FEC2058ABD92619F" modified="2019-07-31" version="1" fragment="single">MVLPACEYHGSAGMYKISQSADVICVIWCSLQAASQGFSQAPTNISANKLGPSSRARIAPKEMLLAVCEASALGQHHGPSSLPEYRSRRSFRIAATRSQVDMYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP46</accession>
    <name>A0A4Q9PP46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_648788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP46"/>
    <dbReference type="STRING" id="114155.A0A4Q9PP46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="162"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26005" checksum="8B0E41B547ACDF2A" modified="2019-07-31" version="1">MRSRDMEAPGSMVEARTTLPQIYVDDSDPGIQYHGSWIHSPISDPENFNYAGSVTFSNTSGDTATYTFTGTQIGVFGAFEIAGTFDMHSSYSIDGESVANFIPASTVVKPAYRQKFFAPPTLADGEHTLVITNLGQEMWFDYVLVTLTSSTMSSTISVASELSQAPPSTSSTTQAASPPNMQATTSFAGSPPPDTHLSTMYRSLPGASSSQPSTTSSISNIASTLTSSLTTASLWSRLHPPDSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPN4</accession>
    <name>A0A4Q9PPN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_633026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPN4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16313" checksum="E29B0A5D6995C407" modified="2019-07-31" version="1">MSGAAAASMDSKASDKKATKFFLPRPAVDLREALYANGRQPSDSEKWTAYELIVKMEGCESYARKTHSNYCTHIERKRKAGMKDHVAAWLQQVPNPSLADMLLWSRVLQVSPSIVFEIITKQVPRGVTEFVELQHALSLCNMTPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRB9</accession>
    <name>A0A4Q9PRB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate dehydrogenase assembly factor 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_930617</name>
        <name evidence="4" type="ORF">BD311DRAFT_748207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDHAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRB9"/>
    <dbReference type="OrthoDB" id="201362at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012875">
        <property type="entry name" value="SDHF4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28524:SF3">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07896">
        <property type="entry name" value="DUF1674"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="61"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="103"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU33906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU56834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13700" checksum="6D7253431832775A" modified="2019-07-31" version="1">MYRTAIASALRARRSRTAHAVGNACTARAMSSGGSLVRPAPPPLPREQQQEFEELVRAAQAPLSAKGSAAQEEADMALHPDARAPLQAEFEGDMNPVTGEQGGPKREPVGRWAEDGGDWSFKGRVSDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRP4</accession>
    <name>A0A4Q9PRP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_572983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12911" checksum="BA5E4B2DE056526F" modified="2019-07-31" version="1">MTQFYPAFHGEIHTSSLPLGQRFAMRVILKELPRSRRADMAFRCLNDARTIPLSGRVVKPNGIWVWEASFTNWAVFFQNERVCKEVDVLVDVVSRLRSGYQVIDLLDIAQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS38</accession>
    <name>A0A4Q9PS38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Auxin efflux carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_822122</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS38"/>
    <dbReference type="STRING" id="114155.A0A4Q9PS38"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040254">
        <property type="entry name" value="Ecm3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274:SF1">
        <property type="entry name" value="AGL149CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31274">
        <property type="entry name" value="PROTEIN ECM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="564" mass="60077" checksum="652689B7FD358C05" modified="2019-07-31" version="1">MTLSAAFLVYSGVMPLIKTFAALICGYVLVKLDMFPPAASRGVSIISMNIALPALIFANIVPSFTPSNASALGPLLMMGFVYQGMGFVMGVLIRELCYVPQNFWQGIIVLTGMSNWGNLPSAIVMSVTQQPPFNPALDPALGVSYVSIFSVTYHTVFWVCGAANSLAWDYLPGVPQGEDAERRVSWKEKPIGRLVARALRLPIVPTPPFVPQSNKKDEEAFPAKEDKSSPSPSSTDSSSVDTPVTNVPTIMITEEPKADSEMQLVSRLSPLSAGSTIRSRRLTIVIPPTPVRVSAAPSPLRPSVPSTPGWATAPSSPTRVAALTPSMISVIPATPTRSIPPTTPIRSVHSIHSLEDPVVISALAQSAAGPQKKRSRLRDSFFALLKPVTISLAISLPTALVLPLKALFVSCASQGCPNWHGPDNRPPLAFVMDTAQFVDTIAVPLALILLGASFARIKVPRPLSRLPIMAMLLVTLAKMVLLPVIGVVVVQAMVRGGFIPADAKAERFVAMLLSGTPSAVNQMIVSSLYAPDGNVDTLAAFLLVQCEFCKVQNALLTEIILSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTY1</accession>
    <name>A0A4Q9PTY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Catalase</fullName>
            <ecNumber evidence="11">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_959250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 12">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the catalase family.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="11"/>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTY1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTY1"/>
    <dbReference type="OMA" id="QERMVWH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="6 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="4 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020995015" description="Catalase" evidence="13">
        <location>
            <begin position="22"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Catalase core" evidence="14">
        <location>
            <begin position="69"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU57889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="570" mass="63957" checksum="4767DF9E8BD6F833" modified="2019-07-31" version="1">MLSPAFRIILATVSVTTAVNGWYPGQDAPGLARDTAPPSQAESFNFDVNTGFNVQEKTSGEDATEVDYTLDNGSPYPHPYQYVRIGSDGPLLLQDTHLLELFGSFDRERIPERVVHARGAGAHGYFEATNAEFAKNYTMMDLLSEDGLRTPITIRFSTVGGESGSADEARDPRGFAIKFRTRKGILDLVMNNTPVFFIRDPAKFPHFIHTQKRHPASHLRDKDMFWDYLGSNPESLYQVMRLFSDLGTPYGFRHMHAWTGHTYRWVKQDGSWVYVKLYAESMQGVRNFTNADATAIAGLNPDFATQDLYESIQNGTYPGWTMYAQVLTPQEAETFKYNVLDLTKDWGFDDVPKTEIGKFYLTQNPDNYFAEIEQAAFTPSHAVDGWAPSADPVLQARLFSYPDTHRYRLGVNHMQIPVNAPINPVANFERDGAMNVNGNQGSRPNYLSTLQKINLPPRPYVDETHQQWTGGAVASLSAVTEIDFDWPRRFWNSLSAQDQQNLIDNVVGHLGAAPTESVRQRMASLFYHANETLGKAIADGVGVTVTPLTFPDGPTWFNVTKDTRNSTLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU11</accession>
    <name>A0A4Q9PU11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_820338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU11"/>
    <dbReference type="STRING" id="114155.A0A4Q9PU11"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="236" mass="26327" checksum="9F701E64E309DBE1" modified="2019-07-31" version="1">MRFPRDGPELKSWVRLSLTARALNTANVVLVCHGLYYWAWSLVVGTAMTGINVQHQVLAKRSVAISPGQLLMLIAKNNDQLVLCKSDSLCTLFFMKRIYKLCQTRLTRYTLPITMALLVLAHLVLGAQTMVKVISTFESSSLDSLEALAFSTTLPYMVLAVASDGFLAGTLTLMSRGRNPEWDKSIMTLFIHQAITLLINRCVLIAVAAIARLVMFTILPWTAWFIVADFIMGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUM0</accession>
    <name>A0A4Q9PUM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_820281</name>
        <name evidence="3" type="ORF">BD311DRAFT_812424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143628">
        <property type="protein sequence ID" value="TBU21300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUM0"/>
    <dbReference type="OrthoDB" id="2750360at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597638" description="Ricin B lectin domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="83"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="16638" checksum="27DE76E4911862C1" modified="2019-07-31" version="1">MKAFFALAVSALAAAPLVAADAITGARAAHFFSSQNSSLVFGPQSGAAKASLVAQLPGDGSSDDLTALLATGGTGVPGQIVYGDLCITANGVEPGSSSQTLYVDDCSDDPKQIWTVNASPATVSNADGNCLTLGRAANHVPITLSQCNDVLQHLQLWNPVNVPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVH4</accession>
    <name>A0A4Q9PVH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_977267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVH4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVH4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19931" checksum="507471EFADC93A30" modified="2019-07-31" version="1">MVMTLPLTIPGAPSAGNCPTSMNHSQTHVSPSSSVQPLALRLSRVLPPLRVRHKRKPSRRASTTERRATYNAVDCARRKTLNGLFSGLVEEDGADGDYADNDYGDDDVAGPAPDVDPFAHNVSQCAYLQAQTSLPHPATFGLHAPIIVQSPSAVSFENSITRYDWHPHAANQMHAQFMGQYIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVJ7</accession>
    <name>A0A4Q9PVJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_948683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVJ7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVJ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF8">
        <property type="entry name" value="ACYL-COA SYNTHETASE FAMILY MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="533" mass="58256" checksum="918BE65BF9327BA5" modified="2019-07-31" version="1">MTPHPTPQGVNSPTFNPVPFNHSFSVPGLYEHHAKHSPDHAVFTYTDLDTHTNHDISYRQAWQSISTVANMISAYYDGKKAPAADGKPPVVGVLAMADTLTYIYVLVAIMSLGFTAFPLSPRNNPTVTAHLVEVTGITKVLVSEDLAMQTLIKEASAVLTKKGITIEPLLMPKPGDYADASGMRTVKEIGDNDVTIILHSSGTTAFPKPIPITRRGLINLSNIPCYGEVDLAGKRIAAHTNPTFRTGSTFALYKPIVPPAPPNPANFLASWVADRCDIVFCVPVFIEAWARDPANIPTLQKLDSIVFSGAPVNKGIGDMLVKAGVTMHPFWGNTEVGPATMFVPEDSPRTDEWEYFKLSHHIKFYMKPEEGLEGIFEPIMIHVFAIGDLLELLTLAAGVFLDGRTTRLCCRPGRTAHWFTSIAQDPNVASAVMFGRNHVDVGVLVEPAAGVEVPLDNKQKPTIELVNSRSPQYAQIKKEFIVVTSPSKPMELTAKGTPRRGVCLKLYTEEIEALYAAVEQGIDHANRQFPDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVQ5</accession>
    <name>A0A4Q9PVQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase S8/S53 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_851128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVQ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020606967" evidence="7">
        <location>
            <begin position="18"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="9">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="176"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU58464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="506" mass="53492" checksum="25246EA8870CD045" modified="2019-07-31" version="1">MTRLLYVTLLAVSLVSATPLSTYHDSPRRVSGMTVAPLYVEEHPHGTVNNSYIIMLKDGTAPTLLANHMNFVQTVHAADPEANAFAGLTHVYDGHILGYAGKFSKNVIDHIRMMPEVDYVEHDQVVRTLEVERHADFETEKHATQKGAPWGLARISHRAKLTFSTFTKYEYDTDGGAGVDVYVIDTGINTKHVEFEGRASWGKTIPQNDVDEDGNGHGTHCAGTIASRKYGVAKAANVIAVKVLGSNGSGTMSDVVGGVTWAAKAAADKAKAALEEFRRTGKTSHKGSVANMSLGGGKSRALDDVVNRAVDNGIHFAVAAGNDNKDACNNSPAAAEKAITVGASTLGDERAYFSNHGPCVDVFAPGLNILSTYIGSNSSITTMSGTSMASPHTAGLLAYLLSLYPSVTFNPSVAPDLAALKVQSLSTPSLANAYALAYQAMPSWVATFLPPPELVSQEPAFAPVPIPTLSPAQLKKALLALATEGVFSELPSGTPNLLIYNNATIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVU2</accession>
    <name>A0A4Q9PVU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_948544</name>
        <name evidence="2" type="ORF">BD311DRAFT_672787</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143490">
        <property type="protein sequence ID" value="TBU23989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVU2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU23989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5848" checksum="9FCF6A977CA6E192" modified="2019-07-31" version="1">MAPPANLQNLTAAQVQRCPTLLVSAFKVANDPDEDDEHAAEATKNALDSKVKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX65</accession>
    <name>A0A4Q9PX65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_925734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX65"/>
    <dbReference type="STRING" id="114155.A0A4Q9PX65"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20296" checksum="2AF1A534422E89F1" modified="2019-07-31" version="1">MKYRSPSPDNALPTPPQSPTSPDGPHPAVSLLESLEAFYQQERYWVHHTRAALELAITKGIDAPPSDHSNTPSPCASQGLLSPASTTSSDTAVSVIKSEPDAPPPSLSRSDATRWMRRKNTMRLKLDGVSLHARKRRPVRAPPTEPGARLLEMFSELMDARMESCQRVQRLVRNANRADLHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYE9</accession>
    <name>A0A4Q9PYE9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_373813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYE9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14246" checksum="430857E501F4FA08" modified="2019-07-31" version="1">MIYAGVRSAHRDSKLGIWAEAPRQPNRRVCPGIAMVAQSREGRRGDVRCWHCRVMAASLEGTLKGGREHRHRGVCYQVVLILFTLLTFQNVYVAMASSLGVQKRAQAEPHAVVGPHRLLTFADSRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYM3</accession>
    <name>A0A4Q9PYM3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYM3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYM3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="422" mass="48665" checksum="F3686F270C2EBACC" modified="2019-07-31" version="1">MPSALLKHSDHPTTEKSEEQLPDITEEEWQTENCLPNWPIAFWQGYRSWLRAHSISLYDLRIASEFAMSEQWYPPRSTTPAQFPFATRLYVVSTTPLGRDVRYRFGFGQDLVGRDVCIKITTKGSAEHQINRYLLEQSRSSTNAPPSYTLPPVAVLDSPYHFSFVVMPMWSNAFLVESFDSVRLVMTFIRCLLTGLSYLHDHRIAHRDIRETNILVNGYCPELEAFESKAIVAEHLHSPDVAFSFFDYDLAIQLPRNVSVNESRRPAWEGNRGSPEFHPPDISLAQPEYNPFAFDVACLGNMFLHHFTNVIKVVPELAPLFARMTTHIIDQRFTAAEALSFYNEHLSRLPDDLLAHPLTLFTSFEPLCDPDVYWSLLSSEDRGRWHAFRVPPRSWGHRLLAWIAETDLGWKILRAARRMLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ59</accession>
    <name>A0A4Q9PZ59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ59"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8725" checksum="558FD882478D659E" modified="2019-07-31" version="1">MASDARNQTGFPTRHVPQGPQVVGRSPHAQSQAERKQYGRLYTVEPHSTLKHSGRDARWTATGRVRPARFWELDSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZE8</accession>
    <name>A0A4Q9PZE8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_815623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZE8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="15721" checksum="7746EECBCE80E530" modified="2019-07-31" version="1" fragment="single">MPCNRRLRYYPSNSVSFCLLLAALFIGLPIVGAQLQIELTPNPPMQCVPWNFTWTRGTPPSTLQIQPDSSNTSVSQQYGPLTSLNGSVILSTNVSSGTTVRVVFHDSAGVTWTDWFTIQPGLVDSCLLSSGVTTPDAPSATTSPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZL2</accession>
    <name>A0A4Q9PZL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Squalene monooxygenase</fullName>
            <ecNumber evidence="4 10">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_957738</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="4 10"/>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZL2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZL2"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0492">Microsome</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="11">
        <location>
            <begin position="172"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU60253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="490" mass="54451" checksum="CBC1DCB3E34932A8" modified="2019-07-31" version="1">MTAQQRPRDRMWSASYDVLIVGAGIAGSALAHALSAAAVRRKRPLRICLLERSLSEPDRIVGELLQPGGILALKKLGLEECLEDIDAIPTYGYCVMLAGSPVHIPYPEGYEGRAFHHGRFIQQLRKKAKEAERVEVVEATVSELIECPLTGRVLGVRATRKEEGAVEKEAFFADLTIVADGCFSNFRNKVLGKAALQGVTKGHFVGMILDDATLPIPKHGTVMLVEGSGPVLSYQIGTHDTRILVDVKHPPPPDLKEHITKNIIPQLPASLHLPALKALSQDRLRRMPNTFLPAIQQGTQHTKEGVLLLGDSWNMRHPLTGGGMTCAFNDVVILHELLLDDVHDLADWAQVKPVLRKWFWRRKPLASTVNILSVALYDLFGADDPLLEVLRTGCFKYFELGGACVREPVSILAGIEQAPFMLFRHFFSVALYSIWVLFTHPRRVGTSADGKAVLRRPRPDEWPLLAVRSMQVFYTACVVFLPLLWTEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZU8</accession>
    <name>A0A4Q9PZU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZU8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZU8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="4"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="300" mass="33069" checksum="DE095A8E4AB30C75" modified="2019-07-31" version="1">MNDTPFSMQDIPGKGKGLIATRPIAQGELILAEKPLFFQSLRHSNATVLAALTSLSDADQRRYFSLANAWKGIHPPPIGIFITNALPCGENDAGKGVNAPKAGIFLDGSRFNSSCQPNVNNYWNEDLQKITFWATSDIASGEELCMCYGDTFKTREDRRRQLQSSFRFVCQCVACSKEGEALRASDERRAAIARLYDEIEASGNIPSLGVREVKMALRLLAEENLLERSVSFCIDAIQFCVSVSDIKNAKAWAKKALEVSILTTGPNSKEVKTMTALMEDVRQHRSFGLLPRAKLSGPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0G7</accession>
    <name>A0A4Q9Q0G7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_319760</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0G7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0G7"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000108">
        <property type="entry name" value="Glycerol kinase, glycosomal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU60505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="534" mass="58320" checksum="5F7CED09335A968C" modified="2019-07-31" version="1">MTSLKQGEFVGSLDCGTTSTRFLVFDKYANIVAQHQIEYPQYYPEPGWHEQDPDELIESCEVCINEASKVLEAAGWSKDSVKAIGITNQRESAVAWSRKTGKPLCRLIVWDDARTKNTVAHFEVKLKTVGIEVKPGEFKKGDEGIDALRKLSGLPISTYFSAIKLRWMIEHHENVRKAHDEDDLLFGTVESWIVYRLTGGVEKNLHITDVTNASRTLLLNLNTLKWDDSLLKFFEIKPSVLPKIVSSSEVYGELANGALKGVKIAGIAGDQQAALIGNKCLKQGEAKCTYGTGAFLLFCTGDDIVLSKHGLLSTIAYQDGQNGKPVYALEGSIAVAGSAIKWLRDSMALVTSAAEVNTLAESVPDSGGVYFVTAFSGLLAPYWDPGAAGLIIGLTSYTTPAHIALATLEANAFQTRAILESMKLDSKSELKHLKVDGGMTNGDKVMKVLADIGGFTVIRPEMRESTALGSALLAGSAIRLHGWNISEPETLAEVNTKGNKEFTPTMPEPVREKRWAGWQHAVERSRGWEEGKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0K2</accession>
    <name>A0A4Q9Q0K2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0K2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16704" checksum="F9452B3D98BAB6EB" modified="2019-07-31" version="1">MVTATLCSLAHTPDILYRIFSYFDTDDRERQYLPGNVYESRRSLVFAAKTCRAFADPALRVLWSSLPDDQPLADLLCTLDIAARERSLDNQGLSEGTPGCHALRDQYGGFGLYIPDYTYEPRWRQSRGYDVSYFCPRGGDPRRHPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0N5</accession>
    <name>A0A4Q9Q0N5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="9" type="ORF">BD310DRAFT_875120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0N5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0N5"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25399" checksum="05D689B1EAF706F9" modified="2019-07-31" version="1">MFSASRPAFLRPSIPRHLSSRLLRHHASSSAYLHPALASDPSVTTTPENISPKLRHELESALRVDQAGELAANYIYKGQHDVLGRQPLTGPLIQEMWDQEKKHLAVMNKLQTQHRVRPTLLWELARVGGYGLGALTALMGKEAAMACTEAVETVIGEHYDDQLKALEELPPDHPSVPLLKDVIREFRDDELEHLDIAVQNDSQKSPAHALLSTVVGTGCKVAIELCKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0P2</accession>
    <name>A0A4Q9Q0P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_329212</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0P2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8533" checksum="DA145FD23013A845" modified="2019-07-31" version="1">MGGRYSRHTLWAVASGVTLVHHVLRTENLRTSFHQRWGVRHDYLEIRHEIMICQPCSSGAEISFINYSTVTYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1F4</accession>
    <name>A0A4Q9Q1F4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial DNA polymerase catalytic subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_966268</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q1F4"/>
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    </dbReference>
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        <property type="term" value="C:gamma DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002297">
        <property type="entry name" value="DNA-dir_DNA_pol_A_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001098">
        <property type="entry name" value="DNA-dir_DNA_pol_A_palm_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041336">
        <property type="entry name" value="DNApol_Exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10267:SF0">
        <property type="entry name" value="DNA POLYMERASE SUBUNIT GAMMA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00476">
        <property type="entry name" value="DNA_pol_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18136">
        <property type="entry name" value="DNApol_Exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00867">
        <property type="entry name" value="DNAPOLG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00482">
        <property type="entry name" value="POLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="523"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1278"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00031966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1337" mass="150263" checksum="B076CAEDBF387AF4" modified="2019-07-31" version="1">MWRKLQSSSSTPVSRSIHVSAPLAVLQRKPLQAKPPARKRFQKRSEELRDDELRQGLAEQGPKRNEVGVQLLSRQLHRQVFRNVSFPPPPASYVRIAQEHLKMHGLDPAQGSVLPNVGFTLPPLQGRTLDEHFYRIGTSAAQPWLTLVQDLAAARIPPKPDHWHIQSGWTRYTFLPDGSSYCEHVEYPQFDGKPEEMLVFDIETMPRYHDYAVMACAATPNAWYAWISPWLLGESEDPQHLIPMGDPSVPRVVAGHNVSFDRKRVLEEYNIQPTQTRFLDTMSLHVAVKGISSHQRPAWQKYRKSKAREEEQTREAYEAFESMLAKGEAEIERETDPDRKAHLQNLYNEMEESLPMLRGAVETGEIEQSEDVSERWEDKTSLSSLADVAKLHCGIEVDKGARDDFLSETREAILEDIHTYLDYNATDVEVTHAVFAKTLTAFLAACPSPVSFAGILTMGSSLLTVNEEWEAYLANAERAYKELEDRIKKRLIELAQQAKTMMENGKWKEDVWLAQLDWSPKVAGKSRGVGTSEVSPTEPAAGPPQPPPEPIAVDADAPSWYRDFTVDPFDTTVVRRILPLLLRLSYDGYPLQWSSKDGWHYLMGGEVIRLSAGSGKVVSILGPSHGLPALAAGKLQSIDRELAKNICKGWRTDDVKDGLLRLAKAALQTCPARVETDPWLQQLDWSIPDSPKRPKRKPTSLKPTPVYWPRWYWELAKPKKDCPPGTLDLTVRNRYAPLLLRLSWQGWPLFYSRGHGWTFRVPIKEPFETRASPLAFDDNVDPQLHNLTAHFNFYKLPHKDGEDANVGSPLGKTFMKYAQDGTLASPFEEAKDALDMNAQCSYWISSRDRVTKQMVVWQADNLDIGVPRPVEPERKWGIILPQVITMGTVTRRAIEKTWLTASNAKQNRIGSELKAMVRAPPGYAIVGADVDSEELWISSVMGDAQFGLHGATALGWMTLEGTKAAGTDLHSKTASILGISRDQAKVFNYSRIYGAGMRHAVLLLLQGNAGMLPEKAEELARNLYASTKGQKSYGTRYFDRKFWYGGTESFVFNKLEEIALSDRPRTPALGCGITHALSKSLLPDEFGSDFMTSRINWVVQSSGVDYLHLLIVSMEHLIAKYNIQARYLISVHDELRYLVKEEDRYRAALALQVANLWTRSLFAFKLGLDDLPQGVAFFSAVDIDHVLRKEVDMPCVTPSQPNPIPPGESVDILKTLEKTRGGSLWQGGEPMVHNDGLDCESSLFGYSSPDCLAHRANSASWLRAQSTSNFDEVKSLAESFKRNGPSTTAPKSKARSTRRSDIQRLKKARSLGDGSQYDWGAIAEEMLQAIRSDRQPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1F6</accession>
    <name>A0A4Q9Q1F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DOPA-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_921947</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1F6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1240">
        <property type="entry name" value="DOPA-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023389">
        <property type="entry name" value="DOPA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014980">
        <property type="entry name" value="DOPA_dioxygen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36423:SF2">
        <property type="entry name" value="AFR070WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08883">
        <property type="entry name" value="DOPA_dioxygen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143410">
        <property type="entry name" value="DOPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18733" checksum="A0AF1CD8535A6E58" modified="2019-07-31" version="1">MSEYTSPLIGYENAEPLPTTFNADGKSLYNPPGPRSAAYDEFPKPIDSSNNGFDFHIYYLPNAPDEAKFAAELHERIRREFPELRIYRFWDKPVGPHPVPMFEVNVFNPHQTGTLFSWLVVNRGPCSVLIHPNTGDALKDHTELATWIGKPYPLNVRPLKRSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1I5</accession>
    <name>A0A4Q9Q1I5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_957158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1I5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1I5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019152">
        <property type="entry name" value="DUF2046"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15276">
        <property type="entry name" value="H4 D10S170 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09755">
        <property type="entry name" value="DUF2046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="294"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="438" mass="47867" checksum="35B3178236D2074D" modified="2019-07-31" version="1">MSISPPIRRLSTNSSSREDLINQYEAEEERIINILSRKLEQLREEKIELENVLEAESESHVNRLSRELSALRLSQQQQAGPSHLNGTDSGSPLDARIAPQLAHLFSRSNGGPSSDMILDALRRENEALRSRLVETEQDFIRISRLNEVYREELIQHRRRLGLPVDSLIGLPQSEPFSQPTHRRSSTGSSPSSSVHIPSNSSHPARHASAVPIPRPPSQIRRPANTISSESTTPLSHSPSSVSTSPFPFSPVTTSPFPASYTSAVTNLTTPPSIGSVAVSPPTFTAGGTRMLSYPSVPPPSLSSSFGSPSTSLHQTWTTSHPISSTSQDHDRTPSPVESFHSRRNSFNRRGSSERRVAETGRLRRSMSRGQSHSRRESVERGARIAETGSLVPRNRSASFGLPETIEDADPNVPSVLPRDAERGPGSKPTQVPTPQPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1R1</accession>
    <name>A0A4Q9Q1R1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_238195</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1R1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1R1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="186"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="299"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="816"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="915" mass="97820" checksum="AA78E5E8F50D114B" modified="2019-07-31" version="1">MSSSPAQTQLSPARSPSLSIAFPRSPRDTPATPPTSSSCSPHAPPTPPDSSSRIASLFNTSPSPRSNSSLNTSSDFSLSTTLSTSAPQFQPRLIDTPIDLHCLAPDLDSPPAAQDSGPIGTRNDSVNFKAREQGSPTPTQEAMAHRLSPDSLPPAFVPAAAARAQVAREATEDEQTDSSDSDPRPPNVYINGLPPNFPEEELLAMTRPFGPVLSVRTFTRHVSDKPSGYGFVLFERLSSAEKCIESLRKYRNLHPSFSKQLHKIPGTPYASVPPSLTANTGPTDSFKAKMEQLCDKSSTNLYMEGLPLDVTEATLHALVTPYRIMSSRFFHTRLSSPPRIIAFVRLETRTAAEDIIERLHGRLVRGWNDAGCRISVRFADTAEQRELRRNERQNPEGEQSPARLTMARAALLNLKGTQYQGPGLSPTLSDVDLGSLQNTTNSNLGLAYNQFGLGQAGQISPIGPTSPLPAQDAFLRGGIGLQETSALGVNMPSLDTFSTRNPYVSAQTLRLPHQDLPADASGLFDEQAELQLALMNMQGARAQSGYTPVEQLILQAHVRQRRAHAAAPHHDSVPARAPNPRSGHPRVGRSANSGYGANRRLLDFLPPVSEDDFPATAALVPNHRTLSQAMPEEIGLDAFSRGGDLSCSTRALDLERQVPLSGQPTRQRVHTLAAQVRPDVDSQGLHIRSSTLPTQYLNVRNTTRPSNINNPLYDSSISLAGNVSSSSSRRTSNVVRVNEIHVSSTQQSSYSPSNGLTTTRNARTLGASALADTQTLFTSKNNVNISSAASRKSTMTDADVKTSSPPSTSIIKPPNGATSGSTSHPGGVSMSTSTSQDADDEDEGSCVVSPALTYSSRTPASLSPATPYSGFFSENGETFKNAGINVSGTIGPVGPGDVQPDMSEVKKVQVQGGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2V1</accession>
    <name>A0A4Q9Q2V1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_845680</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF511">
        <property type="entry name" value="LACCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020853366" description="laccase" evidence="13">
        <location>
            <begin position="21"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="33"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="162"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="370"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU61465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="521" mass="56877" checksum="4DF2BDD76EDEC5CB" modified="2019-07-31" version="1">MKHPVFLMAALAYLVHRCSAQAGPITTLNIVDAAVTPDGYTRQAVLPNGTFPGPLIIGNKNDNFQINVIDLLTNETMLTGTTVHWHGLFQHSTAYADGTAFVTQCPLTPNNSFLYNFTATGQAGTFWYHSHYMTQYCDGLRGPLVIYDPEDPYLSSYDVDDESTVITLADWLHIAARLGPRFPTPNATLINGLGRYTGGPAEWPLSVITVEQGKRYRFRLLNMACEPNYNFTIDSHNFTIIEADGEYTGPLEVDFIQIFAAQRYSIILNATQAVDNYWIRANPSVALPDGQGFAGGINSAILRYVGAPDSDPTTNQTPSVIPLNESNLHALVDPIAPGQPFPGGADVNINLDFTFNATTQLFYANNVSYASPSVPVLLQILSGTPGALDLMPAGSVYYLPPNKSIEISFPALPAATPGEPHPFHLHGHAFSVVRSAGQVTPNYVNPVRRDTVSIGEVGDNVTIRFETNNPGPWFLHCHIDWHLEAGMAVVMAEDVPDIPKDVVPSKSWDQLCPTWSAYGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4U7</accession>
    <name>A0A4Q9Q4U7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_844517</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4U7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4U7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="7">
        <location>
            <begin position="205"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="475" mass="53261" checksum="3D1A18659E52DA64" modified="2019-07-31" version="1">MASTLFRRQLARAPRLSSPTAPRPSSLLSAAAARRHLSRSAVAQAEATSSPATTRGGKNVFETHTVEDLHGLHAAEILAETGSRPETQLRHFTVNFGPQHPAAHGVLRLILELNGEEVLRADPHVGLLHRGTEKLIEYKTYTQALPYFDRLDYVSMMTNELCYSLAVEKLLNIEVPERAKWIRTLFGEITRILNHLMAVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYVRPGGVAFDLPHGLLEDIFKWATQFSSRVDEIEEVVTGNRIWKERTIGIGVVTAKQALDYSFSGVMLRGSGVPWDIRKVAPYDKYDEVEFDVPVGKNGDCYDRYLCRVQEFRESLRIISQCLNKIPTGAVKVDDYKLVPPPRASMKESMESLIHHFKLFSEGYSVPPGETYSAIEAPKGEMGVYLVSDGTNRPYRCKIRAPGFAHLAGADFMMRRHMIADVVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Y6</accession>
    <name>A0A4Q9Q4Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_919679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Y6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="248" mass="27750" checksum="BDE8E676E7C8AED7" modified="2019-07-31" version="1" fragment="single">YLMHSRTSASSRVLKQCRTSPLSSLPSSSHVRRRFLSRSTTTRTSSFPHARFRSSLVPSSTALRVLLLALSTSSHFLLGSCKKRKGKVRTGFDRAWAGLEHTLAEEGSNSLRNTSACPGFHCTGYHSTSRQAAYQCASWSFPPSSSNIPSLSFACTKRPPSSTFPCGVTVRLLLTVDVPFKLPLSHRATCRFPYVSLSFASSRYPPRPDHTCAIHPPSLRHFIPPRHFPPDVRRLSPEVLRFYPYRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Y9</accession>
    <name>A0A4Q9Q4Y9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">T-complex protein 11-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_811077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Y9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4Y9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="520"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="653"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="772"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="867" mass="94087" checksum="E32EEC3F42DC35D8" modified="2019-07-31" version="1">MDDLAHESRPIHSLSRKRKADQDDHNGPPSPSDPPPTPDAMLIDPQATPRCPADAATPGPSTSPWHIARSTQGMAPSWPHPPSPSCAPSAFNPQRNREGQASPKRLRIEIPCTPPGSPRSRRLRGPSSRHHLGRHRRAGETRDTGIVSATEPGPSRGSLLRTASLPSVSSSSRSVPASPVEPITISPHIPPHQPPINRETLKELDLEAILRNPQLRHDLLFDSGLQFRPTSSRRKRDLADNYWLAIVRELECGCTCTTLDANGRLTERRCACGILSMPIDRPLLAFSQGNMMTVRTPSRIRPLLNELLEVLISIIQPPQPPSTRPPGLLFPPPPQHPQFQQNVAHVALLRQLLDPDLIQQEIDHGLFDPSGVFQAIGDIIRCHCAPMRDAAVDQMVALARSCAPGGSGTKLDAVRAIRLCFEIMELMKLDVANHQLQTLRPYLVRTAAQYEIRTFRETRQNRQTTSLGLTRAWLKSAYRAAAEGSSLHSQRFLRHSRQTRVTIAVVKAVVNLIFDPPAVPSPVSSAPSPSSPSSSAAASTPAPSAVSTPTLSSPPIASSRSHSSSSSSSQFAGYPETFFLDYGRLATLSTDAADFTALYMLLMLYRQLVHSHAHRQSRGGARAQVTNDELLRLKKEIWEIGPSHLGLCYMQNRPRPSSSSSSSRGSSSSSPSKHERGERDREAELKKWRADIGDVVLQVTMRATEPRPLQQNLGGEPPARSAEALRAPDASVLSLANSWAESNLRAGSPLSTLMKKRIRECVEEAVLDIVLSPPSSSPASSEPDEPSENDAQSSSSGLEPLMPEIRHLAERAAKLVSIHTNVYGSLYAHPAFLGLDASESESEPCPSPAPALLSATPAPAPASASMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q512</accession>
    <name>A0A4Q9Q512_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_176997</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q512"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q512"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="392"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="699"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="825"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="840"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="862" mass="94035" checksum="3BC740F5DC42D1E2" modified="2019-07-31" version="1">MSTSRIESVDYTHDIRPYLQLTHLLSLTWLAYPILSLIFVVFRLQLSSTSAQDAVANAKNDLLASCKAAEHAATTAASMPRYLAIATNAQITDAVNGTMNAARATMVLALTIMETIINFVIDIYRSTFLCFIELIVRAVLSLLISAVNEANSLIQDAAGPVADALDAAASAVNDFIDAASKVIKTVSFGSISIPGHIDTSGLNSLRNFTLPSSLTDGLESLNNSLPSVSDLKDKIDSLVDTPFELLKKDINDTFGGLSFDVSALPLPTQNTVTFCDQMDTSVVDDLGRDMVKVVKIGTVIMIILIVLLIAANCALEWYKWRAMKTHFQRIRDGLVADPDVKTQRGPDGRLMVGMSDHDLMSVEGTMSHPLVMKVVNKFELVFKLRKSKKDKLIWFSHYVFHPPAMACFLIGFFGLLSVELQLLAIGPIQAKFEQQTAASVSDFSGVIATSINASMYNQSAAYATQINTRVDTVQSTINDGLFGWVNSTTTTLNDTINTFYTDVQNVVNSVFNNTPLNEPLQEFLRCFLGSKVDAIEDALTFLHDNLHVDVPRVNDTVLVLSPASVNEAAQPIAQAAVGTGNGDDTGLVGRVVEAYVKSLKQERIMFAIFAGLWLFVVFMALCILFWASYGRPMLMRARRRGGGPNDRDRVDALYGGYGSGKHVEAGEKQDLYEVQLADADARDGKATASRGLFWSSMKGPWRRDARSPPQVDGDLSQPRPLMMQNPVYQKSWDNILDNADPSAYEPEGEPSSKVGKSRKLMALGRKGMGREPALKADDDGTLAAFEPQNEAAQPAKGNWRKLFGASKKADAAAPVVEDLPYVDEREVTSSAAQQPGGAEYRSRFHEHVSSESLPGQYPPDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q573</accession>
    <name>A0A4Q9Q573_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_55457</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q573"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="325"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="463" mass="49534" checksum="B20F7A84DD8C6826" modified="2019-07-31" version="1">MKERSINLTPIPFSKYSGARMALLFWGIAWFAMSVVIFILGRIIPPLRSKPPPLVLKPRSPRIRSASLSPATAPIEPPKLEEKDDVESTKSAPCDIRSAPPPVPLTSKRPSFRKRWSLSKSSRPPSPKSSAGSVASLTLVDNSSPSRYVPDLPSIEGESGMAANFDQDDTHSTDSPTGSPRLTRNVRLPTMKMLKSLSRKVSTKPRSASAPSSSVAPLGSTSPLEDDAREPVKQARRSQSRERPAPSVIAPESDIRPQQRTDSISGETFTTTFVNPFRLKHRNPKASITPTNPPFRRASGPRRMLNSLSLTLASKESRKTPIPDSPRSSISTSASTSTFSGSSVTSAFSASSGSPSVRRTQPYAAPYYAPMPVSSSVPTPLGGRSCSGSAPARRRAASCSPEWRPEPVEEESGEAEDANALGLDLAVGTQASREARAGLHGRQSGHRTAASESLVVLGPAGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5D2</accession>
    <name>A0A4Q9Q5D2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_945763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5D2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF452">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020208149" evidence="6">
        <location>
            <begin position="19"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="494" mass="54681" checksum="430DF78FCFDF93DE" modified="2019-07-31" version="1">MRWVSALLLSTTLLGAAANPLVGSDAVVGVDNVGPQHILAWPGVEHTAANSVEEHRQEEFRSTITSVNGVVYQQFAHPAFSDHRLRVTSPEICDPTVKQYSGYLDISDTRHLFFWFFEARKNPDSAPLMMWLNGGPGCSSTTGLLFENGPCAVTSPNTTEWNPYSWTNIANMIFLDEPIGTGYSYASDHSKVDTLADLAVDVYAFLQFYVHKMNKRRIYAPFPGQRHINFASLILANGLTEPATQFESVPEYLCDKSPYPPFEKDSATCRMLRAEAPICERMIESCYRFESLATCVSATGYCWARVLGVGGNIHYNPYDIRIPCVDPDGVCYEEIGWITSWMNKPDVKRALGVDHSPIDFLACNMTTNAGFYTQGQAMHNSAALLPELVEAGIRLMSFAGNTDSVCNHIGIENWMLKLEHKHHEEFLSAPFLPFITDVTGDVGGKVRTAGGSGAGNVTYVQIFDGGHMAPHDQPEATLDMITRWVRNIPFDVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q639</accession>
    <name>A0A4Q9Q639_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917391</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q639"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10843" checksum="2AF955974F812042" modified="2019-07-31" version="1">MAMRTRATNLRIPATGTISSLVGPDSLVIFQSRSRCRVCLEATAIASRPKNTRRSVVSCLLELALYRVSCYRYHASFILVGPVDIGSSSAVGFILTRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6L9</accession>
    <name>A0A4Q9Q6L9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_955985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6L9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6L9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="76"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="541" mass="60889" checksum="5243344E610D868B" modified="2019-07-31" version="1">MTTLFSDAERQQFRIEPTPDVVQAAEDTILSHEREIGGLEERIAALLNQVRDLRYEQARHRAAIARCRGLVTLARRLPEELLIRIFELLVEDGWTRAPVVVSHVCSAWRRAAGAPKVWAHVYVRCDDANVHERTRFWLRMARGADLHVTVAASWRIPQWQIGQLMGLLVERSGQWRSLRVETDSLRHAELVLGQCDRPLPELRSVAIKTAAIDSADAGVNDLSILTERFGDERAPRLARVEYASSVIPRFPIFPAHITSLALDIYESNPHRPLSIASIIELLEQLTQLKSLALTMPLAYEAAFVPLPDDDLERAVSLPNLNTLVCYGPTDLNELLPHIHAPALRRLHIRSLEDVGYRQQPVGPSLLLFLERSAPPLELLELHDIDLSPETFAAVFAALSGTLRELRLHESSISDATIQLLHGPRGLCPHLTKIDFRWCGMLQGRALVDWVRSRCAVDDIPEGRIGEPIEEVGVVNCAFVLEEDVMDLARMTVCRIVMRDGDDYCRSRGLGCCSNGRYRTRLRMRHLTDLAAGRDTGIRLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7I5</accession>
    <name>A0A4Q9Q7I5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_809648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7I5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7I5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="480" mass="52029" checksum="C3295FA5C803BDC3" modified="2019-07-31" version="1">MSSATDPVNLRIGVPASFEGSTLAIQCSTGGFASANLRYQCNEAAGALVVLKDPAHKTTMECKMRIVQYIRLHLSSWLAFANDELGLGLEKDIIFVSGFTKTNSSASAELVVSGGVPSASGEFRVSLSQSRDTCVQSRIGPASRKAAWGGESDPVEKCDQCIFLNYYKSKSRKLLPPKIIKAAAGPNDLSHDDDDDDDDDDDDDDDDAPETSSSSSDDEDIDDVGEKHQADISDLQEYEPVNFVLDYILKHSDAETACASDAELTCLFQNQTLPNDLGAALESLSPTIFVDEGGTGRIQASPDVGKEIAMAAPPFQGSSLECNQRHGECVTFDDLLWRVSLAADAHLDSDDSRRESTADFPNPVHAGMQSPSCQGRSKTFSNVPSRRALLIGIGYGSGEQRLVLDKYGYQKENITITLDNDSSATASLRPTRVNILKEIENLVQFARPGSELVFYCEASVPSRLTPEADAPIRFWTWLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8R3</accession>
    <name>A0A4Q9Q8R3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_1021563</name>
        <name evidence="10" type="ORF">BD311DRAFT_699803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143456">
        <property type="protein sequence ID" value="TBU25726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8R3"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
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    </dbReference>
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        <property type="entry name" value="Pur-cyt_permease"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 9" id="KW-0472">Membrane</keyword>
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    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
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            <end position="414"/>
        </location>
    </feature>
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            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
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        <location>
            <begin position="467"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU25726.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU63446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="539" mass="58750" checksum="FF01D21C0308A86D" modified="2019-07-31" version="1">MLIFDDIESTSEKEKYPPSSNASAHSRESKENLPDNVLVVEEENVVQEAKTKVGRLLHRLTVQLARWGLEVNGITPIPEDQRTDRRLYQFFFVWFSANANILTLSAGTVGPAFFNLGILDSFFVIVVVDVLTCPFPAMFATFGPKLGTRSMVQARFSWGYYGAIIPSILNVLSMQGYLIVNTIIGGQTLAEVSDHLNATLGIIIIALISLIITFCGCKVLHWYALLIWIPNIIAFIVMLAVGGMQLREAPLTSVTPASAATLMTFGASLAATVVSWATLTPDYGVYHDRKASTWRLFFYAYLGFIISSLPAHMLGAAFAAASQSVPSWSSGLGDGNDVGGLIAAVLAPTGKFGKFLLVWLSLTAPSACAPSMYTACTSFMTIHRAFARLPRFVVAVISTAILIPVAIVGAGRFYETFETILALIGYWIAPFCAVVLTEHFLIRRTFAAYNVPGAWDNPRHPNLPTPYPALCAFAVSIAFIVLCMQQQWWTGPVARQGTGDLGMLLGFVASVPVYAGARYAELNWSSLKKRMGSLEGLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q911</accession>
    <name>A0A4Q9Q911_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_916630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q911"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9207" checksum="98D071B61E54951F" modified="2019-07-31" version="1" fragment="single">MKDLQSTPRNHFDAKLTALARDNFRCMVTGRVDGSSLMNGLITCLPGEITTMTQCAHIFPDSLGDLQTGGSGNKEHQVATAWTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9K6</accession>
    <name>A0A4Q9Q9K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_808346</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q9K6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF9">
        <property type="entry name" value="FAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
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    </dbReference>
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        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="83"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="291" mass="31876" checksum="3430757867CEA8A5" modified="2019-07-31" version="1">MVQRPKVTVATEYGNPLSFWVEYPNGLVDVTRTTHLPKGHLASGDVAQEQVASEVPVPPLLKNAQLDIPVDGDRHVRIAKEKSAIVIIDMQNFFLHPDLRDHPTGLDCVVPLMNLVPALRAHDVKILWVNWGLTDHELTTIPPSLVRGFMKSGRGGFGSQLPGPFGRLLMRGEYNSELYGPLQGLYEEGRQEGTDVWIHKNRMSGIWGGQTALDLYLQEHGISTLFFAGVNADQCVLGTLVDAYFRGYDCITVEDCIATTSPAGALESVLYNAGGSYGFITSSERIIKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9V2</accession>
    <name>A0A4Q9Q9V2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_807712</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9V2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9V2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394:SF29">
        <property type="entry name" value="MYONEURIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24394">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="252"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="358" mass="39839" checksum="9230723B9FAADB05" modified="2019-07-31" version="1">MDCDEPGSPPMFGIIVDVNMREHAMQELSPEFYVNPADVMARFLRSANPSPELTPKLDDEDCDMATLLRSEQMSPVPDYAADFPDDAVIHQDFPDEAISAIVSVLKSATTSATAQGTCAASPSATISLPSQAFTQSSEVVAPRPVYALPLGELRVPQQYTAPTYVPYPPAAFPGAPTYAFPSAPVPQQGHAQSQFMDVPQPVLNAHVGITLEELRQRATEYRARHPSAELDKAFLQSFAGRLSSRGELLDDYRCYVVGCGQRNKRRDHILVHVGSHVEHRPWACQHCGMKFLRKNECKRHESSHEGRKPYSCEICAPFQERSFVRQDLLKRHLRVSHGVHGTARKKSANKGEDQDYWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9Z8</accession>
    <name>A0A4Q9Q9Z8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9Z8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20372" checksum="B2E166D51AF5C710" modified="2019-07-31" version="1">MLQSSPEDSDLVRQHHNILQPENNSGEKTTLTKEAHSGQHLTSRGGSDGRNPMCSGSETCQDAGVSGCVGTLLRHQWCFSCHQCARPTHTGPLTCSCSWRAFNAMRSGNDDGGNSRRYPASRSLKRSGRTSADTILSEIQRSPFPSRRGIQRRCFNQMEKTISKKTVSGRNWIVRCPKASGALHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA85</accession>
    <name>A0A4Q9QA85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_398983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="960"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="318"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
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        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
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        <location>
            <begin position="635"/>
            <end position="657"/>
        </location>
    </feature>
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        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="970"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1022"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1155" mass="121281" checksum="BCBD5981B1941CA2" modified="2019-07-31" version="1">MRGQSIPGWAFLKGEASATWPNSLSVPGLTLHTPPEPSASSGAPSKDKHPTQRSQLTQESPVQSAVSSNAMGPPPSPGPSSKHNLGGGKSGGHYGTRPNRPVSGGPPPPARARRPHSGTDEEEEQPKKKKKRLLVNATPSSSRTAVLPAGASRSATYEKHLLKQPPSSAPAGTSRDAASQNRRATMDTGQLSRMRAQRIVERLNPHPGVKQKQANRSGPTTSRVPSSSLRGPLAGSSKPAIGSRVPSSSLRSQPPLAGPFKPIIGSRGPQQGSRFSSSSRAAPDKSGSATQRPLSTQRRKSAISQYDVIDISDEVDEQAAPRAARQTSRRASAPAAPPDEIIEILDSDEEAQMLSSRSRNTSRDEKPESSQQSTLPRRRAPAPARYKEVDGCIILESSDDDEPPTSSQVPLKKPSSTARRTSPVQRNASEPSSRPMAHTQEQPSDVQIPVPPPEQRPSLVATPPPLDDMEMVDSPPAMFEVPEPSAAVDFEMADGASQAAGSEVRPERGSESQVALAPEDITPATPSSPSHEEQPEAEDLVESNQPLTEPSEAPISMELVTEEGTTPDGTPTLCSTSPSEAGMQPVPELSDPSGSDLAQDPNSLASTPPLPHIAGLRADTASPVSTVLDPGLQNLVISGTPPGSSGSAENVQSPSEGSTATQSSSRRSSSRTRSLRPSDRVPWKMRGAVHDGSTGWIRGALKKRSELQYRLQGTGKSSPLVSPGGDTSAGSPTFSTNALADTSLSELPKDTCVSTAAVHETQKGPVEDVQLSAVVSTSRLDEASGLHQVIDPEVVEGEAAIPEPQSSLPQPTPVVPSVEPTPSVATAEIEKLEIHRPGTQPSTPPLENSLPQPLGPTLSQVIRDAANQNARKNVIDLTFDKSDDDRAAEAAGNPAEKSSESRGEVPPFTRPRDVQVTPATAVQVAVTALSTTSPSTVRTIDLNTIRNVGKRQSYITQVDRLSPIKPTNAPQLQQPSPSKTTTPSQPEQPSSLKLSFPPLPRNVRRPSAPDALRSPPAESAAIDSNSQASAQETALPAAIPKPRLPRRDVIRNMQTASSSSIGSSAPSLVSFASTATHAATDVPEIEMVVVEAAPSVPARNRLLASDIRPHTAISPSGSGSPSTDTTGEEGRSLLYPSSTPEASPEAEVRACCLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAA2</accession>
    <name>A0A4Q9QAA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phytanoyl-CoA dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_839802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAA2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAA2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU64577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="34577" checksum="00887EF14E1EBE30" modified="2019-07-31" version="1">MSTKLEYLTEEQVNQFRSDGYLRLPSFLEPDEVEALLTRTRQLLDNFSLEDHPLTRFTTGDDNHVGDDYFLTSGDKIRYFLEEDAVSDGKLNREKQKAVNKIGHGLHELDPVFRKVTLENEKIRAVVRDLQFHHDPVALQSMVICKQPHIGGEVPEHNDSTFLYTNPPSALGFWIPLEKCTPENGALSFLPGSHLTTKITKRFVRLPEGGTGFEELIPPEQAPQHPEGKYVLEACTPGDLVLIHGSVLHKSERNTSTHTRFAYTFHMIESPPYAEYDAKNWLQPTPKTPFPHILDAPNSTVVPVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAZ3</accession>
    <name>A0A4Q9QAZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_867112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAZ3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAZ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000179">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.19, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="389" mass="40853" checksum="2B423012E8A17E1E" modified="2019-07-31" version="1">MRSAIPLASALFTAAPTLAAYNLIKEYQGSNFFSGWEFYGNYDNLTNGDVTYLDQANATASKLAYVNDAGNAIIKVDDTSFVPWNDKRNSIRIETYDYFPVGTVLLFDAVHLPYGCSVWPSFWTKGPNWPAGGEIDVLEGVNLMTANQMALHTSSGCTVDGTDCSSGAGCTVTEKKDSSYGQAFAAAGGGVWATQLDTTGINIWFWSRNDIPDSVKSATNTVDPTSWGTPSASYPSGSSCDISQFFTPQQLVLDISLCGDWAGLANVYGQTCGTQGQVNSTSCYLENVINNGNYSSAYFEISYIKAFSSQADTFVATVSGSSTGLVSQTATGTAATGGSTGSPTSGSNSNGNSTSTGSGSGNGAAETAPRVYLAIATCVLFSLFNWAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCW2</accession>
    <name>A0A4Q9QCW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_972503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCW2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="824"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="890"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="977" mass="104765" checksum="6B3D4ADAFA43D696" modified="2019-07-31" version="1">MPPSASRRQSLTPYLPGAWPSCSRDQHDDTAQDADVSSVSSYGGSAITANARSRKEGSRKARRRWTYTGPVRPYVASSGPHGPPGLTYANVATLTSRTPSDPKLSPITISTALSSPLHTPDLADWPTHPDANGRLDRGISSNSTTLSSEFFPFSSDLGTSSRSPRLAPSASREHPFPSPHLDPPLLNFIPGLPPLKLPVHSSANNPFFPESPFAPPSPPLEACLTPASLAITPTGWESTPSISQSPDIPVEFLPVVKVTRSSSLPPTSSVSTDSHLSEADSPVLPSGSDAHAADSHGAVLAHLSIPASEMDAFALAAAVASSASRSSFSIPPSVQSGSHPSTPMESPEGTHRPDLGAYRHPSGTTEASAGHLVREEQLEEDRANVASEHTERVIARRLSAPQPTVHQTPRPQPVPTVSSRVAVGDGNGPLKRKVTKRPVMGKVRKLGERLRDLFKGRAEVPSKTLHSRDTPEYGLMTTTTAITNVEYESKHPIPSPSPRTKKLRNHRRSLPLPALLPTSINRVHTSISKRAALEHDSTLRTSTSSTRQPSALDGDDHCGSASPEDTVSPHSPRTPKGRPERTQTLLQPVLPVGSEGKPGSGTSNKARRFSLSSALSKSRMDSLRTTVIPRPPLPSLPLRETTSAQASTPDAGGLSTPRKSSSSPRQDRFWGGELPNTVGASSSPIAGSAGQASPVRSRTRTAPPQALSSPDTESSTAKDKRSRRFSLSSIMAKRSTRHLTTAGHISELSSPTSLKKTKGLSPRGPPRDTVTTVTHANVQFDMVSPRPELDLGSRPPLLDVAHIHRSSQVPSVISSTGESTYYDAKEELSEDEHCARRLHRPSASMSESDLDSMSFARTPDHSSGTFSFGSSTEREYYHQNSELSSESYTPYRSRRPSGPGYTRGAVGHLVGESTSTPVTKTLRFSPSLSLSFDLSCSDVDGDEDDLGRLDQEEELSFMRALGFEFDEIARRVREEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD67</accession>
    <name>A0A4Q9QD67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_911699</name>
        <name evidence="11" type="ORF">BD311DRAFT_783403</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD67"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD67"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU35771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="37720" checksum="1B9CE1F907727A4B" modified="2019-07-31" version="1">MSSSIPVSVDPPAPDPGPSSLSASRWPFSLYNRFSAWRKALDLPNPGTSENLTKEAKNTLLNNYLFDGARADLSKSLSMNPAFNVTHSFTLGSQTAPPAYHFGAIFANENLFLHGNIDNDGSMSGRINQGWTANNVTKAQAQLSSQAGQNFFQVEHDYQGSDYTLNAKAVNPSPADGTGIYIGSYLQSFTKNLALGVEAVLQRPSPDMADVAAAYMVKYTSTDRNWIATAQVQGAGILQATYWQKLSDKVDVAADLQLVAGQGRRDALASLAARYELRMASFRAQVDSTGKVAAHLEQRFAPTFSFLVSGEIDHFKNAAKVGVGVMIESASFTPEEMALMPPPPGSAGLSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDE5</accession>
    <name>A0A4Q9QDE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Copper chaperone taha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_804617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDE5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDE5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="8">
        <location>
            <begin position="16"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9097" checksum="D9E768685B55F803" modified="2019-07-31" version="1">MRGSGLTDSGLTAQSEHTYKFNVKMTCSGCSGAVDRVLKKTEGVSSYDISLEKQEVIVKGTIPYDDLHAKIAKTGKEVISGTTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFI2</accession>
    <name>A0A4Q9QFI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_781947</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFI2"/>
    <dbReference type="SMR" id="A0A4Q9QFI2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="14">
        <location>
            <begin position="151"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="355"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU66170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="507" mass="54325" checksum="CC8DDA38E412E1E4" modified="2019-07-31" version="1" fragment="single">LTLSLKSYAAIGPVTDLTVANANISPDGYERAAVLAGGSFPGPLITGRKGDHFQINVVDQLTNHTMLKSTSIHWHGLFQKGTNWADGPAFVNQCPISTGNSFLYDFHVPDQAGTFWYHSHLSTQYCDGLRGAMVVYDPNDPHKNLYDVDNDDTVITLADWYHVASKLGPAVPFGGDSTLINGKGRSTATPTADLAVISVTQGKRYRFRLVSLSCDPNFTFSIDGHALTVIEADAVSTQPLTVDSIQIFAGQRYSFVLNANQSVDSYWIRAQPSLGNVGFDGGLNSAILRYDGAAPTEPSALAVPVSTNPLVETALRPLNSMPVPGKAEVGGVDKAINLAFSFNGTNFFINGATFVPPAVPVLLQIMSGAQSASDLLPSGSVFVLPSNATIELSFPATANAPGAPHPFHLHGHTFAVVRSAGSAEYNYENPIWRDVVSTGSPGDNVTIRFRTDNPGPWFLHCHIDPHLEAGFAVVMAEDTRDVKADNPEPKAWDDLCPTYNALAVDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K2F8</accession>
    <name>A0A4V2K2F8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_590278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K2F8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="8751" checksum="4AC9B7FCCA45C582" modified="2019-07-31" version="1">MAATARLTSPLRPGTQFPTGAPTRIASSMSFSGAMMVSVLAGLYPDGERLGQCAESRLILTGAKWARRVYDAYPGYSGALPKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K479</accession>
    <name>A0A4V2K479_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_905129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K479"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="60079" checksum="3F648A4F52161822" modified="2019-07-31" version="1">MSPPVLNHDILLTVMSVSPTSTATSIMATCRDLYHEGAKIVLQHPISLGGPEEKALSLLRFLQAEDLSRCSYVRAFNLIKIDPMPKSVARILVKILPRMSSLERLMIAPEDMLKSYPDLLPAFAAIQSLKQLVMANVGERSIRLIQALQSQLVSATLYFNSNSSRQNMFMSITSHPVQLLKKSASTLQQLTCGQWVDMLPEPLLTVPNIVYPEMRSLTLAENISPNPIPYIRSFPGLTHLTIESHRTDHLGGAFGDFSCIQRQLNLAMQEPDDIVPSSWHHLEHYTGRLVDHWTFGLTCHIHRLTHEDVPGQRAPSALTDVLQSARPSELVKFHGSPFKDVFTSDFLDALRTEGAAHMKGLIVSIDITAEDREIDVARTLTDFETTIVGLRLHHLQCEVRDVGLSNSEETPNEPRPAPGAVAGHYVTSLPRSDTSVLVSGSPEAQSHACAGSVAEESLCTAERTLVAFDVEAFAHRIISAIPTITGMIISIDTPRQCGGGRRIALLGREEEEIPELRTGGEIVYRDLSMADYNAMRRSQEEGPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6Z3</accession>
    <name>A0A4V2K6Z3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_936654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6Z3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="115" mass="13148" checksum="F67714CC8D5A70D3" modified="2019-07-31" version="1">MIRTLKVGLEQDVKYSALYRLENGKQLVLLVSSSSLRYPLPSFDTLRASTSTLSSFTELTKMMRRWRLRLGKLGYTSPAIAVDLRGPFMRGLEISQVDRYAHLDSRNSQRLPIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K783</accession>
    <name>A0A4V2K783_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_714735</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K783"/>
    <dbReference type="STRING" id="114155.A0A4V2K783"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="559" mass="61763" checksum="83BF3E0B448A1C68" modified="2019-07-31" version="1">MSTELTPAQLATTAEHLLAAKMFSLASCVMLFYDITITFGDEVERIWKQRFTGATVLWFLNRYLSPLGYIVIIVSFQDPNWSKAACQHYVLYPEVLKVFTTTAVGIIFILRLYSIYAKSNTVLYGFTTLLALELAVKIWAFTDGTMLQLPPGFVGCILTGRSAPGDRLIYTWVAELVFDSCVFFATLYRTIQLYRRTVFGEARSLITVVMRDGIMYFAAIFFSNLVTVLIFIFAPNDLKVINASFSTLITSLMVSRLMLNLRGEVLRRGPVMSSHHSATGIVRDNGAQSYQMSSREFSKPEAGWTSFTSSIVGNLGAPVITFEADNSTDYEDLNDDDLDSGNSSKSHDALSPRSPRSPYSASPPSYHPYPPSPVSPHTADPLRHNYDDHYSHSRYHTESSDDTMGWTIVSMTDRIVDPPSALSSPSYPLPLRPSTSPGSSPRTVSRQPSAESSGGSGSSASALTALPPRKARLAGMKSLRRPRTSESEMSDRDVVEMMQTRSLPAPLVVQVTEEVVVEEMAGPSGAEETSPRSPSGRTRRPWLAPPSWKLSRDGHYEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7A6</accession>
    <name>A0A4V2K7A6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_950807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7A6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="930" mass="103065" checksum="8767E2FFA6492B5E" modified="2019-07-31" version="1">MAAEFPLPFPAQPDCPQSEGSASTSEYDPQGASALFYALFQQSDSLHRSHRSPTSLASADAATRSSSWVAPTVSRSISAESSSLAGALHLHNLSFDAAVERQAESSQDAYQPSAAEVPEPGGKTSDEFHSADPTSKKKGGQILADKPLTSLGKPRERIYLACVQCRTRKVRCDGAKPECANCIKRADPVAGHCSYDPAPRRRGKDRTPGSRRLAPLQPKKTRTTRSRVEEEERRKKALATQAAKAAHSETHSALARAQTAHAVQDLSSSWPSYATPSIVPEVQRRTNNAGLTERASATSYFATLPSFPQPHRASSGPVVPQNPTEPTYIHFNPDPIEPRDPVLLYAPLEAFELARRIEEDPDDSQTSVTVWTPPGVRFTRETWWDALLAHYADVPIGRSMTADMRDTTMQVVFADLRFLFQNSLHWFAFVNIPRFFASLWDPYHRQAVQPSLICSALALSTFFQSSDLERGAKGREKALQLVDQAHAMFDASLSSGWIDVGLVQAAWLLAMFEIQAHPRAATSRTRSAFKTLDSLIQSLSLTTLDMADPRTSTFAPGQVPVVTATATLPISINPPPMALDNRAPALAPPAVYHPRQGFVPGYSHAHSQLLSVDDSQWQCGCSSYCLGSNWPQSVELAPAWTCMPMWPDGTSEGEVQKEECRRIVWSTVMLTVSHSTKTTAGTDQEPQHLWIKDPANYALLFPGESLVPMGMNTIPFSKESVWALYMRVLFLWHSALRQRGNLTLSDADRAAYAMGAWLELDNVEACLDRHSCGLQSGFMMQMREVLFNTRMVVSNEFRRYIPEATIVDGSLFYREKAQRWMKYMLGSAQQFSQSFKSPGTQPNSNSRRCFLMYWFMSQIMRGLSLWYADRTLFIALEVAKAFAPCVEFMMMIWPCPGEIIAFGFLCTSGVDMRGKSTRSAQGKRAIGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7J6</accession>
    <name>A0A4V2K7J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_950084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7J6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="10351" checksum="CDFD4E6C9482D6FE" modified="2019-07-31" version="1">MHTFREHKPVPTHNDLMPRAAAPADVFLDVLDTPIPCIRCRMQSPQRCPTRSFSLEYAYERHEVSRRAESTRTRRRQTVSQGTDDIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8F4</accession>
    <name>A0A4V2K8F4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Double-strand break repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_947725</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex (1) mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is (2) required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16 17">Belongs to the MRE11/RAD32 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8F4"/>
    <dbReference type="STRING" id="114155.A0A4V2K8F4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000011">
        <property type="entry name" value="Double-strand break repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003701">
        <property type="entry name" value="Mre11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00583">
        <property type="entry name" value="mre11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000882">
        <property type="entry name" value="DSB_repair_MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9 16 17" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16 17" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 16 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11 16 17" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="10 16 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 16 17" id="KW-0464">Manganese</keyword>
    <keyword evidence="15 16 17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14 16 17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="545"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="545"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="629"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU59768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="712" mass="78478" checksum="FF9A7545FCFD0CFB" modified="2019-07-31" version="1">MSVPSDDEYEGMPPPTIRNAYADDTIKIMLATDNHIGYLERDPIRGQDSIEAFKEILQLAVKHDVDFILLAGDLFHENRPSRDCLYQVMALLREYTLGDRPIQVELLSDPNDGKPASYSFPAINYEDPNLNVAIPVFSIHGNHDDPQGAGPEGALCALDMLSVTGLINYMGKIDLPMNDAEAQDTGIAIRPVLLRKGNTRLGLYGVGNVKDQRMHFELRSNRVRMYMPKDKDSWFNILLLHQNRVAHGPQQSVPEGMFDDSIDLVVWGHEHDCRIIPEPVAGKRYYVTQPGSSVATSLADGEAIEKHVALLKIQGKEFELTPIPLRSVRPFVIDEVDLSEAAEELGFDLTDKIEISKYLKNRVNELINKANEQWDERNARALEEGEPELPRPLPLIRLKVETTGVSEMSNPVRFGQDFIGRIANPRDVLTFHRSKSKGAKGKGKIKADVPELSIDDPDLTVGEKLSKVRVQTLVKEYLAAQELQLLGEAGMSDAIELFVDKDDSHAIQTHVHSALRSLMKGVQASEGEVDADNIDELVEQVREQHEQRYLQKRTEEPAKGKGKAKAAEESDASVDSMMMDVDQGGSDFDRQMSDAPPPPKAKGRAAPKKAAAPAKKAPARGKKAAAPPSDDEDEDEIEDEIVPPKRTNRAAVLSQLTKKAPARKATGTKAAASGSKQTQVTLNFAPAGRTSARAAATRAKRKVAETIELDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8J8</accession>
    <name>A0A4V2K8J8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8J8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5431" checksum="40370454C158BC30" modified="2019-07-31" version="1">MMAPASPATALLRLTLTICPPSFVEFCRAERELWGCHVPSTCAKGVLQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWR0</accession>
    <name>A0A4V6MWR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWR0"/>
    <dbReference type="OMA" id="YALDCIV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24892" checksum="22941B07685EA3E6" modified="2019-07-31" version="1">MSETKQTCTCGQCFEGWLSPRMKELLDYSTELRYGLAKSLLHTQDGVGEDVTSVLPIDYTHIDNSVYYLPLEVRHKIGPSTQSGDAVYRGYIAVFEAIKDLLSEERKDFPTVATVSAKLAELRDSEDASLKPIAVFLDNGGKAEYALDCIVDRAREELTPLGRLYDAETQYIDAVLDGEENHEKCANDLDFGLVREKLGLSVESLGALPDDDEDSRDPVSDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9ME46</accession>
    <name>A0A4Q9ME46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_917656</name>
        <name evidence="10" type="ORF">BD311DRAFT_730276</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143489">
        <property type="protein sequence ID" value="TBU24011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9ME46"/>
    <dbReference type="STRING" id="114155.A0A4Q9ME46"/>
    <dbReference type="OMA" id="DKMWRVV"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU24011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="552" mass="60027" checksum="10CC263FB9619DCD" modified="2019-07-31" version="1">MASYAGDKTSTSSADEGVPKLGKVPASNDAYALDEKRRAALAEIDEAPFSWFHVKVCMVAGVGFFTDAYDIFAINIASTMLGYVYGKGQKLSANQDLGVKVATPVGTLCGQLLFGWLADVVGRKRMYGVELMLIIIATFGQTVSGQAHAANIIGVLCAWRFIMGIGIGGDYPLSAVISSEFATTRTRGRLMTAVFANQGWGQFTAALVAFIIVSAYKGSILHEDPIENAKIDQMWRILIGLGCVPGAIALYFRLTIPETPRFTMDVERNVKQASQDVEQFLTTGSYYVDPDAVVERVQAPKASRRDFVAYFSKWENLKLLIGTSYSWFALDIAFYGLGLNSSVILNAIGFGSPSPTLKGGEKIYTNLKNITIGNMVLSAAGLIPGYWATFLVIDKWGRKPIQLMGFTMLTILFIIMGFGYDKLIATKSGKDAFIFLYCLTNFFQNFGPNTTTFIVPGEAFPTRYRSTAHGISAASGKLGAIVAQVGFGKMVNIGGTSKFVNHLLEIFAFWMLTGIFSTLLIKETKLQTLEELSNENQEGFIEGGPATNSSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MRR0</accession>
    <name>A0A4Q9MRR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TPX2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_54346</name>
        <name evidence="7" type="ORF">BD311DRAFT_251755</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPX2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MRR0"/>
    <dbReference type="STRING" id="114155.A0A4Q9MRR0"/>
    <dbReference type="OrthoDB" id="3242303at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027329">
        <property type="entry name" value="TPX2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06886">
        <property type="entry name" value="TPX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPX2 C-terminal" evidence="6">
        <location>
            <begin position="768"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="473"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="781"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="663"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU29768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="848" mass="89803" checksum="FEF2E282C8094987" modified="2019-07-31" version="1">MGELSLRHIPDLSDASGIGEFSDSSFQIPAAARHADDLLLADDTMDFFSNENHTLSTPAPSKPPVQPPLTLAELTPRSKPVRAAATRSSLRPRPGVATPYRANIAQGLSAALSEDLSPFRKHDPSFEIPPPQTHDDDDLLMADDGHQFLSEEQSSLDATPPRAPGSTTGPSTGVTPSDAPPYAVLVEPLPSVQNIPTELVPRSPQSIADVYIVDPASLATVSGIPNMPESIPAVKIEDNPHDPSKKGKGKALSRVNATVRQKMAPGGDKAKRKRVTPAAAISKPAKLKPLTASLAPRLSASGKKTAPTLRRRPLQGGPSYTHTIGSSGSVAATNGHANPHAAPADVKPFRSGGLADTLMSYGQKLMSTTQSSNDALAEHCEDAADTVEDGIPPVPETTVSATSALSPNADDGPVAHDMAHPASEQQHARAVLDRDYLTLSQLSPRKAEAAIASSTTLASLNTNEALVPVLDQPIPPAASSERQESSPSPMRTSIKRAASPADELSVHQRKRGKTVPNDMEPSSGDLRSRRPALQPSRSKNVPAGAPLGSGPTSRTRRVVSGTAKSTTGGVASADRATQPTETTCKPGLKSSRSQTVPGGEGLANPTVQTTARSMAGTTLKKSNRNAAPSSSNNGSRSRNFTVPQREGVPDGEERMTDGLESGRLTSASVDRPSTNLPPAKTTKSQEFTFTTSTRMRTRSRTAAEQTDKSTSHSSGGSTSTSVNGNSHSQSSLKGSRAPIPDFKSLHAMHESVLAQRRAEVHPTVPVGFAFATDTRAAEREKFEEARRARERELERQAEERRRQRELEEEAEIRELRRRAVPRANEVPEWYAFAPKKAKPADAAGGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MXW0</accession>
    <name>A0A4Q9MXW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_914677</name>
        <name evidence="12" type="ORF">BD311DRAFT_752058</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MXW0"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="105"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="204"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="300" mass="32543" checksum="9D60C35FF4D0A9F5" modified="2019-07-31" version="1">MSKTVKDLTAGTAGGIAQVLVGQPFDIVKVRMQTATAGTYKGMVHCAGGILKNEGPLAFYKGTLTPLLGIGVCVSIQFGALEWTKRLFAQQNLRSGRGGPDGMMLSSGQLFFAGSFAGLANGVVSGPVEHIRIRLQTQSATNPVYAGPFDAMKKIWSQYGIAGIYKGQVVTLWREATGYGIYFWAYEKLMQREMQRKGIRRDQVNPANAVLFGAAAGYALWAVIYPIDMIKSRMQTDGFSAADGQKYKSTLDCVRTVWRTEGLPAFTRGLTPTLIRSPFANGATFLGFELASRALNSLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N5G0</accession>
    <name>A0A4Q9N5G0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_919506</name>
        <name evidence="3" type="ORF">BD311DRAFT_746295</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34512.1"/>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N5G0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU34512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="99" mass="11474" checksum="296AEFE5A3438AD1" modified="2019-07-31" version="1">MIFLPICYSYLLSLHIPYTLFHALHHTLIYTLHICIAILTRIHRICIAIICRVFSSTLSPLGRLLNTHLSLLPSAMRLHSRLNEDLEQLREQLKAKEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N6V5</accession>
    <name>A0A4Q9N6V5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_950332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N6V5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7062" checksum="6DB1D85FA1F7C5BA" modified="2019-07-31" version="1">MDPDNEKVRIRRDYAKRSAASQPPPRHSLLTSPQSLSRTRSSSSSILLSASALSASSSVHPPPPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N7H2</accession>
    <name>A0A4Q9N7H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_940726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145260">
        <property type="protein sequence ID" value="TBU52246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N7H2"/>
    <dbReference type="STRING" id="114155.A0A4Q9N7H2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="123"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="454" mass="50462" checksum="D4BEE092C84354D1" modified="2019-07-31" version="1">MKLTVYNETDEDLSFAFLKPGSTTYEASLSIAPHTSATSAVRSTSTTVRVNAQVSEKSDAESVSIPSGSFTTFPLKLGAKWKSVRIPADSPWRMYRSKISKGHYRLSVFPRRNLASFLSEMPDSLPLSSLLLPGTHDTMAFYGWPISQCQSLSTPLNVQLHSGIRVLDVRLSVIDGRLLAYHGIYPQRSSFQDILRAVHDFLASPLSSRETIVMSIKQEDFTRTPLPYFSQCVHDEIMGGPGGRDMWFLENRIPRLGEVRGKVVMLSRFGGDGTGWENGLEGLGIHPTAWPDSERNGFTWTLKGTLVRTHDWYSIPSFLSIPEKAQLSTEILVLPPGEQPFPILNISFFSASSVPLAFPPTIAKGFGWPNWGFGVEGVNGRVGRWLLDKLSGDQVHNRRTEKGEPLNLAGLGGGDVRIRGWTLMDFYREPEDGVVPLLVECNFRGRNKGEEGWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBV5</accession>
    <name>A0A4Q9NBV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_916974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBV5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NBV5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="316" mass="34872" checksum="427EB0FC735A9701" modified="2019-07-31" version="1">MAAHNSVAFPSSRLVSRGSFESASATSLYNPHFQAATEVCELFYGASPPAWQAVERYYDPNATYENPFLTATSKDTIGDVHALSRCLAQLDVPKPGAILRILFRLSPDHRWSDSWFRGLSMWNEVNEVSECESFDGHKRMVVEHTLHIVVLPGLHWHPRHAPPDYSDAGGAVVPRSDSTVSLRDHTTTPTPSAIVRHPKSSFWPPSPFHLVLPIITRLSFNEAGKITHHRDFWDVKDLLGLLPGMTLIQWVTGRLAAQGIRSVVRVGRALFRSPPQDEEAAMGADGRRRSDSYGGPPPAKSARSNIHGTGFTIAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NC64</accession>
    <name>A0A4Q9NC64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_440037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NC64"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="173" mass="19418" checksum="C23FCF030469FD6D" modified="2019-07-31" version="1">MLPVPGAHPLTVIEAPYFLRSVCSDGLPASSGTLRLGPSHSVRMRRRTSWLCGTWVPWLCLAHGQGTHDQPIQNASNRCLRDVRRITLAPYLWVDCRPIKCLRNVRSTSPSGSGSLSHAAAGRFRAQVHSSQFLRTSYGIRRRHAVSAYNFDSHRIPLRCPTPNYPTTRRGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NG34</accession>
    <name>A0A4Q9NG34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catenin-beta-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_964343</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NG34"/>
    <dbReference type="STRING" id="114155.A0A4Q9NG34"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:001136">
        <property type="entry name" value="Beta-catenin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01156">
        <property type="entry name" value="DUF1716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="506"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="627" mass="70540" checksum="6DA43058F66F6074" modified="2019-07-31" version="1">MDIDKLFKVPKLPASSNKRRLPDNPTPEMLKRMRIDEEGSSVSTVSPPNGTASRDKGKNTATVEEEEGEDRMDFAPGGDADYFAEEDDEGRFFGGGLTNEQKDILNIFDQAGGDDVREDLDEMTITGVRRLLTRFERAANKNQDHRSKYPDDPTKFIDSEADLDLATKALLPLAQSPVLAYPEIVRSGAIERLIGLLSHENVDIVIDVVEVIHEFTDEDVGNEQDDEEEEEGSREDALKQLIESLLANSILELLVDNLSRFNEAEESDRQGIFHVLGIFENILGFNPELSTQLVSKTKILSWVMTRIESSRHDENRGYAAEILSILLQNNRPNRLELGKLNGVESILKILSRYRKKDPVDADETEFMENVFDCLCSALGEAEIKQQFLDNEGVDLMVLMLKDKMQARSRAIKVLDYAMSGPAGTAACETFVDALGLKTLFSSFMGKANKKQKANAGHAASEDTAHTLGIVSSLLSNLAWDSPARIRLLVKFVENSYEKPEKLLEIRDSAQARLNATDKEIADEKKRMEEDGEEVKEMEDLFYLRRLDGGLFTLQTVDYILAWIVMEDDGVREHVRKLLDRKNQSLKDIVKTLQIYHDNVDEDDTTNTGDAPSQREILRNLIVFLDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMP1</accession>
    <name>A0A4Q9NMP1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein DUF92-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_829094</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145201">
        <property type="protein sequence ID" value="TBU53935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMP1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="55" mass="5552" checksum="3641E35E46F5F2A4" modified="2019-07-31" version="1" fragment="single">HFACCLGDTLASELGILSRSRPILISTLKPVPPETNGGLSVVGTLASVGRCSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNB3</accession>
    <name>A0A4Q9NNB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Armadillo-type protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_931723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNB3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNB3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="760"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="677"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="874" mass="92925" checksum="C7D543D8056D4AC3" modified="2019-07-31" version="1">MDYLRTLGSAAVSTLVQKSGLNLPFSLGPKVASFENRTVWSLYDGTKRDDSSPVSVFEFEANTPAKKNLLPLAKNALRKLRTIRHPDVLKFMEVVETDATIHIMTERVRPLGPAITEWQSKSAQEREAWLIWGLHRVSVALTFLNDSASSTHGNVRVDSIFISASGEWKLGGFDVLSNPKDDAAVLYSLGGMLPDASMYSPPEVKKGGYSSLKELPISAADAYGLGLLIHFAFNPNQPVPATAQPPHPPPTAASRGAIPISIFPSYKKLLNPNPKARLSPAHFLNLGMSQTAGEGSGFFATNRLVIVCAGLDNFNLASESEKATLLRSLKESASSFPSEFASYKVLPALVSALEFGGASAASIVPLVLQFGKNVPPEDYSSVILSHLVKLYASPDRGIRMVLLEHLPEYADKLDKKTVSDKIWPNLQTGFGDTVAIIREATIKSIILLSDKFNERIMNNDLLRHLARMQADPEASIRTNTCILIGRLGPSLGYNTKRKVLVPAFARALKDPFVHARVAGLMAFMATIDCFDIEDVASKVIPNMSFTLVDKEKLVRDQAFKAMELFVKKLEEHAATMPETVPTIENEMPQVQINGSSPNALVNSAAGAAGALAGWAISSLGKQLASGTLQSSVASTIGTSIDRPTSAPAANVGSAPNPSSTSTLSGFRGGPVGMPLTPTLSSVTGPTRALTSASKGKGMQLGATKVPASVSSASDWAEEAAAELDASTSTATNPWGNDDLMDVNADEDDWSAFETAPLATASEPTDFGFGNVRSPDPWSAPAPAAPPPKPLVAPQPRLSTAPRMVSPLTSPRPASAARSITPSDSGKADAASPAGPSAPSTAGMSKEEKAAEMARRKEERKQRIAALKEQKKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NP30</accession>
    <name>A0A4Q9NP30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_934252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NP30"/>
    <dbReference type="STRING" id="114155.A0A4Q9NP30"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="955" mass="101087" checksum="D3FDD5087BFB0514" modified="2019-07-31" version="1">MSNSCENYGTPNGTACACPPGFGGSTCAQPACGGTIFQGSGRSLANGSPFANLTSSGCSCEDGWTGTGCNVCQTAKACQSGFASVAGTSGSLTGASTGQNNTIVCNDVPRVYAAGEMSCDVQNPTLQSLFPGSSTLTVLRNLNSSFTPLPNTTAFGPSGSVYAQLFYEGVEQFFCAADTCAQDLGTGDGSANWNCQNLKCTCIPNTAFCGAVQLTNLTSIIDTLSGTLGISCDAPSADNNTANCAFKQDTIQQVFGSAGLTLSGCAFGECIAQNVIDTLSGNTNASDGASSGGSSLSGGVIAGLAVVGGLIGIALLLLSLGWLSQRRARKSTSGLRSSGGVIVEWTDISYFVPQPTSGFSLRRRRRAGLDHQKVVLDNVSGRVVPGEMMAILGPSGAGKTTLIEILAQKHKSGEVLGSVSFPGTGSSQARVGFVPQQDILPPMLTVHEALLFAARLRLPEGVPDSEKQARVDDILDRLGISHIRNVRIGDGEKRGISGGEMRRVSIGLELVAKPDVLLLDEPTSGLDSVSAAKVAKVLHALAHDPENPTAVIASIHQPSSQLYHSFDQILLLSQGRALYSGPGRSAPAQHFSAQGVAYKEGYNVADYLLDIASDPPVGLFQLSNATTKSELPDVGTSGSSDEVEKGLVGGAVNVNGVASQRKPKRRPWFAGTPYTATFLTQLEVLSGREWKILRRDKTLFFLHVAVASVLGVFCGGLYFNTGITIAGFQSRVGCLFFLGALIAFSSLSALYNVVEIRPLFLRERSGAYYSPTAWLLSRFVFDVVPLRIIPTIIVSTITYWMAGLADDAAHFFKFLFILVLYTLAMTLFNFLLACLFRNGGIAILISALTALYQMTYAGFFVHLNDIPPVLRWLQWLCPLKYNLEALSVNEVGSGLMIEDSLEGVPVNVSASLIMQTLFGFGENNYYRDVLVLFAFIAGFGLGVVFVVWAKVRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR33</accession>
    <name>A0A4Q9NR33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_992714</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145214">
        <property type="protein sequence ID" value="TBU53448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR33"/>
    <dbReference type="STRING" id="114155.A0A4Q9NR33"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="5">
        <location>
            <begin position="1"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="836" mass="96147" checksum="3284B67705A10ADF" modified="2019-07-31" version="1" fragment="single">RDRPEEREIIEHPTSCYVIGRSGTGKTLTMMYKIVAIEHGWASSYTWGLTKPRQLFVTRSRMLAGQVHRTVNEVLESFRLAEMTQAELAELRTRRDQPEELRRPVPKKWSQLDDDHFPLFLSFDQVIHRRFEKCTISEGFWNMRFDEGSFVSGKRFISTYWSRFPQRLTHGLDPSSVFGEIMGVLQGSEEAHNTARGYLSREAYLGSSERAYSTFATERERIYNIFEAYLKLKRRRQEYDDAERSRTQLNITRTHNLLVLMVKEKLPGPPVQFLYNDEVQDNLMIDMLFMRSLSNNSNGIFWAGDTAQTITLGSSFKFSELTSLMYRVERREPNRLHIPPHTFNLTVNRRSHMGIINAAQTVVDLLTTLWSESTDKLSRDKGHKRGPKPIFIRGSTELFKLLGHRENLGVSLELGSEQCASCTIVRDEVSLDALFSRGVLGGVTLTVEQSKGLEFNDVFLWNFFGSSESSMREWAVYRNVCREAGIFHTFLGLVVEIIRSQLKCLYVAITRARNHLFIIEETVISHPMLNLWRSKDQLDIASNLESWILPVSKSLPEDWAKRGRILMDKQNYEQAKYCFQRAGLPRETNIAQAYHLRESAVTAEQFVEAAQLFESCAAKTLDVADRKELLLASATCFSRARDNLRSAELYHAALEYTKCIVQYCKATSWQKALDVICQHRDDVELRAMQNVLLHFFDLGQYSRIAEVFADTEELILFMKIHGMKPHLAAYLELLGRYQEAAEIHLGLSHIPQAIALFFRDPDPNSAAQGTTRLLDELWQVSTLGQSVNEVSKTSNVPIQTLVNLAKQRQALFGIQYKNHQIHEDEVTCQLNVHELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSL7</accession>
    <name>A0A4Q9NSL7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_920686</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSL7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033910" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="58"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="570" mass="61514" checksum="B22F1CAD348344E8" modified="2019-07-31" version="1" fragment="single">MRTHAVYLFAFQAICSLGASPTTGSSTLSSIPSIAPAAASVLPDPTSPTAPAIPSGAPTIQLDEGTFFGVSNGVTNSFLGIPFAQPPVGDLRFAPPQPNSPYKGVHNATYWGTQCLNTISITGTVLPSWATDEMKRYFAIFSTLAPSTFGEDCLNLNVIAPANIKAGQKLPIVAYIFFSGFDFSGSSNVDGRIMVNRSIEIGEPVIWVSMNYRLGSYGFLPGRQIREAGSGNMGLRDQREALRWIQKYIPAFGGDPSRVTLLGLSSGAASATLHTVANGGDSEGLFKGSWGESGALQHLGWIDSPLAQGIYDEFTEKLNCSDATDTLACLRQVPVENIKNVSASSADQFWLITADGDFIQEPPQQALVKGKLAPVAIVNGIAEDEGTIATLTFPDGANDTLLLNFIKQAFPNMTDSQAQVVLDLYPDDPSEGAPYGTGSQYELAPMFKRIASIAGDIDFDSNHRLLGSFVANRQDFWSYYYTRNFVYGFGSTHGGEIPNMYGGGDMADLLIHFANTFDPNGPKPKTYWPKYRLAAPIMLLFSGNDTLSYKDDTYRSDQIDYLNHLNLAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXK6</accession>
    <name>A0A4Q9NXK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-hydroxybenzoate polyprenyltransferase, mitochondrial</fullName>
            <shortName evidence="8">4-HB polyprenyltransferase</shortName>
            <ecNumber evidence="8">2.5.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Para-hydroxybenzoate--polyprenyltransferase</fullName>
            <shortName evidence="8">PHB:PPT</shortName>
            <shortName evidence="8">PHB:polyprenyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_851320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an all-trans-polyprenyl diphosphate + 4-hydroxybenzoate = a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:44504"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:9564"/>
            <dbReference type="ChEBI" id="CHEBI:17879"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58914"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="2.5.1.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.39" evidence="8"/>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXK6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXK6"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000003">
        <property type="entry name" value="4-hydroxybenzoate polyprenyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01635">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006370">
        <property type="entry name" value="HB_polyprenyltransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01474">
        <property type="entry name" value="ubiA_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="373" mass="40719" checksum="F7755F9677C11C9A" modified="2019-07-31" version="1">MGSTLGLRVCLGHSAHSLNSCTISSITRRSVHILRYCGRPKTPRNFTLQQSLLTEVIRRSGSLSSAPAPPTTWVDRLPKPVRPYLYLTRIDKPIGTLLLYYPCTWSITMAAYALESPLTTPLTYLSLFGLGALVMRGAGCTINDMWDRKLDKGVERTKTRPLAAGEITPTQAFAFLGLQLTAGLGVLTQLNWYSILLGASSLSVVTIYPFMKRVTHWPQAVLGLAFNWGALLGWSAVAGVTNWSVCLPLYAGGICWTLVYDTVYAHQDKKDDVKMGIRSTALLFGERTRPVLAALSGSSMSLITYAGYLNGQGPLFYGGVALAAAQLARVVWRTNFDDRPSCWKGFVGCGWSGFWIWMGALADYATLLLNASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2H2</accession>
    <name>A0A4Q9P2H2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL11m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_926428</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2H2"/>
    <dbReference type="STRING" id="114155.A0A4Q9P2H2"/>
    <dbReference type="Proteomes" id="UP000292082">
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        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL11_bac-typ"/>
    </dbReference>
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        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
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        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0687">Ribonucleoprotein</keyword>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="148" mass="15785" checksum="A9D53E3D1A583758" modified="2019-07-31" version="1">MSKAALNAKAQFIRLLIPAGKAAPSPPVGPALGARGVKSMDFCKEFNARTAHVEPGIPIPTRILVQPDRSFSFITKTPPTAYFLKKAAGIEKGTGRPGHDIVGTVSLKHVYEIAKIKQSDAHLKHLSLEKISKSVIGTARTIGIQVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4A8</accession>
    <name>A0A4Q9P4A8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_921703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        <property type="project" value="GOC"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:trans-Golgi network"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PQ-loop repeat-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
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        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="242" mass="27261" checksum="12B2F30FFC7620D4" modified="2019-07-31" version="1">MTTWVSTLASVGMAVGPPLVYADQAYSIVRKQDATGFSRDVCAILLLANITRCFFWLGNRFETALLVQSFLMIIAQLALLYICIRFRPRLSPESLGASTRPFSFWQWPTYTQHLEFLAAFILCESILFLILGRSEVFVSILGFVALGLESTLPIPQLISNYKQRSLYGFRMSTLIGWFGGDSFKTVYFFLQGSPLQFKVCAIFQLSIDCAIVLQRIWYGNAPPATALMEDEDIEQALALDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5Y7</accession>
    <name>A0A4Q9P5Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_944257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9P5Y7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="21410" checksum="9336A9357F2774DD" modified="2019-07-31" version="1">MPPLLRYEDLTFKRVGEAIDLVRQLFEGLLFLHRHYIAHRDYTSRHIAMLAECPWPQYYITLSLASHAYDPNEELLAFPYVGGDMSVPEYRQGLLGRHDPFAIDVYCLGNLIKRDFIQVYSNLDFMSDLVANMVHDDPGKRPPMDEVMEEFEKAVGGLTIKTMRKRLRRRRSRLINLFLKTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P620</accession>
    <name>A0A4Q9P620_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_866744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P620"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16970" checksum="56F9887215954661" modified="2019-07-31" version="1">MMSVMPPSVHLQVHLDANRPTKDVEFNELGNLNEAVEPFAQLIKKSGHSVRLHCTIPTGFHSSPTCADLHDLHDLRTRSLMFVHNLVESLRASGIPASYRLQPANCSMCLICALPSGLDASKVRAAAFAAVQNAKLDLKEKALLADLQDGYALVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7I3</accession>
    <name>A0A4Q9P7I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7I3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="231" mass="25495" checksum="0E5DA71AD47E62A0" modified="2019-07-31" version="1">MAGPRIPTAKCNSAGDSTFRRTLLGELRFSKDPVDRGSYTVQARYRQTPAGSNTPGWIQTLYSTAARTLLNHKTPKGRMRTWYVHGLRSLSGTRHAVARLRRKRPNPPSPRYLSIHTYHGSTGAAGQQRGVCAVRHPACVSHGTDVCARVHVPCLAVSQPHTVYGRARRQSCPYYPGAPSPEPASPRPRRRADVKYGRNHTPRARRSRGTPLPQLLQTAAQRVVAVSLPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7U4</accession>
    <name>A0A4Q9P7U4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_912499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7U4"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7U4"/>
    <dbReference type="OMA" id="TIRTWPL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044715">
        <property type="entry name" value="WDR86-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44489:SF11">
        <property type="entry name" value="WD REPEAT DOMAIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="405" mass="44531" checksum="A1164F1E5582BE8F" modified="2019-07-31" version="1">MQPADKSHFLRSEAELRLEQSRKDKAERIKDLGSPIEITGKALAVHIRDNVAWIAENTTVVRKLDLETGKTLRLFRGHAAPVTSLAFVDRVPGSGKGDLLITSSWDKTIKVWDVETKQIISSTDGHSDFVKAIHAIPSLGLLVSSGSDKVVRLWDLSSVADGRPLRTVGILTGHTRPVESLVARVLSEKAAVLYTADTMGIIRVWNIAKEDNLDSQWKIVPTGELKHHRTGVNEMIVGDGHLWTASTDETVQIVPDPTLPPTPGAKPIPPIQHATAVKAILPLPLTVLGEPYLLTGTGAVIRVYDISSLEEPELIAETDGHWHDVTALRLWIRKSEVEGQPGKVRVEPWIVSASLDGTLRRWRLSELLHPPPPKVPAEEVKVADVPVNILDADEERELAELMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8X3</accession>
    <name>A0A4Q9P8X3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_915101</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8X3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="479" mass="51637" checksum="8A00C02556E7406D" modified="2019-07-31" version="1">MGKVERVVFLSLVLDLFAFTIPLPLFPRIIEWYTKRESSDLNGFLSRTLSLVSGFRSLLYKPSSNPQKWDIVLLGGLMGSVFSALQWFISPYIGSLSDKYGRKRVLLITMIGNLLSAIVWLQSTSFASYLLSRVIGGLSEGNVQLAIAILSDVTTPETRAKALAHVGIAFAICFCIGPPIGAYFASRPLPRSITASGFELNVYAGPAALTLVLLTLETIFLVFALPETRGKAAQKPVVNGSAKAAVNGKTNGTARTSRQATVAERLKMLKTLQRLHFLFLGIFSGVEFTLTFLTFDLFDWNNKQNGTLIGSIGIISAILQGGYVRRAMSRVGEGKMALRGISSCALGLIFLTILPHFVESRPTIAVRLLQAAAVCMAMTSATVVNSLTAFASLQTDDVTVDSDTGKAMKEHPDLAKGKALGKFRSSGQLGRAIGPLLACASYWTFGPSLTYAVSAVAMYALVGYMRRVTRGTTVTAKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA12</accession>
    <name>A0A4Q9PA12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Disintegrin and metalloproteinase domain-containing protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_890940</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable zinc protease.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML145347">
        <property type="protein sequence ID" value="TBU51278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA12"/>
    <dbReference type="STRING" id="114155.A0A4Q9PA12"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006509">
        <property type="term" value="P:membrane protein ectodomain proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04271">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.70.10:FF:000003">
        <property type="entry name" value="Disintegrin and metalloproteinase domain-containing protein 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1620.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.70.10">
        <property type="entry name" value="Disintegrin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051489">
        <property type="entry name" value="ADAM_Metalloproteinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041645">
        <property type="entry name" value="ADAMTS_CR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001762">
        <property type="entry name" value="Disintegrin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036436">
        <property type="entry name" value="Disintegrin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001590">
        <property type="entry name" value="Peptidase_M12B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034028">
        <property type="entry name" value="ZnMc_ADAM_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702">
        <property type="entry name" value="ADAM10/ADAM17 METALLOPEPTIDASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45702:SF2">
        <property type="entry name" value="KUZBANIAN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17771">
        <property type="entry name" value="ADAMTS_CR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00200">
        <property type="entry name" value="Disintegrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13574">
        <property type="entry name" value="Reprolysin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00050">
        <property type="entry name" value="DISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57552">
        <property type="entry name" value="Blood coagulation inhibitor (disintegrin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50215">
        <property type="entry name" value="ADAM_MEPRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50214">
        <property type="entry name" value="DISINTEGRIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020684288" description="Disintegrin and metalloproteinase domain-containing protein B" evidence="13">
        <location>
            <begin position="24"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="762"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12B" evidence="15">
        <location>
            <begin position="325"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Disintegrin" evidence="14">
        <location>
            <begin position="574"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="791"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="844"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="865"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="476"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00056552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU51278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="922" mass="97952" checksum="3FB2541154DC56D3" modified="2019-07-31" version="1">MYSHHHICWLLVVLLASFHSASALSAPARPLRRLSHPSTLSIDILPRRQSPPILGKRSLPIDSPVLHHTDSFRLTLTAFDETFYIHLRPNDHLIHPAARVNYYKTGPDGQSVLTRTEPILRESVKAYWGEVIPAHVSPDRLREDTAGVIPRPSGIYELGWARITVYDQGDADAGRPPVFEGAFSVNGVTHHVQTKANYLRNKHALDPHIELDDAHPDANLVIWRDSDVMSKHEHERILGLDVSSPKAHGHGETCGHDRMDFNTDPLQNEAIRKVPPPPYTPWYDAFGFLHSATNFSKRDDVAGGGMGIDFSGYIGQTAGCPTSQKIVYMGVAADCEYTSKYGSTGNATRAIITNWNTASALYKTTFQVSLGIVELQVHEPECPSTATSDAPWNVACSESVTLNDRLSIFSGWRGQKGNDGAGLWHLMSGCPTGSEVGIAWLATLCQQTSSGSSPSIVSGTAVSTSGRTEWQVIAHEIGHNFGAIHDCADGCSCSNGCETDSVNCCPLSTTTCDANSQYIMSPVAETGEMQFSPCSIGNICSLMSGAAGGHTNTTCLIDPNAMASLTTSKPVITLQMCGNGIVESGEDCDPGLGSNSTCCDASTCKFKKGAVCDPDSSQCCTDSCTFAPSTQVCRPAKDATCDTAEMCTGSSATCPPDVFASNGKSCGSNGLACASGQCTSLSQQCQLVGASMGLSKACPSNDDKSCQVSCQDPNNSNQCVVLQSALIDGSPCGYGGTCISGNCKPGSWQNFFKSWYTHNLQISIPVTVIVGLIVLLILYAIARCIMRSRRSKPARTAQRIPSYPGPPPMNFAPSAMVRQNSSSTPMYGPNVPVSVAAAGGGQQRPGRTSHSSRSSAGSGGPAGPAPARRTSGGSNSVVSGGARQSRQGSGHYAPAFPIEPIRNSRMDWVDDTVYNGPAHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBM9</accession>
    <name>A0A4Q9PBM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145329">
        <property type="protein sequence ID" value="TBU51395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBM9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="132" mass="14923" checksum="E8BF2C7502D88F22" modified="2019-07-31" version="1">MRARQSGGQEKGTEYAAPCTLHSPLHPAITHASSARSCAWRIRHSYQIYVLQVETRSAICPVSPPEEPNDVPRQMRLPKAHSPEQLQPHTADDGQYFWDVDGVGERSPLCRPLLILGLTFGRLAEKRTKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC31</accession>
    <name>A0A4Q9PC31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_770282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145265">
        <property type="protein sequence ID" value="TBU52118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC31"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="2"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7116" checksum="1A6F168F663374BD" modified="2019-07-31" version="1" fragment="single">ICSAAVFFFDSMITTAEEIRCFWGRKITGAAILFWLNKYMTALCLIWDLATGLDMSEKVCTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCC2</accession>
    <name>A0A4Q9PCC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_804224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCC2"/>
    <dbReference type="OMA" id="THYKYFA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11957" checksum="75ABB27605CCFFEB" modified="2019-07-31" version="1">MAIRHRRTHKSQPSWFDKVFPPNRSKEARPGPPSPAAGYALIAASVAFLLVGSYAVFFSALVPVTGVWLLDVMARDTHYKYLVIILISSGTGFVIANWVGWQYYRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCU4</accession>
    <name>A0A4Q9PCU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_910000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145244">
        <property type="protein sequence ID" value="TBU52609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCU4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="295" mass="32595" checksum="182E0F7455AFE519" modified="2019-07-31" version="1">MSVSEVPDRQSRCPAKDGPDSGPELAFEFGLHNTLPIRQGDDYIVLIVDWRAENETLKINQTNRRHFDQSEVFSTSKKDKRSTDAEDIDRRADAKVPIELSVKAMAEQVKAGKVRYLGLSEVSADTLRPVQVEYSPFTTEIEDEKIGLLKAARELGVRIVAYGALGRGLLTGKYTDPDQFPPTDFRRTIPRFSKENFPSILKIAEGLKKVGEKHGASSGQVALAWVLAQGEDIIPIVGTTKFDNLKENLGAYDVKLSPGDVAEVRRLADGASVPGDRYPARLFHTLFADTPALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDA0</accession>
    <name>A0A4Q9PDA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 18">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_912966</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. Negatively regulates the biosynthesis of acetyl-CoA from pyruvate in the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 19">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 18"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDA0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDA0"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 18 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="24"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="63"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <begin position="372"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU66207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="417" mass="44839" checksum="CB6C7E51180282F3" modified="2019-07-31" version="1">MSISNKLSITDLDLKGKRVLIRVDFNVPMADGKVTNPARIVAALPTIQYAIDNGASKVILMSHLGRPDGKVNPKYSLEPVSHELEKHLKKSVIFVNESVGPDVEKAVADAPEGSVILLENLRFHIEEEGSSKDKDGKKTKADPAKVTEFREGLTRLGDVYVNDAFGTAHRAHSSMVGVKLSQRAAGFLMKKELDYFAKALEHPERPFLAILGGAKVSDKIQLIENMLDKVDSLIVGGGMVYTFKKTLENMKIGNSLFDEPGSQKVASLVEKAKQRNVTIVFPVDHVIADKFDKDAKTGLVSDEEGIPDGWLALDAGPKSRELFRETVLKAKTILWNGPPGVFEFPAFAAGSKALLDATVEAAQNGATVIVGGGDTATVVAKYDAEDKLSHVSTGGGASLELLEGKTLPGVAELSEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDF6</accession>
    <name>A0A4Q9PDF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_781882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDF6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="200" mass="22195" checksum="FB89DB5F7736313E" modified="2019-07-31" version="1" fragment="single">DHRSDSVVVVSPCTQVGTSVRWAAEFKSPWIAEQILAKFQREGWQQGSDNPLQFSRPDQRMPLEAPSSKPLALGGVMGGVNRSQRLTKMSFEPEPPAFVVRSPGSPEASKPSASSESSQVLPPWPQVRTTMQFDMPHLPNTFTHDTYYTPDLAFYCPALFDALIISRGVRLTTAHLWLLRMTPTSGHVGASGYIMIRRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDQ2</accession>
    <name>A0A4Q9PDQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_780693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145334">
        <property type="protein sequence ID" value="TBU51367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDQ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="652" mass="71556" checksum="6E756EC37657F33B" modified="2019-07-31" version="1" fragment="single">RGHGRGRGRGRGRGRGASTLTSPMAPENDVEAMERGPETSSEPDSETTQEHSHAYNTRPTNTERNPALYPGLNWQHDKAKIERKAAEAQAKAADAAKRKADRLAQQEREQLGSRRLAALEDARYVAEQEEEAYMVRTTAVGYNLRRAGASSAPPAQSADEPMEVDHLNGGNGSEDEDFFMGDADEAVESEEEGAQSRQAQQKAQRRSQVLLNILKSRTVDNGSQASVKTSAKRPPEEVEAAKRPPKKPAVSALSDDWISRSHPISRSPSIALPPNSRSSSISRPSSCTTQHGSRPSNTGSPTPEAWKSMLQAKIGLPGPPNAPNDADHGSKAPRGTIVLAEEEIGGLQDEDNAFARPSTKAPVASTQNMLNNLNFHDETSLSMKAKRTAKKDMPEEQSLSVDNLPQWIKPVWPQLSASLCAFYGAEKNPWVLDRHEQDPAHFDNVFKVLVDTLCPEKQYIVDSGDQVYKVARQAVYNWRRAFANAAHSAVKQALKQRAGTREQVAAWAKQANAYGGEGHWEKPDTEEGGTPTGALQSKYMLQTLAVHPRRTEHSIFTNLGLPIGALTLACTVVDVAFRHYYTGVEAAPPGLKRFEYDTVGEIMDDWYDSTVRPLAEKKSHRFEALMERARVWGRAASSAPSLESRLVVVQPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEW8</accession>
    <name>A0A4Q9PEW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21684" checksum="01AEC870745B4F64" modified="2019-07-31" version="1">MFRLKPWIALLITDHELCDTKSPASVLSFDALETVTIKVPEPIDHSDHDKLQRQILPLISPFTKPGLVFSLTFERCSVHSDQGYCVEPLSRGDIFESVRTSGNMLHTLQETSKCSHLELVLEDLPDVPYKDRLIPLEKSQGDPVYFRTPDRSEISLLECFQDRCDTLIGGVNPVYAYGFPAKIYLDFPSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF34</accession>
    <name>A0A4Q9PF34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum vesicle transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_991475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF34"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF34"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14438" checksum="42482D4094DE3121" modified="2019-07-31" version="1">METDMDMVTGLLCPECDFSEGARRDASRAPGCFAGRSRGFFDTLLRHTKSSFKPTYNYQPDGSACRIYGTITAKRVTANLHVTTLGHGYASHEHVDHKFMNLLHVITEFSFGPDFLTQSEVTSCVLARIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFM3</accession>
    <name>A0A4Q9PFM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40-repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_952986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145274">
        <property type="protein sequence ID" value="TBU51967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFM3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFM3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37070" checksum="F135884F604A3052" modified="2019-07-31" version="1">MPPEYSLLQLAARHAVAEGSDKDKAINLYAISVQVKTLAGLSLSDSPQHIDKFPTNFHYSAKAGILVFSGYVHNDGDLKKAKENDEAWENRENRGDTAFVYDETFERHWDTWGADGKWALGSDFVNLLKNTNHHAPVEPFGGTDDFDVSDSHVIYTAKDPQHPKAWHNKQNASPSIWIWKHGATHSPVFNTAGNKAAWTQLDRDCHESDRAKLVIYDLKKDVQYTLAGHWDRSVGSIAFAHDDKTVFFTANEHARGEIFSLPVPETPSSSSSDPSFSAEFATVGWPARVHALVAHGKPEVEQITRFAASALKSKTLDDGSDFWFEGAEGKKVHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGB1</accession>
    <name>A0A4Q9PGB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145269">
        <property type="protein sequence ID" value="TBU52061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGB1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11149" checksum="D7A50C2A7DD5D298" modified="2019-07-31" version="1">MRRNLKPSGARYRDGTACSPWTRAPDDADIAVLVLVVLLRHQGIRARGNTILRLIWVRAYSLLIPSIGAALWPEISATHIAPTSPSENLFRAGTCHNNGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH76</accession>
    <name>A0A4Q9PH76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_861174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH76"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40084" checksum="5A9BEA733FF8E9EA" modified="2019-07-31" version="1">MPSPVASEYTTTMAPEVAPVKLNTFALEIIQYFSSDAIRTTPQYTLSSLLFGALTTMFAASVFLLIRQRSLSQLSARYLLLSILILFASTTMYMSTLIWNWSIIERLLSEANSGLFSDTYDAHESLAAFQNALHRQSTTASFALGANFIVGDAIVWWRACVIWRNKLVYFTALLTLTSTLATGTAGIFWASNDNPVRIVFMHGGDSRVTTAAGILSFMNNVTATSLIAYKAWSHRIFLRRHLGAEGAKTRLLRILALFVESGSLYCGLLTLIIAYMFDPAGYIPPGDAFNAVPYYSAGDYFVYGCLVPIVALYPITIIVIVALERSALELGSSLGNARSSPNARGPVAMSTVEFDPESTLSTSVTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHB6</accession>
    <name>A0A4Q9PHB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_832707</name>
        <name evidence="11" type="ORF">BD311DRAFT_666131</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143436">
        <property type="protein sequence ID" value="TBU27140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145261">
        <property type="protein sequence ID" value="TBU52206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHB6"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="113"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="323"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU27140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU52206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="530" mass="58345" checksum="39E0331234972E89" modified="2019-07-31" version="1">MQYLHPKYSADAARGHEYGSGPHPGAAPPVEQSHSHGSYGAAYDYASDRAQEFWDRLRGKGRRKIGWGESLKNIVLSSWLNCLFLAIPFAWASHWVTKKNAEGEREPLWGQDVTFILCFLAIIPLEGIFDWGGEQMALYLGKDLGDLVVVTLNNAVEAALAIVLLIKCELRLLQATIAGVVLLHLLLIPGVAFLVGGTEVRHQTLHPHQTDMNHSLLMIGVLATLLPTAFFAALDRGANSVAQGATDVSTALVNDNIRDEILRISRGISVALLVVYVASRIYMHNPPGENNALTVPHDAPPELKHAEQHLREEEPLTNPWACIILLLVTVAVMSVTAEMLVESIEHVRESSGIREEWFGLILLPFVSFSADGAVAAIFFCQAVYDRIANKEVQVPSMLARGRAIDLSIQFTLWWMPFLVLLGWWTSKPMHLLFDYFEVALLLGSCFLVNYITADAKTNWVEGLIMVAFYIMIALTAWYYPGQPSAEFMLACTETVAEAVSSGGSEATSELAAEAAKDALLVTHTWRSLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHR9</accession>
    <name>A0A4Q9PHR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145247">
        <property type="protein sequence ID" value="TBU52536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHR9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6367" checksum="7ED5967F1BBF41F6" modified="2019-07-31" version="1">MLIMQRHMIVPHLRPRPSSTKSCIHCLHGCLNGLSMTSRLLYRASVWELHDIRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIT8</accession>
    <name>A0A4Q9PIT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_936891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIT8"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="18065" checksum="565D45685A16A209" modified="2019-07-31" version="1">MAQPVQHATSGTKEALNALSDLAFAELLARKLASLASENEAANTRLGILSCLAAEALKEDFPESVAEEAPISDSELSYEETEESSSFDDANEHICPRFKSGERVRVPCESSPERWRYLHIADLTVFPPKHFPTYCAYPVLIQCKPRVVSYFDSKTLTRVDPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIU0</accession>
    <name>A0A4Q9PIU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_109117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIU0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIU0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20693" checksum="4B58EC7EA77976EB" modified="2019-07-31" version="1">MRTSVHTLHSSIPPTAPLYSTSYMYGSSSMSSMGQCPTISGRSSGVAIVNACSFIYFLSAMTSSYRSVGTQPSDPQPMPFRNPSIISSASLCSSSGFIVLRTSAASITTGYGASPPVRVSQDWQHAPILPLFLLAGLPQRFQKYDDPISQYMTQPSLPKDFDDLSESKKSRAKEVYRRRARWSRATSNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL86</accession>
    <name>A0A4Q9PL86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_979979</name>
        <name evidence="8" type="ORF">BD311DRAFT_809608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143470">
        <property type="protein sequence ID" value="TBU24937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL86"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF63">
        <property type="entry name" value="HIGH AFFINITY CYSTEINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU24937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU54953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="520" mass="58706" checksum="C2894BBD5B1A72C9" modified="2019-07-31" version="1">MSTKGSFGDSDEKNVVDVGVTHVAVADKEVDTAAQLAAALDEELSPEEANRIRKKIDWHVLPLMCTLYWVQFMDKTTLGSSAILGIRTATHLTTNQYNWLGTIFYLSYLVFEYPQNLALQRFPVGKWMSANIFVWGVALCSHAACKSFGGLFAVRLILGMCEGSITAGFLIVSSMFYTRKEQTLRVGYWFLMNGTAQIISGFLSFGTLHIKTKNFEPWQWLMVITGGLTIIVAVLYWFLFPDSPTNAWFLTQDERAKAVKRIQENQTGVENKHFKIEQFYEALTDPKTWLFALFSALDNIPNSLTNQRQIIVSSFGFTNLQTTLLGCVDGVIEIVTIFTGVQLAARYKDSRAYVGAIYFVPNILGVLLINFLPWSDKVGLLFGQWLTGVGTTGFVLSLSWLSSVTAGHTKRVTVNAIMLIAYCVGNASAPFMWQAKYRPRNHVPWIIIGISYVICPLLLLVIRALLARENKKRDAEPVDDKYEDFYIEVVLPDGTRTERRVDKEFLDLTDVQNRDFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLR2</accession>
    <name>A0A4Q9PLR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_857252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLR2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLR2"/>
    <dbReference type="OMA" id="NWAVVIY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="525" mass="57961" checksum="56649385D3CCAAFD" modified="2019-07-31" version="1">MSSTELHEKVVADDKSDTPGVQRSTVVDVVEAVDDDSYLELLGYKQEFKRDFTFLGLFSLVSSELAILPGVAGTIWYTMGYMGLIGMTWGWLVGAVMGQFLAYSLAELSSAYPTSGGLYYWAYMTTPPKYKLLSCYVVAWSMIISTPLACVSITYSAAQLLVACAQLGVPDYVAEAWHVYLVYFGMMFISYLVICLPTKYVSWFNIWSNALGIIILIVLTILLPVKAETLNSGKAIFTQAYNQLDWPAGWSFCMTFLSATWTLSGYDVAAHVAEETHNAAVTVPRSMVWATWSGVFLGFIYLISLALCAVDIDTLMADELGQPLGVLFAQVLGTKAGIAFMAINAFCQMACGIAFFVAASRIFFAYARDRALPFSDWLARVDPRTQTPNNASLVVFVLSAAFGAISIGSDTAFEAFFSGSTLAGQIGYILPVLGRCLYEDNPDYRNGPYNLGRYSKIIRWTAVAWNFFICPLVSFPEGPNPSAVDMNWAVVIYVPFQIIAMAYWWFVGYKTFKGPRPNFAELKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLV2</accession>
    <name>A0A4Q9PLV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_884732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLV2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025870">
        <property type="entry name" value="Glyoxalase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265">
        <property type="entry name" value="BLL2707 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40265:SF1">
        <property type="entry name" value="GLYOXALASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13468">
        <property type="entry name" value="Glyoxalase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="289" mass="31212" checksum="4ECF5762624690C8" modified="2019-07-31" version="1">MTGLSTRILDHIVHLTPPGTLQDSVHAFQNLGFTVSPGGTHTGGQTANALVVFADGTYLELLHFAAPPPPADPNPWAHKRPGWIDFAFLGNDGAPSVAETINRRAEEEGSGVRYAREVRGGRRREDGRVLEWLISGPPDGARETLPFFCGDLTPRDWRVPLEPRANTQHENTACGVAHVKLLVPPDALAATARQLTSVLGASPYSSTAEEVAWHLDLRPSRVAPPSKIPVLRVGAAESDEEKEYVRAHGAGIYEVGFAVSDSGQGRETKTPFGKIVWVGEDAELDLRVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMA0</accession>
    <name>A0A4Q9PMA0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_934156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145172">
        <property type="protein sequence ID" value="TBU55274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PMA0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052972">
        <property type="entry name" value="Sacsin_chaperone_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15600:SF42">
        <property type="entry name" value="SACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="2501"/>
            <end position="2584"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2655" mass="298135" checksum="F2C31C104A84A484" modified="2019-07-31" version="1">MTAFGERVDLTANLASILRRYPFSTGLFREILQNSDDARATKQVFVLDRRQFGTKTLIKDGLSHLQGPAFLAYNDAVFSDADWEAIRTVSESSKTGDTEKIGKHGLGSRAYYHLTDNPQYLSGDYHVVFDPHRWAFGQGGWKQSLEEIARDYPDQLEPFSSLLPHGDRTSLPGTIVRLALRPATAVSRISSKKVTADEIHDLLLDFVRKELDVALLFLSHLTCIEVREIGVDGAAKTLASVTASLRPPVPRLYSRTISTTIEASASTTREWSVIHASFEMEEGVELLCKSLEASKEWVEGEVVREKLRPNVALAFPTNASQGFRGRLFTYLPLPLVTGFPCHIHGVFSLTDSRQNLRNPSETIMRETADALAVAWNKLLFNTLIPRTWLEFLEGIAAGLSPTSLYDSLPPLQDQNTSGDAMYWTSLLRDLVKLADERVARIWPVFGLAGLPQAMRYASLQDVLVAGSGDDQTQLHALARAGVDIVVPPSELRRVLLDIRSAQELTPTSARPRLVASENLRSLSPHEKDRVVEFLLRSHDLRELIDVPVFTLISGATAALQAYRRDQQVVHVLLDEAATEVFGQFDANAISLRDVPPVACTLLVGSGRGALNVCPLDRDTVIAYIQSARSRFASSKTSTNGAWSWDETVGWLEEFWTWIQTSSLADGLQSDLRQLPLLPTIAGETRSVEDQVFSHSCEVADLVRNALSNLGVHVLDARIPSAYLERQKWIKSLSKASELLDVFFTVSLVIEDDHVAKILRAHLASCLRDDVSLTGTQQMTLRGLPIHLVLTDNVSESMQPLPPNNSLHCVDNRHDIALPLPLIPDATFIHCTTDQRPLIEQLDYSAVTRPLTMDRLLQLHADHFSMQTPHVRIKVLRYLVERRSVPKPSIAEKLWSSPIVLVGQGNRFLPPKDVVDPQSEIADIVPPWDPDAIYRDDSANSETTSLLAALNLLRRKLDVDFVVARISSIAHFDPSSEKGSDLAKRLLSVMDRTWFNWSDVSYDRELAWLPTTSGLRRPSDCRDRSHGMLCDRVLPILDMQQLQSAVLRHMLGWDAPVPLETLMEQFRMILAEPEHPSHPQYLIALTSEFGRRFGDMTSAQLDDVAAVARQARWVMTSGGELKQPAFAVFKLSVALYGFGQIRIDIAERRGVEKFLTRMGCTQRPHNDAIIDQLRQLHQGQAQAQASGLSDGTALDCVLLLQALNHGLLTSLQQEQILAPDVHSRLRTVQGLYYNDLGSRAIRYDIPNDRIQAHNNMSHALCIALQIPSLGSLHLQPLDLGFEDMREDLTTRIGNVLRAYNIEQAFNELLANASDAGARKFNIMLDCKEDRRADPSEVLCENMAQFCRGPALVVHNDAEFTMDDIRGICRVGRGGKEGKEDTVGRFGLGSLSFYHFSEVAMILSGSNILLLDPSGRFLPEDWRWNSYAVSLEKIKGLYPGHVRLFHDLFGYQGEDHYQGTIIRLPLRTEAQAVQSALSRRSLSTLDVSDMLERYQAVASRSLFFIGIEEITASVNQYDRRAPTEIWSVTAKRIEDIVSSGSANPRLLIDLSHSSQPLGCKTSSWLIATTVIAPESFPNWVQSVVDRHRLKQVSIALAAKISAVERNYLEQPSSEFHFFSSLPLPISTCLPMHVHASFVLADDRRNIRWDGDGMLYPEAKYNHWLLSCMLPPLYLQMFALFNERFGDKAPLPWPGNLERFTDPFSKTLVDAFFSDNLLRATPQRIFRSVTGRLIDPSTAVVRGGEPQAVKDVLDELCPEDLVKLPAYIRSRVLNLPFIRNTSPQYLCDLIATRTLHFLDAYRRHALTVAHVEAVIRYLLAESPMPTSSLVGLPLLPLADGSLSSIRAEGAHEDRVYTLPRGKRPWPLFPATRFLDPELDKDLILKKSWNVALWDESAVVALLRSTIPEAPRLEASESEWYWIVAFWRFFQSVSEKLLTALKSFPLIPTEDGRILVSLNSAIAFPAILPPAALDRDATLVLASLRKLGVVVVKTVFAQATSQLPQRVRDEMHSAVRFSFQRMIQILHHLNEDGRLQNKFGRLSDDEQTRVAFWIRGGLRDIPSVRANSPKPQFLDVVRHLPIWPTSRGGRPSGLRPLSATSLRVLPSSVKPVDDITRFLLTDTSFVECSHDIVRLQLAQPMSSGELLQQLKFPSFFRNSDALGPYKTLLNILVQLGDKEVSGRLQVPNENLEMLNIHAMYKSDVSEFTAAFTYRANEVFIHSDLRSYEVQLTSLGLRHALSFDNFKACVLAIDKDFKREDLRDQQKAQSVYGWYSTRLPLSVANDDDWRGLDSYAFIPRHHSRRLGSPTASEVAQFAVSLPLIVSPKKILRHQYSPIAWTQRALFPETPNKKLFLADEAVGVPTVEEVVEHLRVLATKIAPRYPGDSGLLDDLKATYGYLNEHHEDSQRFMVRCRKEALFLNVDNPESDSWTFLPACHIMLNVSDEDGFWEVRDFLRPFRDLLVVSGAFEIKIPKAAPPPTTSAEGLLTRLRASLDEQRRNKLLTDVIFRVTGEGEAGHEGDLWAHRALLVSASDYFNRLFCGQSGFSESRAASVEDPVVMSMEDELELHCTGLVLDYIYTGQFEETQDRECLLEMMTLSHRWELKDVQAHAEALLVPTITPGTYHELRQRAEAIEAKYLLEKIDEFERDNAYVLGDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMQ3</accession>
    <name>A0A4Q9PMQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_933556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMQ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="136" mass="15586" checksum="BBB01A8DA6206931" modified="2019-07-31" version="1" fragment="single">MGFEGLWATRTLAPHKRPDKSQLARAEQASTDPLRERYGISNTLTYPQHGRSVDGHWEDTGKNVSSIWWVIDERNLGVTTITVWVLSPRRLWVMGYWGPMGYGVEFPLSRLGKAKILWVFGVYGLPEVWVRRVSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMR6</accession>
    <name>A0A4Q9PMR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small RNA 2'-O-methyltransferase</fullName>
            <ecNumber evidence="11">2.1.1.386</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_1028512</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>small RNA 3'-end nucleotide + S-adenosyl-L-methionine = small RNA 3'-end 2'-O-methylnucleotide + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37887"/>
            <dbReference type="Rhea" id="RHEA-COMP:10415"/>
            <dbReference type="Rhea" id="RHEA-COMP:10416"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74896"/>
            <dbReference type="ChEBI" id="CHEBI:74898"/>
            <dbReference type="EC" id="2.1.1.386"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. HEN1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.386" evidence="11"/>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMR6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMR6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090486">
        <property type="term" value="F:small RNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026610">
        <property type="entry name" value="Hen1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404">
        <property type="entry name" value="HEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21404:SF3">
        <property type="entry name" value="SMALL RNA 2'-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU55552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="510" mass="57057" checksum="6B3E67173B4E99BC" modified="2019-07-31" version="1">MSSRGSEVSELAVTFHPALYLQRRGWVLDIMRREGVTEILDIGCGEGELLSCLCNPAPWLAPPPPDVLPPATDASPAETDVLKELHEWVLHPTRIAGLDICKSELECAARVTKPPEPDRDDVPWHSTPVRWEPLEVKIWEGSLEHVNAEYAGVECIVATEVIEHLPEHVLDRFAPVVFGAYHPRLVLLTTPSFTFNARFTAPDAPYEARSGWRDPTGRTDRIFRHHDHKFEWTVEEFERWCQSVAGEWGYTVEIEGVGKAQEKDEWGRDDALGWATQCAAFTRIEGGDWVTKRAAALWEASDRLHARTGSPGPHSLFASHRFAANDASRSPKPLDVVGELVLSKMLYHRETSIALNEIWFEREVELACGGWIDWLVRAIQEHPGLALRRTVLASRIDPHWTIELDPALHHLVPPPAIREDIWPSPPDTEELTDLEEAVDMIGSRQDGSVLVKDADLETYEEGWGAESEDAKTGWGNVQIDWGWGKAGGDGDRMPDFGAPEASGGETWTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMS2</accession>
    <name>A0A4Q9PMS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_933677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HET"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="274"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU55455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="703" mass="80619" checksum="2C4332357F1F081C" modified="2019-07-31" version="1">MRLLDTHTGHFIEVSDISNIKYAILSHTWDTGGEQTYEEVRNIQIDYPIQRVSSRAKQPSIAWASRAYSRIRRRCCRRSSDRDNDVADSEDWPSDLWGDHRLAEKIKKSCEVARNHGYRLLWIDSCCINKSSSSELSEAINSMYAWYGHATICYAFLADVPYMFDYSEGSPFRDSRWFKRGWTLQELIAPKHVVFLSKDWRPLGSKGTMAAVVEEITGIDRQVLTHKTSLDTVSVAQRMSWAAKRETTRTEDRAYSLLGIFDLNMPTLYGEGERAFQRLQEEILRRIPDQSLFAWGHVCTWQNPLPVSPTGIHDLPRGYGVDLPQNGSLSKHVTSFFASSPSDFAMSGTVGSMAEDDYLRCVGESDVPHLDYTTTPYGIRSQFLVLPLQAYFPDDEIRAELQRDIDDLSELYLAILHCHTSQLNIGRPNHCLARLCSIVLSPSKGEVVRGREMRLRRQDPYKSTRFEYEIRTFAVLPLTMTKLKDCLHHLRIRSAYMPHPDRTVVSRAPTSFRPYRTFDDPGDLKLSPYTTLVLHAWGYDVEFREPTSGALAFTYSLILRRRQYVLQLNISDFRHLVSLVGGRYVNVAAAWLFTEEEAQHHRLPLSTYQGPVPHGAARYIDDAGFRPIVLRKPNNGLAIVIRLGIEREETSDYSSSYFVHVEVEESDTAHYSSGGSTVDVMPELEEARRLPERYLRLYQRPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNB1</accession>
    <name>A0A4Q9PNB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_669407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNB1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6517" checksum="8C68BA29C2B32D99" modified="2019-07-31" version="1">MATFTGHIDSRPIPDMRKIPDWLLNHPELHKRGVVLHKSLQPFTKRNGQRKVLSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNP3</accession>
    <name>A0A4Q9PNP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_652146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNP3"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21737" checksum="5AB3E12652FF6903" modified="2019-07-31" version="1">MFDCNTYSTGTTTTGTARSGPTSCAIGDVCVLRESLAAAVEYIFQATEVIRQDPVALQRSEHALCDLGTLGNIVRASLCGTRALARAPQLSSSWVHSKAYQSNTPAASIPNIYREFCRAIFPNLGLPHSTHFHTTPPWPHSSQWLFSYPVSLGDSNLVVTAHWRFKGQHAYSGSMSCKSVVIVILSSHEPLKASGGRGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPE1</accession>
    <name>A0A4Q9PPE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_932089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPE1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020549277" evidence="1">
        <location>
            <begin position="21"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="16903" checksum="1E18A7DC2890E55F" modified="2019-07-31" version="1">MFSKLVPALVVLSVLCGSYASPATEVTYIPPGQTNGVESATAVAVGTNSDGHITYSIGFELATAIAPTATAPDTTITAAATLVEGPSDAQFVEVLTVAGQTETVSEGCTLEKGHGVCTVVADFAHSTLSTVVTVTSSLSVSGKGNGAGRIGVATISSMAVVVAGVVLGAAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPE2</accession>
    <name>A0A4Q9PPE2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_633956</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPE2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPE2"/>
    <dbReference type="OMA" id="EEHTYKK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020449762" description="CNNM transmembrane domain-containing protein" evidence="9">
        <location>
            <begin position="16"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="35"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU56190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="462" mass="50354" checksum="5E84CD478CB46C1A" modified="2019-07-31" version="1">MLLHLLLSFLPSSHPSPSLPLNLPDGSDEPGEEFGSPEFWYKVVLSIGLVLLGGVFAGLTLGLMGLDELHLRVLSTSSDDPKERKNAQKVLSLLRKGRHWVLVVLLLGNVIVNESLPIFLDSALGGGIAAVVISTTMIVIFGIIPQAVSVRYGLSVGASCTPIVLTMMYLFAPIAWPIAKLLDYVLGTHETHTYKKAELRSFLAFHRQGEEPLRDDEISILNGVLELNNKKVEQIMTPMEDVVTISADRVLDHATVDWLLRSGYSRIPVHKPGHPLTFIGILLVKMLSVYDPSSSIPVSELPLSLLPEAPPTINCFQALDYFQTGRAHLLLLSRTPGIEGGAIGVITLEDIIEEIISEEIVDETDRYEDNVSKRRASRMKNAAVMKGIVEYRVGRANSLPEVGDRTPLLGSRNQSPMPLYRGGAESDGALLSVSPQPASQRRISNLNPQYGSVIVGSPNGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPG1</accession>
    <name>A0A4Q9PPG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">YL1 nuclear protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_882999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPG1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPG1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="533" mass="58449" checksum="2AFA5BC75E5FF4B9" modified="2019-07-31" version="1">MDDSLVARRPKRSTAGNRMEAALAEFKAEDIGMDDEDADFALDKEEEDVFGSDFESTDEEEVQEDVDAAAEKLIRQDESRIRKTARTQLERITALAHARQAATFNPTSIAPTPERPKGEKKLKRRVSLGVAVNAETGEVLEGGAETEEPDAPATPVTGGKRHSTRTHTVANTSATFSRARDELRKQASIPKRAKTNIKAPTQEELMMRALSMEAGNIEEHTNYLTLEEEKRRKARAVRASVQGPLIRWISKKEEETVLVQPPLPTPPPATPSPYIPYRRHSTSLPALASPVTPARHSNTLALHPSQYTSMAPQPSPFQQWPSSTPGPPSQHQPVPPLPSSPAVPMSPSATGTSAPANPTASPYTSFTNTASTYTHAPVQPFVPQQSPPQTPASAMTFARVPTVATQPSSAMPPPSQPIERKEIVGKQYVIHEITQSEKPRPSWHSTMTAMFGDHADWENCRVYTTKGRPFARPTQICPITGKVAKYLDPRTNVPYADLNAYQVISKVLRHEYVWSPSLGCYVSREGSVFSSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPP4</accession>
    <name>A0A4Q9PPP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8273" checksum="04BEB3E5C66B1D30" modified="2019-07-31" version="1">MRVWLARTRGRQAGAALRYLVWMQASATAGYIAMVCTFTRRTFPLRSSLDSLTFFPQILPAAAGMALVHVREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ67</accession>
    <name>A0A4Q9PQ67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_931268</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ67"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ67"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32183" checksum="80B49B2DE196A532" modified="2019-07-31" version="1">MAAFNMNPESTTTTAVPSPIIPAVALPKLSPTHTLAPQLATTEPSIPTPPLSPRRDDEFYCQDVVFLVGGVLFKVPRRPFEHDSKAFSDTFGLPPLNSAYGVEGSNDDNPIKLEGVTEEEFRPLLWVMFRAGYGSARILTQPQWTSVLRLATMWIFDDIRERAITELSRLVTSPAARIVLARRYNIPGWLEPALTTLAQQEQPLSAQDLEALGWETAAKLFQIRESVTFTGTCVCGCNYCTVAHGHIANATAGHAHGHGQQLPAGARAGAVTLAALRKQADFSQKIRVVFGADLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR65</accession>
    <name>A0A4Q9PR65_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit DUO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein DUO1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_930654</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DUO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR65"/>
    <dbReference type="STRING" id="114155.A0A4Q9PR65"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013960">
        <property type="entry name" value="DASH_Duo1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28216:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DUO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08651">
        <property type="entry name" value="DASH_Duo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="210"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU56853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="309" mass="34285" checksum="63D7CF0E41F59896" modified="2019-07-31" version="1">MDSFDFSNVDMPASGSRLLSEPTPDISSSSSRTGHGGDDLSLSELSLSDRPQSKSARRRPFSLLAQPLSPDESAVADDEDTEEGGGGQDETMTQEDVEKARKVAAKTREEKLQHDLFVLKKLNSAFEVYKDALRETKSSTDRVAERLGHTNALLDKYVRILSGSEKITKLILDERWQGAEADEEQLLREEEEERERARREEEERQLAAQRERERLEREQREREERETRERLEREKAEAAKTASRGSGVRGVRGTRASMRGLRGTARGAPAANARGAASATSGIPATRRGTTSMATRGSTATRGGIPRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR72</accession>
    <name>A0A4Q9PR72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_949860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR72"/>
    <dbReference type="STRING" id="114155.A0A4Q9PR72"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF281">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="39660" checksum="3F53B61A7E5CDB50" modified="2019-07-31" version="1">MSTALSLLYALRKLKILSRSHDRSPYHVTDIPNLSGKVALITGGTQGKGLEIAKAFASAEARVLILARDEDKPDVALLQVKQHCRAQQIFSPDVNLIQCNLANLADVRRVGDIVCEQESRIDIVVCDAGIGLQSFDVSEDGMDRHFAVSHLAHFLLINRLLPLLHRTASVHPHSDSDPPSPYRAPTRPRIVFLTSALHSVAPPDAHFISNAELSSESGSADSPLALYARAKLASVLFVKSLARHLDQHVLVLSVDPGAIHPKQPEQLSRAFGAVWGSALRVLTSPFERSVDEACLAALWAATAPELEEEWARWQGAYVSAVGVAGEGSEMARDGMREEQLWRMSESLLRTSLGEDALRPWSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR99</accession>
    <name>A0A4Q9PR99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Na+ dependent nucleoside transporter C-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_930513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR99"/>
    <dbReference type="STRING" id="114155.A0A4Q9PR99"/>
    <dbReference type="OMA" id="IVWHTVI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="269"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="372"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="588" mass="64345" checksum="DAFC18BF36A27E1F" modified="2019-07-31" version="1">MTTEILAAPHLAEEQRLARKQSRSSGSNSIAKGDPAADPTDVKVTDPEKATSKESQYVEEDEEDVSGLTKLYRRFRPLVLALLAAVILGWWVSATVLKATRHRWIVQTFWAWFFIIVIAFRFIPNSVVTRPVEAIWVPCVQTPFLKLPRYIRLAMGWLALLGIIFGSAFGFKLTGNTGYGDRAISVLGLFVFQFCFWATSKHRSHIPWPTVIVGLTLQQAIAMFVLKSGAGFSIFKWIAFLASDFLAQALAGAAFFFDQATVDKHWFFVNTLSSIIFFIAFVQMMYYLGVMQWLIEGFAWFFFKIMDISGAEAVVAAASPFIGQGESACLVKPYVDYMTESELHLTMTSGFSTIAGSVLSAYIGLGVPPENLVTASVMSIPASIAISKMRLPELDEPVTRGRVTVDRGNQNDKDRPANALHAFSKGAVFGLIVAGQILTNVLTVVSLVAMLNGLLTWIGKGFGIHALTLQLILRYVFYPVTFFMGVPRGEILRVSELLATKLVENEFVAYLSLQEITKSDSPLSPRAFTIASYALCGFANLGSLGIQVGVLGALAPSRARIISRIALSAMICGFISTMQAAGIAGMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRC9</accession>
    <name>A0A4Q9PRC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRC9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="17342" checksum="033C532DB262FF24" modified="2019-07-31" version="1">MKLRSQIFTPGLYLPWRSTRSPSPAAPSTRKRDPRSQRPARLARFHHRRFRTSPGLRLCTQPTTCPQASRRGRVLWPTDEQRPSPMHHAQDSVRPPWRPDADVGHTLRSAVRRWESLHERGCMLQSEILTALMEGEVPIWVQQIQERAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRN1</accession>
    <name>A0A4Q9PRN1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_589258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRN1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="69"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="241" mass="25709" checksum="3450440CC142324A" modified="2019-07-31" version="1">MIVVTAQGFFARRAYIFGRQYRILVCIAVCFLIGELGCCIATTIVEIQSGPFTSFVPKTWVIALASGLAVVADIILTTVLIIALRQSRSGIKSTDSLVDVLVLYTITTGLLTSLTMLAVFLVTAVGPADMGTYTAISIVASKLYANSLLAALNSRQSLKGRAEAHTVGTEIFGTEVGRQEHKLASAPVSLELRVNSGSNRFTATTVNTSRKAANGDQLGNQDTHVEGFKAPNTQRDLVHIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRU3</accession>
    <name>A0A4Q9PRU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8358" checksum="4DADA8034F0DC281" modified="2019-07-31" version="1">MTSPSHRGYIRANERQGPTVSARGRHYPPCPKQPPSGPAAPVMSPCDRAPPSSQVHLMRLLDRITSATCVWWYLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSA9</accession>
    <name>A0A4Q9PSA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_561193</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSA9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PSA9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="187"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="602"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="802"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="627"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU57289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="877" mass="96412" checksum="CACB8BC171C3DE64" modified="2019-07-31" version="1">MHAVMKRLTHSFKPLLGRAGRSKTSKTGSHLGAGEDWKQAPDSVPMIAVIPPLEDMHVYMDEDNLGNLIMHDVQCLPVVEDIFVACRSTTLAHISTEEAVDSKSNVQPSELTKASEPEQPKPLSVAEQRRKFIASLPLPPPPPIKPACQMPPELLTWMQLFQGDILDDEENGEGRTQLSETLGTQQLLVLSLLGKGAQGNVYLVKHRSKMVFYALKTIPKSTDKNGHYANLFAEQFALKMVAGDPRFVNLQGSFQDDECFYILTDLYAYGDLRSEMREVGKYGEEKARRYAVQIAVSVEALHKQRILHRDLKPDNLFLNSRHDIILGDFGLCRIFGRSIAEQPWRGAGVRAWMLPEDHPSQKLRMGGADKAKRVCGTPRYIAPEVYGLESDGWYSYSADIFSFGVILYELLHGKLPFGMKNDDVVEHLVVRTTRAELEVDQDVSEEAGDLLRLILAKDPGKRPSWAEIKQHAWFRSIEWDNVAPKSQPPTPIMFEHFDPSSEARATKFGKQTANNDPPYSFFDWTSPEIRCQPSVSTTSMYKVSRDWEPNADILEVMGWPVGCSQSDFATCPPVKPSPVHRTPLVVPGPLSTHQSSSAIFVQAHSGGPDPSTPDPSSMSPTSAISLKGKKAHSQHGTSKRSTHSEPQALTRAVSALPASSPFSVLEVIDEAPVASRASSFDCVDIAKALDIMDSAILIHTRGEVGAHCSRWSSMPSNANVDATMTMPSTGVSPFFKCLGIDRAADLVTGSMALQPVRIRRDSSTILPFSDTVPQTLLDAGVIKSMSLASVLMDTPIMPLRYSSSATSSSSQGSADDSTSSTAGTGSSTHYWSRNASSFSPSWGSWGRLSSRVKGWWSSVAGAKEARRREKRRAAAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSW1</accession>
    <name>A0A4Q9PSW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_549052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSW1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="641" mass="72845" checksum="8D8C2C15A027CC1B" modified="2019-07-31" version="1">MAYNLRPRKKNKADGLRPKPDAETKSSPMPPIARLPTELLTTIFSLVAPFETSDSDVWDAKTWMGWVPLMLVCRHWRNVGIATPWLWRRISITCNLEALQYRLSRAVDSTIDLFLSRWREDNKKAMPLLLPFARSIRSVQAPEFPWSPLERFEEFFTFDGLPCIRPLFEVPLPALEHIDLSKLDVLQNRQLEAPFDLGLSEKLHPSVRRFIVTSHIKIPSTPSFWSVLRELDIRFDPSANRWTRLDDFLQVVAGAPYLESLIVLGTQVSLPLSSWATPALADDVPTSLYRLARLRIVRLDGMLTFIAPILQRIDAPALCVLYISASIPRNADIADSTKLLFPLRLRHVLAKCTALYVSRNDPWDFQICSDANWNRGSIRTAASAIHVPLYFRVTSYLKKLSSQPSTAESKLSTVIGVLCDGFCTAPLRTLSFEKFYDAAPVAAWRLPQAAFPDLQTIRVQSEDLGVIRHFFLALREVALKGGWPSLSRLEVDFGYEYEHNSLGWHVVLQPLVEAARTWLEQGLGLDDIILQRMHITRWHFGPHRWALLSIAALCDRFTLRDSFVDDDFFYDALEPVSELLTTAQYHVSTGQQAENTADEDPKQAATDGTEGGSLEVELPEIEGVRQLREKVLAQLLQRFCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTE4</accession>
    <name>A0A4Q9PTE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_928565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTE4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="21"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="308" mass="33910" checksum="166C9E0D20C619CE" modified="2019-07-31" version="1">MSSSQTDMLVAQFASYLRENYCFLAGAVLFIYDSVIMTGEEIRCFWGRKVTGASVLFWLNKYIAMLYFVWILATYLGLPNKVCDPTSRGAGVVEISLYIVLAAFTGLRVHALRRCSLLSLVTFLISAARFSFGVNGEITAFGCLTVDKTPFNFTKMYCSFAAIIITTVIIVSRSCQIAADCVAIGVTWFAMHQGYGIRHMAGRKGTLSRVLLLDGERLDATLLQGSLSDVTYFTTPLFAICLSRFLLHLQSANLRALAGMDTSEVLTASQNSSLVFERVVGSIGAIIEPEDYLPAKGDWEDSSYRADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTP4</accession>
    <name>A0A4Q9PTP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_959316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTP4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="716"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="736" mass="80567" checksum="FA5A8A6CF7A6218C" modified="2019-07-31" version="1">MSCSSGSPRFAVLYDSLPTDVQSAIVQKQLIPLLDHASKARRNRVLSSAAKMHRRHARIPALDLRSKQREVNALLDDLHRDAKRSFVHDRSRRTELLEQTVESVTCWLNDIWRVVYEHNVDFMLAHRCLVFTMNTIDQIGHARASCRCALTSMYVPITIKRRSGKVVKSWEVNGAHNVGEVLEFIWRDLFLSMLATGTRRQIEKIPEMLDDIEDIMGWTSLERLLYGGRKCPHDEYGPDEEWSDVDSDIDEDEDAYTDDDSDLDGPVSDADWVPKLHRRTTPSHAKHWSHRISSQVWQFRKHVHAAMLAVFRSNPSLRLYSALLASSADPQTTQAELTAFLSESATSSPDVFAAALDIHALENNTSAIADLLATHAHLLRPRDAPTHQCAVTTLASDPAYHSRALAIIEKELLDTARTVRAALVSSVFSRLDTLANKTELDAIVKLRSNAAGRQDRVERWVDAVTTPGAVGPNPMALAALVMGIPLPVGPGGGPAALGFGGDGLDGDADPLGYLDLDPNDPDMEDLREEFRPRLKQRFEGWTDVAAAAGKSGAGVLARMYRELVRSMPFLRASDVVEEMLARVSEKPGKQHLIDAVDALSAFVKVQRRKLAASKSEQKRRANAASQTASSGSGPSLHLPLHPHPHPGMPMFMFGIAQTTPEESDTVPDRPETPPPPLEPISPAQANHEYAGPAAPAPLFTFYPGMPAPAPPPAVPTGGGGGDGGGYAGWNGMDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTY6</accession>
    <name>A0A4Q9PTY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_1039452</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
            <location evidence="3">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTY6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070260">
        <property type="term" value="F:5'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09080">
        <property type="entry name" value="TDP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051547">
        <property type="entry name" value="TDP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822">
        <property type="entry name" value="TRAF AND TNF RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15822:SF4">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="12">
        <location>
            <begin position="165"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU57977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="426" mass="46752" checksum="D1D268B6F5655DC0" modified="2019-07-31" version="1">MGFHLNAFVGAIHKLAPSAPSVRSRARRLHMASQNSPDSFGAIFDKQTATASPIEGADAVKVVSSDQVPEHTDQTTPYGNDNPGAPSVASSPASPSHDANPPLSPLAELSPVDSSRSDSDENEDTYDMQYDTVRNLRVKGWSPEESRWTTKYHKHSLSALHIDIVSWNVDFMAPDTAGRVACILDHLRKAVLTDEPQATVILLQELDEASFAKILENSWVRKYFAVTPPTTRRWQASYGLATLVSRPAWIANAQMLQFSHTTMGRAALLVDVSLYPPSDWPNGPNHVIRIANTHLESLPMGERARPLQLQAIADMLRAPGVFAGVVGGDMNMIGPADQRIHIAAGLRDAGSDGPESLTWGFQPPSRFPPGRLDRIFYTPSPDFIVKPVKVIGRGLKTKRGQWASDHHGLLTRICLRHDDDDPELDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU78</accession>
    <name>A0A4Q9PU78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_879775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU78"/>
    <dbReference type="STRING" id="114155.A0A4Q9PU78"/>
    <dbReference type="OMA" id="NWEDERD"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="26473" checksum="9B73ECFC1E9036DC" modified="2019-07-31" version="1">MSEASSTPGPSSSKPDQPSADDIERLLNREATAFQREIEVERILKAFKLNPYEILDISEEASTEEIKKKYRHLSLFIHPDKTPHPRAPDAFDLLKKAESELSDKTKREELDAVIKQARVVLLKDLGLPPAMRDDDPKLKSLVPSWRQQVLAKSKEFLIDEEVRRRKAFKMNLANEGLEARKKEEEVNAKKRKAEEEARWEENREQRVDNWRNFASTSKKKKKTKVAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUQ6</accession>
    <name>A0A4Q9PUQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Emopamil-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_819739</name>
        <name evidence="2" type="ORF">BD311DRAFT_752699</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUQ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUQ6"/>
    <dbReference type="OMA" id="LHSPIWT"/>
    <dbReference type="OrthoDB" id="60858at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37919">
        <property type="entry name" value="PROTEIN CBG05606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU31490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20550" checksum="609F29DA6DC4EFEE" modified="2019-07-31" version="1">MAVKTHTLISLWFALTVPVIFWDATYCFFRPRSMVGGDLHWIWTPYALYQEIDYVYGLKALQEGSGFTNAQSALNVVENFMNIGYLYLAHVTKSPVAPLLGFASATMTLSKTVLYWLQEYYCGGCAVGHNDFKTLFIYWIIPNGLWLVFPSYILYVFWNDISSALHLADRATAKTKSKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV22</accession>
    <name>A0A4Q9PV22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_906609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06121">
        <property type="entry name" value="cupin_YML079wp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009327">
        <property type="entry name" value="Cupin_DUF985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039935">
        <property type="entry name" value="YML079W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387:SF3">
        <property type="entry name" value="DUF985 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33387">
        <property type="entry name" value="RMLC-LIKE JELLY ROLL FOLD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06172">
        <property type="entry name" value="Cupin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF985" evidence="1">
        <location>
            <begin position="16"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="212" mass="23679" checksum="B8CD6FFA9556C120" modified="2019-07-31" version="1">MTGSDEYLVYAIPNSELIDQLRLIRHPEGGFFAETDRQTKEIPSPFADGALRTLATTIYYLLTPDEANGVFHMNKSATMHVLHQGRAEYTLITPGTPPKIERKVGLLLNLLVTVSANYKAPQVIGPNIHSGEVLQLLVPSGVWKMSRLLSADLIAATSQEDGKERYGCLITEVVFPGFAWEDHAFLKRAEFDKLFENSDSAEVKELIKYLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV23</accession>
    <name>A0A4Q9PV23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_819696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV23"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="420" mass="46511" checksum="93B82B468651607A" modified="2019-07-31" version="1">MHGISIPAHQYSRFAETYLQLKGRREWEWTRTLAAACRSFTRVVLRLRAQAEAEARAASAVARDRARSPGSGWGGSTTSVNHIPQGMQKRSFSRGSSRAPSPTSMFSRSHHGHPGHSRNGSQAGQALHHSQSVAQFHGPGQGNGTGTFQSPLFRLRRAPLLQVFVPSPEGEWLSDASVLECEQELKRAGVLHLLRPGDVVWDTAVGDEGNMGRLMWDGSYLIDLDYTYSRSGDLPKYLPTLAFPPSYFHRVIRTMGSGNPICHIDISPWGEEVATNLQLLQDRMKTETPQGGHHVVVRWVHRSSFTVRPPPSGKPLRISVPKSIGPGPGPGGTWFVDPGWYGTVVVEAEGTNEGLADLQERCRGAFPIRAIGANPSLSVSPEREARMEERRSVFRIMRERSRPGEIWIKTVTEKERLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV94</accession>
    <name>A0A4Q9PV94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_819528</name>
        <name evidence="16" type="ORF">BD311DRAFT_774814</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV94"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV94"/>
    <dbReference type="OMA" id="TRFHDFK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18045">
        <property type="entry name" value="DEADc_EIF4AIII_DDX48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000498">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="55"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="236"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU58405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="397" mass="44850" checksum="8E86E4E63A7F6A8D" modified="2019-07-31" version="1">MSGGINPGDEKLIFESSEAVPVVSTFDDLGLKEDLLRGIYAYNFEKPSAIQQRAILPIIQGRDVIAQAQSGTGKTATFSISILQSIDVTVRETQALVLSPTRELATQIQSVLLALGDYMNVQCHACIGGTSIGEDIRKLEYGQHVVSGTPGRVFDMIRRRSLRTRNIKMLVLDEADELLNKGFKDQIYDVYRYLPPATQVVLLSATLPYDVLEMTTKFMTDPIRILVRRDELTLEGIKQFFVAVEKEDWKFDTLCDLYDTLTITQAVIFCNTRRKVDWLTEKMRNANFTVSSMHGEMAQKERDAIMAEFRSGTSRVLITTDVWARGIDVQQVSLVINYDLPANRENYIHRIGRSGRFGRKGVAINFVTVDDVRILRDIEQYYGTQIDEMPVNAAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVH5</accession>
    <name>A0A4Q9PVH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_453789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVH5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVH5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020235737" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="28"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="84"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU58632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14072" checksum="4CF5F9E4E8276E57" modified="2019-07-31" version="1">MFPRSIVAVIVVAAVCSSVDAQVSNCARNYTVVSGDTCDEIAGKENVSSFQLATVNKATINAGCTNLRAGEELCLGIVGQDCEVTHVVANGDTCESIAEAAGTTLDILLENNPNVNSECNNIHPGEVLCTAKDVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVT8</accession>
    <name>A0A4Q9PVT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_476756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVT8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17807" checksum="F89090404E8E8791" modified="2019-07-31" version="1">MSGRIDATVIQYAHQYWKNVEKTPPTRRAALEPTAECLFTADSKSNLDTIMRLSGARRPRSRVCRLCIENPSLHIVRTALSNSTLQSTLRNVHPITRAIVVAPPMSRSELRLASAYLTTYADDEKAGPDEEHALGSHSSRLEAGRLRVLAPDPDMGASSPSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW08</accession>
    <name>A0A4Q9PW08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">High mobility group box domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_765564</name>
        <name evidence="5" type="ORF">BD311DRAFT_602290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143447">
        <property type="protein sequence ID" value="TBU26363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW08"/>
    <dbReference type="OMA" id="LHKEMYP"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051356">
        <property type="entry name" value="SOX/SOX-like_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
        <property type="entry name" value="FI18025P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU26363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8644" checksum="29E6D7F885E85C2C" modified="2019-07-31" version="1" fragment="single">IPRPPNAFIIFRMSKCADFTDAGVESDHRIISKIFGELWKKMGPEERAPYVEEAKRRAREHKMKHPNYRFSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXH9</accession>
    <name>A0A4Q9PXH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_877246</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXH9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="92"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU59285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="238" mass="25784" checksum="D5BEEA8E7B8E9B30" modified="2019-07-31" version="1">MAPRAKASTETVEPARRSSRISAQPKLEPVEKPAKKAAAPKTKKRTAHAEDDEGGEDAPAVKKVSLQLISHFWGFLRGALGHIQENTALQPIDIGDVLPSYTLKNEKDEDVDVATLAAEKGVVVFLVPKADTPGCTQQACGFRDIYPDFTSSGFDVYCLSADKPAAQTKWQTKKNLPYPLLSDPKRMLITALGAGEGGKTKRSHFIFEKGGKLLDKKILVKPADSPKLALEFVKSLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZF9</accession>
    <name>A0A4Q9PZF9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_976159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZF9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="456"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="300"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="739"/>
            <end position="838"/>
        </location>
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    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="108"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="199"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="316"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="769"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="821"/>
            <end position="838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="838" mass="90101" checksum="04F0E77603CD3BF4" modified="2019-07-31" version="1">MLVFTSLQSQVFVRPASFPGIYLEDQYLDGAAQRAAHDYALAHARVEAIERQRELYCHRLGSHHQFRGPGHFPRRHYGRPSTDFRQGFGSSPATRPTFQPRRAPSYSLEELELAYSVWQQEERILSQQREAAAREREEVLARQREAQRQRALAEAAAREEQVRAARVARIRAQQARDQEVLHALLSQLGLAFVQAQSAQDTPRANRQQPTVSTARPAAAAASAPSPSPAPVDRKGKGKAVDVPASVPTPISTKLAHAPEHTEVPTLKEELEARIRTESDPEVQQSLVLLYSDLFDIREPSQSVAGPSGTNHASFQIPASGPSTPSIPAPATSPVSAAPKPVEIKSTTTAAATTSQPEPVTATGREKDETRETETEGAPLHRTPALPPAIAAKLLKFYNARRARKLSLAEIKEVEDALRKLETTFEFPAQLDFVSDPLPSPSALGYTTNNAPVHAYEHALNQLLTRLDGVESNGDDEVRGRRREVVKEVERALEAMERRVEESRGRSRERDPRRRASVSSQASDGEATVTPYNLHTTDNVDKAETEEVVKAPAEVEETRTVAPVEVNTALGSTDQVEAPEQGPSPAEAQPAAASSPLINATTDDGVPRITAGVPDSGADIDALTDDEFIHADPSSPADEIDFADGTIDQLESAKPQSSPATAEAATAPSRASDAELSPVSTAPEDSPHTQFEVAEEDVAAPASEYAEDTNATAPLPAPAVAAPEAISRVASSATDETFFTADTDSEAIPLSATDDGTFFTASTATPVEPASLPMSRSASSSSAGQDTFLLSSTPLADDQPKEHRPSGGDDEELEIISTDELEAARNDSDWSDIESHSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0W0</accession>
    <name>A0A4Q9Q0W0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_267955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HMG_box_dom"/>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45789:SF2">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
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        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="558" mass="60122" checksum="F239F0BFBBE97D3C" modified="2019-07-31" version="1">MPPPFDHEMEFDDDDGMPPLVDNPLPPMTFTFAADLPPISYNHEFAMSEYAPEGLAPDMNVYSPQDTTMPDLPRGSHAKKRDASYIPRPPNAFILFRSSFIKGGHIPGEIEGNHSALSKIIGKCWKALPRQERKVWEQKAIVALAEHRQKYPDWRFKPAANALAKVKDGPRKRGNRKGRGQSEKEERSREKRCAKIADLLVAGKTGSDLAAAVEQYDCETSRGRRPKDEGPTEGVALSMMQSQDEIRDIHSADADVKVRSVVGSDMPHTPTLTIATDGLDVKPLATRSAVDGRFKVPLTAMFKRSSSAPAPRARTPTGGPRALLSHRRDSFSAAPPLFTRAASFDGSGVPPEEILAIQPDSGAAREGTGHASADSVSSIQTFSSDVNDAGLDAFGFAASNLSSPHLPAFERDAEGFNSPLQSPIATPVMFSWGHESDIGTPTSISDMMGEAYAPAPSPSSYSSLEGWAGSPLPKLASPISSPLTKVYHYVDGTDSPSVMKKAFDAAACAAYDFSNESFGHGDGFGAVGPAHTAHYTWGSDAPFITYAFPVVQCRQDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1S3</accession>
    <name>A0A4Q9Q1S3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_239391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1S3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17522" checksum="AAA8ED349FC1FAF7" modified="2019-07-31" version="1">MRVVLHDWHDNCAINILKQIRKSCHESSRVLIADCMMLPAIPTRLEDCNSQGSFEEVLNDVSNISISPSHAVMSFLQSLISLQPYQLMPAPYPLPQNFGFATKAQNLFDVAMLVVVNALERTSPQFEKVLAESGFKINKVSSTRGTATSTPNLGRFPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1U9</accession>
    <name>A0A4Q9Q1U9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaps-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_846265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1U9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1U9"/>
    <dbReference type="OMA" id="IEAYQHC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034044">
        <property type="term" value="C:exomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000149">
        <property type="entry name" value="Clathrin-coated vesiclec protein (Bud7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015374">
        <property type="entry name" value="ChAPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31975:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09295">
        <property type="entry name" value="ChAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="739" mass="82637" checksum="3F922C008140F6EC" modified="2019-07-31" version="1">MADASFRDVPEIFEVELGESLTSRTECLSTFRELGPPDLVHVLKSTGRSGQRDLGSYHYVSGVDASSSASLAAYINSLTYNIEEEAGWFSKGTTWKVKSGCYCCFNAFSRVDVRVDVKIPGGVQAYVVDLRGERHEATPEIWQETSLSALLRAILYSDDPTYWLEAYRKLDPITNPEGELRFLQAAEALFLKGWQVGSDPEIQVATVVSNHLTAALMKYFGDSGRFQYAANLFEKITAKEPEVASLLAKSYLGMNEEVKAAQIMASAIKQTPQSYTLLHVQCEFLRSKGKHEWALRLARQAVNCAPSEFVTWEKLTECYIDLGQYENALLTLNSCPMFTYNGRDAHRNLTPARVHLPPKGTIVEILPERIKTEDDEADPALLRLPAPGLRGTWARAYALLTRLVSQIGWDELLKTRSSVFVMEEEYRMQKAHADAQPHSAKQVIHEDGSVASPQRGASIQGKAAADDDASTRGMASPNDSASDQDGHDEKPEGDADSVTLASTNGLPTIRISTESAREQKAAANGHDEANENGVKETVGDALEKPVQAAENQDGDGGQTPSQEPFSFSNKRLCERWLDNLFMVLYEDLRVWTIFRAEVAHFKTQHVAYRKTGLEWEILGDLGMRLHHKEEAKEAYQRCLDTPRYSSKPWSKLLDMYADEGDIQRSLQAAVRVAAYQWGEYAEMTYPTQIARSFFKLGQIHGHAKIQWSLLSMGLPEPVMKIMESYLVYGRTFKVEGYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q320</accession>
    <name>A0A4Q9Q320_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-carboxymuconolactone decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1037018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q320"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26496" checksum="3F82721F605844C3" modified="2019-07-31" version="1">MCIKTALDSESRAATVALERLSTRLAFLFFAFTALANVVIATKRVVVKRDDNLPARVPYVFPPPGTDAVADAIRRRRVNGTLLDLDGVLLQDEGVASSWNDFFGVIRDNNSLPATMRELFILRTGVLNNAAYVWLQHEPVGASVGLTLNQLREIRLTPTFASAHTPSTSLTPELSAAMVFADFMTKSVQVPQTVFDSLHKFLNDTQMVDAVATVGGYNFVSRFVVALDVDSKADVPVPIPTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4I7</accession>
    <name>A0A4Q9Q4I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_123489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4I7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="36082" checksum="D9FE644885DBDF33" modified="2019-07-31" version="1">MMAKARADSRCRRLPRHRFGSMCFHRVRVSLIRHSPTCSRHLPPGTSASQQRPRIVCAVCGQRPTVQDRSLSLALCPAQTGSRLLLGRSERHHFPMLYTLNTGLSFYPGFPITLRASSECVACSQHDIPHIARSLCTLQEATAFPVPHRPIWVFDKLSRSTATPRRPDAPSRSPASPHRDRLPGSSRTGVVARTYDTRHPSRSRTTLSRMAYSNLSRGSEHGLFPSSRCSRARYLVSHISCKLRKPIHISHLKPALSTAGASCQLPPEFSGQSGFAAAVCCTVLPGWCRTHCGAQTICGQRQGGNWHPSPICQTGIIASGVKPWVSNGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4V1</accession>
    <name>A0A4Q9Q4V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17198" checksum="F53EDC18A10AE83B" modified="2019-07-31" version="1">MDARAYNVSVLYHLDRASCAAPPLKKHSHMVIGFYSTETEALSFALEDGADHGTHALMAILHEGTSMANDQPSYATSGCAQAAKVVPYGILWDLLLISITVVRTTQQYASGSGRHLVSLLPLFLLYALSTLRGQNGRHLCSLTICCTEHVSSLHDSNLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Y8</accession>
    <name>A0A4Q9Q4Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_872389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Y8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="52361" checksum="424EB4C12C0B43C4" modified="2019-07-31" version="1">MGTAWEGCELRLHELSIDAWKKALGTLPAEGLSPQEDQLKQHFEEGLKLAEQGLAAVKDRSMPDDRLFSVPNLSEKLPWMRALSMEGVLTANNVLNTCAWPLMNAYKDFSDGVKYMKQLKRTDTGAEGNLNALNLIVNGLLRDQRVFHMDSPDWIENLQLQVEFELAAFDGWPEGGPETIKEEAVKLLKEKGWKATRNALAATIRAWFLRAYFADRSGQSKPVAMQYYNSIVDVLEWGASTWHDVPTSDRGVIFLKTFIRAIKRIRMEAYLTALVEYEAGPENEKPEFSVEELIEMANSMVEETTSNPPKAGDGTPLDKGAWYSFHVFPIADAHATLGAIFMQQGLSAKQEGDAEEAESMLAAAAKFYKKAAEMYPPDDENFPFFLKIAFEADWHRGRPLSETLLLCDRIRKALPAVAKIWEFNPADKLQPHIHQLDEFETRAYTGLLEEKYTMNTPSSDILMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5G8</accession>
    <name>A0A4Q9Q5G8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1295-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5G8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36438" checksum="2AAB773915604EFE" modified="2019-07-31" version="1">MGSPVNVLDGDYLAITLLVTAGYQLTGFAIAWTFQFDKITDFTGGSNFFILALLTLLLGQEFHGRNILASVFVMVWAARLAGFLLFRVLKTGSDTRFDDIRSHFFKFFGFWIGQILWVWVVSLPVTILNSPKVSAGVAPGFGTASDILGIIIWAIGWAVETAADLQKFRYKSTNPPKEKPIDVGLWAWSRHPPYFGEILCWWGIWTLSIAPALGGTHNSGARSALLGSLVSPLFTMILLLFGSGVPTAEKPVAQRFYKMAYPEDDTLTGHDHGERKPTNAAWANYQAYRGQTSILIPLPPTIYRALPLWVKRTVLFDLPMYEWTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5K5</accession>
    <name>A0A4Q9Q5K5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter homolog 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_95974</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5K5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5K5"/>
    <dbReference type="OMA" id="YLQCSAF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="188"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="92"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU62380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="410" mass="44600" checksum="AB8BE4E80DBFB589" modified="2019-07-31" version="1">MSYLRLGLCVGGVYSMFLLWAIAQERLSVPFQHIDGTSSEKFNSPLFMGTCQSFLSALAALLYIYLRRKPGQTLHQILGLFDAPKTTTPNGAANGNASINGSANGHAKANGHTHTPHENKRDTRFDTRSLLLRYLQCAVLITSAAPFGFAALSYITYPAMVLGKSCKLVPVMIMNVLLYHRKFARHKYLVVAMVTLGITLFMGFGKEKPGKAKPGRGSAGAGQEGPSAYAQLIGITYLLINLLIDGATNSTQDEIFARYKVTGQQMMFWINVFCTALSAAISVLPLPYVPVLHPAASGTELGAALAFVRTHPSVVGPLAQFALTGALGQLFIFETLQHFGSLTLVTITLTRKLFTMLLSVVVYNHKLTPGQWLGAAVVFAGISVEAWVKRRDVHAKRVIQEKEKARIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5Z0</accession>
    <name>A0A4Q9Q5Z0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5Z0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5Z0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="259" mass="27871" checksum="F82E128B403AF54F" modified="2019-07-31" version="1">MSAKPLLVVAGIGNGSGTGAATARLFAKKGYRVALVARNADHLNRLAGEINNEGGEAAAFPVPDYSYSATLSVFDTISAHKWNSEGPSELRVGVWNAGSGVRKGFLDVTEEDIVESLQVNVTAAFAFSRGAILKFKENSLDARGKRGTLIFTGATASIRGNVTTSTFAAGKFGIRALSQSLAKEFGKQNIHVAHAIIDGAILTGQGLERRSGEEAERYKNDLDVRLDATSLANNYLNLVEQDRSAWTWELDFRPAHEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q627</accession>
    <name>A0A4Q9Q627_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_58477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q627"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16286" checksum="295F6EEA63F0C2F5" modified="2019-07-31" version="1">MGQSEKSVVPALCDTPALRTRTSLSKLNAALLGLSPNGCSSMNPTPWYRPRYSDGSSPPTSLKKSGSSKRTVGVGHVRVRGNGTRNLNRRLRGTETETPAILTSDAAILSRTDPSECRSSAFRLHLRPWSKRTCGHVQIRLASPLLPFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6J5</accession>
    <name>A0A4Q9Q6J5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_945518</name>
        <name evidence="1" type="ORF">BD311DRAFT_750195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6J5"/>
    <dbReference type="OMA" id="TNYQEMN"/>
    <dbReference type="OrthoDB" id="10052172at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU32525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7193" checksum="8B6942C8B58F7F41" modified="2019-07-31" version="1">MPGYQKGDQVEYRPIGGAEENVAHSTGVVEDVFENEDGQTRYAIKNDNTGKSTNYQEMNIVRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q763</accession>
    <name>A0A4Q9Q763_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative lipoate-protein ligase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_842089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein lipoylation via exogenous pathway; protein N(6)-(lipoyl)lysine from lipoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LplA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q763"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q763"/>
    <dbReference type="UniPathway" id="UPA00537">
        <property type="reaction ID" value="UER00595"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017118">
        <property type="term" value="F:lipoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16443">
        <property type="entry name" value="LplA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.50">
        <property type="entry name" value="CO dehydrogenase flavoprotein, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004562">
        <property type="entry name" value="LipoylTrfase_LipoateP_Ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00545">
        <property type="entry name" value="lipoyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561">
        <property type="entry name" value="LIPOATE-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12561:SF3">
        <property type="entry name" value="LIPOYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="5">
        <location>
            <begin position="58"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="41147" checksum="57C110200A87BC61" modified="2019-07-31" version="1">MITHFARTSFTRITCTSTALRCFASGSAPTPEHSIYISESTDPYFNLSFEDWLFRHKSPDKPLLLLYRDEPCVVIGRNQNPWKEVNLRASRQTGIPFIRRHSGGGTVYHDLGNTNFSIHLPRASFDRHATAQVVLKAVRSLGVDANVNDRNDICVGKDKVSGSAYKIVKDRAYHHGTMLISTKLDTLGELLRSGKDTMETRGVASVRSPVCDLQQRYGHVDHEKFVRAVIDAFRKEYDVHEEVQMVNDADGTQNIEYIKHGMKELKTWDWAFGQTPEFTYKIEHGFPWGVVSAEIRSKHGVILSCSVACSESTEEHLKERLAALVKRLQGQRYGSVDDGITLLAEEDERVTGVWEWLRTEMDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q795</accession>
    <name>A0A4Q9Q795_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_917152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q795"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q795"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040750">
        <property type="entry name" value="eIF3m_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18005">
        <property type="entry name" value="eIF3m_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="436" mass="47825" checksum="758C74699B52D0E9" modified="2019-07-31" version="1">MAATDSISIFAEGTFEEQILELVNYLARALPEEGRPAYIQPFQESLATPEGQKPLDEDEERRRQIFGTVLPEVKGLGDGSEKDIEGFFNLLFSHFLVLYPLDEPSTHSQLTTLLNTISASPDHTPVKYRILSNLFNALPRRSGLRLPIYQTLLELASVNDDIDVLGLSQSEVDKWLSEWEITPEEKSSFIKLIVGAYKKAEQPVASYQYQLSYVRSLPPSSPEAQSAAIDAVASALRLHNNFDFDPLFRLDAVVAAKDHELFALLQIFLNDGLAQYQQWASSHSDALSKYELDSSQLERKIRLLTLASLGFQNVGRDIPYSVIALALQVEPSQVESWVIDVIRAGLVSGKLSQTAQTLHVNRAAARAFEREQWELLEKRLQAWKTGLASVLETVSASRKKVGPSAAAAAPPEAVANGAAAPTGIETPAAAAQAAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8E0</accession>
    <name>A0A4Q9Q8E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8E0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15948" checksum="A9914BB81F63A6F2" modified="2019-07-31" version="1">MRCAGKSTGSKSHQHDVINFWAFLIFHLPTGLGQHCWLNVVLYSSGYYRNVEDKMLPRALCKSVCPAHRILEPEHARMRWLRLAVEELSPSEAPELLAHVDTSVTTRSVSSHPLCKGFVCPGIVPLTKHKPMHETTDHRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8U5</accession>
    <name>A0A4Q9Q8U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_964415</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8U5"/>
    <dbReference type="OMA" id="PGLWYAP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="584" mass="65046" checksum="0E8AE1F217E0CE10" modified="2019-07-31" version="1">MTLSPQAIASSWFNAFSAAFTVGDLDALAGLFLPDGWFRDLLVLTWDSRSLEGREKIKAFLSPTISGAQATDFKVEESSHLAPHTSFIPQIQTTDIEFGYTFKCSRGPGRGFVRLLADRDGDGEYRALTVMMMLSDLWGHEESPTLHLREDVAGVAGRNMQREFADWVKEVETKPYVLIVGAAQTGLHVAARFKQMGLPTLVIERTPRIGDVWRKRYLSLALHTPRKHHSLLYQPFPDNWPQYTPRDKIADWLEQYVAVQDLVVWTSAELEPRPKYDSEKREWDVTIIRDGKEYKVRPAHIIMATGTLGAPYIPDVAGKDVFDGRVLHATLYNDPEEFTGKRVVVIGAGNTAIDICQDLALTGVGSVTMVQRSSTCVMSRDFMTDVMKHVFPEDVPLPIADFRNAGMPYGLLRKLNIKAEGYMWETQKGLHEKLRKGGIHVNMGPDGSGLFFLTLGRLGGLWQDKGGADLIAAGKIKVKHGVEIDHLTKAGVVFTDGSELPADVVILATGYLQMKETNRALLGDDIVDRTGELYGLDEEGELKASYRQSGHPGLWYATGDFYQSRFMSKILGLQLQARQLGIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q933</accession>
    <name>A0A4Q9Q933_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N1221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_915157</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q933"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q933"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040185">
        <property type="entry name" value="Far11/STRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021819">
        <property type="entry name" value="Far11/STRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012486">
        <property type="entry name" value="Far11/STRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239:SF4">
        <property type="entry name" value="AT25231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13239">
        <property type="entry name" value="PROTEIN REQUIRED FOR HYPHAL ANASTOMOSIS HAM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11882">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07923">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01293">
        <property type="entry name" value="DUF3402"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01292">
        <property type="entry name" value="N1221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Far11/STRP N-terminal" evidence="2">
        <location>
            <begin position="26"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Far11/STRP C-terminal" evidence="3">
        <location>
            <begin position="411"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1052" mass="117683" checksum="7239C99421BE0175" modified="2019-07-31" version="1">MQGVGLDSITLGQLKAMVGSAPKPKQSYYDFRYDDEDHVLNEIEEFYSYVEMPQVAENLKAWEGSFPGEWTTSSFAQRKAHVQVLLESLEHRDAEIRFTNARRVFYVLQGTFAETTSPEDQLHWIIENCKVVRAANGLSNIIEAIKIASSKHDLLCSLSDADAAHFNISSQEKADFMEEVTTELSVYLGMLYHMVEVFKGHDDFADELMSLEPPLPVYLFNVVAGLRDKSAKGYPVKKLLLVLWKTILTCCGGIRELASVKKLTRELAGLSPVPEEAVPIKASPIDLEVFRQEISVKYPTFNPKPVTVLASAPVPTSKLAQAYSPIPVRHHYEHDGGDSQHQDQSHGSMSHTYNATQPGSSFRGMQPATPAPSPPPSPKPKKQQFQTDQNRPFLFPFSRTRVGYNDSRLVPFAIDEADKLYAKHMYVSLSLWQMWKTREECMTVESGLEYLPGAGRPSEPKVPPISPQQDDEGGESLPDVAILDAKIAEAEKAIAEGETVAEKRRAMERKEDLMRLKRVEQIYSAVLPVLSGWVLVLLKLLLATVSTANSTGPPHSATGTGYPPGVISPLEQAPPKPATLDETDVTRHREITSKAVSAILLLTLKWFKMSHVMKFHHLGQLLLDTNCLLLILKIFGLQEVSTAVVSKADAPEHNFFRYCQTHFARRSESGGVSDDQMQRASRQTIVRTTILPNGQKHEEEVDLLTDFSWRNFFSTINFAKIMQKLSKHRSHRIRMLVQYKSSAVLKRILKVQHPMLQLHVLKLIKSQVPFCGRKWRQSNMQVITAIYLNCRPDLRDEWLTGIEVDDVYDAQAQEQALRHLVKFYNNKRYGVQSTVQSNAHRRAASISHHLEGLHPGPELSGMLRPVQTPNTVDADVFPPLRAQTTEPSIFLPYVTEDIAFEEEYEEYLRWSENSDTSSQGSSAWSRLPELMHDIADGISDSESIVSIGELGDDARLDHTKEARDVPDENVNNWEHMSPKTMAALAKSPSAHGRRSSSGSGGLRPVLPLDLNSGTALDDTDDDEEELGPMPKEPSGPFQSGGSVDEVEYAYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAC2</accession>
    <name>A0A4Q9QAC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_587564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAC2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18118" checksum="36F35E42EBF0D2BC" modified="2019-07-31" version="1">MAELENILQEITNFLGCQAIDDSESKVHYPFGVIKITIRCSTVARDIEATCGNANSCLAIVYAKSRPEHKAKNVALCRVHEAQVLAPRSFRFLRLHTTKSRTCKWQHGHTALFGLCGERGTYSIPSLGSNRSECLSESVADASFAFRKRLMTASRITSTPGRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB28</accession>
    <name>A0A4Q9QB28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bis(5'-adenosyl)-triphosphatase</fullName>
            <ecNumber evidence="7">3.6.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_913550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>P(1),P(3)-bis(5'-adenosyl) triphosphate + H2O = AMP + ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13893"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.1.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.29" evidence="7"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB28"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047710">
        <property type="term" value="F:bis(5'-adenosyl)-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.428.10:FF:000011">
        <property type="entry name" value="Fragile histidine triad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051884">
        <property type="entry name" value="Bis(5'-adenosyl)-TPase_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46243:SF1">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="8">
        <location>
            <begin position="43"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="6">
        <location>
            <begin position="135"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for induction of apoptosis" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23505" checksum="A9F2AB4A40FC2563" modified="2019-07-31" version="1">MSPISDLVPVRVRRARPCPLPHPPLRSDDGTHQLAIKTSRIMSALFFSSFDVTRQAFYRSGLAAAIVNLKPIVPGHVLVIPTRVVPRFADLEQDELASLMASVQHVGRVIERVYGADGLTIACQDGKAAGQTVPHLHFHLLPRKIQGDAFARNDDVYPALERFEGGLVDNLRRVPQPLQVDADEDRKPRTLEDMEKEALWLKTFFDPVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE85</accession>
    <name>A0A4Q9QE85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_19246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="415" mass="45560" checksum="01E8E59780CCB9D2" modified="2019-07-31" version="1">MFEGLPQSCETRNPFIVLRFVLLGILAYINILTIGFAAWNLTVLRVLDVHVLGSPTFVLFNSCLLLTLLAFCFASSRFPVKFINQVRYECAWTGALSTLQLGGCVAVTANGPPVLCQGISIVACASSSLVVALSWISCMILILYSFSLLTTTVTHMHVVADIWMSSVCEVPWFVGPSTTLEYTPRVARTEKARHSDVLDIKRLSFHYPTPIFEQFAKPLPPSPQPGSAPPSPIWPHRQSIPDSLHAIPPVDRRSTWTSRLLTNTRPTSLAHKPSKESMRPSWAKRVSPRRGVDAPFAMPPMPRFSFRQPVLPPVRPLRPLKLKSCWSQTTVNSPPPVPALPQKAVVVGGPGLPSSSPTGSFYIDLERDAVVPVGDASRPVSYGMFPEDVGDPDQPVTRARLSQWVRAGSETSSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QER5</accession>
    <name>A0A4Q9QER5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_902455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QER5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU66235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="20074" checksum="1C62A757BDA81720" modified="2019-07-31" version="1">MASTACKALIPPVTPASPSTLRKKVAPAEKTGPAPGSSSKVRGKKQETSAEREERLEAERKKKEFERKEKEIDDATAPMEADLPFSRHARREIMVLKTLCYAMLEIRQFRKELEVLWREMCLTRGTISDLARSREGVYQEYFSGIADLLEGEPSDSEGHLELDPDWTEMEKFGVGSPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QGA3</accession>
    <name>A0A4Q9QGA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ClpP/crotonase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_802803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QGA3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QGA3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="276" mass="30550" checksum="374357C28327F03F" modified="2019-07-31" version="1">MSKVIIEVSQGIATITFDRPKSLNAIEREDYHAFAEALRAIDKRTDVIATIWQANGTWFSAGTSVKRTVDPSKIHTARDFFTDSIAVVNTDVSRALYTHSKILVAALNGPVMAFLGHFDFIYALPGAWLSVPFTFLGKSPFRMSPTEQPRIVAEAGSSVTFRNRMGAAKANEVLIFGKKKEAQELLECGFINKIFPEQPVPAFQAAVRKHVLSELDGLDPSAVLGVKSVIKAGFNDQHSLDTVNLRESYAQADRFETGIPLERFAKIARKEIKHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QGT5</accession>
    <name>A0A4Q9QGT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_783604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QGT5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU66174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13538" checksum="60D58282BB254936" modified="2019-07-31" version="1" fragment="single">IMVEVDEKEDHLMAGLDDWVVQPSLRPFLRARGVPSELYTHDTARSGDAYRLLFIKLTIAGEQTAIGISWHHTLGDATVLCRFIQYLSQCYQGGGSLPSPIPTFTKRDFAPPSESLLAEHAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6K3</accession>
    <name>A0A4V2K6K3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_226003</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145246">
        <property type="protein sequence ID" value="TBU52553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6K3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF173">
        <property type="entry name" value="MFS-MULTIDRUG-RESISTANCE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="382" mass="42109" checksum="FA6A99DCD5F76353" modified="2019-07-31" version="1">MGSISPAPESSGYESPLSEKQDKSEVSVPEDSDQDGVSDILIVKFSANDADDPRNWSGGYRWTFASSVPAGFASQLLVHFHLDAELVALTITLFVMGFCVGPILWGPLSEQYGRRAVLIPCYTLFTAFQVGAALSPNTAAIMTFRLLGGITSSAAHPIAPALIADVWEPSTREKALTYLGFLSFIGPTLGPLIGGYMAAGNLRWQWVFWMLTILAGTCTLLITCTQKETYRPIILARKAQRLRNETGDPRYRAPFELVQKSTIAATLYKTLAKPFVMFVHEPALIATTAYLSFIGGCLYMMFEAFPIVFEEGHHFKSSSLGLMYLPLTVGNIVALIFYLCVTQPDYERKAKRYAPNPVPPEERLTMAIWAAPLFAIALFWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6V0</accession>
    <name>A0A4V2K6V0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4470 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_887493</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145209">
        <property type="protein sequence ID" value="TBU53623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6V0"/>
    <dbReference type="STRING" id="114155.A0A4V2K6V0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="4"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4470" evidence="2">
        <location>
            <begin position="190"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="986" mass="111681" checksum="7AA3819E50B9BA4A" modified="2019-07-31" version="1">MGDAAGLKQQGNELFKAGNFVKAVELYSKAERADPRDPVYPSNLSAALYETGDYAGCVDAVLRSWDLLKDKDDAKPDLIRRLSMRLARSLCHGVRAGTITQDVLTKHKEDIMLLQEAAAECPTSAATGGEHAHVWEDWETVKLEIDDYAQKADTCLDKLSRLPLFCKPLDHAKEFFSMGHDQVIDLVHGWGPQDAYPLYLDRLPADQLSEVAFLFGGVGDGRHVLGTLSGLYEAYKKLPEAKRANCRAHLTLLDIHDGTMARNLCLLMLLDQLNRATDPIDRAEINATLMYMFCGAVMPSYCYDRQAHYTLVRLMAVIDTLRTRLTEHPPGQLAWLHVVSDTIPAVVAILDFWAKTTKSTRKMLAAHECLNPSEDPSMFDVSSIPGANPDFQKVINQNISAEREMFKQVLLNMPEEQLLKLPLPGAPEQGSLSAKRAFVREFADELADDFMKSFGGGRIPMYEESWYRIMKVFLPPPALCNRHPGFDESFSKDRKLEPIPPALERKIMKHVEAEWKANISLFDFNYAHPRYYPDGDGFPNLKLNVFEIVSAMDTFNRRNERESKKSVGVGKDGKKLLAWQVCDAFFGEAAAALKGLESCITLELICGGLSEELAKIHFKGDLTRPKDFPRKYTRMWLSNVPDYTHGPMNMILYVVPNLQEHPQAAVASNCLLNTGAWTNDAEFVHTYTLLLPDEVPRYLGCPIRVCQPVMGVLVLGSQPLPRPLSELATRDELTTWLTRTLFNTFLSGFSGTRPTQIRLPHNLVAFFGLLMYLHRVGFPGHWLSDFLARVLNGRMVSDVVPYRKKYPIPVTDRHRRTKARQVRTDPWLVEFESIIATAYYAIPFPVAGALPADFSRASQDIVVWEVRVQPPADFWHHPCMQYSTPDEPRTHLLFYRPDLVSYRKAIDEIEKIFEGDPSPAPGTFFVLTAQEHVQYDESIRFRLSKRRVDRMRNEKWNMVAYRNDSGQQASRPVPIQNWAMVGARSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9S9</accession>
    <name>A0A4V2K9S9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAMM1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_805136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MYG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9S9"/>
    <dbReference type="STRING" id="114155.A0A4V2K9S9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003226">
        <property type="entry name" value="MYG1_exonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215">
        <property type="entry name" value="METAL DEPENDENT HYDROLASE - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11215:SF1">
        <property type="entry name" value="MYG1 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03690">
        <property type="entry name" value="MYG1_exonuc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="38217" checksum="E86553449CFB547B" modified="2019-07-31" version="1">MSTGQEHPAKKQKLEAKAIGTHNGTFHCDEALAVFLLRKTNAYADAGLKRSRDPAILDTCDIVVDVGGVYDEKIQRFDHHQRGFTEVFGHGFDTKLSSAGLVYKHFGKEIIANTLQLPLQDPKIETLWLKLYREYIEAIDAIDNGINQYPTELKPKYRIRTDISARVGYLNPAWNQSTDSATVDAKFLQASALVGNEFLDRLGYYADAWLPARDLVVAALEKRKQVEQNGRIILFEQFAPWKEHLFELEEALQVPDAEKPIYVLYPDETGGNWRIQAVPVAPESFESRKALPEQWRGVRDDDLSKLSGVEGCIFVHASGFIGGNKTKEGVLRLANLALDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MJQ1</accession>
    <name>A0A4Q9MJQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_921004</name>
        <name evidence="4" type="ORF">BD311DRAFT_723786</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143429">
        <property type="protein sequence ID" value="TBU27719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MJQ1"/>
    <dbReference type="OMA" id="NFWEAPE"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU27719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="12194" checksum="F1E8C07569B6ACCB" modified="2019-07-31" version="1">MHPSLRLANQARQPLIRFLGKRQWPSKPEEQHPHPFAPQELKERFGEFVKKFQTAPAAAASGSGAAKKSSSSAKVFEEFWQAPSRFWKHDLEEWEIDLVQSGGATRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MYM9</accession>
    <name>A0A4Q9MYM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_979493</name>
        <name evidence="13" type="ORF">BD311DRAFT_775259</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MYM9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MYM9"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14127">
        <property type="entry name" value="STKc_CK1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000160">
        <property type="entry name" value="Casein kinase I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="331"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="463"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="484"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU32637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU55555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="60263" checksum="966C27A1D30F73EB" modified="2019-07-31" version="1">MTTPHVIASSSVHHSSQSATSNGVVGNHFRVGKKIGEGSFGVVFEGTNMLNNQPVAIKFEPRKSEAPQLRDEYRSYRTLNGTPGVPQVHYFGQEGLHNVLVIDLLGPNLEDLFDMCGRKFSIKTVCMAAKQMVTRVQSIHEKSLIYRDIKPDNFLIGVPGTKTANTIHIIDFGMAKHYRDPKTKVHIPYRERKSLSGTARYMSINTHLGREQSRRDDLESLGHVFMYFLRGGLPWQGLRAATNKQKYEKIGEKKQSTPIEELCEGFPEEFAIYMNYVRKLGFEETPDYDFLRELFTKVLKTLGEAEDGVFDWMLLNNGKGWEASHTSTLLASAHGGTPHTPHRDRHRERERAHRSSRNQLDNGAPSPSSPLVLAPTPAHVKSTSRRPHDASRGGSREQVSVQPLAPQSRRQSQQQVARAERDSGLIAPHPYAAPNSAGGYRTNAYGRQSPIPPNGAPAVNVSGALQQHPNNSESFMYGQGQGKNGTASREGTTTAGTRQEGMNGQTRAMGVYDREQMERVGEQDEHGMGRKKGFWAAFCCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N576</accession>
    <name>A0A4Q9N576_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Conidiation protein 6-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_805581</name>
        <name evidence="2" type="ORF">BD311DRAFT_649274</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N576"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU35138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="84" mass="9130" checksum="69A0C926CCE12470" modified="2019-07-31" version="1">MRFGGNGLAPPLTEASIANPNVSEEAKERAQERLQKLEDTGELRSREAHEDNVAIGHKANLSNPHTSQGAKEHSAQILDEMGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9ND25</accession>
    <name>A0A4Q9ND25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9ND25"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15601" checksum="1454800591580A78" modified="2019-07-31" version="1">MGFEGLWATRTLAPHKRPDKSQLARAEQASTDPLRERYGISNTLTYPQHGRSVDGHWEDTGKNVSSILRVIDERNLSVTTITVWVMSPRRLWVMGYWGPMGYGVEFPLSRLGKAKILWVFGVYGLPGVWVRRVSTVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDP2</accession>
    <name>A0A4Q9NDP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription initiation factor IID, 31kD subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_915488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDP2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NDP2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="128"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="173"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="264" mass="28282" checksum="142FE662E00F467B" modified="2019-07-31" version="1">MSRTAVADTIPPTARGIALLLASTPTVQDAQPGVLHQLLEFSNRYTAQVLSDALVYAEHAGRSGKVEMEDVVLAVQARVGWEFGGRVPKEYMLSLATQTNAVPLPSVPEVYGVRLPPAHECLTAVDFDLVPNKPPPGVKLYDEDVEEVEESESDEDEDMEPAPLPHPTSHLSQPQTQQQQQQHAHLPPVVGAAHTPSDVDMLTPGGAPPDEGSEVEEDDGLFAGGDEEEEESGDEAMEDVTASGAGEASTNGVKRKLVEEDDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFQ7</accession>
    <name>A0A4Q9NFQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_933254</name>
        <name evidence="1" type="ORF">BD311DRAFT_765484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143469">
        <property type="protein sequence ID" value="TBU24972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFQ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU24972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8030" checksum="D78525A34689ACD5" modified="2019-07-31" version="1">MCKEAAPRTPSGRCPQKLFLRSSFRRDAGIPVTVVHLVSAPCITSVAQSYLPSSTTRGHHWNVQSLSGRRQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGG5</accession>
    <name>A0A4Q9NGG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_827602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145184">
        <property type="protein sequence ID" value="TBU54659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGG5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NGG5"/>
    <dbReference type="OMA" id="QPQHQRW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20546">
        <property type="entry name" value="CYCLIN_SpCG1C_ScCTK2-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000111">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.6, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21797">
        <property type="entry name" value="CycT2-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="381" mass="42799" checksum="75164ECCC92BD7AD" modified="2019-07-31" version="1">MAIDYRGDPPSLIPANYFKYYLPYFTPQEVERLSEKQRGKLSVTQEEKARQQACGFIETVGSDIGFPRKTIATAQNLYHRFHLFFPRKDFAYHDVCLAALFVSCKIHDTLKKTRDVLVASYGARFPERAAKAKAMGGEIDIDPNVMEQDRQRLLAIERLVVETICFNFNARLPFPYVIKISRAFGATRKLAKLAYRLATDSFRTLVNLQYPPHVVALGCLYLAALLSSFERGTSPERPGHNTAHQIAATLSASGEWGRQFQAHIEDIEEIAHALIDLLIAAAQTPTANTSPRTPSSPSPHLSHSAGQQALPRPPPVPYKADQLIRLKIVMRETEHTPRNRESATRGEEDIMNFNKSDSTLLGRNDKTVRFMFGPPTMVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHW9</accession>
    <name>A0A4Q9NHW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_947352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHW9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="11075" checksum="1AEF7F8D3D1B1F0A" modified="2019-07-31" version="1">MADNLQSQNAIADAYYEYLGTIVSAICITLIIYDYVLTLDRERRYIWPRGLCGPSVLYYSLRYMPISYAIVLPYFLSPPEKSIEAYRSSIPSDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPD9</accession>
    <name>A0A4Q9NPD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_944178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9NPD9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1350" mass="144423" checksum="AF73AAE5CB9E9EE3" modified="2019-07-31" version="1">MDHRSTLSIPPKSDASLAEWTSKIKELQKQVDEDEEAETRRLEAEIAASRQARMRRSTNLGSRTNSVDLSQSTVAAAIRAEDQSVVSDEPLTALQKQRNQDDALRKLMGEDNSQRAPSRSRAPPYPKPVSPAPVLARRPSSPISLAAFIGGRATGPRLTKHAPQQDAHDPTQFEQRTHISAPHPIFGRGGVAMPGMTGNGKASVVSRAIREKEAESSSGSAAQRDRRTSTPTAAVSTIPLRSVAEKAQEREREIIPSYTGSSQANTIRQRTMSTPTGATPAKTSIPDETFNTKPKANPISRPLSHSPNPIIIRPITPRSSAGSRSPAPRPSSSASTYPASPSSPIPSSKQAVPLPGLARPIQPTPRHSLGSPQMPPSQNPSPAFLKPPPEKQPTPSLSRLQGRGFVKKVVEKSASLEVGSPESSPTPERSFTPSGKRQSSVLDRWQHGPGGSPTPPPVISPKPMPMRKSFTADPASPTTSSYSVPLKGDDSRPGLKSKSSMPSLPTMFTGSSIGASSSVSESGYSGPRLGSSKTVITFIQPSKTGDQPPSASPPSGPEVDELGMRVRTRTISGGLVQERGEAGLPVDAPKGQPLSHPTKDRAKKPRKGKSAPASALVSKLDSIRESSPTRNETVPLATAPHVADNERATPSLSPPQTYGPVRTVSPTSQGPAPPATKGSSDSSASKPIIPPKPSLDVDTRPVAGTPGETISVPTGPHAPPPGGRSPAITPPHSTAQKSPSSPARHSRIPSTGNRATVMDVAHAFTEALSREPSISPSPPSSVVERQAVSPPSSLGASHAAKEEEEEDYTPPSVRNMVANWGPRNTTTPPNNGTYGANNGAHGTNGSATQTIVAPPLEKRKSSYEKYSAFILPPLAEERTPVASPAGTLKSEAAPPPEAFAEDEEEWEPPAIGAQAPVEESRDELVAEASPAPEIVVVESVKPEPRAETIQLVHDDQPLPHVDVDALYRTSRPTHEPNSDVQTISVEVMAILGNSATAIGKDAHVFHDSELLAVIHRAKVKSSGLVTTKVWAWHGRRAQPDERELQKVQELARRYGTTPVPVEQAREPPEFVSVLGGTLATRQGTRAHWSPENTAMHVVRSLQGSIYIDELDLGVKNLCSGYSYCVSILETFYVWYGRGSTLAEQAAALAYAKTLAPSEENIIELPEDQSQDEEMFWMMLGDGDYANADYWKWRASAPCVDPRLWVVDDSQDDVIRSVSGFPAHAEFNRQVYLVDCIWELFVVIGSEARGRRLEIRLALSVADTLAKKASATRPFTPPVHALVFPTQIPTDLLLTFRELHESDLNAGDIPDHMNLVPAIEADANLNTTLWTSAALQDHTMLPLGVHPSDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR37</accession>
    <name>A0A4Q9NR37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_961453</name>
        <name evidence="6" type="ORF">BD311DRAFT_733654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143563">
        <property type="protein sequence ID" value="TBU21990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR37"/>
    <dbReference type="STRING" id="114155.A0A4Q9NR37"/>
    <dbReference type="OMA" id="CSGCWCD"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU21990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="252" mass="28092" checksum="E23E26A091A86D61" modified="2019-07-31" version="1">MPDGSFAHPQQRQFNPYTDNGGTILAIAGADFTVIAGDTRQSEGYSIQTRYAPKVFRLTDRAVLAVNGFAADGNMFVKKVKQRLEWYRHAHAKDMPLHAIARLIQTMLYAQRFFPYYVYNILGGIEEDGSGAVYSFDPVGSYEREACRAAGAAQSLVQPFLDNQIYFKNQKAAAGQSHPAHLPLSDVLAIVIDSFTSATERHIEVGDGLEIYVVVAKGRSPQGLETMRNVQELSTRPDGDRMFILRRELKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSN8</accession>
    <name>A0A4Q9NSN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_849205</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSN8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU59535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="531" mass="60376" checksum="E4C12B6A32B9946A" modified="2019-07-31" version="1">MTTNGAPVLYTCTLLTLLPSIWILIRLLKKMPPYPPGPKAFPIIGNVLDMPRRDFGGNFAKMRDIHGDVMYLNVLGQPILVLGTYKAAYELLDKRSVTLSGRPNSVMVELADMSWFFVFKNYGPKWRRYRRAFHQSFHADACVQHQSVQLEATRRMLCRILESSQDLSAILDFTFASTLMQLVYGLEVTRPDDRYFAMVERIREVSEDIAVPGRYLVEAIPFLRYLPAWLPGMQFKRYALKAKSDIHMILDSLHHASVKAKEEGCAQDTVATKILESSTSLEDLSHNETQTMCRGVSASAYIAGVETTNAVTHAFVLLMALHPEIQLRAQEELDAVVGQNRLPDFTDRPHLPFINALVKEVLRFHIVLPLGVPHRTTSGEVYNGYFIPEGTIVCPNVWAMSRDPDEYSDPLSFKPERFLDRVGESKFPERDPIDFAFGFGRRQVQLHSTYLICPGRHLADASLFITCASILHVYHIQPPIGEDGHRMKIEYEFSTESMLSHPKMYQFDIKPQSANAKRLILECMDAFLAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTI4</accession>
    <name>A0A4Q9NTI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_76290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145189">
        <property type="protein sequence ID" value="TBU54418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTI4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="41"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="289" mass="31966" checksum="C7AB792B60B3142E" modified="2019-07-31" version="1">MVSEDLRIDSVVTLPFYASAHAQPGQHLGPSLPRLGLGVYKNEDPKPAVLAALKHGYRHIDTARMYRNEQAVGQAVRESGVPRGQVFVTSKVDSKEHGSDVTPKAIEDSVQKLGLGHIDLLLIHSPLSGKEKRLEAWKAFIAARDKGQVHNIGVSNYGVKHLEEIREAGLETPSVNQLELHPFCQQKEIVEYCQKHGIVAEAYTPLIRGGWNDTIVDIGKKYNKDPAQVLVRWSLQRGFVPLPKSANPERVVSNAQVYDFELSTEDLKTLDSLDRGKEGSVTWNPVDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW54</accession>
    <name>A0A4Q9NW54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_925575</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW54"/>
    <dbReference type="STRING" id="114155.A0A4Q9NW54"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016216">
        <property type="entry name" value="Monophenol_mOase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000340">
        <property type="entry name" value="MPO_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU59240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="618" mass="68152" checksum="276CCC63E32F57C8" modified="2019-07-31" version="1">MSHFLITGARGGSTQGALAPNRLEINDFIKNEEMFSLYIQALGVMSKSTQEDLISFFQIGGIHGLPYISWDGAGQDDPAEQAGYCTHGSVLFPTWHRPYVALYEQVLQKHAQDIAATYTVDKARWEKAAADLRQPFWDWASNSVPPAEVISLARVTITTPDGKRTQVDNPLFQYAFHPIEPSFPEPYINWQTTFRHPTTLDADAQDNVAELKSTLRSAQTDIRSKTYNLLTRVHTWPAFSNHTRDDGGSSSNSLEAIHDGIHVDVGGDGHMADPSVAGFDPIFFLHHAQVDRLLSLWSALNPGVWVNKSVEEDGTFTIPDGATVDTNTPLTPFWREQSTFWTSAESVGVVPQKLQYSYPEFNGLDLGNQDAVKAHIAQVVNQLYGGASRGKRGFPPVVNFAATSREKEAPVHIESIAAAKPTSSVPVETPIPRAIAAQDDEDETQFTTEAIPSISIASNYWDWTARIHVKKYEVGGSFSVLLFLGAVPESPAEWRKSPHYVGAHQAFVNSSPQRCANCRRQGDLVIEGFVHLNEAIARLSGLHSFDPSVVKPYLHQNLHWRVQKAGGAEVPLNDLPSLELTVSATRMSHQPSEAFPVPEEPVYHHDVTHGRQGGARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZ09</accession>
    <name>A0A4Q9NZ09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZ09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="439" mass="48848" checksum="138F14D503B2170E" modified="2019-07-31" version="1">MSRRDTNPRTAPSESSLVAIRWKSRTACFDRTSVQTIVEKACGHCGLGSVQQDFVLTGNVDCLKCEVTDDMLKRLPRGAILTLSKITQECDSGDEDEGEHPDCSSSSMEANRGHNRGNHANSDAFKIFARTLTGKVLTFDGVRSETTVSEIKNKIRDKEGYPVDKQRLIFAGETLESSRVLSDYNIQRESTIRLLYSHKGGKPVIYLFSPHAISDATVSISLAPQWSFSHIYPQVDVKALAAGKEQASWSISANPNGSLVERGTGLELSYLFWEATSMIAIPPSPPSPRLDVPPPLVEHFDPAYPSLTPESPTAIIIPFSQLLMYLDHTLKALSLHTSARNDFITYWLPALSKKPYVALRFLPQDAYERAAELEVTPLPDVITRVFMLFRGVEAEEVELWSEAMEQVGKVDWVDIVGVKSGAWDERVFRVLEWGAMEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P600</accession>
    <name>A0A4Q9P600_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator complex subunit 16 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P600"/>
    <dbReference type="STRING" id="114155.A0A4Q9P600"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048339">
        <property type="entry name" value="Mediator_Med16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20719">
        <property type="entry name" value="Med16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mediator complex subunit 16 C-terminal" evidence="1">
        <location>
            <begin position="828"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="898" mass="98280" checksum="2169073CB5628FA0" modified="2019-07-31" version="1">MPPIHERNLSIAAKGKAKESVHWHLGWWDLIHSLEGTRRPVQWSKSSVIFTPHESRAYILARHFPTSRQFALPSPPIPLDNYEPATVISLCPTDDWLFAYFPGNGCPGMGCVWRKEAQLDNWSLRECWPYPVGGGVVTAAWTCHHREWVVSETGKSSRLPPLGPLAPYANPLLLLVTEAHLLHVYSLSPYTKTPPPTRAPLLQPIDPMHPPTDPESVGKIGGDRVCVKAAIGLCYQYPTILIAMRSALLPSQTSTQAFQSSMDLGLPVDLGQPQPSEAPFVQEWELWGEEPTISLCEVRIEYRPGVPPVLSRPLPPIHHPSSHLVELTFYCPPPSHAPNPPLSIAPKADPKGPQHPLYLAATFLDADDYTSIPKSEIISYTFVNGLPANFWGLKSETIRPSQTKVPCFLLPSSARGGFLAGFLDAGGLLPRRKSKSQETIIGSVEMLKPPDLSTHEDWESVPILSHAQHGAVDVPVSVALSPNEALVCCISSPLLGSHFAIQALPRRISGGSSSVLTGHLYGDLSRHLVAAIRAHYSPSDVVHALAMPMLPTEVTVNTLYHALTTMEADSYGLMDMWVGELLGVATEVYSARTQRLDRGPEQELCAARRQTAHEIASLSACCGAFDSCREGDSYDLDAVWQLLGMTGWIIEFVEKLFKECIFVGERPEATASTPTPREGVSTAGKSLDSPIFLHLVHPYALTRLKAAVEHVKRFHDHISRLPAKGEESHIAKDVLLDITEGIGVDLQLVGPLLAEIMQETKGLDAQNLRRSLASCCPVPALKPQIRKIVNKILPSKAIDRARLFIKPTELTDGVARLALSEPSAGAQSASLREKNTDVVKKSTLVRNKAASVCVRCGGRSDVAMGRKMGMESALSRWQAWEKNWQLRCVCGGLWSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6P0</accession>
    <name>A0A4Q9P6P0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="4">2.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Diphthamide biosynthesis protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Diphtheria toxin resistance protein 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_915161</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="4"/>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6P0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6P0"/>
    <dbReference type="OMA" id="WTPRHGM"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11850:FF:000006">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="394"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU63996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="564" mass="61560" checksum="05F5CBA48BDF84A6" modified="2019-07-31" version="1">MSDAEGPSSPPATKNATKPRKRFVGSKNATPSKLGYTPTVANQIPPDILNDAQLNAAIKKLPSNYSFEIHKTIHHVRKNKAKVVALQMPEGLQMFACTIADIIERFTSALTVIMGDVTYGACCIDDYTAVALGCDMLVHYGHSCLVPIDQTNIKTLYVFVEISIDASHLVQTIRLNFPNERQRFHQSLLDSEEQYARLPAGQQFVSGGHLRIEAPTPTEDSAAESGGAVPEFKHEAAPHELTRLALVSTIQFVSALSHLKDELSMECLDVDIPNLPAGLIEGPLDGSNDSGQVLGKPRLWTGKYDVSIPRSKPLSPGEILGCTAPQLNDVDALLYLGDGRFHLESIMIANPTVPAFRYDPYSKKFTRERYDHVEMRTVRDEAVQIARRSIAAYPHSQAPPESHLPSPPLTPEPTAASRSRSPTPYPSDGTPMWGVILGTLGRQGSFKQLRAITQQLAGAPTPIPYMPILLSELSPAKLALFSQHIAAFVQTSCPRLSIDWGYAFERPLLNPYETAVAVGKAVGWMAAGEGDAMERAKRGGTYLMDFYSAGSPWAVARTKATYQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6T1</accession>
    <name>A0A4Q9P6T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chondroitin AC/alginate lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1035478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6T1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6T1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38045:SF1">
        <property type="entry name" value="HEPARINASE II_III-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="Chondroitin AC/alginate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heparinase II/III-like C-terminal" evidence="2">
        <location>
            <begin position="524"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="788" mass="86181" checksum="62095B7CF8E21205" modified="2019-07-31" version="1">MASNYSYNPTYNHSNASNIHQASPYGSGDPYYNESTGFITPAKPKKGTSKWVKIGIPVAILVIAAAVVGVVLGIRAHNKSSSASSKSGSSGSNSASGAQNDIGIFATGTDSLYMLPLYPSTTNTALYTTPTFNAASKAKATWPSDPFQPASPSATQVRTDRPRLIAPAYKWAALPNMIANDPYLKSWNDTIFSNASTYYDLPVVQYFMDGDSGILDNAREVKMRVKAFSYVYRLTNDTKWVDRAFKELQNAAGNGTTPFGPDGTDKWNPTHFLDTAEFSAAFGYAYDWLYDILTDEQKSQIRTSLIYYGLGRGLVAYNNTDLRYTGWWSQNIYGNWNCVCNSGLTIGALAILGDDDTGTAEQILALTVDNANQNCALAVSPDGSWSETANYWYFGTTGHAEMAASLKTATGSDYGLLDVNPSFSLTGLFHMYITGPGSLFAWGDHGPNKFSTTANAMFLYGDHYNHPEYVLFQRDQHDAAEPWSMFWYDPTVSGAFWDGLALDHFFTNNTDQWASMRSSWTDENALYVGIKAGTLQGHQTHNDLDAGDFVLDAMGTRWAGELGSGDYRSTGYFSNDTQESDRWLYYRKRTEGQNTILVNQANQLVTAQPVILQNASSGTVQGSSTVLNLQKDDTALFTADLTSAYDSVTSFKRGVRLLNGRKQVLLQDDINASGTIMWRMHTNATVSVSGTSATLKIDDKTLIMSILNPPDGVTITTGPAKRFDNDPPLPAGMTDQDNPTVTVVMINLPAGTYSLQVLFNPQWDGMSSSDFVTPPSVPIDQWTLTSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8V6</accession>
    <name>A0A4Q9P8V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6589 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_835544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145435">
        <property type="protein sequence ID" value="TBU51030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8V6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046496">
        <property type="entry name" value="DUF6589"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20231">
        <property type="entry name" value="DUF6589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6589" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5846" checksum="226CAED37C82BDC8" modified="2019-07-31" version="1" fragment="single">QAIRMNILVNPTGQPHEFRAVDWVIELLNMLIKVFRPRPPVLRKLIVSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAT9</accession>
    <name>A0A4Q9PAT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_890623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145305">
        <property type="protein sequence ID" value="TBU51578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="26163" checksum="CC2BB647D4A08381" modified="2019-07-31" version="1">MFLNANSSRLPLLNPPTMRSLALPVEVIESVVDCCSEDTYTILAFTLTCRDLHPRSIRVLFTEVRLRNRDRLFALCDVLKARPERQPMVQSLSVMWERFAPFPLLSILPSLRHITFFRSGFRLGGVQCHQSTLLCCRRFGGGLRSLTIRHARFTSCTAFLRFLSAFPSIEDLTCERLIRVGTVEASPLVQKRLSRQLCLRTLNVSAVMVVSVWFLDGSSIFSSDRYFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB66</accession>
    <name>A0A4Q9PB66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">60Kd inner membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_953123</name>
        <name evidence="9" type="ORF">BD311DRAFT_776461</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143402">
        <property type="protein sequence ID" value="TBU30994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145290">
        <property type="protein sequence ID" value="TBU51728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB66"/>
    <dbReference type="STRING" id="114155.A0A4Q9PB66"/>
    <dbReference type="OMA" id="WWGSIAV"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20069">
        <property type="entry name" value="5TM_Oxa1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="8">
        <location>
            <begin position="12"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU30994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU51728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="259" mass="28999" checksum="A7AD89AC6E67FFC6" modified="2019-07-31" version="1">MELINVSTGLPWFWTIVATTVLSRVVLFPFSVKQMQGTAALAPHQAEILAIRDEMAAAQKKKDMLSMQRAALRQRMIYEKAGVSVVGMMIAPFVQLPVTLGMFFGVKTLCDLPLEQLKWSGFEWLPDLTAVDPTWTLPILATLLMNVQLSVTMRDLVGSTPQMGHIMNLLRLLTTGSVFLLANLSNGVIVYLITSITTMTAQSLLLRHPAIRRALRIPLVPEKLRTPPPTMRESAQYARQWWSDKMAEARAAERAAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBT9</accession>
    <name>A0A4Q9PBT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145318">
        <property type="protein sequence ID" value="TBU51465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBT9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14616" checksum="0B7199D922E9CDC6" modified="2019-07-31" version="1">MSSALIQGVVAGLLTLRTYALYNRSKKVLASLLLLLSVAVAITLWTIIGNRHAHRPQPTDALATSNGCDLTLSQQEGYSLALAWSTILIFDAVVFVLNVFQTVRTGWHWRGGYLRIMFRDGEIFHGHCFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBU9</accession>
    <name>A0A4Q9PBU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_789821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145262">
        <property type="protein sequence ID" value="TBU52199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBU9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="126" mass="14307" checksum="93DC6E564CC30670" modified="2019-07-31" version="1" fragment="single">LADNRFAEIQYFFGLKKMREDGGTDDVDMTLAMVSIFTPPDPAILRDTYGALIACRYAGDRSREVITVKDIVSVVAMLPLAPRREEAEDPRAAELYSNRFYVVERLGFDMSSIGREERMSDEDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBX0</accession>
    <name>A0A4Q9PBX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_246679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="100" mass="11209" checksum="A086B3B4EC9DBCD6" modified="2019-07-31" version="1">MNCTLTTDHVEQCARFGRTEAFPEISVSDPAPWLTRERAQGDEAVRTTTLYARAAAADLRMIWRTQTALDSEVAPNPSALPRDRLVHVSRAREPALRFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCU2</accession>
    <name>A0A4Q9PCU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_835478</name>
        <name evidence="1" type="ORF">BD311DRAFT_657241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143400">
        <property type="protein sequence ID" value="TBU31220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145426">
        <property type="protein sequence ID" value="TBU51047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCU2"/>
    <dbReference type="OrthoDB" id="3359487at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU31220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13339" checksum="51640887E77B7AD0" modified="2019-07-31" version="1">MHPAYKLSYFRKADWPEAWIQEACRLITHEWTTRYKPAPAANLTGPAPRPTRELFASISTRSALADHDALEAYLEAPPLATVKDPLAYWNAAIKSGSEDPALARMALDFLSIPGEFNPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCZ6</accession>
    <name>A0A4Q9PCZ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_941330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145277">
        <property type="protein sequence ID" value="TBU51915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCZ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCZ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.120.12:FF:000003">
        <property type="entry name" value="Dna-directed rna polymerases i and iii subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001514">
        <property type="entry name" value="DNA-dir_RNA_pol_30-40kDasu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00446">
        <property type="entry name" value="RNA_POL_D_30KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40438" checksum="F10E2B1383C9F85B" modified="2019-07-31" version="1">MASSSSSHLPQSVFNPRRHVGVHAERVSDVSSTEFPGHYPGEDHSWNLAKFKQNLKVSVKRLSQRSVEFDLVGVDAAIANAFRRILIAEVPTIAIEDVFVFNNTSVIHDEILAQRIGLIPLNVDPRLFDFRPPGGIPMDRNTLVFKLNVTCERAKKGSSSPYINEYVKSGDLVWEPQGEQATVFASRPPAATNPDIVLAKLRPGQVIEMELHAIKGVGKEHAKWSPVATATYRLHPLVLLNPSKPVPPEHAQKFAKCFSPGVVEVSAAGEVSINERYLRTETMSREALRHKEFEGCVELKRIRDWFIFQVESEGPYTPESLLPESIKVMRGKIASIRAAAEALLEDSQHLGGGVGPDADGDVNMGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD17</accession>
    <name>A0A4Q9PD17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_939609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145239">
        <property type="protein sequence ID" value="TBU52734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD17"/>
    <dbReference type="STRING" id="114155.A0A4Q9PD17"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="183"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="35213" checksum="B22B0341F54908D0" modified="2019-07-31" version="1">MASPSSGVPGGAIAAFLSQIPPLSVTYGAILIGSMFGFILYGLILHQSYRYFRIYTTDPLYIRLMVILVLLLETTHVAVTAHICCSHLVSAYFNPLSLLVGGWSLDILPFLSGITIIVSQIFSIRRVSLIGPMQSFLAWVVSLLLLGELGFGLAASIKAFIFVDVRVLKTATYLSAAGLGMVCVADTVLTVALVLAIRKSRVGHDRRKTGEWIFDLVQLYLINTGALTDVIDWIAFICAVARPTYLLLAALTIVASRLYGTTLLSVLNSRQLRGMELFAGSSMAISIARAKREASKDLWNTPKLPDATPPKIDIEVTTEMEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PED1</accession>
    <name>A0A4Q9PED1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_888035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PED1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="404" mass="45550" checksum="6A64F996FCE3F09D" modified="2019-07-31" version="1">MQRLTSRALLCRALSSWSIPCLQHCGRQYPPQLEASQTFPNSPYVRQLTTRSHETNRGSLRLGSLKPPQTRHREVYTLDPTRLTAHDYVDLSITLLPRVHFVSQSEGPSSAPSSPIRNSGILLYPRGLHDKTFPPNTSGFLYYHIPPYSPPIAGEVRFRVTPDADPASFAVGSDLLTEHGLPWRIPLLYTTIGDNYKGLHALLLQDGLVTQKLLETATAAAETIRNTDYRRHNTVGGHQTTILSSFRQKFIFRFGSYNGMFLVLGKDSIMRKHSRHIGEFYLPENVPRQYSPFKGSAICCFEPSPLPEHAGKRAVVLRILRPVDNDPIRPNEPSRGPTPVPHAALTPRNGQLLLTIRRRRIQPWSVYVDDVGKSEGDTKKSMGRMLRTLYENSELYGLPPEPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEI7</accession>
    <name>A0A4Q9PEI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High affinity methionine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_938311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145218">
        <property type="protein sequence ID" value="TBU53289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEI7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEI7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF382">
        <property type="entry name" value="LOW-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="559" mass="60519" checksum="4F52FED2BDF6C0F3" modified="2019-07-31" version="1">MPSLWKFPPTFKGRKSSENVEAAIFDEQVDVKVEKSASDCDVQELGADSVAEADTEVNPAGLSLEEDAAGGMGRHLGIFSCTLLIVGRIIGTAVFSTPSTILGSVGSVGASLMLWVLGFIMSFCGLFIWLEFGMMFPRSGGEKVYLEAVYKKPKYLATVLFAANAILLGFTASSCIVFAQNILEAAGRTADRWVTRGISIGVIVFVTVLQGLFPKLGLWVMNGVTVFKIVILLFIVVSGWAVLAGNTSVTDPQANFRNVFAGSSHSSNDYATAMFKVLNAYNGWSNVNYVLNNVKDPIRTLKIAGPLGLGISTILLLLANVAYFAAATKEEIINTGVTVASLFFHNVFGAEAQKALTVFVALSSTKIVFTVSFAAARINQELAKDGIPLPFGNKFWASNWPTGKSPLPGLLVHMIPSIIIILGPPPAVAYPFIIDVEGYPQQIINSAVVIGLFWLRYHKPDLPRPFKVWLPFAAFFLVASIFLIIAPFLRPTNGIGDTPPLPYYLYCLVGIGVLALGVLYWTVWRIVPGWLGYQLVPRKEKLSDGTVVAVFALKKEKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF82</accession>
    <name>A0A4Q9PF82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_787854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145301">
        <property type="protein sequence ID" value="TBU51621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF82"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17603" checksum="F595A1C0E54D08D5" modified="2019-07-31" version="1" fragment="single">DFEVAGPLGRCKICNTPGQGQWSRLGNLREHEKGKPHRQNLERKLRVAREVLTGASHDLVPPTTLPSPFAEDGAPDPDCLQHDWFPLDLLQDITATGPEGMDNKRARRVKRAMESALAGRISFTAGEESLPGGRDSELSMEDVLAGAGLLRAVLQPEDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFM2</accession>
    <name>A0A4Q9PFM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_833714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145291">
        <property type="protein sequence ID" value="TBU51721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFM2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="513" mass="58617" checksum="EEF8E97D4F7BBFD2" modified="2019-07-31" version="1">MPELDILHGWEYNVTQAQEQSIKTFGVPLRGELFKSALLPGFLTDLHAGYLEIWPRTFAMGTKEKPWWISCVVQDLRCGGGDSIGVADPLFAPHPHDLRRCTGKGAVWKPYTESRLETGDVCYVARGKEWAMAAGENLVKVHFGLEGNMVCVRREDYERIIMNDCPGSNKSKAKAEKMRSFTIPDDLTVPYARDKRAPQTIVIMGAIVCDHVAFLFVDFSRMIRFDIYRLDRAWTQADLTPESQFWSIIWDAGHGPDWIHETSAAELKLDKWRREVLTNADFSAEQGLVEVIVSRQDIFNGYGRHTAHDLLFYFGVWPGTPPSIICADDEIFHRFKVLLGTYARQFVEDKYRGACLGTANSRSPFAFNYKSDVNYLNQYVKVYRKWEVNITPAQYNELYMDGLLDPNHTIGEPYNYDESKLLSIDRKFTKLTVLMHNPGTRERWYTVIQAKRPKSWKFALSGPGKIAEDVRHAGMKTTLGPASFYNSKQNQFDPALLSGKRGRPKKVNHSKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGA3</accession>
    <name>A0A4Q9PGA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CAP Gly-rich domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_345334</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TBCB family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145319">
        <property type="protein sequence ID" value="TBU51456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGA3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGA3"/>
    <dbReference type="OMA" id="DQYEQRT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035371">
        <property type="term" value="C:microtubule plus-end"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043014">
        <property type="term" value="F:alpha-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01789">
        <property type="entry name" value="Ubl_TBCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.190:FF:000013">
        <property type="entry name" value="Tubulin-folding cofactor B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045172">
        <property type="entry name" value="TBCB_Ubl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF85">
        <property type="entry name" value="TUBULIN-FOLDING COFACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="5">
        <location>
            <begin position="170"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU51456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="234" mass="26418" checksum="EE5B5D56C8EF1A5F" modified="2019-07-31" version="1">MTSPVHVFVVSPDTRSERRYELSLTVGQLKNKLELITGIPPHNQSISVLASEDATEPLAVLSDDNRPLGFYGVQDWQTLKVTDLDPTTSFTGQLTDTSQVDKFELSETEYAQRQDTVLAYKQRNKIGRFSDRKSEEPVETQNVDIPVGARCEVETSVEDFKKRGTVRYVGPTEFAKGIWVGVEYDEPLGKNDGSVQGKRYFECQPNFGVFVKPERVKVGDFPVEEINFDDDEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGN8</accession>
    <name>A0A4Q9PGN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_226808</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145247">
        <property type="protein sequence ID" value="TBU52527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGN8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGN8"/>
    <dbReference type="OMA" id="MPLREFK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001423">
        <property type="entry name" value="Ras family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24761" checksum="F52E3FF87C5BD8A9" modified="2019-07-31" version="1">MARSGQSSFTRTGSLTKKSSSPARHRVAGLAGGPVQRYSAVVLGAGGVGKSALVMRYGKNVFLEQYDPTIEEEYDLTVEYEGKRSFLHLVDTAGTEQFTGINESYIQRGVGFVLVFSLTQEATLKEVDHIRQQIHRIKGGDENVPMVVVGTKLDLMGEREVSSEKMQELAMKWGVPFYETSAKKGWHVNEAFDHLLASMRKRYPEGDPKSKRRRRDQCVIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGZ4</accession>
    <name>A0A4Q9PGZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="16">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD310DRAFT_833320</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16 18">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="16"/>
    <dbReference type="EMBL" id="ML145277">
        <property type="protein sequence ID" value="TBU51906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGZ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 16 18" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="20">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU51906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="38743" checksum="87746D6E4F6030A4" modified="2019-07-31" version="1">MVNQSDLPFRILVRQYDASLVYTQMLLPERLLNDTEYLEFHRRGLHDTPDAPVVVQLCGNDPEVVVRAARTVVDKADAIDLNLGCPQDAAGEGHYGGYLLEKKDWPLVESIVSALSHSLPVPVSTKIRLCQNTALTSDLGVRLEAAGSSWITLHARHVSARRRRQGAADLEQVRVLKETVGVPVVSNGNVRTWEDVQANRKMTGADGVMVGETLLANPCLFANVTPDPVKISLEYLEVCREHPGTATMQTIQTHVRHFVDHHCSRRSWFNKFRAALGRCDTIDAIEKLLRVKVQRWRGLPPLSDGDIDDLEEGTTDEDGGGPEARDVIARYGENAASSGDVDEALAGLSILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI73</accession>
    <name>A0A4Q9PI73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1042143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI73"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="178"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="37089" checksum="233D753E57AC8823" modified="2019-07-31" version="1">MSSNATSTVLTSLPSLPSLNNTFGAVLIGTFLGLILYGVTVQQTTTYFRVYTADAFLMKFMIFCLALLDAGNAVVTIHVCYYYLVTNYFNPFALLDGVWSIRMLPILMTTTLVIAQLFYIRRVYLLGSGYRYVAIVAAICTIGAVGFGTVFSVECFKRTTFFEFNKFTWIGSGAFGCAVAADALLTTALIIFLRCRSTSFQRTKSMLSVLIVYTINTGLFTSALNLLTLVTAALHMNNMIYIAATILAMRSYVIAVLTVVNSRRSLIGSAREESDFGTFGLGASQKHSVRIPARLEHFRAPRSEGEVIGISSWKAPADAGVKHATQSQDGDDVISREDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJD7</accession>
    <name>A0A4Q9PJD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_936546</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJD7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJD7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="63033" checksum="0F663A97B6422A90" modified="2019-07-31" version="1">MSSPNKLIRLLKKNSHRVTNFGSAPHRALSDHDVLCVLFENNCVQNQGILTSADLRNCALVCRAFSEPVLRAMWQTMPSPAALWWLLVPEDKQITPWIPTKDLCEQVLNAEQWHIPERWFRFLWYARFVRKLQIPDYDLEAPNHARLLRTVLDDDHGQAVFPSLQVLWYSPTASTDTCFYSLLTPRLRKLRLSYSRALDTTLPLRLPSDPDFESIINELRRSAPGLQHLRIEPYYMSFKPRFIQQIATFEHLRGVKLMTSIPSTSFRILAAIPGLEKLHVSHFSWNEASDPCRTMYTPNLVSILVCGDSTSLTELFRALRAPMLEHANICMAREDAPAAEPDIVACLDTFVQAISPKQLRSLSLHVGRHEPATGIPLFDFLCPLFALSKLTRVELLGPNLPTIVDDRDFATIALAWRELEAFAMPAMSWERGQDTPTPVALDYFRRYCPHLRSLKLPFLDPCEEYIDYPPPPPDGSYHGLHELVIGSAAFRECVEDLGISEVEALATYVLNLFPEVHAGCKPDWDLRSEPTWARVLLRARALREVRDLNRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJV9</accession>
    <name>A0A4Q9PJV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_78729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJV9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="174" mass="19404" checksum="25C675A61D688CC0" modified="2019-07-31" version="1">MYLLSCSQCTVVLASRLSLIGADLFVLCVTWYKTRETVRISRTHMHRKTSITFAGCLLRDGTIYFLTLLTLSVLHVAFTLTSVAEHGFYDTTSIIVQLEEPLTSVLTARFLIDLQKVKKRLGDPSLSMSSISDLAAQPSLSRDINDFVTAFGGQIAFYEEDGEQVEESNLARLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKX8</accession>
    <name>A0A4Q9PKX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_934962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKX8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9225" checksum="C71CD3FCF3768D1A" modified="2019-07-31" version="1">MGLMSPRTEREGPSRCSTRYRIPFPAGGVEGVCVSDPIPFLFWLVGFGHVSLVALACARTVRHTRLVRTLGGDAVQQLGLSISTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM95</accession>
    <name>A0A4Q9PM95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_689351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM95"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20988" checksum="C5F3EE5D5EE311C6" modified="2019-07-31" version="1">MLWSLVATPDQYAPRYSQRPTSQQRISHRRLTTHSQQPYHSTTFTGGTSRSSRLLRGAESSRRHKTDIRRAILIHDLLPPPTRPKRPARIFARHTRTRQGALTASPDRAAGGEPVDVSAIDRDPRARPLALQHHPPRQQLRTPTPTDPSVRHSAAASQGRRPYPRSLAAPCPPATHSRGAAPCSDGGARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN46</accession>
    <name>A0A4Q9PN46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_933086</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14372" checksum="19E61EA2FD9F72C4" modified="2019-07-31" version="1">MHPSIHAICFLVWLLALASEVCAQQTTSSESGARSEATRWYGIERQQSYLGASKGLHRQCPLGWAPCSSTACYPLNGAQCCSNGKFCSAGSVCHVEKDGAVDCLKEERQDGTTASQGSVASIARWVSESLRVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNB4</accession>
    <name>A0A4Q9PNB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_856152</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNB4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNB4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="391"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="589" mass="64475" checksum="D3F862618AC2EA12" modified="2019-07-31" version="1">MISIGGVIGTGLFLGCSEALRSGGPIGSFLGYSLVGSVVYCLCVSIGEMIAFLPNVGGVVGLADLYVDPALGFSLGWASWYNWAIALPTEIVAAAVIIGFWDADSQAHVAIFSAIFLAWATVINCFPTRVYGQMEYYLSFLKFITIILIVVLGLAIDLGASPQGRLGFRYWKERPFPDNYLGTTGTSGHFLGFWAVIMQASFSFSGSEVPGIAAGEVIDATRNVPRALRKVWIRITLFYLGGVLVSGLLVPYDDPFLALGESPGHQNGHASPFVIAFTRAGWKLMPNVVNAAILLSALSAASSDIYISSRFLFFLARRKHAPSFLDHLVRYPRARVPRTQPKHGELSTESDSDSNEATDGDIGDQNLGLEEPALVPDQIAGEQVLPSAQAKWVMPLPCVLVCSLVGLLTFLGYGTGSANKVFVWLVNAAAVASIQSWAGMLYTYIRWHKGTVHYEIQYKGRDIHEAQEALAQIERIKKNRSPFQPYLAWYALILCVFVILTNGMTVFIHHEWKIAVASDQNKKVSGPDEGFGDAVSQFLAAYVPLPFFLVMTFGYKLVWQTEMIPYDKMTFDGGHIPPRTRKKNRQKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNG0</accession>
    <name>A0A4Q9PNG0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_883675</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNG0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNG0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU55811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="496" mass="55774" checksum="E38E28D05C131F63" modified="2019-07-31" version="1">MGSAPSKATQATPEGQSHDSEKGLLQSFSDVRISAPLSKDGALQLGHVDHWEDVVAQSPKLQLSRSILNHTDIRETLVKREARVADAHVFNLELDFKTNPITSQKSSGRCWLFATTNVLRYNVMKKLNLEEFQLSQSYLFFWDKLNKANYYLELSIENADLPVDDRLVQYLAKELISDGGQWDMAVNLLETYGIVPQPVYPESLHSSLSSPLNTILKTKLREHALILRALKASLRSNSAISDAALLAALRAKKEELLKEVYVVMSATLGAVPKPDEAFTWDYYDKSGKAGSWTGTPKEFYNAFAYDKYSPAESFSLIHDPRNDYGKLYTVDKLGNLWGARPVLYVNTQIDNLKQAVVRQLKAGHPVFFGCDVGQFSDRQLGIMDQALFTYEAAFDISFGLSKADRLRTQESSMTHAMVISGVHLDKEGNPVRYKVENSWGPDVGDKGYFVMSDRWFEQWVYQVVIPKQLAPKDLVKVFEGEERVVLPAWDPMGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNY8</accession>
    <name>A0A4Q9PNY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_824729</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU56010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNY8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="260" mass="29030" checksum="865C13DD91EDF9C7" modified="2019-07-31" version="1">MIPVPFVYNPSDDGTDENLLILLHGLGDTQVPFGKLGRQLHLPQTATLALRAPEQIPFLYEQAFQWYTSFDPLGELIDRPNPTPALDLMSKVVEHLTKDCRWPPHRIHLFGFAQGGSVAAEFALKYWRSELSLHQKSLPSFDANSGSDANEHAPRAFGSIVSVSGPLLSYPTLSRPCPTPFLILHRPPPAESALAPDAVTALRKGFTKVEEVKMKGEGMPRSKEEFEPIMRFWSEHLGRRQIEGLYEVMSGMAVPPHEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQD7</accession>
    <name>A0A4Q9PQD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_606945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQD7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19647" checksum="35B4B2D7F66A8624" modified="2019-07-31" version="1">MNWWERARGGRREASVGGGLCPRPASFPPSCCRLLFDVPRCRSLPNSSLWHAPLGQTCTQPRVSPIILSARKSLYQCQIATSSHVFSLSAVRRSITRRPSPPDPTAPSAAVLYDLTTTRYVRPSFLRPKHHPNVLLSQHPFSAPSATHCYCARCILKTVRISFDVAFRVVQGLHSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRF8</accession>
    <name>A0A4Q9PRF8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_788862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRF8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRF8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="23759" checksum="987168BC8F6167EC" modified="2019-07-31" version="1" fragment="single">LLEITDSRTVMGGVLEWKQKHEDQGYIMQKNAHLARALIAALRNRKARTAFKWVKGHRGHPLNEKADRLAGEAVAREIPDDLAISTPPNLRLSGAKLSCMTQKLAYRAIRSIKEKSLPRRKRTEKNLENIEAKIREGFGIYPTNQMIWKGLRSRHITYTVRYFLWMAIHDGYMIGDQWMRPNMSAELQERATCNKCGSTESMEHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRY1</accession>
    <name>A0A4Q9PRY1_9APHY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_978372</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13318" checksum="03AE78061CA91C60" modified="2019-07-31" version="1">MIAREAQNRNFPSHPYVTVAGSSALTSPAPVRKLVENRVGDELFNRQAKPLEHPRMAEALLIRRALAIPGDTRPILAILFSYKLAFLFRTLFTAAASAAALVVYARFSNPSSPSNLPDRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSR6</accession>
    <name>A0A4Q9PSR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_949396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PSR6"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="149"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU57394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="26530" checksum="CA98E860C400FF48" modified="2019-07-31" version="1">MAASLARLTSLSTQTLSLLLERQRLQNIPSNSTSLHTPQIVKNLSQLRAGILELEEKEGVSEATKLLRTQHERMRGMLGGDADTGDPADRRCEEPQTETMSSNASSSSIPTPATPPPAPPTSTEGHRYAPYTDDPEAGYTDEDMLLQQRLIMDDQDVHLDELSRSITRQRDLSLQINDELDVHTGLLEGLDHDLDRTDSRLTGARRRLDRVAKGAKENGSTVMIALLILVLLILIIVFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSZ1</accession>
    <name>A0A4Q9PSZ1_9APHY</name>
    <protein>
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            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSZ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020384996" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13675" checksum="27A91D3DD5599B93" modified="2019-07-31" version="1">MSGVIQAFILSCFRLSTLCAAQRNLSRASVHSRLSPHANSSIGDHKIPAKTRLDSAAACSNPTCCPRTLLPISRALASPQFPAPAVPTSRHILRTSPEISRYLSLATRETYLPHPVNERTGLPHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTJ1</accession>
    <name>A0A4Q9PTJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_534498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTJ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19109" checksum="C0184B589E11B9FD" modified="2019-07-31" version="1">MSPVENSGYYSPRRLTLSARSLVSPVRIRVSSAGSRPYRGIAMSAKRCLNLLRVTSVSTLISMGQRTHGNRREAGRYCQHIGSLCDPVDCPVSMMISQPPLNDLLCIPVSRTGMDMNFSAMRYGDIIWTTIWRYHMRNMTPSPVTIIGAEGMVLRVAHIYTTVCNTTLSVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTL7</accession>
    <name>A0A4Q9PTL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_880051</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTL7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043994520" evidence="2">
        <location>
            <begin position="18"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="415" mass="45243" checksum="2304D4367F7E0739" modified="2019-07-31" version="1">MLYTHLVILLLFCLLEPEDPLTHPPFFGMPTRQFPEDVIQSLSRLIFACVLPGHTTLQLCDPESGDICDYQLVKYSPAQVSEEILPSSALNKISLSLAMLDDLVDGLQSAIRNNCDTADFDSVRPIGRTQTPAKTISTVAHLSDSLFTSDDLDTSRPLSELCRTMFYSDPSKGQCAISPLPPISPTPHRYGSTLWLNDESTPSDADPSTTSITGTIATIDEERDEVEDSWSTYESADAFLDCSPVSAMLEISSSALCGLAHLPSDSDIFAPDHGTSSSGNDRQSNFSARGSTGSASSSDSSFGSLRVNAFVSSFKHPSDFRIIHSPNPAATSTPMRTAMRRALAVMVMHRDSPQARPPAAQPRERSRDASSPLSRSELISLPPQKAAERIMATVKAREEERTRAWAAMEERSRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTP9</accession>
    <name>A0A4Q9PTP9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">RuvB-like helicase</fullName>
            <ecNumber evidence="16">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_880035</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="function">
        <text evidence="14">DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="16"/>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTP9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTP9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 16 19" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="18">
        <location>
            <begin position="80"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU57799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="473" mass="50731" checksum="B22FD5C5EBBA5456" modified="2019-07-31" version="1">MKVSSAGSSSSAPVAHNAVPPPPTAAATRSSRIAPHSHIKGLGLNPEGFAIPDSAGFVGQSSAREACGVVVDLVKSRKFSGRALLLVGPPGTGKTALALAIAQELGAKVPFCPMVGSEVYSTEVKKTEVLAEAFRRAIGLRIKETKEVYEGEVTELTPTESENPLSGYGKTVSHVVVGLKTVRGTKQLRLDPSIYEAILKEKIQVGDVIYVEANTGAVKRVGRSDAYASSYDLESETYVPLPKGDVHKRKELVQDVTLGDLDAANARPQGGQDIMSVMGSLVKSGRTEITEKLRREVNRVVKGYVDQGVAEVVPGVVFIDEVHMLDIECFTYLNSLLESQMAPTVIFATNRGKALVRGTTDIYSPHGIPLDMLDRCLIVRTEPYNKEAISKVLQLRANIEGLKLGDGVLDRLATRGADSSLRYALQLLTPASILASIAGRKEIQLEDIDEMGELFLDSKTSSSIIRQHQGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUB5</accession>
    <name>A0A4Q9PUB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_906727</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUB5"/>
    <dbReference type="OMA" id="WYGNETT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044270340" evidence="2">
        <location>
            <begin position="21"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="22775" checksum="33C6B8ADE05A71B9" modified="2019-07-31" version="1">MYAKAFALLALSALSLSAQAAPAASSSPSNSGSASSSASVTASATETPVTLPIPTQLGFPTSVVTLSYAVDWVNVHADGIASYIGSSALQGVQATLGVMDAQKSIGTATHLTAFIATDANSAPVVMVSSIGGSAITLATGTVGGTTTFGGQAFRTAAPIVLDAQSSSSASSSAASSTDSANSSSNSASSSTSGSNTTSSASSTGTGKNNGGSAGVRVPQSAVVGALAVLGSVAMGAVAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUI9</accession>
    <name>A0A4Q9PUI9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_927739</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUI9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="146" mass="15351" checksum="89987974E6D348A2" modified="2019-07-31" version="1">MWQTGVAVTLIPPFNLPPSPRCSHIMSTPHLHDSSSQNGAVARSASRSSLDADIALMNKLLSEDVDESDPSIEELLKRLEAAEGLADGVEERLDVVIGSLDELLNDLEATQGEDGKGAESQKDGVQVGAMAKTNSSAVGRETAGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVG2</accession>
    <name>A0A4Q9PVG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_485627</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVG2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="142" mass="16284" checksum="1B677592DD2B199B" modified="2019-07-31" version="1">MVQCWAILAIVYGCARIPSILRRREVNPLSIYVHTTKNRPWRTSCLSDQRDLITVCITVALEVSQGSIRRRYQKVLKGCSAVHPHLEREMPCPLTQTYIVLECVVPIATDIWTWGKRRLSTWQIGKTWRCAYLGLMGGRRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW85</accession>
    <name>A0A4Q9PW85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1038894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020860012" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="166" mass="17604" checksum="51094AE5961B87C4" modified="2019-07-31" version="1">MRFLTGTFTTLALLASAFSPANAAPSQGAHGVTVRPADGETVVAGAPFPFEYAPANACHDGYTPIGVYIGREAPSFEKDVQDNGHLRPGSFIFQFGDWLIPNFGLPPSQPPPPPPAIFLPEFPNVANNTKLYFTVVETSINCPPGPPAVSPKYGLETTSVVYVTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWC7</accession>
    <name>A0A4Q9PWC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_948374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWC7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="326" mass="34454" checksum="6D7AAAB8CCC3AF30" modified="2019-07-31" version="1">MHPSQVDIRTFYSYTRNEAQASLRKKLATELDITPRGVQVRPSPSRPLGVPSADQQIDVLHPPFFNATSESACHMPIALSSVRLSTVRDVSAGSAASSIGPSSGAGIPQAAQRLSVDLAHLIMNAQGRPLSILSSGSSLRPLSTLLGISVDSTGCSARSLSSSVVSPREQAVVRVPPAHAHLRDLPRGAASLADHPMVRIEEATADGHSPPTDNEKLCSHCLTLRRTTSLINYLDLEATPGSMTGTPLNLTPWQHTSQESPLRRRATLQRGSPLKGELPRGAPHAQCTLTPSPADAGPVFQPPSPAKAEAKTSLLTSKLGLRSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX24</accession>
    <name>A0A4Q9PX24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX24"/>
    <dbReference type="STRING" id="114155.A0A4Q9PX24"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7843" checksum="198C1516ABF04BE1" modified="2019-07-31" version="1">MDDEPRIPWRSETNNEGKEVQVKMIKGGNEVQVKMIQGYREKIESELAKFCEDILDVLANVIHPAVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXB5</accession>
    <name>A0A4Q9PXB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prolyl aminopeptidase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_925762</name>
        <name evidence="4" type="ORF">BD311DRAFT_749573</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXB5"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="36"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="34428" checksum="3789754F98EBB954" modified="2019-07-31" version="1">MATPTLTGTVEFDAGAGKPCQTSYKVYGDLKSGTTPVVALHGGPGSTHHYILSIADLFVKYSIPVVFYDQLGNGDSTHLPEKSGDAGSFWTEQLFLDELDNLLRHLGIQDNYSLLGQSWGGMLAARHATRQPKGLQRLIIADSPADMRLFVKAANEELIPKLDPQVRDALIKHEKAGTTDHKEYQDAMMEFYKQHLCRLQPWPAELHQSFEWMDKDHTVYLTMNGPSEFYITGSLKDWSIIGEASKIEVPTLLFNGAYDEAADSTVLPFFKAIPKVKWYTFAQSSHTPHWEEREKYMQLAADFLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXV4</accession>
    <name>A0A4Q9PXV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_816971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXV4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="167" mass="19139" checksum="675FF569F1D8F0FF" modified="2019-07-31" version="1">MSTVPRQTLTIPDKMIPYLSDQLNLDNVIRCPMIVCKDSHHLHFHTPRICVPEMHPFGPIPPSDTPCWLILLCKLEPAEYQESRVIVLVQHIQSPAILSLAVPYKYFVGDTSSWWAQVVWNVVSRVKILRKPDNEDYLPGEPHCVSLDPITNDWEINDEVQATYSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY44</accession>
    <name>A0A4Q9PY44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_925166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY44"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="7"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="320" mass="34514" checksum="1C86B6FB04D3EC6F" modified="2019-07-31" version="1">MLLNGYEAWVTCEGEKLPEYGIAPEGGDGKTVGCFMPSERGKTFAIQFRNGGNDCISLAFKVDGHKLGHGALCNALQTGSKNGVRTGLNVEQPFHFADLKTTDDDDLLSGLAKQADVGSIEVTVKRVFAEGRPVAAVVDSFKSVEAVHERSKKAGAHSVGLGGKLVVQPFTQMWMYDAIDPCEGFVATFVFRYRPRDLLEAQGIAPRDKPIKPEAGPSRVKQEKKRAGSPDRRNAKRARVQPRSGAGAKLDLGVVEISDGEEDEEIVLARNRLKRAQSQYNKAIAQKNCGRVKREPGASPSAGLKHGDDGGVIDLTLDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY65</accession>
    <name>A0A4Q9PY65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_924790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY65"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY65"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7448" checksum="7F7306C029E28004" modified="2019-07-31" version="1">MYTALRPARVNDKFQDSLYLFLELVRAGVVHGHLWSGRAFSGGPSFGTGAYMELAFPRMMATIVGGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYS3</accession>
    <name>A0A4Q9PYS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane bound O-acyl transferase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_375303</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the wax synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYS3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYS3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF57">
        <property type="entry name" value="OS04G0481900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="9">
        <location>
            <begin position="233"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="402" mass="45631" checksum="F8384CF5933958CF" modified="2019-07-31" version="1">MTFFQGAEQDARVPFSGAAHLLLPELILTLLVAFDIPRAAKFAGSVALLSYIIHTFATTTSGDSVDEYTIGSAVLGNMFFTVIYLVWFNDPMRHFGYLRDEDTSPLSSRPIWSRLYAALSLISNNRMIGWNVQVANVPPVKGTRAQFLVRRARQFILAYVMADVFDCIVRFNRPLYESTLPGGTRFPLGVIGYLQKSWCMVNWLLMTYSTLKVYYVFASIVAVASYASYPEDWPDVFGSWKDAYTVRRLWGRAWHQFLRRHFKQFGSIAVDTLRIPRGTFLSSQVQVHVAFAVSGLLHSFGDLANARATRAGSFIYFFLNGLAITFEDVVIRLAKSFGFTGLTTSTRWLGYAWVVLWVSLSIPVYVDWMNETGVWGKDTVPYSPVREMLLPWIKSTYLFEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q020</accession>
    <name>A0A4Q9Q020_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923014</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q020"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7661" checksum="59E4F630847BA5B1" modified="2019-07-31" version="1" fragment="single">MVNESEARCVPFFVCARMERRRIWLWQGTLFRSPRRRKGTKWASICSSGATAQQRMSAFAQREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0Y3</accession>
    <name>A0A4Q9Q0Y3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_318881</name>
        <name evidence="1" type="ORF">BD311DRAFT_215501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0Y3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU30460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15516" checksum="A98A815E0C1B8AAB" modified="2019-07-31" version="1">MCTRISMRLFRLFPLWLHSRRLPISVVVVVFQRCLAGTSLSITVSLSEPEAGMDAVFCLIAGGRVRRLQRLGEPDAWELARSRGRQFSVIGLSCSPRRPTFGSCPFLCPTTGPSSPVRQPATSASFAAQLSSHRFPSVPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1J0</accession>
    <name>A0A4Q9Q1J0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SHSP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_233924</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1J0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1J0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="135"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="257" mass="26483" checksum="E8BD57D7F97C5427" modified="2019-07-31" version="1" fragment="single">HPYRRPQSRAASGGAGSGAGASAGAASSSGQQHAAVRSRRVSELQSAQTSVGGVSASHTGGALPTVGTPLGVSCPAASSWREGLLGLSTSGQGQSATGTSLGMEAGSAGSGSATPRAQADPLPQSLVLPFPLEPVKRYGIRADVHFSTEENLITAMFELPGVKRDDLRITMSVCPFTRVRQVSVSGISRGVLPLQGHQVRERKFGQYFRALVVPPETKPEDVSVNLEDGVLTLKIPGGTPAEAEQPQSIPILVPMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1Y4</accession>
    <name>A0A4Q9Q1Y4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_1037200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q1Y4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU61217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1404" mass="156361" checksum="9C564D6B853E33DA" modified="2019-07-31" version="1">MKESVSHKAPKVIKKLQFSLLNNQDTVKLAEFEVTHRDLYTPIDRLPVKNGVLDRRLGTTEKSAYCETCGLNSVDCVGHYAYIKLVVPVFHIGYFKHTISILQCICKTCARVLLEEPDRRAYLKRFRRPNLENLQRLNLCKAVLALARKTVYCPYCSATNGVVKKAGALKIIHDKFRAKKTAEEMEKWKRTFGPAVEAQKELGMYINKAVHEDLNPLKVLDLFKRISNEDCELLGLRPEFGRPEQFIWQYISVPPVAIRPSVAQDGASNEDDLTVKLTEIVFSNALIKQGLLKGAPTAQFMEQWEFLQLSVAMYINSELPGVPSQMGQKPIRGFCQRLKGKQGRFRGNLSGKRVDFSGRTVISPDPNLRIDEVAVPERVAKILTYPERVTAHNIDRLKKAVRNGCDVHPGANYVTAGSNGFKKYLKFGNRTAIADGLRVGDIVERHVIDGDIALFNRQPSLHKLSIMCHRIKVRPWRSFRLNECVCGPYNADFDGDEMNLHVPQTEEARTEALELMSVKHNLVTPRNGEPVIAAIQDFITASFLLSRRDTFFDRRQFTQICSYFGDADLQIDIPPPTIWRPVRLWTGKQIFNVLMRPNRKSRVFVNVESKCNKEEKADTKCYPWIGKPAPDLSPNDGWLVIVNSEIMCGVMDKATVGSGKKKSVFGVIMRDYGPHEAAAAMNRVAKLCARYLANFGFSLGINDVIPGPVLSDKKDSMVEAAYAACEKLIIRAKKGLLENKPGCDQEQTLEAEISKVLSDVRGNVGEICMKELSRHNAPLIMATCGSKGSVINVSQMVACVGQQIIAGHRVPDGFQDRSLPHFPKKSRDPPSKGFVRNSFYTGLTPTEFLFHAISGREGLVDTAVKTAETGYMQRRLMKALEDLVTHYDSSVRNAVGGVVQFRYGDDGLDPACLEGDAQPVEYERAWIHACSVAPRSTRGLLPFEIMEYVDRALATRRFTSECTAAYIATIRKFISENIAQKLGEVRKAHGMFEALEREEEWDADTDLSMGASYADKIAVDNKVKVTEEQLKLFLDICWTKYVKAKIEPGSTVGAVGAQSIGEPGTQMTLKTFHFAGVASMNVTLGVPRIKEIINAAKAISTPIISCKLVTADSEASARIVKGRLERTHIGDIASILEEAWAPEYTYIGIIVDAKTIQDLQLELTLDDIKWAIVAARKLKIKQESITIIPRKNRLRIYIDGPDKYYRLRELKRALPDVVVKGVPTIRRAIINIKEGDDHRGKKGDKELLVEGYGLQKVMTTQGIVGEQTTSNHVIEVAQVLGIEAARKTIINEINYTMKSHGMSIDPRHVMLLGDVMSYKGEVLGITRFGVAKMKDSVLMLASFEKTTDHLFDASAYGKTDAIAGVSESIIMGNPAAMTGTSMPALVTPAPSISKPRKLLFEGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q476</accession>
    <name>A0A4Q9Q476_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_919397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q476"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="54102" checksum="07BADC076C2D6ACA" modified="2019-07-31" version="1">MRSHTLNDDILVNILSFASLKTIPSMMQTCRVFYHEGPKVLLASGAAFGGLEQIPAFLRFILAEDGTRCRYLGQFHLLIEEEDDNEEGPVHQTVEMDTGIARSLVALFCHHDFPLLHTLALDPAEMLLTAIPGLSSALSTLPSVKVVNFRSAGPMTCKIIKGMRKLTDVRLAYSPFRWKALASQLHPLFVLEDSRNTLERLDVSFFDEPLPRSRYPQQFSQMRSLKLGWCSQLAIAPFAYAFPHLRRLTYEVMVDHDDLDTDEVIALHQQHRQEFSAYSTWRELEAASGRFFDLYVSGLACQINDVQVFMDPQQTFAMLHDFLNDVRPSKLYLRIPRHGIGVEASALPDLFRSQAGSRLRNLSLHIEFAQEEKDMDLGAAMGALRGALGTLHGLRSLELTFQCSAIPEIRLDVYTPSTLATCLAEEYLQQLDLVDFARSFLLAVPSLERVGVDLTGLRGRSREEVQVLEDGTVTTTINRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q531</accession>
    <name>A0A4Q9Q531_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">BD310DRAFT_974737</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q531"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="136"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="263"/>
            <end position="264"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="291"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU62190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="448" mass="50129" checksum="EBF1D08D63360DEB" modified="2019-07-31" version="1">MSKGISSQLILPKGRGFGLKDGVLDKDQFRKVIPVLAAKVPPEKAGVLLKAPALKRALIDVPKVKSVARGPDQQRLVLFRYTDQADLSPEALEFLQSESAELVSHELTFDYDYWSSDEVIHAILPEELEAEAPSGFAVVGHIAHLNLRPQYLPYKHVIGQVILDKNPSVRTVVNKLDNISTQFRVFSMELLAGDPDFVVTQSENDCRFTFDFREVYWNSRLHTEHERLIAKFSKQDLIADVFAGVGPFAIPAAKKGCAVLANDLNPSSFKYLTLNIAENKVGALVRAFCEDGREFIRQAFNRAWDEPLAPVLPPKIRRTEQKEIRAGERPAPPPGPPRNRIGHFVMNLPDTAILFLDAFRGVLSRANAGERDLSGLYGEASMPMIHTHCFTRELEPAKAEEDIRLRVEEQIGHALGEDATFHWVRSVAPQKEMYCVSFRLPRAVAFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5P5</accession>
    <name>A0A4Q9Q5P5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_918365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5P5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5P5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="46082" checksum="B5113EA9FBAAEA04" modified="2019-07-31" version="1">MLQLLACAGFNPCISPHAIPYEPKQRSLAHDKNFLRATMRCTLPTCGLSTRVQILAVLSFVVIAFIGCFGCCILPDVQSPPSEGADITVSKIQYEGGIMLNGDVYNMDISSRSIQILWQYWSCRNVVDPRDVSNTVGLNWECGMPNVPVEIFFDGAPKPKGSYDPSIMLEGPDTSSSETSVHQELGFNTKHTIHGDFVLGQDKQFYYPFDVFYFETTATALNPDTNVSIPIIQMSVDGATNTFVPHMRTSLMTRSPARDPITGDYIVSHTIQYVLSRTLLTRVFVMVLFTVNWILTFAVLYIAASASTGMPVSEGLLILPLGVILTIPSLRALWVDGPAFGILLDVLGTFTQMVLIALASVYLLVRVALRRPKRQSSAPRIVDSEQASLMRDVMQNDMPARQRSDQTGTQQLTAGASPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q696</accession>
    <name>A0A4Q9Q696_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide binding protein beta subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_974687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q696"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q696"/>
    <dbReference type="OMA" id="PLDSQWV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000020">
        <property type="entry name" value="Guanine nucleotide-binding protein beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016346">
        <property type="entry name" value="G-protein_beta_1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001632">
        <property type="entry name" value="WD40_G-protein_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19850">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN BETA G PROTEIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25391">
        <property type="entry name" value="WD40_Gbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002394">
        <property type="entry name" value="GN-bd_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00319">
        <property type="entry name" value="GPROTEINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="150"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="191"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="38380" checksum="5ABE7FB0EDE27453" modified="2019-07-31" version="1">MSQSPQGDIQERIAAARREAESLKEKIRAKRESSADTSLKAMAANEVDQLPRVVMRPRRALRGHLAKIYAMHWATDRRHLVSASQDGKLIVWDAYTTNKVHAIPLRSSWVMTCAYSPSGSYVACGGLDNICSIYNLHSKEGNNVKGARELSAHSGYLSCCRFLNDRQIVTSSGDMTCMLWDIEAGVRVVEFSDHTGDVMSLSLGPSQNVFVSGACDATAKLWDIRSGKATQTFTGHESDINAVSFFPNGDAFATGSDDASCRLFDIRADRELNAFTHDNILCGITSVAFSISGRILFGGYDDWTCNVWDTLKGERVGVLTGHENRVSCLGVSSDGMALCTGSWDSTLRVWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6I7</accession>
    <name>A0A4Q9Q6I7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_871622</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6I7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6I7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01408">
        <property type="entry name" value="SIRT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF6">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="11">
        <location>
            <begin position="14"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="296"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU62224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="424" mass="45704" checksum="624EAB0E95C97F73" modified="2019-07-31" version="1">MGNEQSAPYEGPTEVLEGRDVRSIVKYMKSKECRKVFVMLGAGVSTAAGIPDFRTPGTGLYSNLERLNLPYPEAVFAINYFAENPLPFYTLARELYPGRFRPTLTHTFVKLLADHALLDTCFTQNIDTLERRAGVPAHRIVEAHGSFADQHCIECKRAFDGAQMKAAIERAEIVRCGECGGLVKPDIVFFGEALPPLFERTVPKLREADLLFVIGTSLTVHPFAALTGLVPAGCPRVLINMERAGDIGGRPDDVVLLGRCDDIVREIAQELGWADELEREWAKTEILVPLEALDREQGAKEKDEERAGVETTVADVPASQSQAAYAEGAPAVSKGQEEEARVEAEVDVLTEKVAQALALSEDAGVEAARTATITPGSQSTTSGPGSEEASEGAAAHSSESDSRPPVGDTRSPEASIAGKEKEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6Y5</accession>
    <name>A0A4Q9Q6Y5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6Y5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6Y5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13255">
        <property type="entry name" value="PH_TAAP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="505" mass="54454" checksum="6CE414D091DAF9B8" modified="2019-07-31" version="1">MSAARSVPPPSHQEVARKLSVHSKPPLKKPTLQSVPVSGTESDSDSVFTPDVISPSPMSTSLSGALLGAPSSQPPLQSIAERRSHSGGEDSEEDEEDEEGGWRTQDFTGTTQQGSHDETVIKSGYLWKKGERRKTWKKRWFVLRPAHLAFYKTSAEYKLLRLLDLTEVHSCTPVVLKKHQNTFGLVSPTRTFYLQAENPQEVREWVSAINDTRVQLLSTSTRNSVTSPIPIPTTPTTATAAFHYTGISSSPSHSHHLHQLTSSDSDDASPNSKPNSATQPVTLAGESVSPSKPVLSGYLMKCGSRRHNWHKRWFVLSGEKLIYCRSHMDTKPHRQIPLALVIDALEYDLPPNRNHPAVASPGPQSPQHHALSSSPADGERVGTHTFKIVTTKRTLLLCAPSEEEEIKWLSAIRALIARRSGQGVVPGEPSSFPSVSPAGNVHVHAPAAGSSGATSPGSAAPTQKRRDSFVRRLSLSGGGSPSLGGSATAPGVATSPQEAPSERQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q761</accession>
    <name>A0A4Q9Q761_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_50113</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q761"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="263" mass="28864" checksum="1A8F1C0D140167E0" modified="2019-07-31" version="1">MHVIVRHWNVFVLFLFILLRRLLRPRMSVVMTPLQSAAWNVCSRLIPVPIGVPVPVPPLSVLLIPRPLHSRPGPIPLLRAGPYDLPRTGVLQCDPPPAEHDNVSLRARDRVRTSRRRRHVLPQRAIPCVVLVPRLSERSLGLRGHRASGWRRRGRRGARGHDGSLGRAPGKERGPLRARGDVVEGEVARGLVADVSRGGFGLLLRVPLAFATHRGCRRGRRGAGEGACALADGVDGVPGRVGEGRGRGERGRWRERGRGGGCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7D9</accession>
    <name>A0A4Q9Q7D9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_1035667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7D9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7D9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="179"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="750"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU63437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="810" mass="87695" checksum="B72AA44186950B3E" modified="2019-07-31" version="1">MITSSFYGGPCMDGRVSPEPVSTLRSRATTNYLASFHSDDFCCIKTGITSPDQPYVTSDVSGGNGPSYLGAFRPSSSLPGFTFSDPSDNSRAPVSGNGANCSLKFPPGLWSEAGSALVNAQSLAQCNFLDLSESFSSLSAGPSSQLAAPEFSLSSLPPSGSGTSVQSEALSHQYFLSNLKFLGTLGRGGYGKVLLAESSRSGNHSSRVAVKVLTKRWMSIDDVREVKTEVQILEALSRRNGPGSAFLQRIHAAFQTKEHVFIVMERLCTTLSDIAIQRQFSLRPQGSSATLGPRTLPNSVSLPATFPSTLPYSDALGSLRLLSAELILGLLFLHGQGIVHQDVKPANVLVSADGHAVITDFGSARLRPLSAPSRTTYAECFDDAPDFSSNSAWEDAPPRATAYFGPIILSANDQVSFTRRYAAPELLYAPVWMSGRNVLVYDERVDYYSLGVMLHELALGDPYDSCNSQDRWERASDGPSRSTTLSVDAAFLSFIDGLLAYDADQRLHGLSVKTHDFLAPFGEAWDDIAALRYPPFVDVFWPDPDPDTRLDLRSYDDEGSPSSSEKGCVANTWSAELADIPYDVGHPPSPSVQQQPQPISSETTVEGIPQPTTLPSQECLSFLPSIPTLDSSILDKFPIIQLKSFQLPHVQLAVPKRKATPLRRRQVIYDLRKAFQFTYTVEHPTRSTCVAGRPTSPCGSAVAICEKQLGTCTPLRRRESGERRMTMSASWSFEDEITIALLSTMDSRNGPAGLHASKTGRSVASGGTTHAARRGGAPATVGLPQLDIDSTFRARGRAILRRLKALMPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7J9</accession>
    <name>A0A4Q9Q7J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_973935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7J9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7J9"/>
    <dbReference type="OMA" id="FMATIWG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="342" mass="37320" checksum="8A218D1752343E24" modified="2019-07-31" version="1">MSDVDLNQGLVLSALGITGALFGFATSQFVYYIQNYWRHDRLLLRIVVPLVWGLDLFHLVLYAYTIFQVIVFARSNTASGLVLPWTGNAQILVNACLVAAVQVFYLHRIWGLSRQLILVIVLGIVSAANLGLGITLMAQTLIIVSVAGLPTLSKFDVALSSVTAASDIFITITLVVLLLMSRRKGSRNNRLINRLMFYPINTGFLTSLCAILSLIMITTKKGTNFYVFFYYIGTRLYTICMIASLNARESLRNDMADAAGIHSIPAIRTHPQHTTSRLAGLRKYSFFATQPSSRSGSESHSGDAPAVLGAQPAPGGKARGLGEGHSADDLRRVHAFSLLPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7L2</accession>
    <name>A0A4Q9Q7L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-mRNA-splicing factor ISY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_916493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7L2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7L2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000001">
        <property type="entry name" value="pre-mRNA-splicing factor ISY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="317" mass="35952" checksum="242B1295DEE7FE25" modified="2019-07-31" version="1">MLYRFREAQAAELGLGTRSDRRPRMASACKSLRECERWRGEILREISRKVSKIQDAGLTDYEIRDLNDEINRLLREKRHWENQIVALGGANYRRNVAMLDDDGKEVPGTKGYKYFGRAKELPGVKELFMSKKTEEDEENRVHNYYKKFTNQGPAYFGDLDEAEGKLLEFEMNAEEEEWKDAYNHLRTVLGLSTDEPIPPIPRPAKQAATISISDASSGPPEPKRKAPDEDGDVEMPPDGSLEVSKRAKTDAPPPTGASNPSSDEAMLAHAKRTAAYIPILSPEILLPPKLPTREEMETYLLELRKKALVEEYFGDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q800</accession>
    <name>A0A4Q9Q800_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histone-lysine N-methyltransferase, H3 lysine-4 specific</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SET domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_945119</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q800"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q800"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024657">
        <property type="entry name" value="COMPASS_Set1_N-SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11764">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01291">
        <property type="entry name" value="N-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="162"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="956"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="17">
        <location>
            <begin position="1079"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="265"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="679"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="893"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="352"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU63579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121637" checksum="347738B8F26BA8BF" modified="2019-07-31" version="1">MRLPVHIPTGPRAQRPPSPAIPQPPSEPPPPRPPSPQLYSLPPPPPWPPEPSEFPPGKNWKVLFDYAIDKDREGQYRALAEKLREKGMDQGDEPRVKGKGKGKEIILRYNGEVIDGEHDAVIRDPRKETKVKRLPSMRPVRAELVQCKYEYDVNSSGPPPPTSVLVLGISPLMPNQHLRRHFGMHGTIMSFEPQIDKSSGGALGIVFIRYMSHEDAKKCVENEHGKKLNIAVPGLGEGEELRVVFDGEGKVLKAVMNELDRRRREKLRREKEEKEKAAAHLKPTPTSSASQTPVHANNPWRTTLRDGGPHRQQGQHAAPRSLLPNVHLPMRPQGLTPMSMTGSPAQHDKASPLPNGTPTGPRNGPARVRRAAPSAPFRARNNVPHPLRAVPPANIRPPIHLFPNGIEAGPVLPPHMQFGLNGVETPPPMPFPPSRSPSPVSRRPQYGRAKKSVDYDVIKAELAKNGFDHIAIDGHVGSVDEEDVEKFMVGFKVDKILRDRHSWYVTFKDRDTAHRALMVLTGTGRTLAHHAVNVTVRAAPTHVPTAHKTQWTDGELLEQAEKELRQELRATLEKDIVERILASQVRRLVAEERTKKGVRTEPVVDGHVAEALEHESKYLDKDALRGLSFRNKKKRPREDMVAPVETAVMTEDDMVVERPKKKPKKAKKVFVEEKLIESEDEETTPALLPPEPTKQRKRAMSEASELEVPVKKKSKSQQVQVFEDNAIPVRTKKSKKTAVAEVLPDTRNVSAFGDEIVHEVVPETLLSGPPTIDEVHVTTPLGFTPSPLASPAAGGPVPIQPPSAAIIDPIAEGICEDEEDMYFAKLALERMLFGKSAASLDEPEHDVELDAPAPFRKHVTGSARTEGYYKISHTEKSAYVAQYALRGMTTTVATETEQTPAPKPAVTSSRSNRANARRRAQGLEEINQVQRAMALSKGEAAAPDSVKYNQLQTRKKHLRFARSPIHDWGLYAMEKINRGDLVIEYVGEVIRAQVADKREKAYERQGIGSSYLFRIDEDLVVDATKKGNLGRLINHSCDPNCTAKIITISGEKKIVIYAKQDIELGSEITYDYHFPIEQDKIPCLCGSAKCRGTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q886</accession>
    <name>A0A4Q9Q886_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RFX-type winged-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_841025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q886"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q886"/>
    <dbReference type="OMA" id="PQRCYEW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052406">
        <property type="entry name" value="Chromatin_Remodeling_Comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003150">
        <property type="entry name" value="DNA-bd_RFX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22970:SF14">
        <property type="entry name" value="AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51526">
        <property type="entry name" value="RFX_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RFX-type winged-helix" evidence="6">
        <location>
            <begin position="343"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="582"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="642" mass="72537" checksum="7A3439AE74DFA91A" modified="2019-07-31" version="1">MSTTASSAQAATYRPGRQTPVPPPQHRPVVTDDYERWYTEATPNNRMLLSLRSGIDSEVAWALDRLCRLCLNEQFMLIAIPGLTDALFEWPEWYVKEGHKQYTEADNFFATPKAKERKRRHAIESLFILRNAGMHEANARELSSYPKIPDLVLRALHDLELNSDANSEFILYILEILQSIASTVTLPIPSAPYCNSPVGPLQQIAGFSSNRSLIISSLITLTTMYSNPVNTYQLSAEAPALETSMNVLPLILDKELIDAALNYLYAHLSYPPMTKAFLRHPRMPGTLRLLVSLILADQLEETVSFEIGLPVYTAPSQSVTVHDHELTKEELDTLLPVPEPQRCYEWMKTMFVAKADGELTQVDFWNLYKDAFAPYSDRYPPLVASDVIKNVNAVFPQAQAMVLPGPPQRFVVRGVDRRKDFSTSTQFKCLWDRSQCPSEPFVSTNELYEHILEQHIQPFEGAHLPCLWSSCPQTEITKAQMRGHVLTHLPDEQPQPKDPNQPDTITLPSVNYPHPIPNPTSRPPPPARSTRVTYMRPHVDPPPSSLTALLCLRVLFRAAYASSDVAPRVDENHFGFPGIVDDLSDEDEEQYGDTEEEKEGKRRGKKAFMAIRYLLEDVRLRHDTFQAWVTEMIDAGLSGVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8A5</accession>
    <name>A0A4Q9Q8A5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1035895</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NDUFAF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8A5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8A5"/>
    <dbReference type="OMA" id="VMDTWNA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05125">
        <property type="entry name" value="Mth938_2P1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034095">
        <property type="entry name" value="NDUF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16981" checksum="81A3212F8A6697BF" modified="2019-07-31" version="1">MGLDTRRPVLLRRDGGLTNILSGGDAPAVQVKTITQNGIQLADGLVLPSPCIFLNGKVFLWNAPAKTWDGWKPEHFEVFDTVVPKPEILLVGTGERVEMMPPALRQYLNKAGIQVDIMNTRNACSTYNLLAEEGRRVAAALLPLTPQNWPDAPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9M8</accession>
    <name>A0A4Q9Q9M8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_392835</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9M8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8154" checksum="44EFCEF02629F87D" modified="2019-07-31" version="1">MSPLSGSRETPDRLLITLQCACLTLGARSHHEPTSKPTQYPTSDDRVRVASGMHGETLDIHCLHSVQAVCDAADAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9V5</accession>
    <name>A0A4Q9Q9V5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_841220</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9V5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9V5"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU63846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="523" mass="58617" checksum="4A14FB9EF9CB75DD" modified="2019-07-31" version="1">MGLPPTQVWTREQVAARILAGDSVFVLNGNLVRVPASWLSLHPGGNLSILHFVGRDATDEIGAFHSQETLQRMKGYVIGQVDVGEDGWAPFVPPIATGWVRRNGKDGKTEWYNEARAVHATTEAEPSILLVKGDGTPPAGPAPTLADLQPAPNSLSLKNEKLNSDAYQELHRRVKDAGLYQCRYITGYGPEIVRYTLLAVLSAVCYSKGWLIPSALLLGLFWQQLTFTAHDLGHVGVTHNWTLDRLISIFIADFLGGLSIGWWVNNHNVHHLVPNHPTHDPDIQHLPFFAISPVFLRSLWSSYYKREMTFDAPAKFFISLQHKLFYVVLSLARFNLYALSYGYLFKTAFEPKKARGGRWWWWAEVFALGLFFTWYGAVLKGCGSWKNILVYLLVSHIAASPVHVQIVLSHFSRSTVDLGPVESFFARQLRTTVDVICSESIEFIHGGLHLQVTHHLFPRLPRHNLRQASLIVKEYAKERGLEYAEFGFADGNAEVRGVLKEVADQIKIIGMVADSEVKEAMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9Z0</accession>
    <name>A0A4Q9Q9Z0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_783489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9Z0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16816" checksum="13F54AB4865FDECF" modified="2019-07-31" version="1" fragment="single">PSRPEAEPDELHNGWGALFKDDEQDEDYAPSECSSDRLSDASDWDPVEAAPETPIPPIYRHNTRVMRERLAFSVSRTRTSVVDRVKSILAFMDSRSALMGSEELPRILERWYKVPRASSSRHHHVRPQGARKALEKFALECVEEIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAN7</accession>
    <name>A0A4Q9QAN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_282545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAN7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAN7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="8210" checksum="B6E61022B10B400B" modified="2019-07-31" version="1">METLQVVNFDPAKVRAHPRVIEWMAQYDGKIPDELEEHTPMIPDESEEHTPMWPETDVDEELELWHDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAU8</accession>
    <name>A0A4Q9QAU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_913147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAU8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAU8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211:SF14">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020670257" evidence="1">
        <location>
            <begin position="23"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="46"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="386" mass="43062" checksum="748709AEA4AA9DF3" modified="2019-07-31" version="1">MFAPFAFLANVASEALLLVASAAPVAPTQIPLDAARSTAQGYSRFYDVQAHRGGRGNTVENTLPSFAWGLIDGASTLELDNGITKDGYVVVWHDEEITPAKCKDTQPAFPGDPDFPYVGKYIANLTLAQLRTIDCGSKRQYGYPMQLTFPGTRISTMQEVFDFVQCADPAHQVLWNIESKIDARYPNRTLGVDDFVTRQYELFSRSPYKRSITYQSFDWRTLVAMKELDPSIPTSALIEDETAFNPDNSTSPWLAGLRLDSFPGPSISRQVAQAAHSIRADVLSPAASASETPVPDPEMEGYVPFTTREMIEHAQRLGLKVKPWTVNRLNIVEQLLDWNVDGIITDYPNHVRRLAKHRGLPVAPKYPKQRVLSCLEEHLAKQLLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBM1</accession>
    <name>A0A4Q9QBM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_302047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBM1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBM1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="167" mass="17893" checksum="6AC0DD8E308B36EE" modified="2019-07-31" version="1">MLLQTLAERCNAILDEAARAAEWGVAPTAAVSDTPQSAGGASGSATMTREHLLQTETESDLILQFLAERPPHDAHLCVVRLKQDLGALRWSRLRYWSAVPRGGGKRRANTFPSPSCQLLRYGSASARAQAGRINNLSASSLRVSIDVASHPHHIVAARIATVGECTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBS6</accession>
    <name>A0A4Q9QBS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_764393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBS6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="152" mass="17598" checksum="1460D2680CD0F0C7" modified="2019-07-31" version="1" fragment="single">SKRFNEKKQEDADGVLVLKSEFNTAWNWFNAKELGETILGYWKTWYEKAESGELLSALDPEFPPPMPDMAGLTEVRGEFLTKFATLDGVVDDNGDSVDGVVYVPDVRKISLIDRRMIVSRKRTRNMFDLTSSWKRMVFQKLDERVLDERDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC92</accession>
    <name>A0A4Q9QC92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_944185</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="41080" checksum="6ADEFB1E60BC0365" modified="2019-07-31" version="1">MRYNQYMAPRLSDLASLDSFCRLVDCNPDLANAVRDLHIRGKTDYSSMRPTPWILQVPLRLLNLLPNLRSITFDQIERVQFSADFWTELEKFTPKVTSLTIKASRFYFDTDLRDLIFAFPNLTSLTLSNVHWGRADETVCPPPRWGRILPLRTLRLNHVPGRSEYVTLFDWLSRSKTVRELEVLQYSHEAFDLLVNYLHQLADKGRSLLESFSFSPSAVLYGRDYVVTYPELGAALRRHVLLRDLHLHIPNMMNGPMAWVPRLLRDLDPAPLTHIALDFTLDVDNADHLTPDWSETNSRLQSQWRKTLQKVTLTHYPVGHFLSDSTAQYILTTRLEHLNERKMLDVFIGERYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCZ1</accession>
    <name>A0A4Q9QCZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_1033881</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCZ1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCZ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU65569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="279" mass="29777" checksum="8D37DFBB231983DE" modified="2019-07-31" version="1">MDGRQPEPEALSPTLALAPVLTPQLQLVAALLLAAFLVAISVVLVRRKSTKRGDAVILVGCSDAGKTTILTALAYRQTLPTHASMQTNAALVALASSHQTIRVIDVPGHPRIRDQFQEHLPSAKAIAFIVDASTISRNGPVVAEHLHMIMNALTSLPPSRETPSLTILAHKCDLLKSTATTSAEQLAINRVRTILERELEKRRASQANGVGVESMGAEESESQMGGLECTGSGEFKFSEWEGGEIGFIGTSVSVAHAADEKHHEVDGLSPLCEWLDDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCZ9</accession>
    <name>A0A4Q9QCZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCZ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCZ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="233" mass="25056" checksum="5A471CBAD96CE30B" modified="2019-07-31" version="1">MYHSPQIQAYHAYFTVASQVVVGLLLVIRTYALYNGSKALLATFCAFGIVMFAATLVAMTVMVPPEPPAKILPQALGCDLSVRAAVGWIAMVCFDTMIFVLTVAKAFRMAPFWHHRLLSILFRDGHIMGLVNSGNLLTLVIGDTNRGFLTSLTNAICTTITSRMLLNLRDPELQGGTLRVGRWSISRTSQVAVAGSTASSEAKTAQAAASDCGPVCNHTTILVEPQPTGRVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDW1</accession>
    <name>A0A4Q9QDW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal recognition particle binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_912463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDW1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDW1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="156"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="170"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="667" mass="72459" checksum="0065CD196E675F03" modified="2019-07-31" version="1">MLDHCSISHKGGVVLWSRSFTPAASHTAASSSSPVNSLVREALIEGRSSDGKYEKDGYAVKWTFVNDLELIFVVAYQRILQLTYVDELLLALKTLFIKLFQPFLATFVASLHVTSTTKLSSSGDPPFLWNFQKAFEGWDAVFDKLLRGLEDKAAQERRTRVVHAPRPALDVTPPSDDVDTVPAVSNADVQDEEQIARNVQALKNRLRGRGGQAGRRGRGRTDVGSGRESVPGSDSETPTSKRKARAKTQRKWGNEAPTESDMVSLDYSYDSASEGRQGTLDVSSLVDSASLGTRTQDGLYEVKDWEFLSQGEKNADDVIAEVLKKGGQEAKPASSSLGALGSIFARLTGSKVLTEEDLKPVLEAMKQHLMKKNVAKEISEKVCEDVGQSLVGKKVGGFQTTTSAVRQALANSITRILTPKTSTDLLLSIRTKLSTPVAASQQRQTYSITFVGVNGVGKSTNLSKVCFWLIQNGFRVLIAACDTFRSGAVEQLRVHVRNLGMLGVDGATNSKGRVELYERGYGKDAAGIAKEAISYARDNDFDVVLIDTAGRMQDNEPLMRALAKLVATNNPDKIIFVGEALVGNEAVDQLTKFDRALRDFSAASGGQERGIDGMLVTKWDTVDDKVGAALSMTYVTGQPIIFVGCGQTYTDLRQLRVANVVQAILSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDZ7</accession>
    <name>A0A4Q9QDZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_1034169</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDZ7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDZ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="13">
        <location>
            <begin position="5"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU65925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="378" mass="42400" checksum="6A2534DD45F9D6D1" modified="2019-07-31" version="1">MSATPVPCQSSNCIKDRPPSRLECPTCNKLGIKGSFFCCQECFKANWKTHKIIHDIATPRQPLLDDPNINKDGTFNPFGTFKFTGPLRPVYPLSPKREVPAHIPRPDYAEDGIPTSENRKLGLPPRILAPEEIEKMRNVCKLAREVLDIAAAAIRPGITTDQIDAIVHEETIKRDAYPSPLNYRHYPKSVCTSINEVICHGIPDQRKLQEGDIINIDVTLYKDGYHGDLNETYPVGRVDEDSQRLMRTAHKCLHEAIKLCKPGALFRDLGKTIEPIARQKGCSVVRTYCGHGINDLFHTAPNVPHYAKNKAVGTMKAGMTFTIEPMINLGHWDLEHWPDDWTSTTIDGKRSAQFEETLLITDTGVEILTGGRSREDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEW0</accession>
    <name>A0A4Q9QEW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Polyadenylate-binding protein</fullName>
            <shortName evidence="13">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_837014</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEW0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEW0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12380">
        <property type="entry name" value="RRM3_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12381">
        <property type="entry name" value="RRM4_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1900.10:FF:000004">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000441">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000520">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 12 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="134"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="231"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="334"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="16">
        <location>
            <begin position="585"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="491"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU65796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="666" mass="72185" checksum="A180FC4F823294C8" modified="2019-07-31" version="1">MSASPAIAPAPDAAVPQHVEAAVPPPPAPAPVAYNPPPPAQITPSASLYVGELDPTVTEAMLFEIFNMIGPVASIRVCRDAVTRRSLGYAYVNYLNAADGERALEQLNYSLIKGRACRIMWSQRDPALRKTGQGNIFIKNLDEQIDNKALHDTFAAFGNVLSCKVATDEHGRSKGYGFVHYETAEAAETAIKAVNGMLLNDKKVYVGHHISRKASSRERQSKLEEMKAQFTNIYVKNLDPEVTQDDFVKLFEQFGNVTSAVIQTDEQGQSRGFGFVNFETHEEAQKAVETLHDSEYHGRKLFVSRAQKKAEREEELRKSYEQAKVEKMSKYQGVNLYIKNLEDDIDDERLRQEFEPFGSITSAKVMRDEKGTSKGFGFVCFSSPDEATKAVAEMNNKMIGSKPLYVSLAQRREVRRQQLESQIAQRNQIRMQQAAAAGIPGGYLNGPMYYPPGPGAYPPPGGRGMMGYGQPGMLPPRPRYAPNNQVPAGIPIPAPYGQAPPQAYGGIPGYPRAPRGPPPAGRGGPPADPNSPPVNGAPRGNAPQGAAANRPPAGGQPPAARAPTANRLQARQAPPAAVAAPTGEVPTITAAALANASPMEQKQMLGEVIYMKIAPSQPELAGKITGMLLEMDNTELLHLLESPDAMNSKVNEALAVLHEFTKEESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K0L1</accession>
    <name>A0A4V2K0L1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_822461</name>
        <name evidence="3" type="ORF">BD311DRAFT_806325</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143414">
        <property type="protein sequence ID" value="TBU29333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K0L1"/>
    <dbReference type="OrthoDB" id="3337916at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040598471" description="Polysaccharide lyase 14 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="2">
        <location>
            <begin position="88"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU29333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="311" mass="33305" checksum="3D0E89105EEEB37D" modified="2019-07-31" version="1">MLLTFAFTLALVLSSVSAVPHSCPVQSSNNASASASSDKTLFPILSNDSWSVSSQIRNALPFNDATLRPTKEAHDYSHPYVSAPDGVYSIKAFYPKGSYNPSGTPRGGLSFYAPGPQSVDLTTAREATLTYSVLFEEGFDFVKGGKLPGLYGGNSDEEAYSCSGGRRDDGCFSVRFMWRTAGAGELYTYLPPDAANNKAHLGGVKPMSTCNPTYGCSVGRGSFKFAAGTRTIIGERVRLNDVGQQNGELELFVNGRSIFTVTGLTLRTADSGRIRGIQMQTFFGGSDASWATPKDVNSYFGDFSVAITEQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K3C9</accession>
    <name>A0A4V2K3C9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_961770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K3C9"/>
    <dbReference type="STRING" id="114155.A0A4V2K3C9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="196"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="755"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="871"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="720"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="17"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="508"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
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        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="630"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="887"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="954" mass="100272" checksum="EDC6B6345C8BDF17" modified="2019-07-31" version="1">MADTQRASQIPVMSPRVSHSGSSSLGGLPSPHLGLVPPSRYPSVSGSPSLVSPPTSPSPPSSGGVSTPFRTFRNFLSFGSSNKHAPSPAVPSAIPKNHFGSLGPVRRSVNVERRASSPQLARRSQDDYVLSIDLPRPGDEKPPNTRSSKSSNASPVSQSPLSSSQSSAADSAASPAGTPALLASELSTILEAETSGISKHLPSLDTSQAESERASDISPNAFQPQALYPPPRNTRHGSSSPSNDTSALDLSTSKLTSEVLAALSETGGQQDWLNGVVVDDVPSDTAISRERTPESPDTSFNLNSLDPDLAALLSPNRVYGSSTEPAVLLAIDAIPPPASSSPPSPTKPTFSPRAKTAELQASTSTRRIPTSLSVASRLPSHSSTIPRITRSVSDRPIFSPTGKSGPPSPITRTPSGRAMSSSPERPSSMSSASALSRLSRASPGDITATANSSIRRPGSSGNREERRTPASRLMTPARPSSSSASTSTSRPPMSRLHSTPNSVWEADSASPSSRAPSSIGTAPSRLQNHRPSLDIERPRLTGSVRTRKRSTSVIENRVTSTSPSHPPVSLPAPRNMADWLGPRTAKAFAAAGLLDFDKDSSPASASRPPSRFGPSRSSIDRDSRSRYTPSRMAYSEAGSSSSYGARSGSISRAAGYSESPSTTGPMSETMSPRTVFSSASTAPTSVSASSLNSEVQLLQEKHALETSALLSALADSQRTTRMLRDENGQLRERIQMLEDKLADAQERIQAILYSQPPAVPPNPMYPSKRYGSPASSSDRRLPAHSRTSSFVRRSSPGPAFVSPETPYDAASAFVPSYRKRASVESSVFATLPSNMSMIMQEEGAPPDTFTAFSQNSSSPPGSPTMVLARVNAGHSPSGYPSIPKGPSSRSGYSHAANKSVSSAGNISPTTANFSIMTSSPGSLNLRPEHERHLGDMPPLDLDAEGFEFDDSSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K3U9</accession>
    <name>A0A4V2K3U9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Fcf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_924663</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K3U9"/>
    <dbReference type="STRING" id="114155.A0A4V2K3U9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="194" mass="22560" checksum="4334A9C2FC27A24D" modified="2019-07-31" version="1">MVKAKKTRKFAAVKRMLNPKDIRLKENQLKKKQKEEAEKERLVKRAPQVASSLFLQHNTALVPPYRVLIDTNFINFSLQNKLELISGMMDCLYAKCIPCVTDCVMAELEKLGHRYRVALRVARDPRFERLTCSHSGTYADDCLVQRVTSHKCYIVATCDRELRRRIRKIPGVPLMYIVRRRYAIERLPDQGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6S5</accession>
    <name>A0A4V2K6S5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_159975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145216">
        <property type="protein sequence ID" value="TBU53353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6S5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="15206" checksum="EE051BC939BDAD56" modified="2019-07-31" version="1">MAEDVAEMVTRDEAFPSPGSSVGRWVTFLALVTPTKAQSFSAPEATRGSPRSAKSGRTPVLDARRRFRWLLQWGLRPRFRGLLRVRAHVGATRLHLQYHHLCRSVCVPRRISYPFNHDAVFQAVIEVPRPRAFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K795</accession>
    <name>A0A4V2K795_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_826267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145172">
        <property type="protein sequence ID" value="TBU55238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K795"/>
    <dbReference type="STRING" id="114155.A0A4V2K795"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="197" mass="21122" checksum="3BE95FDF5C2F8E17" modified="2019-07-31" version="1">MSVTASNITNLLMSLNAPPVRSSTSPHTSAPLPAERDCERDFGSFGDYDDTGLWNRGRHPKHILCQPEREQHMGSLLWLCSSSSSPFWLSQARGGLKPCYGGPSSGTGDKISERGISQSSTRSGRPLVSRASSMASSNLRSSMLSAGTSTWAFTRYSNNSPLGFDGGDERVIAELAQPRQQGIPGSCPSPDACERQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7S7</accession>
    <name>A0A4V2K7S7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_561183</name>
        <name evidence="1" type="ORF">BD311DRAFT_759001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143424">
        <property type="protein sequence ID" value="TBU28200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU57288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7S7"/>
    <dbReference type="OrthoDB" id="2729416at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="219" mass="25990" checksum="65632BD98B50772F" modified="2019-07-31" version="1">MPNTVTDVKNSAYWENGQYLYEWDRERGDRYTEAAEKAQEVRWKRLMANRPPRDVLPRKLLPGPDRKPPLYHYGFPFTRTYALDYVCHRHLPVDIPEEDREEFGGRSVLDMAELTDEWLAANEDMQVFAMSISSFLMVKDLSRKCHFGLNHGRPFSLEWDGIVSLWTNYNFDERYAYCPDDEKVIKTIKDALAEVEGRRSLKAQWWFDWDNDVGLFHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K869</accession>
    <name>A0A4V2K869_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_818612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K869"/>
    <dbReference type="STRING" id="114155.A0A4V2K869"/>
    <dbReference type="OMA" id="REMIAFQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
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    </dbReference>
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    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8825" checksum="461D775B732407AC" modified="2019-07-31" version="1">MIDAIPIPKYDVRVGSPLIPQSTRGYDIILSMKFETLQDFKAYLAHPKHLELLKVYGPPLLREMISFQVDGTAPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8P1</accession>
    <name>A0A4V2K8P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_921998</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8P1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6529" checksum="63F35487B369780B" modified="2019-07-31" version="1">MARYQPHLWCPLFSKGSVYVEEEGFPRRLTLPLRHFVRGDECYRRSRGFEGELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8R3</accession>
    <name>A0A4V2K8R3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_1037332</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8R3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="201" mass="22791" checksum="2B68EE0E803AE67F" modified="2019-07-31" version="1">MTKRVARTPPLVCTGYELTNALRRYLEVGHGVDFDEEIATAIEEDKELRGDAYDEADEVALAPQRAAGVVKSCQQHFSRVREGAPAEDRKVLEIPYSYGKWAGDHRKVYLFVPTGAYINEDGTSGVLKTPREKDLKAIQAFIDAANSLLPEAVRDEASLKLEDLRFEVHTPRSLLQPAYKRDERKELLPPRHLRPLFNYPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M7A3</accession>
    <name>A0A4Q9M7A3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Saccharopine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_940472</name>
        <name evidence="9" type="ORF">BD311DRAFT_706666</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143581">
        <property type="protein sequence ID" value="TBU21732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145256">
        <property type="protein sequence ID" value="TBU52316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M7A3"/>
    <dbReference type="STRING" id="114155.A0A4Q9M7A3"/>
    <dbReference type="OMA" id="ECLWIHL"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="8">
        <location>
            <begin position="11"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU21732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU52316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="753" mass="82285" checksum="1B70C648CDD1A686" modified="2019-07-31" version="1">MAPLTHPSIKDGWFREISSQWPGQAMTLKVNKILHVEKSLYQDVLVFESATYGNVLILDGVIQCTERDEFSYQEMIAHIPLASHPDPKKVLVIGGGDGGVVREVLKHDSVQEVVLCDIDEAVIRVSKQYLPHMSALLNDPRVTVFVGDGFKFLADNTSTYDVIITDSSDPVGPAASLFQKPYFELLRDALTPGGHISTQGECLWIHLDLIQDLLKTTRSLFPVAEYAYTTIPTYPSGQIGFMVASKEAGRDLSKPLREVPGTRYYNAEVHRAAFVLPEFGRALLKEGKDVRPKFGASAFTGTPSKKVLLLGSGAVARPCAEYVVRNPNNALTIACRTLKSAEALAADLPNTTARSLDAGSEDPAKHAALEQAIADADLVISLVPYTYHVNVIKAAIKGKTNVVTTSYISPGIRALEDEIKQAGIVVMNEIGLDPGVDHLYAVKTIDEVHAKGGKIKEFHSYCGGLPAPECSGNPLGYKFSWSPRGGLLALLNDASYLARGQQVDVPGKDLMSVAKPYFITPAFAFVAYPNRNSVPFREFYAIPEAETVVRGTLRYQGFPEFVRALKALGWLDLERKEWLKEGLTWAEVFQRAIGAQDANESTLVARVREICAFPDEGEAHRIVSGLRWIGLFSQEKATVRDGNLLDTLCAQLETLMAYEPGERDLVILQHKFIVEWADGKTDTITSTLEAYGNPSGHSAMALYVGVPCGIAVQLVLDGKINTPGVLAPYSKEICDPIREILEAQGMGLVEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MAS5</accession>
    <name>A0A4Q9MAS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_926584</name>
        <name evidence="2" type="ORF">BD311DRAFT_769789</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143527">
        <property type="protein sequence ID" value="TBU22761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MAS5"/>
    <dbReference type="STRING" id="114155.A0A4Q9MAS5"/>
    <dbReference type="OrthoDB" id="2750489at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU22761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="48776" checksum="C3944D45157C1A96" modified="2019-07-31" version="1">MSLLPSSSLSSALTVVVPPSIHCTGGFVEGEVQLNFRHLQEEDINQVHIALRGEIQSRARRGRRTYEENHLILNTSLPLWSKGSAYPPPGSDILRLPFRFHLPEGIPPSFHYSKWYPDIGGSVVYVLETTGVREGLLKVNKRIPTPIVVTPRDEVGAAVRAGTSTAWKNVRAEEKIRKGIWGEYATARVVLSIPDVPVLPLFAELPFVIDITTTTAPLARAKADALPPDKPIFPAPPVAHSEIQFRLYRNLVLSPKGYVWTTDDAVACFFGAGIDARDVVADIDLPEKQWVVDQVSPHDGEEKGSWVQRSVFTSKFTLNLPPTFVAPGLTVQYYLSLEVPFPGIGNDIRIQVPVVISSGITESMPRSQTGQPQSQPQRSSLPLRQPDPVAISSSSASDAGSDVRSPAAASGPAPAYKPRSPKRDLSLPPEYWEAANNEDGGHSTKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MBW7</accession>
    <name>A0A4Q9MBW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_850837</name>
        <name evidence="12" type="ORF">BD311DRAFT_767397</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143490">
        <property type="protein sequence ID" value="TBU23967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MBW7"/>
    <dbReference type="OMA" id="FYNIGWN"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="36"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU23967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU58659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="528" mass="59110" checksum="0A2272DF820077F6" modified="2019-07-31" version="1">MAIGVGRNDTALNRYIDEDKVPWYRKKNLRLLYLLMFPTCIGIEMTSGFDSSMMNGLQAVPTWDAFFGHPRSTILGLLSALYSLGSICSLPFVPLVTDKLGRRWAIAFGSVIMIIGAALQCASQDFAMFVIARFLLGFGIPFAIVAASSMIGELAHPKERARMGSLFNASWFIGAIVAAGVTLGTFQMPTNWGWRIPSILQVTPSVLQIVFIWFLPESPRWLISKGRGEEAYAVLAKFHAEGDVNSEFVKLEYAEIEKTLELEKEQQKGSWREFVLAPGMRKRLLICSFLGLATQWSGNGLTSYFLARILDSVGITDDRTQNLINLAMTCWGFINGTALALTMPKLPRRVGYLACTISLTVIFTAWTVASAKYAETGSQGASRAVIAFIFLYSPAYNMAYNALTYTFLVELFPFHARAKGIAVFQWWSRAAGFFNQFVNPIGIANAGWKYYISYCVFLVFEILFVYFLFPETANRSLEELAFLYEGDKVRAEQQKRVEEDMLVLENKPPIPEHASDKESAFHVEVSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MDV9</accession>
    <name>A0A4Q9MDV9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_930213</name>
        <name evidence="2" type="ORF">BD311DRAFT_790767</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143472">
        <property type="protein sequence ID" value="TBU24787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU57040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MDV9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MDV9"/>
    <dbReference type="OMA" id="TEISPWC"/>
    <dbReference type="OrthoDB" id="3333333at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="62"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU24787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22835" checksum="F3D8F95941434023" modified="2019-07-31" version="1">MADTIGKWAPGSCYGPVLTQTDLYLLGTELELNPILANTSESFQLIFNLSTGQTGGYNHEARDRDTPFTAKEEPATMPRVEELIIITELSPWCTIIKNPQGVTLGDICGTLFKEYGEKMVTEKEFESLPARLQEQVRRYASSAGNAGWQQYYSPQVAPTQFRRVDWLRERVFFDKLSRKDSYAKARLGFSAPNIFVLSLSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MGW4</accession>
    <name>A0A4Q9MGW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_821222</name>
        <name evidence="3" type="ORF">BD311DRAFT_668845</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143455">
        <property type="protein sequence ID" value="TBU25818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MGW4"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="193"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU25818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="41718" checksum="0FBC2273A8B1B888" modified="2019-07-31" version="1">MPSTTLPVVPHYVAASLTKENLDWADLPIIDLARATTPEGRAELAPLIRDAMRTHGFLYVINHGWTEAQNERIFDIANLPFEHVPDDEKKRFAGDIKKTGSYRGYKLRNYWHIDNGVRDQLEHYNLHRSIYENQEHPKALQPVLPEIRAFAEHNHFNVLFPVLRLLALGMELPEDTFINIHGFEAKGETYVRFMKYYPRSEEEETKTSNVWLKGHTDFGTITILWSQPVTALQILSPDGVWRFVKHIPNALVINAGDGMEFLSGGYYKATIHRVVQPPVDQRGTTRVGAFYFAMTDDDVVLKPLAESPVLQRVGIVRRFEDENAPTTEQWRRARTSAYGQTELKRKDNVEEEVINGVVVKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N0W4</accession>
    <name>A0A4Q9N0W4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rho GTPase activation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_705211</name>
        <name evidence="4" type="ORF">BD311DRAFT_435732</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N0W4"/>
    <dbReference type="STRING" id="114155.A0A4Q9N0W4"/>
    <dbReference type="OMA" id="IAQQDWF"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="74"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="404" mass="44937" checksum="BBE83F38AFF432B3" modified="2019-07-31" version="1">MTTAHAPHTNPQAQTQEPAALAMTKAGLKSWWNSFTFAQRAKKEAEEKKAAGGAEPQNVVFGKPLKESLKYASVQISTANANGELYVWGYIPVVVAKCGLYLKENATEVEGTFRVSGSNKRMKELQAAFETPPRYGKDLEWTKEQFTTHDVASVFRRYLTQMPEPVIPHDMYHLFRDALAKKPRNEDEVIATYKRLIRSMPRANQYLLLYVLDLLSVFARKSDKNLMTAKNLAVIFRPALIAHPSHEMSPQEHQLSQDVLEFLIKHQDWFMLDIPPPPTTKPSDSAVTVPMKEPVADILASSDEESGGWKLISRDAVPKKIGRRRTTTERSGEKSPAETGQLSPVVEAPPSRSNSVVTVTRSRTLPSSKSGRLPEEERHAKLVKKQKRASVQPGRTASGGANAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N3S4</accession>
    <name>A0A4Q9N3S4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_954229</name>
        <name evidence="5" type="ORF">BD311DRAFT_828054</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N3S4"/>
    <dbReference type="STRING" id="114155.A0A4Q9N3S4"/>
    <dbReference type="OrthoDB" id="2094832at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU34845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="35025" checksum="A4B3D0D4202A68D0" modified="2019-07-31" version="1">MMVSLSAKPTDVPALTSSIERPARDPLLEASYSSITKEELDFVGEQTGIRDEDALREHILQVQAEAFSIHPYPCIRRFAFIKMKLSPRIPAYNGLLKLGREREGAILLDIGCCFGNDVRKAVSDGFPVDNCVATDIHPEFWDFGHKLFGTTQETFPARFFAGDVFDPTHLEPVAAFTSAPATPRPDLPTLTSLNPLRGHVSAIHISAVFHLFSEEEQVQLARSLAGLLSPEPGSIVFGLQSGRAEKGFRVEAGLPSSHGKQMFCHSPESWRELWEGVFPPGTIRVDADVRELERDDLKPVADGAKFWVLTWCITRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NA02</accession>
    <name>A0A4Q9NA02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="10" type="ORF">BD310DRAFT_908538</name>
        <name evidence="9" type="ORF">BD311DRAFT_797798</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143433">
        <property type="protein sequence ID" value="TBU27352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NA02"/>
    <dbReference type="STRING" id="114155.A0A4Q9NA02"/>
    <dbReference type="OMA" id="ICQGDHF"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="208"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU27352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="290" mass="31170" checksum="93AA30BC64B560B7" modified="2019-07-31" version="1">MASTAPKTYWADEVDELEQPKGEDFVDENGIRTTVEYTINDEGKKITRKIKRVLQKAVVDHSVAERKAWSKFGQEKGNKPGPDRATTTIGENVALKLSAGNKAAAQEQSAEQAVKTNLAKAGAGKVICRLCKGDHFTAKCPYKDSLSGLDGADTPPLGLDDTGTPAEPAAAAPTASTGGKYVPPSMRGGGRGPGESMGRPGGSRDDLPTLRVTNISEDTQENDLRDLFGGFGRVARVYVGRDRETGAGKGFAFVSFEEKAVAQKAMEKMHGRGYDNLILNIQWSQPREQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAS3</accession>
    <name>A0A4Q9NAS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA topoisomerase 2</fullName>
            <ecNumber evidence="6">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_834698</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 6">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="6"/>
    <dbReference type="EMBL" id="ML145341">
        <property type="protein sequence ID" value="TBU51309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAS3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NAS3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="9"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DNA topoisomerase type IIA subunit B" evidence="8">
        <location>
            <begin position="194"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU51309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="373" mass="41264" checksum="2E5DB703EB06BA2F" modified="2019-07-31" version="1" fragment="single">REVKYVLEFFKIVDEILVNAAVHKINDPSMDIIKVTIDIENNMISVCNNGRGIPIEIHSEETIYIPELIFGHLSSSEDDGKGKTLTGGRNGDGATLANIYSTEFTVETADKITSQKYVQTWTENMNKVGKAKITKNERGEEYTRVTFKSDLKRCGMKSIDDDASSLLEKRVYDLAGTVKDVKVFLNEEQLKIKNFKEYVELFVKSSAEAAANDTDGAAQLETCVIHESLAGGRWEVACAASDGAFQQVSFVNLISTSKGGTHVNHIADQITEHLVTAVAKNMAAAARPAQIKNHMWIFVNALVENPTFDSQAKETLTLPASKFGSEPRLSEVFMEKVAKSSIVDHVLNWAELKADRRPKKTDGSQRSRLVKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDP8</accession>
    <name>A0A4Q9NDP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp10-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_940279</name>
        <name evidence="5" type="ORF">BD311DRAFT_760354</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143431">
        <property type="protein sequence ID" value="TBU27569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDP8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NDP8"/>
    <dbReference type="OMA" id="EDFLIMR"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU27569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU52463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11456" checksum="DB460E70AD023A97" modified="2019-07-31" version="1">MAAQATFKSIKSVIPLFDRVLVQRFKPETKTASGIFLPSSSTSNPLPEATVIAVGPGAPNKDGNVQPVSVKAGDRVLLPGWGGSPIKVGEEEYYLFRDSEILAKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NE62</accession>
    <name>A0A4Q9NE62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_167002</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145220">
        <property type="protein sequence ID" value="TBU53236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NE62"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF10">
        <property type="entry name" value="SLC (SOLUTE CARRIER) HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU53236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="312" mass="34038" checksum="E00DAD43E201E84E" modified="2019-07-31" version="1">MKDTPEAKLRQISPALDFLAGTVAGMAAVVVGYPFDTVKVRFQSPQIASKYRSTLHAILTIIREERMRGLYRGIAAPLAGAPPLNGLVFSSYRSLLRAQLDDDQATPTLTQVNLAGAGTGIICSLITTPAELVKIHQQTLVRSAYSAVTLSDRDVILHIWRTHGLRGFYRGITATALRDIGYGAYFAAYEATLRYWPRPHASLPEQHSTCNKEVELTPAPHPWLALLTAGGMAGIAGWIVTFPFDVVKTRVQSTPANAPNKLYRSTWSTIIASYRAEGVGVFFRGLAPTLIRAIPVNMVTFATFEAVIHLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEN2</accession>
    <name>A0A4Q9NEN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_838025</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEN2"/>
    <dbReference type="OMA" id="HEGFFMG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="282"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="347"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="434"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="503" mass="54539" checksum="B6CBF028CDB84446" modified="2019-07-31" version="1">MAASPLAAHTDSERAPVKHSDSWNPMDDSARDHMGPGGDLDLNGGAPPADDRAVPGAEGAEYPAPGSVNGNGTDSGDATARSDAAQRGEKIVKDPQGFVTWQPSSANGLAASATLNKVYIGGLPEHTRKEDLESCFGKIGNIVNIELKVGYGFVEFDSREAAEESVAKYHEGYFMGNKIRVEISHGGGRTAKYSGDPGACFKCGQMGHWARECPNHLAAGRRPSHLGSEPPLIDRLTAARDYPPPLRDYPYRGDYPRYPPPGDPRYYDYPPPPRRDGFYGRPPSPPRDYRDYPPPPIRSARDYDDFRMRGAPPPPARLDSRGYYPEGEAVPPPGYPPRGYPPPPPRDYYDRYDRRTGAPPDRYGTYPAPASVRPRTPPGAPPARAARDDYDRPPVREYPPSETRGRAASPARYADYPPPRTGSVEAPRYRRRSQSPPARSASGAPYEPAGYTSTGGATYNGSSGGYGTNGYSNGAPARSSGSTRDYPPPRSREVEPAGGYRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NF94</accession>
    <name>A0A4Q9NF94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efficient mitochondria targeting-associated protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_192359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM97/sigma-2 receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NF94"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051987">
        <property type="entry name" value="Sigma-2_receptor-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016964">
        <property type="entry name" value="Sigma2_recept"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31204:SF1">
        <property type="entry name" value="SIGMA INTRACELLULAR RECEPTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031032">
        <property type="entry name" value="TMP_97_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="21158" checksum="28AC2EC5EE3DAD5C" modified="2019-07-31" version="1">MTRTPLSSRPRDLVYFLFFAIHLPATFLIDIQAIYPKAWVPALISSLPKFYVEMSNDPLIGSAMGYFGESQLKAFTWFWSFLLLEAFFQVPVFLIGLRGLWRGSTSIYVLLLIYAASTATTTIPCLAVILSTPVSPTPLSGISITAEQRLLLLSSYIPFCLVPLVMTFDMAFRVQKLTGSGSGAQKEKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFT6</accession>
    <name>A0A4Q9NFT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_934649</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFT6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="390" mass="43956" checksum="682C0E379927BD9C" modified="2019-07-31" version="1">MPSPTIVASFRITLLSSPRSCLRHIRHTPHWPGRRPTVCQARQLTTGNLESGEDSTQPERLKRRWQRRTVCTLDSTKLTPTDYVDFSMLTQPNVQLVARSSDPNDASNTSLGRPLARITARGFRDRRFPPNTAGFLYYHTPPYSPPLAGELRFRITPSPDPASFSQGSDLLTEYGVHWKIPLLYMTGKKNYTGLHRLLLQGGLVTPQLLDVAASAAETLINTDYGQKIGFSMAALVSSFGRGFNLRVGGYNGLCLMIGTNTILKKEISSFASMFVPVDGIRGSARYFPFEGSMICCFEPSTLPEHAGRRVVVLRVLRLLDNDPIRSVPPPTKHEYPLSTLRPREGQLFMTMRWGKVQPWSVDVDRDTRRPATHMGMEKMLRILYENQELY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFW0</accession>
    <name>A0A4Q9NFW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_942166</name>
        <name evidence="5" type="ORF">BD311DRAFT_793787</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU33998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145319">
        <property type="protein sequence ID" value="TBU51461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFW0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NFW0"/>
    <dbReference type="OrthoDB" id="2432613at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052982">
        <property type="entry name" value="SRP1/TIP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633:SF1">
        <property type="entry name" value="GPI ANCHORED SERINE-THREONINE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G03630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40633">
        <property type="entry name" value="MATRIX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040683839" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="26"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU33998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU51461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="267" mass="26657" checksum="CFB74DE825C2774C" modified="2019-07-31" version="1">MFAYAALAALIANAAFARAEVVPTAPGPGDVFKQGGQCTFTWTPDTTGVWKQMNVELMSGDNWQMSHITTVATNIDGTDATKATFSYNCPEVTPNSAIYFYQFSTPSAPSNLTWTTRFTIAGADGSTTAPTNQTQPDGQSIPWGVGALVDPSTAVAAPNYIASSGAAATTNVGTAASNTAVAGTTAAAATTSVVATTSAAPSTSSKFVTAPAAPSASSSANTNTSAAQQNTTGSAGNGAASLLGSDSYAVRAGIAMGLAAFTFAFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJ61</accession>
    <name>A0A4Q9NJ61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_951713</name>
        <name evidence="4" type="ORF">BD311DRAFT_669436</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143459">
        <property type="protein sequence ID" value="TBU25554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145199">
        <property type="protein sequence ID" value="TBU54023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJ61"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJ61"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU25554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU54023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="216" mass="25037" checksum="7A9D429E66FF9C68" modified="2019-07-31" version="1">MGRRPARCYRYCKNKPYPKSRYNRGVPDPKIRIFDLGRKRASVDEFPYCCHLVSDEYEQLSSEALEAARICANKYVTKTSGKDSFHLRVRVHPFHVLRINKMLSCAGADRLQTGMRGAWGKPYGTVARVNIGQIILSIRTKDSNAAVVQEALRRARYKFPGRQKIIVSRKWGFTNVNREDYLKLKEEKRVLQDGAYVQYIRPRGNLENNLRAQLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NK07</accession>
    <name>A0A4Q9NK07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_390477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NK07"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="220" mass="22727" checksum="FD21AAF3E570AE52" modified="2019-07-31" version="1">MPSSVVVITGNTSSVRILCDAKSPYADTAEAAATRKSISTLLGHFEPGSDAGPPFAFAPTKLDISPEIEGFLKQFTVAAGAAAASVFCGSILAGHTSEADDYGDLAFYLGPGDYGPGHEQDVLRALGFGYSQGLTSSDIASRKATQPVELSSTDGLPTTFNIAADASSGGTVKRLRDILKQLSDRYAFCVSGPGVLVIYFLVGRLGASEWIGLTGIGVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPT2</accession>
    <name>A0A4Q9NPT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_921877</name>
        <name evidence="14" type="ORF">BD311DRAFT_754148</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143404">
        <property type="protein sequence ID" value="TBU30660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPT2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NPT2"/>
    <dbReference type="OMA" id="YWARRTA"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="18"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU30660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU60976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="14702" checksum="21C5B9CF5CD3BDFE" modified="2019-07-31" version="1">MSGKGKAGKSSSGKAGGEAGKSQSRSAKAGLQFPVGRVHRLLKKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKQRIVPRHLQLAIRNDEELNKLLGDVVISQGGVVPHINPELLPSKSNKGKKEGASQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR16</accession>
    <name>A0A4Q9NR16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thioesterase-like superfamily-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_913413</name>
        <name evidence="5" type="ORF">BD311DRAFT_745388</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR16"/>
    <dbReference type="STRING" id="114155.A0A4Q9NR16"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03444">
        <property type="entry name" value="Thioesterase_II_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03445">
        <property type="entry name" value="Thioesterase_II_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="entry name" value="Acyl-CoA thioesterase, double hotdog domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049450">
        <property type="entry name" value="ACOT8-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049449">
        <property type="entry name" value="TesB_ACOT8-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066:SF34">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13622">
        <property type="entry name" value="4HBT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20789">
        <property type="entry name" value="4HBT_3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA thioesterase-like N-terminal HotDog" evidence="3">
        <location>
            <begin position="39"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA thioesterase-like C-terminal" evidence="4">
        <location>
            <begin position="170"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU34991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="34896" checksum="DCDC95FFFC1B4E2F" modified="2019-07-31" version="1">MVAVDSQEHEQISEALEIEQLDVNLFRSKTLYLPFRSRGVFGGQVISQSLVAATSCVDTAYSLHCYFLLSASAAVPIVYHVDRVRDGRSYVTRSVRAVQRGRTVFIMMCSFQIPEPRQPTFQFPMPLGVPPPDACDSIESLYEKAFRQARDEKVKELWRITLEERMRSPIEAKIAGVREPTDGTPIFMYWYKARNTPRRYDPAFQKCILSYISDSQFMSGIRRTLAILHRGYDSDAKVVMQTSLDHNITFYDDDFDCGDWILYVVISERAASGRGSVHGRMYTPSGTLVAICNQEGLMRVDIPSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NT11</accession>
    <name>A0A4Q9NT11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1016015</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NT11"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="531" mass="59707" checksum="9F8E0251617C05B6" modified="2019-07-31" version="1">MSRATRTYCSTRGVRRPHLSHYYCRQSAAMEDTQAVLYAVAAVLVAAYVIRWRTNPLNSIPTVGGPSAPILCYLSALNFLLHPRELLTEGYQKFHGSVFKVALIDQWLVVVSGSKLVDEVRRHADEQLSFVEGVEDLIQTRYTLGPEMTSDPYHVDIIKEKLMRTLPVVLPDVIDELTYAVPNYIPANETEWISVNVLKTMLNVVARVSNRVFVGLPVCRNQAYLDIAIAFTIDVIKDRTIINIFPDFVKGFIAGLTTNVKTSTRRAIPHIKPLLDERKAKIEEHGLGEPWEGKPNDMLEWILEQAIPRRCTDEAIVQRILLVNFAAIHTSSNSMTHALFDLAAAPEYIQPLREEIEPIVAAEGWTKAAMGKMWKLDSFLRESQRFNGIGLTSVTRKAMKDVALSDGTVLPKGSLIVTASYPIHHDNTIYENANTFDPFRFSRMREVEGEGMKYQFVNTSLEYVSFGHGKHACPGRFFAANELKAILAYIVVNYDLKIGGDGERPPNICFATNIVPNPKGEILFRKRKATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUR8</accession>
    <name>A0A4Q9NUR8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1040304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUR8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="254" mass="27766" checksum="AB600F33BC57CB47" modified="2019-07-31" version="1">MAPPPRAPRRKACEALLPDGTTPCSATFRGWGRYCAAHLEEHARLAGRYKDAAARAERLRAKGALGEKQVRAMVLESVVGRALQRVRAYRDALGEERAAREAYLRRFPVRAREEGEGDGGVGSRAGSPGSVQSDGGGERRESSRGSRFAGDEQHEQRLAALNELQAGCDVLIEQLERRREEIVAAAQQRRAGREAAQGDSERQPLLAGATPRPRIGWFGRAWSIGLFVILSVVVSTLFMLYALGYIGTLNHAYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWZ2</accession>
    <name>A0A4Q9NWZ2_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_879640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWZ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6249" checksum="5EBAB010FF0C1D01" modified="2019-07-31" version="1">MDLIVTVHLRRLMRRLETCRAAGTESGSNLMEVHSLAEGPSRYAAEDKLLDSVFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXI8</accession>
    <name>A0A4Q9NXI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_927178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXI8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXI8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="268" mass="30561" checksum="71BBE39559B81613" modified="2019-07-31" version="1">MPPSPTRARRSTTNGDLPSFMRRPPKPEGVKTILASASINNLTPSELEERYRHNERILAETSASSSHFIKQLEDQQSAIRARLNDLGVESIRSQLEHTKINEDESMTIDPSPPPPPQLEEYRPIGAKARALARWNPTGPRGAPAGGMSYDEAANILRESYQREQEHKARMNDRRRRRGDVVPGEQLTRAEMDARMLAFLTYKPTDSDLEDDDEEDEDEEEEGRPAWFDEDDQDDGIKGQDIVEPDYEDLSTIIRIDEARIPWAIPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYN7</accession>
    <name>A0A4Q9NYN7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Endosomal/vacuolar adapter protein YPT35</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PX domain-containing protein YPT35</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_920823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YPT35 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYN7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NYN7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07280">
        <property type="entry name" value="PX_YPT35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037917">
        <property type="entry name" value="Ypt35_PX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="212" mass="23408" checksum="144C7EF42CAA1074" modified="2019-07-31" version="1">MISTPSSPSHSAESSTSFSRQPSDGSDSKGLLVLIPDRIDIEEEAQFYDDIVDSASTTGQDIYPFGQPDSPPLSPVEARSIFSNDIWLGDNSGESKAFARGVEIPGWTSVGDKRGGAYVVYDCAIRTKEGTVIHALKRYSAFAQLYARLRATLPASQQPFIPSLPPKFPLAKFRPTFLDRRRRLLQHWLSAVLLHPEIGGCQAVREWVVDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZE5</accession>
    <name>A0A4Q9NZE5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Snare associated Golgi protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_944472</name>
        <name evidence="9" type="ORF">BD311DRAFT_653476</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZE5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZE5"/>
    <dbReference type="OrthoDB" id="3364966at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045014">
        <property type="entry name" value="TM41A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43220:SF21">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 41A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="8">
        <location>
            <begin position="235"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU63946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="463" mass="50013" checksum="590BE00D9E5C4045" modified="2019-07-31" version="1">MASSLCPPVPPPNRHRASSTNVRPPLTLASLGRRRSSSLVDRPSTGEPGLSPIPPTPRSARDFPPLSLSIPPLRSPREIPSPPSKLVSMVSRWAHTLHLSAEQSFPSTPSSPLHSRASTDDSSILPMSSSPTRSYFGDVSFPEKPQAKAKGRLWEGHPSVHTPVLLVLIMFPLSSALVVFCMSTLPITSAWPRTLPDLAQLGRELHGYTQSGLFSIAHVVGVISVVTIWMHSWSIPGSVLANVLAGALFPAALSIVLLTLLTTLGSLSASALAAPLGPFLTQFFPRPLAMTRSVLEGGDSSKDNSSPAWVRLSVLRLIGVVPWSGINIACGVCGVAIWDCFLGALIGSLPWTAVTCQIGDILQTLATNPRPTSQSVQSILTSPEIVMKLAVLSFLSLAPILGRNRLRAWLSKETPEEQQATEERWAWVKEWRSRIRSGSRSRAIARDARELEILVREKESLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2A7</accession>
    <name>A0A4Q9P2A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_665252</name>
        <name evidence="2" type="ORF">BD311DRAFT_42392</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143489">
        <property type="protein sequence ID" value="TBU24012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2A7"/>
    <dbReference type="OrthoDB" id="2755037at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU24012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10522" checksum="669F71F4BB3BB13E" modified="2019-07-31" version="1">MVHTRKAELVPASSFSEPSEPSQLRPDDKPKEALAGEQEENPQLVAHKEGRQSGDAKGVNARSRARGGTGVGDAKDVDERKRKDVAGGFGVAKEGQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P474</accession>
    <name>A0A4Q9P474_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_928847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P474"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="239"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="711" mass="79039" checksum="A09FC07727270764" modified="2019-07-31" version="1">MRLLATLTGELVQVRSPEDVRYAILSHVWSEGGEQSLQDLERIHAEVSAAQEADPTLPKSTPLDRMSPKIRGACAYALAEGFDFIWIDSCCMDKTSSAELSEAINSMYAWYSKATVCFAFLHDVPMMQPRSAVLSRFRQSVWFTRGWTLQELIAPRRVIFVSAEWRTIGDKSALSGIIEEITGIDGDILRHSRPLHSVSVARRMSWAARRVTTRKEDEAYSLLGIFGVNIAPIYGEGDRAFIRLQEEILARIPDQSIFAWNLHLPLSLHPHSQTFHQASLFALSPAWFLSSGNIHAISREELSRRLQLRIPPATHSMTSYGIRTVLPIISITVHFHLAILACQYGRGVGRTMCLMLKGDFDGILVPISIAGIDRNISPADFVTASRPRIRPFPRLGRIRLTHADIHINLTPSEHPRLVEVHISRGLQPGFTREIIPPILLHPSGGLRIADTDHLATTQPAICGGPSTYCGIRLDPRSESELKREGYGVCYSRAARSAYLPDVHTFAFHRRRCSISISIFPCPCSREVPRSGSKTPGTEQTMKSLALSLTVTVTFPLSTYRSKAVPITISGDAFDPDGNYVPVAHDWRQPCHRKGPIPTFQDTFTSQEFSFKDSSGPRAHPFLELQLDRDAPQGTHASTTFTLAAHFNAEPRPMLVPLRWHVPGPTPCVITEEWEESSGGLLRGRTTTHTCLEPASGSLSQPVPLTQPVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P656</accession>
    <name>A0A4Q9P656_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_816738</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>melleolide F + FADH2 + chloride + O2 = 6'-chloromelleolide F + FAD + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67160"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:167712"/>
            <dbReference type="ChEBI" id="CHEBI:167713"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:67161"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P656"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140907">
        <property type="term" value="F:flavin-dependent halogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="671" mass="73070" checksum="D2E02CB8FA211AD9" modified="2019-07-31" version="1">MPSADMPQHAQILVIGGGPGGSYTASVLAREGFDVVVFEAAKFPRYHIGESLLPSVRHYLRFIDAEDKVASYGFVPKPGSAIKFNQFMQEGYTDFVALGATNNAWNVVRSEFDHLLLKHAASCGAKVYEQTRVVDVAFEDASSSQVPLQPAPQPPHSCFGQRIPGQRRPSTVEFSNPPASELGRPKSVVYETAFGAKREITFDYLVDASGRAGIMSTKYLKNRKFNASLKNVAVWGYWKNTDMYGEGTSRQNAPFFEALSDESGWAWFIPLHKGLTSVGVVMDQKQLGIRSRASSSATNSPLPGGRRPSISARTASTLAGRYVSFLQLAPGVLDLIGDGELVAVKTDEDDGEEEPPVARSASDYSYSATEYAGPGFRLVGDAGAFIDPFFSSGVHLAMTGALSAAASIAASIRGHCREADAARWHSSRVSLSYTRHAIRCGVLDSTNWFLIVVLSAYKQIRAQSVNVLADIQENNFDKAFAFLRPVIQGGADMGTRLSEDEVQRALDFCVHLFDPTTPEQHESVRQKLEILRAPASPGAPFSTKSSTDSDVSRLFDVRAPLLDPSQLEQLLRRQLRVQVHECDSAPSTPPSPRSAYFPSSPQSPRIPAAIPEAGADPQSEIRMVLNKVNARRVIHAEHGNGLNSLEEEELGGYVLRLKRGELGLRKVEPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6W4</accession>
    <name>A0A4Q9P6W4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">CLP1</name>
        <name evidence="12" type="ORF">BD310DRAFT_911203</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6W4"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6W4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="10">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="11">
        <location>
            <begin position="138"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="9">
        <location>
            <begin position="377"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="141"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="498" mass="53844" checksum="E86008F25999436E" modified="2019-07-31" version="1">MMTMDTSENVSVHTRQWTLQPESEYRFELDPNTTLAIKLVSGHAEIFGAELAEGKAYIFGQECKAAVFTWQGCTIEVTGHPSVEYLSDETPMSIYANVHLALEQMRVRALAAVDGSPIPEDEGDDAIGIDPPRVLVLGPENSGKTSVCKILTNYAVRAGQDWVPIYVNVDPSEGGWAVPGAVSAAPITAPIQTSTPAATLGSAATSAPNHVSSNALLPLSYWYGHAEMRRNPLLMDRLIRNLGENIRDRYENDAEGRCAGLIVDTPSSFAASSSSSNDHRLTMIKACVDAFQINVILVVGHEKLNVEMQRTYGNRMAVLKIAKSGGVVELDAAYRERVHKYQLHTYFYGHVMQPPPGLPSKAYVQGGEQTPDQTMHLSPLSASVNFGDIVIYRIGEETMAPSSALPIGAARVVSEMQPLVVEPAIGGSGLYNAILAILAPPNPDESERYDEEILDLPAVGFVAITALDIPNRRMTVLSPSPGSLIGRTAIVGSFEWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9V2</accession>
    <name>A0A4Q9P9V2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145320">
        <property type="protein sequence ID" value="TBU51450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9V2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6432" checksum="93E2EF9D009AAB59" modified="2019-07-31" version="1">MARYQPHLLCSLFSKGSVYVEDEGFPRRLTLPLRHFVRGDECYRRSRGFEGELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAS9</accession>
    <name>A0A4Q9PAS9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial distribution and morphology protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Mitochondrial inheritance component MDM12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MDM12</name>
        <name evidence="10" type="ORF">BD310DRAFT_803204</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion outer membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="9">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the MDM12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAS9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAS9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21672">
        <property type="entry name" value="SMP_Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03104">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027532">
        <property type="entry name" value="Mdm12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28204:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26544">
        <property type="entry name" value="Mdm12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="37587" checksum="274B8A3DC8770141" modified="2019-07-31" version="1">MSVDLEWNRIDSSLASTLADLINRQLATTPRPSFIGPIEVTSFDFGSNAPDIELVDLRDIYRDFLEDDEEEEDGTHGAPVKVTEFPDDDGFEWVSRKAARGKGVGEDGPAYHLLPPHVRYGMGPGMGGMGMGMDMLHSTPFLRSPRDIWSPAFTSLADLRPSYPSPSLYLSAMSAHPNIQSHLHITWQSNLRITLTTSLLINYPSPMFMSLPIKLSVTGLIFNGEVVVAYEGERKRVHLCIVDELDPYGPLGSDPEEEAPVSAGAGGGTRAGKPLPIGQRLLPSIYIESEIGQADKHVLKNVTRVERFIQDVIRKTIEEELVFPNFQTFVLGDQEPEDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC09</accession>
    <name>A0A4Q9PC09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_940670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="34730" checksum="B7E70EBE40F0901E" modified="2019-07-31" version="1">MGSSSTSNSETTKILQYLPLHPRFSLFFCTFTTVSGLYIFDLTFGNFNDLARMINSLPALRRLVCNGVRCVSLGPLPFNKKPRADGIHAPARPFASNLRELSLLKVDIHCVQRLVSACGPRLSNLVVGMPFFNDTEMVLLGDPTTKHTMGVDLSLCSALERLEICLRPRALTEGRSLDKLKAMLNSWDPQVPLQNVHLRAYYEHNFTQQSFADLLGTVGLVLEDLLRESSGSLSADGEVGEQGRRWQLWVDINDWEVWRDWWWTHVQKCFPTLAKSAALRMNFALPPYDLYKWKDSHALPPMLTTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCR3</accession>
    <name>A0A4Q9PCR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_313358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145283">
        <property type="protein sequence ID" value="TBU51825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCR3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16723" checksum="7701D2236E2A65F0" modified="2019-07-31" version="1">MITKIEAGRQCGSHLGVYEGIVATAVTVLTGSTRKLRESRSRWLMDYAPGAAWRDGPGQKTIGYHRRGEIFTSTGALMAHTTGLNTAGLWPTRHVRTSRIAQRRRDGRTCLIGKAARRRGRSARLVLAFVLQVPTRPLAPRASATFPEARGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDG6</accession>
    <name>A0A4Q9PDG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_939685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145240">
        <property type="protein sequence ID" value="TBU52708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDG6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDG6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27836" checksum="CC77B6BB9A9D36A8" modified="2019-07-31" version="1">MPLHPPTNAYLPEHNNVVLTKELLLTALNDLSLRLAAYFPSTVRLVVHGGAVMVLHPLLACRESTRDVDYIHRSFEAEWIARGVTDAGARLLTCIKATARQYNLGADWMNACADRALPVSLDIYGRPQDPISCDALSATNVSLNTIYTSPGLVLVGVGWAWAVALKLVRYDKHDPHDVASILRLGCRQRNVQWTRTLLEAWLVSICGAMGYAAYSPWQMEATRQKMRHAISLAHSQDVAPHDPGLQAVRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE27</accession>
    <name>A0A4Q9PE27_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_834227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145315">
        <property type="protein sequence ID" value="TBU51497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE27"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="12"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="300" mass="34175" checksum="7869BFF0CB56F7C3" modified="2019-07-31" version="1" fragment="single">QARFLNRILSSVAFSLLYYEYVLTLPLEVERYWHSAWSCASVLFFLNRYLTIFGHIPVVVEFFGVFPQPVCRLLISVYHFESNCSRCRQLQQYHRMSSALIQGVVAGLLTLRTYALYNRSKKVLASLLLLLSVAVAITLWTIIGNRHAHRPQPTDALATSNGCDLTLSQQEGYSLALAWSTILIFDAVVFVLNVFQTVRTGWHWRGGYLRIMFRDGAVYFGILFVCYLSNILAYAVRAISIGYPVHKGVSTSLTNVLSSALVTRLMLNIRDLRIPDPAPRMIGDDMEMSNKSTIVWRRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE72</accession>
    <name>A0A4Q9PE72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_938977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145229">
        <property type="protein sequence ID" value="TBU52998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE72"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="356" mass="38878" checksum="0E009822377C655C" modified="2019-07-31" version="1">MFKRVERRILKKEKEEELGLDEETKEMLGLNAADTDSDESESSSDEGSEEEDFLGAGDGEDASDTEADVMDQDEEPSDLGEDEEDEDEDDGVSMTVSESLQNPLWHVSLEPEVKACAVCPGKILKNPVMVDVHINSGAHKRRFAKLREAAIDVDPDTDIRDFVRIQRLSSQPQKQAAQGKLSKRAEKKKAKLAAIKAKRANQKLMKAKHRAKKEVKEKTAAEVDGASSESEREADASPAKPPAVKKRKVEKSSISDEAVSAKAVPAKKQKPPAVKDGADFKRKASPNAAKAIPKSKKQAADPPRDSDKPTAKFSATQSSPANPSEQSKRKSTVATSRPPLPKDTKSKKRRRSDTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PER0</accession>
    <name>A0A4Q9PER0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_317554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145290">
        <property type="protein sequence ID" value="TBU51727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PER0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PER0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="15618" checksum="B195AA888EE08560" modified="2019-07-31" version="1">MKVGIDEGAPAGKPEGTDVPLGWWPWPWGLLPGKPLGAPEGMGKPPEGRPDGKGRPPEGKPDGKGRLPERTPDGAPEGRPLGTPDGKPEGAPEGKPEGIPEEEPEGAADGKPDGKPEGAADGRLDGMAGTEAEDGRATEVEGSTGTAAPVQGKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PES2</accession>
    <name>A0A4Q9PES2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_167312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145220">
        <property type="protein sequence ID" value="TBU53238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PES2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="16"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9808" checksum="CB8578925353319F" modified="2019-07-31" version="1">MAVSLQDLSRTVGRDYTMASAFVWLLFEYFLTLDQEVELFWGQKPTVASILFLSNRYLPLLCSAWWTPWWSSSSSYGVSTALSNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEW3</accession>
    <name>A0A4Q9PEW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_963038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145312">
        <property type="protein sequence ID" value="TBU51521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="366"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="787" mass="89624" checksum="0AF48047706147C1" modified="2019-07-31" version="1">MNVHTCIIAGFESFQYSNAPKSDESNEGYTASEDQGYYDTPQDIDQDFLANHLRSPTTFVATHSMLADVAKIMDAVTDNVMRREAAASLLNSISKTLHESLSPSTREKHRKRSRVPFGKLGHLTFVVNYCEKEERDAPELVGVYNADDLRGQDDVDGMHHRIPYHRIEALVEVKPDRRRGGHRQTVSCAHRHHVARPDRPAIYCLVIEPGWYQVISSDPTGVVVSPRNEWTDLRLLAAYIYSHYYPPRDRHLWDDSVSWISGETPHDPPTWMVRCHGRSYTHGRLLFAGYPWGRRTTVFQVTDRQGSEMIIKDTYRRRVRRCKEQYILVHIHGDGDLPGVVRLTWAGPVRTGNKMLTYGARGDEEARRKERMALLDSGCSLVRAKTVNDLLEAIYDVLEVHRTVLRERKILHRDMSINNILMYPKRADVGGRAMSRKAPLFIKDVLGGSPRPRTERLPACLVIDYDYAAQIEDVDELKQRTGTPLYIARSVSLGMVLLNHLSVRGKPMPRLTGGASYLYTSAYGQERYDRYNDEPGSPTCHGGLPPSPDPDDFDETRLPPFFHRPEHDVESVYWTMVYALLRVQPAGASRELDLSAASASVWKTLLSHYIPGEEYDQSDEKRHEVMSRVKQQWLDLFGATMQDVALLLWRVTQHVRAEYALWKWEGNPQPDHLHEAVQRLILQYLVDHRDNPIQLDPDHLRPTHPRSTNQGDTPTPTQLSWTQANGVTGNHTASRVGSRRAASGNQGSDEASRYRIIANLKRKLSDKKPFRSSKRLKALSGAPMSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEY3</accession>
    <name>A0A4Q9PEY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_952039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEY3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="285" mass="29791" checksum="9CB4E1BEF02FD2D2" modified="2019-07-31" version="1">MSPASTSHGPSTPASPFSASFDPNESALSTQASLTTPLAIRQGPFYPSGDVQLRPAGPDVSALLAHRLSASFGAIAEQIAAASRALAVPASNAAGALEAPSGGTGGGSPSQSAELAALETRLGIVERAQEQLSADVQQVQAELLRLNGVGSAHGEKEQGEGGIVEVRNGAGAEGTGEFKSATEMAIEELQKKVEGIIETIKLDQARLYARLHNSTVTSNKHPIQAPVTANGKVPQNFPNTKGEFEHLTKERYEHILNAYNVTPKGDTKAKREQLREFIGLTPPTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF63</accession>
    <name>A0A4Q9PF63_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_991307</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145209">
        <property type="protein sequence ID" value="TBU53604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF63"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
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            <taxon>Polyporaceae</taxon>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
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    </evidence>
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</entry>
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                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
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            </authorList>
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</entry>
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                <person name="Riley R."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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            <strain evidence="1 2">CBS 464.89</strain>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="225" mass="24293" checksum="7122C46172623528" modified="2019-07-31" version="1">MPKVAIVMPARVKRLATGTEDVISRTKMKGVSAKVSMRGERKKIVSWQKVLESDGVAGMLVLLHPTTPPSSIDTTQHHAIKTYRSNGASSSNAPSLSLRLLSAAAAACSRVTCLTTAHNCLGRFEYIASALAAVFIYATTTVEDFGGETDSDTAQPAAHGIGVVRARQRLCGQRSVQTVHVPSRRHFEDLARVAQHLRQLSQGLSSPARLSPPTIIELAEEVWER</sequence>
</entry>
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    <accession>A0A4Q9PHZ9</accession>
    <name>A0A4Q9PHZ9_9APHY</name>
    <protein>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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        </location>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="552"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="176"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="709" mass="77904" checksum="B5A74779ED71C610" modified="2019-07-31" version="1">MSSLSPHDMSSTLTTSTPISTPGRGRGRGRGRGRGASSSTHLSPGKAPTVEHDVQGTLSIDNATPTGADDLGRRVEKRGHPYGTRTSNTDRNPGLYPGLKWREDKAENARKVAETQAKLDESTKRKAAKVAQHEREEAGSRRLAALEDARYLEEQEEEAYLGRTTVSAHNSRREGASSAPTTTADASMEVDDQAIGHHGIEGTFAGIYEEPEDEYEERASEEDETQSRQLRRKSRRRNEVLGKIATSRQLNVEGVHISEANTGTPAKRRAEDVEGGKRPPKKPTVSAFNDDWAALSPAGSRLLSVAHPPSSSNSRPSSISRTSSRAGSQVDTSAHDSWKAILLSKLGPPASHGVGMDEFLQGSKTSQSGTVVLEEEQIGGLQDDDIEFERPTGTAGSAGSWNTSSTPTVEFYGEVSSLTKTKRTAKRDMPEEQSLSADNLPGWIKPVWPQVSASLCAFYGAEENPWVLDRNEEDPAHFDNVLKVLLDALFPEKHYIADSSDQVYKIARQAIYNWRRAFANSARAAVKQAVKARHGNPRQVTRESVAAWAKSANSHGGEAHWENPDTRKDGEPSGALQSRYMLQSFAGHVRRTEKSLFKNLGLPIGALTLACTAVDYAFRHYYTGVEAAPKGLRRFDYDTVGHMMEEWYELTVKPLADTKPHRFKALVARAREWGRAQAVSNESDFRSESTQPERRRPVLDRDSSPALPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ17</accession>
    <name>A0A4Q9PJ17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD310DRAFT_886796</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="ML145198">
        <property type="protein sequence ID" value="TBU54071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ17"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJ17"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043687">
        <property type="term" value="P:post-translational protein modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12610:FF:000001">
        <property type="entry name" value="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0464">Manganese</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="20">
        <location>
            <begin position="23"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="21">
        <location>
            <begin position="574"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00059243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00067960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TBU54071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="780" mass="85789" checksum="BADCC449202A7577" modified="2019-07-31" version="1">MPLAYSLPSDLSPATVTNTSSLLRIIALALISGAAIASRLFAVVNFESIIHEFDPWFNYRATKVLAEKGFYAFWNWFDHTAWYPLGRVVGGTIYPGLMATSGVIYNVLHALNLPVDIRNICVLLAPGFSALTAWSTYMFTKELKDESAGLLAAAFIGIAPGYISRSVAGSYDNEAIAIFLLMFTFYSWIKALKTGSAFFGTLTALFYFYMVAAWGGYAFITNMIPLHALTLILMGRFSSRLYVAYSSWYAIGTLASMQVPFVGFQPVRTSEHMAALGVFGLLQIVAFAELVRAHVSSRQFQSILFGSVIVIGVLGVLAFAGLTYKGWIAPWTGRFYSLWDTGYAKKYIPIIASVSEHQPTAWPSFFMDLQFLIFLFPAGVILCFRELRDEHVFVIIYAVVASYFAGVMVRLMLTLTPVVCVAAAVAFSSLLDTYIDPVEPEVSEVAVPVTGGDSSAASPATVDGAVSSKKAKKAAAAVADASSTGIASGIVAAIGGQSKSPKARGIFGLDTRFLIVVNALGMLLFFVLHCTYVTSSAYSSPSVVLASQNPDGSQHIIDDFREAYYWLRQNTPQDAVVMSWWDYGYQIAGMADRPTLVDNNTWNNTHIATVGKAMSSPEEVAYPILRKHDVDYVLIIFGGLIGYSGDDINKFLWMVRIAQGVWPDEIQEPNYFTPKGEYRIDDAASPTMKNSLMYKMSYYRFAELFGGSQAVDRVRGQQVPKTGPTLDYLDEAFTSENWIVRIYQVKKEDLLGRDLKTANAFANGKKRKKSKPLARRKALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJD9</accession>
    <name>A0A4Q9PJD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_99733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJD9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17596" checksum="9A9AFF8D2A315EB2" modified="2019-07-31" version="1">MNTEGRDRGCITLHRATTQSPPGCHSSEARETYVAAHVRPYTGWSDPPFNDLSVPIGSRAISGLRSLKRRCPAAKLQCSGSVEELDPGIDFVALNVEHCRRGLFTLAHRFFLASLPILVNSFPLICHSAYGFYRYQAYEVPKMLRKYLGRALNMHAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJM7</accession>
    <name>A0A4Q9PJM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_909019</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145192">
        <property type="protein sequence ID" value="TBU54307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJM7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJM7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27913" checksum="130420E882FC2DB0" modified="2019-07-31" version="1">MGNPARVRDLGWMPKATKGSSKKPASAPFGSKASSKTQKNPLFESRPKNFGIGQDIQPKKDLTRFVKWPEYVRLQRQKVILSQRLKVPPAIAQFSHTLDKNTATQLFKLLNKYRPETKQEKKARLDALAKATAEEKEAQTKPEKKPLFVKYGLNHAVALIEAKKASLVVIAHDVDPIELVVFLPALCRKMGVPYVIVKGKARLGTVVHKKTAAVLVLQDVKSEDQRELATLVSAAKANLYALSLAFVYALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJY3</accession>
    <name>A0A4Q9PJY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD40-repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_858614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145189">
        <property type="protein sequence ID" value="TBU54433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJY3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJY3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="707" mass="79045" checksum="CC6A5D3093B89F59" modified="2019-07-31" version="1">MSASPRLAWELIERIISESGDDTETIYSLSLTCRQLRPRSLCHMVADVDIRTRKQVTAFRDFLEAYPQFCHFVCSIRADPTTFMPFPLLNILPNVISIEWSASMREYHRVGLSLPLRVLTCYHKFGTNVTSLSLYSLSFKTWQELCRVLLAFTAVKELRCEGLEVESRAINGAALEQRLRSQGLKLRTINIADGVPEAVTKLLFELAQSTVERLALHVYNITSLSSDLLCEKWPELLTLTLNLKVFPRSNGDDNGIEASIIILKGFRPPRLDEVTVEIQSTVGNLLLWIGSDERNLHLCSELDQTLLSYRRPQLLPFGHRRTRSWRKGLWSEELGQYFPRLRERGSLQFASSADIALGHDELVTSLVYCPDGSRLATASMDCTIILWNSDGQLVHEWVAHTRAVYSLAFSPDSRHLASGYADGKIAVWDVSQGAQKIATLEGHTKLVNHCAWSPDGTLIASASRDKTVRLWDTPTFQQLHLLKVSTNDFVPVVYFSSNGRWLVSPSSRRCYVWDIASGAMYKDFCIAEGDDNGDQAVIDEENEEDEDVGTWCCATALNLQGTRFATGYPGGSVRIWDAQTGQCLVVSRMHMDRVFRVAFSLDGARLLSTAWDGTAKIWDASSGAMILSLEGHTEGIRAACFSPCGKYIASASFDKTERLWRTEDGSCMGTFSEHKAWVMHIAFSTDGKTLSSGAHDGTVVIRHMGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL39</accession>
    <name>A0A4Q9PL39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Gpi16 subunit GPI transamidase component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_935022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL39"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL39"/>
    <dbReference type="OMA" id="NHGHYIG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="567" mass="62931" checksum="13561447F8053B24" modified="2019-07-31" version="1">MRWNICSKTSLLLAFHVATAFALHEQFDEDLHLRPLRDGKLLSRFSFTTLLKGATPRDPQLLSVDDEAQHYTLFPLALGQVLREHAVTELHLSLNAGRWNYEAWGYPDEPGVGTGAELWAWMGDSTQTSVDQRWQGLRNALAGLFCASLGHLDEQRTTSPSLTFQPEGSLPNFTYPHRLRHATLPSEHVCTENLTPFLKLLPCKSLSGIASLLNPHRMFDADWHGLGVHVRYREDAGVEVRLTFQAVFDPVRSSNDRRRDWSLRSTFDRSIERACPVAHSSKVRVELPHGPSPYSITPEPTGISDSVATYAVDASDEALDVALRWPTEGSFEYPNTSKVPPLTDVSVRRTLKGTSQAEAQLTLVITNNLPVQVSTGYLETMPWHLQFYLHTLKASVNGAARDDLVSILSYMPPVPHSRPALLQAVLTLPPSSTLHLTMDVLKPFLRYTEHQPDAQRGWDLPPAVLVPFAFGETASQNHTVSQPAGTIQGSLVRPRRIYTSILLVDLATPDFSMPYNVIILSCTLIALLFGSVFNCLTRKIAIARVGPTPTSAARQEDHTPAPEPQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMP3</accession>
    <name>A0A4Q9PMP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_682659</name>
        <name evidence="2" type="ORF">BD311DRAFT_672810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143491">
        <property type="protein sequence ID" value="TBU23950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMP3"/>
    <dbReference type="OMA" id="LLMRFDH"/>
    <dbReference type="OrthoDB" id="3167300at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU23950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="38289" checksum="1D01AADA1336ECF3" modified="2019-07-31" version="1">METFTRQAQLPTELLRQIVLEYVSTYDEGRKFEEPRHSYKPPWSSVEPLTLASKVLRQLALEAWFEVYYVRTPDDLLHAWPEFELWTKELHCVELGTDLRILPVQWDFRAFHRLRKLRIDFDPMQSNAMLLMRFDHPRHIASQIQELEIYDISWPSPMAIHLIADAFPRLRTLKLSQDLMWCNLCNICRFSTFRDHPPEEITYDKSVGLPSHYATYLRPLIKLEDVVLTVGYGLGGSYSLSENNGILWTGECDACMDMMFSVGDFRQDWVEKKKTMMRPPSLKTVKWRFRYKNVLDVVVDLDEDEDEVAQTADESDAGNLTIPGSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNX5</accession>
    <name>A0A4Q9PNX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_883578</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNX5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNX5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24121:SF23">
        <property type="entry name" value="NO MECHANORECEPTOR POTENTIAL C, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21411" checksum="7AAF6107C3F29122" modified="2019-07-31" version="1">MSLATPTSEDLEELLLSARYGDVDDIQQFVDKFGSDAFATVRDDSGNTVLHMVAGNGHTDALNFLLPLVPSSLLAARNNAGSTALHWAALNAHLDVAKKLVRFPGGPGVDLIDIKNATGRSPLGEAENAGWEEGARWFVQVMNLDENAKSEAVDEELQSAEGVDRVEVEIQDAEGQVAKTVFGTNETDSKSVCAGARAEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ65</accession>
    <name>A0A4Q9PQ65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_609440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ65"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16874" checksum="C989F10D7B8685A6" modified="2019-07-31" version="1">MRRSRTKCERETMKLPTLRPPCRSRVRNWQGIARRCRCNREIARSRFPVNDAVGRAQLIQSYSTGRVAGHAGEERSSELPSQPLGLFMSVAVAEIFPEANVSEACVRHVLTVSSSFGRYESRWEQNVHNMDPQRQSIRVGYLHFLNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQC5</accession>
    <name>A0A4Q9PQC5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_960111</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQC5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQC5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051026">
        <property type="term" value="P:chiasma assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03281">
        <property type="entry name" value="ABC_MSH5_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF20">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="6">
        <location>
            <begin position="805"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112636" checksum="A77505CDBDE9B9CB" modified="2019-07-31" version="1">MVLALLTDLRCPRGHVTGHDETRRVWATAHRLPSILLSPAHAPARKTMPRLTKSKRLSVPHTSALEEELEEETTALEASQTDDTLPRKRVRWEGSVDTPEEEEDQQVEEESSLSGTAEKVCLAATCQSGRVACAYYDPVKCTVLVFDDSPEDHHLDLTKALLEKAGPDVVLTSSKADDNFIEVLRNHVDGSRGTFQVRPHKDFIPLKGRDRLLSLRLLSQLPVYQNDQDTTSELGSISEPRNAYDFMRRRRETGGDPMLQKWNASVRLANFASVENSPLCLGSIGALLDYLARARAVSDLEDEGINGLEIRSIEPLLLTDTMQINMDALFSLQIFEDENHASIHSDKTKEGLSLFGILNNTKTTLGRALMREWFLRPSMSLEVINARHDAVECFLRPENITTRNAMQGHLNGTKNVPRILGAIRTGKAKVSDWQALVKFAFHALLLRDALSELKHAGSVMIVRKLIKALDVSNFRQLGSAVNEIIDWEESTNTGRVCVRPRIDEELDNLKHIYNGIDSVLSKVAVQVSATILPDYTPSLNVVYFPQLGFLICVPMKEEWKTDAGITVPDGWSFQVIIMPRLRLACTGSTTLISSLLSSSHVYFKSQEMHDMDVHIGDLHPAIVDREIEIVQALQEKILVYDEIIGHACDVCAELDCLVSFALAARSYDYRRPYMSTENIIDIKQGRHPMQEFAVPTFVPNDTYIVGGAGIGVTFPDDETETESQEEPHNVKNSVMVCTGANACGKSVYLKQVALIQYMAQSAILGVVDKIFTRVQTRESVSRVQSAFMIDLNQVSLALRNSTARSLLILDEFGKGTLPTDGAGLFCGMLKHLLERGSSCPKTIATTHFHDIFHNNLFSPCRVPVTFVHMQVMFSLNQGPGALESREPSAFIEYEDDGSQTRMGPDDKIVYLYKVVNGYSLHSHAITCAELSGVPKRVTSRAQYVNELLARHEVCQLLDEDMRDEERRELADAEEICRKFLAWDPTLPRGGERPTPIRDELAVMLDRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR01</accession>
    <name>A0A4Q9PR01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_882021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR01"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043848396" evidence="2">
        <location>
            <begin position="21"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="19654" checksum="63F845ABA504F934" modified="2019-07-31" version="1">MFYIRALTLTASLAIGSASATSPATQTIISTIAGHWMTIIEDDAQDTEPYTGTVDQSQIFPSQRRGTLGGRQLLDPEARRETGDREQEAGKENRTTLPPIPVQDRGPSLLTEVIEESPVAEVEESAAFSGPLPPSHMESRFVTESGSTMDGTQRTMSHSAFVLAPALTAALLLEADGTPDASRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS40</accession>
    <name>A0A4Q9PS40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_563978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS40"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18816" checksum="FB080B67DC714051" modified="2019-07-31" version="1">MRGREDAPNSSISLNGRSRGALSKNIGSEAQPRRCWNPGVKMASSRNERHRSRPPTDTRALIYPYSTVYIRSIVCTMYGTRLHRPNANPICARLPSNFFRRMLQCVGTDQFNAQPCDAPRPTPRDPSHPSLTGDFTGQALASLYPLQLRYFAAGRGEARVGRATNVDSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSY8</accession>
    <name>A0A4Q9PSY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_538937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSY8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7851" checksum="C98441A78A241AA6" modified="2019-07-31" version="1">MPAMRLLTAIVPITVARRTAHMVVGLPTGASVLDRRAERRSCQLISCPPAEIVRGSVQGRHRTVTQSDTRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSZ5</accession>
    <name>A0A4Q9PSZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_539523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSZ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="371" mass="38892" checksum="80DB9117664BC22C" modified="2019-07-31" version="1">MEYVQCVQFDGKEAIWGCIPVRCGADSADGYNICTDQPSGDPATTILVTGFGISLFTLLPTGIPTRSLSIQPPPTLIISDVYYSPYTIHLAISPPTTSRTLLSSTSSTRSSTPSNTPASIVTTDNINPASDVHSNTISTTTTSPFGPTASPLSASMPSSTSSAPVQTHPDSIPAHASASHPGMRTGTIAGIAVGAVSLVIACAVLFVWLRRRRRRPTRLVGGATPDLETATEEIRPLSLPFPLQPNRRTQSLATLVIESLSDNDGSLVPQAVSGLGALVPLEPSTSMAPIMSEKRANSTHRIAGPVQYPAETDSGASTNRANTHTEGMRRHETDGGVRLAGGRAGDALDDDPDGRRDSVESTLPPPYSDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT89</accession>
    <name>A0A4Q9PT89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_928774</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT89"/>
    <dbReference type="STRING" id="114155.A0A4Q9PT89"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="441" mass="48906" checksum="F48B35AE3D7BA8FA" modified="2019-07-31" version="1">MVNTRDSSSRRTRSASKDTRKEPRPDPKPSRRKSAQAKTTDKARRTKSVGARATKPPGRATSSQGSVLSSPPRTQSMASSSTATRTERERKPVEPTLASTRTRRGSVIATPVAEPASNRNVSSRTPASLAPSRSVRKRKIEEVEVVVSPPKRQRGNLGDGEETDVRSIVERLQADEQALRKRELALKKREAAVEKMEKKAMEKAEKVTKMLKRIRSEKLAVQAQVKDMQGRVEALTAMITTLENKCRERNAEVITSPASSPGGLDTHWVLTQLEDQFQCSICFEVMACPYQLNHGLCGHTFCALCLLQWCFAAVHRGCGYWHDALECPLCRAELPYTPDVTPRQMCTLPFVPCRLADTTIKMLLGLLKDAAEADINGRGACSGANPKLDDRVVAWSRNGNSRVEWESRDARGRAEMTLLVNNWANLGGEDFVALKDRLDLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUP6</accession>
    <name>A0A4Q9PUP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dynactin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_879565</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUP6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUP6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="27"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="80"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1138"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="293"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="973"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="99"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU58180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1256" mass="139402" checksum="7C3FF0A64D066DFD" modified="2019-07-31" version="1">MPPAGNEPTLGAIVEIPAGRGVVRFAGATSFSAGKWIGIELAEPNGKNDGTVQGIKYFTCKPNYGVFVRPSQVKVIAAAPEPSQAPTVARAVGHQRTGSLSRTPSSRSIPSPRAASPAKPSSSALGNGSALLSPGGRTAAARLGSPTKPRPSLTLQSRPSLGRLGSLQPDVASPTRSARLPESPVLEPAPRIFPKSHGSPGQASPQPPQPSSLRRVSSPAHEDPEPEPLEPPEPLAPKLPSRPTTPVRVVDDTELQELRAKVRVLEAKRADDARHVRELETRLSEAESFVALRPKLQAKLNQQQTELIATKRELADAQQLAQLAESRILDTQEQLEMSMLDKEMAEERAEVAEADLEELREKLAILEVELQHLREGRDGEEGGGESNVKQSLAYIQLEKQNERLKEALVRLRDLTQETELEQRRRIAEMEKDVTNLDEIQTQYEATLGKLANAEVQIEDLKAQLDDALGAEDLLVQLTERNLMLGEKIEEMRITIEDLEALKELNDELEENHMETEKALQEEIDAKDVQIHEQSRKIQGLEEACQDLEGTIVQFRELVLSLQTELDTLRAETQTAQHESATAASQTAAMMSLNLKLQSSASKNQARHIDLEVKKIEAREARELLNIVQPYLPQIYVESDMDATNCYMFFQRLAAKVDLINAVVAQTHNLPEALNGPVSDVLVGICEMRGRLSSLSTTCKRFAAILRKCDVETFLNVGRIYPDLAPMEKRIDMHVDLLRREEFRELECVSDAVKMQSQFDHLSETSFSNFEYDLGERELGYALAFDHDLEMFAASVGLIKTSVAAILKDNDVALDLGGMDAQAEFFEPLQKALDQCRSAKVLSKKLIKRVEDLTQDSMALKAHLVPQLQNLNNTVPELVNFGISLAQLVMPHISDVRAVKSAFQLSTVVSYVKQSAASTVGKAGNEESASWDSVCEFLAQVIQEANRIVPMSLEAENTLKITGTAPWILRIDDIKAATAVNVEAERKVAQLNDEMQALARTIRMKDQQIQETGVKIELMERRMETVKKQADTITDLENELAKARKQERAYEEAMEQLQADLDALEQDNAKLKALANNPERQASTTTQVVEAETVPTEGNFETSYLLEQIDSLRGTVRFLRQENFFLKGQDLLKEIETLPELPAPIPREPTPELVPSTLSDSDSDSDDEPRQPPTLRSLAVESKLLYREVIKYTSSPRLVDLSVLKANRVNGQPTTKAWLPRKKTPAYQLFERKMQGERLGKRLKGLLELTNHIADAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW35</accession>
    <name>A0A4Q9PW35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heterotrimeric G protein alpha subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_948426</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW35"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW35"/>
    <dbReference type="OMA" id="ANSHWFK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000051">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF242">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="199"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="268"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="40563" checksum="DA9F2F0E7D66AA20" modified="2019-07-31" version="1">MSQGGIEISEEDKRLHREAEKSLKEAKLKMQKQVKVLLLGSGDSGKSTILKQMRLIHRVPFSSQEIESYRQLIFNNLTHGLKNVIDAMEDMELEVSPENQDLVPIIEDASDIKDGEPFPTEFHEILKRLWEDPNVQAAYARGNEAALPENLLYYFADLDRLFDPEYVPNEQDIVHARARTIGITETVFTLRDHDMLMVDVGGQKSERRKWIHCFQDVTSILFLVSLSGYDQCLVEDKDANQMQDAMTIWDSICHSQWFKQTSIILFLNKNDLFEKKVQHSDIKNFFPDYDGEAGDAKAGREYFKKRFARLAQKANAKEREIYIHVTTATDTAMLRVVMAAVEGASQLILVVCPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWK1</accession>
    <name>A0A4Q9PWK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_948271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWK1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="19138" checksum="F3180FA6C769DE44" modified="2019-07-31" version="1">MPEDPTNLEKNLSQSIAALLVRTLYGFDGTRELRISGGFLMNFLPILRLAPSFVLFQRKLARWCLVNIWLTKWFSNWGERDAYPCMIGEDIAPSAAYMAVPLVNAAGTDMTMSIPQIIILAMSLNPPIQAQVQAERDAIVGPDRLPDFSDRESPVYLDAIIKRAMRWIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWK8</accession>
    <name>A0A4Q9PWK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_434937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWK8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5826" checksum="45B4EFDF515C577C" modified="2019-07-31" version="1">MSGSPRRKQRAWRTILIGLVEVVKGRQLKHTEVPGRRRVNTELCTPASCRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX19</accession>
    <name>A0A4Q9PX19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX19"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18527" checksum="F6D76E2DFFDD8D13" modified="2019-07-31" version="1">MIDASQSRSHSSALAAAAHGGSCWRCWGPPSFHIASLPKLETSIAKLFDPCSLALCGALSLRAARSAVRHTRYYEEPVCVYDIADCTPPTTKSPRGPLVLTGSEARMAGRARASSPSDVIDSSQTRWRPGSCWRLSGPTAWPVSVPLRTPSPRRQGCRLQRTRSLLTACYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY96</accession>
    <name>A0A4Q9PY96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_816874</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY96"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF6">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="9">
        <location>
            <begin position="66"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="45036" checksum="2324D7A221F3780E" modified="2019-07-31" version="1" fragment="single">MNGDLAGTQRSFLNVGAPEEPSAHVPTEQVSQETAARTEHDAQSPGNRRSRRKSEQLARKATIRVASLNMNGFGSLQQDHDNNKWGRMARVLSDSRIGILLLQETHLTAERLGSIQKLHERNFEIFSSAHPSAPGQREGVAVILNKRLVSIEGASATTIVQGRAIQVSLKHKGEDRINLLCVYAPTSEGSEERKHFFDQVREYYCAHRNVPKPDLMAGDFNNVEDAIDRLPISDPPDSSVGCLDQLKSALGLMLVDGWRETHPSSRGYTFHRGSGDNAVLSRLDRIYVREPLYRLARDWKIEESGIKSDHLMVSVQLTTLNAPAAGHGRPIFPIPLLKDKQLAKSMKDRGMKAAKILKDLESGMLSRTESVNPQWILVELKKDWLKLARDREKEVVPKLLAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ33</accession>
    <name>A0A4Q9PZ33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_359432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ33"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11115" checksum="F0A39F45300E1BB9" modified="2019-07-31" version="1">MLCLLRYKSNICSHHPSARRIRSPGRIVFVGAAFPTSELINSKSRQTFGGRSAADGRLSGTNVIQIVTCNQAANGCVVNASAPRPLVFLSSDAQAEENPKATRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ34</accession>
    <name>A0A4Q9PZ34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ34"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="588" mass="66905" checksum="CBDD980F15520235" modified="2019-07-31" version="1">MTTATRRSLTDVPDILYNVFSHFDVHAVWYNDNRSAALYDSRRSLAMAARTCRAFTDPALKMLWSSLPDDQPLSDLLCTLGIATRERDLDYQSRHDEDKPQRYRLPPTDDVGGYPDFDATDAYERRWKRARGYDVNYSISTPGDPRTHAHWDRFVEYASRVRAVALFIFDGPKWSRLWDELQSAAGGITILPMLYTVTFCEIGPRRALTPGIFALLPPSVGKLRLPLPPSRLDSSVVRKYFPHIRHMDVQPECGVEDLRMLAGFPTLRWLSISLSFGIPSPNLALPALPVLGTLAMEGSWTDLTTLLNSAHLPSLHTLSVAGWEGEDNASKLAMDVKQCFHAISRYKSITNLSIYTTYTPQHQYGCVEDDIPEVHGTFDGDLLDTMRPLLSLRSLRYLATRLPDYLVGTESDLSLMADAWPDLVELHLIIWVYQGWSRAYIPRPERPYGGRLEGIAHFAGKCPRLRVLHLPAMEIAEESLGAVEFPSETHDLQTLVIEKVLFPYGRADLAGQISELVRRVFPRVASAFEQDQIRFGKEEFYFSEDDDPDPGEEEGKEEEQETWGFVRGASGRFDDCTKHMWLRWRVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ73</accession>
    <name>A0A4Q9PZ73_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_790995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ73"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <location>
            <begin position="107"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="435" mass="47152" checksum="5D780306E4064AEF" modified="2019-07-31" version="1" fragment="single">MSTYNSFYQGTRTFWKVAAAPGSGSQAPEPREYEATGELLNSTFLPPAEQGTVNPVHPSPPLFAATDIELSVKWGISDYDTIRDRDVGRRVTRKVAKAIREGATLPNAESLSYRGHRGMRGSTTAASNPSTTPNGMVSSTGSEIAVTADTRPEEDSENEETTEVSILLNSEDDQLAAESDGIGGQDAVEGDLGADESASVSSNQWKVVQARCSPEPQTTGILPVVTRYFPSWFDLCDFEDQLGPIPTEWSITTTGSPILPEVIGGETSLLDEFWQEVDSGDEDGELQRAIAESIRTAEPNVVRRTKIESEHLEVMATLVEVVSEEEKEPERPTGPGGRYTSKQKGKQVPRTSQQREFLKMFVSGQTRKSATPAPERPDRKEKESKTGPTRFKRESSQVPDGGWFHKSTENGGRGPPSPPSSSSSDSSDSSSTSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZR2</accession>
    <name>A0A4Q9PZR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial glyco protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923539</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZR2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZR2"/>
    <dbReference type="OMA" id="CEYMMSK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="267" mass="29578" checksum="9049E63B2FB4369F" modified="2019-07-31" version="1">MSALRALRQLTASSSRSLAARSATRAVARATVAARVAPVASRAFSVSAKRLGEGASDVALTQRLAEELKYETEAAPPTEPEFLKAFKAQGTWSIEDTPGLDEVTLTRKFGNEDIRLIFSIADIQTEQEAEFEEGQEGVEEGAEDADAPLHAYPIRCSFSFTKASTPGALTIDAMCQEGTFVIDNISYYSDAKVGTELTAEADWKRRGYYLGPQFDTLDISLQDEFDKFLQERGINQTLAYFVPEYAEHKEQKEYVSWLKNVKDFVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZW4</accession>
    <name>A0A4Q9PZW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_815735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the exosome component 10/RRP6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZW4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZW4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071040">
        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000059">
        <property type="entry name" value="Exosome complex exonuclease Rrp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.80:FF:000001">
        <property type="entry name" value="Putative exosome component 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012588">
        <property type="entry name" value="Exosome-assoc_fac_Rrp6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08066">
        <property type="entry name" value="PMC2NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="745"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="850"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="861" mass="94908" checksum="80FD8A7F8846A672" modified="2019-07-31" version="1">MSLSSDLSSSSFNDYNGRLQGSALKATHAAVSLPADIPFHRSIHSEFAKRLDQCSARVLSLTNKLLTLSTTANAANSSRGKGKARLETQDDVVDNFHSMVVDAMDQLLENADIGIDQFLGNLKAPAIAVNPTPATAQKVWVQGRLDPALQHASYLAKPQLSFKRKVNNNRHTAWTPTLKHKYNAQVPLGYNFGEEGEEPSTSLHPYRYEIRHIAYPSRMFTSAPPISPRSFEETPFSWVSTPEDFATMLDKLRPASEIAIDLEYHNYRTFSGFVCLMQISTRDEDFVVDTLALREELEELNEVFTDPNIVKVLHGAESDIVWLQQDFNLYIVNLFDTYHASKVLDFPRHGLASLLEMYCDFTADKRYQLADWRIRPLPKEMLEYARSDTHFLLFIYDNLRNALLDRAQSRAQSRAQSPSSPTSTPPPDPSIPPAHVLVREVLSRSEETALRVYEKEIYDAEFGLGPGGWDTMARKWNKTLLIGSMAETNTGAAVNVQRAVYRAVHAWRDKIAREEDESTRYVLPNHYIFSLAERTPADMAALLSVFHPVPPVIRRRAKELLDAIRDAVKGALGSGSTTERGAEVTASVEGEEIMSVDDPLTTVVTATSMASTVSPASLWVNGELIENTYRSTLCSRLDEASSITASSSTLFGPSLLRNAATTLPITSRSSLLGGKSDAVSLSQRIAPHKTRFLEAASRIHSALVIAPTVPKIVSVNSETSVTPIVSTPDDPDVLKNDGVEELPFVPASQRKRDAEPVDDTIVVVGQPKRKKRKGVTEKATNASDSGATQDTSPMEEVEAFDYASAPNILDDGSDHERANASGAKKKQKRAKGSNAAYYGNFGAAPKAHSQPKSGNQSRTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0V6</accession>
    <name>A0A4Q9Q0V6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_350133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0V6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14163" checksum="A4BE320C3D293770" modified="2019-07-31" version="1">MFRCRLLVDNSLCTAIFSSHFIVRSRELGMTGGASTESTLTFGFLVAFLGIFALGITGGIAWPHLRRTLAIHFSMFRIPQDLVSIAANEQSTPELWDVCVREVVKNARASGCAWEHLRASTPLPLLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1S7</accession>
    <name>A0A4Q9Q1S7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cation efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_250577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1S7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1S7"/>
    <dbReference type="OMA" id="FWVVMRV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006882">
        <property type="term" value="P:intracellular zinc ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904257">
        <property type="term" value="P:zinc ion import into Golgi lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045316">
        <property type="entry name" value="Msc2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45755:SF4">
        <property type="entry name" value="ZINC TRANSPORTER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="685"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="339"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="673"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="465"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="465"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="502"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU60901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="846" mass="92453" checksum="189798BA74248B32" modified="2019-07-31" version="1">MDSVDSRTRGKISLQSSGSASSSSVLPRRLLADVLLVIALNAGKDYLLTEVGVFWVLVRVLACGGLSVIIWFATAGQLHTKRVTEWSVMGMSSLLLFLRHAGLFTALYRLPSTRAILFTHFSPFWLKSLTTFASLKQASVVVLALSLSFLWDARFSPANFGDHLPGYGALIVEAVSSAALEHTESILSPSLGQPVATAISLLGACVFSLPLYMLRHILLGDSGHRIPSLASLAVLPCMAYIVLHFEPKASVSSNIAVTSPRYLTLSYIMTFSAAIIFGYLGFGHVPKLIDFVVPALLFYGVYPKPAQHSRGAGSFYASSSRLMRAYLKDILSNPESRKIFYFLMLNMCYMLVQMLYGIWTNSLGLISDAIHMAFDCMAIAVGLIASVMARWPPNERFTYGYGRIETLSGFANGIFLILISVFIVFEAIQRLLDPPEMNTSQLLLVSSLGLGVNLFGMFAMGGHHHGGHSHSHSHGHSHAPSVPPTPISSAHDQSHSHSHGHMHTEDHSHDHSHTEDYSHDHSHDHHHSHSHSVIADSESDIQTHPTPLSSPRSEHGHSHSASHIPSEPHSHSHTQPAHNHSHSHSHSHIEDTHAPLTSSESRSGVHSRHQSLEIKIDTPSHLHLHPAHARLQAENVISPITPNYKFGHDDHFETHHSSGHAPNLHDHSHVHDHAHEGHSDNMRGVFLHVMADTLGSVGVIVSTLLIQLYGWTGFDPIASLFIAILIAASVIPLVIDTGKVLALDLGTKEKSIREALTELKPIEGLASYSAPRFWPKDSSSTIGTIHIQLAHSASSLDPGGPHSSTRATVTRVDRVVERVDKLLRSRVPGLEELTIQVEDSSSHYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3D1</accession>
    <name>A0A4Q9Q3D1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_812113</name>
        <name evidence="4" type="ORF">BD311DRAFT_742248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143497">
        <property type="protein sequence ID" value="TBU23715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3D1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3D1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU23715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="346" mass="38210" checksum="542AD54412C38372" modified="2019-07-31" version="1">MSSSKLVLVTGASGYIAAHVVQKLLESGYRVRGTARGKKVDFLREFWKANPHFEAVQIEDIATSDFTEALKDVDAVLHMASPLAGTQTVETTIKASIISAIEGTLNVLRQATAQGVTKFVLTSSWASLVDPDAKQGYEGLTLSEKEWGKTSREDLLQPGRSDMYVYSGTKILAEQAAWEFTKKHPEVDLATICPPFVYGPPILPLSNSFLGTPGLLYQLIVGEAGRPLPYQTSPFWVDVRDVALAHVRALELPPLPQGADRQEKRFLIASPVALTFDSAVKHLYDTRPELRKRLPSLEEVSQFPGPLSKNDTTRAKEVLGITEYVDWRKTLEETIDALVEAEKTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3Y1</accession>
    <name>A0A4Q9Q3Y1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_151742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3Y1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18235" checksum="F164A10DB0A284BB" modified="2019-07-31" version="1">MATNALQTRASFSQQGPPSPTEVGRPSVCTAMAGTRIDRLPRERQGPWVTFQPTCYVARGYCPRPRGVYPQHIQVLGQRSLIGHTWDFRQRSLLAASAAAMRIASGRRGNSFARRVADGRACEDGSTIAGQGSLSRLAAIGTSSRGLVLLRGCIPLTPSLGSPCCHPAVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3Y3</accession>
    <name>A0A4Q9Q3Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1036638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3Y3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51192" checksum="CF5B701B4EC593CB" modified="2019-07-31" version="1">MSSTAIPSACWTVLPAEMKLSIVDQLDLHDVHAFSKVSHECYQLSVPALFRCVNIRSAEALHQYAISVPKSYNRHIRQLTICTKRAKAQQKASPSSPPIRVTDALTEVLPYCTQVEQLTLSLAASLAKAVIPCFEELSALDSLCIDHCGDEARFPLSERLIVSIAASVPNLRHLSLDRVTRSALHAPDLVGARPFVPVVRGDDDIPDHPVLGHELRLPSLLRLPVLKSLRIRDTHLGDPHWATTPVACSLEILDLGSCYHESHDYNRICTERIMGTIGHTVDECALNTALTPQTFAHAKPDTPRPLKKLRKVHLTPLFPVENVVDTLATLSDSPVESLSVECHKDDVVDMCSALEDFLNLRVQRGQTGFYQHLSEITVSTVNDLADALDIGVQSTKSRVAEELSGESADAVRRLREYCRDLRLGATSKEAESESLSAEKAAANATRESASAPAAVPAGQAETTHGQTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4A6</accession>
    <name>A0A4Q9Q4A6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_990294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4A6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4A6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="237"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="327" mass="34705" checksum="DDAC207FE70BCB0B" modified="2019-07-31" version="1">MPSDAPATRDAGSPPQSRSPSPTGADDSLTLRALVNSKDAGVVIGKTGATVARLLEQTGVKAGVSKVIPGVHERVLTVTGSVEGVAKAYSLIVSQLVSANPSSPVTSNSSSPTTAIRLLISHNLMGSVIGRNGLKIKAIQDSSGARMVASKDMLPQSTERIVEVQGSSESIGRAIEEIGRCLLEDWERGVGTVLFHPGTGDERSGRRTHPTGRRANGDGRGRTSPSPNSPSSPQGTNLRTQNISIPSDMVGCIIGRNGTKITEIRRLSGSKISIAKEPHDETGERMFTIVGTPEANEKALFLLYNQLESEKERRVGRDQQQQEELQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4N3</accession>
    <name>A0A4Q9Q4N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_811190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4N3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4N3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="632"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="771" mass="82894" checksum="40E207B33CC38B39" modified="2019-07-31" version="1">MSRLRSPSRPSASESLFVLADLQEFGIPGQQMPLPSAAALASLADAATWSPPASSSRRLSDTSMVLPSMDEETYLDFTPGTTPVTPVRPPPPSLPLPSPPQQRLELPDPRRAGSLGTLSALPARSSEHLPLKSLPIPRPRRMESMDSVSSSRSRHGARSAPSPPPDYGVAPDSRPFSVMSQSTEQDLLAIAELLSPAVDVSTMEMEPIPEGPSEELDSFDDMFADEITASRAIRDSFGTVPSDYSQRSSHRDSRTSNLSVSVYSDSDGGSYMGDEFPDPALLSPPSHRGNRGFQLHRGSLIPPPLDDSRSLSSSTSYSSLRTPSLSRTSSLAYLASPPVSPTSPHAPSDTAGPSSPSVSNPNAKLLGIIEESLHAEEAGGEHYHSRNTSEATETFILEDYLNDEETPQRQEFPSRSAHAYANHDEERQPSRSESRQGAMRSPSGSHHKGEPYSPLRSPAMSRSESRTDSYRTASRSPQPARRPPALHLQISGPAASPASAPPAELAATSPFGAQPFRPQRRSTQALPPQPRLPLAAQLGQASPVVDERRDSAPYAREMQSPFGNLRSPPLSSPYSSGSREPYTPHTPRFASPSNYSPDATSPPPLFVDRPSPSLANGVLHQPARPEIKKAKSSSNLPPVPLSPVLSVESDVSSNDKRSVKSGIGKLFGKNGSSTGSDKSLKEAKKSKDPSARYSSTSSSDSNVTLADPKAEAKRLKKEAAKARTERLAQDLADKAKRRAEEAKTAKANYVKQKSQRPWEESGGLYEGISYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5C6</accession>
    <name>A0A4Q9Q5C6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_986871</name>
        <name evidence="13" type="ORF">BD311DRAFT_660299</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5C6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5C6"/>
    <dbReference type="OMA" id="EMTKMRY"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF44">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="553"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="850"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="124"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU29869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU62613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="877" mass="99022" checksum="02066C7E5F4CE75E" modified="2019-07-31" version="1">MSYHQQIPQHDPYANAYPDYPPAAPQPHNAYNNNPTAHLAQQAMQQDYSFDQHSNWDAKSYNSSYAGSQAHLNPHEMSQVHAPPMPTMPYQGMGNYPPQQRPGMLREQSSGYSVARDKLMKRRSVRHVELQQGNLVLDMQVPSHIVPKGMEKAEEMTKLRYTAATCDPDDFMRNKYTLRPYLMGRRTELFIVMTMYNEDEVLFVRTMNAYFAECKPSFSVLKNIAHLCSRTKSKTWGPDGWKKVVVCVVSDGRSKINKRTLQVLTLMGCYQEGIAKDSIGGKDVTAHIFEYTSNVIVTERGEVSQSACPVQIIFCLKEQNKKKLNSHRWFFNAFGPLIQPNVCVLLDVGTKPTGTSIYELWKCFDKHSGVGGACGEICVDTGKGCSLLLTSPLAASQNFEYKMSNILDKPLESVFGYISVLPGAFSAYRYKALQNGPDGKGPLASYFKGETMHGAGSDAGLFERNMYLAEDRILCFEIVTKKRESWVLKYVKSAKASTDVPTTVPEFISQRRRWLNGSLFASVHATVFWWRIWTSGQGFFRKILLQLEFIYNAIQLVFTWTSLANFYLAFFFLVSSATSDVNTDAFKFLAKGAGPDVFEVFLKLYLGLLFIILVCSLGNRPQGSKWTYTVCIVLFGLCNVITLWCAGYTVYLAVPHTVAGWKDFPHLVETNATFRDIVISLAATYGLYFVASFMHFEPWHMFTSFLQYMFWLPSYVNILMMYAMCNLHDVTWGTKGDNGSAKDLGGAKKVNKDGKEVMEVELPTAREDVDQVWQASRTALSFKPPEEKEHRDAATKQADHDRNSRTNVVLAWVGTNILMILVFTSSAFTKFVNDHVQSTQGAAFNPYLTFLFWALAGLSAIRFFGSFSYLLLRLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6H2</accession>
    <name>A0A4Q9Q6H2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_871465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6H2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6H2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="416"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="56817" checksum="C6237C94AE602B89" modified="2019-07-31" version="1">MNGTQAAKHGRPAPAGPTPPAPATAPPAPPNANSNAPNANAAPAPPKQPNGTAANGAHAPPAQKGKKKTAEPQPVDPSQMYETLKSRIAALEEEEVHEEEEERRFAEEAQKSVWGMTETAIHAKYIELFAELKRLERDHAKEKQKLVKDKDAAKSQLTKANQTKTKMENLARELQKDNKKLREDSKRLATCVEEAQEEITQMKTDMAKRAERAKIQESKYREMPDIVVRVVCKYRAELYFKISRKTKLARLFNAWTERMENNVVSSAGSAAAGKKGASSLVNGTGTIVGSASGAAPSACAMQFIFSHGGRTLEPDQTPEEAGIEDGDVILAVEMMDLTDGPGTEELDEGQPRPVRPKLRKEWVEDPTEARKTLQSIFDGVVRERLKEILRQYKLREQHFECVVRSKELEVLLSRARAAEQKQLADAEKARADKMEEEVKQLRKELDDATEQQTILINKLLSCCHEPDSERTRQFLQSLHGALHKQEAHKQQDGPPEGQNQKVVNGSRKADGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6L0</accession>
    <name>A0A4Q9Q6L0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PrpF protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_918162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6L0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6L0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007400">
        <property type="entry name" value="PrpF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709">
        <property type="entry name" value="ACONITATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43709:SF2">
        <property type="entry name" value="DUF453 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G00360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04303">
        <property type="entry name" value="PrpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="406" mass="42846" checksum="DD3DEA6BB98A50D1" modified="2019-07-31" version="1">MMSTSRSGYARIAHGDMMRARSLTQKVANPLPASFLRGGTSKGIFLKRSDLPESQDDWKPIFQGIMGSPDPHYRRQLNGMGGGVSSLSKICVVGPPSSAQSGVDVEYTFVQVGIEDGELDVSGNCGNLSSMIGVFALDEDLCTPRFNENSGLGTVRSYNTNTAKVIDTTFPLSSSHTADLERPEVEVAGVPGKASRIVLQFVDPGGARTGKLLPTGSPSDNLALEDTAIPASLVDATNPTVFIAAEHLAGAIGLEHRELTADHLTRPDVEAVVERIRQAGAVRMGLDPSAKAQPKIAILNEPTSDKDLTDGVDVIVHAFSMGVLHKAVPMTVGLCLGVAAGVKGTLAHDILARARGRRGVAPEGMVRIRHPGGSVDVGAKFGDDGSVLNAQVVRTGRRLMKGVVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8N3</accession>
    <name>A0A4Q9Q8N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_1018484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8N3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8N3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF26">
        <property type="entry name" value="GUANIDINO ACID HYDROLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020673557" evidence="5">
        <location>
            <begin position="27"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="411" mass="44770" checksum="C2BCBDCBD5F8C1E0" modified="2019-07-31" version="1">MQMPKTALATLLGTAIVLANLPLTHSHRDGHHHEQVQLPLEEFAQPSSSGSQTWLEKYGKQIDQVFSGPLSFSHLPYSRCLEDENAQFDIALLGMPFDTAVTYRPGARFGPYAIRSGSRRQRESRGYTLSWKNNPYELGSRIIDCGDVPVNPFDNALAIDQMEVAYSTLLGRTPASEGSVTSITQHFAKDGKQHPRIVSLGGDHTIVLPILRSLNKVYGPVSVIHFDAHLDTWPSYPGPTSEQSRVTHGTFFYLAREEGLMTNTSIHAGIRCKLSGVADLENDASVGFQLISTDDIDDYGVAEIIKRVRERVGDSPVYLSLDIDVIDPGLAPATGTPEAGGWTTREVKRIIRGLAGLNFVGADIVEVAPAYDNAEITGIAAADIVHDFLSMLLSSKPPAPHSLFAPAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAG4</accession>
    <name>A0A4Q9QAG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycosyl-transferase for dystroglycan-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_837938</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAG4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAG4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015020">
        <property type="term" value="F:glucuronosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042285">
        <property type="term" value="F:xylosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051292">
        <property type="entry name" value="Xyl/GlcA_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270:SF25">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-LIKE PROTEIN LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12270">
        <property type="entry name" value="GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13896">
        <property type="entry name" value="Glyco_transf_49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="605" mass="68079" checksum="16BF67F1BB4FB076" modified="2019-07-31" version="1">MGVNVIIRLLQFCVCLYVLAAVLFTTCVYVLAPVTGFFRSRTHASPTASSSSTSSHYDIRIASLSQDRPEVRLDLRLADPLDNSHWVDNWPSGYASSELLYLSHTGNSIGTHLATGGFGIHEETLLSKAFSEAMHPTRIIPFYFKSSNDVHSDDVTITTLVTSNRFKVLQQLVERYRGPVSVTIHIPLPLHATFSSLKPDHPSRVALSNLHALYVSSPLFSQYVDVHLALSPFTSALSADPVVQRESEGGRQFNVWRNAARLFARTNFVIMLDVDFAVCTDWRGFVRETIREAAESPSPIRPPFRTGRTHESIRAADAAGATATEIVKKLREGTAALVVPAFEYVKQRDGIDQRTFPTDKQGLLKLARANPPVIASFHASWAPGHNSTEYERYYSIPPGEGAIYKVEQYQSAYEPYVITSKHVSWCDERFAGYGGNKAACLFEMYLSGVSYYVLSDHFLIHQSHKYEEEARREERKSNRKLYADFKEESCLRYLYRYYREGTLHTERAANARDECKKIKNITKMVTQVMHVCLASSYGIAHRSGYHRKHRNPVGQWLNAVAASLTMAFGCLGCVFFTNMFMLIGCSVYAMYINVPESASYSILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAY4</accession>
    <name>A0A4Q9QAY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAY4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16397" checksum="25E8B2953731D16B" modified="2019-07-31" version="1">MRSPGIQTPLPSTHLAHNVHSNRHRLYHLNVRLPPCCVPIPRLLSTHALRASSLSRLGDLRSPSTCGSYLVHTCLTPGPAVPHNHVAHARAALALISALPCGLMCIPVVVLRRQCGLRTCGSCTFGHDTKTRMLTRPQARNPRLLFAISTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBM8</accession>
    <name>A0A4Q9QBM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_299597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23361" checksum="281BD26E577E8639" modified="2019-07-31" version="1">MIVSAPWAEGGGVMGEGEGEKNTNRLETTRAADVVLYSGSINMSLRRQDQKLHGSHTYAAELISSVLSPAISIRQEHLSLTTMAASRKSASRSGLVPATEFLSPVRRVSGEHTYVSREEGDIHKDGANLRRSIVDLACLFVPGGSGRQGKKRHRTFLAVSLVEMYPNPWLRLPSPRQQSYLSGLVQTAWAASGPYQIRMRLRRSWFAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC08</accession>
    <name>A0A4Q9QC08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_914972</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC08"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC08"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="552" mass="60013" checksum="421DEF5800F8B457" modified="2019-07-31" version="1">MSSSIELINPKAESVRRAAALQVNTTGAMGLANVVKGNLGPRGTLKMLVDGSGQIKMTKDGKVLLSEMQIQNPTAAMIARTAVAQDDQVGDGTTSVVLLVGELLKQADRYISEGVHPTVIGEGFDIAKKEALEFLDKFKRPVNLDRATLINVAYTSLATKVNSALAKQLAVEVVDAVLTIRPPPPSPDSPHQFREPIDLHMVEIMKMQHRTASETQLVRGLVLDHGARHPDMPKRVENAYILTLNVSLEYEKTEVNSGFFYSSAEQREKLVESERRFTDAKCKKIIELKNLVCDQAVGSNEKKKNFVVINQKGIDPLSLDILAKNGILALRRAKRRNMERLQLICGGTAQNSVDDLTPDVLGWAGLVYEHTLGEDKFTFVEDVKDPKSVTLLIKGPNPHTIQQTQDALRDGLRAVKNALEDEALIPGAGAFEVACAAHLNGPVKKSAKGRAKMGVQAFAEALLIIPKTLAANGGYDVQDVTVALQDEAADGNVVGIDLESGEPFDPTVQGVWDNYRVKRQMLHSCSVIAVNLLSTDEILRAGRSSLKPDGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC14</accession>
    <name>A0A4Q9QC14_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC14"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC14"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="173"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="384"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="446"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="649"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="759"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="785"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="759"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="830"/>
            <end position="839"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="913" mass="97016" checksum="72BB6571D78642B2" modified="2019-07-31" version="1">MTIEDPPWKKKTRPCPFYSQGRCLFADSCNFMHTVRIRRPDSVLGSEDSDQPDFRLRIDSPTPAKTVRFTSPSRSPRTTSLLLALGDVIQLEEEEEGDWEEGESGELESSSGEGSEGRTSGDYSHAGPVAASSSTGNLEPNPPGLHSGAVSDNSLRPTPILGLSEDARRLLHCIPSPPRDASPHLPEASITDGSATLVDGSSSWSGTPSASTAIIDEDVTVTRFRHSMTSQDPLHSNRESISSYLQDSPGGSAIVSDYFPSRRTSEAPDLYSPSRRASTVFDVHSPAPSCSGPAPIAPESLPLPLSPNSPPSDIPDIQPPARPTSTVPELRRLSILSHRSRFTVSSHDSISSGLLSPIDLTGARRISFASIPGALEREESFDSGYAEFSGPEPMRRSPPRSPRRLSTLSILSSPFGSPSARMAQAGAGAGVSGLFSPRFGAFTNSLTRDAHDGESGHSRNDSVDSQQFTREDAEVAIQVQRQSGASFEDIPADPEESSLFSALNASEFLGAEDDLLHAGEASFGSDDSMASLYDQYYTPTTHTRSVPDGEGEGEQEASPTVMFRSYAPHQSPLRDEQGDASPLDFSYLQETSPATVMGSQEPSPQTVVASQEPSPANVTVVPDSPEAAEEQSFATSDFYEELAYLDPEDIQEDISVAADDSQQAGPSTSFARSPSAASSLSEAPRVFSPITRPPSSASSVQVPNFSLPNSARNSIVFAAPSRAASPAASVLDESAAESTSRPASALSQHSGGLRRLSLQSAASMHSSQSSQSASRKVPFGFRTSVSDRSQLARPDSLRLKPPPLLAVENVQEDTQSRATTPLSPVEETPLTGSSTSSNPRKLKPLRLSMILSSSSSSLGSAYPSSSIPSLTTATTATTAFTPSSPTVSSDYSLSHNTLHYTFPSTQYHRILTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCC4</accession>
    <name>A0A4Q9QCC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Plasma-membrane choline transporter-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_864019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCC4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCC4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="477"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="686"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="118"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="789"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU65403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="808" mass="87640" checksum="118D9641F1146831" modified="2019-07-31" version="1">MATSFAAYASQFLNRQQTGASSLSSSQPLFYSFSTDNGSHVGSPHEPDLDDLDDPHLRASNVSRAASRRARDVPEDEEDPYLRLDEEDPGVSRQQAQSIPLLGVSEPDGGKGWLAHASPLRSPSPSPSNSSADSGGPPPDILHPRSPSPHHTRPPQPTSYQPAPPPRTAVTLSLTESLLPRDGRTRPVDVFSLPDPRYVPRNRRKFNDSIWTSVWCAGVGVCVFSSVLILFLTEAPPGPSRGSYTTLLHTVPLLTILTFVSAVVCYIHVFLLRIFVKPVMVATSVFIPATLLISAVWSFIGSFMWDANTVPTWGETWGLRLFSLVPLALAVYTGRQLLNLPRDIHTASSLLTLTTRLLMENPFLLALSPAVLLAMLLLSIPFITLAFRLLLVGYWSTSKSPRSVWHVAEWAHWAIAATIGVWLWSWGVARGLLRVTCAGTIGAWYFADPALPPPPPTSTHTIHAALMRSSQPSLGTVVLSALIVTAIRVMGLLTVALRALPAYLPPYMRIVSVGAGMVVGYLEGATDSLSTYALIYTGLTGDAFFPSARRARALVGALENPSLQSYRRRFKTEPPLTLLTVAPLTLTFPFALITYLFVAHTLGAPNSALSAALLAGGVTALVGMFCIGLVKDTADTLYICYCIDKDAGERRRKEVFAAFEYENRSQVSQPAQQRRPAHAAPILPTHQDRRQPLPSSPPLVQQPLFSHAPPLHRDSTPDPFEVDNSSSDHEENPAGYLLQHDPYSPRSSQAGGRSALGGGSQSRLPLSQRRPSEGTLRGGVPVSALEPPPESDEEDAEDSQLFPGSDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCC8</accession>
    <name>A0A4Q9QCC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_805253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCC8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCC8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="719" mass="77791" checksum="C7B55A1837CDBD69" modified="2019-07-31" version="1">MSADLPPTYTQEPSEADAQLSDDSDLSFVSAHDEQPPAAALNDADADDANADLGGGSAGPQILIIPVADGGVHFQKGYLGADGERAAVEGELQIKSADAGFRWRKVSVALRSVERAHGREIELANTEIVLASSPDPSPQQRSSFPFSIPLPLDTPQCLHTATSSLAYSLSANVWPAAEDADPLRRSLVIHTRRYTSHTHDLHPVPETRVITEPSRVEVQLPRTTFKAGEQIPVYITVPTPSADFVVEQGQRLRNLRAELVRVINVKKNESEEGELDEDDFENGSENGGQPSSLTQKTVPGPSTSRTPPDFIVRRGERGERKVIALSGASCRLHPSRPLRIRLVLHQPTEPPLPDSPRHQPSTEEAYSTSFDAECAYITQSTVLHSVSFRLLVHATFVRMSSHTERVSTVSIPLLILPPSAPLPEVEPSVDAAYIKKHDRPPTRTVRLEDPEVPQYEAGPSAAPGAPPPFEEREAPPPFWSAEAEASTSSRLPTFLESEASTSRLPTFLESEHEIYVPPEEDPSIAPPPPLPVSELVFEGEGSLFGFTAADQFDGYADVLDQRSFTPPPSLEMATHDANVTGLANMDLDEGAAIEALGLALEQQTIALNTHGLSGENNSVGAVDDHFLPPPPPPMDDPSDPPPSIDSAEFRAPGALHDSPPRAQSPQGHGMVPPQTPEDEGESHGHAPPPYRVPDHDHEHEDGGHERVTHPPPYMDLVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCM6</accession>
    <name>A0A4Q9QCM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_289506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCM6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="132" mass="15263" checksum="0F02A14A3E62120F" modified="2019-07-31" version="1">MKFFHRDVQPWEVVDQQAVDTVPIFTEEEQEDLNVVKVYDATMSGVYDFELKKASNLKDAVVFARQTLMEDAAEKGYNVFLTEGWKVTHLRRGKQERAEVRYWGRPACVQGTVPRAQTPPFLTMLDDRPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDL5</accession>
    <name>A0A4Q9QDL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CoaE-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_8632</name>
        <name evidence="5" type="ORF">BD311DRAFT_792920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDL5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDL5"/>
    <dbReference type="OMA" id="CQMDIEQ"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000485">
        <property type="entry name" value="Dephospho-CoA kinase CAB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00152">
        <property type="entry name" value="dephospho-CoA kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU35591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="237" mass="26768" checksum="0FBEFC0E057FA1D0" modified="2019-07-31" version="1">MLVVGLTGGIATGKSTVSALLRARNVPIVDADVLARKVVEPGTPALSAIVRVFGPDVLLPDGTLDRPKLGRIVFADEEKRRKLNAIVHPAVRREMFWSVLRHWWRGERLCVLDVPLLIEGGLWKWVGKVLVVYCSTEIQLQRLMKRDNSSREDASARLNAQLPIAEKVKYADIVIDNSGTPQELERQIDGVVRRLMEEAGWTWRLSWLFPPWGIASAALTLAWRALRRSQKGKLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDY5</accession>
    <name>A0A4Q9QDY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_32252</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDY5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17679" checksum="40ACAA1A46B35F25" modified="2019-07-31" version="1">MHCLTPRLFRWHASRSRSCCTWSLTSATQMRGSARSREETRLRRLNSQVCQEDVHWERKGDASGECKRGLAPRYFWGDMGGIRRGKNREDEVVMAAVARTACGDVRSMKQDSPVSEQEQVRREALESRRRARDAIGCRGRDGNPLDAPRGEQRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QED1</accession>
    <name>A0A4Q9QED1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 11">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_865709</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 11">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 11"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QED1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QED1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF16">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0520">NAD</keyword>
    <keyword evidence="5 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="12">
        <location>
            <begin position="3"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="13">
        <location>
            <begin position="140"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="8"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="110"/>
            <end position="112"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU66202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="326" mass="33308" checksum="1181C5E65123DF2B" modified="2019-07-31" version="1">MVKAVVLGAAGGIGQPLSLLLKANPNVTELSLYDIVNTPGVAADLSHIATPAKVVGYLPPDDGLKKALTGADIVVIPAGVPRKPGINAGIVRDLATGIATTAPKAFVLVISNPVNSTVPIVAEVFKQHGVFNPKKIFGVTTLDVVRASTFVAEILGDLGKAPSVVVPVVGGHSGVTIVPLLSQSSHPLPSGFAQDALEQLTNRIQFGGDEVVKAKDGAGSATLSMAYAGVEFANKIIRAVKGEKGLVAPTFVNLAADAAGGEALKKEIGSDLEYFSAPVELGAEGVVAIKSLGKISEYETKLIKAAVPELQTNIEKGVSFIGASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QF24</accession>
    <name>A0A4Q9QF24_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_984973</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
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        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="210" mass="22976" checksum="9768A6D736A686B1" modified="2019-07-31" version="1">MPSVDIELDDFSHSRAQLEDTTTLEPLPNPNSHKDDGVVSSWAWTSAIILLLAAAPLILYPKLLLFLSETGLERRVSLTPLESFLAWNTGIVLIVLAVALVYNIHPGHEILNPKRSGPPDHPLLEPMTSACLLISFLSYNTSSVSSLGFLVCLGSGTIGLWGLWAILFAGSSYISRKTGADKRTSRFIFGNKAAASSKKKEWKKEQARRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QF87</accession>
    <name>A0A4Q9QF87_9APHY</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_30554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU65871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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        <location>
            <begin position="99"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
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            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="337"/>
        </location>
    </feature>
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        <location>
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            <end position="467"/>
        </location>
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        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
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        <location>
            <begin position="518"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="546" mass="57573" checksum="B50709CDF5CAD700" modified="2019-07-31" version="1">MPGVLAHLSSLTAGPGTLFSHPAPHVLFVDSLYHRVDPVSARGWGSPLAKPSAERGRQVASGRMDVFLPYSAPRPEFPPYVEDDEYPQDCGLQNIEDMLPEEDEVSSSSDSELEEQPPGRWDMPDPQSAEGPRPSHPRPERGGAPTSTSSWMEEAAGREQRMLADRMLADRFYSAPARRRTPSKPSSFAAPKPRPPPPKPPAAAAAADPRTLFRPPPPWSSLPAQPPPRRQAAAPAGRMPTGVFASPSAAHTPRPQGAPAAQTRKRMVTLSSVQHMLDMVQKRSSGPDKAGRARAAPPSVPLGRANPFARSAQATAAGAPRLPLPKAAAPSALAPALDGQRPAGRARSPEPEGHPRPRASPRPRPPANARTDHARPGPSSKSVGKRPAPPPSPAPSRASCGTSRPDPSPSRPAKRLKPITTLTVPDWPGARMKPLSEHNRKLQPPTPSAGTAPKAQRQTTLSATTGARGSGGERTLDDVAGAKAQAQRRVPAPRPAPRRLEVAALKLERGQSIAAKPKGGGTEKGGRKPSGGGTGKAFDWKGWSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFJ0</accession>
    <name>A0A4Q9QFJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Pre-mRNA splicing factor PRP21 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_912687</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFJ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFJ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="10">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="10">
        <location>
            <begin position="156"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="9">
        <location>
            <begin position="697"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="341"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU66066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="787" mass="86953" checksum="26BC144E91715404" modified="2019-07-31" version="1">MSVATQAMPRPPALDGDVNGVAGKGADGANEVHKEPKFASGLILPPPEIKSVIDRTAAFVARSANPPQFEEKIRENQRQDPKFAFLNPADPYHAYYRHRMDKVARGEVDEVATQKEGEKAEEKPAEPAAPVDMGEEPPVPEFILNIPNVRAIDFDIIKLTALFTARRGRPFLAALSAREGRNYQFDFLRPTHSLFGYFNRLVEQYSKVLLPSKEMLAQLKERTQDGARWKDLETARKRARWEQMKREQDKKREDDREAERIAFAEIDWHDYAIVQTIEFTAADATAELPPPMSVQEVENMTLAQKRMAAMVMETTAEDVEAHRARQAAADAEAAAAANGAGDEDDQVMEESDDEDDEAKERKRRDEEERQREIERARAIQASSLDVGGPMKIRTDYVPKLNKKGGEKLTTCTICGQQIAVDELQEHMRIELLDPKWKSQRDALEARKAQASELQRGANVVSSLKNLARTRVDIFGAEADEEKRKKEEEEERLRRREREKDVWDGHTASKANTLDRYQTNSNIDEQIAAIHRAKGLGPQEANAIGPGIGPAAIPAPLNSLPPAPASLPAPPTGAGVPAQNSAYSAATVSSGPQPASLFPQPAPVMLPPLHYQGMDAAQPFGYQPPPPGAPMMHPARAAALQTPLPTGTPPQVGMVRSADEMEDGADGAPPAKRQRVAKLPGGALYPEQDWINMHPHPISLRVQLPNEPSRPEWKFDGSVVTLQELPLSLLVSTLRDRIVQATGSTVGVSKIRVSYGGKMLTNTQTIAVYNLEDEDLVVATVRDEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6P8</accession>
    <name>A0A4V2K6P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_184724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145229">
        <property type="protein sequence ID" value="TBU52983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6P8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="302" mass="32590" checksum="085789B65422A193" modified="2019-07-31" version="1">MAPQIFTSLTARDATDDDSSVNPTIIAGIVLAAVIAAGAAIWLAIRWYRKRATTKRNARRSSAFANFKGFDNASEKSPLPSAGSDLLVKGTFSRDQMNSNIIMPERAVLRPGATREEILEHYTSQGNLPRPFAPFQPQPQSPKSSEFTFDDPPSPGKLPSGRPASNASWIPPLTPLAGGRNSHRMSAMSAVSSVFSTSSGTTQKKVRQIFDPVLPDELVISLGETLTLVQSFDDGWCIAGRDSIFKPGEVELGAVPGWCFVKPVKGLRAERPMRVSSLGVTVDLDAAPTMGPRDNVMSWSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6V8</accession>
    <name>A0A4V2K6V8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ATP-NAD kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_829411</name>
        <name evidence="7" type="ORF">BD311DRAFT_659346</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143407">
        <property type="protein sequence ID" value="TBU30224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU53763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6V8"/>
    <dbReference type="STRING" id="114155.A0A4V2K6V8"/>
    <dbReference type="OMA" id="RYWTADM"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000004">
        <property type="entry name" value="NAD kinase 2, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="483"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="487"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="519"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="596"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="633"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="681"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="731"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU30224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="740" mass="82700" checksum="98B8E02834B2732B" modified="2019-07-31" version="1">MSWLNSTHPNHDHEPRSKEDRHASYADGTVSDSYSETTSPYADEDEREYAQSLTKQLADTAVTVREWSKKLGRTRVRSHIQSVLIVTKARDNRLIKLTRELALYLMQKKRGTDRGMIVYVDAQLKTSRRFDAAGLAREHPELFVPFPKRRNSSNSSLLNGFSNGSSEGPSQPEGQLRYWTAEMCSKSPHLFDFVVTLGGDGTVLFTSWLFQRIVPPVLPFALGSLGFLTNFDFANHQKVMDSAIDDGVRVNLRMRFTCTVYRAISPDKNSKAHRAIKKGDTGEIFMRNVEQDGWEALESGNTSTGRPHGKDKEIMCFSTKPVECFEVLNDLVVDRGPSPYVSLLELFGDEHHLTTVQADGLCVATPTGSTAYSLSAGGSLVHPEIPAILITPLCPHTLSFRPMLLPDTMELRICVPFNSRSTAWASFDGRGRVELKQGDHIKVTASKYPFPTVCAESQSRDWFHSISRTLKWNERERQKSFVVVEEEPGKSRKSSREGKVRDATPTAKRHEEAAKKPEEENEDELDEEDEVSEEEEEKYDIDDLSSTESPSSVSVVSMQLSPEEAKIGQEKLHDDDNVQAEAEDAVRRLAKGDPYLSSTLTSAPSSGLKSGIDTPDRFAGGQQHPHPPRVSPRHVQFLTSSASSSSSSVATFADEYRRGDRGERDDIHSPRSAHHSTRVRIPRDRDLDAENLRTPTPAEQGHRPSFTRSRSRSREPPRRAFAVWGHDESDSAASDSDADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6Y9</accession>
    <name>A0A4V2K6Y9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU54008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6Y9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="204" mass="21359" checksum="43B88C8AE1B9CD77" modified="2019-07-31" version="1">MGLGLIQDGETVQPNSNPAPEFHQRLEAALARTRDQREQNAGIAGQSNRVASRPGSRESPTTLASRTSPSYPPGYGLRTTRSPAPNPPNQQSAATVRVTNVAAQPERHRSVHFGQDNAHRAPTRSSPLAAYPPYVALGVSAPPTHVHSNMGSISGHRNRPSAPQVHPAASAAPYVGATSTIGGYQLPLLGAPSQVAASPDHTNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7Z5</accession>
    <name>A0A4V2K7Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_959139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7Z5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="78" mass="9105" checksum="56256D67B78BED4F" modified="2019-07-31" version="1">MYTEYTTLAAAQHQENVTDLYRYLGYLAKYLKYPKYLKYPKSNGLGQVGWVDLAKYQVLGQVLQVPIQVHAQVHCEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K845</accession>
    <name>A0A4V2K845_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_926843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K845"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="119" mass="13656" checksum="D5EEF3A8229BC544" modified="2019-07-31" version="1">MEVVVLAHDADQIAVELGFDWVVPSHYTLRVDVVSKTPQGTQHRRRPSRPRWKSFRCRRLTLEGGCRVTFWYAGFGGQRGWTGGRLRRRGGWSALRVKWRIGRRGSCMGLMCLMGPRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M840</accession>
    <name>A0A4Q9M840_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_926985</name>
        <name evidence="12" type="ORF">BD311DRAFT_733105</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143547">
        <property type="protein sequence ID" value="TBU22318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M840"/>
    <dbReference type="STRING" id="114155.A0A4Q9M840"/>
    <dbReference type="OMA" id="KDWYKGG"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="112"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="214"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU22318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU58458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="318" mass="34507" checksum="3595A8CEF00463C8" modified="2019-07-31" version="1">MSRAAEKKPVGFATQLTAGGIAGAMEALCCQPLDTIKVRMQLSKSGRAPGTKPRGFIATGAMIVRRETPLALYKGLGAVLSGIVPKMAIRFASFEKYKAWLADRETGKTSVGNIFLAGLGAGVTEAVLVVTPMEVVKIRLQAQQHSLADPLEAPRYRNAGHAVYAIVREEGFSALYRGVTLTALRQATNQGANFTAYQELKKFAHNLQPELTDLPSYQHMVIGLISGAMGPFSNAPIDTIKTRLQKSEAVPGQSAFQRIAAIAGDMWRQEGMRSFYKGITPRVLRVAPGQAIVFAVYERVRKVMETLQGSSEDRIHSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MAH2</accession>
    <name>A0A4Q9MAH2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="19">CPR</shortName>
            <shortName evidence="19">P450R</shortName>
            <ecNumber evidence="19">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD310DRAFT_95238</name>
        <name evidence="22" type="ORF">BD311DRAFT_41404</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 464.89</strain>
            <strain evidence="22">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="19">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="19">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Endoplasmic reticulum membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Mitochondrion outer membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Cell membrane</location>
            <topology evidence="19">Single-pass membrane protein</topology>
            <orientation evidence="19">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="19">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="19"/>
    <dbReference type="EMBL" id="ML143488">
        <property type="protein sequence ID" value="TBU24069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MAH2"/>
    <dbReference type="STRING" id="114155.A0A4Q9MAH2"/>
    <dbReference type="OMA" id="QKRYQRD"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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    <sequence length="727" mass="80507" checksum="82973553C2CCA829" modified="2019-07-31" version="1">MASSDVIVLALGVILAAVYLFRDQLFASSKPKTVPTSTSKANAGGGNPRDFIAKLKEGKKRIVIFYGSQTGTAEEYAIRIAKEAKQKFGLASLVCDPEEYDFENLDQVPEDCCVFFVMATYGEGEPTDNAVTLCQNLSDDSFEFSNGEHKLEGLKYVVFGLGNKTYEHYNLIARNVDADLTKMGAIRIGERGEGDDDKSMEEDYLEWKDGMWEEFSRVMGVEEGQGGDTPDFAVTEVADHPPEKVYLGELSARALTRSKGIHDAKNPYPAPITVARELFAEGADRNCIHVELNTENSGITYQHGDHVGVWPSNSEVEVDRLLCALGLHDKKDTVIQIESLDPALAKVPFPVPTTYVTVLRHYIDISAVAGRQILGVLSKFAPTPDAEAFLKNLNSNKDEYNNIVTTGCLKLGEILQVAAGNDISVAPTPENTSSWKIPFDIIVSSIPRLQPRYYSISSSPKLYPHSIHVTCVVLQYESVKNERVPARWVFGTGSNFLLNLKYAANGEQAPLVDTKEEPARVLTPKYAIEGPRGAYKQETVFKVPIHVRRSTFRLPTNPKSPVIMIGPGTGVAPFRGFVQERVAMARRTIEKNGPEGLADWGSIRLYFGSRTSTQDFLYKDEWPEYAKELHGKFTLRAAFSREVYKPDGSKIYVQDLLWEDRETVADAILNGKGYVYICGDARSMSKAVEETLSRILGEAKGGSAEVEGVAELKLLKERSRFLTDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MIX0</accession>
    <name>A0A4Q9MIX0_9APHY</name>
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        <name evidence="4" type="ORF">BD310DRAFT_927848</name>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597580" evidence="2">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU26628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="16756" checksum="92A02D1AD744A77F" modified="2019-07-31" version="1">MLTMYAKAIRLILLPILVVTALPTGRDDVDDRSLHVEQVASNSLGTASMSSASPSDITAIESAALASFESVETIVGSSQTQFTAFFTLVSEVPYLEVSSIGGPAITLAPTGPLGGATTTFAGHAVTALPSHQNIAHTLAISRRLISGLVGAWLGAVVGGVVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MNT2</accession>
    <name>A0A4Q9MNT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase family 18 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_978147</name>
        <name evidence="3" type="ORF">BD311DRAFT_806174</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143413">
        <property type="protein sequence ID" value="TBU29380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MNT2"/>
    <dbReference type="STRING" id="114155.A0A4Q9MNT2"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597587" evidence="1">
        <location>
            <begin position="23"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="2">
        <location>
            <begin position="42"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU29380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="432" mass="47132" checksum="1ACD5953189998F1" modified="2019-07-31" version="1">MWLQLSSWAALAALFSPLPAKATSLARDAPSDSTNSPSAAGTFAGTWYTTWHNGRVPIDNIDWKKYTSVSYAFVTTDPDHMVSLTADDINGTIFKDLVSTAHNQNTKVMMTVGGWTGSKWFSLLLAENYTRSNFINAVGAMANNYAVQGVEFDWEFPNKQGVGCNTIDKDDAANFLLMLQEFRQNPATSSYILSAAVSDKPFLNATGQPMEDMSEFAKVLDYVTIMNYDVWGSVDGILGPNAPLNDSCAPSEYQHGSAESAVDTWTKAGFPADKLVLGVPAYGHSAAVLPNNAYNNSELSIYPLIYNNASQVPGDSWDGKSGTDLCGVPWDYSGVWYWTNLADESLTSSFINANGTPRDGIDYLWDDCSQTPRAYNRSSQVMLSYDDVRSFGQKGTFIQEKGLRGYAIWEAAGATDVLIDAINSNMTGSKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MS86</accession>
    <name>A0A4Q9MS86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_925838</name>
        <name evidence="2" type="ORF">BD311DRAFT_755505</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143409">
        <property type="protein sequence ID" value="TBU29948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MS86"/>
    <dbReference type="STRING" id="114155.A0A4Q9MS86"/>
    <dbReference type="OrthoDB" id="3367070at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="498"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="612" mass="65402" checksum="F6AA4ED5402570D5" modified="2019-07-31" version="1">MGFFSARRADDLHSAAQDDPSVVRVIRSRFYGKAKGKEREVASAPVTPYTSPSLAVSTVSFSSKAADKRAVVGSIRGPRASTSTTRNWAGSSATSPRRNGNASDMPVSRASTDFMTVTLAQRLNELATANSEGLLSDDEYRLLRQSLFERFASGSAVPTEAPLVPLSNLSLTTVESRTSLTNGRRTSSHLHGQSSGSVRSPSTSSKRSFTSTVTGLLRRATSRRIVSLPPEPHGSDTMSVYSMASSPPERLTLPRNLSKQTSEMSLRTETPSARISQTYSRRTVIGGHTFSATDPGPSRARTRSGSRAAPPSSFPGSPLKGVESTYTHISANDIPDDDQVESVQDIRHQIELVEAEGRRLLDAFNGLELSTLTRQRQFKPPIIPPLPSHGPLGDGSWPSGSLRPGKDMDALSFKSSGSARTARSLRRTPSQGTKMRTVTSASALSTSGAALDRKTSMSSVSSRGRTAGPPLPTVAGHLGFASSSSVNLVRSTGHLPLETVEEAEGGGRHRPKLSTSRSGSMRRDEWADSGIGSPISPSSRSEVGSTGSGSKRGHGAAAAAAAIDDDELMSMETELADIRRRRAQVTGRYEARLEYLRARLKGAELREKILRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MSW4</accession>
    <name>A0A4Q9MSW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ricin B-like lectin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_855708</name>
        <name evidence="2" type="ORF">BD311DRAFT_796442</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143411">
        <property type="protein sequence ID" value="TBU29662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MSW4"/>
    <dbReference type="OMA" id="VIWIARV"/>
    <dbReference type="OrthoDB" id="3249735at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23416">
        <property type="entry name" value="beta-trefoil_Ricin_MOA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="16853" checksum="58EE8541ED44C278" modified="2019-07-31" version="1">MAALTIETGVYFIQNAGTGTVLDLTNGSSANSTKVQGFTKRELNDVWVSAQLWIIAQVPGTDEYTIQNANSRTYLDLTGSNIQNGTPLIGYQPTGNPNQRWIIKRNSTNTAYVIGNGATGTFVDLLNGGSANGTTVNGWAGQGPATTNPHQLWHIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MZ16</accession>
    <name>A0A4Q9MZ16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_915553</name>
        <name evidence="11" type="ORF">BD311DRAFT_751177</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MZ16"/>
    <dbReference type="STRING" id="114155.A0A4Q9MZ16"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU32032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU64202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="458" mass="48796" checksum="261970EF89ABFA0B" modified="2019-07-31" version="1">MAPAPTLDVHPVNGPPAGEPSAGQKSQKQMTKAERRELQEKQRAAKAAKAAANAPNGKLGGKAAKELSALAGAPSKKTGRPSDAASKPPPPGLVKAAQAKAGQASLADQSARNQARGLLIFSHFGLPKPVSAAKGDIHPAIARLALQFSTFKITGANARCIATLTAFKTVIQDYVTPQNNTLSRHLMTYLSPQISHLVAARPMSITMGNAIRQLKLDISGSDIDLPEQDAKDVLFRKIDTYIRERIIIADQVIQETAGNKIKDGDIVLTYARSSVVEKVLLEAHASGREFSVIVVDSRPMLEGKRLLAVLSEAGIQCTYLLLPALGSVISEVSVVLVGAHSIHTNGAVYSRAGTALVAMMAKRHSVPVVVCCETYKFSENIQLDSFTKNELAPLGDLFSSFPNNKPREYLTLENQPHLEILNPLYDLTPPSCITAVVTEVGVIPPNAISSIPVALGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9U3</accession>
    <name>A0A4Q9N9U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_927120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9U3"/>
    <dbReference type="STRING" id="114155.A0A4Q9N9U3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="7">
        <location>
            <begin position="827"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="742"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="746"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="970" mass="108097" checksum="E67A2E87E312861A" modified="2019-07-31" version="1">MVQSYLRHGPTEAFGLVCSASSNSHYDGKLAYVPALEDVLVWDVKKGQQLAMWHETGHRAEVTCILRSPQRDLFAVGYADGSIRLWSASAQSVLATFNGHKKAVTALTFDETGTRLASGSQDTDLILWDVVGEAGLYRLRGHRDQITAIRFVRPTAESAPSTSTGIAPGYLLTGSKDTFLKLWDLSTQHCIQTIVAHRSEVWSLDLDPEQELVFTGSGEGEVKAWKIDHEALAEGLRETESGEVTRFIHPVTTLPLASAHRVSQITFHPHKPYLAVQSHDKSVEVFRIRTEEEIRKKQARRRKRAKEKEQEKKEKGKKKDDDADMQRDEETEELGVELADLFQPYLIVRASGKVRSFDFGGEENGGKDNTQLFVALSNNALEVYNIPPPTKSKDATPEATRVYSVDLPGHRTDVRTLCLSSDDALLASASNGSLKIWNMKTTACIRTMDCGYAICSTFLPGDRQVAVGTKSGEILIYDIASSSLVDTVQAHSATVWSIHVRPDGTGLVSGSADKDVKFWDFERKPANSDNPRSNSSLLTLVHIRTLKMTDDVLSVRYSPNGKLLAVALLDSTVKVFYQDTLKFFLSLYGHKLPVLSMDISGDSKLIVTCSADKNVKIWGLDFGDCHKSIFAHDESVMQVAFERNDTREGETKPSHHFWTVGKDKLLKYWDGDKFENIQKLEGHHGEVWALAVSHHGKFVVTGSHDKSIRVWEKLDEPLFLEEERERELEALYEAGIADTLNRDDAPIGSGAPGADPAAPTAETTAVSKQTAETLMAGERIMEALDLADAERETFRAYEEARRRGGLAGTVAPPPRNPVLAAYDVGPEEWVLRVVEKVPGAALHDALLVLPFGKVVSLMRCLNVWAQREWSLVLTSRIVFFLLKTHHRQIVANRVMRTALIPLRRSLREGLRRQRDALGYNLAALRFVQRQNDARRTAEFFERGDGALSEEQVRERIAEGAKKRKRVSVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NH56</accession>
    <name>A0A4Q9NH56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_867651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NH56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17358" checksum="10B22CB25C29E0A6" modified="2019-07-31" version="1">MNLARPWGPPFHSHIFQASSAGNGKTPDARARIAHNIHASSGANPARPSAIPSWDRAICKKWKEERLQARAEACRIAMVLGLQLPGAAPSFAGRVPRSEFLPLLGPGPGDGACKGKDVMERRRKSTLLGVSPRRVRPHSMQLGAENVDLHPIEAPRVSGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHN6</accession>
    <name>A0A4Q9NHN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3-oxo-5-alpha-steroid 4-dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_952417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHN6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF43">
        <property type="entry name" value="STEROID 5-ALPHA-REDUCTASE DET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="131"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="34690" checksum="E3FF56FBDF6CD7F2" modified="2019-07-31" version="1">MANLDLQTARTLYEARKWFAIVPPFFFPPTFFYDAPFGRFSPSTKSIFTVDGIRSWIAMELVALVAFSNSYLRSPLSPTSTLALTSPTRLFPNAPPLSPAHPPTLIALLFVTHYLNRALVSPLRTPSRSKSHLMVAVSAVFFNVINGSLMGTYLSSPPAQSFLADAFARPTFWLGLALWAAGFAGNVAHDEILLNIRRNAKKAAADDANNGKDKPSQEHYAIPHGLLYRFISYPNYFCEWVEWLGFALAASPAPSFASVGAFVATVSPPWLFFFNEVWLMLPRAYKGHKWYHGKFPDYPKDRKVVIPFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIX0</accession>
    <name>A0A4Q9NIX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_820200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIX0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="154"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="435" mass="48255" checksum="96E52BCE9B76BCA7" modified="2019-07-31" version="1">MSHIAAATMPDLTGCAVNGRFRLVRMLGSGTYGVVYQAVDTHVTPSDNTPSLAIKMIRKAGRMKHELAAARREIALHGLVSDHPSVVTVRDAYEDDDYFYLIMDFCRTGDLFEPICRKVYVNNDALVRKAFVSLVDAVEACHSLRIYHRDLKPENILVSEDRSQVYLADFGLATNQPIVQEFYCGTAAYMSPECIGHLSGFRPYYTALSDIWSLGVILVNMISGRNPWEKATLDDPCFIQFIENPDFLFDMLPISEGANDILRHIFVLNPLGRPSLQDLRMAILELDTFWRYDDELSVVEEYIRAPAPTLGEADLATGRLTRASYLLASMTSFKPSYETSSRDLSSVASRPQWAFDLPPLTGEGCSGDSESTVGSTTSLVSSPESSMVLTPENTTTRVELEEKDVAGRVVDPDATASSITDLLFPILNAQFRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJ94</accession>
    <name>A0A4Q9NJ94_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_822469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJ94"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="266"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="743" mass="84660" checksum="939B19DA09AA2609" modified="2019-07-31" version="1">MWLVDKLRLCRTYSLSLEPLAQNGEQWGRLQPISDRRPAWARPQVFFLFTTSFPSPEAYSDIIEKFEHQFILQHLTSIYMVIMDRYCMRLMRYDRAGSILTPWKDYTRDPTVLPDLFWRLSVLTDEQLGLDPTAIPILPGSSEDVFMDDLARKRVDTDISWREGSTIPDIIDSPDPASAPQWSYARSWFGDSIYPAQDPMAIPDFAHDHPRWKLLVPSGADVPPREFLVGVPIAFRCSEKRDVKVDERNTRVFVAYDCTARQLVCLKDTWRADKEDTYQAEREGTVLEKLNGAGVPFVPTLICDADLPGQETRTQRFWPIGDIHDCAKDPVQRAHYRLATKELCMHLCEVKRSRTLVSIIGDCVTAHASAAELVNILHADISYDNIMICPTVDSTTNPAKPTVKWRGMLIDWEFPRPVPTPENLLAVARITSRRSWKYASVEYMQAEQRALQTQDELESFFYVLLDGAVRHLPSNLESVREFVDAFFATTPSQNYPHGWSVSPWKLDALDQCRILRAPARDGSQLQFYWHSRRGGDEDGAEPIDHAFNALLQEYLSWCHGVRRVHCDSKLWHREYLPPAEPNPAIKKLDVGELAAKLDDHGAVLALFQSALKAWPEYLVDVAPPAVVKPEPREDGEAFWRAMALQGGVGEGTAPAATESEVLARDARMQMLKISAEERRERAVETRKEDAAKEKMREAGAASVKPPPRKTKPRVNLPVRSSRRIRGEPATDPDEPPSKRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJH4</accession>
    <name>A0A4Q9NJH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_979522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJH4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJH4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="467" mass="52645" checksum="E5A88CA1603AE692" modified="2019-07-31" version="1">MSEHLSTFGAYPVGQICLPGSHDAGTYKLERSTAPGGTRSNVITQTLSIYQQLEHGVRWFDIRPFLIKDSPGDAGTWRTGHFSPLGGVLDWQGGCGASIDEVINDINNFTKDHSELIILDVSHVTHLLLETKGKGLDLTVDHRRDLLDKFTAIKHVFRTTADPEHVVLHDLPLTDFIGHGEAAVVLLFDDGFDRGELHRRGFYHSSRYSVYNHYITLAQDDMAAVLSTLNPFQVFGPGANNYSVLKLTESHQRAEFPLALQNVAGSAYPSVLTIDNVLDDDLLTLSLAISFQRYNIAHGLRNKVVVYGARLIVDPGAHQRLQECIDAPRGFPISNENLGSDPWLGLKKSCAIFYWQDGWAKGRYAKEHSSLHLEQDIKSIEYGGSDVKNQGVYYRFYRALVERGGVRINNDNLGGDPKVGHRKKCKVRYREFNGKDTEEYEVDEDRYLDFKTFWERFAESQSSHSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR21</accession>
    <name>A0A4Q9NR21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ArfGap-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_934984</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR21"/>
    <dbReference type="STRING" id="114155.A0A4Q9NR21"/>
    <dbReference type="OMA" id="PANQVCF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000004">
        <property type="entry name" value="Putative ADP-ribosylation factor GTPase-activating protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU54840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="475" mass="50388" checksum="358CE7D40887F648" modified="2019-07-31" version="1">MSDPTKAETEHVFKVLKAQKANKMCFDCQARNPTWSSVTFGVYICLECSSVHRNMGVHISFVRSTNLDSWQLNQLRTMKVGGNASATEFFNKHGGAALLNDSDSKKKYSSRVAELYKEELARRVREDAAKYPDKIFVEGAEVSATPVPQGGDEDFFSSWDKPVTRPSSAASSKPTSPPVIGKAASLGTAPRTVSSASLRSTSTSTIASSRPTSKLGASRLNSSPASVASTASTAAPKKSKLGGLGAKKAATPVNFEEAERKAAEEAERIRQLGYDREREKAEAEERARVAAEQAAANKAKSPVAKSTPVTSPAIATPKGNAQDLERLGMGFKRLGFGAVPAAAAASTSAAASEDAPTYAREKFGNQKAISSDMYFGRNSYDPQAVAEAQTRLQSFQGAQSISSNQYFGREEEEDAGIGHPTDGGLLGDGSLAGLELAARDAVTRVLANPDVQNAAESIRAGALKLSDYLAQMSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NS12</accession>
    <name>A0A4Q9NS12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pre-mRNA-splicing factor Cwf15/Cwc15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_950495</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NS12"/>
    <dbReference type="STRING" id="114155.A0A4Q9NS12"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="27710" checksum="4E41A24B961CDC12" modified="2019-07-31" version="1">MSTAHRPTWDPAQAKDVKGGSRQFSVRDMAAHTKLKFRQPGQTSTAEVAKRDLRAELLAAEAEARDRKRKAEGKPPLAVESAPREGQDEQSNKRRKLLQEALELDKDADDDEDEEKGEKAADEDEDDDDDDDDDDEEEDDTAELLRELEKIKRERAEEKERQEREQSATDQAAREAEIATANPLLNLAAALGQTPNGVNTTKPGTFAVKRRWDDDLIFKNQAMSTRDKGNQPQFVNDLLRTEFHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NU89</accession>
    <name>A0A4Q9NU89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NU89"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="1">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="426" mass="47663" checksum="2AB80185F31171A4" modified="2019-07-31" version="1">MPTLYGEGHRALRRLQEEVLRRTPDQSIFAWGSTWKPSSDFHEEPDDASSVPRDKAYQLIANFLSNDSLITTSLKRFQVAHTIGAVPYDEVRLRLQLYGLLPTEYTFTSYGIRTQLPVLRLSAILHPDETEVPDDHPMSHWYLAILGCEHGDLPGHLLGRVCHILPSKSGVDLLYAGWITLVLERNLPGPYRGPDMLASSPATIEDCHSQIELRTVYISHPSRPARRSETYLDRFRSHSSIFLTLSRETRGALRAQQYNISLQRPDQAHPTTHRLTLSRHDHTISIQYDHTLKLGGEGFTMRARVESPSEVTWCNFTLWSISLGDKQVTVRAGEELAINLDLTLLGPSWYAIRVGTDRHSDATPTVESRQGEAPGPVGPQGNGVDLTSLGIFSVMSDSVLDVRFLGFGLDLAEDGLLFTGMFIGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWS7</accession>
    <name>A0A4Q9NWS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWS7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NWS7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011666">
        <property type="entry name" value="DUF1604"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13384:SF19">
        <property type="entry name" value="G PATCH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07713">
        <property type="entry name" value="DUF1604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26093">
        <property type="entry name" value="HTH_TGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="913" mass="99221" checksum="660347B9E6505FF5" modified="2019-07-31" version="1">MTSRLKRKLNDLGVDTASSKANENFCLIGTPLPPLEKSKDIGEFVPLWKQDVRDEKGRRRLHGAFTGGFSAGYFNTVGSKEGWTPSTFVSSRNERAKKKAARPEDFMDEEDLAELRESRKLVDEHEEMDFGGTAAEKRTKAGEAGDEDPITSALAATLVPPPKDSVGAKILKKMGWRLGQGIGPRLTYAQKRAQDAGFMDPSKEVNGDEEDIEEARKHLYPRKDAPVVIYPRKDNFHGLGYAPGLSLHESVGGERGSTGPNISAGFGLGALNDADDDDLDIYDGGPSGRNRMAYDSSLGDDDHYITVGSSASRRRNAIQEPSVPPGITQTFNDGTPVLKGFVLSNKPVSEDRWFPLPKVTPDWRPDPYRVWNQDKGKENEPSTEHPAQSTRSHVEWKASQLSADQRGSMLGETPLPAKTRSVFEFLSQKDRERLQSLRKARAEGAPLPSTNASTPPRPPTPGPQPQAPSGIRIPNLHPSIAKAALSGFQPFTADPLKQSRYTAFLTFLSDPSLADSPEKLGFGRFPHQSVDEFNKELEDYAKSATVFKPLSAAMAGRFRSSAVVELGPNVVEGLHQPTSYAEHVPEEKGEEPLDKEEGDPKMGAVRLGMYGPLTRETVPWHPAKLLCKRFGVKEPEVDLTEQAGAASAGFEFATGAAAAAKRDAGGAAGSSTDAGPSSAAPIAMITASESVEELKSGPRNLANIGLGEDETQGRDILTYQRPAMDVFRAIFASDDEDSDDEGEEANDKAEPTSPPFDILAPAKLKAEPSASPAPVARPNEPLEQVDLATFKPTFVPRSERESRKDKDGKGKKKDQDKKAKATLVSFDAEDDGSIPSFGPAPPKEKEKDRERKKKKRKEKHGEDEDDSMWVEKPAPEVVKNLPMPTSAAAGVGMQVDGDEAGPQRGRKRAIDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZ42</accession>
    <name>A0A4Q9NZ42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_803611</name>
        <name evidence="13" type="ORF">BD311DRAFT_646952</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZ42"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZ42"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00224">
        <property type="entry name" value="GGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="12">
        <location>
            <begin position="6"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU35450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU65290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9403" checksum="CF1D46D6462DCA3D" modified="2019-07-31" version="1">MNSRPHKQSMSELKLRRLTEHNQRLREDLARPRIRVSEASASLIRYCKTTKDPLVPSVWGPVPRADDPYQSQGGTGKGCCVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZU0</accession>
    <name>A0A4Q9NZU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_949272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZU0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19401" checksum="34D5C91821A08708" modified="2019-07-31" version="1">MPSADPNASSRIPAAHLGGFGTPGASFSYSYSNGFLRDASPSQHTNTQASRRTYAALGSDVPRVSPFPDMSGVPPAGNAQFTIHDAYSMASTLQTGQVTDHPPYDHQMTVPRPHRPCPSRSALASLIAREFQRFLDREKNEGRVLRYLGKEVTLQNLALLEVKHVSRASVQPVICLVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P085</accession>
    <name>A0A4Q9P085_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_820986</name>
        <name evidence="9" type="ORF">BD311DRAFT_747220</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P085"/>
    <dbReference type="STRING" id="114155.A0A4Q9P085"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="68"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU34142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU57734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="23090" checksum="53E88095FC27CA4E" modified="2019-07-31" version="1">MLTRTPTEILPRLWLSGLYTAVDEEQLLAIGVTHVVSVIEQRPKYPPTLKKLKTLHIPVYDIETTDLLQHLDVTTAFIKSALDDKHNTVLVHCAMGISRSATVLAAYLIATTRMQPHEAIEFLQSKREIVCPNLSFRRQLDVYAARLHRSRKLRKFLPPPLRRPAASYLPHAPLAADGIRLLRTSQSPRVSHPPPVAMTRRGSMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P0I6</accession>
    <name>A0A4Q9P0I6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_852759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P0I6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="669" mass="77825" checksum="2677219FD3D63205" modified="2019-07-31" version="1">MPPRKKMKLSDGKAGDCTKQTSISDPVVTTDPEAGASRKFRMRKGCLKDIPSFAVELQLEIFGYLQPQDLFNLSRTCKAFHSFFLHRSNERLWEASLKNDEDLPPRPPWISIPAFIHLLYSPYCHNCAGPNVRKAAWLWFARYCSHCLPQVSCSAQTVHEKLQRADTVLQEQFRYQPECFLHGIDEERPKVPQRGGYNYNYHRQQQKRYFSRHVDQLIDKWKALPERKDRDVLKAFLSERSAELRVQERYARDCEKWYEERRQDRKDELQDVREQRFDAILRLLEETGWKKELDYLGEDGLQKMSRLPVVRQSTKLTDKGWEKVQDALDDFLNDTRAQRLKEEKDRIVKERFAELDAAIVAYCVTLPRNATMNCRPLAFDLAPMKELERLANAPVSKNVTRESFASIVPKLVDKWFAKQKADFESLLRPLVKCDRVPRGVDILDLATAVFYLGGSNEPPSSRLRYPYILAQSQFRWSYGSEDLPSGHYARHVADRYNIPFTVSVIDKNKVERGIKWMRSILTALGLDPDRTTFAELEKCEGRLRCAKCKSDRRSDVVYAWEAAFVHTASSNSGKKTSYHNRWVRVKAADMARVKELEATAHEMSFNRERSAWCCSLCLEDWWSGKGNEIPQHLAQQHQIEDCRRAIEDGTVYLNPKCYALRKPPVTLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2L7</accession>
    <name>A0A4Q9P2L7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_955911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2L7"/>
    <dbReference type="OMA" id="ERISWMM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="219" mass="23306" checksum="C2D6DC3D76A27D09" modified="2019-07-31" version="1">MPPYLIVGASRGIGLEYVVQLAKRPDAVVIALVRNPAKSTHLTSAIACLKNVHVVAGDVTEYRTLELAAKQVAEITGGGLDYLIHNAANLDPSTFFKGFDDYTDVEQLDADFIDAFKIDSLGPVHSIRAFLPLLRASSTKKIIVLSTGVVRHLGVANIAAYSMTKASGLLATTKYAVQLKDEGFVVISLNPGLVDTSATAINDSASLTFEPTAISFRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4P0</accession>
    <name>A0A4Q9P4P0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein serine/threonine phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_947784</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4P0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P4P0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="23"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU59663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="398" mass="42741" checksum="BC2A9A9A33824551" modified="2019-07-31" version="1">MASAAGSCEVSDDAALPPRLSFKCAVTDSKGPRRSMEDAHSIVVPFGGVRGQGFFAIFDGHAGKQAAQWCGQNFALCLLHALRRDRSATIPDVLNQTFHNVDMNLSRLSEESDGKMHSGCTVVTAFLRLEDENGSQAFLPPDFDLVAPPLPASAADPTALVDHDRDEIPDDATNSHPNDNVHGPSSSDKDSKSKGTTSKLLHAIKSLGGVAHHRRSTSSTSAPGHPDSPNSPSPVQEKIVMPPDNVRRVLYCANAGDARGVLCRAGKAVRLTYDHKGSDKQEAKRITDAGGFVMSGRVNGVLNVTRSLGDSSMKEFVVGSPYTTETELSEQDEFLILACDGLWDVVNDQGAVNLVRAIADPRQAAEELLDHAYKNYSTDNVTVLVVRFRDPPESVRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4Z2</accession>
    <name>A0A4Q9P4Z2_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_823643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU56449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4Z2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="21295" checksum="E04F0A5A0D57ECD8" modified="2019-07-31" version="1">MKHLVVRRATPDARNLVLQLIREHQSGLTIQELYKQSMDYQQKNLTNTVEDADQDYVIPSMRYLKKVVLPELADAGQVEKVHLKRTLSAEEADKLHIGLVKSKKSTLLAGQPQWLWLWQLKAKEPEQPPKPEKKPFGAEVGVGEDFSHLNKRRQRARVEKVERDVQWMRELEKVKKEARVRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7D8</accession>
    <name>A0A4Q9P7D8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7D8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6422" checksum="38A60D4BA20D8547" modified="2019-07-31" version="1">MTWESTSARITRRTRRSTWPSRFPSPNSTTPFPEASSIIVSDGLYQLSRILPRGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9C0</accession>
    <name>A0A4Q9P9C0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145370">
        <property type="protein sequence ID" value="TBU51174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9C0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9919" checksum="02F65F7AD9C3E077" modified="2019-07-31" version="1">MPIATKQEGEKKALLVGICYKSNRNLVSNGLRVQIIARKDVKNLKEPSMGTYRYEEQDIVIMINLTSHIDDGQDQGHEHLGRRQAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA83</accession>
    <name>A0A4Q9PA83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OPA3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_863117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145304">
        <property type="protein sequence ID" value="TBU51589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU51589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23169" checksum="1BC830BAA48A4C44" modified="2019-07-31" version="1">MATAKIASLVIRTLAKPISNQIKAQAKQHERFRNLCVGLAQRMYQTEVRLRTNLLGEPAKHVRPLSETKAIESGANTLAEGFLFAVAAGLILGEQYRSTRNQSKRRDAVDDQLDELKSSVENLSSRLDALARQQEERMEEESVRHDELARILQRVVEIGLRGRWAEFEGTPLPLPLIDLTKSRATSPPTLSESANGPQDTPSPSTSSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC56</accession>
    <name>A0A4Q9PC56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145264">
        <property type="protein sequence ID" value="TBU52148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10348" checksum="8732E82DEF74AF5C" modified="2019-07-31" version="1">MARKHWVWNSQKESAGDGRTRTHPLRPYNTTTQRLHSCSLAAHTPTITDRPHPVVVSLSTIASFAMEDLRRKPVRYPEVTTGPIPVVEFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCH3</accession>
    <name>A0A4Q9PCH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_244298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145257">
        <property type="protein sequence ID" value="TBU52298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF13">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="390" mass="44123" checksum="587BD284CDCB9CEC" modified="2019-07-31" version="1">MYQQPLLSPKPPVLFLRRHTMPLCTYWDRDGNEVRLETYPSSFLHWVPGETLNEPYRAALERVEAALSINARQMDVRGLDTSRSLVLDIEFADGARRIVRVLSDHPAPRDMKRARKRFECEVGVMRWLRKHSSVPVPKIYNFGATFVAMERMPGECILNVFGDWPYSMKERAVLSYAEHALALFRLDVPQGRIGTLCPAGDALDVTPRAVIRESYCADKVYATLEDFAHALVEQRRRAAPLSPGTSAAIDRVAALLPEACSRVAESPFRRSILVHDDLNETNVLVGAQGEVAGIVDWEFHSVLPAVLAAQYPRWIRYDGALDPREGAGGTMAKYWLASPGDAARLRDAFAQYVKDRDAEYWRALVEGERLRQIVDWLSDPELEEWADCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCT5</accession>
    <name>A0A4Q9PCT5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_831856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145244">
        <property type="protein sequence ID" value="TBU52599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCT5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCT5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF2">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GS catalytic" evidence="6">
        <location>
            <begin position="137"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="283"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="475" mass="50751" checksum="EDDE231621FA7AFE" modified="2019-07-31" version="1">MPTEPSPYGVLYTPDPTASSIPAKSVDELLTPAIKFVRIQWIDFINTVRFRVVPASYFRALYANPASRPGVGLGTVALGLVGLATAPGFSPVGGYIYVPDLASWRVCPYAPGHASVMGWFEERTPSPETGLSVAICPRTILDRLVKEAQDKAGVSFLIGMEFEFILVTQIRPEVAYASNADWSTSAKLRTGSAETQALEEIAQCLLVAGIELQMYHAEAAPGQYEIVTGPLAPLEAADAVVFTREAIYNIAHKHGFKATFAPRVHNNSAGSGAHTNISVHGGNNAPRAADAASAPNLTPAERSFLQGVLAHLPAICALTLPTAASYARMQDGIWSGGTLACWGTENRESPVRLCGPQGHYRFEVRPVDGTATPHLAFAALLGAGLRGILDGAVLTTGDCPTPAFQMSDAEKRAVGLENALRLPQTIEDARKSLGLDAVLKTALGEEFIEKYLGLLQTFMAGNNDKETIEKLIEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDB7</accession>
    <name>A0A4Q9PDB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_438573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145441">
        <property type="protein sequence ID" value="TBU51022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11524" checksum="3BB529AC09E21633" modified="2019-07-31" version="1">MTSMGTAPPNEHADKPSEVTTSKKTRGPRKTTQWPPPPDLKGAKYVPLHLLTVLGPSFTRFHRWVYARKWYTDSNGTLEAFEAHYKTLSSSDRRKLGRVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDR0</accession>
    <name>A0A4Q9PDR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sin3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_793935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145401">
        <property type="protein sequence ID" value="TBU51091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDR0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDR0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sin3 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="12058" checksum="97CA38BB8ABF761F" modified="2019-07-31" version="1" fragment="single">LLYTRLHLFKNVKKEMADRSNSPFEANPLSTWSTIRAELAKLGNRLDQWSHYYELVVESCEKLFDNEVEQPAFEEMMRYMFGLKYAYKLFAVDKVIGALIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PES9</accession>
    <name>A0A4Q9PES9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_803202</name>
        <name evidence="4" type="ORF">BD311DRAFT_654920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PES9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PES9"/>
    <dbReference type="OrthoDB" id="2535391at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019789">
        <property type="term" value="F:SUMO transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042123">
        <property type="entry name" value="Zip3/RNF212-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22663:SF17">
        <property type="entry name" value="RING FINGER PROTEIN NARYA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0469">Meiosis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU32470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="230" mass="25918" checksum="A5F628030C77D124" modified="2019-07-31" version="1">MSNISQPPEFDFWEFVSCGICRLEYIKESGALSNIPFWITECGHVACNAHINADQSCAECGSTGIHVLAMSRDLEPPMSNWFESAPAALDAVGYALRFQVNTMASLVRFYKKKYLQYRPLYERLKEEHTESKRLRKLVDDLRSENQHLAQQLRGLGGEPGDMIESGKRRRADDEGRYAGQRTSSPRSIASLPTPVGPNRLTLPPSHHQPSFNSRQTHQSREPSGSQRNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEX4</accession>
    <name>A0A4Q9PEX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_938344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145218">
        <property type="protein sequence ID" value="TBU53308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEX4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEX4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="695"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="770"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="830"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="900"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="357"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="527"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="711"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="900"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="954"/>
            <end position="967"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="967" mass="102001" checksum="0EDD5363561FA72B" modified="2019-07-31" version="1">MTEVVAVACVSESSLALASEWPQILQDYLVPLLARLGETHAAPPFRMAFVTYATADTRPTPIPTKIFFGPPNTIMETMRKQPHDFGIGQTSSGGGQGMAALEGIVTAMEMFEILKNSIDTPQKANNPNLTCHLIHLACTPPDSAERPLWNMLPALDSITWDTLPGELKERKINYSNILLKPISRLSQLQISASLGSVQTPWFLVRSPHAVHITGFPQPQKGTKRSEAVGPTTEQSPEASKRFKAAASPKKAPSTPNTPSVPHATAPVAPPSSSPPIPQHAPAPAPAPAPAPAPAPAPVPEPAPAPAPSAPAPPAHPPAPSLASAPAPPFVPTMVPGVGNIAQVLSDPAQRAGLLQKLHAAEQGLRQQMAKAVELEKQGKTAEAAAVKQQFQVRAEKLKQFKIQLFQAAAGSAGGTGGAKMEPSASQSQLQSQSQSQAQPQPQPSGHASTSTKAPELPVPGPSTATGLAAKLEHDAGPRRPTPILPPAVLPGAQSSAVGVKPSQAAQQPMNPNIAAQMNKLLEQTHKLAPPSSQQQPLPTPASPQKPHAIPSHATQGQGSGRWQGTLTWRGFDSETHVRKDLQTQVIVQHPKGEVMHAEMWPAILHLAPSQHSAVPVSVLIQWLGRQQCLPLQILPHPQAPELSTNEEHFRALNRLLTEKNVYALAAWPPNKPENRLLIFPHNGLTAAFFYGPGGMPELPKTQDNQPNIGPTATANTTSGPNANANANAQTQQQALLAQFLAQMTPEQQAAFRQMPPEGRRTVISAVWARMSQTREQQQQQHQMQVQMSNLNPQQPQQPEPPQQPQLQSQGPNAWMLGGQQPNMAAMLSRIANGQGPNQPGVSNLTSQGQGQGPPGMMPNAMANLMPGMNMSGAGGIGMGNMGNIGNMNMNNLTMNFGMGMPGSQSQQQPGGQPGMGGPQGMHRRTPSGNVPGGGPGVSGLSYEMLQSFMQRSQEGGGGSNGSLGGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG03</accession>
    <name>A0A4Q9PG03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_937177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG03"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF5">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020752380" evidence="1">
        <location>
            <begin position="18"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="243"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="575"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="661" mass="70750" checksum="CC628A55AC1E2910" modified="2019-07-31" version="1">MAFWSLVFLGTLALVGASAPAGPWDAFNYAPTSRTVFPTAVKEVSGSVHNVHNLVSKGSATLIGNGSWVALDFGIEVGGLVSLNFDHVSSTSSIALSFTESPVFISPVTSDDSTYPSANQSYDGVLRVPSPLPTGLWTQPAERLRGGYRFLTIVSTSNDPVTISNVSCAISFAPHISNLRDYSGYFYASDPVSHDRNFLTKIWYAGAYTVQTNTVPLHTGRQIPMVSSPGWANNATLGVAGPIIVDGAKRDRAVWPGDMGIAVPTQFVSTNDLLPTRNALSTMFAAINPLTGALPESGPPLSQLGSDTYHAWTLIGTHNYYLYSGDDAWLQTVWANYTKAVGFLEGKVGPEGLMNVTGLRDWARLGGGGINAEGNALLYRVLVTAADLASHVNSTELSSAWATNATKLKERFNDVFWLPSAGLYRDNDTTTLCPQDANSMAVLYNLTTSPEQADSVSKGLTKNWNNLGPVAPELPDTISPFISGLELQAHFESGNDERALDLLRREWGYMLYTNISVQSTLLEGFTANGSLSYRSYRGYNYDPAYTSHAHGWSSGPTSALTYYVLGLTVTSPQGRTWQIAPHLSGLSAAEGGFTTPLGWFGAKWSAGKRSFTLHVDVPEGTTGIVKVPVAGKVTVNGNLAQSSSDGTLELAGGKHIVFVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGW0</accession>
    <name>A0A4Q9PGW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_939968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145245">
        <property type="protein sequence ID" value="TBU52592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGW0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="344" mass="39021" checksum="5F6C80D6A3C9A928" modified="2019-07-31" version="1">MAPKMQYARLGKSGLKVSKIILGCMSYGSKEWQEWVLPEEEAIKHIKFAWDHGITTFDTANVYSNGLSEIILGNAIKKLELPRDELVIMTKLFAPIPKEYGTNLAREGKKPEDVGIINQKGLNRKHIFDSVKASLKRLQIDYIDLLQCHRFDYDTPIEETMQALHDVVQAGYVRYIGMSSCWAYQFHAMQNYAITHNLTPFVSMQNHYSLLYREEEREMMPTLKMFGVGSIPWSPLGRGLLCRPSDAEATLRKKTDAYQTGYDIPFLPSLTSRIEEIAKKKGVSMAQISLAWCLAKEPVTAPIIGTTSLQNLEDILGSLDVKLTDEEVKYLEEPYQPVQIIGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH70</accession>
    <name>A0A4Q9PH70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_773576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH70"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6558" checksum="626B9BC2B2820927" modified="2019-07-31" version="1" fragment="single">MIDANPRTGSASFRASQNRTRCWETADLANITYPWTGPIFAVSLRKPGRRSADSGSATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHK1</accession>
    <name>A0A4Q9PHK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_940352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145252">
        <property type="protein sequence ID" value="TBU52406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHK1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="251" mass="28427" checksum="6F64AF38AD147319" modified="2019-07-31" version="1">MSHVLAGAPGDCCLRTVQHVGEKRGTIETVAGVETYVSRPKDGSNKKIVLFFADVYGPIYINSQLIMDYWADNGYLVVGLDYFEDDSMTKHPDREAPGFDFQGWLKRKQARAPELIGPWVEAIRKDYGSPDSKYVCVGYCFGAPYVCEFLAKDWLLAGAFGHPAFLNEDHIRNVKKPLLLSCAEIDHTFPLDARRKAEDILVENKARYFIQVFGSVQHGFALRADPSIPVQKWAREESARSILNWFNHFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHK3</accession>
    <name>A0A4Q9PHK3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protoheme IX farnesyltransferase, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_181805</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145226">
        <property type="protein sequence ID" value="TBU53081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHK3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHK3"/>
    <dbReference type="OMA" id="TKPGIIM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000004">
        <property type="entry name" value="Protoheme IX farnesyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448:SF2">
        <property type="entry name" value="PROTOHEME IX FARNESYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU53081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="447" mass="47834" checksum="F1ACC250E18F1441" modified="2019-07-31" version="1">MRGVGSPLVAYVCRSCTANLRNARPAALGLHIRLASTAVDRKQANFSAFFFDNHRWSAKGKEAPVPPRPVLQAVRGHSIDAAYSPAVETSVTTYKRAEALTPRRLAKIYVQLAKSNLTVLVVLTAMAGVALSPLPTTVPVLLSTALGTALCSASANAFNQIQEIPYDAQMARTRNRPLVRRAISPLHATAFAVTTGVAGPALLCTMVNPTTALLGAANIALYAGAYTYLKRKSIVNTWVGAVVGGIPPLMGWTACGGSLLPSSLQNVELVLPSFLSSVTTDVLAAAENPLAPLALFLLLYSWQFPHFNGLSHLVRESYAQAGYRMLCVLDPHKNATVALRHALLLVPATSILFPLAGLTTWGFALTSIVPHAICVDAAYKFWKFGGEKQARKVFQHSLWYLPVLLGLMMFHKRGMDWGSWIGLGEGGDVDDEAAGESEQTSVEAAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI76</accession>
    <name>A0A4Q9PI76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutathione-S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_939098</name>
        <name evidence="4" type="ORF">BD311DRAFT_753349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143401">
        <property type="protein sequence ID" value="TBU31148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI76"/>
    <dbReference type="STRING" id="114155.A0A4Q9PI76"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045174">
        <property type="term" value="F:glutathione dehydrogenase (ascorbate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
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        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="112"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU31148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="255" mass="29458" checksum="5DB994653567AB05" modified="2019-07-31" version="1">MGVPDEQIHPVATGRAAQTVKQHQESQDLVFYSGWFCPYVQRAWIVLEERGISYQYKEVNPYKKEPHFLSINPKGLVPAIEYKGRALYESLIICEFLEDAFPNYEPHILPSDPFDRAIVRLWTDHVNKQIVPANMRLTQAQDPQKQREHLEELNKALRTLVEKVKGPYFLGEQFTLVDVALAPWVVRDWVIAEHRGYSREAVGGGWKEYAAQLESRESVLKTSSDKVHFTEIYARYLRDEAQSEGAKAIRAGRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ11</accession>
    <name>A0A4Q9PJ11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_798738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145198">
        <property type="protein sequence ID" value="TBU54055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5737" checksum="F2F741A92C44DAB0" modified="2019-07-31" version="1" fragment="single">PRTTGQSPRTTGQSPRTTGQSPRTTGQSPRTTGQSPRTTGQSPRTTGQSPRTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJJ1</accession>
    <name>A0A4Q9PJJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJJ1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJJ1"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="344" mass="38301" checksum="D3D21D593919962F" modified="2019-07-31" version="1">MKKTRSLPPTRHTNIDGRRTIRTTVTIVNLRHVPNVTERPLLPFSWGYSALLALVPIIVSVLGCAGCIFVADWFCLASIALGIVANGLSCFVIGSGNLTFEHHEPAEKAPPGDGVLKGDSDVVLLIGREGAINAFVRGRFTLQFRKHRFVPPQGAIGPCAILLIVQFLSQLLLIPQGTLFGQIMFVATLGASWLYNVFLSSIDREGIQTRILFDVLKIDEEKDIQKYELNTWTETTAFTCLVLAWVNHIKAPSELLDGMLPNNTLVWRAWKETMARKLRSQALFRRNTGFNFTDEDWEGDGLDPADRDLLQTFLTDSENAWKAWTAVRDTPQMKGLRPLVGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJN5</accession>
    <name>A0A4Q9PJN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_79717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJN5"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="33462" checksum="E07605D73DB4C631" modified="2019-07-31" version="1">MLLGPQNKHLLLVGRVLKRRLFVRRSGIGCKLQRTYSLERDSTGRMTCPRYTQRSSTRRLHTQLELWQSHYLNDGRGAWQAPTSHVGEHRAIQHGGIYQAEAHRQDHDGPYANLNMMRTHSPSPIGSQANSYHPHPEEVATRPAYSYRSPPEVLGLSGSYEDGKAMGVPEARQEPNGFPADVVAPQIALHGRTGQPTGYPSAFEQDENMEAERTLTQRPPLPASAASHAAGRAVPPAPALAPGAEPAPPSLSSAGPVVAESPGATSISRPAAQGLNADPTANAPAETKKRKKRFLPRIEFKLRLVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJS6</accession>
    <name>A0A4Q9PJS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJS6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="18591" checksum="B517A3A084E296AA" modified="2019-07-31" version="1">MDVSTRDGKIRCPLCFPRIHYHRLFHLVPTVDTDSDNDAEDVPPDGNGDEHGSDVDAPAPICARNDTAPEATSSLDTANENNGKYQREESGKAKGKLADVPAKKELVKKLTTLDKSAMDWRAHVQGGVSAKLGADTVPPCKSVQMPAAPFRDRRQRVRVAHSATRVPALAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJZ2</accession>
    <name>A0A4Q9PJZ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_980372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145189">
        <property type="protein sequence ID" value="TBU54437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJZ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020403622" evidence="3">
        <location>
            <begin position="17"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="101"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="428"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU54437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="571" mass="62567" checksum="C3212935BA159265" modified="2019-07-31" version="1">MAKIAIITVAAAVSVGLHLVNDLYAPEPEVLYHTAHASAPEFDWHSLEPSTEIKWTSCYNDQKCARLLLPLDYLSEDLSGPTTAIALRMIPARDRTNYRGTVLINPGGPGGSGTDLLARAGKNISTIVGDSFDVLGFDPRGVGASIPTLNCFSSKGQRDIWLTQEGHQFLNTSDEALLGLYRARQRVVGDRCAESDGGEEGIARFMSTASVATDMLKITEKLGQEKLHYWGFSYGTILGQYFTAMYPDKVGRVIIDGVYDAYNYRGALWNSNLLDNEAVINSLFTYCHEAGPLKCALYESSPGKIRERYYRVLDRVERDPIPVPHAEPPLLITRKALVNQIFRAAYKPINTYGTVVDTIRAIETANQTALTALAPKIVDPTECACRTELPQIVENDAFSAIACGDGEERTYDPEAYKAYYADLTSDAPNAGPFWAVHFLQCTEWSVRPKWRYTGPLAAANTSHPILILQPKFDPVCPLRDALAVRERYGGAGLLVQNSYGHCSMSAPSVCTAKHVRAYMEDGRLPEEGTVCEPDELPFVGQVSDARAMSGEDATLSEALRGLSEVVPMFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKW5</accession>
    <name>A0A4Q9PKW5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_730525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKW5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15575" checksum="8BC8BF9848534808" modified="2019-07-31" version="1">MLIDTGCSTSELPQNAIQRLHEVLGRRTTTVPKPSRDPNRRETYHVSTWVLDNKSQVKFEFGGDPDEPPIIVYGPTETFVYPDEMLPGAGENNRLEGLIFPMVEDKKHGILGLNFFQSMFVAMSKAENAFALPKETNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM58</accession>
    <name>A0A4Q9PM58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_692157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM58"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10833" checksum="E208ED09E7E2A1FE" modified="2019-07-31" version="1">MIARFPAIARVTFIRQLSSLRICYYIHRSCVSMCQERSGMHHDRTSKATTVGFQTHLAQQGSLLAPTAIRANPPTCRGGSDLRIMTSHLRFGNVDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNJ5</accession>
    <name>A0A4Q9PNJ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial</fullName>
            <ecNumber evidence="13">7.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_932926</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.2" evidence="13"/>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNJ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNJ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
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        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Nqo1 middle domain-like"/>
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    </dbReference>
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        <property type="entry name" value="Nqo1C-terminal domain-like"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="5 13" id="KW-0285">Flavoprotein</keyword>
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    <keyword evidence="9 13" id="KW-0408">Iron</keyword>
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    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="13" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="13" id="KW-0813">Transport</keyword>
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            <begin position="370"/>
            <end position="415"/>
        </location>
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            <dbReference type="ARBA" id="ARBA00001917"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU55745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="500" mass="54764" checksum="284A3C0C79E1C431" modified="2019-07-31" version="1">MLRHTAQATRIARPFRAKLPRRSFATVQDTPVRRYGGLKDQDRIFTNAYCRHDHGLKGATSRGDWHKTKDILLKGDSWIIQTIKDSGLRGRGGAGFPSGLKWSFMNKPGWEKDPRPRYLVVNADEGEPGTCKDREIMRGDPHKLVEGCLVAGRAMNASAAYIYIRGEFYQEASHVQQAINEAYKAGYLGKNACGSGYSFDVYLHRGAGAYICGEETALIESLEGKQGKPRLKPPFPADVGLFGCPTTVANVETVAVAPTICRRGASWFAGFGRARNQGTKLFCISGHVNNPCVVEEEMSIPLKDLIEKHCGGVRGGWDNLLGIIPGGSSVPVLPIDKCAEVLMDYDSLKDAQSGLGTGAVIVMDKSTDIVKAIARFAHFYKHESCGQCTPCREGTTWMMNMMDRFVEGRGHQREIDMLLELTKQIEGRTICALGDAAAWPIQGLMRHFRPEVEKRIAEFRAANGPVLFGGRLKSQTDPTLAIPDNLGANLPEVPPPSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNT4</accession>
    <name>A0A4Q9PNT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_824820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNT4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNT4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0472">Membrane</keyword>
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    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020315741" evidence="3">
        <location>
            <begin position="25"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="419" mass="44886" checksum="56A632BE8244F1E3" modified="2019-07-31" version="1">MLQYPCRSFVSITFFSFAFNFACAATTVIDDRSQSIQWNGAWEVKGNQPAPTWDGSLHWGNSPGLTATYTFTGTSIQVVGAFKPIGTWIMKSQYTIEDGEPTVFTPPPEVTRASYAQTFFDSGPLPAGEHTLLIRNLGEQLWIDCLRVSDDPASITTSAVGTLKIGNFDHPNKTSSRLPSSATTTTFSTTSSSTLVQPIDSTSIVTTSWVQLINSTSIVTLSLSISPSTSSVIDSNSQLPPSFATSSSASSTIQAQETTPTHSPERNRAQVNGLSIGLVVALVVVLGTLLGTTCWYRRRPSRNRTPVQPYASFSSEALIQHDSQPTVPILDDNSGRSLSSASLNLSLPISRPASSVVGSLNEHTGDIDIRRQSQVSAQWSVDGGVRIAGGPYGGDAPSIAERQNLKDKFPPPYQAYPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP94</accession>
    <name>A0A4Q9PP94_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_960480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP94"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="89"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="300" mass="32845" checksum="ABBB9D50F6B5F908" modified="2019-07-31" version="1">MDVVATFKESTIPTFLDPTRQAFAKILENRLPEIENHPRQTFQFGSTDRHQLDIFYPDPAAVSSGGPIPQAPPFDLVYTNVGVFFAKRGILTVIPDYRLHPSVNYPAPVEDVRGALAWFLANPSSIISASNGTLSSTADISNLFMMSHSAGSIHVASLYISPSLLPIDSPVRAATRGLIPTGSAYMFSFPNAVTPPGLLEAYYGSQEAALESMPITLLKRASEELIKSLPELFVLKSENEPEAISKGNDEFVKALEGRLGKKVQYEIMKRHHHISPHWALLSGDGDDWGEDVAAWVKAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ74</accession>
    <name>A0A4Q9PQ74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ74"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17670" checksum="5BBF6B26BF46E253" modified="2019-07-31" version="1">MMVPSCEHMDDREAGRCDRHLACPSSRTAHAFARHARTQPPPHSTRSHPGWALSVSQLCRYIGEKSRGKADWQAGGRKAGSPPSCEEKRRQRSVSGDGPARIGNVCSNRQLYTVPSMASPLPGSKGSVGKESDPWDATQKLHMHQGRTTISRHCICSETVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQG9</accession>
    <name>A0A4Q9PQG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQG9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6385" checksum="EBB18B147B990F88" modified="2019-07-31" version="1">MPGLQVLIRFEYQIPRTLGSADDMGQQLYVICFVLCAAYLALAYGPRELFGRVRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS74</accession>
    <name>A0A4Q9PS74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_1020677</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS74"/>
    <dbReference type="STRING" id="114155.A0A4Q9PS74"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="290"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU57262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="584" mass="63640" checksum="885F42C92AACF1BF" modified="2019-07-31" version="1" fragment="single">AIVRRAGPQDLDASVVFWADIVIICVAGAFFLFTLPRAVARFGPGGGWLDGHFFRSRRHVRNPRGTVSSENLTRDTHSGGITPSSAVSEKAVQVRNPLHMRAWQARFPGAMRILRYPMIGRIHTGGVAICALYFGLLLFAALYKSSIFKDPQRAGLVAASQIPIVYVLATKNNVLSVAWGTAYDKLNYHHRFAGRLLVLAANVHAIGYIYLWTREHRWLRTIAQPQYAWGLTALILLDILLLFSLAWFRQKFYNMFIFTHVIASIIFLVAVSLHMSQAVPYVIAGAVFYGVDRIVRLLKTRIATATVTTLPEMCMTELTIPSINGGWRAGQHVRVHILSTGMGFYGWLESHPYTIASAPTVAHGAPEGLVLLSKNCGRWTKALHAIAAANTKGVESGSHVKVLIQGPYGGPGYTLPHSFSGAMYVVGGSGISYGLAGVQEVLQYARAGSNTVRIIELVWSVHHPDCLTPLLPTFSSMLAQALALDIKLTISVFYTRAVTSDHEFKEYALSPGLALEPGRPPVNHLVHDVVGRTLHAISDRGERRGVFVGACGPGSLGDAVRNAVSDLDVKGQSNLVGGVELHEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSJ7</accession>
    <name>A0A4Q9PSJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_949487</name>
        <name evidence="2" type="ORF">BD311DRAFT_669532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143460">
        <property type="protein sequence ID" value="TBU25483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSJ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13510" checksum="770E01732FD31EBC" modified="2019-07-31" version="1">MRGEREQTAYQKSPAAHATEMPSRKTSEGHRVCDLAVYPLAVTHMLVPRPIRLWRGLRRVAEKLTSARPRPEGTANSAPTADRGLAMRRRVDVLGWLVHASASVPREHSRFADLGDTHARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSN2</accession>
    <name>A0A4Q9PSN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_880865</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSN2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="330" mass="36496" checksum="CDE26DF4BB167652" modified="2019-07-31" version="1">MSSSSESQAVIVEADVVQLYCQVATLALIAYEYVATFASEVTFFWIPHQVNGVLVLFLLNRYLTMTTQIMAWAPLPSSFQSIVSQYDAFYFTQSVQYLPWAAFSTFRSYALCPEPYRLFISATVLSLAAFPGILNLVTTLRFVSYVRDPVYGALPVHELSESMNKRLTIISRSLLIGADLLVLCVTWYRTYETVKFSRRDHAGTSGRTFSGTLLRDGTAYFLTLLVLNCLHVAFTLASVTPSEQDLDPASLMPLFSEPITAVLTSRFLINLQEVKHKLAGSSRSLSGGELEFQHNASGNSDGFIGSFGRELSFGEDNVGDEDVAEEAPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSV9</accession>
    <name>A0A4Q9PSV9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_929255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSV9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="193" mass="21551" checksum="96334F93C823AD66" modified="2019-07-31" version="1">MTQSRRGRCGPSTSACLSRPCRSHRCASRERSAAVIGTGPSAPRTSQWMRKQTHYQTDFVDDEMRRMWAMEKMELSSLRCFRCCSPVGASGRYRMVAVTKAEARGELQKGDARLPERKCYSANSVESFESGIAGRAIIENGMRSLQRGTTFAREVQGLLVLLVTWISTNVRNDKHILASTSRENTSTRHNSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU02</accession>
    <name>A0A4Q9PU02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_879827</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU02"/>
    <dbReference type="STRING" id="114155.A0A4Q9PU02"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000002">
        <property type="entry name" value="Molecular chaperone DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="375" mass="41813" checksum="4ADA2D3A1687C58F" modified="2019-07-31" version="1">MGSLTCLLFLVLSLVLLVHAADLYKVLELSKSASEQDIRKAYKKLSRKYHPDKNKEPGAEEKFVEIAHAYEVLSDSTKRQIYDRHGEEGLKAHEGGHQHHANPFDMFQSFFGGGGYGGHQVRKGPTSTSEFEISLADIYTGASIDFMVKKRILCDHCRGTGAASSSDIHECKACNGQGVRIVRQQIMPGMITQSQVTCNECGGRGRVIGKKCPHCNGNKVMDHTQHYTLEVPKGAPEGHEVVFEGEADESPDWEPGDVVIRIRSKKERGGWRRKESGLYWKETISVEEALLGFERNLTHLDGHIIELQRHGVTQPGYVQTIKGEGMPIFDTPSEHGDLYVEYNVVLPTEISPETKKRLYAAFHPEATGSRPTDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUI7</accession>
    <name>A0A4Q9PUI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1039322</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUI7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUI7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043490033" evidence="3">
        <location>
            <begin position="20"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="585" mass="65693" checksum="91E29BFD6DB01A0B" modified="2019-07-31" version="1">MDYRTVLYVLLTLVSTALGQNVSSNATNSTNDGSYPYDPVLAHRPNFARSLPIQILLLGITLTLTAVLIIHLIFTAQYHWPLAPVNCILQMSAVTTLLISCIATLHVVLSSTVSQSMTWPYMLDYIAVELPPLTEENSDWVMGELVAWLLMNATVSGLIQITHIQFLTLLFPSGLERRLIYCLLGPLAIVSSIMHVLRISNDAQLVKGASAVQNICNATLTLLFTSALVLWGCVINRRDAWRTDGGTAAFGAGAITLALISTALTFFYIPSRDQYAWMPGLMWAVFLWQSFLGWWWWVGAGMGVGAIEELLRREEKRREKRRAKMAKRKVRKERAQTLWKGVTHVFYTGRQESQQPQPQSDGGSSSDSTFSCEEGDGQGRRQRTSGDETTVGGDSVRRVTSRQTDASSRSGTTSSGYVSRFLNQHRAGRYVYGWYLGLRHAHLAAAHEQAVERVERINQAYGPDAQEGGRAAFGWGLGSFGIRRHERRQNERHNPPGEYEMDEFESDEDDQRKPWPSEATPAPSSDMTRGEGEGEIRARRWVARTAISNTRTAMTPDEDSHRPSSMWWWGPLQRWRLQDATDYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWV4</accession>
    <name>A0A4Q9PWV4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_818006</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWV4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWV4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="97"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU59163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="303" mass="33707" checksum="D06DAB040F6441F1" modified="2019-07-31" version="1">MASEGRPSLPRLVFSKTKEYGAAALQRYRNLNTYQKLFVWGTICLYLSLATLFIVIGPDRIGQALYNFAQRISHFRFGWLILTAIFFVISFPPAVGHTTLITLCGYAYGMKGFPIAAGGSLLGSAFTFVVLRLLFRRRLRKWSESHETWKALETVIAAKGLPLIMLIRASPFPPWVYSNALFASIRPVALWQFFLATFVVFPKIAIFVFVGSRLADLSDGETRSHMDTTTKILNVSISVGGVVIAALASWIIYRLMKREILHLKGVPPEVDELAAEAIEEAEEGAPLLGPHSESRARYDDSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXE4</accession>
    <name>A0A4Q9PXE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXE4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9099" checksum="1BD19EA5004CA2A3" modified="2019-07-31" version="1">MEGVIAVNLADEVQPLRTSERADRTYTSRAPSGIRSMHEYVLGASVLWMSAGLLGYLYTFMEIYRIALQRECEIVRTENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY40</accession>
    <name>A0A4Q9PY40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_924406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY40"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY40"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057860">
        <property type="entry name" value="HEAT_RRP12_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25772">
        <property type="entry name" value="HEAT_RRP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 N-terminal HEAT" evidence="6">
        <location>
            <begin position="15"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RRP12 HEAT" evidence="5">
        <location>
            <begin position="346"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1153"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1052"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1255" mass="135779" checksum="045803A55BDC09E1" modified="2019-07-31" version="1">MADNVETALAKIRPHTSSALAHQKAPATLLRAIEATFREQNTEPSATAYFAALLTSLDGSLQSSRASGPALGDGDLLPAVLYLLAAVTPYVPQPVIRSHLSTIITLTSPLFPALSAHAPPLRSQLTLYGTVILALDRSQLDSQGLRQAFMTILQLTLDPRPKVRKKAAEIVKDVLAAPPPPSLKHPYAEKVAEWVKAALEEVCAGGLPKFKGKKAETEGSDAAIHLLAFLRPVLPSLPSESLSSITSSLLLFPRLGNPYLSQSAYSILSELLALSMDDPTVNLQSHMSELLKVILSAPPLRSDAALTAAWANVLGSTMLAYHQANPEECAAELGKVWKAIWNLLESSDAATRKAAADALATLGQCFTTTLIKAAVKEKSSDEPKSAIGKIIAQSTKALDSLAYARAIPDILAVVASLIENLKSRNGSRKNTTAAEQLLLPLITKVADLRVQKTFEYKETADATLGVAMRVLGPAVLLRVLPLNLEQVDRQAGREPRAFLLPLLAQPHPSPLGHFVSYFVPLTERMFELQSTAETEGRQSEAKVWSVLIEQIWVGLPGYCWGAPDLKQSLTAQFSQLLSQLLYGQPVLRPAVLRALKVMVDSNVALASEDPDRIAKLPESVRTDPITAAEAQANIDFLRSQAESWLAVLFNVFGSVGRDNQHMVGDVISSWIAIADAKEVTQAYHKLVTLFKQNLVKAQSAPAPRGPTSDSVTVMSQDLLLLVLPYLSPEDATALFDMFLTSDVLESRDNGVQKRGYKVLTRLVESGKVQVDAAVVLKKLEGLVEDLAAAAKKDRFQLLAALIAVIPQDALHLIPSIIPEAVLGTKEPSEKARNAAFDVIVAMGRKMAAGGVVKRQMLEDMADDGAGEAAGNIEEYLTMVCGGLAGASPHMISATVTAVSRLIFEFKNSISANMQSEIFTTLLVFVTSANREIVKSVLGFVKLAIHTMPADLIRPHLKDLVPALLKWSHDHKNHFKAKVRHIFERMLRRFGWEDVYACAQEEEARKVLLNIKKRKDRAKRKRANAADDEDEDVPKAKPAAGDAFEDVLYGSESEIEDSDEEDAPAQSAGQAKRKGKDAGARLRVDDDEPMDLLSGAASRVTTANAGKRKKPGQDAAHFKIDGDTGKMVIDDSDEEGAAAAGDEDVEGNAYREHLTSVDGFTRGPNGKIKFNKDTKKRRRENEEADGDIEMADGEAQKAAGKKTKRKMEPKLGHEFKAKKAGGDVKKGGVDPYAYLSLSQAAKKQNRGSRIGIAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYF6</accession>
    <name>A0A4Q9PYF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_958343</name>
        <name evidence="3" type="ORF">BD311DRAFT_865456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143421">
        <property type="protein sequence ID" value="TBU28518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYF6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYF6"/>
    <dbReference type="OrthoDB" id="2801792at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU28518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24861" checksum="9FFAA10AA00C428F" modified="2019-07-31" version="1">MSAYGTTYQSQGCYTISGYTPTCLRQEEAWLHATSPTVHGDPRLLPHTLLNAGYCFDSFQEQMPSGHHNASLVPNPYFPFTAAIMSAQSTSPSTSPIEPKMEYVDYAGIPPSTSTQHPCDSHTLGPVGICEWRGCNVQLDDLSHAGIRRHFRAYHAQPRGSTLRCQWGVNCRSEEMLFDNIAKHIAECHLKSMKRECSTCGNSFARNDTLKRHLNAGCPGLVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ86</accession>
    <name>A0A4Q9PZ86_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trimeric LpxA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_356912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ86"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZ86"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29900" checksum="34810613B99A3EBF" modified="2019-07-31" version="1">MKRAFDVIGSHYETTSIIWRCMGAKIGKRVYWPGSGVYCPDPELLEVGDDVVFWSRSEAFTTDAHGSGRIVVKSGAMIADRVVLLPGVSVGKRAIMGSGALAKRDMTYADGSVWMGSEGGEAVCFKSGSKEATHDDSPTITPFGRAFYKREATYFVFPYPLLVSINTLLAIIGAGYWSIAAVVGTQVLNQFRIHLPRLDLLASGPQQTFVIFGLIACWFILTLVLQAVVVILWVVVMKWIVIGRRAPGSYDWDKSSYCQRWQLHLVLAKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q124</accession>
    <name>A0A4Q9Q124_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_265731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q124"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="266" mass="29707" checksum="40E2094BE53EF6AD" modified="2019-07-31" version="1">MNNLPRAGARKEVRWADLVGSVANSPTEVGAATSIEEAPTDHTAATTTDIARYVHTRVVYEEIEVNSSESTPTSEPVPSAPLMRTVELPPLLAPQTSSVHALHQVLTSAQYAWDVRTLRMPNINDTVLEEPAFLFTQEVKSFAISLHPQPFTTAYDDTVVVIAEYEGEPISVRQVFAQMLAALYKPLEEHDLPSVDALRPHAEWAATVRAKHTSRRDVLRNVDLYPAERHRPGLWFHGINVEEDTHGHPRYEAVFCPYSPITERQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1S5</accession>
    <name>A0A4Q9Q1S5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1S5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9760" checksum="4EE5B7CE19F28F24" modified="2019-07-31" version="1">MPEFPNSEGLVAPAVGVEWIAVTTAEWRRIRKVPSQVRCHPACMLRTWSPRSCGEGTSRNCLRSCLRTYVLSLSMFASSALFRGERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1X4</accession>
    <name>A0A4Q9Q1X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_270925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1X4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9445" checksum="3E0D5012BC7A6F17" modified="2019-07-31" version="1">MHPMSSIIIENRLTTRPSWTNGRIHSSEPTPRHYNEEATLSYDRVNALVSAWLRVRLRINDLRDAVHAPVHFTKSVRVTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q214</accession>
    <name>A0A4Q9Q214_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SH3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_921078</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q214"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q214"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF3">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0728">SH3 domain</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="164"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="280" mass="29205" checksum="D859901739E51F6A" modified="2019-07-31" version="1">MVFARLTPQDKDAFFSLLDEYFASRPELFGNGGSGMTNGQRAAAASAVHQAFSAAPALAVAAPAVNGWRRPQQSATTDSPAEESTPVAGRVAAAAAALRAANGGPAAATPNQNGFPRPPPRRAPSSSEESATLGSEANKLVASRKFGDVDLSSGKNMFSSIRGSTAAKHAGPAQVAPPTPPAFKRNTEFAPPPRRVPSTGSSVTAASPTPPPALPRRQPTHEESGEWAEALYPYESDDPGDLPLEEGVRVLVVEKTSDDWWTGEIDGRRGLIPAAYVKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2H8</accession>
    <name>A0A4Q9Q2H8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_813988</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2H8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF14">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="190"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1069" mass="121035" checksum="D614F617637D03F2" modified="2019-07-31" version="1">MSPEDAAPPVATLVPQASDVQATDFQAPKPVVVAHPQRLVGFLSPLPWGVQWEIARYVNTGFDYSRFTISKLKELKNMGKNSLAAPEVTKYVRQERKASAAEGDVHDVPHDEDGDDASDEFADAYSREQSARLPWDELDREDEILPNHQYGGLGCNEHEAYNESDPDWYGGKVHFTAKVVVAKDRRPSEFRFILERPALGSSNRLMRRFGSRRFIRARIQKDALNQKGNDLAEYFRRPFVIGGAVFRAFFAKEQNVFLVRTNEAAIGSGEDVRISTPDSSAATEMSFMQFIEWHNSLLLNSDQTMAKWAARFALPLSNSMPGLRLKHDNVKFVDDIICDSFEGKGKPPSEMQMTDGCGFANRAVMRMLHDKFPAWQDEPTAIQCRIGGAKGLLLVRHDLYSSLPLEQCILPSDTDPAKLTLDVLRASRMKCPARLSTETITNFAENGVPYECFSKLFQINLEDRVNALLKWEPADTNGSADTPQPDASAMKLLWHALAREGGVVAARLARVDSGRARISGYVADDQEDEFDDEDGLSQLDTALRQQSSAWWEDPISGSPSSLEETCMTLIDSGFRPDDCAVLGAKLREVAKKVVKTFQTKYRFAVPMSCSAFIVPDPYGVLKANEVHVRSSRRNLPDHQGRLTDLVLGDVLVTRHPCKVPSDVQKVKAVFHERLRHYCDVIVVSTESQTFRGEPLNRHLASLTGGGDYDGDTMEVFWDPDIVNAFHIPDPRVFAVEPPMVRACLQKNTAMVTEYLSQIPSTASEEFKIYSLQKYLLGALQDKSLVGQYSTWWENSTYANGYNHRDTIFLAYMFCAILDGSKTGVTVVPAKYKEHCRNQVWQARPPAWKESEEDREREELARTFRRQVQRPDTLPRFIMDRLRACVDLACTTQRRIIEKRLPPDFIPPRDDALARPWEEACSRAEELAARGCNLMREELDAIKAHVKAMYTRGKEMLHAAAREQKTGHFTELPIEKRQDALRKLSREFHSRPPKLLFFDAASARRVKSSYAYIYDYEHSRGKWSRFPWNVGTRALCEIKAEALGYPKTIAAEFYSWMAISPAYIRKYSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2T5</accession>
    <name>A0A4Q9Q2T5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">tRNA modification GTPase TrmE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_921166</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2T5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2T5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14858">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.120:FF:000007">
        <property type="entry name" value="tRNA modification GTPase GTPBP3, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="entry name" value="tRNA modification GTPase MnmE domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003661">
        <property type="entry name" value="PRK05291.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42714:SF2">
        <property type="entry name" value="TRNA MODIFICATION GTPASE GTPBP3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116878">
        <property type="entry name" value="TrmE connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TrmE-type G" evidence="8">
        <location>
            <begin position="322"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="569" mass="62324" checksum="89EE2DF2A69A0E95" modified="2019-07-31" version="1">MHGRTLLRTRTVCSLEALIHFAEKPSYRLPRSTITTNGNRYRIAGPRSHHFALRCGLLRLYSTSSSTSNVSAGYSWDPANSRSDREPPELVSSDAQRRTIYALSTPPGKAGVAVIRISGPDASKVWSGMVRTRAAGNGKAREREPEPWRMHRCSVVHPGSSEVLDDGLAVFFKGPKSFTTEDVLELHVHSGRAIISSVLNAISFFPFCRPAERGEFTRRAFEGGRVDLTQVEGLRDLIDAETESQRKLALKTAGGATRARLEELRNEIIQCLALVEALIDFGEGEDIEEGVFDQARERVLKLRDTIQHYLSDNRRGEIMRSGIRLAIFGPPNAGKSSLLNFLAQREAAIVTPIPGTTRDILELSLDISGLPVIIADTAGLRKTDDIVEQIGVERAKQLVQSADVSLCVLSAPEVVVSSAASGSPLNIPPTVVPLMKDDTIVLLNKIDLLPSSLSLPSAPAQATWGVSLSTGQGTQTFMEQFGEVLRHRYHILRDSGVSAEEPLITHARHRCHLENALKFLEAFLNTPPEEVVFAAEELRYAAQAIGKISGLIDVEDILDAVFRDFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2Z1</accession>
    <name>A0A4Q9Q2Z1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_812544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
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            <dbReference type="EMBL" id="TBU61627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="18454" checksum="60E99AFED32E5D00" modified="2019-07-31" version="1">MSFLYSKLIMKPFVAALTAAAIAATSYASVLHAKTVSNTSIAVGDKVVELVELSCGSAPVTKRQISPSDAFGDVCISECFTGGSIPATEDCQTVFNGIMTKNSDSPTFRLAGGSALVLASGTCEFFFQNNDESTDEFCWILLAQTGSALGSTCFANGASEGSCFTNTEPMWDFLCV</sequence>
</entry>
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        <name evidence="3" type="ORF">BD310DRAFT_176645</name>
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        <name type="scientific">Dichomitus squalens</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="516"/>
        </location>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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    <name>A0A4Q9Q3V9_9APHY</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        </location>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="TBU61596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="571" mass="59882" checksum="8346FA34EDBC4BAD" modified="2019-07-31" version="1">MYALKPTSFFRPSSRPTSPVPAPRQEVPVVGDRAARPLSKLSLSTFRKPSPSPVSLPAGAAAPSTVVQDGSFMEVLSLKLSEAVSRALAQPTGPAAPGELLAGRRPIPSGRGRALGALIVSEINASRENPHVYRAVIRTLQRPLSVLSTNLSSNLVSLISSPAFGSPAAPTPQNPELNATQLHAVSLATFAGELLESFDEIGLGFEVDTRGESLRSIREGLVSIVKRVVDPLIAGIKHELLPILDALETAPSPPVGPTSSAGKSSGGIKSPVPHPAIMTLQATIPIHARALSRIVASAYAENALASLVISLIWRGMVALAHRPTLLPSPPSSPSMGTVALLKSKDSKKTLGGQTPASPPATPPASRFTLKLPPSRPPSPPSVISRGPTVAADARTLYNLLNQLPKPSLSKEQTRLAREVVDEAFDGLSAFIALLESIQVHTPPVRSSSGTGSANTSPKVTPLADLEADLDLLTADIPIVIALPLLLRTYLPGERSVPAILGLGEVEYRKNCLSGFGRAEECGVAVGQRVLDVLRAQGSGGADAEPLLKWLERELKTARAERDEGDVVMHGH</sequence>
</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="TBU61636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6446" checksum="2CE7FB1E47ECA661" modified="2019-07-31" version="1">MAALRHPSSCLRASSKSPACLCCHSGCSRNQRICSEPCQSAPARFSRHSADSPLARYPTP</sequence>
</entry>
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    <accession>A0A4Q9Q443</accession>
    <name>A0A4Q9Q443_9APHY</name>
    <protein>
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
            <dbReference type="EMBL" id="TBU61811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="12058" checksum="E84C5AE495CBC369" modified="2019-07-31" version="1">MRSFPFHQRAIWAFPAVLKDHVTARPSQFNIAPVVGLMWRCSRADDVGSNSVGPTGQANAQTLLYFANRLRCCDVRNQTYLLRIPLPSHYVEEVQKPGWPACFRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Z7</accession>
    <name>A0A4Q9Q4Z7_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">BD310DRAFT_946181</name>
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    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Z7"/>
    <dbReference type="OMA" id="REVIFIC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6882" checksum="8CF3ECB768B50B9F" modified="2019-07-31" version="1">MPSFAIRQEIQMRFNVDRRHIYDWFHSKGLRVTKEDKRATVEQKTDAMRMHVSSSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q566</accession>
    <name>A0A4Q9Q566_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q566"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="219" mass="24439" checksum="8643A72D262B00B2" modified="2019-07-31" version="1">MGWLSRAPGRRGRIICCLLLRPVDHSSAWQRNLHPRSYVAPSAFTRSSVASTVAVFALTGYLRRVKVILPVTSVISNPTDSSIQEALVQFNALPVGQGHRLRHEYAIASSLPRPLSTPDRLRARHSFARPTSLRRPPSGPARACARKTRRPRRECVQPIGCTRSRTSHRCGEGGGVELERRSHLGLWTDGTRWGHSSHHSTLPACGTYKQCGHWGWRVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6R3</accession>
    <name>A0A4Q9Q6R3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type 2A phosphatase activator TIP41</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_869801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIP41 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6R3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6R3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051330">
        <property type="entry name" value="Phosphatase_reg/MetRdx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007303">
        <property type="entry name" value="TIP41-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021">
        <property type="entry name" value="GAF/PUTATIVE CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21021:SF16">
        <property type="entry name" value="TIP41-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04176">
        <property type="entry name" value="TIP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="303" mass="33956" checksum="A7AD43B3385FC742" modified="2019-07-31" version="1">MSAAVALPQHRLLESPNSRTIEIGPWTITASTNPISNAGQSDALQAAIGGIPLPEMTFGNNSLELEHKTSGWKYAFTTEEALKGVKNGELEDGDGGVKVGYADAWIKSRTNPLSQIPMPTTVPTKPYDWTYTTLYPGHLKSSSKDIKWKPAERNNTKHTIPLAELTRHDPILFYAEIPLYEDELHDNGASHLLVRIRVMPTCIFILQRFTLRVDNVLFRTYDTRIYHSFASSPSLVVRETSGWEAPYERVKVRLPRRDDLTPLTDPMWIAKILSEMPSEISREVGAGTKWRGLGTKIEVATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7E7</accession>
    <name>A0A4Q9Q7E7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_918589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7E7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7E7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="156"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="492" mass="54756" checksum="7A70585BEDDFF237" modified="2019-07-31" version="1">MSNFTLVDPKGWDCDLQSVYSAYMGHFQLHNIPWYDRSWGIFFESFEEFLTFSWPTITVTDAWTGRAHIVVRISAVGAFLKMLKTRFGETLPMVENILRITPFETSQRHMRTISEYATYKKVFQTLPAVLLAAQKVRVRNGEPKAVRELWASKDKTFLALDFEWSERNTASCIEWGYAAVRCGHLDTAGAWPPDPEPNYRRGHYIVSEYADKVHNKMKPSFPWAYAFGESQVISKAKLPQIIQAIVSSLISPDSETITNVLVLVTHGTTGDLRRLEEMKIKLPHNLLVLDTMAFERQLYAAGLRGAMQEAFGRPRDQGSSLSLNAMLQSLGVDIHRVLHNAGNAAFMTLLGLQLLFDPDTKVPTPKTPNGMAAMARSSKGSPSVPPAIAFVPPPAVAFPPMGMIPPVTFPGMRLSPDVYADMAGNRASYFPAQRTISDFRDNRPSSASGSPGRLPGRQRVNSTNAVNELGEKMNTMHVKARTTDPGTPPHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7G7</accession>
    <name>A0A4Q9Q7G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_917453</name>
        <name evidence="2" type="ORF">BD311DRAFT_652654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7G7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7G7"/>
    <dbReference type="OMA" id="SPDRTQF"/>
    <dbReference type="OrthoDB" id="2752400at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14935" checksum="9B0C3F2A434F12E1" modified="2019-07-31" version="1">MSSTPFRKSRHSLETFDKLFERAFAPRNTLDLTPLSLTDDVKRPTVLGPSPPSPDRTQFYSPVLSEFPIDSHEDSLDSIWDEVRHAKEVELASSPSKVKSLDGAVTSGSSQSPTLRPASGQQSPGRKRVAKKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9N7</accession>
    <name>A0A4Q9Q9N7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_915867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9N7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9N7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="64167" checksum="438DC8C725EF0728" modified="2019-07-31" version="1">MASNRDSAELLTPPLSAVASDFGKAFPFGDAQGTDASRATLRYERRMGDTELSYFLPSRQAGVNDMSLHLGFRAKESVARRSRVRAVWAILRMRHPLLCARAEMHDYDDVRFVFDAPSSAQDALLSADANLEYRMQTKDELMESFMNGPRTLSNDRLSYLIISEPITSPELMPTPPRTPSPALSDPHEPELEAADDEGHQEAERTHQYELLICAMHFIGDGMALHTFANEFFGLLGGEKSEDELRDVLGDEWRSRWAVAPEECALPSALEDNMPLSPAKFRRVAAKVDFQLSEQRLVGGQVFPRRKHPERHTIIPTVTFPEDRTKAILKKCKAHGVSVSAALFAICNVAWVRTAAEGCNRELPTLMYSALNLRPYFTRKPTSELWNSYWYLAIGYFNVVLPSFLPSASAPEGQEPTFWLRAQQAKAQSTKAAKNPLMASRAHEMSRKRGAQARAWGREDDEREKGTWMPPPPVQAAPVKEPAFPARAKAPSSALIGLSLLGNLDGIYKHATFPNTELHTLTTGSRQRHGGMLLFGYTFKGKLWISLGYDENGFADGVIDRFWKEAMDCVDQFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAG5</accession>
    <name>A0A4Q9QAG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RPEL repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_403275</name>
        <name evidence="6" type="ORF">BD311DRAFT_264855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143412">
        <property type="protein sequence ID" value="TBU29550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAG5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAG5"/>
    <dbReference type="OrthoDB" id="197676at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043451">
        <property type="entry name" value="Myocardin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004018">
        <property type="entry name" value="RPEL_repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793:SF12">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22793">
        <property type="entry name" value="MYOCARDIN-RELATED TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02755">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00707">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51073">
        <property type="entry name" value="RPEL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="RPEL" evidence="4">
        <location>
            <begin position="71"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU29550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11268" checksum="7C59AF4DFBF079FD" modified="2019-07-31" version="1">MSSTQTVAPVEKPKVERKQSIDPQTVQKLEKSLAHRPEKTELVERNILKDDSVAPALQAAKEKLQRSQLEDKLEHALQARPKPEELVKEGILKDTDIPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAN1</accession>
    <name>A0A4Q9QAN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1009989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="97" mass="11329" checksum="71A81FEFDF4E6B74" modified="2019-07-31" version="1" fragment="single">PRRTRCIDVGGFGTLRIHHVHQPSQLDRATPLLMVYHQQKCKSVLQDCMWRLKRRLRRETARAPDLGAKEACPHNTHNTVQDLRRDCMPARYTLGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAP2</accession>
    <name>A0A4Q9QAP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_913230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAP2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAP2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="249"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="498" mass="53983" checksum="B0BA63554F7789A0" modified="2019-07-31" version="1">MAGPAPASLRDLYATPSTAWSFVPPSLSQDSAPGNNSHSPIAGPSSSGQWATRTAPNPLFDLSSSLSGDDSGLDITSLAQELLVAAFYQYATTAIAQPWEVGKTLLQVQWVPRDPRDISPDPAAEVDDEGELSDSSSIENDSYFADPTAEKPPRPPRPADEGGYIIRQSLLEEGTQPEYVIPVGSADGTWAMMKRVGRFRAEGWLALWKGLLTSAVTSGLSAVLQPAIYSLLQSTFSPFSPYSYPGGTPSVLLPVASQVLAGFILSPLELVRTRLIVQSSVPRHRTYSGPIDALRQILAHEGGLRGVYLHPHLLIPTLFDCTLRALIPLTLPGLVASYVGLGSNISPETTPMQWQIAQLLGTAVGCFIILPFETVRRRLQVQVRGTARPLKACVELRPAPYNGMVDAFWHILTEERSDLPLKPVSPKRKRRRSSVKGKETAREVEAEYVEEEHESWLKHSGIGQLFRGLNMRLGAGALVFVLALMSGSDEADAGWAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB05</accession>
    <name>A0A4Q9QB05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">BD310DRAFT_1034482</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB05"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB05"/>
    <dbReference type="OMA" id="KRQQNNM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="233"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="37997" checksum="9050D4D7DB536190" modified="2019-07-31" version="1">MEVDLHPPDDYSHRFFIWHEWIQAHGPLTLENAFDYFTTSMFYDKQSNNQVLRMQTMHTGAPLVNEAEELKRFTGIEFALVYAEAPSLFIIHKRERLSPDEVRPLAVYFILNNRIYQSPDVYNLVSNRLLTSLHSLQKSLDILRAHRPAYTPRTGFAWPIVEPSSGDAAAKKRNMDVENAPETTQETEALSDARSTPAAANDTKRQQNNMLLFNAMRTTAVHARESFQLPAVLSEETVPETPATATVGRSSVTPAPAPVGIATRAPSIAPTPQEPTKGPSGGGKKKKKSKAQGSRPPTVSQFRANIIARYRNGDSSTSWVMIRVFPMHLDHQSRETTICA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB81</accession>
    <name>A0A4Q9QB81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_293352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB81"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19484" checksum="C752C6EA3D4D65C9" modified="2019-07-31" version="1">MFKSHVSSLISVGRFFGPMTAGPPRFLDLSMTEDIAMTEDIACSGVYGHNHLMRTLRSLTRSRQARCLLRQGRATHASPLRHKSSKNDRLDNRQPGDVKSVVTTSNAPSRRFRCGGRRRLLTRTPGTTASYDQTFADSVKCTITKACGHAMPCGRCMRISDRACLSATTPSLRRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB90</accession>
    <name>A0A4Q9QB90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_913745</name>
        <name evidence="12" type="ORF">BD311DRAFT_745638</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB90"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB90"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07843">
        <property type="entry name" value="STKc_CDC2L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045267">
        <property type="entry name" value="CDK11/PITSLRE_STKc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="92"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="384"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU35135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="424" mass="47400" checksum="180F25D1EBC2D501" modified="2019-07-31" version="1">MSDVAGPSTPSRKRSRWDTEEDTTPQVDKPVPKRRTKSKVTTSAGTYTPERTATPPVRSQSVAGRLRPSHSRHVPPRTEHPPFMPSRSVYCYERLNSIEEGSYGVVFRARDKETGDIVALKKLKLDEEKHGFPITALREINSLMVCKHENVVGIREVVVGDTLTQVFIVMDFIEHDLKTLLSVMPSPFLQSEVKTLMLQLLSAVAHCHERWILHRDLKTSNLLMNNRGTIKVADFGLARRYGDPVGVGGLTQLVVTLWYRAPEILLGATTYSTAIDMWSVGCIFAELLLNEPLFQAKGEIEMISMIFKLLGPPTSQTWPDFLNLPLAKTITLPAPQPSQLRQKFPYVTSAGLDLLSRLLAYDPETRISAEEALKHPYFTESPLPKHPDLFGSFPSAAAGEKRRKPDSPSAPARAADYKLLTEFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBF0</accession>
    <name>A0A4Q9QBF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_972513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBF0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBF0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="135"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="361" mass="38213" checksum="879217D981BA9611" modified="2019-07-31" version="1">MSVASRNPFALLDEDASRPASPAPAAAAAAAKQAAPTPAATRGTQKARGGPASRGGKYYQRGGKSAPREKENTEVAEDASGEPRKRGTFLVYRLLQEFFPRRPLLIYSSGIALAEGEGRGRGRGRGRGDRGRGGRGRPFDRHSQTGKTDSEKKVHQGWGGDEGVSELKAEAGAATDAAAETNEWNTPADPSGWADAAPGEAAAAAEDTPAGDKAEREGRKPREPEEEDNTLTLDEYRKKLAGLEIVPKLETRKVDDSAFKDAVVVTKKDEEETAYFVGKSKTAAPKQKAKKEEKVFIEIEARFDRPSRGGRGRGGERGGDRGGDRGGRSRGRGGARGRGGANGQATTALNVDDETAFPSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCV8</accession>
    <name>A0A4Q9QCV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_839745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCV8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCV8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034444">
        <property type="entry name" value="Nuo17.8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42100:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 178 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="18378" checksum="56DAE2AB54CF2DF0" modified="2019-07-31" version="1">MSVARAAGAVLRPTQRAGISLVQHRAASSHAHEDHHDDHHHEEYHDSNVYEPEVFNTPFWRRVVVAGVGIVAFYKFAPEPTEDTLIAKYIKSTMTQPEFWKDTAFKHLVLSAQGSDETLLVADAKPPVVHRYRFPQRFEQFSPHSNPVGIKLTVDDVVVKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEV1</accession>
    <name>A0A4Q9QEV1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_802628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEV1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEV1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="7"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="345" mass="37005" checksum="2FC2221A305E84F3" modified="2019-07-31" version="1">MKAVVITDDHKAVVKDHPVPPVGDDDVLIKTVAVAQNPTDWKHVDFIGTPGSINGCDFSGHVVKVGKNVSTPKVGDHIAGFVHGSAFTDEGAFAEYVKTPANLVWVVPENTLSHEEAATFGCAFWTAVQALYHPTRLGLVEPPARAPKAEWVLVYGGSSAVGQFAIQLLRLSGYKVVTTASPRNFELVRSLGADAVFDYKDPEVVSKIKAATGDSVSVALDTISENGSQTISAESLGPSGGKVVLVLTQDPNATSRKDVQFKETLIYTALGRGFPWPINNHHFDVSHEDTAHMVAFLEKVSQLVKDGGVKSLPVKLWEGGLPAIPDGLQYMREGKVSAQKIVYKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEX4</accession>
    <name>A0A4Q9QEX4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_32749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEX4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="539" mass="58891" checksum="FE3FC827B0FA23A1" modified="2019-07-31" version="1">MGREVASAYRRRKSTVPSVSPFPSRISSATNSSMESLPEAPQNLTPARKHHKLLKDGSEVWSKEVEKIFVEGLRLYWQSPWATYSRGRSRWRNQFLVDHLKKAGIERTKKQVASHIQVLRNMWRGQPEFHLVAGGEELFQENGLLAHTDKDKKPGTGPANASSPSRAEARDSYAGSSSSSSTPEHRTSEFPSDLTASSSYSSLSPSQTSPFLEFGSEDLFATSVSPPSTADVPYGVLPSSPSTAHPITPVSVKLEPLAMDPTLFTLPQPTYSDSGADYTLSLPNRISNLYFWADGMAPLSLDVDRLVGATPSLPSRIFLHFRVSMPPLADLRCPPNLQGVNGAISFVSPWTTIAKCQTKSWGHSRTLMSQDQGLFAQVTTPELQASFNADPSSSQTVYAYLPDSALNRCHWLDTVRTITQQVVVDNEVLAVLVYHIERVADASRQVPTMELIGFQKYPWRGQPPSSAASSHQHLASPLGSPPVTPQSPTFSQALSSSPILPHPSFVPRSVPGTSSVGNLASRMLPYSFPTQATFGFGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFB7</accession>
    <name>A0A4Q9QFB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_775255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFB7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="357" mass="39629" checksum="5AF0ADE0A8700B58" modified="2019-07-31" version="1" fragment="single">MDDNDPISQFFPDQEDVDLYAVLGVKQDANADDIKKAYRKLALKYHPDKHAGANEDAKADASLKFQQLGFAYAVLSDEKRRGRYDLTGKTDEGADFGPGEDGWETYFEQLFEEVTRDKLDAMKKEYQGSAEELQDLKQAYIDTSGSIAEMMTYIPHSTFDDEARFIVAISDMIKKGELPLLPQWESSTKDEKARLVRKKQASKEAKEAEELAKELGVHDEFFGSGKKGARKGKSKGKEKQTDEEDTSALQALILKKRKNAEGLFDNIAAKYAQAESAGKGAKKGKKRSKAAEDEGEGEEEASPKKRSRKDIPPPPDIDDAEFEKVQQRLMESKPKRAADSGAGSKGTTKGRAAKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K2V1</accession>
    <name>A0A4V2K2V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_908776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K2V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20989" checksum="B9AF161439EB650A" modified="2019-07-31" version="1">MTSKAPTRDQLLESAQALCHAFASKSDIDTLPSHFSSTHQISAFEHGLPLLAPFLGRHFHGRAGATSVPAYFQLLQQYLTYDDMSFGTWVVDADAQRVSVKGRAEFTWTEGDGKGQSWDEQFAYILDFDQDAKVTDYQVWADSGAAYLARRGELKQLIEGSESANVKEFSPGQTQASVKADDQSDQTVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K536</accession>
    <name>A0A4V2K536_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_809623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K536"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="435" mass="49206" checksum="BFEA79E1DD321FAE" modified="2019-07-31" version="1">MANPADFGPLPPRFAELKKEIVGSYPDFEARATKAWGEILVELDKATKDIAAQGSANVPEVNFSELGSLTPERKEEIRGKGCLVIRDVVDDQEAREWQAWLRSYVAENPVDGVPEHDKQFFQLYWTKSQVRARSHPNILSATVWLNKLYRIRNGDGAKINDVDLETPLTYADRFRIRKPGVQWDVHPPHVDGGGIERWEDEAFRHCFDDILSGNWREHDPYDLENRVRARSSLYGRPNQATVFRTYQGWLALSETAPNEGTLQVFPNVRLSNAYIILRPFFALKDGANPDSFDPDAWRFDSTTPDFHGIYSYGASFVGPRPNTQTHPHLRLEQTMVPVPKVYPGDMVFWHSDVIHAVEKHHTGKEDSTVMYIPAMPYTAVNAAYIEKQKESFLQGVAPPDFPRNKGEAECVGVGKADDIENPIGKRAMGFAIEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6A1</accession>
    <name>A0A4V2K6A1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145319">
        <property type="protein sequence ID" value="TBU51463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6A1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5910" checksum="010A0A027CAC0121" modified="2019-07-31" version="1">MEVGTREYVLTKLVGALGLICSPCGLLPGAGRHWHTAYYLQSRACLRAGRRPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6T9</accession>
    <name>A0A4V2K6T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_829937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6T9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="28232" checksum="5E0F97D019F61B3A" modified="2019-07-31" version="1">MFPMDDLATSLHPSPSVSSPAQSPALPWEVIEKVIDCCSGDTTTLCAFALTCSQLHPRSLFVLFTNVDLRSMRQLMAFYHAVQAQPRLQPVVQTLSFPRVEEEFSPFPLLSILPGLHQLAFDTFFSLDIDNELPSQSTALCGWQFATSLRDLTIRSTGFRTRTVFLQFLSVFPNVENLTCERLYPFHRVLFRILGSLVLNERKMISWSDEFRRWFHPISENWKLTEDVKYCESRWMTILPSQTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7A0</accession>
    <name>A0A4V2K7A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_934030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7A0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5680" checksum="696429170B017374" modified="2019-07-31" version="1">MAVISSVKCRSRGAAPRLLAMRTSPGRTIPTQLERRLAPHALPPFTVVVRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8A7</accession>
    <name>A0A4V2K8A7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_976768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8A7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="311" mass="33754" checksum="2D53B082B2690807" modified="2019-07-31" version="1">MGHRQGLVAVFDEDKVVRGGACVEMPPFILIAPATRGLSLALARHYLRTTSLPVFATYRPSPPATDRPRIADSVRAHILHPLPSVDPARLHLLPLDLASEDSVAAAADALARALAQLSGSSAEPSFLRVAVFLAGVLHPERQPADLVLDDVLATFRLNVVSHLLAIKHFSRFLPPAARALQTSTSTSAPAGAAEQQRPLVAKWAHVSARVGSISDNRLGGWYSYRASKAALNQVVRTFDLHLQARRLPAVAVGLHPGTVKTDLSRDFWKGVSPEKLFAPEYAAARLAEVVEGLREDQRGRIWDWKGEEVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8T8</accession>
    <name>A0A4V2K8T8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_975239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8T8"/>
    <dbReference type="STRING" id="114155.A0A4V2K8T8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="243"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="554" mass="57681" checksum="83FAFB3302A6C065" modified="2019-07-31" version="1">MASPVLASTPHNNNNNNNNISSSSSSNDNLAQHNPDPSSPPSHPREPHHAQHQQRPPPNPKRSNFDLEPNPFEQSFARPTNDSSLRTQQKSPDSHSRSSQSHSSHDDSRPASKAHDRDDSAKPTLPPIDAISSPSDSSYAWGFSSAGLSNSLRSGPLSPAMLAGPQPNSHNDAPLPSFDPTSFRTGLTPRTGLTPGTGLTPIIGSVFPPPSPGTAAWLNLMSTNGAPSLSNVATITPNTLSAITGALPTSTPHHTTSPTNPSPLSVSHTAGYSGQTRGDNQPTNGSYVTSAAEAAASSTNGLFLLSQAHQELTKREQQQKAAAASAQTNGNGVPAANGKRGTKRKSTYEGSPTAESPELASQSAAAKAPSKRTRSSTTASTSTNGRGKRARSEDSMGEEEEEEEDEASMPTPTSNGKKGGGNQHKKPETEEEKRRNFLERNRQAALKCRQRKKAWLAQLQAKVEYLTNENERLTSALVASREEIARLSALVGAASVGQPVPLPVSGAGASMSVNAGVGVGSGVNGAPVSVNVSLPPPSKSAVAMVGGGGRGYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Y6</accession>
    <name>A0A4V2K9Y6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_911962</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9Y6"/>
    <dbReference type="STRING" id="114155.A0A4V2K9Y6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="16">
        <location>
            <begin position="408"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="354"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="654"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="752"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="656"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="781"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="794"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="827"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="847"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU65738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1008" mass="112341" checksum="ACE49D1381F0A832" modified="2019-07-31" version="1">MASTASSRPANPTSPSYSDDLEFVTAYLTVHALSDASHVYAYLLWIALGSLLLFWSTFHHLHLRGGYLGALWSKWALRRRTWRKKHSLAVAKAKGQPHRQPYSFPSNAQIFTVCLVAICTLVVSFVGPDNLAPGSYLWTLSKYPHATTSGFAKREYTMDQFMQFQPQYTIPKAWWTMGDRTGMIAFALFPLCVLFALKSPPFAILSMSLTVQVFCDKLMLLHKWTALLIYLLTVLHVAFWSVQLFIDHRNGKIAYFYAWQYEKFLFAWIAFGCMTLVFLLSIGPFRKRHYEAFWFLHILFVPLTIVMAALHHPPVWWWCWAALALWVGERTWRFTWWLYTNGFVGAKSAAPSSKLRKAQSQDKDPAPGQPPKVEGGYPYPPTLPSSAPGLDQYPPIVQLPGVGLSLPTDYVPPPGFAHAELLPGRTVRLRIVTPGYLTWAPGQHFLISVVAVTRFTTHPFTTASICDEQNQYDDGRVLVFIIRAKNGWTKDLWDTIAMMHARGQQCLREEHVPRCEMPERGVLLRACVDGPFGSSARASWGEYSSVVIVAGGSGVSYALSILQYICLCMAGRDGRFLGGRKGGFGQPGYKTSRVRFLWLIREFGHIQWCAPTLRRCLDMISPSELQIDIFVTNVKPVPQPNLATTPSRISFAPLPHKQELEPPRPEFARPKSISSLSSDESGEDSDVDLSYYTGFVQDEGELGHEEHVLDLTNFEGDNDAAMPGEAQFNLSIKNEGRSRRFLSRRASTALQAKEQLTQRASQLDFEGPSHSSVQLVRKPHPIPPIDTSLPPPVRVSVGSPGSRASSSSDLGTRRPESQSTDGRHDSYSSQTSLLKTPTSAAPLVGGSMQTQLPPIQTRNLTGAPGRKRFSHLSTLSERTDLLPTPTTSVTPRSTSRLSQWTDTDSFAALVPRGEVESVREQLRLNLDEQEAEDVGIVAEHARPGKPKLERILADEVERAKGAIAVACCGPTSLDAMIRKIVAAQIDPQKVKRGDMRGSIALFSEEFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWX1</accession>
    <name>A0A4V6MWX1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-MPP</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Inactive zinc metalloprotease alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_965393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWX1"/>
    <dbReference type="STRING" id="114155.A0A4V6MWX1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="47"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="202"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00030006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="525" mass="57645" checksum="4457A172ABD02B93" modified="2019-07-31" version="1">MRRAAVHSLRNSASRRVPCHRSIHATKPSSASPDPPVQITTLPNGIRVATENTPGHFSSLGLYVDAGSRYETPATLGVSHFLDRMAFKTTKTRSEEDMAADIDGLGGQILCSSARESIMYQSSHFHEGTPLAMSLIADTVLDPAFLPEEIAAQREAARYELREVSSKPEMILPEVLHHVAYGGQGLGNSLLCPEDRIDQVDAPMMRKFMQTWYRPERMVIAGAGMEHDALVELTAKHFAHLKDADATKPRAEVRTSQQVPANLLQSSQQSSPSFLKSLTRSASSYLYNPQQDPASSVPSQSTYTGGHRFIHDPTTEFNHVYLAYEGVGIHDDDVYTVATMQVLLGGGGSFSAGGPGKGMYSRLYTHILNHFPQIDHCASFHHIYTDSSLFGLFASFIPSSGRQANNPAHILPHLVHQLSLLLYSNIPEQELSRAKNQLKSSLMMALESRAVEVEDLGRQVLVHNRKIPVSEMCDKIDAVDAMTVRRVAARLFGPRSAAKASVVVMGREDVGDYRGVLRKYGLAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MPS5</accession>
    <name>A0A4Q9MPS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_871314</name>
        <name evidence="4" type="ORF">BD311DRAFT_692032</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MPS5"/>
    <dbReference type="STRING" id="114155.A0A4Q9MPS5"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="2">
        <location>
            <begin position="32"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="3">
        <location>
            <begin position="212"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU29764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="39383" checksum="612C715F787477A9" modified="2019-07-31" version="1">MDRPGNIHLLHLQHSEPNPFSRPTTPGHHDLQIGFVGLGAMGYPMARNLAKWRKEHTQAPTPLFVWNRTKAKADDLAKELGPGLIAPVDSLEKIAIECDIVITNLSNDDVVRSVYKQFAKVLEEHKPTRNKIFVESSTIYPALAVELDNLISSIPSTHFIAAPVFGPPTAAAAAQLVIVMSGDYRTKKEVAHLLHPAVGRKVMDLGGNIEKAATFKLIGNALILGSLELLAEVFTLSDKAGIGAASVHQLIKDIMPAPPLISYGDKMLHDKFDGSKGFAIDGGLKDSQHIRRLATELDAPMPALDAAHQHMLTARALYANQVKQGNAHFDVLDWSSLIAGSRVSAGLEPFDSSKQHTKPVPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MRU3</accession>
    <name>A0A4Q9MRU3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobic surface binding protein A-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_878707</name>
        <name evidence="2" type="ORF">BD311DRAFT_718641</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143406">
        <property type="protein sequence ID" value="TBU30305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MRU3"/>
    <dbReference type="STRING" id="114155.A0A4Q9MRU3"/>
    <dbReference type="OMA" id="LSSNHTM"/>
    <dbReference type="OrthoDB" id="3178264at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040683828" description="Hydrophobic surface binding protein A-domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="156" mass="16031" checksum="C346593ADED09D87" modified="2019-07-31" version="1">MARFFATATFLTYVSLVASGLAHAAPARRQLGNLECNIDRAEIIFHVATLSGVVNTLGNNTNLVAANNTVDADVMALQSGTQGAGAAIKQIVIALINGEVADPDLRDQVGGNLTVIQGALGDLSSTDNSTSALLDMALTEFTNSVNAANGVVNNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MT84</accession>
    <name>A0A4Q9MT84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Coatomer subunit epsilon</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_922691</name>
        <name evidence="12" type="ORF">BD311DRAFT_718512</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the COPE family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MT84"/>
    <dbReference type="STRING" id="114155.A0A4Q9MT84"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016478">
        <property type="entry name" value="Coatomer_esu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU30527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU60547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="315" mass="33570" checksum="165F04A5F57AA6FD" modified="2019-07-31" version="1">MESSELYHIKQQFTLGAYKSLVDLTLPDPSSPDYTPTLVYKARAHIALGLPSAAEALVPADTENLALKSVAALARYIGADADDAREVVLEELRDLSVEIEGEDAEASAWEKGVVRVLAGTAFARAGEIEEALETLGAGNDTQNLEAVAYAVQIYLSISRPDLARKEFERAKRWAEDDLLLQLIEASIGLVTGKDGYADAHSFYTEQLANPSLTSTHLLTARGVARLLRGEVGAAKSDLEEAVSQLGGKPDAETLAAQTVAAGVGAAKSADADELFSKLSAEFPDHPLVVDYQQKEALFDELAIKFTVPPLATASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MWQ9</accession>
    <name>A0A4Q9MWQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_914379</name>
        <name evidence="6" type="ORF">BD311DRAFT_688839</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MWQ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MWQ9"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="44"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU31758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22707" checksum="D4DAEF11F0FB3927" modified="2019-07-31" version="1">MAAVQTLPKDVSKLGQEVKLFGKWDTQDIEVKDISLADYIQIRHAVYLPHTAGRYSKKQFKKAQMPVVERLVDSLMMKGRNNGKKLLTVRIVAHAFEIIHLFTDQNPIQILVDAIINTGPREDSTRIGSQGTVRRQAVDVSPLRRVNQAIALLTIGTRESAFRNVKSIAECLADELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MXB0</accession>
    <name>A0A4Q9MXB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP+-dependent D-mannitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_874177</name>
        <name evidence="7" type="ORF">BD311DRAFT_688891</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MXB0"/>
    <dbReference type="STRING" id="114155.A0A4Q9MXB0"/>
    <dbReference type="OMA" id="LLPCFQC"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="176"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37836" checksum="5F80B7314D1F66B4" modified="2019-07-31" version="1">MPSTTRSMQAVWYTKAREFEVRDVPIPQAEDDEVLLKIKACGICGTDSHIHEGEFIAEFPLIPGHEVVGEVVETGKNVTGFSKGDRCVADPTTVCGSCFYCRRGRPLLCENYIGIGCSAPGGFAEYISLKANKLFKIYNLSDEEATLVEPAACAVHGMDQLDAGVGVDALIIGAGPTGLILAQMLKLNGAHRVVVAANKGVKMDLAKELDAGTEYIELDRENPQAQWKRLKQDNPYGFDVVVEATGMERVAQDSINYVRRGGTLMIYGVYSNDALVHWPPSKIFVDEIRIIGSFAQMHCFPRAVAYLDSGRIKVKGMVTDVFKVADYAKALDKLRSRTAVKIAIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9N7</accession>
    <name>A0A4Q9N9N7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_383864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9N7"/>
    <dbReference type="STRING" id="114155.A0A4Q9N9N7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="427" mass="46651" checksum="A8B2E05DDC79F619" modified="2019-07-31" version="1">MEMPPAIRKQDLRDRGDSTITSSLHHPVPVPHPPSRPPSRPPYSMDTLPLETLQRVFQLACTDGGHTGCALSLTSKAVRAAARVSRFHSVGLVAHPDISHPFLTLYERERVPAVGEPTARIAHLSIAFPALADASCRSPTASHRPQDDLGPWRPPFPRQYLEDVRRLFHLIAPDLRSLVLCRASEGKCEPSELALPIFSTSFPMLHDVSLFGLASPRPLLALHDDNLTPIPLFPSAKRLELAPGPLSKGVSLDELAWHAPCIAELRLSNLQPSPSTIDSLAGLAKVVSPSSHPDSTWDALRTVTLRPCAPPPGVHDGWCGDAGPKEQYTGLWRALQRVRWSADRTPAQSAAGYARAGTQVVLPEGRDYTDAELQSLARRRLVNGWEDNEAVGREAGRNCDGESHVAPRPRHTPVVSGWQRTTILHSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDA6</accession>
    <name>A0A4Q9NDA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1005068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145308">
        <property type="protein sequence ID" value="TBU51555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDA6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="263" mass="29544" checksum="95B7F6A8A013F2A9" modified="2019-07-31" version="1">MNRRYIGSLEPYLGDYLIVWDSACGSDCREDNFPAPHLGDGTISINYAKPSAWVKEQEPPVPSARPLLYTPPKENAVITVRDPYLGLSHGRTSTTVKPAAFSVRRRSLPLSDTSSGWSGDSDTLVKYALKATSRENHWPNGSCFWRFDWKRRAPTLGYRTEGMDMTTDEGHALSFTDAVDDHGFPFAIIELRGTEDVGCIVVLAKKQTSTHARKYLSLTEKMRLGMHDVRCRGKGDFEDNLRESLRRASKEYVPRKPFGPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMF7</accession>
    <name>A0A4Q9NMF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_831249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR48 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145232">
        <property type="protein sequence ID" value="TBU52914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMF7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NMF7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17041">
        <property type="entry name" value="Ubl_WDR48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051246">
        <property type="entry name" value="WDR48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021772">
        <property type="entry name" value="WDR48/Bun107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19862:SF14">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11816">
        <property type="entry name" value="DUF3337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="400"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="783"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="881"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="886"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="921"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="963"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1036"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1159"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1243" mass="134650" checksum="A05456E643FB9C56" modified="2019-07-31" version="1">MAIAWDLGVPMKRRAQRYGYTGRSLRRWEVMTNWADDIIEEEAEEADDYRSDGDVLGEVTGKTRRRIPADDTIPYEEQWETDMDAYQALKAHPPTSHFRQAVQMHSDWINDMILCNYNQTLVTASSDGTIKAWSPHAHGQSSSSLHEPAVLGTHSDYVRCLAYCREQQWFASGSFDRTIKLWDLASASASGSGAHRTDPLITLSPPEGAGPKASVYALTTDPYGSVIASGSPERVIRMWDPRSGKRIAKLVGHTDNIRAILISEDAKYLLTGSADASIKLWSLSSQRCLHTFTHHTESVWSLSSTHPSLEIFYSGDRSGLVCKVDVEGCTDVAEGECLVLCQDSGGDRPGTSGAGSEGINKIVAMDDNLLWTASGSSSVRRWRVPARRVVRGSVWSAEGAVDSPISSLPPLDHRRRDSLDFTFPPSTFGSGSAAGGRTKSKSPVRSPPLSQETSRSSSPLAPRSLSASNHKRASFTPSMNSANAMAGAESHVDLDSEREGEETWYGIPFESLVRLTSPNNDAGFGLGLGPSLSMMKGHDPEIATLYSAASVLSVPRMVRSPVQQIFGSNSQPVRSVSPFRGDTVRSQTRLVEEVQTPRPRAAFELREVAADAIPLRLEADEVIHGEHGLVRCVMLNDRVHALTVDTAGEVALWDIVRGVCLGRYPCEDVAAVSFCGSDKSVAASAREGRGGRYEGETRSPREALETVRERIEGEAVVPSWAALDTKTGVLTVHMNEKCFEAEIYADEAGYGHERQFNEEARLNIGKWVLRNLFHGFIREEQRQAARRAREHGSHDPSHHRLQRGSAPTHIDLNSTNPDVRSRASSDVSVRSASSAALGLRSATIILSPNMLPAVSPAVSVAPRSSPLMTPLIPLHGGIRDSGLPTIPQSPNPTDITPISHGPRDTQRSDGTATPAALPPSTYGTVTNNDYFSQRGSSRRPSVSTPGGPVTPDDFSGWGGKSVGSDTAPLQTPSTPTVGSLMGRINKAFSKNKRQASETTGTTSQGSATTNTQVETVAGDPSPPVKTPAQALLAGPITPPPSSEAPPLPIPQNTSIVISEEAPSGWLTLYRGQVSSTGVDARMLEEVMPLWLLECLLQNKTPSVPVTKVSFVLLPFKELGVEPLPELLNTQQSKLTASRFLRVRKLTVHVQDKLDKIANGGTSPVSASATPRSSFDRRSLASGRARDHDSRPRAEEIYEILCNGIVLPLDMTLAAVRQYVWRQSAELVMHYRRKAPVHAGAHGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMV3</accession>
    <name>A0A4Q9NMV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_194593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMV3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20922" checksum="AB34B3A528D2D326" modified="2019-07-31" version="1">MVIVSRSGSVVYLKSELFRCVRQSRACRGGKRPDICGTSCPPSSSESMQDHRLARRPIAISFVSLNKSVVYAKDIHCAGGKCRNKEERGETFCCFNVAEVMMPLQWDTLCGSMPPLCIYICLLRLLEILVTAKVFAGLECEIWNMSLAGCSSHSDSSMQGRAVAVFVELARMATPWPSKRKASSRTIEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNX8</accession>
    <name>A0A4Q9NNX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">PIN domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_870816</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNX8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNX8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000057">
        <property type="entry name" value="RAD2p Single-stranded DNA endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="118"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="348"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="400"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="738"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1093"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="799"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="601"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="752"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1164"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1232"/>
            <end position="1243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU62709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1243" mass="137063" checksum="F5D1303A560BE35D" modified="2019-07-31" version="1">MGVKSLWQLLDPVGRPVLLETMEGKSMAIDSSIWIYQFQATMRDKEGRGLVNAHVLGFLRRICKLLFYGIKPVFVFDGGAPALKMATIAERKKKKSGAAASHARVAERLLAAQLRREALDNATGRGSKGKGRTPSGPARIDENTVYLEDFTSSGPGVPQTPARPVAPEGAQSTSPSSSKKSRWRDHDPYKLPDVNMDEVVAKATATAVPDPRLATEDELRIFIEEMRPEDFDVTSPAFRELPTEVQYEIIGDLRLKSRQTSYKRLQSMLRKARTPLDFSKEQIKNLKQRNALTQQLLVTTDSVGKAHITIPIRIASERNKEYVLVKNEGEAGGWVLGIRDEGTAMKPIEIDPAPAPAQVDSDEDEDMEDVPIAPDASASEPYDPDLREYRRQQALAALADRYSPRKLTTPTTRVTRKRNARPLFEPEDDELVQLDEGTNDVEDPELVSAIQESIELEEEASLRRAIEESRRTASGTVKNGESSGSRPAPEQRRSQQFHSVGDDSDDEDLYASPTRLETALSIAGAGPRRPPASKSSGPTPFPSATTFGMPSLLLPQDPHTLPSKPSTSTYTDSEDDMEEVPVTTPSPQPEVVPALTRPDLPEPIPMPPYQLSPVQKEPVRQDIPAQSTPIAVESESDDDMEQVEVPVPSSARSSPLRLSTDASLANHVVHVALSPQEEVPQVSQPILPVTTRAPADNMVHQSPEVVPIDTPVASASSHSGETASVPLPTFTSVDKVVLPSNSDAEPGETRWSRSPSPAADASAHKEVPEEGWDAAQEMDPYAEEDEYTRFLSQVKGKDVDTIRREIDEEIRELNKQKKNAMRDSEDITQQMISQIMIMLRLFGMPYITAPMEAEAQCAALLSLGLVDGIITDDSDVFLFGGGRVLKNMFNQSKTVECFLTTDLERELGLDRDKLVRLAYLLGSDYTEGLPGVGPVVAMELLSEFPGHDGLHKFKQWWMKVQSGRDKAEESASSFRKRFKKKFKDLYLLPEWPNPAVRDAYYHPTVDESTEPFKWGFPDLDALRGFFNSELGWDQTKVDDLLLPIIRKMNKRSQNASTNAQGNLSGFFDIPLGANAAPRKRQAYTSKRLQQVVSDFRKQQARQRNSATPKLADDGDESEFQPSAEAARPAKKRKKSDEATSKGRGKGKGKGAEIENGVAPPARGGRGRGRGRGGKRTSKKRERPPSESDEDEFVAGDQPPVADLPVPSREELGLRPRPKPRPIVKPPVAVADNLEEQDEGGPDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPB4</accession>
    <name>A0A4Q9NPB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_465646</name>
        <name evidence="6" type="ORF">BD311DRAFT_516384</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPB4"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="HMG box" evidence="5">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="227"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="42"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="449" mass="48789" checksum="FD5FD70800D40ED5" modified="2019-07-31" version="1">MQPQPNRLNTASPFVPPPPSASPGAVSVPPSDSEWSTASDWSLNASNPSSRAPSPYQLARLTPQLPPTVTEEHIRTLINVCNAIGGRTTPIASTSQCPPPAPLDPSTSRPATPNTKTKKVRRPANAFMLYRSWLLKSGQIPKNVEKRQQNISRVAGECWNLLSMEEKGEWHDKAEIVKIEHALLHPEYKFTPERKSSRRKAAADPDAPVPEGEDLIRFIREKYVGIKGDAKAPPRPRKSKSRRKAKAEPEPVPALSYTPASSPASTRMPPTPGSSVPASPSAPSVPAMLADYQMPVLPNIQPLPHELNHEMLGKFVASIAQQNLRDQDMTPRASTFGDITLPSVPKFAFPDTLSSPAQAPLASSGPLATGSTSLSFEHVKDEAGSSSMPPMSDAEAPVNWEQLQYYGDALSQQSVDALMAEDPSMYFSFGDFHGQFEIEAPVFPDMKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPK1</accession>
    <name>A0A4Q9NPK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_909824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145232">
        <property type="protein sequence ID" value="TBU52919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPK1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11082" checksum="6AFABE3E182E7C31" modified="2019-07-31" version="1">MHSSALMKLSMVVAVVVNIASVVALPEAMSLGARQGPIECLAEPCDPVEGCCGNAVCTPHAYLGLPGVCTPATCDVICSTTADCCTDVYGSTFTCQLLDGQSVGVCIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQU2</accession>
    <name>A0A4Q9NQU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_969813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQU2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="439" mass="46400" checksum="936EE51F47568E3F" modified="2019-07-31" version="1">MDRAQFVAPHILQHHLSQKRVDSSILLETRVTSVSPLASSETPQHIFPPVEHLYTTPQAIQDLLRCRPGASVGARRRLLLALLSTGGCGSCPVMAKSPVRRRQVQDPGMISTFSPFSPIIPCFLPLLPCPTVISQTSASMQTPVSSSTNSSSPKITSSAVHTSDPSFSLSSATGTQTSTSSASSPSATPDFAWMNFPASVELCSSPTFAWSYSGPRESLAFLVTANVSHSIITISSGVDSTLQFFTWHSVNISTGWYTLEASGDSVQAVSPEFTITGRDTACLITSASLFSSSTGTTSTPGTASAYIAALPSSPMTTTTLAAVSRRVSTAAIAGGAAAGVAVLIAATIGMCYLWRRAPRQRRAAVTRYNVWVERNRREVWDSLPPGTHSSGYIPAEKGDAAGLSLPRLEPNRRPPSALTDARGSRSSLLSDTMSMASLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUW4</accession>
    <name>A0A4Q9NUW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_932236</name>
        <name evidence="1" type="ORF">BD311DRAFT_761355</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143438">
        <property type="protein sequence ID" value="TBU26968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUW4"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU26968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="68" mass="7522" checksum="EADCDDF1BD18AA24" modified="2019-07-31" version="1">MLSSMYSIGCCSGALSCMAVVSRTGQARHRFSLNPERPSNVLLLMSHPNDECTFFASTRIMPQESLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUX3</accession>
    <name>A0A4Q9NUX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_820232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUX3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="23029" checksum="FA7BA3553649CCC3" modified="2019-07-31" version="1">MVIFTLAAIFMPDPPPPLDDDRCGYAFCEVCTAEAPYACSACKTTRYCSSRCQNAGWRNHQRECKIHQKLHEMDVRIAMTRPKRPPEGICTGCNAQVGEGRRLAMCRECGYQACGSCESHHSRGTCYCPNANFGKRYCQMEPRWYHSNGRGRSYAGDRHPDPDALGGRPYPSDVYEPAPRACDSCGTVTRVFKKEYRDPWVWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXQ5</accession>
    <name>A0A4Q9NXQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_960291</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXQ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXQ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU56337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="412" mass="43744" checksum="FAB27914C1F2E6C5" modified="2019-07-31" version="1">MLVTLASRTLSLYVLISVVLAVSVPPALESRASGACTLEASGSDDAPAILAAAADTSCPTVTIPSGTTLSIQSKLNMTGLSNKHIDLQGTIKFSDDLDYWKDNAFTFSFQDQAAFWLLGGTNIVLDGGGTLDGSGQAWYDAFAKDDSTVRPILLTLYQATDITVQNIKMINGPEWINFVNEGKNVVFRNITITAVSTSSNDAKNTDGWDIFRSDNVTIADSNITNGDDCVSFKPNSTNILVSNLSCNGSHGISVGSLGQYAGEYDIVENVLATNIRMSNAQNGARIKAWAGKDVGSGIVKNITFEGFVESNVDNPVIIDQCYETSSSDCTKYPSNTYIEDIWFTNISGTSSGKEKAVVASLSCSPDGRCSDINVNGITVTPPSKYGEPSFQCQNVDVSGDDASLFGTCKTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZ30</accession>
    <name>A0A4Q9NZ30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_663928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZ30"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="632" mass="69214" checksum="56D9EA3E04EF0D1F" modified="2019-07-31" version="1">MLGRRIVEPCPAIEDTEDSQWLPEATTSLTVRRVKSAGLRIVTESEALWPDVSLGHVNTLRPPSVNRQSYLSMKTPDTSHTFGFPNPTMASPEHPYAVTSSPSASPATGILHAPRLSRYSQVESTLRSAAKVSYVEVPPQELQIRVLEKATAILSEQARDAQACASKLRARLAEKGSKSLTREELEALQREYWMEEHRSVARKIQCEETKGLLTKLSSPISEVPPPLVVASPPLTRQEANLARFLQLSPTRIDLPRSRSTLTSPTLTRRKTISHARPMRLRPSALDLALLSPIQSHRRRSRSFDATHSRRNSGSTDATFVSEHSSEQSTVALPPAPVKSPSYPVLSELDGVIRIAKMASRRPLETLLAEAGDIAIPEYAVDLIEDFAASPISVDTMLSPVVFSRSPSTLFSPMSPRSQPPPQLEMPSLSALEDRDPRRSLSMPDFSHFAMEDEEPPKFNSPVRAPSRPSSPPSLPRPSSRTGNIIDRLRSPAAGNGTPVVPRRPATANACLRSTATQSLHASSIRFGSLRLSSPSLMTVPESDVDPLQRPQSSMSGFGYASPEAVLERAENGREVKPGRGRFSISSMRRRRLNSTPSDVSTGESRSTKEKAEGAKGVLRGLRRKLSMLGSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZV0</accession>
    <name>A0A4Q9NZV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_929145</name>
        <name evidence="3" type="ORF">BD311DRAFT_747512</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU57483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZV0"/>
    <dbReference type="OMA" id="ACPNNNY"/>
    <dbReference type="OrthoDB" id="2730829at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="174"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU34307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="38431" checksum="B992835542A4A66A" modified="2019-07-31" version="1">MSSSTLNEPSVPKDTLLLVGPVFLGAVTSWLIFGISIVQLYIYHISFPNDRKGIQFLVYWVFILDIFLTVIAGAMGWHVLCAGWGRQTNLIQPGWTFSAIGAGDGIIATTVQLFYAWRIWVLKKWRVIPGLIIVISLAQLGSTLSIAAGIANLQDISGLLPYFPRTTIWLGGGALADIFIAISMVYVLTTAKKNSHALKSSDRAINRLIRLSVETGIITAASAIIELGFFLGPTTKNTNLHLFFALILGKIYSNTMFTSLNSRLGTQQATTSRAPTDVTSVSITGTHNFRGGSTSVRTGPAPPVVHIASHTEVFADDVYSSDRDDKQTLNDDLEMMERKPRSDIHLQSFSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P353</accession>
    <name>A0A4Q9P353_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_814715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P353"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013950">
        <property type="entry name" value="Mis14/Nsl1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31749:SF3">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN NSL1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08641">
        <property type="entry name" value="Mis14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="24187" checksum="A8D89D9ECB6485EC" modified="2019-07-31" version="1">MAVDSQREEIPRISVETLDDWRRIKRNYTIAALTALDEQLSGNDSAEDRQVLLAHLHRFIDKTFEMARRNVRVNGQNLEDLNEDEVDTEPFDEGFDRHIWSLSDQSLRWDLQIARERRTRPEEIEKQMRDLLAAQKELDAEEAAALEDVQDEETMVQDDIPPDAYARIDEVASQTFALVEELKQAVPVQLERSERVKTVAEEIKSLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5T1</accession>
    <name>A0A4Q9P5T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_976607</name>
        <name evidence="2" type="ORF">BD311DRAFT_862459</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5T1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597621" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU32485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5235" checksum="68ACF355A1390A5C" modified="2019-07-31" version="1">MRIVHAALLAIATVLVVPASVLAVPAASPEPTGTDGKILNHSVHVKVNQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9N3</accession>
    <name>A0A4Q9P9N3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_953318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145339">
        <property type="protein sequence ID" value="TBU51324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9N3"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9N3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23847" checksum="9F9C4E0E13A944A2" modified="2019-07-31" version="1">MYYLASSTTTAATDGHKPNHSYEPPKTLVSFSALNNDVLHEIASHLSGRDALNFALTCRRIHDFAIHRVSCTLFCQTAADLRRARLYHLQGLPRRAIFLRSLSIADSVFIDRPWQDDLNWADPKTTYEYSLATLVGDILEAAQNLNHLRLEHFAHLVRHEPRIRDAVAAMTHLAGLELSEVDVESLDIFRDLRSDLHYLQISTDKWSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA13</accession>
    <name>A0A4Q9PA13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_834173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145312">
        <property type="protein sequence ID" value="TBU51520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA13"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="128"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="45439" checksum="9471B5549CB5E51C" modified="2019-07-31" version="1">MHNKSSLVPTARDTQCFETLRAAACGNFEDEAGRQIAFTEVLIEGGILPEGVRPGFVISTDYHDDGDLRAMCLGHEVFYYIQVIKNEVCATKSEPYFETICCWLEQIRYIMNKDDRAGKVRDLDKVNFPVVLVMHFGPFLVVAAAVYGSEPSAEVVGCIPLHVHDTNLAELEAGDRLFAALRVAVDSLRERYPDIANSRRSLANFPFREFDIDDHGVRHEFTYLTAIDKKRVFRVETLDTETSRLIVNFSRRYSKAAPRAAHALGLAPALHAVNKVNDWYMIVMEDMPASYTTMWDLKRESSSAAMSLEDARDTIKTKLAELHRRGFVHGDVGDINVLVRDKSTAAIARDVLLVDWDWAGVKAEARYPRDVNQEIARPKGATSGELITEEHDMWMAGRLIQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA66</accession>
    <name>A0A4Q9PA66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_941969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145305">
        <property type="protein sequence ID" value="TBU51580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA66"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9021" checksum="51FC77E2535962AB" modified="2019-07-31" version="1">MKSSSSFHPRVPKRRDPQQRQLAVDGLECLRRCHQWSCDTVLFPNGASDCRFRRSAPPIRPQGPIAGKRCSAADGTVQTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB21</accession>
    <name>A0A4Q9PB21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145370">
        <property type="protein sequence ID" value="TBU51175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB21"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="408" mass="46974" checksum="9E70DA20A532419E" modified="2019-07-31" version="1">MDTKITITIGDLPAELFHKVLEQLGCEDRETLAACSLVCRRWFDISRQHLFSDIHVPRDCDETFEDLATFVELHETTAGYVRTLNLEARLFHIPPVISLMPSLPLDLLFRILRALPNLTILRMRQIKIAPSDPSDVSRLHRFNLEHMEYQKCLSEIGHTFELLSWFHIDHFDFDPLFSDSTETEIKAGDYALDVRSLCVSPWTTDPRLTFQVLQQVVPRYMLKSFRYPSLTILSTPIPVVDFLREVGQNIIDLNLCPSGQDDYLVLPQLPSLKVFRYHLEISLFCRPADLSLQRAVFASFKESWLPHLPMDLEQLIMYLTYPEVEDGIVPAANTSALWGLESALARFPRLKKLSLIFPELPCDMKTAISAAAVCFPTHYNRGVLEVDVRDFALECRDFDIYGYLRECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB67</accession>
    <name>A0A4Q9PB67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Caffeine-induced death protein 2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_807392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB67"/>
    <dbReference type="STRING" id="114155.A0A4Q9PB67"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="185" mass="21364" checksum="6F129B14470D1ACC" modified="2019-07-31" version="1">MSSKQPQLGSLAIQAPSLTPKTVHVSPSTCHDVSVFKELMSQYRKLDDTINLRLNRATAQYRDRERRGLAGKGDVEEQACAQVWRELIANWSRRRELVDYCVGVVDQAMEEKQRSIQDAGDDASAQRKARGALYAEEVKRNQIRNELFVENIVRKRAFDAFRSRCRYFEPPQTDAEARKWWESSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCC0</accession>
    <name>A0A4Q9PCC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_940232</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCC0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF2">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="172"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="162"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="392"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU52444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="49112" checksum="4E80EFC5F14D1BEC" modified="2019-07-31" version="1">MSSGNTQLYAPRPQGPPTHFYPPPNENALQVPSLHPSPSPSRPSDDYSANGYRKEGRIGVDYRQVTRTPSPTPSEAEALVNKTQSFNLKKFLDPSYLKNPRNLISLIVTILILALVIVFIVEQNNIVKALRPVAQWMRKTPGGWLIPIGIMIILSFPPLFGHEIVALLCGDVWGIGIGFAIVAAGTLLGELVTYYTFRYCCKSRGEKAEQKNLRFGLLSEVIREGGFKMAIIVRYSAIPGHLTTAIFATCGMGVLTFLVAAVLSLPKQFATVYLGTGTVDSNGDVQPSHTQKIVKIVLIVITTIVTMGAMRYVNGQIDNVKQEVIYKRRKARQAKLAGASASSFSFKPARDDDPEDVTPLVPRAGGNNGYARVSMDNVDVHVPTPAYTNAGYAQQQQQPIPTFAPPRSPPPNVYGTETRYDDAYGGRDALSTGGLRTPAGSSPGPASSTRLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCD7</accession>
    <name>A0A4Q9PCD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_231228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCD7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13565" checksum="2C158C1828893957" modified="2019-07-31" version="1">MQAATLIANVSSIGTCPQDLLAVAWLLNLRSDGIPFDPVFHSRLFVDLESAAFCVEETKLTEKLKSHLTSISMSCRVIATISERSCIARMGRSQIIIPQISYAICLIWPAFGTRSRHPMSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCQ9</accession>
    <name>A0A4Q9PCQ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_831921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145245">
        <property type="protein sequence ID" value="TBU52569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCQ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="66" mass="7388" checksum="8277F7EEFE988C87" modified="2019-07-31" version="1" fragment="single">FLGGGRSCIGFTFSQLEMKVVLSELLGNFVFEPSDRPVFWNISGVTYPSTSIGSTKSELWLNVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCY1</accession>
    <name>A0A4Q9PCY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145249">
        <property type="protein sequence ID" value="TBU52488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCY1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="471" mass="52992" checksum="B84858B742BD53F9" modified="2019-07-31" version="1">MAGLRNYSHTFGELNAMPTFSQGDGDGDGVMGGGVRGGGMGDPLGLGNMSGFEPSSFMLGEAATYNFQSTYPGATAMHAAQQQQAIVASAVEIVVRELQPHLARMRGEISERLMNALTEKMGNLFDEFRQEMSKVVEEVRSEKKGEDDSDDERDRPLTQMVHFYTRQLLGCATKTEKGPTGRPYYKLPPPLADGEEPRLAADGTQLWNPNWFADVDVGINAEFVHAVVELVLENGPKVFHLDTDQVPRTRIEEYAKTYFRTLRSQYQRRATAEGQKKIGDKSLREKVRQQKKRKAARMRAAIPAFRKYYHSDKTEGIDALVLTEWQSSEHDDFGAASEAEWKKCRDDAMVGQSAVELNRIYAVLRKFADELHSGAQGVRYGRFRGPVVNYNLDVPYIKRVRADKKGMKKERMRPTQECMSESWAKHTDNMHLLEGASLAPESMTIFGLTILDDDLPKDDCGWIADVEDWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDQ4</accession>
    <name>A0A4Q9PDQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_185921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145230">
        <property type="protein sequence ID" value="TBU52959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDQ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="7001" checksum="40A1746327F335DB" modified="2019-07-31" version="1">MMISYIVSRSSFKEKGLSIVPVVLRQSYVQPSERSSPYPQVRFPQNVFSVSQLSLQPHVNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF26</accession>
    <name>A0A4Q9PF26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_833776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145294">
        <property type="protein sequence ID" value="TBU51672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF26"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18108" checksum="7318A8AABFC4751C" modified="2019-07-31" version="1">MQSVSKSFVESVTKLRPKLEAEGLLRHQNAAPLRVLLAALKARKARTSFKLVKGRKGNTALESAFSLATEATRKAAPDTVNVGVDPVWKLSGANLVVMSQGLAYRAIKSAQAAKLKPRAQTNVNMTNIIDDVESAFGVRVSTADVWRSIRSKHIDKLGAVKTKIRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFD0</accession>
    <name>A0A4Q9PFD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_937901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFD0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="78" mass="9022" checksum="7E38B8415CF6CCBB" modified="2019-07-31" version="1">MSLSRASRASRRVKLWLHCHALEGCFLFLLCVPTRFGWKRPKRDTKRDSRSFDRDGLHHSLPQDRPTGFQIASLSGVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFH5</accession>
    <name>A0A4Q9PFH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_952422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFH5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14372" checksum="5A2F294B89DDB6E6" modified="2019-07-31" version="1">MKVCIDESCTDMILKLLDGHLSFDSTVCQSIAAMKAKVPREFSGDGPYPMYAFPLPGVQKSLDLPILLHNAFYLPPPGVPDSVRYDIFPNFAAPAMDLVMEPTLPPHLMPLCPATPSMPPVPQYHSYWIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH91</accession>
    <name>A0A4Q9PH91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavin-binding monooxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145264">
        <property type="protein sequence ID" value="TBU52146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="582" mass="65653" checksum="D165B5CD5AA14F46" modified="2019-07-31" version="1">MFDDESLHVPAQQGPEAAQQDGRFVLGSFSIDEYRPIKVIVIGAGFSGILAGIRFPQKIPNVDLVIYEKSAGVGGTWYNNRYPGVACDIPAHCYQFSFEDKRDWSAFYPPGSEIQEHLQDVVDRYKLMRYIKLKHEVVHAQYDAPTGKWHLRIRPTGAGGESGGALNEFEDVADVLVTAFGAITRWKMPDIPGIDIFKGELHHTAGYKPSGKTWEDDLDRWGNMRVGVIGSGSTAIQMVSALAPHVKELSNYVRGQTWLSPRSVVGQIAQLLGREQAVEEDGLMLSAEEISRLQSDDEFFRTVRHTLEDTMNSMHAYTQLGSKMSNDFQALIRKNMQEKLATKPEIAEKLIPGFPVSCRRLTPGPGYLEALCADHVDFISSPIKRFTATGIETEDGKHKDLDLIFCATGYDTSWQLPFKIIGRNGVHLNEKWKPYPKTYLSVAADGFPNMFMSLGPNSATAKIQRERLKSMEAKPKAVKDFDRYIESYFPQTVFSANCRSWYKLGKAEGRVVGLWPGSNVHAMRALQHPRWEDYEYEYADSEDNSLYWLGDGQTSAEKNQQGDRAWYLREEFIDRPPVPQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHY5</accession>
    <name>A0A4Q9PHY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_782608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145209">
        <property type="protein sequence ID" value="TBU53637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHY5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6977" checksum="76D9BFD3A48F3A6A" modified="2019-07-31" version="1" fragment="single">PKTIQAADNHTFRGVGRGDMFITVPNGKTTTRILLRDVLHAPAMGVTLVSVSRITKAGSSVSFHSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI12</accession>
    <name>A0A4Q9PI12_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI12"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14978" checksum="ED7F3895B0239C52" modified="2019-07-31" version="1">MLSWSRPLRTPHPRGWPTSRQPRSLLTSLESKRLASNRRPGEVRLSARIHPLLRTRAKMRKHELQQGVLPAWTSTLRATSSTSHGELRAFSRPWKLTASATVQNASFEASTPKSTLADRESGGHWRAHGGLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ45</accession>
    <name>A0A4Q9PJ45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Krr1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_936688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ45"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJ45"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="525"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="280"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="627"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="713" mass="81540" checksum="3706AFF2A8AAB0BC" modified="2019-07-31" version="1" fragment="single">MFSDDSDVEDVKLTFTINEHYAKAYEYRKEREELARLKEKYGSDVDEDDDEEDSEDLESEDEDGEELTPAMDAAILRTLARIKRKDPSIYETSKDVFEEEKQRTGELQIDKRAKDRSKPLTIRQHALASAIQDATGSRSLSPEPLTHVEEQKKLREETIAAFHAAADGLDDEDDLLVPREKTKDDIEREEEEYRAFLEREVGQDLAKIITVDDDVEQADGVDVKEEEADEPKKKRRKQEKTKAVSGKGKQDQDQEFLVNYILNRGWIDKSARRLPTYKEITGKGKGRINLDSEDGASGSEAGTNGSMEEDEFDDIADAFESSYNFRFEEPGAAEIARHPRNLPSLVRRQDTSRKEAREKRKARKEEELLKKKEEVKRLKALKMKELRAKLERIGAEGGKRLEESRALQELDLEADWDPEAHDRQMRELYANDANEFGPDDVIDEEKPTWDDDIDITDIVPHGLDTDDEGAGPSEKKKKKKKKRGGDEDAMDADGVDVDEMDADVERPKPAFDDEDWDGTEEMRKRKLEEYMDEVYGLDFNDMVGGMPTRFHYTKTEPQHFGLTPAEILMATDAELNSYMGIKKYAPYRKEGKGRNWDAQRGARLRELKEKLKERGTGGVQAVEQAMKKAKKRMGKKERMREKAVATAAASEGGTGEDEDVKTNDQVPKERKREREATEVDSQEDAWDQRNDAAEASTKRKRQRHRKAAAKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMI6</accession>
    <name>A0A4Q9PMI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_950819</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMI6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9199" checksum="7FF509E9DA7793D1" modified="2019-07-31" version="1">MAILQPVKYASYLTNPAPTTAQRFKSCSLPDTSRSRPNIIHPGAPRWRMPADQLEAADIDGTLDDRLRAAFRPSPSDSHPAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMM0</accession>
    <name>A0A4Q9PMM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-related domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_825698</name>
        <name evidence="2" type="ORF">BD311DRAFT_670478</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143468">
        <property type="protein sequence ID" value="TBU25014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMM0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMM0"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9626" checksum="6CD657975E305CFA" modified="2019-07-31" version="1" fragment="single">SGRTLAIWAHTCDTVGYVKDRLFEQLGIPVQYQRMVYAGKELVNDRTLSDYNVRSESTLHCALRPVPIVLNLPSATCLPFSLTSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMQ4</accession>
    <name>A0A4Q9PMQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_682688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="5"/>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMQ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="14397" checksum="A2E0EABA491C6660" modified="2019-07-31" version="1">MRISAYRTLGRLFVGEVVPQKKHKLVTTGMYAYVRHPSYKGWGMLMLGHSVALTTPRSFLAAIDVWSSTLGTIVALMLVRLWMMFIPLLCVRTKREDEMLRQAFGTEWEEWAKRTPYGLVPYVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNQ7</accession>
    <name>A0A4Q9PNQ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_932799</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNQ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="499"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="322"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="406"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="58732" checksum="11B8547F3B736F88" modified="2019-07-31" version="1">MVSLGYAGADSQARRALVSLVFAELWWLVQFVAVIALLAVSARSKSPTKPGLTEWSACDRPLGAWNALWLAKVVMSASLSYWAWRRTQAHRMRTQRGPARRDSSDSELATQRVLNGRPHYGANAGQGTGPRRAQTGLSYEGTSGANGASTPEPPKSPAHSRLTLLTSFLTLAWFLTAHVLEYTSVNSCRLSSPHLWWLTFALLCTLYLMVLEIFLLGLLVFVLGPVLYIMYNILLLCLGRHPLQNPHYIKPDITKLPKAVVDQIPLVLYIPPPPGEPADSTPSVPVSVTVPAPAHGYPPKSPAPSAGSGAAAAPKRRFMFLRRKDAKGKKKPSRAGSASAKSSPEKEKAEKDVEGAAEDEDDEDVPWDEMWEKGEYPFVRLEGNRAVCAICLMDFEEPRRVRGAKGLRSDAGTRAADANANANAESGSSEPHRRGPGAGASAGQEGKSEGKDEEGGGEATQEIQVEAVTEEERDALKLGDGAGGEGEEGDGEGPQPLRLLSCGHVFHKTCLDPWLTDVSGRCPICQRPVEVPQPTKKGKGRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNY9</accession>
    <name>A0A4Q9PNY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_644888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU56011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNY9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12529" checksum="80B14F066004F35F" modified="2019-07-31" version="1">MALPSRGQRLFPIRPSHAGFRRYGHHVDVILGKTRRESALSPGGRATPPKATTYPGAGSCGAASTRRVRRDPSPHQTSSWETAHYVLGRYVVHCTHLPPYLASVIEFELRTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRC0</accession>
    <name>A0A4Q9PRC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DHS-like NAD/FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_949782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRC0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRC0"/>
    <dbReference type="OMA" id="KCATIAF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU56906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="244" mass="27133" checksum="7F677111309DC513" modified="2019-07-31" version="1">MWRSLDATALATPEAFQENPSLVWQFYHYRRTSALQAKPNAAHEILAKFSVPQYLRKVAPAAKFFHLVTQNVDGLSVHALQSLTSRLAPDTFETAITVDRRRPPLVFPNSLLEMHGRICDVQCTGCDYRQEDLSDPLCPALGAADASFQDYHDAGSKEVNIPEEQLPRCPACGALARPGVVWFGEKPYHLDEINSIVYKADMCLVIGTSSTVRPASTYAFRVQRHGGKVAVFNLDPSEKDERAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRT0</accession>
    <name>A0A4Q9PRT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_949610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRT0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10768" checksum="57F8BFF49A757C0A" modified="2019-07-31" version="1">MQLGGLATSGRRYEDEEVRQWLYPPREGQDLEVQLFQIGTARQEFEEIFDAPNGVTKDVVPIDSKKPKFWKDVGGQEPEFLKVQTAQVLSVSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSB9</accession>
    <name>A0A4Q9PSB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSB9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9726" checksum="CD1DF1F3B0CD4E13" modified="2019-07-31" version="1">MLDAEREETATVPPPVPRSRWGSRNSDPPRAMLSRWIRRSPLARIDRVAMVLFLEWMRTALLVWAAWCGLSLAYIPTRRLTCTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSL0</accession>
    <name>A0A4Q9PSL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1039843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSL0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="38160" checksum="A45EC2EDE7CDE3C4" modified="2019-07-31" version="1">MPTQRALVIPAERAPFKLVNDWPIPKPGPKDVLVKLASIALNPADWRIQSGGAPGFVKEYPFICGLDGAGIVEEVGSEVTNLVKGDKVLFEGAFDNTRATFQEYTLSPAAFTAKIPDNISFDQAASVPLCLATVVTGIWAQEEGARSAKLTPPWEEGGKVKYAGDVAFIIGGSSSVGQYAIQCARLQGYAAVIATSSLKHAEFLKSLGATHVIDRHLLPAEIQAQVRTFAAGKPITYVYDAIGDRDEQRLSYELLEDGSAFVTVQPIFHEYIEDLVTEKKPVTRVYGAFDVPGNFKLGLEVYSRLPGWLATGVIVPNRVEVVPGGFTGIPVGLERLHQDEVSGVKLVVRPAETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSN0</accession>
    <name>A0A4Q9PSN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine proteinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1039847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSN0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PSN0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF39">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="862"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1061"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="514"/>
        </location>
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        <location>
            <begin position="550"/>
            <end position="566"/>
        </location>
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        <location>
            <begin position="695"/>
            <end position="711"/>
        </location>
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        <location>
            <begin position="741"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="864"/>
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        </location>
    </feature>
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        <location>
            <begin position="894"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1128" mass="122827" checksum="7DA4B29313E30631" modified="2019-07-31" version="1">MIRHKSKPTPREIYLEKKRREEEEKDASLPPGLVNHGNTCFMNSTLQGLIATRPLHDLVHFQSVPTSLQPAEGPSILARRSPQLTNGHGIGGADELAWTEGMPLGDIFTTIMRKAWDIQDAKRRETMSPKEILTTIGRKYDQYLDFRQQDAHEFLRHMLDAMRMEELDIIKKRQPPPSSTKRKRARGGSEPKSTPPPLPSPALSQSDPPAQAHSPGIPSTPPQLPQQTSDLDRPLPPVPNGGEKLESFVDMLFGGQLASILVCEKCKKVSVTYEDFNDLSLSIKPEDYVNKHHRKRDRIKRIARKLRIRPPAAYGSGSANDSAGSSAKARASSVPTSPVRRSSELALHEEEPPTSVDPRRRSFDHPGEDERRDAVARLVSTVSAPSGLDSAIAEDDETDAAEREKETELERAEETDAFETEGGTDWTHVGADGPGWGAGAGSEEKPKDKQGKEKDDAWGKIARRISVSMKLGGREKDREKDKDKDSRPSSRASERGRKPDIKDAFRVKRSETRSPRMTSLAPGASAHEPAPEAADASEVAKRATSPTPNSPRISSPLRPPYSRRSSANPFARSNHEPPIKSRAVSVDPKMSEEDMAYLRRILADVHPVTGNPLSILQTAFSGNGPVSAGQVGNTAALATQVLWAKLGHLPGIEECLRMFTAVEILDGENMVGCHRCWKIANGLYILPLRSKDGFDADSDTESDESSGDDSSDQSADKAPISVNPARSATEPSRSETEDSGVLSSPDLSSGRVSPASTSLVSTVVTQATSRPGDTASVSSAPTTITVPPSESSTSMLHARKDSLLSPQPSTYGGLPIPQISTTEPDTPDGGILGPALSRDSWTQTWPSTRAVVGMSLSDDSLLTPKRRRQRRALRKDGADDSGSSSDDDFDDSASDASAPSSASESSASPFVSPRSSVEKLTDPNPPSELPSPKPAHRVQDKKVPRSKQVVPRRMYKRYLISTPPPILVIHLKRFQQTNKSHAMSFSGGFKKLDEFVSFPEYLDLAPFLVPKREDFVGKAGKGKTKQQEKCMYRLYAVVVHIGNMLGGHYIAYTALPNSVPAPGPTTPSSESDKSVPPASGSSDSHASQTSETQRPTRKWAYISDSTVKLTTLEEVLKAKAYICMYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT80</accession>
    <name>A0A4Q9PT80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928748</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT80"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="577"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="625" mass="67172" checksum="4F940410B69D6912" modified="2019-07-31" version="1">MSVTVTAMAYTPSPQASTPTASTSPLVIRRGRSATPLFLHRTPTYHPHPRSSASMSQLAQPRPPNASMSQLAPNRVPPSTFNRASAPPTSSRGASESMRIRMAERSSSSTEVKHIPKLRAAMDHSAPPSALSRPSTGHCIRPPPTDDCVQPSRASPTPSTSVSASPSPSPLPSLLSSPALVDKDLPPVPSPTEPPTPSEEALDPVFRFPPLPRPSRIPSLRPLSFDAEATIRELEELAASIMSQDTTREAETLAASFKAYGLPTIEINLWRDNEMPAAIPEESSPITPRPLMFTRKDVPFAASPGDSFQSNASLSVPHIVVTDPSTEDLSEQLHRSLPALVSPGGKTEAGQGDDEEELQWVCDYGAWGMSDKGKWRASVGEEESSDHDLSPKSKNTPLPRASIDNTYIYEPMGAPEFLVGSSTSPVVRAMTGYRSHIRPSKRAATEAFRARRRRAAPLALANPAQAEWELETTLANALFLGTSKPPRRPQTAPNTARPRQPTPPSTWLHLKRSMPSTAGADGPPPGRAEDPGVVLHTSTGEGESNRRSDPIPVIPHTLFPSAMFSTHDLHPLRFQEGDRTSQGVPWPSIPAGSGGSGTGSEPSTPRPSGRPRLKSLKGLFKHWSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTM3</accession>
    <name>A0A4Q9PTM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 19">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="14">IMP dehydrogenase</shortName>
            <shortName evidence="14">IMPD</shortName>
            <shortName evidence="14">IMPDH</shortName>
            <ecNumber evidence="14 19">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD310DRAFT_928407</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14 19">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="14 19">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14 18">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="14 19"/>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTM3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTM3"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 17" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14 19" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 14 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 15" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 14 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14 19" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="135"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="197"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="438"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="14">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="473"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="291"/>
            <end position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <begin position="341"/>
            <end position="343"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14 16">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="381"/>
            <end position="383"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="404"/>
            <end position="405"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="428"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="540"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TBU57816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="559" mass="59376" checksum="7143ADB5E86F9C6C" modified="2019-07-31" version="1">MPANDHLDPATAVAVLKSYERPDGLSVADLMDSRVHGGLTYNDFLLLPGKIDFAAQEVTTESRITRNVVLKTPFMSSPMDTVTESEMAIALAVSCSRCLEPCSSLLGGIGVIHHNQSAESQAAMVRRVKRHENGFINEPVVLSPDHTVEDVLDVKERLGFAGIPITDNGKLGGKLVGIVTNRDISFELPSTPLKDVMTTNLVTGTQGLTLQEANTLLRESKKGKLPIVDSEGRLTALVARSDLLKNKTFPLASKNPESKQLYAAAAIGTRPADRDRLKLLVEAGLDIVVLDSSQGNSVFQFEMLRWIKQTYPKLEVIAGNVVTREQAANLIAAGADGLRVGMGSGSICITQEVMAVGRPQATAVYAVAEFARKFGVPVIADGGIGNVGHIVKALALGAGAVMMGGLLAGTTEAPGEFFWHDGKRVKAYRGMGSIEAMEQGKPGSASAQRGESGPGSSKAPAKSSTIENAATSRYFSESSAVKVAQGVSGDVQDKGTVHAFLPYLYTGLQHSFQDVGVRSVKELQDGVRAGTVRFELRTTSAQIEGGVHGLNSYTKRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTP8</accession>
    <name>A0A4Q9PTP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_928184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTP8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU57882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="318" mass="34222" checksum="1840734954EC22E7" modified="2019-07-31" version="1">MLFYLLFRIISATAAFLYPGYASYKTLSQRPANEADLERWLMYWSVLGCIVAVESVAEWLVSWLPFYYFFKTIFLLYLALPQTSGSAWLYQTQLRPFFSAHENQIDTALAQAKVYLYTSIQRLLRRGWEQVSGAVSQGPTQSAGSSLLEEDAASHTGAPPSTHDPVSGPAQLVAGLWSTYGPSLLASGAALITQAQASAAQAAANANASAQASRSSRSRGSAEDRRRQLEAELASLGEEPAGYDVSSATSSPAFVAVQMPAPDNGSSSKSAFEEVDVPSDVEPEGGHPVSPRPDQKRTSWFGWGGASAGSGYERVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTR5</accession>
    <name>A0A4Q9PTR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1039611</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTR5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044190560" evidence="2">
        <location>
            <begin position="24"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="146" mass="14319" checksum="BC7769D08DA1BEB5" modified="2019-07-31" version="1">MFLFRAVFIITTVFMAFVAQVSAIPPLTRFMLDAVPDGSESAADSNSNAVVAPGDHGADTSASVDQDVPIAVESSPVQEDTAVESSAVALAAQPSAADIAASSAVSVPSAVVGAQLAQANAAGHLGVLGSTSVLVGSVVAGIVLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU37</accession>
    <name>A0A4Q9PU37_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1017265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU37"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17391" checksum="CA8443ECDEE9902C" modified="2019-07-31" version="1">MLLERRRTCDRGGSLTSYGMPISIIQNQRAQEIEGPSKGTSRRRSENAHESPRGNVYCANPRKIGSAWQQHSSSRTSSSKAEFSEGVSYLHIFDFDTNAVERLARSAEKAALQQIDRKQAEALKSKSNSGCYRLRRRIPPAARLLHHSPVLPQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUE1</accession>
    <name>A0A4Q9PUE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_851854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUE1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="38057" checksum="B16E6394A0EE29B5" modified="2019-07-31" version="1">MSPQPGVYYGPDEDDNTKWLERYFLAGDFVTGTGFGVQVVLWSTCVTYLWKERRRSWKTLFLIGYLCLLLAVQFIFCIVQARTVQVVYVENRNYPGGPWQYFLDTQFLAINVIFDATLFIGTFLCDLLVLWRCHIIWAASGRGLAYAVISLPAIILVASFVLGTLWTLQASHPGLSLYSKEPLAFGTAYFTLSLSVNIILTALILVRLLMYRRTHLAHLPPGHAKHYLSLANLIVESAALYSVFAIMFLVSYALNKPINQIWLGTAQSAQQVASYLIIYRVINGTAWTKEAMETQTLNTVELRATSSSRPRKSTGTSDVQLTTDFTVSQDFAQKDEGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV01</accession>
    <name>A0A4Q9PV01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L17/L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_927342</name>
        <name evidence="5" type="ORF">BD311DRAFT_752777</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV01"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV01"/>
    <dbReference type="OMA" id="IRQSKPW"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_uL14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU31526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="139" mass="14700" checksum="F088BE531292E8D4" modified="2019-07-31" version="1">MSKRGAGASGNKFRMTLGLPTGAVLNCADNSGAKSLFVIEAFGTGSHLNRLPDAGVGDMVVASVKKGKPELRKKTMPAVVVRQRKAWRRRDGVFLYFEDNAGVIVNPKGEMKGSAITGPVAKECADLWPRIASNAGTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV49</accession>
    <name>A0A4Q9PV49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_819663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV49"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="40932" checksum="4B3D1A5A983C8041" modified="2019-07-31" version="1">MQKLEIVDAPEPVSSSSRHQWVGEVDLPEHMEPLLMESKRRFVLFPIQYHEIWQMYKKSEASFWTAEEMDLSKDLHDWNNRLNDDERHFISHVLAFFAASDGIVNENLVERFSNEVQAAEARCFYGFQIMMENIHSETYSLLIDTYIKDPKQREHLFDAIDTIPCIKKKADWALRWISDKQSTFAERLVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGMHTDFACLLFSHLKRRPHPDHIRKIITEAVEIEQEFLTDALPVALIGMNSKLMCQYIEFVADRLLVALGDEKHYGVTNPFDFMDMISLQGKTNFFEKRVSDYSKAGINTSTTTATTEVNTSKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWD3</accession>
    <name>A0A4Q9PWD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_442480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWD3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10163" checksum="D16052E4D0AAD6DD" modified="2019-07-31" version="1">MSKKSPQYHGWVQLLLSTSLQAGSQPRACTTQLYGGNVHGASTAGMLPKTAYVMLRSALIGDFQQRTRYDHLRPALRATHQDSLHTQLRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX85</accession>
    <name>A0A4Q9PX85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_976708</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9973" checksum="564A770FD527B883" modified="2019-07-31" version="1">MGFWGVQTAALHSAILADQDQRGVSSRSPVYTTNNESGDSSDRRHNENGVAVQIVGFFQQYLGIFKELQGKNLYLTGEGHAGMTQDAFRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXM7</accession>
    <name>A0A4Q9PXM7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXM7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020417313" description="Secreted protein" evidence="1">
        <location>
            <begin position="34"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="14200" checksum="53DCEC26009C9B0B" modified="2019-07-31" version="1">MRSKAFQIRAVYTLPLPCHSCLAVAACVLVASAADCPLVSSPLARTSTDACPLHPSCSSDALCPPVAHCFPWHPQSSPACSSLVTFADPHRAAGSCTGDVQKHAPDMYFPAHGPGSRFPLCFLSSSSLFPSRLCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYQ0</accession>
    <name>A0A4Q9PYQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_924129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="11084" checksum="E403D44C239C5E95" modified="2019-07-31" version="1">MPRMRRAIKVPSVPSFLRRHLAVVCTNLIAWAEISTSSNVSVSRTNHKSARSRTVYILWFEDIDISSRMLMRPLMPLTLNPPVSLVFRSSVHQREH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ72</accession>
    <name>A0A4Q9PZ72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923661</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ72"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11796" checksum="AE11B62DB9C6734D" modified="2019-07-31" version="1" fragment="single">MVDRTVRLSGGLYSTRLPLHLATIVFLLPSFEVCRPKDVAICARRSSVAEKQRITTNCTLQPLEWPARDAGETSADAAITKHKRTARQPNQTNERNNNPRESVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1P9</accession>
    <name>A0A4Q9Q1P9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sphingosine hydroxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_846626</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1P9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1P9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="171"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="325" mass="37699" checksum="B0F53EDFF530476C" modified="2019-07-31" version="1">MTATNATTYFLDASQLRYLSNHHPVYYTPRVELLPGFADHLFALAVPIIGYWVFSLFFHCLDISNLRWLDKYRIHESAEVKSRNLVTRTDVILAVIFQHIIQTLVGIWWVEEKPTGSQVDHVANMLQLAPTLARGVTLVFGEEAGAQLLAERGADGLYTLYWWAIPIAKFFFGMFFIDTWQYFLHRAMHMNTYLYKKFHSWHHRLYVPYAFGALYNHPLEGLILDTAGAGVAEWVANLSTREAMFLFLVSTLKTVDDHCGYRLPWDPLQLFSPNNADYHDIHHQVIGIKSNFSQPFFIHWDAILGTRMTRKDIEERRAKQTAKTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1R0</accession>
    <name>A0A4Q9Q1R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_814120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1R0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1R0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="741" mass="83217" checksum="2F3238DA3EF3C3CB" modified="2019-07-31" version="1">MSDPSGDAYSPFGPSLTAVLPVTSASISHLEYHLRSLLGTSDTLSDVVVLSPRSLHAQIRQALRLILSEEEAHEVELSTSQWPEGLGLGSALIQAARRVTTEWVLLADEEGLEHFDNRTRDILLLNPPPSDPLPMGPRGVDFRSACLEPSFTPKTAAYLVPPLALPVSLLPPARNIKPTDDPWVTLGDSISRSTSRLSGGLAIGSSNGSLAWCERYVVGNGTSLRPPTGDHGLQEPMHSTQENGTTPLTASGVFLFAAYAREARFLVHLACELVRQGHEITFLVLQHDGFVGQDLESQLRVCQAAVYLFHSHSSADLGHLQHELVEHIPHNMDVVVSTLEDEFFFQLSGRFSQNNVRGRTSVVRIPEEDLPYCDWMSAVDLEGWKNWHVPQIELSVITDHRPYSLQRLLSSLANARYFGDQVDLRINIEQTADTGTLQLVNDHRWEHGSVFYHHRVAHAGLMAAVVESWYPKGNDTYGLLLEDDVEVSPLFYAWAKLSLLRYRYGQAESRSPNLYGISLYQQKNIELHPDGRHLFNARSTFEAAGLVYPNTPYLSQIPCSWGALYFPEHWREFHEYLVTRLNASVWPLDEVVVPGVRSNRWTRSWKKYFIELVYLRGYVMLYPNYADYMSLSTNHLEVGSHVRDIPIETYLRKKKLFNLPLMPLPPATLPRDLAIMPSTGLLELPEARLPDWHALPVLDLLGTISNETMITLRGGERRTELTGCDVFTARKNDVGELLCID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1V1</accession>
    <name>A0A4Q9Q1V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_813980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23608" checksum="B14E186AE3BF32AD" modified="2019-07-31" version="1" fragment="single">KRIGRAEQPPTSQEANPDEVVKIRQRLAFLCHDLCTFGANPEAMERLNLSLYPHFLGPPYLSEEEAAFALSSEIRTLRNVGPPPSLDANARDQHSQSLAVFLEGGMAAIMAAREAKHNHETIRERDFVLCTSHDLAPLLQDACAFPKQHFETRAFKDAYKQWEKGLRKANQKGERLDGCTRCDCCWPWSGIPRRSDMSIFVLRVSMLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1Y1</accession>
    <name>A0A4Q9Q1Y1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_947307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1Y1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="388"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="752" mass="82445" checksum="46A72A693D5FC73F" modified="2019-07-31" version="1">MAPSWRSLASAASRSLKGYIAQQRDLKQGYPLSRSSGAEATKKQSWSQWAGQKLRRAGQGEYDTSGDRLTLFPGWAARRYSERPQENSDGDRVDAPFDVDVFVSGYACKLTGIGFTTRAGRTFLRLAKSFAALPKLPNAGQSKSTEDLLGGTRLPPLPDEITEETEMQALDDQLHRLDVETRSIDSGRTADTLSMKSAQSNDSRTPSSSAASSSNSNAFVQGETLAPPPIIPGTSTELHRWHANLEARLHPFWSSVLPNRVVRISLYAADPSLYNSDDQQSSSSHSSVAPEREPIVTRNVITAVDGSFQLKLSVPWERMCVHPGALHVAFGGSELEQDLFVVAELLAPPSPGPATPTGQHQQFRELPSIFSPVTVAASIPVPLTYSSIRVISDIDDTVKLSGILSGARTVFHNVFVKDLRDSVIRGMGEWYTGMWKRGVRFHYVSNSPFELLPVVNEFLQLSDLPPGSVRLRSYGGRSLFNGLLSAPAMRKRAAVVDVLNHFPDARFFLVGDSGEQDLELYAEFARERPEQILAIFIRDARARDDDSVHPLDDPTGVEAFRWSMDAGLTTPGSAPTQTSGRFSQAMRRANSKLPLRSMSQSDAVPQPPPPAAPRKVARSYSGADVASRSSSNSSGSSTSPTDYFSSAARSHSPITEEPHESPPMEMNARSWPPSGFSKPPPGSQAERRESGFYSQAQLSTPLPDMGKMADLQMRLWKARLDVPPQIPLRVFREPEECVEVDEVLEKLQVRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2H1</accession>
    <name>A0A4Q9Q2H1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_845880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2H1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2H1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="586" mass="63266" checksum="2B88390A3B8AAD1B" modified="2019-07-31" version="1">MEFDAIVLGTGLSESIAAAALSKAGFKVAHVDNNQYYGGDEASLTLDELAEWADIRSGRKDTPSSDYLATQKERYTSISRSESIPPQSRQYAVSLAPSVVPSIGSHIDALVASGVSRYGSFKLLEKVAVYDRPGFVQSVPGSKEDVFKSKALSLIDKRRLMRFLMFAAGEFEDKKELEGKEQMPFSQYLREVFSLNGKAVNAIAYAIAFCTTGEEHTLPVLRRIRQYLRSAGRYGASPFLVGHYGGLGETAQGFCRTSAVKGGTYILGRRVLSVKASSLADSLEVEKAASDSAKTAARYEVQLEDIDEQLTSTILLSAPDYVRPSAPITSSSHDVPSVSHAHYPIARCIAILEHPLVFTPVDAPEETPAPEVEESIEGVEDELSDKPAPPNYEVDTALLVFPPGALPDGSTTTAAHALVTGEASMSAPRGKYILNISLPLPTSDPSSPKELLRPYLEAALSLAISPSSPETTPTRPLFTVFYTHNPPSGAAPPSTPSDSGAILTPPPTQLLPAIADVATENAEAMFWKAVEQLKAAGVRRSVVKESYKKSDGEEEKVYDERKPEEIDSFWPPLDATEEDSSTADEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2H4</accession>
    <name>A0A4Q9Q2H4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">aspartate kinase</fullName>
            <ecNumber evidence="2">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_946803</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="2"/>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2H4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2H4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/glutamate/uridylate kinase" evidence="8">
        <location>
            <begin position="39"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Aspartokinase ACT" evidence="9">
        <location>
            <begin position="534"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="611" mass="65748" checksum="85291584C50D11EA" modified="2019-07-31" version="1">MSAASTPSPTSSRSSSLSSGQGPCTPPNMHQNTIDPAAKWLVQKYGGTSVGKFVTKIAEDILPEYLDQHKVAIVCSARSGSTKALGTTNLLLRAAAEALQRSGSVSDTPGTMSPSGVFTRLTQYQSPFASPGPGKASPKSESIALALGMTSITEQPPSFNTTVDVIRSEHVNAARASVRNPEILKDLEAEIERDCDIIRSFLHATQVIDEISPRSRDSIIGFGERLGCKLVTAVLRDRNIDAEFVSLENIIPLSEGDNFSDSDTLPQDFYDRVADLVAGRIKACGNRVPVVTGFFGPVPGSLLRQVGRGYTDLLAALLAAGLGASELQIWKEVDGIFTADPRKVPTARLIPIISPEEAAELTYYGSEVVHPFTMDQVIRRKIPIRIKNVENPKGGGTVIHPDPDVDGYALLNGNDSCSPVIPTTTTAVSRGLTPLASPPFDKHAQVRQPTAVTIKEHIIVLNVNSNRKNVSHGFLATIFGTLDRYGVVVDLISTSEVYVSMAIEENLDKKVLDRVVRELQKCGTVTVVRDMAILSLVGKSMRNMIGVSGRMFTTLGQGNVNIEMISQGANEINISCVIDGRDAVKALNLIHQSCLQIKPEGERGRVGPWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q368</accession>
    <name>A0A4Q9Q368_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_921312</name>
        <name evidence="6" type="ORF">BD311DRAFT_716751</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3YL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q368"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q368"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000100">
        <property type="entry name" value="SH3 domain-containing YSC84-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF2">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING YSC84-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="504"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="355"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU31448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="563" mass="59692" checksum="2C63BE6B241A8F02" modified="2019-07-31" version="1">MKFNTPLPQPLPKECQKAAQIFKSFVDSSNNGLDGVIPRSVLENAKGFAIFTIFKAGFLFSARAGSGIVIAKLDDGSWSAPSAIGTAGVGVGGQAGAEMTDFLIVLNSRSAVTSFMSAGSLTLGGNLSLAVGPLGRNGEAIGSLNTSGKVAAMYSYSKTRGLFGGVSIEGSVIVERQDANAQAYRADVTAKQLLSGAIPPPDWASPLIKTLETCTGMPGGRRWVQDFRSHRADDPYMFGSVESPGLEHGPAGSRYSLDSPSVESPPIGGSANGKLSKKKKDKAGSLSFPPMQWGRQKSSGSYFSEFHDPARAPEPADTHIATPKLSPEDRPSPRLDRVLNPATGYFETRFQSDYISDDQLRQHPPLSSRRTNSDVPDLLTLGQPASAGVGARKSVGDSWEPDSPFNDLPGGGFSEARSNMSDATSHRRAFSAYAPSATSQSLNGTRKKGSNPFEAYAAHEEDHFDDDLLGGGAGSRSAATVYGMSPKPKIAPKAELTRPLLPHEGVARAIALYDFKAVQPGDLSFSKGQVIIVTEKSDDTNTWWKGKLEGREGVFPANFVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3B3</accession>
    <name>A0A4Q9Q3B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Telomere replication protein EST3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_974965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3B3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="826"/>
        </location>
    </feature>
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        <location>
            <begin position="872"/>
            <end position="884"/>
        </location>
    </feature>
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        <location>
            <begin position="1028"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1049"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1073"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1227" mass="131613" checksum="3FE3A7CBFEDD4FFC" modified="2019-07-31" version="1">MTDSIPNPWIVEYLVDIAEQYGANLAAVPRKDKAAKAQLVKFLTFPPPDKDEPCALWVEISDKKHIIRARLSADAIQKHDANPAHGGKPITSRKSAFVLLKDFRPALGRVARRDGQSGMTEESTLFLDVDTIVLKGAFGEAMWGSPVDSSNDPKVRDWIHGLRQDGGAGNVLKLRKQEAAAHAAEREEFEKKAAMKPAAKPSMQTTINPAALDMKVRVARKSVAQKPKKSINDEDSRQALIPINKEVLRRAAWKRFHANMVKYFRPPDDIFEQLISLCDGSSSKSAIRVSKAAQRQQPRSRSGSPRAGTPRFSPPPRSPSHWSPSVRGSPQRDPAGDSSETEEEPSDDGMEVDDPNSAQVNGTMDEDPPDPPEANGGIDERRDEDEDAAANHSSSSLTMPPPAQPRPAPTPSDVPYATSQPQPQSQVAEPPSQAADHDLPPSSLPIPPSSLRDQLSSPLTQGRDIYQPSSVPRLGWSASEPLIRRVPPPVYSMLRPDPDASGEGRVLVENSDTASPGSQRVGMSQSQSHIQSQSQSQSQGRDEGEEERSQEQRGSQYQRPSKLRNELRHGRTRSAEREGDVHAAVTHDEEPVPVESSQGRIEGVLATEAEEEGPPALSQNVQNLSQPPSQDMHDPLHSPSQESQKSRQSLSYQGDSQSQDKTAEAPPAPSEAPVAGAEEAAVYESEEAPVTLDENLPLADRTVVHVERASPPSPMQVDEEPGSLVENVGNAPTWAAIKSAPSTDSEGADSQEEEADVDQLLSDPIDMDQRDRAPTTKTRRTGAGIQGARGQLDPDDARTAAMVDRYVSGIQKKTAKEKAQRRDGRPSAEVLASRRPTPAADEQPKARLAQRRNKGQGGPGVPYDRGVFTNEESLKLTGEDEHPSPVDSPPASKHSRHDPEVWTAPTFMRKRSRSKEDIGSRLAKANGKPQPSAVLAAGTTAVQKRPASVSPELEQEEPSTKKRKTSTAAISVSGDNAKPRLEQQQAGQRDRKSEHVSAAASGPSTLSRDRTQDLQALPKKPTQTRPPSDAASASDAGSTALNSKYLDLRAASRSSSRSSTRAPRAGTRGPVQTIPTPSEASSSTGKGKARTLTVTDERKGSVSSSMPRSKPVLPVLSGAKTVSSRGTTQRSSDPAKQGSLSTHAVPAPSGSSSGGGALVSELPPPGPDKPAEQRKSLLDGYKVSLDLVKVPGGPPLLDWNDLLHILLRTGQARARPASGASRSGGDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3I2</accession>
    <name>A0A4Q9Q3I2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_921602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3I2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="22"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="323" mass="35958" checksum="FE3B90E161B69170" modified="2019-07-31" version="1">MVLSGSPDGDPLIITNSQNLSYSEVACVVILTWDVIITLSDEVELIWKRRWTAAKVMYLIARYLPWLVQLALLAINVNGTTGLSFTSGQCAAWQIVQGTLLQAIVTTVDVILIIRVYALYHGSRMLLVGLGSLFSAEVASLCYILVKVTPRLTYNDECYVVSSPSIFQYYWVISLAFETLLFTLTVGKFLDGIRQGWGRAVMVQQFVADGTWAYALIFLTMLVNMMFYKYVHSELTGICYTWLLVVLSFAGSRLVLNPRARAAPPDVDLSDIELASMSIQRRRSVFTGEVISLTLEHAPQSPASEKTGYVSYREDSEVASTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3M3</accession>
    <name>A0A4Q9Q3M3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Mitochondrial import receptor subunit Tom22-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_920037</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3M3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3M3"/>
    <dbReference type="OMA" id="LVWIVTT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11 14" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU61862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18457" checksum="209824B1108EAF6C" modified="2019-07-31" version="1">MVKVEIVEEKEQDSRSPYSSPSSSRTSSSVSLSSVGSELDGEESFYERIVALADIIPPTTRQSISTKLGNTVGALKTTGKVVGNLVWIVTTSALLIGLPLALVLEDEAKIVQQEKEMLAQQQGAQVRLIPPDTLFDRLTCTPTLTISVQMLAPPGSLYPQPGQPQNPPKSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3N3</accession>
    <name>A0A4Q9Q3N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_845002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3N3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3N3"/>
    <dbReference type="OMA" id="PTATGDH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11525">
        <property type="entry name" value="SYLF_SH3YL1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051702">
        <property type="entry name" value="SH3_domain_YSC84-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033643">
        <property type="entry name" value="SYLF_SH3YL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007461">
        <property type="entry name" value="Ysc84_actin-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629">
        <property type="entry name" value="SH3YL1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15629:SF7">
        <property type="entry name" value="YSC84 ACTIN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04366">
        <property type="entry name" value="Ysc84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="280" mass="28991" checksum="ED85D00976C8F6BB" modified="2019-07-31" version="1">MSMLDKFRKGATKAGIQASAFLKEGSNKLANESQHFVQGFTLPGEAEKAAKILESFLADPEHPESALNSIPKVVLQRARGLAIFSVIKAGFVFSGKAGSGIVIARLPDGSWSAPSCIATGGVGWGLQIGADITDFVIVLNSEEAVRAFALGGNVTIGGNISAAAGPIGTGGAVQATLAHPAPMFSYSKSKGLFAGLSLEGTVLIERKDANKDFYGSAVPARDILGGRVPPPEVASRLYEVIEAAEGVDESGLPENAYVPTAEGDHMDIRHGGMVFDAEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q428</accession>
    <name>A0A4Q9Q428_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_904543</name>
        <name evidence="3" type="ORF">BD311DRAFT_779093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143435">
        <property type="protein sequence ID" value="TBU27142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q428"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q428"/>
    <dbReference type="OrthoDB" id="406505at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22191">
        <property type="entry name" value="DPBB_RlpA_EXP_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051477">
        <property type="entry name" value="Expansin_CellWall"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31836:SF28">
        <property type="entry name" value="SRCR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040684020" evidence="2">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU27142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13184" checksum="27B89C74D69E8360" modified="2019-07-31" version="1">MSPFTAIAFFLALSATAFAAPTSEGTASVAKRSRTGRGTWFDVGLGACGETNVNSDKIIAISADIYGNGGYCNKGVTITNTANGKTATAIVRDECPGCGANDIDMSPSLFQELGSLDTGVLTVSWDFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q550</accession>
    <name>A0A4Q9Q550_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q550"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="304" mass="33447" checksum="973DFE0F9ED5BA9C" modified="2019-07-31" version="1">MPEAVQGYPCRGDLMPSYSPRLLSAGPPSIQVTLASLWTPHSPIFRRHSPITVTKYLQATSPQLASSMMRSGASSGRVASTCPLPSVRSCDRQVEDDIVCWACERRWLACKMWYQANDEGLMEPFMRRAESNADLRAVLEFLSVPREDERAGRIGLGSDLPSADTIKKRPPFRVVDPSPVNSGSDCDCPPAGKRFLLFGSRSWRHLRSIFMEARRESRDAVRAWVAASLGPLSPLCRSDEPKLRRRSGGLSAVSTSPLAVHHGLAAIWANCDRPCLSQLSPAYGSQFFGSADNASGSRFMKHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6J7</accession>
    <name>A0A4Q9Q6J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription activator of gluconeogenesis ERT1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_904137</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6J7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6J7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF7">
        <property type="entry name" value="FUNGAL TRANSCRIPTIONAL REGULATORY PROTEIN, N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="24751" checksum="BFB36D333CC2A811" modified="2019-07-31" version="1">MLSHLLLPSSNAHLFASGPSTDHFRPQDDIHAATGHQNNTNDVSGWPWCQSCRPFVQILLAQGVASVAGQGTTSASWALTSPFPEYVCIPALVHRSQLASFTASIASPVEAISPALSPQEQMGPTAQSGTSAAQRKTRGVKIACTNCRLANKRCDEGRPCERCVKNGLEHSCVSAERKRRRRTVRQTATAKLTLSTTQVSVETPLTSEATDRRPYGGHSPCYGWHVVCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6P9</accession>
    <name>A0A4Q9Q6P9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">L-lactate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_809044</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6P9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6P9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF75">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_4G07050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="30"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="109"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="364"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="387"/>
            <end position="388"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="50150" checksum="FABD5482CD8BAB5B" modified="2019-07-31" version="1">MDPTNKPKGPSPHYSLYQREVFKPGGEKGILPSFSVHPDELQESTKKKLNDRGYFYANSNAGLGWTDRANREAFYRWRIIPRTCVDTNTRDLTTTIFGHKIPVPIMFAPIGINKLYSPLGELIPARVAGELGMPYCLSTASSQPIEEVARVNDEAASVKNESNAVHQYNGPNGGNAKSPRFYQLYMPHDDEVTLSLLNRAWKSGFDVLMLTTDTWQLGWRPTDINVANYTHVHAFSSDVLTFYYPGTPGNELGESDPAYMAKHHDDLAQDKGHWIDSSVWHGKPHTWEKVRWLIGEWKKISDGRPFVLKGIQSVADANRALEIGCDGIVVTNHAGRQVDGAVGSLDVLPEIAEAVGDKMTIIFDSGIRTGADVFKAIALGAHVVMIGRLFVWGMSHEGVHGCRHVVKSLLADLDILMTVAGYRSITEDVYKNMEALRYSPSGVPPGPAEHARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q794</accession>
    <name>A0A4Q9Q794_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q794"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020552006" evidence="1">
        <location>
            <begin position="19"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7807" checksum="2121CC483E978D3E" modified="2019-07-31" version="1">MLIISLLLVNNFVAILSCMSERRSFTSHRFFGCLSAPTFLVSTIWLVGKVQGGDTPHLTSGMVHPAWQAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7Z3</accession>
    <name>A0A4Q9Q7Z3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_915674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7Z3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7Z3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="319" mass="34992" checksum="940D64948540D8DB" modified="2019-07-31" version="1">MSNTIKASVVQAATAAYSLPDTLDKLERLTRLAKERDGAQLAVFPEAFIGGYPKMSTFGLVVGDRLPEGRDEFVRYAKAAIEIPSPAITRIEQISKETNIFLVVGVIERDNGTLYCTAVFVDPEKGYVAKHRKLVPTAMERTIWGQGDGTTLPVLTKTFENTQGPPVETKLSATICWENYMPLLRTWYYSQGTQIYCAPTVDARPLWQSTMTHIALEGRCFVLSACQFSQEKDYPPDHAVANAEARDPENVMIAGGSVIISPLGKVLAGPLLGTEGIISADLDMDDILRGKFDLDTTGHYARNDVFQLRLVDPAVSSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q887</accession>
    <name>A0A4Q9Q887_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="15">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD310DRAFT_917005</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="15"/>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q887"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q887"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 22" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043893356" description="Pheromone-processing carboxypeptidase KEX1" evidence="21">
        <location>
            <begin position="26"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="560"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
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    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TBU63221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="613" mass="67739" checksum="ADB297213E6BF206" modified="2019-07-31" version="1">MHPALSLHLASLLYLLVSLVKHTSGAPTDVPSAASFYIPHLPDLHQDERRPLHMYGGHLPSDPGASVASPSDVTAHLYFFMVKARRTADKERIVFWLNGGPGCSSFDGLMMEIGPWRTDGKGGLKAAEGGWEEYATMVFVDQPAGTGFSYAPSNKFDHELPEAAGHFVEFLRNFYQVFPEYKNVDAYITGESFAGQYIPYFADAVLDSTLDIPLKGAAIGNGWMDARRQYPAYLDYSVKHGILEETSTEYKAAKDVTDQCTAELAKITDREPVHVDVCENVMMSVIAGKNHEEQGVAKCLNIYDVRLEDSQPQCGMNWPPDLDAVYKYLARKDVVSALHADRAPGKWVECKSRVHVEFSTRTSNSSITVLPRVLEKIPVMLFVGDQDLICNYVGVESMIQAMRWNGETGLGKVQTQSWTVDGTSAGTWVASRNLTYVKIINASHMVGYDVPHVAHDMILRFMGVNFTAITDGSARIPSAVGEDAKPLPAKLDEAATPSPVSTKTPEQDKAMWEAYYNAGSAALVLVLIAILVGGFLWWRSKRNRLRGLPFSTHEENIPLNSALADEPNGNGNGFRSRKGKQRADSLPEEEAIFDVGDEDEDEDDDDRRSPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8C5</accession>
    <name>A0A4Q9Q8C5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">[histone H3]-trimethyl-L-lysine(4) demethylase</fullName>
            <ecNumber evidence="4">1.14.11.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_869978</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 2-oxoglutarate + 3 O2 = L-lysyl(4)-[histone H3] + 3 formaldehyde + 3 succinate + 3 CO2</text>
            <dbReference type="Rhea" id="RHEA:60208"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="1.14.11.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the JARID1 histone demethylase family.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.67" evidence="4"/>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q8C5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034647">
        <property type="term" value="F:histone H3K4me/H3K4me2/H3K4me3 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.650:FF:000035">
        <property type="entry name" value="PHD transcription factor Rum1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.60:FF:000016">
        <property type="entry name" value="Putative Lysine-specific demethylase 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="ARID_dom"/>
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    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
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    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003349">
        <property type="entry name" value="JmjN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048615">
        <property type="entry name" value="KDM5_C-hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004198">
        <property type="entry name" value="Znf_C5HC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF33">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02375">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21323">
        <property type="entry name" value="KDM5_C-hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02928">
        <property type="entry name" value="zf-C5HC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00545">
        <property type="entry name" value="JmjN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51183">
        <property type="entry name" value="JMJN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="56"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="334"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="960"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1624"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="960"/>
            <end position="969"/>
        </location>
    </feature>
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        <location>
            <begin position="1636"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1662"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1709"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1723"/>
            <end position="1734"/>
        </location>
    </feature>
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        <location>
            <begin position="1736"/>
            <end position="1745"/>
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        <location>
            <begin position="1756"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1785"/>
            <end position="1802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU63261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1892" mass="212187" checksum="20BC09AF8323BA3B" modified="2019-07-31" version="1">MHGSPSPRGAAARRGRSPRTHPNSPAPPVLPPDFSIRSPATFTSCLTIAVEGAIPIERPEPAAPSAADAPAPTDSSNKRAPRKSKTDALAALHSHAQSNSGEENLGDAMTEDGGIRIQLRDGPPLPVAPTLDLSSVKTPNTRPTVPKSTPRPFGLTDCPTFHPTPEQFKDPMAYIASISDTGKKYGMCKIVPPMGWNMPFVTDTERFRFKTRLQRLNSIEASSRAKVNFLEQLYRFHKQQGNPRVSVPTINHKPLDLWLLRKEVHKLGGFDAVTRDKKWADLGRLLGYTGIPGLATQIRNSYNRVILPYEQFCERVRNSPALSPVKARDAALKTHTNIQTSSTLPQLSTSDSTVGDDSPPPSPLTATSSPLSEPPDENDLKETNGVKADASRPRRSTRNTAPDQLPFARTRLTSTANDISTAGQDPDAPKEKRHPAELHCEICLKKDHGEQMLICDGCDCGFHMFCLDPPLANIPRGQWFCHSCLFGTGGDFGFDEGQEHSLSSFQARDREFRRLWFLSHGPQSGSLNVSDASSSARANDPYANRFGNTVVTEDDVELEFWRLVQTPTETVEVEYGADVHSTTHGSGMPTLETHPLDPYSKDPWNLNNIPILPQSLLRYIKSDISGMTVPWTYVGMIFSTFCWHNEDHYTYSINYMHWGETKTWYSIPGSSAEKFEAAIKKEAPDLFEAQPDLLFQLVTLMNPQRLKEAGVEVHACNQRAGEFVVTFPKAYHAGFNHGLNFNEAVNFALPEWLPLGLDCVKRYQEHRKMPVFSHDELLITITQQSHSIQTAMWLNDSLQEMTDREMDARTRARSLQMGEVLEETDRGDDQYQCATCKVFCYLSQITCPCTSKIVCIDHVDQLCKCPLANHVLRKRFSDTELQDIQAKVSERAAIPGMWRNKLKKLLDESPCPPLKSLKAIFTEGERIQYPLAELNSLRKCVNKANEWLEAANAIIIRKPTRKRTRKSRGRSSTVNGDGPSSDAAEEIIDKPERSLDDLYALLSEVANLGFDAPEIAQLRNIAQEAEETRKKARLLLDMERSARDREAFVHDCRRLILQSATLNVTVDEIVEVDKIVLREQLLKDLDVELEDDNLTLEDVRQLVGRADACSLPMEHSQMQRLQALYQAGTTWEDRAQRLLEKSDRTLEELEEFMKPRLSGLPVDPELLERIIDLRKKGREYEKQAKIWLLADARAEKPKVQDVVKLVADAQRDFAIPAVQDLQRTVAWAQDLETRSEAVLNATYSGVDEKDIFETMQTWRDYAKKHLTMFSLTNFSKLESQLESHNRWIQSLPWYCKSHNDTHGQPILDDVVEATRPEDDLPPSDEYFTCICTTPVRPPALGQVSDAVQCDHCFARFHGVCAANGGSCPFCDHHHWNGTIHKERNWHFCYLPTILMHAPDITKHYSEEWKQLEIIVHRVDRLCGVIGQFVSFLGQPANQRAEYIPQVRHYMRKLYKIQFAVSPNPEVSFGLDLASLHRVLAGQPVPVRMKKRRRPKFVFGQDQDKDWLDGTRCICRGRTNYLLNYPTVECELCGKLYHGGCVFFPVEAGRGARFMCPLCCVRKNRVYPYSEVRVKHVVDNPDPELFVDTKEMLDTFSKDIIYMRLPPPYTQTLFVDLLRFTPGQPDNVAANGPPISAPSTRSLPGSSNGPSIPVTNGSSAHPRSMHPPHSHHHHHHHHHHAISAPPPPAPPYENGRPSSSSHVPPPPPWAATSRWSSAAAAAAPPGPSRAIPPPTEQLRSPITGMQTPPLAPRKRKYPDDIPQHGPPPDDRLAPAPIIRSPKRLHSTVSTPQPSASRSGQGMSPSLAMMLSPTPGADMRSPTRQPPPTYSRSIPPSPGGRSGPTEDPHYASRQQKMKLAYPGQHPIPRAEDERWASQMAHETRSPQIPPPPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8M1</accession>
    <name>A0A4Q9Q8M1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_916006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8M1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8M1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="704" mass="75328" checksum="1D4AF5A249D20399" modified="2019-07-31" version="1">MASTALKQASAVPPTLQESQTNALLTLLNLNNPVEPSSNPIQPAGKGTATLKVASPAGPPVWKVLVLDQYTKDVLATVLRVQDLRDVGVTLHVQLHSNRPPLPDVPAVYFVSPNLTNVRRIAQDLEKGLYESYHLNFVEPLPRALLEELAAAVARDGTGELVEQVLDQYLSFISPSPSLFSLLPPADAASPSAPNAVAGPSTSSQPHSSYALLNSPSSTEQQIEEEIERVASGIFSVVVTMGHVPIIRAPRGNAAEMVAKKLEQKIRDAILSSARSHTPSLFAQDASGLSNLQRPLLLILDRNVDLVPILSHGWTYQALASDCLEMKLNRVVISKPQKRSYDLDSKDFFWAKNAANPFPQVAEDIDTELNKYKQDAAEITRSTGVSDVNDIAQMDLSANAAHLKTAITALPELTARKAVLDTHMNIATALLEEIKKRGLDELFSTEEAIGKQTAQAILEALRHPKNGATPTPTDKLRLVLVWYLSAPDSAITKEDVAELEKELKAAGADVAAFDYVRRTREISKMMAPSALGGASTPVPGNTTPGGELFKGFSALGNRLTDRLKDGGLENLISGVKNFLPANKLLPVTRLTEALMDPSAASNQSLQETDDYIFLDPRASRNPNAGLGISGVGAPGPGGAGSGRARRMAFSEGIVFVVGGAGYVEYGNLEEWAKRTGKRVTYGGTEIVDPGGFVQVLETLGKASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8T3</accession>
    <name>A0A4Q9Q8T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_809818</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8T3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8T3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="561" mass="61639" checksum="D20634AA1FEAE6B1" modified="2019-07-31" version="1">MGRPHRSRKSADAATVHRLNESRRALLHEIDNAKFSWFHVKIAFVSGAGFFTDAYDIFAITIVSIILGYLYGSVDPAPGPSLDSASHRTLSPTKQDLGIKIATPAGVLVGQLLFGWLGDVLGRKRIYGIELLVIMVATFGQALCAPAMAIDFLNVLIFWRFVMGIGIGGDYPISAVISSEFSSVHIRGRVMAAVFANQGWGQLSATLFSFIIVAAYKHSFLNDPPADVFRSLDQVWRLIIGLGCVPAAIAIYFRLTIPETPRFTMDIERNIRQARNDVDVLLSQDETYTVDHDAIDQRVQARKATRSDFTTYFSKWENLKVLIGTSYSWFALDVAFYGLGLNSSIILSAIGFGSQSNSSMPGAEIIYNALRNLTLGNLILSVAGLVPGYWVTFLLIDRWGRKPIQFMGFSVLTILFLVMGLAYDKLKSSSGGKIAFVVLYCLANFFENFGPNTTTFIVPGEVFPTRYRATAHGISAASGKFGAVIAQVAFQWLKDVGGPTGSNKFLGHILEIFAFFMLTGILSTMLIPETKQQTLEVLSNESQDEFIQGLRLTNVSIPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q939</accession>
    <name>A0A4Q9Q939_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_945116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q939"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q939"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23045" checksum="EA60D468159AF252" modified="2019-07-31" version="1">MAQVVMDTKGQNNDPLNYHEAMYKLIRRISSGFFPRPDRPWSEDATSTAPQIGRKRRLSTPEPEEEREQTPVSKKHRAESEADVTPAPATPEEQPQEKETEEVKEVTKGVKEVELEEKPAQPETSAAEEKEVLTDGKEAEADAEQAAAVPLPDSPLLKAAQSEDADAEGEVDAEGGEQAEETPATVEDADEEVPGLSLGSSSPEKAETTEGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAP0</accession>
    <name>A0A4Q9QAP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Peroxin-10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD310DRAFT_865838</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAP0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16527">
        <property type="entry name" value="RING-HC_PEX10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025654">
        <property type="entry name" value="PEX2/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23350:SF0">
        <property type="entry name" value="PEROXISOME BIOGENESIS FACTOR 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="20">
        <location>
            <begin position="270"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00041230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU64669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="322" mass="36280" checksum="CAB0364803B9B083" modified="2019-07-31" version="1">MSGNPPTFPQAQQAQIIRSNQRDLFQVFALREQAENVLRSWLGTRWLTRWDKEIDFAANALYYGLTIGLGSQTLGEEYTDIWLHSSHERRRLSPRLRAALILLPTLPSYLLSRWGSSLSQTSLVGATLRKVPTVMEVLSEINLAIFYLRGTYYSIVKRLLGIKYISTVPENPDARPPSYALLGILLGVRLLHRALSYLRSRSPKAELGDEKGKRIVDGDDDIFIDDRRVANMLEAAAHLEDAPPLPAEEDERTILDVSKIPPDVRAGRNCTLCLEERTASCATDCGHLFCWNCIVGWGREKAECPLCRQSLNLTSLLPVYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAT6</accession>
    <name>A0A4Q9QAT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAT6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12319" checksum="35F84B6E923991ED" modified="2019-07-31" version="1">MPRDVAAAPRGVHSLVVALRSTLAVAARQSHWFGIWYRGYVQVVRTSPISPRAFGRGRWLVGDCSRAGRVEAVMYARLFVEVSGRPMSVGITEKRKARVHWVPALLYKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB24</accession>
    <name>A0A4Q9QB24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pH-response regulator protein palC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_914465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB24"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB24"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071467">
        <property type="term" value="P:cellular response to pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09245">
        <property type="entry name" value="BRO1_UmRIM23-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037505">
        <property type="entry name" value="pH-resp_palC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40463:SF1">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="472"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="495" mass="53799" checksum="E1F97F2116A72329" modified="2019-07-31" version="1">MTSYLYELPTTGAISFADACLDSTATYTADIADTTEARANLRATLKESKRTDNSEKDYLKLVKVLDEYIPKLYGLLSCINSGEISLKAEPIFSWRTTLSSTLFHNSPRLSLPTFSTELIFALLTYAFSISNLARAVVHSLGRYETERAISDNERKAKDERLAFAVTLLCKAAGVYEYVGKECIAEWDRERARVTSLGMSCPRPPDISREVVIGLSKMALADAQTLAIRKLLSKAAFESTLTPGPPLPKSHPSPALVAKLHLECASLYSSARALVKTPGASKSSSKSKLKISLGRDKDKDKNANADDETGEEVAPELRRYLADEIAFHAALARKWLGVDAGEHGGTSKGGIAVGFLSWAKRELEELKSGHSSGGMISGEREKEIRERRKARVQEELESTGTFLVGYKKMNDSISFQPVPPQSDLQAMIPAGLLAVVVKPYTKPTPAFGPGSVEYIRRQAEELELLEAQSNGEGSPASPATPSSGPTKSYAGAEAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBZ9</accession>
    <name>A0A4Q9QBZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBZ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7607" checksum="DC923D39F6E8D7FE" modified="2019-07-31" version="1">MYSVVQGRLSNFSAIIFPTPDRPGNAAAVRILSREDLSAHLHLEALPTSLPDNVYDFGALTLLVGNTSHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD44</accession>
    <name>A0A4Q9QD44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_902742</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD44"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="562"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="813"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="67"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="96"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU65116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="834" mass="91372" checksum="9C2092D6F39E0670" modified="2019-07-31" version="1">MVRQQTLGKFFGKGGDPPVQTTLDNAFGGKRKRSTKAEKEEDAVDAKGGVGDFEKVVAATRSPSPAKHPKPKPPASKKRRVIQSDDEDDSGPGPSNTKQTRAGSQKPPSSNTTAKPNSVPSAPSKSVPNAKANKVAAVAEPIDEDDAAVSSTVEEDPDEGEEEVDADEDLEEEEEGGVASQNAEAALLKIEEVDLPNGWNVAEPVPYAALAKVFSLIEATTKRIEKTSLLTSFLLLVIRRRAEGDTQSLLQAVYLCINRLCPDYMGIELGIGESLLVKAISESTGRSLATVKAELKKEGDLGLVAMNSKNSQKTLFKPKPLTLPTVFKNLKEIAMSSGHSSQNKKVSIITKLLASCQGQEAKYIVRSLEGKLRIGNAERTVLVALAHAAVLAEQESANKRLNTEKLAARLEEAAGIIKQVYSELPNYDLVIPALLNAGIDGLKEKCKLSPGVPLKPMLAKPTKAIGEVLDKFEGKKFTCEYKYDGERAQVHKLADGTIAVFSRNSEDMSKKYPDLMEQLPRCVKEGTETFVFDAEAVAIDKDTAKLLPFQELSRRKRKDVKVEDIKVRVCLFAFDLLYLNGEPLLQKDFAERRALLQEHFQPVEHEFQFAKASDAETVDEIQTFLEESVKDGCEGLMVKMLEGEFSHYQPSRRTVNWLKLKKDYLAGVGDSLDLVVVGGYYGKGKRTNVYGAFLLACYDADAEEYQTICKIGTGFSDEALQAHYETLKPLEVHAPRGDIKIGGAKPDVWFEPKVVWEVLTADLSLSPIYTAAQGLVEERGISLRFPRFIKVREDKEADDATGPEQIAEMYQRQALAQTKGGKKSKGGDGDDGFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDX8</accession>
    <name>A0A4Q9QDX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_38579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDX8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU66032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19183" checksum="A9C62D8408837119" modified="2019-07-31" version="1">MSSRPNLASNQKVRFTLPITPLFILDSFLAIVIPSFIPVCGHHLLASDLVCIPSTHLLIGVVCAHDAYTLAHYAPTYIASAIGLTILTTLRISVAIPAIPMPVWYICKVVAAPVGCFAMRLLVAADPELGIVDSPSLLDPASMLVAALVGQGVVWIVVRLICTASFWQAINGCGGPGRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFX2</accession>
    <name>A0A4Q9QFX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RlpA-like double-psi beta-barrel-protein domain-containing protein-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_971868</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="5 6">CBS 464.89</strain>
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    <sequence length="329" mass="34106" checksum="48AFE5CA8616FD49" modified="2019-07-31" version="1">MHFFTLASVALTAVAGASAIVIPHRHAHVARQTPPSTYAEGYLEDYKVYHARYMALDCEAQHNTTFFDKCCHPLLATETLAKNRAPECNPANHVSSTASSAAPTQSQVLSSGGNDGDDGDDCDDDEPTSTVSSAAPTSTDDEGDDCDDDEPTSTVTPSSSHVATSTAHSSTIHSSSAHSVTLSSTHVATTSSHSSSTPVTTHATTKASSTKTSAAAPTSTGSSSGDFTGGHATFFYQGGNAGACGQVHPDSAFIAALQTKRYGDLSQESSNCGRKITATNTNNGKSVTVTVADACPTCPEENDLDLSFAAFTSIATEEEGEVPIVWHFD</sequence>
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        <source>
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</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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            <strain evidence="7 8">CBS 464.89</strain>
        </source>
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</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <location>
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        </location>
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        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU55568.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="796" mass="79465" checksum="F8E225DCBC8E81D9" modified="2019-07-31" version="1">MVFSKSQAALVVLSVLASSQQAFARMKWLERDDRPVVLNPRRFGQEHPAVIDKIGAACPGQVCGVLSGQAITPLLAAQPECSQQDMADAIIDAAQQFDDTTKANLIALAVEYRQVEKNTPPDFTTNPPTNRNSVFCQKAPKNAELNGLVQAQDPANDPNVFFDPATKQSVQKGAQPNTFPFGTAGSDDSDATGSASSAAATSTSSSAAAATSSAVLIATDSATSDAASATSSSDCETVVTVTVTSSATDAASATASSSAAAASSTAAAGDIGNFGSCSVPQITFAVGLDNRKETAFEPTDLKSFNHGSAQNIDIITQFICDTLTNSCKADQTAKDTCAKAKAAADTGAPKTGVQADLFNAVFGITTNFADVTAIDDQGNPIAGTGSSAASGSSTATTSSAVAAASSTAAAGGIGNFGSCSVPQITFAVGLDNRKETAFEPTDLKSFNHGSAQNIDIITQFICDTLTNSCKADQTAKDTCAKAKAAADTGAPKTGVQADLFNAVFGITTNFAAVTAIDDQGNPIAGTGSSGNQAAATGGSGATASSSAAAASSTAAAGGIGNFGSCSVPQITFAVGLDGRKETAFEPTDLKSFNHGSAQNIDIITQFICDTLTNSCKADQTAKDTCAKAKAAADTGAPKTGVQADLFNAVFGITTNFANTPAVDDQGNVIAGSTGSGSVAASSTAAAASTTAAATTTSSSAAAATTTAAAASGQNLQKFTGNLGGVTPPAVTKLSNGQFQVDGNSAFQNLTNALVRSCDVQHNKCANAANASGNKGDLTVSACGDQQTQCNAAAQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7E7</accession>
    <name>A0A4V2K7E7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_778468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7E7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020269953" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12328" checksum="074CF9E427724388" modified="2019-07-31" version="1" fragment="single">MKAIGRWLMLCFLSSSGRFPVRTSFVPLVRINTRHTLFRFCPCRPPPSSILPVPPSPLPRHAEYGQHHPRPHPPSLDSFVWRVFPVVGLRRYVLGRWRQSAHSTHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7W6</accession>
    <name>A0A4V2K7W6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_880498</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7W6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="27"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="191"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="362" mass="41778" checksum="9E735DB7CCF4A329" modified="2019-07-31" version="1">MPATTVPPVPHYEPAPETKEEFDYADVPIIDFSKVHTPEGRAELMPQVRDAMHTYGFMRVVNHGLSQAQNDRIIDIADVPFTQVSEEEQRQLVAKVREGDWKGYKPRQYWHIDNGVRDQIEHCGVIRPAFGQQHPKALQPFLPEVRAFMEFCHFDILHPILRLLALGLELPEETFVNQNHYDAEGMTFFRFMKYYPRTDEDEAQTKNVWLKGHTDSGVLTILWNQPVVSLQIMCPDGKWRYVKYIPNSIIINTGDTIEMLSGGYYKATIHRVVQPPVDQRDHTRLGVIYFAYGDDDVRVVPHKESPLLQRVGIKRKVPDENAPTIKQWRTIRISSYGNSETTKKEDGTEEQVLSGVLVKHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K867</accession>
    <name>A0A4V2K867_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_958607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K867"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="846"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="865" mass="94028" checksum="FD0E7A4715A81BF3" modified="2019-07-31" version="1">MEAEIEEAQRQIRRSAAIIQDTLQDLTTLQRMHNRAPEASLAARAPTDTSSLVTTPSANSVRSTEGAQEATRSTVIRSSPMDPGHDVIVISSETSTPAPSISFSTPAPPTPSSSTPSPASRGPRPLDSTLAVLGADLRSMTQSFRERVSEFDELRRAIAQYAQERHSRATERARSRSPPPDMTSLPPSLRLYEPEGSPPSSTNGTDAVPATGAPRRFNGRIRTLRGDSQSTLDRRSSLLRQRTTSDSETSLGLLVAARTASSNARNSVAETPTITPATISASARSVAVPSRPVATPAPSTSPSAANDRSEARHIPSNITSRITRLAQEIQQEGVRITQQAESLRSWINDRNARLDALRLPSPSSTIATRTILGLEPERPMTQRVPSPMIIGTPYLADLSTPTSENDPPSLLPWSQPAQRPRPSEPDPRPRDPPRDGALSLPRRAPETAVRARYLRQNVPTSWSATSPSSASPREDRVMAWNPPSREARERATDGPLSPPSRTIAPSGTQGGARGDGTATTRPTAFAVEFDEEVIARRNDIVRVRNERLRAQAEVDSEDDGELTESRSYRVRRRYNADGDEEVFRVELRPETFPGFGETSANRRAPPNEWEDDSGEEDSWMDALSRLDSMSRRSAAARDTRDRWEMPRMVRTGAQMGTVVPPTTLGPPTYPVNMARRSTRGWPRLYADEDISADSETQYERDLSAMRARAQALISAHAPARALGGTTLPPPPPPATRPPSFVPTTQAPGSLWNDSSVRVRLRTTAAHSNSEAAFVRGALDAARPAGRDRNGNGGGARAARDLASATSNSRAERPTWGSPVPFFPSALPLPLVEEVGSLQVRSRVFSSAKKDLARMPRRRLAAQVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8F6</accession>
    <name>A0A4V2K8F6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924353</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8F6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020985288" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="81" mass="9252" checksum="1FB3B2031FE94F09" modified="2019-07-31" version="1">MILTVALSSLLPRLYTLTGSRVICPCCSPIPLLQDTTVRFPLSSIVLRWIVDTRLDTCQRFDNLCFPRSLSDRVKRTKEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9L5</accession>
    <name>A0A4V2K9L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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                <person name="Pangilinan J."/>
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                <person name="Ahrendt S."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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    </evidence>
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</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15310" checksum="D37424D791D415A2" modified="2019-07-31" version="1" fragment="single">SLDSEWIATGSDVNAIILWDANGRVCHERVAHGGRVNSLAFSPDNQHLASTGEDYQVAVLNLGQGHSLLFRGHTDQLEAIAFNPDSTRLATASNDHTVRVWDVQTGASHVVLQQHLKGVEDATFSPDGKLLLSASSDKTIKI</sequence>
</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
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        </location>
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        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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    </protein>
    <gene>
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        <name evidence="1" type="ORF">BD311DRAFT_672939</name>
    </gene>
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        <lineage>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143492">
        <property type="protein sequence ID" value="TBU23908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MC85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU23908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6453" checksum="6DD38C9855BC1A41" modified="2019-07-31" version="1">MGKCANTDFQDLPIWDRWRRTEHARYGISPPFALSSCASPLERGEMDCTSVTTRPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MGU0</accession>
    <name>A0A4Q9MGU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928894</name>
        <name evidence="1" type="ORF">BD311DRAFT_699672</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143455">
        <property type="protein sequence ID" value="TBU25788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MGU0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU25788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9159" checksum="76BB447011B8E8F2" modified="2019-07-31" version="1">MITGFSMLDRLTSRTSTLAVEAFTTLEGVTLKNREKLGCDGLLRVLTWPVPAWVHTRAPGYGFRSGNPCMVYQVAAWLSVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MM44</accession>
    <name>A0A4Q9MM44_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_811453</name>
        <name evidence="6" type="ORF">BD311DRAFT_665923</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143435">
        <property type="protein sequence ID" value="TBU27211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MM44"/>
    <dbReference type="STRING" id="114155.A0A4Q9MM44"/>
    <dbReference type="OMA" id="NTQKKML"/>
    <dbReference type="OrthoDB" id="162638at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.410.60:FF:000001">
        <property type="entry name" value="50S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_bL35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_bL35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_bL35-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_bL35_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL35M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="L35p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU27211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9359" checksum="058591CD61146506" modified="2019-07-31" version="1">MLARVLGTARLFSTSAVAQFPKLKSHSGAKKRWRSIASGIFKRGKAGHKHLNVNKSPARKNALGQTAYSNPSQTSRLKKLLPYGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NC02</accession>
    <name>A0A4Q9NC02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_922943</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NC02"/>
    <dbReference type="STRING" id="114155.A0A4Q9NC02"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="255"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU60422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="775" mass="85462" checksum="B91F750CCF9FFFB6" modified="2019-07-31" version="1">MTMTARAAGIKRKTKPSASSLAKRVKTKHVLTDDLPWKKVSKPREADLGTGMDGFLDLEEVQDVDVVFEETEAGRVVKFKVRGEDDEGEDVLDAHVSEGEEVAGQSSAVTTENIDLDALPEPIKFDTKSLLPEWHSFKLHPQLARALYAKKLTTPTPIQAQTLPLALKNKDVVGVAETGSGKTLAYGLPILHYLLTEAYSRPIPSNKTRRPVRALVLAPTRELALQVSSHLNACLSSMDVDAVENKTGDDEVSKKGKNKGKAKAKAKAAETPALENKPKHPPLVSVAAVVGGMSAQKQRRIISRGVDVLVATPGRLWDILQEDDELATQIEFLRFLVLDEADRMIETGHFAELDNILRLTLRKSDDDVIGPENKMDEEEDTKDGVRGGDLQTFVFSATLSKDLQQNLKRRARPKPRRKADKPASTLDDLLLRLDFRDPSPAVVDIAPASRVPAALTESRVDCLAADKDAYLYYFLLRYPGRTLVFLSAIDGIRRLLPLLALLGVPAFPLHSQLEQRQRLKNLDRFASTRNAVLLATDVAARGLDITGVDHVVHYQAPRTADAYVHRNGRTARAMRRGFALLMCAPDERRVVRALMRGLGREEEELAEMPVELYMLDKLKARVQLAREIDRLQHKAKKERHERSWLKEAAEAMEIELDSDLASDSDEDKAPSKQKQKAAGAKAAALKAQLKAMLTQPLVARGVSTRYITSGVRSIADDLLAGEYHETMVGMKKVEAGSDLVPAKARKAKKRATKAEEEEFEEWGGISVGAGGSDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDJ0</accession>
    <name>A0A4Q9NDJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_992952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDJ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NDJ0"/>
    <dbReference type="OMA" id="MSSINCF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU53331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="362" mass="38743" checksum="9688CD37F03A96B9" modified="2019-07-31" version="1">MAANDSARLYAAETQVAIAAVRRACVLTASVFNKLVKQETLTKDDKSPVTVGDFSAQAVINTILGRTFPDDPIVGEEDAADLRVDSGKALRDRIVQLANETLTAELRPGEKEEWGLGPNHARTADQLLDAIDRGNYDGGPTGRIWTLDPIDGTKGFLRGEQYAVCLALLVDARVELGVIGCPNLPVTASNPFSTRGCIFFAVRGQGAYQLPLDNAFGGERTKLAIPSSTPETLNFLESVEKAHSKLSFNERVGEILGVTRAPTRMDSQAKYCALARGDGGVYLRMPVGSGYKEKIWDHAAGSILIEEAGGVISDGRGEPLDFGLGRLLGENYGIVASGKDVHEKVIAAIKQAKAEEEAQSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NF78</accession>
    <name>A0A4Q9NF78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_818416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NF78"/>
    <dbReference type="OMA" id="MSGHDSQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="438" mass="46743" checksum="7CFDA3C7374D00C6" modified="2019-07-31" version="1">MSGHDSQSGATQWTEPPWSGWIETTGDALLILEAARRGLIPRVTRRLVDSERKMITSGSVFVFDEDESGIKRWTDGFFWSPSRILGNFLLYRETEKRGAGHRSARAEAAATVEEPDGVKQEGQTLSRPKSEASRLGIDRQRERILVGSLTNSYKFKPGGLMKKTFSLTIGGVAQHLISYYKIEDVEQGRLRSPSSLPELASLTISPEYLDKTHFRNPPKVEIGVDGIPRYRGEADDVDLSPRLLPAPLSNGYYADGDAGGSKRAKRYEPYGSTGSNPPKRSRKKNNSASSQSEATGGESPTQPMASVHQPAPGYPDPSVSSHYAPYGGYYQAPPPPAYPLPYSPAPYPAGLPAAAAATTPPQERYAYYPPPPPHGYAAYSAMPPWPHYNGSYAQAAASSATTGSGTSMQEIGESDVRNSAGGGTGTVAGGGTGGGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHR3</accession>
    <name>A0A4Q9NHR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">O-acetylhomoserine ami</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_940754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145261">
        <property type="protein sequence ID" value="TBU52215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHR3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHR3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU52215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="439" mass="47239" checksum="7026F572E41EA3B4" modified="2019-07-31" version="1">MIPPKPENPFYREPEFETIQLHAGYEPDAAQRARAPPIYASTSFVFKDSQHGADLFGLRTTGNIYGRMGNPTVAVFERRMAAMEGGIAAVATASGHAAQFMAIAAIARAGDNIVTSSYLYGGTYNQFKVFMRKFDITMKFVESEDPAAFAAQIDDKTKGIYVESIGNPKNTVAPLPELAKLAHDNGIPLLVDNTFGMGGYLVRPFDHGADIITHSATKWIGGHGTVLGGVVIDGGKFDWAASGKFPEFTQPADGYHGMVFTERFGDAVFAVKCRLDVMRDLGPCMDPFPAFLLLLGCETLSLRAQRHADNALALARWLETHPKVAWVSYLGLASHPSHTQALRLLRPGAFGGMLNFGIRGGNPQVGAAVVDAMKLASNLANVGDAKTLVIHSATTTHQQLSAEEQLQSGVTPDLIRVSVGIENIADIIADFDHALQLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJ21</accession>
    <name>A0A4Q9NJ21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_828707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJ21"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJ21"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="619" mass="70524" checksum="127B38D519282898" modified="2019-07-31" version="1">MSRLITTYYLLDISANGYVPKTWEPRELWPQRFAYTTFRDALEFERLRFLFPCWRPHLDNHAFWNKAVAVLDPMGTYNHLTVVQPTPTTGSNAVLIGRMSMWQHYRHMLDASCIVCRVNFPYNGEGLCTGAGKRSSQTLIHGQINLCKEHRKGTAFCGVCLREAPRLELEEDYAQGMPVCCVENEDEETWPKIEATCRGCRTEAFWKRVNMRPEWQVAVDQRRWPMLDWETRQSVESFIDLGEGSIRDVLQVAEEKHWLRSYTKIGDMLQQALAASKFASRVDAGEAYGSDEEVSDDEMEDPEMLSLTEDAGGIRELAINDWVRNRILDGHWISPADDYFNHMNYGRPRLAPARHPCPWNRRAVYEGALDDGQQGCDGLEELTHPRPKTHLVPHPPTYPLAQQIYVAFQRQMREILLPPMRNVVRKLMMEASADGGDAGMRAHNMTVEDVVNELRDESAWYSGVDWLEVRQNRIEEEDRRRREREKDEDDSSSSSHSGGSHTTSPVLSTTTLQTTPSPPPVNKDEEAIVSSPLAGVPPPAPFAHLQTSSLRAAELLRPIPYVPVTTDHMAHYSREAFSLVRILGISEKRDVVLTAYLCRCGRRHARRYGTASALSASEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNA5</accession>
    <name>A0A4Q9NNA5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="1">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCKDHA family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="1"/>
    <dbReference type="EMBL" id="ML145238">
        <property type="protein sequence ID" value="TBU52759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNA5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNA5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000055">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0786">Thiamine pyrophosphate</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="452" mass="50351" checksum="EE5D9DEF93914C61" modified="2019-07-31" version="1">MFRPARIPRLSQALVSRVSRVSHARGVAGTTPQLPQHALGSLPTSTSPITSKLHFFNSVMSGEKKIPTYRVIDGAGQPIEGAEVPEIDKALALKMYEHMVLLPIMDETLYNLQRQGRISFYITSFGEEAAVIGSGAALAPDDEVLAQYRESGALLFRGFTLDDIMNQCFGTYLDSSGKGKQMPAHYGSKKLHWHTISSPLATQIPQAAGVGYAIKRDPNRRGKNCAVVYFGEGAASEGDFHAGLALASTIPTPTLFIARNNGFAISTPSTEQFYGDGIASRGPGYGVHTIRVDGNDVLAVFAAVKEARRRCIDEGRAVLVETMTYRVGHHSTSDDSFAYRPRKEVEDRKRLDNPIVRFRLFLESRGWWSKEEETALVKRLRDEVNAAYKRAEKLPKPPVEEMFSEVYGGEMPWNLKEQREELKGLIKKYGQTWEPWKSELKKHKGEGKEFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSK1</accession>
    <name>A0A4Q9NSK1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1011271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSK1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NSK1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
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            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
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            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="615"/>
        </location>
    </feature>
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            <begin position="767"/>
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        </location>
    </feature>
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            <begin position="804"/>
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        </location>
    </feature>
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        <location>
            <begin position="922"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="1043"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1059"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1126" mass="121485" checksum="FE31E4A49BC1675C" modified="2019-07-31" version="1">MTPRSVQVSKSRPLSAIFLGSAGSTPPALPDLPEPPSPSTSSNASGLPSPPATNSTGSGSVGKGSTDAGSLRHRTPSSRPNSSDTSMSGGGVGDRSYDYRKKSSSFIEDEDDADENENDEDHTARLDERRRSLNKGADNASALQRVKSLTQRNRMVLDKLTSISRLNSPVPSNHSRSPRSPPTAGSTSSSSTSATSSRLSSSQNRPSSVTNSSVDGRRGDTQLSGSETERESQRHSTRSTSSDGRTTPPPSAFSIPEIRGASSIRQRRISAPASPGKARAAARDKDRESPGPSRTPRKRVSVAHSVDESYGHYRSDDEDVTAAALAAVASSRRSPTGGKKGRQLLPREFRDRKLSDEKVTSNEPATPRRSSSRAELGRASPSPRKTRISTSDPPGSPRRLGQARYSTVRELTRKHQLRWMSEDLSSPSREQPDQSFDGPGRRQGHRTGSSEGLLGTAGGRSLIGEGLRAAGLTKRRDEDVFTSPNGHVPAPMAAQRTRSSGDSSIISSSEGDSSYGRSLEGDARVEEGVGPPYNPKTPMHASLRVRPLSGTAARPGTSMAALHHDDPAPPRTAPPALRTYKSTYALPDRNLEEFKRQPLDRSSPFGTIRSSTVQSGLREASTDHRRLMLEALTMFESQLSRLPPMGQTSTSTIPEVFQSAQQLVHTLDKLNAMLKEGTNKALEAQIDAELADYKDGVDLPELWREVGSDHRENLRVSDEVVRNMTGFLLGVGKILRETTSSSQHLRTMSLDEEVARRLTPEVQLNGRGRDSDGRRSREARRSWEPGKDTGRLVARLSSLERNGRTGSRPPSSMNMLRSSTATSSSEGRSVAEANDGTPATVRQAAPVSAPTTAARRLYTPRERLDTTTTAFSPGQVDSPADYEPSPTPISRQSHVSFPDRRALPPLAVPPSLPTLPSESLIARSNTASTTAADKLSRRKISASSIVTIRPESSPFTPSIKPPNPTTAVTTATVSTSYDANPPPFPMLRSESGSSSRTNGVTFSRATATSVSSTLSGLQQQHERGARNRKVSYNSMFTNPTPAPVLAPAAPISSSQSGSESERERDRDRDRDSRARTISTRPRASLEGSRADERPVDAVRRSLATTVSYSAQRKERRRTITEIFSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NT47</accession>
    <name>A0A4Q9NT47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_855571</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU56106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NT47"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
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        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF19086">
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    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
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    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="387" mass="43590" checksum="C1E4ED97DB5A9C5A" modified="2019-07-31" version="1">MLSRIAGMNVVVCQSTTASPSWKAERSMNIPDTMADWPWQRAFHPYTDEATLESDKWFRSLAIFSPKSMHAHEQNFVGCLAGLAYPHGSPNDLRAGMDFMHVLFAIDEYAEIERPAAVAEFVQILLDAFHNPGKPRPSGEITIGELTRQFWARAGRTATPQAGKYFLEAMKDFLDSLVSQAEYRNNGTNPSIDDYIQLRKNTVGARPAYIIGHLCLSIPDEALYHPAIRELEYLAAELLALDNDLASYNREQATGNDQHNIVTTVMRHLKLDLDAAVDWTASYHKQVERRFLDTLERVPSFGPAVDADLKRYITQIANFPRANYCWIFESGRYFGSHGAEYQRTRRVPLLPKRVQQQGAITSTADIDVPLIEDLERLAAIAAVEGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NT65</accession>
    <name>A0A4Q9NT65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_824703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU55981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NT65"/>
    <dbReference type="STRING" id="114155.A0A4Q9NT65"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="204" mass="22104" checksum="09982789BDB34F67" modified="2019-07-31" version="1" fragment="single">SDVRGVIIAEGDVLVLSIRLFSELLLGRYALPCPPSTDSPIARLAHAIMDKHAKGLAALPGGHRSADAEYYILPQAESAIIALGHAMAYAAARDSGRIPQPLLALYETSVMRAYSAWFSEDLGVPLAQQRQQETDALRAALPDLPRFARELGVSDYVRASILDDATWERSVRQMTTYVGTEQGSQYALGSVAVPEGIENVRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVJ8</accession>
    <name>A0A4Q9NVJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cwf21 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_840642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVJ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NVJ8"/>
    <dbReference type="OMA" id="GRSHYDG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="45609" checksum="D206B8060EBDBB17" modified="2019-07-31" version="1">MYNGIGLTTPRGSGTNGYVVRNLSTLRSYQGPQDRAGAWDVAPPKHREPDAEILEHERKRKVEVKCLELQLQLEEDGLDEAKIEEQVNELRTKLLAEASALVQNAKALKPSDTHGIAAAKKDELNKMARALGTRSDYHEGDAFDREKQEEQRLRRMAEREEREKQREEERAKMRAQKEKWEAERKERDRLRRREEDRRRKERDEGYSRRDRDTMPPPPLPPSRDRGGRDYRDRRSRSRSPRRGPSPDDDRDYRRRRSPSPPRRRGASRSPPSPPPRTRRRFESRSPSPPPRAKRSGSVEPPSRGERGLSQSPPPYPPRSPPRYGRDSRRRSPSRSPSRSRSPVRRDRSPPPRSRGMPATRSPSPPPAGDRGPRRRGRSSSSDSSMSVSSASSRSRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXV6</accession>
    <name>A0A4Q9NXV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_927915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXV6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXV6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="541" mass="57198" checksum="D1B3206018F02F2A" modified="2019-07-31" version="1">MDRLESLGNALSQITMYDIKSMVNQAKNVVFNVSEMEAKVRDATNDEPWGASSTLMQEIAQGTFNFQNFNEIMPAIYSRFMEKEARQWRQIYKALQLLEYLIKNGSERVVDDARSHIGTIKMLRNFYYVDEKGKDQGINVRNRSKELVDLLGDVEKIRTERRKAKANKHKYTGVGNDALSFNSGGGRYGGFGSDSFYSGGSYSGGGGSSYSGGDRDYDRYDAGESRTYGSSGSNARRGFQEYDAGDDDVVPRRSNSVAGTSSSVHASTPQRSSTLPPAPIEPPKAQPVIDLLGMDDDAFGSTVSAPPEKALPPTGSQPLQGGGDDDFDDFQSAPPSAAPTNNAFFNTVPAAAPTALPLPLSAQPLSPPATQTQVPAQNANNLFNLLSTGAPAGAARTPYTSPPAVQTQNMMRPLVASPPPLGGAPLIPNRPLQPTSPPPRATTTSPGFGGGAPQQQKPAASFDDLWNLSLSSSAASKPNAPAAPQKSMKDLEKEKAQATFWGAGQSKPPAAAGFGAFGGASASAAPPASSQSANGLDDLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZQ8</accession>
    <name>A0A4Q9NZQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_931201</name>
        <name evidence="10" type="ORF">BD311DRAFT_761257</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143437">
        <property type="protein sequence ID" value="TBU27049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZQ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZQ8"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU27049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU56573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19841" checksum="D22209FBBD5D2C14" modified="2019-07-31" version="1">MSLLRACQQAVSKQAFGRSAFAASRPYSTPTANDPTIPAAAPKQDTDIAEAPARDVVTADIVSGAPKELRHRAVRIFQPTRSTTQSGSGKSNQWRIDWDILPGGGRWENPLMGWASSADYMQGTRLNFKTKEDAIHFAEKQGWDYYVAQEEVNRIPPKNYAENFLYKPNKLRLIRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZS1</accession>
    <name>A0A4Q9NZS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_918176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZS1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZS1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="502"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="89"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="373"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="543"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="578"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="628" mass="67562" checksum="AC1F1AC33402DE21" modified="2019-07-31" version="1">MSSAHPSQYSSYSLHQPMQDSVRLPSIKDLNFPPPGQDGAPANGQGRAEHARARHEPSSWSRSSAPSAPIPPSQHSSGMPPPHDPPPKHQYAPPSKPDAPYAHSQAPPASQQPPAGVQPHHGVNAGASRPDSSSAEAQSKRSRSQQGVSASPVRSPHTVYPPYPAQAPPPGYHQGPPPQVAPPQEHIQHPSHYPPPGYAPYPQPQQMSRAHYAMPPPPAPAHHQNQPPASPYPPTEHWQHPSAPPPAPAQQPPPQQHFNGYARTTPLVPAPVEARAPPPLVSSPADAERANARHQVIAEIVKHCNVLYGFANHYANVTRQHPQAQPAPQEIEEMNYHASTVMRLLEDLRRLEGGEDTSRKDGDYPASTNPAEEQVRPPKRPWEDMAREGEPPSAIVHYDAQSTAEHDMQIIRNKRQSSTGGAAPGQQKNKYRKRSRATPPGKCHSCNIRETPEWRRGPDGARTLCNACGLHYAKLMRKREKTLDANGKAPPIDLQTLRASTASARGGGGEHGGEPSHSQSHPPPHQGQPPPSPYDQPKQLPIHAGAPAHPGPYQLMPVGAPGPSGGQPQQMMPPPHAPSSAPHSAAGGPVPPPPWLAHQNGERPGYNSEPQSYVRASHPPSHARASPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P0W5</accession>
    <name>A0A4Q9P0W5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_544785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P0W5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="37"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="389" mass="43023" checksum="F51BB4C3631A08A8" modified="2019-07-31" version="1">MTTKDRLPGLPEGVISRSLLVRDLDIHILEAGKRDAPLLLLLHGFPELAYSWRKVLVPLANLGYHVVAPDQRGYGCTKPYDASAPGATRLVRFEDDFRPYGMMNLARDVVALVYTLEHKSVAALIGHDFGSLLAGNCVIARPDLFERVVFMSAPYNGPSPTSSPAGTIASIMNLLKGAQPPRKHYITYFSGPTANADMLRAPQGLHDFLRAYIHAKSGDWAGSGASPQYIPMTSEGLATLPPYYIMPADETMAEVARKCAPSAEEVKTKSSKWLPESELGVYVSEYARAGFQGGLNWYRSLLSDELNDELSLFAGRRIEVPAMYIAGMQDWGTFQMPGALDKMQTQTCTKMDDGDVVRIEGAGHWVQQEKPERVVDEIARFLKKQRDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1E6</accession>
    <name>A0A4Q9P1E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_924993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1E6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12425" checksum="073043C6949A9314" modified="2019-07-31" version="1">MGPGGLELSYLIYRLHRVLRDEARRNAFRPEPQSLMATMPTSSSTDRFSMHHHLALGTGSPRRSRMSLGQYSEGFTHHEILIGISYSTTSALPRGPPLKLNVWVSPHIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P943</accession>
    <name>A0A4Q9P943_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_842453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P943"/>
    <dbReference type="OMA" id="GWLIMFQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF80">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="490" mass="53357" checksum="F303510738D17CF2" modified="2019-07-31" version="1">MGQVYNISLAIFCAIGSFLFGYDSGIISSVITLPAFKSFVNNPKNYDSLSGAVVSTFTGGCFFGAATAGWTNDKFGRIRTVQLGVIIALWGCAMQSGANNFACMLIGRIVAGFAIGVLSMTVPLYNTEIAPPKYRGFIVGLTQQMIGIGFIVANWVGYGCQFLKGNVQWRLPLGLQLAPAALLLLGSFFMPQSPRWLLEHDRDDEARRVVHTLHGSSASAQEEADVEFAEMRETIKAEVLVRSRSITDLWATRGMLRRTFVAVGVQVFGQFSGINVINYFGPSMYRALGLSAGQSLLVQGIYGAVGPITNFFFITLILDTVGRKKPLMFGAGSFVVTYSVLTAIVASFPPDESTNLAAQRAGIAMIFLTSIFFSLSFGPVSWVLASEVFPTRTRSIGTSVATCANWAFNVLFSQVSNIAITNISWRYYLVFIVLNAIDFIIIGLFFPETKGLTLEQMAELFGDEVDAHDVLQCAAAHEKLNHDHLETEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB90</accession>
    <name>A0A4Q9PB90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_833208</name>
        <name evidence="2" type="ORF">BD311DRAFT_758203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143421">
        <property type="protein sequence ID" value="TBU28440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145274">
        <property type="protein sequence ID" value="TBU51969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB90"/>
    <dbReference type="STRING" id="114155.A0A4Q9PB90"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08588">
        <property type="entry name" value="PI-PLCc_At5g67130_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597630" evidence="1">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU28440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="32766" checksum="F91946972CCE63E3" modified="2019-07-31" version="1">MRAASFLLSVAAAIASVKGAIVPQRRADVCNGHAELCNRSYGNVTFLGAHDSFAFSDDPLALAADQQVDIPTQLGLGVRLLQAQAHVNDGVLHFCHTSCLLFDGGTVEDYLNKVHDFLTANPNEVLTLLFTNPEGASLPDLWDPPFQASGIADLAYVPPSIPVKQSDWPTLGDLIDSGKRVIVFLDAGADTDRSVPYILPEFEMVWETPFSVTDATFPCSVDRINGPLSTEDHMYMINHSLNKNILDTGIIVSDPKDAPTTNSVSSILANAGGCEGFAAGRAPNFVLLDFVNLGQGLDAVNQLNGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBU8</accession>
    <name>A0A4Q9PBU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_971023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145272">
        <property type="protein sequence ID" value="TBU52008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBU8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBU8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="50"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17860" checksum="D3440BD42BD2827A" modified="2019-07-31" version="1">MSTESVPSKRARLEDAGEEVEGRSSAEASDKMVSAPEERSRDEEFWFEDGNIVLVAGAVEFRILKGILAEHSPVFKDMFSLPQPPETTTQGTQCPVVHLTDSSYDLRHVFRIYILKANLDPFAPMVLSFDELSASIRLGHKYQTTKLVEYFIAYLGECP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBW4</accession>
    <name>A0A4Q9PBW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_940602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBW4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9438" checksum="94920A09D8E606C1" modified="2019-07-31" version="1">MSRRQLEREHRPQFGRRLHSTSNQFSNPSSPRYVRIPGLLARSLHLLTLHQIRPRSSSHPMTVQSSASGQCTARIYVASVLAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC93</accession>
    <name>A0A4Q9PC93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_231334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145251">
        <property type="protein sequence ID" value="TBU52414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC93"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20200" checksum="E35FC25845600C0D" modified="2019-07-31" version="1">MVGSGRRAWGSQRRTRLAGEAARRAGRWIERARGGARSPSPSGRSPTALSSNRAMTSIATNRGRSGCSVWFAVCSVAMSPARELSRRPRAGCCLSVGTSTSPSLPAYPPVLDHVHAAAWISAGVVAWPLPRCAVADVGRVTPRSLRGASPHGRLLLLVNAVRYTPPCNRLLCRRLGARHFAGVRADRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDB3</accession>
    <name>A0A4Q9PDB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">G-protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_831336</name>
        <name evidence="8" type="ORF">BD311DRAFT_677146</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
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        <property type="project" value="UniProtKB-KW"/>
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    </dbReference>
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        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
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        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <begin position="414"/>
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        </location>
        <ligand>
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        </ligand>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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            <dbReference type="EMBL" id="TBU21954.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU52840.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="503" mass="56025" checksum="B397884C5AF54A32" modified="2019-07-31" version="1">MAAVATKAFWSQPDPDDPLSQALQPPPNESPEDRAARIRQQEDAIRVSKEIDDEIAIAKRAYERRKKAIKILLLGQAESGKSTTLKNFQLAFSPQHFHKERSAWKTIIQLNLIRNIKRLLEVLQEEWESSLQTTTPASIAKGKGVAGRTPTSPGVRFSTSPLTDNHRRIRMRLSALLPIEDELMKKLLPDGAAAVKDVCVRAGSGWKGILTALSANTSTLGPVTPAKPQLQLVSAMKGGSNPSSRPGTADAAKFKDNPTAVLAACKDDIVTLWEDPIVRGVLKKHNVRLQDMPGFFLNDAGRVAAMSYEPTDDDIVRARVRTLGVEEHHFTMESGALPGTEWYIYDVGGSRSVRQHWIPYFDDVQAIIFLAPLAFNLTLEEDPKVNRLEDSITLWREVCTNALLAKTTLILFLNKMDILQATLASGIRVVKYVPSYGDQPNDITHVTKYFRDKFRGYHKRLSPKARPFYWHETSVIDTRSTAAILVGVREGILRAHLQSVNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDY6</accession>
    <name>A0A4Q9PDY6_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_835079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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            <dbReference type="EMBL" id="TBU51171.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9613" checksum="FBA98303DA11DF4D" modified="2019-07-31" version="1">MLILYGILQCLTARITPFHTYAGYQYSRPCRAVRSKRTPVVWPGSMHPIYRISKIVASSKTDLKEDGLNDRTLTENTSADGPGIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE22</accession>
    <name>A0A4Q9PE22_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_952296</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
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            <begin position="103"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12499" checksum="9EB2B90F2BED57D0" modified="2019-07-31" version="1">MHRAEHVGTRHSALVHSRPYTLICRTNTVAPTPQKGSTRMQAVTHARAFVRRLHMQGQGKQAIELSARSRPYATASNPTHILTVLSPTTAIISRPTCPFSPDRPTTPQTNPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE81</accession>
    <name>A0A4Q9PE81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_168884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
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            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
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        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33230" checksum="6FAE4CCC88F87D70" modified="2019-07-31" version="1">MTIQVSTTPGSLATEQLRDFFDRLAAGDYHSLAKELHITGRPIQQPAAVLNNSHRDTDSGGSVDTQDPNASIQSIDSVDSFKFKPTADGLHRAVSLIRGDAPQQGAATPEEEDEAFEFTFRLMLHKLYSIKDFAKMVDDVVRSSRENYQPLSPALLSRGSGRRPSVSFAFACGEDAYGDGDSFAILGSPASPSEASSIFPSSDSSWTLDRVSSPPFEDESDARAVKKRIVGRKLSVVDGSMDEENHGPAWVYDSAVASVDSPVPRYESSFSRGRESPSGLDYPETVDGMGYGSRKRRFSFLAARAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEC1</accession>
    <name>A0A4Q9PEC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine-specific methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_168291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145220">
        <property type="protein sequence ID" value="TBU53254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEC1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEC1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="405" mass="44840" checksum="28D3DEA961864D5E" modified="2019-07-31" version="1">MTFDTSVDTVRILDIHPRSVPTPGSSIRDQVISGLMKPAGHKTLPNILLYDERGLHLYDELTSDAAEYYLFAAEKEILQSKAAEIVKAMQPGMHDGALVDGVIVELGAGALRKTSLILGALARLVPCPSPIPPISYYALDLEKRELERTLRGLGLSEVGTELQGKIATAGLWGTYNDGLQFITEGRLRDEDVGVGVSGDGIEGTEAIGPPTLSSQQPLHILFLGSSLGNFTREDAAGFLRSLPLRSSSHDTLLLGMDHGNDAQKIRMAYNDTNGVSRRFVMNGLRCAGRVLGEERLFDQEKWEYVGTYNEQLRRHEAYYKSGSDQTIIDPETKATFPFVKDELIRVAFSHKFSEQDTYTLFTEANLHPVHRWTDSSSQYSLWLLQRQIAPKVSKQSSSLTSRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEJ8</accession>
    <name>A0A4Q9PEJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_938663</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145223">
        <property type="protein sequence ID" value="TBU53148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEJ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEJ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="246"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="394"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="341"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="425"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="551" mass="59423" checksum="0E56E7327D096351" modified="2019-07-31" version="1">MSLKAELETWAAALQAYDQEDFEKSLELFSQIADSSKILTNIGLIYATLGEHEAAVEQFTAATELDQYLAVAYFQCGVSNFLLTRYDAAYNDFSSALLYLRGNQFINYEQLGLKFKLYSAEVLFNRGLTQIYMGNAQEGLADMEDARREKATEEHGVIDDAIQDRGEGYTVFSIPVGVLYRPAQKKLENSKARDFLGKAKLVAAESTNDLFTEFTGVVRLKQGVTPTNVFLEDGPTSNLSRAATVAAPSVSVPKPADGDDPKPNLQRAKTTINVPADARERIRAANVGGAGSAPVTPPKTSPTAPAGPSLTRSATSAGAGRGPSAPLGLNGPTRGLSIRKGGSPTGPTGSAPPRGGAGARMTEFYDDYLEGYTGEEANEVPPLPEARVANWAKGVGRGGRPSAPPSSYGGSLSGGGSMRRKLTRRGTAASRGPGSRAGSSFYGGYEEEEEGYVSGEYEDMFEMVKIRVKLHYREEVRGMALLPETPFEEFMEMVTRKFGVVPGALGMKFKDEDGGKVTLRDEMDYELAIETARHSAKGRPEGRLEIWCMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PET3</accession>
    <name>A0A4Q9PET3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_343024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145315">
        <property type="protein sequence ID" value="TBU51491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PET3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17665" checksum="0A015AFA5CCE468E" modified="2019-07-31" version="1">MRMCLMIVADDFHVHHVDLTALVQLLVLNSSDGAQAASHDLCSEPGQDDSARPVVGVRIGTRYTHIVFSVLGRALWDTGGSDSPGSDLYLVFSSVPSCVKSNILPSRPSGSFSAPLCFYDILQCCRVSRPGNTVGHPSRAGLRPTQDDPGTCSRRRLALYFWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF52</accession>
    <name>A0A4Q9PF52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_951991</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF52"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF52"/>
    <dbReference type="OMA" id="ISPPVWQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="18">
        <location>
            <begin position="30"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU53590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="423" mass="47065" checksum="42E55B0CC506EA08" modified="2019-07-31" version="1">MPAVTLENQNRKLGGYEFFEKALGSPKYIVAPMVDQSELAWRKLSRKYGAQLVYTPMINAKMYAEGSRKPYREQNFDTVHGEEGGPEDRPLIVQFCANNPSQLLTSAKLLEPYCDAVDINLGCPQDIARRGHYGSFLQDEWDLVHKLIHTLHENLSIPVTAKFRVFPTVEKTVEYAKMLESAGAQMLTCHGRIREQRGQRSGLADWEKIRAVKEAVSVPVVANGNILFHGDIEKCLSATGADAVMSAEGNLYNPAIFQPDPSAIEPVASTSSASQYLTGQHPRNTHLALEYLAIVKSQKTLTTPSAVKGHLFKLLRPALSKYTDIRERLGRVRVERADRDKEGGTAWDKYEEIIEELDERLERDIEAASDRTLEELSPIDPATGFPVLPHWLAQPYIRPLPAEPEAAKPPAQGKESGVEVVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFK7</accession>
    <name>A0A4Q9PFK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_831066</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145229">
        <property type="protein sequence ID" value="TBU52995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFK7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFK7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="38"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="194"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="382" mass="40738" checksum="A1D492A5397EDEB8" modified="2019-07-31" version="1">MATTDSPNGSGGYMRAAVRLPRAKRPLVQMVEKPAVLPKTVLLEVAAAGVCESDSRLSIKDGRDSFVMGHEIVGYAREIGESVTGIELGALYAVWEMVPCSKAVGASPLFLRHGLGVDGGFAPFVLVDTKRATLVRVPDSLVNKPELAALAVDSTALVYHAVTNVAKLQPFKGKGKSNSSEGEAPRVLVCGVGGLGHQALWLAKSYGATIFACDQYPPARQLAKNIGAERVFTFEELKHAAQNEKEKFTVDLVVDFVGSEASVKATKLALQPATADNNRGTLVIVRPRAALSGSVYDDLNRKYATHTVLECLAVDGLTHAFRLLAEGAIEPTLQRVALEDISGILDELEEGTLLGHRVVTNFEAPEAGPPSGEPQWLVHPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG50</accession>
    <name>A0A4Q9PG50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145262">
        <property type="protein sequence ID" value="TBU52187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG50"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13730" checksum="14E6EEDA0904C882" modified="2019-07-31" version="1">MTTGCILARSFTSPAHLPLPAQLAPPRPAFPLLFTPASAWLFLDTTSACFYKPVPLSVHPECKPPPTSSSGGGSVRFSCSIPHTMWTAKRSETNRPRALHTKVRYHLLRMESTQCALHVSAGAESTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGE3</accession>
    <name>A0A4Q9PGE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1043143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGE3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="328" mass="36188" checksum="A2B8AAE1AC836BF2" modified="2019-07-31" version="1">MSSRKPLVAVVGATGTTGASITKALLASGDFRVAVIVRPSSLSKSIVSEFRASGAEIRTGDVQDGIESLKKTLEGADILVSAVVAWSINEQRDLIRAAKEVQVQRVVPCDFGTPGAKGVRALHDEKLAIHDFIKELGVPYTFIDVGWWMQLYLPLPLRSRLPLPLKEMTWKIYGDGEARNLLTSNQNIGKYVARILADMRTLNHSVIVWEDEVSQAEAHALGERLSGEGDALKKKRIVATKEDYLSAAAAAKEVLAKDPSDSGAHMIESWNEYQVSMYVLRENTLENAKRLGYLDVRELYPNITPLPFEEYAKQFYAGEDPGDAWSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHF4</accession>
    <name>A0A4Q9PHF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_952272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145223">
        <property type="protein sequence ID" value="TBU53147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHF4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23171" checksum="BDEF6B1DD6FDB95D" modified="2019-07-31" version="1">MSLQAFEFERPTQRRSLSLVPSSIARCLLKHTVVSYDVAVGVFHRRASRTSCQHGGQASRVNRRDVHVYDVNACLANDDDLGYEMTNANPLSPSSSTSAVRAVFANASPAQLTRSRGTYYSTALRTRQVSPSGVRRGAAHQHVQSQQRSIRKRGRADLDYICSRRVPVDECQRQVPVLRPSTVLSACPAAGHPHGLEISLSGVLRPCSYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI69</accession>
    <name>A0A4Q9PI69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_980918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145207">
        <property type="protein sequence ID" value="TBU53691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI69"/>
    <dbReference type="STRING" id="114155.A0A4Q9PI69"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="257"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="59750" checksum="FE969E18C6A3A272" modified="2019-07-31" version="1">MPHKYTSPSDAPHPFNQPSADITLRTSNAVDFHVHTAVLSIVSPVFATMFQLPQPQQPHREEATGTPPTRPIIEVAEDSRSLDPLLRLCYPVKKAELRTPKEIQPVLAAAIKYDMEWPTEILTKAALDCASSYPLGVWATGCRLGLESVARRGAEAYVESVQEDERKKLLYIPRITSILDEMQGISASHYYRLLNFLHSAKGVADTVLFVHAPRANGTPRSQAALDESSKREASECLPFADDAFPSIAYPAEEVPSSDVICRCPDGMELRAHQSILSVFSPVLKRRIAAINAARENNQPSDSPRAIPVLELRGRSIAVCALLAICYHPETELLPYGINRCIDLLAAATVYKVRHVIDLAFARWKSLVDCDPLSSYFLAHRRGLAAAAAVAASGTLAISGVSMQQISVLRIMDELPAWTYHVLLEYHDACSHAVSEQLDDAKTEFAIASGFGGKTSSPREANCLYKSVSRRLNEQQEALKERTVAPKADHVAGLRNLADVATDIQYHKLWPVTYNLLTRLTETLPQRIEDAIGKVKFDIEVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIG4</accession>
    <name>A0A4Q9PIG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_162210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIG4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="344" mass="38269" checksum="E7A60449BF43D5FB" modified="2019-07-31" version="1">MSSSVNLSNLRLTVNSMHDRAEEPSAAASTSKTPNRRSTRKRKSRRVPDESETEGASSRPARKKAKTRGRPRRERCSPEPDEEGGENEGKKWEPGRDRGEKKKKHLIDAAYDILNVDRSLIHDDFPSSPPSPDYFYNVDKHPDEDARAELAERVRDIPGCEHYTSRQVYAYFGNMRFKTREGHVPKAMRRLQEDGRLPGEHFGDTRAIPSIGESSRASRPDRAALSKEAPNALPNVSVVSQLDTLLKSHPSLTYEDAARWAATLGGGIISINPDDILTYALLKQASTTQRPLDAERHSEDPGEDDGSRERAITPVDLENTFMRPLFIGSPSQSASEAEVSLVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ15</accession>
    <name>A0A4Q9PJ15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_828755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145198">
        <property type="protein sequence ID" value="TBU54056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ15"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="16664" checksum="4EDAD897FDFB51AE" modified="2019-07-31" version="1">MSPSLPSHLFGHACVLGGRSGRRQAGECQCRALRALEATTTGHRKSTPAALETLPITASSSTSPSPHGDCFPNSGSCTLDRSVGNEGAASFWPVQRAPERPWLLDSPFDLATCAQARRSPDPMSRSRMPIDDDEDEGGDWDFRAGNFDGDDAMGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL32</accession>
    <name>A0A4Q9PL32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1031544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL32"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL32"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="289" mass="31334" checksum="70A9490BE55FA574" modified="2019-07-31" version="1">MPPARPAHARVYSRTRKQVRIPRILSLVADSHMQENEVQSEAQFQRILASFSDPPKRPRTPRPASDRGRYPEEAGEDEAQRESTPSDDEDLDDSVPFAYTESSAPTKPVTPAQSINGDDPLMLESPIGGVAMDVDMPSSAVSSPIVSSWRYTPPPTSTSAVRNNKRKLDERYDPYPTAAKRRAVSPSISHLREAFNGRLSGAAPRLTMPIPIPIPNGVHSGASSPSVPGSSSYWSARQSFGSASVLSSPTLRAQIGLASPILRPMTRARREGERDVDNAEEGVNGLSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLT7</accession>
    <name>A0A4Q9PLT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_826556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLT7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLT7"/>
    <dbReference type="ESTHER" id="dicsq-r7slz3">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="45"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="287" mass="31368" checksum="85219664D057EC98" modified="2019-07-31" version="1">MSATSPSESAYSVEDRLVPVEGGQIKVRIVIPTTDDEAKTFPVHVWIHGGGFVFGDLDNDDYQLRKISVDQQIVTVNVDYRLAPEHPFPVGLTDSLTALKWVLENAASIRVDTSKGLIVGGDSAGGNLATSIGHLVRDDPFFEGRPVTGLLLREPSVINPAAYPDELKADLLAYDEYQNTPTLTRAGLLQTRAWLNAPPADPRYSPVLAPSHAGLAPAFIQYNEQDPLRDDARVLEKLIREAGGKVKSVFYPGVPHAFYYLAPSISLAQKVWRDTEEGLRWLLAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMB9</accession>
    <name>A0A4Q9PMB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1029437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMB9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7484" checksum="FF4CEF053D0B1F39" modified="2019-07-31" version="1">MPSLCLICRGAPSRAEQHNYLRENIDPRRERYITATSHPVNSTRQSRYLVTYAMRSSSSVRVVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMH7</accession>
    <name>A0A4Q9PMH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_684390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMH7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11825" checksum="C5D17F990ABB1D2F" modified="2019-07-31" version="1">MARNIPSHRLLLRKVPSVLHLFDHGPLWPLLTGRTQRWNTNTNLSAPAPLSPTLRSVTRAPCTITTPTFITFAVLRNVCVMFTRILGKEWHRNRSKTQCDVPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNG3</accession>
    <name>A0A4Q9PNG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_654165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNG3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9947" checksum="8473CF98150882C4" modified="2019-07-31" version="1">MHDPTNLHDYRRRGEGATRRTVVLGAQLSEHWGRDSTRRNCRFRLSGRYFILCATMRFYILCFPPIRAVRNRSILPASILYSMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP95</accession>
    <name>A0A4Q9PP95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_968866</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP95"/>
    <dbReference type="STRING" id="114155.A0A4Q9PP95"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="212"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="387"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="871" mass="97856" checksum="A77CA49F78B360E5" modified="2019-07-31" version="1">MHLLDTYTGQFVEKDPKDEDTVYAILSHTWNHDPPEQTYDQLKKIQERYAPVSAGPQIGTEVLQPPLSSSPRGLPDGVTCLPPVQDSSPIPTPSARTLHVLLPSVAADGASNPTNSTTADSYGQANPPAVSTGTCRPGHTLRRIWRFVLLNFACRSDIDVDPTPAHPPEVASTSESPSTTSESSTPSPDPYPPLPSHDPSLPSLSRIWEDPELSPKIRDACAVARKAGYQYIWIDSCCIDKSSSSELSEAINSMYHWYGYAAMCYAFLADVPPDDDPREIGSRFRQSRWYTRGWTLQELIAPLQVMFLSNEWTVIGSKTVLADLVEEITGISGEALLHVKSLDEFSLAQRLSWAAKRETTRVEDRAYSLLGLVNINMPTLYGEGALAFRRLQEQIVQRVPDQSLFAWEHVYTSLNPGDDLLTVLRDDLRITGWPHNTWTKDEDEHFPTLFADDVESFTHAGKIRALSHRAVLRRLEPFRIPRADYTFTPHGIRTQLPLIPISLCLPSIKDDYRRRLNCHYLAILRCEHVDYPDHLLGRFCYVPASNADMDVVYSGRTRFALANYPQPDKVLGFYGLFPVSPATIKRCHKAILLETVYLSHPERSFPYPQGSLRLPHTMISLILLKATRDALLAKGYTAELRGPNLNHPTAHWLTLSNDRHAITIKFQHTLQHGGGSLGIRVDAKVPEQLLDPLGGAEDIQAVVNAYPQASPVYFMDQTPWKTSLAPFSQEQILYWSSPPPTPIESSEGRKSPFPWSYIRDMQVRYSNRRPVRLSFLAPEYPILELGMNYGGGGYYILQVDVFGETTEREESEFSMDDVDWETRASHIESESEDEGGREVLQRAVDNGSTSESVLTRWMEEVKGVFRLDGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ06</accession>
    <name>A0A4Q9PQ06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Bestrophin, RFP-TM, chloride channel-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_882565</name>
        <name evidence="10" type="ORF">BD311DRAFT_730156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143487">
        <property type="protein sequence ID" value="TBU24104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ06"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU24104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU56430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="520" mass="59111" checksum="F00FEA9D76F9CE27" modified="2019-07-31" version="1">MVAHNPLFASWSLRKFKATVINDIWPEVLFFSGVAAMVSLVSDLTSHKLSFSSAMLTVLGTVLGLVISFRTSSAYERYMEGRKLWTAIALASRNIAQVIWIHVPFERIDKKTGQRRSNLEVVIEKKSMINLVQAYAVSVKHLLRGEAGVYYEDLYPLVCFLPRYASHAPENASEEDMLPMWRASAMDAQKHRAAHTLTSSRPLSRSGTANEGSPEPEKELGQISEDQIYHSLRGRSREALKKARKFDPEMALPVVYSEHPLQPARNPPKESIFDYLPFLRVFKILVAPFRRSKPKPELPTSASAATRSFTGKRLRPEAVDSNVPLEITLFLSNYLAWLLKNGQLQPALASAFVTAISSLQDTVTNLDRIRNTPLPFAYQAHLRISLWIYLFFLPFQVWSSFGYLTIPGTAFASFLLLGFLEIGQEIENPFNYDLNDLDLDSFCLQIQRELHEITAHSCPDPDEFLFTAWNQPFAPGDRRTAEEMMNDVNHSYHGPDTGMHSIRRTLLKSWWDVDEITRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQF7</accession>
    <name>A0A4Q9PQF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_960140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQF7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQF7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="141"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="513" mass="56846" checksum="FE18FB6D2D5CF5A6" modified="2019-07-31" version="1">MADSLASVIDQLTSISHFLSQPLVSTLFHYHPNNLGQSSFDPPPEWEGWWDWAGGECEAEVGTELDDPWLLLLKYYNSRVSGHECSDKTSSVPPILRSLINDACRLALPRDIGHVYPDGRCSITQLPNDLKSQALPGMSPKKAHEVVQMVGFLETLLSFQSSLGSLNHVVDIGAGQAYVSRMLRDRLNLHVLALDWSEVQKRGASRKDASKIARRARPTQREVVNADTASPASDTRRTALGPKAGSMTYVTTRIDADSLVSATDAWVEDRQAVISNNDATPEVTPVLFIGLHACGSLTTDIIRAFLSARRAGTSLRSTSWMPHGAVIVGCCYNLMRSEDFPLSRTLAAQVPSQWLRSQQSLGSARLAMRKIAWRALLEDHLQETQDDVGHERLGSEANDGGTAEMHRNCRKRLGRLNDQVFANWETFADVVRTKLHLQLADWSRPPSRVEKRIEVMHMLRCIVGPVVEAYILLDRFAWISEELKGTPMAVELVNLFDQASGSGRNVAIVIHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQN3</accession>
    <name>A0A4Q9PQN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_605649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQN3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18246" checksum="B45D11F2E3B50B33" modified="2019-07-31" version="1">MATETAQYARIQNRDSVVSDAPTSSSRSLRRRVSHALSSFTGRSPENSTVVPPVPPTNELARPATRIEKATSRMASGADQRPENALKRTWSRGINLARTRSEPALHAKRAKTSASATAPAVPALPRAATTTVAGHSRDVSAYASTESAIVSYTYPLWRIDPVLVGCFVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQQ5</accession>
    <name>A0A4Q9PQQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_968559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQQ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQQ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="539"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="652" mass="72822" checksum="3874D3E05CC2D292" modified="2019-07-31" version="1">MISSDVEKSRHQRPLDAIDWQVYRNLSLQPHGFGKERVRIWPRLLNVNDRAYVSRDKCDAPDSSLWSDASFDLTSPQEQQELPGNPHSDERQITLDTDRSFVLYSVEGVDSREKLQAALNRLIVSVFRQRPRLHYFQGYHDIVSVVFLTLPKELHLPVTEKLSLHRVRDSMGPNLDPVVGLLRVLKRLLELVDPHFAESLERTAPLPYYALSNLLTLFSHDVPTLPLIQHIFDYLLCRPPIAVVYLAAALTLTRREEVQMLEEEGEEGMMHSLLTVFPDLYEEGDDPPEPHKAEVMPTSQDMEETSTKEEDPDAVDSVSENATPALALPSYQDTSIPEEDDYDEVTHSASPRIQAELSAGDTSDEVSTDAGSETLVDSQAPTPMADGSTIPVTTQASSLEPDVRVKVQRSEPPLRSISDDDTEPSALISAEHEKSPLSPAEADQLLVPISDDEEKPPLPPTPARTSSPEPLGRPRRPRISLTTLLTRADELMREYPPTHPQIALSTIMGPQSVVHTWSERARDLPSDDDAERMVLRPDLIVCPPPPEPVPSDDEREREHERKRRERRRKLRKPRRLTDVIVQRKTMVAGAVLVLGVAMAVYGFNGGALTGMGGGHGGHRGACGREWRRVGKLLGGFMVGAGERMFEGIRQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR26</accession>
    <name>A0A4Q9PR26_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">BD310DRAFT_930604</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR26"/>
    <dbReference type="STRING" id="114155.A0A4Q9PR26"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="237" mass="25738" checksum="CBD64C7320D511C9" modified="2019-07-31" version="1">MDTLGFLTLISVLIAALTLLRLYAVLPSTQTAKPSGLREDSDVCSLAVFLGSGGHTSEALRLLSALNFNRYGPRTYIISEGDTLSMHKAMDLECAKSTEASQTTPFTSGPDAPCSFVVIPRARRVHQSFLTAPFSAALSLAASIWHLTASPLFFGPPAPDVLLLNGPGTCFVLCIAAYLSRFLGLKSPKLIYVESFARVRHLSLSGKLLRPLVDRFIVQWPDLLQDGKRGECRGWLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRF6</accession>
    <name>A0A4Q9PRF6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_588734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRF6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25626" checksum="BAEC3056BF2A40D1" modified="2019-07-31" version="1">MSPEDNMSNSPDFSPSDSPTMQSLVLPVEVIEGIIDCCSYYTDTLLAFALTCRDLHPRSILVLFTEVRLRSRDRVLDFCDVLKAKPERQSIVQSLSLRWEAFAPHPLLSILSALRQITFGGRVCDPVQCHPSTLLCCRQSGSGLRSLTIQGATFPTCTAFLHFLSAFHSIEHLTCEGLQLKQKGEANPFVQHQLSRQLRLRTLNVGAIMGASVFLVNCDLDPFSYRCFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRX2</accession>
    <name>A0A4Q9PRX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_570870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRX2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="20138" checksum="0D2F5A05F00C1430" modified="2019-07-31" version="1">MARVQPVKDPLWEASLFRRVLASFNPPAVFALLILHTSILLLRIATQFSTSITLLIVILFFDSSTTLLVAPTLVVARYMLIVLSISNVFIIVARWLILALVVKCQGLATDEEVDAAMERVRDWVFTFENFASMLAISKWSTIVNIVTPVPENGAHEEMSLVFAIGVWVVGAVAFCIQSMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSF3</accession>
    <name>A0A4Q9PSF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_929533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSF3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6568" checksum="4BCB94E621ADF90B" modified="2019-07-31" version="1">MTVCSRMNALAAAPATEWWLPPIATSRKRCSNVHREVPVIHAPRHIVPRSQSAGPRGRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSN4</accession>
    <name>A0A4Q9PSN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Histone deacetylase interacting domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_880877</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PSN4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070822">
        <property type="term" value="C:Sin3-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="9">
        <location>
            <begin position="514"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="305"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="827"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1297"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1410"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="828"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1339"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1363"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1423"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1433"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1497"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1507"/>
            <end position="1528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1536"/>
            <end position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU57446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1578" mass="172343" checksum="64CCA4DAD07C60CD" modified="2019-07-31" version="1">MDTHEILAPAEGGLTVGRATPALRSRPPSPHRLPSQSMDADPPNQPLESPTSLGPVDGQIHAAVAGSPEQQGGGERPLNVSDALSYLDSVKLQFAEQPEVYNKFLDIMKDFKSQLIDTPGVIERVSNLFHGHPALIQGFNTFLPAGYRIETGDNADPNTITVTTPAGTTTQATNAAFKYGKQQTVTERVAETVNPEPEAPVVSQESLKPALEFVQKLRTRYANQPAVYQRFLKTLAESGNQGQSDISRMESWSVACLSARYPKGEVMTEIMDLLKDSPDLMRDFVQFLPDERVQKEELARIARLEESRKASESKPKRATKEEKENPSGSVATGQKRKRKPAGDKEKEPVTKTSANKKAKVQTSSEAPSPALAQRQAAAAAPPSPIRAPPQPPPRAFYLHPQQTISLAPPMPVPVQATSSIHPSDEKHFFERVKRVLDNRETYNEFLKLVNLFTQDIINTTRLVREARSFIGDGELMAQFKDILGWDANKERMAALEESWTRPMGVLDRPSRHQLHNRYGSYRKLPAHEVNVQCSGRDEMCNSVLNDEWISQPTFQSEDAGFVAPKKNVYEEALHRSEEERHEYDFHVEAIHRTIQVLEPLNNKILQLTPEERATFKLKPNLGGVGKAIHQRVIKKIYGRDLGIEVWGAMQEVPATAIPVVLGRLKQKHEEWKRAQREWDKVWREVDARNYHKSLDHQSVTFKAADKKAITQKVFVTQIEAARDEQRVNRAALIDPLFARTKPRHQLEFVVEDPAVLQDALKLAFSFLDRTQAQISLPDRRKIETFLRSFVPLFFMLDATAFNAAFVPHHESLDSDFELEAVGEDVEMGSANGSTSSSRSRSNKKGNGANAAGDLRKRLLKSEQAKSSRRTRAQEAASPTPSRFASPVPSDAMPVDGDAAKVENGISRLDKSTSRRRGTFYTNTAFYVLLRLLELLYTRLHLFKNLTKEMADRSNDPFEPNPSSIRSTIQADLAKLGNRLDQSSHYYELMLESCEKLFDNEIEQPAFEEMMRYMFGLKHAYKLFTVDKVIGALIKQVQTILSDPKSQDLYELLRREREITSPTTQDLINCRRNTERVLGPDENLFRIDWLPEPKTMTIQLIGKDDVTYDDSEAMTGRWQAYIESFVSHHYTAGVPSSSTIRRPFLLRTKVPSPSGAMPEIVARGGLQIKVCVRTYRLFFVSRSEDVMVRLSSPQERANARKAVELRNGKRKKWLEDYASKHVKDEPQSATMEVAPQTPAVGPTHPLTASDSSPKPLAQPAHPPVTKEVDMEVVGRARERQPEVSVFTSPQDDPIEAAAAAAAIGSAPEPDPDDVAMGDATSALERLVQEAAPVASAMEMDSAPDTTAPSAAAKLGEFGSSPGQASSVPNAQPSPAAPASASSSAPAAAASGAASNIPVSIMATQSIPADRPVSTALPAAHAPPASTTQSSKVLSESSPSTPTPDPSTTSPEQQPLLAVSARPSSSAWSGSAPRNTSSGSSSGSIASSSEPAAVSASAAPPPPTPASPPASTSASALVEASSAPAGTTAAPGPPSPAQAPAADTAPPHLEAAPNQTTLEPPPQGATEERHPPSGAPSVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSW8</accession>
    <name>A0A4Q9PSW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_548928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="400" mass="44354" checksum="8B65681DE6416385" modified="2019-07-31" version="1">MDTTNIYNAWESLKRSARKFWVLPGPVPVALYSFNPRRVSPILKDDVKNFVADVLQVDQDSDGVEVRIDRHTYEMTKKLHLRIREEVRVGTKGKSSAEARIAKEIKETSKALKKVARRRDRVSAIAQGHRQELALLQSQPPCEPPAACQPLASSPQPSSRQAMREAQFAEKHMGVPRTIYLATKAINGQHPSLTKSVEGHGRETHRSPLVRRARAHGLPFCGTDRRPANKYHPPFNQSGAVVPEDVFANFDEGRVGTIVDFPRRDGYGPVPMEVTAVPPGSPMKGLRSAPLEYPTVEMEETSSEPTVCSAPPSHSTPALPQSQRPPTMSTYCRNLGHVSNEMAYALRNIRAANAREQSRLPQTTPVRVRTRAGPTRARVVPPTPVKSRRQGRLVSVGGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT39</accession>
    <name>A0A4Q9PT39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_968142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT39"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14787" checksum="5CD6342213EFD2C4" modified="2019-07-31" version="1">MQQAVARVGSRAFEGLIPSLCTLHMRAQTFSPPDVLICRSEHRVSGAVYVPILHEAAVSSTTAEYMRRDLCYFHRLFSKCVPGQMKGVCKGSRTSRPEACHDSAEGGPDMYMSRNDDHVATSASTKVWTRRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT56</accession>
    <name>A0A4Q9PT56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_968089</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF881">
        <property type="entry name" value="FI07970P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="192"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="370" mass="42865" checksum="A8B466E37958D963" modified="2019-07-31" version="1">MPGATLPAVTHYQRPPTTKEDLVWADLPIIDFSKVGTPEGRAELVPQVRDAMRTHGFLIVINHGWTQAQNNRIFDVADVPFTQVSEDEKKRFQTKTQETGTPEGYKLRRSWTVNNGVRDELEYYTFFGQSDHPEALQPFLPEYHEFARHNHYNVLYPVLRLLATGMELPEETFVDIHDFDETAVKYARFLKYHPRAEEEEVKADNVWLKGHTDIGTITVLWSQPISALQIMSPDGKWRWVRHIENALTWLRQDFWFQVVNIGDAMEMLTGGFYKATIHRVVQPPKDQRGFTRLGAFYFAMCNDDVKLVPFTDSPALQREGVVRKVEDRDAPTMRDWRKARSAAYGVSETKRKDDVVEEQIINGVVVKHYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTL2</accession>
    <name>A0A4Q9PTL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1039566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTL2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="55002" checksum="44D64B9DEB22C6B3" modified="2019-07-31" version="1">MPFLRHLSLAIHPPSAELSSALKDLLLELAPLGRIQSLRIAPSEAYISSDPELAGALTALSSLTHLEFRGAKAISCGVLDGIRSPLESVNIRLIENWERLSPDEADYDDNISRNAYDNAVDVVGHLHRFQDTLRQVELVYPLKSAPDWPALPRVELLMINYFYAPITLHYVRAFPNLVHLVVGDVIDFWGNMLHTTVHEHRECNRAQQAEYHRAWPSLRTCGGTLHALYMFALPFHIARLTIQCISRCLCGVEPAWLSAVLDDVRPSHLQLHIWPVTHLHSVWADAFRTALTVERDHPLESLHFMLRLSAADIDLKVDDLVNKLLELVRGLSSLTLFSMEIICDGILEIPYFVMAAQPEDHWSRPLLGSFDPGFLFCVEDELRETDMGVVAKRFLDAVPSLKEVAIRWKGRRQLPIDVVDIRLRRRKDPVGQGEIVESEMKVLIHKEDGQGIDEEETDWESEEHEADDDDDEDYVPDDEDYDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVM2</accession>
    <name>A0A4Q9PVM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_926827</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVM2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVM2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="135"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="4">
        <location>
            <begin position="309"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU58540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="698" mass="78960" checksum="2DE8CD402932EF7B" modified="2019-07-31" version="1">MRLLDIDTGLFVWVGDPRTASYAILSHVWDREGEQTYQDLLRLQQSFLPVIGTRPILLWIWAALWWRILLAISFLLSVGRDVVHRRQLIDSLPFRHIAREETLEYLARWLAGWVAVTHGAAVDIRSRRTYLHGNIISEKVRRACQVAREQGYRYIWIDSCCIDKMNIPECSRAISSMYSWYREAAVCYAFLADVGVKDSFVFEFADFRKSKWFTRGWTLQELIAPQVVLFLSADWRALGSKSTLAAVIEDVTGVERTILRKQKALATVSVARRMSWAAKRQTTVLEDRAYSLLGIFDINIPTLYGEGGRAFIRLQQEILKQHPDQSLLVWGKINLEPLLPLVEDSPSSQGRVQRCWREPEPYVASSLLAHSPDVFGWSKGFIQDIPYDVFLHRIGLPDFTLPVYYESPYGIRVDVPLFKLSDVLPSESLDQQSQIGDWYIILLACEHRGHLLGRVCYARPSQIDVAVLASGQLAITTSSQPELSSPKYGIIALSPEFLERCRSKLQVKTVYMPLPHVYTNLAFVVPPPAPPPGQQILALASWVYPALASQGYSILAGTTVEEHHAGTLLLVRGPADSIGIAYKYTPERQTVQVSATMLGTYIDVARGVSRPGPSDWLTWMLYARRIEFQELRFRTREGKDVVVRMNLERMYDHTPPLRLGIDVIEQDTGVRYMRAEVSPNATDSEASQGGTTPVGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVM3</accession>
    <name>A0A4Q9PVM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methionine aminopeptidase</fullName>
            <ecNumber evidence="6">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_819110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="6"/>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVM3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVM3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF8">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="8">
        <location>
            <begin position="125"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="361" mass="39650" checksum="10F7A525DDA3E71A" modified="2019-07-31" version="1">MRSLSSLSRAASTLSRPPRPLVGHARQRRTQPLALSHFKRQITSESEQPQSAEPSEHDLRYGFYGVILPEEPFVWGTSHMTPRGVPPQITRPSYVPDPSNPDAVLEGGPSRAKRKLITDAEDLQKLRRAAKLAAETLQFAELLAQPGNPTDFIDMGVHEFILEHEAYPSPLLYKGFPKSCCTSVNNILVHGIPDDRPLQDGDIVNVDVTVYLDGFHGDTSRTFLIGDVDEKGRELVSITEAALEVGIAACGPGRPFKDIGKAIHQLLRGKDYSVSSAFTGHGIGQEFHRQPWIHHVLNDEPEIMQPGDCFTIEPAIVQGDDPSGVTYPDGWTVSTENCARAAQAEHMVLITETGAEVLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWL5</accession>
    <name>A0A4Q9PWL5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_818459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWL5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="822" mass="92163" checksum="CB83F49A84C2DC81" modified="2019-07-31" version="1">MAISAVQISSTQFRDAFLPGSANVDASRPDVSNPFAALQLANQIKERQLSKRFMAIVNDHNLVQGLTCSSYQQQPTSIEYDKIGHHTTAALFRNTSIPKAGQPVWADQLLPIQFKAKDPGVDPFSDIERNDEYGFLDFSRKQLLDEISATAELLLAAQQRVFLFMFLVIGRRFRLLRWDRAGVIVTPPIDYVKQPSVLCDLLWRISHLNDAGIGLDPSATRVLPGDVDFLRMDLAAQKNPKDMSHMEREVSASEEEEPFVFDYVRSLFRLSISNDWPRYKLEVADGTASRGYLVGKPTFRAPGVTGRGTRGYVAFDCKTGRFVWLKDAWRASYMISRREGDVLEKLNSAGIEHVPTLVCHGDVEDQVTITADWWERRCPISTVSSSSSAGSSESSSSTLSVSASPRSRKRKRMQATSGERSLQNSAYSSSSTVGSDQPLPEHKHYRLAVEEVCLPLKNFEYGRQLVFVVLHCLLAHHQAATNPATRLLHGDISGGNILIYPRIKRTYDGDSPMMLWTGLLTDWELSKSVGDDEALCTASQGTYQFMSVNRLLQVEPKAIKISDELESFFHVLVYYSVRSLHSNCPDVSFWIDEYFNTYAALGRMYPCGQKSSTVESTGRLQTGAGEGPLLFESPMDSILATMLQCLRAHYKIIQDEGRKLMSAAPARSHMRRTRSSSPIFDLIPLDKYDLKAILEEEEEEEYTIPKTNYLPASSCSDAPTARDRDLASKITTHDYFLNVLNSLVCHPDWRGGDRIPKSSQCCKSSPNVKADASKLASASSRTDRETSNKRRRTSGPERNVSLRARLRTSTRHAQSFPVRETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXX5</accession>
    <name>A0A4Q9PXX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADP+-dependent D-mannitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_925036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXX5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXX5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08234">
        <property type="entry name" value="threonine_DH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050129">
        <property type="entry name" value="Zn_alcohol_dh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43401:SF2">
        <property type="entry name" value="L-THREONINE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="6">
        <location>
            <begin position="29"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="176"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37455" checksum="FAE6ABA18E0AED16" modified="2019-07-31" version="1">MTIPKTMEAIYYEKATSFKLATVPVPQFQPHEVLIKVSCCGLCGTDQHLHSGETSMASYPFIPGHEVVGVIAEVGSAVTGFSKGDRVVADPLVECGHCFFCLRAEFVLCENLGAHGVSITGGFSQYVVFEARKVFKIHNISDEEATLIEPTACAIHGVDRLEVKVGVEALVIGAGPTGLVLAQLLKLNGATKVVVAANKGVKTEIARKLGAADEYVELDRADPKPQWEKLKKDYPYGFDVVVEATGSAAVANDAINYVRRGGKLLVYSVYDPSALVQWSPAKIFIDEIKIIGSFAQPNCFPRAVAYLDSGKVNVKGLVTDVYKLSEYQQALDKYKNRDVGKIAVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYQ3</accession>
    <name>A0A4Q9PYQ3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_947679</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYQ3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYQ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="521" mass="59232" checksum="FCF781348DDCC5E5" modified="2019-07-31" version="1">MGCHEALNNGDVVYLVISCLTPEIEDRAPQWKQERRERNKALARFACVCKSFRLPALQMLWRRLESMLPLLRLFSALRHVKAEDGDNEVDLHVLSGEILPHEWERFLVYAQYVRTVDSASRPVGFAAQTRIAPSVWSHMGRLACGNPLLPNLQELGWVVPSPQCTGILPFLSPTIAQLNIVCFGIDGDAAADIEHEWNVSLQAILPTVFSVACQITRLTMTTGQIDYFTPHLASLRFLRYFRATRVNIRTLRILAALEDLQELHVGNFDTADEAVISFSGFLRLRTLIISEHPSSSSVYNAFSSQELTKLYVLEYPGEYRHALPETCEIWAHRFPSLQILCFYISRHSGDDASQVRPLRDAITPLFALSDLRTVGLATWHTMFSIDDSDMAACSQAWHRLEALRLSFPFGTNDARMDSNTCPTPSSLLAFAKKCPELKELRIRRLKVNRDNLLHLNTLTSHWSHGLRYLDVEHVDADDNVVPDLARWIVRLFPHLVPQVRNPDQSWKRVLDAVRKCQSGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ65</accession>
    <name>A0A4Q9PZ65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_362067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ65"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16378" checksum="1985B1B3AB3EEB1A" modified="2019-07-31" version="1">MYIHICAVLARRMIVGSAVVKPSICDASAGFMCACYAVLHSASVRFSIGRGLSSCFVLRHWPTSRGGSPPHRTIPVRSRTLRRDHHNRVCQSPTPVSLPLMTSLRRTARRRRTTTPNTVTVATTSQGRCLSRHRRNRNRLWLSSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZD8</accession>
    <name>A0A4Q9PZD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZD8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10931" checksum="E418A88A9A42737D" modified="2019-07-31" version="1">MAPERASVSMAACPRWIRATSSAIWSVRASVRAFLVYNDLILSDLAICPKPRSCMRKGITHRPLRGELLGDAKSTCSPKNLMRLLPSICTMQEISPLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q196</accession>
    <name>A0A4Q9Q196_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_874806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q196"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="768" mass="80717" checksum="DB5813DA426AE6F1" modified="2019-07-31" version="1">MHTALWTLVTLATVVSAEHWIFGGVRPIVTTRLDPVISPNAIGSHVHSIVGASRFQNVYDPADLVQSNCTTIPVQPDKSNYWAPQLYHQDQNTSLFTPIPTSFNIYYLMRPGPMNESIKAFPPGLRMVAGDPNRRSYNASDFAQQAISFVCLDFNADHSNDPDWDERPNFFDHNCPDGMRAQVFFPSCWDGVNLDSPDHTSHMAYPIQNYNGGDCPDSHPVHLVSLFYEMFVSVDQFDFWGNGTWVLANGDTTGYGHHGDFTNGWDVDLLQNAIDNCPNATGNVMDCPPLAAAMDQASADACVLETEIVDEDTGFETPLSALPGCNPLWNGTGLRTECLSDAELPQLIPAQTPLPTNWSEIGCIAEGTNGRALIGASTTSPNLTRAACVAFCESKGFALAGVEFSDECYCDDKLRNGATNTTLIWNECTNHCAGNDNEICGGPARLTLLVTSNPPPPPNDTILPDGWSFAGCVSDDPARALTGFSTADDQMTHASCVATCSSHNFTIAGIEFGRECYCGNAFENGAGQALDPASCNVVCAGDALSTCGGSWALSAFQSNATVALQSSASSAAPSTSASLAVSVSTTASQVPSVPISSASPASPVSFSATSTPVSSASSVAGSATPSISASTSQSIATSVPASSSAPSNTTVVLPDGWASIGCRQDDVSGRTLDMDAFTSDNMTIPGCIAHCASLGHPVAGVEYARECYCGSAFVNDGGAVLPDDACDMACSGDTTSICGGPGALSAFQDVNTTAVARRMYRPRGSYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1W2</accession>
    <name>A0A4Q9Q1W2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_921684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1W2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="432" mass="46458" checksum="E92E97304B33EC61" modified="2019-07-31" version="1">MSMSTTSTTTFELLKYSRAYGHSAQATQPAELEWQHFVNPVIRLMLDTRKTTDGRLESYKIRIVWTFSAGRDSMDVDRREVDFEDLDLLSYSSLPARQVAQGMPLKAVYQGAVVGLRYQYPCVPCSGTIPQYRRFQITFQNESSATNFIDCIRFVCPCKANPAPPARAPRPSETQLSLAASGRSATTTHIPMSMSRSSASDSRQALSVMPEEGAASKTLQPAAFALLPSPSLSRRMDWDTLTQPSQPTAPAPSVATPVSRPWSASTASSVVAHQSASDTIPSDVLTTGRAASLHGSSNDVETSFPSSSLPSSSPPPSSRLPARTSSPVLMPPPPVPAQMNPPRSSQPSQTTPTSTPRTASSATLAASEPSSSGPELKSDISATLRDSHGLYALSAGELEKLVAEVIREEGFAELMRNLDGMWKIKGLVDIHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q228</accession>
    <name>A0A4Q9Q228_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_874625</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q228"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q228"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097039">
        <property type="term" value="P:protein linear polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF13">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="276"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="442"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="736"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="740"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU61001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="103881" checksum="B36CAC30B979D301" modified="2019-07-31" version="1">MTQSTAATPARPCLYYRQGSCTRGVHCKFSHGIASPNGPPQSSQTVRDRGKPPVTTVCGFYRQGTCRFGDSCLFSHPSSSSGHLSNGTDTLAAPATRPTANTIVSYRALSESTTFGSCKFYARGACNKGTACPFSHPATAIVPKGESDLSSMQASAFGSVACKFFVKGNCSKGSTCSFWHSQQQAGNDVNIPPISEVADVVSGVAPVTGADIASARGGDGSFSPKQTSAVERGEAAKSDSTSHDEQPSVDRTKFGCKIVYGPGGCVQDIETAFESTIVLLHNIPSSVTHTQLVDLAEPFGPVKSVIIVPARDGVSPTSGRIEYVQTAGAARAAAELGNAKGLRGATARLDLRAAESGKAVLRSTKAKLSWFAPSLVAWAHYATLSKAREQAKRLDGQTFRGATLHASFQTPSRYQRSSFSVELKGLPLDTSSASLKIFTRSDSVALGSPSFMIEDSVRELRKLLATYGSLEAFDFAPPAQGKYKLVAFVQFADADKSERAAAMLHTKRQSFLRGSPIFLELVHSIKYMLPSAQFQVLRPQIDALREILQTCKLRYHDKDEYGREAERVCIRAYGPDAKGLGRLKTEIELLLAGDPVLDADGQVAWHDHYSTASGTQVLSSIATQTDTYIKCDARIRTLHLFGDQHGRTAAKTRLFVVLAKLQAQEHLLDLDQEAFRRMLHGGYQELQTAYEDKVRFDVVRRRLVLRGDESEVRAIRESVAGQLGGGQRVRSSIEPDDGQCPVCFCDTAEPLTLPCGHCYCRACLQHYLSSVGQSQGGSQVFAACLAETTQPNGSRRACGRGVPLGIIRSLLSPGEEEQLLEATLLSHVHSRPQEFYYCPTADCQTIYRSSADDTVLRCPSCLARICASCHVEFHEGLTCVEFKDNVSGGNEVFRRWREENGIKSCPSCKADLEKSGGCNHMTCARCGTHMCWVCLKTFNDIDSGGGVYAHMRREHGGIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2V9</accession>
    <name>A0A4Q9Q2V9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pre-rRNA-processing protein TSR2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_920971</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TSR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2V9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2V9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019398">
        <property type="entry name" value="Pre-rRNA_process_TSR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21250">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10273">
        <property type="entry name" value="WGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23468" checksum="687F3775EFB2E3D1" modified="2019-07-31" version="1" fragment="single">MVPAGSGCRRECSASVPSHHHSHLRIYMASSSPPQSSVFFARGVIARLAYWPALRIAVDQGWGGPESAEKRTWLASVLVDDFEEQIPKPDLDYVEDRLLQVMADEFDTNLEDGSAEAVAKDVIRLWEEVSVGKTELLKEFEERADKLKGKKVDVEEAAGDNSDWEDMSDEEDEEDEVPQLSERPRPPKEEPEVDEDGFTTVKGKGKNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3M7</accession>
    <name>A0A4Q9Q3M7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Glutamate--cysteine ligase</fullName>
            <ecNumber evidence="3 11">6.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Gamma-ECS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9 11">Gamma-glutamylcysteine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_946439</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteine + L-glutamate + ATP = gamma-L-glutamyl-L-cysteine + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13285"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the glutamate--cysteine ligase type 3 family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.2" evidence="3 11"/>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3M7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3M7"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004357">
        <property type="term" value="F:glutamate-cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000009">
        <property type="entry name" value="Glutamate--cysteine ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.50:FF:000002">
        <property type="entry name" value="Glutamate--cysteine ligase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004308">
        <property type="entry name" value="GCS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11164:SF0">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03074">
        <property type="entry name" value="GCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5 11 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="509"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU61631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="661" mass="75976" checksum="BEF18460F82A8B4D" modified="2019-07-31" version="1">MGLLFLGTPLQWDEAKQYADHVRTHGITQFLNIWDRLKDRYGDELLWGDEIEYMVAAFDDQEKNVKLSLRQTEILAKLQSIVNDIASDRSETRSVPTFHPEYGRFMLESTPGSPYTGEIRDLLAVESNMRYRRHLARKHLKTTEVPFTMTSFPRLGIPGVFTEPYFDPADAVSSHSLFLPEEITNPHARFPTLTANIRRRRGSKVAINLPLFIDDRTPRPFVDRTIPWQRNIYPEDPEAKNGAALLDHIYMDAMGFGMGCSCLQLTFQACNITEARRLYDALVPVAPLLLALSAASPLWRGYIADVDCRWDVVSGSVDDRTEEERGLKPLKESRFKIPKSRYASVSLYISEYWMNQPAYNDIDAPHDPAIFERLRNHGVDELLSRHIAHLFIRDPLVIFSETIHQDDTTSNDHFENIQSTNWQTLRFKPPPPNSPIGWRVEFRPMEVQITDFENAAFAVFIVLLSRAMLHFNLNLYIPISKVDENMARAQRRDAVRSEKFFFRKDVFPSASSRPSSVASSIPSSPISEHGGPIHVNGINGKEKKLRNCFPLPPRPDDAYFAGSVHEEYEEMTMVEIMNGKGTTFPGLLNLVYMYLDTLDVDDESRRRIEEYLDLIRRRTNGSLRTAASWIREFVRTHPAYKFDSVVSQEINYDLMVAIDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3T1</accession>
    <name>A0A4Q9Q3T1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_812055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3T1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15395" checksum="B762A9015A4E0F31" modified="2019-07-31" version="1">MSLRACAEYNQQAGFRGCAHLHPLVSGNITSYQILGRSVVVLNSVQAAFDLLDKRSANFSDRPRTPVTELIGWNGNFSLQQYGQSWRSHRRLFWQHLNPGRLNQYDDTQHRESIQFTRKILDKPSGLEEHTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3Y0</accession>
    <name>A0A4Q9Q3Y0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_956481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3Y0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3Y0"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="40"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="509" mass="55156" checksum="F0200D19FC08102E" modified="2019-07-31" version="1">MIEQPYSISRSYIRTVESSQQSTTLAHFHYEVSPATSAMSAFKRRTTSKQPPPPIGTRPSPGSPATTITSTGIPSLDDILGGGLPLSCSLLVLAPDAHSAYGELVLKYFASQGLACGQRICVVDARPDAFLSECMWMPGSSGAASAQSNSPTPAPPTAAEDEEDEKASEHDTKIKIAWRYEQMKQFQTTVQSPDQSADDYCRRFDLTSRVPESTINSALSEGRYLDVRPDESSFSEDESSCRRVLRRVAEILAKAESDSPSASALATHAIVTRICIPALGSYEWGDLSPQDVCYFLHSLRALLRRHPRACAAMSVSPHLCQETYGGPGWVQKLGWLTDASITLAAFTANPSLSAMFSSHHGLVHIHSLPAPHTLLPPSDKFSTLRGLTSSGENNLAFKCMRKRLIFETLHLDVEGGVSERRTTPSSSAFAMEAGTGHDHDHLHQPSTIPLPGGASVAAVQVQLEQVHMAPSVPESQPDLPPAKPESAFKKAKVKKKVAFTSERPDLYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4C2</accession>
    <name>A0A4Q9Q4C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_812215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU61930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4C2"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="286" mass="32333" checksum="B4FE8AA7803750E0" modified="2019-07-31" version="1" fragment="single">KIATGFFSQDDPAADGAAIGALPPRFGLLDDSPQRWKTFQARIDTLNADAPSGTRYKVFYFSRHGQGGADNVAEAKYGTKVRENSPTANRYWSKLNGDGEMTWGPDPELTDVGIQQAKAARQAWKKERAHGIPLPERHYGSPFQRALRTFHDTFVDADFLEGRPLHITILENLREEYGEHTCDLRSTRSAIAQRFPPPVYEFEEGFKEEDTIWQADKRETKEHVAQRAHIVLDRIFSTDNETYICISAHSGIINGFLSTMGRPRYPLPTGGEWIHGCRLVFLNISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q501</accession>
    <name>A0A4Q9Q501_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GST C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_51933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q501"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24540" checksum="339E8B91765EC0DD" modified="2019-07-31" version="1">MWMCRGMAPHLDVGPVDGIRGIESFPAGKLLPGLAVMTESLVILELLADLHPDARLLPENPVKRSQTRIFMNTLNLRMADDGGKWLTNNDEGEAYLDLLETLQATMPEVGYVVGEWSIADAALLPFLMWMEVIVKTRVDYYVRLNNVEHVKTEWASTRFARLRQYYDQSIARPSTSATWDEVRAPAFRCTRAERPGAPSLQDNVINYWLARFAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q519</accession>
    <name>A0A4Q9Q519_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_53028</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q519"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="160" mass="18113" checksum="95857303686A6862" modified="2019-07-31" version="1">MSIYFFLPSSTRNVYAIYSISSKPNSLYHSLDGYPRAEIMFALLHGPKACRNVSKYVACSHQPWFKARNSEESLRCRSHGTCSFYVHRAAKAWRFVVRTVHSTHSCCKERSRSSAHAAHYIVMTGFVITMAICRQGACTGTCTHRGSGGGDWIYWELQMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q665</accession>
    <name>A0A4Q9Q665_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_659807</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q665"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8063" checksum="F11AF463ADE134B1" modified="2019-07-31" version="1">MAGGGTTAAASNRRKNLAGPSSWAGLLANARVFALAIFASLGGLAQPVCHPRSPGKRSTDVEFSLVMPECCRVYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6F0</accession>
    <name>A0A4Q9Q6F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6F0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6166" checksum="0BA696BE37B63791" modified="2019-07-31" version="1">MITVTAGIRPARVQSEGEGLVRGYQAHSRRGWRDNTSIVPCRIGGKGADVSLAPSLGCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6K6</accession>
    <name>A0A4Q9Q6K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Poly(A)+ RNA export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_1036155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat rae1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6K6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6K6"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000190">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="69"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="110"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="259"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="38690" checksum="92B2A94BCF1F8BF6" modified="2019-07-31" version="1">MSFFGTSTSGTLATQPPPDKDIEVADPPTDSISSVAFSPTADYLAVGSWDNNVRIYEVGASGQTQGKAMYPHQGPVLSVCWTKDGTKILSGGADNAGRMFDVTTGQATQVAQHDAPIRIVRWIESPQGSVLATGSWDKTIKYWDLRTPNPVSTVNLPERCYTMDVVYPLMVVGTAERHIQVFNLQNPTTPFKTLTSPLKWQTRVVSCFPSANGFAVGSIEGRVAIQYVEEKDASNNFSFKCHRRDQTPSAKDQSLVYAVNDISFHPVHGTFSTCGSDGTINFWDKDARTRLKSFDPAPGPVPCSTFNRAGTIFAYAVSYDWSKGHSGMTPGHPNKLMLHACKDDEVKRKPQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q713</accession>
    <name>A0A4Q9Q713_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_869792</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q713"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="213"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="143"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="270"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="512"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="580"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU63179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="852" mass="93086" checksum="9017EAE1986FEBA7" modified="2019-07-31" version="1">MPSASSKPARPIERSYSNPVPRKRRAVKRRGRTQDEFESDEEIVREVRTDSETDDDNSSIDSDSDSESTSSDLHADVHSEVVTPSTTQSPPPVELDRLANGGVKDPSSSQAGIFADTTNWAEMVAGEAENGAADLPVIDFADMASNHLPEPRAPSPAHRSRKSHKAVKKSAAARATSAPPPAALTSQEEPAEEQFQEQGPVASTSDEPHPHSALPSRSRGQTARQAYQQRLESDPSFVPKVGEFWGHDDRLLDKDLRSLSGWWRGRWQSRGRGRGAFSMRGRGRSGFFPSRSSPRDESVAPEESADVPPVERPWTHDGFEEMKRRDERRRALQEQQQANAVLQRGFGFRGRGFVPARGRGGAFARGGSPTATQRPLTSNVSMGDRVWYAQKPERMWTKQHDIFLYNDAATKPRPGVGPGVRVKLPGGKVPLIVRLPPRTSTARASDKPEETPSPSLDAEKPIIVRMPAAFGKTKVVEEVPVASAGGEELATTVEELSIEEVFTVRPNAVPNRRIDFSVPSPSVPTAHAPQAVSGQSKTPSPQLSQPAEVDAHNPIEQLSILPIDGGASSPSVQIQETILRNPLPSEDTNLSPSVTAPGEESQSRPEPPILHPLQTSFSPVPPPTSPPYGSPYGYAPALPPGVGVNSQGMAYEYATGRAVYIQPTPPPMYTPRPMMHGHHPSMSIPFVPSHLRHHSAASPDFLAHPHTPHTHTPIQSFVDPTTGVPIFSPARQSSRIEIRAPTEAAESKKPTRASHQRSNLSVAYPAEGPYYPQQDLSVEDVGATDEALSQPPMGHAHTPSMESIGYAPYPQPYYYPEQYGYPPYVDMSGQMMQYEMYPPEHQHHPSQPVVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q722</accession>
    <name>A0A4Q9Q722_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribonuclease III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_621235</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q722"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q722"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF0">
        <property type="entry name" value="RIBONUCLEASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="7">
        <location>
            <begin position="55"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="6">
        <location>
            <begin position="266"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="348" mass="38481" checksum="0E46C9A5AC18F70A" modified="2019-07-31" version="1">MASAANGPGLPRIFLPSGRTPIKPEFPNGLPPLPDIQSEQLRLQVFTHRSFFARPTHIFEDMPDDPSPDNEMWAPLLLLRRVASKSPDVRSDHRLEHLGDTVLNLVVTGLLREVYPCLRVGPSTKIRALIVGNPTLASISVQYRLPERLRMHPAQAITLQASTNIQADLFESFVGGVYLDRGLEVTKTWLHPLFRPYIVEAYRIVRVQHGLPPDPVPPYPLLHSAYRHVSLTPPMRGSGVATPDNSGIPASSWSIPPPPRIPGNVGHLSLFNQHMQQQGKFVEWVYTDSEGEGTKTTPIWVVRAMCEGECLGRGRGSTKKAARNEAAKEGLVHLGIYISQPEGFYAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8F3</accession>
    <name>A0A4Q9Q8F3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="8">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Eukaryotic translation initiation factor 3 90 kDa subunit homolog</fullName>
            <shortName evidence="8">eIF3 p90</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF3, p90 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">PRT1</name>
        <name evidence="11" type="ORF">BD310DRAFT_964983</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="8">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the eIF-3 subunit B family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU63291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="EIF3B"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
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    </dbReference>
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        <property type="entry name" value="RNA-binding domain, RBD"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="3 8 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7 8 9" id="KW-0648">Protein biosynthesis</keyword>
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    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
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            <end position="722"/>
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    </feature>
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            <begin position="699"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="740" mass="85870" checksum="3A8815896EEF369F" modified="2019-07-31" version="1">MAHNGVNGTIYDDEDIDYSDIEAKYQVEYDESFDNILVVDGVPVIDKSKLEKLLQKISKDFSRKGCPIKPENMTVPWNESNGKSKGYIFMEFKNPDDASRALAAMNGHPFDARHTFLINRFTDFERYLNLDETYVEPPPEEYKPKEHLRAWLGDPQGRDQYATYRGDDVEIHWHGKPSQCEVAYSKPNWTDLYVSWSPMGTYFASLHRQGVRLWGGPSWEPQSRFAHPLVKLIDFSPNEQYLVTWSYDPIVVREGAEQGPQYFAPEDEGNNIAVWDIKTGHLLRTFPSVYPEGDDQKKQMAWPALKWSPDDKYVARVTPGQQISVYELPGMGLQGKKSIKIEGVVDFEWRPLGDRDREEIEKENQAGSGKTPKKARENMLAFWTPEVQNQPARVSLMSFPSRETLRQKNLFNVSECKLYWQNQGDFLCVKVDRHTKTKKSIFCNLEIFRVREKDFPVEVVELKDTVTDFSWEPKGERFALVSSSDPNLGNPGPGITIKTDVSFYQHERSKGDFKLLKSLPGRTSNTVRWSPRGRHVVLATVGSSSKSELEFWDLDFSVDETRREGAPWGSGIQHLGTADHYALTDAEWDPSGRYIATSASAWRHTLENGYAIWDFRGQELEKHILDRFKQFLWRPRPPSLLTKEQQKQIRRNLKEYSRVFDEEDAAEESNVSAELIAHRKRLIDEWNAWRQRCREEVAEERRKRGKKVEPAKEKQPQEEQEEIEVWVDEVIEQIEEEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8K5</accession>
    <name>A0A4Q9Q8K5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_841095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8K5"/>
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            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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            <begin position="522"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        <location>
            <begin position="753"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
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        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
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        <location>
            <begin position="231"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
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        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
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            <begin position="401"/>
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        </location>
    </feature>
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            <begin position="412"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="576"/>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="772"/>
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        </location>
    </feature>
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        <location>
            <begin position="797"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="825"/>
            <end position="839"/>
        </location>
    </feature>
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        <location>
            <begin position="877"/>
            <end position="886"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="958"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1043" mass="111505" checksum="7F14ECA26FC9E8A2" modified="2019-07-31" version="1">MRPAVQSNAPSRPWWSRSKSSKDPLHPSRAPSGLGDEDEKYPSTTSSTSSKPKDAIPALKFNTLASAIGFKSKKLPSLTIQDPPSPLPPSHYAKSRPGSGNSGVASPAPVDRAPFYTNRPPAKSVSTVRSSEYDFDAASEPHSEPRTPSDHPRDRFSYQHSVMTFSEVDPFASGGIIMHPMPQDPNRLSVYSDSSMLDPQHKRPDIPPPMTNRVSYGSSSSNSHGNYSDSQVLSPLSTSSFARSPTASRSAHDLTQTNDQYYANGPASPPLQAHRTRRTKTPSGSNSSNSTVTQNDFRSRLSEPPSGVGMHIARKRSSPALGRPRGATVGAIDHPPSHPPAIPNLGQPTPPLQPRRKESGSSSPSSSNTPSPSPVVFSRQRTTSTTSNFPVSPSSPRPPLSRKASSSRLPASPAPAPPTSGLPPTPSHHPPLPSSPYGLSPLEFRASSSSSSLNFAPSVDLHDLDDDDPISQLLNGHYDLGPFEATVREPPKGKARKNRNTYILDGDLSPIAGDVDSSLPSPLSKFPPVPTAIHGDISPKAAKLLKKMSSQQNFSQRHSATSLNSTVSGPPDDVNSHGSGHAPAHAAKTPRKQRSFHTPRGIPRPFPGLRSSSNHPSASADPLPTPSSPIVEPRRGNVASPRKRLFSGSSTRRSTSSHGPAVPADVDDKRSVFSFESDTRPSSSSGVEAITMSFGTAGGGLSFMTRNACISPSSIWEDGSQSRGSEDKRLSQTEYVPQYIMSPAEQIKLAEKLEDEEPDTSVRAVPEPEPEYSGRKPMLDLHPGDFGLTYSPLPGASRSRSNSVLSSQSTGTLAFGDKVGLNRGPSILSSKTSISSRPSPTKPSPQKAALMDLVRGGPTRAASVLTKPLNKPPPLSTRPSTSQGPLSTPPASPAGFTSATHSPEIPAASLPPPPRRRPSRYDLNEVEQTTSHRASVVPMNPLSPPPMRPMKSRRQESTDTTTTVGSRPPSSFDRQKNIARRSLMKKPSFLDIEDEFDLSAENGSDKEVESAPESPTMEDSFLDMDRGKSSFDTVRSMDSAFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8N9</accession>
    <name>A0A4Q9Q8N9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_916688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8N9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021030549" evidence="1">
        <location>
            <begin position="20"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14627" checksum="69C749E4ACF4991B" modified="2019-07-31" version="1">MPWLFFNTTSLCLPWKLLSSLFSGECVDSRDIQQLTVTHGLAGLWPRRHPAICSSPQAFSQILCLSLLSAFLETGYIILHKLGAATSSAPQVAGTDRPPFRVHVSFPILPPALVYRIHMVPQRSRRCDRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9K1</accession>
    <name>A0A4Q9Q9K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9K1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19101">
        <property type="entry name" value="AKR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147:SF2">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43147">
        <property type="entry name" value="PROTEIN TAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="343" mass="38698" checksum="4A68BA6CB048CCC8" modified="2019-07-31" version="1">MVVIFDSALRGETFRLGNHDLPRLFNGLWQLSSNSWGSAPAAKIRRQMAIYAENGYTAFADHYGPAEILFGEFREKWSDPQEIFGATKWCVFRTVEPTRALVEEAVDDRLARMQSHRIDLLQFHWQDYDDTRYLKALHHLKDLQGEGKIGLIGLCNFNSAVMDEICTELGSGTIVSNQVQFSLIDVRPLYAMAEVCNRHNVKLLTYGTLCGGFLADAWLGKEEPDLYSGSLTPSQRKYLDMITRAWGSWSLFQDLLKELRAIADKYDGMSIANVATRWVLDHPFVGAVIIGVRMGVSEHTDDNQKVYSFRLDGDDRVKIEAVLARSNGAQLINSIGDCGAEYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAK8</accession>
    <name>A0A4Q9QAK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_964597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAK8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAK8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="2">
        <location>
            <begin position="361"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1006" mass="108418" checksum="D181404FB71041D2" modified="2019-07-31" version="1">MRLHLPTCDDTIMSRNDELCMVINAPTPRYDRPTMRSTSGAPHRLPSFFHSPRTFPNLAPSHSTCVEQFQDRTTQPAAEHDHQAPDDLSKSDPVESSPRVYSYSECPIRDSGFSRHDSLFSFGASSTRNAAELKSLLGSSSSRLRRGATVLSRHTHSMDKDTRKAHAVSLEQAKPRARVEVDIVLESDCVVEGGYLRGNIKIRVRKRQKKEAPVLLADGRVRIIGFECAAGDRHQHTFYQRASALSAITDAHTRLYDSPPDEEGFARAMEGVHILPFAMHLPNDGNFGSAKGTVSIQSGVALRYIAMISVKVKDSKTSKRSIAHFYRDCQVWPRLQVDGVLASAPRPIQASTARSISVIGGGNKLKLTAMLHRLTWIAGQRCYVRICIGNETKKTVKTVTLSLVRTTSLFKSNPEPDDHAALGKDICQTTVTHKIVAETTLERSSPATKNHASAEGWWTGVQALQEVYFSHHILLPPDALSVPRSRLLEVGYSIRVTASAGALTSDVHVTLPIHIINFLSVDPPPSEPLLSLDGSYTRLIPLEQSSGPPAACTLAAANPAPFREDSNPHVDDTARPPYKPSSSAPSPAPMQQHFATSIRARPHTITTHTPTHTAVDRSPSRFTAGVHGDTSETIGAPQPRAREPTAPSASESDTSMYSADSYMSTASLSSPQGYDHAAPYSPGRDLGNLELDEDADSSDEICSIVDAAQRDRSAERPGGYADTVSRHFITGHEDLGAGERYQRGDHTLNDPNTDGVAQPLSSQHIEVHPGPRVHREVQHSSSCRSPQRMSQLCPDVGLSSDASRTVLGAATPPTRPSVPIQGRDVVLGQSSSFRESAGPGVPRPRLAKDDDNHADKDKDEDEDGATTPTLRPTQSTAAPATLGVRLEGLPVSSATPTSGPQLQHRPSRALPKPPARALRVVDVPATVSALDALRSVANATASGLPAAPSDLFGTSFVNAPSTATSRSPTALRTSVAPRSSCLENGRRSLVGAIPVNVQQRFPPPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBD2</accession>
    <name>A0A4Q9QBD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_296696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBD2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="108" mass="12233" checksum="CA7B04D91C8620D7" modified="2019-07-31" version="1">MHIGECVLLMSCCRASSKPGQHRPCHQYDQRSLLSGRYVVRREDKLVWAAARVCEIVRGLTVLDRPPASRDQCIWRPPILGTPFTSDDGRLPYHATIATALSVHIWHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC18</accession>
    <name>A0A4Q9QC18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC18"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5784" checksum="F9DB86A1C577CFD1" modified="2019-07-31" version="1" fragment="single">QLGRRCHITDCMPCPPTSAAVAENEFDPEIQPDCAWKKCKRCTAAHTCCSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC23</accession>
    <name>A0A4Q9QC23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanine nucleotide-binding protein subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_803952</name>
        <name evidence="12" type="ORF">BD311DRAFT_743981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">G proteins are composed of 3 units, alpha, beta and gamma.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G protein gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC23"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC23"/>
    <dbReference type="OMA" id="NGCCAVM"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031681">
        <property type="term" value="F:G-protein beta-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.260.10:FF:000003">
        <property type="entry name" value="G-protein complex gamma subunit Ste18/GpgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.260.10">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015898">
        <property type="entry name" value="G-protein_gamma-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036284">
        <property type="entry name" value="GGL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041848">
        <property type="entry name" value="Ste18_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28189:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00631">
        <property type="entry name" value="G-gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01224">
        <property type="entry name" value="G_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48670">
        <property type="entry name" value="Transducin (heterotrimeric G protein), gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50058">
        <property type="entry name" value="G_PROTEIN_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="G protein gamma" evidence="11">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU35437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU65277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9102" checksum="3809C62B6CE49F69" modified="2019-07-31" version="1">MSGRPPKQSMSELKLRRLSEHNARLREDLARPRIRVSEASKSLINYCKSTPDHLIPSVWGPVSKAEDPFAVPNQGCQCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCN3</accession>
    <name>A0A4Q9QCN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_983677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCN3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="281" mass="31434" checksum="EC657EA22FB097CD" modified="2019-07-31" version="1">MLYRDILGGQVELRNPREHLSALFAGSLTTVSGLVVCLDADYHWWIKLLGWMVSCDLFADAKHAELRKESRFPSKAGQSDYCPPPDHTTNSAQPKHTSVPLSSLFLNTLHDEFPVLSLDCVPYRHLESHIRHLQAALAPGAFLVLGLTSRPANASFWSPSTILTAVPFFPRCFLNDRDQQHSPAQRTTTPLFTSILSVLQLLTTGPNMLTVEVARNVSREYAHFLHGSVDRLENDPYTRAAFVRQWGMKAWAEERLCTAWEAGLLDAGLLEGWAIVVCKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCT9</accession>
    <name>A0A4Q9QCT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_303317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8516" checksum="63943BB3ADF7A69C" modified="2019-07-31" version="1">MLTVSLAWCNLNVRALLSQGSTTVGAVLRTVASSAFAKSRVADGIEIALECIVQFSLSNCAPFTFRESCASALESIRVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD54</accession>
    <name>A0A4Q9QD54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Non-structural maintenance of chromosomes element 1 homolog</fullName>
            <ecNumber evidence="4 16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_864677</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the Smc5-Smc6 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the NSE1 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4 16"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD54"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD54"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="WH-like_DNA-bd_sf"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NON-STRUCTURAL MAINTENANCE OF CHROMOSOMES ELEMENT 1 HOMOLOG"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="zf-RING-like"/>
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="196"/>
            <end position="237"/>
        </location>
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            <begin position="254"/>
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        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU65707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="347" mass="39022" checksum="6BB5BA89BD0FCCA8" modified="2019-07-31" version="1">MPVSSNDVQRLFLQAILSRRILSQKLAAKIWEKCIDAVKAANDTLDIQYRADRNSWDNFVTSINDALNPLDLEFAHLHDEVTGQEVYAVVNRKGDEIAQMATDYSALEIAYFKAVLEQIMLAPNESFCVSSLAALREVNSLKSNMTKSQAEATLHSFVAKGWLVKSRRGRYSLSTRTILELQTYLRTTYESEIIECTICMELVTRGVGCPTPQCKTRLHNHCFANYRRRNNACPTCKEAWSEGNGAKLRPVGEAAFKEGQDQGRRRARRKSTEEQEDGDEEGEHDASQEQDDDAMNGEPDPSQSQSVPPQTQPNGRGKGKRRAVLEEVEDDGTPPPRTQPRRSSRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD86</accession>
    <name>A0A4Q9QD86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_954540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU65071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13679" checksum="A7EC2BD4A9FDD99D" modified="2019-07-31" version="1">MHEACPVSRQIVNAAVERHCGDVLPWCSKVRWHIQRATRGVSPYRHTAQTNHRLTRMRAADLDTPSKKGSERGTDPRLPERQCTTLGSIEHLARVTFASNGKSTRAHMSKSLGMSISSESASGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDM6</accession>
    <name>A0A4Q9QDM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_865063</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
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    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU65887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9QDM6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020183914" evidence="15">
        <location>
            <begin position="31"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU65887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="535" mass="60159" checksum="495B5E7906950B23" modified="2019-07-31" version="1">MDGSSAIALLVSAWSCSLILLFVKFQQSAASLRPGRLPPGPTPLPLIGNLLDIPRVRPWLGFNDMAKKYGNLMHFRALGRSIIIINDPDTVMDLFEKRSTVYLSRPQTILSSLYVSQIAHAPFEQCNHVVAFRTGWEWNMAFFPYGPKWKHYRRAVWAYYHPDVIAKYYPCQTENARRLLSKLLSDDTRLVEHVRSAIGATLVTITYGVDVTMDSSDTLLSTFEEGVKSIQLFVSGSSVLEFIPILSRLPTWLPGTAYLRDLARTRQATYRMRDVPWNAAKEALSEGRASESIARSMVERLSHLSDDVDLGEEMVARDVSAISYAAGIDTTHAVLCNFFVAMALYPDVQKAAQAELDAIVGQSRLPEFEDRDNLPYINAIIKETLRWHPAAPLGLAHRSTEDDIHEGYFIPEGSIVMVNVWSIMNDPAVYPEPEKFIPERFFKEGRIDAAVRDPFAYLFGFGPRICPGRHYADASLFITIASVLHTLNIHPPRDSNGQPIQTELRTTSGLVVHIDNYRCTVTPRSATEELIRNLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE42</accession>
    <name>A0A4Q9QE42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_838757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QE42"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1190"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="299"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="471"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="585"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="749"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="970"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1263"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="349"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="601"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="652"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="775"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="822"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="881"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="923"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="990"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1153"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1282" mass="138270" checksum="F75FC43040826940" modified="2019-07-31" version="1">MDGSRPGEAGVIAWCNSIRFTMAKDPGRQFLYEQIQKEGFDFLDMYLENFLDGPTKEPVIELLKTPGRKKNTAIKTRAATAAAAKVKAVTSMSFEDGEAKENHAPLNNFHKALLQAKEGSNSTQEKWSSHQLSAERSLSNKSLAKVKDQRIVTIADSPAVQASDAVMDVDEVHKPIPAPTFSVVQPVAQVASQGASLEVPVNATNELSMIVEDDELAERSRVSLDIPLSAKPAAVEIDPEPGRPNETRDVFHDAEEAVSDDVLMQDDIADDADMSMADDEQPPQGDVTSASVATFHTIPLSPRREPELAQQSAHTADFHTAPLPRVSLSPIPVEEELHSHTAPLPASSSKHEEYTMPLREEPSAPVPGLSRKPSVAQFTGLPAPSPLRKSLRPPGDASAGSSTGATAAPALGKRTSTSWLSKARETKALETTSKRKSTLDPGIGTFAANKRKSSEMLEAANAVLRSLDEEERATKVPKLANSPAGDDNADKGKGKGKAPSLDTVFHAAPAQPTTSAEIVGVATTAPTSATDVLAEQDDMLATILKKNYEARTGKSMGKSLGGNAAAALAEARAAAEARVAERHKLELGDVSMTSEEKKSSSVDTQTAPTDPTESERRLSVSDLIPSSEGRSKPKAKQDTAQARQPTPPGADTSASTTPPNSPPRSRNTSFVAHTGPVFSKPPAQAPAPSARTESSAPAAIRDYKLPTENPFSIPAAMALGMGMKFQPLSAQSSKASVFSDVVLDRTNASPAWMPSTQDTSYSAAQSQSQPKGVVDDNDDDDDDNELDADDSWGVDEKFASNQMWTPFGFQSANPDQLKDDTMTWSTIPSRSTSQKGGDTQATQSLFPTEEVDEEEEEEREEPEPERGFAERLAAADQQPSDVEDGAVGEGDMAMEIDEDDAEEKVEEEEDFDEAVLAGKSTIKLVQQKSDTSSQPRSDSQQSMASTASSQSNLGLFGQASKLVSSVFGGGAKKAKPEVKSLQLAAAAAKKQQEEQEKKAHRLKEMEARRQQAIQRKAEEEKARQIEEERKIKEETERRKREREEHTDKRPLSRAATAPKKNEDDTSKRKVAATTSQKPPSKEKKDAVPPRTLKPSVGASSKPVLKSALKQPTAGPSGSSVPVTPGASKVPAQKTVKHMPSSSNLKVPPPAASKGKEKDTAEPLRSKTPTGHPPPAQEPPRVASESIELPDINSEYSDSEDEDRPKRDLPDWAKSPDIAAALQQQSTINPDDIFGQIRPLRMEEIFRTRHSRFRARTSSANWTGTDELTQEEEREYARRMGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFA6</accession>
    <name>A0A4Q9QFA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="4">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_836418</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="4"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFA6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFA6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000013">
        <property type="entry name" value="Proteasome subunit beta type-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="304"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU65544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="335" mass="36467" checksum="8F129509E13BAEE8" modified="2019-07-31" version="1">MNSFLTRYSSTSPEADIRKAKELFDEDGDVSDVMWGSASGFGNLASGVPMFKLPSVPDPTSFLRMHTDDHADPSCRIKIKHGTTTLAFRFQGGVIVAVDSRATAGSYVASGTVKKVIEINPYLLGTMAGGAADCQYWETYLGIQCRLHELRNRERISVAAASKYLSNLVYSYKGMGLSMGTMICGWDKTVRIPEMNRDCTEAIRANCRLQGPAIFYVDSDGSRLKGDLFSVGSGSTFAYGVLDQGYRWDLTDAEAQELGRRSIYAAGHRDAFSGNTVNLYHVKQDGWQFIGNYDVSKLHYEGPGDVPGAPGTGYGYDLRVAGRTSSDAPQSEGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JZN9</accession>
    <name>A0A4V2JZN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA-binding protein VTS1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">RNA-binding protein vts1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_929468</name>
        <name evidence="15" type="ORF">BD311DRAFT_741152</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA-binding protein involved in post-transcriptional regulation through transcript degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143460">
        <property type="protein sequence ID" value="TBU25513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JZN9"/>
    <dbReference type="STRING" id="114155.A0A4V2JZN9"/>
    <dbReference type="OMA" id="MSTVNNR"/>
    <dbReference type="OrthoDB" id="2155283at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09556">
        <property type="entry name" value="SAM_VTS1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000033">
        <property type="entry name" value="Protein vts1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050897">
        <property type="entry name" value="SMAUG/VTS1_RNA-bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057327">
        <property type="entry name" value="Vts1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037635">
        <property type="entry name" value="VTS1_SAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515:SF5">
        <property type="entry name" value="PROTEIN SMAUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12515">
        <property type="entry name" value="STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25479">
        <property type="entry name" value="Vts1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SAM" evidence="14">
        <location>
            <begin position="563"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="183"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="246"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="356"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="530"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU25513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU57325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="638" mass="65994" checksum="8A694D6E2F07425C" modified="2019-07-31" version="1">MSSLAPPSPSVSPAPGGNPGGRSPNFRASMGPTSARPVGAQGGLSPASPRPGATNGGARPTSELLGGAGMFQTPEAEAIDQWFETFQNYEVTLEEMAAASLDVNFKEELSAIEQWFKVLSEAERTAALYSLLQHSTQVQIRFFITVLQQMARSDPMTALLSPAVGGSMQSQMEAKLASMSLKSPGLKSNLPGSPTTRNFSGSGIGGGNSFLSPESANNASEAAATLAQQRAKLKASNAAHRISAPVLSSVGGDRNTWGSGSNQLGQVDERSSSPAQEITISPNPSSRPKSTDFSGLANALKSPRGDEGDQLSPMPGGSWASMVNTPLIPIFKDTRNPSQSLDAAAQKLNDWTAGGGGAVPLISDPPKKYTRPSKGAQNTDSDDNHGQNGSGQRNFSGGLRNVSGNGGFNGFGGQAGWAGARSPALSNASGRFSDDGSMNGLGMAGFGAMGMANPALAGLPGTGGFNMAALAAAGMAPVSPFNSMFNVSNLAAMGVTPEQMLAMQMAAAGQLGQLGQPGLNAFGMGMGNNANMRGNRGLGNRGGNNKSPSQRGEKKDDEDVDPKLLEDIPAWLRSLRLHKYTPNFEGVNWRDMVMMDEAQLEAKGVAALGARRKMLKTFEIVRKKMGIEEPAGAAASSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K387</accession>
    <name>A0A4V2K387_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_924641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K387"/>
    <dbReference type="OMA" id="FGMTVFI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="496" mass="56072" checksum="521D690275DC8BAC" modified="2019-07-31" version="1">MPQPEFIDDPEKAVLDTLTPLPVLPVSSKAVIQDAAVGLAAQSGKDERPEFALAKAKKDAAASNKPRRRVSGWVRFSLWFTTYRKFFIFVVTLNGVGLFLAALNIWTYPRRYTGAFVLGNLLFAILMRNELFGRLSYLFVNKAFAKWTPLWWRLGCTSVLQHLGGIHSGCASSGFAWLIFRVTLIFIDHKDNHDAVLIMGVITNLAVSISILSAFPWVRNTHHNVFERHHRFIGWLGLLSTWVFVVLGDSYDLDTHSWNPDGVRVIRQQDFWYAFGMTVFILIPWFTVREVKVDIEVPSPKVAILRFERGMQQGLISRVSRSSVMEYHAFGIISEGTHAKYHYLICGVQGDFTRSLVNDPPTHLWTRQLKFAGVSHTSTLYKRGIRVCTGTGLGAALSTCLQNPDWYLIWIGSDQEKTFGPTISGLIHKHIEPERMCLWDSRARGGRPDVMQLIKDAYKSWGAEVVFITSNWQGNKEIMEGCKAAGIPAMGTLWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7S8</accession>
    <name>A0A4V2K7S8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_822038</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7S8"/>
    <dbReference type="STRING" id="114155.A0A4V2K7S8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="3"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="292"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="434" mass="47629" checksum="DF55DE6A97AFD9DC" modified="2019-07-31" version="1">MGGLVLGLCLKKYASDVRFDIYESAAKLTEVGAGVALSPRIWTIMQELGLEEELVKVTGAVDRAGSDLLFRKGDEAKVIDIVRFHQLHMFHRSMLQRILAEKLDATDRIHFSKRLTSYSEPTSPTEPIVLNFKDGTTATCDIVIGSDGIRSSVRRTMFANLSDESERHGRIEEASRFRAMVEPIWSGHVTYRGLVPASDLSEELRQFASTPQILCGKDRHIVLYPVSGGELVNVVSSVYTLGSGTVYDGPWVETTTSEKVAKLCEGFIPNGVALIKSMREPLCWALHTVPKLTTYIKGRSALIGDAAHAMVPFQGAGLGQAIEDGFVLANILAHSSVALANVSEALKIYDDVRRPFSQTVQQGSECTGELYQLRRAGWENISVEDSAAGRYPPELLSDFEKDAKAQMEWQYDPGASIKGDIAKVLSMLETLSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7Z1</accession>
    <name>A0A4V2K7Z1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_977803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7Z1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="462" mass="49999" checksum="032B3346495DA982" modified="2019-07-31" version="1">MGNQKNKKNQNLRKTSSSTRRHRPPPPPLSPSPPKVGPKPRPKVKKNAVASSAFTPHLPAPIPAPPPSPRLEEGELETATILARLRTYRPPAAHGLRSSAASNASGHSTTSTSPQVQDPPVIEVSSDDDGSRAEVEDPEGEDDNVEDEEEETEEGSVDVPLSQVVKAMADGEEDSSSDDEEEFNRLAEEIRKRSHEYVAREREAKEKAEAEDQVLWEQEFAKFASLAKQSAKAEKRRSAKLNLQLVYTLPWYKKGVLPDALENAGDWATLTSRVAKHIEYEKSCGRGVVKDFSIKVWSEDAVQTGAALLELPGKKRGDRIRVRALPYDNGAAVKIEAMHYCAKCSGACVIGPDGRHHAIPVDLMAKWVNAVDKPNTGVTKDKVPNFVCKALNIHTVSAVDTSPPKSGPLMSTPNTVHAQAPPVPATIPSAPAAISPSMPAFFPTPMPMQTPVGYGYAPNSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8S9</accession>
    <name>A0A4V2K8S9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_921686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8S9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25823" checksum="EF8EF3685ADEA397" modified="2019-07-31" version="1">MAGYFAFPPPGSAAAPSTFRQTLGDTDVNALHSSESQRQPQERSQYAEQKTETQAQARAQRQQLEREQIRLGEMEWVRAGGWLRDASGRKDKARTEQVRAEVRLVDEERKTLERWDAYEARWNALLSSTTPVTFADMPWPASPPPSSAEDLASDVISEFFLGPLLVRSSTVVMKDRIRTSILRWHPDKLSAIVSRTVEGDLDSVRAGINTVFHVLRSLQDLERSMDIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9L4</accession>
    <name>A0A4V2K9L4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13 14">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 13 14">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_914538</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 13 14"/>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9L4"/>
    <dbReference type="STRING" id="114155.A0A4V2K9L4"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 13 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 14" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="16">
        <location>
            <begin position="10"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="15">
        <location>
            <begin position="195"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU64378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="400" mass="43499" checksum="B9780182D35D885A" modified="2019-07-31" version="1">MTVYQATASAPVNIACIKYWGKRDTKLILPTNSSLSVTLDQDHLRSTTTSRADPSFQQDRLWLNGTEDEIKEGGRLATCIREMKALRKQLEDKDSSLPKISDYHVHISSRNNFPTAAGLASSASGFAALVASLAALYQLPTSRSDLSRIARQGSGSACRSLFGGFVAWQKGERADGSDSLAVEVAPREHWPDIHALICVVNDEKKGTSSTSGMQRTVETSPLLQHRIKHVVPERMAAISKAILARDFDTFARITMQDSNQFHAVALDTEPPIFYMNDVSRAIIALIVEYNRVAVEKGGKLKAAYTYDAGPNAVIYAPKENIKEIVELIVKYFPQAENFKDPFGLFGAAGVQGKVVEGFNEAVAKPFSVGAVKGLIHTRVGDGPRTLGPEEALLGPEGLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MMI2</accession>
    <name>A0A4Q9MMI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_935060</name>
        <name evidence="9" type="ORF">BD311DRAFT_796942</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143418">
        <property type="protein sequence ID" value="TBU28809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MMI2"/>
    <dbReference type="STRING" id="114155.A0A4Q9MMI2"/>
    <dbReference type="OMA" id="HFRSYHP"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="76"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00065857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU28809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU54775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="241" mass="26476" checksum="A1BEDE27430B1E4E" modified="2019-07-31" version="1">MFSRSPRSAISAAQRAARLQSTIAIPAASSASSSANTPALPPQRLTEAQYAASVVHGRSVRPPFYLPKTHGIPVATLHFRSYHPKLLDFFVHFASHAATALGIPISKPVHLPTERRLWTVLRGPFVHKKSQENFERRTHKRVVKAWDANPEVVDLLVQYLERHIAPGVGLRTVQWRRAPVGVGQKTLEAVMGSLRLDDQVRREKVKALGEQIVKQELASAAEAAKEGAVAKTSPKADKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MZB5</accession>
    <name>A0A4Q9MZB5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7719 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_926366</name>
        <name evidence="4" type="ORF">BD311DRAFT_751404</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MZB5"/>
    <dbReference type="OrthoDB" id="5597489at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056136">
        <property type="entry name" value="DUF7719"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846:SF1">
        <property type="entry name" value="DEACETYLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37846">
        <property type="entry name" value="YALI0B21296P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24841">
        <property type="entry name" value="DUF7719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7719" evidence="3">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU32152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU58706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="198" mass="22791" checksum="BE21F0A9667872D2" modified="2019-07-31" version="1">MARNRKNHDRPTAEAGQTIDIPEHEQWRIIKESGVLKQIPQDPKSTTVNERAEDEEEGLSPFAEEVFNSMMLVIPMSFMLLLMEILVHFQYGRQPDYLAIFKDRMLASVPIISVFIFYSNRYKSHLYMQAGFFVLACIVGPRLVWLINRGNWLVVMRQSPPLATAWIYAIVQLNLLPAALNLIIVLGFGWYKGLKLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N503</accession>
    <name>A0A4Q9N503_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small COPII coat GTPase SAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Small COPII coat GTPase sar1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD310DRAFT_836480</name>
        <name evidence="22" type="ORF">BD311DRAFT_680262</name>
    </gene>
    <organism evidence="22">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 464.89</strain>
            <strain evidence="22">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 21">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N503"/>
    <dbReference type="STRING" id="114155.A0A4Q9N503"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
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        <location>
            <begin position="27"/>
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        <location>
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    </evidence>
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        <source>
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            <dbReference type="EMBL" id="TBU35724.1"/>
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            <dbReference type="EMBL" id="TBU65571.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="189" mass="21493" checksum="B607AE84BD062750" modified="2019-07-31" version="1">MFIINWFWDVLAQLGLLHKNAKILFLGLDNAGKTTLLHMLKNDRLATLQPTLHPTSEELAIGNVKFTTYDLGGHQQARRLWRDYFPEVDGIIFLVDSADFERFSESKAELDALLSIEELSKVPFLILGNKIDAPGAVSEDELRHQLGLYQTTGKGKVPLNDIRPIEIFMCSVVQRQGYGEGFRWLSQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NA31</accession>
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        <name evidence="2" type="ORF">BD310DRAFT_934160</name>
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        <name type="scientific">Dichomitus squalens</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR44924:SF1">
        <property type="entry name" value="DNAJ SUBFAMILY A MEMBER 2"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="214"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="480"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="221"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU55276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="480" mass="53031" checksum="27BF7782330AF9EC" modified="2019-07-31" version="1">MNATIQSRPLVPHIPTSCSQCSVPLEFPVPSPVPRSGTFLSVQCFNCHTVITHAFYPNQIPSQYHTQVNLAGPSGSGGSGGGASSSQAVRKGRKIGTQEKPLETGYYDLLGVSVDASTDDIKKAYRRLAIKFHPDKNPDDPHAEERFKEIAIAYQTLSDPALRRKYNEFGSKESAPDGGFVDPEEIFGTIFGGERFVPIIGHISLAKDMKAALQEEGEGEEAPRDAKGREILSPEEKAKRDEKAKKQAAEKAAARAERIQKLVENLDRKLSIFTESATSPTDPQVTESFRTICKLEAEELKQESYGVDLLHAIGFVYAQKGKQYLASNQTFLGMGGWLHNVQGKYHVFSETVSTLRAAMELKGVFEQIQAAEKAGNLSPEEKRRLEEQAAEKGLQALFKGTKLEIESVLRETCDRMLEDPSVPRAKVQLRAIALQILGEAYMSVVKDEDVTHEESEYVRVETKSSRKRDSYRPTPATPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCP2</accession>
    <name>A0A4Q9NCP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145288">
        <property type="protein sequence ID" value="TBU51754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCP2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="38609" checksum="7611B99988F9461C" modified="2019-07-31" version="1">MSVPEVVVSQEHISSSLSLGNGVELGYLDSGAPEKQVYTTIFAIHGMGYHSPVFRRVIALSPAVGVRFVAVTRRDYNGSTPYTAHELNALQNGSNSDKQAFLRARGLEIATFIQRFIQENSLPAPSSDEKTGGIGVLGWSLGASFAVALVANLQTYPTLIQKTLGQYLRALILQAAVCRPWPSLPPQSWSPQIDTSIPAQCRQTGFVQWITSYFEHGDLSTRDPNVLEYVLPTVKRVPSVFTMGQDELDEMTNIDAANGGDTLIVVSFSPQLRACYKDALYNKDIRAALPRMKVLVFSGDATANFGIVALWSIEDDDAAAGGGWVETKIVPGINHFVHWDAPQLAVETYLSVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NG18</accession>
    <name>A0A4Q9NG18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_951770</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="ML145201">
        <property type="protein sequence ID" value="TBU53962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NG18"/>
    <dbReference type="STRING" id="114155.A0A4Q9NG18"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 20" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="19">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU53962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="420" mass="45687" checksum="B1F3FD0A90DCE3B5" modified="2019-07-31" version="1">MLYNLLPTTLQLFLASLLWQPHSNAPSNRNLSFELRHQHALSNTSRVVFSDTLPDAAFTMDNIHVRTKKTTVFKPVSQALPQSTRFRGGNVPWDVSEVDGPDIEDRETLLLLAKMANNAYTEPGKSDWYDIGPNYNITYPFGWEPDADGFRGHIFSTPDNSTVVVSIKGTSIFWPIGAGGPTQTKDKLNDNLLFSCCCARVSRTWSTVCGCYEGEKRCDQGCLEKSLTEESLFYSVGINLYNNITYMYPDSNIWLIGHSLGGALASLVGVTFGVPVVAFEAPAERLAASRLHLPSPPSVQHVTHVYNTGDPIPMGTCTGIGSTCNTVGVALETRCHLGQTIKYDTVSQLGWSANIIHHGISALIEGVLADDKKDWRGNGVNGSVPEARPEEDCVDCFDWTFGDFRNASGVGAAGCGGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMA6</accession>
    <name>A0A4Q9NMA6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase/thiol ester dehydrase-isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_890189</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145277">
        <property type="protein sequence ID" value="TBU51900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMA6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="170"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="304" mass="32948" checksum="D6D8C2F0CD8BBE5B" modified="2019-07-31" version="1">MYSAHLRRQIGRASRAASARWSSTSTSSSASSAFWRNFRLLTGATTLAATSYYLGALYPPGFIHLLSPRPAPAPLHPEDPAAPAHIAELEEKLNHLPVLAAHRARPDKAEWYETRPYLNLPEERRVNSLTAGTLKGPGKLAIPPLVRARHDAKENWVFIHVGRALCGHEGVIHGGLLATLLDETLARVALLNLPEKVGVTANLNINYKAPTRADQFIVIKVRLDEAQGRKSRVSGVVEDMAGNVLVEANALFIQPRYAKLLNSTAVRHMLGEPSHSKEPITPGAVAPVPVKLPGGAEILVDTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NP91</accession>
    <name>A0A4Q9NP91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S2, flavodoxin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_865476</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NP91"/>
    <dbReference type="STRING" id="114155.A0A4Q9NP91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S2 PROKARYOTIC AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU66096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="305" mass="33653" checksum="CDEA4BD0FAB1F70E" modified="2019-07-31" version="1">MASLARSWTANAARCSRRTRFATSVLAQVRHNSFAKIEERPLETPDDWTEFQLKRAEYQTLIDTFSEYGSTQNRDNTFQPHHSLHRPVAPSDITLSALIASGAHFGHSETRMNPNFIPYAYGVRAGITIIDLDHTLPLLRRAAQVVRGVAARGGSIVFVGTRSDLRPAVRLAAERLGKQGYHVGERWLPGTLTNRVHMFGPDVAKDEQVVPDLVIFLNPIPNIHAIRECALEHVPTIGIVDSNVDPRVVMYPIPANDESTRTAELIAGLLSVAGREGVALYEEEQAKAALVAAKKGPRHREPHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPB3</accession>
    <name>A0A4Q9NPB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_806370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPB3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="7092" checksum="705821957D0132BF" modified="2019-07-31" version="1">MPLVTRDWLACVPSPNKSPNVQRTHPRKHTWRTVEVRQAPASEDSTSLTHVLHQLFTALFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPV0</accession>
    <name>A0A4Q9NPV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_810385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NPV0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043400142" evidence="2">
        <location>
            <begin position="23"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="434" mass="48889" checksum="C3BE4AB84AC0316D" modified="2019-07-31" version="1">MHGLSAFYLVAALTSCSSVGHSSKEITKEAKRRRIDDTASDEADDDTQPNTVSVVPAKTPPIEPKNPGWVVQAWNCNASANDKLRHSNGTEQMYDAARQIGRCSTEYPDQTRALTYGVIFRGFDAENRPDYCSDRYNDDVEARMIFLVWLRYFPELEDHLVYLAANPALILHLGNYVKAIAGRVRSDDLGRLNGSIVSYSMLEDPKNTLQRHSNRGFEDPRTGRLLCPVRILEEFEANPAHICSLYRDHIYKISSYDFPSFMTDLSLADPDDREAGFLRGPLLVSYYKAVFLGRSSVYSEPSSRGQPSVAVKYGMTEVNLHSIAYVTLLARSALGSDPVWRDADGKSWLAPSFLHAIMDLVCRSPSWKQSTIDWWNKQIFGTEDTDDSETERELEESDYYKIITQRAARESSKTPSTSEPPAQEHEVAERASDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRQ5</accession>
    <name>A0A4Q9NRQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_951884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145206">
        <property type="protein sequence ID" value="TBU53711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRQ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="154" mass="16210" checksum="BA55F64D22E1D916" modified="2019-07-31" version="1">MAQYAAQGQTASTHNMVHPSDLKSIGNDLDLDEGTDFVPESISSDEELIDFLVVSDDTFTPTLSPSHSSRVIQTAAAAGVTTYGYIFTDQHAAAADPPAGVQHASEIPYVYGAPAVTESDLGVGVLATSMTHYWISFAVSGTANDGKGLRRGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NS81</accession>
    <name>A0A4Q9NS81_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_839676</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NS81"/>
    <dbReference type="STRING" id="114155.A0A4Q9NS81"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000176">
        <property type="entry name" value="Isoleucine-tRNA ligase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="12">
        <location>
            <begin position="21"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="13">
        <location>
            <begin position="698"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU64522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1081" mass="124265" checksum="17342467C0999279" modified="2019-07-31" version="1">MSFPPHNLSAPFNFAKEEEKVIAYWREIDAFQTSLKLSEGKPEFTFYDGPPFATGLPHYGHLLAGTIKDIVTRHAHASGHHVIRRFGWDTHGLPVEHEIDKKLGITSRDDVMKMGLDKYNDECRAIVMRYASEWRHTVERMGRWIDFDNDYKTLNTSFMESVWWAFKQLHEKGQVYRGLRVMPYSTGCTTPLSNFEANLAYKDVNDPAVTVAFPLVDDRSTSLLAWTTTPWTLPSNLGLCVNPDFTYIKIHDEERDQNFIIYEGLLKTLYKDPKKAKFKKLASYKGVDMKGWRYVPLFEYFTEQFEDRAFRVLNDQYVKADEGTGIVHQAPAFGEDDHRIAIAHGVLRPEDMPPCPIDDAGRFTSQVPDFQGQHVKAADKEIQKVLKAKGRLIVQSTVNHSYPFCWRSGTPLIYRAIPAWFVRVQPIVDQLVANNSATRWVPQHVGDGRFGNWIANARDWNVSRNRYWGTPIPLWASEDMEEIVCVGSVEELETLSGVKGITDLHRDKIDHITIPSKKGKGQLKRVEEVFDCWFESGSMPYASNHYPFENKELFENTYPGDFVAEGIDQTRGWFYTLLVLGTHLFGKAPWKNLIVYGLVLAEDGRKMSKSLKNYPDPIHIINQYGADATRMFLVNSPIVRGDNLRFREAGVREVVSRVLLPWLNSFRFFLGQAALLQKTTGRRFVYHAHAKLSSNVMDRWILARCQSLIRLVREEMAAYRLYTIIPRLLDLVDELTNWYIRFNRRRLKGEDGEEDTVAALNTLFETLLTLCQTMSSYTPFLTENIYQGLREFIPEDPKAGDVRSIHFLPFPEVKEEYFDEVIERRVKRMQTVIELTRAVRERHNLSLKTPLQELLVFHADPQYLEDVKELERYVQSELNVRDIVFTSDEAAAGVKYRAVADWAVLGRKLRKDLGRVKNALPNVPSDDVRKYVETGKLTVDGIELVAGDLAVQRYIELPEQAQGGDAKHATNTDNEVVVRLDVTVHPELQTEYLAREFINRVQKLRKRAGLQATDDVDVYYAFEEGAGDDLRAAVEAYAETIQKTTRSVPRSVSERGTDRKVLTEEEQEIADVKFTLSLAWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUY7</accession>
    <name>A0A4Q9NUY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_915272</name>
        <name evidence="3" type="ORF">BD311DRAFT_714045</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUY7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NUY7"/>
    <dbReference type="OMA" id="FHYIVHC"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU32931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18040" checksum="7665CF4AC86EFF14" modified="2019-07-31" version="1">MPPQLKLNAVAFVSPQNHPILIRTFAQGQDELKYHYIAHTSLDVIDERIAAALASKSTDCYLNLLYTMEDVAVYGYITPLKVKIIIALALTDSVVRDADVITIFRALHTAYRQAVANPFLKVNAPIDGYNDHATLLQAGNSKWRAFRKRVDDIGKAVGAVGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVL4</accession>
    <name>A0A4Q9NVL4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_920001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVL4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NVL4"/>
    <dbReference type="OMA" id="QYVPPVW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="180"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="703" mass="77990" checksum="C391BF1EC6A351C8" modified="2019-07-31" version="1">MPSARTKKEPNSPTPPSDDPSPKDASENSKIKRKRQSQSCDACRARKVRCARDNPDDPKGSCKHCITLGIPCTYDYQPKKRGPPNLYLRRLQEAAAAAAAAQQENHSGSEHPQSPSSTSQSATSPTQAALSPSAPVPAFLEPPLNGLNGVPSVSALPPSRYPIAADGFHSQFPPLSMSVPSSFGNSRLPEHGMSNGLSARSPQRQDDSQPFGSPSDQFSTYPLHNWSYKQHQALSVLPPSAIPPLSYYYRPHRLEDVAPRDTMLLIIALFFDFVYPLTPCVHKPSFMADVHARREERDPLFFALVMSTVASTLVQVPRSYLPMERHAVRKLAQTCHEASRHISVASYDPPTSMHVVIRYFDCVYHFCEGHDATQHAAFGEAAHIAVTLRMHEESSYEGLDLIECEVRRRTFWLLFGADKSMSILLGRPICLRDEDTTCNFPRELDDEYITPSAYLPQPHGKTAIVSGLNYISRIFALLGEILVRIRVDKRSPPQGQFLTARLEEVQALHSRIVSALAHTPEPLRLKHAHSQSHLPAEYGGAGFRQAAFTEVKDFFDNPNASRANALNPFLVMQANLYVTQQLVRFVIEQYRDELITSLQGSVDEHRVAEDREAVASDLLNILHSIPIQSIATNGPSLVHKVRFVASTLLDAVRKAETAPASAARAHGYLWDFLSILSEIERNYLLDDDRDGTSNDPGMPLMGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW43</accession>
    <name>A0A4Q9NW43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_931254</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW43"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20396" checksum="042B3512D5C90B29" modified="2019-07-31" version="1">MFGAEFAKAEDLVNAARPVEYALSHRRTHRMFAGRRALSQFWSWPGPFGRFDAVPSSRCRCTNSAPCGCSLPPLADPLMQSLTDDVCLCDLPSGTLSARRARRAGLLAPRRTSRVCGGWPEDEFVLVELASLRVRSAIVKALACSRTSTKRLGTASTWPSQRTRRRMKHARARTHTIAARNPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWH1</accession>
    <name>A0A4Q9NWH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_975022</name>
        <name evidence="5" type="ORF">BD311DRAFT_784715</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWH1"/>
    <dbReference type="OrthoDB" id="7289984at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="25376" checksum="8BA18AEE63827727" modified="2019-07-31" version="1">MSSTTTYLITGASRGIGLALAARLLRDPTNLVVAAGRNPDKATALQALKDDPATKGQLHIVKIDVDDAASIRAAYEPVAQTVGEKGLDVLINNAGILLANDAPFTLDPAVMVPQFVTNVVGPTIVAQTFLPLVEKSRRKLIVNVSSSLGSIGIGFDKRYSSYSITKTALNMLTYKMKVERPDLTVVTLNPGWVKTDLGGSEAPLELDDVIPGIIDVLSKLKTEDSGTFVQYDGARVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZW8</accession>
    <name>A0A4Q9NZW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arl8a protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_919054</name>
        <name evidence="8" type="ORF">BD311DRAFT_758126</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143420">
        <property type="protein sequence ID" value="TBU28637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZW8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZW8"/>
    <dbReference type="OMA" id="FRNMWER"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04159">
        <property type="entry name" value="Arl10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001120">
        <property type="entry name" value="ADP-ribosylation factor family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044154">
        <property type="entry name" value="Arl8a/8b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45732:SF7">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597616" evidence="7">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU28637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="20189" checksum="976A5F20FA7504F0" modified="2019-07-31" version="1">MASFFSSLLQWFSGLFFSKAAEIAVVGLQASGKTSFVNVLGSGQWSEDVVPTVAFNLRKVRKGNVTLKIWDVAGQPRYRSIWERYCSGVDAVVFVVDSVDKEKFETARFELHQLLAQPSLSGVPLLVIGNKNDLEGHASVQELIKALQLDKITTRPVSCYSCSMKSQHNLDIVLQWLAGRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P093</accession>
    <name>A0A4Q9P093_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P093"/>
    <dbReference type="STRING" id="114155.A0A4Q9P093"/>
    <dbReference type="OMA" id="HFYTYSF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="283" mass="31490" checksum="ED75B50FF940A499" modified="2019-07-31" version="1">MEDKRAQGAGIPRPHVSHTLDASHALVTSPVLHPIALAVLRLTLATYALFVGLYQLIEEAVKEHDAGTFFSYFTHLSYIGLIAYMYAAGVQTLCYALNRRKGYPLQQWPRVLQHLHILLYSTITTYPMVVTVIFWALLSDSDTFSTTLNAWFNISEHAMNTGYALFEILLTNAGPSPWWHLPACVAMLACYLGVAYITHATQGFYTYSFLDPGKEHAKLAGYIIAVGVAECVAFVLARGLTWIRMRLSRRMSYASSSDTEVEPAIDEDWQEIGRPGSSVGYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P132</accession>
    <name>A0A4Q9P132_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">G-alpha-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_930104</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P132"/>
    <dbReference type="STRING" id="114155.A0A4Q9P132"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="432"/>
            <end position="435"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU57149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="522" mass="58593" checksum="A1ED98596A248848" modified="2019-07-31" version="1">MYSARRSNDPEDPLAAAIAPPPGESPEEKAARLRREEEAKRINDEIDEGLKQDRAAWKKHKSMFKLLLLGQSESGKSTTLKNFQLAFAPKAWKAERASWRAVIQLNLVRSINNILDVLSAEMSKSSNPTSPATSPALRPITTESSGAGGNASPSHTQFSHTHALLKLRLAPLRRVEADLKQLIGAATDEIGEESASTPPFSSAGAGASDDLNAAAPFAEGTTRRRHAEFYVRSNDTWRETVRSAYHKLSGNEEAVRGTVVTDGSKLEDATEIIASCADDMKALWEDQVVRDLLKRKRIRMELSPGFFLNDIDRITQRDYEPSDNDVVRSRLRTVGVQEYKLVMEKYERSAPTTEVAREWMIYDVGGSRTSRAAWYPYFDDANAILFLAPISCFDELLAEDRRVNRLEDSFLLWKGVIQSKLLAKCIIILFLNKYDLLEKKLAAGVKINKYLPSFAERENSATVLAHYLHQKFREQHREYTPDPTRPFYGYVTTAIDTKATASTLASVRDGILRHNLQRADFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4G9</accession>
    <name>A0A4Q9P4G9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_467876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4G9"/>
    <dbReference type="STRING" id="114155.A0A4Q9P4G9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="7">
        <location>
            <begin position="401"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="751"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="751"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="777" mass="88501" checksum="FE7FB348A6CEEB42" modified="2019-07-31" version="1">MPPRRRQQFTQESIDQQLQQIHLLDQASSSENLEQLGPIIKQIHANRQQEAYLRTLQSLIESKDSEIESICGDNYQEFISSVSTLFSIKSYTTNLREKITTLDQSVSQVGKSLVEKKKALLQTKKTAANLDEAIDGLQACLRILDVVNRVGEMVKEGKYWSALRSLEDIESMPPTSLSTTPLFQHLLSSLPSLRGQIKDAVTASMKQWLLDIRNVSAQIGSLALEAMESRTRRWRSRREKDPMLKSARVGSAVETITYEKTEYNVLDNDQLQVDFKPLYECIHIYSALDSLDEIRRSYQADRKAQSDLIIPEPLPLSSLPSITEEIVGYFIIETHVLNTTGSFRSEREVEDLWDALISRLSKAVEDVLKNETDPDTYLKVKEALLGFVMTLESYSYSTGSIHQLILRLFEKYVSILEVKFGRRFESIVAQDDFQPMYVEKDSEKDSVMDTVWLTREQRDQLRKSNAPLNLPWSQGFYLCCQDIRSFVQNFYQFIEGVAQHHRNIDDLLSKSLNTILITYISQSIAKRAQSTANVSQIAQIITNLEHFEISCAELQRSLTNIRSSQRGGTIRVKAASSFIETRTKAIARITEAMSSKLDDFFGLSEYDWTPATREDAPSMYLYELVNWLTTVVDSLALKDTYKEDAYRGAVGYIATCFMEFLTGRDIPKMNENAIANLLLDIDFLDEELKRNGHSHSAAFTELRSMTSVVMSDAVSAYLVASIRQTSYPAVKPKRLAALLDKLARHGFECRDAPSRERGEKRRKEAEAVSRLFPGENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5Y0</accession>
    <name>A0A4Q9P5Y0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_806122</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5Y0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P5Y0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="503" mass="56807" checksum="695EBA089AEBC027" modified="2019-07-31" version="1">MHSSEEPPFAFYGAGPSSIPKRKPDERTRAEQVKRDKPEQLWFSANEASAEERYDDALALLTEAIALAPGNASYYVTRAATHMELRHFAAALRDFEVASTKTTYEPSTINHLRIARCRLILGSPSSALLALRDALSLDASNADALQMRRRVTELEGHMDAYKKAMVRKHWRSARNEYESCLSVYAQQDSDAPEYVQCWGVELLIAEGKWDEATKSVDVLLHNAPNDIEVMTLRALVLFLKAESSAALTQVVTVLKLDPDNQKAKALWNRVKDVARQTESGEKALRQSDYETVINSWTNALLVAGEREEEGRGGILRAVLLLNRAEALCKLGKSSEGLKDVQESLKLHPTYSKAFLCRARIMIGLELFETAVVDFRASLEHGEATLSAEERCDIEAELEDAVRQAEEKESTQQDHYAVLGLTSSCTASEIKKAYRMLSLKHHPDKGGIEEKFKQLSSAYEILSDEEKKQAYDATLHRSYRQSWWWTQYNDDSHDYKTNYNYNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9M0</accession>
    <name>A0A4Q9P9M0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_835318</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145396">
        <property type="protein sequence ID" value="TBU51108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9M0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="488" mass="53242" checksum="ED84284A56BD9385" modified="2019-07-31" version="1">MANRDVSLNSDQNNESSKRPARKSKTKLLQNPTWGSKKPKGNFKSAGQSAEKSTRPHSADLEVVGTPNGSKKKGIGCRSEGKGTQKAKRKRVLSDSESAKSGDEEQAVQGDGKLLPVEQVKVPKKRKMASTGAPTSQSSANFDAPDIDIDGTESSSTEDEPLLPKTPARVKSNKSCISKQKEGANDFNDDGEAAGHDSLGDEDDERPEERDFGERMTDTQVSHERINWTAGPTLKAHAGENNDGEELSGANIPSSQDTPTAMRPDRPRTRKAPPSDNDSQSDSPSDPPRPRKGGARKEKKKQARRLSPLLTACIFTLTIHLHPHPITQKLAQELLTVTRKPLRGQSAASIVPSDSEGDCNWLQRTDITDALTPSSSNKWTVNLKPMGPELHAIMKLSFTLCQMHFVFRDLNDPPLTSSEQVPRIVTGFDNAGANDFALQALVKAATDKGYDGENDIVDRLLYGSPNLYVDPLVGYVSISYWYLNMIPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAM2</accession>
    <name>A0A4Q9PAM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_834204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145313">
        <property type="protein sequence ID" value="TBU51508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAM2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16630" checksum="1549A2EF17EBAD21" modified="2019-07-31" version="1">MAEIARQHHDAVQSDESVNSDQIVREENILKVLDSLETKLSSDEADMVGELVSPSEVLEAMRAAENGTAPGLDGIQHEVWKTLHERFIEDEHAERPSFNIVNVLHAAYIDIQTFGVSKGTGFSDGWMAPLYKKGVAATRRVDSGRRSATTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAV2</accession>
    <name>A0A4Q9PAV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145303">
        <property type="protein sequence ID" value="TBU51598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAV2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10050" checksum="9924694B72535159" modified="2019-07-31" version="1">MSPFSLLVASPVTPCLWDVSGYHLLAVDFANRTTCGSKLRRSKSLSEWGGSGYTERTDLVALPPSRPTTELFEGVRGLRVLMSIIWIVHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB82</accession>
    <name>A0A4Q9PB82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_273837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145274">
        <property type="protein sequence ID" value="TBU51960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB82"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17509" checksum="F154305E0F681544" modified="2019-07-31" version="1">MPCVPRSSVMWIVLVASLLSFVGIYCVNTMIHNTTSLTSTAPGSLTSNLSKAGFYVVHVTPEFLAAAVLLSLNAHCVFATGMWGDWQISDPRLQNNTPGNMSSTSRLNSLLQFLWCSPLVGFLLRTCGAMRNRRVAPVSYFWYSATVCFVVCTRNKALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB91</accession>
    <name>A0A4Q9PB91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_833613</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145288">
        <property type="protein sequence ID" value="TBU51758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB91"/>
    <dbReference type="STRING" id="114155.A0A4Q9PB91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU51758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="548" mass="61830" checksum="1CD3CE46E22E47C9" modified="2019-07-31" version="1">MSSQVLQAAVTCVVCWVLWKYFRQFFVRSPLDNIPGPPSGSWPYGNLKQILNKNGWDFIQHLTDSYPGIVKLHGPFGHRMLYVFDPIALHHIVVKDQNIHEEGAWYIKFNRLRFGPGLLATLGDHHRKQRKMLNPVFSPNHMRRIIPIFDAVCRKLQKAIGDRIGGHDEPVEVDMLTWMSRTALELIGQAGLGYSFDPLVSDSSDEFAAVIKSFGPALVKMNHLRRILPYLPEFGTAAFRAKLVELFPHDGVHEVKRFIDTMHRRSVEIYRGKLRALELGDEAAARQVGEGRDIMSILIRANIAVADEDKLPEEEVIAQISTFIFAGMDTTSNALAMTLMLLGDHLSVQQKLRDEILSTFDDQNQFDYDKLVSLPYLDAVCRETLRLYSPVTQIFRESRRDVVLPLSEPIRGVDGKMIQEILVPKDTTIAVGILSANRNKAIWGADAMEWKPERWLSPLPESVAQAKIPGVYANLMTFSGGSRACIGFKFSQLEMKVVLCLLLAKFTFAPSGKEIKWNLSNIRFPTVGDDPKPSMPMKVGLYEEAVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB95</accession>
    <name>A0A4Q9PB95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_910357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145274">
        <property type="protein sequence ID" value="TBU51974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB95"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12117" checksum="6385C2DFF3FD389D" modified="2019-07-31" version="1">MAEDKHAGVHAASAKLQNGWPRLAGSALALEIGVDCIRPQSEGNQGKLSRDHAYLNAEVSRLEYGMITTYMRFSVKVFDLLLPSISMSPVFNHAVVLYYLHVVPYRTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBB7</accession>
    <name>A0A4Q9PBB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_915096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBB7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBB7"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="21262" checksum="17CB0E81221759A0" modified="2019-07-31" version="1">MRDVLKTEELDIPEGVTVDIKSRLITVKGPRGTLTKNVRHIDMDIRLQKGKTNKVALAVWQGGRKHVACLRTIRSLIVNMITGVTKGFRYKMRAVYAHFPINCIVQDGGRALEIRNFLGEKIVRNVAMLDGVTVSESKSQKDELILEGIDVQNVSQSAASIQGLCRVRNKDIRKFLDGIYVSEKGTVEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBK8</accession>
    <name>A0A4Q9PBK8_9APHY</name>
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        </submittedName>
    </protein>
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    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52134.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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    <name>A0A4Q9PCK3_9APHY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="TBU52544.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
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    <name>A0A4Q9PCT0_9APHY</name>
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    </gene>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="161"/>
        </location>
    </feature>
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        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17859" checksum="D014AE74212C0508" modified="2019-07-31" version="1">MLGLSSMAFPVSCFPSRSLNFAQRANITASSIHLQVRAVSSSPYGRTHVWKRRQKKLPNPMVPVFPQRLVRVDGSTIVHWTTSPRSVIRLTRDTTNNPLWNAARFVGMDEEEDEVTGRMGRFSRRFADLGGQKSDLDWLDEASGTEGYSSSTGGTAKGKAK</sequence>
</entry>
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    <name>A0A4Q9PE16_9APHY</name>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51302.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
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    </evidence>
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</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="TBU52395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="24"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16390" checksum="C0D08E00C4E8F3B4" modified="2019-07-31" version="1" fragment="single">IGKPDNLSDLCILAQSLDHRYWERKAERNRETSGPSKSSSKSGSRTSQSEPRSSSNSQLTPRAPQKSSDGKSSASGSTPKSNSKPKSTDKSAPKPYADKLRKDGKLTPEERQHRLAGDLCLFCGGAGHSTNTCPKKSTPLAKGRAAQAEPTPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEG3</accession>
    <name>A0A4Q9PEG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_778995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145335">
        <property type="protein sequence ID" value="TBU51361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEG3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5937" checksum="9BC4E6EC59B0FA88" modified="2019-07-31" version="1" fragment="single">PLAYVEWFTAFHVVDPITGMNVVAPSTRSHRRYATVIPVTDIVRSCHLMLNPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF36</accession>
    <name>A0A4Q9PF36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_910577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145305">
        <property type="protein sequence ID" value="TBU51581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF36"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020714404" evidence="1">
        <location>
            <begin position="22"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="230" mass="25601" checksum="810DCBE43219FCCD" modified="2019-07-31" version="1">MPLRTTMTALVSLCLKVPVSSGCFEWTRAMLEDISGEYGKQRRPLPFCFGNLNMLPLPVLKACRFRCNPSSTLPTPLPSASPTIAKSWAHPSNQASGHGGSKYGGAFGADAVGTARGEITAIAHEPLGWRRCSSLPAEDVDLARLLATLRRRWQNSWQNILANTPAVVRRLRQVDCTDRNYLHYLTLPWPIPELSYVYREDRTLATKQAAFRAPWLRPGRNLDDLVTLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGJ4</accession>
    <name>A0A4Q9PGJ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_139176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGJ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGJ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007255">
        <property type="entry name" value="COG8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21311:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04124">
        <property type="entry name" value="Dor1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU53575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="580" mass="63085" checksum="35811A89592CB59C" modified="2019-07-31" version="1">MTDNVQDGELQTLPDILASSSQETLSASLSSAEAAPYIAHLTSLSLPELEAEPTELASSSAQLTNALTTLCYTSYPTFLSLHSTTSTLSSSLDSLSSSLSSLLSTLPNLESSARAFAQDSRTLLSARRKAALVLEHHDRLHDVLSIPMLLETSVRNHNYADALLLAQHAYTLAARFPSNPLVQSVKADCDARVHSMLAQLLRVLHEQAKLPALFRAIGFLRKMDVLSERELALAFLSGRSSYLETTLRAVEVEKKGMDGESSVEWERESQARYLKRYVDAWREGVHDVVTQYTTIFLDPPKGAEPAPPELHILLTTFTTLHVRRLLDLLRETLPLVADPSLLTSLLTQLTYCATSFARVGLDFRSALAPLFTIAVRKGVTREFEEATDAWSRAIDPEDTSKARSRTGASARRKPSQFLLAPAAASTPPIPTDAQLSGLRSAAANTPPAILTSYPPLALYTNALLTALNGLRLLAPASLLSELLVALERSLAHGAIVLLVLARSASDERTNGTSNAEDAKREEDAVRAAGVVYVKVFVPFIRRALLEGVYGVKMDEEGAAVGEDLTGVLKEWDDWLESMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGR1</accession>
    <name>A0A4Q9PGR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_941657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145288">
        <property type="protein sequence ID" value="TBU51756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGR1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGR1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU51756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="244" mass="26704" checksum="130AFD31066CA11B" modified="2019-07-31" version="1">MAPRSRKSGPSPSPAPPTSDTDAAPPLSPKDDSSVAHRSSIDALLVPVAGEEREEVKVNNASVADMKHACDDALKRFLSRPDLFKQIHTHTDVRLALGWLSVLIAGGTGLYGWRVPFEQSKPAVWAGVILYVILTITQTLYAYFIEGDTVFVGRRKTFDKRIVTERITITAKTTPSTPSSPPGYALGLAYVRSASGGKTLLGKGRASEERKFTEFFDERGVLDQERFERWVGQVVGRVMDGKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIJ0</accession>
    <name>A0A4Q9PIJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_798239</name>
        <name evidence="3" type="ORF">BD311DRAFT_630099</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143616">
        <property type="protein sequence ID" value="TBU21387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145209">
        <property type="protein sequence ID" value="TBU53606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIJ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIJ0"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8115" checksum="14B585B629DD42AB" modified="2019-07-31" version="1" fragment="single">AQATFKSIKPTVPLFDCVLIQRSMPETKTALDIFLPSSTDHNPLPEATVITVGPGAPNKDGNVLPAAVNALPKPVRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ61</accession>
    <name>A0A4Q9PJ61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_936555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17979" checksum="A5B5ADB27709C316" modified="2019-07-31" version="1">MIVGRFHESTKRFPSSSVLVAFHSTAPCRFHGLETSARKDNRRRHGNQYEMSSERELIRRPQGRTGRKRTARTGPSVVAALLAQNSFGECVPDRATSMKCLIPFALQTFGLTSSIPLVAAIDTLETVLVPPHSSITVRNPYAFSYPTYRSISHIIVRGIAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJP0</accession>
    <name>A0A4Q9PJP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_828353</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145192">
        <property type="protein sequence ID" value="TBU54304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJP0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="23188" checksum="D48DD7CE1F399338" modified="2019-07-31" version="1" fragment="single">MVVHRWGVAGRWGRRPLPVAAHRPWPLSRRRRRLQRSACSTPSLCLPWPKTCLVPPPLPIPHHPSHLSLLPEVSRSSTSLQSSYPSLLTTFVSLQPSTSHRTGTRYKEKFQALREKYDQVTTAHTEYERALARADDKLKRLQEECNLLLDAVDIAVPAQPSLVHYLKSDPIAPPYYSYTVPVPPAGAEGPPPPRDIPFGGPPAPPQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJY1</accession>
    <name>A0A4Q9PJY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951454</name>
        <name evidence="1" type="ORF">BD311DRAFT_779623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143445">
        <property type="protein sequence ID" value="TBU26501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145189">
        <property type="protein sequence ID" value="TBU54404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJY1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU26501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8706" checksum="F8575A6D682F63A7" modified="2019-07-31" version="1">MRRDLRVIQAVRSHEVTLYPCSSVDDASIAALYSCDHPTLYASTSSRLAPRPVRRRNLCFHTNIPWIERVAQALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK25</accession>
    <name>A0A4Q9PK25_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_951388</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK25"/>
    <dbReference type="STRING" id="114155.A0A4Q9PK25"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF10">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020777778" description="tripeptidyl-peptidase II" evidence="12">
        <location>
            <begin position="20"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="13">
        <location>
            <begin position="214"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU54490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="575" mass="60556" checksum="D664BD6956C6D155" modified="2019-07-31" version="1">MVVPTSLLALSFFSSFAVATSLPFKYSQNLLVHESRDFLPTGVSFIGPAASHTPLKLRIALSQTNPDAIVTALLNVSDPASADYGNHLSKSEVEALVAPSSASVSAVNAWLQEHCLSATAISPAGDWLQLEVNVSKANSLLAADFSTFSLPSSDAKAVRTLSYSIPAALKGHIDLIHPTTAFPEAIKTIGLSKRAIHEPVLPRAAVASSKCGSGTTPACVQSLYNIPTTPATNSSNKLAVTGRFGNNAHYNWLQTFLKKYRPDMKSTTNFTVVGVDDGNNDQDAPSVSEGELDIQYTVGLATNVPVQYVMVGVNWTDDGLNGYLDEINYLLSLEHPPQVLSTSYGYAETSMSYALTDKLCKAYAQLGARGVSVLFASGDNGVGCQDSNTTLFQPTFPSNCPYVTSVGGTAGSGPETAWAGSSGGFSNYYAAPSYQASAVDGYLTAHTSSANYNATVGKYNPVGRGFPDVAAKADDYRVQETSIASIYGTSASTPVFASIVALINDRLSVKGKPPLGFLNPWLYSTGKSAFTDITKGNNSIECNGETAGFEAVEGWDPVTGLGTPDFNKLLKTVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK93</accession>
    <name>A0A4Q9PK93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">CAS/CSE protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_1041713</name>
        <name evidence="9" type="ORF">BD311DRAFT_785753</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK93"/>
    <dbReference type="STRING" id="114155.A0A4Q9PK93"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU32703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU54547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="989" mass="109490" checksum="078BF6A6C97BC5EC" modified="2019-07-31" version="1">MAELPSLLLASLQPDSRKQAEQSLQSLSVQPGFLPHLLTLVLQSTQDRAVRLAGSVYLKNVVKSRWEDDEPPIADADRAGLREALVPAMIQLSNASDKAIRAQIAETISLVAKSDFPERWPDLVDKLVVSLSESNYEVNVGVLETAHSIFRPWRAEARSDALFTEINYVLSRFTTPFLSLFLHTTTLLFAQPPPPNLAQVAQATVFLVEIYYDLTCQDLPPGIEDSHAQFFGAQDGLFLRLLLWDPPQLRGDPDDTTPSLPSQIKTRILEIVELFVKLYPETLQTSGTVEAFVRAIWDLVGGGKRPGVADDGLVSQSLRFIAAAIRIGYYKDLFGSKETISGLVQGVVVPNVALREHELEQFEDDPLEYIRLDLALPSMGGIGLSHDAVTRRQAAADVLRALVSSGLEAETTEVTGAWIGQGLAEYNADRAQNWRAKDTAIYLLTAVATRGSTTQHGVTSTNALIDVVQFFSDHVFGDLQAEEGSIHPILQVDAIRFLYTFRNQLVKPQLLSVLPSLVRHLSSDNYVCYTYAAISIERILFIRQGTQLMFTQADVQDVAPGLLNALLSKVEKAPSAEKMAENDYLMKCAMRVIVTARSTFANGYEQILQRLVAILGVISKNPSNPNFDQYIFESISALMRFVVQANPSTLPRFEQALFGPFTIIIQQDIDQYIPYVFQILAQMLDLHTGEVPAEYRSLLPFLLTPASWQQKGSIPGLVKLLEAFLSHDAKSMVAAGQLTQVLGVIQQRLIPSKINDGWGFELLEAVVRYTPWDALKQYFRGLIVTLLTRMQTSKTDKYVYHFVYFLGFCLAINVDGLTPDYIIGEVDAIQPGLWSQLLANFIIPQAPKSPPKERKVVIVGLTRLLTQSALMLQDARVQAWPPTFQALAKLFQTEQLLTKKEELDPDAGLTQIDYEEQTAGYQAAYSRLAAAEAAPADPVAHVKDLKAFVGQELAQASARDRRVKAWVAQTDASVTEPFVQALAASGFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKI2</accession>
    <name>A0A4Q9PKI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Terpenoid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1041670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145184">
        <property type="protein sequence ID" value="TBU54657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKI2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="321" mass="36545" checksum="0D3D119216E7A980" modified="2019-07-31" version="1">MTYAAPAGKNITSSVAEPHHDVRDILSDFLKRGMANKHARHSILRHKDDHLYDDIIKEVADIFAAAGDDKIFVERFSRTGCDLAQITYGHTSTEHQHYIALYTVCLLYADDLGIRHLDALSQFARRFSTGEKQLNPVLDKLTELMRQAYDLWPQVGADAIVSGTLEAVSAMYIECTSGDMKITPQATLWPNYFRNRSGICPPYAHFNFMKNWRSAPDSYLQLLPYLEFYIIAANDVLSFYKEQLAGETKNYIHIRATTDQMTPVDMLRQVADEVLASGERVELLIGDDAQLMRIWRSFEHGVLEFHVKTQRYQLAGLTFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLK4</accession>
    <name>A0A4Q9PLK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_712006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLK4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLK4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="360" mass="38339" checksum="4C2BE97648205C3D" modified="2019-07-31" version="1">MPLVFGRPVIPVLLPPALACNYPHHGTLWTPVPAAKGLFLCRPAVSVLVDASSRGRLPNAMPGTIRLHGLTKLSTLHPKSRLGEVGERARVVRTQCLAVFSLFLLGTHMAPFVQGRALPAKFLPDASVTLPQFVPTGVYNAGRGRRRAVSDSRSDVASPSTSDPQTSSPARSDSTAAGTSSGTSASTSDSVRATTDSVTSTDSETSTASDAATQSSSQTVMTSVTPANPGGSFGTSSTSATSSTSTSNTSSTSGTSTLATTSTTSLSSSTSATTSRQTSTVATNHSSSSTLHITFHHRYHYVTRVFHDVNQLYIFFILRDCIIFKDYFIPDYFIFDYIIADFFISHHQFSVHINFELITL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLX7</accession>
    <name>A0A4Q9PLX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_707503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLX7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="17576" checksum="FE48CD5CFA275E1A" modified="2019-07-31" version="1">MFIATDSWGFESGYRITYVRERKFYARTVRTGINIDKGRKHARMSSMIGRIMLYQYIRQRGATRDVYDMCNGEESERWRASMIVERDQVAKSDGIIVTTWVANNNTQGADKPGKQTRDFLQRKPTDPKRASFVAQSGRGMQGEPRRQTRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM64</accession>
    <name>A0A4Q9PM64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CMGC/CLK protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_826157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM64"/>
    <dbReference type="STRING" id="114155.A0A4Q9PM64"/>
    <dbReference type="OMA" id="RHHIQSF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="502" mass="56489" checksum="1A784D50D73E9F78" modified="2019-07-31" version="1">MPTPPVTARKRKRQQYTVTYSEVQEVDSSGKVREVIVIDDTPPPTTVSPATTHTAMYSASYQPPVYNAPIRTRARAAAEAQALSASTSSGLTVAPAPKKRKRDPADDIGIIPKKTITNGGIANGIAVTKSFATGSGAIADDASKPEGPCDDKEGHYIIVPDDMIHSRYRTVRLLGQGTFGKVVEALDTETNRRVAIKIIRAIPKYRDASKIEVRVLQKLKERDPLNRHKCIHLLTWFDHRNHICLVSELLGMCVYDFLKENDFAPFPRQHIQSFARQLLGSVAFLHELHLIHTDLKPENILLVNNDYQIVQVPTSSKRGAPTRSKRILHSTDIRLIDFGSATFEDEYHSSVVSTRHYRAPEIILGLGWSYPCDVFSLGCILVEFYTGVALFQTHDNLEHLAMMEQVMGKMPERFARSGARAKPEYFKEGCKLDWPKPKATRQSKKEVRACRSLQEIIPATDPINRHFLDLVKKLLTFDPAQRITVKEALNHPYFTLQIPNEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMM9</accession>
    <name>A0A4Q9PMM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="16">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_969208</name>
        <name evidence="19" type="ORF">BD311DRAFT_730492</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
            <strain evidence="19">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 16">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="16"/>
    <dbReference type="EMBL" id="ML143491">
        <property type="protein sequence ID" value="TBU23931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMM9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMM9"/>
    <dbReference type="OMA" id="SAWANFY"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000119">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 16" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="18">
        <location>
            <begin position="7"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00053724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU23931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU55503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="277" mass="30826" checksum="280CDBCCB1F07E81" modified="2019-07-31" version="1">MSGIHYSVVVPAYRENGNLRPLVTRIFGALSQAGSPVSPHEVEVIVVDDNSRDGSVETVDDLRREGYNVRIIVRTTERGLSSAVVRGFREAQGDNMLCMDADLQHPPEYVPAMLASMSPTKQFALGTRYAKGVAIDEGWPLYRRVISNGARLLALPLTSASDPMSGFFGIRKETFLKARNLNSDGFKIALDLLVKCNIPAKAIAEVPFSFGVRAEGESKLTGKVMIRYLEQLAELYWYRHSGLVIFLAIFLFVLFVFFAQTLLSWYGGFDDQSQGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMV7</accession>
    <name>A0A4Q9PMV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_979518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMV7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMV7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="373" mass="41132" checksum="D5C0C9CBADEF1702" modified="2019-07-31" version="1">MADILAGLLSQFWELRVSVYANVASLALLVYDWQLTFGDEVDIMWMSKAKFSKLLFLWIRYFGIGTHTFIVGAMYLLPDPSPATWFELLHDPSCRVATTFQTAGPNIMWWSVEFVFALRVWILYERSRKLLLFLAMMYTASIGASAVLLVKALLHVDLITVPGGVISGCFSSVPIYIYSAFVIGIITTSMLCVLTLYQTIRFRDGLTRSPLITLFLRDGLVYYFVYERVSVVFLLNLFMFRFGAATFKSLFSGFLEAIPCMFGARVLINILSLVQKQSGVSDTAPPYSEPKFRHTSTAGFDSGDSVTSSGTDAGTSTSGTVTVDSGREAGTHPSARSSSSGMTLSRGALSACAMGIEEVLRTYSDDIEKGYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN54</accession>
    <name>A0A4Q9PN54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial tricarboxylate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_933085</name>
        <name evidence="11" type="ORF">BD311DRAFT_765719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143471">
        <property type="protein sequence ID" value="TBU24876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN54"/>
    <dbReference type="STRING" id="114155.A0A4Q9PN54"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000007">
        <property type="entry name" value="Mitochondrial tricarboxylate transport protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="5"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="99"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="196"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU24876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU55690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="288" mass="31327" checksum="E5735EDCB613AE9B" modified="2019-07-31" version="1">MSKKEKPLHSLIAGTTAGAVEAFITYPTEFVKTRSQFSGKRQSPIAIIRDTLKTKGVIGLYSGCMALVIGNAVKAGVRFVSYDHFKHALADAEGKVSPPRSLLAGLGAGMMEAIFAVTPSETIKTKLIDDAKSPNPRFRGLIHGTAVIVREEGLRGVYRGLFPVMMRQGANSAVRFTTYTTLKQMVQSQGRPGQSISSATTFGIGAIAGLVTVYTTMPLDVIKTRMQSLEARQAYRNSFHCAYRIFTEEGILRFWTGTTPRLARLVLSGGIVFTVYENIIKLIGGRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNQ4</accession>
    <name>A0A4Q9PNQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_825007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNQ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6503" checksum="094B505F3A111367" modified="2019-07-31" version="1" fragment="single">AAGIALPLPIPITSGLSAVTSGSVNPSSIVLKVFVPPPGLVPLHPLPPVRYSYSRVIWYLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQV7</accession>
    <name>A0A4Q9PQV7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1040359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQV7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQV7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="968"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="558"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="629"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="794"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1233" mass="133960" checksum="57CE057AABB0623E" modified="2019-07-31" version="1">MASSSTQTTPAQHHPLSQDEVPSRGRRSRGKPSEDSPRPQTDYFALKAKLDSASKEHTRYTNANWDGSVRGYGKGTRSVKPPPLIVVESSSEDISQPPKYELLGGPSAERDGSGPFSPSTTAKILSTKWHAFADEEIRSTVTVYATTPSPNELSEHPCYAIMRVLSSAVHNLTRARHELEESRRVLLEKEAARKERAKQLLQELSSSEKEIGNRVFQSLFPDDDETSHHVHRMQRQQSVLSLAESLTEAIEDEVPISRSVPEGDVTPMASVLVVPPKPQISTTVVTAQAVPASPVASQSVAETLPAVQVEHADTTDTPGTTDNDESRAASADLSKTERPSLGDWMGTWWIKPKSKTRAPQLPFPADDASDPHKESPRADSQSLFGDDLPPAPSTPQTPGKESAAPKRKPSRSVFGTLGFSILNPASSSTNAMMGKKRRNMSVTDVAGAELSPEPQDVTPSVKSAHVSPSSSPLLSPVAVNPDLSMVTSSTNASPSPSLMAPDEKPPQGTSLRAIIQATRVMTSDASSILIDHGRETSPLIAQLALELVRNAREAGLDFRERPKEKRERKAGGAERRASPAADADATPVPSRILTTAQVGRRTPKSRKPSVNLPSFASPLFGSFAIQQQKKPAIPSDSAQQNPSNDASQGNPSTAAPQPMSKAKAGSVPLESIIPVNAKPPTQYLSRQYTPLTSRDFHFSIPLPDNESSIAAQVDERSHEGLTDRFGFIYDIARYDALLLIRAKECKNTAPACLTGIKVADRTEDNTWPEDEEDVTANTIEIVKDGCDCNGEGDDGADAISVNSTSTRPTVRSVPAGDSTRSRGTSPASSRRVKRTSTLLSGASTATIKSTSSVLSVDSETPRHICGNTIRRLLSQLTDIHDQRQAAQRKEWDLFLKNRSRAMTSKAMSAGSRSASAGVVGGAAQLLGLGTADEAEELEHNEGLIGFAQFGLSSSKDEKKEFDRLVRNGIPLAYRSKVWLECSGALEMREPGVFADLLAECDTTSSVVREIDKDVCRTMPLNIFFGRTGAGVEKLRRVLMVYSKRNPAVGYCQGMNLVTSTLLLVHADQEEAFWVLAAIIERILPDDFFSPSLLSSRACPLVLLDYVQDLMPKLSAHLAELGVDLGAICFSWFLSLFTDCLPVETLFRVWDVFMVEGIDVLFRIAFAILRTNEHELLHCTSIPAVYVALESLPNRMWEADRLLQAEADLRSTIVHADIVRRRNAHIAQLREVMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQV8</accession>
    <name>A0A4Q9PQV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930929</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQV8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="35516" checksum="1CAC82FC2A9032D8" modified="2019-07-31" version="1">MQPVYWYYHDPRAVPLTNTPSWSPARSPPEAGYGPSAMVPWPWGAAGYCPHYPPNFLSNGVRPSVPQQPIIHGQPAPVIDHVPIHEDSGPRYPLSVLSQSPNLHPVVERLLLAIPRPRASSRWSPQDDPFRPFAEAGVDLSAPELRAALDEPAVPEWQTVFGRDAPRRHVFPSIRVVFSPLGEYGALVVSIRVTRGHYYVAGYVSGVSCRPVENEPATVKDFLYGLWRGLTEDLGLESDEGRGIPSGWMSKAVRSANRQSPEGGPAASSSSLGDKLRVRRIDFLSGVRFSSVETYGPRIATQAAGRTPILEVVVRRAESSRGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS79</accession>
    <name>A0A4Q9PS79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD310DRAFT_929617</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PS79"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000087">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1123"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1149"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1202"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1243"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1268"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1307"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="112"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="343"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1088"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1362"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1397"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1425"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1443"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1499"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="1510"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1526"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1361"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU57250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1623" mass="181514" checksum="70AD9E1C09F3FCB6" modified="2019-07-31" version="1">MSLFRRNAHPNDELDTDDEINDGIDPELRLRTVRTAASTIAESIRQEQRAERRKSTRRKGSRFFRRGTEKRRQETADSDSPATQPNIHGRRRNVYVNVPLPPDEKDNHGEPIIRYARNKVRTSKYTIVTFIPRNLYEQFRRVANLYFLALVVVQVFSIFGAPSPQTSALPLIFILTVTAIKDGIEDYRRALLDDEVNNSAATKLGNWRNVNQPTDPRNWFEKMLGLNPPGKVTRGVRRLREKEAGEGKQIVLSKAGDGRASVSTLNVNDGNSEMGYYGAGRKLEDIQSVDSHSYPPPQEARGTVMSWGAGSASGSLTAYQQSIRERPSVGVIDYNRRTSGLARWERTLWKKLEVGDIVLLRENEQVPADIVVLSTSDPDNMCYLETKNLDGETNLKPRKSVRATSSITSEEDIERVSFVLDSEPPHANLYLYHGVLRYTDPSSGEQKQESVTINELLLRGCTIRNTAWIIGLVVFTGADSKIMLNGGDTPSKRSKIEKETNFNVIVNFVLLMLMCIASGILNGYFDSKGDTSAKFFEVDSEPSSSYVLNAVVTFVSCLIAFQNIVPISLYISIEIVKTIQAFFISQDVDMYYKPFDAACTPKTWNISDDLGQIEYIFSDKTGTLTQNVMEFQKCSVNGIAYGEGVTEAQRGAAKREGKVDAMDPQEEDIHLQVLKQRMIEKMSQTFKNRYAQPDHLTLISPRLADDLADRSSPQRQHLIEFFRALAVCHSVLSERSDSAHPFHLEYKAESPDEAALVAAARDVGFPFVHKAKDAIDIEVMGQPERYIPLQLLEFNSTRKRMSVIVRNPQGQIVLYCKGADSVIYQRLAADHDPELKAATARDMEAFANGGLRTLCIASRVMSEQEYMDWVRVYEAATNSITDRDEEIDKANELVEHSLRILGATALEDKLQEGVPEAIETLHQAGIKLWILTGDKVQTAIEIGFSCNLLKSDMEIMILSAETSAAARLQIEGGLNKIASVLGPPSLSLNRRGFVPGAQAAFAVVIDGDTLRHALSPELKQLFLTLSTQCETVVCCRVSPAQKAMVVNLVKEGRNAMTLSIGDGANDVAMIQEANIGCGLLGHEGSQAAMSADYAFGQFRFLTKLLLVHGRWSYQRVADMHANFFYKNVIWTFAMFWFMIFNSFDATYLYQYTFILLYNLVFTSLPVIALGAFDQDLNAKAALAFPQLYIRGIRGLEYTRLKFWMYMLDGLYQSAVVFFIPYFTWTLGLAISWNGKTIESLADFGTTVSVAAIICANTYVGMNTHYWTVITWVIVVGSSVVMLAWIAIYSLFESIDFIDEVVILFGELTFWTAVLVSVVIALGPRFLVKFFKSTYWPLDKDIVREMWVLGDLKDRLGIQHRRNRKKQAKLEQTPMFHQPHIRSESEISQPDDEYGTPLTYTPPTSRTPMSDGSPRPTAPLMAGESPRPERIAPDLHESKRSPIASPTPSARAQYNASPSLQRLSYYSASNIPPPSPLPESNRYHYTRSQYGGTEPPMSAVSHSSVSYNQPPTSPTYLSPPPSASLQVPGQRSPRATSHAEQYEMRVRSPPQEQWAAHPGDPPPSAYAIHTPMATEDSFVTAHDDPGVDDAYAYDAYTPTGVEPSHQQEESWRSSTYSYSGPHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSB7</accession>
    <name>A0A4Q9PSB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_772043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5415" checksum="32DF9CB545B95871" modified="2019-07-31" version="1" fragment="single">MCYHQVQPTPSNPPWPSLLCVATTELVTAADIIISLLPVPFHPSVAELCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTR7</accession>
    <name>A0A4Q9PTR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_513833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="128"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="323" mass="37245" checksum="A3125A060CF1EF2B" modified="2019-07-31" version="1">MVEVVLPRWEDVRRRKKIQAERARDTLAGRSRLPELSDSASAPRHDSGLIEIEPEEDVKPLVALEDYDPDEVVEILHNAVQKLRHPDAKVKKELLFNDEFLLDALTWEGINHKYPIPLPKEIAECRLRREYISHLYGGNPLATTPEHGKDMLAWHGLNDWLFLTLDFNPHAPTKPGHSGLFFTSYGAPSWPGIQRTFVRVVSGRWVYMGQYTMEPGVSLSAEAWKQQKTSVRKTWVKSILSKRWGEDNCIAIWIRKRRGSDCTITAEDKEEARPMLKHIRANLTEEDISGAFDRGEEEIGTYRMRCVGYDAEFIDTLVRNKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUE8</accession>
    <name>A0A4Q9PUE8_9APHY</name>
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        <name type="scientific">Dichomitus squalens</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="20406" checksum="AEDE46948B3918C2" modified="2019-07-31" version="1">MNAAHPTITIDLVLDRLQTKEVLRAMLHAILFHRLFGTIRSRTFEVLDVTMPGVDDEEIKQLVEDKVDAFWKGVEGDANKRGQILVTFSEKRPRKSWFLIGEEEIPWEQWVINAEIRQPSERERQKFNSDLASTLTKSLQTMLTHASSEGGRSAVPLITNAQSISPFPIKIAVKVGGVEVA</sequence>
</entry>
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    <accession>A0A4Q9PUH9</accession>
    <name>A0A4Q9PUH9_9APHY</name>
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    <organism evidence="1 2">
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU58222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10638" checksum="14F0C65C74D4206E" modified="2019-07-31" version="1">MTVSSWPVFVMSVAVLLSPFSERYHRVSTSSIPAHDTDSTRGSQRYLSAPVLQVRAGCPETGTTEHRSPSAALRKMVRKRHVAGYSGHYSLHYAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUW9</accession>
    <name>A0A4Q9PUW9_9APHY</name>
    <protein>
        <submittedName>
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        </submittedName>
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        <name evidence="2" type="ORF">BD310DRAFT_879182</name>
    </gene>
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        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="297" mass="32410" checksum="39FFDF709F905B7E" modified="2019-07-31" version="1">MSSDSAASTPPTLDDLDGIARVYPHGPNQFHIVRPQIEQRASLVKIWGIKPGEKVLEIGCGQGDCTVVLATAVGDEGSVTAIDPASLDYGSPYTLGQAQAHLKASPVGNRITFVQSDPVTFVQSTSERYTTAVLAQCSWYFSSPRVWSDILAVLLERVDRVCISEYSLTASDPRAAAHVLATFAQAALEVHKNESSSNCRTVFSPERLKDAAIVAGLKLQQETLIVPPEGMLDGRWEVGWVLSKDFEKEIDENVKDEREKAVVIAARDSVRAALELLKAKDEKVHTMDVWVATFTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV73</accession>
    <name>A0A4Q9PV73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="2 3">
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV73"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20537" checksum="0389FEFE06BCA95F" modified="2019-07-31" version="1">MAAIELTPATCNRLQNPDDYPILVSRPIVRVDETEELVDRSICGFTARYRLKIVDGDGVELSVVVPDNAKLGEGSAPPGSSLQAGSILQIDQMLRLPNGREHIILIHSGEIVTEDHELIITDLEKVFRQALHETTFKELLVQKGVSPEMVDNFFALLLQIEEVTREAAASRSPSVGPVGAMSPTQPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXY7</accession>
    <name>A0A4Q9PXY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_976494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="278"/>
        </location>
    </feature>
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        <location>
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            <dbReference type="EMBL" id="TBU59622.1"/>
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            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1560" mass="166986" checksum="29AD1058D1B62548" modified="2019-07-31" version="1">MATPFSTPRYPGAPNPTPRSTGKPLRPPIHNPYDKFTQPQFDAWINDITGALKRALGRDDGQPVPLHAADRTAAEDDAEGVDDSFAEVRARRLAKGKQRARDEDLVDNGAPEEHYGDESGWGETYSGQDYSSEDEEGEEESEEDEEEEAPDKPDAEVIELLSDDEDASGEERDGEEEDGETVAGPAPAYDEEEDEGGFDEGIVEDEVAADVDEIVEEEEDAAEEDLEDEEDAYKAQCDEDEDDAHENIHSSPAHEVTEVLDSDEEEAESEPFAQGPVMPARFLRKPDVLTGVHVELDEDQLGEAAEEEQNEEEAEPLPPRTAEREEIDIQDPWQGPSIYAEDFYSNGDMPSDAIEHGGNPHLLPTEEEPNELVADIALTPEIRDPWEGPRTYAEDLYAGGDVLPNPADGVTPSHLTPRDDGEVYIPGISSVRPSAPRSPGQQQDVVDLDAEQCAPSPQVALVTERVQDETEPESTAQDAQEPVDETPRSPSPPSLNKHVNWNWPPAFPGRVASGAGHLTEVDDGIVEISDDEDEDDMAPPDASQAEPNVREAISAEQIPFGSASDGPGSPSMPFSLGFEELYDMDAGAASYSAFEPVASAADFGDLPPSREERHEGDTLGEEAPPGSLNSTTGVTGTEEHVLASEERPASAPGQPFVEEVEDMEGSLPKRSATEELDVVSLPGDDIDVSTRDYLIEEVSTEGRRTEEPEAAVDAADDAAAAAPTLSLNTEGATVGGEYPAPVSADPTVPDPTSVSHTPASPVDSIASSSYDKELVDSKPVYAALLPVIRKGTSAHSASGLFTPMTDGPSGSVTPEHLESGLPHAEAQIAEEHAEAPAEPDVVPSVVEGPETPADEEPSVPGLEGSAAQESVSQGMCTDEGDDSSALIFEPQEAVTAAPAHEDRRTSPAFDAGADADADADAEGELDLEYDPSEGAEESSVAVAEEIIPAAPKTEEDDPFVVKEDAEVPLAEDAERDDKASLPTSVYNENAVKEAAVRQAAEKGAPDASNTTEADQRDEGRPLKRKRKSPPAGPVRITRSKTSVSGLGRSQLVALEISPKSRKGKGKGKQRASRETDDEEDAASVAQSLISEEGSVASSIAAQNLLHEDGSRESSRASSVVSNGLSMYSEASPTVGRTLPNNGNRLVSLPFIHDNGVLRHNHGGRAPVPVLPPPPPKRQLSLPPAPSSRDSVASSRNGVASSRDSVASSREGSAKPSPPATQPPISRPSFTPSTSTHSPATRSNCRYHTISLPREEDDERHVFFAVPGCSLSNAELMEEENIRDHGLTRTDELPSKITPIEDLKISPELMATLRQLTGVDLFREQEVIYLPRPGDNIVPKKRRLRTKLIQRESISARTLPSKELYSAKQTTHKAPLSQMSASTSGGSASVAAKLSERGSASTSGGSFSGSDLSDLEEEDERPTKRSKASPPDPDPDAGEVAQPGVEGSELMANGESSKEPHENGKADDSASVTRRRRQSRRARKLKVDALAFKPEEGQSDGSDEEEGADTLKKRRRVKKRGVKRTRTEENGETQVDGAVPERPKRRRRGEQAAMEAEAPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZI3</accession>
    <name>A0A4Q9PZI3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1038234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZI3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
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    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
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    </dbReference>
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        <property type="entry name" value="DUF4246_N"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="2">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
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            <begin position="94"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
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            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
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            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="895" mass="104258" checksum="6ACC1E675E827073" modified="2019-07-31" version="1">MSQSELEFTSPFDTIIRNPLTLIELRMRWFSGKIRAKPNWWKKVYDDEIVTKWRKEMIEHDTAMVERFWGGDEYWKRGDGEKQWPRDKITVVQLNYLLDELRYDASRYDDQTGIFATAIHKVYESRSLMPADVKASLAQGVSALEDIPDEEKDWHPGSKKQVLDLVHPSMYCLRIGRSHVYRRDQGQGTSTVQLTLENYLNCRPEFEKIWWFGFAKPPCISHDYQWLPTDFERSESGDVKPLAYINNLHPIDHRAIPWPPLAVRPSPYRWYHHVAVPAPSYLDFDDYPVDKRAYHDAYDEWESKYRWPLIPEPEPFAPPNAVDEENKIKISLRGRTLQVIVKLANIVLTPENPKYAGGSWHVEGMANENIVATGLYYYACENITESRLDFRTAIGAEGRGRSLVHEQDDVQGYTAAFGLQRDRPLNQYLGYIVAEEDKCVAFPNIYQHHVDAFELADSRKPGYRKILCFFVVNPFVRILSTSDVPPQQEKWAFAELAKAPILGKLPQELYDAVLKYASDGFVSRKEAEEDREKLMKERSRFVVDHNKEVFEFTSSGKYNQVGHGLNEKALMYVSRRARGCYGPPSRRTVFVVNIDALLRLPRWLSQPPELEDQSGLLSPGRSVLKSNISFVTRRARHPPPPFWPISQRRIRVRDEVSNPPLKPPRGRARRMTEPALWYNGQYLLEKEPSTDPADLGSRLTKAAEEARTAKWEMLIANRKPREKIPPRLFGSRGRNPPLLLYGWTFNLDYFLEYAKRHRLTLEVSEEARKRLGCATKTFNFGDATEEHYRDEQLLQEMCHAARFVSVGHLRRSTGFVFEIGRPLSLEWDRILYVWKNYDIEEKYFGYGFSRKGRFEAAKKIVDEAMNECLPDGKKSELLWWWSFDDNDVNVLTSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0P9</accession>
    <name>A0A4Q9Q0P9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetratricopeptide SHNi-TPR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_319724</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NASP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0P9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0P9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051730">
        <property type="entry name" value="NASP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019544">
        <property type="entry name" value="Tetratricopeptide_SHNi-TPR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081:SF1">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15081">
        <property type="entry name" value="NUCLEAR AUTOANTIGENIC SPERM PROTEIN NASP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10516">
        <property type="entry name" value="SHNi-TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Tetratricopeptide SHNi-TPR" evidence="9">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="6">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="264"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="209"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="327" mass="35012" checksum="34E00D8308E2B70D" modified="2019-07-31" version="1">MLTTLCTTDDAANSGAFLSFSGDGEDEAVDLFAEAQKSVDETEAAAQQEEEDDEVEPEDDFNAAWEVLDLARAIYEKQQDESEEVKLKLAEVFITLGDVSLETEKFDQAITDYSAGLKLKTDLLPLSSRQIAEAHYKLSIVLDLTAGRLGDSITHAERALDSVEARLAELRAALSGQGLVKPPEQKEDAKGKGKGKATGPALLGDDAIVHMTKAQMEAEEKELQGLREDLALKVEELKTSPNEPADSAPALVAKALDQELNAGSTAGTVKQSEVHDLTGLVKKKKKNVDANGDATATASAATTKRKAEDNAEEAQTEKKAKLEDPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2G5</accession>
    <name>A0A4Q9Q2G5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-terminal acetyltransferase A, auxiliary subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_921338</name>
        <name evidence="5" type="ORF">BD311DRAFT_689031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2G5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2G5"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1040:FF:000003">
        <property type="entry name" value="N-terminal acetyltransferase A, auxiliary subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011717">
        <property type="entry name" value="TPR-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07721">
        <property type="entry name" value="TPR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000422">
        <property type="entry name" value="N-terminal-AcTrfase-A_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="581"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="621"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="859" mass="96815" checksum="D3B734BEE1DA88EB" modified="2019-07-31" version="1">MPPAGIPPSRALPLKESGLFKEVLHYYEDRQLKKGLKTADAILKKFPNHGETLCMKGLILTHLGRREEGLELVKQGVRLDLTSHICWHVFGLIQKGQKNYEEALKSYTQALRFDKENMNILRDAAHLQTQLRLYDGLVETRHTLLRLRPQLRQNWIALAVAYHLSGNLAEAKSVLEQYERIVKNVPDYDVEMSEILLYHVRVLEELGEYADALSLLDANAKSRAIIDRVAIQEFRARILSKAGKDEAQQAWQGLIEQNPNCWDYYKGYLASRGIDLEAITDEQRDQALHSLHDFSAQFPKASAPLRIALEIAQGDKFTKLVQPYLKTRLEKGVPSLFADLKSLYRSSSKRDTIEQTVTSLLSTLVHPATSPSPPDTDPTEYIWALYYLAQHHSFLGSHKKAIELLDEAIGHTPTLPELYMFKARVLKRAGDPFGAAKNMDLARTLDLQDRFLNTKAGKYRLRAGLIDEAVEVFGLFTKKDAPSPSQDLEDMQSLIYLTEEADAQLRNGNLAMALKKYDAIHRIFDVFEDDQFDFHGYSVRKFTINIYLNLIKWEDNLRSHPAYVHSAIEASRILVKVHDDPSLATKPSSESELSKKQKKKAKRAEKKVQEEAKKANQNSANEDKGLDIGPLKDEDPDGTKLLQASDPLERAAKVLKPLTTMAKDNIDAWLAIHDVAVRRKRYLQAIQALNRAHALNADSPELHFRLVDFQRRWTSLTDKPSENAASAALSAIQKLIPDEVSLEVFNSQYLQRHSSRADAVLAAAKVSRTLGAPREEVEASIFTALNADTELKLETALAIVAFLTEIRSQRAEEFRAACRAKFQLSTLFVPPEDLAAAQKAVVQKDPVADAVEEKAEIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2K6</accession>
    <name>A0A4Q9Q2K6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_812969</name>
        <name evidence="8" type="ORF">BD311DRAFT_659876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143408">
        <property type="protein sequence ID" value="TBU30094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2K6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2K6"/>
    <dbReference type="OMA" id="CVPININ"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU30094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="10455" checksum="C57BC289A7A40C29" modified="2019-07-31" version="1">MPGGSPPPSPTTVTITQTASGPEPTSACTTGSIQCCDSTEAVSATDPDAAAILGLLGVVVEGVDVLVGLSCSPLTVIGVGGGDCSSNVVCCEDNAYGGLISIGCVPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3A0</accession>
    <name>A0A4Q9Q3A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">AFG1-like ATPase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_178211</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3A0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="680"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="716" mass="79985" checksum="5258C2C638B164A5" modified="2019-07-31" version="1">MVDLCPAPFRLILSTNMRLRLIRRVTASRIGGSVISGVHTYTTKLPVQVDLLERYRGLVALGRIKEDEEQIRVIMQLRRLHRELDGYAPPALQSRYLNQTHSVIPGSAQPSSGEPLTPWWAASDPLSDKSASARGLVRIRTHAEEIEALTTPKGLTITGPPGSGKSFLIDLWFSTLPTPYKTRKHYNELVLEIYRAVWEETRRRMAAIHPNPESPAAAEEPSRPWNKLMRERWRQLLKSGSLPVRWTRKSNMSFSLSRTPLEPSIAYVVAQRLILRHWLLVFDEIQLLDVSSATLLADVLSWFWRMGGIIVGSSNKVPDDLYKNGVQRERLEPFVEALKARCPVVSMRSDRDWRAVRGNEGKNTWYTFDQQREFEAEIAEVTRNDSQTGLEEASSAEIVVFGRGIRVPWSANGVCQFKFSQLCDESLGPADYITLAAKFHTFVITSIPVLKLSAKNQARRFISLIDAFYEARCRIICLAEASPAQLFFPDAPSSEGGKDLRSYEDVDVMMAEAVGETQDVYRPNVSSYDAPNMARESTPAKTLALDTLSIFSGKDEQFAFKRALSRLLEMTSESYAKDEQWTPLPPDARKWETSDSVRPSQPSITTSPSSQPARAQFNAPSSPDLADFAEEAALSSPTPASPFPAERPPAPRLSADHIWGVREDWGKRAGDWGRGAALHGPPPAPSPPGPAHRDAFAEEPERSQGGGDKTSRRGQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3H5</accession>
    <name>A0A4Q9Q3H5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3H5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="93" mass="9791" checksum="6B27AC310287DA18" modified="2019-07-31" version="1">MFLSAHRDPSGATLHQLSINGPVNGVIRSRGRIQAILLFIQLCSPVLASAVRSSGHSAGGACPNTGNASPFAPRPSLMVTFVRSMECKKTGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3W1</accession>
    <name>A0A4Q9Q3W1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein SEY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="12" type="ORF">BD310DRAFT_873277</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3W1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3W1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="725"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="749"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="74"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="779"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="84"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="810" mass="92347" checksum="22C76E28C0DD5439" modified="2019-07-31" version="1">MATAGIPPTTLSPTKADGFTSAGRNAPATNGHYRNGSATTSDASSERIQIINDEKQFNPELTKQIEKWGLLSAGFDYNLVAVFGSQSTGKSTLLNRLFGTNFDVMDETRRQQTTKGIWMCKAKGANVLVMDVEGTDGRERGEDQDFERKSALFSLASSEVLIVNLWEHQVGLYQGANMGLLKTVFEVNLGLFGKKTPDGRNQRTLLLFVIRDHIGTTPLANLQATLTQDMQKIWDSLSKPPELKDRQLSDYFDLSFFALPHKVLVPDKFEAEVQELKKRFTEKPREDYVFSPAYHKRIPADGVAFYMEGIWEQVQTNKDLDLPTQQELLAQFRCDEISSAALAEFNEQSKSQKRPIETGKVVEGLGKMMRAWRSQALERYDRDASRYHQGVYKRKRVDLIGVIDSTLSALFLGQLKNLHKSSLASYKKEMLDGMRGEGYNFADVVASARARLEKRFLQGAQEALVEGTDWSYEEELGLLREEARIVADQCRKDETKKMVNVIERNFKKQISEPVDVYLNQPSPDMWDKVLKVFRETLDKAESSYLTKAKSFDCTDEENATALTTLRKRAWLALRAKIDEQTADTIFLGKLRNYFEERFRYDESGTPRVWKPDDDIDTAFRKAKEQTLELVPLYWKIKPLDLSLEFTLPSETSDSLTSTEEFDFPSTLVVFSETKALDLTNRFRKDADAYYVEAKRSMVSSVAQIPYWMYGVLVVLGWNEAMVVLFNPLYFTMLLILLVSAYVIVQLGMTGPVLQILKSLFSETHRQVEGRLRDHFSQPQLAQPVRASRSRSGTSNDEPERDVRRRNVEPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q430</accession>
    <name>A0A4Q9Q430_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_844475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q430"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU62083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="218" mass="24467" checksum="8159C5C40D83C0B4" modified="2019-07-31" version="1">MSAPCQVCFKPSTSQCSTCKFARYCSREHSVSDWKRHKRECPTLAAGLDSQIGYPLTVKAAVFPVEGGEPRIIDLPYKLLEDGHYPAHQLDLTPVLGGATPDRTRIEIAGFDVGPPLGHRLILIHNDNFLAEKRAVNMGIQAIHKGRGYKWCDNLLVVRNVNKRERAWQYQDITPADVEAVLKRYFEQGSDGHAALEYADAVEESNWLRDMGSQTMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4M2</accession>
    <name>A0A4Q9Q4M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_872921</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4M2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4M2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21720">
        <property type="entry name" value="MIOS_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="774"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="1050"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="557"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1141" mass="125137" checksum="2D2542C878F65EFE" modified="2019-07-31" version="1">MVAQSDKRLIWHPRGQNKFIVGGSTQITLYEWIPQSTDIKQVASQSELNQMKCFAWSPDPILDDLVAVGFSNGRVELVRFEASKHARNSAAVSLPPARNTRACNTLGFSPANPNSLAVGLDKVRNDPSLVIWDIHSALPALSLFDTGSHGDIDGDDSTILSRGDDHTRTSSDPRPVQHYASAEVVSTLSWLPQNPQLLLAGISHRWLQLFDTRTTASPAKAASKVHGIATDPFDAHRVACYSEGIVSIWDIRRFTQPILTFTSKDASADGADGVVAAHSSSRGKGAPSSSSAVVPLAHVEFSSTRRGTLATLEREASHVRFWDIHQAQYFELSVESNRSRDSSQSGGKATRTSWVKPWAGGGSTATRPSSPPVPVPGEFSQYHLVLADTRRTKTFSHPFTSFALVPSPKPHPLTSNVMLVNRDGDLELYAVHDTPIHPPWSSRGDLALGIGCSYTVIPGITDPTPPREPWELLAARPSRPGSRAYSLERAADSTFHMGAVGDSPAMFGRGDEDGFPALTPNAASVSRGHSPGKQRFRHLTAESALAVQELPFEHTAVVRGQPPKRSRRGGDHDVERGRSVPPTTPKTVTLALDDGEGKGRIAKKSHAVKALQHVVESDISMLMRKRAAFAYGLIDPVYNSSIANTTNPHNPSLSELWSWIQHSQRLVFSPSPIIEGYNFAYQGLIGIWEGFRPIRPSPPSGQPTPRMPARSALFDGPSASPLLIPSSLELPPRPSSKHTSRRRNQVPTSSLPEDFLNAIDELNMRSGSSETWKPSVSTARLSQRRFALQLCGWSLAQDDLARAIQKWEKEGKYSQAACWLVFTEQNKPAIETLMRSKDESLHMMSGMLAALTASPSRNAELVQHCERLIVRLQDPYLRALLTHLTVRDWSEVLEEDSLPLRERLAIAFQFLDDKEVSSFLRRTADRAIHDGDIHGVFITGLTVAGIELLQAYIDSSGDVQTAALVAALSPTLARESRATRWMNAYRDMLDGWRLFHHRCHLDIERGKILKEAVEYGEIQSFDWAPKQVLLRCNYCNKPIEAPFSSEANPRATLCPNCSRPLPRCSICLMTLNLAPDTGRGSTLSAIPSDTLQEALVFCQTCRHGGHASHILEWFYGEGGAASRAHGTCPIAGCECHCGNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5I2</accession>
    <name>A0A4Q9Q5I2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5I2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="315" mass="32896" checksum="4E894E95003D3CC5" modified="2019-07-31" version="1">MSHHRNARDVLFGPFFPSILDPLSTGQHNLTPLSHTPTKTSHSSSPSSTTTLHTSSRSSTTGTQGDTSSQLHATSSSASPIPTAVVAIPAGIPVPSTSVDIFTLSQDVTILNTITENITSVTAESSSSSSASIPSFPPAPSPTPTPPPQVSVQPLSSALSHGAVGGIVACLLSLVFLALAALLWHRRKRASAVHVVQADDMRSIEGPRSSPPSTFVTVDDKRGIQGDTSSFPSVSLNRGARPSGTLDGLVASALVLAHQMPVREVDARSVHVSEYWDDRHSDIGGTSGPLPPAYEDVPPRRPFPSSQTNGLRTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5P8</accession>
    <name>A0A4Q9Q5P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_956420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5P8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5P8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="83"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="407" mass="45737" checksum="CFF898F7BFBA94C6" modified="2019-07-31" version="1">MAPKDKQATVEEFRELLASQDLIREGDTIGTDDETLHRFLRARSYNLKNAATMWKNCLEWRRTVEDRGIDQLYRDIDPFDYPERDLVFESWPLYFHKLDKEGHPINIHHFGRIDLTKLGGKMSLERFWQTVLVNCEALPREVLPAATEAAGKPILGTCVVIDLSGFGIGQFWHMKDFARSSFQVSQDYFPETVARLAIVNAPRGFTAIWNVMKPWIAKETAAKVTIMGSDYKSKLLDFIDADSLPTYLGGACTCDGQGGCKKSNAGPWMHNRRRRRELWLEGRRDTCAIKPGELGQEQVSEDAALREEDERAPAEETEAGTHTPPTQRKELSGSTSETSSVETSSPTTPSFSVHEDGDSHPDPHKLDGPPGLSQEKSVDHVYEQHPETRQVQGGALHKEAPVQVVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5Q9</accession>
    <name>A0A4Q9Q5Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5Q9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020509224" evidence="1">
        <location>
            <begin position="28"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21738" checksum="FE6017CB3175B87D" modified="2019-07-31" version="1">MSFKRSYIIAAVLVNVLAIAVTSSARAAPGGVKLAAFRDELDRPVYSWTISEDEKDRLTALLETDFNEANVAGTYVNAPPQACSHCGKETEFIDWVYTALTRGVHSPEFIVESLKEGNIPKNVHHDVYCSRCGHLTAARDHTGSEGGSLHIAHATPYDRATRTFGDSLHKWDGAGLEGRALVWHTLWTARGLEDAASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5T0</accession>
    <name>A0A4Q9Q5T0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="3">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_918166</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer. Also forms a small population of homotetramers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="3"/>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5T0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5T0"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="235"/>
            <end position="241"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU62783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="539" mass="60093" checksum="54A438E978A08F76" modified="2019-07-31" version="1">MAEIHDQFDTILILDFGSQYSHLITRRCRELNVYAELMPCTQKIKEVKFRPKGIILSGSPFSVYDKDAPHVDPEVFELGVPVLGICYGLQEMAWNMKGKVAKCEHREYGFAQVEICKIGGENKGVDALFKDLGDDLQVWMSHGDQLSELPEGFHVIGRTGTAPYAAVAHSSKPFYGIQFHPEVTHSKRGREVISNFVVGICGCRQHWTMEEFIGKEIARIREICGPKGRVIGAVSGGVDSSVAAKLMHEAIGDRFHAIMVDNGVLRLDEAQQVHEMLNKDLGVNLTVVDASGLFLSRLEGVEDPEQKRKIIGNTFINVFETEAAKIEAEAEKEEAKGSEAKGKIEWLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLKDMKLKLIEPLRELFKDEVRALGRLLSIPNHLVQRHPFPGPGLAIRILGPVTRDQVKILQQADSIYIEEIRKANLYDQISQAFAVLLPVKAVGVMGDARTYEQVIALRAVQSEDFMTADWFVFPAEVLRRISSRITNEVQGINRVTYDISSKPPATVEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6B8</accession>
    <name>A0A4Q9Q6B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_810604</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6B8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020421979" evidence="8">
        <location>
            <begin position="18"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="496" mass="56053" checksum="A47AA4F28E8692E1" modified="2019-07-31" version="1">MVQPLLILLLCPLGVYLWHRYRDPLNTIPTVGGPSLPLLSYIGSYRFFFRAQELIQAGYDKYRGSAFKVAMFDQWLVVLSGPELVEDVRKLPDDVASPGEGVLFLTQVGKYMHPEVLADHYHVDLIRNTLTRQLNAVLPAIVDEVEVVCGELLPTVEGDTASLPGSKTVLDIVSRIISRAFVGQPLCRNKQYLDAAVSFTIDLVKARIVINLFPERMKWFVSRFITGPSKNLRRVMGLLLPVVNERMVQMQQRETKTESTDLPNDMLQWILEEAQERKEPLDYVAMRLQLQNFAAIHTSSSSLTHAFFHMLSRLDIVPVLREEVESALAPQGWTKTALDKMWKLDSLLKESQRFTGITLLGMIRRAVQDVKLVDGTYLPRGTLFAFAGQATHTDTTNYDGADEFDPFRFADVREGGDSARHQYVNTSSDYIAFGRGKHACPGRFFASMELKVVLAYLILNYDMTFEGDAGRPANINLSFSVIPSRDAVVRFERHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9C8</accession>
    <name>A0A4Q9Q9C8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c oxidase subunit VIa-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1035411</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome c oxidase subunit 6A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9C8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9C8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.95.10">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001349">
        <property type="entry name" value="Cyt_c_oxidase_su6a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036418">
        <property type="entry name" value="Cyt_c_oxidase_su6a_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE VIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11504:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02046">
        <property type="entry name" value="COX6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81411">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit VIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14273" checksum="5FF269D3EA715D75" modified="2019-07-31" version="1">MSFVIRRAALRAVPRARGFAAAAGKGSYHEQQQALVAHAAETTELWRKISYYVCLPAIAAGALWVRQVEAEHEEHLHHRIEENGGKLPEPPAYEYLNRRTSGAFPWGNNTLFFNPKVNKDMEAASEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9G0</accession>
    <name>A0A4Q9Q9G0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_806162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9G0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="316" mass="34412" checksum="A525E0294582E848" modified="2019-07-31" version="1">MVNSIRRRGSLPAASARAIRKTIGLPRSKSFMWPSHAAPDERQPPSLPSVSRDFTLVSNPSSQDEIEYTPAARPRVRIPRKSSQQPAAIDTDALSAVDECPIQDREPELKPSNDMQNQTQITLAGPVDSSSSPADTSAPPSKHRSRRRVKGPRPRPASMSAAVDGDGRRRYARPARPDNSIPHEIFETRFENPFSPRSWSATLKREKGSASDTSSQASCTSRRLSVFGMLSTFRRSLVKKSDGDESPRDPSPLSLDSSASSTGASVSSASSRSRWSFCMRNGVPRTDPYGPPYFAQPPIPSADADRGRRAAGRIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA83</accession>
    <name>A0A4Q9QA83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">S-adenosylmethionine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_839755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic AdoMetDC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA83"/>
    <dbReference type="STRING" id="114155.A0A4Q9QA83"/>
    <dbReference type="UniPathway" id="UPA00331">
        <property type="reaction ID" value="UER00451"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004014">
        <property type="term" value="F:adenosylmethionine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006597">
        <property type="term" value="P:spermine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.90.10">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048283">
        <property type="entry name" value="AdoMetDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016067">
        <property type="entry name" value="S-AdoMet_deCO2ase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018166">
        <property type="entry name" value="S-AdoMet_deCO2ase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11570:SF0">
        <property type="entry name" value="S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01536">
        <property type="entry name" value="SAM_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56276">
        <property type="entry name" value="S-adenosylmethionine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01336">
        <property type="entry name" value="ADOMETDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="49512" checksum="D2609E0AD66BA51D" modified="2019-07-31" version="1">MFADDQHTASGPFEGPEKLLEIWFASSPADIPDAHSSTDGKYGLRKVPRAVWEEMLDIVKCKILSVVEGMEMDAYLLSESSFFVSPHRLILKTCGTTLNLLGVPRILEIARDAGFPTVHRLFYSRKAFMFPERQQGPHREWKAEIEFLDNLFPNGSAYTVGKVNGDHWLLYLTAPGELSSGSGDTAPSSPQSVLHNVDGVDPEASDVSPPDTPAEEREDETDDAIASDYTIEILMTHLSPEGRAPFFSNSSPEDGDATAGADALALSSDIGITNIFPSHITTLDAYSFTPCGYSCNALLKWRPDAGQDPARSGEGYYTIHVTPEEGWSYASFECNVPLATKPTNKPTSVPDLKTLIRRVVNIFHPGKLTLTLFISSKDNDAAEEDEGETTVEAAQRAFKAALTLPAHARRKSEGEPQCNGTEAGAAGLYKRTDKINYEFGGYDLAFASFELRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA96</accession>
    <name>A0A4Q9QA96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTPase inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_915109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA96"/>
    <dbReference type="STRING" id="114155.A0A4Q9QA96"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="230" mass="26290" checksum="8E7DDE1EB63FD18D" modified="2019-07-31" version="1">MSEHNAKVASLVARLNEPSTSEAGSSRTPATEIDDDDIFAELEAEIENDSSAAFREHGMEQLKREMEQLQKMKSVGHGQYREVTDEKEVVQLSANEPRCVIHFFHHKFKRCEIMDKHLQRLAPKYFGTLFIRVFVENVPWLVERLGVKVLPCVMTFINGTSKDRFIGFEDLGNSDEFETATLEWKLINSGVVQKDESFGPSVTYGTKTAVRQHIRSRDTEDNDSDFDLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAS7</accession>
    <name>A0A4Q9QAS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_805783</name>
        <name evidence="8" type="ORF">BD311DRAFT_773059</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAS7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAS7"/>
    <dbReference type="OMA" id="WPSSANT"/>
    <dbReference type="OrthoDB" id="88at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039927">
        <property type="entry name" value="Ribosomal_mL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21396:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="7">
        <location>
            <begin position="41"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU34868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16912" checksum="4274C429B0AB9FA6" modified="2019-07-31" version="1">MASKLAPAIKPFLRGHQHSLPANGHGAFIPQIRKLVFEFCDNWTSSANLRTYIHNHLEHVARANPHVEFVVRRRSCREPVIRGFYINNRDKVVGLKDFEVTGIEKKVQLLLDSSGAKIKPLKRLTVESRTEAPRGIWSGLHVEEPFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAX6</accession>
    <name>A0A4Q9QAX6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_943733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAX6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAX6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010708">
        <property type="entry name" value="5'(3')-deoxyribonucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052419">
        <property type="entry name" value="5_3-deoxyribonucleotidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35134:SF2">
        <property type="entry name" value="NUCLEOTIDASE YQFW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06941">
        <property type="entry name" value="NT5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR610708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32783" checksum="F8402BC148CF686F" modified="2019-07-31" version="1">MAATLEPKDDPKSHLTVSGHATPRTAARPGTILEDFKNDGRPVIAIDMDDVLSQTNEVVAEWHNSAYGTSMTLDDFYYYYYWMNPYWGDPDETIRKVEEFWKTDYIDIAPPVAGAYDALLKLTEKGYRLVVVTARQLRELDRSIVWVEKNLPGLIDTFICTGQSMETLADQKELATKLSKADVCRKIGAKFLIDDSVENALKCVVADPPEPVLLFGDYSWNTRVGRYSDITKETSFEEKLKREGGREFWKEDSAALEKEIPPSAPLTRVKDWKEVLEWVEKKTAEGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB69</accession>
    <name>A0A4Q9QB69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/ esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_916115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB69"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB69"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="331" mass="36356" checksum="C07AEFCABCAD5B30" modified="2019-07-31" version="1">MASERPVLQPIHPQTEARLLKEYADFHRQHIQHTPFLHDLPWDPAVRAAPAVQGGSEPLPVGNVQDYALSKFSVRVFTPEGDAPEGGWPVFIFFHGGGWTLGRIDTENSFSSNMCKRANTVVVSVDYRLGPENPYPAAVEDTVESLQWVYNKGKELLGVNPSRIAVGGSSSGGNLAAIATHKAAELGIPVVFQLLVVPVVDNTAQVDDDRYPSWKENERTVALVPGRMLWFRDNYTPNPEDHTKWDNSPIFAPEELFKKSPPAWIGVAELDILRDEGIAYGEKLTKAGIPAEVKVYKGAPHPIMAMDGALEIGRELVSDAANALRKALYTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC73</accession>
    <name>A0A4Q9QC73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_972399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC73"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="56968" checksum="337CE4F24DC2B81B" modified="2019-07-31" version="1">MSYYGGFDRRHISRMMRTSSTLYRAGSKHLLKDGVLLSEERQLRSFCRFMLAEKQTRFRYLRQLTLIMDRPSQAVAKKFVYVLKRMAHLESLHLSADDEFLNGHPDLCDAISGLASLRRLHADDAGKLACDMLKRSCSKLVSLYLNFGMVPSFPGDRYGEFFYNTLDPEDLPDYHPVSVLAAFAPTLEELIVEYEGNVRLPHQPHAVYPRLRKLHLKDDYPFLRPYIDAFPNLTHITLHTSHCELSVPYEDHEEVFWEIRSRNEGDQLVNGSWQHLEEYRGPVLELYLLGLTCPVPHLYFPRIADQDLEFLPDVVDSARPVELRMNIRGDPFGDTEDELPAVLRRPGCSFLRKLVLRVEIPPEYEESDIQISMDNLLPSLQTLALHHFELTLEPNRLLNPTPRRGRPRLTLPDGSLEPPITPAPLFPVEHSLEEFNPLDYAQRVFEAVPFMKEALVVVGGPRAAARRVTRLERGEGEATVATNHTEIMDYAPWASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCK7</accession>
    <name>A0A4Q9QCK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_911249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCK7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCK7"/>
    <dbReference type="OMA" id="ANGVMQY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001129">
        <property type="entry name" value="ras-related protein Rab-44 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="219" mass="24132" checksum="EED9E6B5780170C8" modified="2019-07-31" version="1">MAGVAWHYVLKFIITGDAAVGKSSLLIRLTDQRFLANPDPTLGVEFGSKLITIPEENKVVKLQCWDTAGTESFRSITRSYYRGAAGCLLVYDVTSRQSFVNVRSWLQDVREHADPHLTCILVGNKIDLCTDDPNAPAPKRKREVTTEEGELWAQEEGLLFLEASAKSGENVEAAFERATRDILEKVRRGVFDDDRSPGVKLSKPSSGVALDEQAKGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCW8</accession>
    <name>A0A4Q9QCW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_867630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCW8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043422445" evidence="3">
        <location>
            <begin position="25"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="317" mass="33871" checksum="764AEDFA209B88EC" modified="2019-07-31" version="1">MRVQIPNWYLLALLHAVFASSGRAASLASRSIKLYVRDDDDDGDDSDSDDGDDSGHARHHGGSASSSHGLSKGAMVGIVIGCLIALLLLFLFVVCCIRRRRAKARKQAQAAAVTAAAPEMKENLASTPLLVQHPPNLRPRSTIASSPTDIIPGPLYFSDSIGRRATQEYRNVAPPTDDSAPLPNPYDGDTPPQPPTRDDFLSSPTSPSYPTSPYASSASRISRRQSTAPSAWTHDELHSDASSGSGSGALLLARGGTQTSRLTTSSCLHEEIAGYQKALEAHYRKESEDAVMREHRIGEGSSVPADPPPMYSPSVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDT1</accession>
    <name>A0A4Q9QDT1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_912227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDT1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="99" mass="10985" checksum="7E4BEB6494E01CD5" modified="2019-07-31" version="1">MYQLTSLTARPVISIQAPDRLFPTARHAYPPSSLDRPKQGAPAQSPSRRARMLCARIARRGLLGPMSGYPDIALVRDVWEVDTPRARAIRASETLTTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K3Q0</accession>
    <name>A0A4V2K3Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_832893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145266">
        <property type="protein sequence ID" value="TBU52099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K3Q0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="702" mass="79005" checksum="BF688AE31019693F" modified="2019-07-31" version="1">MPKTAAARVLHPSHGKYLPSRCVKRSRTCYESALNLTTIQDLKKEFRETYSQEDKDEALKSTVEVVKQYSDEMVKRWKEEIDTLLVYAGLFSAILTAFNVQSYILLQPSTPDPTLAVLQQISLQLNSFSVNPPGALVNSTHPVTPFAPIPTAPVEAWAVWLNSLWFSALICSLASASVGILVKQWLHEYEAGISGTSVEIARLRQYRLNHLEKWRVAEIIAILPVLLQVSLALFLAGILVLLWHLHPTVASVASTLISLLLSFVVVTTVMPVFWRDCCYLSPPTYAIFRAVHRIHFLVTSLRKLFKALYNCCDALINLEWLPVFIRSWFSELRLWAMRQDWNTVTVPTWRGRERTAVQSSASELDVDMIAQAYSTTMNVNYLSDTAAAVLADKDTDAVVRCFAMIADINVRHFGHWHVRMRSPNFWAGALIHVSRKETCKSLFDHLIIYRSWYLGKRQSEHHSRLVLASAATVANADSGPDVCRQSLWLVEHILRFTPAALEAMPWGVVHHLAAAAEMRLRQLLHPGPSDGGPGEEPEWDSTVFLWLRILVKCWFAPASLCKRTQEETEASTAWVFGMDFLQKGSISKMAGKLSWSYPAKAMLESLDIILTYLGESEDARRTAPGDSLEAIGELVEYIEGPSRSADFWDDEDVQKALKELKRSLERCKTLRLGIGAEEGRIQASQPNRMPGLSAICERPEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4M7</accession>
    <name>A0A4V2K4M7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_915050</name>
        <name evidence="2" type="ORF">BD311DRAFT_749770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4M7"/>
    <dbReference type="OrthoDB" id="3230513at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU32813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="302" mass="33150" checksum="B96349996EAA6337" modified="2019-07-31" version="1">MSPLSLPNNMGPQRRNVRRKPVPRLSPDTTTAPPLPARGLQRLSLTININKEVPPLPVEWSDTMEHASTHDRRHAVYLRNSLPPELPPKDDESVAGSRPESPNSTLVEELEVQEGFTPVLSPQSESLPVQSVECTLPQPTPDVRRRASQKSLPKIYRPPTPPIPAQYPKLRSGGHSRASSQDSQTHIIYNGHVSAEQRDSAPPSSTLTSWPGRLGTDVSVTAHSLESRSNVLSFAGSKDLPPRRGGTSPHVRRQSAGSMSTGNRSSTGRSQFTCHSMCSGMWYALKRLGLHLRVKVGHNTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6A0</accession>
    <name>A0A4V2K6A0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_942118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145316">
        <property type="protein sequence ID" value="TBU51483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6A0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7513" checksum="DE33C9182D3F4893" modified="2019-07-31" version="1">MTAYSPYSGAEFVYSDAASPYRLLRRRVPTLLLLAVFSLAACSSSHTAAPAQTMARYGPPATSTWRMPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6C3</accession>
    <name>A0A4V2K6C3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_834420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145326">
        <property type="protein sequence ID" value="TBU51413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6C3"/>
    <dbReference type="STRING" id="114155.A0A4V2K6C3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="137" mass="15669" checksum="AA97E08A0153C0EC" modified="2019-07-31" version="1" fragment="single">IQTLNLHLPLLDPLHYISPLAALLEFGNEAHQVAMDAWSVAETVRVLRFADSRLERCLKQSGKIPNGALYLADLRTVWLEEDFDSPVYTEGKERKENERFNGAAPFTHHSTSFYRPLDLALHEHKLFSLSFPDQGEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6K6</accession>
    <name>A0A4V2K6K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_889296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145247">
        <property type="protein sequence ID" value="TBU52533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6K6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020615922" evidence="3">
        <location>
            <begin position="21"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="17765" checksum="1B8D7C44EDF07FFC" modified="2019-07-31" version="1">MRPFAIVATVLACCAVYVHTQTTTVIDDDGQTIVEVITVDPDLGLPTTETLETLTAAATTTTTTPAQAAGPGPVGQPQTQQAAGPTIYTYTTTDAAGNTEAVVDTFTPSFGPTTGGSITAAPGTIINYSSWRASVGSNTVAVVSAGTSRWTVDKRWAGIGVALCAGITGGAWLALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K725</accession>
    <name>A0A4V2K725_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_935818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K725"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="37503" checksum="F029B8FAFAA91872" modified="2019-07-31" version="1">MSLVHAAHEAEAAEAFRNIPIVDLKDIDSSNPVVRAALADEIRDACMNVGFLYVTNHGITDTIIQNALTASKSFFSLPLEKKLELDMTKTANFKGYNPVLSSNNNPENNGDMHEGFEFGWEEIDARPDDEKRANDGVMAGANVWPSDCLEFRESVLTYYHAAVNLGRKLFPLFALALNLPENFFDDKTKNAAALMRVLHYPPQTGPVDDRVIGIGAHTDWECFTILWQEPEIQALQVLNKQNKWIDAPPIPGTLVVNLGDQFARWTNDVFKSTVHRAVNRSGVRRYSIPLFFGTDYHVRLEPIPSCVSPDRPPKYEVVTAGEYVKERLKATYGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K733</accession>
    <name>A0A4V2K733_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1041714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K733"/>
    <dbReference type="STRING" id="114155.A0A4V2K733"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="176"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33523" checksum="7BF0CEC191936806" modified="2019-07-31" version="1">MDNPSSGLNSTAPALPVLPSLGSTFGAVLLGVFFSLILYGGILHQAYRYYRTYTTERLGLKTLVSATVLLETGHTAISMYICYRALVTDYGNPASLSNVTRSVDILPALSGLIVALTQSFFLRRAYLFGKQYRPWALLVLFPLVAGFGFSLASTVDGFAWFSSYDNREAHWDFLTQTDSMLDTLILYTVTTGLLTSACMLLVFVFSVATPHNLIYIAFSFLLTKLYTNSFLAALNTRQSLRSDSTVHNFGTDVFGSGPAMELRSGPSKASRHESNAVALELTERPASRQFGKISVHTTTTYESGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K786</accession>
    <name>A0A4V2K786_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_1041335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K786"/>
    <dbReference type="STRING" id="114155.A0A4V2K786"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="60"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="522"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU55168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="550" mass="59935" checksum="DE33C595DE64B5C1" modified="2019-07-31" version="1">MTDPQWVPTVQDLRVKLCYICREEERYDSASEYLILPPSLPGLTLPSRTEPLAISLDIPSARLPNPTSHLAQDPEDPPRAWTHPCSCTLVAHESCLLEWIKSAQQDSSRAGNALKCPQCGATYELESDNPRILRLLNAVNAGLSAAGKAATVVGFVGLTATFGFTLYVVSTSYGAFAVKEFLGEEMYNVLLTDDPSVWPWHAFIHLPIIPFSLILSRTRLFDTFPIVPLFLTWSSSPPARATSPSSSLWTFNRTGAPYAPPPLSWPPTPIMGMILFPFVRITYRRFFNKLTRFVMGTHADAASRDGGPIRRVIWALNENGPAPLRVRIGANIQPVAGQAVPRAGGAGAQDGQGEPAVPPEGEGNNNLPDDPAAVAERTLHVTTSSLGRFVGGALLVPTISNRMGKLLYHLSQYLPWLRAFLAIRDRPANVPAQVGLFGAPVGNSHSPLRQIGAHLATGINIMFGGTPTWNAQDPVWWRNTVGLGLFVFAKDCVRLLHLYLTKRELESRKVKNRSFAGVDIRELDLINPPPESNASSTTEPQPAPAPDVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K792</accession>
    <name>A0A4V2K792_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polysaccharide lyase 14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_934247</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K792"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048958">
        <property type="entry name" value="Polysacc_lyase_14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40124:SF1">
        <property type="entry name" value="DISAGGREGATASE RELATED REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21294">
        <property type="entry name" value="Polysacc_lyase_14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020677986" description="Polysaccharide lyase 14 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="3">
        <location>
            <begin position="215"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide lyase 14" evidence="3">
        <location>
            <begin position="571"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="614" mass="62855" checksum="CD19EB0CF467E970" modified="2019-07-31" version="1">MALTVVVLLAGFAAFDALAVPLGTDNTTTPATYSNAPISAVASSSQGLPIPITPTTSEPGTAASTSMSAQAVVAPTLPAGPATTFVLSTVTLPASTVTVTGSPQTVTDTITIIPPPTPSSAITSTTTTTTIQPTTWSAPPQMTDLSAFNVQNFASGERNMRIIVSDPPIANVASLPSSPAPPEPDPIGQTLTEAVIAVVSAVTSGLIPPPPPVTSSSFLQLFYPANSINPGQQPAGGADFYAAPLDLSAARNVSLEYSVFFPSDFDWVEAGKLPGMYGGHDGCSGGDDAIDCFSTRLMWRGGGLGELYLYAPKDKQTPALCATPPESVCDADYGLSIGRGSFRFAAGNWTHVKQTVVLNTPGQQDGAFALDVNGVRVIDRHDVFYRDVPGAVSRRDVYSAPAADTETEDEDGRPSVDLAGPDLPAPIKQAVSPPGTLDAEMVYDRDGTAVSPDSLAPRDFAPSFSSMSSLAPWIAGGSSSSSDLPLLPSSPPSPASAAAASTLPGAGAGVAKFAPPSLPPPLSQSLVTVTGTGAVTVVPPPQTVSVTPTSTATAYVVAMESGGPLPVTIGMKATEPVGFIGLFFSTFFGGHEPRYATPKDQFTWFKDFAMSVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7C2</accession>
    <name>A0A4V2K7C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_677537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7C2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10577" checksum="18B0B201F26B29AC" modified="2019-07-31" version="1">MRERSFALSSKAQAPQSKRPCRNPQRAPEPGRLRPEGWLQMRARPRRNLGTSPKSMGPVSGATASMLRKATTSLEPASDIQVAETGWQAGCSLYAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7U9</accession>
    <name>A0A4V2K7U9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_546324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7U9"/>
    <dbReference type="STRING" id="114155.A0A4V2K7U9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="39628" checksum="BF1A3363B9B8969E" modified="2019-07-31" version="1">MPASTTGKVLVTGANGFIAGWIIKDLLEQGFIVRGTVRSLEKAEGLRKALSAHGDRLEIFVVEDIAESGAFDKAVEGIDAIVHAASPVHVLANDPEELIRPALQGTTSILRSASQPDSTVKRIVVISSLAAIVDISAPTPVTFTEANWNEHDVAEVRDKGAAAAQSAKYRASKALAERAAWDLFREGRDKGTIGWDLVTLCPPWVFGPVLGVQSPNDLHSSVKTWYEIAVKEEGEIPAWSKAYAGFLSAIGSTSGILKSMCRNWVDVRDFAAATRLAITKPEAGGERFVVCTAPFDWGQWVYVARRVLGKSKPEEDIQDFSQIVHDVRFDNKKSREVLGITYHEDMEGTAAFMIQDFKEKGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8Q7</accession>
    <name>A0A4V2K8Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_251326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8Q7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15558" checksum="8CBFC02053C12448" modified="2019-07-31" version="1">MRAALALSMLIQTCQIAYQDRLSSSRPYATSNSGLYPCVNIGHPHLQHAFQAPGPSHNALLNTDFALHHGVLCPVRWEALRSSSTSEASTVVLSSLASHTLRDRAAEPFPLQALYTSRREQPSLAIDSHCRRRRRGANANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9D9</accession>
    <name>A0A4V2K9D9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1035738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9D9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="2">
        <location>
            <begin position="16"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20826" checksum="D5420A97D1EEF570" modified="2019-07-31" version="1">MCAPDSRQHVISFLEDDPLRSDVVSAASGETLYSITTEAVGLRKDTTILRDAQGNVFAGWEQKSFRRDQVTFHGVRCKLSEWLRKKTILSSTRVLVAPDGEEFHWKEKPTTFELVSTRTRTPIARSHNAHSAVGQLLGLSVAPSAVPMLDAILLSFVILEQRRREELGRASATGGAAYTASGTSAANVSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M894</accession>
    <name>A0A4Q9M894_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_952532</name>
        <name evidence="2" type="ORF">BD311DRAFT_674337</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143510">
        <property type="protein sequence ID" value="TBU23255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145238">
        <property type="protein sequence ID" value="TBU52757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9M894"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU23255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11242" checksum="92089EC3B5FA2D8F" modified="2019-07-31" version="1">MRHSRPNPIFPSHPSSGIAPPKTASACLVSQGLCAPSHGPEDSAPSLSYGHGQGKFDTRVPPHAPDKRRRRSPNWQGASYPYSRGHTSECYQLSSLSHRPLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9M8K0</accession>
    <name>A0A4Q9M8K0_9APHY</name>
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        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="3" type="ORF">BD310DRAFT_923144</name>
        <name evidence="2" type="ORF">BD311DRAFT_768503</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="3466517at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="24"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU23385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="368" mass="41171" checksum="5EF5B36F2DD6594D" modified="2019-07-31" version="1">MRALRLGILKDSGAPEGSIDYTTIVLLHGYGWHSGVFAKLVPIAGRFNARVVLVNRQDYPGAEPFTLEERAELLKAAIELKTNPLSARDRLDVFMKGQAREIYDLLIHLVAEHHIPPARPEANTGGIIIGGWSFGASWMTALLANVASFPVHDIELSRYVRRVVFYDTSDVALGFPTLPHVYFPLTDRTIPAEQLAQLFAEWVTAYFAHGDTPEQYQSRHYLASPPPTLTSMTDEERQFIQHHVPGDSRGGSDHLLMGSGYESGLFATLRKNALRLPPPNASLVGDAWRDVEVRHLWCDHSVWLIRWGEVSMRRELEEERKAGVSLRPVSFVRVRGANHFVHWDEPERAIHAVLAAVPADGGEIEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MEF7</accession>
    <name>A0A4Q9MEF7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_916425</name>
        <name evidence="4" type="ORF">BD311DRAFT_668987</name>
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    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU25705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9MEF7"/>
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    <dbReference type="OrthoDB" id="3257643at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU25705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="145" mass="16776" checksum="287D1EBB64A8E888" modified="2019-07-31" version="1">MTPSTSPTDSQRDGSADHTSPSSQHAADRPERSRNAKAQARHRAKRKAYIEQLEQTVTKLQSVLALSPDQVAAIPPPLVRIRELEQENELLHREVEELRRQLEMKNAQLRPDFRRDTYTPLPDDRHFDRETKRRRTTDANGVYVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MIF8</accession>
    <name>A0A4Q9MIF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_926905</name>
        <name evidence="3" type="ORF">BD311DRAFT_468243</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143453">
        <property type="protein sequence ID" value="TBU25942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MIF8"/>
    <dbReference type="OMA" id="RIWYMSR"/>
    <dbReference type="OrthoDB" id="3341077at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
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        <location>
            <begin position="300"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU25942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="35590" checksum="A7F3D12D2060DA11" modified="2019-07-31" version="1">MVHLTNDLTALIGFACEATLWGGYAILFIVSIILLRRRSLKTELSTPVVVAHVALFIACTVHYALEFNHFYTTLAAKGVDGYANETTQLVGADIFLSLCDLLGDYILIYRCWALWGRNYWIIALPSMCAIAGFACIMQVVHYVVTLDPTSPTPPKPMLPLTLAGYSLPLCTNVMATALIIARIWWLSRPTPGTEGAFRSARAISRSAMATIVESGALYLAIQLTYVVLLSLENPVDAIVAVMAAQIYGIAPTLILIRVMLGLSVETTMEPGAATPMVWASVSKRYTTTHEQSKMGLSVDTGGSTAAGSSSTKVYHTDSDSVEMKPVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N1R1</accession>
    <name>A0A4Q9N1R1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_856027</name>
        <name evidence="2" type="ORF">BD311DRAFT_711845</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N1R1"/>
    <dbReference type="STRING" id="114155.A0A4Q9N1R1"/>
    <dbReference type="OrthoDB" id="2562444at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1060" mass="116619" checksum="63A0504DAFAB0271" modified="2019-07-31" version="1">MSAVGNGQGSLHTLMMRSSTPASNEKVLLYLEGLNKNPPDDDMRSSLTTSDVLRSPRSKSKAASSVRQLEQLAGDDENGGEDIRSDVQEHASELGRTIPIHTTGIPDHEPGPGDPPGPKFESYGSSFGNFGPLPRESFNGRNGIASPSKAAAVPLPETTVGSPGSPTESHPNPFSQFGMAPVTTTGIAGAASYAGAPSGVGSRSRHATSAKASQKAPSVAENGVVSPKSASRALSPARTGTAAGAAPDRPWSPRTAASQNQSVKSRNTQKTQRTQYPPLPESVLDDGQRTNKAYSIAPSESASQIGTRRLRQQQQLLEQQQREREEEQRERELESQRQTARTPSHKPTKSVKSTTEVNGHYGSGGTGYAKSQSAARSQAPMSPRSQAMSVSRERSVAPTEGARSVAPPMSPARSRHTAHDPDTTPTPSRAATPENPLSAEEQRLVQSVLDVPRTRTSYALSAMAPSALEPEVQNSHFHDMELCQLLHALDQPMGEPVKKAVRKAVRARVKKLGMKYDNESIKAYRKSYHDHDPTVHLIPLLTGASSKRSGVGPAGQEPPEWAKELLQGFINMQNRIDALAPKIEKSLRSSRGGSYVTERANYSNGHQHYEGSEMDGGYEQSQMTQDIHQHQTGDESMYVSGEGEMIRDSTHLHTLPGSMHHHDGSMHGAIREEDIYEDEEEHHFADTDADTRGLDVDYGGQDRENSPGQQYLEQELYKLRIKPTGSQSVATHKTWELHRDDGGEYDEDADAQAAITESGLPEIPDGNTGGYTDRRGSPPLPPIPADTHVEMLPIDHGQVWQQNEYGSEPRMLPPWQRIHQRLLSWAIVWPMTELDNAVNSCSRGMQVDEIALSIWSTQTYKRYVRAKMTDSPPGRVDRLFVPPNMADAISTAVYNGRHGDACGMLRDLWAPFGLEGIPRLLIVLAKHRNDDNHWVVHRFSLPDGSLTTYDTYPERCLPDGRPLGWWFAIRIAWPDAIYPSPDHLMQKMVRLHRPMQLPIENSVAAAGIWRNLLMGSRAERSLDLERLRDLISTEVKNLRQRKIMGKLSIGAPRPNWEDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N5P6</accession>
    <name>A0A4Q9N5P6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative oxidoreductase C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_26246</name>
        <name evidence="4" type="ORF">BD311DRAFT_21975</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N5P6"/>
    <dbReference type="STRING" id="114155.A0A4Q9N5P6"/>
    <dbReference type="OMA" id="WKYDSGA"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052515">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013944">
        <property type="entry name" value="OxRdtase_put_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249:SF1">
        <property type="entry name" value="D-GLUCOSIDE 3-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43249">
        <property type="entry name" value="UDP-N-ACETYL-2-AMINO-2-DEOXY-D-GLUCURONATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08635">
        <property type="entry name" value="ox_reductase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidoreductase putative C-terminal" evidence="3">
        <location>
            <begin position="214"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU35939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="457" mass="50656" checksum="A0B85C1E447585C5" modified="2019-07-31" version="1">MSRRPSELGAPHFNRRPSVLDSPISRRQSGTSSRRPSIDPSRLIPMDKASHIGGTSDFNVVFVGAGNIMFGSDEGPWNHSFRFEHKLGPRLKVVALIDPAVERATAVLQKKCETFVRSAYENTRVFKTLEDFVRNMSPKDAPRAVIVGSPPMFRGTLQPGRDIETQIMKYFPGVAMFIEKPAATGPASELPEAFAVAKAINESGTLCSVGYMLRYLRAVQMMKQIIIENNLTVMATIARYACAYEAIAKPDWWDKSKSAGPVIEQGTHFCDLSRYFGGDVDMSTVNAHSLEWDENAGVLSKMTVDETKIPPENRIPRVTAATWKYESGAVGSFTHLVALQGHDYSCELEVYADGYQLKLVNPYVQPILYIRRPGSDLEESHRFPDDDPFFSEISVLIDNIEDIEEDPETATILSSFEDACKTYELTWAIRLSAERNRKAKLDADKAAATTAAVAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9Y8</accession>
    <name>A0A4Q9N9Y8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 17">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 17">2.7.8.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_836799</name>
        <name evidence="19" type="ORF">BD311DRAFT_783475</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
            <strain evidence="19">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a CDP-1,2-diacyl-sn-glycerol + myo-inositol = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11580"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.11" evidence="5 17"/>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9Y8"/>
    <dbReference type="STRING" id="114155.A0A4Q9N9Y8"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000003">
        <property type="entry name" value="CDP-diacylglycerol--inositol 3-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014387">
        <property type="entry name" value="CDP_diag_ino_3_P_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000848">
        <property type="entry name" value="CDP_diag_ino_3_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 17" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14 17" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="16 17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 17 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU35856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU65705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="267" mass="29717" checksum="6598AB8C24F2461A" modified="2019-07-31" version="1">MASNGNGSAALTRRRPSIDIVDAKVAVDLATAQTYSENVFLFVPNLIGYTRVILAALSLHYMSYHPKYCTVLYCISCLLDAVDGHAARALGQASKFGAVLDMVTDRCTTSCLLCYLTSAYPEWALAFQFLITLDFSSHYMHMNSSLITGSRSHKQVDGDVSRLLQRYYDPRTLFVVCAGNELFYISLYLMKWVHTPLSESFGITGDGFVAYLVSFTWPELIAYVTGPICALKNIVNLVQLWKASKVLVGVDLAERAKAREEQLLKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBT6</accession>
    <name>A0A4Q9NBT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Actin cytoskeleton-regulatory complex protein pan1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_941963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145304">
        <property type="protein sequence ID" value="TBU51590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9NBT6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035025">
        <property type="term" value="P:positive regulation of Rho protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051480">
        <property type="entry name" value="Endocytic_GEF_Adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006:SF6">
        <property type="entry name" value="INTERSECTIN-2 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46006">
        <property type="entry name" value="RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16652">
        <property type="entry name" value="PH_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0728">SH3 domain</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="378"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="493"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="834"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1353"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1521"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="124"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="493"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="630"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="712"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
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            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="770"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="796"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="853"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="912"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="941"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="980"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1030"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1051"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
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            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1406"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1452"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1521"/>
            <end position="1531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1943" mass="214320" checksum="DA12A747554C0770" modified="2019-07-31" version="1">MAQWGQGYQYPMQTGFNPQQQQQFQPLTAQPTGFPGQRPGFQQPQQTGFPQQGFQQPQQQGFQQPQQTGFPSQLQPQQTGFPGQLQPQQTGFPGGGFQQRAPPPPVPPVPPIPSQFQQQQPQQTSGFLSTQQPSQFLNTSPGLSALQSQPTGFGGLRPLVPQATGWVDPRLTMMTNTFLPANTSAPFNAAGLPQFQQQQSGFNLQQSFMQHNQAQRGNATPKVPWALSKAEKKQYDQIFRAWDTQGTGFINGQTALEVFGQSGLDRNDLAKIWALADVDNRGKLNLAEFHVAMGLIYRKLNGNEIPEVLPQELVPPSHRDLESSVDVLKDILKHDTRARSPAGLDPGPTSKMRERSFYNNATGAGGRQDATVYKYNDETPAGGFYQPRSRHVDRSAIRTTNESASPSADLDDMKRQLENTAKMLDRVADETAARTAEDDALEREMSDLKYRVKRVQEDLEYVSRGPRSVSKDDERRKLERELLELMHEKLPDLERRIKDREARKEREKREWARDRDRRNERFGRFDDRDSYSSRYRDDRDRDYDRPRSAYGDRDRERSRERDSYRDRDFDRDYDRDRPYSRNRERDRDYDRPRSPVVREPAPPAPPPPAASTPAPRAPPPAPSATPKKPMTAEERQALVQQKIRERMAALGVVAPSPSPSSQIDTSVEDRIEKERKEAEEKAKQAEREAEERERIRRERLEGEKALKEGKSPTSPSTTSAPPNPAAATPQVPTPKPTPPPATKAKPPAPPPPRKGPAPRPPAPRAAAAAPAPPPPAPAPPAVPPAPAAPVVDPEEEAIRAREEALRKQREERLARLKQLEREEEEARLAEQQYEARRRMLAEQSQQRSVASTPAPPPPAAPAPPPAPAPPPAPEPPAAVSPPAPPAPPFASPPVPSADKASHNPFSRMMKEGGPTSSPSPAASTSGSTNPFFKPQTAAAPAAPPAPPAPSKSPAPPAVKTSYNTAPADEDDDWDVIKEKDDDDSSDDEIDSSRDTRNKLAQQLFGNILPPSRPQSAAASGPSKHSEPSSPAVPAPPPPPPSAPPMTNHVPAAPPAPPAPVAPPAPPAPAAPPAPPAPGTPALAVPAPTGDRSALLNAIQAGRKLRKAQTVDKSGPPVSGRVLGDTAPPPHINPAAPVESTPSYEQPPPVHEPSQPENTRSSNRESVDWYAGLAAEGSAVQRFPSETLPTTVEEEEEPAAPAAVVPQIQIEGSDEGALADVDSSVEYRVRTLYAYEAQRPEELSFGENLILTAHPSKTGGDWWHGTVVRDGKSGFFPKTYVEQITPVIAHALYDYAGSNADELPFAEGDQLTIVDRSDADWWKAEQGGIVFIVPAAYLALADALVPTPIPQRLEASDARSSEEPPTATNSEPVREIEADDSDSDNEDSDEDDSSSDYMTASESESDESGKEGEQSEEAKRQERDARAAERQRVLEAAGLIIKEDDRRPPPRPARVRSRRRRPAPAIPERPSRSHLSPTKDLPPVPEADSRNPSLRLDDAYERYEAYRQSNLAMNRLSMASIESGTSASSPSAPSFPPLTPTASEQGEQRSHSSSFLHFFRSKTPGNDEAHARPVISAPILQREPSPSPEGDAAFGSSWASLVDRSALEEIPPGERRRQEAIFELIATEAAYVRDLQLIVEHFYTNVYSILDEKARTVVFANVEDILLMNTTFLSSLEERQKDCRLYIDRIGDILLTNVANLGVYMEYCVNQATAIKVLQSLRQSNQELAAALQRLRDDPTARNLDLSSYLLVPMQRITRYPLLFKQIIHYTEPGEDRSQVERAQQMAETVLEHINETIREQEGRERLRELSKDLWVGQGRLDLTAPTRYMGQRKLLKEGTLMKAKSGRKLRAFLCNDILVLTEETTKSLYRMPLSLAEVEVREVSGLIRDDLTFQLVMAYPRGGNTVALRASSARDCQIWMQVIQSACKRCREAQRRATRRSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBY5</accession>
    <name>A0A4Q9NBY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_864193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBY5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NBY5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="490"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="616" mass="64692" checksum="D9607A7B19DDE2BD" modified="2019-07-31" version="1">MQFPLNFLPPDVLATHPLSAFHPRNGHQVQGRKSPAVSAAPKAPGLHPLVYAQQLGWSGIRDDNALQARRQAAASPQVQAAYPQAQAAQVPFASAPPVPPLASTFQTYPFGGFPHRGSGPGSQVYQLPQQAANATMQQDLAVYQTQLLQAALERNLVIPYFVQTQAQTHTEAAAAAPPPPPPATATADAGPTMSVLDTKDPFVYVHPPPETLTTAQGRKLFKRLPKTRIRIEQACEACRKRKSKCTGERPTCKRCDRQEVECVYIAEHRANKWKRMQNRVPRPMDLDEGYDGDGTGVLSPCPPANSSRSSSSVSVSAYSSGTAVDSRAPPQGSGCGSADTLCAPSMFYVPPPLAGSSLPRPSSVGDVQASAQLPSGSFAGGNDAMAGPSSTLRSSVSSQTIASGTSLPPPTLCVTGASSPRSQQPLSNEPNGFLHPQQCRTRIPAPHSTPLATTTDHATRAGDVADVVERLLYLAKEQDLQCRNGPPPLGRGSSSSSSNASGARSGAQTPSDYFALPLPAGSDLPTGLHSKQAARDMLAVPGQAQMARSDSVATGFSQMALSSSSLSSCGASVADSLASGTSGQDWGDDYCSLEYEMYFHSSGLPDSVPSDVSFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NC67</accession>
    <name>A0A4Q9NC67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_339568</name>
        <name evidence="1" type="ORF">BD311DRAFT_554249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143476">
        <property type="protein sequence ID" value="TBU24602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NC67"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU24602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17175" checksum="D14BE99F6F985F66" modified="2019-07-31" version="1">MKGVLAHSSSLPTLGELQVFDKPLRVAVLRNLISETRTAETLEVICVSQQHNAVARRALLGPYPRCCWTSPHGPPHDKDLLRFWCPSPFGRCITELKILRCKTGRESSTTSHASMASTRSISKRISSSICTAKPSASCWYTFHAVSTICAPSKSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKD4</accession>
    <name>A0A4Q9NKD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1040077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKD4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025340">
        <property type="entry name" value="DUF4246"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049192">
        <property type="entry name" value="DUF4246_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049207">
        <property type="entry name" value="DUF4246_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33119">
        <property type="entry name" value="IFI3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14033">
        <property type="entry name" value="DUF4246"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21666">
        <property type="entry name" value="DUF4246_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4246" evidence="4">
        <location>
            <begin position="13"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="154"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4246" evidence="3">
        <location>
            <begin position="348"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="568"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="588" mass="67611" checksum="D6C0E524BD3396DD" modified="2019-07-31" version="1">MADSDSGHSDEETVNHVYSFPTPFEWNIRDPITLHELRMRAFAAMVLEKPRWWEKVLDEALVDKGRQEMQEFDRLAVARAQKQVKRRWPKDGDSDDPDDHSEDEDEEDSAIQQWLCDLVTDAQFEWTFAFLKHAAGQRDETTGCQVTTIPCGGLESVPDEEKDWHPGSDGQVLDLVHPSLYCLCIDRTQVVRPAEEIARFGDPLTVYNMAMCREERADIDHDIGDYYISLDFQWLSTDFQVSESGDVRRLGYMNNLHPIKHRALCDTITSVLQRFVPLFEKSLSDVLSPTPPLAINVNPYLWYSHLPLEVRYDSESEKRKPLIPDPTPFAPPSAEGRIELNLKGRVLQPHYRGGSWHVEGMANEKIVATGLYYYACDNITESRLAFRAQVGTDSESINMLYVNGDRRAWKTTYGMGSEEPLNQNLGSIVAAEGKCVVFPNIYQHRVQPFELADKTKPGHRKILCFFLVQPFVTIASTSRVPPQQREWILDEMERAPPLQRLPRELFDMVVDYALASTSTRKQAENDREELMEERKNFVVTHNEEVFEVPFNSCEHETYSYAVFTDQSGRGERRWDTPPQSLAHKQCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NL46</accession>
    <name>A0A4Q9NL46_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_823056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NL46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33875" checksum="4F12919F7B7FBD63" modified="2019-07-31" version="1" fragment="single">VLFLWDAILSTKDDVHFFWRKKPTGAAVLFWLNKYLAVVYFSYALASEIFELSAEVCALFDTMLLIPMTHVSIVFTGMRVHAIRRVWYLSVVTTLLCAVTVGLNLCRYGFGLTGQIMPPFGCVIQDSTPIHLINVTVTIASRGCQIVADLIAVVVAWLTLSRRYNSYDRSHWKGTLSGVLLLDGTIYFLALAVLNSLHLSFTLLSMEVFSLQNSSYFTAFTTPVSTVLVSRFIIHLQMANQRTVDMASSQAMTTSHASSVVFDRAIGSIGARITPDQYFGGGEESYDEGDGDSEHVMSQVPHVEGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPH4</accession>
    <name>A0A4Q9NPH4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_787043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPH4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NPH4"/>
    <dbReference type="OMA" id="KAKPYLH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="9094" checksum="C00584BCE28A9379" modified="2019-07-31" version="1" fragment="single">DDTPMDEEPLYVNAKQYYRILKRRVARARLEELHRLSKQRKPYLHESRHKHAMRRPRGPGGRFLTAEEIAAQKAQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTH3</accession>
    <name>A0A4Q9NTH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxal oxidase N-terminus-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_980293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF21">
        <property type="entry name" value="LOW QUALITY PROTEIN: ALDEHYDE OXIDASE GLOX-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043960806" evidence="3">
        <location>
            <begin position="22"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="655"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="4">
        <location>
            <begin position="213"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="5">
        <location>
            <begin position="492"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="723"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU54498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="788" mass="82625" checksum="7566DB95593B24CC" modified="2019-07-31" version="1">MLNRQLSLLALSLGAASTAVAQTHKAGSFEDGGHTQVSAMMMFLGNLNKVYILDKSEANAAKFGNYPAMGAVYDIASRQATTMSVTTNVFCASGMHLPNGSFATFGGNGAVGPGGNIGDVTPPGNPYTATFDTTFGDFDGTKSIRILDPCDDGDDFSSPNCQWFDNASLLSMQVQRWYSAAEPMGNGTIVLIGGFSNGGYINRNYPNVDPAFEGGAATPTYEFFPSNGQTPQTMNFMIKTSGLNAYAHTFLMPSGKMLVQANYSTMLWDPETNTETDLPDMPDQIVRVYPASGGVAMLPLTPENNYTPTVIFCGGSNMTDFQWGNYSWPFEDTWNVPASNKCHTITPEPTDGSVVEYVEDDDMIVGRTMGQFIALPDQTLLIVNGGANGTAGYSTRTLNTLNPPYGMSLAAAPVGQPAIYNPRAPKGSRWSNAGFDTSSIARLYHSSAILLPDASVLIAGSNPNVDVNTTTVFPTTYQAEVFYPSYFAATNRPTFTGAPKTLSYGGNSFDLTVPSSAYSGSANNAADNTTVVLVRGGWTTHAMNMGQRIMQLNNTYTVNSDGSITLHVAQLPPNPNLFQPGPAMLFVTVAGIPSNASWVTIGTGNIETQPTQAASVLPASSRLDGVSGSGAGNNNGNSSSSGNKANSASSSHTGALVGGIIAAIAAVGILGAVFGICMARRRRAAARQASSLSYPMSSAPGGAAGSRTAGGLGAGYRGSDSSAFVPLQGNESTTWGPGPNMHAAGASAVNLHTPNSPYFDDPRSNSTEFDPYHQNVPRMSADQRRGPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTP5</accession>
    <name>A0A4Q9NTP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CrcB-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_915066</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTP5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NTP5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="405" mass="43685" checksum="377F54297967E613" modified="2019-07-31" version="1">MSRAVNVPLASDNREEPFAEARNAEDGQAQSRQASTVEKVLSSGEPSQDNDSPPPRRSDVGNVLARHSSVRDADSLASIDRPPSEEENLPPSKIYEPLSFPVLALLMPASIFGVLARLGLQAITAYDGKEIFPLAWVQGAGCLVMGFALGLKEPIGQFYGPLYTAITTGFCGSLTTFSGWQVDIFESWINGTASHRDWLRDAIDGAGKTVFTFAISLSAISFGAHLSKLLLPYVRTARTPSRPVRYTLSALAVLVYAAAYPAYFRMSPRFRHEATAALLFSFPGTLSRYLLSLSLNPRLKLFPLGTFAANMVGTALLGTFQVLRSIRHPGPLSANACNVLQGLADGYCGCLTTVSTFAAEVDALPPRRAWLYAVLSWLTGQVLLAIILGPSIGVGHVSREITCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXH1</accession>
    <name>A0A4Q9NXH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_825623</name>
        <name evidence="7" type="ORF">BD311DRAFT_672866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143491">
        <property type="protein sequence ID" value="TBU23937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXH1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXH1"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="10"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU23937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17143" checksum="46B28CB1869F7F11" modified="2019-07-31" version="1">MLVLHPNSRCDVCLEGYYGPRDPIAITCGHILCQWCLQSLPKLQCPLCRHTYNPADARKLHVDKSAVPPCTPAISSHDLDTSQASRLQSSITRVTLEGASRPELEELLQDCHDWLDGQPQDQVRHLNVSSAVGEADVPAVQGSPCGPPPLVPQLPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXS6</accession>
    <name>A0A4Q9NXS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_769962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXS6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXS6"/>
    <dbReference type="OMA" id="ARERVCK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="26460" checksum="D05182865119C6CC" modified="2019-07-31" version="1" fragment="single">MSHPYFAPQSAVEQIKRHPKYYLNGGDVHFLVENYIYRVHRYFFERESAWFREKLGAPTPAGQTPKGSSDANPFPLDDVAADDFSKFLWVFYNPKYSIYDATLDDWIAILKLAYDWRFGEVKKLCTREIEKFIIQPVPKIELYQQYELDKKLLIPSFLYLCMRAEPLSLKEGRQIGLETALLIATARECARGKPAGNGARSPTAADLEEDELVSIIKEIFGLTAGPPSPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYK8</accession>
    <name>A0A4Q9NYK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_881020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYK8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NYK8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05238">
        <property type="entry name" value="Gne_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103:SF3">
        <property type="entry name" value="ADP-L-GLYCERO-D-MANNO-HEPTOSE-6-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43103">
        <property type="entry name" value="NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="336" mass="36262" checksum="581954FE0F72889E" modified="2019-07-31" version="1">MGKVILITGAGGFLGGKLASAIHEDPELTGFRLILVDVIEPRAPPHSNAITIKADLTDPAQADALFNTQYGVYDTVYCLHGIMSRGSEDNFDFGVKVNVDSVRAVLDAARHHGQKTGQLIKFIFTSSLAVYGGPLPDVIQSDTIATPQSAYGMGKLVDEIFINEYTRRGFVDGRILRLPTIVVRPGAPSAAASSFVSGIIREPLQGLESVCPIGDSLTSPELDLPLWLASPDVIIRNFLITRQISATRLLAHTRVVCLPGFTATVREEIAALEEVAGKEAVTLIKFEDDPTNRRVVSSWPSRFDNSYALSLGFIADSGGMVPIVRRFQQQLKAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5I6</accession>
    <name>A0A4Q9P5I6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PIN domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_867908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5I6"/>
    <dbReference type="OMA" id="RRGQDWP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18727">
        <property type="entry name" value="PIN_Swt1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052626">
        <property type="entry name" value="SWT1_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16161:SF0">
        <property type="entry name" value="TRANSCRIPTIONAL PROTEIN SWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="392" mass="44497" checksum="8BA91C8E03368F8B" modified="2019-07-31" version="1">MTTSTTAPPYDSTVEQLYHAANDVEMQDAFPTNKIYFYIVIDTNVLIDYCGIIEQFCFDVEKAGHPIMVVIPSVVLGELDGLKNRPELQWFARQATTWLLKKVKERTTVKLQSAKETLSPGARTESDEIRRNDLAIRDCCLYFADRSRGFGALLVTLDKNLNLECHKEDIDVCLPPQRSWSSRLLAKALPVAGVKVEIFQDREAFPRYRPSKTRQRLGHTEGPAALAPRLAIEDVDMMDVDDAAGPDASEEYVPLHARDSLHAQIAEHFTLVLRDLARRVHHECREPLTVSNSAHAPAYRRTALSSWTAAACFSYLETKKAFGREAWMPYFFARRGEHGWRKGQDWPPRMWNMALDMLEEVGRKFGDGALLSSVAAVRPHVQEVWEAKLRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7E9</accession>
    <name>A0A4Q9P7E9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1034571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7E9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="112" mass="13139" checksum="17638DFB7658107E" modified="2019-07-31" version="1">MLYQGYDETFREIRSRNEQDQLAHGSWTNLEEYSGSVLDRLYLLLGWVRRKELVYLRHVLDSAKPVELNPGRLRGLVRAFRTGNPCRSPPGWQLLPEKTCYTPGDISCIWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P977</accession>
    <name>A0A4Q9P977_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1008944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145373">
        <property type="protein sequence ID" value="TBU51169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P977"/>
    <dbReference type="STRING" id="114155.A0A4Q9P977"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="712" mass="80354" checksum="E752FBFD1F05D94D" modified="2019-07-31" version="1">MGQLSSSLNNTDQRIAKSFILTHKMTALGHAAQNATQRILNDDIILDNILPDLNLEDIVSVRQVSNQLRRCSNEPAVWKRVLTHTERQLPPVPPTERYSLANISQIEAERLLTRSLSLPKRWDQHRPQHFRRWEIEAQRKVLEMALLPGGHYLVATVADRNPMRYCIEVYTSDFNYSMGFPVARLTTPSKAFHLRAKYLSIHGRPGIAIAYIRRNYRRESFKDEFDINRLAPDSDWFSAKVKYECAVMHVPLQSLELLFDNDKPWDPKEYRTRALQQDRPFQVLTEITSRARMSNPIIDEDRNGIPLVAVLKHPDRIVYKNLDGGLGCTMYCAPHPSYQNFAHAIMAFTFVPSQHQFLLVRRAGEDPDPLQVAADLADLPPGEILTGPYYFAELYDVKYTIDGASLTCDAASRTAVHDAGWNFWHKVWITQPGMGAALKNDVSVRAELQPTSPTKPLPITIFVQADRSYGLVFSTFFPEPIPASSTSNADADPSTRYIYILSEDDPFIETEPLPEGMESLNDLYEHRILLGSTRPVIYTVPRQGSKARSFQVRMLGGVWDEGLLDKPPATVEAQAVGSQDVPANDAAHDEEVNDHDEEPEEDVDEGNEDNEEDADEGSEDNEEDGQSDVLEESSRIRVSHQFNLELADLDHVSAVAWDETIGRLCIGYANSTRIAVFDFAGAPIPARLWYDSFCFLLPGMSADTVHIFVFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA90</accession>
    <name>A0A4Q9PA90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_910714</name>
        <name evidence="8" type="ORF">BD311DRAFT_663933</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Secreted</location>
            <location evidence="1 7">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143424">
        <property type="protein sequence ID" value="TBU28171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145335">
        <property type="protein sequence ID" value="TBU51358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA90"/>
    <dbReference type="OrthoDB" id="4225815at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019778">
        <property type="entry name" value="Class_I_Hydrophobin_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00956">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041003638" description="Hydrophobin" evidence="7">
        <location>
            <begin position="20"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU28171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU51358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="9928" checksum="52C4DCB7E4102F85" modified="2019-07-31" version="1">MFSRLAVVSTLAFALLAAAGNCNTGPIQCCNSLENTDTAAASTLLDLLGVAVQGVTGQLGLGCSPISVVGAGSGSACTSQPVCCQNNNVGGLVSIGCLPVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB31</accession>
    <name>A0A4Q9PB31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_786414</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145368">
        <property type="protein sequence ID" value="TBU51185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB31"/>
    <dbReference type="STRING" id="114155.A0A4Q9PB31"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="537" mass="61633" checksum="7E7365CCC03BBFF7" modified="2019-07-31" version="1" fragment="single">MHWQYSGSVTKSAAELQRLVDDVLLDPRFEKDDLAGFSTAREKRRLDEHQTTLGAFSVDDGWREIEVELHVPKERVQHEDERTTESFFVRGIWARNFTEVIKAGVRDVVARKYHWIPHQLFRRRSADQPPERLYSEVYNSDAMLEEHQKLQEKPRNADDSPDVEYAVCALTVYSDSTHLAQFGTASLWPIHAFIANLSKYFRLKPTMFAAHHLAYIPPLPPALFEWYKELYGSPPSAAVIRLLKHDLMQKIWLSLLDAEFMHAFEHGILIECADGIIRRIFPRIFLYSADYPEKCLVACLKFLGKCACPECLIEKKDFGKMGTKTDLKYRITKRREDTGFLRTAIAKAREWIFRLGRAPDGSNIKASMLNKVSVTPTRSAFSIRFAKFQKNVYDLFTPDLMHEFELGVWKSTFTHLVRVLMAAGNDAVQQLDQRFSLIPTFGRGVIRSFGGNISAMKKLAARDFEQMLKVCQICAMPVFEGLLPEPYNSVILDLLFELSMWHAYAKLSLHTETSLCTLEAITVSLGKAMRAFVSRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCU3</accession>
    <name>A0A4Q9PCU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_919701</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCU3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCU3"/>
    <dbReference type="OMA" id="YEDEWTY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="379" mass="42951" checksum="FCDD6D02877DFC58" modified="2019-07-31" version="1">MSRLDPVQYAMHQPYEHTQDNDMDDDVYSVVSADSTGSMRFSSSSSSATSHDWEMRSASPAPSTYSMTSSLRAASYVHEFGRGINNYSEVYRLPADEEEFDRLDQQHIMFMEVMGRYAPPIPEILADDTPGVTKTCVDLGCGSGSWILDVARDFPHCSAVAVDLVPMQDVHMPPNCRSEVDDINLGLQHFYGAFNVAHARLVSSGIRDYRGLIDEMAQTLRPRGLLEVMEFDFRVYDEHRQPIMPTRLDEEMPAIARWMNLVHIAVEQRGGEPDAANQLNRWASAHPDLEDVVYREFWFQTCPWKPGSDPESGFDNHVGAMMRDDILAFIKSGRPLLLGSDLDVSIVDELELNAERELLEAKTRSYIRVQDVYARRKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDB2</accession>
    <name>A0A4Q9PDB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_833025</name>
        <name evidence="3" type="ORF">BD311DRAFT_674705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143516">
        <property type="protein sequence ID" value="TBU23075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145269">
        <property type="protein sequence ID" value="TBU52055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDB2"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU23075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10806" checksum="6BDCFD5B85D3655C" modified="2019-07-31" version="1">MTAHGELCRVLYAHSDAEVRHLSDEPQQYNDYEGFVFPDCTSGPYEEYPVLQGRVYDGTTPPGPDRVIYQTFIGEVCGKCCVTHTNAPTPNGFLQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDG9</accession>
    <name>A0A4Q9PDG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyridoxal phosphate-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_199936</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDG9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDG9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF2">
        <property type="entry name" value="AROMATIC AMINO ACID AMINOTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="6"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="40536" checksum="D2EB30E272F30450" modified="2019-07-31" version="1">MTLGNADAITKVFRMLGAPGDYFLADEFTFGPMPLAADAHGIKWVPVRIDSGGIIPEELERILSEWDIKRGRRPHVLYSTPCGQNPTGSTLNAERRKRIYELAQNFDFIIIEDDPYYFLQYDAPNTQSSVSESTKAFPTSFLSLDVDGRVIRIDSFSKVLAPGLRLGYITTAPQLVPHLINLIDFSTQNPSGFPQVLIAQLFGPTGWQLSGFDKWVRSLRLDYQRRRDHFLALFERDVQSTGFATADVPEAGMFFWVRVLVERHPRFQKIDPEPLPQSDALGRPKAVARTNAKALMDELFDACVAGGVLVCPASIFVLPTDGTFDSESIDDRSNFLRLTFAGSEETMSAGIPIFGKVLKQFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE02</accession>
    <name>A0A4Q9PE02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_860789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145224">
        <property type="protein sequence ID" value="TBU53114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE02"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="15"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9599" checksum="111F5E043D1DC476" modified="2019-07-31" version="1">MPGVRDKEGQPIEVGDTLETNFRGGKRTGKVEAVIENQHDVKERDDMLNVDVKNPPKVVYTNQHGHQVSHNPGTLSHVKEEEKATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEE3</accession>
    <name>A0A4Q9PEE3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_941894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145301">
        <property type="protein sequence ID" value="TBU51617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEE3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEE3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="133"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="578" mass="65487" checksum="84BD90FF047CEA0E" modified="2019-07-31" version="1">MYLWYGLSRICYAYLADVPSGEDPRAEDSAFRKSRWYSRGWTLQELIAPHRVIFLSKDWDTIGTKHTLVDVVEEITGIPCEALSHMKPLDEFSVAQRLSWASRRQTTRAEDQAYSLLGIFDINMPPLYGEGDRAFRRLQEEIVRRFPDQSLFAWEEVFVDLKPSQDLAQCSSLRGDTVIRLDYRSGHVLFAWDPSSLINGGGIRAVSHDDVFRRLQLSQLPAPQYTFTPHGIQTHLPVVLIDHCLPHSTITYPNYDTESRWYLAILGCEHTDDPGALLGRVCYISPSHSGVEYLYCEHANIDPEPSRGPQLADLFPLSPATIERVRKHIQLKTVYVSHPGRAGIRTDDSWTEPHDTIILVLPKKNRDDLRARGYRAELRRPDEYQRTATHRLTLFDDDHTITVEYQHTLEDDGRGLIIEAHVKMSRPLRDSHGEIEAAPNSVRWQDRKPWCSSLDAEEVVFALATKKLVVKLGFDWAEPSCYFIYADIVTDPLATSPQRVHEEGLQGPEADCGTGVLNAVVEDDGGGDDIPRVDDDTRPETLDSVDSAILRELRDEGEEREASLEKSVEGPGDEGDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEH3</accession>
    <name>A0A4Q9PEH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_982409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145296">
        <property type="protein sequence ID" value="TBU51647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="21252" checksum="14C0236801A65138" modified="2019-07-31" version="1">MSTVPRQTLTIPDEMIPYLSDHLNLDNVIRCPVIVRKDSHHLHFHTPWIRVPETHPFGPIPPPDTPCWLILPSKLEPGWTLPKNVHFLGRVLRVAEYQESRVIVLVQHIQSPAILSLAVPYEYFVGDTSFWWAQVVWNVVSRVKILRKPDNEDYLPGELHCVSLDPITNDWEINDEVQATYSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFB6</accession>
    <name>A0A4Q9PFB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145209">
        <property type="protein sequence ID" value="TBU53629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFB6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="812"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="837"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="868"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="918"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="971"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1008"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1075"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1152" mass="120762" checksum="4C797AC8718B3789" modified="2019-07-31" version="1">MATTTQILSNSPALHSLKRDQLVRLCKIHHIKANGKNSELIERLKQRALELPPEELNQSEDVTPEEDDRMEDVQDIPGGMPVDAEPAPVPDTATNGDDYDMQDVVLTSRFSIPRPSEQWEVVMEDIEELDETMGTASSKNSLRTVSNREFGTHMSKSSVSSSIKALATSLGIKRVASKASHHTHTTDSANNTINSPSKMPSFSPGKLLGVGGGNSTRARDSLAEHAIPYDHIPPSDSLPETDHFKFSTPDSSILGLDADADDGDNDNDSDANGDAKSTARSSVRLGPAGVRSTIRLVSHPAAVKSARGDDYAFSYNMSPPKLPVVKTDFDIVAGTPGTVRTLNVWPATPRSVAPSVEGEGRLYPKLPLDEDGGEGMPGGMHVAAATPAKPIMTSTSQGKGTSTPGPVDQPDMFSPSKRTTSPVADDSAAPTPARGTSVPRSAPFLFGSPLPRRPSPVKKGKETAKGENGEATAAAGVSNAAFDGIAKSVLEEMHRRLAEANKDKPASSSNQTAQPLFTLTSTTAEMQDRFAKVHEAEFSKMDSIATHYAARRPAKRKSDALGRGASGRPSAGQKRRSSAAGARVISAGARRNKNKIAVPGGFGADDEDDEEQEDEDGKEEGEGEGEEEDDAGARRSSKRMRITEGWDVHRAGQRVSLAPPLPPAEEERKMREREAVKRELNAAKARRRSSRGRPSIGAPQAKAKSRFGFLGAAKSLVRNVWNMGGGSKAKAAPANPPPSSIPVPKASQTPAVATADKKGENGKANAAHMPSKVPGTSSVAFATNARKASGSQANKLLKPPPPATDAKNSATITSTKSGSSRSRSPIPSFNVTVPSGTIRSTATAASRPSSIAGTARSRVSDTNAGNGTATSRQTARTSTVSSMGTRTSVTSGSTAVSSMGTRRSFASTNTLASTSSKADAKSPEMKDQPSLRKRTSSLLAPTASSLAKTIGRTSGLPSVAEAQKEKPKRTSVAQVSSSSKAAITSPQSHSPSSPRPTRIFSQPLTNFASSPAPSVSPASPVYHPSLTSAAAAIMGDAVSSPSKIPRPAVIPPKPKQLVARKPRISRSKVIAKLGAQRAAAAQGSSLGSPSAKGARTRSSMGARRSFGGVKPGRASAGSEIMRSAVKKRARQSEYIRRKSRVTSENDSVAGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGS5</accession>
    <name>A0A4Q9PGS5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_832179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145251">
        <property type="protein sequence ID" value="TBU52421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGS5"/>
    <dbReference type="OMA" id="QFYEVIA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="244" mass="27705" checksum="90C0ED4EE3A2306A" modified="2019-07-31" version="1">MAWSPNTWKTRFSLNIKGLPYKTVWVEYPDIEPLCKTIGATAAEKRRDGTPLYTLPVIHDPNTSAVLSDSAAIAQYLDKTYPDTPTLIPPHLDALTAAFEDAFWSVFEPGYGYIICAAMYDVLREGSRPFFRQTRDKVLGKPGEIEPGSEKRAQHWEKNRVGIHNIAKWLEMDGKDKLFFAGNDAGITYADITVAGFFMWFKKCCGEDSQEWADIRAWDGGRWKRFMEAFESFEVVDVGEELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGW1</accession>
    <name>A0A4Q9PGW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_228589</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML145248">
        <property type="protein sequence ID" value="TBU52501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGW1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGW1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="39"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="346"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="836"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="565"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU52501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="875" mass="98424" checksum="FD719ACB13E67C15" modified="2019-07-31" version="1">MAPSAAPTPSAPSTSKRTANSTSDRPDRQRVEDMEVKPYVIVSDLGKGSFATVYRGYHEQTHHQVAIKTVNRSGLSPKLFDNLQGEIEILKSLSHRHITRLLDVIRAERNIYLIMEFCAGGDLANYIKRRGRVEGLEYIPSPGAAPTYYPHPKSGGLDEIVLRSFLRQLARAIKFLRQRNLIHRDIKPQNLLLNPAGPDEYSRGHPLGVPVLKVADFGFARFLPQAMMAETLCGSPLYMAPEILSYQKYDSKADLWSVGAVLYEMAVGKPPFRAQNHIELLKKIDNSKGIKFPDEDPAMHQRAQARGEELKIVPPDIKILIRSLLKRVPAERSSFEEFFTSTAMVKSKFPRPREPTPPPPDEYDEDPDRVPEHYKRIPPEVLDPKAMIPPAKIKFRRRSSQGVPEGALQDGFADNVAGPSRSPPAYSPQFSPVPKTKPLSPDTSLIPGETEEDGALRREYVLVGDRQAVEINRAVDEITSRRKPLRDRKPSPLPEEAVSPAVETSPYDLTSPANANTTFPPPPNVNLPPLSSSPSSAVARANGNALTRAISMATGILRGSRRRPSSYQHDYTPSSPRRLQTFGGARGQGLGLELQGVREAEEDELLTSLEELAQKTEVLTHWADEMYDYVKAFPQKPLPDPTKFSRREGETERLAARRKNADIQAEYNAMTCVALYMLLMSFSQKGIDKLRNYHEHLQMRDPDGELEVSEGFDEALSWFKEHFIKCHDRAALVKTWLPAQYTGPPTFLDQLVYDRALLLSRTAARKELLDQATSPDECEKLYEESLWCLYALRDDLLQADNPFLNEDRNTISTWIKRTKLRLVRCRARMGMTDRERVKDAKRDDNLTDVPRIPAPWDVADAAGEMPPQGPDIRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHR0</accession>
    <name>A0A4Q9PHR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_981788</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145247">
        <property type="protein sequence ID" value="TBU52516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHR0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHR0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="23109" checksum="5EC6431F0327979D" modified="2019-07-31" version="1">MSVGTGCSFNTNFTHCILTLPLWMPSQVLIGAVGYHSKANYGEFVTLFSLFEPEKSSNGCVKNIPSLYGYGRMSQGSQHQDKRNVAQRGMDLIQSWLGPRNCAGEATYSRRYSSPLRSGHKAANRFTESTVYRYMEDPVTSKKWFKANTDNVLVIYEAEHRITKEDLYLVIGTLKAQDYALFISHEHPNGQVNFNVFSAMRNGCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK24</accession>
    <name>A0A4Q9PK24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RNA polymerase II-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_935823</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RPAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PK24"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013930">
        <property type="entry name" value="RPAP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057989">
        <property type="entry name" value="TPR_RPAP1/MINIYO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08621">
        <property type="entry name" value="RPAP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25766">
        <property type="entry name" value="TPR_RPAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RPAP1 N-terminal" evidence="7">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="6">
        <location>
            <begin position="329"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1/MINIYO-like TPR repeats" evidence="8">
        <location>
            <begin position="1111"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU54461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1303" mass="143490" checksum="F0F32B14F46F7D63" modified="2019-07-31" version="1">MAHSPLIGSILERKPFSKPSAPSEATTKTGFPAVQHRSQRAFARARGQPQKRARDVPVVQSSNVVPPPRPVSTSPFEENDWRVQIEEENRRRVEAMTEEEREQEKVEIFEKFGPSIAEVLRRAREARESKQKKSEGEKVGTEPSSSNTPASAKTGGEEAGTSLSPPSSPSRPRSERTRSLTSVLRSSSPSPTSSSSTRPPSRSGRKIRFADVTPSDIHVYESAPPSPRKKALALPPPSASDDQVVSLGTWKPPAQFRSPVVPLAASLEAESEASQEVAGKVGALEEGTPEDIRRRFFPTAPANDPSLEWMRGTGTAEREPETESSTPTIRFDLTGTPIPAHLSNSLPTHLGLHHHAEGSHAGYTLEDIFLLSRSTVPAQRASMLGVLAKIAHKLARTSVDKKKGIPELVGQEIALRKRLLAAGAEAIGERASVGARAVELLWECTSQWDEDLKSVDGVETKDLDRGEALSSLPLDYLLPQIANALSVAELPHESLLQLLAVLHRLAQHSNSIATEIVKTKNLIPSIFQRFLLTPIPPTDDSPFPNPLALKFLCLLAASSRENASALVDPADSLLRFVITLPTSSPYPLPLATQLLSETLIFYATLASYGFYAHVTTTAQEYFLQISKYIRSADCQSSQLRGAWLRALEAWTVCARDPHRTTPSHEVLWSQVVGWGWAEDMLELRIQLNTSDEETWARLWSALAAFLEGAKVNGVRGGEEERALVLGALKDDFAFGTQKQVVELALKWAREALGKLSAGMRQGILASDVPSLRDVDRHAGTLASAMRLFLSCFSESPGDTLIAPPFNLPFGDLSSVCAVITTHPLWTSLYTPQSIPYGHLLCRPLSTLLASYLQLSRKIPGTSPDLWMAQGFAILCRLFPGDEAVGERTVADIAETITADFLRARGWSVPEDIWEKGGMDVIVPFLTQSLRAKGEQVIGPAWSTPQSIATATTQRLPPLSSLQPNDQRDYPLPLTKDWMFCPLDHLLKSGESEVFKNLPDSWNASEAEVVRATLLFVRVSQEVLRYHRLNDFLMSREEVAFGCMKVFMLEHGQQQDDSAEEVFRDTIVGRLMTELLAPFSASASAKTLKTPPPSIHTSDSIDVVAKRFLGNAVPFYQWYTDFVGLYDAISFAHPLFARLLLSPLSMRYPADYRKYLWADFNHVLRTIRTAPEDVVTGSIAEYLWPVETDAEVVGAYLRALVKGSLEGFVRLVAVHHIACNIWPDLGSVGEERTKKLLKAVLVQGGLEAIRDVVLYRQNREGTVVLPPACFEQPGKWRAQRLDFAGKSGEDVRERLTNLLEGKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKE2</accession>
    <name>A0A4Q9PKE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_951290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145184">
        <property type="protein sequence ID" value="TBU54613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKE2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKE2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="528" mass="58499" checksum="066F729AF68440BA" modified="2019-07-31" version="1">MFIYNGKFTYYRYALDETITFVFPVGFALNDPVNAYWQWTVDAKGNQKPNTPRSGIISSVVKTADEYRVHVSFGYYRVDVTVAADFKSISFLMRSRSEGPAGPFTLPAMHAEASRMPSTVVYTGKLNWRSWAENEMITLVIPDGVFEGAFFGLYHQWTVDAAGNQKTNYPVNGVFQNVSADLSGAVTATSKASYYTYDFSFHGKEGSFTLLDPNGDKSEGNKIMQTDFRSLGTKKALIVRYGTGTDDGIFYIEEMLTKHLGFATDDVELLYYDVEPSNGAKQCTKGQKAPTVGNFETSFADLVSGAEAGDVRFVYIDAHGTTYPGENDRFKPADGKDYGWVLAAAEDGVQEGLVDGDWFTSTIRSHLKSEVNLTILASSSGGAQLGTYTKTPGILLSGCHETQFNIKAVKRPEGLHDPWAFAVAAVIKDRVANKRSVPAYSVLFNEAKRYIKKQLDQGLLNPYYKGFSPDELQPVPPELLWNTSHQDPQLVFDSGYVNPDQERFLFPFVAPGEAKVSGQVTRYPQDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKG2</accession>
    <name>A0A4Q9PKG2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_935620</name>
        <name evidence="18" type="ORF">BD311DRAFT_696370</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
            <strain evidence="18">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="ML143430">
        <property type="protein sequence ID" value="TBU27659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKG2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKG2"/>
    <dbReference type="OMA" id="CSWVVNQ"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU27659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU54611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="360" mass="41200" checksum="4AE9593073418B0F" modified="2019-07-31" version="1">MADAKAQKRQKFESVFPILRDELLAYLKQEGMPEDAITWYQRNLDYNVPGGKLNRGISVVDSVEILKGRKLTDDEYFKAALLGWGVELLQAFFLVSDDMMDQSVTRRSQPCWFRVEGVNLIAINDSFMLEGAIYYLLKKHFRSEPYYVHILEAFHDTTFQTEIGQLIDLITAPEDHVDLSKFSLAKHQKIVIYKTAYYSFYLPVALAMYMSGIPHSSTNDPYELAQKILVPLGEYFQVQDDFLDFATPPEVLGKVGTDIIDNKCSWCINVALALATPAQRKILDDNYGLKDKAAEARVKALYEELGIRQKYAEYEEGAYKRIIGLIETIPPEGAEVGAGDVRLRREVFKVFLDKIYKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLF0</accession>
    <name>A0A4Q9PLF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_926958</name>
        <name evidence="3" type="ORF">BD310DRAFT_930759</name>
        <name evidence="2" type="ORF">BD310DRAFT_934673</name>
        <name evidence="1" type="ORF">BD310DRAFT_935925</name>
    </gene>
    <organism evidence="2 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145189">
        <property type="protein sequence ID" value="TBU54421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56785.1"/>
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    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6446" checksum="7011AF7DF6FCC2A8" modified="2019-07-31" version="1">MIMYMRLHLYYGTSCLDQGTGSPGGQWALKYRHGSTARISILQNIVDLPGYACGQPTGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PME7</accession>
    <name>A0A4Q9PME7_9APHY</name>
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            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
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        <name evidence="3" type="ORF">BD310DRAFT_933785</name>
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        <name type="scientific">Dichomitus squalens</name>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <begin position="22"/>
            <end position="44"/>
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            <end position="75"/>
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    </feature>
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        </location>
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            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
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        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
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            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
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            <begin position="173"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37652" checksum="BF536F1CCBA099B6" modified="2019-07-31" version="1">MSSSPPSNMTQPSMDLLAGPQIIGFLLAWGLQGALTVQVYLYHLSFPEDSRAVKTLVYLVLIYEWVQTGLVTSAATDVYVYSFGSVASVLDYHNTWFSVPIMSAVISFVVQCYFCWRIWTFSRLKVVTGVALFLSFSQMVLGVAGGITLHIIKAGAVGDTINRPIVAAGLFTAVVADVIIAASMTVLLLRSRSGIKRSDDVILRLVRLGIETGAMTATVTLVYALLFVVYTDNLLFECPGLILPKLYSNTLLVSLNNRAYVRRPGGQGDVHTFSGRTLVRDGRADISPEHSSTSQCEPHLLTPRMQIGVAAETYVSRDVDLKMAASNKEDHMELNPIAKGGVVPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN80</accession>
    <name>A0A4Q9PN80_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_969097</name>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU55666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <location>
            <begin position="101"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15499" checksum="AC35B28A5909A5A2" modified="2019-07-31" version="1">MTFDLTRNNAGCCRIGRSYGLETMLADFEALDGPEPLLLIPQGTLFGQIMFISTLALSWGYNSYLSSVDREDIQTDILIESVLRLTLDERARKYDFKSRTGILATPGPHEDPERVAPKRHEDVEAVETGRGSEVDGGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPA3</accession>
    <name>A0A4Q9PPA3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pheromone A receptor-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_931983</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU56143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPA3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
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        </location>
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            <end position="187"/>
        </location>
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        </location>
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        </location>
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        </location>
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        </location>
    </feature>
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        <location>
            <begin position="388"/>
            <end position="401"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="415" mass="46553" checksum="D4BFD35F900BBFBA" modified="2019-07-31" version="1">MLSRSDPTYPAFPLLAFLGAIVVLIPLPWHFQAWNAGTCLFMIWTALACVNLGINSIVWNNNVINSAPVWCDISSRIIVAVAVAVPAASLCIQRRLYNIASVKTVNMTRAEKRRGIIIDLAIGGGVPVLQIVFQYIVSGHRFDIYEGIGCYVYTYNTPLAYPFSFLWPLVIAMISGCYCVLTLINFFRRRAQFNAYLTSNSSLTANRYFRLMAIASLEIVCTIPISAYGLYLNLTSGTMNPWISWEDTHFNYSKVNQFPAVIWRADTTAVISFELSRWLAPFCAFVFFAFFGFAQEARIHYRKAFLWIRSLPPFRGLFPERPLKGGVKLPNGVLEKADRRQPKHDAESLPVYSARPPRPPTFSSLSSSLAPEEMSTLSAAPYHEKIPDTPSTPSTASTASDLSYDDRALYEHHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ25</accession>
    <name>A0A4Q9PQ25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_612985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ25"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="113" mass="13250" checksum="D40790811775B920" modified="2019-07-31" version="1">MRLLVYILLPLLAFFFIARLTDVSLFLRLSSFDLRLVSYIIPFSSVSPVYPLSLGLLHRPFYHVPIPLTLCIYNAFLDVATLLVHCWHTWRTLLFRFAVCFQSFRDDHAIKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRG1</accession>
    <name>A0A4Q9PRG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1040148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRG1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="186"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="343"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="750"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="775" mass="88838" checksum="3C5F8B3D98C21A5C" modified="2019-07-31" version="1">MEESVSDVESTPLNPRKADSLKHNIDEPDLEEFRAKNEEEMRAHYVGTGSVEEFLDGLLPYRPRTNKRPPLPDNPFATLKEADSWVEAKVVDKFNEALKTHSLCPKLAFRRSQHRPHPKNTDETGQKIDGGFFRLSEAPDDGRPHWELQLVQAEFKGRKDKDKYDPFADGETPLFEPIAEVIEPSAETRTEVRGQIITYAEQVFAMQHRTFVFMLLVMGRRFRLIRWDRSGAIVTRAVDYYESPGPLCEFLWRISHVKPVALGLDPSATRLTPNSVEFETMTNIAKDTSRDLPYHAPRIIPPDYKLPEGYWFKYVREMFAESISNPEWLRYRLEVVCNGEIRSFLVGRPCFRARALAGRGTRGYVAYDVKGDRFVWLKDCWRASYDLLEKEGDILQRIRNECGADVSVPTVVCHGDVPLQATLTADWWEHKHPLSPDDGRPLPPSGPPPRRSSRITVPMKRKIPDDENEESNDEPAPNFRPDCPLRHHEHYRLVVEQVCMPLKNFLNGKQLVSITSDCVLTHGQVFEKLNILHRDISDSNILIHPKVIEGDGGLLIVWKGILADWEISKPVSTDVRIIARQPERTGTWHFLSINLINNTWKLVTVADELESLIYVLIYYAVRYLRSSLVSREDVARFLDDTYDAYSIQRGELFCGERKVRMVTNGTLSVYNARNASYDPIVFNSPMDKLINPILKGFRARYNVMQAQSLPTRRPPLATVRMANKVNSHKWIKGYLELCYGDSGWSGLQDKAGDRVPSGWESNRKPIPTRFGGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRG2</accession>
    <name>A0A4Q9PRG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRG2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="253" mass="26874" checksum="75DDA36E513475F2" modified="2019-07-31" version="1">MPPVAPGYSDNTHGGTSARSPLARRGGAAGENAGISVMESNRTRSVGGANQTVPSNVFAVPRPPRLNPYHDPASVYGQQTMYFSQRGFLDVAASDATGLGASGATSGYSQDGGNVGPSAQEHHPPSTIWIESRTQPPLASAVPATPAPSDYTDSMSISSSTIPPSYHTHYSNPGLPSYPAAPPSSNYGSMQEPRAPPSAFRVNRARLRIPHSRTPYWISQTIPTLPGSRWRRSSSRWGFGQSQSRRTRVGLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRZ7</accession>
    <name>A0A4Q9PRZ7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_821994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRZ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="62"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="251" mass="28202" checksum="EFD9F051561860FB" modified="2019-07-31" version="1">MSPYYLNLSTPNIQFIQAFTSWMPAVRYPDSEHSGFTSAQSEFIVRICASVSLGDAKGLPLVAILYYDYALTIVAEVERFWMRRWSLVSLIFFLNRYLSLLGHIPVAYELFGVYDASQALIAAIQIIIGVLQLFRTYALYNRNRRMLFFLFAYGLVAASIAIWVVTKAFGISKADPQDAVSTSGCEGFLLEAEGRFLAGAWSISLAFDAVIFMLTLYKTLDAVFRSATRSSLSTLLLRDVSKFMFDSKTQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT46</accession>
    <name>A0A4Q9PT46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT46"/>
    <dbReference type="STRING" id="114155.A0A4Q9PT46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="480"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="689" mass="77705" checksum="BBC87AB9903FE399" modified="2019-07-31" version="1">MKLDIPRYISDIVAQFHRPPRILAYCSINMPPIKCVDHYWNADDKAWTHKDTDSKVPAEAVQPQTSSAGSSDDWKEFCFVVVRKLPGGPVTRRNNQNQDQSITFKIVVKSPHLHKACKEVIGEIPGLSWNAEPVELDPHLLVAFFPKLEAHHAALESITRSDDEEQAYTTLGALLAWLRQNYRTTLHKLANLTAHGEVTYELLYGILVPGTILITRNGATGEPRAVRLLTHTHNDERYALNCEGIEAADPQKDTSRDDESDDGYEDQEQSSPLQDKSRAFGTYNITIYVRAFGGTHKINRLSVYPIQHHADPAGLRASLIKRGRKWASLNGVYHVHYRGLAGRHVGDSYIRYNVTSRIMADRGNFVRLQPNYAVPKPNTEQIVSQLPLENGTVWTHEVEKSDFGLTDDQLLLATPILYGFSLADKFWLEFNVQLVTPITWNPETFEALVLPSDRKTLLRSLIESHDSDSNFDDFVRGKGQGLVINLFGPPGVGKTLSAEATSEHIRRPLYVVGSGDLGISPSDLDNTLERIFDVATCWNAIVLIDEADVFLEQRSLHDMQRNAMVAVFLRHIEYYRGILFLTTNRITTFDEAFLSRIHVALHFNELTTPTKAQIWRTFLKKAGIADEEVSEDMLGKLADREINGRQIKNACRTATSLARSRKQQLSYAHLHEALNAMEEFVAEFAGMRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTF2</accession>
    <name>A0A4Q9PTF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_928670</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTF2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTF2"/>
    <dbReference type="OMA" id="GTIYHPG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="16">
        <location>
            <begin position="18"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU57767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="23963" checksum="6328806F83311790" modified="2019-07-31" version="1">MFKSVVALVTLAASAAAHYTFPSLVVDGTTTPAWVNVRKTNNFNTQAPVTDVTSADFRCYDSQTDPTAETITVQAGQPLGIMSDGTIYHPGVVNVYMAKAPGDVSSFAGDGDVWFKVYQISAVTDGGQSITFPAEGVPGVTFTLPEALPSGQYLVRMEAIALHVASTYGGAQFYISCGQVNVENGGSGTPGPLVAIPGVYTGYEPGILININYPIPKNYTQPGPAVWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTS8</accession>
    <name>A0A4Q9PTS8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTS8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="71592" checksum="D0C1E8005044BC2C" modified="2019-07-31" version="1">MPKRERDIYLRLHRDPKGAILKRDKAPFGLRTPNGFVWGHRLDHIFWMPRVPGTNALTVWSRSMLKAFGEGYNDGDWEETLVPPRVLRPWPVLKLEPQNGDADANPDTTFNAVDQGCDHEHKGLKKAEEEENEAAQVEEAKQSLSFMALMGECPYDPYETCTGPVLFNAKGVKDAEGTPYSYVWCEHFKTLLLGLPDPQSVVVFAVATTGNPCLDADTTGVRVIGADRSAEAFKGKGKESATAENDGTSTDDLPSASSAVDVVMAESETTGIDAVAATEEVSSTGDPGVTASNEKSPAAPHDPYSPEGLPKLEEFIPDKFFPDVLLVHDPDNATKSRKDDNSEGDLDKPVMYKRYFPSPEEPKGNGEEETAESEATPSPKENVAHLYLRKKNRFGSGNHSFVYRAPLTLPPPLSGRSPTGQVTVAAKLAYSRCTAHELLHNEARVYDTLPKHLQEDWCGYNVVPQCRFPVPVSAITPKFFGFYLPVDKEGKFMMKRHAGCSEDEPHAIEWASPILLMEECGTPVEPAEFTADQRTECFSLILRLHHMDIVQGSFYIRNIMCQPGPLTLPPDKRSYDHPSFRIIDFGRGKCWDWELEALTGAKNMSDKSKAEARDRRRLEFRRRISDEVARARKELLVMDFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUX3</accession>
    <name>A0A4Q9PUX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_967703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUX3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54658" checksum="38C9192BE2F3E854" modified="2019-07-31" version="1">MSSLSESSDIRSGLDTPSTPASTPPAVFSRSMMKPSTEHGLPTPPKTPSKKRPHLSAPETPTPPQKRIKSEPCDSDFHVVEEQMSAIFWYSDGDVVVRAGDILYKLYQSRLVKHSVYFANLFSDENAKMPQVTLEGVRVYHAPAELLVEDFERLLSELEEPSSKITRYDAIRLLRASTILACDSVAAVAKRHILALWDSSAPPSPRSRAPHLSPDPPEEDRPSYHLCVYMLSFAREHNLHQILKRVYYELISNPKFWTALPPLPAPAPCPSRSSPSTSTPRNSPSSSTEDDKLRVRERLTGLQTDDRIRLLEGRHAFTHVWYEHVRTPPSTDPDTGKSACPCPRSSSPTETNIEKGGGGGNRHRMQTRTKAAAAEKRDSGNARGQREETGKGALDDDFIPNACDALSVPRGTYYREAKWAHFVNHEGTSAVEDGAMDPIRYDLIARKRKQLALTWCTLCLRKWREEWEARRWEWWERLDGWLGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVH1</accession>
    <name>A0A4Q9PVH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_819382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVH1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6505" checksum="37AD05CAB1C89220" modified="2019-07-31" version="1" fragment="single">GTADVTTHKLYILDLGREGSLASTLDGGRELLTYVHIRRHFDGSLGAILAVSMEAVLEHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW00</accession>
    <name>A0A4Q9PW00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_443672</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. ROCO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PW00"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="1759"/>
            <end position="1982"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="2163"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="2215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU58822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2301" mass="256237" checksum="A834D28E333889C6" modified="2019-07-31" version="1">MRRKYAQPALPTLYFRDGILSVPGYTFEKAVPWEDTGSMTLLAEGTNLQDGTSVLAKIVPAHSNASMLLEREAHILEKMAAYPESSSTTLRMIDFFTIPKTNGDCVVLLLFHPGLNILGRYFPPAKVNSLLLGDISRARPASTHRDIYMSGVEEPYIMEEMEAIEIMDLATFLEFAIQATHCLEMMHRHGLIHREVRANAFHLNHHSGLVRVVHFGNRAVSLEQFGVPSEFVLKADAFEEVQKLKVKEALCYFAPEQTGSMENLAEDHRTDLYSLGIMFWTLLVGRGTMPFEGGPLELLHAVVQKRPMPVHEVRRDIPQVLAMIIEKLLSKSPDARYQSAYGLKQDLLECQRRLLAAVALSSDEPAELIPYFDIAMQDRCLEFTMPSPLFGRDKELETIRNIIRHTSTSYSRQLATSRGSFVVSSNGSTGSPEDPSDSQSSKSEASGHMNMSPDSPQSKVSSIELPGAPGSGTVTSGSTIPTSDGLRRVALAPSQGRARTHAAIIVGPAGAGKSSLILAQQAKWRSHGLWGQAKFSEVEPGPFASLLACLSHVLRQLIVFHSDLHRFVTDLKRRLGPQMQNVPLLYEGAPELKTIFSLFNISIEPTQEASEAHELPARFQSLVETVFSVLSETRLLALFLDDLHEAPDSSLELISALVNSRTRLLIFGTVRSDKPEKFDRIRHTFSTKSTTWINLEPLGYPAVSTLIARTLHRSKEDVSHLARIVHSSSEGNPFSARNILTTLHRQSLIWYDWDKNNWQFDIGKIEKTLFDKKFKSAAPGDLNFLISHLRELPEDARKFVIWASFFGPTFKVAEVALLMDWDDSGESSGSSTEDEQRGDLWNVTKAVKEIKEREKETSSTRRSIRGLQTAITEGWLIQRARDMCSFSHDRYRQAAQVEAEAQSEEVIAKMSFRIILMMLHDATPDIYRITEHAKRCLPLLREYSKRDELLEMSIEAGDSARARGAHELALQSYMNARSLLDDDPWKTDPVRTSSLYMRLAELYTWKAEFTLSDNLIQECLQHCEQPEEKARLLRLRSRNHWMRGNYTAALNDNTLGLHLLGVEVNAAPTRREADIMFEQVKNEILAVGFDDILAIPRARDSRTDLAIALLNDAGTNAYWSKGEGFADIIGLTTIQLALRAGMCPGTALGFFWALGERRELFRFSADLGKLALRIADTYGTNFEKCRALLLFSIMVSGFDNVHIRANVPRLEQAIKFGQSAGDRIYTGFATAHLIVTRLYICDHLSELVIGAEEAVSDITLWTPSGDMSILAQGTLNCIRAIGGYTVAGAPETAFDTEGFTEAEYLVQLESVEQLRTAMNWYNSFKLVGLYCLGFVEEAAKLGFNVYETRDTNPNHRHTRYSLFFHCLALIDCVRRGTVTPEERTRYIKQIETNQSYIRKWLSPSPVNTSTWVALVDAEMASLTNNPDAFKLYDVAVKLAVNNDWLLEGGLGLFLQGSHFVRCGVEGLGSELQRRGIARQAQWGARGLVTYLSSLLETRAQPVPLKRHIFSADVAVQTDSVVISAQPTLQGPFERTSLDASEEEQISTLTAADLASILKWSKEISGDINLSMALQRLTEIATEISVSQSTCVVIAREAGDYTVATSMNPPEACKVHENPMPIRSISDPLRRMIIQHALNSKERVYYEDIASEPRFATEAQQSPHRSVICIPIFSNRGQTFGVVYLASKYAFAPNVVTMLTLLCQQASVGISNALLFRSVQAGTKENLKMISAQRDALEAARKSREDALKATKIKSNFLASMSHELRTPFSSFYGLLDILSGTELNAGQREIVQTAKQSCELLLKIIDSILDYSKLEADAVKLEYSGFSVENLLADCMELLLPMAAKKLDLSFDIEPSVPPWVKADYARIRQVLMNLIGNAVKFTATGFVQVACSVDTTAPRTATDVSLKFSIQDTGIGLGPSDVDQLFVPFQQADNSSTRRFGGTGLGLSISRQLVKLMGGVIGVQSELGAGSTFWFTIPVKIFESEESRQMQSAVEKTIMHLQPLRLLVSSASSATLSMLRTMLDGFDVTTVGSIDEVERRLRNPELVSQQLDFILVDDQSEVRADNLARFVRTLPYQTMQETKIIHLFTPTTDNLAGAPMLRNDMETPPGIVRMTKPPRQFKLLQMLATLKNILDKLPFKPVVNASELREEEALAQRTLFGNVLVAEDNPVAQKLLMKQLERYELNVVATSNGEEAIAEWERHEPGYFSIAMFDHHMPICDGVEACKRIRVLEGKRKVPVLLPIVALSADCQESTKQLCLSSGMNGFLSKPLKKTDLLSLLGMFGPSIPIQRPSPPPTPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW43</accession>
    <name>A0A4Q9PW43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1012666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW43"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5925" checksum="7D6475303257E293" modified="2019-07-31" version="1" fragment="single">HSCARARTVASEVFTEAQSFADCKLHIRTRLLASAFSNFWNTPSSPLSRRISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXH5</accession>
    <name>A0A4Q9PXH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_817844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXH5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000145">
        <property type="entry name" value="HAD family hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="313"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="595" mass="65426" checksum="BFE71C1FE1A9C8CC" modified="2019-07-31" version="1">MSYNMETTFVADAILFDMVAEDLGQDPAYVIPATHGKRAMDNLAQFKPHIKVHEMDVEPVRLRGRIAAFVLALHDRLHSPPVLRATYEDDESMIDRRMELEQKHLFEAWQVEAAAVDRSVRILPGVKKLMDSIPEGRYAVATSGAKTFAYGYMTRVGITPPKEIITTDDKRLKAGKPAPDPFLLAAKELRFDAERCIVLEGSPSGIRAGVASDETVISVFTSHERSKIENCGAHFIVDTMEQYVAGVSDSSGPVIARLHATIYNPIINTAKLGETAANVTVDGGTRTIPFPTRRLRGHQAGFDAMPPGVKMVLNSGEFYGHNASPANLELLSRFYSQYPDYADKTFLMGAVVAGTLVPDGSPENLRRSVTFINEKLGGVNKMDLFKPARVPPNVPIQDDIKTLVELKNEGHFQHIGLSECNATTLRTAHAVYPITSVEIEVSLFSYEDETKKAVEVAKELGVSVVAYSPLGRGFLAGTIKSPQDLHPGDVRRHLTRFEEENFKHNYALVDSAKSIAERKGVTPGQLALAWVISHGPHVIPIPGSSNKKRNLENIAADDIELTDAELAEIDEILAKTPVEGGRYVDLVEKTFHLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY85</accession>
    <name>A0A4Q9PY85_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1917-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_849062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0696 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015034">
        <property type="entry name" value="Bles03"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31977:SF1">
        <property type="entry name" value="UPF0696 PROTEIN C11ORF68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08939">
        <property type="entry name" value="Bles03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="57"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="42404" checksum="12CBD96B11751E45" modified="2019-07-31" version="1">MSKKDDDNISEDYPYQWTPKSEGNLQDFLGKYKPSMVQNDGTKPWLWVAKSDRPREVEDAEAAIKEAADYLTEVTDRVQKIQNDDSIPVRANKKKGLKSKKELREEVQNEATQKLKEIAVRHGYVSGKWLIFAPPEKVDMIWSSLANSLVSGPLSSTSAFLAKVATSPQNDTPNYSHLICVYMPDAYDQGSVTEVMKVLLRNHGINLMGVKTNLYTSIGLDSKHPSGVSSTVWKNTALMKDTEIKALKDEYYAELNAAKTAAVEEAASKKAESGAATRPKPKPKLKDKAGADDPFASDDEGDTEDTKPTSKKAAKPAPSSGSKAKRPVPKKAKVANDFASDSDDGEAEAARKAEVKAKKAGTTKKRKGAELDEEVEEEAPKKKRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0H8</accession>
    <name>A0A4Q9Q0H8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_848383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0H8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="534" mass="60374" checksum="9E0627AE9B3CDF1F" modified="2019-07-31" version="1">MVTATLCSLAHTPDILYRIFSYFDADDLERQYLPGNVYESRRSLVFAARTCRAFADPALRVLWSSLPDDQPLADLLCILGIAARERSLDNQGLSEGNPRRYALPNQYGGFGLYIPDHTYEPRWRQSRGYDVRYFFLHGGDPRRLPQWTRFQQYASYVRAIILFAFDGPRWSKLWEKLRSSIDGAPILPGLSSVSFCCFSSREITQGIFALISHSAFRAGPGITTLRLALPPSTLGPSLLRNHCSYLRHLQVTPRVNVDDLRLLDDLHALEHLSISLSSDLRPLHLTLPSLVTLVIAGHWKDMCILLDTMRLPSMQMLSMTGWEGAQGEADVSATELVTGAIQCFSAISTWHPSITSLCVNSTHTPVEPRGCVVPYLPQVVAPFNGRLIDTIRPLLALRALRYIAIRLPSYFGVVATASDGALMADAWRNLEELHLDVRRYSYGLRMYDPRPCGIPQEGIAHFARKCPRLRVLRLPGMEMEMAKGSRAAGRSASQPRGGVRRPIMPKLRSRLPWRTWRSKFRSLWEGHFRTRRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0I1</accession>
    <name>A0A4Q9Q0I1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922336</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0I1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="7894" checksum="38FCF40AA2757AE8" modified="2019-07-31" version="1">MANGCTDEPVGEASEVAALVSYVVKPKARFLTGESVTCSQPAYYFSDINASSSMRAHSWTHRRKESVTLGAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1K0</accession>
    <name>A0A4Q9Q1K0_9APHY</name>
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        <submittedName>
            <fullName evidence="8">G-alpha-domain-containing protein</fullName>
        </submittedName>
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        <name evidence="8" type="ORF">BD310DRAFT_946804</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU61057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="114155.A0A4Q9Q1K0"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="term" value="F:G protein-coupled receptor binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
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    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="300"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="395"/>
            <end position="398"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="491" mass="56129" checksum="3A853B0BB134875D" modified="2019-07-31" version="1">MPPTRDLSDRDPLSAALRPPIDESEEEKTSRLAEEEAAKRVSLAIDESIRIEKQQRKKQKLVRLLLLGQSESGKSTTLRQFQRLYTPNAFREERVLWRAVIQLNIVRSIHTLLDTLNDIRRRDVYPSTPYTSDPDSDSESESHVQLPTHLEDLRRRLHPLRHIESLLIAKLVPPNEHEATTLGYGGSNSVNGNVGPPWNSRQFAHSSQHKEIFVRPGAAWKLRSHGRPQSAGTTGQETVDESQAVLHHCRTDIVTLWNDPVVRQILRRRKIRLEESPGFYLNDLDRVTSLQYFPSDDDVLKARLKTVGVSEYSFHMEAGDERGTEWRIIDVGGSPTWVPFFDDVNAIIFLAPISAFDQVLVEDRSVNRLEDSVLLWKEVCSNKLLAKVDLVLFLNKCDILESKLKSGVRLQKYVRSFGDRANDPEVAQKYFKSKFSAIHREHSPIPRKFYGFCTSVTVHSLGSRNISADYDFLVAVKDMVLREHLRASKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1M7</accession>
    <name>A0A4Q9Q1M7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_271071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="125"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="300" mass="34145" checksum="1C9DD15E1A93EA99" modified="2019-07-31" version="1">MRRVELLLMRYFRHLSFHEKHGHIQSVFVHRPGRYKLDLYIAAIDIPRPRPTNCSSRVCAGRSIRASDADDVISIPHPQPAPRDKFPDLAMLYQAVRKSVRDLFANQGERNLACPRDLYSGEAIPNGLETSSSVRPHLDLHRQRKDEAAYSSSRASRARSARKFPGPDAQTSGLRQNPQRYLRKKKRNDDAARARRTRSSVVIIVDRDCQSLVRDSPVNVDGRRRWRGRRINRTDLRASCWCPLRSIGRRRNVGDQRSVLTGMQSSRVEKQEAPCGGARPYSLEGALRALFSDTLSPADV</sequence>
</entry>
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    <accession>A0A4Q9Q2N1</accession>
    <name>A0A4Q9Q2N1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">BD310DRAFT_920885</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10955" checksum="2497F22B93624600" modified="2019-07-31" version="1" fragment="single">MDPRGPEAEPDELHNGWGALFKDDEEDEDYAPSECSSDRLSDASDWDPIEAAPETPIPPIYRHNTRVMCERLAFSISRTRTSVVDRVKSILAFMDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2S1</accession>
    <name>A0A4Q9Q2S1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_170983</name>
    </gene>
    <organism evidence="3 4">
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        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2S1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="244"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="671" mass="75995" checksum="3F7013F541921BC1" modified="2019-07-31" version="1">MRLLDTSTAEFRWVNEPRHVSYAILSHVWMKEGEGPAEQSYQDVKKILKQSNRLKLWPTNRKRHSIPRGVSEKIRRCCAIAREHGFDSVWVDSSCIDKTSSSELSEAINSMFKWYQHAGVCYAYLYDVDDDDEPRAPNSQFRRSRWFSRGWTLQELLAPRVLVFISKGWRVLGTKAILATVIEDVTGIERAILTHEASLDSVSVARRISWASRRQTTREEDEAYSLMGILGIHLPTIYGEGRFAFIRLQEEVLKQTSDQSLFVWGLSLQDEVELVDVPSADGAYFWEEREKMAEESLYMRNLFALSPRDFVSSAQTLVLPRHTFVQRLRTILPLSDYTATSHGIRMTVPVLTTSSVHSDVPVHLAILACQDSTGRSLALILRNQDHTSNEFIVGAFLAPTMTISDNDIHGRDLSANGQFSLGELYFRTTRLTQDFLAAHRDSIRVQEIYVPHRPSQARARALPAYGEVQTALTRCDGAFDIQLTGWCQSLLEKDGYVVSPIWYDQAIDLDYPRRRGYELRKSGRCIHIELGVCGCEEGVKNRWLRAVVTAHLAPANPQEPKASVQTDWQRPLAVRHTRRDADHVSSWHFASKFASKQFHVYFGTGQGLTVQLNLSVVSSERASHSCRTYALGVEMFHSESPSAEITPLATASSKRWSPPFVVVDPSSSITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2V7</accession>
    <name>A0A4Q9Q2V7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_172980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2V7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13171" checksum="0E5AE6DBCFD289D5" modified="2019-07-31" version="1">MSLVFARHGLGICVHLPSGITNGESVVLCQFGLRGITTGDDAREELGKYGYADPPLHCLELSCRRHNHIFVHLTVTPRDSFTCTLVGNQSDMSGLRTSGSGGLCLLYRDLSVSISILPVQRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3K9</accession>
    <name>A0A4Q9Q3K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_174027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3K9"/>
    <dbReference type="OMA" id="GRENDMQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="11"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="286" mass="29388" checksum="A232D325D2A757EE" modified="2019-07-31" version="1">MSATLGYSSFFSSGLLAPHTPSAQAPREPSPSTPRASVANLPADDTTPTAHTTTTHAVHESQVLPSISIPAADDSRPRLRRRRSSLAGSASPLTNIKSSGPIRNATASVQRNLRARSGSDASVLSTASAASAANENSNTNTGSKPTGIIGRLRSGSLGTALRPRRGLRRVAPPVPALPPPSAPLPAVPALSSSPTSPLSTIVGSPTSPASPRRPLARRAQTSDNYELTASPFTVAGSSPMCVADDEDAFAASVAALGKRALQDDMQVDYPSPVDGPVSFDWGMARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3U6</accession>
    <name>A0A4Q9Q3U6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_148110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3U6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="40582" checksum="C72798B21D2AC8F8" modified="2019-07-31" version="1">MPTAPVDTRGSVLYFEDSGVPNGSTDYITLFMIHGTCFHSAGFRPIIPFATQSNIRLVLLNVHGYPGSTPYSDEELDRLEGSLEARKAELQARGSELAAFIRWFIITEKIPPISESSHGVLIGGLSVLAWSGGNGHSLCMFAHADRLAEDTRKLFDEYLRSLILYDPSSTAAGTPAPPALKSIRPDRSLPLEEQAIFFGTQASSFYPPFTLPDTIPETPSYAPRVALHEGPGAVDPKLQPTTSKMTTSELRSVMHVPIMERAQHVIWSPLLREVFRENVRRALYDCRHDDGTGAKKKILPAVRVHVVWCDMTLGEVAWAVANLNCEYKEAAPEARRPVEFHKLEGGNHFIHWEEPARFVGVLAKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3W5</accession>
    <name>A0A4Q9Q3W5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_974831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0390 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3W5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3W5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019034">
        <property type="entry name" value="UPF0390"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16967:SF1">
        <property type="entry name" value="LEYDIG CELL TUMOR 10 KDA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09495">
        <property type="entry name" value="DUF2462"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10034" checksum="FE479D958A77451D" modified="2019-07-31" version="1">MVQGQTKGLAKAKNSNARHAQKAASAPKKGKRYVAPKKTAAVKQAAMHKELSAKINKSIEQQVAAAASSGKLTIMKNVAMEGSAAEKTKSTKAKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4E5</accession>
    <name>A0A4Q9Q4E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_844480</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4E5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4E5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="123"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="372"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="498"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="652" mass="72675" checksum="1E26D392AB4BE1D4" modified="2019-07-31" version="1">MLTPATMTHSTAPNQNKRSSKAPAQSLNHLLNFSLPPRQSHHNQSIPRRARKTGNQYGVWNKERFVNAQYRFLMNPTGDYTVHFADPDIYFQWHDILQVIIPRGHSVLHPERQSAQDDGILTCPICLSPPTAPRMTKCGHVFCYPCMLHLLSTSEQLKWVRCPICFDSVNERQLKAVKWLDEVPAAEDVDDSHIEGSSSSTSLDRDQFAAPRSGATLRMRLIQRPQITTLALPRSTTWPSDLMPPHQAPFHFLPDVLAFAKFMLATPFELIQDLSKDLDDLATERRLLSGMGDELGAVFIDAADAKVRHQIEKASALETPHLREAIETARHVAQQFEDRSNLTRHRKAEAPSLPSEEVPEAFLAAQAPGYIAPQPARESAPTPTGRNQRQRRNLNPPPPSTSTYYYYQAANGLPIFLHPLDIKILFSHFHSYPAFPDEITVRVESYTESTVNDDLRKRCKYLGHLPEGADVTFIEADLSLVVGADGLRPFDNALRTRRARRKEKGKRDDKARARAEEREKEKLAQTWHEFGYAPPAPVSVPLDIVREDPDFAAAAAAAATDAPGGEPEEDASSSPPQPWGARSFASAATAAQGRPQQAPRPAAVRNNRGGAEDEWELDMAFHELEQRSAKGGGKKRNNRMVILGGGGGRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4H8</accession>
    <name>A0A4Q9Q4H8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_122754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q4H8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="370" mass="39792" checksum="C31CC0B92910E089" modified="2019-07-31" version="1">MSEDDRAAKAARAKALLKKRQAQKAAEGGGGPPTPRVASPAPRTASPAPSRTFSPAPVEAPAAPTLASVPARDPVPPPVKKQDIDVADLFSTVPSTNGVDSSWLSGLPRVDSDSPPAPSAASSLRHAVQPPPSAASPAAASGDRDDLKALVRDQKRAIEALEAEKASLSVSLDRLSQVESKARQTQELLDAERTKAAELQRAVEQIRANSEQLSHQLQQAQDAASSLKAERDTHAASANELNATLARATQENAKALQTERQNSTRLQEQVQNLDQSIHEYTERVDQQQQTISLLVSEKASLSLAVERLEHAEATLRDTEKRLEDELSRSAKLQVRVSQLESEAAASVTKIATLTEREKELTDKSRDQVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5P0</accession>
    <name>A0A4Q9Q5P0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_956297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5P0"/>
    <dbReference type="OMA" id="MALSGHC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="99" mass="11318" checksum="A2707CA8EE77C8C7" modified="2019-07-31" version="1">MIVNMPPHLVFLERIGTHIFREPSSVWGYLPQVNQWGGIRLEWEAERIGGLDHLPWFKATPIYNGERLEVFSAFGTSKKAAKEEAAKMMALSGHCVFWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5W4</accession>
    <name>A0A4Q9Q5W4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_115790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5W4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33325" checksum="59FCAB4909E68595" modified="2019-07-31" version="1">MIQGMARLVRAYLGYDIYDDRTSLSMTDMHPLFVLASSRHTLATLEVSAYEGVILPHLYPGPFSQLRHLDLPEFLGVSPFIEQNSVTVHDENRKEQQCLGAWKLESAMGGLNELYLSGLSCEVQDLTVFMESFTSYTMLGQLLSNARPSTLYLRTPQPGVLKEDTALPALLRCEGGAQLTALDLHIEFSPEDRDIDLEAGLACLRAALSTTPIRLLKLYLWCFDIPFLEGADVGGLAKTFLDTISPLEMIRLEIGGHRTRENEPFNALKGGEIVVVNKEVPNMVSMHDVDMDSEDGSEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q623</accession>
    <name>A0A4Q9Q623_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycosyl hydrolases family 31-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_871124</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q623"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q623"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030459">
        <property type="entry name" value="Glyco_hydro_31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF133">
        <property type="entry name" value="P-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00707">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="324"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="8">
        <location>
            <begin position="755"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="976" mass="106312" checksum="13A053D0DBE1F45B" modified="2019-07-31" version="1">MLATFLGGVLLMGRAARDHLSLLTSSFTAEVFATQETFSRNVSTCPGYTLSSLHETKTGLTAALSLAGPACNAFGHDIANLTLEVTYDTQTRLHVNIYDTAKAQFTIPTSAVELASGSNDPSLKHSSDLVFNHESSPFAFWITRRSEPDAQPLFDTRISSLPPAPIPPNNASDSSTGFDGFPLVFEDQYLQLTSALPLDANVYGLGEVVAASGFRRDVGTDGSPGTIQTMWARDAADPVDENIYGSHPIYLEHRFNETTKKSQSHGVFLFNAAGSDTLLQTPPASPVSLIQYRVVGGVLDLYFLSGPSPQAVVEQYGAVVGLPTWQPLWGFGFHLCRWGYTTVNETREQVRQMRAAGVPLETMWNDIDLYHAFRDFTTDPVSFPIDEVRAFIAELGANNQHYIPIVDAAIAHAVNDTDIYDTFARGTEKDIWIKNPDGSTYIGQVWPGYTVFPDWFAENTEAVWTEAFKNWSDSGVAFSGIWLDMNEVSSFCAGSCGTGVDLSIPPTQVLLPGTPGDLVTEFPEGYNATIWGPSGNMTINGTSTFGNNGETENTLVKRGLGAGQEKQVNLNSPPYAIHNGFGLNDLDEKTIATNATHANGLVEIDTHNLWGLMEEKATHLALLSIHPGKRPFMISRSTFASAGKWTGHWLGDNYSKWAYLHYNIQGVLQFQLFQIPMVGADTCGFNDNTDEELCNRWMQLSAFVPFYRNHNELGAISQEPYRWDSVAEASKTAIAVRYSMLPYWYTLFANASSRGTPPVRALFFEFPDEPELFGIDTQFLIGRDILVTPVLTPNVSSVAGVFPGRGDTVWRDWYTHEAVDVPATPGGNVTLDAPLGHINVHVRDGAVILLYAQPGYTVTETAAGPYSLLVTLDKGGHAFGTAYLDDGESVPPTPNTTLTFRAGEGQLAIHSSGNFHVGQTIDTVTILGVGSSKPGAVKANEKILQVADWEFDEGLGRLVLKDLGLDLNGESTVTWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6F9</accession>
    <name>A0A4Q9Q6F9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_809952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6F9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8747" checksum="6522EFCB83AC89E8" modified="2019-07-31" version="1" fragment="single">LPGELVDRIIDHLYNDASSLKATSLVCKTWLPRSRFHLFQAVVCDMAPPTTSVSALVSLLYGCPDVAPYVHKLKLVHID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6R5</accession>
    <name>A0A4Q9Q6R5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_871823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6R5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6R5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="869"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="878" mass="99689" checksum="0B0D18A3345CC6B0" modified="2019-07-31" version="1">MDQLCDEILQLILNELNSPAAFAALSKRHYEFGKDPYVRAMYFLARHGHIQALYWALGRGRLLNERVLDILLGSGAHLSRYLAQMAIHHYFRTQVSFIKTRWVRTLTLPVFTHFLSIASRLYGDIPVGKGEDDGTILSLFLKQSRFPTEYRAAKWEQVRDVVEKYKFIPFSDRDPMMAQYPLVLAIEPRLLPFARQNGFHMDRKYRDFVFRRMFEKPAVMFESRADEIVQNVRELSRLDTDMFLSRTVAAEICMEAKTNEPAYAALKRLDKEGVLRFELSSVVQDLIKLFLNTRSVTTTHTASVLRVLHKDFPSEDPTVRLVLLLTVFLSDPSHLPESLVPTPNTAGLFERYVESCSDEIEDMNLGPLTRKDIVDILLSKFVPERFGGILEYARSVLDLDKEAMRCVITEVALGCLEIGCKGRMLAKLVATYSYLSDVIASHIVKTYRIQLEDLPPAEDEKACKEFAAPLCADLLLMRKGIPMTFEEVAAPLVPPTVEPAPPPQPESEPAENEEEVGAGEDEVEEGAEGPETPAETEGEDLGVIGQDTLSAMIRKDEMQPSRRRRYHELYTNYHDSIGKLPYPADYTQVGTWIQNHYGHLSAVAAVIRLHAVINQNYTVLHHYLYNGDGPAHSGRVPTTLKQFKILARLGRTPSMSLYDDIEAGTEFYFSEEDYLSQEELNGTAQPPLKKATRRAKVKCEASPTPGPSSAGMSTSRQAEAAGPSAGPSAGAGSQGRKRPRRSVASSVKSYVVPDSDDEDIVMEGEDDILQKFAKKRRQETNMQRWIKQLAILFKEEQRKYNERKRRIHTLSPPGAKVKVPKTEFHKSLAFNLPRLRRIDRVRREKLYGTDIADVDMSESDEDEYQYRTTRSKRRKVEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7Y0</accession>
    <name>A0A4Q9Q7Y0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-trefoil DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_915647</name>
        <name evidence="10" type="ORF">BD311DRAFT_710329</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Su(H) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7Y0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7Y0"/>
    <dbReference type="OrthoDB" id="5600360at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1450">
        <property type="entry name" value="LAG1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015350">
        <property type="entry name" value="Beta-trefoil_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036358">
        <property type="entry name" value="BTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040159">
        <property type="entry name" value="CLS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015351">
        <property type="entry name" value="RBP-J/Cbf11/Cbf12_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037095">
        <property type="entry name" value="RBP-J/Cbf11_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10665">
        <property type="entry name" value="RECOMBINING BINDING PROTEIN SUPPRESSOR OF HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09270">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09271">
        <property type="entry name" value="LAG1-DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01268">
        <property type="entry name" value="BTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01267">
        <property type="entry name" value="LAG1_DNAbind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110217">
        <property type="entry name" value="DNA-binding protein LAG-1 (CSL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RBP-J/Cbf11/Cbf12 DNA binding" evidence="8">
        <location>
            <begin position="173"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-trefoil DNA-binding" evidence="9">
        <location>
            <begin position="306"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="644"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU34621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="79382" checksum="471E16C46F50CFA7" modified="2019-07-31" version="1">MRTIMPFASNPLHLQMSPTQTTEAREHMPTSLNPQELSRSASPQQSNLSLLVSNGHAALRSPPAGVAHSSIPPSHQPPPPSEPSVSIQSILSNPAPPVPPPNGQPPPWSVSNASSRDTSHAIAGPSSSSGAPQRTSTKRKLEPPDAADPHNKIRRVVRDHITQDPARVMPMTTVICLHAAVAQKSYGSEKRFLCPPPVVHIEGPVWQMKHQHLSMAVVNEGGERTCELKAPMDHALTASFKFLHVTGSAKSKSFQLSLDIAEPSPSAPDGGEATGNERVWASFDSAPVTIISKPSKKTAKTRNISSCILAGGPVSLFNRINSQTVRTKYMTIEHNQLCASNIAWSAFAVNVVRSQGSENPLGGPQPVTYGSEIVLADTVTGVQTAPLIIRKVDKGRIVPDDGGPVSQMQKIALQRVNGDGTRHYLSAAGPIPGTPGVTVPPAPGLSNQAGTHPLLFQSPRIREEMKDGARVITDEVDDYLCWTIVGISKFQYTFFDAFGLNNSVPEMPITPFPTLFNTPVYRSQSNTLEMMAANFFYMDPKTKTQMPLDVYIGNIGPLRLRVYNHSPLSMDGRFDPAMPFIPVPPLPNQPPGAPVLASDIQSRDNKPADVVLSLPARHLHMMIVAEMPPMPDILKALREDALPPAADAADKSQDASGSRGSNLMRDIAGRSLPLLFIRSYDGVGYHSGRVVAADNVLHAMDLSNPARPGAEGGDWLAAAQAAARLSDDTSMHGWNLKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8S7</accession>
    <name>A0A4Q9Q8S7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1793-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1013753</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8S7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8S7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF1">
        <property type="entry name" value="GLUTAMINASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020900498" description="DUF1793-domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="103"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="339"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="620"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="710" mass="76632" checksum="A9E71BED1700A2BC" modified="2019-07-31" version="1">MYSRTLLVAGAALLGPVLGASWTATPFNPASVPLAVRTPYLSAWLAQGAGTALNDAWPTFWTGSILGWAGYVKVDSTTYTWLGVPNVAGPSKATQKSFQFTSTQSIFTLSAGPVDLTATFLSPVEPSDLVNQSLPFSYLAVSVKSNDGNSHNVQVYTDISAEWVTGDNSLVANWTTTTGNVLTHQVQLSSPSVYSEVSDHTQYGSAYHATLNTVGATWQSGQDIVVRQQFISNGALANTADTNFRAVSNNWPVFGFAHNLGTVGTSATAPVVFVVGHVRDPAIQYITANNGRQDRSVLFWTRFSTVSSAISTFINDYANALARANAFDAKVKSDASKISSDYADIVALSVRQALGAIEITVSKDSTGKFNTSDITTFLKEISSDGNVNTVDVVFPSWPIFLYTNPAIGKQLLLPLFEYQATGQYPNKWAVHDMGSSYPKAVGHNDGQDEAMQVEESGNMLIMALSHAQKSGDNSLLKTYYSLLDQWTQYLIQDSLIPAEQLSTDDFAGKLANQTNLAIKGIVGIAAMSKIAGIVGDTARASNYSSIAASYVQQWQGFALSSDKTHLTLAYGNSSSWGLAYNLLADKLLGTNVFPKSIFDLRQFQFSVPLIRKADIAHRLAETQWYSSHALSYGVPLDTRHTYTKSDWEIWTAALVTSTSVRDLLVSSVRKYAADGKSSQPLGDWYETADGSVEGFRARPVVGGHLALLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9Z2</accession>
    <name>A0A4Q9Q9Z2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_806240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9Z2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9Z2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="104"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="587" mass="64090" checksum="E5AA4CF98333746C" modified="2019-07-31" version="1">MAQASIASLFTPSSKSQHATQPAYHPSASLSFKASHARKHSELEDAFAPEATPLKRPRVTASSRLQSAAPLAERLRPRSLDEFVGQPHLTEPGSLLMSHLDRGATGSIIFWGPPGCGKTTLARLLASRTDAVFKELSATDSGIADVRSVVEEAKNLLALTGRRTILFLDEVHRFNKAQQDIFLPFIEQGHLQLIGATTENPSFRLTSALLSRCRQVELRRPVFILERLTDEDIKKIVTQAVERVLETFAPSDRPSRISLPTPSPNDLHVIDDDSSDVASSQPDIEEPLAHPSSTQGSVASASAGHSTTAEPTPQFPTLPQLTPKVLSSIVVLSCGDARTALSLVELVTSAPTDSDEGKLLAALRRSVATAYDRGGDSHYDMISALHKSVRGSQGNAALYWLARMLTAGEDPLYIARRMVVCASEDIGLADNHALPLAMATYQACQVIGMPECRINLAHLVAYLSEAPKSTRSYEGYNRAEEAAKLDPSVPVPLTIRNAPTKLMKELGYARGYRYNPEYAHPVTNDYLPIQFRGDEFLRKEGDTANKTWDEDALRQWEFEENGGRPWPGRPSEGEQAGTARRGDVSQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAW0</accession>
    <name>A0A4Q9QAW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_838218</name>
        <name evidence="12" type="ORF">BD311DRAFT_708957</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAW0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAW0"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU34975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="12998" checksum="3C2FEAE5EDFB78CD" modified="2019-07-31" version="1">MANQQDRNLLAVIGDEDSVTGLLLAGIGNVGPNQSKNFLVVDSKTQIPTIEAAFEDFTSRKDIAILLINQHVAEKIRPLVDKYQEPFPALLEIPSKDHPYDPSKDSILKRVQKLFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBA4</accession>
    <name>A0A4Q9QBA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Maintenance of mitochondrial morphology protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MMM1</name>
        <name evidence="9" type="ORF">BD310DRAFT_838615</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MMM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBA4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21671">
        <property type="entry name" value="SMP_Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03103">
        <property type="entry name" value="Mmm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027537">
        <property type="entry name" value="Mmm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019411">
        <property type="entry name" value="MMM1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466:SF0">
        <property type="entry name" value="SMP-LTD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13466">
        <property type="entry name" value="TEX2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10296">
        <property type="entry name" value="MMM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="6" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="38"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="34280" checksum="65E645EBE539722F" modified="2019-07-31" version="1">MGSAYIFTLQPTFTQGLILGQASILFLLFLILKYLFFDTDPERSSRKASYPPKIDFDSSEEDVTAARFNLDSFEATKREGDSESSEWLNVFVQQVLNAYRAKLRDGLSGPDGDEIARRRVEEFANKMRPAGLLDYIKVHSVSLGSSAPRLSNARIRRDLSPGSDPEIDYDMSYVDTVAISISTSVLFNYPFPSFARLPVSLTISLSLFAAPVRLTPPHPHSPHPTITFTLPSPHSDFTLDIKTTSLMGSRAKLEDVPKVHELIQNQIRRVIMDKGTWKVVLPGLSSVSQVKEDMKMERELADETFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBU1</accession>
    <name>A0A4Q9QBU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_805823</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBU1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBU1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="92"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="694"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1238" mass="139022" checksum="B7CE078B57A2FEAD" modified="2019-07-31" version="1">MAYAYYLYDSPLAGAPSMGLTTVPIRYVAPQDDTIENIYRGRLLPLLLTLVQYHPNHLPILLLLACMYHVLGDYHHSLSISQQILSHDPEYVEAMSNIGTTMKALGQTEQAYEWWWKALQLRPTYWDALDNILGMTFQLAHGTSDQGRRLAYYRQALGVCQFVQRHVFDADGHLSASLRPDEVPRLQRAIFTSGTIYSTIGPTNTGRAVSELARAIELVIRPPPPLSHFELYTLRDLLLAACVAGHIMSSSANSPGIIELSDIFQADVSTSLGDPTFNLLHVVRTSSDQLLHTLLRVGDGILPTPLLVPEEVVRLQPLLFPWSKGVFPAICTRTADGDLVPPADSTLQQTNGMTSTVLLTLAKRFQENALASTVFPGTGDGLRVSTTVVVLLYYLALSRAPAPSTYNNLGIVISGIAETRRGPGGELLDGTALARIFYSAGLKIEPQHPHLLTNLGSLLKDQGQVEQAIKLYMKAIEQKPDFDIALANLGNAIKDIGRPWDAIEYYRRAAAVNPSLPEAVCGLVNSLSAICDWRGRGAVENEVGVDDTGHVISSEPPLHTGWMARMVSITDEQIKEVYLQGIDGAHIPTVVDDCMRALTIMKDRLLRPGEAALWRARFHLIAGSGAELAEKHVNGSGFLIRFIDWIIPQMQRRWYVKAYGKTIALDQIVPLVEDHFTSVFVRPKFPKTMQVPLVPSVLPFHTFTYPLSPRVSRLIAHRNALRASYVALSQPWMPSHVCRPPRPPVQGKLTIAYISNDVNNHPLSHLMQSVFGMHDKEQFNVLIYSTSPWDGTVYRPRIASMVENCFDVSAWSLKQIFNHIQQQEVHILINLGGYTKGSRNDVCAARPCPIQMQLMGYPGSLGGNWCDYLVCDPIACPQDLSGPERWRSLRTAGDNVTSSSQSTQSIETPLDLGADIDPEDISNEWVYTERLLYMPHTFMVADHKQSYRGDEHISAEDRARMSPETLWLEEERRRADARRHLFPDVPQDVVIFANFNQLYKVSNGSIFLVWVRILRKVPRSILWLLRFPSAGEEHLLRSARLWGGDDVASRIHFTDVAKKDWHVYRARAADIFLDTAECNAHTIAADVLWTGTPILTWPKHRHKMCSRVAASMLQATGFADHMIVHSAEEYEARAVALAHSIRYVPYHEPSRAVIPRGQGELMNLRRNIFLNRDNMPLYDTLRWTRNLEKGLREAWRRWVEGTQYETSDEWEACDGPEKRSSCIWVQDDDPVNIVTHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBU5</accession>
    <name>A0A4Q9QBU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_306035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBU5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18905" checksum="2EE8FA36A3D304C2" modified="2019-07-31" version="1">MQTRKTAPMLRRHSRSSPTTSGWRRKSNMTLIDTRRNAKTTPADSVIVVEASSVVQSFHATQAKNTVGLILHPKATRSRSAHRDEMLSPHFLQTTKERTIEVSLLTTAYTTAQRRYQYTIYTRDYACERAEKSGNSRGIPDRHFRVRDGGREPEVSMHAGSTWDIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCF6</accession>
    <name>A0A4Q9QCF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_6164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCF6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCF6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="135" mass="15589" checksum="2553EB684562BB6C" modified="2019-07-31" version="1">MLVKWDFEEIEVTWPAASDADLKFVRELIEGDKVPDDSRLQVRCAQVLTPAREDLIKSTDTSVRLFTCTMRQGTFSIRLSSAFRRKRPPVLQCSTLRSSRGQRPIAQLSMEQCSGMCTAQRCSRRRSFRWRCAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCH2</accession>
    <name>A0A4Q9QCH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_983336</name>
        <name evidence="6" type="ORF">BD311DRAFT_3662</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCH2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCH2"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="5">
        <location>
            <begin position="124"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="299"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="573"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="605"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="474"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="659"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="673"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU35483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="717" mass="78345" checksum="476347B87D241A12" modified="2019-07-31" version="1">MRLTESNRDSALSVSPDSQPEAGPSSSAAGPSNGYKAAVAKTNGFSQPYTNGVSKLASSGLLDGPAPEKHRSSVAKVSIPGRTLYDDSFVDREEFVRLVIQSLRDVGYTESATTLEAESGYIMETPEVAEFRRCILTASWDSAEAALMRLGVTEGEGLWEAKFLIAKQKYLESLEAGKTTAALHVLRNELAPLNPELDHLHALSALMMCSDPADLRQQIGWDGAAGTSRRRLLTELQRYIPSSVMIPQRRIATLLEQARAYQQSQCLYHNTPLTNRSYSLYTDHSCDRNTFPRVTTAVLQVHSDEVWNLEWSHSGRYLATASKDKTAIIWRIELDKDARSRAYSPEFVLRDHPYPVGCVAWSLDDSILLTAAEHFIRLWNTRTGDCTRVLNQHTDVVTALAWLPDGSGFISGGLDRKIILWDADGKMRDKWERTPIRVTDLIVTPDFTRLVAVGMYDMPSIQPGSNPQESVTPAGSGQAQNAAANANKSSSETRIIIYDLHTKQAETYIRLDGELTSVKISQDSQYALINRASENGPPAEIHLLDLASEQVVRKYSGHSQSKHVIRSCFGGVEGNFVVSGSEDGNVYIWHRDTGALLEVLEGHGEGSVNSVAWNPVNERMFASCSDDKTIRIWEAPPSEVQSSLLVADEPCDMHEADHELENGKDKGKGRWDAGAGPSRSSTASTSASVGAEPSTSGRGVDPEGGPGYGLGSTTALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCR9</accession>
    <name>A0A4Q9QCR9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911567</name>
        <name evidence="1" type="ORF">BD311DRAFT_744458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCR9"/>
    <dbReference type="OrthoDB" id="2777543at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU35711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="593" mass="66968" checksum="2BF7C3DC70D4BD09" modified="2019-07-31" version="1">MATVSALPVVVPLLPAVDEFDQPRQGNSSTRLTLSQLLNPALWDLPEWNGPHVEDPNNIAAQVDSIDYSVALLKRYRNSLRPVHRLSPDIMALIFLELLDDHDHPLGSTFGSCSWSYLAHVCHRWRAIALACPSIWTQISTRYPEAALTCLERSVDAPLTFVIDSRATMDNSKDVVDRVLLQMSRMRHLYIPWTLLHDDDGNVSPLVSGLIDASAPQLETFYLYRVRADGKCFALPPIFGGQTPRLTVMKLSYSYPQMGSVTFGNLKELYIRGRKRDLITLELAQLLDMLEACPVLEVLVTIKARFVHNQPLEEDDQARRQIRLDNMKRIDIARCAASVVTNLLDRLIVPNCQLRISVWLERRSDFRFTWGVPEELSENHPLRDIRKLQIAYRSGSGGVIVEGTTAKHPFQVIATIGTGSDIGDMPTVSGQLLESIAKTLDLSLLEEFTIAETSYYHPHVGFSKDVWTSVLSRMPLLRTLHIRLQSITDSGFCRVILSALTHRDDITGKLVCPLLETVTLVDDKTWSSLQWWRFAKQRRDAGHPLRRLSLCLPHYENVEDMASTDLTDLREVVDAVDLDPPDTPHVEFPSAAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD39</accession>
    <name>A0A4Q9QD39_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_963983</name>
        <name evidence="11" type="ORF">BD311DRAFT_801862</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD39"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD39"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000211">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU35194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="460" mass="50161" checksum="62445A346C3E0325" modified="2019-07-31" version="1">MGKEKTHVNVVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAELGKGSFKYAWVLDKLKAERERGITIDIALWKFETPKYMVTVIDAPGHRDFIKNMITGTSQADCAILIIAAGTGEFEAGISKDGQTREHALLAFTLGVRQLIVAVNKMDTTKWSEDRFNEIVKETSTFIKKVGYNPKAVAFVPISGWHGDNMLEESANMPWYKGWTKETKAGVVKGKTLLDAIDAIEPPVRPSDKPLRLPLQDVYKIGGIGTVPVGRVETGIIKAGMVVTFAPTNVTTEVKSVEMHHEQLEQGVPGDNVGFNVKNVSVKDIRRGNVASDSKNDPAKEAASFTAQVIILNHPGQIGAGYAPVLDCHTAHIACKFAELIEKIDRRTGKSIEASPKFVKSGDACIAKLVPSKPMCVESYNEYPPLGRFAVRDMRQTVAVGIIKTVEKTDKSGGKVTKSAEKATKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD75</accession>
    <name>A0A4Q9QD75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_953748</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
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        <property type="entry name" value="Myb_DNA-bind_6"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="499"/>
            <end position="583"/>
        </location>
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    <feature type="domain" description="HTH myb-type" evidence="12">
        <location>
            <begin position="926"/>
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        <location>
            <begin position="926"/>
            <end position="975"/>
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    <feature type="region of interest" description="Disordered" evidence="9">
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            <begin position="1327"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
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            <begin position="133"/>
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        </location>
    </feature>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="10">
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU65625.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1352" mass="149232" checksum="D66959CFC405D31A" modified="2019-07-31" version="1">MMSHLTESLVEERVMQLQEISRRRNELLREMYHLVQKRDKLGSLVTLEEQEESHDDGLQSFLDRFDLERHPEMGSISNLLEDEVALPETPPAYSPVGVPEPEPMAETADAANVISESPMSDPPASPTIRERQEEEEEEEEKEKEERDSPIPDVSKVEALMDVDLPPPVLPPEEPTVPEAKPDMTQNVRSPELPQVPETARQSPDFVEGELHPTQVAIPGKSPTPAPERLVTPPYIAPSRDSPMPQTSTGSVAATREPSLSRISLPPSQRVRSPSQRADFEPDGIKAEPLDDEDMGIMDSQPQVRSSSPEERTAVPFETVTPAQLMKEPSEDQIMTILGPTDPRSSPAPTDEHVSYPVIDYAIPLPTPGSPTSFSFNDGADQPMPVEYTRGPHQFPPDPPYPRPPLELLPLEFNWKKPSKKKNKGADKSDPKTHEWQPMGLNKWAAVLKANPVHTKLQRATKCLSTRDWSIGIAEMHLLRVFERVDKLKDSGQWSFRQPKKQRGVGGLMKTHWDYLMDEMRWMRTDFHEERIWKIALAYNLAHAVMEWHEAGSLEERVRRGIVVLWKPPPLEDTEMADGVEIEDIDGPFRDAQDVDEDGGDSRETVTPNDGYGSDDESEDELDKEPANDSLEPGQALQDALEQLEQEPLQGDGQDGVHFKPKLEEIEDLTALGDGSSGREENVMEVGVAKALETQADKPQEMQAPPKPVVPEAHPGLKASSKNPVLGPTGREGVKEKIKYDSIRDHILYSDTRKLFIDLDDLDLVKHMSALTTNDPPLPPPPHDLAQLFPDCGVYGMLDVAPPPTFGEDNRKKPDRRISKDDPDRRIDEAMYTKLTPTSKFMFEKPVLLGTLRPASNFKDGKWSQIEEAPVFVDIDIPPAKPVDDNPCVLFEGTATKTSTPSGHPVFMPPPPRDVRKRNAEQADSLSWTPADDALLKQAVERYPHNWNLIADAFNSSRVTISTDKRTAWECLERWRGKSSTAARGDAAEDNTSSVASTSASAHMTTRGLKRSATQSATTSANGAASSASQSEPRKRRRHAAIHDTIKRAAKRREQAQKSNPPRAKTTAVHDTHGQFTKLPKLTPAELSRMKTEKEASIVAQESLVRRRNDELARQHLLREQARTQTQTLPPNAQQPQTPQGQMLPPGATPNGIPRPQNGIAQVQPIRSSQVGISQQQRIAALANANARMSPPHLAHAGQIRVMAGQAPAPAPASGQGQVQAAGQVPHSNASAALTAAAPALSAAHLSPSFAARATSSSPGAPHRSPPLPAASPANANVPRPPSVPGQPVQGMQVNPLLQVQGLHYYMQSNRLTAEQIQALIAQQQQRSQQQYAHMHHQQQQPQNPPNGNFPHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDW0</accession>
    <name>A0A4Q9QDW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">GTP-binding protein lepa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_804718</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDW0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDW0"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16260">
        <property type="entry name" value="EF4_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="7"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="140"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="623" mass="68978" checksum="EFD4FFA068265076" modified="2019-07-31" version="1">MEDYPCEVIRNFSIIAHIDHGKSTLADRYVKQLLLTNTITKKDKGLNQQVLDKLKVERERGITVKAQTASMFHEKDGTNYLLNLIDTPGHVDFSWEVARSLAACQGALLLVDASQGVQAQSISVFHVAREKGLTIIPVLNKIDLPAAQPEIVALQMQSTFGLDPSDVIQISAKTGKGVEKVLQAIVNRIPPPVGDPSAPLKGFLFDSSYDRYRGVISLMSIQGGVLRKGDKIASCHTRKKYEVTELGIMHPEEVPTDCLRPGQVGFVACSMKESGEAHIGDTFHRVGQLVEPMPGFKPAKAMASVYAGIYPVDSSDFLKLEESIKRLSLTDRSVEVTRETSSALGQGCRLGFLGTLHMDVFRQRLEDEYDANVIITAPTVPYQIVHRDGKTSLISNPTEFPDPSEFASGGRVRAVLEPIVKASIIVPEKYFSAMMDLCFEHRGTDLDWQPMEAPGQADGGEAMSNRVFMSVTLPLAEIVTGFFDKLKSRSSGFASFDYEDAGYQKGDLRKMTFLLNHKPVDALALIVHAKAVDETGRYWVEKLFKIIPRQLFEVPIQAAVGNTIIARRTLSALRADVTAGLYGGHYERKLKHLQNQKESKRKMKRVGRIDLPQEAFFDLLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDX7</accession>
    <name>A0A4Q9QDX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidase family C78-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_36580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDX7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDX7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="3">
        <location>
            <begin position="139"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="478" mass="53444" checksum="7724DC59876B2A43" modified="2019-07-31" version="1">MGEQAPVIDDGELEILAQNDPKKIICQICAEDLTPMTIIQRDCHYDEHFEGPSRASGSGSSGMTGGTLQSPQAPKPPSKLSSMRPRSGFRPLSFHNTSPEEQNIFWHSGMTSEPPRNFTPGLMTVLKKALNRSHDKGNTQRAWLCMETAVYIQGEHWDRTWGCGYRNYLMACAALMNQQLQPDYFPLLDTPSSPGVRNLQILIERAWRDGYDEEGAKDMDRKLVGTKKWIGTAELYVAFTYKGIPAQLVDFELHNGVEPLLQWVLQYFSGEKPHRKSTSSTVSERLLGARAVTITHRPPIVLQHAGHSRTIVGAEQVKGGIIHLLTFDPGRRLPPSIRQAGLKYHDPTRSGGTQGPSLSKKVLHNVLHPVETMKSRKRKSPEPQGGSPKRKRGGNTGSREVIVIDDNDDDHRKVKPPSSSNQSTFDALSPADVLKVFRLDAKTLNKNKKYQILYFPMTEPLSEAEKLNRRIVTSEKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDY2</accession>
    <name>A0A4Q9QDY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_912612</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDY2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU66033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="238" mass="25805" checksum="F98A3C5E17BA566C" modified="2019-07-31" version="1">MPAPDKPATDTSEIVSPSEENATDTRRLGLKFLLRTLALSLTLSNCMACSVACGYAAVHFLLRVTSPPWLDPSGMFKSASLLGTAFTTRHSGWLIYIPRGLIASFVPLASASEHKPSPAGSDERTAEVRRWWARVTAPVPPCVVRVFDLGLIMAAGPLGALLQDGRDVYGEVGLDPWHATIASVVLCVLVMATSEAGGWMLRCRSKRCTTGVTDQKNRETEQMEKGLEHDDSPKRLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDY9</accession>
    <name>A0A4Q9QDY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_911373</name>
        <name evidence="9" type="ORF">BD311DRAFT_860119</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDY9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDY9"/>
    <dbReference type="OMA" id="PVSNDGC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU35608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="214" mass="23932" checksum="087C9A05486F6E12" modified="2019-07-31" version="1">MSATTPVTADFSSPPLKRSKIVLLGDQSVGKTSLITRFMYDTFDNTYQATIGIDFLSKAMYLEDRTVRLQLWDTAGQERYRSLIPSYIRDCSVAIVVFDITNRQSFLSTSKWIDDVRSERGNDVIIVLVGNKADLSDKRQVTLEEANAKATQLNIMFMETSAKAGHNVKSLFKKIAMSLVGMEKENEQSEAQNTKIDVTSPPQNEVPDASQCQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QER6</accession>
    <name>A0A4Q9QER6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP-NAD kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QER6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QER6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF31">
        <property type="entry name" value="ACYLGLYCEROL KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="102"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="481" mass="52638" checksum="FD8CAD1DD5F9DFDC" modified="2019-07-31" version="1">MASHSLHLGSGTNTSKFTLTEKELVLEQPANKKWPLVRTSLRNVLWAGIDDGNRLQISVLATKKRKSPLSLVHVAGVVPDADIDSAAAFTSSVMHSAYYGLTPRRRLKVIVNPKSGPGKGAKHFRKRVEPIFRAARCHVAVTFTSRARHAQEIAQALPLDDFDAVVVLSGDGSIYEVFNGFAAHADPARAFRMPVTPVPTGSGNGSSNNLLGREAAKDLAMAALNAIKGHPMSIDLVSILQNGKRTISFMTSCLGVMANLDLGTEHLRFMGSQRFVVGFLREVIKHRSYPYRVSIKVAESDKYKMVETLDAVRAHAQAVHGTAASPYNASAAPTSKGLPELKHIGPGADVDGDGWITFAKPVMYVYAGKGPFVSKDLMQFPVSHPDDGLIDVVISERTTRLAMIKGMDGSERGEQYWMDIQHYFKAYAYRVEPLAPKGYLSIDGEAYPHETFEAEVHQGLGTFLSMYGHYMNDFSLPPDRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFI4</accession>
    <name>A0A4Q9QFI4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_972010</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFI4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFI4"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="11"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="253" mass="27091" checksum="6188F50E397C2547" modified="2019-07-31" version="1">MKVVPVPVRDDNYAYLLIDDASNQAAAVDPYDVRKVQQAAEKAGVQIIAALTTHHHFDHSGGNKDFAAAYPDAPIYGGSEKIPALSKLVKDKDEFKVASINVRCLATPCHTQDSICYHVTDAAGTHPGGVFTGDTLFVAGCGRFFEGTGAEMHAALAKLGALPAATVVYDGHEYTRGNLAFAKSVDPENPALRRLDTLIQSGVVPSERTTIGDEREWNPFMRLDTPAIQQATGGGEAAHVMDALRTLKNNFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6M8</accession>
    <name>A0A4V2K6M8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_995867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145236">
        <property type="protein sequence ID" value="TBU52813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6M8"/>
    <dbReference type="STRING" id="114155.A0A4V2K6M8"/>
    <dbReference type="OMA" id="HERMNDE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="935"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1031" mass="117424" checksum="2C0496DC748E171E" modified="2019-07-31" version="1">MEWQYTGSLTKSGGELQRLVDEVLLDDRFQKEDLRGFNLDREQRRLDEHALTGGAFSTQDGWREASVMLHLPKPGLEQEDEEHCPAFIVNNIWVRSMLEVVKCGFQDISARKFHCVPHKLYRTRTTAEEPNAQPERLYTDLYNSDKMIEEHERLQKRPRNPADAPEVEYVVGGIMVYSDSTHLTNFGTASLWPIYAFFGNLSKYLRLKPSMFAAHHLAYIPSLPANLLRFYEDTYGAPASAAVIRMLKYDLVQKIWLTLLDADFMHAFEHGVLIVCGDGVTRRVFPRIFTYSADYPEKCLVACLKTLARCACPDCTTDKCDFWKMGMKQDMAARVKNARQDTSVIQQLIARVRRWIFEDGTVPDGNSVKKTKLGFLSMTPTRSAFSQRFASFGLNVYELFVPDLLHEMELGVWKGTFTHLVRMIIAAGGDRVQMLDERFSMLPTFGRATIRRFGDTVSAMKKLAARDFEQMLKCAMPCFENLLAEPYNGIVLDMLFELARWHALAKLQLHSETTIAALDTSTGTLGQSMRAFLRHVCPHFATQELPKETQSRQRHKAASGRNKQSAMASSKFRAFNVLNTYKYHRLGDYARGISEIGTTDNTSTQTGEFEHRRVKQFYRRTNKNRTFGRQIALEVRRAEIINKIKQTWGETVKPRNKRHKAKVARAARGKRLHVRFEHAEPLPPTQPDRHYHVSDETRYPVKLEDFLFENHGDPACENFEWDLKAHLLRRLPGGQALPPDYIANFDDVFSVRIENNRLYRHKVLRINYTTYDMRRAQDSINPRTHPDIMMLAPEGSPHPYLYARVISIFHIEAFRAGDDLDGAGDTDMQTIQVLWVRWFDLDSSAPGGFKARRLPRLQWAALDDNAFGFVSPDQVLRAAHLMPAFAHGQSDSALPGYSIARQEDEDDLDWNRHYVGIFADRDMFMRYYGGAVGHQRGDPGARHAPPVAPEPINPLTGDLYDDEPEEDGSHADADGVNSDGEDGELTGSSGNNSEEDAETEEDDDDDLGPEDGEVELGEDERELAQAGFAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6V1</accession>
    <name>A0A4V2K6V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Sodium/hydrogen exchanger family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_135850</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145208">
        <property type="protein sequence ID" value="TBU53663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6V1"/>
    <dbReference type="STRING" id="114155.A0A4V2K6V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="28"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="479"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="591"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="683"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="755"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="787"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="824"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU53663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="869" mass="95532" checksum="28BCCBC7A2970D83" modified="2019-07-31" version="1">MRFNPFEVSIPHIAYAALGGFVVLFGMFSLFIRERLYIGEAIWAFLFGVVIGPYGANIFDPRGWGGGDRETINTITLEVTRVILAIGVFAIGVELPKAYMQRHWKSLLFLLGPCMTWGWFVSGALIYALIPGLNFLSSLAVAACLTPTDPILAAAVVGGKYADKHVPAHLRHLLAAESGCNDGAAFPFLFLALYLIVDPSTGRAVSDWILLLWLYQVVLGIVFGALLGFGFRHLMKFCERKDLIDRQSYVAQYVSLAMLTIGATTLLGSDDLLAAFSCGTAFAWDGFFNKQTEESVFSSVIDLIFNIAAFVFVGAWMPFKDFSNETLTLSVWRLLVIGILVLILRRLPIIVGLYKFIPDVKTFREAVFSGHFGPMGIGAVFISTLAAQQLPVPENPPVGQQQMLAASIQPIVAFMVLCSIAVHGLSIPFFTFGRRVHSVSRTWSRHDTFGTFGSTRRRSIIPEWTTQIRHVQPGEEIIINRDGQAESITPVDGSETQEKPIDEESPPSHEKPVPAPDNPPDGDEQVQEWKEGPHRVIERRSAPGAEVEVEVQRNVYGPSETHTATLRIAEDASRHAVDEIRGKLRNAPHEMEHILRSAEEGIRHEAKDMEQRVKRAGDALGDALSPQTSPPDSQRRQEREGQGRARGTDEESPEDEGWMSDRSAGEPSGSGNRAAGRGPEKSRKSKSPKIKAPKTKSKRAFAGMRHSILGQRPNALHRSRSEEYDHTRRHSQSFTDGNEDLPQGAQTPSEEMRGRSSAVRSPRSPRSPASGTATPIGPHPHLRLAHRRVDSIRSELPSREMSPARSVRFVDDGRGGASTPRIVSPTSPNTPSHGMSEAEGESGQNGDDDEESPRTTVRFSLPGPEAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6Y6</accession>
    <name>A0A4V2K6Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_936783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145198">
        <property type="protein sequence ID" value="TBU54058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6Y6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="21668" checksum="ADB7C67621E3DC32" modified="2019-07-31" version="1">MHVKIWSPNTCVLCPESPSDARVAVVYVFCNLRPLPHANRPFAGHLCSEPCLTSTGSVGAMSTSCPIYRPSVRGPHCSCSPPAIPDRRSVAKTYHTLIMPSSHRVFIACSSDVAVLPSPSTSSHLPTSHADQNPIPTANTNCELRAPSQTKQPRSRKKTPSSWTAAMPPSAHVEHTSRASTTGALRRSGSRQSSQSSSASTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7E0</accession>
    <name>A0A4V2K7E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_979327</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7E0"/>
    <dbReference type="STRING" id="114155.A0A4V2K7E0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13662" checksum="3E97DE11818B898A" modified="2019-07-31" version="1">MVQAVTQVLDEQKMNYVATLLNRVRTGLYEIVEARGPFISRHNTNNSTAELYSYGPQVRVFLGCADATKPAPDRFVPGPFDTVDDILARMSDAGFDTIWLLSSHTIAAVVLVDPCIPGTGFESTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7J3</accession>
    <name>A0A4V2K7J3_9APHY</name>
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        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_823605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7J3"/>
    <dbReference type="STRING" id="114155.A0A4V2K7J3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="604"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="665" mass="73759" checksum="8B290075E506BD3D" modified="2019-07-31" version="1">MLERLRRPDGYSRNLPLARTRGSEYSTSHSHSRSYFYEKADAHVSPETSSESPSPRETRVTLPPLRQPTRSPMQSISFATTTSATSTWAMSPSAYSPSSTRSSSPVSRSRIQPREEYRAKIESEQGAAISPRDPDLDSWVIAQQKALAMIPPRPTPQVIHPRASISPDRHRSRAASPLWHPYPYPAAFTAERHAYRERQDSWSPEPDGWQYLPPLRNLQPSRAASPEFVQGSSSAVFSAPSRSPSPSPSVSSYSTNEASGRTDTDPTDEDDPVKVEPECIKLPPLRTMFPDAAPGWCTHHSWNGSERSSTSSVHRDALNPLSRSAVTLSTSAEYSARWRPRSPFRDDGDGDLPAQVSDLRSSISHETSNSPVTVSTRTQWRTQQGPASTRGRPAPVERIPSVGTAHTAELPVMSPTPKKYRFVTSKPVGTNAELREEELDERRRPVTVSPSGTKRRHPGTSSPSESSVDAPSPPETPEEEEDGPRKRRQGQGQLPYEGSFPAEPGSNARLVRSPRGAIVPAYHYDTERALKCAFPQCGAVLTGKKSETASHMRSHFLQAVEETLECPWPVEGEDGQKACCGMAFKDSANFGRHVSSKHIKAEEYQCNRCGRPFARRDAALRHMKTLCRVDGSGPKRKNEKRPKTKTEEFEEGEYREATTLQWLAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K819</accession>
    <name>A0A4V2K819_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_490462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K819"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17018" checksum="BDC33D40077C320D" modified="2019-07-31" version="1">MIGGAVEARVSHIFNNAARRVIRRDDGSGCPYGFHKACGPNDPLADGIRALDACRPPRALAPRAVSRSRQVHERCVRLPNHNTTYRSSLSPKPTNSLTPQASPQGPKHSPRRVSHSQVGGDPVGFTPRSTCSVFRTRRRARADKVSVCNGECTGVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8C4</accession>
    <name>A0A4V2K8C4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925047</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8C4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13160" checksum="B821BBD0ECA095D2" modified="2019-07-31" version="1">MLGSSTNTLSGSHPSSMTCTILASASPTIRARGGRGSMSCRVSCTGIGVSVCILIMDVCRLHGYGHRNWIDLTDSGDPSRSPFRGEQRPSHGYYCVYFLAVSLAKSSDTLQRQHKDSRYIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8D3</accession>
    <name>A0A4V2K8D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dbl-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_817152</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8D3"/>
    <dbReference type="STRING" id="114155.A0A4V2K8D3"/>
    <dbReference type="OMA" id="TTEGNPD"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1253"/>
            <end position="1278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="778"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1253"/>
            <end position="1264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1278" mass="146341" checksum="01F0CDFD576D5DE1" modified="2019-07-31" version="1">MYRAQSLQGPAASSSTWRDPDLLRTVQDLKRPLELHENYADEDDFYEEDPSEDGDDRFFNPALLSHIAVRLRDKVPRGTHVKGSIPYPRAFTGKDIVSTIQSQIQRELLVTHGISTNDRRAALQVARSLQSQLFFYEVEWVDRPLQDGVEDVYMFWDDQEGASDARIEREELPTAVITLLTRCYASSCDDDNPCYSYTCPRRRSALQLVAPTENEDEEEKDEWTRTVPPEILATIPDSEVNRQTIIHKLIHKEKQYLRDLDTIESLYIRPLRAANPPVIRPSEIDEFIDEVFGNVLDLRECNRHLLETIYVRQREQAPVIQCIGDIFLDAATQFRLAYPIYVGHLPVAEKRMKDELEKNAEFKRFVEQASRHPDAHKLDLKHFLSRPSEHLQKYPVLLEAICNETTDGNPDVEFLKEAIAAIKKLQTVAQLWTWQNAMGRGPTGKLEWHNLVPEDVRASLSKHEVKRQNIIFEVIKGEMDYVRDLENIEVMYVGPLREMDPPIIPRDRLEQFIQEVFHNYAELHAHHRRMLEKLHEIQRDEHPVIRSITAAIYDAVLNFREAYMEYIPNYPIAAYRIDDEMANNPQFKAFVDQCTRHPDAHRLDMKNFINRPIPRLLRYELLLKNILDETPEGHEDRDYIPQVLDVIKALGKETEPGVVSAKQKVEVWRYNSNLVFKKEEQIDMDLLNENRSLIHTGKLLRQPDTGFEWNGWTELFVLLFDNYLVMTKVKEKDGVTKYHVYRRPIPLDLLTLANFTDPPTQRGNSILRLGRSERHAGDAGTPTGAATSPETATDSRLVYPCTIHHNGRLGGLYTVFAESAQVRTEWKQKLEEAIGLRKVVQDSNKVFEIETLSADTFLVPSMMGNSNASWSHENAFTGKVTCSVPFTTADGRGLVAIGCAEGVWIGFRHDSRSLRRVLHLKMVTQCAMLEDFGIFLVLADKSLFAYHIEALVPSSPQSAHTTQTPQKLSGSKDVHFFSVGNLNGRTLVIYMKKKGLDSVFRVLEPVVGKINERSKAPQTFGSRLGLRSQRSEWFRVYRDFFLPSEAFDLIFLKAKIVILCTKGFEIMDLTDFKSVTIPQRDDPRLEKLAKRCESCRPMGMFRSSNDEFLLCYDEFGLYVDRHGDPSRSMGTIEWEGTAEHVAWHPPYVLLFDSRFIEIRHVETGRLAQIIHGNDVRCIWDGRGVTGVPPATPVPEGYGQETISQEPRVHGVMNATDVPTGPNSRVGRPVAQHVFELIPTIPLYLPGSLASPSQSTTYFSQNNSPPHSPRLNPALSWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8K5</accession>
    <name>A0A4V2K8K5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8K5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="9040" checksum="2541FC4F68A18710" modified="2019-07-31" version="1" fragment="single">MMCLLTKFVLERYQEHLNILCYRYQSGETILKPTRVTKIYRCLNLFRRLMRWQEPGGRLPTALAKNVSNLPVNPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9F9</accession>
    <name>A0A4V2K9F9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_915789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9F9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="19082" checksum="CD184FDEDA3D85FC" modified="2019-07-31" version="1">MNAPRLCNLAHRDRGRCVHGCALQDKCGQAQSRNRRVGSISGLSLTTLVLPSSVTATQVSIRWEYCLYSVLDTQTIPIQPILSVLASMGSRQAAGNFRTCSSYLVPLACYEVSYRRSFSECTAPRLAIAYLYIRHNALVVCPPSFCLPHHLYPSVMLFVRYLSEYPNFASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Y9</accession>
    <name>A0A4V2K9Y9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitotic checkpoint regulator, MAD2B-interacting-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_864844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9Y9"/>
    <dbReference type="STRING" id="114155.A0A4V2K9Y9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="423" mass="45158" checksum="F8ADB8FB377CD5FE" modified="2019-07-31" version="1">MLGVEGYGSDSDAGSDNESVPQVPLNSKGSSLTSQPSTYAKKSTFSLPPPVGAASSSKPSSGLALPPPKTKKVKKIAIGLPSLPKDGDEDNSDYDDRPAAKKPRLEFRAGASALLSMLPSPKNKAPVPAAPERVLGGGRGPGLVFKTAPSQSARTTTVEDAAEDAEDDAEQADPLDSSYSALLEERKEEDKPSLAFMPTSVKRGKANISVEEKHSAPISRPAVSSAPAVDFFSLGSSSQASSSKPAISTAPPVSSSAALPSFTAAPAVQDFQPPEPTPEDPYPGYYMLPSGQWAAHDPAYYQKFYDKWKKEYDAHVRALEKGKIKGFEGAEEQAEEVNALKEMERAKKEIQEREERKALTTAAADVPAAPKMNIKGAALGGRARSRHQLSTLLTEAYQNREDLEEKIAQGRRNRKEAGNKYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2KA04</accession>
    <name>A0A4V2KA04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Man1-Src1p-C-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_912357</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2KA04"/>
    <dbReference type="STRING" id="114155.A0A4V2KA04"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12935">
        <property type="entry name" value="LEM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1180">
        <property type="entry name" value="MAN1, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025856">
        <property type="entry name" value="HeH/LEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041885">
        <property type="entry name" value="MAN1_winged_helix_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12949">
        <property type="entry name" value="HeH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="HeH/LEM" evidence="9">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="8">
        <location>
            <begin position="371"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="827" mass="90881" checksum="D23CF4CC6440C088" modified="2019-07-31" version="1">MSRLTAAQIVAQGDYLKPDFDPASLTIAQLLGVFGHHNIRYPAQYNKSTLVRLWNEEIKPNAKRLLKERIKRENSQASEDGITDGITGRPLNEGKNPVRRSSRRLSKTPALEQVEPAPKPKRRRASAEPSLGGPSRRRAAQPVEPVLVEESEPEEEPVVRKVGRPKKAAADAGSQARRVSRPLTDEPESGWEDNNVFQSGTESSPLRPSPVRPRPRKSSAGARPAPKSRKSMSAPPQISPPSPPTDKGKERERLPSVKPPESDFEPKLPSAVFQARRLSVVRDLKEEDEDEVSPSAQPIASLADSLAEAGVEVPTDVEGVPEYERAASLDEESVDAVAQRIAEGGSLVTRDAQPDFPRPNWFLQLLVTLLLLTGSGIVVQYKQESAQIGFCDAGTSTNSILNGMREYRAAIESCNRENRTTLYVADATHTISPPPPRPTATALSADPDVSAIVAAEACPPPPLIPGVQPDECTPCPKHANCTADSIVCENGYILKPHPLLAFLPVPSVRKETANGVLQAYERPAHISSGSTFSELVYAAIHFVLDGAPYVGPVALPPRCVEDPRRKRHIGVLGKAIESILANERGRRVCEGLNFGLPEGDEATEAQRWGLEVEKLREHIKEKTPPHMLTTLDDTFNEAVGQLLQWGGVFMGEDATGKRFLAHKTPVMSWQCSARVKAREAWAEWRRSTIGSLVLILSILTVRRRQAKRAIEDEQVATLVTVALDSLRNQEFAHHTDPVMVPRPYLSSLQLRDLVLQDIHDVSKRKRLWSRVERVVEANANVRTNLQEVEGGDEQRVWEWVGSTGKTLPLETPGIRRLGFGEGGRVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MJI0</accession>
    <name>A0A4Q9MJI0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_52974</name>
        <name evidence="17" type="ORF">BD311DRAFT_417152</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
            <strain evidence="17">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ML143440">
        <property type="protein sequence ID" value="TBU26858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MJI0"/>
    <dbReference type="STRING" id="114155.A0A4Q9MJI0"/>
    <dbReference type="OMA" id="SKTKWHF"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001222">
        <property type="entry name" value="Serine/threonine-protein kinase ppk25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="363"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU26858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU62486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="640" mass="72329" checksum="57C5E976B5579B7D" modified="2019-07-31" version="1">MADDQPHKFPAYKLGEYTVVDEIAEGTFGKVKMAIHTVTGQKVAMKFISKHAIAKHRTKTRVQREVEYMRTLRHPHIIKLYEVISTPTDIIIVLEYAGGELFNYIVANGRMSEPQARRFFQQLISGIEYSHHLKIVHRDLKPENVLLDDDLNVKIADFGLSNEIKDGDFLKTSCGSPNYAAPEVIRGGLYTGPEIDVWSCGVILYVMLCGRLPFEDDDVQTLFTKISQGVYHLPSYLSHEAKGLINGMLAVDPVKRITIPEIMQHPFFTTDLPKYLSPLPQQGPVLGTLSSLVAPPKALEYDFIEGLGRIEEEVVDDLASRMEGVDKEDVWECLRRDDGPQGNAVKVAYMLLRDKRRAGRNLAEYEEQERDAKLAVMDPRHPLSPNAVSPGGTDLEENPFDSEFNDYDEDDEDLDFSTPQNESESNNFAVLNSSLPEQLPEPHHLQSYASAKKAWPAKEKKQHRTKWHFGIRSRSPPMEVMLEIYRTLKALGMEWKEKTDLGGLGASALLKEKRGSDRAKIERAREYDGYVDLRAASAIYFIETRARVQDVVVLMNLQLYMVDSINYLVDFHHKKTYKASLEPGAGKFDMAHPDCNLSETASESSRSIKDFNLRDEEVVSPFVFMDVACRLIIELAGGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MMD7</accession>
    <name>A0A4Q9MMD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_382434</name>
        <name evidence="14" type="ORF">BD311DRAFT_695422</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143425">
        <property type="protein sequence ID" value="TBU28028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145365">
        <property type="protein sequence ID" value="TBU51196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MMD7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MMD7"/>
    <dbReference type="OMA" id="HKKTRIN"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="16"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="13">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU28028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU51196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="14790" checksum="B84B4CBD89D8F1D6" modified="2019-07-31" version="1">MSGKGSGKSKSGKASADAAGKSQSRSAKAGLQFPVGRVHRLLKKGNYAQRVGAGAPVYLAAVLEYLAAEILELAGNAARDNKKQRIVPRHLQLAIRNDEELNKLLGDVVISQGGVVPHINPELLPSKTNKGRKSDASQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N1T3</accession>
    <name>A0A4Q9N1T3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_120360</name>
        <name evidence="8" type="ORF">BD311DRAFT_802072</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N1T3"/>
    <dbReference type="SMR" id="A0A4Q9N1T3"/>
    <dbReference type="STRING" id="114155.A0A4Q9N1T3"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052207">
        <property type="entry name" value="Max-like/E-box_TFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741">
        <property type="entry name" value="BASIC HELIX-LOOP-HELIX ZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15741:SF27">
        <property type="entry name" value="TRANSCRIPTION FACTOR AP-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU34460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="36681" checksum="689726957995490C" modified="2019-07-31" version="1">MDQHQQQPQPMQHDDSQNFVTAQYAMYPSSEDDTTGYLVYPQMQQPTYPPVVHHPGPPPRQISESDLQQAMQYHRSIHMMPQTQHFVPPAPGVYPAPSPHGVMPPSASPPPQSPNMYDPLSPPISGSDTSADGIYHSRNSSASGSPSSSRGNSLVHRHPLRYNPTPSPTSSSGRRSRGHSISDDDDRHPMGGVNMAESLANTRKEATRRQRIEAEQRRRDELRDGYARLKDVLPVSNQKSSKVSLLERATNHIVNLEKTNRSLQQRLAALEAEVTRLRSLNEKISLGVNNTPSPGQVNMDSRPLSPPPEGTQSQASGIDQPVGESSPSASESGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N3B7</accession>
    <name>A0A4Q9N3B7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_917359</name>
        <name evidence="4" type="ORF">BD311DRAFT_748688</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N3B7"/>
    <dbReference type="STRING" id="114155.A0A4Q9N3B7"/>
    <dbReference type="OMA" id="YFYKYYK"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.10:FF:000010">
        <property type="entry name" value="Acyl-CoA-binding domain-containing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="2"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11771" checksum="6C60707ED12643C9" modified="2019-07-31" version="1">MSKAKFDKAVAIVQSLPKEGPIQPSQEEQLYFYKYYKQATVGDVNTSRPGLLDFVGKAKWDAWKSVEGTSTEEAYAKYVEKLLEILKRADTEESKKYVAEIEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N6H8</accession>
    <name>A0A4Q9N6H8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">Pyruvate kinase</fullName>
            <ecNumber evidence="6 16">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_844436</name>
        <name evidence="19" type="ORF">BD311DRAFT_682339</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
            <strain evidence="19">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="6 16"/>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N6H8"/>
    <dbReference type="STRING" id="114155.A0A4Q9N6H8"/>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.20:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13 16" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 16 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="12 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="17">
        <location>
            <begin position="31"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="18">
        <location>
            <begin position="392"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU34496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU62064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="530" mass="58144" checksum="19F05014D0EF5B8E" modified="2019-07-31" version="1">MANPITSRVEWSASLDPTKAQVPTEETKYHRKTSIIATIGPNVNTVEKLAELRRAGVNIVRMNFSHGEYEYHQSVIDNTRKMVSLEPEGRPVAIALDTKGPEIRTGLTRDKRDWPIKAGHEFLLSTDDQYKNVCDDKVMYVDYKNLPKVTAPGKLVYVDDGILSLLVLAVEGDNVRVRALNNGNISSRKGVNLPKTDVDLPALSEKDKADLQFGVKNGVDMIFASFIRRAEDVRDIRRVLGPDGANIKIIVKIENEQGVANFDEILKETDGVMVARGDLGIEIPASQVFLAQKMMIAKCNKAGKPVIVATQMLESMTYNPRPTRAEVSDVANAVMDGADCVMLSGETAKGSYPIQSVLMMAETCLLAENAICYPALYDELRDITSRPTETVETVALAAVAAASEQNASAIVVLSTSGNTARLISKYRPSVPIITVTRNQQTARQIHLHRGCYPFWYPEPRGIEAHQWQTDVDNRIRFGLRNALALNIIKTGTTIVAVQGWKGGLGHTNTLRILSVPTDPADLAQQPLGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9Q9</accession>
    <name>A0A4Q9N9Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_910742</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145342">
        <property type="protein sequence ID" value="TBU51301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9Q9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="296" mass="32791" checksum="85A652CB9C7F4901" modified="2019-07-31" version="1" fragment="single">LIALSLIPLVLQHERIRTPFRITWESVSAAFDGWKLESTPTVEFDWDGEAPIAFCFSRYNGLAQQSTLWFVLGVCDLAEPRQHFARFYVHLSHASAPSPDQYLTHNWRDSHGRPDGSYTWYDRSGKISLSFTPCPVYDTSVLVLGQWKEPVNPRAYSQRSLISHIGCMKMLSTFTGEGAFSIAMAQNVVADHDISIEELVDLATESTPSQASFSNPAFASFPLPVMLHLSEVVYVDLNSTGDAMDGHGNGNPVESISGSVFSQPRIMQSLGGYEQRNHAVGGNLQNVGHMLKHVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NF35</accession>
    <name>A0A4Q9NF35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vps5 C terminal like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_618315</name>
        <name evidence="3" type="ORF">BD311DRAFT_749301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NF35"/>
    <dbReference type="STRING" id="114155.A0A4Q9NF35"/>
    <dbReference type="OrthoDB" id="9976382at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030905">
        <property type="term" value="C:retromer, tubulation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07596">
        <property type="entry name" value="BAR_SNX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06891">
        <property type="entry name" value="PX_Vps17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053055">
        <property type="entry name" value="VPS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037907">
        <property type="entry name" value="Vps17_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015404">
        <property type="entry name" value="Vps5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47433:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09325">
        <property type="entry name" value="Vps5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="82"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="649"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="709" mass="76557" checksum="96301D10B35B75BC" modified="2019-07-31" version="1">MSMFDPLSVPNFPQDEPPWPTTPHMPNEPIPNLPRPSPHHQDSRGPPTGLYGREPQIYGQPEPGLISPRATTSSTGQPLEKKEPYLRVRITSLDRNRRDVLIKFDAQTNLSNFTGTTYRNVSRSYLEFQQFYEAIIQNNPQTIVPALPLARTSAPTDEEDDRLVKIMLQRWLTRICEDPILIHEEELRSFIESDFGYQPTPNTRKKASGGFSLIRRGVPDEDEELQRARFELTKLEGQFFDSAKAIDKLARARKSIAVVKAEMGNKLLSVSTAEAHPPLGNALAKIGRVYHSLADLDQAQGISECVIIGDSLGYQGLNARSAKETLQQRTGVLEEYQAAVKATISKRRNMERLKASNNISPQRVDEALEEMEEANKYEQILARRAEGISQNLHRALDRHRRLVTEDVTAALVEHVRSTIMYERQHLRELEALRPDVANADKKHVPQKPVSTPRPTYIPPLEEFSKPAIPRPASGPPSNAPRPPSQNVPAPISATSSMIGSPSGGRPPISVAVSTNGSSHGPLSPGSVSSPLRAPLSPQSPGAGPSSSSSPVPSQSSFAPPLINGPPLGGRFVDGTKSMFVKSPSSPLAATGSTPTKPASAGLPPVPSSAVTQSTPVSPLHGTVSGPPSSVPSPAPHPLARAGDPLSASMFVTSSNPPANGRSNSVSASSDGLDPLGMAKPAYMSASVRVQPTRPRLDAREAASKLANMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFE6</accession>
    <name>A0A4Q9NFE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_815488</name>
        <name evidence="7" type="ORF">BD311DRAFT_191616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ML143583">
        <property type="protein sequence ID" value="TBU21706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFE6"/>
    <dbReference type="OrthoDB" id="2861623at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01020">
        <property type="entry name" value="Terpene_Cyclase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU21706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU60351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="341" mass="38888" checksum="3FAE3B23BACDD7B0" modified="2019-07-31" version="1">MTVASPPPSSYRPTSIIFPDLISPCPYPLRVNPHCQLASTESKRWLLQGCRLKKKKRAAFHGLRGGLLTAMCYPLADYEQLRVCCDFINYLFHLDNICDEMDDRRTVSTSSEIIGALRDPRGFRASSAVGRLTQSFWRRLTTTGSQGAQRRFIETFELFFRAVTQQAKDRASGNIPDLESYIAMRRDTSGCKPCWALIEYANNLDLPDWVMEHPVVLGLGEAANDLVTWSNDIFSYNVEQANGDTHNMIVIVQHHEKLELQEAIDYVGDLCLGCIDRFDALRKALPSWGPEIDEQLNVYIDGLSDWMIGNLVWSFETERYFGKEGPQVRRDLCVRLLPLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFQ3</accession>
    <name>A0A4Q9NFQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_834376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145323">
        <property type="protein sequence ID" value="TBU51425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFQ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26683" checksum="7EAF81DD6CF38C22" modified="2019-07-31" version="1" fragment="single">VDLRITCLGDDLFGPIGWSYDSNTGLLGGMYGGTPYGFAASVLSLCVNMFATIIVAYKAWCCRKSRWFLRKFMVSGDRNTRVERLFSILIETGMVYCAIWILVVVWQCFFYVPKNSITFQDRFGNFINTGLVPIIAIYPAVMIILVAQNRSHIEKAFGGRAVSTPKPSRWDGIRAPSATVLHIARQGGEVGEESEESSTHTADERKLESGGTAYYVVHVAAQGPGDDVDATDISQGERGVSSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGQ9</accession>
    <name>A0A4Q9NGQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_977886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGQ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="187" mass="19148" checksum="4BFE7E5F5AEA8FB3" modified="2019-07-31" version="1">MPSMHIDDFGHNHGLHVVIPTTEAGSRVPSATASNASDGPTALDTPGHNHNLSRLPAPASAPQSARALDTPGHNHNLGFRWPPSAAAAAASAAGDEATATPTTPRVSARVSRRSSLFSVADDSEAKTGAGSLFSVENGLGEVVGHTHVVLPPTSEAEEPVTAELQGSFQQQMHEDGDGDDRAVEGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGU7</accession>
    <name>A0A4Q9NGU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin depolymerizing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_918023</name>
        <name evidence="7" type="ORF">BD311DRAFT_697544</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143438">
        <property type="protein sequence ID" value="TBU26989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGU7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NGU7"/>
    <dbReference type="OMA" id="WIGPNCK"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11282">
        <property type="entry name" value="ADF_coactosin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU26989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="144" mass="16228" checksum="0A3310A4E0DA9CC2" modified="2019-07-31" version="1">MADVSDPKIDEAYQDVRSDKTETNWLLLDYESDRSDKLKLTSTGSGGLAELREQLDDSKASYAYVRVQYSNDKESVREKFILVVWIGPNCKVMRKAKISVHSADVKSVLRVFSIEVPAREKDDLKEEPIIIKLRKAGGASYDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLA2</accession>
    <name>A0A4Q9NLA2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">adenine phosphoribosyltransferase</fullName>
            <ecNumber evidence="6">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_446873</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="6"/>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLA2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NLA2"/>
    <dbReference type="OMA" id="ITHFVYH"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002055">
        <property type="term" value="F:adenine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000021">
        <property type="entry name" value="Adenine phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050054">
        <property type="entry name" value="UPRTase/APRTase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002634">
        <property type="entry name" value="PRK02304.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002636">
        <property type="entry name" value="PRK02304.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32315:SF3">
        <property type="entry name" value="ADENINE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20053" checksum="75A2695A676F55C0" modified="2019-07-31" version="1">MADVEYLRSLLRPFPDWPKKGIVFLDIFPLLRDPVGFETLITHFVHRLTSHTIGQSPTKKIDVVVGLDARGFLLGPIIAMRLGAAFVPVRKKGKLPGETVHAEYEKEYGVDVFEMQADAIQSGQNVVIIDDLIATGGSAKAAGELVAKLGGKTLEYLFIIELTFLKAASKLDAPMYSIVKVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NP41</accession>
    <name>A0A4Q9NP41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_804864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NP41"/>
    <dbReference type="STRING" id="114155.A0A4Q9NP41"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="534" mass="60380" checksum="A0724F3EB7C8160A" modified="2019-07-31" version="1">MPPPPVPVRSVQAKALPRIQKKWKWTGDLFMDVSRNRAERVCEVLISEATDPLPNGLRFSICLSGENIRLSAFHELSCLHTFLLASTRVQQFAKLGSASDKDADALLQLGIFMQKRSYFCFAHLYMDDSSVGLLIIFPTGHEVANSLLKVPPTLASNTPLQVALVPWELTTREFRAANWKSRSPIVEHQLDPAFAAILEADGRSVATQRRFYQALHILTFPKAIYDFMSQKQSPRPYCIWYAPADTTQSGTIGYETLLLREILSTCTQAKDMGYKADVRVVFVHVGALATLHGLPFLVAWRNKRPELRFLTYGTHPSVPRERWGVREIYLIGGVVTFTPSAIIEGHGMLFRRIKDIAEHPLWDCYVLPSVVAMVAKLTCQGGHPLRVYDEGNFVYEDLLKAIEQGSVALLHAPAILRDAPPKGDPSLLWTRWMLRLPSMNARQILEECLRIAAEQFANTSDAELPVAVEKEIARDLLRMQMQPVMMDNYRRFVVLKGRSDTDFQEDRCPGIEVTTLSKLDFRDDFFTTRTDSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTS6</accession>
    <name>A0A4Q9NTS6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetylornithine transaminase</fullName>
            <ecNumber evidence="5">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_915578</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="5"/>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTS6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NTS6"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="492" mass="52333" checksum="F699651AAEE6D691" modified="2019-07-31" version="1">MRAITRQAPRTLARSAKRALGARCMATQVMGDVPLPDKPSTRYTAVTHPEDPASITPKVKEIIDRSNAYILPVYARPPVVLAKGKGAYVWDVNGREYLDFSAGIAVNALGHGDEGLVEVLKTHAGTLLHTSNVYHHEQAGKLAELLITLTQKEGGLGFAPGSSHALTDGTSGAKVFFSNSGTEANEGALKVARKVGKARWAAATGKPEDDPSCDKIEIVCFANAFHGRTMGALSVTSNPKYQKPFTPLIPGVRVGHLNDAVGLESLVGEKTCAVIVEPIQGEGGIHAADVNWLRALRKRCDEVGAVLIYDEIQCGLYRTGSLWAHSGVPIDGHPDIVTTAKPLANGYPIGAVLMRDEIAKVMTAGTHGTTFGGSPLACALGYHVLSRLSDEAFTANVKETGAYLRARLEFLAQWFPDILEEQVRGRGLILGLGFKDKSHPARVVELARERGVLLLTAGSDAVRIVPSLNIGAGEVGHAMDVLASCLEVLSTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUA2</accession>
    <name>A0A4Q9NUA2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_830667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145223">
        <property type="protein sequence ID" value="TBU53162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUA2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NUA2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="32111" checksum="E2957D018E44A2BE" modified="2019-07-31" version="1">MASHLLTQSLSALPSATSPTLLQGEDPKGKGRAVSSSYPSTSSAAAEHPRGEGEGEKDAVPTPPPRRAHATRLATGALSTPPNAYKEPSLRSAAAGGSGLGDTEHASGGTADGKSKDKAKAETGAGSPAVLSVLKDCRIFVDVRSEEGDDAGSLFVDMLRNMGAKIAARVGSRCTHVVFKNGLMSTLKGYRMLSDPKPHVVGIGWVVACAEQRRRVEETQFPVNLNLANVAGVNKRRKSVIPKTYSPMANKIATSPASSDSSRIDNVLNTSLGAASRSLEVSSPGVVNEESLPPLEMARRRRSMMPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV95</accession>
    <name>A0A4Q9NV95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_905905</name>
        <name evidence="9" type="ORF">BD311DRAFT_741933</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the oxidative stress response and detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 12">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ML143485">
        <property type="protein sequence ID" value="TBU24196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV95"/>
    <dbReference type="STRING" id="114155.A0A4Q9NV95"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000016">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU24196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="221" mass="25461" checksum="B0DC8EDEAD63D2D4" modified="2019-07-31" version="1">MSHGKQFTLYTHAGGPNGWKVVNVLEELGLTYEPIYLDFGKNEQKAPEYTKYNPNGRIPTIIDHKNGDFVLWESDAILLYLTDKYDTEKRLTVTDEKEKYSLIQWLFFQSSGQGPYFGQAAWFLRYHPEQVPSATERYRKETLRVISVLESVLSKQEWLVGGKPTIADFSFITWTNVALGFTLKDYADVEKDYPAFFAWHQKLVSRDSVKKALATQAALNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVC3</accession>
    <name>A0A4Q9NVC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative methyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVC3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NVC3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF109">
        <property type="entry name" value="RIBOSOMAL LYSINE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="263" mass="29362" checksum="8C66BB51E088D212" modified="2019-07-31" version="1">MHKSHASRRPRRKVQGRKHDVSETLEVEIFQDKTALRSRKGDTGSVVWHASVDFAEVILQQLRNRSPHGFFTPEGLAQAHVVELGAGTGLLGVLLSPFVHQYTITDIEDLVPLIRKNVTRNLPIPLTSPPEPKHSPPKSPIPNVVTMALDWIQLHNAPASLRPRLVPSDPADILLVVDCIYHPSLLPAMLTTIDYLAVPDKTAVVVVVELRAEDVIREFLQGWLDKSSSQGEWEIWSVGELLEGPYAVWVGWKTALSQSERQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVY5</accession>
    <name>A0A4Q9NVY5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_927913</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVY5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NVY5"/>
    <dbReference type="OMA" id="GHDVVMC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="552" mass="59632" checksum="A852F97C406F0379" modified="2019-07-31" version="1">MKLLALVSLFAAVYSPVAALWPQPRTINTGNNTLRLAPNFQIIVSGHGVPSDVQAAVGRTQSYLAKDKLARLVVGRGASDAKSFAQAKTLSKLTVSLEKGAAWKPITSEAQKAPADRDEAYHLTVPADGSAATLTANSTLGLLRGLTTFGQLWYAYDGTTYAIETPVTIEDSPAYPYRGFMLDTARNFFPVADIKRTLDAMSWVKLNQFHWHVVDSQSFPLEIPGFTDLAAKGAYSSSQVYSPSDVQDIVAYAGARGIDVMVEIDTPGHTAIIAEAHPDFVACPGATPWGTYANEPPAGQLRLANSTVTNYIADLFTAASELFPSTLFSTGGDELNTACYDIDEPTQAALNATGSTLEQALDQFTQVTHKALEVKGKTPAVWEEMVLVHNVTISKESPVLVWISSENVKAVAEKGFKIIHAASDYFYLDCGHGAWVGDFPTGNSWCDPFKSWQLSYSFNPTANLTTDEAALILGGQHLLWAEQSGPENLDDTIWPRAASSAELFWTGPGGNISTALPRLHDVSYRFRTRGVKTISLQPEWCALRPGACDLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NX28</accession>
    <name>A0A4Q9NX28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_472367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NX28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14346" checksum="A6F29FDB16D02E16" modified="2019-07-31" version="1">MCSRGHCSGAAAGWTRQDRRGQGATEAGRWRTRGRGALSAGGGVSSPRAQFWMRGYRHLPRQNSEWDNILVALPSFLLLLSPSPSQAQICAQPTCLVSHYISSVLCGHSPSPFLIFRRASPAQPLLSNLSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1Z6</accession>
    <name>A0A4Q9P1Z6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_848024</name>
        <name evidence="3" type="ORF">BD311DRAFT_866089</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143432">
        <property type="protein sequence ID" value="TBU27429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1Z6"/>
    <dbReference type="OrthoDB" id="2131701at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23422">
        <property type="entry name" value="beta-trefoil_Ricin_MPL_CNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="2">
        <location>
            <begin position="41"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU27429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="152" mass="17051" checksum="B84EE057B5AFBE7D" modified="2019-07-31" version="1">MTVQIKPSHTYRFIHAKSRAVLDLSMADFKSVAAGTWADSDNQKWVAERARSVPETGATRWTFRNVATGLYLGIDGAPRSAARVAATRTETEWDVRPDREDPAALRVVVPTARLALQLGDKGIPQQGAPAMLWENRDGEDQRWQLEEDKRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6J6</accession>
    <name>A0A4Q9P6J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_840247</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6J6"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6J6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU64047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="215" mass="24140" checksum="F1713BDD0B90915F" modified="2019-07-31" version="1">MKFATEEELAGHHAATVRGAIEGTLGSLAVTLPATWYLNRRWPAFRALPPQLKALGIVLIVAPCYAIQTERRGVEYDESTWTGAAKAMLDDNERKEESRWESLTNGQKMKDWAMRNQYKIILGSWAASMAIAGTIVMRNRYQSTPQKIVQARMWAQGLTIGVLIAAGVLTQTQRQQAHDNRSVDHSWAAILEEQQKEEQEIQLHLTQAKPQTQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8W7</accession>
    <name>A0A4Q9P8W7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial ribosomal protein subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_911323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8W7"/>
    <dbReference type="STRING" id="114155.A0A4Q9P8W7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016712">
        <property type="entry name" value="Rbsml_bS1m-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28058:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11709">
        <property type="entry name" value="Mit_ribos_Mrp51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="45090" checksum="0F84EA6DD1AD3DCB" modified="2019-07-31" version="1">MATPPPSQFAALLRRSKFASYDPHIGQVYTAFDGHAARGNFGLKRPLALRRRNAHITVQAVDSREQQTVWRSAEQENRWIRMWDEVGVRPKLENLTKWEQKVGTLGAEVSFLADSEFVHQEAVEAQKEDGLYEELAEEEEEELVKKSYAVPNLDAMSEKEFEQYLEHLRSLRPAFHNFLRKKYKNHPISSKTLFQHSLRGGDDFREFLESHAYQEYHKKHPRYIEQQPHRYAGLSYSHAPDVQTFNTTKPHVGRILGDLGTDRQAQFYAVASAGMTSRLTVGSKGEEGNQIITLRFTGATLASTPEVVGARPEGLEGASLRTSVRVDGPTVPYKSGTNPHPPGTREYVAYLEKKQRDHSVSMTSQPRPKQVDFTPQDHNIPAQRLLNVLHNMSFKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P997</accession>
    <name>A0A4Q9P997_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_982818</name>
        <name evidence="9" type="ORF">BD310DRAFT_982820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145364">
        <property type="protein sequence ID" value="TBU51198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145364">
        <property type="protein sequence ID" value="TBU51200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P997"/>
    <dbReference type="STRING" id="114155.A0A4Q9P997"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="507"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="528"/>
            <end position="535"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU51198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU51200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="958" mass="108587" checksum="A9DBF79BD079EF35" modified="2019-07-31" version="1">MSKQSKSKDPSSKGRAVGQAVVELFDKMSLHGDAAVDIAVVKLDHLLADPSIDIDEVVELMTSVQHLLEFVLCVSSDYGFGILSIAILQRQPSTAEDYPSSLLYKLLAQLSRSLCLPYERTSDTPPVLSAHRRSIELAFSVLQAVTHLNATDALAEQMGDDPGSGRWAAKNEEKRHQKRKRSIHTGRAPPVDIVKSIIQYGAPVPTSKRQAAELVTTVVAEQTSILQEVFNMFRKEETIAFFKTTYLPIPPAPTPLTVTIPTQRTRSATTALTPFVPMTGTQQGAFPLVQPIKAALYFENADGFGAWRIQMSTRADRDLRRWRNEDAKMFDIIVNKIKDLSHGNFTKDNHKKLTGVEVDIPIYEAKMTRDSRLVYHIHCDIDFEDNVERQGLIRIFGVYTHAQIDGRFWDTMSRQLGYNGSEYRRRCIFRDRPSNQRGDYTVLPASFEVRSDTEQEVVTPSSSTTDHPDLTREDKEELHSLIALEKFVTFSQAFLNSILADQDVAHVFGVSHREKEIIEHDSSCFVIGRSGTGKTTTMVFKILGIERTYDTGSFRYAMAKPRQLFVTQSQVLAKKVEEYYAKLHQSYATAHLSPDELLEIASQSRTRRERMVDEDEEIFYTSTLPRRFGALEDTHFPLFLTYNHLCRLLENEFRHLVEQEKIDAHRASLLRDIMKLRPRPTRTRPAAYLQEERDTFLDYDTFREIYWSHFPENPLNPDLVWGEFVAVIKGSAGALKSDLGYLDKETYVGHGHSRSQTVSPAQRETVYALFEVYTKRRKLHGHHDPADRTRMLIRCLKAAGVPGKALNFIYVDEAQDNFLIDSLVLKALCSNPHGLFWAGDTAQTIAAGSSFRLGDLKAQLYDVEKNPLSISKRARPQTFYLTRNYRSHSGIVDCAHSIVELITNYWSTAIDDLPRERGMSPGEKPIFFSDHDAAKLQQSLFRDVSGGGVIEFGARQCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9V5</accession>
    <name>A0A4Q9P9V5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_963078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145325">
        <property type="protein sequence ID" value="TBU51414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9V5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8747" checksum="555F59D7E87F4E23" modified="2019-07-31" version="1">MEHVVELHQENITYLYRYLEYLTKYLKYPKYLKYPKSNGLGQVGWVNLAKYQVLGQVLQVPVQVHAQVHCEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA74</accession>
    <name>A0A4Q9PA74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_834031</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145305">
        <property type="protein sequence ID" value="TBU51579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA74"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6947" checksum="A36B9C5AEBCC8D04" modified="2019-07-31" version="1" fragment="single">HTNGVQQLTGPTVQISLSFVALPDRDLQVFRFLRRAAFKESCDFRATLSGNLAERSVNKTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBJ0</accession>
    <name>A0A4Q9PBJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_276842</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145279">
        <property type="protein sequence ID" value="TBU51878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBJ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="63" mass="7435" checksum="A44BB7755B6FC538" modified="2019-07-31" version="1">MDILTLVHLLDIELDCRLEVKGMHTRTHDQTVFFMHIHPRQLDNEDLCRTLTLPSKPETSDTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCC7</accession>
    <name>A0A4Q9PCC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_941803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145294">
        <property type="protein sequence ID" value="TBU51685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="649" mass="66328" checksum="1C1705EFFA50AAEF" modified="2019-07-31" version="1">MMADVLAQGAQAVPIELLLKTTLRALGALGTLLDGCVAACSTDVSRSRLGSSADASSGAGSRFRHESGFASVSTGSSAAASGVRHPLAALSLVDSTLHRLIPAVFSSLSAHAKKGKAAAKTASAVDEVLGWVYALVLNPLVLAFAPVSGSFLSACLRPQSKSNSSSRVSYGGNSPLSRLPAAIARGGTDLRPTILDLLDKTLSALEAQSVAIARGSSAAAAGAGTNLAHGRRGGNGTSNPNPNRESATDLGAHAISGVCAVKRLLALVCVRELERMYAPLSCAYSHGRDAELATTPDARSSSSSDAALGNTCNTIGNTRPSSGREARHSLPRDLLLALLPGSAYAYAHGLGGGSGTSEDPTRPGTAAVGPSSPDQLPLPQSQSRASATGWAYGTPRSLGALARAAGNLGETRVGGSSGGGRGPVCEEAVRRASGASSGFGLEFTSTPRAGFWDQDRLARVAAAAAGATAGAAAATGDDDLRADALDDKTRERMTWLARKDAAWYLCAALNRLLPCSAAALSPAQTAAASYSSSTPRPEPTDTVAEQAVYAALADLLRRTRPSTVAAFPDLASGPSADGKETLDTPFHEDPAADRDVTQDAETHGHGNGSERTEDDRHERMQTQTAGTMVMGEVERTMLLAVLERAWLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDH3</accession>
    <name>A0A4Q9PDH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_952545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145239">
        <property type="protein sequence ID" value="TBU52718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020388091" evidence="5">
        <location>
            <begin position="21"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="109"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="309" mass="33158" checksum="2DF08E41556E9EC6" modified="2019-07-31" version="1">MAPCFLLGGALLFALHAVLAVPAAPSLPRQEADATDGIAPLAQPQIESFKPYTNFANAAYCAPIVTVDWSCGQHCEANPNFKPTAAGGDGIFVQFWFVGFDPDLGEVIVAHQGTQLLTIVPVLEDLDLLPLPLDEQLFPGVGLDVLVHSGFSIAQAETSQFILAAVKNTMQEFNTSKVTTVGHSLGASISLLDAVFLHLHLPDATVRFVGYGLPRVGDDPFVQLVDRLGFQVNHVANKKDLVPILPPVLLGYRHISGEIHIDEANQWINCPGHDNPSTSCTVGDTNLLLDFNIFDHAGPYDGVLISTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDV8</accession>
    <name>A0A4Q9PDV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_244786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145258">
        <property type="protein sequence ID" value="TBU52275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDV8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="12140" checksum="7EB9F82A4F7BC7C6" modified="2019-07-31" version="1">MFLLDGGNLMFGLAQTYPLAKSHHNAETAKQALNNVEPHLKALDGVILRVLRDTSLKILDDGARRRKERKRDHIPQERFSELATERRRPCWEGDGRHSINDRDAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF60</accession>
    <name>A0A4Q9PF60_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1001082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145281">
        <property type="protein sequence ID" value="TBU51847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF60"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF60"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="753" mass="85679" checksum="E5598574E23F5ECD" modified="2019-07-31" version="1">MRPSFAPRSRPANGRSLGSIRACLWSSPVISPEAILSTIHSSTTSTYGIMKEQRQRVFKHLTEIADLLFAAQQRVFLFMLVVMGRSSRVLRWDRSGLVVTPSFDYYERPGLLRDYLWRLSNMGPSALGFDPSATRVLPGDGDFVRMDSAALQNSNDADHTERDLTDEVQEPSTFAYVRAMFRASLASDWPRYRLQVPDGKENRSFLVGKPVFRADGVLGRGTRGYVALDCETNLFVWLKDTWRAAYMIAQREWDVLQKLNQAGVEYIPTLVCHGDILDKSTVTADCWEDTRALPSTGKRKREEDIGDDTSHRRFEAKLPPDPVAHSGRPLRPHNHYRIVVEEVAIPLKKFRNGRQLAAVVFDAIPHYQASTKPTTPVLHRDIISGNILIYPKVRCIEDGTRLAMVWTGLLVDWELSKPIDDHEASAQATQAERMGTHQFTSVNLLTRPWSPVKISDELESFFHVLAYNSVLYLRSNCDCRSSYIDNYFNDYSGPARAHTCGWKSFAVEIDNWLCTQVPYRSRLLFDSPMDELLGEIHKCLKAHYKSLNYDLLQAAPPRPKVIHPPISAALKFRPAISIARIRIPDEVRKRLKSKSPRLLTTPRRPRIGNERNRSWTISSSWSTLLGCSGARNGLKTIVSIRLRNALLRRPMRARACLLQLQRSRVTSVGGPPVHRQSVRFTRCTPVATCPSQVVVRMWTSGEVEDHTAVGSGVFRWNDFLFLYNPRSSRMNAVCLRYVPRRCCRVGKICMWSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF91</accession>
    <name>A0A4Q9PF91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histone-fold-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_887372</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145208">
        <property type="protein sequence ID" value="TBU53640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF91"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23645">
        <property type="entry name" value="HFD_Dpb3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF54">
        <property type="entry name" value="CHROMATIN ACCESSIBILITY COMPLEX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="4">
        <location>
            <begin position="62"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="144"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22753" checksum="283D5AA6390CB076" modified="2019-07-31" version="1">MATSPERPQQLVAEEDPAPIEMEPAAEDSQPTGETSTENAKPKKAKSSASEPLKREPGKSLFPYSRIQKILKEDTELIMVQREAVLAISRATEEFVARLAEACQRAAARDGRATVQHKDLVTCVRRADEFAFLEDLLPWIEPESASTTKQGKRKSGRTKDETSKDKKAPTTLDQFVRSGKDDSQEPPGEVLVNEDGTLSGGGPSEETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFW0</accession>
    <name>A0A4Q9PFW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nitroreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_941309</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the nitroreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145277">
        <property type="protein sequence ID" value="TBU51902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFW0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFW0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02140">
        <property type="entry name" value="Frm2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.109.10:FF:000001">
        <property type="entry name" value="Nitroreductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="entry name" value="NADH Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033877">
        <property type="entry name" value="Frm2/Hbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43035:SF1">
        <property type="entry name" value="FATTY ACID REPRESSION MUTANT PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="FMN-dependent nitroreductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="286" mass="31634" checksum="62106E679EA616C1" modified="2019-07-31" version="1">MYDDPSGISQGFLPDQGPRQDLSQITPSAFKMMSGISSIPSIYNRTSRSLLSLTQRRLVSPINASSLSPSRLAFSHSQYRTNMSGSAAFFEAVRNRRSVYTITSETTIPDEKIQEIITEAVKHAPSSFNSQSSRAVLLLGAEHKKLWEITLNVLKGIVPAEQLPATEGRIQGFANGHGTVLFFEDETAVTELQTKFPLYQDRFPQWSQHASGILQYIVWTALEAEGLGASLQHYNPLITPQVLSTWDLPSSWTLVAQLVFGKPSAPAGEKTFQPIEGVRFKTFGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG31</accession>
    <name>A0A4Q9PG31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_766333</name>
        <name evidence="17" type="ORF">BD311DRAFT_605270</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
            <strain evidence="17">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143457">
        <property type="protein sequence ID" value="TBU25673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145271">
        <property type="protein sequence ID" value="TBU52022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG31"/>
    <dbReference type="STRING" id="114155.A0A4Q9PG31"/>
    <dbReference type="OMA" id="EQTVEYV"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000044">
        <property type="entry name" value="Probable U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="16">
        <location>
            <begin position="3"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU25673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU52022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8174" checksum="D51BD0CCF3B72DC7" modified="2019-07-31" version="1" fragment="single">SGSPTDFLKGVVGKRVVVRLTSGVDYRGILSCLDGYMNIALEQTEEHVNGRVTNRYGDAFIRGNNVLYISAAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG80</accession>
    <name>A0A4Q9PG80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG80"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="399" mass="42784" checksum="38C3049E92C92E13" modified="2019-07-31" version="1">MDVLGAGARSSGHPTVAIRLALSTLSLFIVTTTSLLVNVTVDDTFGDPTTGFIPQYLPNEPSGTIGAWHSGNPSETDDWSTSHWTPGVLDVFEIYNQTWHDSTPQNGPAQVVVNFTGTAVYVYNVVPNTVTKTTTKTNMTFSIDGKVLDNFTHPPDETGIILYNQLVFSITELPPSPHTLVISAEGEGQSFICFDYLLYTTDADKAASETQSSKYSTSSTTASTVFVTTTMSPSSRAPLDTVLGAVFGGVIVLIGIALGVYFLLRRRSRYLSSITNPTPFNPHHESERSDYGAQDGAGPSSPMTSALTGTSTEALMNRYIHYLATRPDMPTSDAPGTSEWKGSQQESSMYGVPKARTISFDTSAAGTETVFGALETEVAALSRELSGFQMDAKGETTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHP7</accession>
    <name>A0A4Q9PHP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_830157</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145215">
        <property type="protein sequence ID" value="TBU53417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHP7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6410" checksum="AF7EF6C7584F5D3C" modified="2019-07-31" version="1" fragment="single">RSDPLGSDPGSSQGNINVGACGHVNRRVGRPFATHCSSELACSGHELFFPTAHWQRLGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI45</accession>
    <name>A0A4Q9PI45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_130822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI45"/>
    <dbReference type="STRING" id="114155.A0A4Q9PI45"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21608">
        <property type="entry name" value="RRM2_NsCP33_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000634">
        <property type="entry name" value="Related to glycine-rich RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048289">
        <property type="entry name" value="RRM2_NsCP33-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF56">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN A0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="3"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11045" checksum="F5DC46D6139DBDDE" modified="2019-07-31" version="1">MSTKVYVGNLSWNTTDDNLRNAFSTYGQILDSIVMRDRDTGRSRGFGFVTFSSGSEAQSAIASLNEQELDGRRIKVNLANARGSGGGGGGEMIFTWRSDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKC1</accession>
    <name>A0A4Q9PKC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKC1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF7">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="347" mass="37974" checksum="EB3D9D8DB48E775B" modified="2019-07-31" version="1">MAPVTNGRVLFNEYLPTGYPIPGKTVVYDTSETIDLENVALNGGFLVKVLVLSIDPYQRNRLKAPSDQRSYGSFELGKPIQNFGVGVVLRSENSAVKAGDHVYGQYDFQQYVIVPELPSRIWRVLENKEQIPWSAYVGVAGMPGQTAYYGWKEYASPQKGEVAFVTTGAGPVGATVIQLAKADGLKVIASAGSDDKVEYMKSIGADVAFNYKTTKTSDVLAKEGPIHVFWDNVGGESFEAAIEHAATGARLLECGMITVYNTNETYTVKNLFQIIGKELHVHGVMVAGPLHEKYVDEFYETIPEKIARGELKYKEHVLHGLDKAGQGLLDVQTGKNFGKCVIVVAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL52</accession>
    <name>A0A4Q9PL52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab-GTPase-TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1041475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL52"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL52"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="381"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="671" mass="74915" checksum="08D551C42C1B0438" modified="2019-07-31" version="1">MVHNTGDGEHDARTAARIHRVPAGFSFNDDAFSDTEDVDVPEFSPAQIREELAKNMNGIKNGNGGALDGWQAHGLDMDDIVAKIGYSVDPDASVSTFDIDAGHESVPSSPSSQARRRSPRMISQASSHQDSLYEVTLSSDLSNVSLSDNPSSPPPPPALHDGEPPEVVAGYPAVQIDLSGSQAQATEIRSDARQSDDSRLSEDHEPSPRPHAASMDEVRKGPPTPLDIPPPNAASASTSALPLSLPTSTSLPTPTTAKLTEPPTPTARHRPSRSVGPSMLDKVISKTRPPYLPPKPRTEDRKHLQDWEDMMKRSRAAVCAPSLLVSDLGPLQEKRRQALLERRLARERRIEESIGVWEREIVPDWTVVHRNAHLRRVWWQGIPTKLRASMWQAAIGNPLALSKDSFKTCLSRAKRALASGSFPTTALRLLEDDIRTTLPAIHLFTPEKGPLYQDLKDMLCAWVVARSDEGLGYVVGVAKIAAMILMNMSPVQGFIVMRNLLERHCLRSFYGGMASKDDVEAYYRIFDTLLADGMPKIYFNFKQHQVSPAAYLPDWLIPLFLEHLPFEACARVWDVIFLEGDAFLYRAALAILGVLEPRLFFPDKKELLELLRGENKAALEVAKRDGRTVDNGKYEIYNLDEENLWERIESMDEWWRESTWKRLIERELPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLZ5</accession>
    <name>A0A4Q9PLZ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_884657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145172">
        <property type="protein sequence ID" value="TBU55240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLZ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLZ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="239"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="696"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="884" mass="96483" checksum="272153B4F9F738A5" modified="2019-07-31" version="1">MRLIETRTGRFRWFDDPRTVRYAVLSHVWSKEDDPNHVPEQTYQDVCRIHREAGDGVPVLPLLSDKIRSFCDLALAEGYEFAWADTCCIDKSSSAELSEALNSMYNWYGHAVVCYAYLPDVSNPSRPPSQEWELEFRTSRWFTRGWTLQELLAPGIVIFLSSTWECLGSKRTLSSLVTSITGIPHTVLTMERALNQVSVAERLRWASSRITSRKEDEAYCLMGIFGVHISITYGEGSSAFMRLQEKILKHIPDQTLLVWGSVLPSTSNTMSFRRPSDVAEHIQSSFNGTSSPLSVRHSIQKQCLLSSSPAAFKNLPPVLPLSAAAFAAALNFPVGDSSHRVFTITPYGIHARFPLVQVQFKDTRIDFPAYLAPLACSDEDGTLYALLLHRHMGTSTPEYFVGTSFEPLGDSTSTRSYSTFYPRAVRLNLSPDEFSSLRASLEVTTVYILHRHTPMQTDLDSDNSGHDALKVARRGSPVILTEGSQKLLALQGYRVPAGRTVVAALSKRQFQLDQASGIPGIVIWNDDEYITIQLGCCNCEFGERVGLLAVLVHARNASIGTTPDQFTDDVHPIDHPVHVRSWTLSCGTATKHVHLAFPSGGELSLTLTLAYRGAAAEASEDVYMLAIEILGFGGPSRPAILKRSSRSPSPAQVAGSAPARLPLQGYSSSQSASPSLTSLSNANIPKIAISPPSNIDLDDNSDDDAQDGQHHESRPSWPGSPDLAKHGSHVVFKASSQFASEYEQGKAPPSATITARPLMPSSVITGVGRELVKTSANPVQLRTDIDRVLPDVPYTNDPGPSHRATSTASGKMPESVGGQPQRTTVSSTTRGSQRTTLVNGSITEPLPIANARTVPLGTRTVEGRLQSTLLAAQHELEIAKRVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM66</accession>
    <name>A0A4Q9PM66_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_692786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM66"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020261711" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17366" checksum="6217CC5ED1E88045" modified="2019-07-31" version="1">MRSARTVLILLHTRLLTCRTQTPSVHCRPLAAVAPRHSACPLSRHGCHVFRSTPPCTKSASLLHAASQRPSPPISCRTFQPLRSLPVRKLRSCAAAVGHRRPIQTRLPSRGCRPRTWPALARSISRVAPCAPDPGPHAHVGNARRASPAGAPHRAPRSGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNK6</accession>
    <name>A0A4Q9PNK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_652760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24735" checksum="6812145C085A5AB5" modified="2019-07-31" version="1">MCSWLIRDLDLLLRSTGLRDLHRWRWMGRLLSSLRTYDRPSVGPECSDSLLSILALTFIPSACYVTSMPACTHRMIVQEYNALRCSLSPLNLVLHLARATGVVQTKFERSVTGASRRGTHIHMAEARRTARPRAEAHADRRLEARRDAARRVPAQAPCHRPKASPRRDALDANASSVSHPAFYWHTHASVKGSSTTLGRTLSVLSEPSRCGVPHALAGTQAAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP27</accession>
    <name>A0A4Q9PP27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_824652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP27"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="278" mass="29964" checksum="7740598A672F5402" modified="2019-07-31" version="1">MPFEHSRLDTSERLITLVDNSGGRHHYTPAQFREYVSHDRALRAGRVAATHVILPGGYDLFAQLWGADATCPYQFSSRNASTNTITVRGAPVPTALLNELNPPLTPAPPSAPPEPQFSEQRMRTIEHMLWGTAEREARFYERRSNQQEKRTDDRRRKRAEHRVSDRTRSAPSKEVLAPPIINTSSGGIAVASGSGASGSDPAALAAPVAGGTSSLGVGGALRTVPNRTASAAGHRESSPMEEDKDAEGEPDELIEYSDPEEAGGASQRRSSCAGKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP62</accession>
    <name>A0A4Q9PP62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_647813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP62"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="7889" checksum="49B5A387C72B9222" modified="2019-07-31" version="1">MVYVTVHTSSLCSILCIVCGAGNTGGRYTRTDITIREQGTIPLTGAAFTRHVSRSASSTRGHIRGIPAGSARGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPW3</accession>
    <name>A0A4Q9PPW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_931566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Basic krueppel-like factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="304"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="111"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="375" mass="41043" checksum="2B94476C26FA2A6F" modified="2019-07-31" version="1">MEVDASFRLPTMPPPTGTPFRALHPYQFAPAEYNPLMPSPDHPPNATHPPSARSEHSGPSDPLDRNHSSHSYYTHPPPPPAHASSSRTHLQSSSTPQFRTHAVNWGLPPIVSSQQQQQQQQQQQQPQQLPPPSQLAGPSMAPAQFPPPATSGRRSSEDVQRAPQAAMLYAQSQQHLPPIVANQGSIAPVTRGRSSSLIATATTFPQGGNVPRLPPIMQVEKQQVTTSATQAASASRRRNEANFTCPVPGCGSTFTRRFNLRGHLRSHTAERPFLCEWPGCNKGFARQHDCKRHQALHTSRSQSNVCQGCGKTFSRLDALNRHLRSDGGADCRHATEAANAANRMSPLDEDWENASNSTERSERGPRRSPQRSPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQZ2</accession>
    <name>A0A4Q9PQZ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_823036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQZ2"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="entry name" value="DUF6533"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10395" checksum="7AAE6C96174FAA0C" modified="2019-07-31" version="1">MASLPPPTLADLNTLSASRYFLPAVATMAIYECLITLANEVDYVWKTGWTGASIVYYFNKYLFLVTYIGGIVGIAVPGASIEVRRNESLYHGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRE2</accession>
    <name>A0A4Q9PRE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PRE2"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
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        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Release factor glutamine methyltransferase N-terminal" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="326" mass="34895" checksum="571EFA1D4996A28D" modified="2019-07-31" version="1">MMTSATLSRALSQLQRAIGRQSARTEFRWMQHTLDNPPPAIPPSANTLEEMVNRRLSGEPLQYILGSQPFGPLNLAVRPPVLIPRPETEDWTIRLASLLTPSPARPLKVLDLCTGSGCIPLLLCHLWPPGSAHATGVDVSPAAVRLATDNAALCGIPPPSLGPDAARGPPPAPALPQKNTFTALLADLTRPTFAHDPRLAPPYDLLTANPPYIPRAQYERLPASVRDFEDVRALLGETPECADGSTVADGRVPAADRAKGLGFYYRIAELVGAHGLLRRGGGTLALEVGDGQAGDVVRIVGGRARVSEIDVWRDPWGKARVVFARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS25</accession>
    <name>A0A4Q9PS25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_881249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS25"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10536" checksum="4A87E1563C856CA8" modified="2019-07-31" version="1">MEEETGRTNMKAETMLNSSQPGGPRTSFKSEGMSGEEVAQSTEKAAKASKALAGMHPFPTEDASFYYWDASVCRWDAFVCRWDAPVYRGSDASVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS71</accession>
    <name>A0A4Q9PS71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_853433</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS71"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024119">
        <property type="entry name" value="TF_DEAF-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237">
        <property type="entry name" value="DEFORMED EPIDERMAL AUTOREGULATORY FACTOR 1 HOMOLOG SUPPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10237:SF15">
        <property type="entry name" value="LD37257P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="1145"/>
            <end position="1186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU57273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1188" mass="132977" checksum="41B66334FB7ADF69" modified="2019-07-31" version="1">MALSLFWPGKYFFYPIGNTSAVCLTRDIPPETSANILLLACGDPRNVLYTIFCETPDLSRALDFTCCDFDPGVLARNVLLLSMIIDGVPKETTWDIFFHMYLDDDSQAALVSQCQKLAMYSSVADWRSSPYGTVIRMGTDHTLAAMCRHWELYANFYHPSRSEQRRDLQKKMEGTRREVLSDTPVVNMSSSRSSGPLLLRYDTVHVASQQFRRYWETGTTFTDATQLANSTHPNSTFFYSRAHEGFDVHYGTDPMIPFHHAPLFGNAKGTVTVQNLVESSRSQFYAWSAAFRTAVTTWKEGLLAIRFLLGDALAVASALQNHSNSSVQTVHPMPRVAAWTACVLKLNPEEYARVAAPVRFEVIDTSNLSDHVGMLNILLCTAPLLAHSPCSVLYTESLLTHTTDSATELESKLFADLSVVSVLLGMAPLDSLSGFTSLCNTHEQLTSLTLSPSDHRQYHQIITWRQPSTGDPSFIHDFTLPPLRFDANQLARLFCDIYVHLFGTEDPAHFMNLKPEDIVRLGRKFACFCPSRESFIVLLSLIHNRLQISAALWSGVMRIFLNLLSDDALRTHPFDRLNHREIHAQLYRHGIYSVPELDKARRPRVGRLSHWANIPPLVRVFLTVPRNEFAKLESIPNTPWLHCVIRYSQSEHGFQSVDAAYGTLIDRGSKAKPDLLFREDPEGHRTHCPVVVSFVVPSCVLTEAAPETIDIRLSVRTNPGSNKALLFLLGPYMAVFHACLEDTDHVHLLPEVPLSPPDTLSSAFVPLHFPKKLSAIGRPSHLAVDMDGTGKRIASLTARLDVEDVQAKEQFAKGAMPTVTQSSPCAMQVVIGGLAQTLLYPIPIVGSERKVRLARKSSYIEVAVPVAIPYLRPDGQRLCPFPVVRTNGSLSPWNLHRVPINRLPVLDLANVDRLRLWYDAHVGSQFSIRERKIRDTEQLDLLTNIKDSIHHVMTKAAGTQGTEKPARVIALRDDETQDCDTMLFVNRIRFDLSSHTIVCDAFVLPTSHAIMPTISPFIGQLLQRGVTSIRVYRGEMRGWKQLLPALVERCRTTWTHGANCEYVAKGKIPLQLKTSAGDPLCSCGRGKDVDGMLHDNLWKKFGPFVTRIAISPLFAVSYVDPVFTGGTEDVASPLASDVKETLAECHRCRKQRSISGELRRCSGCKIVYYCSEACQKSDWKSHKLDCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSL6</accession>
    <name>A0A4Q9PSL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_978193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSL6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="56"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="522" mass="57365" checksum="89736A3DAE36C36E" modified="2019-07-31" version="1">MPPVVPSSIATSLDIVLEAIKRGRWSMSIEMLTALQVQLHLASSLVQETMNSLIPLNRLPSEILSLVFSLAMMPLKPAGYHGPSAARQSYDLLPVTHVCRRWRDVALSTPSLWSTLYEDDVSHASAQLLQARAKETALTIYVNRSNPTRALVQLLGVPRVGSRVTELFLQDLHDCTPSQLATGVLGFPAPHLERVVVRRQVPRNDTASDADDAGAGAPTEPIVRLFDGVTPRLNTLVLHDVPFLPSNSFQRLVHLKLSFETSPIYWTLNDLLHLLSRCTLLATATFVGLPTHFESTQTPSAPSVSLTCLRRLVIVDCHGQASSMRAILAHLTLPADCAIRLHGLPAHRLGPLADLRFPYVIQPMTLVIDVSFVSITLTLANPRSGGSLSLELGTAGAMTTILQQCIEAFVSDFSTSISTVTISSQRVWPAWCDPSLLLSLLPSTNSLSLGDIHLVDQCLDALRPSRSPYEGFDISREPCPRLKVLHLPPGLTDLLRQKLHMVMSERKHKGSRMQFVMNEHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSP8</accession>
    <name>A0A4Q9PSP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_929425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSP8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18009" checksum="532A27B4E2CF37D8" modified="2019-07-31" version="1">MLTSSSVSIAACQPPLTGPGRGCRDAPESICYAHLNVGNASSVSDLVYGSALPDMKACRPFGRISKKADATAEMADLIYYTLTELEKVCHRGSAQSSNRLSISAGGSPYGIEVRVASRTLPWTVPPFIDRACCSRLQRSLVVWRSVTYKTSRTRGFERTVHLAFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTP0</accession>
    <name>A0A4Q9PTP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_928536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTP0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004563">
        <property type="term" value="F:beta-N-acetylhexosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF26">
        <property type="entry name" value="BETA-N-ACETYLHEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020742804" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="23"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="178"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU57872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="567" mass="62327" checksum="4A403444E541F057" modified="2019-07-31" version="1">MILRNWLAMVLLLSPAPRYTTALWPIPSSLSRGATAVKLSSVFDIHIDISSPPADLVAAVSRTRSRITTDRFQRLVIGRSTTDISSISSARTLTSLSLALHPGSLVRSIADETNQPITSRSEVYSLAITGDRPSAILIANSTLGLFRGLATFEQLWYDLNGTKYLLDGGIDIVDQPAFPYRGFSFDTSRNFYPVADILRTIDAMSWVKLSILYWHVIDSQSFPLHVEAYPELAEKGAYSAEEIYSQNDIRTIVQYANERGVDVVMELDSPGHTTAIGAAHPELIACAAKSPWASYASEPPAGQLRIASPATVEFAKTLFDSVASVLPSKMMSSGGDEVNLPCWEEDEETETDLAERNITIADALNDFVQAVQGVITSHGKTPFIKSDMVLTHNVPVVNDTVVVVWQTSEDAVSVAERNLRFIHQPSNYFYLDCGAGEWLGNDVLGNSWCDPFKTWQRAYSFDPLANLTEDQHHLVLGGQMPIWSEQSSPENLDPIIWPRLAVAAEVFWTGATLPDGSPRLGPNATSGRNALARLNELRYRLVDRGVSAIALQPKWCVLRPGECDLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVA7</accession>
    <name>A0A4Q9PVA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_927084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVA7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="129" mass="15428" checksum="985264A9B9999325" modified="2019-07-31" version="1">MARYPECAHLLTVAYSIPALERLPPWRLPGAFSDFQYGDVQLMDTTAEEVAQHVEAIRQECEADKHRRHFEEVIAAERILEEHENRQKDREERRRKTGVKVRKDKKLWTKHNPFYAVRLCIRDKNPFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVI1</accession>
    <name>A0A4Q9PVI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVI1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8199" checksum="E31B43625E0F59A1" modified="2019-07-31" version="1">MHSAINWMQYLRRMALAVYASYSLSFGGGFLFSITRSWDSKLMWATASWTWALVTCSLRQAMAANCFYLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW32</accession>
    <name>A0A4Q9PW32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_444417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW32"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW32"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
            <begin position="41"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="459"/>
        </location>
    </feature>
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        <location>
            <begin position="482"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="856"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
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        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
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            <end position="284"/>
        </location>
    </feature>
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            <end position="319"/>
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        </location>
    </feature>
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        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
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        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
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        <location>
            <begin position="590"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="879" mass="94319" checksum="5555418D6EFCE0EB" modified="2019-07-31" version="1">MSLTSGSRPSPFTLQEFSELVCSAFNISDADLTSRLNQPLLSLTPASPHSPSPPDRIQPPNFLSRGRKAGDPRRSRSSSLDDRSPLSSPARPRSRSGTISARRMFQQVRSRASALVLRSREPPASPSRPPSPAPYEPLPRPCPSPTLSASSFVRALSPWSMLDSTADRPSSRAPSPSRSLLTPTRRSVSPTPLPTRQVQSYGPSVSRSPTSALRSFFDDTPVQSKRAYSRHATSASVVHPLYRVTTSNSVQEGLPHESLPSFFEDTGYRVANPRPPSYCRPVPPSTAIHSRLPPLRKTKSSGHGLLGREDHQSSARKIDGPAMRVGFQDFALWNSRKGENMPSPLTHPRDPPPVPAYVYERRGSATSNSTGSTRSSSSLSLRLSSLVELALPSKMRIRGRSKLNLNTASGSEEASADSSPSTLSSGSLPSTPSSPISPFSRAQAQVYSASTDDHTLPIPVTKPEEDALAIGRVLTPEADPFAKGDIVLPTHGSPRQPIHLSRRASSQDSPSSLNRVVTWDDQGKPHAVKRVRNSLPASPVSTAPTFPSSCSVYSSCSPRSDASYTFPARKSPAITPKRDGPPSAWPSLVSTSSSSGRPATSPCSPKSAFKRNSKPLSSTNDIFSALPVGLPPPFPPPSLPPPNRDLPSVPLSSPRAPSLPPKERHGYISRSHRSLPPSPHPSQTEPSGDHSLNLRTSDDAHVSIIPLSLALQECSVKAFPDRRQVVEAPSLGEPWSGTIGNMQTLGRPATPIPGPRRISKRRSTDSTSTITASPCSSALHDTTPGFDSRTFAASRDGSVLTEGSSYSIEASPRHHSNAVLEDEAEFWSPRSSQSAVFYAAPSSLEASERSRFHTSMAMHSAPRVPTWRAEKAASAEGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXU9</accession>
    <name>A0A4Q9PXU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXU9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16624" checksum="1159CDBF511AC3E3" modified="2019-07-31" version="1">MQLKHDIRGNTYRYTHQHCPPSERDSMLECHTYDERAWQAWVLARREFDRGPSFGRFGSNAQRGLGGRLGNLLSPSALECPILASHIVTRTTRLAINLKPLPRRPTLLSSACSMHSSSAFRAALVCLLLAFVGGEPEHTPSVARLGSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYR7</accession>
    <name>A0A4Q9PYR7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_924249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYR7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611">
        <property type="entry name" value="ALPHA-D-GLUCOSE 1-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43611:SF3">
        <property type="entry name" value="FLAVIN MONONUCLEOTIDE HYDROLASE 1, CHLOROPLATIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="486" mass="54204" checksum="5A4C4CE870C7CABB" modified="2019-07-31" version="1">MPVATQMPSTSQTSGRACESIIVDFGGVLFTWSANTMTPVRPKLLRRIFSSSIWFEYEKGHISEQECIQLVAAEFSIFEVDFTRALKSARRSVRLNTSVFDLLRDLKKHTGVRIIGMANMSSTEWDLLRRKMEPEVWALFDHIYTSADVAQRKPSIGFFKHILDSARLVPARTALIDNRVENLVSAASAGIRACFSFTTVDGLSRSLNAVTRNALADAEGWLRRHAQEMWSVTDSGVKLEENYAQLLIFDVTRDASLANIGTPSKLANFWRGRTINTTVTFPHDLNTTSIACTALGVFPQQMKDDIVDEILSIKTSEGLAPTYFDSTRPRIDPVVNINVLTFLYANGRGHELPEALDWVQSVLQTRAYEHGTLYFATGDAFLYFLSRLLSISPSVRQRLGKLFVERVQERCGTEGDALSLGMRVIAAASVGVRATLDYQRLLLAQEEDGSWPVGWMYKYGSTGMRIGNKGLTTAVAVAAIRKFRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ09</accession>
    <name>A0A4Q9PZ09_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_905623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="21"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="355" mass="38871" checksum="AB51013BEA429589" modified="2019-07-31" version="1">MSSSQAAQLAVQYANNMIGNYCFCAGAVVFLYDSIITTIDEIQFFWRGKVTGAAILFWLNKYITTLTLVWDLATGLSISDKSCALSMKGDYAVGSLLNLIPAAFVAIRVYALGRSWFLCTMAIVLSVVPVGANFVNFWYQLTGKNIFLFGCEEIDHTPVALSTKLVIISRSCLIAADFLAIGATWSTLAQRPHSVHHMSVLKGTISSVFLLDGTVYFVTLSILNCLHLVFTVLSLDSNGLQSTSALTAFTIPYECIFPYRKLSTELGSCFPRLSAILISRFLLHLQSASLRDVGFIASSHATSTNPEGSIIFDRVVGSLGTPIEAHDYIRPEDDYGEDDDEVRNEEADPACTSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZF4</accession>
    <name>A0A4Q9PZF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_359639</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZF4"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="73"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12981" checksum="4E856DAAC446E768" modified="2019-07-31" version="1">MDEHSLDNLDARKTNICPHRRIVTSTYESDMCACWISPQTWRPNRRKPTCLPPPPSIAFSAVLYTATSRSAPPPLCTASGPSISGDSKRQWQSNIRSRVVGSADSPNRWRGRLQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0D3</accession>
    <name>A0A4Q9Q0D3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_847585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0D3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0D3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="121"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20971" checksum="E265B4E92230BDF0" modified="2019-07-31" version="1">MTDLTFCYLHMSRHDIEVLDTIGTPDYLNGDLSIEDVDVAPHLKPPNPEESEVLPSQVHPSYPYGNPLSIKHPAALPRRPYDPASRALFEDMGYGGGGVNGSIRWKDLALDLLFPVDQAREEAEKAAQARQMANGTTSNHPPVPPQPAQNQAVEEDEDENDENDVDDEEQGDGDDEEGLEGESSYEDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q165</accession>
    <name>A0A4Q9Q165_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q165"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="657" mass="73053" checksum="60560BC408EE71B0" modified="2019-07-31" version="1">MSAFDLKRALPLEGPPNFSDGLVGAIDSRHGFLVTSPNADFVPEIVQGIVDVVLRSDGKYGPVDPIQWPQIFTPRFGYLSAVLKPIAPPHHLAPMFTPPSQTDFVPLTGTPVAGFGHITPSFIAPLRTLVEEMSQRIVDFVRKCGGEECADLHWHGVTMRNALSRLRLMPASFPDQLLQVTELQRHWLMASAYLEYQWRLRSVSSADETICAHLPLMGAWSSEPQHVQLLYGAGIPVWYVRTSHILHREICIARSTTPVAPSTLQLARFPGTDGCLFHGLVGEAHLHSMMQGGHEYLDISRVPTASIYSGEDYGPGITIREAKAVGRAGGSASGSRTARSSQSHGEHTLSQRSLRSKPYNRRRVPGPHPSQVRGRDKFVEFPHKWMPPAIPSWSEATLSVDHSMPARPADQLWGYWIPEPALILGPKDEARQIRYLTNWVRARPIWLYLLRVPGSRPTGVGAQYWRSFLNGVPEDSSLTTRTGKRMVEIKNLFGSVFQDHQFNLGTRAPVDWHGHHFEHVPEALAPALGFHYELLALDRFLRPSISRSRAEEAVREDLLATVFPGGWLRAVDALPSDNSSGLFATHPHRRVTALNALRLVLMQWPGCPSAIVSASPLQGNDRDEVIVDLERDLASFYVDTFFTCAGRAPIVPHLYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q201</accession>
    <name>A0A4Q9Q201_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_813357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q201"/>
    <dbReference type="OMA" id="AMAVECN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="394" mass="43735" checksum="1BFA416ECE4C2273" modified="2019-07-31" version="1">MAAAKTIGDVLDSNPVDAPGTIHIYAPDFLYGFQDIVDELDLWKHRGIRGQPADLAHLLNSETGEAGVELIVFGTCETDLGFWHNDLVDAWDRRDADHKFKIVCIVHNILDTNWQRHITHWARRDAIRLLPIANHVKDSFRESFDSTADSSDLELHTAGYQYIPIDVHVPILDIPDLPIKPVHRDLVTAVIQGTLVGERRDYHRFFNDLIASLYEDAAAWGYRPLNSGASVEPDNESNIAPFRLLLVGSGGIEIPAELALIVSVHHDLSYKDFYNLVAMADMVVPAFAQFGYFRDQASSTVALATELNVPLLATDRLRRTYGYIDDARAVVTRPAAMSEVQALKALRTGNASSFLESDPAHTGVAMGEVKGVRDAVERMLEEGWIEANSEEIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2U1</accession>
    <name>A0A4Q9Q2U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeat-containing protein 61</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_874313</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2U1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2U1"/>
    <dbReference type="OMA" id="LDSSMCL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="12"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="191"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="33970" checksum="554FF281E6812A74" modified="2019-07-31" version="1">MSLAFLHAHDGAEPHSDAVWAVNWTNADTVLSISADGVIKQWDSISGQVSRSRPPHTLGLVSLSVDPTGKLALYNTLEGLTCLWDLEDGELKGSFESYARGPGAETTEPSWSVSLNPRGGTYASTGGSGNVTIHSAEPGSFGERRATLTSGRSKFGMHCKYSPDGSRVAMSSEAGQIFVFDVASSSIQAAYSSHAMAVRSFAWSADSTLLLSASEDKRLILHDVRVSSSGKPGSGAVATLSGHSSWVLSTDISPDNKLAVSGSADKTTKVWDIGARAAVSTVQEQGEVWSVSWRPKPPAHGTAGAYVTGGEDGVVRWWRSAGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4W7</accession>
    <name>A0A4Q9Q4W7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_974563</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4W7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="24"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="37723" checksum="EE5DE54C546BF6B8" modified="2019-07-31" version="1">MADQGDLDYAGVVQVFDNFLTGNYLSAAAMAFLAFDWIIGLPREIQLFWGNASVFEMSTERSVWGEPYPVYSLIADRIFRCTRLVWTSFVVEFLAIIPLLALAVLRVYALTQRRLLAAFIFWLLFIPLGASIVPYTYNAQGVVDSIFGCFEADFTPVALFQKWMWVSRMTLFVILTSMPLTYSSAPRRRKLIETLKDNGRTMASIILYNGLIYFVALVVVDTLHLVLSVLSVEDLGGASVIIELRNPIASVLVSHFLLDLQEAHKRSVLLDSHQLVSSGSSAADSGTISFARTTSLFSATIDHDLPGIYDSQGILGPEDEAILVIGGPEADDVYWHSDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5B5</accession>
    <name>A0A4Q9Q5B5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_871450</name>
        <name evidence="3" type="ORF">BD311DRAFT_755795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5B5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5B5"/>
    <dbReference type="OMA" id="EYSVHVN"/>
    <dbReference type="OrthoDB" id="2555519at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38701:SF1">
        <property type="entry name" value="UP-REGULATED DURING SEPTATION PROTEIN 1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="455"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="540"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="214"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="540"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU29833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="610" mass="64705" checksum="2604120FAFC6AC55" modified="2019-07-31" version="1">MEGQMKPKVTARVDFDRPRPASPFKSPSTSLSPPLIRPKAKVNSSATIQPRKAASVVSAAPTRNSPVPRAPSPFKPPNSRTPTVSPAASAVVKSRLTARPNGSNSTSPLPESRQRAFTAATPSTSHSYVRPRRGSASSSHLLVSAQREASVGSSPARSDLSLSWQADENTPTAPPSNVSVRVKAKLSKVADPGVHSPPSLPSSPLLGNRPARVPSISNLNLSPPLMSSGSGGGSPSSASPSPLAGQMRFGSARETKHQSFQALPKAFQAFVANDDTVIDYGASTRSGAKVDPAAIPLPPQSPPISTVSFSSRSSASRSSVSYGTQDSKGSRSTAPTLHSNVNGNGHARQGSKSSQPRGSIDGLAIRSEPMSREPSASEMEFSDDDAPHHDADSEDEERKLKAAAKSNRKIADLEITNRSLMAINSTLEATKNKQAREIRELRRKLRESRLILPPPAYRAVKSSLSPEDLAEEEDDDDDEEDEEDENGLLEGKADEAYRRVRSILDTLLESGRRALESKPEDFVGTGKGTAKVLTAEEVRSWRGDDDLTETRSTLGADADSSFAGSRPLTPSRVAVPESDVGLESEDEVEASLIEPDTPPPLPPITITPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5L2</accession>
    <name>A0A4Q9Q5L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914827</name>
        <name evidence="1" type="ORF">BD310DRAFT_917952</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5L2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5792" checksum="E773914BBBD72A05" modified="2019-07-31" version="1">MTRDAESSRKVLSPIAIRLTVATPGGQRSVSCRIWFRFGRIVYNYSRSTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5S9</accession>
    <name>A0A4Q9Q5S9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH-ubiquinone oxidoreductase 14 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_810373</name>
        <name evidence="2" type="ORF">BD311DRAFT_652160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU62732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5S9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5S9"/>
    <dbReference type="OMA" id="AHQWDER"/>
    <dbReference type="OrthoDB" id="2141050at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39218:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 14 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12110)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="80" mass="8567" checksum="DA005A2A64AA198A" modified="2019-07-31" version="1">MSLLANIVGFSLVGIAARMGQLGIQKRPILENPIGHAIAAGTFGFAGYWAYQWDRRAAVLLAEKRAEIAARRAKTDAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6B4</accession>
    <name>A0A4Q9Q6B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_917492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6B4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6B4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF9">
        <property type="entry name" value="POLYKETIDE TRANSFERASE AF380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="40"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="309" mass="33853" checksum="AEF4A29E623583A6" modified="2019-07-31" version="1">MASFEKTLNIKIPSKTDGWNLDAWKYLPKTAGAEPKGLPVIVMAHGISANKSMGLGKYAEEFVGMGYGIVVFDYRRWGTSDGTPRHVVYVSEQLDDYRTVVKYVRQQPEFDPQRVILWGTSFSGGHVVNLASEENLNVSAVVSQCPYLGNTPFPHISTAFIKTMFAAISDLLKQAIGLSPRYMPAVARPGEVGLMTWADNYEGMFGIVKGDAIYPNEVNASAMLDFPLYTPSASASRVAFPTIIIAAEHDSLCPITEAKKVKDASNKVELVTLPCGHFDLYPGTTSAHDKTLEAMKKFLLDHVPPVRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6K3</accession>
    <name>A0A4Q9Q6K3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_787301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6K3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6K3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7698" checksum="91BE99E5491C9487" modified="2019-07-31" version="1" fragment="single">QLPMRNRTGSTRPRNADENAMSRHVRQASGIALAGASKVPVGHTVKNGVQRPVLTEVTTTAVNRTGKVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6N3</accession>
    <name>A0A4Q9Q6N3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_955966</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VAM6/VPS39 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6N3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6N3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019452">
        <property type="entry name" value="VPS39/TGF_beta_rcpt-assoc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF49">
        <property type="entry name" value="VAM6_VPS39-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10366">
        <property type="entry name" value="Vps39_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="16"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="4">
        <location>
            <begin position="750"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="487"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113987" checksum="7F1DE9533AC41507" modified="2019-07-31" version="1">MGGPFNAPEVVLDGFKERAESLTVHADRLYIGTSTGNLHVYSFGETSDSLVELVDTRKSLCRRSIDQLAYIKDVNSLLVLSEAQLTLFPSPVFSPPTPLVKTKGALCFALRTGVEYLDGDVIIPSSPGIPGKGKGVPALVTKLAVGCKRKIVLYSWRDGEPREPQEITALAHSPRAIAFVNGETLCWGHTPTDYCITSLKTSVTVDVTTPIPPVTSGSGISTMGMGALSGLGGYMTLGLGAKAKPNVTGVNDVEALIAKDNNGFLVGADGKPLRNESIDWPAPPDEIALVKPYVFAILPPGTVPASQLDSVPGASTFIATPVIEIRSSISLSPVQTIPFPPGPLTAFATVATHTIRLLTPSPSAKAPLFVVSTPLDRTAATNSGSAIWCFRMKPWNQQVDELVDAGAYADALSLLESLDSALVADKEQRHKQIRALQAVDYFRSAKYDQAIDAFLKLDVNPAKVVALYPDSIAGRLSVPQDEWIPLYGGPKPKKREQFASPPEPAAKAEDPQKPDQEGASSSVGSPPRAPTPQGSIRGVLKTGLEGLVSAAKDDDAASIRSVRRPPRPDNFHRSIETLMRYLSDRRPKIAGALSAFHITPTQSHEMPHLSTTSVEDLLNLPNAPLSALTPEELVRFAQVVDTALFKSYLLVRPGLLGPLCRVGWCEVSEVEELLREREKYQEMISLYNGRKMHGKALDLLRQLSEKESDPRDKLMPTVNYLQRLGPEHIDLIFEHSRWAFEQDRDIAFEIFTSEEVELPKGPTADFLESLDPAICARYIEFLISERGETSQEFHDRLAELYLRMTMAAKRRGDDGARRSVYERLLKFIDTTDHYSADRLFAMLPSEDLFEAKALLLGRLGRHDSALEVYVYRLQDFPKAEEYCKRVYQPGAGSPTAAVFLTLLRIYLLPGPAAPPAASLLPPALELISRHSPRLDPVATLQLLPPLVTAQDVGAFLLEALREPLFDTRVVRNVAKARQEQVARRLIALQSKRVRITESRICPQCHKRLGGSVIAVHAPHGEVTHYQCREAFARKQKEARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6P7</accession>
    <name>A0A4Q9Q6P7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6P7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6P7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="36428" checksum="B8FCE4B2FAD4A34F" modified="2019-07-31" version="1">MSFEGTRLSKRARPDDDSGGTRSLEDVVQDKEFWLEDGNIVLIAGKTAFKIYRGLIAAQSLVFSDMLATARPDAEQLYDGCPVDRLSDSPLDLRYLLRALIPKTSISIYLSHDENCYTFEQLFALTHLGHKYQMDVVERQAVSCLKLLFTDDFEHYAHGIGAVQLARLTNNPGMLPVALYLCSLDASVLAHGWTRADGTVERLEPEDLERCIDGYEILREETSTVLARIFQFASSWECTAPNSCEVLCLAVFHALASAFSERHTLLHSWEDMYDEWMVSSHVTLCTACMEALCEREKEQRSAIWRRLPKIYGLPVPDGWETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7R5</accession>
    <name>A0A4Q9Q7R5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_585150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q7R5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="493"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1266"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1411"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1230"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="120"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="578"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="706"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="804"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="886"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1045"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1326"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1418"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1456" mass="154002" checksum="D2634050A6170E54" modified="2019-07-31" version="1">MFSVFQSKRGTVAKAQKKFSTIASGIRQRPQSPPSPASFVSPEIVEILEKDPFSASYPEHRGPSTSIDRSLASPQIQLEFDPTESFTDWLSPTIAPPPENRTPPRRNVSLPSGVRPLPEPSSSSRGRSSPEAAIKEEPGPREPNRLFVDTSMHYSQGPEDTNEPSALPSTRKPTPSPIKIPNNLTSAKIRVQRSSTEEAVDINSDDVPPPLPSKSSRPHTPPSAITDDMSSAISGTSLARALVVNSFILSSEPRASKYKSGGGQQDSATLPRGEHPLNDSPYLHERRGSGGSLGTPRSSSVPSVPRLPSGMDNRRNSVSLILENGDKELFDPLPQLRRPKSTGRLRRERTLSMPPISPISEASSAPSLPTSPVIVGQLTSNASNRSLPQRSLDGNASSSSLSTGDGTAGHARTATEPASTGRTGTGNSASRSKGAALAPNGAMPGTMRSSGAFAMNNGRLAISRTVSETGVSRAGQPTRPSVLLPIGERPASVLVPASPQPSLLSNATAAGANPTPTSARFAAAPNNSSSNSVSNANSSSDTPVDSPDLLDNFPLQIAPQRPAGPPPPLPLGRRSEESNGSSAAPTPMHSSSGESMLSTALTDRQTFPETPNAFSPLWSASFQSPPAASPNQNQNQSSRASLDRTPARGVGASRAPGVLDILRMGRGAAPASRMSGSVFAKPGSARSSRGVPPTPPLTGESGGASQPGSPMGSAQSQSQSQKEQQQQPSSPALKRLTAIEEQVASRSVSTYSTVPEPPTSGAQFEEMFSMQQAKAQQSAPPLPLQTRARSGSNAAGRPRKGSVSQTQAQAQNQAQATNPTTTAPSTITTSSAAEQAKAAEASSHRRMRSVANPDEPLASPPPSYVPTFDAAPPTPLLYSRANTADSSVPSRRSSLQSSGHLQAASSSQSSIPQKRSLSPFPSPPNSSAPSSPSPGRSRIDAHASSISVENPPPPYVEETRGATPPIPVPQLPATLCVPPPPLIGPAPPARTSTPDLHPPPGTPRSAYGTPEGTPNKRYTRTRPPLPQGPRKPSYPSSAAARMRAGSVSSLHHGGPSGSSSNPRIASMMSHAAPRFQPSRVQFRGLTMEAAQWTLTSQQLQHIVSTAIRQSADASAIRILPEDTLERGLPEEIERLEALAAELKLKYKLSVRKRNTLLANVSRIAESTESAESAAAVGRTMDELGDVTEGLDQTAEDLYTVTDQLAQLEHLRDVHQRSALAMALRKLNTSFLKQVSEVQRLREQVATLEAERDEAWREAQEVAQEFDDFTDRIMSDTIPTPGGANGKDKDKESLTPSRRSSRVMVARKNSQRASKAGLRSMNRRSQRSSTSSNHRYSGAASPGVWSVQGGGEDIPPVPPIPLRRSIYFPSGDLPTRSSMADSPSSDVRAMIQAQKELCEMLGISMDDIKVGHGPSRRQSMSAIPAPRSPASAAPTRRNSEIVTPNYQKSFKMMSQEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7U2</accession>
    <name>A0A4Q9Q7U2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PRMT5-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_917770</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7U2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7U2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000020">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="10">
        <location>
            <begin position="39"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="9">
        <location>
            <begin position="348"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="11">
        <location>
            <begin position="514"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="482"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="4">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="384"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="466"/>
            <end position="467"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="6">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU63086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="780" mass="86781" checksum="74B3C92DB99FC4DB" modified="2019-07-31" version="1">MPVFSAHHTHDDLNVLSQRDDLGDDTPVLRAVTDARTDGYETICVPLTTDKWKARWRELCILNPDEEQDTLAEIEQRAEAWRSKPAFFRDEVTVSRLDEAECIIPLISDWLELDATDDWVRHDAEIALHQELAFASYLNAPCAILPTPNNRIQVGSYARAINACLSSVPYMEFSVKIPIYDAVTVVQVPSRSPSPVPSPVEPSTSRFSSASSNDLAVGSPPESNLTTWEMWDTIRTICGYNPRLTLTLDLTPPLPLSSTVLNQWLAEPVRYLWLPASTFIANAKGYPVLPKGTQSFIRDIFKLQPTVILSGTRAKKHPRGGELAYLQYVRHLEKTSSFMKAATTAGTVEHFAQGYQDYLQAPLQPLMDNLQSITYQTFEQDPVKYRNYEEAIYLALRDWEKPEKITICVAGAGRGPLVARSLKAIARANVEAFVYAVEKNPNAYVTLQERHRNEWGDEKVALLYGDMRTLNVPEKVDILVSELLGSFGDNELSPECLDGAMRFLKPDGISIPSSYTAYIAPLSSSKLYNETRASKDPKSSETPYVVMLHAINILSDNGTGISGTCGPRIQECWEFEHPRKDAALTEQGLPLTNSHNVRSAKLTFHIPHAGVLHGFGGYFEAVLYRNVGISIHPERMALISKDMLSWFPLFFPLKDPLYLPADAELTVSLWRLTDARKIWYEWYAEAFLPVPSSSVSSPIWKDSLSPMSPSPDSSFLSPLVSTPIQVTSPLLDVPHLTLQVPSGGASFGMAEDRQKEGVSLVKISQTALHNAGGKSSWIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8D2</accession>
    <name>A0A4Q9Q8D2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_869326</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8D2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8D2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12718" checksum="B81E44881668EC3D" modified="2019-07-31" version="1">MDNLRQTVEEFDQWSDDTLEELARLGKGVCGAVYKVRDRRMNVVMARKAITTLEALTKELLREDVHFPTDSSEPPSQYSMSTLNLLLLGLMYAPQKYTMLACSGEARKSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8J6</accession>
    <name>A0A4Q9Q8J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Splicing factor CC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_808157</name>
        <name evidence="6" type="ORF">BD311DRAFT_648779</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8J6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8J6"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12284">
        <property type="entry name" value="RRM2_RBM23_RBM39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000172">
        <property type="entry name" value="RNA splicing factor Pad-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029123">
        <property type="entry name" value="RBM39_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15519">
        <property type="entry name" value="RBM39linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="118"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="253"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU35319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="344" mass="38296" checksum="22BAF9F72EC1CFB3" modified="2019-07-31" version="1">MNDEPSPDDSEARSVFVSQLAARLTARDLGYFFEDKLGENTVMDSRIVTDRISRRSKGIGYVEFRSVELVDKAIALSGTVVMGLPIQIQHTEAERNRLHPGDGNLNLPPGVSAPHGGMQLYVGSLHFNLSESDIKQVFEPFGELEFVDLHRDPVTGRSKGYAFVQYKRAEDAKMALEQMDGFELAGRTLRVNTVHEKGSARYTQQDSLDEAGGGNLNAASRQALMQKLARIDPTPAKMEPIARPNIPQTMQSRSVLMKNMFNPEEETERDWDKDLAEDVKGECESKYGRVLAIKVEKESQGEIYVKFETVDAAKNAIEGLNGRWFGGRQITAAFISDAIMQAHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q989</accession>
    <name>A0A4Q9Q989_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_916935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q989"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q989"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="161"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="312" mass="34228" checksum="819A8EFBF629223C" modified="2019-07-31" version="1">MDVSDILAAHQAKQKAVLVEKDIPLEVDAGFLTVTDLNPIDTESYEADLEEYLMSTARDGVQTLIASLFSLPTISTDDGPLAQLPPPTTQLPRAKPLPKPKPPTKWEQFAKAKGIQKKRRDKKVWNEEKQEWVDRWGWKGANKDKEVQWLTEVPANADVDFDPAKAARDERKARVAKNEKQRSANLARAAAAGSSSDDRKKTIDRTLAVTRTSTASLGKFDRKLDGEKPLKGVKRKFEPTETSASKEKSQNLAIISKLDKEPMAKKSKKSSDSSGDVLNVRKAIRSASKGKGSAALAREGASKGGKGKKGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9H1</accession>
    <name>A0A4Q9Q9H1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_807361</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9H1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9H1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="27810" checksum="C56665DE80CCC0A5" modified="2019-07-31" version="1">MLRDGFAGPSEKTVKPLTPEALAAFKAAQEKTGVVYISRIPPGMRPTKVRHLMSAYGEVGRVYLQQEDAKRAYLRRKYTATKKVHYTEGWVEFKDKRVARSVAVMLNAQPIGGKKGSRWRDDVWTMKYLPKFKWNMLTEQIAHEAAVHAAQLRVELSQSRKEQREYLKNVELARVLDKRAKRKAVGNDGSKGADGEETRPQKVSKKEHGDVSPKTAPREKRRKPKQTEPKPDAEAQLDSVLGSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAH9</accession>
    <name>A0A4Q9QAH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_806763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAH9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="357" mass="39914" checksum="43E76BA05E1A8601" modified="2019-07-31" version="1">MASASPVDTLPIDVWHHIFKFAYTDGGFIGATLSRISRSFRAVSAPYRFHSVRLSKIKGIEKFLAAYEAALADAAASSTDPPRVRHLLFTFLPGEVDMIILEGSFHMRDWHSWQMAKIDWNTRFVARVTRLFELVASHLETFAVLQCPEVVLPFVRCPQFPALRELTLLHEDALFVYTPKKAYSWMEPKDADFCGSGTPPTYEELAASPLFPALERLHLARGYWGPTLPLWDAVAPRLTHLRISGADVLAGLPLWDALSGKPQAFSDLVALVVQPKLKGAETGVDETQAEPLEAVVERLRQVETECPSLDAILVPAVIASPDVDGLWDWTEWLIKEWTARAVGERGPWVTKESEKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAL5</accession>
    <name>A0A4Q9QAL5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_865788</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAL5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAL5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="3">
        <location>
            <begin position="270"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="464" mass="50191" checksum="4B6112591859797F" modified="2019-07-31" version="1">MPSNVKGQRTFIIGVGCTAFIKPRGLRTTEEMGLEAATKALLDAGITYDAVQAAYVGYCYGDSTAGQRALYQLGMTGIPITNVNNNCSTGSTALYNANTLVKSGLYDCALALGFERMARGSLGSNFPDREPPTAVFNTASIELEETLSSGKNHGPGAPRMFSNGGQEYFDKFGGNINHLAQIASKNHKHSVNNPYSQFRDGWSVEQVLAAPKITEQLTKFMCSPTSDGGACCIVASEDFVHQHGLENQAIEIVSQALTTDDPSTFETRSAMNVVGYTMSKNCADEVFAQAGFKDGEGRDQVGVVELHDCFAANELLTYDALGLCEHGQAHKMVERGDNTYGGKYVINPSGGLEAKGHPLGATGLGMHFYITMQLRQWAGPMQAPGLFDVSDKRGKFGLIHNIGLGGAVVCSLLRRPEFFKEGGEDGRKRLGYNHGHEYRPITREDVDKVKAQKNSPYILQRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAY1</accession>
    <name>A0A4Q9QAY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MSF1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_972283</name>
        <name evidence="2" type="ORF">BD311DRAFT_648743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9QAY1"/>
    <dbReference type="OMA" id="YCPWNEK"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="180" mass="20691" checksum="81DCDA215A233FA2" modified="2019-07-31" version="1">MHYFSQLFNYDHPWSHVVIGMWHKYPNAHCSHVVTIDVVDRSVDPNTGIVRTERILGCKQKAPTWIVKLFGGSEDAFVREVSFIDPATQTATITSVNLSLSQFATCYETIRYSPASRGQTSFHQTAEIQAQMNLWRTASDKLENWLVQRFEQNAQLGKLGFSDVLRQLWENRDRQQAQTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB46</accession>
    <name>A0A4Q9QB46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_943863</name>
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    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19809" checksum="4AC1F8CBB83F7F0F" modified="2019-07-31" version="1">MTRFPDRELISRMTRTCSTLYRGGAIYLLKDDVALQTEEQLLSFCLFIAVDERTRLHHLRTLTLLCDPLPQDVTEGLVHIFKRKSRSKLVSLEILFGTMSIHPVSVLAAIAPTLEELIVYYDRTVRHPLHPPAVYPKLRKFVLKTDYPILRPYINAFPKIAQITLKTCHGTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB67</accession>
    <name>A0A4Q9QB67_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_902622</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB67"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB67"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="839"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="861"/>
            <end position="878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="884" mass="96818" checksum="C1923897BA87422F" modified="2019-07-31" version="1">MVSQAAAPGAAFKVLSPNEAIQFILADIPNFCVGILALGTFTFFLLMKRVDRWIFCLHVSVLLAFLAAIFDLSQLLIQGRSSNNGLTPAGVSGLTTVREVFYSFANGLRFLFYWGFVATIPLGETVPEGNKMHSGSWRRWGLMGLVLKWSTLLLVLLTTILQLAFRDVSALEQIGPVYEAESTLEIILSAIFILKLLLNTWARFSVGSNTLSRGKMMMQYAPIIVSLLFSLWIAVGNVILFEFTETALGRFMRAVEFYIAIVYMLTISFHHLRHLSFFPVYRPASRPNTVNKRSSIDKPRMMMVKNEPKQVDLVEVLEERYRGAQEIPQTVERNSARSAKVESSNQHQSMAARLSTWLGVGRPQSNVQSWDVDTERGPSPVLDAVITPWYAPEQEAARAPTPEGPAQPALDEDERRGVSPLPDYTPTETKPREPLPSSDNTYAPRPLDADELEPAKTPVPNRNWQDVEYSNAVRYSGVNQDVLANALSQRYYKTQDDSPIASNIQVVSPPSDDEASMRRNSIGANSEYMASPYPSSPMASAVTPLPRSRPLPVPDRPTSMLMSPMTSVPPDSARSSNMSILLRRQDELDKSIAALRLFSPTQPQFNVDQAPDDSAEYEYQYAEGSSAQASIGHSPMSAAIAYAPSASPEVPLTTPRTGPQWSAQSEFQFDQQPPLNRSSMDSGVIPTMSLPVVNQAPSSLALPRAPTSRFSDGSSVGERERRIDSMGTQYDITSFVGNLTVPVNPKDSVMSATSVAYSDEGMVNVATVAQPPTFARPTLITQQLAASVVPRGDPNPSMSPYLSARRALPPIPQPVAQPQPQPAAGSPAPLRFRRAVGLPANPKLQLATRNLTPVDEKTRSPTDTTTLETSPQSGSGTPMTGKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB80</accession>
    <name>A0A4Q9QB80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_530637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9QB80"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="473"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
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        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="48750" checksum="81BC84030731969C" modified="2019-07-31" version="1">MPSTSTDSTPGDGASSSSTTSTSASHTTTSTSSTSTSSTSSSISSSSSASTSTSTSTSTSTSTSTTSLSSTTPTSDTFTSTTSTSSPPPDSSTSVSTTVVDSDTTTTVSSLSTDKNTVTASETASTTLTFPSEVVTTTLQSTVFLTTTNSAGQTVTSAPPLVTETLTRTNSDGSPNVVTIVADNPTPISNNSNATQTSQFFRNKGAVAAVFVIVGLTAASIALFIFFYVRRRRRTQRLEHDAAVASTLAAAGYNRRPLDDDDEKQMSPHRSSVPSATTLPNSSFSSAQQLAMVTGGRTPPADGGGATTPPTPGTGPEFDPYAAVGTMHPPPAAFPSQARKDGYAPARTSSPPPGAWDRTRRQTQSTSTSASWGHAAKGSVASTEPLLAGYYSGANTEPSTPAMGATLNLADEGGRRGRERERERESGASSSSQYSDDEPEVAETKPKLEVRNNTPSMRIAPLSRQSSRRTGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC01</accession>
    <name>A0A4Q9QC01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Laminarinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1034425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC01"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC01"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020528442" evidence="1">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="6"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="301" mass="31808" checksum="7070EECC45CC2866" modified="2019-07-31" version="1">MLSTVLILACVVAPALSNDFLSGFTHEAIADPTHGRVNYVDQATALAQNLTYASGDTLILRADHTTVLSASGAGRNSVRLQSNKVYSNHVTVWNIRHMPQGCGTWPAVWEVGQDWPNQGEIDILEGVNDHGPDQATLHTNSGCTVGGTRTMTGTSTGDNCDVNATGNSGCGVTSTDASSYGPAFNAAGGGFYAMERSNSGVKVWLWLRNSGSIPNDVLNGGTSVDTDKWGTPLADFPSASCDMASHFGPHNIIINLTFCGDWAGAVFANDGCPGDCTTYVDENPSAFINAYFDVAWLKVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC58</accession>
    <name>A0A4Q9QC58_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_943753</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Lipid-anchor</topology>
            <topology evidence="10">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC58"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC58"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 10" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="9 10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033933" description="1,3-beta-glucanosyltransferase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="775"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="832" mass="87404" checksum="FD75FBE19AAF739B" modified="2019-07-31" version="1">MHRLCLLPLVSTVFLRYPCSVSSSSVTNSRGAWRSFAALLMLIFPTLIQVGQINTSTVPRGISMVNINMTGYGQGLAAALGDPIGGLYATNASAPLQQMEGIRDTYKFGLYSYCGYLNGSQGTCSNTSAANRFEPFRVITADMLGNYTGFTTALITQGTFIDSNYLGDFTNGAWYLILIGTVAAALALLTGFLKHTLFFLLSTAFAVLGALSLLIGATIWTVIIKKAEGINNFVVGSAGSPTPLGITVSTGDALFLLWASWACLLVSCLPYMIRLSDVHPAVALTGGVLALVAGAHALQKVSRVGRYLYTDDGNRFFIKGIAYQEQGAASTDPNNPFSEPSTFIDPLQDGTACKRDIPFLQQLGVNTIRVYSVNSSLNHDDCMSAFSAANIYTIVDLALPGNGSIDRLNPTWTTNLQDQYINTINVFNKYDNVLAYNVGNEIIVDPSGTGAAPFIKAAARDIRSYLNSVGSSALVGYAAIDGDDNWVLPLAEYLSCDPTSANNGSSAIDLFGLNNYEWCGNDSPSAYSGTNGNFAGYNVPAYFSEFGCVKNPPRLWTEVGTIFSQPMSDIWSGGVAFSYFPAESNDGEFGIVTINGNTVTTNDDFGRLQAQYGNVTFPTVPSKSSAGTTQFPSCPPNNSSWLASNTLPPTPNDNECQCLASTLSCQFTPKTDNTSVIIGSLIDFTCSTLPSVNANCDDISGNGTTGSYGRVAFCDPATKLSFVMSEFYEATNRAATSCDFSGNATVNPNAPTSASAENAAASSCLSNPNAVFTPSSPASASGSSSTGGSTGSGQSGSSGNKNAAESLFESKALFGVGIAALLSVLGSALTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE11</accession>
    <name>A0A4Q9QE11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_35592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE11"/>
    <dbReference type="STRING" id="114155.A0A4Q9QE11"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="1">
        <location>
            <begin position="403"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="758" mass="85123" checksum="54573D3113E71704" modified="2019-07-31" version="1">MYCTRDIPSAPYQVFMSRRSENPTHTVTIRRVSTINSDAVRSLTRRRSSNDPSAMDMNAKSLGLLQLIVRQAPNMRHGFPADARSFYVDSKAKDLRIGLSAWRGFFQSVRPTLGRLIINIDVSHALVYTGGPLVTTMMQYLNLRDSRGLQTLSPSDFRKLRTFLKGVVVSITVSPKMRARPISDLVLAAGQQVFDKDNESWTVQRHFETKYGKQVRYPKYVGVKVGRTAIIPAEFCIVRSGQVFRKMIPPDVQRGFLEFATQKPDHRFGAIKSAVTGGIFNYADSDYMREAGMAVSNEPMELSGEVITPPPLMYGGSQQLQPTGGSWNMVGRRFYKPGVMRSWMVVNYSSAQEQVVRQFIDKIEMSLQRLGLRFPARPLIYGGQPSDPKKVLEDRGSQVRPELVICVLPHDAAEIRQAIKNWGDCKRSISTQCVRGGKWERANDQYCHNVALKINARLGGVNSVIDDPGFSKFLGEAMIVGADVGHPGPGVTNRPSITGLVASLDPQASVMTCCSFVQQPRQEMIEDLEEMIFRFLGDWRSYRREKLGPQWDRPPKTVVFFRDGVSEGEFDRVAQYEVPKIKSAFAKAQIPPNLWPKIIFIVVAKRHHVRFFAKHSDDRDRSGNCPAGLLIADSIINPNYENFYLQSHAGLLGTSRPTHYIILANEASLGIRNIQQLTFKLCHMYVSATRSVSIPAPVYYADRMCTRLPFFCTNGASLSDTASERTGSTAPNAFDLEQWKRTAGFQTPVGLRHRMPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K3M6</accession>
    <name>A0A4V2K3M6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K3M6"/>
    <dbReference type="STRING" id="114155.A0A4V2K3M6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="1">
        <location>
            <begin position="99"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="40982" checksum="30C91A4D661ED058" modified="2019-07-31" version="1">MAQHSYPALAHIAENLTEEGLILGPSAILARRYVPELQELLAMRSKGWNEETLDDHFKWQRTVADNPDKEVASTWFHMMKKVMQEIDLASGCISPLKPIEFLDVGCSSGGLSSYVLRKNRHARGTGISLPAVQGGHIFLLEESFLPRYEFIEKDILAYDISPFRSDSTTVSSQRLPGRFLRRFSLVLLGESASRTYHHPVEPAPEDRKTVYGAYRDSLLITQLIIGLETVCPGGTIVMRLSHVECWPSAILLYLLDHLSDKLTVHKPRTMHASRGTCFVIAKGACGMQHAKARQQYLSGLRELLVQLRSGGRGGRGRMILPGDLDFVATAETILTEYLDRLVELGRGVWSTQVQGLDRLFRKKGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4M3</accession>
    <name>A0A4V2K4M3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mitochondrial ribosomal protein subunit L20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_974826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4M3"/>
    <dbReference type="STRING" id="114155.A0A4V2K4M3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024388">
        <property type="entry name" value="Ribosomal_mL58"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28266:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12824">
        <property type="entry name" value="MRP-L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="207" mass="23471" checksum="55009D16008A74B0" modified="2019-07-31" version="1">MPKSDSKHGTCHMGLSRAALNISSSPAMPPRLSLPSLRFSSRSYATRLPERPPYRAPDPLRDNPHATYAELQENVTFIHRPPPTAPSPLSYTTSPASPLLKSSGFSTTGELPPTFSKQHEEKPRLSDEDVARIRQLRREDPTTWTRGRLAKEFNCTPWFVGKITSLKGPDRRKAKETAEEEHAANRAKWGERKSLSVDIRKKRKEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4X6</accession>
    <name>A0A4V2K4X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_821764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4X6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10872" checksum="6CC325CBF1417577" modified="2019-07-31" version="1">MLPRGDFAPGGSLPYERACAAASPTSRKLFSMLGRCLVACIFRRDARDDQTQVLILVWHDVPFTRLPSLAMTAFSARLCMHMQFASFQETRMLACLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5P5</accession>
    <name>A0A4V2K5P5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_915374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5P5"/>
    <dbReference type="STRING" id="114155.A0A4V2K5P5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="513"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="943" mass="103414" checksum="6F4A3BD5E0DB2D6C" modified="2019-07-31" version="1">MITFTPLSGPARSARTVPLAYLLQVDDVRILLDCGSPDWCPETTQDGTEESELAPWEKYCDSLKECASSVDLVLLSHGDLSHCGLYPYAHAHWGLTAPAYTTLPVQAMARVAVTEDVEGIRDEQDVGDTTEAKGTQESSSEPSGSPVLGENVSSPPPSSEGKRRKYVATLQEVVDAFESVNVLRYSQPCHLQGKCQGLTIIPFNAGHSLGGTIWKIRSPSAGTILYAVDMNHMRERHLDGTVLIRQASAGGGVFESLARPDLLITDAERANVTTARRKDRDAALLDCVTATLSSRNSLLLPCDASTRVLELLVLLDQHWNYSRLKYPICLLSRTGQEMLTFVRSMMEWFGGTISKEDVGENGENGRRDRRRRDDDHDEEALGAFALRFKHVEFFLSPQALMSTYSSKDPKLILAVPATLSHGPSRAIFAEFAEIPDNVVLLTGRGEPGTLGRLLFDKWNDSQREEAKWDRGKIGNNIMMDGVLRLEMHSKVPLQGEELEEYLAKERAAREKAAAQQAALARTQRMLEADEAESESEDDTDESGSDSDEESEVERTLGEDFMDTAEEGKPVRTGRTNGRRKRKRAEGGGADGDWVVGGNEPEDGAVTRISFDIYLKGNVTKATSFFKSAEGQTQRFRMFPYVEKKRRVDEYGETVDVGMWLRKGKVFEESTESEESKEAKRRKEEEEAKKTPREPPSKYVTSVAEVQLACRLFFVDLEGLNDGRAVKTIVPQVNPRKMILVHAPQAATDALIESCASIKAMTKEIYAPPQGETIQIGQHTNSFSISLSDELLASLKMSRFEDNEVAYVSGRVSSLASSTIPVLEPAAITHFQSASAPHQPLRGRMLGSRPTQALPQSTMIGELKLTALKTRLASIGVQAELVGEGVLICGAAAKKGAGVGLDSLGDSVAVRKTARGRVEVEGSVSDVYHTVRREVYSLLALVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5T1</accession>
    <name>A0A4V2K5T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_431344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5T1"/>
    <dbReference type="STRING" id="114155.A0A4V2K5T1"/>
    <dbReference type="OMA" id="EWHAREN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polyketide synthase-like phosphopantetheine-binding" evidence="1">
        <location>
            <begin position="564"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116127" checksum="88F8B5D744008859" modified="2019-07-31" version="1">MTAVPAFRSPRELVISGELSMPELYEWHARENPDYPLYRFHDGNEVNTLTYAQVIKAIRRAARYVQARIATPQIVAVIANIDTITYSIIQLGIMRAGYTMFLISPRNVPAAVADMLRKTECRHLLLSSDALVQDLAKKALAELNGVTLHDVPTFEQLFPADASVDGLSTEDLPATLDINGLCMILHSSGSTNHPKPVRWTHKKMMSWSSSPWYGEVDLSQVSLSIHGTPMFHAIGVMMYCLAANNGMLLGVFPPASPPTFPTPENVFDGIVKTSSEYIMTAPAMIEMWAREPAKVEHMKTMKGLIFGGAPLDQGVGDMLASQGINLYSLYGSTEIGAIAKFFTANPGMDWAYFQLNPMHDQRLVDAGEGRYELIVISDPEIPLPIVNTKFDGKDAYATNDILERHPTRPNFYRYYGRLDDQIILSNGEKTNPGPLESIISEDPHVQGCIMFGQGKFQNGLLIEPTPEYRFDPQDLGKLVDFRNKIWKSIERANEFAPQHSRLFKEMIIVTSPGKPFSYNIKGYPRRTWILKDYQEEIAALYKVVEESAQSDVGAPAAWNNDSTRTFLRTVVERVLKKSIPDDADFFRHGCDSLQATWIRNTLLRAVRETSPTSAKLLPMSIVYQAPTISALTEAVLHILHNKGVAPTATTAHDLVLIAEKYSSNLPPRPAQLRARQSDKDVVLITGTTGGFGCDVLEHLLRDERVERVYAFNRPGSQAMERQLTRFKERALDESLLTTPKFRMIEAALDVPGFGIEPQLLDEIRDSVTHILHNAWTVNFNLALSSFEPDLKAVRNLVELSLSSPHSSPPRIQFTSSIGVFASCNIPPPIPEVSLDPSSPLGSGYGESKWIAEQVLYNVAQRAGVPIVVVRLGQISGDKTGHWNEREWFPALVKSASLTSHLPNVEGEASFFLSYPAARAFVEMRSSPEPILHLVHPRPIPWRSLITPIAQELQATLVPYVEWLAALEAAAERNAEAAREHPALRLLDFFRSSASANTKTPLGLYQLDTKKAVGASETLASMPELGEADIKRWIAAWRASGFLPASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K617</accession>
    <name>A0A4V2K617_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_845977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K617"/>
    <dbReference type="STRING" id="114155.A0A4V2K617"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="558"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="982" mass="109586" checksum="6066F950D76A68B4" modified="2019-07-31" version="1">MPCNWSTTTSFLSRRACSTWTSFNAVKRQGMSRAILQGGSFWHAPVTRAQLHPVACIDSRNSTLSTSPMHGCGRAYSAAVDLSSPPHANNAPQSSLSSALASTTAQLSAAQVSRAAAQAVRLCIKEGGFGDALYVVNSACHSVLRDPLQPQKDNARNSRLQPISFGRPVSPRLAAHAFLHGLIRGGYTRKANVYAKLMIEAGITIRTRTLESVITTALSRPSTLLKPGPFARMIPKKQVDATSAAFKLQTGMVTEVCARAALELLQTARTFGQQRTERMYRVLVETLLMQGEIIVASLLFVLLLQDWELRKIQEGATQEATKDRITYDHLGVDPPHPAKILHAPYPDLQIMGRILEVARKSLAGISDNEKDLTRITSLQSLALFAMLLDTGQLHTHRVAVVIHALYNCPKTNTRVWILRDGELVQVGAYRYFHDVLNRLVRSLSTDNPPRPLPTMSRRSYNALLMYSLRHRLSPAMGSIVLQHMCVERKPPLRPDIVTFNILLRSGTLMRKLSLSEGVLAALRLGNQELKLESSSFNKVAPDSDAGPSPVNATDKSSDPSSASDLPPSDFTAAVAQLSKEDVVAPEDIINPIVTLEPNNHTLTSFITHLTSTGRPDAIATVLFDILPELNVIDHPATNDSANVHTTLSYTRALKQAVVRGPYLYAALINALVKAGEIGLAERVFILAQQAAIASSLRNFVKEVKPWRLSVHAFTSLLQGYVRLALGHLPKYKRDQYYVGTKLLSRDILGWEPKARHYDAGYAQFVYEMREENLAALRKPSSKRETSRRHAMLLYRSMMLGARSLLTGLISRKATWPTHYDSSRVTQARVGRAWWWKTKPDARFFNVALKLFSAASRAERSKLLPSRIWHKRLRNAKRRYGETGEMADGWTPMLHHVARAMVAHGFDVPVAYRHLLVGKWKGSMKARRKRPMVFHRPYAFPPARVERREWPHSLPTVKTRGLPVRRRWRKRTTVDCESKPVSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6D8</accession>
    <name>A0A4V2K6D8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_953048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145281">
        <property type="protein sequence ID" value="TBU51853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6D8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="45654" checksum="426AE7436D622D26" modified="2019-07-31" version="1">MSTRKTVSSKTMSSRSRSRSATSAMLEVADGDKKRLFLICRPIFYDTARRRHPDRFVFLKDVWRIKYDGLRPEGEILTELNRHHVENVPTLFCHGDIGEPVQETMTPKYWELENCTSSTLQFTAHTHQEAYRLDTIHHDISAGNLLLYPKVEDRDPGRRVLRWVGLLTDWEFSEKIDEPRLGRRAERPAVELIDDLEAFFYVLLYYVFRYLTSNCLSAAAWIEGIFDGYRIVDDVYYIGEGKGSAIRTGKLTLPCSFAAHYKVLDYDKRQGNICIHPIPLLPPPPPMDHVTDEIILPKDNRNPQFRKVSRHDNIPPTREERALAKNVADHRPFLDILQDALFSLAWDLEVDRLEDQISREGMPSRQSGPSVDATGPERTKRRIGPGSRSSSITNETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6P6</accession>
    <name>A0A4V2K6P6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU53033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6P6"/>
    <dbReference type="STRING" id="114155.A0A4V2K6P6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15133" checksum="0B2D3E0E0E284F43" modified="2019-07-31" version="1">MDMVSLTGSEAVRREVEKVVQGLFGKALLELRQRFVHAGLRVHRSAKVVTYMLSAAIVAVPDADLTRAVPTVFFGAVGTASQRCTATLDGGNFVMPTIAIPQEVNVKAKVWSTSMLAPVLKEARLTSSSRRSSGTTACRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6P9</accession>
    <name>A0A4V2K6P9_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_981422</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="330" mass="36249" checksum="EC8A7C91F94A73B4" modified="2019-07-31" version="1">MSRLLPYLFSTLHHIYQLFMANTHPQLFAIYIEPPDGPDTGSGGLESLSYRSAYCFYVNNTGAHELVLSRIDYCKMVQGVRHEFVLTHLASPLGAVGLIIWERQGFHPRNEKTDDLPSPAPAPAPSPSPLFTSNAPARLSEMLDGLKGTELAIDRAVCIDGISTSPFRLAPYDVLASVTPSPPIAFHKALAAFKVVSRSKPYYDTRLANCYVFGLTFFRLLVGPDVWEREVMKGAFTESAGVFHLPPVSINVLDRSVNGASELQGEFEKEVKALEAKAAMSKRQSTALQVLTEQGVYSGSTSGQSAQLNLPDVGMRMVSTDLEISAYYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6U3</accession>
    <name>A0A4V2K6U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_909440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145211">
        <property type="protein sequence ID" value="TBU53553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6U3"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="450"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="568" mass="63470" checksum="694090E6B1D2E779" modified="2019-07-31" version="1">MSLSLYLDFRPKSDSGKSQGLPFGRRHHVNLSSQHCCEHLKRHLSSFASALIVAPFMWLLSTDRAELHEFASPEAVQGGYAILSHVWDDGEQSFQVTQTLRELALPNNAPRPPETYLLAPNADAFKACRGITYNPPSHDYHHVPGKFRRTLHNREHSGTPTFSITPHGVLAHIPLIEDWDEYSDEVTAYLFWSSSIHRNAPLGLRLKRSPTSADPLRPHYDVVAERLVRLTWDAEGRIAIGGAPVHLSWQEIYITHRPPPESAIHEHANKLFVSLNLGYSVPFRINNKDIDNLPDSPWPMALTRCTNMPELPWDGSPPITLQLDLLDRDLELRTCFAMLSLGRCTSKRAHWACLQFTQRSVDRIISDDDDLGHDCGVDHIEAWMDRSKTFEFQPEEVGLSTTVIQGPHGPSVYRSSVTLKFNTCPLNPQNTLIMNILTTKRVVTLPSSALPLPSGPKVPPHSVIERSPSAERTQEDISGKSEQQPAQGVVALPIEDNRPFTPDSPYPYISPRRDLDHPVQDGNGRTTECPNGADSTVTRPPSQMPTGGVVKEHGPMPCSWNLGNKPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K821</accession>
    <name>A0A4V2K821_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_906623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K821"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="42747" checksum="218FF3BF88FBC63F" modified="2019-07-31" version="1">MDSPTKHYADLKPFSAHTSLPTHITTPAQQTTRAEEAQPAKTARRSRMSANRGITVHKLALELPQACSPSNSLSTFINALEDASPGWYQSLMDSALPHSGSYSPLASPQSSSSFSKSLTESVGSGTSLPKDGLPCDMLGAMRELEELATAVRHLPIPTLRTVVVDWVVSPLTPDVSTTPASERKHLTLPPVTSTSSTLIRPGERKSAPAVRSKEVLRETLPSDYRAPSAYAPSPNQPAIDNLVYHPKLSKTLGLRSLPSWGASGTAAPQTPTPQGGFDGGLHSPQSYWEDCRSPSGKDLPTSVERLPENHLPSKTPKSYKIASFFRRRPTAAAVVEDWPEYRRDPALRATHVPESVPRVLRSAPDGPANKGSSRSSPILEPPPSLGHRQLDSFLQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8A6</accession>
    <name>A0A4V2K8A6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_1038651</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V2K8A6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
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        <property type="match status" value="6"/>
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    </dbReference>
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        <property type="entry name" value="SIGMA54_INTERACT_1"/>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="4839"/>
            <end position="5061"/>
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            <end position="812"/>
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            <begin position="4186"/>
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            <begin position="4443"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
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            <dbReference type="PROSITE" id="PS50234"/>
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        <source>
            <dbReference type="EMBL" id="TBU59248.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
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    </evidence>
    <sequence length="5064" mass="561820" checksum="D30A5DF7C54662AB" modified="2019-07-31" version="1">[encoded data, 5064 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9E1</accession>
    <name>A0A4V2K9E1_9APHY</name>
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        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_584091</name>
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    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
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        </location>
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        </location>
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            <end position="1472"/>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1478" mass="161195" checksum="EF7C4073EBB8937F" modified="2019-07-31" version="1">MRRPTSLVVDTDMTSTTSTTPSASATNIPQSAVTLHSVESASSPSVCPPPQASIPLLFSLLTRRDFFVLILPAILTSVFAGGVAPFMTYVIGRSFDSFAAFPTTPNPSDEAKHKLLHGVGMAALELVGLAVGALALSSITSSLWIWTGERNLVAVRKRIYSAVTGKEMVWFDTKMGSEESVQSVEGNGPIGAGGLMANFARETDEVRMASSLAMGMVIQYTTTFLTSLVLAFVWSWSLTLVILSAVPLLMVIQTLSQGFAGPRLAVERAASASAATLVDRAVAAIATVKAFNAEKYEEEQLSEMLERIQSAANKCHAVWGVSTAASQFVMMAMFVQAFWFGSKLVRDGTISPGTVMSVFWACLIATSNLQMAIPQLIILTKGKFAMASLLTLAQSQSTSSPYGIPLSPTKSQSRRPSATFRKIRLPKCSGHFELSDVSFAYPSRPTMPVLQDISIFLPPQETSFVVGGSGSGKSTLAQLLLRMYTPSSGSIFLDDQELSFLDEDFTREHVAAVSQNCILFDMSVHDNVAMGLAGPGSKRKPQDVTREEVIKVCRAALMHEFVRDLPDGYDTQLGTDGANLSGGQKQRLAIARALLRNPTVLILDEATSALDATSRILVFEAIKRWRQNMTTIVITHDLSQISSDDFVHVLKDGKLIEQGFRHELESFESEFTLMARTQDSEGGFKEKTLEEGAAEELPIEAILEKQNEEMREELETIEMTSRTLKHHSIAPSTFRPLTMGNWMFDAVAELTRSSVVPNRQPRPVSRFVPADAFTGVSDEAEKKFRRRTLHIDIPTVAVPAPLATAASSNRLSLQFTPTSPTLCGHPSPKSFAPSMVEDDEDFDREKAAIQRSGSMAGEKRHYRGHRRRHTRDVRLDAVIIEKAEETVKETAAPQETEVSFFRLVREIIPTIPNKPLVVLGMFICLASGTVTPLFSYLLSRLFFEVSNGAHNVSIINVYGGIVLAIAAADGLLIGLKIFVMENLAVKWVTHIREICYSRVLAQDKKWFDKPENASSRLVQILIKDGDDARSLIASVLSQSLVVSAMLGVGLIWALVRGWQLTLVGFAIAPVFAGVMALQAKLVSKCEVRNKRAREEVAKQYYDAISNVRAIRAMGFESAFREKFDAAVDSALTTGVRGAFVEGCSYGVASALIYLAEALLFYVGAVLIANGTFSYLQMIQTLQLVVFSVSIGSQLMAFTHRIAKSTRATRDFNRLLKLSTFTDESEGILAPDLSGPVSFTNVSFSYPERPEVAVLKNLFVEIKENECVAIVGSSGSGKSTMAALLQRLYEPDTGCVAIGPHILRSTDVHHLRDHVSVVSQQPNLFDASIAENIAYGNKSLTLEDIQRAAKAANVHDFVESLPKGYDTLVGENASLISGGQAQRLQIARALARPARILILDECTSALDAANQAAVMETLRHAKVGRTTLVVTHKLAMMRMCDKILVVHDGIIAEQGSYEELMERRGVFAQLANGGEWMSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9S2</accession>
    <name>A0A4V2K9S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_866533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9S2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="19072" checksum="08AE8CF61D7BAC42" modified="2019-07-31" version="1">MASPTASASTDPPYYVLISHSQSLNISSIPTSTSLSHPVIEYHYADDAPISLLPQYPGEPVLVLDYDPGRPGTPTVKSLSPDLVVSALKVADPPGASVAGEPAITNNSNIYVIETIPKPPDNSAAEGDEQHVHAVLAQFKQRNAVLRRILDYPYGNGASPVNGLQSTNGAGQETATSSTPQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVY8</accession>
    <name>A0A4V6MVY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC73-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_937027</name>
        <name evidence="7" type="ORF">BD311DRAFT_756909</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143414">
        <property type="protein sequence ID" value="TBU29303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145201">
        <property type="protein sequence ID" value="TBU53957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVY8"/>
    <dbReference type="STRING" id="114155.A0A4V6MVY8"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11990:FF:000004">
        <property type="entry name" value="Potential RNA Pol II elongation accessory factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="252"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU29303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="431" mass="48274" checksum="8E0A35590F037E26" modified="2019-07-31" version="1">MSSPSDPILALKEAIKSSRGKPNITYKKGSTTVISFADATHLVLSPKATFPKTAPTRLRKMGATSTDPEAKPEDFYSLGAVYLAWMLRDAPGADYMKRIRENGLAVGFVSVTDRKAIVDWLTDKSQTLHGLITVEVASTTPPGTPPQLRASAALPSSSSFSKLSESTSSPLKRRYVIDPADIEVVKRIKANEIELQDRNTVLRGIKPNNFNSLKESFADKLKKLREGGKSTTSMSTLTPTADSKMQPRKARNQYPIIIISSSPTSLITMHNVRRFLQDAVFEPSQEARTRAAAEGNARPEDMIPIYRKRTTIDSSGRETETQTRYFVVDSTEALAKFGTDAWDRVVCVLTTGQAWQFRPYKWTEPKTLFHHVKGIYFSWTNDPPNPKIKDWNVTELKIDPHRRHVDKSVVAHFWKLLDQWTSTHKPSLVQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MA33</accession>
    <name>A0A4Q9MA33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_977645</name>
        <name evidence="2" type="ORF">BD311DRAFT_107060</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143517">
        <property type="protein sequence ID" value="TBU23048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MA33"/>
    <dbReference type="OrthoDB" id="2757482at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU23048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18058" checksum="096E8A8D01F58A8A" modified="2019-07-31" version="1">MAPVSICVADRPKPVTSLALPSPPHSSIPAAVGGVIFGVMFIALIAFAFYYANVCQYESNTSTPGHRGDFFRNMRSAVSFQPTAPIFPLSVRTDAILRTLNFHTAPRTPTPRGSRTGYTIPPPYEHPPSYETSISDHRGSVASPISPFTQCPAPSEHLVMESAAGPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MDN3</accession>
    <name>A0A4Q9MDN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_961149</name>
        <name evidence="2" type="ORF">BD311DRAFT_764846</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143463">
        <property type="protein sequence ID" value="TBU25339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MDN3"/>
    <dbReference type="OrthoDB" id="2758276at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9501" checksum="C45CD61F48BD8673" modified="2019-07-31" version="1">MAFAQFYYDPAVEFERVLDEHAHTQGASNGGIANADENTVGDASGLHNIPPSRSQSVGTIGERASGQSKDTLNRRFVDTLFKWRDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MGC9</accession>
    <name>A0A4Q9MGC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_831134</name>
        <name evidence="8" type="ORF">BD311DRAFT_667628</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143446">
        <property type="protein sequence ID" value="TBU26399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145230">
        <property type="protein sequence ID" value="TBU52968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MGC9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MGC9"/>
    <dbReference type="OMA" id="LNQACNP"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000061">
        <property type="entry name" value="TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII28-like protein" evidence="7">
        <location>
            <begin position="26"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU26399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU52968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="133" mass="15106" checksum="B9B97FD710B9F36C" modified="2019-07-31" version="1">MLPAMADDDYSAQLSWQSQSKDNLKVLMDNFSPQQYDRFEAYRRHALPKQAVRKVIQGATGQQISQPVAQIVAGFSKVFVGEIVEKARQVQARRGDTGPLSPDHLREAYRMYQEETGRVGAARPLRGKRLFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MQU7</accession>
    <name>A0A4Q9MQU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_806578</name>
        <name evidence="10" type="ORF">BD311DRAFT_660936</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="ML143412">
        <property type="protein sequence ID" value="TBU29577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MQU7"/>
    <dbReference type="SMR" id="A0A4Q9MQU7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MQU7"/>
    <dbReference type="OMA" id="KEYCFLS"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU29577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="510" mass="57667" checksum="1BF911CF9112286D" modified="2019-07-31" version="1">MASDSLMPRSESFNARVRGASHIDFKTSTTGVAAKAMRNELSALVNTVKDPETRKAFDTEMQSFFYLFTRYLSERARRQELDWDRIKSPSEDKIVPYAKLPSGPANNLNKLAVLKVNGGLGTSMGMTGAKSALEVKDDMTFLDLTVRQIEHLNTTHRVDVPLILMTSFNTHEDTLRIIKKYANQQLRITTFNQSRYPRIFKETLLPCPRTAEDDKKHWYPPGHGDLYNALLHSGVLDQLLAEGKEYLFVSNSDNLGAVVDDKILQHMIDSQAEFIMEVTDKTKADIKGGTLIDYEGSIRLLEVAQVPNEHVEDFKSVRKFKIFNTNNLWINLRALKRIMETEGMELDIIVNPKTTDDGQAVIQLETAAGDAIKHFNNAHGVNVPRSRFLPVKSCSDLLLIKSDIYSLEHGQLVINPQRMFETTPVIKLGDHFKKIAQFQKRFKKIPTIIELDHLTVTGDVYFGRNVTLRGTVIVVANEGQSIYIPDGCVLENRLLSGNLNLIFLILFQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MSL3</accession>
    <name>A0A4Q9MSL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951720</name>
        <name evidence="1" type="ORF">BD311DRAFT_776577</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143403">
        <property type="protein sequence ID" value="TBU30860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MSL3"/>
    <dbReference type="OrthoDB" id="2749208at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU30860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="28769" checksum="E0E8099F757F3CE2" modified="2019-07-31" version="1">MIGTMGSTALADTRDARCHPRPVQAIQINDLDVMDFAELFPEVLLQATRAKASHLALSLDPTLGDDCSRQLVLSARGPEGTFHISTDTFEDSAYAQFDWDDLRFVLSAGQHLQAMREVWITGIPPQNNNTAAFKSVIAALPALETIVFVITQVTSETGVDAIRASPPKSSRRCALHTATTLTSLRRLLERVETGAYGYFQTLILQMTGRLVVRKGELRRLQARFATVTFEHIGQMPTMSLPDYCVEPYAGPGGSSSWPGSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MYG8</accession>
    <name>A0A4Q9MYG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_236527</name>
        <name evidence="6" type="ORF">BD311DRAFT_688918</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MYG8"/>
    <dbReference type="STRING" id="114155.A0A4Q9MYG8"/>
    <dbReference type="OMA" id="HDQFFGN"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597595" evidence="4">
        <location>
            <begin position="24"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="5">
        <location>
            <begin position="79"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU31386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="529" mass="58839" checksum="1F23E8DAC62340E4" modified="2019-07-31" version="1">MAVSVWLTLLASIPLLFYLYVRANDAKIAQLPPEAVAFSPKRWTSEDVRQTARSAALTSPSVSLFSPDELPPKTGRRYVVVGGAGFLGGWIVLHLIARGEDPRRIRILDIRRPIRQDLLEGPATQVDFCQVDISNAAAVEEAFRKPWADRHDDPEPELTVFHTAAIIRFYEREESLQPYSDRINVSGTQNIIAAARKVGASTFVYTSSGSVAVRSNRFFRWPWEGPPKFFVQPINDDDELVPKRHEDFFSNYAHSKWKAEQFVRGVDRSPSGNGVMRTGCIRPGNGIYGPGGDLMLDAYMHRKQNPSWIWNILQSFIYVENCSVAHLAYEQRLIELARGSTHPDIGGQAFCIADAGPPPTYGEIYRGMTELTGGEVTFMRLSATAMLAFATLIEAYYLARHAILRFPPPFSALAKLVPALGGDIVYLQPSMWSLTQVHLIFDDSRARASPAQGGLGYDGHVTTLQGMCKVVVEHKKNGSKTQKRVIAGHHTPDHHFDLTRAEKGVEEVIEKLGGGHKPDTKSQVAELQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N1U8</accession>
    <name>A0A4Q9N1U8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_596466</name>
        <name evidence="5" type="ORF">BD311DRAFT_396943</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N1U8"/>
    <dbReference type="OMA" id="TWGFAYG"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="428"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU33867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU56873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="460" mass="49742" checksum="EBE89AC9F39F2F28" modified="2019-07-31" version="1">MAPPVGVTGSDLTRKQWVYAFALVTSLFFTWGFAYGLLDVLNSHFQTVFGIDKTQSTLLQLAYFGAYLVFSPFASLFMERYGYKRGIHLGLSLYSLGAIFFWPSAKFAKYGGFVGCTFVIGCGLSCLEVAANSYISILGSPKYAAARLNFSQGFQGVASFAGPMIASRWFFLGKNATTLDTVQWVYLAVAGLGAVLNILFYFCPLPEITGDALAQEMHEAGILADEQPFLKQYHCLFGLVAQTAYVGAQVAVAALAVNYITEQGIGIDKSQASQLFSYCQITFTVGRFVGVVLLNWVDPALMLTIYSIACMTFALGVTYGPGKAGVGCLFSLFFFESICYPVIFTLGTKNLGRHTKRGSALIVMGVGGGAWWPPMAGAIADHISTAQSYVIPFSGYTIMGMYAVGMVISQARTGGFRFRTVDEIAEKRAELDHSPSPAGGNRESDSVTDKKGTQEFVEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N6H7</accession>
    <name>A0A4Q9N6H7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="15">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BD310DRAFT_915907</name>
        <name evidence="24" type="ORF">BD311DRAFT_682901</name>
    </gene>
    <organism evidence="24">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 464.89</strain>
            <strain evidence="24">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="15"/>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N6H7"/>
    <dbReference type="STRING" id="114155.A0A4Q9N6H7"/>
    <dbReference type="OMA" id="CYDRNDS"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 15" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="46"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="223"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="487"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="585"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="673"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="749"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1123"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="912"/>
            <end position="939"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TBU34751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="TBU63787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1222" mass="139021" checksum="772DD79F290A6769" modified="2019-07-31" version="1">MSQDFDATQSFYDDGYGVDGEVEDEYEEITQEDCWTVITSFFDQKGLVRQQLDSFDEFVQNTMQELVDENSDLILDQADQHTGHDGDVTRRYEIKFGQIYLSRPTVTEADGAVVPVFPQEARLRNLTYSAPLYIEMKKRILIGREDQEGSGDMVWEVQRDDDPEDTRKVWIGKVPIMLRSTYCILHELGDKELFDLNECPYDSGGYFIINGSEKVLIAQERMATNHVYVFAKAQPSPISFLAEIRSAVEKGGKTISQFQVKLYHRSQERSLGNVMKATIPYIKVDIPIWVVFRALGVISDRDILEHICYDMQDNQMLEMLKPCIDEGFVIQDREIALDYIGNRGTTTGLNRERRLRYAQEILQKEMLPHVSMAEGSESKKAYFFGYMIHRLLLAALERRDLDDRDHFGKKRLDLAGPLLANLFRMLFRKLTKDVYRYLQKCVETHKEFNISLAVKHNTITNGLKYSLATGNWGDQKKSMSSKAGVSQVLNRYTYASTLSHLRRCNTPLGREGKIAKPRQLHNTHWGMVCPAETPEGQACGLVKNLSLMSCISVGTLSAPVIEFLEEWGLESLEENAHASTPCTKVFVNGVWMGVHRDPVKLVSTLRKLRRKDDINCEVSVVRDIRERELRLYTDAGRVCRPLFIVENQQLLIQKKHIESLVRAKDDPTFNYNWDSLLKDGVIELLDAEEEETVMICMTPEDLENSRLQAAGIDPHADEEEDPSARLKAPTSAHTWTHCEIHPSMILGVCASIIPFPDHNQSPRNTYQSAMGKQAMGIFLTNFLIRMDTMANILYYPQKPLATTRSMEYLRFRELPAGQNAIVAILCYSGYNQEDSVIMNQSSIDRGLFRSIYYRSYMDLEKKSGVQQLEEFEKPTRDTTLRMKHGTYDKLEDDGLIAPGTNVNGEDIIIGKTAPIPPDSEELGQRTRTHTKRDVSTPLKSTEQGIVDQVLITTNAEGQKFVKIRVRSTRIPQIGDKFASRHGQKGTIGITYRQEDMPFTAEGITPDIIINPHAIPSRMTIGHLVECLLSKLATLIGNEGDATPFTDLTVESVSQYLRQKGYQSRGLEVMYHGHTGRKLQAQVYLGPTYYQRLKHMVDDKIHSRARGPVQILTRQPVEGRSRDGGLRFGEMERDCMISHGVAAFLKERLFEASDAYRLHVCDICGLTAIANLKKQTFECRACKNKTACSQIYIPYAAKLLFQELQSMNIAARLYTTSTGRIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9K9</accession>
    <name>A0A4Q9N9K9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_912208</name>
        <name evidence="4" type="ORF">BD311DRAFT_860444</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU36001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9K9"/>
    <dbReference type="STRING" id="114155.A0A4Q9N9K9"/>
    <dbReference type="OMA" id="ANTIAWM"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="86"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU36001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="388" mass="42857" checksum="1AC051E31CCDE0DA" modified="2019-07-31" version="1">MVLPFISKHPLLCKIPRTLPKCIPGIALSKQARCFASSTPSSSPPLPRPYRFHVGASWAGKPHDPRGPRVNTDPFPPDSPIGKWRDTTLSRPNPGAGKHIGEDFFYIQDMREGSGVSLGVADGVGGWVESGIDPSLFSQALMYHAHRYSKVAWPGEPEVDPMQEYEEREQVEGWELSPVECLESAYGGVLRERYVVAGSSTACILTLNASTGMLRAANLGDSGFLIIRGSQVIYQQRSQTHFFNCPKQLSKLPVAQKRFSRAVVDHPKDADLCELKLRHGDLIIAYTDGLSDNVFPSEMVAICGLVARQFQLNRRTITPVGEMEFEGSAEDQEVQAMAERIVDYARICMANTKRVSPFERAAAREGMYFRGGKVDDVTVLVTMVQEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NA91</accession>
    <name>A0A4Q9NA91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_938258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NA91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043388870" evidence="3">
        <location>
            <begin position="32"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="410" mass="43612" checksum="A126550BA34EF8A5" modified="2019-07-31" version="1">MRRRAAALTHLNAARWPAFLPLSLLIARASSLLVNVTVDDTFGDPTTGAIPQYLPNDPPGTIGAWHAGNATETDDWSTSHWTPGVLDLFEIHNQTWHDSTPQNGPAQVVVSFTGTAVYVYSVIPNMVFQTTTTANMTFAIDGSVLGNFTHSPDPSGEILYNQLVYSNTELEPATHTIVISAEGENHSFILFDYLIYTTESSDETPSRSSSQTSSSSSSTASSTVFVTTTVSPSSRVPLGAVLGAVFGGVVLLLATLIGAYFLLRRRSKPHSSSTSARAYPTGTNGSDRTEDGADSQSSTIAFATAPAGALMTQTQSTDSPVSQGASSFASPEPSKRQVVISRRIQTLQRELSMLSASSPSIRSGDTGEGTETVVRALETEVAALRRELAGFSSQLHGDRRTTEAPPGYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB13</accession>
    <name>A0A4Q9NB13_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_62930</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB13"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="43"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU54704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="321" mass="34524" checksum="DFE957631CDE7C2E" modified="2019-07-31" version="1">MFAFVFRRLSAFVAFYLTIQLSAVIAAPLEQRDLEARATPSAPHFVVYADQSQSGVTGPPAVSNVNGWNVFILSFWLLEGAWDKAEEWTQLSASDRATIKSQYNAAGIKLLVAAFGSTDVPTSTGADPVTTANNLASWVKTYGLDGVDVDYEDFNAMDGGTAEAWIISFTTQLRSQLPAGQYIITHAPVAPWFTPSHYPGGGYLKVNSQVGSLIDWYNVQFYNQGATEYTTCAGLLTASSSTWPQTALFQIIASGVSASKLVVGKPATTGDANNGYIDPSTLAGCISQAKNQGWNGGVMSWQYPHASSSWITTVRSQSWPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCM2</accession>
    <name>A0A4Q9NCM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_982470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145303">
        <property type="protein sequence ID" value="TBU51593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCM2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9040" checksum="84BBB16A140599F3" modified="2019-07-31" version="1">MFQPMYVTANPGNVAFFTSPRTITPCIRAHDSNIVVGTSTPARGTVHLVTIVGNKASIWPYIVNTCAEGCVGGIVVDGSCTKTLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEF0</accession>
    <name>A0A4Q9NEF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_926081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEF0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20101" checksum="50F014A895E752AA" modified="2019-07-31" version="1">MPRLDLGDTILSLPRIVYADFPLGRLARGFPNISACGLGPPSTTKLCHIAEVLSLSERLGLARSRLCFHDQCLCGALQSIREHICSLVHFWRDGDSYSGDCFCCPNAPLPIGSPRRDSECRAHNTDLTTKVRKSRPSTRSSTRALSTHHTVKAWYVLLVPDGLCMPWPSPFPLVCLQTVSVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIL4</accession>
    <name>A0A4Q9NIL4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_808844</name>
        <name evidence="5" type="ORF">BD311DRAFT_763990</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143456">
        <property type="protein sequence ID" value="TBU25711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIL4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIL4"/>
    <dbReference type="OMA" id="RCHKCVR"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00349">
        <property type="entry name" value="Ribosomal_eL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047868">
        <property type="entry name" value="Ribosomal_L34e_arc-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU25711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12718" checksum="3B09C1FB4F7CEF2A" modified="2019-07-31" version="1">MAQRVTLRKRTPYNTTSNRRRVVKTPGGKLVYHHLKKLATAPKCGDCGIALPGVPALRPRQYATISKTKKTVRRAYGGSRCGDCVKSRILRAFLVEEAKIVKKVIKSQEKAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIM1</accession>
    <name>A0A4Q9NIM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_957853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIM1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIM1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="291" mass="30703" checksum="F8C16B4B667F0235" modified="2019-07-31" version="1">MSGLSHLLRVDDTSSRLVYNGSWAPGSVSDGVTIHTSTSAGSTVKFAFNGTFVAVYGVIDGDSVTASFALDDLPPVSASVPQPPGSTTENWPFFSTNPPLDPGLHELTVIINDGTFNLDYVQYVTLPGHSDSPGDSSQVQATSSSSTSSSSTSSLIPAHSQLTLGAIVGIVAGAVLLLVIVAVAVFVRRRSARRVRHVKLDSEKPVDIIYDNAPKSPPVAARRPLRRFSLSRVYRPTPPRSTQSSKTATSSAPTSITQSSAMFTSVIMLSPVLSMVSEESGHPEHDTSSYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJS5</accession>
    <name>A0A4Q9NJS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1031907</name>
        <name evidence="3" type="ORF">BD311DRAFT_760307</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143431">
        <property type="protein sequence ID" value="TBU27547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJS5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJS5"/>
    <dbReference type="OMA" id="NMDYDKG"/>
    <dbReference type="OrthoDB" id="18139at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012098">
        <property type="entry name" value="SND3_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28112:SF1">
        <property type="entry name" value="SRP-INDEPENDENT TARGETING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10032">
        <property type="entry name" value="Pho88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008756">
        <property type="entry name" value="P_tr_PHO88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU27547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20355" checksum="97AB1351F83D0CCC" modified="2019-07-31" version="1">MNPAVQNLVISLGAMQLAKRVPFDDPQVLTYVRIAYVATQVLVLGVYYYTGLQIKKKNDQTVLKYVEPNPMDPGANKLVTTTVRDYDLQETSKLMRAVYFGVAMMAFMHLYMKYTQPLFIQALMGLKTLYDAKPVAIHVLGKPAEGDLKRPFKAGGMFGAASDPQTDKAAIDEAEKKVGKKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NK38</accession>
    <name>A0A4Q9NK38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_684512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NK38"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16397" checksum="FEB1822F3E3987BD" modified="2019-07-31" version="1">MIVRHDGLLSIARHPSAPFFPTPVINPHEWKANVLRISCRSVCCFLSAACAPGMLADALHPLPSLPGAQNTTCDLFRKDQSMKVVHITIPSRIPYSHISLAHLRFLAVLLSISHAFTRESRSAFCPPVSSLRLKLSCTTTTYHLSRSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLH9</accession>
    <name>A0A4Q9NLH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_910272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145266">
        <property type="protein sequence ID" value="TBU52096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="327" mass="36942" checksum="878F563F16448512" modified="2019-07-31" version="1" fragment="single">ANPDSGSAAHSWSLLLLNELFTFNPAALELMPWKAVRHVAAATELQLRQLLHPSDGEPAPERDSHVVFRSMGILVRCCFAPVPSWTRSQEETKASMACIFGIYVPWDRSLCDELTLRLWEDILRYDPANLEVIPWKLVRPVVAVAEMRLRQLLHPSDGEPSQEPDWHVVFRWLWILVRCCFAPVSSWTRSQEETKASMACIFGMNFLHKGSISKIAGQLWSSFAIGAILETLDIILTYLCESEDVRRGASGDFLNAVGELVKYVEGATLSYSWYDDDVQEALKKLKRSMERCKFLRLGVQAEEVRMQASPLDTKPESSAIGEHPEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMW3</accession>
    <name>A0A4Q9NMW3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TFIIS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_918047</name>
        <name evidence="6" type="ORF">BD311DRAFT_748360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IWS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMW3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NMW3"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="5">
        <location>
            <begin position="203"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU33321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="380" mass="42744" checksum="F2F6A8B826C2E97B" modified="2019-07-31" version="1">MSEREAKNSEDLAAAIFGHSDSDLSSDEDDLDIPQRGGSPAGEESSGGDSADDYVQQKKRVPKTKKKSKARRGEDDEEGMGSSQRKRKRASKKKAPEEVDLSQYPPEVASKMKLDMQIEAILKPKKGSRPKRKRKDDDDVLDRFADEEVSRLREAMLTAAADDDQANREKLPATSKLRLLPQVMDVLRKTSLAQSIVDNNLLEGVRRWLEPLPDKSLPALDIQKEFFPILKKMEFIDTNVLKESRLGRVILFYTKCKRVTPDIQRAANDLVSIWSRPIIKRSASYRDRVIPIAQMDAEGGGARSGERLNAILARAREDDKGRVRKNAVMIPQRELGSYTVAPRANAGLSRNNVPVDVDIQRRKQNAERLKSLTRKLTSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NP31</accession>
    <name>A0A4Q9NP31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_601279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NP31"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="394" mass="44296" checksum="60ECB8F382BC4361" modified="2019-07-31" version="1">MPHSVCHTLLDGGHMRCSAAVRSGRQSCGKHAAEYDASYKRYKSAENDAKLLRAAAQTKHSDVHTLPASEIEPRIKHVQVYSDALELELTLRRQHDAYFIGDPDEGHRRRLQALEQQIKHHRDVLAALHARLEMMHPAVKRTSQRKRRRGSVAEITAQSAPRVPQPQATSHHSPKRYRPAQSNRGRDERKKFEEGHQPRSTTPALGSQKRALVVRNSLGPRWTERCRVTEVDVMRTGDQSRQDIIAEVSPDVGVVRNEQEERATHAPEDGGPFSEGADPPCQMARALRALRTPSSPTIQVDTNEVTSSPSRLRMPGEYIPTDHEGAHSEHSGGDSERSHGLPEHGRRYLHYALAAILQLAVFALIRKFYIGNVRKDLWPMITRMAAVLRRPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQ42</accession>
    <name>A0A4Q9NQ42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917017</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQ42"/>
    <dbReference type="STRING" id="114155.A0A4Q9NQ42"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="37161" checksum="AB703C5DB4B526C7" modified="2019-07-31" version="1">MAESTRHMPECWGHRGASAAFPENTLASFERAIRDGAEGIESDVHVSLDDVVIMFHDPTLDRTTDGHGKIKEQNWYGFKGMQYLRTLKGPQQCIPTFAETVELLMKPENRHVTFDIDVKVFNEPLHLFTLMHEVISTQPNWEVDLAPRILLGLWHPRFIPHAKTILPYCKRSFIGVSMAWAREYFWESCEVFSINFSILATWEGARFREECKQAGKKVAVWTVNDPAQMLEAVQWGVDVILTDKTKDWLDLRETLRTDYDKIMEGHSSTFLWTSPRYYFLSRKLWETLASYYLQKFGGPAKKVDGLEDTPDTAVPPGKAAAVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW04</accession>
    <name>A0A4Q9NW04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_573492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW04"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="222" mass="23529" checksum="FFBB2F1A0F0B8EC5" modified="2019-07-31" version="1">MHRPSIISSPAVKSRTGKRAAAYPSPLTYSSSLSHTVSSLASPRGPSYHTRPASSLVSTHILYGPLSGFTRPGSSTRIHHGSWVAAPIACTSIMPPPPHSILRRCTTAVQTVSLAFTDTPHPLPHISAPLALAASFPCIPASTRPYSNCLLCLLLGIVRLLRSSTIALAASDIPSDCIIVYHSFLSSVDIGCIVSLRPSSLTVFLCSGSICAHPRSRTFYLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYH1</accession>
    <name>A0A4Q9NYH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_815688</name>
        <name evidence="1" type="ORF">BD311DRAFT_674024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143506">
        <property type="protein sequence ID" value="TBU23411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYH1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU23411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5795" checksum="25F7FEA23ADA39A5" modified="2019-07-31" version="1" fragment="single">VRGCRWEAVGPERTDDGLSAISVAASAGFYTWRTLCTSRLEGEAGSRFPQSSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P631</accession>
    <name>A0A4Q9P631_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_868931</name>
        <name evidence="4" type="ORF">BD311DRAFT_746744</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P631"/>
    <dbReference type="STRING" id="114155.A0A4Q9P631"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="3">
        <location>
            <begin position="10"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU34754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="25498" checksum="061DA95CF7381D39" modified="2019-07-31" version="1">MASALPLTFNQAVRGTAEFIEVAIHTILYVRQVYPAELFVRRRKYDTPVFQSRHPALNEYIAGAVKAISDELALGHVDKVVVVIKSAQEQPLERFIFAVRNTLEIESYNKDTSVEGAISIAAMGQYFRSALVKLNMIEAQLGQMHLDDISFAILLELQDDKAPSASHGKDPPPWIPGASQHTTSAVSETAELHMVRAVDTGIINLALAVQESEHKLNLEKEPQAKGKEKAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7H9</accession>
    <name>A0A4Q9P7H9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_997029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7H9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF143">
        <property type="entry name" value="NAD(P)-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="338" mass="37089" checksum="2826CE0C1DAEBF76" modified="2019-07-31" version="1">MSSLLPDTLNPATLLCKRFRPDQIPDLTGRVALVTGGSAGIGFHNVAALAQHNAKVHFVSANPEHGKSAVQDLNKALQESGAKGSIHYHQLDMHELKRVDSWAKQFVEQENRLDILIANAGIGQAPFGMTSDGLERHFEVNNLAHYVIVLRLLPLMQKTAAKAPPASVRIVMQSSEMHRFAPTGTTFACKEEVCKDEDGTQLYGRTKLGLIVFAQELARRKLTDATQPILAISVHPGAVDTDLQKAWGQSYGVLGVAIDKVTRLAGKSAEEGAEASLWAAVSTDINQTNWKEYQGKYYSEPYGKPDTESNAAKDEAIRNNFWRLCSDLTQEILGERIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7W9</accession>
    <name>A0A4Q9P7W9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7W9"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7W9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="381" mass="42180" checksum="DEF6B2A7B447FEEA" modified="2019-07-31" version="1">MGRTRPKTRKIKPVITENTSEGPAPPPSISSLLEKAQSLIVQCEYELAGRFAQRVLQREPGNVEAKEMLGVTQLERGEILAAKETFQSLVPPHSGAPVAPPPSAYLYLAQLSDDDPHLALRHYQSAVDLLSNQLKGKERAVDPLSSKDDEGETKRNIVRALIGMVEIWMDPSYDLCDDPAAEKTCEDLLNLALQTDPGNTEALQALASVRMSQQRPDEAKVCLEQAWSQWKDLDLDDPQLPPISARLSVVKLFLELSLFTPALLVLQGIIASDDQDVEAWYLEGWCFFLMAEQAQENGGELGELTWDDLAHNARDCLDTCQILHVKQEHPDVPLLEHTRELIAKLESLGIQPSPEIDGDDEDEEGWDDVEGSDGDGDVEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8P3</accession>
    <name>A0A4Q9P8P3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_983134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145548">
        <property type="protein sequence ID" value="TBU50949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8P3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="17320" checksum="1595328E1C051757" modified="2019-07-31" version="1">MAGSTQTSITSSANIGNARDYIAVHIRGKERSRPQVTSTISPLSLYTLFNLALSPLLRRPPSPRPSPTTPVARPSDPVLQTYTVRFAHCRPSIRTPTIHLPPMQPEIANARRAPHPCTISLGCPALVTTVRTTRSSPDTVRNVRRQCGLPTQPWWPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA05</accession>
    <name>A0A4Q9PA05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_942463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145349">
        <property type="protein sequence ID" value="TBU51268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA05"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18847" checksum="1CED331D8BA50BC1" modified="2019-07-31" version="1">MLRKLQRFSRADIVDHFPSRTVFSTTTHREASDTRPLTHLISTERPRGLGRPSRRVIRTLDPTKLTTNDYLDLSSCCGPSLPSCYRLWTAPPLRRALYISCLLAGALANSTQRIGILIPPHPYSRPIARRRVVSPCYAVFRSRELCDWFRPCHRMRPTVEPSFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAL8</accession>
    <name>A0A4Q9PAL8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_316597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145289">
        <property type="protein sequence ID" value="TBU51740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAL8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12852" checksum="F84EC3B8536B95A8" modified="2019-07-31" version="1">MSACPLRMAAIVSPMLGCATPGRIDMFGRESRMRRQQLISRAKTGRRVDVNRAWPEAGMRLNDLRIAVLSTTTSPPTVLRNMFAAVVSVARMASVREKDGPRVSAVPWLVLSVGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAY5</accession>
    <name>A0A4Q9PAY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_945377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAY5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAY5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="512" mass="54403" checksum="4EC4591C48171E14" modified="2019-07-31" version="1">MPTATATTVASPVIPLKASHHAPATSSSTATTLRSLYPRAARAFLQRDILLTHSLLASAFALIHPPASVSTQNDALASARRKWDILRITFETTLFSSPPSSQDPEHLPSALKANLTLSPESLITTLHARSLQLFTPSDHAQRPSSAFLPAQILVTLVLASLKLDSTEVGRGMIEDWLAKQGQETDGDDPKGYAKVLELYCLHVLPRLQDWEYAEDFLTYERDLPGDVRQQYVQSLRQLRAQAATASRVQVTLPSPSSSSASTPSRSPSPAQSDSSASSSSTHTATPTTNGRVSGLAPLTPSHTPTPKPGDTLHPYTPPHSASSSSIASTATSRTVTPHNADRSRERERAKAGKTRRPANGHGHTNGHANPAVNAKSRSRSHSTTPAGSSASVVRRTPFGPPIAESPARPPSTLALVRASLGSLLQGTSRSRMVLYAVLFVVVPLVSFVLRLRRRRAGAGAPASAGSGSGSTVDAVRRRLRGVDGQGNVVGRLWEEVARAVLDTVRMAGRGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBT2</accession>
    <name>A0A4Q9PBT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_257756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145263">
        <property type="protein sequence ID" value="TBU52179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBT2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="43"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="646" mass="72747" checksum="90131D46B1789AC6" modified="2019-07-31" version="1">MLEIKSIDDIVHMSKASFVGCSPAALTNGTRTLATPPWAQSFPAELLARIFLHLRDISVQCYGYPRPSWLALTEVCWAWRQVALDTPGLWTHLVVYGLGYPGLLENILARSRGEYIHLVLKLFVPPNPSSRPQPSDSLNVLGKNLLDGFRAHGARILSLTVKSWAVNCWMLIRELVPSCTFSTLRTLSLEARPDNPVHVDFPRKSFPNHVTIHTSSVHLVLYAHDTSNILRTIHYHSDPVRLRAYASLFPQALKQFTDLTDLHLGYCGPRVTQNIPLHDIFLPRGLERLSIEDEPWEMQSVLSHLIFQNRTQLQAEDAEAGVMDIALQFLDLSVDLRQKKHYTACVLEDTLQAFKWWGVYSFVSSCSFARIDLWPNYALHMDAGTCSSQDTPKFQLAFKRGPEAVIEDIAANLIQNYCRLFSPVEKPEPDVAFSNLTHFSLHDGTGSLGRRLQWGPFLRGLPASVCSLALGNADLVRDFVNALQDLAKAAPEKTCRARKSVHFNEICCCVHDSILSEQRLKTVTGILLMCRKRNVLNVDELILRLPVDASLHHQPGKSTVPRKFGRNCRVSAYREACDTCHSPSSVPRLPTDLAAEKADRATVCLSSNTRPPTSPSHWENIEQIWEEHIGDMAETFEDIDWTHMNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCH9</accession>
    <name>A0A4Q9PCH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1043017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145248">
        <property type="protein sequence ID" value="TBU52510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="365"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="825" mass="93284" checksum="7AA3BF05CC575B20" modified="2019-07-31" version="1">MNVHTCIIAGFESFQYPNAPKSDESNEGYTASEDQGYYDTPQDIDQDFLANHLRSPTTFVATHSMLADVAKIMDAVTDNAMRREAAASLLNAISKTLHGSLSPSTREKHRKRSRVPVGKLGHLTFFVNYCEKEERDAPELVGVYNADDLRGQDDVDGMHRRIPYHRIEALVEVKPDRRRGGHRQTVSCAHRHHAARPDRPAIYCLVIEPGWYQVIFSDPTGVVVSPRNEWTDLRLLAAYIYSHYYPPRDRHLWDDSVSWISGETPHQPPTWMVRCHGRSYTHGRLLFAGYPWGRRTTVFQVTDRQGGEIIIKDTYRRRVRRWKEQDILVHIHEDGDLPGVVRLTWAGPVRTGNKMLTYGARGDEEARRKERMVLLDSGCSLVRAKTVNDLLEAIYDVLEVHRTVLRERKVLHRDMSINNILMYPKRADVGGRAMSRKAPIFIKDVLGGSQRPRTERLPACLVIDYDYAAQIEDVDELKQRTGTPLYIARSVSLGMVLIDLASNFGTPMPTLTGDALHLYTTAYGQERYDRYNEDPVARTCHGGCPPTRDSEGELELPDLPAFVHRPEHDVESVYWTMIYALLRAQPATAPRELDLSAASASVWKTLLSHYIPGEKYARSDEKRHEVMSRTKQEWLDLFHATMEDVALLLWRITLHVRAEYALWNWEGNPQPDHLHEAVQRLIMQYLVDHRDNPIQLDPDHLRPTHPRSTNQGDTPTPTQLSWTQANGVTGNHTASRVGSRRAASGNQGSDEGSRHTATGKSAAKGATAVGGPSSKSKQPRDQAKASQPVPNNCELEAQAERQEAISQQQASEGSLRCSHVPHVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD85</accession>
    <name>A0A4Q9PD85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_939387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145236">
        <property type="protein sequence ID" value="TBU52810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12940" checksum="0607AA8C14C7F03F" modified="2019-07-31" version="1">MHRWSHVCGWCLQSPTADSAALRDCECAQDPNRTARSRRKKSKRNEIIVRASDVSVGRRHERPRCGRTIICRISAEGRRGLLLPSLMTPPLSGEVPTVYSRRFWPLAVGRSATNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD93</accession>
    <name>A0A4Q9PD93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_834965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145362">
        <property type="protein sequence ID" value="TBU51207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD93"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12644" checksum="0F9A4FB0B5F2C44A" modified="2019-07-31" version="1" fragment="single">HMSHLPVSEAGRSRTPQGPGFDPGSSTFRYDLSVVRMSVCPGSHDPQVTWHEKTVTGGHNSSSRCPVSPPSRYPAICGLLASKRGVWTIGLYPGQCLGTDSSSSDQSGMGPVLPVHLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE33</accession>
    <name>A0A4Q9PE33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_953365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145359">
        <property type="protein sequence ID" value="TBU51221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE33"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="68"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="754" mass="86073" checksum="0C6B1AF4D8AB0D2D" modified="2019-07-31" version="1">MSRCSRNPCETTSKFNSKLSVAIFSGQHTRTGEPHHWADQVVPVQFARDELGADLFDHCDARDIPEEVEDARKESFSRICSAVEPLFTSQHRVFVFMLFVCGRRFRLLRWDHAGLVTTPSADYYENHSLLCDFLWRVAHLDDTALGFDPSATRVLPGDPDYLRMDLAARHDPSDVDHAERDLHWGELEEPFVFDYVRPFFRASIATEWPRFRLQVSSGEMARKFLVGKPVFMAEGVSGRGTRGYIALDCRTRGFVWLKDTWRLSYVNFEKEGDILSRLKAAGIDGVPTLVCHGDVGNQVTVTGDWRERTHPLPSSTSPSSSKTNMSTSRPSPRSSSLDNRKRKWRDVVDDDVSDSALGEPSPQAAALSRCPLRQHTHYRVAVKEICLPLTEFKNGKQLVKIMLDCLRTHQQAATHPGVRLLHCDVSSGNILIYPRLRKTTDGTALELSRRIDEQMPPTATLKDRIGTYQFMSVNLLQRPSEYPKIADDLESFLHVMVYNDVRHLHSNCNDPVWWVTTYFNHYAGPGRMHTCGQKSVAIETSGRLKTLSPRGPLFFYSPMDGLCFNALQSFRARYKVMEYEPQAGALPCPFPPRSPPRSFRSLPASGDTHVYDRARSIGIDEKIIAQIEAEWDTWMPPDDSPTVEDRRLAEKLLDHQFMIELYEKVLGNPRWPEHDRITQPQPLSRETKMLTTATAVAVAEYHKRSTPAEPPRNKRRRTTKTQKNVSRPPRLQETTRRTRSQTRKKALTHPVHAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEN8</accession>
    <name>A0A4Q9PEN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145321">
        <property type="protein sequence ID" value="TBU51441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEN8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33003" checksum="A4A01E662E693ABD" modified="2019-07-31" version="1">MATLDSLKPRLYHLAETRTKHFGSAEDVRYVTLFVNGMSATFNVVLPTTDIILALTPEQEIWQCLELAEGDSLRACDISEGQRRVVLKILYAYYACYFQNGITPADTKLFFRLVAEAAMALDDHEPADVVLEDLVDYIDGTFPSDSLVSILSTVYRPRLTITCTSPPPATSVSPLSDVSPAIAPLGHPAPAPTIAGMRIQPPRPLPKRGYAARPVSPVHRSPATISSPASLLSPSALAAEMTLGNCVPLHVPVSQDNGWESDDSLPSLESVAGSDSGGEEPYILHRGSYESVLGDIEDLMASLVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PET0</accession>
    <name>A0A4Q9PET0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxymethylbilane synthase</fullName>
            <ecNumber evidence="4">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Hydroxymethylbilane synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_938052</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="4"/>
    <dbReference type="EMBL" id="ML145214">
        <property type="protein sequence ID" value="TBU53440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PET0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PET0"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13645">
        <property type="entry name" value="PBP2_HuPBGD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000005">
        <property type="entry name" value="Porphobilinogen deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="entry name" value="Porphobilinogen deaminase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557:SF0">
        <property type="entry name" value="PORPHOBILINOGEN DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="Porphobilinogen deaminase (hydroxymethylbilane synthase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Porphobilinogen deaminase N-terminal" evidence="10">
        <location>
            <begin position="10"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="Porphobilinogen deaminase C-terminal" evidence="11">
        <location>
            <begin position="236"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU53440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="38300" checksum="764E3C415C6FC653" modified="2019-07-31" version="1">MATTESPRMITLASRASQLAQIQTNIVRDALSAKFPAQPFETSFMSTGGDQNQSQALYLIGGKALWTKELEVALKENAVDMLVHSFKDVPTVLPEGCEIAGVLEREDPVDSLIVKKGETWKTLEDLPDGSVVGTSSVRRVAQLKRKYPKLVFKDVRGNLNTRMAKLDAPDSPYAAIILAKAGMVRLGWGDRITSDLGPSTLLHAVSQGALAIEIRADDEHARALCRSIIHWPTEWRCRAERALLRVLEGGCSVPVGVHTSLVDETPAEGEEEGEHQARLSITGSVTSLQGDRHVQHSIEAEVRSVEEAEAVGARLAKVLIDTGAKEILDEINEDREKKIELAKTTDQKVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFN0</accession>
    <name>A0A4Q9PFN0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_829635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145208">
        <property type="protein sequence ID" value="TBU53658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFN0"/>
    <dbReference type="OMA" id="WDTSAIP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020251980" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="47"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="173" mass="17825" checksum="88B1736B7F1C3E6C" modified="2019-07-31" version="1">MFASTKFLAAFSVLAAAAAAVSAAPAKVFEPTNGNVDVVFRPHITAPTAGVVWQAGSSQTITWDASNIPAENQNQTGLILLGYIEDGDVNEHLDIQHPLAVNFPITAGSVTVNVPQVPARDDYVIVVFGDSGNASPKFTITNSTTSASSAVQSATSFSIPSASSFSFPALPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFN9</accession>
    <name>A0A4Q9PFN9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Brain protein I3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_937601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145208">
        <property type="protein sequence ID" value="TBU53668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFN9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFN9"/>
    <dbReference type="OMA" id="SYNMQPP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="14654" checksum="A48F19825F0AB4E3" modified="2019-07-31" version="1" fragment="single">MIEEKAPPTYPAYPSQPQAGYHPQGHSAPIPSNPSQQFMAPPPQGPPHQQSFQSGYNSAQGVGPIGPQSGYPPVSTIGLNPGAQYQQQLFAMCAQGNHDVTTKYGIGGIIVSVVCFPCGLFALLCDQEKRCVRCGVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFP7</accession>
    <name>A0A4Q9PFP7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFP7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF89">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="27224" checksum="509EFE09A43B077B" modified="2019-07-31" version="1">MATEAPPDLASTLSPEELKAIIARGYDTIAPQYLAWSGPRPTMTRAAYVAQLLDLLDPGASILELGCGAGVPTTQTIAAHPKKFHVTGVDISAAQVALAREHVKVPEEERAAEEERVREIGRGRVAFEHADMAKLHYEEGSFEAVLAFYSIFHLPREEQPAMIGKVVKWLKPGGYLLLNMNTKDEVVHREDWMGAPMFSFGIGLEGNKRAFEEYGKGLKILVDEVAVEKVGRFEETFHWFFAQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGF1</accession>
    <name>A0A4Q9PGF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_940590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145258">
        <property type="protein sequence ID" value="TBU52292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGF1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="142" mass="14968" checksum="3E623DE4826E4C7D" modified="2019-07-31" version="1">MGTQQSRSVHSVHLRRKDKRSTYSDTEGRRSGEGASGHRYTSAHQPQKQAVDREKSKTSETGWASSATQLAPANAAPPSDLSQPEPHGLAGNHATTEGTASGDGPEGRGDADRIGPLLYVPPCSSPSSTIRLLLSASPFTFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGP5</accession>
    <name>A0A4Q9PGP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_937492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145207">
        <property type="protein sequence ID" value="TBU53685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGP5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="21181" checksum="807DA500A0281F41" modified="2019-07-31" version="1">MSPPTSTSNSRIHRCRFVLDQNRRHQHTQSLPVFVRRRNRCHQCAVIRRAGPRCLRRRPARMTRRILPCHLLLLVPRRITHSTSIGAYRYLRRERRASYNSFTTSRHLCTTSGTCETERPDAGASEDLHEQAGGTRLVAMLFEAKIPRFPLDTIWGPPRDEDLRGALYVPTDQSFSPEKTSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIW6</accession>
    <name>A0A4Q9PIW6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_989840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145199">
        <property type="protein sequence ID" value="TBU54013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIW6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="17409" checksum="B83F4E9C0DDBE496" modified="2019-07-31" version="1">MPYEGFLGSEGSRFYRQHTSDIHYYNYLPPGLDPKVRQRASAIAQGLTFISAERHVAVQLKANGWPIHEVWVPSYHHFWFVRVFIRGPSQPGWFPPWPQPVEEQAAWAWVGGQWRPGHPIRWFYESIQWQMDVDGVPIPLFYHEHER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIX2</accession>
    <name>A0A4Q9PIX2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cyclin-dependent kinase 8</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BD310DRAFT_886830</name>
        <name evidence="23" type="ORF">BD311DRAFT_700084</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 464.89</strain>
            <strain evidence="23">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="ML143459">
        <property type="protein sequence ID" value="TBU25551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145199">
        <property type="protein sequence ID" value="TBU54020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIX2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIX2"/>
    <dbReference type="OMA" id="YFKNGGP"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07842">
        <property type="entry name" value="STKc_CDK8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 24" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="22">
        <location>
            <begin position="29"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="355"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="389"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TBU25551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TBU54020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="431" mass="48260" checksum="BC814C5C581D8C2B" modified="2019-07-31" version="1">MDHNLLVSDPMRLYRAKRDSARKRVTDKYTILGFISSGTYGRVYKAQSKDVDGRIHAIKKFKPDKEGDVVTYTGISQSAIREIALNREITHENVVALKEVILEDKSIYMVFEYAEHDFLQVIHHHSQTLRQSISVAVLKSLTYQLLNGLLYLHDAHIIHRDLKPANILITSSGVVKIGDLGLARLTHQPLMPLVAGDKVVVTIWYRAPELLLGAKHYNKAVDIWAVGCVMAELASLRPIFKGEEAKLDSKKNVPFQKDQLLKIFEILGTPSEREWPKVKDLPEYDGMKRLDHYSNRLQEWCQSRMPNGAQLLKELFAYDPDKRLTAGEALQHRWFREEPLPTRNAFVSLSAERVPPHRRITQDDAPSMMPLGAGGSHVQGQVSQMQATAQAHLSQQLSHSHSNQSGKAGSAASFASVSGGGGPSRKKARLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ44</accession>
    <name>A0A4Q9PJ44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020652661" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15083" checksum="FCB04815A1E5FACC" modified="2019-07-31" version="1">MLWNGSVLAGLSIVHIALTALEIDAIFIDDSYANPFIYPISSILVCHFLLNLRQVDVDPASESHSQSMSADDLRFAAVSAGTLPRFIASLGEPVHVYEPESVDAIYDASDEGALDDLVRTQAGDCVADQGDRLGSITEETG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKQ1</accession>
    <name>A0A4Q9PKQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1041597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKQ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="726" mass="78246" checksum="0511CEE576377E1A" modified="2019-07-31" version="1">MALAVHPPPPGDGPRRSTRIRVRRQTTLSRSSYLLTHTQTAVTRRPSISRSPQGADPSVIVASFTRQSKSGVHAASNHPSRKRHSYHHTRIRVSSSDTSTASSSSSGNNKLSARKQISLLVPHPDSATPVLAGTKRKRSQNPADPVDRLAYQLVSVDKHGDSVFQTPRQLRYAKRQRLLTSLSDNESPAAREPPAGRQRGTHRATTEGRLLSAIAPATPRPSESPASDERLRPDRPPTPRPKTPAHPVPDVVPNTEVAPLPAPSFTERPAHSVAPNTEPEEAAEPTICPFHRLKLPHRERRPDTADTGLWKLACQERVEYLKDTYREIYEAVIHAEALTAQRLYPQAHSTASDSDVPPSPVASFTLYTPSSCAAAARVDADGDTDMDAGYSSDWDSDEDEEEKSEAEDDDLLFDAHAQTHDDGLHPLDDDGGAHTGWSPGAQAFGGAPRLPRLATVPVYALECVPEQTARNGVPFMGRGTPVDRARRADWAAPAVALLPLSRAMGFAYQPWLRQATPVQVASPPQEFYAPHPQTQTQMLYPDMGLRFDPMQMQIDVQAPVPVPMPMQMQYAHAECMPWLDPALRAESSSPSPSPAPPTPTPAYALPLSLPQQQDFTMALPEYPSTPSLGTSPSPGVSLSPSLPSTPASPTGCAWHASFLQCLQSPTGCAPCFPPASSIASIAYAGPASPTPQHCAPFAAQAQTLELAEFAPPRLVEGSVTLGHALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLD3</accession>
    <name>A0A4Q9PLD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_718106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU54997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLD3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="25330" checksum="5E6433DF02F12C6B" modified="2019-07-31" version="1">MPSPTMVASFRMLSSQRPFLRHIRHTPHWPGKWPTVSHARQLTTGSRELEGDSPQPERPKRRQKLRKIRTLDPTKLSPRDYVDFSMLRQPNVELVAQSSDLNDASNALLGRLSATINARGIRDGKFPPNTAGFLYYHTPPYSPPLAGEVRFRITPSPDTASLSEGNDLLTEYGIPWKIPLLHMTDKKGYTGLQTLLLRDGLVTPQLLDIATSISKSVKTLSRIVGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLJ9</accession>
    <name>A0A4Q9PLJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HlyB/MsbA family ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_979944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLJ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="395"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="683" mass="74818" checksum="623B7F331433D639" modified="2019-07-31" version="1">MPTVEESDATLDIEIQTGVTPAAGAEPYADRVVSIISRFKKSCADLAGCFPYVVRMFKDVLSIPGCKSRLVIYGATELGLALVPAASIWVQGHLLQVVEVAVTTRTVDTELLLKICAGRIACTIANMVLGELHRCAQKTLNARIRRWFAMRAFEANARLDVPTFNLPSVQGQLAAASGGSYHSVVWQTMQMGMEIASTAPRLGSQVYALLRALRTDSDGRVMMLVTLLVETVSMLRDLSIFSTAETAIAVTTKSVEYLKMRAWDMIVKYKKASDVVGDNDGNWRDLRYESGASLSGRSWYAPMVFAHIPQIAFIVRAARDPARLPEALTELNLVQSAATSFAFSMYEVVAKLYQLQWHFSTIRDVYEVENIVNVVPDGTDALSEGVAQFTSGVALEFRNVSFKYPGTDQYALCNVSFSLLPGQLCVIVGSNGAGKSTILKLAVRLYDPEDGQVLLGGQDVRTLKLSDLRQAISVLFQDYTHFPLSIRDNIALGDPSKADDAEHVRLAARLGGAERFVEKLPDGFDTYLLRPAPDYVSGPPEGNKTLSGKPFDVCAVRAAAGIKASITPSELSGGQMQRLAVARTFMRSVVADDTKVGLLLFDEPSASLDPAAEHDLFERLRELRGNETMVFSSHRFGNLTRHADLILYMEESGVVESGTHDDLLQKEGEYARLWKLQAQAFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMR9</accession>
    <name>A0A4Q9PMR9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_933349</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMR9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMR9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU55553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="311" mass="33504" checksum="1008B64E61B1F54F" modified="2019-07-31" version="1">MGATRAQKELYFQKLKELVAKYPSIFLVNVDNVGSNQMHQIRVALRGKGIVVMGKNTMVRRALRSILGEYPQFERLLPHVKGNIGFVFTSDDLKEVRDIITANKVAAPARAGALAPKDVTIPAGNTGMEPGKTSFFQALGIPTKIARGTIEIVSDVQVVTAGTRVGPSEATLLNMLNISPFTYGMTVVQIFDQGNIFSPEVLDISDKELLDRFFSGVTTIAAISLALNYPTIVSVVHSLVNSYKNLLAVALATDYTFEGAEKAKEYLANPDAFVVAAPAAAAEDAPAAAAAEEKEEEKEESDDDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMS0</accession>
    <name>A0A4Q9PMS0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_979488</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMS0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMS0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="355" mass="39231" checksum="1F6C6C29544E7239" modified="2019-07-31" version="1">MADILAGLLQQFWELRVSVYANVASLALLVYDWQLTFGDEVNIMWMSKAKFSKLLFLWIRYFGIGTHTFIVGAMYLLPDPSPSTWFELLHDPSCRVATTFQIAGPNIMWWSVEFVFALRVWILYERSRKLLLFLAMVYTVSIGVSAVLLVKALLHVDFPNYIYGAFVIGNITTSMLCVLTLYQTIRFRDGITRSPLITLFLRDGLVYYFVVSVVFLLNLFMFRFGAATFKILFSGFLEAIPCMFGARVLINILSLVQKQSGVSDTAPPYSEPEFRHTSTAGFDSGAGVTSSGTDAGTSTSGTVTVDSGFGTGTHLSARSSSSGMTLSRGALSACAMGLEEVPRTDSDDIEKGYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN59</accession>
    <name>A0A4Q9PN59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_979418</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN59"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU55692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="516" mass="57475" checksum="D8CB25AFBD865BC7" modified="2019-07-31" version="1">MGVSVTTSLLTAWHAAAVILFLLIIRGAILRKRRGPMPPGPVGWPIIGNALDIPLNHSWKTFAKWGERWGNLMSVVLLGQPMVIINSYKHAYELLEKRSAIYSDRPHMVMAGDIVGWDQILVLLRYGNQFREYRRLMARVLGSRKSVEEFVPIIEEQTAKLLARLLREPASDLPSQIRKMTGSIVLMISYGYEPQENDDPLIRMADEATEQAAEVAQPGAFFVDVFPFLKYVPSWLPGAGWKRKGERYRANMDQMSAVPHQFVKDKMAAGTALPSFTSTMLAGSLAPDEEYRIKMSAASIYSGGADTTVSAELTFILAMSLWPAVQKKAQEELDAAVGHDRLPTYADVVQLPYLNAIYLETLRWNQVVPLGVPHATLEDDVYEGYFIPKGSIVCINQWNILHDPEIYADPFTFNPERFLSGHGKEPELDPRKVAFGFGRRICPGIHLAESSVLMVAAMLLSVFNIKNPLNEHGIPITPQTAEHTGGTISHPAPFTCTIEPRSDKAKALILALQERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNH9</accession>
    <name>A0A4Q9PNH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_1040936</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNH9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020256381" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="23"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="401"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU55766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1006" mass="108608" checksum="C8BE15ADE7BA2248" modified="2019-07-31" version="1">MLWHQCSLWASHALLLLSFVLSVLPVSLSIGAATLASLADPPRKSNGLSDVVQWDNYSLFVHDQRIFLHSGEFHTFRLPVPDLWLDIFQKMVAAGLNGVSIYIHMGATNPSRGVLDFNDWRALQPIFDAAKLAGIFVTLRPGPYINAETTAGGIAHWITSEVTGALRSNASDWTAAYQPYISGIIDAVVPNQVTEGGPVLFVQVDNEFSQFDTSEAYFADLEAQYRNGSVVIPLTYNDPGEGNNFINGTGAVDIYGLDAYPQGFDCSNPTRWSGVTTNYHSYHESADPAEPWYMPEFQGGAFDPWAGPGYDACEVLTGADFEDVFYKQNWAANVKLISYYMLYGGTSWGGFPFPGVYTSYDYGSSIRETRALGAKFDELKRQGLFLRSSPEFRKTDWIGDTSTGIPEVTLNGSAAFVTLLKNPDTSTQFFITRQADSTSTANISFTLTAPSSQGTLTLPPTTGSIALNGRQSKLIITDYSFGARGSVLYTTASIFFAGTIGQRDVLFLFGDANQSHEFALTLAGSGTRSTSTRLEFSDSTVGKGITNVAVQPGSNELLTIWDSPSQLILFADPVTAATFWAPAVKSQTRNTVPGFESFWQFGTNTTVLVGGPNLVRNATISGNTLALRGDLNASVPLTVVAPSAVKRVTWNGAPVSVQSSGALLTGRLTQNANVRRVTVPKLTGWKFNDSLPEIQPGFDDSAWTVANKTTTNINLQPLFGDGRVLYGCDYQFCEGHVLFRGHFNATGSETGANLTIYGGSGFAASVFINDQFISTAFNGGDHVNALFPFPDGSIIPGQDNVVTVVQDNMGNDEDSGEKSPRGIAGFSLNGGTFDTWKVQGKVGGYTNFPDKVRGVMNEGGLFGEREGWHLPGFDTSSWTARDISEGLPSGGAGVGFFVTTFDLAFPKDTDAFVSFQFETTNTQQYRALLFVNGWKYGKRVANRGPQTKFPVHPGILDFNGKNTVAVALWALNSTAVSPSLELVVDDVLDGGVGTVATNNPVWEPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNT1</accession>
    <name>A0A4Q9PNT1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_824790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNT1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021036417" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="32"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="555" mass="60118" checksum="278D25FAA24D0033" modified="2019-07-31" version="1">MVVIRTATYLLSLSAAAVIATANPHGESLPTVVLDNATVIGQPNGTTIKYLGLPFAQPPNGNLRLRLPQPVLPYNGTINATVFGNQCIQQTFPDVTLPSDVPAAAGQYLAAFLQPADVPQSEDCLNLNVIVPANATTQSRLPVAVVRGFQIGSNALEHGENVVARSIELGYPIVYVGINYRQILQRSQRSVAFGFLGGKEVKEAGVGNLGLQDQREAFRWVQKYISAFGGDPTKVMIWGESAGSISVALHMLHNGGNTDGLFRAGFMESGTVLPSGYVDNEYLQNTYDGIVQDAGCSGSNDTLQCLREVEKVLKAAMDKTPTFVGYQQVNTPYFPRADGVFVAQPSEQQLLAGAVAQIPLVAGNDQDEGTAFAFPTLDITTDDEFLEYINSNFYSNTPRDEVGKILELYPSDPADGAPYNTGDSFAYSPQYKRMAAFQGDFIEIAPRRLFTQYLAEKQPVYSYLSNFHKVEGIGAAHGTELADIFGGGPMQDYLIRFAATLNLNGNGAFTWPRYTNSSPALLTFNDAVPQLNITLDTFRAAQMEYLNKLSLADPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP55</accession>
    <name>A0A4Q9PP55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_932106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP55"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="589"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="628"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="658"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="809" mass="91085" checksum="EEBBF6A1B215D3D9" modified="2019-07-31" version="1">MDTERELVPTPDAPPRVRIGPRYLEVLALIMTDSPYYSEELPSAGPLPEKFAVDGDREKQLSVDKEHLVVADPEFDDPNIDPNALPLEDDSPYPEVRSAVANTDDPDMPVNTIRAWAIGLLWSIILPGMNQFFFFRLPGVTVTGIVAQLLAFPLGRLWAAFMPRVKIFGMPLNPGPFSVKEHVLITIMANVGYQSAYATDIVAVQRVYYNQIYNFSYQWMVVMSTQLIGFSIGGIARRFLVAPPSMIWPTNLVTCALFNTLHSQHYAGMGNRGGISRERFFIYAFSGSFLWYFFPGYIFQALSYFNWVCWIVPDNLVVNQLFGYYSGLGMSLITFDWSQIAYIGSPLATPWWASANVAVGFVAFFWVLTPIIYFTNTWYSAYMPISTRTSYDNRGLEYNVTRILTPESTLDLKQYEAYSPLFLSTTFAVTYGLSFASITATIMHTILYFRKQIWIQSRRSLSEQPDIHARLMSRYPQVPEWWYAIVFVTMFVFGVVAIEVWNTQMPVWALVLALIISFVYTIPVGMIQAITNQQVGLNVITELIIGYALPGKPIAMMMFKTFGYITMAQALQFTSDFKLGHYMKIPPRAMFWAQVVAAAVGGTVQLGVQAWMFTNIPDMCAPDQKDRFVCPSTQVFGTASIIWGVIGPQRQFSPGQIYYGLVFFFLVGALCPLAAYLVGLKWPNSILRYVNFPVIFNGTSYIPPASAVNYVPWTIVGFVFNYVIRRRHFSWWTKYNYILSAGLDSGVAISIILIYFALFYPQNGNVGLTTIQAWWGNVVSTKTADFGPGGAGTPFSALPPGATFGPKHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPG3</accession>
    <name>A0A4Q9PPG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">STE3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_637517</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the G-protein coupled receptor 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPG3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPG3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004934">
        <property type="term" value="F:mating-type alpha-factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14966">
        <property type="entry name" value="7tmD_STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000481">
        <property type="entry name" value="GPCR_Pheromne_B_alpha_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001499">
        <property type="entry name" value="GPCR_STE3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28097:SF1">
        <property type="entry name" value="PHEROMONE A FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02076">
        <property type="entry name" value="STE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00899">
        <property type="entry name" value="GPCRSTE3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00901">
        <property type="entry name" value="PHEROMONEBAR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0297">G-protein coupled receptor</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="8" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="374"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="377"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="451" mass="50179" checksum="33A102C7A49E9F1D" modified="2019-07-31" version="1">MVSPVDEAIITGSFSIFGACLISVPLYWHLEAWNVGCVIYIFWVGLLCLFNGVNYIVWRNSAIDFAPGWCDFYIRFYIGASIGVVCASLVINRRLYHIANVSAVSITRADKRRNMITDLLIGLGIPLLSIAVYWFYQGHRFNILEGMGCLEAYPNTWLALILYFLWPIPLGLVSGTYCILTLRAFFKRRRQFNELMASNKNLTFNRYFRLMGLASIEVMFTIPLTIYNIVSNFKQDPYPWRGFADLHSGFGRVDHVAAISWRSDSATVSLMRFRAWVPVALACTFFLFFGLAEEARKHYKMALSSVAKRVGITTFDRTASTGFSSAGSKSGFGKVTIPTFIQPNASMRRGSMDSFSDRLSTNISISEVEEKAAYSPGGSSVGSSTYISSPTDSEKAEKNAQPSPIALSVPTINFPKPPRAYRPASLTPSHEDRGEADVPSSVRPNSGIDMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSS9</accession>
    <name>A0A4Q9PSS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphatidylinositol-glycan biosynthesis class S protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_929171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSS9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PSS9"/>
    <dbReference type="OMA" id="AEHKYAV"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU57493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="532" mass="58770" checksum="A33DE777185E77A4" modified="2019-07-31" version="1">MATLHIDPTQLSFERPRTRRYIIASYWLVVLFAIPLWWKTTSIDRLSLPTSRVYAQRKREVSFPITVNLETKDGGNAAAIAREVQSCLRMDQAVQQGSAIDITVTSGDKSNASYNVVLNRGNHEPSAEGRRLYFDMYPEDDQLSHDTSVARLASTLSELLAPYGTYSGSAIQSQRVMKYAPRYRLAFTLLNEDAASGNGALAWDVQKAIQRHVSPLLNKLSVLHNFTIESQVQFHAPLAFEPRYIQQDGGDVHGLTHEDLTVFVNSAEWTLSSSASNDPVIHFVLFIPSSKHSPLHILEEDGVSVNPSNAFLLPQWGGIVLHNPSHPPSSTLNPLPRLALSDLDLIFNTFAYQLLTLLGVPGLPPRVQSVSAAEGAPPEPFTDWELDALLRRRAVENVWGSTETLESIVRLVDQIEGMPVGPDVKGDVQDALSALDDVHETSRSSPIAALKASARALTLSSRAFFNPGMLALLYFPTEHKYAVYTPLFASVAAPLVGAVLREIAAWRRARKAAQAQQQQQQERRPGERAKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTE7</accession>
    <name>A0A4Q9PTE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_537376</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTE7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="201" mass="22846" checksum="6DB64442CCC4A0A3" modified="2019-07-31" version="1">MLKTPAAFSDGCACRVSGYQNVEASKLAASARNGSAQSFLSAKIGVAYVIELCNGVRDFRRWQSQQVTRVRRLGWKSARADCFRHFARGWRHGRFKCPGDRTEHILWWSWEDVSCLMKSIQSEVQVWLSCSFWNANCPATTYMQARSTCRGAIVGILAFRFILLYLKGPSARAVRWHCTGLIHYWSSLNHSELHSSTFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU74</accession>
    <name>A0A4Q9PU74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1016628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU74"/>
    <dbReference type="STRING" id="114155.A0A4Q9PU74"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="260" mass="27577" checksum="F94F1FCF18872F03" modified="2019-07-31" version="1">MSSARSVSDATASPFNSSIPPSNAIAKPLSPKGITTEEFSAAAQRHSALFANQRYNLNMWSTLSREALLTLRRDSQVSSSAEASKRLHSPCLTIPRSHAATASGTQTLHLPPGPRHAPPPRLSLQDRAVLPAPHPLCSVLPLTPPTPANVAIKMAKRAEESIAPYNIGIGIYIKIPQMHGPSSSSSESPLPPPSQNNYTPRASHPSLPQLSPNSSPAKVDDSEAINSDLDDSDPDNAQEGIEGGTVDWSSHPCPGSMFHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW20</accession>
    <name>A0A4Q9PW20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_457059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW20"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="251" mass="27872" checksum="2983B9716B26A79D" modified="2019-07-31" version="1">MSARWPTRVFMEANERTANRPIPPAEFTVLVVARTLRYASALVPVLCHAARTLFLQYGDDKICWCCWSRLRNTRALLPQTDLEDIPKTCRPHIRMLSCQRTTTVFSISDSPSVPRAYSMRNVSAAPPIYAYSVIGLLGVVVGTYSVTRAQTQHYSSTPALARSDRAREQAPAQQKLQTSDIPCEEIPTRLVPASHLAHLSCSVAAQIGSSRTQWPVCGVDPASAEYPTREDPSANRVSCFRRACAEYAVWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWB8</accession>
    <name>A0A4Q9PWB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1012354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWB8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWB8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09076">
        <property type="entry name" value="L1-EN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19446">
        <property type="entry name" value="REVERSE TRANSCRIPTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="97"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="695" mass="77744" checksum="BBCF44AC6510E44F" modified="2019-07-31" version="1" fragment="single">MPPRDLGEGLSPPTEFGEDCPDDPRGREAAREPAQDTEGPGLSTAEDSDGGLPRAGGPSHERSETGTEIPPIRSTTQREARRLHASLAKKTAIRIASLNMDGFGSLTPDALDNKWGKIYSLMKLNRIGVLLLQETHLTTDRVNSLHKRFSSRIRIYFSSHPDSPTRKDGVAIVVNRSLVSTADADAVEIHPGRAIQLTFKCLGDVPTTVLNIYAPASDGIQARSAFFREVADEYARSPRLQKPQLMAGDFNNIEDAIDRLPMSDPPDNSVLALDELKLALGLMIADGWRATHPDRRAYTFHRQTRNRASLSRLDRIYVTQALFSTALEWDIQQPTLKTDHTLVSVRLTSENAPKVGMGRPVFPLRLLRDKKLAKSMHEAGLKAMKQLDNLESGSPRLITDNPQLIMASLKKEWLRLGREREKQIIPSIMSEIQNLEKAAASLSQKMHIPEDVRAGKVAACMAQAEHLKIKMVRQNQERARATHRMQGERPTKYWSKLHKKQEPRELVQAYEIEGQRSPSGEQCYQKDSQQMAEMAREYHDNIQQDGLDYNQTTGRDEEIDQVLRHIRPALDEEQGITLAEPVAPGEILVALKSTKNDSAAGADGIQYEVWKTLHERYIEDTKHEGRSPLNVVAMLNALYADIEVYGVVPGSAFSEGIVCPMYKQKGERTKIASYRPITLLNTDYKLLSKVLAARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWB9</accession>
    <name>A0A4Q9PWB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
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        <location>
            <begin position="124"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="309"/>
        </location>
    </feature>
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        <location>
            <begin position="398"/>
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        </location>
    </feature>
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        <location>
            <begin position="424"/>
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        </location>
    </feature>
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        <location>
            <begin position="651"/>
            <end position="728"/>
        </location>
    </feature>
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        <location>
            <begin position="741"/>
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        </location>
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        <location>
            <begin position="956"/>
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        </location>
    </feature>
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        <location>
            <begin position="1173"/>
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        </location>
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            <begin position="23"/>
            <end position="35"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="127"/>
            <end position="137"/>
        </location>
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            <begin position="431"/>
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        </location>
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            <begin position="893"/>
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        </location>
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        </location>
    </feature>
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            <begin position="956"/>
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        </location>
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        <location>
            <begin position="990"/>
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        </location>
    </feature>
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        <location>
            <begin position="1189"/>
            <end position="1198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1198" mass="126958" checksum="3955E884BE764107" modified="2019-07-31" version="1">MTATTMHFGPEWMRTKQGSSRPAPSPPLTSSPAPPGNSTYSALVTPASNPPPEGRDVAHPFRYSKEEMLRIYKEGGGRGGLGLEVERWEGIVREVGYEPVGLKEMSEAEKKLFAGPLNSEVRRRQSTDFLSPLNTSGLGERPKLNHVASGAGSPMRERIGSLMGRRRGDSTDQAPLSLPRKLSLSNMQGALASPREGGLPSPRVRPAFDGVLSDTWSARRRTSENVPKVGGKGDKETDGDSKDPDIKEEEEDALGASDQAKDPSGATSHAVNGNGTPNGVEMVNEQLGSMSISGQQDAQPQANQPNPAIGDLSAIEWSYLDPQGNIQGPFKADIMQRWYNEGYFQPTLLMKRTHLDTNWTPVGELILRVGEGQPVFLSPLALAVTPPGLSRPLENVVDRAIPERDQNSPYQPVPTRSIRSSTLDSYLQNGSNASDSPSSSIGGRFVNGSPDPSIFENRHGAQIGFDQLEQSRMPFATPGAAAIGTPGQRRATLNEPMEPVLGTRYGIGRTPGADGLSFSGPDSPGVFTENTFRQRIVQESGALNGLGGSSALNGGTEFGPIGGIHANHGTPSRVLNRDPFGRPPQDELQQSVGIGGSFSNHSSPFISHAPAAFPQTPLSQFAGQDNRSLHSITPDRQSIPYMPQHQQQFAQSPGFVNGQSPWQTHDVPAFTRRPGPFDANHPTSSNTFISSPVAPSHAFGRAPQMPVQNDQSAWRAPAQPVQNDSWGAPTASLTIANLGQHNEQQRQADLQRQSPRPAAGEPALAPERESAPAAEPQAQPQPDASTPVAAPSAPSPTDVAPQKPRRKSTAQTAPTASPASKVAPPPPAPAAPAKPPSPPPQAEPKAPWAIDDDKKKQGGAPTLREIQEAEAKKLEARKAEQRERERAERAARVSSQSEDFQPFTTSWGLPTSQAGARPTSVKESPVASPFSGSAPAPAAPVVWTNAAKVPVAKKTMKEIQEEEERKRKQAREKEKETVAAAARRAHVDTTTKPAAATPPSGGAWTTVGASGKVAAATPAGTARPVATPAASAKVVPTVSVVVAPSSSMSRPTTATAARPVAVAVKSTPSRDESASTLGPSLEFLKWLGDSLKGLNNSVNLEELTSMLLSFPLDPDPITVEIISDLIYASSTTLDGRRFAAEFVSKRKADATSRPKGASASSAAKPISIADVVKTQPKPAQNEWGGFKVVNKKKKGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWH8</accession>
    <name>A0A4Q9PWH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_948373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <begin position="58"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="97"/>
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        </location>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12275" checksum="83165C2F9E0378A1" modified="2019-07-31" version="1">MNPASAIIHTLVPSERSVPPVYPTLSTPASRPVFGQPHAAPFRAQLIRALLRSAYIRSGPRNRPSASTSHQEAVKRAPEDNVAADADNGRTQKRGPTGTSRTRALAGSSSHPSPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWR6</accession>
    <name>A0A4Q9PWR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BD310DRAFT_925769</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
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    </dbReference>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Tetratricopeptide repeat domain"/>
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    </dbReference>
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        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
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        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF11">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
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        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="601" mass="67912" checksum="7B9A0356C7F21A85" modified="2019-07-31" version="1">MPRPHSTTTVQMASRVPTSGGSPKSTSPVPPHTFPVPEAKSSTSTSASRTKPKKKSKAASPRRTHLTTNKEIILALKAAVLKPRVALKPVQEHQPSKGAQLPQQPPKPAVRNLSPSAFRRRGILQERSRRWSLYEKLVKCPDLDDAWKTYQELLQDCPSCLKQPIPQKHLHGFASRLVTRSEWVPPSRTRTQTTFLRLLSVLSTVYHTGGQVRLWEWNALIDAAGSGWHKTRVADFNSSFNVYQDMVANRAPGASLSDEPYVPLHDHSRVASQPVAPDIVTYTTLLAIAAATRKEYLLHKAEAELLNSGLPPNRSTLFTYLRYYANRGKLSGVRATLGRMKSNGFVLGLDGVNMCLWAYGRNGRLDIAALIYRILRHHLLAGVGDSPESRADYQDAVKELDELEDLTIPPHLKPDAVTYYTLIQVYAYRGRLRESLVVLEHMMTSPHRVTGKLEDVDMRLSGPVLPNPILPIFRALFLGFARHAILPEHSCRSLSAAEPHEKPHSEVWTLDQLRTLFDNFIDLPQEARPSSRTVYWLLVAFAIASGYDRALLRNVWEKLAERYGTVWDGRIEVFRAKIYEEQFDLRYFEGVRTSRDRYKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYI1</accession>
    <name>A0A4Q9PYI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1038281</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYI1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF0">
        <property type="entry name" value="XAA-ARG DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="176"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="410" mass="44947" checksum="48B5AF5E8F186324" modified="2019-07-31" version="1">MAQSASTVFWQPGDKGAHLDRADVLEEGTIYRPEFFEHVQATLKSLDQDLIGLSKDIHDHPELKFEERHAHDTLTTFVEKHGFHVTRHHWLETAWLAKFTKGNGGRTLVKSAIEHFDISGTVVLLGTPAEEGGAGKVILLERGAYDGMDACLMCHPAPGPRWSTSLSSCLALQRLIVEFSGHTAHAALSPWEGQNALDAAVLAYTNISVLRQQLKPSHRVHGIFEGKDWAPNIIPDYSKMIGDVRAPTRAEVESAVPRVTACYEAAGVATGCKVKLGKTRVISDLRQNKALSDECADIFSKKFGPVDYEYGIKNASTDFGNITYALPSFHPSFTIPTRGSNHTPEFAEAAATEEAHKACINMSITLAANGLRLLTDDAFANKASRYIPRSQVKKTFEEDKVLRDAEAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ27</accession>
    <name>A0A4Q9PZ27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AB-hydrolase YheT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_924360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ27"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008126">
        <property type="term" value="F:acetylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051792">
        <property type="term" value="P:medium-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051793">
        <property type="term" value="P:medium-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000952">
        <property type="entry name" value="AB_hydrolase_4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050960">
        <property type="entry name" value="AB_hydrolase_4_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794">
        <property type="entry name" value="ABHYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10794:SF63">
        <property type="entry name" value="ALPHA_BETA HYDROLASE 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01133">
        <property type="entry name" value="UPF0017"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="134"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="467" mass="51435" checksum="997B916118337043" modified="2019-07-31" version="1">MAFTLLLVVGFVGIVYVIRGIWRRKTGRDGPFVTLHMAQHPAILQKDNESSGPALSLAQLVRDNVPALGPNSKFHGVWWLPGGDAQTAYSSFGDFSKVDPVVYERLFLELPDKGVVAIDVTPPLSSHPIQNAENVLLVTHGLTGGSHEAYVRAVLAKVTPSRQSGGLGFRAVVLNFRGCNGSPVVTPRLYHAGSSDDLRHVVLWISTSFPSCRMYGLGFSLGANILAKYVGEEGEQCPLLGLVTLANPWDFLEGSHHLPSTFLGRHIYRYVLGGALRALLRLHQGVFLKASKLPVSRSVLDDVLRRRSITLRQYDELITAPMYGFANPYDYYSNISSCKVAPDIRIPCLSINSIDDPITGTRSLPISQVSHSPYLVLAVTETGGHLGWFEHTQDGRIGRWYVKPVEQYLAALLDYGLQDRQKPSVISLGTDFVHQEGRDDVGFRVLSREQSELIVSGTEESKLFTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ47</accession>
    <name>A0A4Q9PZ47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-L-rhamnosidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_976199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ47"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZ47"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="132" mass="13554" checksum="130F50C560F3F6B9" modified="2019-07-31" version="1">MAFVQTYVGGIQLVSAAGATWAIVPQVGDLTHVDAGFSTTLGRVSSKWFANGTVFGIDISTPQGTTGTVGVPLPGNYTTATVSSADGGGGFVRADESGRYWITDLAGGDHHHSAAFSPAERHLGFNKPSVNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZX1</accession>
    <name>A0A4Q9PZX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZX1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8236" checksum="AAB547DA040A6FE5" modified="2019-07-31" version="1">MVSICSVSVSGFSAQLAGSLRLCVMIASKPIFRLQYRVRMTRAHTIEICRAARARNADSGTAWNVLYFAPGRETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZY7</accession>
    <name>A0A4Q9PZY7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_947434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZY7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZY7"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
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        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="191"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU60259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="507" mass="55361" checksum="E71BF4D2DD9405E7" modified="2019-07-31" version="1">MAETATFSSSGVDAITRPIHLEEEVPDILSQAQLEESYDIARTVDEIEKGDYKRIALQFSDELLPHSVPIFRALKSRTTEGREFYVLADTSYGSCCVDEVAAQHVDADALVHYGHACMSQTSRLPVIYVLGKKPIDVSHCVESFAEVVPNLSDKHSIVLKYDVAYAYEADLVITALKNKLSSSTRILHTPVTLTSHPASSGQHRTPQELQETGADPSPDSNVSPESSAILYIGGESLTLTNLLLTHASYEVYAYDPKTRTARLESGRTNKLLMRRYVAVQKARDADVIGILVGTLGVANYLPLISHLRTLLARAQKKSYTISVGKLAPAKLANFLEIEAFVLVACPENSVLDAKEFLRPIVTPYELEVALRPTQEWTGRYVLNFEELLREGQAESEGASVSAFLEGPADPDQPVFSLVSGKYRHAKRYGGKDEGTANGDTDSSAVVLRNQGSAVAIMSDSAAAHFLQQRTYQGLETRVGQDAPSLLEQGRSGIARGYDDDHREGSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0X6</accession>
    <name>A0A4Q9Q0X6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress protein DDR48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_975956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0X6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="26299" checksum="152A274F1FF29CFB" modified="2019-07-31" version="1">MSGYGNDNYGSSNDSYGSSDNSYGSSRNDNSAANNAYDSNNDSYGSNNNNNNNNSSTDSYGSANNDSYGSGGNRNDNSYGGNNADSYSSSNDNNNSYGSSKRDATNDNSYGSSNLGSSNNDNYGANNNSNSNDSYGSSNNSNSYGSSNDPNGSNGNSYGSSNNNDSYASSNKSDNYGSSDRGNDKFSSDSYGSNSNTANSNTTNSSSSGTGSGDWVEKGVEYAAQKAGYNLDSDTANSVAGQLRQGLSKFSGGNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1X6</accession>
    <name>A0A4Q9Q1X6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cation/H+ exchanger transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_213478</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1X6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562">
        <property type="entry name" value="NAPA-TYPE SODIUM/HYDROGEN ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43562:SF3">
        <property type="entry name" value="SODIUM ION_PROTON EXCHANGER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="38"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="467"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU61207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="596" mass="63246" checksum="517781EEC5247611" modified="2019-07-31" version="1">MPRAALPYEEPQLVDLLVIASFLYLLNVIRVVADYLLHAGIIAEITFSIIYGFPVANLLPIEWEATFTALGYLGLVLVVFEGGLSTNLPVLLSNLPLSIVCALTGISIPIGFSFALLNAGFGYKPLEAFAAGAALSSTSLGTALAALNSITRNRGATPAEKQPTHIASSIPSSPHQLPLQQTRIGTVLISAAIIDDVIGLVIASLIPALASVDPDSHGTSHGHLAWTVVRPLLSSFLIAVGASVIARFILRPAFWHCGTGERWCAPAREGKAWGACAFAREGSGWGTTAHADAVKLLAMVAVVSGMAAIANCQYIRSHASSSWNLVLYSTDTDTSVLYGAYLAGLILTYICQPPTGQRSSETARELSCDKTFARTVGPLQGHLFLPLFFASIGFAIPFLDLWHPTVIWRGILYSVLMCLAKLAVGLPILVYPVTLSLIRTTAYKLQELTHKTRSGGSRSLQSMATRISRSGRQPMGRTPTLPHTCPKSAIQEDEKIDSLRHGSLLENLDETSLGQAAASIPAATFMGIAMVSRGEIGLLIAQLARGNGSGETPGLLGDEAFLVCIWAILLCTLVGPIGTGVAVRFWGSRLASGLWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q204</accession>
    <name>A0A4Q9Q204_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1037839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q204"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q204"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="741"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1124"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="843"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1132"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1180"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1243" mass="140024" checksum="F178748E105F0015" modified="2019-07-31" version="1">MCALLTAYIQAEREASIPVFVDPAPEGHRQRRIPAKLAEMLPTSLRGLPNFRLKPGVTAPMARRSGLVPHAAPPASLSVASSRPRATVEDAPEDGMEGVEPPTRPPSPPPALPPPIDTPPNRFGVFRQYRATPRSDPESGLSLEAFADAGTHLRAPPAPGERDALRPFGPTVRSWLSGARDVAANSFAPFLNWSTFKLMEWQYSGSITKSGAELQRLVDDVILDDRFNKEDLLGFNVDREQRRLDDFQATSGAFSAKDGWREESVLLHLPKPGLQQEDEEHTPAFLVDKIWVRSFLEVVKAGFRDISARQYHWFPHGLFRTRATPGNPTAKPERLFTDVYNSDAMIREHEEIQKCPRNPDDPPDVEYVVSGIMVYSDSTHLTNFGTASLWPIYAFFANLSKHLRFKPSMFAAHHLAYVPSLPASLLRFYEDTYGAPASAAVIRLLKYDLMTKVWLLLLDAEFMHAFEHGVIVVCGDGVTRRIFPRIFMYLADYPEKCLLACLKTLARCACPDCSMDKCSFWKMGMKKDKADRVKHAREDTGVLQDLIARVRRWIYEDGTTPDSDHIKKTKLGFFSMAPVRSAFSQRFAAFGRNVYQLFVPDLMHEFELGVWKGTFTHLVRILIAAGHDGVQKLDERYSMISTFGRATIRRFSDNVSGMKKMAARDFEQNLKCAIPCFENLLPEPYNSRILDMLFELARWHALAKLQLHSESTIAALDASTSTLGQAMRAFLRHVCRQYSTQELPKETQSRQRRKAMSGQNARSATTVSPKQKAFTVLNTPKYHRLGDYARSISETGTMDNKSTQAFYRRTNKNQAFGGQIAREVRRAEIIHKIQQSQGDGAKPRNKTRKPKRASAARGKRLHVHFEQAEPLPPTQPNRHYHISDEKRFPVRLDDFLYDNEGDPACENFVWELKAHLHRRLPGGETLPPDYMPTVDDIFSVRIENDKLYQHKVFRLNYTTYDMQRDQDSINPRTHPDIMMLAPEGAPHPYLYARVIGIFHVEAYRAGESLDGADDTDMELIHVLWVRWFDLDPRAPGGFKARRLPRLKWAALDDGAFGFVSPDQVLRAAHLMPAFAHGQSDAALPGYSVARHEDDEDTDWKFHYVGIFVDRDMFMRYYGDAVGHQRGDSGKPGPAPVPAPEPITPLVGDGYDDEVDEEPQDATTDSGKPLGNDQEWPLGPDGEEGEAEEPLDDGENEDEEDGPDDDDRVESDDSGDDAALGPEDGEAGMDEDEDELARLGFAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2G8</accession>
    <name>A0A4Q9Q2G8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_239815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2G8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="551" mass="59696" checksum="A1105028BF83AA09" modified="2019-07-31" version="1">MPAYEPASPVPSPPHQPNVLQPVPVGPLAMPSRPAADPHAIFMEWVVLAMIALCLGTMAIVICRQLCAALARRRGDDTHRRSARYCAKTAPRTLILPTLNEKGQSWSTLKVPTARLRTAASSRVRDSVLCKSIGRLGRSDAGKLVQDADMTDNTYSDNVGVYASLPSSPDTDPDSTLRPYLPPIREQSKQEWNGYRSKIRLATASGVSSTTSSPAIPAIVVEPCPDVFRGMPESPTSTSMYSQESWCSSIFASPTDSERSTPGPPPYTPNFGTLALDVAPMKLDTAGASSQGPPAGDDFPRMPGSFEASYLRAPAPNWNAPRQVGECGHRRAEHRYPLRNVSSTSRETFVLQRPRPRKKPVHGSTYAPADRSGGVSRALASDARLLTGSARELALATPRESTYTSTVTGVGLGISTRPYSSAADQDMEDVRLLVLDPRRKSTAHRDSTLRFSTLLDAYRCSVSANTLYASPASLAPPGNRNTLDPRLRMILDQYQGRDPCDDRSSIHRALDGWVNAGTCREGPRSPVADSYCSRGLAYDRSEDHEPGYCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2L5</accession>
    <name>A0A4Q9Q2L5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_236585</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2L5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2L5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22582">
        <property type="entry name" value="BRcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="203"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="586" mass="65816" checksum="45D839DCB916578B" modified="2019-07-31" version="1">MAEVASHANADMLNELLIAKLLEEDMLALKNARAAEELQLHEALSTSALAAGRFPKKAKSSGAGAVGTIDDDFVLTVLAAEINANKDALMAQSLQHAQDSNMVASRQYAQKLAAAEKKSLLDAEFARRLQLQLDEGDDDDDEMNDLDAESVLGQDAIENIMAADMNEKGKGRVAQLKPKEKGSIPDSYGRGLVFRKEEGSTKLNPVCGICMEPFQATYSPSAAARSANSSDRIQFGTHLTCPQSHGYCISCLNNYINSKLDPDGSGLGNTNSIVFPIRCPECPINDWPDGLTDEVAQRVLTEEGMTLWHRQKLLDSIPKYYCPNPKCSELVQTDEDSEDPQAMCPSCDSVICVPCRVIWHDGLTCDEYQDLPLDERSPDDQKALQLMKAQNWRRCPNCAIIVELTLGCNHITCRCKTEFCFRCGAIWDVRKGSCSRRPSCDLWDEDMLLEERERQREREQGRRNRGRAPVVVVAPPAPPPLYEHHIGYAVAEHNDDYVQNLDWMDNPDILCTRHWFTANMINSLTCQYCDAKLNSIADLRYHLSHVRWHSVYACCGRFFKRDVDFERHLDSPHTRLGLHAYIFRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3K3</accession>
    <name>A0A4Q9Q3K3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Concanavalin A-like lectin/glucanase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_175907</name>
        <name evidence="3" type="ORF">BD311DRAFT_651541</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3K3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3K3"/>
    <dbReference type="OMA" id="NAYWEIN"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597648" evidence="1">
        <location>
            <begin position="21"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="35"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="36928" checksum="1C2662083266EF10" modified="2019-07-31" version="1">MRTGYALLPLGSLLIPLARADYFFKTSYTGRDFLEHWTWQTLDDPTHGRVDYVDQATALQRNLSFASDSKFVMRADSINVVPASAPRGRSSVRIQSVEAFSEAVIILDLQHMPEGCATWPAFWSLSQAGPWPKGGEIDIIEGVNLSDENLSSLHTSPSCTMAPRRRMSGIASSLDCDTNVNSNQGCGVQYADPLSYGALFNQYDGGYYVIVRTKYEGVSVWFWNRWDPAVPWEVKLPPTTDLFGPARVFPTALWGVPDAKFEFGSNCDYEEHFDAHNLIFDLTFCGDWAGNTYATSGCPGTSCVDYVNNNPAAFQNAYWEVNAMHIYTRLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q438</accession>
    <name>A0A4Q9Q438_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_920208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q438"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q438"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="407" mass="43604" checksum="38D87EAF4833D337" modified="2019-07-31" version="1">MASSVSLNAASDPLAELPTVLVTTTTTVTSPTATEEARVQDVNGTGSPVADEPPRPQAGPLPRKRGEIGFQEGLHDVPLDEGQASSSTTSLPERHPADREIPPSSSELSPPPDEQPPRSPSRAESTNTANTTGKRSIISFFKPKRIPTYFGLRVTTLAIFLFQLALFGGTIAGWVLTVQWMHKTGSSSSSGSSDSDGSGDSTQTNVFSSTSAQIFIHVAFGIVCLAELIFLERTLFRLRAERYGHVHPGEILPSARTRASQERDMAIAFAPWNRPPLPTYAAALAQSGLGTGDVEDNIIAIPPPPAYGNTRGSTLLLRGFLSDALRAQRPRSNGSVQSSLSVGRSERSRANRSGEGGEDEQDRPKSYVSTDSEWEARLDADRALILEETLSRLEEGTARSSSRAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q479</accession>
    <name>A0A4Q9Q479_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_946556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q479"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q479"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="312"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="684" mass="76814" checksum="4F8A41A2583C2B00" modified="2019-07-31" version="1">MAFSLFRFARFLRSIFVPTASIIAFSCLLTFIFVLYQPTPGPGSLQKLGWQSWDTVNDLTGQVSGSSRPADDLESPSSGSSVPEGVDWWNVTTSSDDLDVASLPLDVWDPLMQHDTGSCGAWLKTYLSVSEIHITECLVDPWLIPSMASEFCTPPSTKEDDAKKGKWVRVERNLKLQVSMKSLNVYYRSTRRHDIPLVTEIRVLPEKETPSPFSHSWIKVAHPLNPFGEKRYLWYKAEKTWRDMTDAERKSDLITEIDVLFGSDQPWYGFERVQQATYDGGGPREPVWLTYRKGVKPPPRAPPLHFSRDGKFKIMQIADLHYSVSVGTCRDTILSPCTESDNLTTTLLSRVLDIEKPDFVVFTGDQLNGQMSSWDERSVLAKFAKAVVDRQIPWAAIFGNHDDEDGMSREAQLRYLQGLPYSLVERGPKDVHGVGNYVLKVKSADPSMTHLLTLYFLDSGAYSSGVQDWWGIFHASDYDYLRQDQIDWFLQESSSIDAIERPFTPDGAKDLGSVWKRQAADQVLPNSKRLAKPNAMMFFHIPMQESGAAADVDPVTGQPLDVGNVLEESGASKKSAGFFHKGLLQAFESDHRAGRRATEVKVVANGHQHNSDNCKRVKGVWLCFGGGGSYSGYGQIGFDRRFRIYDISDYGETIRTYKRTEHDDVLDDMILVGRGAPPPFEGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4M8</accession>
    <name>A0A4Q9Q4M8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919772</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4M8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4M8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12857" checksum="E2D496F18C599BC0" modified="2019-07-31" version="1">MPLQESPDPATPAWAQDVKSEYLIFFSSRGESGKLWCPDCVAVEDLVKQTFESVEGPSGTIVYVGQRSEWKTPSNPFRSQPWNVQSVPTVVRIRDGARLVEQELGEKLESFIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5J3</accession>
    <name>A0A4Q9Q5J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclear protein 96-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_810400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5J3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5J3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear pore complex protein NUP96 C-terminal" evidence="2">
        <location>
            <begin position="349"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="842" mass="94260" checksum="527F728C26084390" modified="2019-07-31" version="1">MDEDELRPATRRQATYDEDIEEDEEDGTEEAEEDVDETEDESEEEVLRRRGRRSAQPTRAQLSRQGDPTIIPWAREIGVDPQKMHVMQTSLFRMPEEERVLKALNEPQPRRKLLQLKSALTRKHSRDSEGEGLRADSRQRASFADDIEPEVYRPSRKYARVESSASAFVGREGAYVDAGLALGRSFRVGWGPGGLLLHLGELCGPSSTPTSSANVSTVKMTTVPLLAGTAADASAQASRLLSHHLHHTVIEEDEDGVPFANPSPKLSFASFVSQFPSTDQSFEPTLFRLGRALFDTSDYRLEQIPDPSARQRISDIRRKTELSNWLKTAVSSATESDLRKDLDARWDRTLFTLLSGYQIERACEKAANDGNVKLASLIAQCPGDAAFRADLQSQLDIWREQRTDAHISEDTRKVYALLAGVVDTLQGSGGSGVEQCPDVDLAKGLDWKRAFGLQLWFGMPMDASIADVFQEYDRLWREGLSSVAAPVPWYAERPFAEQVASKWTAPSNAQPTDALYALIKLFADPACNLSSILSSFSFSASPADYRLPWHLYIILSRCMRIRDLADRDTSVRREEDEEEGAVEGHSPSADLLANSYASQLEQLGMVQEAVFVLLHLEAPAGRVKAIKELLTRSASKLDDWVTRGLVGSLKIPMTWINEARAIYALDSGSMYDAYELYLQAGLYDTAHDIAVVELAPDAVIRQDLILLREMLEPFEGHSVNGWNERGRAFMDYTHAVTRLPQLRERLVKGHLSADEAAELDQLARSVPKLINILPEVLPDRSNIRHNAALTEMTSKLIHHLDRTRPLAVAQSQIRTPFFNDATRVRNIHSTMYEKFLRTVEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8I8</accession>
    <name>A0A4Q9Q8I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_530329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8I8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18514" checksum="1FE64717E8CEE29C" modified="2019-07-31" version="1">MFRPLDSSGLLSGADRVTRSGAYSLHPRVSSPHMLQTSFYRSSRGASPPDTPRSSYVAAHHRKQASFRVELRGHYHHQTCLRPFWAVLRVIRTGLLGILLALLGRVPWQSTACNRDRALSVACAHRGNESADGRGIGEKPTEGRLGLRLPHYSRDFPDPTIWHAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q961</accession>
    <name>A0A4Q9Q961_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_915400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q961"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q961"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="8"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU64122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="392" mass="42275" checksum="D3225832757504A1" modified="2019-07-31" version="1">MSAQRLLVDVHTHVYLPRYAAFLRTRSSVPRIFTRPSPESGKPEERLLILDDEPSSGRPIGAQYWERDEKLKFMDRHAIDVSVVSSANPWLDFLPASTAHTLATELNTDLETYCSAGPSLSDTLKRLYGFGLLPLVPGATTASLISTVEQIAALPHLKGVIMGTRGLGNGLDDAALEPVWAALEAARLVVFLHPHYGVDKHAWGDKENGHVLPLALGFPFETTIATTRLVLAGVFDRYPGLRVLLAHSGGALPQLSSRLASCVAHDPLVAARLQHDARYYLGKLYFDAVAYGAEELGFVSDAIGRADKYASAGASAAASSAKGTDGTAQKRLGAQRMLFGTDHPFFPPLSESEKWKSVVENLEAIDGVYGWDEADKDAVRGGNAIALFNLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAU7</accession>
    <name>A0A4Q9QAU7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_838176</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAU7"/>
    <dbReference type="OMA" id="CASYYMR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033932" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="58096" checksum="B1C9BFFCD00C1420" modified="2019-07-31" version="1">MLLVPSKRAAFVGLFLAISQVLAGQVPVHNGVIGGVPDPSTRLLSTAGVLAATGSGTIVQTTPGKLRVVENSGICETTQGVYQASGYGDLTKNQSLWFWFFAARENPDAAPLTIWLNGGPGSSSMIGLFQENGPCRITNDSTGVTLNPFSWNNVSNMLYLDQPVGTGFSYGNANVSTSPEAAADVWKFLQMFFSDSRFSKYQKNDFALWTESYGGHYGPTIASYILDQNARVANNTVNGTTINLKFLGIGDGLTDPLAQYPGYLTYSASNPYHPLVSDSVLQEATDVWNRTGGCQDLIRQCYSTNTDQVCSQAQEVCNNGILSAALGPYDPYYVLSTEPDPYPPDLTPYLTSTALMEKIGAESTWVMSSDDVYFNFADSGDWMRNSRPLLESVINAGVRTVIYDGDADYILNHVGVEAMVDALQTKFTDEYAKQEFANYTVAGQVTGIYKNAGTFSYVRIYGAGHEVPAYSHGTLGVGQAAFQVFSQIMSNSSLSPTNSSANGTTGSAVGQPSSHPNSSPLVSSSLWVALGSLFLAIAIVPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBK6</accession>
    <name>A0A4Q9QBK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Reactive mitochondrial oxygen species modulator 1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_913086</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBK6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13084" checksum="516011A8088BA1B8" modified="2019-07-31" version="1">MPPAAIPQQQGMTVWQKLKMGAAMGAGVGLTMGFIFGGLSILRGGAGPRGVLPTLSQYMLGSAATFSFFLAIGSVIRNDGELPPHLEAARLQLASPVMRTRSEGLANMRLRWAMENAQKPDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBP6</accession>
    <name>A0A4Q9QBP6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_404560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBP6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBP6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="846"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="194"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="414"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="683"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="981"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="857"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1205" mass="137598" checksum="8CF4B28F0EA11C5F" modified="2019-07-31" version="1">MYIKTLTIQGFKSYRDQTQIEPFSPRHNVVVGRNGSGKSNFFAAIRFVLSDAYTSMSREERQALLHEGVSTTQTLSAFVEIVFDNSDNRFPTGREEVILRRTIGLKKDEYSLDKKSASKADVMNLLESAGFSKSNPYYIVPQGRITALTNAKDHERLALLKEVAGTKVYEQRRTESLRIMAETDSKRAKIGELLEYIDTRLNELEEEKEELKEFQEKDKERRCLEYALYQRELEEVGAALEEIEEERRGELHSANIRREQYTDREKQVQNLERSIAQLRTTVTTLNLTRQGTQSELTDLIRARTELECTIADLQLAAQRAGGRRTVLEDELAAVEVTIAAKEAELTALAPEWGRVRAAESAERRLLDEARARLEALYAKRGRLDKFRTKAERDKYLRAEIASMQQFRRTQAAALSGLEQELTSARQSFEEVNRSIDDTQAKAEDARNQVRELGEQIARLKDEQAEKTERRKELWREDSKLESLVTHAAEELRGAERTLASMMDKDTGNGLRSIDRIVAHMPNFEGVYGPLYRLFEITDDKFNIAVELTAGNSLFHVVVDTDDTASRLVKIMMQEKNGRITFMPLNRLKPKVPPSPNAQDAIPLLDKLRFDPKHAKAFQQVFGKTCVCRDLTIAAAYVKSHGINTITLDGDKVDRKGALTGGYHDVRRSRIDAIRNVTTWRAKHAEHDARLREVKATIAALEQEITRGTGELQKLAARQAQARAVRENVAEEVATLGKEKERHAARVARLEGEIEELRSELSGLDARIEGFQTELRSPMAQNLTGEEEDLIETLGREVEQRQRNLVELGKQKNQVGGSKNILEIELNEGLVRRREELRLKIEGLGASEAGDTDSEDALESKTRERKALNNSIESLQKKIQETEKELEKTSTQLQEQRQKLESIQSQQAEDVRGISKQQKNTERYLAKRQMLLNRKDDCNRNIRDLGVLPEEAFEKYTNEKVDRLMKKLHNVNEGLKKFAHVNKKAFEQYNNFTKQRDQLIQRREDLDKSAESIEELVEVLDQRKDEAIERTFKQVASNFEEVFEKLVPAGRGRLVIQRRIDQDEEDAEEADETQQSTIDNYTGVSIRVSFNSKVDEGLRIQQLSGGQKSLVALATVFAIQKCDPAPFYLFDEIDANLDAQYRTAVAAMIHDLSATAQFITTTFRPEMLNTADKFYGVLFNNQKVSTIRSIRREEAMEFVEQEAQAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBT4</accession>
    <name>A0A4Q9QBT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_944097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBT4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBT4"/>
    <dbReference type="OMA" id="RATTHIA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011465">
        <property type="entry name" value="PRK14886.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="200" mass="22046" checksum="4190A7C60D242339" modified="2019-07-31" version="1">MHTFHYPHLPTELSTVHVALFNNVTNSSEIRSRIVRASQLHGPDGEAEREAVNFAFIDARLICSVLHLQTAVYQAILAQAQDSLRTKTVHSEILWALNPTNNISEAIRRYGVADSTTSLIVVRISSPHLSNVQELMSRVVTGTLSPLEDLSNITDWTTVKKYHKLNTEPALKAVAKDSAQEHIVVNEIVTSTVATKSVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCF5</accession>
    <name>A0A4Q9QCF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_2385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCF5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18645" checksum="798B4D7817337AEB" modified="2019-07-31" version="1">MGRTWGRAHCQARRGRRTRRLPRQRLVVVVVKCRVVAVSSSKPGLPRRLSALPLRIPSSSLLAALTPTSLTGHLDLVCPRLSLYVLDYSANKLHGIHTAHLLDDAGLLSTRQPGTRGPSKHSSPGYIATQHLLNKTNDPSQQAFNLGRNSIVGDPYLQAKSTSLMHEYVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCI1</accession>
    <name>A0A4Q9QCI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_913394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCI1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCI1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="376" mass="42662" checksum="C1D9EC40D18F5860" modified="2019-07-31" version="1">MSFSLLLPHSTLRSPFNALPLSHWAHWSLTKCLYHALAPRTARMASDAFVHDAPNSRPSTSGQHMVTPTSGVKRSFTHLDEGKYEDPSLMSLPSNDTDAWYYPSYGFEANDEDLPRPAFRGNWGIKSYNEAKWVRKGKMTAWGPWMEDWESEDRARKRIRQLLPTDEEQDAPLTLPHLRSPSPPLMAPYPHPNTQHLSYTSFVLDKATTHSFRSSVFNELEDSTNTLIEGETTLRRALGRLWQVMSENPDEVGVSTSLVPKREDEEAEGNDADNRLARAPDLTPVVHKLFLSPNQESIFDNTQFSRAEMQLETLEKSLSNLRELQDDGREYVERLEEIREGLGDARTQRDGVWELVRKKAIQELQEVASSAGAGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCN7</accession>
    <name>A0A4Q9QCN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Indoleamine 2,3-dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_943085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCN7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCN7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033754">
        <property type="term" value="F:indoleamine 2,3-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF5">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="411"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="binding site" description="proximal binding residue" evidence="4">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600898-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="442" mass="49797" checksum="A9ED2DBB2298B1E9" modified="2019-07-31" version="1">MDLNTLRTSLTESAVPQTFNGDAYDVDPETGFFPRRPLRELEGDFALWERTLVQARSVLKLAADRGEEAIAKAAQAEQWRHRVRNWPLLDVKTLGSNIWTLRRAHYVLTCILHFYVHSLPTIQTQGQTIIPRPLAVPLCEVSKRISLPPVLTFADTVLWNWEFKNPDKPLSLDNMRYINVFSGNETEENFYLLSAAAELKGVEMLQIIERVVNMACHLDRNAVASIIRDFEQLVRVIDDLAATLKEAPKTVHPHTFYWVVRPWWNGSGDASPWVFEGVPPNSTPHLSGASAGQSSVMYALDAFLDVDHALKHARQPAPSEDNKRTASSNFMAKMRLYMPAEHREYLAEVQKRQVRDVCQRTPALRAPYNAAVDALKKFRDTHIITGTLFIVSQARSQPPEWMGAPDVAVTREGRSKGTGGNPVSALLKAGRDATKRTMLHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD56</accession>
    <name>A0A4Q9QD56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha-ketoglutarate-dependent dioxygenase AlkB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD56"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032870">
        <property type="entry name" value="ALKBH7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052:SF0">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21052">
        <property type="entry name" value="SPERMATOGENESIS ASSOCIATED 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-ketoglutarate-dependent dioxygenase AlkB-like" evidence="1">
        <location>
            <begin position="39"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="249" mass="28834" checksum="15357B03506D0D3C" modified="2019-07-31" version="1">MLRLFPVCRSTLRLQRVTGASYVSHRGFGTQATRLPPDFTLFPNFFTVDEQCLLLKASLKKLDTMESGKFRRRRRQFLQSYNPQPSVNPVQALFLPDDFYDFQEGHFDGVIRRYREMHVTAWPEDMPEIIPLIERLRELHPNGEIQTHILHLASDGTILPHVDNVEASGTWIMGVSLGDERILRLERSDLPEERYEIPLSSGSVYIQKDVVRYDYRHSILQSGDGTHPPSEGKQRLSIMIRDRFISPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE82</accession>
    <name>A0A4Q9QE82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_803609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE82"/>
    <dbReference type="OMA" id="PHFLANV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU66025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24739" checksum="13DDAE01964A5F8C" modified="2019-07-31" version="1">MGSASSKPAARKLARTPPAWVGARTPNPNVGEQLHPHARPLPRASETKDEGIQRDAHDPQFLANLSKLGPVRVDHHMQTIRPAAASAQRIHDTRLRSEEEARSPRSTRNRLVAESLLELLEERKYVATQKDLEALAKKFDMDLDKLERLARHVNSVSVNQETVKRWVGEDGSGMGQPKNKDRATNAGFQPLTFWFDPDHLQNDDTTPHSHKFPSGTRISTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QF10</accession>
    <name>A0A4Q9QF10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Vacuolar import and degradation protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_912228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GID4/VID24 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QF10"/>
    <dbReference type="STRING" id="114155.A0A4Q9QF10"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045721">
        <property type="term" value="P:negative regulation of gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018618">
        <property type="entry name" value="GID4/10-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534:SF3">
        <property type="entry name" value="GID COMPLEX SUBUNIT 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14534">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09783">
        <property type="entry name" value="Vac_ImportDeg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="92"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="404"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00061469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="478" mass="52083" checksum="15FCA0DA5BFE2051" modified="2019-07-31" version="1">MPAEHAATSLHDPSQPDPQQSQVKLCLACRCPLTVEAASTPFSLHGHDTNDAVTSEASPVCASCRIPLAPPAREGLFAEVERELLRRAASLQPAGNEAQQQVHELAPPAVSPSPPTTEPCPSPQDIVMEVPAAAPRASTAAALATEPSTSSSGPATGIPRSPRPPSFTLNSPILTRPTLAPIDTSNPPSSSQTPSVRRAELASASQSGYRQRSHASSSSSLDPLLDITRLRVRSQGHHCLYPGATFQGTQKSGRNSYDVNVTIVDVDFSSSHLCGYLRIRGLTDDWPELTTYFDAEIIGSRYGFLTRNWGANEQEDMVHWARFPAFRHVKNELKKPHLTMQDALNRGAVFMRWKEKFLVPDHRVQDINGASFAGFYYVCVDFNPQQSGAVQLPSPVEENVEMATSPTTTHATKPETPSRSRRISVTRGARRAGRSASRGIPSNVATMSGFYFHQNSEPYQQLSLVHVPEHTSSCFEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K686</accession>
    <name>A0A4V2K686_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_910708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145334">
        <property type="protein sequence ID" value="TBU51363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K686"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="319" mass="33747" checksum="FFD168C210F15041" modified="2019-07-31" version="1">MPLGGPGADGHGRSARPTNELSPGLSPTRPGPSPSPPLGPGFGGLTPLPASSPPPQGHLQARIRDPNYPEPYPLMLQSLIMPHPGAPKPATETAGPMYGRPQPAQELPSHDDTWVCLLSSFIMSRMGRAAYATDCVRASLTWRGPWVQSQYWSMDYDISAHTTARTESTDVERSGAYAWACIKGLGLGPTIGQPIKRANFTPTVHTSRPRSRSFSRLTGGDLTISVEALGEGSITNLAMPAAIAHTAFADHDETVEVRHGYNGDIMNVPAPQRATVSISPTVNNTVVTAGPPAVVAPPLGCLNLTMHGETPMDKACSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6A5</accession>
    <name>A0A4V2K6A5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145311">
        <property type="protein sequence ID" value="TBU51533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6A5"/>
    <dbReference type="STRING" id="114155.A0A4V2K6A5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24418" checksum="BBE5E0B540385D64" modified="2019-07-31" version="1">MLSAGQPFIYATNAGYVRGRLRTTLNKALQQVTGDRRAKMRYTPEAFRKHVFLCYNVKLAGWPENIPFRNLSSRDAPSIPDLWRLIHLAESGVLYFTAVTREEVDAAQLSVANAVPGPLFPAPLPKVPRRDVGSRKPRFDGGGNFVAPRHERNGPKSAAWIGEEVADSETVGPAGLRPITMWKDGICCIQDDGSGVWREVTGDLSGMEDPEDPIRDWDCAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K749</accession>
    <name>A0A4V2K749_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K749"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="462" mass="51830" checksum="37949576B025870F" modified="2019-07-31" version="1">MAKIVKRLSSWASLGTIIRDRRDDAAVRTAAAFRSEKFVRRCGSEDEVGLTTPSECGWTAQSSEDYPCSPSSWTVHEKAAIQTSLVFPSTTRTNWIARLSPELWAQVLAYLDDHRDLFRVARVSRALRAVARDVLTRHTFRVETTQVAVAFSEALARTPDLAHTIHHLHICCADSRIPPSLPLAFRKLHELRSLSLHVTDPDLALACVQRGLFNEPLPHLTTFSTSLPCTIELLDFVQTHGTIEDLTVTDDAIDPAVLGPKLPLPSLRILTCRMEFLQCFSRSTTLTHLYVTTDVAGSLDELARLLGSQLVSLQLGLGETPAGGEAWSPAEVTKRFPRLRYLQLRMPEPDQLSFWRYPIDWTLPRHRSPSCTSRSSSPRAVGATGLVLAFVFDCRAPTEYDLPAKFHQTIAGLLRTWAPHVARVLYGQNGRPDTSCVVRAGRHGEEYVRERREFGEDFWKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7F0</accession>
    <name>A0A4V2K7F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_883517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7F0"/>
    <dbReference type="STRING" id="114155.A0A4V2K7F0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="287" mass="31935" checksum="F3581C71241CEC89" modified="2019-07-31" version="1">MSPTKWTSRFRRIIRARPAVSGRVDQDNTTITPDIAPIPSRVPLEKDTVITSAHVRAVRGVLCALGLPMELVLITMILADYYATVRSRRTGYIRIDAHDAGVDVHAARLYLIATLPQESSGGELMKVVNVTWLVKGHDQGWGGEAPGMYSPAYSWYEACIFRRVHSAEEKSQKDINLERLYRVYRDAQMMERKVLAPAGWSLVRNGDSCVWRLQSNRIAKGEFERHTFVWTADGVSEGAEDHGAGAGEGFVKSLRAGDKVGILMRASYPGWSNSVNEAGIEIAYEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7I8</accession>
    <name>A0A4V2K7I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_824699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU55978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7I8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9880" checksum="5DC2CD1548474AA0" modified="2019-07-31" version="1" fragment="single">LSEDPTISVLIEQGPVAGTWTSRVPLLSANPYTKETMAARCIIGTLGDYNQWRALGNDGWGYEDLESYFVRSEKTSGHMFSKYRGSDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8S8</accession>
    <name>A0A4V2K8S8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_998460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8S8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF132">
        <property type="entry name" value="POLYAMINE TRANSPORTER 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="70"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="503" mass="55264" checksum="3CB85116F70D5BAB" modified="2019-07-31" version="1">MEYLGDDGKLTFRKTEESVLDADTEPNPTGSILYHSEGSGANNSAESNVFLVGFDKCDDIDPRKWSKWYLHYVTCVAVTLTSYAMISSTIPTAFAQEMATELKLNSWSVDLAISHYEICFCVGPLMWGPLSDKFGRRRVLLLCVNGLALLHMGCALSQNAAVATFVRILAGLFASGLLPVSGAIVADIWDLQAEEQRLAAFVFPFATPQGGPSLGAMMAMSGIGWRGIFWVSAIFGGVFAALIAATLPETHRPTILVRHASMLRLDTRDDRYRAPLELAPESKVRILAMLTHEPVLILLSLYFASMVACLNIFFEALVIATATFTPITARALTSPTVLMGALIGTILYELVLRPRFYLRRIRRYSRERVPPEQRLAMSIGATPFVAMGVFWFGWTLFPGISICAPLFAVLFVGISSYWLVFVIFAYTIDVYANITATALGCCIAASSIFPAVLPVISSHIFRVLGLHWASTLSGCLMIATIPFPLVLMRYGSTLRAKSRYARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9F5</accession>
    <name>A0A4V2K9F5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Armadillo-type protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_840860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9F5"/>
    <dbReference type="STRING" id="114155.A0A4V2K9F5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="817"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="879"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="905"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1167" mass="125562" checksum="62C3247B6D7DECF3" modified="2019-07-31" version="1">MENVLATQSAFQRLKGFCVPLLGNSLLTPSSTPVINKLLSQLHHALLHLQSERHVFAPATISYVFFPLSSILRRNDVSTIPDQTLEKILAILALLSDVWWWDMEVTAWEQIFMLCSAILGGIDRKGKGKDRDDETKLAAARTLWALLRERIPSEDPAHHGDRARTNLAAFIAHAQTAKFLPVMGQTLNSLLTTAESQHLPLQRMSLIVLSAIVKDYLPDGFVPSILPGTVSSMAKVALGTGSSRGWANGDIVAAALLVMEQVIVRAIGNDICIREGAIRNVDHLEDLVGDLRSADINVDAPPSSPYTTLRTATWLRATSSQLHIAINSLSPLVKHQTPAALIGLATFSAAVLSATAITLPQSQPLLLSFLLSLRGSPFERVSRQADTALRQLLTAPSSSRHLTLKVLLQISSDNLAALPRLLLSHADAKVEHAADILHSVCLLATAPAGSQLPAVPAISAGVGKLLGPHGGVEKWGWGLLSTLEFANPPLVVAQGQQASAAQLALEGAAHAPTPFPELALRHVSSRSAQEALARTFRALGATAREECLFAAEWFVDVGLGSRGQRAVAALWCACRLLEGAGGVELGALASMDMTASVAARRGKRLEKFARELARRIAESWDDWDDDEAPDQAAGPQGEADPGEENTLVEHVQGLVTVRGVPGAEGVASAAARAHPGVQPLLHRALSLQLLAVAAGILEARFLPLLLHVLYPVLHAVVSETSLVAASGLAALEFIASSTSYATPANLLLSNFDYALDAVSRRLTRRWLDVDATRVLAVLVRLVGRDVVRKAGDVVEECFDRLDEYHGYEAVVDGLVEVLGEVVRAVEEDEENRLPRESRSAAFCGPGRIEDARRVDDFVAWFAQRRDDTDDTENAGFSGPHRDKSYPREPWAKKAGEEGSEEEGATDGSAPPTTPPTAATQPGSRAEDDPSAEAPPTPAQALTTQIVARSVYLLTHGAPTVRARILLLLARSVPVLPEAALLPAVHGAWPFVLNRLADAETFVVSAAAAFVAALAEHVGDFMARRVWDDVWPRFRAMLQRLAQGDRASALARRAPGVGEGVGTASAYTHSHRLYRAIIVTMTAAARGVQAQDAAVWEVVVLFRRFLRRQAHEELQACARRLYVALAENNEDAVWLALSATLGRVGGPVAFLREPQWDIEQNVKIILSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9K7</accession>
    <name>A0A4V2K9K7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_389321</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="14">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9K7"/>
    <dbReference type="STRING" id="114155.A0A4V2K9K7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="14" id="KW-0106">Calcium</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 14" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0843">Virulence</keyword>
    <keyword evidence="12" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="16">
        <location>
            <begin position="55"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="14">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="369"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU64248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="410" mass="42119" checksum="DAD6F266AAF085B5" modified="2019-07-31" version="1">MQSRETSTHGISKRARGNRKSRTTLNSIPAMTSTATSKPAQATGPVSPDDSCKTKITPACLQAIYNIPPDSALNTSSNIFVASFVGESADPADLKKFLGEFRPDVSQGTTFRVKAVDGGTNNASKATIEASLDVQYTVGVAAGVDTTFVSVGSNNTDGIAGFLDVINDLISQEEPPFVLTTSFGFNEKDVPVGLANNLCNAYAKLGARGTTIIFGSGDGGVAGIQNQNCTTFVPTFPSSCPFVTSVGGTNSFGPEVAVSFSAGGFSNVFARPKYQDDVVPAYLKTLGSTNKGLFNASGRGFPDIAAQAKSFQVVRGGQTISVSGTSAAGPTVAGVVALLNDAVFQDGGQPLGFLNPLLYSSAASALNDITQGNNPGCGTDGFPTSEGWDPVTGLGTPDFAKLLDVVKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9S0</accession>
    <name>A0A4V2K9S0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_866464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the non-repetitive/WGA-negative nucleoporin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V2K9S0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044611">
        <property type="term" value="C:nuclear pore inner ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.440:FF:000001">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1880">
        <property type="entry name" value="Nucleoporin, helical C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.440">
        <property type="entry name" value="Nucleoporin, helical domain, central subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.450">
        <property type="entry name" value="Nucleoporin, helical domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004870">
        <property type="entry name" value="Nucleoporin_Nup155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042533">
        <property type="entry name" value="Nucleoporin_Nup155_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042537">
        <property type="entry name" value="Nucleoporin_Nup155_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042538">
        <property type="entry name" value="Nucleoporin_Nup155_C_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10350:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="6">
        <location>
            <begin position="92"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="5">
        <location>
            <begin position="681"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1363" mass="152033" checksum="986AF8509C3A2D94" modified="2019-07-31" version="1">MAFRSTYAVPQNFASTSTSGPLIASVNGSKFRQAQVASKPAPVLDLPALQAASRVLQEQLVKDSQTIPDLGDMISGQPSSALYTVFPDDYRTPFQKRRHIGIPEGLWQYYTSTHLATHMGLLPEIERVWISIDHNLFLWDYVDGQELSSYVDQPDVITHVALVNPKSGVFIDEITSLLVICTPVTVLLIGVSTHPVPGPNNQTRKDIKLYATDMSIACDVEMTSVIGTPDGRIFMCGQQDGNLYELHYQEKEGWFGKRVQLINHSVGGMQSLLPRLGSSSSEDRIITLVSDPARNCFYSLTANNTISVWKTNGDKHVQHLQTISNLYKAAQDKVPGSPALTPQNFNIIALHVVDPSESRTGVQLVAVTINGVRLYFSPSSYGNYGWGSTSATGVRPLSLVHVRLPPPNLIHPDEQGRQFRETHVGYGVGQAQPAPPRPFILSNLNNSCYDHGITIAVQNADIADTDYVLCLTPDLTQIGSLGQTHPPQLQQSSAQYANPTYGAVTGPSRPPLTERATLVPIPGLTWGLAPVPRSKYSLATTAPPNTPAPLVTNELATQFSEPARQYIILTNGGLHWIAKRRAVDALRDVLEEFSGESNPQPLIQFRDSYGRDQTCAMLLAIASGNTFLDPMEQSPLGSMSRVSPELVTAAKQAFYDFGERPTWAERVTYGTSEGSGTATFSGRREGLALYFARLVRPFWKVSITKARSGGLQDLNVPDDVLVTAQKNLFALKELLDTNPHLFHSAPGDHTGARSATASEQEAWKAEQSSVAQLLSLLGRSIEAIAFILLLNDHRLGELIAHCEPDIQKLVSSLTFEELITSDKGVAASRALVNVIINQQIGQQISVDTISEVLQQRCGSFCSTDDVMLYKARENVRKAVETRNPVERQTWLGESLRLFMKGARNLEFDKLREIIGDYQQLSYAKGTVELPLYCAQVFDTDLQGQEYWIAGYPQNDSRAQFWERRKHCYELVLDSLSVFEERCVPGKQDAAQVDDPETVRGHAYELAFASEDEMFHSTLYDWLIGRGMADQLLEMRPAYLEAHLRREPVTVEKFQLLWQFYVKDGQPLRAAEVLAVLAESTEFNLSLETRLEYLTLAVSNAKSHPVSVGGRHETAIAFLTELEEKLEVAQVQLELYNTLLPRQNDPELAERFKALSYRLYNITELYQLYADPLDLPLIKLLILHVSEHRDESIVRPIWNKIFEEAVEGVEAKVAADRIMGRVIPLGQRYYPSESAFPLQHIASLLVRFALAHKGELPYGWAPRILTQCGVPYPEVWDILHEMYESQVPPFNEQANVQAISSDIAVLLTDWVEEAKRPQSSASRGEFPVFRIDQAVEQYLAELEPSRIETKAAYESVKRQLRRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWB3</accession>
    <name>A0A4V6MWB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_847074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWB3"/>
    <dbReference type="STRING" id="114155.A0A4V6MWB3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="24"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="434"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="666" mass="75328" checksum="865415C61D3B3C4D" modified="2019-07-31" version="1">MRVLPGIFNVATRFLGRAIRRDCLDRLPNDLLVDVLFDYLDVKDIIRMRRVSRLYYELTHHAAVWKRLLRRIDVPLPPAPLTPKRPLSKISGLEAERLVVRAYSLDMNWRRHHPRALREWSFDAQRRVLAMTLLPGGDYLVASVSNRAGDRYYLVVYAMNAPGAPQALTAVETTTKAYDLQAKYMTIKEQRSIVIAYLRRDYRNKKDRMRAMRGYLPDVSSYSTQYSVADVQFKYECSVLQLSLHTLETLASIPYPSNSREYRYVAEALPKPFNNLFMLTSKSQLSSPVLAEMYGSAYLALVRADNDIIFKRLEGGGAATLTCLELPVAAERSHHIRAIQLLPQESAVFVVREIGGAPGVPHSCPAYAVETYRALECGDAPVTQLHAAEQCIIAWDLGHLTHLHLPEFPSFTRPEDLIAEDKRPAPVPPPHPALRPATPRTSSSARSPSTKVPRPPPPICMIGRAHPQCGRDESIVRMLFLAQRFEVDLPPAPPYYDRHGNPIHRTQIVYRTALERNQTWTRRATDYNAYLRIIPALTRPLVYAIPWDDTTDAPKVLDVRPVIDRGWQRPPRLEDGVVRHPEGLVGCPSFDGGPQELGANVTAFAWDETIGRLLVAEESSNEIMVFDFAAEPVQHFDKTRYPIPLQDIPNPDIAMGPHENPWTVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MI50</accession>
    <name>A0A4Q9MI50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Zn-dependent exopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_931234</name>
        <name evidence="9" type="ORF">BD311DRAFT_761283</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143437">
        <property type="protein sequence ID" value="TBU27065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MI50"/>
    <dbReference type="STRING" id="114155.A0A4Q9MI50"/>
    <dbReference type="OMA" id="HATVCVD"/>
    <dbReference type="OrthoDB" id="7832001at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051458">
        <property type="entry name" value="Cyt/Met_Dipeptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017149">
        <property type="entry name" value="GSH_degradosome_Dug2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270">
        <property type="entry name" value="BETA-ALA-HIS DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43270:SF8">
        <property type="entry name" value="DI- AND TRIPEPTIDASE DUG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037237">
        <property type="entry name" value="Peptidase_WD_repeats_DUG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="31"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="73"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="335"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="431"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="656"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU27065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="907" mass="99153" checksum="F236D6E598018A66" modified="2019-07-31" version="1">MAVSVPLSPVIPDPSLSRSPSVVQHNPTLLHTLHQEHSSVLSLAADDRNIYTGSQDGQICVWDKHTFKLRAVLSGHTGSILALEYAPEKRWLFSASGDSTIRVWNTRSLNPLHILHPHLETDSGDLFSLAWCPHSQTLYFGCQNTSLQWFVFPVTTPELLSSPPSLLSKAYSSSGISTPPSRKAHKFFDSYPRYTRRPADLNARNPTCASCVPATSTTPPSGSSTGSLTPPDPCIHPDGFHPPVAIFQVPPENVIDSAHYGYVYCMALLPSYRDGSDDPPFESGRGRQLQLVTGSGDSTVKLWRLPENQSSNDAPRLIHTFDCGVGAVLALVVRGDTVFAGCQDGLVKVWDLETRTLVRTLLVVENVDILSMSMLHSDLYVCSANGDIQRWSSAFVLTGSWKGHEGIVLSSIITPKLHTEDPVEHATTYALVTGANDNMIKVWEVFPPAAPTSSIDNIDGFGDHADVSRSIDDLLVHALTKFVSIPSVSSSQVHKEDCRQAAIWLRKCLTQLGAEASLLPTGDATNPLVMATFRGTQTSTPKPRVLFYGHYDVISAQPSGWTSDPFTLTGRNGYLYGRGATDNKGPVMAVACAAAELLARRALGADLVLLVEGEEEAGSGGFVETVKRHKETIGPIDSILVSNSTWIAEDTPCITYGLRGVVHCNVEISNEGPDLHSGVDGGAAREPMLDMVKLLGTLTDESNRIVIPNFYDNVRPLTEEERQSYKVLSSVTQTPATLLVARWREPSLTVHNVEVSGPRNSTVIPSSVKAHVSLRIVPDQALEAIASSVREHLEATFKRMRSPNHLKVSIEHTADWWLGNLDDPWFHALEDAVRDEWQVEPLRIREGGSIPSVPYLEKEFSCHALHLPLGQSTDQAHLPDERISLSNLQRGKRVVERFLSNVAGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MIC2</accession>
    <name>A0A4Q9MIC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS monosaccharide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_827428</name>
        <name evidence="12" type="ORF">BD311DRAFT_385852</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143434">
        <property type="protein sequence ID" value="TBU27260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MIC2"/>
    <dbReference type="OMA" id="EGTTIPW"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="420"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="26"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU27260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU54690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="528" mass="57333" checksum="A22119B79A1E4D61" modified="2019-07-31" version="1">MPGGPVAAGGGINASGSKNKLAGIAMTAFAAFGGILFGYDTGTIAGIKQMPDWLRKFGVHTTDTTTYPLGYYLPSSRESLVVSILSAGTFFGALLGAPVADILGRRIGIMVSCLVFSLGVALQTGSNNLATFVVGRVFAGGGVGLVSTLIPMYQSECSPKWIRGAVVAGYQWAITIGLLLASVINNATKNRPNHSAWQIPISIQFIWAFILTLGMFYLPESPRWLIKKGRDEAAARALSRLTSLPPDDPEVETELNDIRAALAEEQKLGDSTYIDCFRFSDNKIFLRTMSGILIQAWQQLTGINFIFYYGTTFFQNSGIKNPFLISVATNIVNCFMTLPGMWGIERFGRRSLLLYGAVVMCICEFIVAIVGVTISVENQSGQQALIALVCIYIAAFASTWGPIAWVICGEIFPLNIRAKAMSLSAASNWLWNFGIGYATPYLVNSGPGNADLGVKVFFIWGSTCAGCVIFTYFCIPETKGLSLEQVDLLYQNSTPITSVRYREEIIAQDVHVSDIKQEAEHHDEVEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MLK7</accession>
    <name>A0A4Q9MLK7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BIR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_817534</name>
        <name evidence="4" type="ORF">BD311DRAFT_324884</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143421">
        <property type="protein sequence ID" value="TBU28514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MLK7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MLK7"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="210"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="273"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="594"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="742"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="776"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU28514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="870" mass="93786" checksum="4B1298BAD3F9744A" modified="2019-07-31" version="1">MEYFQNRVDSFGPLRSKRTKASSSKQPTWPHPASFKATPETLAEAGFYFHPDSDFPDNVACFMCKKNLDGWEPDDDPFTIHYNKCRDSCAWAVVRCQRALDDEGFDFSDPTRHPTSKAMEKARLDTFSKARWPHDAVKGHGANSRAMAKAGFLCNSVEPGDDTALCLYCNLSLNGWDEDDDPYEEHVKRDKKNKTSCAFIKAYTGNALSKSTAKRPASKAASKPPTRSVSRSSKAAAAAGKEAPEEVTDSDDELAAGSSELTVLTKTSDSRASRASSARASSAAKTPGSRRSTRGTSTTGKTPGSRTVSSELEETDGGSESDAGRRTTKSRRKTGRQTKARVSAIVEEEDEMEPPKSTRGTEDVEMAEAEPEPEPQPEKKKRGRPPKSAAANSTPKTNPKNEVEDEETGQELGAEPVHVPPAKKTHARTRSKANLEPDTDTVAPATLKGTHTRTKSTSKVKVKQEEGEDEASGVPAPAPKKKGKQRAPQLVEHEDEDPPSALPAKPKSKAVSRSKTKLKPKPEASDEDVASARDDGSHTRVNSGRSAAPRESQAASERKSSLSEDAGYATAEAPAEADQMEVDEEPAPPKPTKKAQVPAANAVQPVPRANSRPTPASSEVSKRPSPVINGVRSSSGAPPSSRASSSRPPSKLSIARAPTKDTLTVVEIDSDGEGSPERPPKPQSKAKAPASRQESTASVNGVKKPASQTSKKKLQVEVVVPPKTFKPVSSDDAQVQKDALASPPPRPPRSPARPTKSEFPAPGTPASADYHSTHTSPERDTEGDGDVHMSSEADAAPAVSSSPRTYHPFLAQFPIEKLVGLTEEETEMTLEQYIRREMELQYAQLKADGERRIEEFKQKAAETRRLIETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MM70</accession>
    <name>A0A4Q9MM70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951064</name>
        <name evidence="1" type="ORF">BD311DRAFT_663878</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143424">
        <property type="protein sequence ID" value="TBU28167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU54998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MM70"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7214" checksum="1D01E77A51790862" modified="2019-07-31" version="1">MVTSDESPAEAELYQQEREIRTVVNSLWLNTFNGASGLSLSPPTTTAFAPSFCAYLAFLTEGQTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MYD6</accession>
    <name>A0A4Q9MYD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_841845</name>
        <name evidence="2" type="ORF">BD311DRAFT_862101</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MYD6"/>
    <dbReference type="OrthoDB" id="3232876at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="427" mass="46849" checksum="59C11278B47C874F" modified="2019-07-31" version="1">MCAATQRPDFQGHALEPLKNACSSDSEPSTSNIHNDSGDETRTPTPPPMPFSQHPQAIFDDGTQDAAALLTTTHGIKIRDFAYDNTLPPVTTVPRFSVQVQPRPRILQRARDMIASTGRDDGEESDEEDPSFQRTFYIDSSGTGTSHTSRYRKKGTLARTLTEPADEQPLPSQGFNTRPFIFPQPSYAMRQPSPPRPRPGGAQFPTTPNKSGRRSPQGELSPINTFPQSQPSIQGESQESEPYIDTPLVTPNGSLQWPVQDTSALPSSHLESVLPQLADPDVTMSQLGFTPERSQRPRVSPVASPPRRQLRNPHLPPPAEFRTRTPTPAKSRPSSGSPDAPVTRSRAACPAPLQDAPAPRYYLRQRPQDGRSAAPATSRGTSRTRTSGHVAQQAQKPPSKKRKLTPPEPATKPTRGRRRNGDIKENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N866</accession>
    <name>A0A4Q9N866_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1022119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N866"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15912" checksum="3166011164A5D309" modified="2019-07-31" version="1" fragment="single">DRAGVIVTKSIDYYENWRPLCEFFWRISQLPDDKLGFDPTAARLSESDPEWAKMNALAIPLESDANSQPRPLNDGELESESEEEPTYVFDYVRQIFARSLSDSQWPRYKLQMHCGGGVRDFLVGKPTFCANGAIGRGTRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB32</accession>
    <name>A0A4Q9NB32_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_367122</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="ML145346">
        <property type="protein sequence ID" value="TBU51282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB32"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033907" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU51282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="607" mass="65740" checksum="A543950116D540D9" modified="2019-07-31" version="1">MKFSYRFVQSIYLAVVSASIAAAAPAFEGALKHATTQVRGVPGSDLIVESYHPPSLFETFGVNGGDHSLSDRAEFNLKDAAVSFVQSRLGVDAGTIAHRTSYANDVAQHAYLQQQINNIPIANAIANIAFNKANKVVSFGSSFVKPSTVPSTTPSISADDAIAKAEKALFGTYNNHTTSLQFVAQKDGSLALAHVIQIQNNAKAQLYEAFIDAHSGELVQLTDFGADASYRVLPITKQNVTQGFQVLTDPQDRLASPFGWHSDGVNTTNNTSGNNANTWVGVSGNVTYQSAPHLTFNYVQDPSQQPQTYEPNVDAARVNAFYLVNTVHDITYRYGFTEDAFNFQYSNFGKGGAGGDQVYVSVQDSTGTNNARFVTPPEGQSPTMYMYLFTLTDPWRDGSLQNDIVVHENTHGLTNRMTGGGTAACLQTTESQGLGEGWSDAFAEWTEQTNDVVLDWVTGPYVLNNTAGVRHYPYSTNATTNPFRYGDLQTLTEVHDIGEVWANMLHNVYAGLVADHGFSPNAHTDPTTTGGNTVYLHLFIDALALQPCNPTFVQARDAWIQADANRYHGSNFCTLWAEFASRGLGVNAANYTDDTTVPAGCNATVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBJ9</accession>
    <name>A0A4Q9NBJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">QLQ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_835405</name>
        <name evidence="6" type="ORF">BD310DRAFT_982811</name>
        <name evidence="4" type="ORF">BD311DRAFT_812593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143691">
        <property type="protein sequence ID" value="TBU21167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145411">
        <property type="protein sequence ID" value="TBU51074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145362">
        <property type="protein sequence ID" value="TBU51212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBJ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NBJ9"/>
    <dbReference type="OrthoDB" id="2796843at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="QLQ" evidence="3">
        <location>
            <begin position="35"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU21167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU51074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU51212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16870" checksum="8C4FF07570D41F30" modified="2019-07-31" version="1">MVPIGNGVSATNGNTLTAGRVTNQPYPQTPQTPVSFTPDQINAINAQTHAFISRGMSVPEPIQQAIRVPNQATPTCNPSSTTIKREEIEAVDPEKLPKGALLEEDRDPELISAIWAMKMRRLLVPSFMPDGVDPHQTPEERNAYIDARIEQRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBL0</accession>
    <name>A0A4Q9NBL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_972673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBL0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="328" mass="34852" checksum="199C30C92AF9401B" modified="2019-07-31" version="1">MAYNVSYGSQGFCDPTLLATMPLVQEPPTSNGLGLGLYSSCFQVEAAYPWHIPTPPIAPSTPINVPHGMFKFSQYASDAYTVPAYGSNAPHVPAGQGSASTSSASSVPWTPSNAAAPVFTPGATQQTGHYASSTPNTAHAHAPHLYQHHLPSGPPGHPSRSPPPPTSTPTFTPTSTPTSTSTPTLSPDPTRQRAVYLGYVSSAQHERCPMPGCPAALSGSAGAWRAHFRTHHHRDFCRVPACRGGTRCRTKARCPFPDACQDAPGTIDSLGRHLLAVHVGAVHRCPTCGLEKVWRSDSCKRHVERCGRKGVEEAEKEKGPRRAKNAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCR2</accession>
    <name>A0A4Q9NCR2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1043408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145288">
        <property type="protein sequence ID" value="TBU51759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCR2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="610" mass="68336" checksum="8C6E1E0B76A8A8B2" modified="2019-07-31" version="1">MISRHSDSTLPFPEFASSVPAADRAVLAGLSRDDIRALTLRKSKEYRLLSYAMLSIHNAAAPINTLPTELLIRILGQTWQDRRSVRLTSVCRRWHSIYLSAPQFWATAVSNLFFNYAKTVMVRAKDISEVTLPFEDVAVLLERSSPCLIHLDVDQHSTNVAIPVSVLPVELSVHAWRISSLSLFGTSKLLPDLPRLLETSIPALETLRIVIEDEDEELEHLELTTLPRLPAHSLPHLRQAQVTPGVLFPHFAVKSLRDVSLHGFFVPLHLSLEARDLLQALRVCPHLETLHLSEGTTPQEWPTPDQAGVVHLPSLKKLEIDDEPGDAVIGALNALSVPPTALIVIGAIETTNLPDFLPRHLFQRHPFDHVYLRVNGNKSCRSKCFTNNSRQLWDLDFNYTGPLVDLGLPDYFQAVHVTHLEVSDAWDNGPWNARRNGVDDWVAALQAFPHLIDLSVCGSDGPNLVLPALVGCTASPSSTHLPCAALTSISLGWKITAPDDHRDRPTNLPRGCDTAMYRSWDVEERIRRRCSAMQSMLEQRASRGAPKLHALEFWEFETRRWGLWRDDYSVRAGWELIPASRRDDTSSACLAQLRSLVGGPVVYRGYLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NG44</accession>
    <name>A0A4Q9NG44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_807034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NG44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="491" mass="52054" checksum="3EC3DE4D5AB163DB" modified="2019-07-31" version="1">MPVSQVSPLIAPASPPTSPNKKGKSRRPSVSSPMTWLSRTSSSASIQSVAPYAPSRPVRISEPRFANPVEAMTIPRSGVLGKGAIVVRTPQEALAGPRASASSPDLLSRVRSPTPVREYDEEDEDVPGSPPLPPIPNDDSEYIEEAALQDADVEDPETVSEWHAPSMPVTAHPPPPTRPPPSLPSIPDMHSEVAPVRSTSPLRPHRGISPLDAFPAVPPLPAAAVQTPPQAPFSAILVSPAPNSTVDPSKIIVSLETSTATHRTTMSTLTSRASHLASYLLGLFPSSESDSQSMYSTRSDVDSSFNSIFHHHLASSGVLQASTNLHVFLDRPSAPLPAATPEHPASLPHAVRLNGSSIRLEALLELRDEASYLGLEELHRLCVDELRHRQPTPSLGGLGLHMRGFSNASNKSLHTLRETSEPVDPAQRHSGDSGFASNSGSGGARKSGGSSELEVPWPSPPGLKQRAALKEGSPKKDPSATMKARPTGAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGK8</accession>
    <name>A0A4Q9NGK8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_924628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGK8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="139"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="292"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="721"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="771" mass="86273" checksum="1327BF8EC0AF6589" modified="2019-07-31" version="1">MVHGKSYICTLESLIQNFMPEHKSTSKKTVNNIFAGVPTTFSSEKAMYGCIVDRLNGSHLFPGRKFVATPYKPDKSDATKQAIDCGMYASAHAPKEEWTDLGEESRRLNWSRLELGIECKVKANLDPFDEWQDGDEPVAQGRKDVWGQLLSYADLVFRYQQRLFHYTVIFFGHYARVIRFDRSGVVASDKINYAKDGSRLTEFLVRYCRMKETNRGHDPTATRIERTDDLFDKLKKHGKKAVAESPEGHIPQLFDATLDESWPWWKLEVFNEGADGEGADGEGADEDGADEGTDTWQSFAVGKPHFLSDGIVGRGTRGYIAVPLNSSGEPTGSFVYLKDAWRVNHPGMEKEGDVLRALNKAKVHHVPTVVCHGDLPGQDTLSYNNWAQYHSDETPEKCPLKAHQHYRVVEAEVGKPLSQFANGRELVVAILCCIVAHKEACAAGYIHRDISAGNILLYKNASGQWVGLLNDWELSKAYIDDKTEEGNRQADRTGTWQFTSVHALVDHTKIIKIPDDLESFFHVMLYFAIRFLPHNCPHGAGQLLFSYFDDYSPGEAGFTAGAAKSAAMHTGEIDITLITHGKKDASGKNVDERLEFHWPRKKNADGTDDVTQPAKEHPIDPIITELLRWFKALYAQDKKPDEVLRDSSHGDDADEVLDKPDTAWLATIAAKRSSSSTSVDPHAGEPTEAQKEELRKVAEKLASHDAMEELLLQYIETRSWPARDKGADKKPKEGYSPPRDNIALTSTQVGSTKRTLDDGEVSTSKRMRSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIY9</accession>
    <name>A0A4Q9NIY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_969908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIY9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIY9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040227">
        <property type="entry name" value="Nibrin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162:SF0">
        <property type="entry name" value="NIBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12162">
        <property type="entry name" value="NIBRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="879"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="735"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1078" mass="116862" checksum="A5026191CB47AFA7" modified="2019-07-31" version="1">MWIITGPFDDDHSKGQASDKEKLLKTGREYGLGRRDQPLQIKSKAISKAHALFIVGPCSEDQAADPAFVPTLTFQNLTDRIRPIERPSQSRPRVPCQPKNSIRLENRDIVHLSASIFVRVRWETICCYNPPGKGVPHSAIEECAQLGIHVVPTFHPNVTHHLTSTYALTPSIAASLIAAVTLVKPEWLTAVLAAGRADEPGELSLLEEHCVLPPTTKHRPGFAASLPPPLKKYEVWERDERRAAVFRGARAVFVGEKGAEAQSALRELVKRGGGEYECFAAANGREAFRQVLGKGRARGAAVVPVAGKEAVVAAVGRDGWAGLVEEARSFELKFVPPEKLVEAVVYADVSYIDATCNPDEDQEDSPLPDVVPNTIEDEPSVVTSSTVVPPRRAPPPLDKEPEVVQEPEPSAAPRRRLTRRATSRASSRAPSQPPEPPSQPAVQEEPEPAATAEPAQPRRTLVRRAARPKANATDDESMVVDSAAGRASEEPQAQEAYRRPGSSVPPTPVRPSRLKRRVGVAGGTQATASAASQLFPPSAAGDDADVLVPDADVREPPLKKYKALFEESDPDRVARMGVGEYASQHLGGSGGGGESVTQYEPSVTFATQASGRGGATMTRSDGTGGRGAGAGSGLGVVMEEEEEGTVLASQTQRGTKRKTQDGGEDVEDEEHPRTRRRTGGEAGAAQNQAPPSGQSVGQHQTQSVPMSKVVTRVDMAQSQVHVKPPKPSGGKKATQQQQQQQQQQQQQQQQQRGEPDRDDAFLKAVASTKRGKKHEDTFDKEFNNLRISKPDLERVREDEEWKVLEEFGDDGDLRGNFMVVCECPVFRESGTNREHLRRGEGRPEWVGRPDFKKFKKKTTGERRQPVELVVEEESDLGIGSQYWKGSPAALPAQSQSQPHTQFQPRSGATHRLTQRSTKEPPALVLDSDDDEEPFVSKPAKGKSQAKSQAVKPPSAQKSTATRATRGKAGSQRQPLFIDSDDDVDDDGEGAAGPVDYEQDDDFRMDSDPDVGLYGEEEDDDPAATLKSTARSTRSGTQPSSKAKPATARKKAPAIVVDDDSDDGATFKAFGARSRTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NK77</accession>
    <name>A0A4Q9NK77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aip3p/Bud6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_924845</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NK77"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056279">
        <property type="entry name" value="Aip3p_Bud6_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23153">
        <property type="entry name" value="Aip3p_Bud6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aip3p/Bud6 N-terminal" evidence="2">
        <location>
            <begin position="81"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23280" checksum="7F2B4A8BB46A3D64" modified="2019-07-31" version="1">MQVPVHASSFVIGQPINPVSWPRKLPKPTYISVNTARRPASADSTCTVSSTDSSPVSPLPSSPSTSNLHSSQSRSETEVQRAVSRLLSLTKQLQEVLVRWANGAAYEEDVSDAFVLVGSQFDATVHAFYHVGVDMRDLYDVPVTLRTVLEGLLAEYPSPETLERHMPEIRTALVKLLRGLQAKQAPYWASVSRERDSTRCSTMSRVNLRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKB0</accession>
    <name>A0A4Q9NKB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APC10-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_962561</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145247">
        <property type="protein sequence ID" value="TBU52521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKB0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NKB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU52521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="24821" checksum="002C7B15617C5F97" modified="2019-07-31" version="1">MASASAVAPVIAGSIPVPGAPIVGRRRMPGGGNAAASANDGAPILHPGKLPPRLPWPDIGHLAKWSVSSFKFGFGAECLTDEDPDTFWHSDGPQPHFITVEFPRKVSIQKLSMYLSFPMDDSYTPATIAVRAGTGPVDLQDVRILQVEKPDGWITFDVCMEPNEDGDGFKHIEAYILQVIILTNHMNGKDTHVRGLKVLGPVEAKLQVYEEPFPFVSPQFKMYECIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLD3</accession>
    <name>A0A4Q9NLD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_67272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLD3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="399" mass="43460" checksum="B6C4563403311FBF" modified="2019-07-31" version="1">MSLTTSSQCPSPTFNADFWTFQIHAVQESLVLASLPAALYGIFVILTVASVYALMQRSGRLQRSSIALSLTLFVLFVSTTVYLVITLLASQSTILQAIFLSATALWGLPSTQFINAPNSATTKDYTGIQSCAGTATLTINILLGDSIVCWRACVLWRDNPLIKTMCIVFLIATFGMGIVDAVFTCNPSLSWTPDHHVVGTGSMYQGFSYGVAASVLSFSTNLLATMLVGFKAWKAKHHLRKYIVVGPMGSQMEKVFAMLIESGAVYCALWAFVVVWQAGMYQHSIALHAGTNTYWDIFGILINGALVPLIAIYPTIIIVLVALNRSHVENGLTATSQTSSNPSLRPLAVRIDRSVTSRCDHQPRESAVLFIGEQHFGSRDCTEHSSTHTSDEQKLEAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNS5</accession>
    <name>A0A4Q9NNS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_938666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145223">
        <property type="protein sequence ID" value="TBU53150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNS5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="237"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="660" mass="74552" checksum="244C3D3CBDADFB45" modified="2019-07-31" version="1">MWLLDTEKIQLQWFSSPDDVSYAILSHVWTAYEQTFQETPRFRTSGTRGILHRARDRVLHPPSEKIRNACAKARHDGFRWLWADTCCIDKTNSAELSEAINSMYAWYQGAAMCYALLDDVPNLKEEDPRSPASSFRRSRWHKRGWTLQELIAPHSVIFLSRDWEVIGSKRTLADLIEEVTGIDRRVLMHKRKVEDISVACRMSWAARRETKRIEDQAYCLMGIFGVYMPTIYGEGRHAFIRLQEEIIRKSPDQSIFAWGCILDDYHSGAFVTSAKEHDYAPQSNVETLLASSPADFSGCTDIIPVSQRSLCDRLGVGETSPEYTKSSLGIRTTFPLISITRTSFVHAALALLACEDKQRRIIALYLRSHPRSTMSNQFRVGGYIAQGGRRNPYYRATRLSVFEHSDLAVTAKIRQPSGKYARILVQPELKEVHIHSHDGTSSVGTPRSAILSSSSPRSSMVFFEPPCTIVLSPRSVQRLRDLGYLLPEIPSKGFRLNAPGDYRTVSFLAYESFTVHIGVCPLDLSSSTQKAQLWATVRFDSELGTILDDYVAKAGSSKPIGAPEREPDVIPEESMLVQSWKDGRCTFGSKGRQVRLAFSYPCADGLELDKKVSEVYELDIRFEGFYRHQGRIALERKGTISTEVTARSGGKQVAQRTFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPK4</accession>
    <name>A0A4Q9NPK4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">G-protein alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_813888</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPK4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NPK4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007188">
        <property type="term" value="P:adenylate cyclase-modulating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF360">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT ALPHA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="291"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="392"/>
            <end position="395"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="481" mass="54643" checksum="43908D539FB7A19D" modified="2019-07-31" version="1">MPSKNSKIVSEGDPLAYILAPPPNETEEQRMARLAAEAEAKRISDAIDEELQRQAKELKRAPKPVKILLLDFQLMNTPKAFRAERASWRSVVHLNVVRSIRAILEAMSDAQQHQMSLNASPTRMHAPDLTHSSSMSSIASRYRHPPLTSEHLKLKLRLSPLIQVEEALIRKLTPEGSGEIEATQLRTHGSRADRARALDKELAVNSHFAWKGVINRVLSRNSQDEEPYDPDDPVHILHACAADMITLWNDSTIKKMLRAQGIHLEHLPGFFLDSLERVTHPRYMPTDDDILRARLKTLGVSEHRFQIKEGYAGGFSRDLRIYDVGGHRSLVPAWAPFFDDMNAILFLAPLSGFDQVLAEDETVNRLEDSVLLWKSICSNPLLGKTNLILFLNKIDIFRAKLDAGIQFGQYIISYGNRPNDYDNTSSYMRRKFGQIHKEYSPQARTFYCHFTSVTDTRSTSEVLVNIQEMIMMANLQNTHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR20</accession>
    <name>A0A4Q9NR20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">AhpD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_827910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR20"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21038" checksum="A636C524979C5A7A" modified="2019-07-31" version="1">MPRVPYVPEDTPGPIADEIRVRRGGRGLSPLDTMLLNAPPIAEGWSKLLGAIRTKSTLEDDLREIIILRVAARNKASFEWVQHEPVARAAGLTTEQLARVGAVTASISGEGEGQLSSIQAAALQLADSMTVNVHFQDAEFDALRLAFVAQGDEEAVVSRKMVEAVATCAAYNMVSRFLVALDVDDRADVSCPVPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTN6</accession>
    <name>A0A4Q9NTN6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_915041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTN6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="62006" checksum="42791EE27F0E6F1C" modified="2019-07-31" version="1">MTAEKLLPAVAETLYPPPSRDLTFYLVLLLAVAPIWSVVPLSWAFVIYALHYGLIWTFSWRGWALFTVALSEVFFSVYHYNLASFISGPSPNGPGNLHDLRKAFHRVLQAGLASLPEDGYDEDEETLKVDRPGSPEETLTVLEFDDPRAVDFRNYLRTWFRRVPWSSIRRHEMFAWLYWSIFNAPFPGYDKVSQTNQKVLDEVIELLEQRAGVKIPEGSNPAAMPLLLTIDPVTVSWRPLIWYAAVTLSNALLRRRFKTKWNAKVATFKDLEYVLRIPPTWDARTGPRPIVFLHGLGLGLTQYRRFIEQLLVAVPDRPVLVPLLPHVSQEILHPRYLRPMGRHEMVEHLAGLIDELGWADNKEPTSEVSDSEDKLKSIGDRTSKGVTLLSHSNGSFGHAWLLKAHPGMITRSCFIDPVTFCSWEGDLCYNFIYRPCRNGLDLIIKYFVGTELGVANFLQRHFDWSSNSLWYEEIPNAKNPKKTMFFLGGKDSIIDANRVQRYLTSHGVRKNLRFDPSGHHGEALLAHSPFHNDILNWLREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NU64</accession>
    <name>A0A4Q9NU64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_401570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NU64"/>
    <dbReference type="STRING" id="114155.A0A4Q9NU64"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="451" mass="49719" checksum="6FC96A210F757F69" modified="2019-07-31" version="1">MYAASTTLRSTSKTVLGRYPLVPRRVAGRRTLQRFQSSSTGSGSGTGSSTSYDASHLAAGLAGGSVVLLGVYAWYHFSGTKKVVQSTQKAAQYYEQAKQAIAEKTPKDPNEALEYLRSFAQSYLVVIPGARPHIDAAFDTIDQLRDSHGDEVNRVVGDGYEEVRVIIRDSGAMDASTAMQVLDVLRRRSGELEELGKKAGKDAFGSLSEKYPQVSEKLGGGYEEFKRLAESKGPEAKKIFDDTAKQIREIFSKGFSQESINQARELVQSKTTEVRKIVKASSQEAWDRSIKEASPYLDKIPEIKQLLNDNASAFIAAGATGLTGGSSSTQELFSRIKDLAQGDALKNKEKMNELRDFVKQKAHDAEEQGSKELERGWQSLQEWIRAMPGGDEALERLPDVKVFVQVSREKGDEAKKLSKETYEDVLRVLEEKGKKAKQLAGEAQDDSKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXB1</accession>
    <name>A0A4Q9NXB1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_945637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXB1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXB1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="542"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="634" mass="66089" checksum="2E9499514068F09E" modified="2019-07-31" version="1">MATPSSSATTPSPRLRYLQPAASASTSAVVPNGHLSNDSDDRETLARRITADAHLGEYSCHFSTHLTRVSIASPSRNRAIFTLQRLLSGETLALSLRARLLYANFKVKSNTANHTLHELDSQLSAAGKHTPNGKRVANHFADPGSPSSNAGGQSSRSAARKGSMAPPPPVTASAAQSLFSSLLAPPPSKRARTIHNPEDPPVPAPEKVVEQTRSPRPPKVARTPDAHAKSKSKRAAKETASAKGKGKGKQRVTAEGSFETVTSSVEDREIDMEAAATLTTLLLNQQRPSVSATAGSPRSSISAGSDPGSTHSFTQYAQSAARTAAGGSTPVPSSSQQPLFSRAPRSTATPPHSPALSQASPALSHAVARRASTTQGSSLRPEGAGTPKMTPRDRVEDTDAADLLLHMATSPSPVRPSSLRNRDARDAAAFRTLYGGGSGPKGRVLFSSASEDGRSPRTLSREMSGSFASISSTATEPVSPRTIPARANASQVPSRLSTVHDASQSSSHGHLGIPMLPTVTPPTPTDQALPHLLPAALGANQRPAVRSPGHSSQPPSDKPAPRTPNASFSLSDYMNVSPSPAAAMLPSSRTPSGLSSQAGRRLFEDHYKVNGSAAPPQLYSKPPSSPTQHASLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZU1</accession>
    <name>A0A4Q9NZU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal S13/S15 N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_922107</name>
        <name evidence="6" type="ORF">BD311DRAFT_759373</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143426">
        <property type="protein sequence ID" value="TBU28002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZU1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZU1"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU28002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="17065" checksum="4D4A03FC676A8BB4" modified="2019-07-31" version="1">MGRMHAPGKGISSSALPYRRAPPSWLKTTPEDVVEHITKLARKGLTPSQIGVTLRDSHGIPQVRFVTGNKILRILKSNGLAPQIPEDLWHLVKKAVAVRKHLEVNRKDKDSKFRLILIESRIHRLARYYKTKQQIPPTFKYDSATASTLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8R8</accession>
    <name>A0A4Q9P8R8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_776202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145496">
        <property type="protein sequence ID" value="TBU50979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8R8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU50979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="38276" checksum="186147B7B315145A" modified="2019-07-31" version="1" fragment="single">MHTRTYAMRQNSYFRPDEWNFLLAAVLDQEVQEYLDKGSYTKARALLSARFQEHFTSPSAGETEEAFKQRLRFAKKGRKGDIVRIRAESQEEWDARMQQLNNQLKSWLYNYRAKCRRAGVKRWVAPPVPPIRRHRKRALKAFDMFCKSDTAPKGADFVTNKGQRFDLSRLQAARKAAWDHLSDEDKEVFQRAVAETLREADVLPELVEIEGSNAPVAYAEDIAAHVDDFFEGLHEDVKWGGFAMFGGPDHDGEARIHFTHAGTNRNGQSFMDALLQWLGLTQLEFETVFSLWVEQSRQGPQANDEHVFAESARRAIEHCRAQAAATHTGNTSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8S4</accession>
    <name>A0A4Q9P8S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mov34-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_836077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8S4"/>
    <dbReference type="STRING" id="114155.A0A4Q9P8S4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="291"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="293"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="330" mass="36657" checksum="211CC51ADA3A0EAD" modified="2019-07-31" version="1">MVATTTEQLSALSNTTVVVHPLVLLSVADHHARSVSRGSSKRVVGILLGQDNGTTVNVANSFGIPFEEDDKDSKTWFLDHNYIEGMWEMFKKVNARERMIGWYHTGPKLRASDQEINDLLKKFIARPVMVIVDVRPQTVGIPTDAYFAVEEIKDDGTETRKTFLHVPSAIEAEEAEEIGVEHLLRDIKDSTTTTLATRVAEQLASLRGLQSRLSDIQSYLTEVAEGKMPLNHQISYHLQDALNLLPDLNEPELTTSFATTTNDEMLVVYISSLLRAVIALHALVDNKASIGRAELEESKGDKKEEKKTAKADEKEKGEKEKDSSKNSTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9Z8</accession>
    <name>A0A4Q9P9Z8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_965140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9Z8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9Z8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="202"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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    <feature type="region of interest" description="Disordered" evidence="1">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
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            <begin position="1162"/>
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        </location>
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        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
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        <location>
            <begin position="96"/>
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        </location>
    </feature>
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        </location>
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            <begin position="1105"/>
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        <location>
            <begin position="1167"/>
            <end position="1187"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1187" mass="126985" checksum="4A5CB31218B1A980" modified="2019-07-31" version="1">MVPSTSTAKPSVPSFDPFTRSDSIASSVQSAGLRRRSRTRTRSLAPSKRGRSQGQSAGSKYESDSCESFLDLDDVPPVPTVVYDEPEEMTAEEKRRVKQARRRSRTVGPESRPEPGALRQDMPQMSRARSAVDVREVPFEQIRGRQAKSDTGSIKAAKAKLRGLSLPRRNLRQHSPSDESSQASPLTPFGFGEGAAVHIVSRSSNPRDSILTQNSTTSSSLYPASTSVGTRTESSMPYTYDEGDLSYPEIVTQDHSEFDPDDVSYRLRLLLNNSYFLPPAHTKPSPFSLSPLSAEAAKKAKPANAGFLDFFRLGKSKSKPTSPVPGSPPAVDNAGPILRTTSDTPTASDFLLRAQQQPLIPPPVVPPASRVVVLRERMDDLATAAKESEKELRSRDTRKTKTQTTPRDRFVDDIIDPTDAVDLPPQLVDSMFAVQASAAYGLGPQESLNAAVLADRLVPGSPGIWSISSEEESWRKDLLHQAVSHSLADTPDHSFSSSASSRAGWPLASPPPQSEASFRTPAMLEVQKAKVGQRIVENLSIHSESSSKSPPLSPSVGQQPPVQSMPLSSGEKSPLAAEHPLLSIAGPPARAETPAHMPLPLAPAPRKQLFNPLYSLSQPDLSEPVAKVGDAAPGSSSASYHTVRKATSTPGLSGAEDHVAEQPTVSLSPPPLPVRGISPELRELEGMPSFTTATRSRSESESRYSSDEMSFRTPMDTDVEHSGARPSMTLSLPSGRPSISVSISEYSMPSPTASAFGDAVFGSCRPPSVMSRRSIASHVAPSTHSLPELPLHPPITPRSVTSPPPRISSSVSPTELPIPPRPRAARPTYRPSTSTTNSRSSNSRSRPPPDSPAVSELGPTQEASINLSYSSASTASSPSAPLAARRGLGGPLTLTIPRGMQRPIIHSAPAPASPADFFDQIQTTFHNAMDDLDTSDESESEDELSLDGAENARSRFNPGPPGETPTTLRTQPPTPGGENVETAEVFVEPRTQAISNRASSSSARPSIMRLGNHSTPQLSPASSRSLQEPLPQFTYDRKKPISNVVDFNRRSSTSSRSPFSKKGKGIAHVPTSPLLPIGALPSSPIAPGTSFGRVSVSSMSSAVAVSVARSTESVSSGRKRPATAPDDKGKSRAGERKPQRESILRFDGMLTQHLAAERDRMKRITSDYLSPSATSSPVQTRPSLQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC00</accession>
    <name>A0A4Q9PC00_9APHY</name>
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        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_832626</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="TBU52259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="50445" checksum="4AB22C24C4A73036" modified="2019-07-31" version="1">MDDDICAYSKHTASRFPVEVCENIIDMLYSVYLIDQVEHSRALHRCALVCRAWRVRSQRNLFYAVVLHDLAAIEKLSTVLDNAPHLCEYVHEVTLIGRTLHTTASPLSLLPIALRGKLPKLQAVTIKHVSEHEDWYPSASELESKSTKSLQYLPLHPRFSLFFSAFTSLATLQIYESTFRHFSDFARMIDSLPALQILMCIEVRCMALGSLPFSMKPRADGVHAPARPFAPNLQELFLFDMDVRCVQRLVSACGPQLRQLSVTMPFCHDAEMVLPGDPATEHTEGVDLTLCTTLEGLDIWLFPHFVTDGQSPDKLKAMLNSWESDSEGPLRRIYLQPSIPSIFTRQDFADLLGTVGRAIEEVLHESSAPPSADGEVGEQGGRWRIVIHLNDWEVWLDWWRAHVQECFPTFARSHGLGMYYRPPANFNETKWKDSNALPPMPITNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDC5</accession>
    <name>A0A4Q9PDC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145242">
        <property type="protein sequence ID" value="TBU52658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="22612" checksum="93976C3AD15CB87C" modified="2019-07-31" version="1">MNYTGISIEAFVLLPTGRHCARYASLEPPPRARPHDIAAPTARVSLPPGTPTQPPEHDEPAQIPPAWTELRARHVPDAPRPVCVVRAEPEPRHARRHLLDAVLPDSTVALRFSGELVARLEAYDAVRMPCLRHVTPHGVTGSYFDRHPVDRCFPDAHLESFLHALRVRNHHLESLAASYGPRLRKLVRLGCSRLSSTVITQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFC7</accession>
    <name>A0A4Q9PFC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydroxymethylglutaryl-CoA synthase</fullName>
            <shortName evidence="3">HMG-CoA synthase</shortName>
            <ecNumber evidence="3">2.3.3.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-hydroxy-3-methylglutaryl coenzyme A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_937505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>acetoacetyl-CoA + acetyl-CoA + H2O = (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10188"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57286"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. HMG-CoA synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.10" evidence="3"/>
    <dbReference type="EMBL" id="ML145207">
        <property type="protein sequence ID" value="TBU53690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFC7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004421">
        <property type="term" value="F:hydroxymethylglutaryl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006084">
        <property type="term" value="P:acetyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010142">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00827">
        <property type="entry name" value="init_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000008">
        <property type="entry name" value="3-hydroxy-3-methylglutaryl coenzyme A synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013746">
        <property type="entry name" value="HMG_CoA_synt_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013528">
        <property type="entry name" value="HMG_CoA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010122">
        <property type="entry name" value="HMG_CoA_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01833">
        <property type="entry name" value="HMG-CoA-S_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323">
        <property type="entry name" value="3-HYDROXY-3-METHYLGLUTARYL COENZYME A SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43323:SF2">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08540">
        <property type="entry name" value="HMG_CoA_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01154">
        <property type="entry name" value="HMG_CoA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="470" mass="51249" checksum="0A606F5182382F7D" modified="2019-07-31" version="1">MTVPLNASTSQDVDAPPRPKDVGILAVEMYFPQRCISEEELEVFDNVPKGKYTIGLGQKFMACCDDREDINTFALTAVISLIEKYNIDPKSIGRIDVGTETIIDKSKSTKTHLMDFFAEAGNTDIEGVDSKNACYGSTAALFNAVNWVESSSWDGRNAIVVGGDIAIYAEGSGRPTGGAGAVAILIGPNAPLVLEPIHGTHMANTYDFYKPKLDSEYPEVDGPLSITAYISAIDASYAAYRAKHAKAKKAAGLSGPAFSLADVDYPVFHSPYGKMVQKAHARLVYNDFLANSDSPKYAQVPDREAWLAQPYKASLTDKNLEKTFIAVAKADFEGTVEKGMRCARRCGNMYTASLYGGLASLLSSVEPAELKGKRISMFAFGSGLASSFFTIKVKGDSTEIKEKLDLVRRLESMKVVPCQEYVDALTLREKNHNAGSYVPEGSLDNIWPGGYYLESIDSKYRRKYVRAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFQ0</accession>
    <name>A0A4Q9PFQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1000745</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145273">
        <property type="protein sequence ID" value="TBU51987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFQ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25492" checksum="50E5FF000E485FBB" modified="2019-07-31" version="1">MHPSATSHATLEQPLARPPTTISWTTEYFTKPPPYDACDTAALMAAAYADKSSSQRRPQDVAPLAGSFLRGASAAPWISSPRRSALYLLIPYLPETILSAVRMHSPVQCMPNDPLSSIFSIAVLDEEDEDLLTFSNLMLMCPCWGEVAINSPMLWTCIAMERVARANGDRNGFAYTHTDLSTVETLEILSGGSQLMRLENECLAERLDIACLGFAITLTLVLPLLPSVGGVEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIV4</accession>
    <name>A0A4Q9PIV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_110772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU54000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIV4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15121" checksum="DD523DD25234A81B" modified="2019-07-31" version="1">MRARRTSSAAWCAAAERTSSGLSQIVARAKVKTKTSPIHRILRAMLSGYMCDFSASNLSPHCIHIAARPGCHSRATIRLSIAARDGIGITRDTPMLDPQPAPPLSFLGSCCLRARAYDPRTRWSTNTALPSLRCHYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJM8</accession>
    <name>A0A4Q9PJM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_951544</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145192">
        <property type="protein sequence ID" value="TBU54301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJM8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="145"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="282" mass="31329" checksum="FA9C04CF5FF3C5A4" modified="2019-07-31" version="1">MGNPARVRDLGWMPKATKGSSKKPASAPFGSKASSKTQKNPLFESRPKNFGIGQDIQPKKDLTRFVKWPEYVRLQRQKVILSQRLKVPPAIAQFSHTLDKNTATQLFKLLNKYRPETKQEKKARLDALAKATAEEKEAQTKPEKKPLFVKYGLNHAVALIEAKKASLVVIAHDVDPIELVVFLPALCRKMGVPYVIVKGKARLGTVVHKKTAAVLVLQDVKSEDQRELATLVSAAKANFTDKYDEQRRQWGGGIRGAKSTQMLRKRAKAAGQTLSVANAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJV5</accession>
    <name>A0A4Q9PJV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_828132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJV5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="286" mass="31374" checksum="25BB410B807C5201" modified="2019-07-31" version="1" fragment="single">AALFVHDFNLTFDSEVALFWTGGHLSGATVLFLLNRYITLASQVMGLIPSSSVVRVCHYVYVAVTVLEALQYLPWAAFSALRTYALCPDPYRWLISVSVFALSSVPIVTEMWGNLYGLSFVNDPVLGIISISPISASTNLKSDVTVEVVTRSCLIASDLVVVCVTWLRTYETAKLSLGRLGKRSFASILLLDGMYQRSSLQPDEHSYQNPMFLFSLTSILTSRFLIDLQKAQRKLAGSSQSVSLGEVALQPQTSGNTSRLIGSLGAQLSFHEVDEEEEENEGEQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKU8</accession>
    <name>A0A4Q9PKU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_969596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKU8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="269" mass="29070" checksum="CF5FB7FAE86B6E4E" modified="2019-07-31" version="1">MPSYAVFGASRGIGLEFVRQFAEDKDNQVFAVVRSPNNSPLLAEAIKTLKHNNVQIVKGDLADVTSIKEAAAEIGNVTGGSLDYLINNGAYIYTEGVALSLPDYPSEKLLEDDLLNTYRTNVVGVVHAINAFLPLLRKSAIKKVITLSTGLADPDVIIRSGFTVNPAYAISKAAVNLVVAQYAGRLQEEGFTFISLSPGLVNTATAPPTPEQITAYQDTVNKLKKHSPHWDGVPLTPEQSVKYMRQVIDKVGPKDSGASLSQFGNKQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM52</accession>
    <name>A0A4Q9PM52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_826155</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM52"/>
    <dbReference type="STRING" id="114155.A0A4Q9PM52"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="28"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="321" mass="35215" checksum="15B9627697E286CE" modified="2019-07-31" version="1">MASSNIKCFQLNTGAFMPAVGLGCFMGPTQTGESEHVTAMVKLALDLGYRHFDTVNSTCNESSVGDALRGTTVPRSELFLTTKLDQKDHGRVREALHASLTKLGVDYVDLYLMHWPMAYDESGTSSHSGKTLQPDEKPTFVETWKEMEASLAEGTAKAIGVSNFSVKTLTELLNHTDKVPAVNQVELHPSLPQHELLAFCRERGILLTAYSPVGKFKFADDPEITAIADAHHASSAQLLLSWGVQRGTAVIPKTVHATRMRENLQLFNLTQADMEALDAFHKKPGMHRSVCGFHSAELGGSCWGWTYEQLGWQMTVGGVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMN6</accession>
    <name>A0A4Q9PMN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_681349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMN6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19386" checksum="960D2FD260868EA1" modified="2019-07-31" version="1">MLSWAPSIFVLSTCVRRRIRQNPGASTRAQTCLNGAVITSEQQRHDTTFRRACDALLANWTCSKSCWPGRPKSTVWSAANHHGVGESSIHRSVSRRSALGHAQCRHLDNPRFFLQVCGSDVTRQIRCSSNKYPAQRRDHVILCASAWFHTDGGPPSSAGSRRGLVGLPRRHVANT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMP2</accession>
    <name>A0A4Q9PMP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1029167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145169">
        <property type="protein sequence ID" value="TBU55426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMP2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="216" mass="22813" checksum="5880CE91A598E72A" modified="2019-07-31" version="1">MSLQHLPLNAALAAAGLHADVHTATSEYDTLKYLELRLEAETRHEVGEYLEAERISASMSTRRSIISSWSASSPWSGFGCPARGPILSRTASAILRLRLASMRQATVENFIMSEGGAADGRALKGAEEMHSPSPMGIFRASGDHQHAPTELDKDTRAAGVTPAPILNCVLGSVDCSRQATYGTGGSEGAKSKVPKLLANFGKSPGLAAKTRNGPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMQ8</accession>
    <name>A0A4Q9PMQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_1041117</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29535"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="Rhea" id="RHEA-COMP:19518"/>
            <dbReference type="Rhea" id="RHEA-COMP:19519"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:132517"/>
            <dbReference type="ChEBI" id="CHEBI:132519"/>
            <dbReference type="EC" id="2.4.1.260"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29536"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMQ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMQ8"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052917">
        <property type="term" value="F:dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF1">
        <property type="entry name" value="DOL-P-MAN:MAN(7)GLCNAC(2)-PP-DOL ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020564341" description="Mannosyltransferase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="221"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU55445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="529" mass="58263" checksum="F05CC9AE74DA6615" modified="2019-07-31" version="1">MSLALDLVILLTSLSHVSVSPYTKVEESFNLHATHDILMYGVGPSNLRKVRTAFSYDHFVFPGAVPRTFVGSVALAWLSDIVLRIGVWFGLFVGKFDIQVIVRMVLASANAVGLIALRRAVSRRFGRSTGFMFVLLSITQFHLPFWMGRTLPNMFALLPANLALYKLIDRAPNSTRPSKTNVQWAIALLTFTTVVFRSELLLLLGPLALQASLRYVSVYDVVKAGFLSGLASAALTVSVDSYFWQQWPLWPELYGIYFNVIQGKSAEWGVEPFHRYFSSYLPKLLLSSLPLSGLGFVLEARVRSLLLPYLMFIGIISGLAHKEWRFVIYVVPAFNIAAARGAAWLVGRRKGSIFGQLCFLAVIGMLVLNAVVTFLSTQAAAANYPGGAALQTFNDHFASEKSVHVHISNLAAQTGASLFLHRNAPPFYPGLPVPPHTKWVYDKTENLSLADLTNSQNVTHLIAEASALEGNKHAHGWTPVALIAGFDGWRFHGRYGLRAVLAEGLTGLGNMLEMRRSGKLVILARNGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMZ6</accession>
    <name>A0A4Q9PMZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_979564</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMZ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMZ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1730.10:FF:000006">
        <property type="entry name" value="Urea active transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="587"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="532"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="677" mass="71914" checksum="30FCAA6CE266E721" modified="2019-07-31" version="1">MSANEPILPQGAGYGVVVGIGLFFSAFMVVLTAIQARYTGFSPKSSEEFNSASRSVKPGLIASGIVSAWTWAATLLQSSAVAYKDGISGPWWYGAGATVQVLLFAQLAAKLKLNAPHAHTWLEIVAARWGTVAHFVFMFFGLATNIIVSSMLILGGSATVNALTGMNTIAACFLIPLGVAIYVVVGGMRATLLCDYTHTSVLFAIIFVFIFTVYATSPKIGSFSAMHDLLAKASAEQPVAGNAGGSYLTIRSKNGLIFGVINVIGNFATVFQDQAYWQRAIASRPATCVKAYLLGGLAWFAIPFMFSTTLGLAAVALRGDPDMRILSAADVSAGLPAPAAAAAILGKGGAAALLVVLFLAVTSATSAELIAVSSILTYDVYKKYFNPTATEEQILRVSHAMVALFAIVMGFLGLIFFYIGISMGWLYEFMGVVLGSAVVPIAMCVTWRKANKWGCIIGAIAGFCMGVMAWLVTTSALNGGELTVTTTGGDLEMLAGNLASIGVGGIVTIVVSTIWPENFDFEATRAINRPGNSQEVEKHLEPSREGSVDEKKRDSTEVSIEPMSEEAAAAEEERELDPVALNKAFRLAAWASVVLTLVMLIIIPFPLFFAQTVYGVGGLTAWVVIGMIWAFCSAIAVVLYPLYESRQALFMITRGIIKDIFAKRSGKFVHSEKPLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNG9</accession>
    <name>A0A4Q9PNG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_654218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNG9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15271" checksum="434B777E7F789BC9" modified="2019-07-31" version="1">MVSRALPGSPLLIMGVCGSGTSLCRGSRVPESSYNPVYSPAYSYHLSPPTRSSPRSARMNTRVQKHTVKGPSGRSDRDAPAWQMSRSTINTSSVPRRAGSIWHLSAVVLGDFLPLELSSNSPICSHSQWTPREAASAFQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNU8</accession>
    <name>A0A4Q9PNU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_932593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNU8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16860" checksum="8898E1AC6AA1B46D" modified="2019-07-31" version="1">MSFISQHTVNRQNAPGDRTGFHGFSIGPQPGEQPDSPENLLNIRGRKTSFVRSRNRRQRSACHMAGERILFSLGDSILTCSSRRRICEQRSSSSQLGTNHHRGRQVAKTTRPRNGGSGRCPYSVQFQARIFPESLCFSGSTFPTNPFECTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP93</accession>
    <name>A0A4Q9PP93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1026335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU55995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP93"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="13071" checksum="C66DD8DBE8CA2824" modified="2019-07-31" version="1">MHEEGSDPVNGKLQWFELDVEASSKIKDVAAAFLEEEGRPNVLGEMMDTVAQCITLGDMLICRCERTYLTKVVKGCEHPMCWAREVCPSDTDDWNKEYTSAKNPIVGAKKDDQLRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPB6</accession>
    <name>A0A4Q9PPB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BBC1/AIM3 cysteine proteinase-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_932087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPB6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPB6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BBC1/AIM3 cysteine proteinase-fold" evidence="2">
        <location>
            <begin position="349"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="559" mass="60368" checksum="828F599B78495863" modified="2019-07-31" version="1">MPTFAELRNKASKVADAGASRVRNTRDHMSSQPSKNINWDAQIKPRPPPPPKPPVPPPPPSRASSASTGLAGSPGQGKPPPPPVPSRRAGTSASPAPSFSKSISSTSNKSLVSPLPNGPPPAIRRDTRPDLPSSSPSPPVPAPIARPPPPPSRGVISVPQVVTQNEDAEIDHIDWENLSPEDKEAFFSWLDEFFARYLNVSISPRAPVETVKHIPPGGRTPSPMTGPPSVPRSSRPQTPPRPGSDSGALTSYPPPTEHGSAAADLAHYFSSSAHWPSAWYASDDTRPPPLRNNGQTMWTGRWRSDGSTKTVEGSVIFSDLSMCWYSVSWPQNAPPTHDANDARTVSRTARYLPRPNPWTKEQLVDAHETYGETIAGYAESYEGTGVPCARGECWDLANEAIKYFEQYDYVPKPVPSISRTHGHLIFEGKASEKGRNQAGRWRGGDDRVRRGDIIEWRSARVGMGPHGWSTLGNPEHTAVIVSDCVPRTSVADGKAVRPAEVGVIEVVEQSVGSPPARKSYDLANFEEGEVWIYRPVGMEAYVGALLTPTCPEGVDALSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ36</accession>
    <name>A0A4Q9PQ36_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase 61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_950110</name>
        <name evidence="9" type="ORF">BD311DRAFT_781080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143482">
        <property type="protein sequence ID" value="TBU24325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ36"/>
    <dbReference type="OMA" id="LFFGFWR"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF38">
        <property type="entry name" value="PROTEIN O-LINKED-MANNOSE BETA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="8">
        <location>
            <begin position="103"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU24325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="411" mass="47470" checksum="16A26D9985262F0C" modified="2019-07-31" version="1">MKNRNPILNESTGWTIFDRLYLLNGTLYVVTDEPESVPDRLYILSSAAFITNDPEEALLRAPTDKNMRVISTTEARQLFGTEADRLDGVTWLAYDPKQFITHYYHWSAELFFGFWRTYSSLDPTIPPSGETSLPAPRRMIFPHLDSNNWRDYAKMNQWVVRAAFPSLSMEFMNDWKERAALARPYVLDRVVLADRAAAMNGEMYLRTQRTAANAFALPGSVNWWTTIRNNVVGFSLQGEATDAAAVQGIETRPVISYISRQGWNRRKLRQEDHERLVEELYRLRDEYGYEVNVVEMDKLTRMEQFRLAGRTTIMMGVHGNGLTALLWMRPTPRSTVMEFFYPGGFAHDYEYTTRALGMVHYGFWNDRHFTRPDVPLPAYPEGFQGNEIPIDGAAVARLVRERLTLAEEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRB4</accession>
    <name>A0A4Q9PRB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_949797</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRB4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9344" checksum="2F32496EB94CDE0A" modified="2019-07-31" version="1">MVNSASAEAYATLRAGSRPPSRAVFRSRRVRKNACTTWLTWLEAFHRLSYFRRVESRKRFNAGLHRKSVDDLAFGTGRLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRQ0</accession>
    <name>A0A4Q9PRQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Glutathione reductase</fullName>
            <ecNumber evidence="3 16">1.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_930248</name>
        <name evidence="19" type="ORF">BD311DRAFT_765816</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
            <strain evidence="19">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 16">Catalyzes the reduction of glutathione disulfide (GSSG) to reduced glutathione (GSH). Constitutes the major mechanism to maintain a high GSH:GSSG ratio in the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 16">
            <text>2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58297"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.7" evidence="3 16"/>
    <dbReference type="EMBL" id="ML143472">
        <property type="protein sequence ID" value="TBU24806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRQ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRQ0"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000003">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000235">
        <property type="entry name" value="Glutathione reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006322">
        <property type="entry name" value="Glutathione_Rdtase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01421">
        <property type="entry name" value="gluta_reduc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004776">
        <property type="entry name" value="PRK06116.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF2">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="5 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="18">
        <location>
            <begin position="12"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="17">
        <location>
            <begin position="359"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="192"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="50"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00056905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU365016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU24806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU57062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="472" mass="50974" checksum="BEBD28C244BBFFCA" modified="2019-07-31" version="1">MPPVTKPGHEKYDIVFIGGGSGGVAGSRRAASYGAKVALIEASERLGGTCVNVGCVPKKIMWHAADIADKIRHAEGYQFKGPGIGQPQFNWETFKPQRDAYIRRLNGIYDSNVAKEGVELHHGTARLTSRTTVQVTRPDGTTYELKTDRICVTTGGRPTIPSDDDIPGASLGINSDGFFDLESQPRRVAVVGAGYIAVELAGVMHTLGSEVTMLIRGETVLRNFDPTIGETLTNWMKHTGINFRHGSKVKKVEGAKGQTLTIHLEGGEKLEVDTLLWAIGRHANTEGLGLEELGVKLDERGNVVVDEYQESGVPGITAIGDVAGKALLTPVAIAAGRRLSNRLFGPAKFKDQKLSYEDIPTAVFSHPTIGTVGLTEPEARKKYGDANVKVYKSSFRALYFSMVDEHHKEPTVYKLIVTGPEERVVGIHIIGLGSDEVIQGFAVALKMGATKEDLDNTVAIHPTSAEELVTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRS5</accession>
    <name>A0A4Q9PRS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_929980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRS5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="244" mass="27096" checksum="E832C136D653CA60" modified="2019-07-31" version="1">MIQNGQITFYTHVYSPYCHRVHIALEQAKADYTSVCINLMEKPEWYDKKINTVTGKIPALTYGGPKHPPGEPSPEAAVLVESGVILEFLHETFPEARLLPSDPILRANARIFVSIVDNKLMDVFRGYFVEGAPASALLAGFEALQVRLPPVGADGKGGFAVGEWSIGDIAAAPLLARIVMLLEHDIGRFEEGDGPKTLALLRGPKYARIMKYLEDAKRWPSFEATWDEPTVLAIWQSNPFFKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSA6</accession>
    <name>A0A4Q9PSA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_822082</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSA6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="2">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20803" checksum="5D18BFCE0446599A" modified="2019-07-31" version="1" fragment="single">MTPCEAFWGDKLNVAHLHPWGCEVRIHSPGGSKLAARAQTGRWVGWDEATDAHRIYWSDRRIVTVERSVRFKPDDNNVEVELEGEQDQQTEGQQEETHLKNGELVPTTSPVGADADPTTPAGTDADPTTPSTDGLLHDPVGLTHAPVATSGRPRRVQKESDYVRRLRSGEGSMDGRGRTTLPRGMSSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUP9</accession>
    <name>A0A4Q9PUP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927683</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUP9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6569" checksum="3E34681EB893834F" modified="2019-07-31" version="1" fragment="single">VVLCSVHVYHVVTTLGTMMLSSLSAHATSCHIWNVSLQVKPWLGPGQGVGAQLAGSRLSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVF7</accession>
    <name>A0A4Q9PVF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta hydrolase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVF7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="140"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="452" mass="51131" checksum="3462C22710A2E962" modified="2019-07-31" version="1">MAPPEPHASLARPSTAAVVPHRSVHPRRLAALEPPPVTLGNYPLLPHSRNGYFFADFHVQTHVFPAAFPRCPSGIWSPPPLRESPEERKRRIHEVVALSSALKEAQEQGRDSRVPLRQVYWTVANRYFRRSCPTTSGLTLVFLHGIGGHKETWEPTLKRLLELSATGNSAFTIDEIWALECVQHGDSGLLNEQVMGDTFDCAEYARDATNFLLSYLPECTNLAPGLLPTNLPRVPERETLQRKSNGVCGRTIVGIGHSIGACSLVYPAVEYPALFSSLILVESFTIPEFIKHQDAHRRNEALSLSRRYVWSSREDAEQYLLKSPYYRDWDARVLKKFIQYGLVDLPGGGVRTKTHPFLESLMYFERRVVYETWELLESIDPSIPMHWVWGGRSGRQGGQSVQAQTTFRRGPNSTNDYHSDVGHLFPQEAPDLLASDIHRFLLNTYRVGRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWW3</accession>
    <name>A0A4Q9PWW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_877419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWW3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="27"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="5">
        <location>
            <begin position="237"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="652"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="4">
        <location>
            <begin position="771"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="867" mass="97397" checksum="592A3F95F1BD0AAC" modified="2019-07-31" version="1">MASKSANAIQILDIHTRVSPSSGASIRDQIVSGLSQPVGGKTLPTLLLYDERGLRLYDEITTDAAEYYLFPAEEEILKNKADEIVRVMHSGIANGELVDEVVVELGAGALRKTSLILGALAHLVPNPAPTPPISYHALDLEKRELERTLMELNSSHVGVELKGKVATAGLCGTYDDGLKFIVEGGLQDRNALERIDTAFGSQYPVERVGRDASPSSAASSRGRTDGTEATPPSTPGAQQPLHILFLGSSLGNFARGEDAAFLKSLPLRPGSGDTLLLGMDHGNDARRIEAAYNDSKGVTRKFIMNGLVSAGRALGDESLFDQDKWEYVGKYNEESRRHEAYYRSACDQTVVDPETKAHFPFVKDELIRVEVSHKYSERDAWTVFTEANLRPVHRWTDRSSQYSLWLLERPKFSFPLLKWPSSSDAKTVARSPFSLPTVDEWRDMWAAWDFITRQMIPPSMLFQKPIDLRHICLFYCGHIPAFLSIHLSKLLQEPDTEPVEYKYIFERGIDPIVDDPTQCHPHSEVPQKDEDWPSLPSILQFQSRVRERVINLYRDIDSGKVTLTRKIARVMQMTLEHEAFHAETLLYMLLQRAGTGTIPPSGFIPPPWEVLAESWDKQPLPAAETVTLGPEEISLGHDDDESQDDSTEGVLEHSFGWDNEHPKRTVKVEKFKIEWRPVTNGQFYEFYTGPGKDKVQFPKSWVELDGEVFVRTLYGPVPIKIAWHWPIKTSYDNLSVYANVKGGRIPTEPELRLFLDKFECGYEGGANVGFRNWHPVPATTGGPADGGKGHNGGVWEWTSTVLDKYEGFVPSKLYPGYSTDFFDTHHQVVIGGSYTTIPRLAERRTVRNYYQHNYPYAWVGARVAYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX20</accession>
    <name>A0A4Q9PX20_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_967181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX20"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="604" mass="67782" checksum="E590AC67C169ED58" modified="2019-07-31" version="1">MPPKTTGTAELTLPTLGTMNLARAFHEQVQSLRSSSRLGKGEMHVETLEDLYNLAENSSIALRELVNGYRPINRLPQELLAAIFSLVPRTHPFARDGLPTFSSNKMLQVSDLLPIVATCRRWREVALATPSLWSMIMDDSNQQAPIYTHYLHRCTRGPLRFLLGPRASPRTILLLSEQGHRVQEVIVQLVSFSTFTTIVSTPLPDLRHCTIRNCLYGVRTAPVFPSGCPSLKTLSLQAVDFVPSSGFPSLTHLIISSRPTTNPTFNMCHLFTFLSECPSLTTLYLDGLEHADMSLEGWQGSVTLQNLQRLVLLTRYPHEYPGGATGDLYVYRAFFTHVLISSTCVIRLGELRPRELSTCLDLVGLTDGPTAWRIYPDKKFTYVQHYNVYCIQVFNITQSRYLQLDVATPFQVNPEDNLDLSAALAQSSVFVNARGVWIAAEAERLLRTPSPDTLLPRMSQLESLIVCRDWSRKANLRERKTLKALEAPGDTASEDLACPRLSTLRVDCLTDEDAVYMLQLAFSRAAAGHPLTRVILGRGIQTMSALGMLHQYDGAGDVVRTGDVRSDGLWDHWMSQLSPVCLDESEDCAPYWRSWRWDPWGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX70</accession>
    <name>A0A4Q9PX70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1011687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX70"/>
    <dbReference type="STRING" id="114155.A0A4Q9PX70"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="224" mass="25320" checksum="A5FBF34F9E18A5DB" modified="2019-07-31" version="1">MDSARIYLGGVPDSLSGEEIYKHLSVHGRITEIKLRPGFGFVQFEHRREVVRAFSNQPFLGFAINVQLARPERYARSPELEYEPPSAPPAYHQQDRPKKMRYAVVVNGLDPRTCWQELKDFGRSVGGEVAFCDVDKDHRTRGWLNYAQEEDANRAVRELDGTRLLGNVVRLQRQASRPYALCPREAAVCGRADTHSTVAVSQRRRVQPTHAEGGAVRVRVPSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXE0</accession>
    <name>A0A4Q9PXE0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_423821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXE0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="185" mass="21323" checksum="F4F9283502F2C605" modified="2019-07-31" version="1">MFGVGRERIIGVVRVHDYGAILGRFWRTILEVILFSESRFWQNRAESQKLLRRSFCPPESRFCCPRFCLPQNPPQNRDHNRSQNLPSVWGGQSRPRFRHDSDIKNRLRIAWRIASESRTLTSPNCTWSGSIVLEHLSPCTKPGEFDCEPELTAPRTIPGGPFIFPHFRCVVKAAVEDSRCTLATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY00</accession>
    <name>A0A4Q9PY00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_407532</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY00"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="175" mass="19752" checksum="89B61E3C500B18CB" modified="2019-07-31" version="1">MPHPCNVSSPFCSRYLCDCASHYQRIPPTLHRHSLSRWAVVRTRTVRIVGYVGMSSYPEACILRLDIQMMHLCGPNAHPGSRRYTIRPLSIWQTSNCQKMHARDPALCSLETGEPRVTCLFSQASLVLYYYSVCLFSSKRGDTHGYLSVSPRIMALGRRTDRATRSVRADGPSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZE1</accession>
    <name>A0A4Q9PZE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Six-hairpin glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_905635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZE1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF6">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE SIX-HAIRPIN GLYCOSIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020393174" evidence="1">
        <location>
            <begin position="18"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="218"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="543"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="649" mass="70105" checksum="25381CD3D00AEB7C" modified="2019-07-31" version="1">MRVLYPTPLLFATAVAAVPCQQYILAPPSRNLRPVAVRLQSGSLSAATDLLDSQVSLSLILDTFNSSVTYDFGKNVAGSVNFNTTSNGGALGFTFTESSLWISPEASDATADAGSDAPLVFNLTAAGHYAAPIDRERGAFRYLTVVNLGPGQVSINDLWVHFTAMPHWRADSLRNYTGWFHSNDEKLNRVWYAGAYTNQLVTIDPTRGDALNYLNVITSNSTVIGTLDWWLNTTITNGTSTLTDGAKRDRLVWSGDMSIAVPGIAVTTFDLISVQNALDSLYNLQNASGLLPYAGYPFNKLGIVSFTYHLYALIGVESLFHYGGDRSYLDGKWAQWKAGMEWAVAQIDDTGLANVTASADWLRFGMGGHNIEANSILFYTLNLGVALARHQNDTATADHMGLFRDNETTTLAPQDGNSWAVKSGLVTNVSQVVQILNALQGRWGQYGAPAPEAADAVSPFISGFELEAHFAVNRTTAALTLIRNMLADFMLDDPRMTNSTFIEGYSTSGELRYAPYTNDPRISHAHGWGTGPTSSLTTYVGGIQLVGAAGATWAIVPQVGDLTHVDAGFSTTLGRFSSKWFTNGSVFRLEISTPKGTTGTVGIPFPGNRMTATLIRADRPGVHVTADDLGRYWITDLAGGDHQFVVVGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZJ1</accession>
    <name>A0A4Q9PZJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_876078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZJ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17571" checksum="5F8B152ADFAF7270" modified="2019-07-31" version="1">MADCIAIGATWYTLARSHGIHQAGMIKESISSVLLNDGTIYFLILAILNTLHLTFTYLSIAEPAMQITSVITNYTIPLTAVLISRFLLHLQSASLRAAGSMASSQVSSMDLNNSVIFERVIGSLAASITMDDYIRQEDGRAENVMSISTEDEEEPTHTSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZP0</accession>
    <name>A0A4Q9PZP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_923186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZP0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SigF-like NTF2-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="253" mass="27556" checksum="A65EA1E9B5D3F576" modified="2019-07-31" version="1">MQKPEKEIVAVVLALTASPDPDVQKRAVEQYYAPDVNFRHPLCSANDRTGLLAIYQWYRIMSPAHSVTVSSVTFDQQKLELFLDVSQTFHLRWSPLAPAPARLVVHLRLRPADPRAPADKTTYLIAEHEDFYHQEDLAALLVPPLVPLVRAALSTATLACRVLSFGFSRVLGYWRVRDGDGEAGAQADPRGGEHGGEQELRELRNGKAVNGTGTGTGSAGGSVKRRRTSAAGSYADAAREAVAEMQDKGLNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0E1</accession>
    <name>A0A4Q9Q0E1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_330701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0E1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="285"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="387"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="431" mass="46863" checksum="8410E2061532BDD3" modified="2019-07-31" version="1">MVSTHERGGSFPQIPWPSHLQHNRHPTLRDRPLCNMTYNSSDNYAPEVSTATFSDWVGMPGSPYASDQALPSLEDASGSIARFDSDIDELSLDWVNLGNVTCQPDPSIDWDSLLMLNDALPFPPTVLSDMFSSEDRIDEPSSPSSDWTLVQSPGSSMVPDSKLPPAEDTQVDHLSASSPSPFDGLGFDFGCELFGDFLPQQMFSAPPEAGCNAVSLEGDFGWPVYPLMQHSVGAAGAGVTGLATGMGLNVDSAAFSFMAPSLPPCSPPASSPVDEKDEMIIVDEKAAEVNEEKDAPVVKKAARATRMKRRTDSDDGYSSGDSNNSDESAPKRRRPKQDTTKRFICSFEGCHLAFARTHNLKQHFDSVHLGKRSHCCPEAGCERSFSRKHDLARHHQSEHTDLGSPRNAGNARKGKANKKGKTIVKKDSHDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q107</accession>
    <name>A0A4Q9Q107_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q107"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6682" checksum="E03708133F41B9AE" modified="2019-07-31" version="1">MVIKKSGKVKVYGEKGARLDDFRQKHRPPSKLRQVFGDDEEVKKAVSLGSHASLALVCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1L5</accession>
    <name>A0A4Q9Q1L5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_921855</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1L5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1L5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12230">
        <property type="entry name" value="RRM1_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
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        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="232"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="341"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="8"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU60969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="588" mass="65482" checksum="027E28A82BC2FFCC" modified="2019-07-31" version="1">MATAGEETAERFGGERHHASRDYDRDRERRHRDDREHGRERGDRGERDRERDRERYESRRHGERDRDREPRDRDRDRERFGGRGGREDYEEYSRRHRGDDDRRRERRGGGEEEHGGHRRPPRGGGDEERGDRRGRGKHREGLGTPERRSPTPPDAAPLSQRKRKASGWDVHAPGYEQYTAMQAKQTGLFNLPGANRTQIPPILAIPGLPPPMPVSTFGMGTGVNPNLSRQSRRLYIGSITPDINEQNLTDFFNSKMKEMNLGTGAPGNPVLAVQCNYEKNYAFVEFRSAEDATAAMAFDGIIFLNGPLKIRRPKDYGGPDVIAPNMHVPGVVSTNVPDSANKIFVGGLPTYLNEEQVMELLSSFGELKAFNLVRENGNGPSKGFAFFEYVDPSVTDVAIQSLSGMELGDKYLVVQRASVGAKPGQSPIPGMYDLNPEIPKPILPVGDLSESQDRILLMLNMVVPEELQDDQEYADILEDVKEECGKYGEVEDLRIPRPVKKDKAKWGEGGRDSALAQQRADEAAGVGRVYVKYASPRSAANALKALAGRSFAGRSIIATLLSDDANTTPPLNLIFAPQPDAPPPLPQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1W7</accession>
    <name>A0A4Q9Q1W7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Immunomodulatory protein FIP-Fve</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_847551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="P:regulation of immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Fungal immunomodulatory protein Fve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036344">
        <property type="entry name" value="FIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053742">
        <property type="entry name" value="Fungal_ImmunoLectin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015339">
        <property type="entry name" value="Immunomodulatory_FIP-Fve_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09259">
        <property type="entry name" value="Fve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101542">
        <property type="entry name" value="Fungal immunomodulatory protein, FIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12800" checksum="551F4F9B2CE9ACCA" modified="2019-07-31" version="1">MSAHVNNTAITFALVWAEKKLTFDYTPNWVRGHPSSYVDNVVFPKVLTDKKYSYRVLVSGKDLGVRDGYSVQSDGSQKVNFLEYNAGRGIADSNTIQVYAVDPDDGNNYLVAQCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2K8</accession>
    <name>A0A4Q9Q2K8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_921091</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2K8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2K8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039794">
        <property type="entry name" value="Gtb1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630:SF1">
        <property type="entry name" value="GLUCOSIDASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12630">
        <property type="entry name" value="N-LINKED OLIGOSACCHARIDE PROCESSING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043882074" description="Glucosidase 2 subunit beta" evidence="7">
        <location>
            <begin position="16"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="546" mass="61051" checksum="8A181CF6A1A8BE02" modified="2019-07-31" version="1">MHPWLLLLLPLHVLASKDRLLGVSPDLVARYVPTKKGSAETWQCLDGSKTIDWSSVNDDYCDCTDGTDEPGTSACPDSRFYCVNAGHIGSYIPSTRVRDGLCEPECCDGSDEPEGVCPNVCKQVGEEYRERVKAENKLRKTGSKIRSTYLAFAQKEKKRLEEEIASSAQEISAREKEVARLRDLVERTESLSAAALEEKKSSPLYQSLITHHAALKSLQREHKKHLERETALGEILDQLRTGYNPNYQDMAVLEAVRGWEQLAGLPHINDVGKEDENPDELGSDESEAASEEEQLEEGIWSTEQLEHQLDDLLATDYEGLLIEHDKHVGAPASPTSILFNLSAYLPDAVVPQYEALRDQLVSWLELLGLAQSKTDTAADTSKAQKTLGDAEHNLNLARREKEDKERELSRLFDPEWYGPDGEWKKLAGTCIEKESGDYVYEVCLFDEARQKPLKGGQTFSLGKFAEWNNAEGIEKGSPAYYSKQHYTRGAKCWNGPQRSVTLDMSCGLENAVLSVAELEKCEYEFKVTTPALCLPLSASDIKREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3D8</accession>
    <name>A0A4Q9Q3D8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_237054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3D8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3D8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="33974" checksum="0F0439B29C70CAC6" modified="2019-07-31" version="1">MKRPRDMFDTPASSSPSKRRFLSQPAHPSSSPSAPRSTPYTLPRHPLSSPWAFATPHDSPSNPFGLHRALRALALPRPSGFGKHIVLRMQLVSTADPPPHTRTRPSRRHADAPFRVVQVPLNYSFRLLHMLVLFLFASDARLQVTRPRRVFSPPSPSPLTRRPRDKGKASNRADGAHGEGKGGADGKGHLFEVLHGISVCSLAGQRPGQIRAGTGKLYARLSSARERKLFPDPDEDDEEEGCDPVPGAEDADEDGEEGWDWEAEDDFTLSNVWPDGLDLKKGIIYVRPPPLRAVCSVSGPRAPLPPWGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3X0</accession>
    <name>A0A4Q9Q3X0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_812880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3X0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="27785" checksum="1D9A9982F0DBE383" modified="2019-07-31" version="1">MSPTLKMPEPLILAWSLQQNLDQHPEGPDKLIITRLLAMATTTARLACDLAQTPGGKLEIHCVLQDQFSKGTVGVLNAFSAVFDTLENELDHTSTPDGSGNSHLGCGQDTANEASSCDAARSVSPAPTQVVCSHVDSSLVASLTPPLMDALTQPLLSAIQEPLICAIQEPLLAALQKSLLEMLSDRPLTDQLLVSLSRQPHDVTGIPSTGLTPWSRPSRQTSTTSLVPSTSVLSSKALDPVATSSSGFKHKKKRVLPPSWLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q431</accession>
    <name>A0A4Q9Q431_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">GRASP55/65 PDZ-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_812091</name>
        <name evidence="8" type="ORF">BD311DRAFT_668471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143452">
        <property type="protein sequence ID" value="TBU26009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q431"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q431"/>
    <dbReference type="OMA" id="EPEFAMD"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="7">
        <location>
            <begin position="131"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="318"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="414"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR607583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU26009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="456" mass="50539" checksum="A078994DCCE946ED" modified="2019-07-31" version="1">MGAGQSTASQVPPRALHVLRVTPSSPASQTTIEPFFDFVIGYKGDALDSYNTIDASELERIVESHEGRTLNLLVWNSKSLDSRTVSITPSRDWSAPRSDLPDPKEPEAAERKPSLLGLSMRICEPEFALDNVWHVLDVLEGSPAESAGLVPYGDWIIGWSGGVLSAEGDFYDVVEAHIEKPLRVYVYSYDFDTIREVVLIPNRHWGGEGLLGCVFGFGLLHRIPPLPADREPGAIPPELAQNTEEDYEEQQLFVPADLPETAETPEEHEERLQWEQEEWERVQSYGQNYVHDHDPAYQTSSAYHGRAGVQHAHGHGHGQAQEYDTESSGSASEVEVETPHSHHPEYYRDSHAHDHHDRGHDHSHAHADHHRSQHHSSEDHGHNHDRQTVPAPTPVTVVQVQPQTHVAPVPRSAQPRSPSGSLSNPNVLSSPRSSTPTPSRPFGGVAYMNGTSSRHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4G8</accession>
    <name>A0A4Q9Q4G8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_769912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4G8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4G8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026960">
        <property type="entry name" value="RVT-Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13966">
        <property type="entry name" value="zf-RVT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="26516" checksum="7E11678AF3D21FCB" modified="2019-07-31" version="1" fragment="single">QVDPGAKLLEITDSKTVMGGVLEWRQKHEDQGYILQKNAHLARAIVAALRGRRARTAFKWVKGHRGHPLNEMADKLAGEASAKPIPDDLEVEIPPNLVLSGAKLSCMTQKLAYRAIRSMKEGSLQKRRRTEVNLANVAGDIRNTFGVNVPDAAIWKAMWSRHIMFAARYFMWMATHDGYMIGDKWLRPNMSDEQQERAICKRCEIVESMDHVLFRCDSVGQRQVWALFEELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q584</accession>
    <name>A0A4Q9Q584_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_919564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q584"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8663" checksum="2DEFB8724C29E505" modified="2019-07-31" version="1" fragment="single">MLAFELLIELCPVMSFGLHPRKPSPALRRARSTRSSLRATSLLYLCNITIYLPKLVWSLHVKPSCLTHLFLIWQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5H0</accession>
    <name>A0A4Q9Q5H0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_917934</name>
        <name evidence="2" type="ORF">BD311DRAFT_769056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143513">
        <property type="protein sequence ID" value="TBU23175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5H0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5H0"/>
    <dbReference type="OMA" id="SSFWQAR"/>
    <dbReference type="OrthoDB" id="3267892at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU23175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="249" mass="27400" checksum="9213077B55B26FB0" modified="2019-07-31" version="1">MSYPYKRRRTATSVLAGDFDPRPQRDVLTSLLNGVSMPKPTEEELNARRERKREKKEKERREREREKEKTEKKRVKAASKAPEAVAAPIPSTSGTPATSSAIAPLKSASIAAPRATTSSFWQARPQIVIPYLQRSASFSPPPMPSSPPTTPGPSVSSRTSAVSSKRPFTPDDDDELPGRQQSMESDGSMHKRPRKKRPAARKGWKGWVEGSPPPSDKLINLDSVTVLAERKTRSGKSFDAIGAGRDGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q611</accession>
    <name>A0A4Q9Q611_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_918094</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q611"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q611"/>
    <dbReference type="OMA" id="IKFYHVL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="280" mass="30246" checksum="9BC76FB18373AC6C" modified="2019-07-31" version="1">MQRLDQEHHEATTPLTSTSQFIEADDDDLDEEAIPSFTHPGLVPSPHSPGQDKGKARAPEQLASAGSAAVSGNIGTPVNGAGAPQPNRRSVGGVQVETRYTGTDTLDEPIATTIGRDLLSIYTKLIQVLYPPRNNGSRDLLRDWDLWGPLILCLMLGILLSVNAPASQSLSVFTSVVVIIALGSLVVTVQAKLLGGRVSFFQGLCALGYCIAPLNIAALVSTFVHLIYVRVPVALASWAWCVWASVNFLDGTKIEQQRILLAVYPLLLFYFVLAWMIIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6H9</accession>
    <name>A0A4Q9Q6H9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_809938</name>
        <name evidence="2" type="ORF">BD311DRAFT_654528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU63087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6H9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6H9"/>
    <dbReference type="OMA" id="IARQCEH"/>
    <dbReference type="OrthoDB" id="3362246at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU32511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="11880" checksum="7A028ECC8C79A6A1" modified="2019-07-31" version="1">MAQASASGNLMINTLSGPTECVPVQFTWSGGQAPYYLSLIPGGQPSAQAIRQFPIQNGNSYTWTVDLASGTSFTTELRDKTGAVAYSDIQNVQPGPDNRLSPSLHVDASPTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6J6</accession>
    <name>A0A4Q9Q6J6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_917811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
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        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
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        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
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        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
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        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Cyt-b5"/>
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    </dbReference>
    <dbReference type="SMART" id="SM01117">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
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    </dbReference>
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        <property type="entry name" value="CYTOCHROME_B5_2"/>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="518" mass="57611" checksum="DCD6588FE4469B19" modified="2019-07-31" version="1">MSKELKTFTREDVAKHNKPDDLWIIVDAKVYDVTKFQGLHPGGISVFLEADIAGQDATEAFYGLHRHEVLERPQYKRLQIGVIQGEKSVIYSQVPGELSKIPYAEPLGLLKEYHSPYYTESHRKFLHAIRKFNDEVITPDALAREEDGKRPSSSVINQMAENGILAMNMGPGKHLEGRTLLGGLIKPGEFDRFHELILMQELVRHGMRGYRDGQNSGATIGLPPVIHFGHPELRDRIVDEVLSGRKFISLAITEAFAGSDVAGLKTTAKKTPDGKHWIINGTKKWITNGTFSDYFTVGCKTDKGLTVILVERQDGVETKAIKTSYSSTAGTAYITFENIKVPVENTLGPEGGGIFVILSNFNHERWAMCCGASRNMRLIVEECLKWVNQRKAFGKPLHAQPVIRAKLANMIAKSEAAQHWLESITFQMQHMDYKQQAQLLAGPIALLKMYITRSSQEVARDAVQVFGGRGITKTGMGKLIEHYHRTVPFDAVLGGAEDVLGDLGVRQAIKALPKNAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6V5</accession>
    <name>A0A4Q9Q6V5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_811405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="438" mass="48551" checksum="61A155442A2481F9" modified="2019-07-31" version="1">MGGNAFKRLLPHATFPRMHPAVYNALKAQVLPIVQSFYAHATVSPEAPEKADFGDLDIIVAGPRDGLTHEEVRAALRATCSIPQEGNRTSNFAIPVDAFEAVAQAHKAVAAASEPKQDGGARDADAQVTFQVDLNVNGDYAQWERTVFCSSYGDLVFFLGVLAQTAGLSFSIYGLRLAEPIRTYPPQTYYLSYSMDDILSFFGLSMDRWRQGFTTQHDIFAWLATSPFIHVLVARYRSPEYEASTKERLHDRPMRMKFINYLRTQELPACTSGISSTTSLFAVEGNVPEKIDAALRFFGKAEEHAALVYASRAQKRAKELLNGTNLNAWTGVNGKPIRFVMDEVKERLGCLPAAGGGPASPVIAVVEPWQRALSEMEEEELRTLVVSVKEEMEKDGRLEFDWRAAKTARLEKKQQQQQREEVIADPAEEQTTAAVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q742</accession>
    <name>A0A4Q9Q742_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_916953</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q742"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="218" mass="23968" checksum="79D8750F52B9C9B5" modified="2019-07-31" version="1">MSSHASVFDSFAVSFPRGAQPTQCRILHNVMKNWVPNDLGHISHRVPHPRLLSQTLPQDVAHLLNSPPVLSPDQPSTILPYGGLAALDHVCLVSQILCFLGGNADVFVRPFHKFHYGAEFLHLAKELSALPRASCLRLTLLVNRKPIMLTRSEIAMTTHPWTVRVLCMVFHGTPALTTMRRFSFRLGFGIIAVTARSVTISTLQHARDGTGTAPLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q786</accession>
    <name>A0A4Q9Q786_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_944984</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q786"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q786"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="6">
        <location>
            <begin position="31"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="7">
        <location>
            <begin position="543"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="697" mass="78660" checksum="195B2C9C2457DF28" modified="2019-07-31" version="1">MKEFNDPSKDEGYDLQIRAYKAAWTRCLDRNILKALHVPIVNDITEQVRNAYADVLPGLPCPELPVVALAGTSILDYHMPLRHDAQYEDVIYTSQVHLYPAECSSVMNMMKVVVTGFVDRRAVPIDSGKRKPTSLASFDINLLRTWYDAQDAKPRLTVFLHEFEKFDTSVVQDVFYICRQVAPYMHIPHLPLVFVLVMSSPPSPSFLQSAYPRSTLALLRVHHVASPAGLMMVKEVLTKTFFDPDFEPDIMLGPGALEHIIDFASRHTASPDALVTMLQLAHLKHFSSNPLSTLVHDELLGTTLHRAGRTLTSSAGLALLVDALHARLLAASESRPQSQRNGDARPQTADELLAAVSGARTVFLTQARRLRVAFAVARIAECVALGEAPQGVPSGKSAEGRGMRLDSMEMLSSLLRGRGSSQVRYVCMANRKLSATKLRALLEALHSFWYDMESATVRRDEEDARIWIVETLNQLPAESEDPREDDLPVPQDAQTKRLAGSVGDWLQEYIEQRLVRLEDRALWDIWYTGATPFPSELINPAPRPTVVHALLHPHDFIRSYEELTRASGDGEHVFGAPEEQNEPALWELPDTSIAFRRYVEAGRMVNVFDWFESFAVVLESQYKHLKRGKDMQEDENMDAGVDEDADVDMDEEEEEQWKVEVQARFMRALHELDYMGFVRHTGRKPDHVIRTIYDVPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7H0</accession>
    <name>A0A4Q9Q7H0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_581459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7H0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="160" mass="18276" checksum="E6ADF6F9654681CA" modified="2019-07-31" version="1">MTTTIRHRNQLQPILATTHQQYTRITDKQSLNGSTLQNVEVKKSEWQPSHSTSYCYPRISCLLSRCRVHISLFDIMLYFGRSGSQICIIFVESSHRICIMLDSLLGDFLVVYANTSPGSISSGREAGFHISSAQGHGALHCLIYRSCFSCRERRSDFFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7I2</accession>
    <name>A0A4Q9Q7I2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PEHE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_810760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7I2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7I2"/>
    <dbReference type="OMA" id="FEIPEWV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029332">
        <property type="entry name" value="PEHE_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM01300">
        <property type="entry name" value="PEHE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEHE" evidence="2">
        <location>
            <begin position="154"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="631" mass="68811" checksum="0F5A05FFE6930DDC" modified="2019-07-31" version="1">MVGARNGKAAASKSRSGSSQQPTASSSSPAPPPPAAPGGRADGQPPVAGPAESISTRQRRVLPARTRRGGPGVGSCESDLMILETMKRRFESEPLIPATTPFLLTTNSTLISSLASDAGASTSEAAHAQLNTLAYSRYFDRPEVRKAYMEQQLIQTPEFTELPQDAHVGGRFRPRNSEDDTADTSDAAYEKRHRKYETFEKRQRLREKEKLKHEHYKLKERIEQLRAMDSSAFLAIPASEFADTPGCGPEAAAAAASGDAANLHGAAAYHEGERRRKVMLDVAMSLEERYRTLLPPDRRWMEKKGTPKGKGASVEVVEVKHEDDTVEVEEDAGVEELPEKEEVEEDAGEEEMEEEDELIEDEADDDGESEVDPDESDRRKSKQLKLRIKFPPRMLSSKRQSPNPLPTRGGGKQITLSPFFKHTSGGKGHTTSSPLRSASYVPTDKYGRYSEDPEDALPPPPSAKRQRIHDESASAAIKAAKSAQSSKWSKAPKAANGIDKRHTHSAESRTASSAGRPSPTITSASAYSARRSYTSYAGLAGKKDANPCVLMVAALRQSSAPTARKTQRHVTAFGCRVPQEIEEVRDFEIPEWVLVDESASQAGGHHGDREGSYSTHNEHGEDESSIDDSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7R6</accession>
    <name>A0A4Q9Q7R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_808702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7R6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="477"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="762" mass="85179" checksum="DDC1511876AE2FF1" modified="2019-07-31" version="1">MTDAVSTLPAVDDKQSTSDISDEKKGVDGVEISEDAIMAKEVEEFEERLQKDEATEGEYLVQEAYEVAIKVLSTRDDPELPALTFRTFFLGLGFSAFGAVLAQIYYFKPQTLSVSTLFLLVLSYWFGNGLHALLPSHGLFRWINPGPFNIKEHVAIIIMSSTAAVSATAIQVISVQDLYYNRTLNPGLAIFTLIGSQLLGYGYAGLLQDMLVKPTKCFWPTTISTANLFQALHFDNQMTSKRVRVFWTIFVIMFFWEIIPQWIFPLLTGISIFCLANNHSIVFRNIFGGASNNEGMGLLSWCLDWNLIGSGCLFSPIWLQINQDIGICFTYVLMAGVYYGNLWRAKDFPFMSQAIFAADGSQYNQTALLTNGKFDPVKYEQLGPAFFSATNALGLMTSNLSLGATFTHVFFWHWQDIKPFIKSFNPWNKTQQVVHDPHYEKMKVYKQIPRWWYAILLVAAYAIAQATNYGGHSGLPWWALTVILLISATMSLLFATLAATIGFFQFNTSSNGFYQMITAYLVPGDPIANMYGALYGQHPQDQCILMLGDLKLGQYVKLAPRITFSMQVMGTVIGAILNYVMMVTIIDANRAALLSISGTRLWSGQNAQGFNSNGISWGGLGPQMFGIHGVYHMVPICLAIGVFCPLPFIAAWYIWPKARLFENFSTPIILQYSCFLSVGINTSVNPSMAIGIFSQWWVRTRYPRWFTKYNYIVAAALDGGTQVISFMLNFAVFGASGNAHSFPQWWGNDFNLSADRCALPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q840</accession>
    <name>A0A4Q9Q840_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U3 snoRNP-associated protein Rrp5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_808314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q840"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05707">
        <property type="entry name" value="S1_Rrp5_repeat_sc11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05708">
        <property type="entry name" value="S1_Rrp5_repeat_sc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000727">
        <property type="entry name" value="Chromosome 1, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000148">
        <property type="entry name" value="protein RRP5 homolog isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057301">
        <property type="entry name" value="Rrp5_OB_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24685">
        <property type="entry name" value="OB_RRP5_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="134"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="263"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="353"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="448"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="539"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="628"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="716"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="811"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="905"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="994"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1073"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1157"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1074"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1098"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1134"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1160"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1190"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1218"/>
            <end position="1232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1503" mass="165838" checksum="B9B98B6E5F634027" modified="2019-07-31" version="1">MAAGKKRVLDEASGTPKAKKTKTEEQSKKSKDKAEKPTQPVSFLVSDDIDFPRGGGTTLTPLEVKTLRAEAAKEVDKELFAATTEKSVKRKRKSEARGSSNSAAKDGKEKAGIRIEHLNYKTLHLTRLQRVVVGMKILGQVVAVEPLALIVSLPNQLFAHVPITHISTQLTHTLESMEDVEMGNSDDEDEDSSPSGVPDLFEIFRPGQYVRAVVTAVHPPGTTDVSGLGRARDEVQKASRRVELNLVPEKVNEGVVKSDLRTGFTMSAAVKSIEDHGYILDLGMSDVSGFLSFKDAQKGSWGTEKKLHIGQLLDVAVVKMSGNGRTCNVSVDPKTISTASITEVSNVSSIVPGALVQSLVTAVQSDGLVLQVLGYFDGTIDQFHLVPGQPEVHYQVGQKVKARILYDINPSTPPRFALSLADHVVRFTTKSPSADAATTDLRNAYPIGTILEAVKVARVESERGLVVNVGSGIEGFIHISQTSDEHVPTLSASSGAWKLGMVHRARVTGYYPLDGILQLSLRASVLGQKFLQVADVQVGEVIKGTVKKLTDSALFVSISGNVDGVIWPNHYADIALKHPQKRFKPGSSLKCRVLVVDPERKRVALTAKKTLVESTLPTITQFSDAQVGVLTHAVVFKVSDKSLQVELYNNLKATVPAREASETTVPSLSSAFPIGKPVQVRITAVDPETSRITASIRQASPNYKSAIADISGVDIGDIVEGVISDVRKDKAVVALQPTQVTALLSLNNLANRREVSVAQLRSTLKTGDKLQDLVVTSRNPEKGFVLVAMKPKEKEQLVQKNQLSIDTVQPGQLVGGRVLRHARHGALVKITKAISGILHPTDACDDYENGKPFPPVDSVLKAVVISIDKERRQLSLTTRMSRLFPGQDKPIVDREITNISDLKVGETIRGFIKSVAEHGLFVTLGRDIDARVQIRELFDDYVKDWKSRFSANQLVKGRVLSVNIEKKQVELSFRSGDLKRDNQPQLTLSDLSEGQKVDGRVKKVEDYGIFIAIEGSKLSGLCHKSELSDNKDADVTLALRSFREGDKVKAVILSIDQEKRRISFGLKPSYFEERDFEQDESEDEEERESRSSSALGVVEDDDDDDDDDGGVGEDEEEVGAIEAEGDELTAGINGDEDDEADEADDEAGRMDVDLTLDLQKPSGSSSAPSTSGPKESLRLNGGFQWAAPDSSEDVEMGSDQDSDEDVQQEGKKKKKKRKEIEQDLTADMHTRAPESNSDFERLLLGSPNSSYLWVRYIAFQLQISEIDKAREIAKRALKTINFREEQEKLNVWIALLNLENVYGTEESLEATFKDAARHNDSKTIHLRMAEIFEQSDKLEKAEEQYKKTCKKFSQSSKVWSLFGEHYLKRGMLEEARKLLPRSLQSLEKRKHLKTICKFAQLEYKLGDPERGKTIFEGIVDSHPRRWDMWSIYMDMEAGQGDINSLRNLFNRVLTLKMTSHKAKSFFKKWLELERRLGDEEGAHAVKTKAIEWTQRAAGTSGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q853</accession>
    <name>A0A4Q9Q853_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q853"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="22668" checksum="C36F526A1B8CD76F" modified="2019-07-31" version="1">MDKHSRRYLLIMTAPFVQHTTSLFSLDRGWLLVYNKDNCGIWDLSSSAYLALQFQHGGGALLPLCSAFSQKITHVAAIGHEDASGTIRICYWDDRHVVVSDKVSTVVQFRNLDDAMERGALYIELPQQSKSFNSEVNITDPSVVDVWLLNATIELSHDVGGSMDYASARRELLTTLTVSHAASSHSDEFHSVSGAFTTLELVCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q957</accession>
    <name>A0A4Q9Q957_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BD310DRAFT_587447</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q957"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q957"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990604">
        <property type="term" value="C:IRE1-TRAF2-ASK1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
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    <dbReference type="GO" id="GO:0070059">
        <property type="term" value="P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress"/>
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    <dbReference type="GO" id="GO:0036498">
        <property type="term" value="P:IRE1-mediated unfolded protein response"/>
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        <property type="term" value="P:mRNA processing"/>
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        <property type="entry name" value="RNase_Ire1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Putative Serine/threonine-protein kinase/endoribonuclease IRE1"/>
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        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
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        <property type="entry name" value="Serine/threonine-protein kinase/endoribonuclease IRE1"/>
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        <property type="entry name" value="KEN domain"/>
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        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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        <property type="entry name" value="PQQ_b-propeller_rpt"/>
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        <property type="entry name" value="Prot_kinase_dom"/>
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        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
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        <property type="entry name" value="Ser/Thr_kinase_AS"/>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="IRE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuc_2-5A"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
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        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
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    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_ST"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8 20" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020665185" description="non-specific serine/threonine protein kinase" evidence="20">
        <location>
            <begin position="20"/>
            <end position="1179"/>
        </location>
    </feature>
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        <location>
            <begin position="739"/>
            <end position="1042"/>
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    <feature type="domain" description="KEN" evidence="22">
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            <begin position="1045"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
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        </location>
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            <begin position="926"/>
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            <begin position="198"/>
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        </location>
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            <begin position="674"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="19">
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            <begin position="941"/>
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        </location>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
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            <dbReference type="ARBA" id="ARBA00022527"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
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    </evidence>
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        <source>
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        <source>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="TBU63596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1179" mass="129607" checksum="B541E985120921E8" modified="2019-07-31" version="1">MKPLASLSALLVTAGICFAEVLSLRSDPGKDLSTHVNVLRSEHPPSYPGSGDLELLDIVLVASVDGKLHALNRTSGASLWSMASSGTAAPAAFGPLVRTEHPEVDPDLTDDDDASREIYIIEPQTGDIYVMSSSDSPLQRLPFSMAQLVDMSPFSFSGDEDRRVFVGRKETSLLLIELETGRIKATVDPTCPWTPFEEMSESSEEVDLDELEGSKPPRDAGKRTEVYIGRTVDSCLRDIPALSHEPTHYHIAIHTRPEGPSGRTHVQRLTFSAYGPNNQDTALQTLYQRTADNIYIQSLPTGKIMSFKTAATDSTAALPVWSNHFPSPIVTTFDVVRSPKRQQPFVLLQPQPTLQEIFPLADLVTATKHKGLPNLDRAYVGIVEESGSLFAMSPDRFPLVVFGDSSADRNWRSIDPPPGASFDEEADDFPVDVDSAKRVARNRKLREMCRNGATDVRCLTGVRPLGSDSQSRLSRLLDGAPSVLPPPSYQNQNSNRHEVEVREDEPLPDEKDTGNSSIKPPPAWGNRSDPRLEDQPPGKLLRMSGQTQAMSVFALCAIVLLVWMSVKKFLTPGSSTLAQASVPAPSPEVKEDTTKPVAELHALEQPEKVANGHADPVLLPAFEDTTARGDPDEIPTAQQVVFAPATLEPVADPVTDAPDEDTEKEGDGADTPGKRKGIRRGRRGKKKKGVTIVVPRDEVEQAPEPTPTPNSGSDGLKEPASAILLAPSTPPTPVVPTLVVSDTVLGMGSHGTVVYKGSLQGRAVAVKRMLSDFVTLASREVNVLQESDDHPNVIRYYYQEAHANFLYIALELCPASLADVIERPDQFRDIVVAFEPKRALRQITAGLRHLHALKIIHRDIKPQNILISYAKKGAGENAGHRMLISDFGLCRKLEFDQTSFLPTAHGSMAAGTVGWRAPEILRGEVKLDDSGDESQSSRGSVGIGSSGGSSSGTPTGKPTRLTKSVDIFALGCLYYYVLTNGFHPFGDRFEREFNILKNAKNLEGLERFGEEGAEGVDLINKMLSPEAYDRPDTSTCLLHPYFWDPGKRLMFLQDASDRFEIMCRDPKDPNLLALEKGAYDVVGADWHSRLDKLFIENLGKFRKYDGKSVQDLLRALRNKKHHYQDLPDNVKRLLGTMPEGFLAYFTRRFPKLFLHVHGVISNSALRSESMFRTYYELID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9Y2</accession>
    <name>A0A4Q9Q9Y2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_397642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9Y2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9Y2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="249"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="179"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="87"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="347" mass="37017" checksum="BA76274F660C67C7" modified="2019-07-31" version="1">MAPSNLQGLNIVHPVPPSNPYLSDADLLAVPPFPDLNAQLDLWTNLNFQSDEPLHSNRPGENPSCEKESVDGKKRSALDDSGEDDSDRYNDPDEDIQHSGIAETHSHENVVMGTVLPSILPSAANPGQPQLPPFDINSLLAGFGIDPYMAPPAPLPTQAPNAANTIAQLLSLHASTYRPATSQPIPSSVHVVPAQSPPQAPSPASAPTTAKRARTSRSSISSVTTEAMSPQAADSPEDKPSGTPMNAAEDKRRRNTAASARFRLKKKEREAALERKAKELEVRVSELEKECEALRRENGWLKGLVVGVTGAGAVQQQQQLQQQQSVSAAPTPSSDGAGAKRPRDEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAY8</accession>
    <name>A0A4Q9QAY8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T2</fullName>
            <ecNumber evidence="2">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_915946</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RNase T2 family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="2"/>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAY8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF17">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020302124" description="ribonuclease T2" evidence="6">
        <location>
            <begin position="20"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="305" mass="33290" checksum="4217CA1EB23EA671" modified="2019-07-31" version="1">MAATLGLISALLAIQGASASFSLATTFPNISACASEPITYSCENTTVIENTCCSPTPGGLVLQTQFWDTYTGFEKQGQLLPKNSWTIHGLWPDNCDGSYEQYCDLSRQYDPTPSPLVLPDGTPVPPYTGPGVDTFVAEFGRGDLLDFMKKYWVSQGSPNSGFWGHEFSKHATCTSTFDVACYGPDYKKHQDVVDFFDAVVRAFKNYPTFNILAASGILPSNKTTYSLSQLQGALKAQTGAVPYLGCGSNGTVLQEVWYFHHVLGTEQFGHFKTVDSTTKSSCSPTAGIHYFERTPTSERDVRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBJ1</accession>
    <name>A0A4Q9QBJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_943978</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBJ1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBJ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16039">
        <property type="entry name" value="PHD_SPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037869">
        <property type="entry name" value="Spp1/CFP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46174:SF1">
        <property type="entry name" value="CXXC-TYPE ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="946"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="459"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="901"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="482"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="598"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="636"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="809"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="866"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1062" mass="113001" checksum="243069FD80768CE5" modified="2019-07-31" version="1">MSHSPSYGNPQPPFPTPVSSQSQNPPTLASSALFNREPVPSRAAHHRSASFSQPEVPSTVGRSSSAAALNNLLNAEPARPPVASMGTRGNSGGLGGLEALVQAATEERRRLSGEHPTPLEARESARKASLSPVLNRVPSPLPHPPHSPVLHKIPMATSPRDTRVNSLAVISLGHDGEPPMKRRRRTGSFGSGAPAARPPATPIAPPPKDLPSVTPPAPPPLAPVPQVDSSHQQAVRPMTPAGSAPPAPSAKPRTIAQLLSPDPPPKDPSFLSQSMPNPPRPPSPHVTTAPRLQSLLLADSPASQPPAVGAGGNAQAAVVDEWAKQEEEPTETVEEMAETVEESTVAKTEGLMEPKAEEQKMIEPKAEEQEVPQVQEQKEELGAEPSVGERAQPPARSHSPMKSHSPVRVVEDATIPKVEESRATSPAIVREELPALQVPVDPDDVPLPLAPVAQEDTVVSPTEVKMEGSPPPAAVASVADLPTRKVDAIDESPRESVGVEEAEQPVRFPTPMDVEEPLEPSETLAEMDEEAGSIILPLAVTEVPRQPDSEPAQPPTYESQRSKDMREEDPHEWLLEHYADGSPARESRGSSPVAEEPPQTPSEASPPPRPPHDVPKRVSPPPRPRLEPTTRNKKAPSPSRSPTPTALLEQELDDVVPDMLPVSAPSPRSDADTDFGLELELAASATPDAGTDPDMLMGNDLDDELLSLVDDKPHNSHSHSHPHSHSHSHSHSHSRSYRATTAKASHSTPSVAHGEKQPLPAEAVVKPGTSIVPSARAPSSTPALPSERLTMPPPLAPPQSAKQVTPQVSESAENPAEEPNASASVKKKESVVKPAPKMKQSTTVKPKAKPVPKPKVKPMKDKEGTAGSSGRLTPSGSGTVMKGKKATATSATVAAAAKRAVSAAVGPSRSRSASELPMPAEPTPTPKPKAQPEEEEESEEDAVDDKLYCICKTNYDEDKVMIACDRCDEWYHTQCLNMNDLEVDLIDQFVCPLCIKANPNMPLQTTYKQRCMAGLKHPHPSSPSACHKPARGAFSKFCSDECGVAYMQRRIQGARVSSSKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCX1</accession>
    <name>A0A4Q9QCX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_836630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCX1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCX1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="258"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="636" mass="71724" checksum="BD095803B457FDA0" modified="2019-07-31" version="1">MRLLDTETGHFVNNPGTVPYAILSHVWDRRELSYQDALQIQNSSQLTAVVDEVSPSQSPTLVSHTSSAFSIAHSSSILDHPDLTSKVREACRVAREHGYRYIWIDSCCIDKTSSSELSEAINSMHRWYRDASVCYAFLADVPTANRAEIRSPGSPFYQSRWFTRGWTLQELIASRSLVFLSRDWVALGTKVSLVDVVETITGIDQDILRHQKSLDQVSVARRMSWASRRSTTRVEDEAYCLLGIFGINMETLYGEGRHAFFRLQEKILMQIPDQSIFAWGLPFPRRIPPPAPPEVLDLVTLDATLFARAPSDFAHSDAIVSLSHHGFRTKLQRSTLQPPEYSFSSYGLRTELPVVPAHAHYTTPDYVFVILACQHSEGSADDFIAVAFSVHPDASESHTQLVSAGLRWRPRASVGPFITCRLVALSLKDIQARQSPHMRDLLWSVYLPSYDRSTSESALITIDEADVLLAPTIDEGFSSNGYEVECDIVSDAHGNRRRRFSLRKRDIDFFLSGTYESSRHGNHVVVCMVLEECSMLDPYGHPVQKGSMLWIHSTGRTEVTWMGKSNKVENLNAVFRSTTGLSVSLAFSLEVKAGYQCSLVVEEISVRRDQDDEVRPLSSHGEWRRRRRSRQPHGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD31</accession>
    <name>A0A4Q9QD31_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Class II aldolase/adducin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD31"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD31"/>
    <dbReference type="OMA" id="QHALKFY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="43"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="286" mass="31037" checksum="3509A1967366E840" modified="2019-07-31" version="1">MAPVATEAYSDTPKAAALSVAVGKPLQPPQFTSKEQERAWLKFRLAQAFRLFGKFGYDEGVAGHITVRDTIRTDCFWVNPFGKHFSLIQPEDLILVDHHGVVQAAESGPNTLLNKAAFMIHSAIHTARPDVHCAAHSHSVYGRAFSTLGKPLDMITQDSCAFYEDHAVYTQYGGVVLDEEEGQHIVKALGNKKAVILQNHGLLVATNSIEATLHFFVALEKSCQVQLLADAAAAGTGSQTKKVSEAECKLTYNVVGTHTAGWFSGLPHFQVLEAQEGVSFDFGATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDH1</accession>
    <name>A0A4Q9QDH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Amino acid permease ScVBA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_805230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDH1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDH1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="18"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="546" mass="58825" checksum="946680A7B74BAA5A" modified="2019-07-31" version="1">MRGESLSAEHAPEFADHDAHSAALTLFLATTDATIVSTTLPTITSEFNANQAEYTWVSVTYMLTQTAFQPLYGKLSDLIGRTAVLYASIFIFAVGSALCGAAQNITWLILARAVAGVGGGGIVSLVWTITSEIVDVRKQAKWSQALSVTWACSAVAGPLLGGVFCPEKSGPLNWRWAFYMNLPVCAFSFIILWLSLRNIYDGRTSNVSWSHFGRTFDFTGLFFFMGGSSCIVIGFNFATQNGWISPSTLALIVTGVVVLVLGAIYEVRTKRDALFPPIAFKDRTIGIILAVTFLHNFAFNAGTFYLALYFQVGAFLPIAQAVNGLSPFEAGMTMLPYSLGSSLASMPTAWLIGYYQRRSLDTACQKYIICTGLALSSTGFGLMMLLSETSPRSTQIAFPLIAGVGLGMLFHAPYQVFTRALRRQEVASGTSAFFLVRFTGATVGLAVAGAVFLGRLRTTLPAGVDAQVVLESVDILRSRSEWPEILHALSLATKAIWTVCCPCLGVALLISVFTRKISLNETAAREQEKSPGTLAEKPPVMALEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE64</accession>
    <name>A0A4Q9QE64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE64"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14278" checksum="20EF139BD998B2D7" modified="2019-07-31" version="1">MYESQHQVPTPTSGIRPTGTRNSSAAHATNTTHFIGRPFPSYVAAPPPYSAPPPYTRSVSHLQQPTPPWTDVSAHGPTTFVAGSYRPRYQLPQLITQLEHRVAPPPSISPGTADPFPMSPTSPPSRERRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QF54</accession>
    <name>A0A4Q9QF54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="3">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_953631</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="3"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QF54"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000012">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000014">
        <property type="entry name" value="Phosphatidylinositol 4-kinase STT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="1404"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="1683"/>
            <end position="1956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1973" mass="221265" checksum="F4A590D97E577D9D" modified="2019-07-31" version="1">MDHLELNIRQLTLSDLAESIGEVKGEGADADDVVSAIDLITSRVETRQLSKASDEQDNLPDGYSLNGDSHENGEAVAEERVFMSNSRVQCNIGFAELAINMPHSHVKDTVPVLVDILRDVPYIDFDRCLSWDEWAMPDQLVSTTVTALLKIASAHPEYRQVTFDAITNLVKEIVPRFQTEDSFDVLSQYAPAFHGLYRAVISIPFDWSPEEWRSLAEPLNQLFLPDTIERLNKLPIEALSGSGEDVEKITYVQTLVSRYISCGRPLTGYFIVCCVIEAKWTILAQAMSRTYSTKDIDVAPAPQEAAAANIAWQKLLKYHEPGNGFTEESQRVLLRTTMRNVLHIFATLLVLIQEMDSDPADDSYAWETMSESLKLAAVCCAALDELDSGLYERLKTLLSSESPIVDSMVQEAALKSTSILVRCFPDIAAPMANHLRRFVTSPLSIFEFEFASTARTPSSLLAAARCLSLCIDLAPGDDLIMSYMYSLLNYIAATSKDIFETSSIIMNLADVPDLSTLHSVETGLRGLSEDEKRTVGISTISVASRLALENKNEEVTRLTISMLLQRMRAAEPTVEAAIAYNLVDLALIAPQSAFVDIIRAFSSINRSANLDDTRFSNNMVLAAQTRLAKELRGRPELYQLYLTELLTLFADKGVAIQNAAISNHHAKLEEMSEQLASLLLPIDALLSHEDFEIGPDASYNVVTLFRNMWFLCALFGFTAPATRTPTAMEWRQPALARIATRTPPIVLEEAHDTIVSDLEYNTVIRQEYVETVIAKPRALLTKHIPLRASEVRYLLPGQVLFLLAMHDVESMRAAAGCPSSLVTYFVNKGINKNTGLLQCMEAVAEKVIRGAISDLNGQAAKQALPSGLSMELRALLVASTHRILKAREIAARYLNRLITSFPSLMCDPPLVFAILEVLTLLRRATENEFLDEDNPTYTYYSDRADFTLQLTDNYEARNQMLSQLQREASTWFELALSRAPIELHSTLQKYLATVPNSSLMESCELGASIALNWAKAIGPIERKLASLSSMSIFKPDRAKTLANQLASKGYYTGEAAGFKFGRASGLDGLDDPLSFVPKREITLLKKRIADAITSIRDKTNTLTVADLKRLLFRAASTLIFLEEWDHDLAHYLVALPFEAFTQASISAGIECWSWVIAEKPTFEVTLMSEIAAAWDASIKHGKGMFSKSQNYVDPFLQEVQYSPTDKATIDRLTRTAARLITPHGLILQLLFSRLQAARYRRPGLMLLFQRLALSSARAHETMSTHPLAREARFSFLLFGFEVLKSSFLDVFCEHQLRTSLYNAAYSWFAVRPQWSHGSNRVQVDADIKLLSEFLSYLQADSIRGYAPISSLAPTHAPTQAPYYIAALKNLGLPLRLLVENEVFRLTVWGNPVNDTKRGQDHICLVEKTMLDNAWTAAIRRTWNIDPAIAVYMAERFSQPAVQTAVSSLVRSNTRDVLDVPEGLHFLVTESLGASVQRDLRYLLLWAPVPPVLAITFFERRYNNHPQLLQYAHRVLEQHPVDLTFFFVPQVVQALRYDDLGYVARFIFETAKISQLFCHQIIWNMKANCYRDDAGEQEDPMKPTLDRMTDMVVDSLSGEARAFYDREFGFFNEVTSISGKLKPFIKRTKPEKKAKIDEEMAKIVVQVGVYLPSNPDGKVIDIDKKSGRPLQSHAKAPFMATFKVRKERLVVKGSSDNILDADTQGQEETEEYDIWQQAIFKVGDDCRQDVLALQVIAMFKNIFTSVGLTLYVYPYRVTATAPGCGVIDVVPNATSRDEMGRAKVNDLLDFFVAKYGGEDTVEFQKARLNFIQSMAAYSVVCYILQVKDRHNGNIMIDGEGHIVHIDFGFLFDIGPGGVKFEPNSFKLTHEMVVLMGGRTSQGYQLFQQLTVKAFLAIRPHADQLVSTVQLMLDTCLPSFKGEPTIRRLKERFALHLNERQAAEYMMSIVRNAYENVRSTVYDEFQRLQNGIPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K338</accession>
    <name>A0A4V2K338_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_942786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145412">
        <property type="protein sequence ID" value="TBU51072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K338"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="49045" checksum="EC2391F5495D0C95" modified="2019-07-31" version="1">MSRIYFSSSTATLTMHAAALSNVARRRLVHGAAVQTAAASTSAASVSPASALCDAPRAPRVRSHDSHACKANVASSCVTSSSGDISSVSSQHHATRPRRQSRPRAMPTSLPSFGTDKLPHIRALHTSTVVRRPDESNPNSFERRRQELPTSAWSRPPRPSQDADDNTVPSYYVERKKQRDQISQRKEEEGGLMNELNAGILSEGLAAQTKTREEKIPVEVRLPDGTVTHPSGFEPPTAETEFHPVAAKVPTEEHPLLSTVKQPWEEREFVEAGAEPIQVDQAKEAEWIKRMVLEGTGGNGVVSGVSDIGAERPRAAPVGASSTAADRSKITTSAWDTPARSASKDDPDSVVPPFYIERRKQRDSISERKEEEGGLMYELNAGLLSDEVAAHIREREEKIPVEVILEDGTVAHPSGFVPPTAETDFHPVAAKPGDAPKQPWVEILANGNGKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K523</accession>
    <name>A0A4V2K523_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_927209</name>
        <name evidence="11" type="ORF">BD311DRAFT_749422</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K523"/>
    <dbReference type="STRING" id="114155.A0A4V2K523"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000010">
        <property type="entry name" value="Proteasome subunit beta type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU33205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="25859" checksum="FBC178B3DEB09BFC" modified="2019-07-31" version="1">METIDIARLKSGEVNLGTSIMAVQFKDGVVVGADSRTTTGSYIANRVTDKLTHVHDRIYCCRSGSAADTQAIADLVHYYLQLNTQMSGSPPPVHTAATIFQKFCYDNKDALSAGIIVAGWDKEVGPSVYNIPLGGGLFKQPWAIGGSGSTYVYGYCDATYRDGMNRDETVEFVKNTLALAMSRDGSSGGVIRMCVITEDKVERLFVPGDQLPKFWQGREVLGTDHKDASLASAVAMAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5T5</accession>
    <name>A0A4V2K5T5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_913710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5T5"/>
    <dbReference type="STRING" id="114155.A0A4V2K5T5"/>
    <dbReference type="OMA" id="FRVEQNT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="39423" checksum="63CC1906552F9DCE" modified="2019-07-31" version="1">MTATSTLESQPVASTSSQQSLYEASTQYRHWRFSPKQLVDMRYALNSDAVSAIRNAFENDSPGSSASVAFLSAQEEYLLVKLYVGKVSQLCAHFRFPEEVEATAVTYLKRFYLKNTVMDWHPKNVMLTALFLATKTTNHPISLESYASHIPKTAPSDVLDLEFLVAQSLGFDFAVWHPHRSLWGIWLDIQTLPDVSLGDLQTAYEAATKHVRAARLTDAEFIYTPSQIALACFSLASPTLASAWARAKFPSLPHPPVADVLGSIEAMILREGSPPDVEAVREVDRRLRLCKNPEKIVGSNAYNKKLQEKEKKAEEKRIRKAEAARIAMEEGDPFGNELAKKAVEELDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6C2</accession>
    <name>A0A4V2K6C2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/hydrogen exchanger</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_317687</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145290">
        <property type="protein sequence ID" value="TBU51733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6C2"/>
    <dbReference type="STRING" id="114155.A0A4V2K6C2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004709">
        <property type="entry name" value="NaH_exchanger"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00840">
        <property type="entry name" value="b_cpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF187">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01084">
        <property type="entry name" value="NAHEXCHNGR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0915">Sodium</keyword>
    <keyword evidence="8 9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="42"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="531"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="597"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="608"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="643"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="680"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU51733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="699" mass="76883" checksum="8F23C86D531699F1" modified="2019-07-31" version="1">MALHYTPTPAFAAPAASDTAIPEEEEYYSSWSLFLVCGLLILSLCTSYYLQIKRIRAIHETLVAILSGMFVGLVVRLAPGTEIRNMLTFRHTLFFNLLLPPIILNSGYELKQENFFRNFGSILVFAFFGTFVSAIGVGVIVFIWSQLGLESLNLSLIECLVFGSTLSATDPVTILAIFNQYKVDPKLYTVIFGESLLNDAVSIVMYETLSQFHGSDFSVAHLFHGVGIFLLSFGSSMALGVVFGLAMSLLLKHSSLSLYPQIETCLVALSAYTCYFFSNGMSMSGIVSLLFCGITLKHYAYHTMSRRTQRATKYIFSTLAQLSENFIFVYLGLSLFTSPPSSAKVTSYFKPLFIIVTTVAVVFTRYAAVFPLSEMINFFQRHARGQRQEELPHSYQMMLFWAGLRGAVGVALAAGFKGENAQSMRTTVLVVVVLTVVMFGGTTARMLEVLGIRTGVEDDEAGSSDEEEDLRSQYFRRSGRFSRFAEEESYFAGQQVRPQRTGTIYSEPQIYNHQAQNNLLSNSVFSAASSEEYDSDGGEVLPLAPTATTPPGSPPNGRRKSRDGAAVPATSEEGKWFQALDERYLLPLFSNATASRSFHARRMRKSGTSPTPASASASRYGTPGASDDELDDGPEVDLTRMVQAEAGASGQASAHPFPPTPGVMNESRVERGLNSPMMRNPRDSEGQNRERVPSRGSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8R1</accession>
    <name>A0A4V2K8R1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_814106</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8R1"/>
    <dbReference type="STRING" id="114155.A0A4V2K8R1"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00226">
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    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="24252" checksum="3356C1A73AF4252B" modified="2019-07-31" version="1">MASRLNLYDILGVSQNATADDIRKAYKLKALETHPDKLGPGADEKEVAAAEAKFRDVRTAIDVLSDPAKRKAYDNGLNFIRRRIIVNPDEVQARLARERAEWQRQAELRHQERMRVLREEILASQKRYQDTKAQAELRYQEKMKAMEEQLQINRQAEVAAVEVKEKPEGAYTLVDELLSDLRRRSPEWELRRQKVLRVSRASIASAWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8U3</accession>
    <name>A0A4V2K8U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidine deaminase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_921186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4V2K8U3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF203">
        <property type="entry name" value="CMP_DCMP-TYPE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020209212" evidence="1">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="235" mass="25295" checksum="02C6D9368EAEDAA6" modified="2019-07-31" version="1">MMSLSSLGHILLRLAVTLIFGTRSQAFRSSVIANPTLSINNIPFSTRAHWMRVANAALADIKSPCPASAFATVIVNHSAAGLGELVCIGVNSAMTTGNPTMHGEMAAIQNCTSIMTDPDGPFKFTPSRAEAAFTELSLYTNAESCPMCASAIRWSGFREYIYGTSIDSLIEQGWDQIRVPSISIFGQSFDLPTQARLLGGVLTNETDPLFFWRFNPDFPCPTGCARIAGTCEPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9E8</accession>
    <name>A0A4V2K9E8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1017704</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9E8"/>
    <dbReference type="STRING" id="114155.A0A4V2K9E8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="248"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="687"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="700"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="718" mass="79166" checksum="7CC1B6206C1DA556" modified="2019-07-31" version="1">MPKAAPSTSTATRSSGAPFQSAQVLRRNQACHQCRRRKLVTLFVYSDAKRPCSTCVRSHAYSVAHAPPGTELPPHPECTFDEVSESTIPDSEDSPKNRFERLENKINELEALLREKDQSSPSDDSSPSRTRSAASSYESSSLIMSYPDSLNIDPTLNGAVIDMTGFSTTPGLDDLAGVSAFVGTPFQMSFDDNISQNNMAQSQEKTYPRPEDYGEMLNPSWPKGLPNHSTLRYLVEAFFTNTPLADRMFHSRTFLASLELPSTHSKFPLPAILHAMCALGSMYTASAAPSSHGLSTACSQTVSFAELQIQAARLGLEYSLRTTSNLFGALQAQVLVALWYWYNARWSEACVAFSISLRLAVPCGLNVCPPFESISSSNMARSSIIPASSNPLEDETRRNTFWIAYMMERHFGAINNFAMFLDDEDVCQMLPVRADQFEQGILVPSDNRQWSHEPGIVHEHMDEQIDSFGLHVKASMILSKVKLFNSRYKMRRHRGDPALEPDPAGLPGMPRPDLIQSTPAFVEIDNSIKSFLASLPSHLKDPFANGTIDVSLLTAISSAHFATIILHEGHANIGRPTCISSCRVLTASRAILNLLYRAYSTSHNLALTGVFPMVCWFAAGRVLVRFLRSAIEAKSDEHITALQAEVDFISRGVISSIGESVPHARQYGKMLNDYLIQTCGKEYAKPASVCPPPRPSGESHQSEGHGFQEDDMEAPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9I4</accession>
    <name>A0A4V2K9I4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_807715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS52 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9I4"/>
    <dbReference type="STRING" id="114155.A0A4V2K9I4"/>
    <dbReference type="OMA" id="PIRTSMT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048361">
        <property type="entry name" value="Vps52_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048319">
        <property type="entry name" value="Vps52_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20655">
        <property type="entry name" value="Vps52_C"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Vps52_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps52 coiled-coil" evidence="7">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="251"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Vps52 C-terminal" evidence="8">
        <location>
            <begin position="370"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="577" mass="64863" checksum="CCC213F7D4BB7C35" modified="2019-07-31" version="1">MCPEDQLRAREFVELHDQVQTSVNLLDSLEGFLSTFQKDLSAVSGQISNLQDRSKDIDNRLKGRRRIEKPLSNLISDLCIPPALATLILDTRVDDDWIPAIVEFERRLETLKLRVRVKAARDLSEVAEGLRIVAATKLRTFFLAMLEPIRTSMTTNLQMLQSSVWMKYRPLFVFLQRHASNVASEVQRAYVSSVRTFYETGFRRYLRGLGWVKARTVEKSESIISGAGETSQGLEFDANRLSYARVDGPSVTMAYMTEDKNYKEPLEALVRSALMVLMDNATAEYAFITSFFANEPRPPPQSRDQTGSAAMSPPILSPTRGEFDELRSGPGSEIGSDSVSPRMRPVNITSVIQAAANQEQTAKEEQAALNALWKQVIDPILDYCSTFVAGAIEPPPPVIPLLTIIRLTEDIVAEVQRRGCGPLETYIFTLRLKMWPVFQKLMAEHVDALKKFAEGASAGYFRRSGTTDAAVSSVCRRYVTIFNSFVALTDQPEETMIFSNLLRLRQELSKLITTHTDKLGDQVAKASAQSTFYEQILQGLSNGPHPASHPKAQSELAYWRQRDEESRRRVVSTHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9R5</accession>
    <name>A0A4V2K9R5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_292215</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9R5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19973" checksum="8F00AF5BB4FE1AF7" modified="2019-07-31" version="1">MCRNSDRPKMERIVLPGTSSVDTVTISVTFQMSALSSVIPIRLCWACLRPFYVRDCMRDTRNWDNITITSPMVLDAVRSPSTYIRPEMLQVSHPHQYRCAPRESRSVVRSATSREMPSPGGMRATAGQRSLFIRGAAPEHRGCLSYDFRQARSRSGARELEEARHGARTGERMRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MW56</accession>
    <name>A0A4V6MW56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_832758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145262">
        <property type="protein sequence ID" value="TBU52198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MW56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26902" checksum="ABA5AB7C1C7FE72D" modified="2019-07-31" version="1">MDPIHFVRGLVANGPPYPDDAPRAVVDFLTAMDAALPMRENAPYNDVSVVPSDYRVKYFLDAFEIFPSPPPIPDAPPRKLLTYSLLRLALFCARGASLLHRAEDENTNILDDESASALFYELQDRIEEVCDRLSNASTLGDLFENLCVSIARPPRRPPPIPMSDSVITASPKTRKSKTKTTRKARKPAPVGPLPTFRSAGWGRTESSAAASPTQKRPSRPPAPISKSPWDDFSTSSSGFSLSRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWZ3</accession>
    <name>A0A4V6MWZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_805201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the translin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWZ3"/>
    <dbReference type="STRING" id="114155.A0A4V6MWZ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14820">
        <property type="entry name" value="TRAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.190">
        <property type="entry name" value="Translin, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.200">
        <property type="entry name" value="Translin, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016069">
        <property type="entry name" value="Translin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002848">
        <property type="entry name" value="Translin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016068">
        <property type="entry name" value="Translin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036081">
        <property type="entry name" value="Translin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10741">
        <property type="entry name" value="TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01997">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74784">
        <property type="entry name" value="Translin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="274" mass="31336" checksum="124FE45CC84016D1" modified="2019-07-31" version="1">MTLPPTLNSRDTILAVFDHFREELDDHNDRRERLIKSSRDVTNLSKKVIFLLHRTMTEDVGEADDRTLGSRAASRARGKLKEIQSLFAGMRPELSGDRYARYQRNVSPGLQEYIEALSFAHYLEHRALISYEEVQRSLCDDDGTPYFPLSLEDYLLGLSDLTGELMRFAIASISRRGGRQKANDVCHFVRDYFEGLTPYFRDLRKKQAVTGQSLEKIEDAAYAVAVRTSEFDLPSEMLDDLVAQMVSRTADRSGFGDESGRRKPRETDYMDADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MGI8</accession>
    <name>A0A4Q9MGI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_833526</name>
        <name evidence="1" type="ORF">BD311DRAFT_764885</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143464">
        <property type="protein sequence ID" value="TBU25242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145283">
        <property type="protein sequence ID" value="TBU51820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MGI8"/>
    <dbReference type="STRING" id="114155.A0A4Q9MGI8"/>
    <dbReference type="OMA" id="WMNSAAD"/>
    <dbReference type="OrthoDB" id="3141838at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU25242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="248" mass="27542" checksum="9D5575CA6555ACBD" modified="2019-07-31" version="1">MSRRSSSSTLPEHNDVMLTPDILIGALHDLSTRLRQYFPSTVRLVVHGGAIMVLHPMLACRGGTRDVDFIKRSFEAEWIALGVTDAGARLATCIKATARKFHLGADWMNSAADVALPMAFDAYGKTYDPIYTDAVSPANMSISTLFTSPGLVIIGVSWAWSIALKLVRYDKHDPQDIASILRLGRNQRNVKWTRSLLESWLVQECGAMGYAAYAPWQMEALRKKMRNAIELAYHPPPAVPQLGPVRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MJ28</accession>
    <name>A0A4Q9MJ28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_935147</name>
        <name evidence="15" type="ORF">BD311DRAFT_665142</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="ML143431">
        <property type="protein sequence ID" value="TBU27540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MJ28"/>
    <dbReference type="STRING" id="114155.A0A4Q9MJ28"/>
    <dbReference type="OMA" id="LTHFTCV"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="11"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="52"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU27540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU54717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="16819" checksum="6A5303347B44BE33" modified="2019-07-31" version="1">MSVNTFSIHPDDRSRLIKATIEAKEFAYARYSNFRVGAALLTTTGDIIKGANIENASYGGTICAERTAFVKAVSEGNRSFTALAVVSDVASAISPCGMCRQVIREFCAQSMPILLIPADYDKRVAEGDVTGGVKETSIAELLPDSFGPEHLDLPRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MSU2</accession>
    <name>A0A4Q9MSU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_906845</name>
        <name evidence="2" type="ORF">BD311DRAFT_738123</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143406">
        <property type="protein sequence ID" value="TBU30367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MSU2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040683951" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13297" checksum="27BC55501DDA5F4B" modified="2019-07-31" version="1">MRLSVFAVIAAAFAAVGAVPTGPEVVTPGSGDIIGLSFDFKYVNPSRTESQYESILIATLNNATTENGFDPQPEFSKTDPTTATARLNVDSTKVAEGDYNFTVTEYGLPGVIYSTSFPVSLNYDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MWI8</accession>
    <name>A0A4Q9MWI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_925506</name>
        <name evidence="15" type="ORF">BD311DRAFT_751598</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143397">
        <property type="protein sequence ID" value="TBU31787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MWI8"/>
    <dbReference type="STRING" id="114155.A0A4Q9MWI8"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="14">
        <location>
            <begin position="39"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="12">
        <location>
            <begin position="236"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="13">
        <location>
            <begin position="439"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="505"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="507"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU31787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU59212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="611" mass="67404" checksum="B322B236CC93E26B" modified="2019-07-31" version="1">MTTQAVASLQAEVNKLRHELQTLKVGGESSSLAGETLYVGQYLVERLAQLGVTKMFGVPGDFNLGFLDFVEDHPKIDWVGNCNELNAAYAADGYARVHDGKLGVLTTTFGVGELSAMNGIAGAFSEHVPVLHIVGVPSTGQQKAKPMLHHTLGDGRFDAYYKVAQEITISQATLTSKENAAAEIDRVITDCLVLARPVYLMLPTDLAYERIPSARLKTPLNTQPPENDPDVENFVLDEIVKLVDEAQNDVIILVDACAIRHGVKNEVKELYERTGYPVYAAPMGKTAVDESYERYGGIYVGSISHDAIKEKVENAKLILSIGALKSDFNTGNFTYHIPVTRTVEFHSDHTRVQFAGFPGIGMKRLLPKLTQRLQPFKEGAVGLEVGKYIPEIPKEDTDEITQTYLWPRVGKFFKSNDVIVAETGTSSFGILDIPLPAGATFLSQILWGSIGWTVGSTLGAAYAAQDRGLGRTILFIGDGSLQLTVQELSVMIHRGLKPIIFVLNNSGYTIERYLHGMDRKYNDINNWRWTKLLETFGGEEGKTVKSYQVRTKQELSDLLDDQTFDSAEVIQLVEMIMPQKDAPRALKVQAELSGKSNRYAAEILTETVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N021</accession>
    <name>A0A4Q9N021_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_953952</name>
        <name evidence="2" type="ORF">BD311DRAFT_687433</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N021"/>
    <dbReference type="OMA" id="DEKCHRI"/>
    <dbReference type="OrthoDB" id="2756306at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU32442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="261" mass="29422" checksum="6E41BDD0D7A00C64" modified="2019-07-31" version="1">MSPELVSKPGHLCRRVVNIDDGSESLAHQMGLTNSRQDLVMYFDIVNTAGTLCDKYLPPDPGIMSRYTAVKRKIIKKLLEKYPILGHYENNWPLKVMIQYHRQLRRNGSKTGIICSPNRILKATTVAARRKSDEKCHRILREDDTPGIPHQDGPSRDATPSIGRSDDVREPSPSLTAVDNPAESSAIPVPILDFLSALAQDLSFLLAVFISHGVGDDTSLQSMLQMNNWRSWMYTWVREGVLTELQFQMIVDGLEKLLRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N8U7</accession>
    <name>A0A4Q9N8U7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_942900</name>
        <name evidence="5" type="ORF">BD311DRAFT_812885</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N8U7"/>
    <dbReference type="STRING" id="114155.A0A4Q9N8U7"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase dynein-related AAA" evidence="4">
        <location>
            <begin position="186"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU35426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="423" mass="47336" checksum="42E1D3C95B35BEDC" modified="2019-07-31" version="1">MDMMMPIKPMILSADLFPQNHLHPVHAIATPRPTLLFALASDNVEEVRRVLESGEANINDDAAPQSALAFTIANDQLKNKMQMVKLLLAYGADTSVLRDAEEDEREERSSRRGSGRLSRLLQNVDPATRYYIERADSPQTRRASALIHRSYFRPLTRVRYELIGQDRVLEQLFRVLSMPSMAPIVVLLCGPSGHGKSLLARKFGSLLGVPTHTVNMTTLRDTNDIWKSHSIAPHEEPSDKSLKDFLIENEGKRCVVVLDASEIEKTQDEKILSSLLMPWEYGRCSFEAGYRHVDVSKVIWLGTSNIGHNLVFEHQDQRPSPGTQLSREEYVDLMGLLRPRVSERLGPSLLSRVTAVLPFVAFTTDEKMALAAEALHSLVGETVTDMPPATRDLIVRTSLNSYIPSEGARSLYRAVSTLLLDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NC83</accession>
    <name>A0A4Q9NC83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_939819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145243">
        <property type="protein sequence ID" value="TBU52614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NC83"/>
    <dbReference type="STRING" id="114155.A0A4Q9NC83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043758642" evidence="3">
        <location>
            <begin position="23"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="367" mass="40420" checksum="6359E0B32109E928" modified="2019-07-31" version="1">MLPSLLLPSTLLFSLAAVQVRAGDVPWLQPCDPAHQKLQEGTFQFQTDCDAMTFCASNSTCALRGCRNDDFPFGYLSNVTVPDKCPKGQFCPDEQDQCQNVLPVGSACQFNRDDECEGPPNFKDLADTTGFGLNVNGSVCLNNICMWANVTVGLPCIVQNTAYTAYGPDGEFVDIVSRGNCKVGLYCDSQQLVCVQTKAIGEQCDADKECSTYNCLANGTCGVTTDTPVQVKKWVYVVVAVCILGGMVGTLVALYFFHKKDRDAEREKRLQYWREQNAFRQNILQMQETARHSLMAYTPGGGSPRGSTLYSREGGMQSEDSGAPMLQQTTKSSGLRYYVSDDNSQLDDRSDEDLMMGQRSHQDVGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCS3</accession>
    <name>A0A4Q9NCS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_386818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCS3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NCS3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058329">
        <property type="entry name" value="Arp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26053">
        <property type="entry name" value="DUF8016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Scytalone dehydratase-like protein Arp1 N-terminal" evidence="2">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="214"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="656" mass="70363" checksum="E717DF6CC6DBBEAD" modified="2019-07-31" version="1">MQLSGFSAVIVSAALRLTSAAQVSIQDTGRTLVLNNISYFLPPVSVSALQDTVALPAGSPGSLIPFSVITTSNPGFDEAALQDTIATWSIMDDVWNNAFLTGVFVDFNGTERSPSVSLSAAQKKLGIDVVLLSPKYRGGVALTKTLPSGPYFLESSTGNVFEALRLYNDEQQSFLYGTIPDAKGGFQVLSARVPGAATETIGVPSRLYFTPTVEKPFAGKRLAVKDIYDVQGLHTGCGNRAFWQFYPPKSATAPAVQRLLDGGMILIGKTKTSQFANGELATDDWVDLHAPYNPRGDGYQDGSSSSTGSGTAIAAYAWLDFTIGSDTGGSMRGPAGANGVFGNRPSHGAVSLDNVMPLSPELDTGGVFSRDAKLWAEVGHWWYQNSTSFSKFPKKILFPTDFWGTSFLQNPPAGNSVSGTFNTFITKLEKFLETNRTEISFSLTWNETKPATVSGTVQQLLTTTYADLISLDQIALVADPFINDFGAANGGRAPFIDPAPLARWNYGRALPAGRKEQAAANRTIFRDWVASEVLKSDPTTCSDSILLYPQSRGGTEYRNAYINPPSAPLGFSSGRLAVHAELPDMVVPIGEAPYNSTVTGKTEFLPVTISFVAAKGCDLMLFNLFAALQDAGIIRPVVTGSRMFSWQDLSEIAPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDY8</accession>
    <name>A0A4Q9NDY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_826843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDY8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="248" mass="27654" checksum="6E9F8B462DD03ED9" modified="2019-07-31" version="1">MDIDSAHPSPLLPRSLEVMHHPFTAIDMQFTDECSLVVAQSHIAGFWVLADVEEIDVDWQAWTSVIPDRLELANITTLRIHIQGTHNFWHTIFGPMIQLKELAVSLDKASLAPTARPPVVILRSVLSQEPLLCPALHTLNIEWPNAIKSDDLCVSDLTDMLVTRTRLGCPIHTLAVRAIAVIVDIGGQRVWGFGPMLAPLAALVQAFSSVSRLDEHVCTFEPSRIWSVEGAEEYWELDQCSRPHYSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEJ8</accession>
    <name>A0A4Q9NEJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_830729</name>
        <name evidence="6" type="ORF">BD311DRAFT_673534</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143500">
        <property type="protein sequence ID" value="TBU23602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145224">
        <property type="protein sequence ID" value="TBU53135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEJ8"/>
    <dbReference type="OMA" id="LWNSQHH"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000036">
        <property type="entry name" value="NADP-dependent oxidoreductase domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU23602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="325" mass="36639" checksum="D9E5C956D81A2A99" modified="2019-07-31" version="1">MSHGKYLTLSTGQKIPQIGLGTWLSKPNEVENAVEAAIRAGYRHIDAAIIYGNQDEVGRALKKVIPSVVKREELFITSKLWNTSHKPELVEKELDETLKQLQLDYLDLYLVHWPVAFPYGGALEPLDPNKPDWVVLDLETSLVDTWKAMIKLLDTGKVKAIGVSNFSIHHIQGIVDATGVWPAVNQIEAHPLLLQDDLVKYAKEHNIHLTAYSPLGNNLAGHKKLTEYPEVLELAQKYNATPAQVLIAWGVKRGYSVIPKSITPERIVSNFQQIELSDEDYEKLSELGRKSPKRFNVKTTYPPFWDINIFGDELEQSTTNQIKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHK8</accession>
    <name>A0A4Q9NHK8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_953143</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145294">
        <property type="protein sequence ID" value="TBU51678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHK8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="38706" checksum="5DADC8750AB6E6DF" modified="2019-07-31" version="1">MPLPVLALCLSLKLNVNVFGLYDAAVSSRLQGVHLLRTHSSPVDAFEGMMASPVLRPRFKALSLGYHNEHMSRERTFTLDHRQYPALEHLCLEGVPIRLPDPTLWQPISSLTRLVIKFRTVKRSPHVNSAGVPVPLPESVPVRRVILHDTNLSLFPPHHHAVALQVIHDHIPVAGFRYGHLLRDRLQGRPTHLQVAVSPDTTANSGGFEFSVTVATPGNAVRGGSNVTLLGKSHHDQPDIWLNHLLSDEVADLSTVREASPFISSATTALRRLPALETVVLVTIDHPSNGPGNARDNIKVGFRRMLEQLAPGAYRYLEHLIVQLSPGFEIEDAETVVGELKAYFLGIDLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHW1</accession>
    <name>A0A4Q9NHW1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alpha-galactosidase</fullName>
            <ecNumber evidence="9">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_920352</name>
        <name evidence="12" type="ORF">BD311DRAFT_702041</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="9"/>
    <dbReference type="EMBL" id="ML143478">
        <property type="protein sequence ID" value="TBU24531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHW1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHW1"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000197">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000111">
        <property type="entry name" value="Glyco_hydro_27/36_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF61">
        <property type="entry name" value="ALPHA-GALACTOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00512">
        <property type="entry name" value="ALPHA_GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040684016" description="Alpha-galactosidase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha galactosidase C-terminal" evidence="11">
        <location>
            <begin position="357"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU24531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU61602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="432" mass="46447" checksum="E898BA3593352C8D" modified="2019-07-31" version="1">MAVSLHRLFSYVLGALVVTAAAHKSAPSVTSTAASSTLTGIAATAPTIGPSHQVGRLPALGWNSWNAYSCNINETKILDAANLFISLGLADAGYEYVNIDDCWPLETRDASTGRIVPDPSKFPSGISGVADQVHALGLKLGIYSDAGTNTCAGFPGSLGNETVDAEAFAEWGVDYLKYDNCNVPSNWTDAATPPDNDWYNSNSAIRYRQMTAALNQTGKPVHFSLCIWGDANVWEWGDRVGHSWRMTGDVSASWSSISSIIAANAQHLDSVDFFSHNDMDMMEIGNGDLTLEEQRTHFAAWAFLKSPILLGTDLNNLNSTQLDIIKNAQLLAFHQDPIVGTPATPFNATASAPSTSPPEFYAGKSSKGTHVFIINTNTTATKTFEFGNVPGLGFGRFRVQDMWTGKNLGTFANKFSITVDTHDTAALLIHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NK22</accession>
    <name>A0A4Q9NK22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UROD/MetE-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941288</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145276">
        <property type="protein sequence ID" value="TBU51930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NK22"/>
    <dbReference type="STRING" id="114155.A0A4Q9NK22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="398" mass="45502" checksum="C02C03A490288F1A" modified="2019-07-31" version="1">MSAGLKLLPPFRADHIGSLKRPAKLLQKRKELDEGKATIEELRLVEDEAIREIVQLQREVGIKSITDGEFRRHMFFDGVFDNLDGMKFIKPVPPEMFMDYVPDIAAFKVHNFKGADSYICVSKLKRTKQFYVPQYEALKALTAPEEHKNLKITMAAPEWFHLRHGEYAYPKDVYKNDEEYFDDIALAYRQEIAELYAAGCRNIQFDDPLLAYFCAESMIRGMEERGVDHVALLDTYIATYNKLLAEKPADMTAGLHLCRGNFKNGMHFSEGGYDRIAIKLFREINVDCYYLEYDTPRAGTFEPLRWLPPNKSVVLGLITSKFPQLEDQEDLIKRVHNAANIIADGEEKRSFEEALNQICISPQCGFASHAEGNLVDEAGMRAKLSLVVQTAKKLWKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKG8</accession>
    <name>A0A4Q9NKG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_933119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7823" checksum="332B7280A2FF91AE" modified="2019-07-31" version="1">MKSTFPTYSSNRRANINIRVTWAGRPTHLFMGPDTCHFTLSPILAPLSPAHRSSRVSPATARPNSSGPDSGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLE3</accession>
    <name>A0A4Q9NLE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_198714</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLE3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7325" checksum="3DDF759F5F8BC876" modified="2019-07-31" version="1">MSYAKEPQSNGIGRTLKLKGRIGVGSRLRQTKKWNLESLGKPKKAQKSCRILMQSMNEGLLPLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NP53</accession>
    <name>A0A4Q9NP53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_976641</name>
        <name evidence="4" type="ORF">BD311DRAFT_802588</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NP53"/>
    <dbReference type="OrthoDB" id="2648403at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="33"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="637"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU34219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="676" mass="76918" checksum="029640A218C05117" modified="2019-07-31" version="1">MPPLAAHRVAPDRNELRLELNREYPDERKKIVWERYDKDVKAYYDALVKRWLKEMDNILVFAGLLAAVLTPFNVESYKSLQPEPTDALLAVLQQISTQLDSASVKTGSIDTTAPSRTLAETQLTFVASRSAISLNVLWFASLICSLSSASMALIVKQWLHDLSMGLCGDSRAVARRRQYRYNSLMKWRVIVFVIIPPLLLQIALILFLSGLLVLLWDLQRTVWAVSAALVGSLFLFLAVVAILPIVWRDCSYRSPQARILYLLVRWTLRLIRPTLTWLLHLLLFWAGELLPAGRRTVLQPYYQILTSKRWLLPSWRRSKEAPPFANTGTLDRTTAVMAFTTTYDDAHLEDLPDVLSDIPTAELAPAFDQIATALEVRLRRMNDPDEPPVTGLDVPLTAAIRQCLLAEQDTGTDHRVIADTCVSLLRRVRITDGTDRNKFMDIIALIFDFRFGDQRPTSLAFQHLLALLEIGSQGDQRLSYRSLLYAMSALDVAIDPKRSAYWHKRSDSRYQIFVIHQLEVVQGVVRCTLEALSSETSLSLSEARGVCDTGKRILSKFQDNWGNLDWNGMLKPKRRGHELKLRSSLTWVISEKLLGWSPFRDLCADPRSCVILSDQFFVTLKNALSSAKAKRLKDPNLQDMEEESKLEKRATDSLERLERDLASHRRSVSPFVHYGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSC9</accession>
    <name>A0A4Q9NSC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_969454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSC9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="36772" checksum="577E4D2D6BD98660" modified="2019-07-31" version="1">MDSDYKPLIVSDVQRAICALNGVVVLLQDNTRPTTGSELIEKNYPQATLGQFLAFSQMVVESLGSAHATVSRWLMETGERLMRNLGEGRDVEDALKKTSFELGEADYLAGATEERIQILNAHIVNLNAEFHQAEHELDRAESRLERKTRTRDLARLGGALIIALIPRASETSFVDVLAIVDREALQAPVDEQKEIVSRLESQLRTARDQLQVQTQKLENERAEGLRLCSRIDALRQKAKDLAADARALETARASLAELSVRIHECLRSVNGALNSATSISIMRSMGDVVSGLRGVVVSLGQEAMFSGPLAQLNDAAFAALDRRVSTVRYHRVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTK4</accession>
    <name>A0A4Q9NTK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_97343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the terpene synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.-" evidence="6"/>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTK4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010333">
        <property type="term" value="F:terpene synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034686">
        <property type="entry name" value="Terpene_cyclase-like_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201:SF4">
        <property type="entry name" value="BETA-PINACENE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35201">
        <property type="entry name" value="TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19086">
        <property type="entry name" value="Terpene_syn_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="300" mass="34039" checksum="4348685CD35CC868" modified="2019-07-31" version="1">MGSIRIPNFPAFCSPHFELRCNAHCHPVTLSSEKWALANPLFLDADEESRLTGARLGLLAALCFPTCDAGQLLSITKFLIILVHWTDKPRSLYADEEIFDPVWTRAFRPTTRRDWQKRFQRHLAAFRLGQAITARNAAESVVPDLESYIAIRRDACGVKMLLDLIIYAGGLVIPPQIYDHPILRRLRQDAGNIIAWATDIAAYARHPRTSNIVTVVMTERKFAPQGAVHFAGNLIKETFCTFLQNESQLPMFGDWDDDVRAYVRGLRDCVVGSLHWLYETDRFFGEVGEDVRTSGWVFVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW35</accession>
    <name>A0A4Q9NW35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_823582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW35"/>
    <dbReference type="STRING" id="114155.A0A4Q9NW35"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU56497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="367" mass="41608" checksum="1FB17E817E282328" modified="2019-07-31" version="1">MANLAVFVVVCSIAYMIWRFTRNFFVGTTPLDNIPGPAPASLLLGNMQRFFTHDNDAFLNHLIETYGPVSKLTAALGIKTLHVYDLKALHSIHVKDQDNYWRGKITNETGDLTIGPGLLSAYGEKHKKQRKILNPAFSTPHMRELTPLFFDIVGKNRSRETGQGWSEGYRDTWLDEARFHGARWTGILGYSFDPLVSDSEDAYAKAFKDLIPATTEARNWAVIIPFLGYLGPAWFRRRVLDVLPIKSVQRVKNYGPLIPYDELSQLPYLDAVCRETLRLYPTAYLSVREARMDTVLPFSEPVCGVDGTLLNEILVPKGTILWSYIRACNTNKALWGEDALEWKPERWLQPLPQAVEDARVPGTYSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW41</accession>
    <name>A0A4Q9NW41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_807980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW41"/>
    <dbReference type="STRING" id="114155.A0A4Q9NW41"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="16"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="583" mass="64765" checksum="87F9BBBF297E416D" modified="2019-07-31" version="1">MRADDRKWLEGFIDENLVEGTARPPPRHPPAPLQQLPTPPSTTTTEILSTLSSASTLASLNGNQRDEEYSDSDDEGNATLWAKPPTKKDKPAELLQSTAAQKTRPPLTPLSIESSPNSAPNGLPPVHSYDYGRSSNQPLPFLASPPPTSREPRTPRRQGAQKKHKDRISKFDNNFDVTWAPRPPPEVMYERLEEYFPEHDLDKPVIEAASGGTSPTATELPAVPMPPQQRFRHKKSIRVVAAEHKRQLDRTSRGDDSTVAPMSRKRHTKMWGGKLEELTTEQGKGPSSSTADPSPGGAKPIFRWVRGELIGKGTYGRVYLALNATTGEMIAVKQVEIPRTASDREDSRQVTVVEALKLESETLKDLDHPNIVSYLGFEETPTFLSIFLEYVPGGSIASCLRKHGRFDEEVTKSFTGQILSGLEYLHSRNILHRDLKADNILVETTGVCKISDFGISRRTDDINMAAAYTSMQGTVFWMAPEVVNSKGKGYNSKIDIWSVGCVVFEMWTGQRPWSGQEAMAVLLHLYQTKQAPPVPDGVTLSTLADDFRLKCFAADPDLRPTAAELRRHPYLELMPGWTFNGFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZB4</accession>
    <name>A0A4Q9NZB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP-dependent DNA helicase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_806197</name>
        <name evidence="1" type="ORF">BD311DRAFT_660987</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143412">
        <property type="protein sequence ID" value="TBU29607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZB4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZB4"/>
    <dbReference type="OMA" id="IRAYQDN"/>
    <dbReference type="OrthoDB" id="3353471at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18809">
        <property type="entry name" value="SF1_C_RecD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274">
        <property type="entry name" value="DNA HELICASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23274:SF51">
        <property type="entry name" value="OS03G0423850 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU29607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15164" checksum="CBFA2E11F986319F" modified="2019-07-31" version="1" fragment="single">LCNFAPDRGLVKNTRVVVVHIGKKIVTVRILRGVGGVGSMDSEDVLISRIPFSAVLQSGHTLVRRQFPLAPAYATTFNSCQGLTLDVVGVDLTRPVFSHGQLYTALSRIRHRSHARVRLHPWQRTTKNVTYHEVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4K4</accession>
    <name>A0A4Q9P4K4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_849296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4K4"/>
    <dbReference type="STRING" id="114155.A0A4Q9P4K4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="3">
        <location>
            <begin position="84"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="639"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="736"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="760"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="901"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="924"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="961"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1029"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1086" mass="116033" checksum="3F8A4E45D59410CF" modified="2019-07-31" version="1">MGHAQKPSVDSEMHELNAEADFLEQKITVAPVGASGEDARVQPQQSDPDAQAMVIESLRSQVQDLFSQVSQLNNKLVRSYDRVSDLEDELHVTSQNLRQATIKVGQLELERTQHLSALSTGLLVEKSHVTSELTRLMEKATEEAARRGQAESARAEIEKELDDLSAGLFDQANRMVAEARIAEAKSARKVEETEAALRSAEEIVGALQAQMQTLEADKEQADRRVEEMRLRMGKGKWVEHGVNHGHTVRRHLFASHVPYHEFLVFVSHLRAIRPASPHPPAMSTLTPLPFLARIIAEDSDPTVRLDLAPSLNWLSRRSVIGAIHSGQLTIEPIQFTTLLEELAPPNIPTSHHHTHVVCALCGMLIYSSASDSSPSTPTTPYPLRSGSQSASWSTTLFKNVRSGEITLPALTGQNHRHTPSFGSAPTEPPTQVYIFRLDSTSSGLPMSLPLSTQQPGTPTRQAIYPLCTSGWCLARLRTTCSLWAFVRTSIVEKVWEEPPMPTPTHGIPKPGVNGFEKKPSSEGENVNDRNSSSTRDSSPRRPKVGSALGSLWGSMQRSLSGTPAVSKSQSTENVSTKISEPPKERPKLPPRDPSRKTLPPPPPTHPAVSHSPRNSTSQSSTNATVHRVPPPFKEEKESLPPVVAAAAAAAAAAAASPPPPLPKRNRGRERTITPELNGDVKASRDTAHPEASSTEQPKEPSAPAPQEETAPALKEPEAVVGAPAKQEAPHAEGEAKAAAADEGAAPKSGLIVATGPISQSTSTESFSTPTEELQVDIAAKAPSSEPSSEPSPQKTPTTEQAPAVESAPEIVSAEPPAIEAAASTPTTPTPVAEAKSQPPSRTGSPAPPPLPRRAAARTRPLSALVPQNEEQPKRDSIDVPSQTEAIPEPAPVTEEPTSTEQKAEEAKETVPEQTQDEAKENSDAEASAPAPEASSDAPAPVEPIAVVDATSHITEEPQSIAATENPPATPPTEDSAPASDSDAVAAPADVLKTDLATAPAEKTSLVNGHAESAHSESESVSEAPPAYAPGEVQANGDSKEKLVDNVAEEPDNGQYIGDATWEERTYKELVRLREEMFWARIGAIVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAI2</accession>
    <name>A0A4Q9PAI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 16">Diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5 16">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_982585</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Endoplasmic reticulum membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5 16"/>
    <dbReference type="EMBL" id="ML145319">
        <property type="protein sequence ID" value="TBU51458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAI2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAI2"/>
    <dbReference type="OMA" id="IMGVACT"/>
    <dbReference type="UniPathway" id="UPA00282"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14 16" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU51458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="416" mass="46695" checksum="ADF99A855A9E81A6" modified="2019-07-31" version="1">MEVHKTFTSMTRTVSSTSLRERLSSLSSLTATPLNPVANLHAQIEFVPSKIPRKRRLQTLAVAIWSTTIIWHVFPVPETHEAPFTLSSFPPLWPLLAAYWIWIAYVDKSPEHGGRLSPWFRSLRFWRYFADYYPASFLKTCDLPPDRPYVFGYHPHGIIGMGAICTFATESTGFSAAFPGIVPHLLTLASNFRVPFYRDIILAMGVCSVSKQSCSNILKGGPGQAITIVVGGAAESLSAHPGTADLTLRKRLGFIKIAIQHGADLVPVFSFGENDIFQQMPNDKGTTLYTLQKKFQNVFGFTLPLFHGRGLLNYNLGLMPYRRRIVAVIGQPIHVVQCDKPTLEEVIHVQQQYIDELMRYVARPSSPRRPVVLSPCRPIAAAGRSLTLRIAGPCRIWNTYKDEFAKTRLRELNIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAY4</accession>
    <name>A0A4Q9PAY4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_279652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145282">
        <property type="protein sequence ID" value="TBU51844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAY4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="319" mass="35797" checksum="14D59849CB0A3CE9" modified="2019-07-31" version="1">MSESIAEVAAAQEALISKYFDLSSATLYIYDHLISLDSEIELFWRRRAFASALFLLNRYLTLFCMLAQFTIFIIPPPAQQSLPRLKVYDYVYYISVIGQFPVWGAISSIRAFVVCSDLRRSICRWSSAITVFALYTAPCGINAYGRFAPVVPSAEAQKMFVIASRMCLSVADIIVVVVTWRQMRRQMKLFSTAVRRRYRPSYASVLLRDGTIYFLVLVPFNAVHLIFSLYSILGQSPRYPTSGIPIFTTPITAILISKFLVHLQEIESATGTSSQSAWQTGLLVLQPSVGPRSREHSPEPSTSTPCRRDGTREGSLQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB18</accession>
    <name>A0A4Q9PB18_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_941351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145279">
        <property type="protein sequence ID" value="TBU51884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB18"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020896362" evidence="3">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="194" mass="22319" checksum="05BB040C7C792C20" modified="2019-07-31" version="1">MLHCLRVLLSTILPICLLVIPRVASLPGTSTEGRKAYTYRGSDFPTWWNIPSLEDVYLSHEDSIHYALETDLGAAEWKSILPSGGSTLYFGEDLRPFTLSMFHQLRCLDILRDILVEFHYNKSPDATYKNPEMAKHCMNYLRQTVICRADTRLEHVRAASGPRVVVSDLTHSCKDWTAVYEAAERNYQYFLENR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB42</accession>
    <name>A0A4Q9PB42_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_809552</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB42"/>
    <dbReference type="OMA" id="TFPITWT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11407" checksum="7F60955F59845D81" modified="2019-07-31" version="1">MQLTTILTLAGVALSAAFGVSAKQDAKATTIWQPTATVVQTKTYTGTRVEEIWTTTPPYEWLTTYPITWTATETETQYKPVVTNVARQVVGERRHARDFQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCE7</accession>
    <name>A0A4Q9PCE7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_832109</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145249">
        <property type="protein sequence ID" value="TBU52470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCE7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCE7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055442">
        <property type="entry name" value="Beta-prop_EML-like_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23414">
        <property type="entry name" value="Beta-prop_EML_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="EML-like second beta-propeller" evidence="5">
        <location>
            <begin position="343"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="419"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="503"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="545"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="587"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="629"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU52470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="669" mass="73331" checksum="E1AD2CF5371A049B" modified="2019-07-31" version="1">MQTKFTQRRHIITYLRTHFESWSEYANSEECGLTIKQEDLRFVSGTVKTTRWASSAWAGSHKNKQASVTVQVPNMASLDLKVSVEEQNLPYSWYNKGPITDPKSKAPAVGLLTNQQASLPSTTSTEETRDQCLFFNYFTAKKRLWFNRVMQGAAGPHQLPPGGPDPEGNEPIGGESGSDDEALSTYTSYNPVAYLLDYILAHSEADMAIASDRDLIAIFGEEGVPEDIYAGLEELQPEVEVDESGVGTVSVDTTWLDKQLASETAILTRTEGDINEAGAHSGSEELQATLGGPETETTSFDHQNPLEQDPEDEDEDDPEAAERRKAQMAVWEPAANGHTGSITALAVSPDSKWVASGSDDTMIILWDTEEQSVVRKWESHGDIVWHLAFSPDSARLASSGGEGRIMIWNVDSGEHLGTLGGHTEAVHTVVWSPDGTKLGSGSDDMTVRIWDAQNYECLHLLEGHNAMVTFVLFSHNGQYLASGGADYNCRLWNVDTGTLHKELTGHRGMVWTAAFDPVDNRIATASDDGSVRVWKVETGEELVVLHEHHGPVWVVAFTEDGKEILSGSSDSTLKICDSFSSKRVAIMEGHDSMVNAASLSPDGRYIASASSDNTVRFWRKKDGTNMKTFNEHNDKVTHVVFSPDGVTLSSGSDDGTVRIRVLKDFVKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCN4</accession>
    <name>A0A4Q9PCN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_983060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145478">
        <property type="protein sequence ID" value="TBU50987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCN4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="674" mass="74600" checksum="581D2330975D949C" modified="2019-07-31" version="1" fragment="single">YIGVFCYSPGALGALRSQPYHTSPPRTTYLDSRNSARPATQPVASSSRLPPPPSPLHHTSSLSSSPSDTIPRTSSSSSVLSDASEATPLGPLTPPDEFQDYGLDRPLDYYDSPPSPPQSLQDQMHVTYALDNMHLAKILLLKLRGIDVSGDDDPRIAAVRDEDFSSSFVPEGGLRLDADAEVRVQEAERRAREARQRRLREERLRQCEQVWERSMQRFRCEKARIARKKEEAQHERREAERLAKEREREREHQRKAEAARAARGSQLRIASGQPRQLVCYDSLRNADSRFPKATRVERKADDSSKFLYDIMPSPPSCPMSLSRPTSRSPTDKDSPTLPRAQRELALKHAKSVSRSVAFSDVLTAMHGPLFGEEEDNRSYMRRDKQQEELLSILLEPVKLVEKGKSGQDTIPELVMQAKKSVTARALRASTADSISSTSSADSSSISTVTRSGSWFSFGSKSSFRSTSTTLNTPSSSPLTSCKLAVLSSPLSTSPPSDSPIHARRQSSKPPPSAPTVPASEHPLALPTPPRAKRKEPLAVGRARPLTRRVSLSGQVDEQSPPSPTTTLVHHVSRSVYTIIDFAAQFQRAYVRATMFSAGVDLYGERSRSTSGSRSRSPVGRVRYASSPRRLESGLKPEGYRASSLDVQVFADLDMYRDDSAPQYQRTLIPLFSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD64</accession>
    <name>A0A4Q9PD64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_963153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145370">
        <property type="protein sequence ID" value="TBU51177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD64"/>
    <dbReference type="STRING" id="114155.A0A4Q9PD64"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15926" checksum="D5F44566A650F345" modified="2019-07-31" version="1">MATTSVSDTSKSGTHSTSKRPITDILSETFPPYDDQAELVTPFDNETKRDAEFLEKLNSMLLELIIEFHAWSSARPMHESDQMADVLEKEIKGLRNIESEQGTSSAPIYFSIPSASPSKTRQRLYEFITRIKLALAALTGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDM6</accession>
    <name>A0A4Q9PDM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_982983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145421">
        <property type="protein sequence ID" value="TBU51061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDM6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9385" checksum="E43A8F2C39738E0A" modified="2019-07-31" version="1" fragment="single">NRVRIPVRWSNLQQALQALDFEVENRKGLKRRVVAPSHLGGACTTLMQPKNGIIAPPSQAYVVSQLSQRRGLTAEYLENLAKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDY3</accession>
    <name>A0A4Q9PDY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CobW-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_938796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145226">
        <property type="protein sequence ID" value="TBU53090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDY3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDY3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF62">
        <property type="entry name" value="COBW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="40183" checksum="5A40B064900AF765" modified="2019-07-31" version="1">MTTSETNNIPITVFTGFLGAGKTSIILSLLPRLPRDYRVVLLKNEFGDVEVDSQLAKQSSLTAVSEILNGCMCCVLVGQMKTALLEIREKFRPDRLFIECSGSAFPATLAFQIRELERETNGDFKLDAIVTVIDAENFTGYEDTSPTAKMQASYTDLILINKWEHISERDLDILIDHLNTLNDTTPKVKCHGREGVDPSVVMGIDSKLFRLGSFEHTDVPHHDEVQTVTIYKGRKPTYVHSPTSHDGHAHTDHAHCGHADNSVDRPGSKSSTVVQDAISSISQDTLADALGVLSKETVWRVKGFVKLESGYHILNWAFGRYELTSIGEVPEDVGVVKLTVMGERGEVKRASRKLAEKLQAEMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEC2</accession>
    <name>A0A4Q9PEC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_962182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145221">
        <property type="protein sequence ID" value="TBU53209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEC2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEC2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044714">
        <property type="entry name" value="AtSIBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46672:SF1">
        <property type="entry name" value="OS08G0103600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46672">
        <property type="entry name" value="OS08G0495500 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="557" mass="61743" checksum="C0791B14BA0F6E3F" modified="2019-07-31" version="1">MSSSRSPDVSATDDKQKKAVATKAPPPFDREDADLIISTRDNVDFHVHRVVLSLGSTVFENMFSFPQPAGTDVARPHVDISEDSKAMETFLRIIYPIPDPEFKSLQHLHSVLAAGTKYDAAAVIALARKKLTESSFLQDDPLRVFAIACLFHMADEAKMAAELAVRKSRVTGTCPELDAIPAGAYHRLLALQRDYERSRTSSFLSNLEAVFSGFTPLRRNANETDDRQTGAKFRRGDIDTTFVVSSDPILASDVIIRSSDNHDFYVHRVLLTLASPTMLSMLESVADNDVAVHTGSIPVPIYKMPESVLVVRDILRHCYPIQHSSANDIHDPKHFLAVLSAVRKYQLKGAEAAMKGQWKLMAHLDPLRFYFAAVEYRWKDEALESARGLIQHSQTVNSIHSLYIPSMETIPNAAYYRLLLYVNQCVKAATSGITVQSLPATSCASPWLNRSRKAYFRESVTLHAIPPEALRNLLSEVTAAVRDKPLGSSIAATSPAGQAFLKKLVSFKCHCSTNIQVPPCSEVERLTWGFAFLKQYGETIDKAVSNVVFETKFIDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEX0</accession>
    <name>A0A4Q9PEX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145214">
        <property type="protein sequence ID" value="TBU53449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEX0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="406" mass="45638" checksum="9258FEAA7A769749" modified="2019-07-31" version="1">MSSLALEDTRRIEAVLWQPAAALTDILVELLEDRGRAECALATLNDESFARVVSHLNNGFPKTAKEFCGSMWSSMLSKFVATLVEMAVTTDLGTGGSKKSLDARRNGVVLAGSALAEIARLSSKTGWSQGDIAVKVFADLNLKTPSTVQELAMKEREILQEQLRMLKHSLKILRTPASVAALSKRQGISTVNADVFENTISITAPFYSENVKGFGEWKLFITDAANAHLRQLRRRSPDTLLIVLRKMRDLSRGHFSPDNQILISDTEKSVPIFKAKMTGDTRLVYQVDCVTDPESRKECQALRIFGVYNHDELYRMKQFWVSLGRDLGRQGKTYRERCRQRSQGRNTSNDVFSPQVFSCHADDNEPLETLTTWEIPSELDYSEMLTMHRFVGFSKALLNSKWSRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF12</accession>
    <name>A0A4Q9PF12_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1005093</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145308">
        <property type="protein sequence ID" value="TBU51561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF12"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF12"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="83"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="380" mass="41278" checksum="4A3FA925132E5CA4" modified="2019-07-31" version="1" fragment="single">MFTFHCKPNKSEDNGGPPFIRTSPSLPELSAQGIPWPSNLVDLSQLPQDTASSPPRGAAKTSFTADAAHPVPFHEPWLSPGTPPYVFNVMVAGAQGVGKTSLLRLLLDMVDISLTATADQKAVVERFLRGPPKGTETIHSACIEICESKYDRLLLSIIDTPGLDFRKGHECKLEHQVSTIVKYLDSQFADTLNEESKVVRQSKGDQHIGLCIYTIDPSSVLTEGACHTQSPYPTKVRSEVTVSYNLLDLSSMSDDTDSEDEEDKNGLTMSPADICVMRRIAARANMLPSVWRDLRAADLDFGAFGPVVMDDAARSPADERANGNWNGHGHTNSTSSSDNNNKRTAVASDPPGPSSSCARRVSRSRSRLEMSETALAEDPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF88</accession>
    <name>A0A4Q9PF88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_991528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF88"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF88"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02663">
        <property type="entry name" value="Peptidase_C19G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF733">
        <property type="entry name" value="RE52890P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="7">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="391"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="562"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="602"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="709"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="803"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="909" mass="97636" checksum="58443E0BDCFD13E3" modified="2019-07-31" version="1">MPTPSFRPSTFAVLFANFSSNIQTLPFPTFRRSLPSLPYPYPSQAIPSRPPLFRARSPSALNPHAPPAIPIPPSPPTLFSALRSLFLHISRNPADKGTVAPKAFIDKLKELNEIFRPAQHQDAHEFLNYLLNRIMEDMEDDGRKLGSNANGVEKSGEDLSTSIATLSTQPAPSTSTAQATAYHSTIVHRLFEGVLTSETRCLTCETVSSRDESFIDLSIDIEQNSSVTACLRQFSASEMLCQKNKFFCDSCCDLQEAEKRMKIKKLPNVLALHLKRFKYQEDLGKYIKLAYRVAFPLELRLFNTVDDAEDPDRLYELFAIVVHIGNGPHHGHYVTIIKARGVWTLFDDDSVSTVKESDIPKYFGDSNSGTAYVLYYQAVDIDLAALGLKSASPPPGSRATTDLGSVPGKPVGIATTEPSEQSHTPISPSLQRPPGLHSSVDDLNLSDKSDSPLPTPGAAQPISSTNNTSDSLPVIAPTPSYPNLVVSVPDGPPTPGPMSPSREKHSHGTFGKALKTLRQTPSLRLKTPNGKDGYRRSVTDSSANLLPLSSTPASPRTRRPQTTETTATASTTETSTHETVPSVPSSPLPSKGYAFPNGTAATRDKERTPEKKSSTWFRRKSTREETMPVASPSLSRLGRRGSEAAISGTSSPAIPSSPVPPFASGSRTDPPFSPSSHKKSAPDLSKSVRREKRASGNASSKLPPRPSTAGATMTSSSRGYHSGVGVPPPLPTLPGSPMTPGKGTAADSFFPPKRKERDAADGSPRQPEEASLPPLPSTPAGDSGRERQREAQSDSVPPPARISQSDSQYSSTTYSHSNHTSHTHGHARPGPPGSAYSEPDPYATSLSFGRSGGGGVGDTPVVPHSSSSSSSTGNNWKRATRKLSLTAPNIFGKKDRERKEVPPPSAFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFY0</accession>
    <name>A0A4Q9PFY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_128567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145204">
        <property type="protein sequence ID" value="TBU53808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFY0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="132" mass="14451" checksum="A55EBBFF5F53DB71" modified="2019-07-31" version="1">MSWGFGSVQRHVQHCFGDRSLAPASAPDIYSFAGGTLRRVTRHGRVRDEHVDVSGIKDSFTQTVRLRRADKAAVTHPLRTPRGWLSGRRSGRRSLHCSMANLSRTSMSTARLTDSSMILAADTGALRGTSTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG35</accession>
    <name>A0A4Q9PG35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_766753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG35"/>
    <dbReference type="OMA" id="RAWLPAC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="6112" checksum="FA866750A00B8920" modified="2019-07-31" version="1" fragment="single">MDNQSILQSPSKHNLLPAETIDNIIDYLHDDVTTLAASSLVCRAWLPACRYHLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHV2</accession>
    <name>A0A4Q9PHV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_221836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145243">
        <property type="protein sequence ID" value="TBU52616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHV2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="254" mass="26008" checksum="259AB3EAFA11596A" modified="2019-07-31" version="1">MAPAHRKSTTTSAHANASASASATAGASTSVSTNASGSAIVVPTAGALAVSAPPPISAFVVRPSQAPGITPLWNPIVVLAFLWAALFLALCATAVCLLVRGRRREARAHPVRRVTIAGTARARGKAVAVLANGPESEKGGSQHSGGSRDKDREGGDGAEEREQDLSERQSVTSAGRERERERERTSPPPPALPLGLPSCSSSGLPLSASMSKSLDPSQESQTTPVPQVLVWLPSFRNGAGGQAQASEEGHDATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI54</accession>
    <name>A0A4Q9PI54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_937570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145208">
        <property type="protein sequence ID" value="TBU53651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI54"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="10"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="30265" checksum="D857F3C43B25348A" modified="2019-07-31" version="1">MEPIVFYDIPADAFQDRMWSPNTWKTRYVLNIKGLPYTTVWVEFPDIAAVSRKIGALPTQEGPDGSPIYTLPAIYDPNTKSAISESAAIARYLEKTYPNFKPTLIPPETDALHAAFEAVFWKTLWPDLRQIMLPPTNALLNPRSAEYFRRTREAMDGEKLEDWTPAGSEKRERHWRGVERALDTFAEWLGTYGNREKLFFTGVDISYADITVASFLIWIERVLGKDSKEWQDVLRWNNGRWARFMDAFRKYEAVDVGVDAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIB7</accession>
    <name>A0A4Q9PIB7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_181568</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3 8"/>
    <dbReference type="EMBL" id="ML145226">
        <property type="protein sequence ID" value="TBU53076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIB7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIB7"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00570">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006406">
        <property type="entry name" value="Nic_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01514">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003704">
        <property type="entry name" value="PRK05321.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="10">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="184"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU53076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="431" mass="49417" checksum="70CD719CC0CFA7E7" modified="2019-07-31" version="1">MEHKDHTVTPLSLLDTDLYKFTMQQAVLQHFPGVEGTYRFTHRDKDVYFTRECFDRFRRSAAQFDKLKLTKEERAWLEKACPYFETSYLDYLEAYRFNPDQLRLRFEPIPEDKERNERGDLSARGRIQIEAVGPWQETILWEVPLMACLSEIYFTTVDTDWDYEGQEDAAYQKATVLLQADCVFNEFGTRRRRSARTQELVLQGILRAERDHPGRGKVNGTSNVFFAMKFNVNPVGTIAHEWFMGVGAQKGYEHANGTALELWEKTYPNALLIALTDTFSTEAFYKDFLANKHFAEHWTGLRQDSGDPFVYAPRAKEIYQQLGVDHTKKIIIYSDALNVDKALQLKKQCDELGFKCAFGIGTSLSNDFKKKSSGGSEKSKALNMVIKLSSVDGKPTVKISDEITKNTGDPTTVEYVKELFGIPVTKEDEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIL2</accession>
    <name>A0A4Q9PIL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145204">
        <property type="protein sequence ID" value="TBU53826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIL2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="406"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="683" mass="72655" checksum="408C1D465CDCE772" modified="2019-07-31" version="1">MTSPPSFSFSKPAMPGDAVSVTVLVEDSPAMAARWPDIRDAYLPNLLDNLRAADPSAEMEARWLTTSSASSAPSFPITDTAEARSVPELPLNTSGIVKLSPAIITNAISTLSSTTRQQNTTRHLILVAATGPSTTGLNDATPSGFDTWDDIAMVLKQQYIRLHVILSIGAEMRTYHELFKRSLQLQNNSEVPAWFPVDSRRYSIRLSGRPQYVRGSGAVPIALVSTAIPEDPFNNPSPGSSPEAASPPATTSSPSSPIQPNSPGSRKLPHSPTTPRTRPRAPDSPQSPPASEGGGLVSYLQQMHGLTKKKSYGIKAPKKTYADIRLPGSGRPILPRLEVPQPQSDLYAYPTFDNGPASEIRAPSSEPQIPPPRRHSVDQLPASSLVARTSNEDRRARRRGPWLPIAPLVSSTPSSPATATSPGTLAALQSLASMTPRLPDFVTKERMASSVPTDHRPVYLMTASAVPMTSDPHPSAAYYASNASAWSQHSSAVSSSSPISSPTHALSPVYQTSPPTPSLVGSDYAYSNSPPSSAASTPASLCAPANDSGDDQPFIVTPEYEATVNARFDEAVRSGAMQASMTPAIHSAVPSLSSPSYAPSIPAPVHQEQFYPALSQTQPHQAMYHQGETGYPMYSVAGHQSDYLSSGTAAQANAAWIQYDYAGNAYMAPVSGYSPPQGHWYPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ98</accession>
    <name>A0A4Q9PJ98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_936472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ98"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5853" checksum="3BB11D55F17585D3" modified="2019-07-31" version="1">MSFFYCLSTFAQPSLTALSAPLSHFCRPFLSAIALLVVCSRLLHVARHCRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJX6</accession>
    <name>A0A4Q9PJX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_76658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145189">
        <property type="protein sequence ID" value="TBU54429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJX6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18167" checksum="3922C5E5C149C5A5" modified="2019-07-31" version="1">MCLRSICPVESLCTRIRSIYLIRLYPLDFYSSCLSAPSACVLFPFSPLLFSLATCVPFAFRCDYPFPCPDVLLLAFLFAFALSGMSLSVVHIHRVAPTPSPTFVTSSVSHPCICISRSSLSSPPRLRLLRNSSRSIHCPIRHRIVLYTCPAHIDSSPSSSYAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKZ3</accession>
    <name>A0A4Q9PKZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Small heat shock protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_934909</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKZ3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKZ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="41"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU54812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="154" mass="17252" checksum="F69B2252D9533F93" modified="2019-07-31" version="1">MSLTFFTEPFYSLSDFDRLFDEAFNARTSNAVSQRGQNENAASRPLRPGMDLHEDKEKNLVTAQFELPGLTKDKVSIDLRDNVLTVSGESSISSEHDEKGYAVRERRYGKFSRALPVPQGIKPEEIKATMENGVLSVTFPRTTPEQAPKKITIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL45</accession>
    <name>A0A4Q9PL45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">homocitrate synthase</fullName>
            <ecNumber evidence="5">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_934832</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:12930"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="5"/>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL45"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL45"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00028"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07948">
        <property type="entry name" value="DRE_TIM_HCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.260:FF:000002">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000032">
        <property type="entry name" value="Homocitrate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02222">
        <property type="entry name" value="Homocitr_synth_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050073">
        <property type="entry name" value="2-IPM_HCS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048253">
        <property type="entry name" value="DRE_TIM_HCS_fun_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011872">
        <property type="entry name" value="Homocitrate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054691">
        <property type="entry name" value="LeuA/HCS_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02146">
        <property type="entry name" value="LysS_fung_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277:SF48">
        <property type="entry name" value="HOMOCITRATE SYNTHASE, CYTOSOLIC ISOZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10277">
        <property type="entry name" value="HOMOCITRATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22617">
        <property type="entry name" value="HCS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="15">
        <location>
            <begin position="77"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="22"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU54899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="480" mass="51972" checksum="9C528A39FE64444A" modified="2019-07-31" version="1">MCPCQNGASQPADNSEMVQVPLNGSTSAHSVPSTANGANGHPTANGSANGTANGRPTRPLNPYAPRASDFLSNVSNFKIIESTLREGEQFANAFFDTKTKIAIAKALDAFGVEYIELTSPAASEQSRRDCEEICKLGLKAKILTHIRCHMDDARIAVETGVDGVDVVIGTSSFLREFSHGKDMAYITKTAIEVINYVKSKGIEVRFSSEDSFRSDLVDLLSIYQTVDRIGVNRVGIADTVGCANPRQVYDLVRTLRGVVSCDIEVHLHNDTGMAIANAYCALEAGATHIDTSVLGIGERVGITPLGGLVACLYAANPEYVKSKYNLPMLREIENLVAEAVEVNVPFMNPITGYCAFTHKAGIHAKAILNNPSTYEILKPEDFGLTRYVSIGHRLTGWNAVKSRVEQLGLKLTDEEVKDVTAKIKELADVRTQSMDDVDTLLRVYHSGIQSGELAVGQKEALDRLLQKHREESRSAVAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL54</accession>
    <name>A0A4Q9PL54_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_723513</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL54"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020939134" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="29"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU54913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="543" mass="59025" checksum="47BC0E3432847BB4" modified="2019-07-31" version="1">MGRSFCGVLVSSALLLLSSTSASPVSDPLVIHTPSGTFRGVATANGTEQWLGIPFAQPPIGSLRFKAPVPFINRSTSIQDASTFGNACPQVPSTSLGAPQSEDCLFLNVFRPSNVSTSEKIPVLFWIHGGAFMQGAASDPEYNPTFIIQRSVATGKPIIFVSTNYRLNTFGFLASRHVPPSDLNVGLQDQTAALEFVQHNIAAFGGDPEKVTIWGQSAGAGSVEAHVLFQSSTKLFRAAMFDSSTGPFKTAPSPSTYDESGKPYERLVNLTGCPSGPQSFACLRSLPFETLQNVTVAMTNEVLNQQLWQPTVGPAGSFVSERPSQRIASGNFLHVPILAGTNLNEGTTFSQSVRNLSVPSSEEDAAFDTFIQELLIDPSTVTQDVYDTINTLYPANDSSLGAPFNTGDSLYDRAEAWYSDNMFLSPRRLLFNKAASLQPLFGYFFAEFIPGQDPSLGVFHASELILLFGQFPAVEQEFAIQMVDFYVNFVNDLNPGAPWPQFTQTNKAVLQLMRDNITAILDDFLIDKTTFLDSAYVLNEFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLF2</accession>
    <name>A0A4Q9PLF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_908619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLF2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="43278" checksum="69FD9DC2F7C79CE4" modified="2019-07-31" version="1">MNPREKLKLPSGSDISARSYRAVDIVHPVCDRPLFSLPAFSESIPPANTVYGVDRQLVLDACRIITNYTSEDQADYHALDRAGQQAASTENALLEPGRYYHILSPSDTTTNYRIVADFRAWDFPERVLPHWSWPRDNEETVELQDQKDWLAANGMNVITLRRDVRYCLEGHVFVFCPVDHHTFLTYVLREGVPDYAELLHRRPVTFPRRVPAEFIYARFAYTVISLLQSSPYFDDFPIPDAVKLAEKTRASGQKRNMPSRKQKEPKLDTVDEGDNSDTYESDTKETSTSSKSTQSESEEDVAARNERWKAQFATWFPTLEVEHPPETPWVGLHPETPHALRPMSGYIRKNPLVWQTSTTPADATRPDDEGYLAKMLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMT9</accession>
    <name>A0A4Q9PMT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_933371</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMT9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMT9"/>
    <dbReference type="OMA" id="CAIVTIQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="385" mass="42725" checksum="6C1E1BE121DED9E3" modified="2019-07-31" version="1">MASGRLELDLSMGMLLIGLAATASLFGVTFSQAMWYYRRYPRDRKILQLLVTTVWGMDALSLVLYSSSLWDYLVRKNLHYFGGLSIPWMSNAQIVVNAIAIAIIQSFYTYRIWTLTRQKVLTGFLLAFVSADFALALLLFFKSINTQSLADYIRLTPFDIAMSCTTATTDIILCGTLVTLLARSRTGSAGSDRLINRLLFYTINTGLVTSMCALTSLITVLVLPEASVYVLFYYIGARMYTVSLLATLNAREHLRIQAEQLGDASIPRLTRTSNSVSRRSVRAVVDAMSPSKEIVVAIQRDTTVTFEERSEEDLHDARRRGPYRYQSQSPTEPRSPKLVALLTNNSLSPPKRRDSIGTSSLPDSQLASSSSSGSGTRVQAPSDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNQ0</accession>
    <name>A0A4Q9PNQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbohydrate esterase family 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_932464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020355705" description="Carbohydrate esterase family 16 protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="37036" checksum="33F9C26078509B29" modified="2019-07-31" version="1">MKHLAGLLLLALSLAPTRAVHLPVSGVRVSEPLSQVARQDNDDITLAVSPVCGSLSGNVSDVNAGIHLPSVKTIVAFGDSYTDGGRQDGGPLPPPVITPPDAEAGGRSTNGRVWVEDLAGPFNATVMDYAQSGAVTDLSLWPSAVKKVDFLGQMQTFLNQSNDLDPETTLYIVFFGINDYEDSKTDGEANLQAAAQVILSQIRILASASTSARSFLVTDVYGRGTHTPAGDAMVQTIFSGLSDLNRGINSTGNGEGLNGKPPGPALKVAFAEFARIWDGVLDGSPGFEAFGYTSTDACIVDCSDTFCSTDGMCDDPDHYFYYIPGHPNKEGHVLMAEYVREVLDRCIEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNX0</accession>
    <name>A0A4Q9PNX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_950412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU55991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNX0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU55991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="609" mass="68357" checksum="517B02D0EC221D2C" modified="2019-07-31" version="1">MAAVAPDGERKLNPPPQPTPTLSAPVIGRQPGPLHDSAPPPATPGATNGYCRFTRNAVLEGKRTGRVASGVVSELDPDAVNRSGEEGKGLAPDDAAYEKTFLQALYGHVRAGQLEDEIDLCRKANQPWRAASLRGVLLFQWRTISNAPWDDDAMDEEDTEDSQQWSGNVRRQMWKTVCQRTALNAVCRTQDHLWVLVSIASEERLSLGLARIARECFWESDLGTLEGSAASEAGGVPDEEVEEEWEEEVKQMLEALEAVQVAEGAPVEHPYHISQLHIILDKTDELLRSFGNGLQEADEYPALTRFFAHLCLFLQLIDMPVSPLATQVILEAYLRVLESAGQRELIAMYAGALGDNAVERYALFLASFELSGDMHKRRLALTRAREHGLDIERVAITTFLESTYDTALEQVNVVLRYFLGTIARMLLDMLPPELGSLPEPEDQATEFMHYRQFFNVWELLSRVVETQALEQPQMNRGTRLAWLDDYQTLIEQAREQVIKLLTTDWLMSDAEVHNGDRRRRDLSRIRQIYIPELIIRLHSILVGSRSRIPENIKHALSLVNIVADSRYRLNEDFSNQDGRQLDDYLGAVRQAVLAGLEGGGSDPFRILTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNX3</accession>
    <name>A0A4Q9PNX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_932695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNX3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNX3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056672">
        <property type="entry name" value="DUF7770"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24968">
        <property type="entry name" value="DUF7770"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7770" evidence="1">
        <location>
            <begin position="43"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21676" checksum="14B47CA3117206C1" modified="2019-07-31" version="1">MLRTHLSQHVDEPRQDTSTMAATIYDKALRPVDKDRRVTQITVTASLYAPAGSEGVGIFHWRLYLVLGPDRVSTSRAVLLDMVPTNPPFGTLIIASKDNAHSNALIKIELPIASVDGLTVRQVIDLIVSNRMDRYKFDASGSGCLFWIWNVLQQLQNARLVEDGAVAKLQDFHAEQARLQPGKIPLPLRRGEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPC9</accession>
    <name>A0A4Q9PPC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_932215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPC9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="184"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU56035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="692" mass="74764" checksum="B8D7C1E77818F2C9" modified="2019-07-31" version="1">MLVSQLVADVDDMHLLTSLIGLAIGHLAAPLVCGFAIPSSSSLKSDIILLYNNDLNLSQQPTQRSALLLSTPQIHAHASSACAALGEKLLPVNKTFLTIDLVPLLQYQVFQKKFPAAQQFWVASSGPVCRTVDSKGVVSSSLTCSRELPVLCSQSAGFQAAAQPTTSLMIKSQDLTITGFRDQTSFKFFGIPYVDPPARWEYPTVYTGNKTIDARNFGSECIQTGSTSSSEDCLFLNIWTPFIPSPNTKTSLKAVMFWIHGGAFTGGTGSDPTFDGNAFASRGDVVLVTINYRLSTLGFLALDDGKTNGNFGLADQIAALDWVREHIAAFGGDKDRITIFGQSAGAASVRALMGSPKAIGKYAAAIPESNLAGENYATTYSLYYTIAAEVSLVADAIVSAVNCSDSSDVLFCLRGVDANTVVNLPTVARFIVVDGTYVVHTQLPVDGSGAVADIHTMMGFMRDDGAAFIGYPTDGNLTEGLIGASLSTTVANNTLFPEPSGANATLNVFNITAGVTTDVEFRCLDQATAFSGVTHNLFKSVWFYEFNRSYQLSGYDPNFPTCEAPITNEHPFGDTSAEYFKCHSGELYYVFGSMPADRPYRDNQDLPFMQRIVDVWSSFARTFNPNPDPGFLAARGFTSTAQQLAAQRKWEPVTKANLHGKPVQQLQWESVMVPFGQQEQCEFLGFPLTYYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPH1</accession>
    <name>A0A4Q9PPH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Peptidase S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_636882</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPH1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000368">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020687985" evidence="7">
        <location>
            <begin position="28"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="526" mass="58070" checksum="64576A6702BA9EE2" modified="2019-07-31" version="1">MPSFKSGVLGVGALALALLLRSDGAEAIRPVNPQVVKLAAKKATRTAGHAKRATPTFPLYNFTQPLDHFSDTGFTFQQRYWVSDRHYKPGGPVIVFEAGEGPGDERMPILDTGIIDILANATNGLGIVLEHRYYGKSVPVLNFTTDSLRWLNNEQAAADSANFIDNVTIPGIKGDITAPGTPWIYYGGSYGGARAAHMRVLYPDIVFGSISSSGVTHATVVDWRYFDIIRQYAPQDCVARIVQTVDEVDTLLTRNNHTRNAIKAVFGLSGISYDPDFASLLSSPLGAWQNRNWDPAIDDPSFFDFCEALGPLDNATVTTHGVTISNATAQYANYINQTISLDCPVAQQDECFGSITDPESFSQTDLSQTWRLWNFQVCTQWGFLMTPPPDPATPRIISKLLTKEYAHLTCTLSYPPGEHFAIPAWPNVEDVNKLGGYNIAYDRLAIIDGEDDPWRGDTPHSPDPRAHNRTDTTIRPFKLIPTAVHHWDENGLADPSAEPDFIQTIHHQEVTFVTEWLKGFKPPSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPL9</accession>
    <name>A0A4Q9PPL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_960388</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPL9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPL9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020425884" evidence="9">
        <location>
            <begin position="21"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="464" mass="51243" checksum="134D72A42655CA91" modified="2019-07-31" version="1">MISAIVCTLIALLAWRLVRALTPKSPLDIVPGPIATSFLTGHLSQITDTQSWDFHSHIAEKYGPIVKLRGLLGKPMLYIFDPLSLQHILKDSTLYDEPPWYLQSNCILLGPGLPCVTGETHRKQRKMLTPIFAPKHLRSLVPVFYGVTHKLVSAISTRVGEDPQAVDVLGWMGRAALELIGQSGLGYSFDPLTEDVQDAYGDAVKSYSPVATCAEMMLLRQLTPFVGFLGPSWLRRWLVERLPIPSVQELIRICDTMRAKSSEILQAKKAAIDTHGADHKDIISVLLKANMEVPVGERLPDEEVSGQMSSILFAAMDTTSTALSRILHLLAQHQEVQEKARLEVIEARTAAGGDLDYDQLHALPYLDAVCRETLRLYPPAPQTFRGTTKDAVLPLSQPIHGTDGSVVSELVIPRGTDIVIGMMACNRSKALWGDDAYEWKPERWLGPLPETVERAAIPGVYSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQK1</accession>
    <name>A0A4Q9PQK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_960150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQK1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQK1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23639" checksum="52BED60C0EA139F5" modified="2019-07-31" version="1">MEPHSYTRDNDFFIDVKPLYLRAEGTLFCVPRHYFEKSEVWEGLFTLPATSDSPREGSSEDYPLFLESIKADDLREFLRVLSCRLLAAGDGTSIRFIPTSWLPVLKLASLWNFPKLRALALKYLKSQDCMTRLRISRQYDVKEWFLPALKEVAVRTEPLTMDDVKELGLEFALKVMALREKARGAPCIASDLHDYDIDRILGKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRT9</accession>
    <name>A0A4Q9PRT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_569004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRT9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="115"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="424" mass="46578" checksum="220C413FD50D9C8C" modified="2019-07-31" version="1">MSSSTSHTRTKLANDQLTIMFEHYTDQPGYPDSGPASGRSSPTNSSLPCTPVDNFPHSPLDAAVASEDSWNLIPYDVPWGPEYYHYRAGTLPGPEGACIFLRSPTPLKNRRTQKACNKCRQRKAKCSGTRPACMRCLARGYICEYVEEEKGTFTYNASRARRQREHSASSSEPTEATDSMSDCDTSESILPKQEPGLSTPELSFSDTHSSSFDSTTPSIHFHSHYDDAQYPIMVGYEYEGTVDAFGESAAVGDYYDQASYTVTHGAQAHQLQNASQVYHEATDHHSAASSVHAPRPVRCTSSPSFLSPEERIGTFATSFDSQTPQHCDAMLINLATASEVAPQIMLPHVPPMAPTQASECNAVEYAQPQAMYYYPPAEPTMQFPYLQYQYTVPTYTPGSGVQEAIAPAMLYAMPMPMLPVGMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRV0</accession>
    <name>A0A4Q9PRV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_569226</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRV0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="34847" checksum="DA6802011F551B3C" modified="2019-07-31" version="1">MACGASVVVTQGRGAEAASPPRFGSVRAPLQPLPHGSLFNTYDAPQSCSRPRWPSSLDCLQMSSSQPVESNNAYRRTNRHDDQVRVAPYLTHVVTHHGQLTLIPPQNAGRIRKPGKKKKQSGSRNSLDDEEPRFTTAVPLSSSRKLHPAPAQIRTRKHAISTPSPVSASPTAPASSSRRFDPIVDDQSIPDYPPPSFEDAIAAPYLPPHLSAPVTRDSLQSQPWSHDAVPIDPSSAYTQYQRSMTSSVSSLPAPTSVVAVTPTTIYASPAPSQFEGSPAPTEAPLARIFYQFLRHASTASPAAEVYPTFISRAITTCRPSIAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS49</accession>
    <name>A0A4Q9PS49_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_569814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS49"/>
    <dbReference type="STRING" id="114155.A0A4Q9PS49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046976">
        <property type="term" value="F:histone H3K27 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SET" evidence="3">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="19101" checksum="E37153E7B7A60E94" modified="2019-07-31" version="1">MKAKGKKRSKHRCSFMTLQTRMPKKLAVYQGSFGLGTFATSDIPKESLLGEYIGEYFTMPLTQRARDRADEAQKMVFQHRGLNYLFGLNGDQDSVLDAATVGDPTRCLNHPPKGTKPNAAAEEINVDGDVKIYFTTGKKLVKKGRELLLDYGESYWGPSNNDKNVSDDESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS88</accession>
    <name>A0A4Q9PS88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_561166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS88"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="472" mass="51555" checksum="0AE5878B6D8FF10F" modified="2019-07-31" version="1">MDALNFGFEQSDISSSDVYNALPNDALFSYSSIDSFLAEFDVYTHGSQDGVSHATHESPVDYLPLPVDGFPVDFFLNDLARGGGTGVFSSANSSMEPIVTSDLDSSQTPPTAMGNPGSCGTTNIQREDAGDAAPEEIWPPYEFLFPGFSPEEDEEVVPPFVQMRCQWGDCTEYHRVDKMWSDHISKDGGPHRRDLYASKDRDNVKCLWDNCATVAKLGSLKKHIEDCHLNIRRLSCVYCGYEARKDAYSRMHGFARDCRHNPRVKEAHQRLILSFAPAPLDPSTPLPTIGHMASGSQSSRCLTSTSQSVRYTPYPQASTDASSTPRSRKASRRDRRKRVVTPPTFIPVIPEYQEFLRSAGPSYSSGDFQGSRTSSLGTHMVVPAQSPRNLPAATHHSTVSAPVALSEPSELSAMPMHGGVYGDVGALDGQAALDAMFREAFPEPPTTASEALATSDDLSWIDNILNGSGWNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT38</accession>
    <name>A0A4Q9PT38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_542037</name>
        <name evidence="7" type="ORF">BD311DRAFT_678161</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143599">
        <property type="protein sequence ID" value="TBU21523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT38"/>
    <dbReference type="OrthoDB" id="660550at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597645" evidence="5">
        <location>
            <begin position="24"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="87"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU21523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU57603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="415" mass="43413" checksum="91A89271D1CCB2C6" modified="2019-07-31" version="1">MLSGLRLASVFLGVLSLGLDSDALVVRKSSPVTLQFARRFNFTGTSKILELDQARAKALKARALAHPGRLTRSAITNIDATNQAVEYTATVGVGTPPSDFTLLIDTGSSNTWVGATKQFEETSSTVNTGQLVEVVYGSGFVIGEEFTDTVTLAPGLAIEAQSIGVAIESSGFEGLDGILGIGPTDLTCGTLIPDESACIPTVTDNAFTQGLIGEGQVGVSFEPTTSLEVTNGELTFGGTDPSKFTGDLNFVPITSTAPANEFVGIDQTITYGSAGTTVLASTAGITDTGTTLLLIASDALATYQSLTGAVADENTGLLRLTPAQFADLQSLFFQIGDNTFEFTPNAQAWPRALNTAIGGTNEFVYLIVGDLGTDSGEGFDFVDGMTFLERFYYVFDSANSQVGFATTQFTNAETN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTS7</accession>
    <name>A0A4Q9PTS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_513987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTS7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17780" checksum="AC50AE0BD0380481" modified="2019-07-31" version="1">MQRLTSSSRCTHTAKPSRTELHSLDTEVRHEGRTRTYGHTWIVSCTVAPREPHDAKGMEKKPTPCCITRSRPTQDQGCRGQQRQYLNQLSECTRHACIAWSSRASSPHTRRPCVFLGICRALCAVYSAAAARGRCAGCSLSWISRTLTSWQPYGHEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUF0</accession>
    <name>A0A4Q9PUF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="1">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_927831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RdRP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="1"/>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RDRP core" evidence="3">
        <location>
            <begin position="423"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1179"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="37"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1293" mass="143985" checksum="758CCEB6C0EC6BE6" modified="2019-07-31" version="1">MAESDSEREFWEDDSLSRARAFLSMSKQTSSAQEWESEARDSIPRKEAARPTRATADIGIGTRSTDAEKDADHFPVITRRRPVHDTTPRPPIRSPAASTPQAAQAAASIESPRAHVRAAHDQAMDVDSDSEDDSAYDDLVIDTESEDSEVPSRGPSFAFSTTVESRNASMTSLSSSASMDSSGRKRTGEYEPTYGRPIIPGPSTTRRKVARTTQQTATLPSPRPVPQTPSRSGNVTRTNWSESPAPYRETIDTPTTSRISNAVGALGLDEQPSSASVGPSRTKAQTQALDPSSFSGVYILAHDKDMQKLFDKIPLSWGVQYEIARGVSLGLWSWDTVRKAKLESLRGPNNNAASRVSQVLGRPLCDMSPSDAAIWIELDREDAAIIENRSRGLGLQGDFKEKPNWYGGQIQQIARLESDGESFRLTLAKMEMRKSYRFARFLHSRRIIQVSIPQSIVNNRAQDLRAFFTQKFVLCGRVFVAFDAKDKKMFLMEIPEQYERDARVPGDEHRISLEDFVAWHNPMHRNGQQPISKWATRFDLGFSVSVPVISIALENMHFMKDEAVLNDDQDWKPPPECILTDGCGWMNGAALSALAKQIGLEERPTAVQGRFGGAKGLWILHPREQSSNGAPKIWIRDSQVKVKLDLNNLHPAHTIFDLLAPPRVTLPSRLSKLTVLNLAYNGVPKETFVELMKDTIEEEVKPLTQWTGPKAMFLLWKAVERVGGVSMKRALQHALGTSRALGLIGRSMQDLVDRDDEPPEALEQLATETSDLGGDVSEETISTYTALRDPITGQPLTIHGVSLDLIQAGFNPLKLEFLYEKLKKIVTMAIDDIISDYHISVPLSAEAFIIPDPYGILNEREIHFKSTKNLKDPLEDMNPHQLLGEVLIYRNPCRLPSDVQKVTAVQCDVLAAYTDVIVLPTVGARSFASYLAGGDVAVVIYDDRLVKDFTTPPVTQEPPDFIKNNFEDMGTIKQVSDLAKDLTQLDNDPDARRRMLQESLLSGLSITPIGMYSEFHEGTAYAYGYDAPETIRNAFMFNTVLDSRKTGYRIRQEVLKDDKRKYQRQLPDCMLSRKAAEKKQQSWDRGDIPFRRDRRLGQFILDELFAAGRKMRDEQITRYDRLKSHASFSMDDDLLRPWKRVRPWLGDSSPVARDLEAIQRHVEKHIERWRAITANARTPFKRGSSSAKDKATGSESGKGAQAQYNDLARSFATGPDISPDTLLASIASIAELKASCAYTLKPGFAWSVAFQALCHIKAGAQGSVAVTADFAEVMSIPASTNRVLEQSRLALTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUM8</accession>
    <name>A0A4Q9PUM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_498034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="195" mass="21687" checksum="8943EB798F36A628" modified="2019-07-31" version="1">MSGHGATGGQTGRSRGGPWSSPEDAGLSQAAHPAHHDLIQHSHIRIPRCTFRRLGHVGGIGVAYYVCFVDSRGQIERQQRLTTCPFWHTNRLVRCGRQPSGRFLREQLSRRTSIGHDVQGRKHAIFVPCVGEPKVVLFLGERVRPDHQRLTRLAGSSFTCKSKAPGVQREIKFPEARVRASSSPSVGSNLVRWRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUZ4</accession>
    <name>A0A4Q9PUZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_906653</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14088" checksum="31684E78E654AB1B" modified="2019-07-31" version="1" fragment="single">VTNVSIFDLAAWYAHCGLSAASIALMQPMAVRMRQYYERRDPNSAEAFLQWPRTMAEVTAVPALAELALQVAALQENPDATTGHATAPLPLVIEGVDVDETMGEAQGIGEGQADEPGPSGTVLSTDAPGPSPPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVC7</accession>
    <name>A0A4Q9PVC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6313" checksum="DE333EFDA2B7CCAB" modified="2019-07-31" version="1">MFLCITPWSHHWLSLAGVATLSHAMLVSYVDITGAAVQMRSERCGMQQLMPIALPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVJ1</accession>
    <name>A0A4Q9PVJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_476873</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVJ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="98" mass="11338" checksum="ABB91EB0E8C5DC07" modified="2019-07-31" version="1">MVFRFASCCRTLSRCSPLSRCSPLSLFSVRYRIRSHNIVMCSSVCLAVLQPRALCSRLYPLCIPAFRAWRQCAHMIALILDCVLVFSLWNLPRSNRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXQ5</accession>
    <name>A0A4Q9PXQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_849572</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXQ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXQ5"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="8">
        <location>
            <begin position="407"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="606" mass="65302" checksum="4F312004EBC96D66" modified="2019-07-31" version="1">MDKCLKSGDGGLYAELLQNRAFQQVTPNTTAALNAWHPLGDAQLTVIADPKPVSNALPNSLQLIVPSGSTGSVGFTNEGFWGIKVDSSWTYKASFYYRFPASSSFSGPLTVGLRTNAGTVLAQATAQIRGTTSWQQITLDLKPTSSAPDINNSFFISVDGPKAAGQTIHFAMLSLFPPTFKNRPNGLRIDIAETLAEMGPAFFRFPGGNNLGQTPATRWQWNATVGSLLDRPGRVGDWGYVNTDGLGLLEFLQFFEDVGMEPIMAVWSGYALGDTSEPESALAPFIQQAKDQINFVIGDPAKSAPAALRASLGHPEPFNLRFVEVGNEDFIGSAPSTYPYRWRDFFGNLSAEFPNLRFIATSDVGSPVLSPAPPSYDVHVYQTPSWFYQNAFYYDSFERDGTTYFEGEYAAISTNSGDIFGTPADGRLSWPTVQSSSGEAAFMTGLERNSDIVFAASYAPLLQHVNSTQWTPDLISFDAGSVIKSTSFYVQKLFATNRGDQYLPSTLPTNGGTLHWSVTRSSSSGETFIKVANAGNASASITFDMSQFSTVASSGTLQLLTGLETASNTPEAPQTILPETSTISTGKSFTYNASAFSVSVITTTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY21</accession>
    <name>A0A4Q9PY21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_925143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY21"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11272" checksum="9E5DF161A9758E95" modified="2019-07-31" version="1" fragment="single">MLAWCVAILQAQDIMPRVAAGSGLGNKAKAGATSPPIYGLRRSMTLGEEDRKPVKLEPGSGAGFGFVHAEVIELSSDEEDRPVVKREVGSRTAMQHDPGDVIDLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q087</accession>
    <name>A0A4Q9Q087_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_321725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q087"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="310"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="385" mass="41676" checksum="49AF3A793E1F893F" modified="2019-07-31" version="1">MVKSKKSSPAKKRKSSSPRKPGARKNTTPGKPTGQHMAHAFLCRNGSGSFTLGHAVSCMEQTRADIGIETTRPKTTRNCYEGTIYSFEHNGKLVTRPFVDGEPKFKPAPLVATAVKEIRRTLPPDAHPTLLGQAMVKRVGAAKSPTKNQLFLERIRARDARPSMPGTPSNGERGASLAPTDISDVVMEELDDSMDFAPDDFVPSEGPSRPQPTAPPRTPVRLQATLSYLSPPQTTAQLPREASHARFPQPDFTAGDDLPFGGAGISPAETADKGPSDLAASSSWGPSTASGRTAIEALANDAKKLVDRICEEAQRSNAALQERDVRLQQQGVQLREKHAELQATNAALAAHRERSERLKDHLDEVIVAQRLQEPSTLPEQRVRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0T7</accession>
    <name>A0A4Q9Q0T7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caspase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_922049</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0T7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="47"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="306"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="425" mass="47928" checksum="5511FA4B5A96B6F2" modified="2019-07-31" version="1">MPTIPILRRFTAPWNHFQPQGKVLLKRFHTQLKGNDRQDAVVRKNPKKALIIGIGYEKGSGIDKLPNAHRDAKMWSELLKRKYGFDKRHIVMMLDDGQDPWLQPTKAKILREIEHLVQGVEAGDELVFYYSGHTGQVETDDTDEDDGLNEVLIPLDHEGYIEPGNMDKLIVDNDLRTMLVDKLPIGSKLTAVFDSCHSGTLLDLDHYLCNEVYQPFLCRTPSQQKSRWMAVKRKDACDVSADWEVREGQAVPRPVVRGSTGSREGTRIHQRLRESSEKISCVDTSLTRLPNGDKGERRFQLYTSEHTSTHTAQRANSPVTPSAHHVGTTEQTARTDTRQSEQATRTTKRASVQIRQTSGQTETTEWTKRTASRQNSLTSVMSYLGLRRTTSPEPMPDRLCVSGKCAITSLPITDVVGVAHRIATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1K6</accession>
    <name>A0A4Q9Q1K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">OHCU decarboxylase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_921827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1K6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3330.10">
        <property type="entry name" value="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018020">
        <property type="entry name" value="OHCU_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036778">
        <property type="entry name" value="OHCU_decarboxylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37987:SF1">
        <property type="entry name" value="OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09349">
        <property type="entry name" value="OHCU_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158694">
        <property type="entry name" value="UraD-Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="228" mass="24488" checksum="18301E929D8250B7" modified="2019-07-31" version="1">MPPAIRSWIHSVRPLGNFGAQTPSGTEDASLPPFIEAIADTSGTKDGPLAKALALLFEASSVLYNALVPGVAAHIPNAPPILSYYALIDVSLSVISSWNDELKAQFIAGHPRIGEVNGLSKLSEQEQAAKATAPEVLARLAHLNALYERKYPGLVYITFVNGRSRAAIKEELEDKLGLEHSVSVDEPLVESIVSVEAGSEEWKRELERAVGDVGKIAKSRLRSLGVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1T8</accession>
    <name>A0A4Q9Q1T8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">NCS cytosine-purine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_846507</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1T8"/>
    <dbReference type="OMA" id="ARWGWET"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="328"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="498" mass="54961" checksum="E71A7580A19D283C" modified="2019-07-31" version="1">MADDHKFPVADVEKDSSSVHDYTYAQRDWHYSHRWTRRALQWGLETRGITPVAERERIDTQYSKIFFIWLSANFNILSFSAGTLGPVIFGLGLRDSCLVILFFNLLCSALPAYLSTWGPKLGLRQMCQARYSFGYFGVIVPSVFNCCSMMGFCILNCILGGQTLASITDGRLSWSVGIVVVAVISLLVSFCGYRVLNWYERLAWVPVLVVYLVALGVGGKHIRNPPPAEPATAQAILSFAGTIAGFVITYASLGSDFTIYYTPSVPSWTIFLYSYLGFNIPIILLQCLGAAVVLSAPSVPAWNEGYANGNVGGLIEAMLQPTGNFGKFLTVLMALSVTANIAPTFYSFSLSFQVFIPPLAVIPRYMFSILATAILIPISIVGAHKFYDTLTNFLGLIGYWASAFGAVVLVEHLLIRRGDFASYDLHYWNDWRRLPTGLAALGACLLSCALIIPSMDQVWFVGPIAQRTGDIGFELAFASAGLFYVPLRYLELRFRPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2D1</accession>
    <name>A0A4Q9Q2D1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_814914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2D1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="100" mass="11091" checksum="B734C31697CEB915" modified="2019-07-31" version="1">MSIPKKLLPLFNVYRIGGRARVAVPWCAFEKGLRALEFDVRKGEGRERRVVAPATMGSGRATLYQPEDGIIAPHAQPHIVRVLSTRCGLTAEYLQKFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q371</accession>
    <name>A0A4Q9Q371_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor RSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Pre-mRNA-splicing factor rse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_920585</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing and cell cycle control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the RSE1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q371"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q371"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000628">
        <property type="entry name" value="Pre-mRNA-splicing factor RSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000068">
        <property type="entry name" value="Pre-mRNA-splicing factor rse1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="12">
        <location>
            <begin position="13"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="13">
        <location>
            <begin position="460"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="11">
        <location>
            <begin position="858"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00055157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU61717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1213" mass="133852" checksum="ED8560A7FAABB676" modified="2019-07-31" version="1">MHLYNLTLQPPTAITHAVAGNFSGSRTQEIVVSRGTRLELLRPDVQSGKVATVIASDVFGSIRSLAAFRLTGGTKDYVIVGSDSGRIVILDYDPKTSSFVKVHQETFGKSGARRIVPGQYLATDPKGRSVMIAAMEKAKLVYILNRDAAANLTISSPLEAHKNNAIIHHIVGLDVGFENPTFAALEVDYSESDQDPSGEAFNNAEKMLTYYELDLGLNHVVRKWSEPTDPRANLLVQVPGGQLATSDRYDGPSGVLVCCEDHIIYRHMDAPQHRVPIPRRRHPLEDPERGLIITAAVMHKMKGAFFFLLQSEEGDLYKVTIEHEEQDVKALKIKYFDTVPVASGLCILKSGFLFVASEFGNHYFYQFQKLGDDDNEPEFSSGDYPSYGMADPTAALPRAYFRPRALDNLTLVDELESLCPILDSKVMNLLPNSDTPQIFAACGRGARSTFRTLRHGLEVEEVVSSDLPGIPNAVWTTKLKEDDPYDSYIILSFVNGTLVLCIGETIEEVQDTGFLSSAPTLAVQQIGADALLQVHPHGIRHVLSDRRVNEWRVPSGKTIVCATTNKRQVVVALSSAELVYFELDLDGQLNEYQDRKAMGSTVLALSIAEVPEGRQRTPYLAVGCEDQTVRIVSLDPESTLETISLQALTAPPSAICIADMLDAGINKTQPTTFVNIGLQNGVLLRTVLDPVNGQLTDTRTRFLGTRPIRLLRVNIQRNPAILALSSRPWLNYTHQNFMHFTPLIFENLDYAWSFSAELCQEGLIGISGSLLRIFQIPKLGTKLKQDSIPLSYTPRKFIPHPHNGLLYLIEGDHRVMSEEAAAKQLQQLRESGRAVDEEMVNLPPEQFGRPKAPAGTWASCIRIISPLDAQTVNVIHLDNNEAAFSLAIVPFAAKNNELHLVVGTAQDTFLAPRSCTSGFLRTYRFTDDGRNLELLHKTETNDVPLAIMAFQGKLVAGVGKALRLYDIGKKKLLRKVENKTLGSTIVTLNTQGSRIIIGDMQESVFYAVYKPPENRLLVFADDVQPRWVTATTMLDYNTVVASDRFGNVFVNRLDAKISDQIDDDPTGAGILHEKGVLFGAPHKTAMLAHFHVGDIVTSLNKISLVAGGREVILYTCLHGTIGILVPFVSKEDVDLLTTLEQHMRTEQLSLVGRDHLAWRGYYVPVKAVVDGDLCESFAKLPANKQSSIAGELDRTVGEVLKKLEQLRVTASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4K5</accession>
    <name>A0A4Q9Q4K5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD310DRAFT_871729</name>
        <name evidence="20" type="ORF">BD311DRAFT_694620</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 464.89</strain>
            <strain evidence="20">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="ML143420">
        <property type="protein sequence ID" value="TBU28649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4K5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4K5"/>
    <dbReference type="OMA" id="HAENMHR"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028840">
        <property type="entry name" value="Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU28649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU62267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="430" mass="47046" checksum="4C411DB6C5600C58" modified="2019-07-31" version="1">MLARSNARRLPALVIRSLSTESATSSGPQPPPPPPPSAGKHPTAKSASRSRLNPAPRPTVAHRSQVLAHLPPSFGRNQILPVADSTRALLESIVARFDAPIRYAFAYGSGVFEQDGYKSSNPQSQDGPMLDFMFAVTHPDHWHSINMNQFPGHYPLGARTLGSSFVARVEEIPPGVWFNSMVKMDGVTIKYGVTTVDNLCSDLLNWKSLYLSGRMHKPIRIIKDDARVRLTQQVNLTSALRTALLTLPAEFSERELFERIAGFSYAGDVRMLLPAENRGKVGNIVRKQSPQFKELYHRLVVALPGVHWPAHSATIQQDTSPQARAAHLRKLPSNLLKHLTDHYTGQASIPAKEADETVYWAKLAGDASLPSVIDRELTKIVRGPSAIQTLKGIVSAGPVKSVRYAAEKVNKWWKGSQGSSSPSSDAGSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4S4</accession>
    <name>A0A4Q9Q4S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_871915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4S4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.30">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024047">
        <property type="entry name" value="MM3350-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159941">
        <property type="entry name" value="MM3350-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="380" mass="43871" checksum="8D9AD04B2793F6A2" modified="2019-07-31" version="1">MSNTGVLDGNNVNQLHTAPNQAHGPQPGSSKRALEEAALSLEESPAAKRRRPQPDLSTLLPPPSNCEIQLRFQLCRFQGVYRVVRVPFTFTFAHLYRLILLLFGWSGYHGHQAEVLTHVEKYASPGRKGEVKKHRYWKVPPRPARGEEGWVEWYQDYSRHEREPALRVAPKGRKSLGWDFEPHFDEDYEPMSRWERLWKELQVPWKKDDEVTLGDIWAPKSRDNFTNGECSNEEIAIHLEYDLSSSWDVHVTIEADKDGHYMWKVNPPTNRPVITVATGGAPVEDARSDRGELDGKKKKVSNMLFLPDIFERFLKGEVGSEARKTEHAVYDMEEERARQQAAAEERERQRRERQQNQTNGPGDDGEEHHSDGDSYSDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q541</accession>
    <name>A0A4Q9Q541_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_919271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q541"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="16"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="369"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="85"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU62369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="423" mass="46737" checksum="56126101E3812D68" modified="2019-07-31" version="1">MLRGALRTPAVSLQTPLWYPSPARSTLRYLRPTSRHYSTPTQTPENKRESSPDNGSLPSAEPSYREDATATGGEPIAMPPPPSGSPSSSSETGSSKNGSAGSTEQPNSIQDRMRELSTGALKEMRVRGDEFTARVARTFSKLGAELNRVTGYEEIEQLKRKVVEQESRIHHAREAARAAKEAYDSAVLQRAKSQREVNDLLQRKSHWTDEDVSRFTTLVREDHAREHDEARAKAAAYAAEDAVEREFSALMRVILNRYHEEQAWSDKIRSASTYGQLAALALNLAVFVLAIVLVEPWKRRRLAQTFERKVEEMGARTEQAFEDKTSELKGRMDEQARVLAAVLETVHLANQVDVGELVALQRGVGLGPADDNEEAQPALSHPHGERISGALPKPRTDGEMVLVMTASAAAAGLFGWLARSWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6B3</accession>
    <name>A0A4Q9Q6B3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_974094</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6B3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="391" mass="42759" checksum="4ABF078239D044D1" modified="2019-07-31" version="1">MAPIRGETDSKLAEPTYTEEFVQNEDGDFIVRFKCRTCGTTVSRKADVDRHINDKHRPPKYFCDVPGCKRVIVGFTQESNLNNHKSSVHLNLALYQCPHHWVDPHNGRIFPCRAKYKDRSSLSKHRKDKHGFKTGDDDAKVARPTPFGKRFPDSKGVSRASTSLSIAGRSSAPYIVPPPSDRRSSRMKVSKTAVIKQGQEENDTTALQPGAVGWSSHPQPVKVAGWHTGSSSGQHREEARINDYLKDPGFIALYEALCAQFAFRASEALQIPTQVGAAADHYWTVDSQSPALGCHVAGAAFNGLTAPTGPNLPDPSGTTAFEQTNMLNAGSGPFPVHNGHTPNTWLWDESVFADSSASGELPSFLEDAFSTGPSQWMSTSTLDNPENHVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6X0</accession>
    <name>A0A4Q9Q6X0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6X0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6592" checksum="342408F92711A26A" modified="2019-07-31" version="1">MGSASSPLRHGPHKSSCRRSPSCPSVHRAHIERRKRATIVVTVCLFVNPIYTHSRVTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7C2</accession>
    <name>A0A4Q9Q7C2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_917317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7C2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7C2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="466" mass="51351" checksum="1F3883F0F0ADBB11" modified="2019-07-31" version="1">MTWTRNRRLVNALKLERFAKPRTSLRSMGVSMVANLSPFVPRRCYASGPESSVTEVEKILLDTIKATGPITFATYMQMCLSHPTAGYYMNHRNPVLGPQGDFITSPEISQVFGELLAVWLLSQWLSAGASRQIRFVELGPGRGTLMHDVLRVFSQYSFSRPAVKEVHLVETSRPMRAAQEAKLGPIAQKNGWSLHWHDSVDDVTPDAEMFTLVLAHEFFDALPFHLLQKIEKGWREVLIASGPDPAAGTILKSDGSPSLDVSTTRPLVSTAARFRQVLSPTPMPTSTLLGLSSPRFQKLPAGSRIEVSPAAFKISRKIGGLLHDKHPGGVRSAGSALIVDYGGSKVYGNSFRAFKNHKIVDIFHRPGECDLTVNVDFSYLAEAAADLATSHGPISQADFLLRMGMSARVSALQASAKDDYRKKQIQAAAERLVDRTGMGAQYQVMALTGKRTTEVEEREKWPFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7F4</accession>
    <name>A0A4Q9Q7F4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_841449</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7F4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7F4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19690" checksum="50BF8B48A14D4B2F" modified="2019-07-31" version="1">MATLTVADLLARNKASLASYQPRPYLSDRAALNIPPPSSVLVTCCDPRVHPEEFFGHKSGDAAVLRNAGGRVRLSLIDIITLDALLGHGTLKQLLIMHHTDCGATHFKDEDLKADTIARHPERRAEIEAWPPISFHDKTIAESVKEDIEAAQQSELLPEALKKGVRGFVLDIKTGVVTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q824</accession>
    <name>A0A4Q9Q824_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_945625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q824"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7355" checksum="B69370DFDE9B8242" modified="2019-07-31" version="1">MPIQEPQAQRRAVANVHRAKMTVGNANASARMSRAQPRLKPTQLARHWPARGQIPPHTAQRKARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8K9</accession>
    <name>A0A4Q9Q8K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Caspase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_659856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8K9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="5">
        <location>
            <begin position="172"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU62944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="481" mass="51363" checksum="C30007202268B664" modified="2019-07-31" version="1">MWNNYPGQQGGYPPPPGPPPPGAPGFGFPNPNLPSPSPGYNPGYAPAYGGPPGGYTPPPGPPPPGGHHHHHHHQHHQGGGFMPPPGPPPGYGGPSPGYGGPPPIPGGRPDGGGYGPPSGRSPAPPSSYGDYQPPAGPPPPPPSHQQQYGPTFTGQDNQQHQLFYQYSQCTGKKKALCVGINYFGQSAELKGCINDARNVTRFLQELYGYREEDIVLLTDDAQNPRQIPTRDNIIQAMQWLVRNAQPNDSLFFHYSGHGGQTKDLDGDEADGYDEVIYPVDFKQAGHLVDDTMHEIMVRPLPPGCRLTAIFDSCHSGSVLDLPYIYSTEGKIKEPNLAAEAGQGLLSAVTSYARGDMGGVFSSVTGLLKTATGGTQRAEQKTRATKTSPADVISWSGCKDSQTSADTFEAGQSTGAMSYAFMTCLRQNRQQSYQQLLTNIRAILKQKYSQKPQLSSSHPMVGAALANVALSIGDADVLFRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAS3</accession>
    <name>A0A4Q9QAS3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_943715</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAS3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAS3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="57"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="387"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU64709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="630" mass="69930" checksum="C0947CBA136586E8" modified="2019-07-31" version="1">MAPKQPCAKYQYVVTSSGPKIVPVPDAYSKDEEAPADYNTGGYLQVKIRDTFKDGRYLVLRKLGWGHFSTVWLVKDNHTRKHSALKVVKSAGRYAETARDEIKLLRQVMDANISHPGRHHVVSFLDHFEHPTPDDNHICLVFEPLGENLLALIERHKKTGVAVDLVRVIAKQLLLGLQYLHDECDLVHTDIKPENILISIPDVEAHIQDELSRSPSPTSRKVVVPPKQLTRASVAIPRHKSTRERQVEIFDSQPLSSPSSYSCPNSPARLSYITRVASAQSASASIPSSFRRMNDVRRKSVTKLALTTGPFAESTSSTPDGSDSSRSGCSSSAYDSVMVSSSVATSLSNDTPPTSVASVTSAVDKMRFTSAEKAKEDNCTCTCGVESAAEDDERRPERPTRPAAGPSLLTQTAPRDLATSTSSICSQHSTSSRPSADAHSECSQDPTPMPPPLPISIKIADLGNATPTHKHFTEDIQTRQYRSPEAIVGRTDWGATADIWSVACVVFELLTAEYLFDPQSQGDLFGKDDDHIAQIIELLGEYGETKWNGRFSRDLFDSSGSLRYIRSLKPWPLKRVMVEKYLWSEKDAEALCSFLEPMLTIDHRERKHARDMVDHPWLEVDPLSEDLWGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB08</accession>
    <name>A0A4Q9QB08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">TPT-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_914429</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB08"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB08"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="477" mass="52899" checksum="AE7D68DC929CEC22" modified="2019-07-31" version="1">MPNSSHVANGPARFSSLRHALLRGSPTSREPPVHVASLAEKKRLWWTNAFINGLFIAGWFFFATLLSVYNKWMFSPDRYGFPSPLFVTTAHMWVQFALASLLRYTLPRHFRPEQIPTREDYIRKVVPTGITTGLDIGLSNLSLKLITLSFYTMGKSSSLVFVLLFAFLLRLEKFSWRLIGVIFLICAGVLLMVATQTNFVLGGFLLVIFASALGGLRWSLTQLLLRSKNIGMNNPAATLFWLTPIMGLTLAISSAVSGDWGKVSGSDFFATPGKAFETAFFLTCPGVLAFCMVLSEFYIIQRAGVVPMSIAGIAKEVTTIICAAWFFGDELTPLNITGVAITACGIGLYTYHKYQNLMHSDVALDPHGNPLSEEDGVIVDGDVALESGDLAERERLTSNVDDEDVNDEDERQNRVVNAAHDANEQLLFAVEDEEEDEDEDTPSKHRQRLDSVPPPYPGNESDVLHDVWRGHEDIHTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBQ8</accession>
    <name>A0A4Q9QBQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DCP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_805669</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBQ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBQ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="122"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="668" mass="73177" checksum="81ACAAE762C76361" modified="2019-07-31" version="1">MASSSSSSPELYAAAQASSSHEHAYATVQYSDLSRDEVLEDLSSRFILNLPEEELASVERVCFQVEQAHWYYEDFIREQNPSKFPSYTLKTFSEALFRACPLLAHWAEDHDRSFEQFMKYKTRVPVCGAIMLNDTWDKVVLVKGWKSSAGWGFPKGKINEQEPKHRCAIREVLEETGYDLEEQLDPDNVLQMSIKEQSISLYIVPGVPEDYPFKTRTRKEISKISWFRLSELPTWKRGRTVPGKFYLISPFIGPLKAFIHDRKPHHLPRKIPKPPVQNVKEEIQSSSEEDGAAAQDQNAQELSSQASSAEPHTPSPQYSAARVHDSTFESSISTATPDPARQADPIPLNTGDSHLAVLLSGLMRSAASVTLDDTGKPQTPPVEVLPVPVPASHRQALPAQPCESPDWSAHAPAKMSAPIVQLPSTVSAAIPPPQSPGRTPLQSSSSGTSSATSPSLGTVGGGHARRGSTADISPYLSHSRNIAKEMRYISILESVAQESDRATSRMGHRSPMAAPSQPAYVPLQPPSVPPPTIDQSVIYSSPTPHMPRSQDLHSAYRGQAPDVFMNRPQTSHAYHLPPFVPAAIPRQSMNEHQLRAMLPLSGPCHGSASSFAPPPMYPALLQAPTSPLRTVPPPHYAAPHIAHNNAVRATNNAQLLSILNAPSPGYRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCR3</accession>
    <name>A0A4Q9QCR3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_911605</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCR3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCR3"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="402"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU65572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="459" mass="51585" checksum="7E1D7538B3DEF3D6" modified="2019-07-31" version="1">MSLYSDHILRHVPSFSRILVASSILRIALIIYSEWHDAHSIVKYTDVDYRVFSDAARFMLHPSPDNRAEGPLAAYFNFGSPYTRATYRYTPLLAVLLAPNEWVHPSFGKFLFAAADIVAGVLMHNLLLSIVLPDGSRIPQKNVTENASSGAADAKNREEALRRRATFLVSLHLLNPLVFTISTRGSSESVLSLFVLATLYYALKGNWDLSAVLLGLSTHWKIYPFIYGVACLGVIGREHGAGGGLTGYLRSILNRGTARFGLISGMTFLACGVAMYAIWGQPFLEESYLYHLHRLDHRHNFSPYFYLVYLTYPSAQDGLSLEASSWKRLLRSPLTSFIPQMVLALGTGLLFGRRKEDLVFTWTVQTFVFVVFNKVCTSQYFLWYTLFLPLLLPRLSMSGRRALAYGAVWIGTQALWLSEAYKLEFLGQNVFFGLWARGLVYVVGNCWVLAGIIDSYTES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD98</accession>
    <name>A0A4Q9QD98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_282003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD98"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12465" checksum="FADA5D3021D2667E" modified="2019-07-31" version="1">MLLGRLSAYTTLFVIPPVTPFYETCLLPPPDTQSKLNALTVCKQYGRPQLSVRRLMLDRWPSLNMAGLWPHRSSLGGVGPRALTLMLSELRLIPACCAARSLAIGLLPAHGMPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDN4</accession>
    <name>A0A4Q9QDN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_910990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for vacuolar assembly and vacuolar traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the VPS41 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDN4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDN4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000350">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 41 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016902">
        <property type="entry name" value="Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028921">
        <property type="entry name" value="VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="145"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="8">
        <location>
            <begin position="720"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="943"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1027" mass="114938" checksum="E7429E11A7F5B29D" modified="2019-07-31" version="1">MSAEPNDPALEHQNGNLSQEQRAGLISASPDNMTEASDEDEHNEEVKSHENGEAHVENENETEESEGEESEEEATDEEEEDEGEEDDDDDDEPALKYERLGGIAHQLLQKDSASALAYSNQHLALGTHGGKLHVLDLAGQPVKSFAAHTASILDISMDSTGDWIATASIDGQVAVYSLSNPETYVFNMKRPLRTVALEPSFAKSSTRSVVSGGMAGNLVLHEKGWLGYKETILHSGEGPVWQVRWRDNLIAWANDLGVKIYDTHSQSRITFIDRPADSPRADLFKCTLHWQDENTLLIGWADHIKVARVRARPRKSSGSNLPPLLVEITAVFQLDCMISGIVPHLMTRSPSSVQTHDALVKNGSVRSTVSPILTSFLILAYTPPDTSLLTGNEATADRAEQARKLAERPELRIISRSGEELSADALGISGYERWGCNDYVLVDIEAAPAKGPPGAAQGGERYYIVCSPRDIVVVKPRDWRDHVAWLVERKRYEEALDVIERMGHEEPGVTKAEKDELDAVQIGQRYVEHLVGEGDFVKAARLCPKVCGHDTKRWEDWIFVFAQKHQLQAIIPFVPTESPTLGHLVYEMILAHFLQHDRQTLLQTIKTWPKGIYDISAVIVAVQSELDRAPSSSSKKPDGPDTVILMECLAELYTLNRQPGKALPYFLRLRRPNVFDLIRENNLFTDVQDQALLLVEFDQELREKRKKDGEDIDTDPTAAITLLVDHIHSIPMTRVVQQLQNRPYYLYLYLNALFQKDPHLTSSYADTQVKLYAEYAPRKLIDFLRASQYYSLEEAYKVCNERDLVLEMVFLLGRMGNNKKALHLIIERLGDVNRAIDFAKEQHDDDLWEDLLRYSETRPAFIRGLLENVGAEIDPIRLIRRIKNGLEIPGLKGALIKILHDFNLQVSLLEGCQTIMNGDCADLARKLHRNQTSGFFLSAKTPCPICNKPIGQGLNSLALLFLCRHVVHADCVQHDEELPHQLDPTLVGMGIGGQPGLSGKVAFTAILRARITQGCPVCHKRSEGQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEH7</accession>
    <name>A0A4Q9QEH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_805419</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEH7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEH7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="114"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="699" mass="77310" checksum="78C1238069A4142E" modified="2019-07-31" version="1">MDDEGYPSNAPLHVLVHWFVRPNELPKHRVQREFCENEVLYHISGTAVIPAFYILNSCTVSSSSASAIRTSTTVSSVAKVSHTSFFCRLAVDPQRGLYYELNWDALRESALKTVPSEDNHLEHDESATVAWPNTRRGDGASPRKRRRLSRTAIDHASDSDPDAEGSEDEFQASHASVDEDEDGSGGEPSEDEAEDDHDSLAPDEPRTPSRRGRGKRKRAPTTPRTPRTPKTPRRPRADRVTLAQPTPHSKAALRRRKKTALAVRPPPPAEGTLELALSNGLEGDAWERAMHVLHVAARPGALPCREQEYGRVLRAVEELLEEGSGGCIYISGVPGTGKTATVHAVVRELKRMAEQNEANPFAYVEINGLKIPEPNAAYGLLWEAVCGHDAARDGHMKISAKEALRNLSKHFSNASREQVGPTGSHACVVLMDELDQLMTTKQDVVYNFFNWPTLAGSKLVVLAVANTMDLPERVMTGRVRSRLGMVRINFQPYTTPQLESIVKARLLASKTAHPPLPPNTPDVLAPDALKFAAMKVASISGDARRVLDICRRTVELVHPLRKPARTEDVKAVIKEMQNSPTAAYLRELAFHERLLLASLLKCVRREGVEEIKWADVQNQHRIYLNLLADDDPSRRPSPDELLLVFDALLASHALIAEEGAAVARKPEGERRIALNLEYAEVERVLGEVGGPKWRNALNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K0Q2</accession>
    <name>A0A4V2K0Q2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptide hydrolase</fullName>
            <ecNumber evidence="7">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_1040681</name>
        <name evidence="9" type="ORF">BD311DRAFT_787697</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="7"/>
    <dbReference type="EMBL" id="ML143411">
        <property type="protein sequence ID" value="TBU29753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K0Q2"/>
    <dbReference type="OrthoDB" id="10013407at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF26">
        <property type="entry name" value="PEPTIDASE M28 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041009097" description="Peptide hydrolase" evidence="7">
        <location>
            <begin position="25"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="8">
        <location>
            <begin position="253"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU29753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="468" mass="50949" checksum="3BF1FA02BEE36212" modified="2019-07-31" version="1">MLLNPIVPLALLLVAPYTPEVSESCLSQYYYGTHGQQNVFITGDDDCLAEATLHLTSGAAVQLTEDVQQLVWLQHQAVDHSIKPATFRDEFDVFFSRLSVPPAEVSDSEQTVFSNQNAAKLLYRTESSALISVDPATALTLDLHLPRFWKASPLPSSPVPFIPVPSEAVERVKKILHGLKFDPVVASIVSNISVPQLRADVRYLSGESPQSEIVSRHSFSKGVLIAADWLKANFEAHGASCTLKPFLSGFAPNVVCLYEGSENTTETVLISAHYDSRGSFGSVRAPGGDDDGSGTTALLGIARVIARKGLKFRKNVQLVAFAGEEQGLYGSRYYARELYEKGANLTLMVQADMLGYHAAGEPPQLGLPDVIGTREVTQLVANLSAIYSPELKVGFTPACCSDHQSFHTNGFPATQVFERAGPIVDPMYHNSGDLSDREGYDFEQIKSIAKVQFATLLHTAGFDLPEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K2F5</accession>
    <name>A0A4V2K2F5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929271</name>
        <name evidence="2" type="ORF">BD311DRAFT_650807</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K2F5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7213" checksum="9E83CA3327C5B003" modified="2019-07-31" version="1">MSVQLGYTVNVVNDESGRCKGNCPILQSQHGSDAGPLTHNYSGKGANSPTTSSPMLGVICDRTALGKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K778</accession>
    <name>A0A4V2K778_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_934540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K778"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="EF-hand" evidence="8">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="992"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1083"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="1196"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU55048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1233" mass="140670" checksum="79418EB69A841ED7" modified="2019-07-31" version="1">MPLFSRRPKTPKSRSTSQSPGPASRIPKPDEPPPALPPIHFPKPLNGNTEDLDMAKQLDGAFQAIGDAGEDVQDYKGSRSLKVLNITSTAVNSIQTNVASAQSYSSPMKTVYESDAMKTIREGVNTLVDSLPGIVKALDEVAKIHPFIGIAVGAFRVVVELDMKRRDNDKKIGVLFVEMRDLMEALLQLRGIKDEESVGPDGQTIKARLQELVKQIAEDIKTCANACDTYAKKKLIVKVIKGSIWDGTLSGFIDLFAKRRKAVTFALSIHIGVGVDDANRRLKAIDAKIDMVLDFFSKAISPEQLELAALVQKKGGPTVVMADNVALKELMKFRPAVASDQTKQGTGKDVGEHNSHSEGDDLAVVKQELFDSPELAIKKNLEVFERKFKMQQRELAEEMRRMVHHEGDRVIEAITSGPHDRIIDPDIHEIWKDMRWPGHVKARHFVLALRDFYRQQAEKKRKTHAHGEAPVSRVADKDEWALEWININRLQAIAEAFDDDASGFITIAEVNQFTASRPKGWSLPHWLAYWAIGWQMTATKYRDMMVEIFAKMFAIRPQVHPANRNAVDKYLRTVWRKLSTLTSSLVTTYQSDALQERFKSYVEEEEQRLREGLETVKYDIDAMDTLLLTTGPGRIEKYLFPLLWLLLHRDFEIFRLCRTTVIHKDELWDSADTIVWVFDAITDRHNDLLASFKQQKLDATEQFKVFASELFDYWHDSEKFWSLDNLRTLEFMEVEYDDSKEDQDVDVNKLLNYPSAGADLYPPCVEDPITENDAAADDAVRLILGRWNGFLISEGDIITSMYTFCFHASMDHKTYEASANGANGTDYNLIGDYTTKDDGTVEYNISRSYIARFRKSYWTGRLEDDGETLSGRWGYEKDDQPYTFLFKRVPPEVLVDRPHPKEFKENRIRALWKYALTVVRNDVRRKMFSWSYIKERRDLRLEYLKLAQKEEEGILTSEDVERFGVLDQRSTFNDVRCFYVLQDIRQRSVIEHFGVICDHCGEPILGTRIVCMECGSRFTFDFCDKLACVGCTIKTRDDFTTPHLPTHDFVKIRTAILHYREIGKVLRSAKAGLERAKRLLEEAKQRKDEESEEDDKDEPTNLPETKVVPAPLRRVTTTMSTDSASEGEVVVPRCIKCAAVVSMPCLYCIDCPETVNAFICSECDEQHAGFFHDEHHLATHNLVVCKTQDDSTSDETSKAQERLAALESKMSELTSQLDRMEKLLQSFAIVRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8H9</accession>
    <name>A0A4V2K8H9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8H9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10947" checksum="517E5BD1313C2EFF" modified="2019-07-31" version="1">MYLALLLDTIYFSLDKMRIYVCYVQVATSSQVRDTILVHDPDSTERCTPRDQAPGVNTIAELEKQIAEEQARLETRSHDKHDKSTAQLQIASAGSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8I0</accession>
    <name>A0A4V2K8I0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_905538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8I0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="57859" checksum="210F58ADD2E29B59" modified="2019-07-31" version="1">MSSPTAALFTSTLTYTLSPYEPRSASGLATKTDLRSSVYPVPPDRSSTSTGVLGNAPLEIFREVLAILRQEEAQKALSSCSRACKSWNEVVRPYLFASIVVRRKTTFAGFATFLQSDVACITRHIQSLVLSRPLRRSVIIRRETYGSWLAQEGAENPDITQAQWDSFGGACVDCPQLDCDVLASILSHLPNLKRLTLHGLRLVLPDATRAMEATLLTRKLDYFELSEIWAVGDASLIPSLFTSLLLSSVRELVMEECGGTADAAADMMPSPSKRCQLQVNVEYLIMRGAFQLSLGKYGKFLDVRTLRSLSLHKSDWATSDLAESAWRFIRDRCKYLEEVDVDLEDVIQLGLRESQDDHYDEEQSPPTIWLRLGEALSSCKKLSRLCLRFALSKAKEYPEKRRPSSFRMFGSIFSGAGMPALSELQIQLEWKPDTEILAHIQTVELWDIGKLNEIESRRAGFPDLQRVAITCAVSGSTDEQCKALFGQRMERELIGLHEANKLSISFAIGEGRCIGEPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8Z5</accession>
    <name>A0A4V2K8Z5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hsp90 chaperone protein kinase-targeting subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_845059</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC37 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8Z5"/>
    <dbReference type="STRING" id="114155.A0A4V2K8Z5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.610">
        <property type="entry name" value="Cdc37, Hsp90 binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004918">
        <property type="entry name" value="Cdc37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013873">
        <property type="entry name" value="Cdc37_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013874">
        <property type="entry name" value="Cdc37_Hsp90-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038189">
        <property type="entry name" value="Cdc37_Hsp90-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013855">
        <property type="entry name" value="Cdc37_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800">
        <property type="entry name" value="CDC37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12800:SF4">
        <property type="entry name" value="HSP90 CO-CHAPERONE CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08564">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08565">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03234">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01069">
        <property type="entry name" value="CDC37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01070">
        <property type="entry name" value="CDC37_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01071">
        <property type="entry name" value="CDC37_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101391">
        <property type="entry name" value="Hsp90 co-chaperone CDC37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cdc37 N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 Hsp90 binding" evidence="8">
        <location>
            <begin position="182"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Cdc37 C-terminal" evidence="7">
        <location>
            <begin position="383"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="172"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="468"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="510" mass="56594" checksum="5FE97AD34A210FBD" modified="2019-07-31" version="1">MPLNYSKWDNLELSDDSDIEGHPNVDHRSLVRWKQRAIHEQREERKLRIAQLKADIGVNEVLRPRLAAIAQDVDSQGPPHFSSLVERFKTNPAPDKPPTNAPDQKTYDEMLLALMLQVWEEAKKKGVEKDDPKLGQALVEGLKTHLVRIDEHQEKLRKELAKEEAEMHKKITSEDIHEGFDSKYVPPKPAPPPVKNAIQDKPKKTVTEFETLNPRGVASAPSTSSSEASSSKAPARDDDPEADELPELTPSLEGFSRIPVRAYEQSWEFIKAHRDVYVPGASDALLVAAFRAQSDGNAKGALQCVHQSLLLQYCEKLGKDGPSMFFRKMTSGDPRATAVFEKDVQDTYAHLVERVRISKAEEAAASGEQIQLVPENPDTQIGFNVPDGPPPEHLELEGPGFENVSVEDVRKALQMQWDVFSAFDERLQKALRSQSLDEVNKVLGSMKVEDAEEVVRLLDVSGILNFSESGVRDETGRGEADEGGSTEEDGEGDEGGVEEEDGNSKVSEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Y3</accession>
    <name>A0A4V2K9Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ig-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9Y3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007110">
        <property type="entry name" value="Ig-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50835">
        <property type="entry name" value="IG_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ig-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10165" checksum="4A0C24CE5B713292" modified="2019-07-31" version="1">MTAGQKLAREISGMSECASDGRPWLSDRPNASWPRGGTIRADETIANSSLSLNFNDLLPHNTPYLSCEPTKSLPTESLSRRNSCPAAYCWLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Z6</accession>
    <name>A0A4V2K9Z6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_912128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9Z6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="16394" checksum="AE388CAD8CB3703B" modified="2019-07-31" version="1">MQRRLDHCFPSFTFMSQELQKDTLRLPSYRESVFFRFHPYPQARRRTVDPLMRKVDYRSVAEPVASACEESRVPEQEEQEKQEDEGEDAALYLDVVMNRVEEPHVKKRRSLTSLIIDLALAVTAARLSKSRRSAAKLGADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2KA31</accession>
    <name>A0A4V2KA31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Transketolase</fullName>
            <ecNumber evidence="4 15">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_912787</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="15">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="15">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="12">Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="4 15"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2KA31"/>
    <dbReference type="STRING" id="114155.A0A4V2KA31"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07033">
        <property type="entry name" value="TPP_PYR_DXS_TK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000003">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000004">
        <property type="entry name" value="Transketolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055152">
        <property type="entry name" value="Transketolase-like_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049557">
        <property type="entry name" value="Transketolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="TRANSKETOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522:SF2">
        <property type="entry name" value="TRANSKETOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22613">
        <property type="entry name" value="Transketolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 13 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="16">
        <location>
            <begin position="353"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="118"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="473"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="524"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="14">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR605478-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU66108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="678" mass="72701" checksum="3908FE891D26ABAF" modified="2019-07-31" version="1">MSQFAPESSDAIAIGTIRALAADIVGKANSGHPGAPMGLAPAAHVLFTRFFTANPKNSKWFNRDRFVLSNGCALQYTLLHLLGYKLSLDDLKQFRQLDSLTPGHPEAGHTDGIELTTGPLGQGISNAVGLAIAQAHLGATYNKDGFDLINNYTYVFAGDGCLMEGVASEAASLAGHLQLGNLIVVYISIDGDTAVAFTENVELRFQAYGWHTLHVDNGDSDLAGIYNAIAEAQKVKDKPTLIRLRTTIGYGSKQQGTHGVHGSPLKADDIQQLKTKFGLPADQSFYVPQETYDAYHAVASKGAKAEAAWNALLASYGQKYPKEHAELTRRIAGKLPDGWEKALPVYKPSDPAQASRKLSEIVLSAIVPVFPELVGGSADLTGSNLTRTKTMIDFQPESTGLGSYKGTYIRFGVREHGMGAIANGLHAYGGIIPFVATFLNFVSYAAGAVRLSALSGHQVIWVATHDSIGLGEDGPTHQPVETAAHFRALPNLDFWRPADGNETSAAYYSALTRKHTPSILSLSRQNLPNLEGSTLENALKGGYVVHEVQGEDLTIVSSGSEVSIALEAAVQLQSEGIKTRIVSLPCWSVFDQQPQEYRLSVLRSGAPILAVEALSTLGWAKYSHEQYGLTTFGASGPYKKVYEKFGLTGPNIAELGKKVVTFYKQKGGEVVSPLVKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWB2</accession>
    <name>A0A4V6MWB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1769-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_817458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWB2"/>
    <dbReference type="STRING" id="114155.A0A4V6MWB2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="3"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7918" evidence="3">
        <location>
            <begin position="329"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52812" checksum="05884135AF576997" modified="2019-07-31" version="1">MPRLRVLAGPSPDELFPIQANSGKPARISSDAFEGQVAVYIKGFADAEGRVTDSEYFKKRSGVTWSIQVQGRYLNGYNADELLFGNIFDRPLKLPWVFSAALRFMNFIDPTLENDLASRTRPWALSPLIATMPYFHHTRATDSGPAPSFPPPHAPINDDTSQLQTIPTATNSSGKGGKLKDSPSKRRSYFTNALRRQEVVFGPDDVVTTDFCYDFLQFSPDGIMLRLPGGISIEMTKYWDGQPVRFVCCERLNKSERTPERAWGRVLWCIVIEPAEGDEDSVGVGEKGKFSFEAFNITHALMLAGALRHASATMLHLGYEVWISDGRKERIPEYDVKYEGEDGKTIVCYIPSESGKEFQIRWKDHNGAYAPHASMKIFVDGHAVGKTRCPPGVAGKRLGISTTSADTYQPFQFANLQTTDDDDTLWGAGIPDKLGSIELHVVHVHAHVIQTAFRPAGFAGTGPVHERSKKAGAHCVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MIN3</accession>
    <name>A0A4Q9MIN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_935321</name>
        <name evidence="5" type="ORF">BD311DRAFT_696852</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143434">
        <property type="protein sequence ID" value="TBU27265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MIN3"/>
    <dbReference type="STRING" id="114155.A0A4Q9MIN3"/>
    <dbReference type="OMA" id="GPRYGRK"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000002">
        <property type="entry name" value="60S ribosomal protein L37a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00327">
        <property type="entry name" value="Ribosomal_eL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003058">
        <property type="entry name" value="PRK03976.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU27265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU54696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10229" checksum="AB036F4F9F316E46" modified="2019-07-31" version="1">MTKRTRKVGVTGKYGTRYGASLRKQVKKMEITQHARYTCTFCGKDSVKRQAVGIWKCNSCKKVIAGGAWTVSTTAAATVRSTVRRLREITEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MRJ0</accession>
    <name>A0A4Q9MRJ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_509152</name>
        <name evidence="7" type="ORF">BD311DRAFT_659073</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143406">
        <property type="protein sequence ID" value="TBU30389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MRJ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9MRJ0"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040684237" evidence="5">
        <location>
            <begin position="22"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="66"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU30389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU57898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="491" mass="52591" checksum="D03A8303BFEC9D2E" modified="2019-07-31" version="1">MRQSLATATFVFSSLLSLAVGESLQARSQYDSTCKEIEQAISSASALYWPGLGSYYKDIGHWATSSSAQAACSVEPGTAEDVGKILQILSANNTPFAVKGGGHASNPGFSSTEGVHIALYRFSSVTYNQAAQTADVGAGLIWDDVYSALEPYSVNIIGGRVTGVGIAGFTLGGGFSWKTNQYGLTVDNLTGFELVLPNGTVAEVTQSSHPDLFWGLKGGFNNFGIVTKFTLKTYAQTEVWGGIILVTEDHLDDLTAATLKFTQTVTDPKAAILPTYNFLIGEPGATVILFYDYPTAPEGIFDDFLAIPAFSKDIGTRTFLDLVLASPSNATSPARGIFHTVSLLKYSPAIMDALVNETKFWGERLSLKSGTFISYDVEPFLPDIFSHAPENSSAYPSSRSSSLLPLNIYYAYSDAGQDETFWDAARQSAAQLTAVAVADGQDVADAPLYGNYAIFDTPLERIYGQNVDALKALKAKYDPEGVMALAGGWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N8G1</accession>
    <name>A0A4Q9N8G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_944036</name>
        <name evidence="6" type="ORF">BD311DRAFT_648973</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N8G1"/>
    <dbReference type="STRING" id="114155.A0A4Q9N8G1"/>
    <dbReference type="OMA" id="ISRMTSM"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="62"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="409"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="625"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="744"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="893"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="683"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="893"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU35266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1040" mass="113358" checksum="2A5A418EF9AED888" modified="2019-07-31" version="1">MSNGHAPNNHPPHQPPPPPPPAHRAQAPTAKERITVKAVPSVTVQNNQLVVGDSGSSSTRSYTPLKLVGDGSFGTVWLCDWHGTLPPNTPLSAMQCGPGARPEYAGKRLVAVKRMKKQWEGGWDECKKLKELESLRAISYHPNIIPLYDFFLLPDTKELYFVFESMEGNLYQLIKTRKGKPLAGGLVSSIFRQVVEGLHHIHESGYFHRDMKPENLLVTTTGLYDYRPVSPHAPPNAPPESDVVVIVKLADFGLARETKSKPPYTEYVSTRWYRAPEVLLKSRDYSNPVDMWALGTIMAELVNLRPLFPGQGEVDQVARICELLGDPCRDYGHDARGKPIGGGKWPRGVKMARQFGLSFPEIPPRDIYTLFDRSVPIKLVECIADLLKYDPDLRLTSKQCLEHPYLLETTPLNNPPGPPGYSQPVVSNGRAARSSQPNGVSPARSPPSVAPRNIPPSHSHNSFPEQPEFEPQPPAATVQIPEASASHRTPFYDTPSSRTQVSDGGSTSPYPSDVAQVQLPNGSYPLRSRTPSEQSHGWPSYASDSQGPWDPMEISPHVEIPPDGFPQSMDVQTSPMLREYPARPQVEDSIQEIVSGNIHDITAHQASKGRGTGLFKKPSKWGISSMFGGHGDKGAQAPLPPLPEHHVSSAGSTPSLKRTQSSSTDSRSLSELSPIQEAPPRIVDPKQRKKEAERIRRESEKQRRLLAEKMQKEQARAVLEKSKRFRDPSASLDFEWRSSFAMIHGASNNGQRPNGKQPAAGGPIRQTQSHGVSSIDAAGGSFVSSVAESHPRSEWPGRDERLPKARRRDFDDDHSMSSTDMPSGVSVISFATVDSDPGPPRLRHRPSALGISRMTSMSSLGTLSDEFSPHGRSSSSLAMEQQFANEFHLRASVDSSSISDGGSSPAAPPMHMLSLSSPIPWSREHGSNSTVDNAEGRPAAAGERPTLTIPPQPTHPVGFQPQGPLSPYDPRGNGSYPSSPGIAPKSAINPIFKVPPLSSLQARPGSLPPFSQLEAVAEGEYPPLSPMSFTSPEDIGNDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDW7</accession>
    <name>A0A4Q9NDW7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_940738</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145261">
        <property type="protein sequence ID" value="TBU52208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDW7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="615"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="646"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="110"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="524"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU52208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="698" mass="76790" checksum="53198F0C6AB278CF" modified="2019-07-31" version="1">MSQHADRDVEAARGSSQQGPPDRTVDDPNDVSQENIFEDIEEIAEKGMKFVLMPVWARMKPEDMPTYPTWEESLHDMFVKCWYNIPFVVVPLALAWASHFDSEKWGNNTTFVLCFIAMIPLQKIFDWGGDEIGLFLGNEPRDLLVITLSNAIEAALAIILLFRCQLRLLQSTVIGVVLLHLLLIPGVAFFIQGAQIYEQRLHQFSNLNHSLLMIGVLGILVPTVFFAALDRGSVAAGSGDQSGLPAPFVPLVSDAVRRDIVQMSRGIAVMLLLIYITGCLYRHNVLPLPGHPEPVPPPARANTLNNALQTGINDGHHQSMPSTGIVNSISSPPRTVRSISSGTLSHLRTPTNSSFPPAQLNNCGKAPPPKSEVNPWVCVVLVIVAVAFMGVTAEFLVSSIETLLETSDIQTEWFGLVLLPIVSFSADGAVVVWNFSIALCRYAVRRIRSRRARKASSAETSTDTQAPREQKTVPTQRVLQDAPHIDYVDEPAEIESHHEPPTYGPRPSQSTSTLRTAKSREVASSDPNPNPSAAKANPRVRRRPTTGSNRQAGGNAGNEPKEQVEQDSSEDVLELPWVSEFAHGRPIDLSIQFTLWWTPFLVLLGWWTGRPMHLLFDYFEVGMLLGACFLVNYVTVDEKTNMSEGLTMISFYAMIATAAWFYPGQPQVAFMLNCPGTVAEAVAQGAEGTGQNLVKILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEN1</accession>
    <name>A0A4Q9NEN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphoenolpyruvate/pyruvate domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_934463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEN1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NEN1"/>
    <dbReference type="OMA" id="QIGLWCG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="286" mass="29632" checksum="787FFBD5BAAE710E" modified="2019-07-31" version="1">MATPVAHLAHPLLHALRASKPAFGAWITLPGALNARAAASASPHLSWVVIDCEHGLTGLHPGAGDSVHAIAGLGPDAPSTIVRIPATGACADGSASWQIKYVLDQGARGVLVPMVSSRAQAASIVAAARFPPQGARGFGNPFTQLAWGAGVSAVDYLQRANDSVVVLVQIETRDGYRNLDEILSVDGLDGVFIGPYDLSLSHGLPPPSPDPHPEAEKMIQHILAAAHAKGKKCAIYCTSGAQSARRAKEGFDMINVTSDSGAMADGLSRHLAEAVGEASAEQKFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGJ9</accession>
    <name>A0A4Q9NGJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ADP/ATP carrier receptor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_1005323</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGJ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NGJ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU60258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="647" mass="71698" checksum="F8261BAE753370BE" modified="2019-07-31" version="1">MSSTSSQGVVERVQNFVSEHKHAVLIATAAAVVAVGGVAYYASTSRGPGGDVEKGEGKKDKKKSKKRKTVKDEDGPLLEERKPKSAAVEEGSPGSHLRKNTSCLVKFKGALSGLSSLTPSARATTLAPSPPRWLVSTKCLYPILDDKEYTAEEIAALSQEERTKIAASLKAKGNSAYQQRKFQTAIDYYTRAIAVTPQPEPVFFSNRAACYVNLNPPQHEKVVEDCDAALALDRKYIKALNRRATALESLERFEEALRDFTAAAILNQFQDMNAAEAVERVLKKLATGKAQSILSTREKRLPSHMFTSAYFGAFRPRPLPALPENPTTGDNTLILGLEALGASDYAHAYTLVNEAIEQGISWDGGKAEALNLRGTFKFLMTDVESAKADFQASLELEPSLTQTWVKIASVWMEQGDPKKAFECFEEAIKHNPNDPDIYYHRGQVLFIMNEFGEAAENYTKSTELDDKFVFSHIQLAVAQYKSGNLANSMATFRRTLKAFPDRSEPQNYYGELLLDQQRYPDAIEKFDRAIEIERAKPPPMNVLPMVNKGLALFQWKQDIEAAEKCCQEALEIDPECEAAVATLAQLSLQQGKIDVAIKMFDKQSQLARSEPELISALTYQYATDAQVQFMHAYPDMAAQLGQMARMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NH07</accession>
    <name>A0A4Q9NH07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_50764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NH07"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043635613" evidence="3">
        <location>
            <begin position="28"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="536" mass="56563" checksum="88FBBD3D9A01F2CC" modified="2019-07-31" version="1">MTGCLPPHCPGCSRFLILLFTAAGALAGTTTRTIDDQDGDSVTGLIPSYSGAWNLGPQCTGCRVQPDQSQAFSGTWHDATAHAGEEIRTMTAQFNGTAVYVYGILAPPIQYITTLTNVTFLLDGALVGSYSNDPTSTDYQYNVLMYSNENLPNEEHTIVLQDTGDTNPSLILFDHIVYTFTDQDPSSPARLPPITSPTQQPTSPRATSSSPSTPSSSSSTQSLSSSLSYIPSSNPPTSSHDSSTSLPSSGSQSPTSSGDNVTSTFTSSPNAGEQRTTTNASPTASPHRSGAAVGSIAGGVAGGVAVLIIVAALLCCMRRRRRRAVVGPSQEKRVVDDPLPTTIHPFGASMHSTSTMQSPLLNGQHATNVSSTSALSVSEPSSVVSRWQMSRQENDKGVDSGVGEAPDSRPLPDAPVSPSIASPSLQLEHSQSNLTFSIPVMHLDSSSRTPTEQDSDHKSDIEFSAPSRLAAAPPRASQELPAPQTLPSPPIRSPTSISGVSTLRNQVVLLQEEITRLREEQELQRLLAEPPPEYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIA7</accession>
    <name>A0A4Q9NIA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_861046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIA7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIA7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="486"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="624"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="223"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="338"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="347"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU52926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="964" mass="107850" checksum="2C34F952383AFBC6" modified="2019-07-31" version="1">MPSLHSRMFLYARLGSLKSYIWKHLNFYRVHLLFFTFTPLVFSSILYAANTDFHVSYVDCLFNCVSAMTVCGLATVDLSGLTGLQQALLFIQMCLGSPVLVSLVIVYIRRTFFAKKFQYLVEAELARRAAQQTGMAVDVKLTPWWKKVHKFFGLPWRTRLRSFSDVVVQEPVKRGGGRYSLRPEMIRRVEGAPKLVDPSGWISAGVSQQPSENAIPRGNTAAAFPAESNHGITKERLSTSSGENTDSTGVERGDDHSQIPEQETPERRSSDMSPAQSPGTSPISAPPILRTETVHRQGRGPLLPRTQTVEFAATPQAFVLDRGFSPVASSVEDDVAYGTSHARRSMSRPTMSRRTTSRPTTLRPAMPRSMGTMPRSGTIMTAASHPYSEPPRRTMHRGFGGFPMPHELLGRLFGRAFPQLERRLTRTITIPRTRTIASERGAIPPGSRPVPYISFEAVVGRNSVFQALTQEQLEELGGVEYRALTALLWIVSLYHFGLQLLAFVVIAPYMSIHRWQSDLNPPALHKHVGSAWFSAFQVVSAYTNTGVSLVDQSMIPFQRAYPMVLILPFLILAGNTAFPVFLRFEIWILRKLVPRRSRLSETLHFLLDHPRRCFVYLFPSHQTWFLFTVLLGLTFTDWFFFLVLDIGNPVIEIIPFGIRFLLGFLQATAVRAAGFATVTLSALAPAVKVLYVLMMYVSVYPVAMSVRSTNVYEEKSLGIFNDDDDDSEAGFNPTGNRATVWGRYLAMHARKQLSFDMWWLGLALFLVCIIEKDGLEDEANSSWFNIFNILFELVSAYGTVGLSLGLPNANYSFSGALRPLSKLIICAVMLRGRHRGLPVAIDRAVMLPIEFGDHSDNGFGDEANSTRDYLPRRFSTMDATSEHSLEDLGVGNDRTRTLDRTYTQTQPRSGAPLNAEAPFGRGRDAAPKRVSIHADTMRDLESRVNNVVDQQIHKSGLATRHDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIG5</accession>
    <name>A0A4Q9NIG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mak10 subunit, NatC N-terminal acetyltransferase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_881489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIG5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIG5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031417">
        <property type="term" value="C:NatC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057983">
        <property type="entry name" value="NAA35-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007244">
        <property type="entry name" value="Naa35_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057982">
        <property type="entry name" value="TPR_NAA35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373">
        <property type="entry name" value="GLUCOSE REPRESSIBLE PROTEIN MAK10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21373:SF0">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 35, NATC AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04112">
        <property type="entry name" value="Mak10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25789">
        <property type="entry name" value="TPR_NAA35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAA35-like N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="NAA35-like TPR repeats" evidence="5">
        <location>
            <begin position="334"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU57018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="683" mass="78870" checksum="5094DEA924189419" modified="2019-07-31" version="1">MPMHSGFEDYLDIPGGDDFAEVTDLFVAGAQDMEPEEVLLMDGFTLMDAMSAFEIGEPRLDSGMILEEQRRPPFDPLTPLLPEEVCWILDRSFACEMEWHAGKTLSQSVFTILFVHHLPDINPEYLPPEEDEDPARPRWLITVVIRAAMLGLLKCCDFAWRELSKNRVHDIEDWQGEKCDVSLLEGVNSDLIMHLLDTASDWVQQSDLSDAQIDALCDRLYLRKTLLALYKLDLLKGVDQLWYHTTVGRELIDRMRTPDNPIPPDSSVHLAMDAYIARRLPNFMPIRITEIPPLGQIWDSLDAFLEFWAEIGHLVASPSLSLWKTAGQLRYSLHKRPACAFHRSLLQTLFFDKELVFGTYRPTRLVEQFFYETIGIPYPAITQAFKRSGPANPPASMQDVVERRIIRLMVPHIRSYWYNPPRRRRHLMKEVLQWHMLYDVMLKDVETHEPPDAETAAILRAVPLTARIWRLEQCREVILAGFQQELYAPEERPIAYWYLARVLDQHIACIEDVLPSVARDSGAYSELSFQADHLAALQMISTALIALTSMYITSTWKRISINFKRRYKWVLDPEFKTLTPAHPLPDLLSFPSMLDELLQDTLYSPSRTFELAENIAHRLSESPQEAVSHWDRDRRQYLRNLADACDRLKRGTPDSLIELPNLNVKTLKWIPDVHPWFPTVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNA8</accession>
    <name>A0A4Q9NNA8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1030509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNA8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13956" checksum="C4570CA12354533E" modified="2019-07-31" version="1">MSRHVASQDKRSFSSILLRDGATLLILSILHVVFTVNSIDTNEVGVASVLPLFEEPLTSILTWRFLINLQKAKNRLASSSCSMAQMSDPCFVLQPPVADNFDGFIGSLGARLIIHEDIEDEDMSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQP9</accession>
    <name>A0A4Q9NQP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_970545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145230">
        <property type="protein sequence ID" value="TBU52951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQP9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="347" mass="39357" checksum="795AFDD0C79EB878" modified="2019-07-31" version="1">MPVTFNVAQHDTDSATIPEGYAIPTEKDILKSICHREQWKEVGEILQSSVPKDTLESSVMTPAKNGFVSTVIEAYGKHDHLKIRVNRHSEELRNYFVALEGKKELMVERRGRDVNRYTIDFASIARDMSGEIDKHLMSTLKSYFSYKARLLCGIPSVTLEGEKADWERLYKRLDRLPELGEEPERWASMLRPILRRFVDAFDGRPDATFWEHVVHRESRICGSGSHKEHLLSGWITAFCVWDTKGTCLAGREMTSAAPSRAFRGNSDSDYVLDGVEYFTLDMDDVAEGYCEVDVLLDDNGEEIKCEMLSGHVAMTISEGQEGSGSYDTLSPAPQWFLYVKQPLKLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSP0</accession>
    <name>A0A4Q9NSP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_822439</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MT-A70-like family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSP0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NSP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036396">
        <property type="term" value="C:RNA N6-methyladenosine methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045123">
        <property type="entry name" value="METTL14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007757">
        <property type="entry name" value="MT-A70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13107:SF0">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05063">
        <property type="entry name" value="MT-A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51143">
        <property type="entry name" value="MT_A70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51592">
        <property type="entry name" value="SAM_MTA70L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="640" mass="67478" checksum="E4242C7A659355F4" modified="2019-07-31" version="1">MSVTTTECLASANELLATHNALVSRLRNTQRNFRRQLKTLPSPPNVILKLPLIPTPPRSPSPSPPSSPLLVPVPKPHRPDLPPAKRARLARYSNYVPEEETIRNDYSQRYVDGGEWPQNWVLGADPEHRFEEYPKQQRLLALKKAAVAAHAIPPTFLPYSELSSLQGSKFDVILIDPPFSSSFTWDDLQDLPIPALSADPSFVLLWVGSGSGEGLERGREVMAKWGFRRCEDIVWVKTNKTSNKGPGVRWLVLAWFPYHDNRRTSDGPTHYIPPHADEAALSYGHTRHHTDVLIWEGDSSDPTLKPPEMYTLIENFCLGLRRLEIFGRARTARRGWVTALAEGEEVRIEEGMTLGDEEGQEGAMRWNRETWEARIKDLAGGGQKLVVPVTADIDALRPKSPVRGGSTNAGASMMNSAMSAGSPMQMTLSMAGSGGAAGGGGGRGGGGGFGNQGRGAMGPPAMLPTNSMNTMGGGMGGMGIMGGWGGDMGMPGLGINVGMGGMGMGGMSSMGGPMGGMNAMGMAGMGQQGMGFGGGGGGHGGGRFGGGGFDGNMGMGMGGMGWMGNGEGQFMDGAGGGMWDAGMGEGMMGMSGMNNLGVMNNMGGMRMGMNSGMGQNMMGVGMGQGMGQWSGEGFQGGYTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTN4</accession>
    <name>A0A4Q9NTN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_915059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTN4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NTN4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744:SF17">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22744">
        <property type="entry name" value="HELIX LOOP HELIX PROTEIN 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="248" mass="28042" checksum="BCC8D825712648F4" modified="2019-07-31" version="1">MTSRISAPREFATSMVQVGRPLRNLPKRSAGNTPADMPAAGKCRHSDYCFDDGNVVLECQGTLYKVHRSILERHSPVFREMFMLPQPEGSIEGLSEENPITLEGLEADDFTRLLSLLYPPVLGDCKITTVEEWMSIFEQADRWQIDCLRDKALGNLRMSYISPIPKILFWMRFRLPEEDIVQPFIDLIARPNSLSLSEAQAVGLELLVKIACARDMARDEGLCPHSGGFSVRRDEALSRIVHEVFYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV38</accession>
    <name>A0A4Q9NV38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_932134</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV38"/>
    <dbReference type="STRING" id="114155.A0A4Q9NV38"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1176"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="246"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="419"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="749"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1177"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU56098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1203" mass="134905" checksum="04813FEF041364C9" modified="2019-07-31" version="1">MHILELILDGFKSYPVRTPITGWDPSFNAITGLNGSGKSNILDAICFVLGLTNMSSMRAQNQQDLIYKRGQAGVTKASVTIVFDNSDRSTSPVGFEDHAQITVTRQIAIPNLSKYLVNGHKSTQQNIQTLFQSVQLNINNPNFLIMQGRITKVLNMRPAEILGMVEEAAGTRMFEEKKEKALRTITKKDKKVQELTALLEEEIKPKLDKLREEKRAYLAWQKTCTELERIGRTLRAFEWTDATQRAAAKDKEIEQAKSAKEVLENEKMQFSKEIKAAEKSMAEVNAQRDQELKKGGKFKQLEEKVSELGKTVAKVKTQVEIKERTIADEEGKIASSEKELEELRASVENKRKQVEQLNAAHAEVKDKQAALQASLNSSEELLQTLLTGLSSSNAGNTGGGYMGMIGEAQARLAVAQTDEKSASSNLERSKSELKDLEAQWKKVEREASDAKRSLDAMRANVEGFKRKLAETGWSAEKEYEHENNLRDAKNEVRRLSEVRDAVKSRMRNLDFEYTSPHQNFDRAKVKGLVASLVALDKVNYNASTALEITAGGRLYNVVVESDEVGKQLLQNGRLKRRVTLIPLNRIESFRVSPAKIQAAERISGGKARLALSLIGYADEVANAMFYVFGGTFICDDAQTAKQITFSREVGVKSVTLDGDIYDPSGTLSGGSAPSGSGVLVQVQELIEAEASLQQARDELAKLEHEEQRSRDVRDKWRHFARDLGLKEHELELLQKQVEASNASRIGGEVEHKKQAIADLQAAIQTAQAKQKEAKAEIKKLEKDMADFKNNKEGKIDELKKEVGKHKSDLQKHTAQMKIQQKEVQTAGLELEQLESDITLSEAQIQEARDAVQRVRKELDKLKADLKHHEAAAASAEQKLAEERATLSRYDEELKSLERVIKEKKAAIADADLEIEKRALEVESLTKEKASLVKAAAALEKQYDWIAEEREQFGKPGTPYDFRKADIGQLRARANELQSQQNGMKRKVNAKSIHMIDSTEKNETEIKKKLAQVLTDRNNMMETIETLDQHKRDTVEKVWTKVNGDFGAIFAELLPGNFAKLQPPEGQDLMQGLEVKVRLGQVWKQSLTELSGGQRSLIALSLIMSLLQFKPAPMYILDEIDAALDLSHTQHIGQLFRTRFKGSQFIVVSLKEGLFTNANVLFRTRFRDGTSIVERTANRSTSTLYTQNREQEEENLPPAGRRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXK2</accession>
    <name>A0A4Q9NXK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_931175</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXK2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12858" checksum="9458396BB02C7C17" modified="2019-07-31" version="1">MLLCRATLSRALRSCPGQFRVQSATRLAGSIATSSPAKEFRVVLDNGTLYIDQELAQSLGWHTEVNAAEGVPLTLHGWGPHYFAISRTGSDSEALARRTAASGNDLKVLKVLEYLKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZX6</accession>
    <name>A0A4Q9NZX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Arylalcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_811363</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZX6"/>
    <dbReference type="OMA" id="YWIDILY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="29"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="375" mass="41435" checksum="9BBD34F1FA4FD11D" modified="2019-07-31" version="1">MAQFQAAVPKTKLGRYRQLAPLAGLHVSPIVLGAMSIGNTSGATVGSAVDKDTSFKFLDAYFDAGGNFIDTANYYLEGSSEEVIGEWMEFRGIRDQVVLATKYTLPFKFKEENITQRVNFIGNNMKSLHVSVESSLKKLRTNYIDILYVHLWDWTCGVEEIVNGLHHLVAAGKVLYLGISDTPAWIVSKANMYARQTGKTPFAVYQGAWSVVYRDIERDIVPMVKAEGMALCPFGVLGAGKIRTDAEEESRRETGVKGWERSEAEKTIAKVLEGVAAEVGANTIQAVAIAYVMQKMPYVFPIIGGRKVEQLHANIQALDIVLTPEHIKRLEDALPFDPGFPIKFIGDGSAYAPFYSMAAQFDKWPAPQPIRLSTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P016</accession>
    <name>A0A4Q9P016_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_1004022</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P016"/>
    <dbReference type="STRING" id="114155.A0A4Q9P016"/>
    <dbReference type="OMA" id="VIRTMNY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="16">
        <location>
            <begin position="227"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="554"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="573"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="575"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU60590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="593" mass="63415" checksum="67D10E0FC6FDA13D" modified="2019-07-31" version="1">MFWSSALILGLAHLAASKPLVSKRWDDFGVKHAWVDVPRGWELHGPAPADYTFDMRIGLKQDRFDDLVAALYEVSDPAHERYGQHLSKEEVAALIAPHPDSVDLVESWLHAYGLSAANSERSPSGDWITIRVSVAQAEKMLGTKYNVFRHSKSEDYVIRTMNYSLPNVLHEHVAVVAPTTYFGTMKSMKATSFVKENAPTIESDVDVAHLLTGPSSLATVPSSCSSTITPACLRALYNTSSYVPAATDKNILGVAGYLDEFANRADLQTFFKRFRTDAVNSSFTTVQVNGGGDDQSDPGVEANLDIQYTEGISFPTPNIYYSTGGSPPFNSDENTPTNTNEPYLDWLNFILAQDTIPQTFTTSYGDDEQTVPLDYATSVCNLFAQLGARGSSILFSSGDDGVGGGDCLSNDGTNTTKFLPNFPASCPFVTTVGGTIRINPEVAVSFSGGGFSNYFARPDYQSTAVSTFLTKLGSTNKGLFNTTGRAYPDVAAQGENFQVVIGGRVESVAGTSASSPTFAAVISLLNDFRLSQGKSPLGFLNPLIYSTGVPGFNDITSGTNPGCGTNGFTAGAGWDPVTGLGTPDFGKLQALIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P027</accession>
    <name>A0A4Q9P027_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_620713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P027"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8348" checksum="B46B9F82C942FA33" modified="2019-07-31" version="1">MILRMAYRSCCSASLHHCVPLTLLLSYFSVPSSMVYVSRIHGSSTFDVFDLFQFLRPNYSATLNAVVVRSSYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1Z5</accession>
    <name>A0A4Q9P1Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_905320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1Z5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF44">
        <property type="entry name" value="PROTEIN AIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="27"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27106" checksum="399E7C15517FCB49" modified="2019-07-31" version="1">MSYCADCFKGVRHEGTPEGTTQTIGGIECYVAIPAGDYPKDKVVLYLTDAFGLALENNLLLVDDFARNGFKVIAPDVLEGDPAPVDAFSPGSNFDTAAWIARHPAAKATSIVRSVIDALKAEGVTKFGSLGYCFGGRLCFNLAFTGDVDVVAVFHPSQLKTPDDLKKYFEVAKAPLLINSCEVDQQFPIESQKVADEIFGEGKFAPGYQRTYWPGCVHGFAVRGDLSKSEVKAGKEGAFKASVEWLRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P331</accession>
    <name>A0A4Q9P331_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Brg1-associated factor b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_451001</name>
        <name evidence="3" type="ORF">BD311DRAFT_751273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P331"/>
    <dbReference type="STRING" id="114155.A0A4Q9P331"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU32092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="440" mass="47612" checksum="7759C34912406183" modified="2019-07-31" version="1">MVNYGGDEVSALVLDFGTSSLRAGYAGDDTPKAIIPTSFGFIEEPAEANGGDVTMGEAGATEGEQPQASKPKVKLYIGQNGPSLWRSGMQIGNPMQDSLIQNFDAIPPLISHALSEVMRCNASEHPVLVTEAAWNSPANRERMAEIMFEEFQVPAFYIANTGVLNAFAAGKGSALVIDVGHSTASVIPVVDGFVLRKGLMHCALPQLVHAHAKHLLTSPTPTRQGIQLIPHQLIASRTPVDAGVPPRFTLREDRRAGTTDSWRAWAENREVEEWIQSIGGVLPQGWNDSAATSQGSRHYEFPTGYNNYFTGVERYAVGEQYFAHSAQLMASNPNLPKTIPSLVTSSIGQCDLDLRQVLLGNVVLTGGGSLFAGFADRLANDMGRAFQHVKIHAPGNPTERRYGGWLGGSILASLGTFHQLWISKEEWQEHGRAIVGQRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3V0</accession>
    <name>A0A4Q9P3V0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6697 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_820694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3V0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3V0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046520">
        <property type="entry name" value="DUF6697"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20411">
        <property type="entry name" value="DUF6697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6697" evidence="1">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="173" mass="20237" checksum="234A65CB90F8086C" modified="2019-07-31" version="1">MLLSDEFLLDALTWEGLNHRYPVPLPEGVAEFGLSRKYICSLYGGCRRGTFIKPGDEWLGWHGLDDWVYLTMEFAPHAPTKPGRSGLFFACNRATETWPPEINKPRRLFVRLAHSQWVYMGQYRMAPGLSLTADAWKQQKDQVRRTWTRSILHKQWGFQNLARIWIRKEKGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4K1</accession>
    <name>A0A4Q9P4K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1035228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4K1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P4K1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="220" mass="24603" checksum="F8A871F4E23795EA" modified="2019-07-31" version="1">MKIVSKEQQDAQQRATVIGGLKGMAGGFAVSIPASLYLQRTNAYYRRLQPSLKAFGVIMVVVPAFVISAEHAGQKYEQEQWHDAGKAELDAQQRRQEARWESLTPGQKISDFVRRHEYGVIVGSWAVAMAGALRYVMKDPLQSTTQKVVQARVWAQALTIGIIIAAGILTHSQRSKELESMDEHNVRHLPPDHSWLDVLQEQEKEKEREDAGSTNTRGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6D8</accession>
    <name>A0A4Q9P6D8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_1038911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9P6D8"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1068"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1074"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU58875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1823" mass="206351" checksum="D9F45BA8921DFCB7" modified="2019-07-31" version="1">MSSLTSFFPSRLLGSMHSNPRDRQTDPLSRLRFTLETMPGSRKYNFTAATRAEILAELYDAFWGSYAHLFLPNSNSSLPLHATLSEVQASVGQPKETQVVPGRQCGHIFKKGESCFRCKDCALDDSCVLCSRCFNATDHTDHNVSFFIAQQPGGCCDCGDVEAWRQPIDCPYHPPAPETVEYIASFESRTLLNTPRAHPKTLTGQDIPPVKNYPHRAFVPPELKESICRTMGYAIDFVLDTLDSSPDETIVPVSETDLRLQPTGDPLMHDLFAVVIWNDDKHSFDEVIELLHDITNRSREEAAQVADRIDEHGRDIIEMSTNSARLLEIAQAVAQIDIGVTVRRAFDTFREQVSAVIIEWLLDLTRSRLSSDTLILRELLAMELLSPRRNSSLLSAQDPNRVLPDIHEPTRLDWLFLYHARLWKKPRLNLKEIYASLLTVSHEHKLATASHFASVYHRIIDAYLLSDREAETSIKYFALQLFTVASVALYIVRHHNIVSRLLAIISAFFTNQIQDKRIIFPPNPEAEIDVDTFPFKSKRFMPVFSDLRYLCHNEPVQQLIAHNHEFISQFAKTCQIFMCINPNKRAASSHVEYETDAWISVFNVTLSLSRVIKVYGEAYSKATVGELVAAINTVMHHILMCITVVDERRDLARFPPVEFHEVVYGETTYKIIDFDVMDGSISFHHSLQWLLAELFKHVDILDESSLKTVGLRSLRDVCLNKASEEAMLTIIDYPLRVLAMIAQIRTGLWVRNGFAIRGQLLHYRDFMLRELCYDQDLFILQTALVVLDPNAVIVSMLDRFQLLGYFSGATLHPSYDASHLSGMVEEFLYVLVTVLTESASATKMPLPIAVRREIVHALAVGPCTFTDLVKRVAERMVDDVCFERVLKEVANFKPPESTADLGTYELKDEAFDEVNPFFYHYTRNKREEVEVVLRNRLRKKLGVHDPVVVPKPLNITKGPFVVLPSIFESEVLVQIFFYGIYNVVTLTDATGAAPPSAEAILDQILHLTMVACVERPQIFSGLAVYKTYEEGKTLLEVLCTFEYHEKYPTYKARVQWLVDQIARHQPSLVQAHRRVPDESKADAEDPKEAKKRAAKARQEAIMRQMKAQQASFAVNFEDIDDEEDDELIDTPETPVSYGTCIVCQEELNNSKSFGSLGFIQPSRQLRRHPDGLQSYTNEALNCPESLDRAATTTSDMSFPPSSSDIKAVKHIHGTNFDAFPSSSTRFGLHASICSHMMHLDCFTVYSGSIRQRHRNQATRNHPESIPRKEYICPLCKSLGNVILPVVAPKTPEVNTVPFPDWIRAASISILKSKPDPVLESLQFRTGTGEFVFWTAQDSAYQSHLRVIDRPDNTELHKMVDTVMVVAKNVSQQSRHLRERAEPEPGERGAGMYLPEELVGYTVSALEVALRGQGTVGKTVADSVTDSQYRMVRGLLTCLTKLVALNFKGRPDEGREAVRQAIIKRLLPEWSRTSFTSFSHPLLLRDPFTILIETAAVAPEMLKHALVLTYYAYLARAVVGLVYVLNKSRSGQTTVVDTRKYEDIFGDTRMFFMSVVRHSPIFEQAADGVFLSFGEARIEQLLYSFTLPFLRRALILCRAALPNAFVAPSDLDPSACEYRRLLSIMEIPSLADLPKHDTLQNALSGWCAHYGHSQAASQLNCGVMLEYPLIYRLARLPLVLDHLYLDQDKTMVCSRCRTVPLDAAICLFCGTTCCFQSHCCMDLDNQYRGECNMHTRECSGPIGLYFLVKRCSLLYLYANNGAFGQSPYLDVHGEVDVSMRRGRRQYLHHARWEDVHKIWLNHGVPTLIARRLEGTVDNGGWETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6F0</accession>
    <name>A0A4Q9P6F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_120457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6F0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6F0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21307" checksum="A3A13A96FC1BA3DA" modified="2019-07-31" version="1">MWCDNCLLLLPLRGGAIAWGVVMFLYSLAGGIFLLIRGQYLFFVFPEWQIYGGIGIAVGVAAALSILALSNRSYIWIRVCKFVWPFVIVIAAVRAIIMIVELQRGKDKIQWECDNGGQLWSASAAAGYGTSSETFPSGFCAAGFSSLNVAFIVGLLVDLVFQMYMFFMVWRFQKRLEHYSGMKGPFYGGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8P4</accession>
    <name>A0A4Q9P8P4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8P4"/>
    <dbReference type="STRING" id="114155.A0A4Q9P8P4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903259">
        <property type="term" value="P:exon-exon junction complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039333">
        <property type="entry name" value="PYM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015362">
        <property type="entry name" value="WIBG_mago-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036348">
        <property type="entry name" value="WIBG_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959:SF0">
        <property type="entry name" value="PARTNER OF Y14 AND MAGO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22959">
        <property type="entry name" value="PYM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09282">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01273">
        <property type="entry name" value="Mago-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101931">
        <property type="entry name" value="Pym (Within the bgcn gene intron protein, WIBG), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="19983" checksum="4C2070670F8F5448" modified="2019-07-31" version="1">MSKPAIVPETTTAGIAVDPRTLERVIPESRRPDGSIRKEKKIRPGYTPQEDVRRFRGTRQAQAEANALPKGHIVGWAPPPKAAAVPVSKASMTKAQKKNEKRKEKRKEKTVESEKVKDNWEEDDDEGEAEGTSTATKEAPSVDREGVHTANKPNWAVAPDTKKGDDAAAEGLADKLDKLEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA79</accession>
    <name>A0A4Q9PA79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_119781</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA79"/>
    <dbReference type="STRING" id="114155.A0A4Q9PA79"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000451">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="12">
        <location>
            <begin position="676"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="13">
        <location>
            <begin position="816"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU62096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="953" mass="105945" checksum="9568716C9808B88D" modified="2019-07-31" version="1">MASADASCYTLVFEDASETPTTADLRAGLQKGSDEVKLDTLRKIIVSTINGNPQPSLLMPIIQYVMPSRNKQLKKLLHFYWEVCPKYDDNGKLKQEMILVVNAIRNDLQHPNEYIRGATLRFLQKISKDAELLEPLIPTCRSCLEHRHSYVRKNAVFAVYSIYREFENLIPDAPELIQTFLAAESDATCKRNAFVFLAQCAMPKAVEYIVSVFDQIPAMDELLQMSIIEVVRLDCKQETSHKARYILLISELLNAPSHAVKYEAATTLTSLTQNPAAVKAAASCYISLVQRESDNNAKLIVLDRLDALRSKHGHVLDPLIMDILQILSSATDLEVRRKAIGIVLSLTSSRNVEEVVLFLKKQLQKTQDQEYEKAPEYRQLLIQSIHVCAVKFSEVAASVVHALMDFLGDSSNPSALDVVAFVREVVEKFPQLRGTICEKLTQTLPEIKSGKVYRGILWILGEYAEQTAEIEEVLRELRKVLGEIPILASEQRLLEEAAGAEDGEERKDEVRAEASKPKVLADGTYATESAFTSVSSARLEAVKAAAKPPLRALILGGDFYTGSVLASALTKLVLRFSELSSDKRKVNALRAEAMLIMASVIRVGQSKFVTVPIDEDSTERIMSCIQTLSELESKPPVHEIFLKDTKAAYSKMVAAQEKKAAEKKESEKAKAAIVQVDDLLTFRQFSKRAADDVIDDSEDVNRATGAGEVTEDFISNLSRISQLTGFSDPIYAEAYVKVHGFDILLDVLLVNQTADTLQNLCLDFATLGDLKLVERPSIYTIAPHSFQSIKATIKVSSTETGVIFGSILWEGPGMAEQCVILNDIHIDIMDYIKPAYCTEQQFRSMWTEFEWENRVNVTTTISDPREYLEHVMKATNMSCLTPEGALSGDCDFLSANMYARSLFGEDALANLSVERTEAGTITGHVRIRSKTQGIALSLGDRITMAQKDNKPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAX7</accession>
    <name>A0A4Q9PAX7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_982436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145299">
        <property type="protein sequence ID" value="TBU51628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAX7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="198" mass="22422" checksum="8F8CE8EC9758FAA1" modified="2019-07-31" version="1">MAILTPRLLSHKEEHAHSYAILEAAREAAKASHEYDSEATWQRLKDTFRQQWYDGSVGHSPTTPAHSVIPPNHTVDSIVLDEDEDEHGLGLHQQAVASRAGFPVRNIDNSLRPRKSPKQRKGTHLKTMKTALIDWQYTTQCIRYKFSSLKAENILPNGALTTIASLCRDLKTIQDLKRVLNPPWPHVDNHGEELLKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBF2</accession>
    <name>A0A4Q9PBF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBF2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="622" mass="69026" checksum="66248556DD8F476E" modified="2019-07-31" version="1">MFPSSPMITDHPRRSISDLADGDSLAPSSSQSLSSSSRKSQFSRDRFFRNKHGSKVHAYDPNQAPWPLSYDKSTLELEMMDTALTSAFKGVVSLVDHKGKEPARCLDIGTGLGLWIVNSAKYWKNSTFVGFDLVDIQIPVTVLPDDEAARIEWVHGNILTDPLPFSDGEFDHVRLTEVALGVPENKWPDVFEEVRRVMKQGGTIEIIEEDAIFPVLPRWFTEPLHARTRWPSISMQDRSKAFSNPQVSAQSQVAHEYELLEILFENVFQRRFINMKPSSSLPAYFSVYFGHVLSPPVLTVPMPPLPPVQPRPPPRSSTSSHSDSYYGDPDLLYDAEAQGEMSLATLHGPVRKKKGKSSVKRTSSSISPSGTSISSGGASPLARSYSEQQSRKSLNGSTGSLHGHGNGNNTTPPPPLPPIHTTVTASGMPISSGPKIGGRSRSYSGASMMSMASKRKAAIQDLAAASTVIGGRSQIELFPLDGLLMFDVHSLCLHLRRALGFVLAIREAMWEELASLVTSPARDVDLTKYGFFPHEDTLENIRSKYLQLLDQYKSDMHVRMSLWHSLVHFGWDYPQRDPMSKAEEMEEVRLREDILMARREAGAENEREPPCRAVRMLVGAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC96</accession>
    <name>A0A4Q9PC96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941846</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145296">
        <property type="protein sequence ID" value="TBU51655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC96"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="92" mass="10298" checksum="70ABF31B2461F7AC" modified="2019-07-31" version="1">MDIRQTSKNTGSVPPYHLTSFFMREMLFASDYTPRSDWKSPSLIIPATRIADTIVVTAITTLVTVLISWKQLQATAIKKDNNAQRMNAVGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDB4</accession>
    <name>A0A4Q9PDB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="11 12">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_202958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the peptidase C19 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="11 12"/>
    <dbReference type="EMBL" id="ML145236">
        <property type="protein sequence ID" value="TBU52799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDB4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDB4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000086">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000103">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF664">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11 12" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11 12" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 11 12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="653"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="711"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="723"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR016308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU52799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="804" mass="88127" checksum="8C5B78F66154F28B" modified="2019-07-31" version="1">MSCGHIGDIARLQPPKLSQSVHREECTQCFDNQDSPLGVDVCLTCFNGGCLDKERHHARSHVAKTGHSFTLNVKRKLKPSANRAEDEEPPAKMKKLAIVEEREEDKYEHKTVLKCWKCDAQNGLELPDASADPHVQFLVTGIMQSLSSARQSEVKAWEEEIAACEHTLMLEQLATGPIAASGLAHCQKCDLKENLWLCLTCGSLGCGRQQYGGFGGNGHGLQHYEETKHPVCVKLGTITPEGTADIYCYVCNDSKLDPDLARHLANFGINVQTQTKTEKSMTELQIEQNLKFDFSLTGEDGKALEPVFGPGLTGLSNLGNSCYMASVVQTLFSLAPFRERYLPTAATHWEVCQESLPANCIDCQMHKLADGLLSGRYSHPRPHAASSPSAPKETNPLAPVFQEGVRPSGFKALVGKGHEEFATMRQQDAEEFLTYLITVLRRHTKRLGLDPTKEPTGVFAFGMEQRLECGECRRVRYRVDATDAVSVPVPAREKGKDAEGKTVYEEVPLKECLDILTGTEALEYQCPSCQKKVIATKSTRLATFPQVLVVHAKKFQLVNWVPAKLDIPVILPENDVLQLDEYLGRGLQPGETELPNDEAVAAPGLPQFNEAAMAQLEGMGFPTIRCQKALLATGNADAEAAMEWLFAHMDDPDIDAPIQPQAAGGSGSPEPSAEQVGMLADMGFTEKQARKALRETGGSAERAVEWLFSHPDDTGEDAPSISAVPSGQQQSTEVGGSSKLPARYRLKAFISHKGPSVHSGHYVAHVHTATEGWVLFNDEKVVKADAESVRELKKLAYLYVFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDD1</accession>
    <name>A0A4Q9PDD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_952484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145235">
        <property type="protein sequence ID" value="TBU52819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDD1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="463" mass="51030" checksum="FBBB7CED8C427331" modified="2019-07-31" version="1">MYTDGLPPSIVSPISSGGPNTSNKRSRIESEEQSRRSPVEQERVAQHKQPVPPVQTPAAPTPIYRGNPPPVAPTNLQALQIPDSDFPHAHVPEFRIFGNVSVDQVQRIRDISNPKVAIVIHGGGQELVAAGGPLKEKIFQLLSAITFPPAASQSMVIDGSALDGSGSPPSNSPSSAIHIHLPIPRKSRQTSAFNQPWCWFVDLGPNSQRLCEWLLFQEVFPISPALSFSVHPFTATVQPWNIMVLTGLDECAVEDSDAARRQVLKDIKAYLWKDRDFTVRTARHVQKYWGLNGDPVSLLKAASDTLHVVNVVAELKTSRKEVPAYLVYAKPVSNDKSEHLEWAAKFTSPDAYWRGAFRLDINKAAVECKLCKDTSHCARACPLATDGWTGTVVEDIYTTQELEARAAGSSTSASSRADHDWQQVKERRLDRDTRAPTVGKHSQKKKQKGPRRDSQGKGKGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDJ9</accession>
    <name>A0A4Q9PDJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_982707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145340">
        <property type="protein sequence ID" value="TBU51317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDJ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="50555" checksum="2350C8520DAF95F7" modified="2019-07-31" version="1">MGEGRGHLNHNASRFPVEVCENIVDMLYSFSLIDRVEDSRALHRCALVCRAWHVRSQRNLFYSVVLHDLPALQKFSAVLDNAPHLCDYVHEVALIWRTLHTTTSPLSLLPIALYGKLPKLQEVIINRIREDEDWYPRSSELESAKSLQYLPLHPRFALYFSAFTTVSRLYIVNLTFLHFNDFARMINSLPELQELECNTVRCVTLGPLPFNMKPRADGSHAPATPFAPKLQKLRLYRVDIHCVQRLVSACGPRLRGLLVTMPFFYDAEMVVPGDPTTESPVDVDLSVCSTLERLDIFLGPELVTEGQSLDQLKAMLGSWEPEVPLLDVYLQPYHEHNFTRQDFADLLGPVGRILEHVFDDSSAPPSADGEVDEEDTEWRLVVSLHDGEVWLDWWRRHVIDCFPGFAMPHDLRVICRLPLYDQFKWKDRLDSDSDSDSDSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE25</accession>
    <name>A0A4Q9PE25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome b5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_921205</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE25"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="34859" checksum="758854789B56D079" modified="2019-07-31" version="1">MSWFLNPDGDRPQRRRPEKLKDFPKDADGKPLGPQTPGSAPTSPWTDFPLKDDYPTVDDPVDPDRKVSTKQANRPFLAYAQYRAEREQAHKEWLQRKQQREEKLARGEEVGPEEPDPTEEVEVGCLGLLKFILYATLFIILAGKFFTGSFLWEQELPNLRQFIPTNQRLFSETLLAQFDGSDPEKPVYIAIDGDVYDVSAGRATYGPGGSYHMMAGKDAARAYGTGCFKTHLTHDLRGLSESEMRGVQHWKKFYAESKKYHKVGRVSHPPIDPASPYPEHCDPKKAEAAREREREAQAEARKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEH9</accession>
    <name>A0A4Q9PEH9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_161158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEH9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="26495" checksum="B3FD5C014EF55092" modified="2019-07-31" version="1">MIINISNSIVRGCFGVRLYRLGHGNWWLPAIISAFSLFILLDAAYFAAKLWNAHSYAHIQDFSWALYTGLAAESAVDLIVAISQCVLLRKFETGIRSTDSVIRVLMTYSINTGLLTSFCAIGAVASFAAAPRKFIYFAFYFALSKLYVNSLLATLNARGSLLGKGSRGMRRQHYKQGAFRAPTLSAAGEAGRREGVSASALDPSGYGPGIEFTTVISAVPFETDSVVGTTKTKIGSSEHSESYCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFB5</accession>
    <name>A0A4Q9PFB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_861159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFB5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF11">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="38726" checksum="A59D04C7205882A9" modified="2019-07-31" version="1">MSGTCEIHHDATANALTVFMCIGITISYLPQHWRIISAKSSEGFSPWFLLLGSTSSASAMLNIFVMQWGLVRCCRELPFGSCIESIAGALQLVLVWILFVLILVLYMIYYPPHLKYVELDVDLPNDLPPQHIKTPVKREGWKLSITLTWAVCIHIALITFVTFLLLSTNPTPDETHRSRQLELWATFLGVSSALLAALQYAPQIAHTWSLKLVGALSIPMMFIQTPGAILMVLSIALRPGTNWTTWISYAVAGVMQGILLVMCIIFRARQHTLGIDDFGRPLTPPPSYPASQEAEAPAGTPAVEAAVGDAVHADVRSTHGVDLVGEVGEETPLLREGASGKRRMGWWAWLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFJ7</accession>
    <name>A0A4Q9PFJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_833228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145275">
        <property type="protein sequence ID" value="TBU51947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFJ7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFJ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28985" checksum="9B812D27B0844B4B" modified="2019-07-31" version="1">MSCSESDLNSCNVGDICDVLSNPLPDGSPPPARPARAANDYMPYESRVHFEIADFLFRKAKVSGGNTDELMQLWGAFSERAPFADHKELHESIDSISLADIPWQAFEVTYTGPRPEHDVPAWMEAVYTVWYRDPRNVLHAQLGNADFADEMDHSPKRMYHGAERVYKDFMSGDWAWQQADTIAQDPTTHGATFCPIVLGSDKTTVSVATGQNEYYPLYLSNGLVHNTVRRAQRNAVSLVAFLAIPKSVYLVFLPCMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFM1</accession>
    <name>A0A4Q9PFM1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1010836</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145396">
        <property type="protein sequence ID" value="TBU51106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFM1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFM1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020645665" description="Rhodanese domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="142" mass="15733" checksum="6EBB258A09E3E84F" modified="2019-07-31" version="1">MLDALVLSIVLVDAINSGTSMEGREAAVAAWEVCTEPSTYIFQRDRSTIEDALSISPRDGSVLSKNRDKFDLVTIYDDVFENMGDVHSPVSVLFKAIHETAFCKILKSVSMLLIGGFQAWKHEYGKEETLGPPHQVRVLSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGA7</accession>
    <name>A0A4Q9PGA7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 14">Homoserine dehydrogenase</fullName>
            <shortName evidence="14">HDH</shortName>
            <ecNumber evidence="5 14">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_982130</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of L-aspartate-beta-semialdehyde (L-Asa) to L-homoserine (L-Hse), the third step in the biosynthesis of amino acids that derive from aspartate (the aspartate family of amino acids), including methioinine and threonine, the latter of which is a precursor to isoleucine; production of homoserine leads to a branch-point in the pathway as it can either be O-phosphorylated for processing to threonine, or O-acylated for processing to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-homoserine + NADP(+) = L-aspartate 4-semialdehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:15763"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:25213"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="5 14"/>
    <dbReference type="EMBL" id="ML145269">
        <property type="protein sequence ID" value="TBU52051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGA7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGA7"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000006">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011147">
        <property type="entry name" value="Bifunc_Aspkin/hSer_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022697">
        <property type="entry name" value="HDH_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43070:SF5">
        <property type="entry name" value="HOMOSERINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036497">
        <property type="entry name" value="HDH_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="19" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 14" id="KW-0791">Threonine biosynthesis</keyword>
    <keyword evidence="19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aspartate/homoserine dehydrogenase NAD-binding" evidence="18">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Homoserine dehydrogenase catalytic" evidence="17">
        <location>
            <begin position="204"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="15">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>L-homoserine</name>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR036497-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU52051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="405" mass="43039" checksum="31AD18143A7FD5D4" modified="2019-07-31" version="1">MAHLLGITSTTKTFRVAIVGVGLVGAELVKQLQALQPSPFRIVSLSSSKSLLYHPDGLSPSEDWKTELASSGRRPDLHFLLRELAALVKPGQEAVLVDNTSANEVAALYPSFLRLGVHVVTPNKKAFSAGLELYEQILGASLESGARFLNEATVGAGLPVISTLKDLVATGDKVRSLSVSVFLSPADSGGWEGWLSVCADADAERGAQVTKIEGVFSGTMSYIFNEFSTGKEGGPNFSSVVSVAREKGYTEPHPADDLNGADVARKLTILSRLIPSLRSALPDGYQFVSTKSLIPPALEGIESGDEFIRRLPEFDAQFDQLRADAIKEGKVLRYAGVVDVQNGVIKADLEKYPATHPFATALGGSDNIIMFHTERYGARPLVVQGAGAGAAVTAMGVMSDLLKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGA8</accession>
    <name>A0A4Q9PGA8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_245172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145258">
        <property type="protein sequence ID" value="TBU52287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGA8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGA8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24796">
        <property type="entry name" value="WDR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="326"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="418" mass="45932" checksum="2F45ADD9984C0C6F" modified="2019-07-31" version="1">MPDIPVGAQIFDLAFLPEQPLVTTGLLTGYIKAFSYDEQGNYEEKFSIRPSKKSCRTLAVTEDGSKLWAAGKAKAIYTVDVGTGEVVDTRAAAHDVPINRMKRLLPRLFASGDDDGVIKLWDPRKQEAVRKYTHHSDFISDFMWLDDKKQLVATSGDGTLSVMDIRSKKLEPVAQSEDQEDELLSILPIKGGQKIVVGTQLGILSIFNRKNGWGDCVDRIPGHPQSIDALCAIPSRYSNAQSTILTGSSDGLLRAVQLFPTKLLGVVADHGEFPIERIAVDMGGEGRWVGSVGHEEVLKLTDLQEVFENDSDEDEEAESGSAGSDADLDMENGEGGSDEEGETKTGPSKSEVKDAVEDEHVDEEEGTKEKAADSSDEEDLDPEPRKRKRKKEQDPLHAMKRRKGKNEVEAEPTFFADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGB0</accession>
    <name>A0A4Q9PGB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WLM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1043113</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145257">
        <property type="protein sequence ID" value="TBU52297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="AlphaFoldDB" id="A0A4Q9PGB0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053000">
        <property type="entry name" value="WSS1-like_metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46622:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="7">
        <location>
            <begin position="1"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="419"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="501" mass="53104" checksum="6CBA1BACE40FC76C" modified="2019-07-31" version="1">MPDVFVQSFTHLNDKPNADQALDLLQRIASLVEPIMRKHAWVLPVLSEFFPEDPNLLGQDINGGEKILVRLRPPHAPDSFLPEDSVVGTMLHELTHNVHGPHDAAFYKFLAGLEDEYDALRRSGWSGEGFHAAGRRVGANVSHNLPPHLARARAAQAAEKRRQLSVVLGSAGRLGGGPRRPNKSPRELAAEAAERRARDELTCASTSGVVAQTDLAEKAAGASVRDEVIDLTGDSDSDSEPELLIIEEEAPSPQRSTSPASLAASASISASSSALSLKSAPPTTTGSTSRLAPPDRAPSSASLPALASSTTTSTSTSTPDSDRMTRPIVKRVPHGAGDPRPTLPKPRSVSRHPAKRPPTSWTPTPPPTRATSVVHPRSEQYHPHSHSHLHSDSDLNAGSAADPTADGDGDAFAGASIPLETEWACPRCTLVNDALALQCAACLGVRPPPPARPKSMAGDRKEKEEVEKDGGGGWTCGVCGEREMPSDFWSCRFCGSVKAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGH0</accession>
    <name>A0A4Q9PGH0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1042373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGH0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="28117" checksum="DFACBE4B511B5317" modified="2019-07-31" version="1">MMAYCSLCNRFFKSERALQQHRDDSNMHYICYKCNMDFASNATLILHFTNSPQHPYCPWCDDHFGDYGDLFAHFVDAHFYCELCNLAVLAVPLQQMFPFENALHEHRRFAHAEDYCVPCKRMFKNTNALRHHERSTFHKGRTIDCPMKGCIKSFVSRAALVHHLESGGCFSRITRDMVNRIVAKLDTHGVISDPTKLIGPGSGMQVTGSWATARAWNGMRWECYLCHRTFVQILITRASGRAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGL9</accession>
    <name>A0A4Q9PGL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_953141</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145294">
        <property type="protein sequence ID" value="TBU51676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGL9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="23470" checksum="FEFBE68105F87D48" modified="2019-07-31" version="1">MDVILPPPPPISRHIPVDVCENIIDQLYSAFNVSEQVEYVSALRRCALECKDWRVRSQMRLFVSVILHDIAALHKIAALPRLNMLRTRRVGGEETWYPRASQSGTGKPLQYLPLHCRFSLLPSPFTTITRLHMEWVTFYCFSDFLQGVSCVGEGVLCVTLGPLPAYYAARTDKSRAPAAHFSTKPPVLAPTLIPTRRGTLDPDHHHLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHV6</accession>
    <name>A0A4Q9PHV6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cation efflux family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_939851</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145243">
        <property type="protein sequence ID" value="TBU52626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHV6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHV6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="176"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="7">
        <location>
            <begin position="324"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="91"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="521" mass="56257" checksum="98534A09874A6A37" modified="2019-07-31" version="1">MLRRSAAYRAHSSLPCLSDSFNRTLRVPALVHIPQTLTTPSGACWRRRSRNTTDATRAIATSAFSRSRSPPSSPASLASLFLLPATHMSTLTTRRAHSTQSKGKGPERGTESHDHEHEHSHDAHSHTHSHTHTHSHGFFRSLVHRHDHSDDGHAKDPEQIVQALKGEGDRGSKITLVGLASNVVLTGAKGAAGWYMNSAALLADAGHCLGDLIGDFITLFSWRLSRQPPSEKYPYGYGKFEVLGTTVVSILLTGGALGIGLHSWTLLMEVLSTATVTMGPGPLHDVLARILDLAQAVPSMAAEHAHVHSHGHEGHGDGLLDPNAAWFAGVSVVAKEWLYRITKRVADEERSPVLLANAVHHRSDAFGSAVAFVAILGNWWFPHLPLDPIGGLIVSVLIFQQGWGLLKTAFRQLTDAGVSPTTKAVLFDALRPLLPSSSPPDATLSDGQSRPATQTLLGISDLRAMRTGANMFVDLTAHVPAQLSVGEATAVEKRIHEALVKVRRDVKEVRVRFRAVASEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI20</accession>
    <name>A0A4Q9PI20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_141529</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145211">
        <property type="protein sequence ID" value="TBU53552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI20"/>
    <dbReference type="STRING" id="114155.A0A4Q9PI20"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU53552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="539" mass="60121" checksum="BB36C5748DE27098" modified="2019-07-31" version="1">MSSSPSVLLVHPPSYSNALLHIPPTSFLVLAITACCLYICGTCVYNLFLSPLAAVPGPWYAAVSDFWLTTHVARLQQCMTIQALFERYGPVVRVGPNKVVFCDLTTMRSVYCVHKFDKSPFYKALLTNNNDHAMTTLPHAEHAARRKAYAPHYNLPHLTQFQPDVNDSVIKVLNILENQQGKTSVSCPELFRHLMVDVISTTVFGSRSGALDNYAMGIRDVLSQAICDFPTRGIVRSFIPTSVWSIVCRLPSETWRRICNSDNTMAEFVRGHIEDTSARMQAAPIDHEKGDRIPLVQRMLQNRVNSAHDSLSVQNIVSECMGHLVAGVDTTTTLLSYLFWELSRRKDIMKHLQAELEEHMADRHVVPDFATLCKMPYLNAFIKEGMRVYGPAPSLLERVVPSTTASKIDDGFDMMGYALPPGTVVGTQAWSMHRDSEVFPSPETFLPERWLSVEGTAGEDERLNRMSQHLMPFGVGSRVCGGQNLAQIVLRVAVAAIACNFDISANSSETNEHTMRIKDAFVIHPATKECKLTFALRKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJJ2</accession>
    <name>A0A4Q9PJJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_936372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJJ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="12744" checksum="D61D271FADDDCF15" modified="2019-07-31" version="1">MLRGARASVLAPLQYAALATGTGARTQCAASHHLCQRCHVHLSKATAPTHLCSEVVPIQNLGVQAQAIATAVLAAFPAASPRDEMIWEPHLLGHGPMILKASYQASSVTRINKVWALSPCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJS1</accession>
    <name>A0A4Q9PJS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1041813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJS1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJS1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="1">
        <location>
            <begin position="202"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="576" mass="63820" checksum="AA66774ACB6FC492" modified="2019-07-31" version="1">MVFIIGHPRPFRWSEVKHITSYEDMKSTAYEGLVETFGHVFEWDEDCVPAELCQRWRETGDPVCDDALREVFASPSASVGQDLLDAVQDYAEATSREEAPATHAFLDEVLHNPPEGLSATDDEVAVARQFFIDDSVQIIQALLHYSLAGGLARFVRYPSALLSILIVVSLQSPRIVRTLGAVSYLVPHTKKTGSELPLSLMEAVSQITKESTDRTFMRLVETMQFILDVMGCTNPTPSSDDSSDNHLASLLPEGEGWRSSVRVRLLHGIARWRVKARWEREGRTDVLDSVPLSQEEVAATLAAFSTIPIWCLQRLHLPPSPDKASAYLALWRHVGYYMGVSPSILLRYFTATSAADKFTATAALNLFFEDIPELPANAPSHSAIKGPTIPILVAVSNRPPLHTSLEYNIALTTHLVGTRLARRLGLPPTRLSMRLKMHAFLLVQRIPHYFAAWYPRKAWLEKRRAVLAEGMMRSVRWNMGLRRSTFRPRTAVHDTDVSGEAERAVDISAGGELAPGVAEAEAVQRDPVRAQVLTRQWKEVLYEMAGVSIAVGALACVALYLGAKCTLTAASILLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJT8</accession>
    <name>A0A4Q9PJT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDE Tnp4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_828267</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJT8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="22111" checksum="B8DC911227F7214C" modified="2019-07-31" version="1" fragment="single">PSFLPHVLHVYKHERPDLFRGHLRVNPATFDRLVARLQGDAVFSNDSENAQISVEEQVAITLYRFGHFGNAAGLQKVAEWAGYGKGTVDLVTRRVMTAVLRPDFLAEAICLPTQEEKEKAKAWVEKHSCKAWRNGWCMVDGTLVPLDERPFWYGESYFDRKCNYSLNVQVCACIPLCVIMISIFPDCLPAEPSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL92</accession>
    <name>A0A4Q9PL92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA polymerase beta</fullName>
            <ecNumber evidence="6">2.7.7.7</ecNumber>
            <ecNumber evidence="7">4.2.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="24">5'-deoxyribose-phosphate lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">AP lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">DNA polymerase lambda</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">BD310DRAFT_826872</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33 34">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="28">Repair polymerase that plays a key role in base-excision repair. During this process, the damaged base is excised by specific DNA glycosylases, the DNA backbone is nicked at the abasic site by an apurinic/apyrimidic (AP) endonuclease, and POLB removes 5'-deoxyribose-phosphate from the preincised AP site acting as a 5'-deoxyribose-phosphate lyase (5'-dRP lyase); through its DNA polymerase activity, it adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. It is also able to cleave sugar-phosphate bonds 3' to an intact AP site, acting as an AP lyase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="29">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>a 5'-end 2'-deoxyribose-2'-deoxyribonucleotide-DNA = (2E,4S)-4-hydroxypenten-2-al-5-phosphate + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:76255"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:18657"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:195194"/>
            <dbReference type="ChEBI" id="CHEBI:195195"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="6"/>
    <dbReference type="EC" id="4.2.99.18" evidence="7"/>
    <dbReference type="EMBL" id="ML145178">
        <property type="protein sequence ID" value="TBU54960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL92"/>
    <dbReference type="STRING" id="114155.A0A4Q9PL92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="21" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0235">DNA replication</keyword>
    <keyword evidence="11" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="18" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="22" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0488">Methylation</keyword>
    <keyword evidence="13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="23" id="KW-0539">Nucleus</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0915">Sodium</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="BRCT" evidence="32">
        <location>
            <begin position="136"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="406"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="31">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="30">
        <location>
            <position position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00020020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00035717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00035726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00044678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00045548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="TBU54960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="787" mass="87572" checksum="7711D42E3E3C0FF9" modified="2019-07-31" version="1">MSSARALGSSEARTEASGSRVRVPQDPTASKRTARTKPFEVPQGVKHHAPIADSSNITSPTSTAPGVANPATAKGAVEKKGKVTVVAKQATAKRGATSAQKPKGKGKRRELITASEYAKMKNAEAEERRLNGRMPAAKQFLEGKRIFYYGADLNYAGEDTQRRMDIIIKHGGTLIPDYDPDQITHIVVSKNTGAKALLKVIGLRRLKDIPQRIPTVTWDWIQTGFSAPRDRIDVADEDDPLVYKMGWLFEYAAYSERIDAGETPWGEYMAGRKNLSTVEGPSGVNGGRSTDVFPTSDVVDDSSHISDFTQDKVLPGDGVQIMPYAGLPSPPSSPSYPSLGTLLPHYTKVAGKVVQAVQSISGNGGSWQDTAVHAENHVVDPAMRYAEDPLAEFYAQARAERNAEMFGHDESDSESITPEKEQISRTRHRKREAVKKGVFICDDKGGKRRQATCPNQDVIDKLEELKALHDVKPGEDDRWRVYGLNKAIAALRRCPTRIRTLEEAMKLNGVGEKTARKIIEIIQTGDLMRIQYETTEDIKAVKEFTGIYGVGANTARTWFNNGCRTLEDIAARKGGVKLSHAQEIGLRYYRDINTRIPRAEVQEIYDKIKGEALKLDPKLFIQVMGSFRRGKSTCGDIDILISRPVDDGKTHQGILRRLLAELHRQDIVTEDLCLPDNFEDLELVYRGLCRKGPGSLRRRIDFLTVPWVSRGAALLYYTGDDIFNRSLRLKANKMGYSLNQRGLYADVIRNKDRQKVTEGVLVASESEREILDILGVPWQEPHERVRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLI8</accession>
    <name>A0A4Q9PLI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_711795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLI8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020475209" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="15674" checksum="CFAE0DCBEB7FCBED" modified="2019-07-31" version="1">MAPFFASPIALTHAVALSLRILTCDTHKLPYSSSHPMLPIRPPYPSITRLLRYPRYVPLAIPHILLFHPYVINQCFVHNISLFCHVLVSWSLSYVRFALVDSSKTCYRVGSFARYLSHLFPQSCPALSFSSNHNVICV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLN8</accession>
    <name>A0A4Q9PLN8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_714581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLN8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="168" mass="17734" checksum="3EE83A17AEA8B294" modified="2019-07-31" version="1">MDQLEPGVIVGGVIVLVVITSMLVATVVVVWRSRPAAIAARARKQRERSRTLVHEANGKHIAPLPFESPSSPASDTIMENKECGDQSFTASTTGSDTDTQSLPSPPPKSVLPHVGHSVPSALNVILAPRLLQCVEKGEGLDEGQILEKPPPAALGSLPSASGSAWWFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLV8</accession>
    <name>A0A4Q9PLV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_826662</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLV8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434:SF1">
        <property type="entry name" value="CUPIN TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40434">
        <property type="entry name" value="CUPIN_2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10428" checksum="63A7392A1CDD6B61" modified="2019-07-31" version="1">MTSITQHHAEQKVRSWGFSTVYTWTDGPNAHYHPHSHDGLTTHLILSGDFTVCYPEDALGKMETFGPGARIDVPAGKVHEVWMGKEGCTYVIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM70</accession>
    <name>A0A4Q9PM70_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_826137</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PM70"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="691"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1212"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1166"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1172"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1340" mass="147009" checksum="B3E03BA4455CDD68" modified="2019-07-31" version="1">MPPKLNPFSHRLRNSFADMRTSSAHHSQSHMEHPRIPITPADATATAAAIRLAAARVSVAPLALPSPEHELTDPMRGVTAMIPGSHPDVFAHNEIVPLLSPNTLRKSRLSSFWQGTQDVDDGTSPTHSSTSSNTTATGGPVDGTEGREADGTTDGVPLLPSKNGSEPQPESRRSSNSSSSTSVPVPMVRANLPPPATAPAPTAAEPPDDDYFGNADSSRYSSFSQSDRSTVPALPAPPVPRVVGDPSRQTSAPPFVFDPQSAPALPRRICLTRQTSAPLPTAPLYERRLKATRLAKESQLNNLAGRAAKEEQMFLELGYLAPPNPPNELERRRALYKYNIWGTGPDPNFDRIAHLVKLVFNTRIVIMSLIDGTEQFLKSESGMGCVSMPRSSSLCAHAILQPDDEPTIVLDAQEDWRFSQNPLVIGHPRIRFYAGCPLRTQEGYNIGTLAIMDDTPRREFSPRQRHTLKEFAQVAMREMELWKDKIQLRIRDRIQSSMEQFTRECLEVDKHVNDEKPEMPQPGSTSMEQIYTRAAKLVKRTLDVEGAIVMDVSHVDVLETVGAESSVSLTLHDADSRSESRSRSLSKEEHRKLAEFFMKHPEGKVCEGIVHPSLKPFLPARIQYVLAVPIYNIDKRPFALLCAYSTGERTTPFLEGHELSYLRAIGVIILSAVLKRRMILADKAKSLFISNISHELRTPLHGILASAELLAETPLDHSQASFLQTVQACGTSLVETVNHVLDFTKLSGNAKAGGVENIIHLSRVNLMQLIEEATEGCWIGHRARMFTSEIGSVYSPPKHQHTSSVPNRNKHVETVIDIGHSDSGWTFRCEKGGIRRVLMNVFGNSLKFTSDGYVHVLLRQLPNSGDTPPGKVKIELAVLDTGKGISQHFLKNQLFHPFSQENPLQTGTGLGLAIVNSIVRSPSVGGKVDVWSVEGVGTEIKVTFTAEAVESPSDSASPYAELAKLLDHTHKPTISLLAFDETIRGVQLLRKVLVQYIVNDWHLPLAEDGEMGDIVIVNEDPTPVTLAIEKKDASRPFIILSSARGDPRLMAIVNEYEHVGGFCRIVYKPVGPCRLVAALKLSLHALNIGKSSLTSTSTSTIVRPGSPSRSNSFDRPEPIPLPRRYSEETNGEDLFKPLAQRPPLGPRAVTAHPLTSWQYMPSMVEQEELEPESTLSSPQLSQMPSSPTISVGTGGTLLKSSIGTIAPQGALRVLVVEDNSILRNLLIKWLRNMGYEYREAVDGQEGVQTFESNGPFDVVLLDLSMPVLDGVGATARMREIESKRSQSNQSEPHPARILALTGMSSLEDKRRAFEAGVDGYLVKPVAFKTLDSMFQKLGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP58</accession>
    <name>A0A4Q9PP58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_883200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP58"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16531" checksum="AE299DDADBBF324F" modified="2019-07-31" version="1">MGFEGLWATRTLAPHKRPDKSQLASAEQASTDPLRERYGISNTLTYPQHGRSVDGHWENTGKNVSSIWWVIDERNLGVTTITVWVLSPRRLWVMGYWGPMGYGVEFPLSRLGKAKILWVFGVYGLPGVWVRRVSTVPTSFLVPVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPB7</accession>
    <name>A0A4Q9PPB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1040684</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="260" mass="28952" checksum="76DF484F0E4FC005" modified="2019-07-31" version="1">MSESAQGSAAAPRGRGRGRGKSRGGLGKYLRARGRGRGRGRPATFGQRLLLEGENAAELDEEEQKEYERELQQRYGRRQLGTNADRYVEPEPELDSEGEEIVEPEVDLSAILERQRISPGPSSAPPPDEDDDVDTSIVLPGKPHPHPKKGRIQQADWDEELEELSREKAAADAARDLKARFRAQTAKQRGRASPRGASTLGRSKQGVFSERVWLSFRDLDQWVRAERSHIVEAPPLPTAVPKPDKSEKEDMQGFLDDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPF7</accession>
    <name>A0A4Q9PPF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_960458</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPF7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="454" mass="51787" checksum="545B940F18C7C38E" modified="2019-07-31" version="1">MAPPNHHNRRNHRHPPPTLARSSKCRTLCDLPVEILYMIISHVEAMQNAWTMRVCTFVCHCLRAVSLEHHFGTRLAVRNIGTFDHLLSFLADNPKVCAKIEDLRMSGQTRNIKKDQYLPLTPIDDTVVFRLMQLLPNLKYLELSKFRFESPYTSAHQPTPHAQEDTPEPFHLQRLSLAHWSHTHYSFHHKSSTSALFRILSLFVVDLLDASWINYEFEASALDLAYLHRPLNVKELRLGSRPSADRFSTLKLLKAFQESLEPGALRILDAECRTVRDVPALGKLLARTGEGLTSLKVAGVAPYILQERKDWRDPLDSQWQSLNLTSCPKLESIKIDIFFRASSEDKQPTGGPVLSLAGAGILSQASGALRNITIRLHDLPRVTTLTNRRLLRLQAFENVITPKRFPLLQNVELLIKPEWNVERTTTCQWQHVVAEAQKALPKLHSRGLLQVTKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPH8</accession>
    <name>A0A4Q9PPH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_823993</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPH8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPH8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU56249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="550" mass="61779" checksum="1D1EAFDA449C903C" modified="2019-07-31" version="1">MSFYVPAALLVVGALLVLLRLFNRGGIKHIRGPPSPSFILGHEAAIAHQEEAGTLDTQWMKEYGPTWRVRGAFGTDVIMSADPKAIQHVFQKSGYNYPKKESQNFLGWLLAGPGIAAVRGQDHQRQRKIMNPAFSVPQLRSFLPLFQRIATKLSNKWKGELVATGELSLLLNKWLSRATLDVIGEAAFDYNYHSLDDGERSEISKAYENIFADMSYMPPKAAVLFQASWDYIPVPILKLIRYLPLNPWTRMRKLNNLFREYGKQILREQGPDVDTEKKVNSKDVMSILIKANHSADAKTRLDDEELSAEMFTLTLAGHETTSATLTFLLYELARHPEYQERMRQEIRDVRAKVAQRGGAEFATEDLDSLTLTNNAIKANCLMICLQETLRFHPIALGLARVALKDDVIPLAYPIVSTTGETIREIPVKAGQIFSASFIGYQRLTEVWGEDANEWNPDRFFRIDAVKQPANVGVFANLLTFSAGIRACIGWRFSVLEMQAFLSELVENFQFDLPKEKVDIQQAVAGIGMFPAIRGKADQGSAMPLRISLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ49</accession>
    <name>A0A4Q9PQ49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">snRNA-activating protein of 50kDa MW C terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_882645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ49"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="357" mass="39960" checksum="DFBCFDFDB60ED1B5" modified="2019-07-31" version="1">MHFNQDSVDDLRLMLEDTIRDPQLMGHIRRTHEATVHAIYETAEPIRKKRKRTTLADPGAEAPGVTALRLKHEAIHLRCWPLTIHAASFIRPTRQQDHNTLINVKSLGVGPTSAAGDHDALLSVTVYNRLSWGQKILSRASQHVLLSSQSLRDLFEAIPCTSKEIPHETRDETGTVTGYRSRRSGDDMAVDDDTGAVVCIEDVLYGDYQSEDDYADKVLRQLQSLPEEKRPSLPKGGPMHDTKLSSLTVRLNEPYWLLHAGSCEHFFTFTTIRLRHPSDPPVGYPLTTQITPPLCDNCRVCTKVPAVYSVVGDMRLGESPFLICGPCWRWMGNSSDESEVLVVPLPIYEIGWTGDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQE4</accession>
    <name>A0A4Q9PQE4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_931211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQE4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9700" checksum="6D67DC08DC69BE42" modified="2019-07-31" version="1" fragment="single">MWEVLANRMRTSARNLNGLSSVCAPVLPLGAITIGATRSLISYLLPVWADASFAFSFHRSSSTTTRRRMYILSQDEDSGGADEDHRPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQJ4</accession>
    <name>A0A4Q9PQJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_823394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQJ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQJ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="284"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="362" mass="40250" checksum="29E73ED93EDD4024" modified="2019-07-31" version="1">MDSAGDADVHRVWTLLSEVSEQLSQNRSSAVNLHALADGAKAQAIHSQTGFVLRRFNLDKPKEVYDAELERMNAAMSAENQALLNDNRQLSALIREYEQTLENVMATFRTRAHEVQRRELALMRQYESVLVERETEALDENMKVNTARSESLARVGRMLRAVLRRLGGEDVQLYEAHMAAAAGGKSAGQSRQPSTSAAPLSVRREERSGEGESSKKDKGKERDDGTLDEHRSGSPDPDIDHLLDEEEDPERRLAAAEWALERESELARLERENEELRALVNGLLKPEAPSSTAPQRPSELSSSTAPILIPDHPDGEEEGRNAEEHPSFATIPRQHRLLGGPPGTVGPFGTYKRNTLIRVDSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQQ3</accession>
    <name>A0A4Q9PQQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_823471</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF139">
        <property type="entry name" value="PHOSPHATE METABOLISM PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="663"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="708"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="821"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="901"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="60"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="342"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="613"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1040"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1172"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1335"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1204"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1242"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1363" mass="152619" checksum="4AE971DE921F5EE1" modified="2019-07-31" version="1">MATIQNRPFSKDYSGLINQSVVAGGILLVTITAHEIMRRKRRGKGPHDEGLGSVESWEFGYLYQGRSWAKRPSPPLPRKWPLGWIKQVLTFPEDRFNELRGVDASLYIRWLRGCFWFTGLQCLSTLAILFPIHVTFSDGTVSSKSMTRASISSLVTTPKGLSLLWVHIVLLVWITFTWFGTLYWICKGAFHYRAQKILAAANRAASDVQAERRAQYDPHPHPQYPFHALPPLDNDHTNRGLRLRTVMVTNIPHSLRSEKDLKEYFEYYLSRRVALPALGITSSTQPGFLNKTFAFLFNRARRIPTQVHLTRLSTGGSGGENSPGRSSPTQEPKPGENGPPAIDRVVLVRKMNDLASMLERREETLRLLETAHIKLARKALMDVQAAIQRQNSSPGMLRTAVRRMSVAAMRGSISGSLDVDAVNQSDDGTEEGEDRMQLLIRTLRPYLPALHTDLASDGRSSGWRRHFAKSNPDLEAAHTKVREKAPQVPDGKTVWDALLSLPRSTLDAYQPLIHLSSIFRGKTVPAIDYYTAKLQIVTNMISEKRSMPLTKFEPMSTAFVTFVDPADARRACKYLAVHPDNPLQCLVTMAPSYEDLDWTRLMKPTFRVEFVKDWVVELGVWAFTIFWVFPVTSFVALVNIQNLSTLWPGLLNFLSSHQWEEELLQSFVPTVLVSLLSLLIPLLLLLIAKRAHTIATLSALHDRIMTRYYKFLVVNVLVFFCVGTVALQSFLLSFKSVATSKVVNVIAQSFPVAAPFYVGWFIFTTAMHSGLEIALCNGRKFCDLPLILYPATRRQVTPRKRAMGIRPRTFNYYYWLPNHVLVMHVLLVFALLNPLVIPFALVYFAVERTVIKNQLLHVYAKNYEGNGQKLLIRMVRFSLDGLILAQVVFLAYMVVNKKTVNVGISAVLIIITAAYKMFLTRLCRARFEHDDELEAQIVCGTGQATEDLIDEAAPTNSEAGRSDLEARLSGNSMGNVWPWRLPLKINFAYTSIARRPHNSPRHLPNPFGPVRRSSSTVPLTLASPVEESPAIRPMLETCREVSNGGESQADQEQTDPAVVSKHPPHPAWEDESSPNHTYDNPYYTRHIENLLWLPRNPLGILNLDDTVDLRISLTTQPAAGRLTAWRDQEFLESGFSLPLAAASFASDDEDAESVHPSFYKRLDGSEEIQLPPLIASRISSSNREDDVETAPVYRRQSKRRKSTHSTTGSTGSHIGLGRPSTYDVGSSPGYRSMSIGSAVSQASSRGAPSGPPSSLLPAGSHRRNRAASMDHELGMRRVRNYPSLGARSALSVIEGAPIRPSLAGQYSSGSAGSKIISVQEAVYGVAIAEEEDAVEDIRERDEEEEEQAQQPKSWLTSWMFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR43</accession>
    <name>A0A4Q9PR43_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1040233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR43"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="37740" checksum="9D3193A4655CFC22" modified="2019-07-31" version="1">MDCLPEELISYIFDFLHAEAALSSAMLVSQRWYMYGARNLHHTIDLCIGPSVTVNSCDVAVCFMKRLVSSPLSSAHLIRHLTLSGFAPLDIQELLLDILGRTTHLLSLNMHALHILQGGMHFPQEIFSSPTFLPNLVALNASSAPFSVSLVQTRQYVEALRVHEPMDDALLRRLLGSGFTQKAKLLELALSVDSTTAAIARVGILASALAGGPLCALALQFDMDRPKPVSWEEFEGLITEVGQRLQCLQNLRRLSIVTRPDPPIAVTASDRLTGDSRREMMTRQLAERLLTDSELSSLERIELRWHGWKIQDGKMVAVPRTQLMRGPHRWLFEAPGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS01</accession>
    <name>A0A4Q9PS01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_822055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS01"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21037">
        <property type="entry name" value="MLKL_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.20">
        <property type="entry name" value="Adaptor protein Cbl, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036537">
        <property type="entry name" value="Adaptor_Cbl_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059179">
        <property type="entry name" value="MLKL-like_MCAfunc"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="246" mass="27038" checksum="43C2F2539B903B51" modified="2019-07-31" version="1">MASAVFSKLRSVSTKPLHRVSALATKARAKVGPHLPRSSTVVAGIKVSFAVATTLAPSVPYMQGIVDAASKVKEHADAMKSNRKECKKIAALTEDLARGVLAATDDVNEEELDDPTRLNLALFEWKLQTIGEAMGQMRKENSFRRFFAKDEHAETLAEHRQTLQDAVSTFQVSPHSQDVGVRILIGQDLVLHAVGSPSRRLPTLSVARRPRSRWRDEPVIWTARRDCKGTVNRSPSTPVPVTDDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSD9</accession>
    <name>A0A4Q9PSD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_853296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSD9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF142">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="479" mass="50701" checksum="FF517F95F16CFC59" modified="2019-07-31" version="1">MATDEQSTVLGVVILARHGDREGFYQDPETYTASATSITPLGEEQEFQLGTTIRDLYFDPASPSFIQGIANASALFQQSQVQVRADAGGEGGVIFDSAVALTQGLWPPTPLQSTLLANGTNVTSPLSGYQYIPIESVEPNEDVSLEGFTDCNTFDDHTTSFYNSAAFATMNASVAQFLEKLGPYMDGRPVTLENMWNIFDYMNVQSIHNATFANALPNGFLPMARYLADWHEYNVFSDTSFNGIGNIAFRTMIPSVVTAMQRIANASDPLKLHYSAIAYKPFLSLFNMTGVVADGALPESIVNYAASVVLEVRQPASGSGSAPVVRFTFKNGTDDAYRAYPMRFPGWDGTGANAGADVPLATFVGAFAPAGVNTTLEWCNVCGQTQERGCATLFAGNGTGGVALGGHHDRISPVGAGFLGAGLAVAVFGLAVAALVFLGLLTVGRRGKGRSGRVSGRAAEKNDHVELGSAANSITKESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT79</accession>
    <name>A0A4Q9PT79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_928786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT79"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8667" checksum="DDC8093EE14C9BA8" modified="2019-07-31" version="1">MRDDSYSTGTDHLRRRRRRLIATRASVLRPRLERRHSLLLFVLSPDQSLLAWPQQGLEPRTSTMLHDKDRCNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW87</accession>
    <name>A0A4Q9PW87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1012262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW87"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="82"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="704" mass="80214" checksum="139D9313E7FC73FE" modified="2019-07-31" version="1">MVEAEVRAKFTRAINMHNLVPGFKIAECGERPDAWEPEDGEYKMKVDAAADQIIPIEFKRDTVALDPFDDRKENFGTSTDTRKMVHGQIISYAEFIIAVQQRVALFMFVVIGQQIRFVRWDRSGALVTRSFNYVENWRFLCEILWRISNCSVTDLGLDPTATQLYPDDADYQRMDADALPNDSDADDTERDLMPEELADDSKYVFTYVREMFAKSLNTTWPRYRVEVPHGTSTRAFLIAKPSFLANGMAGRGTRGYVAVDCESGEFVWLKDTWRAHYIIIDPEGDILQKLNDAKIVNVPTLVCHGDIAKQVTLTPDWWEAKNPPTSDRASSTEGDPSGAPSASTSTSTRTHAHSPSSLKRKRGDEKSGDGAPAPKTDWHDQCTLCHHQHYRLVEKEVARSLVEFKNGRQLLCVVSDCVYAHSKAATNPKTKLLHRDISGGNILILPKVSNEEDGSHFLKWTGILADWEMSKPLQNPLSRPRQPERTGTSQFLSIALLSRPKVVEICDELESFFYVIIYYAVRYLRSNLDGFALRHWINAFFNSVTNDTASIRRKVVAVQLSAFWISYDERLQFNSPMDETSESSPAQRPLPLAAVVPRRRFQKDPRRRYDDLKLSKIKYDSEDAKIVDPLEPTKKDYEYSKYVHKHKHMIHLLDDIAYEREWLSGDRTPDRLLEDCSPPARSEGPTVPASSASNTHNKPKLDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXN0</accession>
    <name>A0A4Q9PXN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_421707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXN0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8303" checksum="388A4BCBE87C21F3" modified="2019-07-31" version="1">MRLHIESQSLISHADRCLRMCKWQRAVSMEGPPRPRSQHPPSALKYVIYVMLVQSLTTSTGDWRNFACKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY04</accession>
    <name>A0A4Q9PY04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_414593</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY04"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020811961" evidence="1">
        <location>
            <begin position="26"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="247" mass="28438" checksum="C0A45D7ACF0409B9" modified="2019-07-31" version="1">MPRWFRLHILCLAVLFQILPPPISPITPTLSRMPSQLRIDLAWSALRAAVLAPFYLTPAFYHPLNIRICTTQHLLRHLTSPRSLGQHRSTTYLPSLRTKKASTAARLRPPREVLRWTQLCVIGKHIYASQGPKVQWYVCAISALLFDRISSPYILSLFLSPRARPCLGTFLVRPGSCTLFIFWPCFHMILALLRPTSALPSASDRPKHSTRTRTQRRSYSWVYGQYGHGTDERGRLRRARGRNNIEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYX5</accession>
    <name>A0A4Q9PYX5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1006729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYX5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="315" mass="34742" checksum="01F4CE4623EA0F8D" modified="2019-07-31" version="1">MPPKKEFYCDCRQYCRSQRRQVSRTTYYNHAHYRNLPLLQALRLALGASDSAEPTGIQSTHTRSTKRHRTQRRGQQRVAGSSSSAGTHAGADLQGASGNAELEPPGSQPVQADPRESIPQPPVGTEHSSVEEPESGTHGAAGSLPKPTSEEPKHATAVIERMRHPRRHGDLPDLTPPERSQQLALWLSNSLPFSLSLSLSVALVFLSRQPHISGTTTDPRASPNLGNIYFRPTFPCHTRLPSNFLPLWTIALITQLSHQHMGHGLPHRTRVARTPLWRSSNSQYDFNASNKSFRSFGTYPSSTCLAAIPVLTKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZD6</accession>
    <name>A0A4Q9PZD6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924024</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZD6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="114" mass="12334" checksum="D93C9A60F16D9D37" modified="2019-07-31" version="1">MMVATPKRTWGRQLNCGQQDHESEGRSSSGGTSAILRDDAKIASRSSSRTVPSKCTLTSPDKIKNDHKQPSVMEARGSLPLQDDDRAWTPSTPDASRPSSNLTTLPVDPFNPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZH3</accession>
    <name>A0A4Q9PZH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1006978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="13182" checksum="35F4789A26F55CBA" modified="2019-07-31" version="1">MMSSPPCLCPMCVSAPALMPGKDSQHPFYPALEQAIEVLEDATAKENWEVREKSLAGYARLFRTPVTRSPSFSDLLSCIKAPRTCEGRLSAAKAPRCRLLTGRLPSTERRAGDAHDAPHAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZY1</accession>
    <name>A0A4Q9PZY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_922930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZY1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7450" checksum="4A16AD5C998350D1" modified="2019-07-31" version="1">MQAEQVATQSTACHCASPALNHPLQNPHLSTPRLHPPFITRYNVPVLQHAPWALMFVSHAKTAVATNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q049</accession>
    <name>A0A4Q9Q049_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="15">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_922563</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Endoplasmic reticulum membrane</location>
            <topology evidence="2 15">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Microsome membrane</location>
            <topology evidence="15">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the SFH5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q049"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q049"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11 15" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 15" id="KW-0492">Microsome</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="17">
        <location>
            <begin position="217"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU60473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="392" mass="42579" checksum="B9B43AF672AF6532" modified="2019-07-31" version="1">MMSSENTEPIPVPPPTEPIVATEAAAEPEPTASADAPAPEPTPAAPSTDAPAPAPEPEAVPAAPAPEPTPAPTEPTPAPAETTPAAEPTAAAAPVTEAATKPEDPKPAEPSVVTETVKKEEEVEEPQNELTKKFTEAEWKAVKELRSQLPSVFERAYPDAKPAPSSITLWGVELSPTAPSAKASVILVKFARARNLVVKDAADMLVNTLKWRDEFKIDEVLKEQFDPEVFGKLGRVYGKDKQGRPVTYNLYGAVTDLKAVFGDVQKFIRWRVQFMEQSIELLDFETVDQMVQIHDYEGVSLTQRDAAQKAAAKEATNIFQNHYPEFLSRKFFINVPTLLTWVFWLFKPLLSAATLAKMSVVGSGPKTIGAELSQVIDPKELPKKYGGEAEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0Q9</accession>
    <name>A0A4Q9Q0Q9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="9">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="9">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">PAN2</name>
        <name evidence="11" type="ORF">BD310DRAFT_957468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="9"/>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0Q9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0Q9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 9 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1070"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1129"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1087"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1139"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="875"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="877"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="984"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1037"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU60625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1152" mass="128589" checksum="305CBD845F7C9562" modified="2019-07-31" version="1">MSTTYHQIPSLAYQRDISPQPITALSFDPVSDILWSGTNSGHVCANYTPRGLRGVHYPVGGHLAVKKILATDSNIIASGLASEGIGAWGKGGINSWYFKAGGHITTFSNKASNASTIAVSTASSELILLNTQTGSVLRRSPSSSILTHLHFTASQTYFVSGDADGWIRLHDPRDATIRSYGSSPVKAHLSGIQGIETTSTLLYTIGLGLRQGRPYPDHLVKVYDLRNLKALPPIPFSSGPSFITRLPNRPSTLAITSSQGLVQIVDTSNPTANEFYQLDTPSYITSVAVSPTAVYMAFGDSDGAIHLLSAAEEEAMVPFNGFDGKAIDWPDSPEPLPEIQWTDRTPLNTIGLPYYDNLLLSSWTNDFVPTNMYFPPAPKIPAQILSSIKVNDSIAYASLPKELRGRRNVVATAPRKTGGRFRSGKARYNDSEPVTPTYEYNPDIIPKAYRKVEIEYSKFGVEDFDFGFYNRTPFSGLETHILNSYTNPLVQVMHYALPIRRLAKSHITTDCPREHCLLCELGFVTRMLEDARGTNCQSSNFCKTVGVLAQMNNAIELIDYGKESAELSYAHMIQLFHRFLIDHLSSEGNSFPHNPSLLPNSGPADLLSPAPAPITQLLGIDAKNIIVCTSCHAVREKENMTHLIDMTYPVRKPPNNDPAQETDFASIVRNSLLRQTMHKATCQMCKHFATFESRRSIRTRDLPPLLAINAAVHNEETHKFWRDQRKQTFLRPRIELRGQIEGMDDPETVVYELRAMVAQVVAKDANSHLVAIVKVPEAEESDPEPWFIFNDFMVQNITEEEALSIPSSWKVPTVLYLERVDVHQRLDFSELPDKMDPSILCRDTNIAMNRDPRLIRHEPLRFEELPTPGTLIAIDAEFVSMQQEETEYRSDGTKKVIRPARLSLARVSVLRGDGPKEGVPFIDDHIHTSEIIVDYLTEFSGIKFGDLDPSLTGYTLTPLKVVYKKLRLLVDSGCIFIGHGLSKDFRIINIFVPPDQVIDTVDLYYLEHRQRRLSLRFLTWFVLKENIQTDTHDSIEDALSALKLYKVHLQLEADGTFDKKLEELYREGRQYNFKPPVPPGTQQTSSPAPPSGPATPTPMPHMGMGRGAFLPQQQFGGLGGGRYPLNAVATPPFFPTPGHTRNYNTNQNWRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q156</accession>
    <name>A0A4Q9Q156_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_921698</name>
        <name evidence="8" type="ORF">BD311DRAFT_754306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143404">
        <property type="protein sequence ID" value="TBU30746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q156"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q156"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF56">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="737"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="741"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU30746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="875" mass="97722" checksum="DCBAC8501958820C" modified="2019-07-31" version="1">MSMSSDSPMLPPPDLSPKEPVNGEKKRKRGATRLSCAECRRLKLRCDRAVPCSSCVKRGCAAICPDGSLTTGKGNRFVLASTQDLHEKINQLANRVRELEDALRASHTLHSMEPHPLLSDDLLRIKAPIQRENLINTGTSNGNAEEPGADVVDSFGSLAISDTGRTNYFGQATSSWYFLTNEENKDDDRDQRSANLRKLLSPEVLSLSGLFPIAPSLPLTLDAETLRIERLRSLFWYLPPVDEATELQKIYYQHAAWMYNPVSPAQFHETAFNQFYNPNISPQMDDPLMSHQLALLFMVLAIGSLMDIKRPAYNIEAEKYHQLSRAALFQSPIFEEPTLAAVQTLYLMAFYLFLSERHGSGVGSRWAFMGLAVKLGVSMGLHRDAGRWKVDEAEIQRRRESFWELYSYDLLQSFTLGRPPSFTLVHIDCKKPYTEDPCNDETFHWWKHRFTSECMNLVYDQAFGAKTPTYGTVLQLDRKLRGFTVPPSLQIAGFGNSESRVGQYYESVPLILQRHLVLAIRESNLLYMHRGFFARAISDHPKDPLGSPYGGSFIAAYRSAGSLVALVRNIHSQLKELTERMWFLWTHLFSCSIILGSIVTRCPSMSLAPSALIQLDSACDLFSKTAKFFHAEKVLGIMLRLHDKAHASLAAYRNTPPTRAGTFSEPSTPADDDDELTILGGRTRLVEQKEKSMSPQITDRSPTSMNPVVPLPLKQPDEQSVHPYVLQYLRTFVPSPPNGTSSLGAGSSHSLSSQPAGIQNGVPVSPTHYQPHQTHNMQNLQPISTSFASPDAFQHQQQPQQQQQLPGLQMEGLQPMFPQYFPVFDYGHVGGGGASEMFATSPVPMDGDYGGGRSYSPENTMQTAWSDFVAQMGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1G7</accession>
    <name>A0A4Q9Q1G7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_847719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1G7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1G7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="504"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="574" mass="64674" checksum="F6372FFC3FB34D71" modified="2019-07-31" version="1">MNPTFNGQAQWLLNALLTHLHLQRRQPQGPPAHMAMNFPQMVPLQPVGLPNALPPWIQQAALQQWFQQQLQAMGLIPQQYPPPIAGSVQGQLLQDILDAIQMQLGDLKNVKKEDMGDLDPADLQAIVHAIKKRWQDGSVARLQIFDELSIGSDRTAIDWMRMFIANMDKVFAQVDADTSSGPTNDAAPATSAGGSLVSDVRESQGDIARHNIVTRSKTGFSTPKRAAHESLRYELLPVRSPPSAETSKKEGQEPIFHDVTFIPPSDGPEKPRLPRFCSSAADPSDKFTDDEKVFFVHWLRWRLRQEPLPDKDELCEELQTELPHRTASMWKSHWEDHPELPNQIYLAAKERAEKEANWRIFPTKVAALNEPLFLESESEDDGDDGRSDPSYSDRNGPTPTLSPLPRARKSKHNVSEAELRAMALYKFEHATKWENNTRKYPLWRDFANRPENIHKRTSEEWRGIAMNRKYANIIRRYVEEHRAHANVAKDVKTMSANKDAVTHSALPASSNSAASPVGPATQLEGGKRTKRPADLGGTSKDWTEEDQLSPKRTKMSLAPKKIPVVWIDLTDDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q211</accession>
    <name>A0A4Q9Q211_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_921889</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q211"/>
    <dbReference type="OMA" id="KTHCRDM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="154" mass="17458" checksum="74D720C5C3865549" modified="2019-07-31" version="1">MADSSVTDPQVAADLKKKRTFRTFSYRGVELDKLLDLSNEEFVEIVHARARRRFQRGLKRKPMGLIKKLRKAKKEAPPNEKPAVVKTHLRDMIIVPEMIGSVVGIYNGKVFNSVEIKPEMVGHYLAEFSCSYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2M6</accession>
    <name>A0A4Q9Q2M6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_921492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2M6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2M6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14342" checksum="4630A67FA26FE8F8" modified="2019-07-31" version="1">MHTRPESGIDTELAEDLERNFTWVPPMTIEGAEGEVSLEGPESTSVEDLEKAFKEFEEQLAAERGQDQVEGAGSDSQQSGEVLKGEVYNFEELDKVDKGVIPMAVEEEVQIIGDGGDNGAGWTVAQLTGRAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3X4</accession>
    <name>A0A4Q9Q3X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3X4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9600" checksum="14CA373632CA3E64" modified="2019-07-31" version="1">MGIQSIIQARDPPDFSLATSSSRLLQYTHTDAEDKCGSSKGWRQIFRGSSREDLPGPKKTRRLENSNLPGMARHPSLDLPGIARHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q452</accession>
    <name>A0A4Q9Q452_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_813278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q452"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q452"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="386" mass="39586" checksum="1634C5A2A81825A9" modified="2019-07-31" version="1">MLTKASPRSPNGAIYFITNGPDENMVVSAAINADGTLRLDRAVASGGRGLHGHTANGNTGADGLFSQGSVQVSSKKNLLATVNAGSNTISLFSIDPRRPTILTPLGDPISSEGEFPQSVAFSSDGSRLCALNGGAINGVNCFSVDSKLGLVTLPNTLRYLGLNQTNPPNGPPGTLSQIHFSEDDSKLVVSYKGATGPGFLATWDVAKDGSLAANYTQVNVPGAMVPFSLTPIPGENAFLLTDPGIGFDVVDFSGKGRGSANTVPGNGATCWSTHSTKTGNYYTVDVAANTIREVQLDSNLKPRVVASYTVANGTSPIDPEVATVGGKDYLYVLGAASEVVDVFALSGPAKAKQIATVDVAGPARAAGLSLSPGSLQGMATYVRSGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4I0</accession>
    <name>A0A4Q9Q4I0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_811303</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4I0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4I0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057357">
        <property type="entry name" value="Znf-C2H2_ZFAND2A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF40">
        <property type="entry name" value="CDC48-ASSOCIATED UBIQUITIN-LIKE_ZINC FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25403">
        <property type="entry name" value="zf-C2H2_ZFAND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="14"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="106"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="260" mass="27976" checksum="162E464F0C1A1932" modified="2019-07-31" version="1">MSGSATPERDVQLLEVGKQCSDPTCLLVDFLPFKCQHCAQPFCGEHFLPTAHHCAQYDAAKHDRVVPSCPLCNTPVAIPPGQDPNIRMERHINSECSVMTGRSGKANAAPHCARPKCGKVLFSPIRCDSCKQQFCPQHRFPKDHSCSTSRASVSRQQAATNTWANVQNQTSAASAAALAAIKRATATAPTAPRTHTQPKAQPPPSDAKSGSSSSSRSNPFSAADRCVISVAFIFSDSLTDVQSHYPVDDSIFPFHCSLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q695</accession>
    <name>A0A4Q9Q695_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat-containing domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_809809</name>
        <name evidence="4" type="ORF">BD311DRAFT_652509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q695"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q695"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="67"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU33573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="129" mass="13982" checksum="0050D678A7F2A027" modified="2019-07-31" version="1" fragment="single">RHYAASKSRIEIGKLLIARGADINARDKANQTPLHRAATTGSTGFINLLLNPPEGSPKTRLNTADRVGNTPLHLAMESAHAEAACLLIEAGADRERENLDGEMPEDLEGVGGQEQRRAKAYVIERCGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9E0</accession>
    <name>A0A4Q9Q9E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar transporter chaperone 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1035898</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9E0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9E0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13776" checksum="65F7FDF2A4ACAE76" modified="2019-07-31" version="1">MSTQPLLQRTAAKRIALPVKIEPKVAFANERTFLSWLHFTVVLGGLAVGLLNFGDKVGKISAAMFSFVAMGVMVYALWTYHWRAASIRRGGRGPYDDRVGPTILCVALLVAIVVNFVLRFTQPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9F7</accession>
    <name>A0A4Q9Q9F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_470427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9F7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9F7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13525" checksum="40860B5FC29869CF" modified="2019-07-31" version="1">MAKLCLIGRLGKEPELRYTKSNKEYVSYVVATQNPPIADAEPTTTWHYVLSFLPNANNYLRSLKKGSLVYVEANYELRQPDPNADPNTPEGQRQIFLRHENIRVLRQPHGSREDADAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9I8</accession>
    <name>A0A4Q9Q9I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_470555</name>
        <name evidence="3" type="ORF">BD311DRAFT_655442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9I8"/>
    <dbReference type="OrthoDB" id="3259878at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU32005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="246" mass="27384" checksum="E0942F7489050C53" modified="2019-07-31" version="1">MPHRRKSRAHSRYLTAYDEFHGVAPRLNRLPQRLDYTLIPAPLDLSKPLVDEKSELPAIIVTPSSPVFESKFFIAFIAPPPSPTFSQRLSSLVPSFRSYLPSQIQLPQTPFKTTFNDGNNSFSLRGRIRTIILLFLLLFIMASHVVIHRIATNHPHLQFGIIPDNDIDVSSLSHTGNMDVFGVGGRADAQDTTEEPSTAGFWNLRALWAPTGATSSRSFIVVEELAPKEGNDNDTPKEEVRPEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9S0</accession>
    <name>A0A4Q9Q9S0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_916214</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9S0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9S0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="56"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="744"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="174"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU63384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="783" mass="86128" checksum="774329D0D1FF8311" modified="2019-07-31" version="1">MAKKKGKGSKGKGSGGRDDSAWARTDVIERQHMHNERLEKYYKAQNILPDEEWEPFLNAMRDPLPTTFRVAGSRQAARLLNDIIKDVHVPHLGDVVFEGEAVSPPQQIPWYPDGLAWQFNVAKKVLRKSPEFKKFHSFLVFETEVGNVSRQEAVSMLPPLFLEVEPHHRAMDMCAAPGSKTAQLLEALHAHDTITASSIPSGLLIANDSDYKRTHLLIHQSARLPSPALMVTNLDASIFPAIKIPSELTTFSADTKARVAAKKQYQLLFDRILCDVPCSGDGTLRKNPGIWKHWSPMDGNGLHSLQLRILQRAMRMLKKGGRIVYSTCSLNPVENEAVVAAALKSIPGFELVDMSNHLPGLVHRPGLTSWKPTVSKEINTEFATYQDYVQSLYDSQRASSKMFESHWPPSAEEAENLGLTRCLRIYPHLQNTGGFFIAILHKKPPVRAPPAPTKRTADAVEGLDTADAKKPKLDTEADAKDAEGQQADDADEELPEEAAGEPTSAMEIDQPISANAAPAEPKIRFKKGKTAEGASAHFKENPYTFIEPDDPIVKACIDSFDLSSDFPSSNMLVRNPAGDTVRSLYMVNDIVKSIVKHNDYARIRLMTSGTKVFGKQEGTEAKRDGVESHFRVLAEGLPVVLPFVGPRAVVHADFAALRVLMEAYYPLTSGFADPFRSTIEAKANGSYVVRFQPGKLEGATLAHELVLPIWKSNVSVTLMLDKRAKSALSLRIFGEDITSAARDAAARRNQKSEATPEVAVDASVQEDDNVDASDVVPGVVDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAA7</accession>
    <name>A0A4Q9QAA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_972913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9QAA7"/>
    <dbReference type="OMA" id="QPIYPRQ"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
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    </dbReference>
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        <property type="term" value="P:septin ring organization"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
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    </dbReference>
    <dbReference type="CDD" id="cd00160">
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        <property type="entry name" value="Related to CDC24-GTP/GDP exchange factor for Cdc42p"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
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    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
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    </dbReference>
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        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
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    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="638"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="796"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="957" mass="105695" checksum="CF3CECA31277BEB0" modified="2019-07-31" version="1">MANVAGRKKSMVASLPPSIDSPVANNTLLNKAASQSTSLYQQCSSLRTRLMHLQDFSDWFSVAAQPDSSRRSTDPVTQLWDVFALGVPLCYLYNLLPQSASSPIAVETDVLSFDRNNERTKKHAIALFAMNVKQVPGCEGFTVRDLWDRNSTDGFVKVVNNVINLVQQLPEDLFLESAPSSPALASALASTESLTSDNTLAASLMEPGGARANIIKELVDTERKYVQDLEVMQKYCDEAVSYLDRDTLHLLFPGLNKLLNFQRKFLIKVESIAELPWNDQRWGLPFTENEEEFAVYEPYCANYTMASEIMLQEEHNLTALNHIINVKGELPAFLIKPVQRICKYPLLLESLVKAVSNTDYPYIDELKAGVESAKRITDKINEAQRRAENDATVKNLEGRVEDWKGHHISNFGALLLDDIFSVTKSEVDREYHVFLFEKIILCCKEYIPQPGNGKKVGKSNSILKKPTSPSTVLGSTAAGSSSKKKNTPLLLKGRIFLNNVTQAVPKVSQGQYSLAVWWRGDDDLEFFTLRCRNEEQLKHWENQLNRLIKETANRRTSDRNIARLAQVANSTSPSPQIRSAHSSYAQERSSMFSNGSSGYASGVPQTASINGRMRHPYASGEHAVPSSSHPYTNGFAHVHQDYPHDGFEADQDDEYEDYPPASAGSPSGRGTPMGQSRRPDFPYPQSARHSGHATSPIMSGGVGGFQGPASARPVMSRNTNSYASDASFGNAPPPPRPGLRSQFSSTRLRSAYDGAESRGASPMPTPNMHQPMRSRSISQPQAYHPSPQQAPPPLPTSTRAEWSQGSLLSNKRGSGSSQSTDSADYSPHTSSSPITPYGSSESSLAGMSTGRSARGHIDQMPPPALKDELRLSPPVKIKVHFNEDIFVIQVPRSTEYYELVDKVGKKIRLCGPRRDDGPLRVKYKDEDGDLVSLGSTEDVQMAFESLRPGNQVTLYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBB0</accession>
    <name>A0A4Q9QBB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_397723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="297" mass="32507" checksum="EF3C126124421790" modified="2019-07-31" version="1">MILMLAMDPTYSYYQSPSNDSPTQQNARPHAYPRQPDQQQPSGSPPFSYTHTPTSLSGSGVQVSPLYHHGNASGYPQPHPSGYHHQHQQSMTSANALPPLVHAHAYSSRDVSRHDVPSGFAVPSLGPTLHDLPFAAARSSSSSSSGNRQSGNWGTAAHQPSRTPPLYDRQASYPPSRHGSHHPSLSHSTHLIPTPAQAAQSYHNYPAHTSPSPPLSAVMPVVAAIPPATSSSPPQERYYCDKCDKSFGRAHDKKRHFESTHLQQSHACRFCTKTFSRNDSLKRHQDNGCDKDPEFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC26</accession>
    <name>A0A4Q9QC26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_913489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC26"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC26"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="618"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="894" mass="97500" checksum="5C40D6CED5EFC394" modified="2019-07-31" version="1">MVETPPTLAVHRCRFVDFAPSAVTALAFPPLPLPSVKGKKAATSQGFPGFGLLAVGRANGNIELCEWTGPNPRSQAPQAWVVRKTLIGPYPSKVESLALTFRSSRRAAQEEVPSWSNLRLFSAGGGSELVEWDIEKGNIKRTLASQGGPIWSISPNPASTILALGCEDGAVRLVSLQYDELNHLRRLDRVKSRILSIAWGPPTPRQKKQPAANADSDSDDDEEDWLDSWLVTGCSDSSLRKWDFSTGRALDRMGTDKVRGERTLVWAVGVLGEGTIVSGDSMGIVKFWDSKTCTQLQSFQGHAADVLCLTVGPDGSVVYTSGVDQKVTQFSYVKTSRSSTDPSPLVSRATGRWVQSRSRRLHSHDVRALAIWPPYTPLPPSHQRHYPTDIAPVLVSGGLDMSVVTTPAALPTATLSGKIMNPLSTSTQATFEDAYHRRLAYSSGFSGTSAVHLARKARLVLCTREAGVTVWRLAKRKPRGDDLDLGADIPGQDRGWERVLDMDLNVQTNLVSGAVSDDGRWIAVSDWHETKLFQLSEEKNGDLKPKRIRDFSATLQSTLNGASTGASSLTFTPESSKLLLATSNSAIVLVVDLGSEGHSPRVLRKFEQHRIRDNVVKGRLVKGRQSSPAANGDSDVEMGLQNEGAPGADGAQASDDDSDLEDSRIVRTTITRMAVSPDGQWLATSDDRRRTHIFNLDAVQHHGSLPTFPQPVHALAFDPSAPSTLVLGFADNQLEVYDVEARQFPRWARSLVNGVPQRFTHLHDPVLGVTFDPGSGAEGEGSPLPPKTALFWGATWICKVMLTERIGYSGFEKRRRGKRKAPEASASADGRVEVSLEEGQQEVQQRNFKLVTHYRPLLFVDFVAPGELVVVERPLVDVLAKLPPAYFKPKYGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC28</accession>
    <name>A0A4Q9QC28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PCI-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_910986</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 19S cap proteasome complex which acts as a regulatory subunit of the 26S proteasome, involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome is composed of a core protease, known as the 20S proteasome, capped at one or both ends by the 19S regulatory complex (RC). The RC is composed of at least 18 different subunits in two subcomplexes, the base and the lid, which form the portions proximal and distal to the 20S proteolytic core, respectively. Component of the lid subcomplex of the 19S RC.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC28"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="189"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00093435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00093502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="385" mass="43654" checksum="1F99621239453D13" modified="2019-07-31" version="1">MAEDLVLPIPNLSLAQDYFVLSSPSLAHLHENARKSLLEGIQADQMAPYYRIVISTSALPLDQSLLDRMEKENKDELDKIEERLEEAKKTEGETDIADALRARANYLTRIGDKDKAIEAQKLALEKTPGLGSRIDIVLTLIRIGFFYGDHDLITQNLQQAEELVEKGGDWDRRNRLKVYRGLHLLSIRQFKRGGELLLDALSTFTATELISYNDFVASTIIANVLTLSRPDLKKKLIAAPEVIQVLPELPTLSDLMKNLYDSHYDKFFVALAALEQTHLKPNRLLAPHSRYYVREMRILAYNQLLESYRSLTLDSLARSFGVSIDFVDNELSRFIASGRLHCTIDKVNGVVETNRPSVKNAQYETVVRQGDILLNAVQRLSKVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC36</accession>
    <name>A0A4Q9QC36_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_942886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC36"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="499" mass="55485" checksum="B8FEE4EE7DA2E1A9" modified="2019-07-31" version="1">MLIGLDLKVGLVALCMIGFIFIFSLATTILPSLSENCPYRSPQAFAVFICVQGICWVGRAIARSAERFLWPSSADTTFGRKSDPEYGRASAPGSSVATGRSSFSRGPLSGGWLRSCAQSARTWLQRRGNKKSHWSWQEREEATLLSCRSTHEADLLDEYDSAKMDPVALQDVVRPCLLSLPLDASIGCFQRILIRRADAVDRRGLPDWDNDLDRDTCQVSVDILLDMLEREELSLSGPTPESGKRFQEHRVAHEQVLEVLQRLIFTRNHCTFLHERYERIFNVLLSYIRKPQYECVKKESNVQKSVFSILAYLGDKIPPNAVDREDIMTVVDYTRLARLYFGTASDASLLIARLAISMVLALPPTVSLCAEDIVDAVRDLVDIVIGDLKRMLADGTSPQGCASADFLPALHSFLSLFAALLGANAGFLTAGSWPKLRGLSRQLSSAYQEAHHTTYVDAEGRGTAQYLKLIDALYEGEAPPSPFGRPHSRILRPVRETLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCQ5</accession>
    <name>A0A4Q9QCQ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-binding protein RAP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_913744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Chromosome</location>
            <location evidence="5">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the RAP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCQ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCQ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070187">
        <property type="term" value="C:shelterin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031848">
        <property type="term" value="P:protection from non-homologous end joining at telomere"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11655">
        <property type="entry name" value="rap1_myb-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039595">
        <property type="entry name" value="TE2IP/Rap1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015010">
        <property type="entry name" value="TERF2IP_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466">
        <property type="entry name" value="TELOMERE REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16466:SF6">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 2-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08914">
        <property type="entry name" value="Myb_Rap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="TERF2-interacting telomeric protein 1 Myb" evidence="7">
        <location>
            <begin position="201"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="291"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="511" mass="57368" checksum="BDC740FBD32F59B4" modified="2019-07-31" version="1">MPIFQDANGMAVKFFIQKDIPQKTQAEVCETISALGGRVEPKVPRAGYVLVQPGTAEEERLRLCWSTADRPERYFVPYTYVEACKITGMLLKQIFIQDGQPIRMHIDSSIANVNVRAALATRIMHSGGDPTASAQSARVILADPNTEIFQHLVKTYQGEPDKYVESYLWVKKCIEKGQVIYTPVVYKNPGGRRPGEERTQFTERDEENLCSWIAAKIPYKETGGRTGNRLYQQLCEMANDPEYAWVTRHTWQSWRERYKKNATRLDAKIAEIVDQKKPAHGEKGQYGYVRKPEERPKRVRKKRNANGAEAASPIAGPSMHSMDTYSVPMPVPLPALSGVIGQVGGPDDAFNSVVYPSAASVFQHMPVSATGQHMDAATARSQAREEEMEDDEEWQIREGDAPPPVWAKRKLDEEEGPNKRSRLNSPEIAAGLHPIDQAVQDIAREFRFTTEEVQEYYDKCGDPERTRNRFKKMRDVLNALKDDEDEPASAPPATSTTPVPVPTPVPVSPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE29</accession>
    <name>A0A4Q9QE29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Nucleotide-diphospho-sugar transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_804680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE29"/>
    <dbReference type="STRING" id="114155.A0A4Q9QE29"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="252" mass="28861" checksum="3D3FE725F73E2B61" modified="2019-07-31" version="1">MLYIPEQVSPRGLCIASATGFHPHPVARIEPPDAGADVYPHFIDQYTKLRLWELDALGATGVVYLDADTLVLRNFDELFALPYRFAATGDVYTNRKGFVLGFNAGVLFLRPSTALFGEMLRRIPEADYWRHDAEQAFLNTFFAKDVVRLPYAYNANLAIKARAPRMWEGIKKEIRAIHYTMVKPFTKDNKNYALVPMHELEANARRRASEEGGVFVEEMEMWAQSWHRTYATHGEKLESCMALSNIPGQREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE68</accession>
    <name>A0A4Q9QE68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_804065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE68"/>
    <dbReference type="STRING" id="114155.A0A4Q9QE68"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU66107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="98" mass="11475" checksum="38AB13FEF533E0DE" modified="2019-07-31" version="1">MHPQLTEKKLGSHSPVQACILHVRLTNEFHAVCLEFIQALDACHADGWSRWTGGCNQAKQDLNMCLRKERVDRTTKNREQAKAKRERIEYAWKELRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K744</accession>
    <name>A0A4V2K744_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_935269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K744"/>
    <dbReference type="STRING" id="114155.A0A4V2K744"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10208">
        <property type="entry name" value="ASKHA_NBD_ScArp9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="493" mass="53619" checksum="FD8D13B19127E010" modified="2019-07-31" version="1">MSSTSFRDSTVVIIETGRTSIRAGQGLHDLLRLPTVDLPARVGLRRSLATPNVENGLSSSSAAVSAKVTDYLVGSQLDEALAAGQDLVISWPFAEGDISDYTQAEALWKYVLFSSLKLRRAQMESPVILSIASGLSRDAYERVCQIFFERFNAAGFAVLDRPMAQFYSVISGMQLSGIVVDVDRDHTDIAPVYDGLVVHAARTSVPLGLNDCLAYLAHLLRSNTSVMTALSPADKPLSPEALQETLLELATHIWQSDLIKALAEGEAARDLEDEGVTDIAAIVVAGKERAVIESGMKRRQAKAQPAEQARAKEMEALDLVSTEFRGIELTLGKERHRFCEPLFDPTLLDGVPGVREKGNRDLRRPLQNAVGDAVGRTDVDQRTYIWQGLFVTGEITNHIKGLGVALSGRLAPYILSAPDVPNNEVQPRNIRTLRVPDYFAEYRDKGDGLAAFLGTSIVAKLAFNDPAGKNYVSKPDYASRGPRTILGMSPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7K0</accession>
    <name>A0A4V2K7K0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_615261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7K0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="61"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="504"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU56368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="759" mass="80576" checksum="1BDCE5210A78B7D8" modified="2019-07-31" version="1">MTRLSCHLPSFLLAASLTNDFFVSGVIMSLEGLRRASGIATHGLATRAGVVDLQNSGDLEFYMNVTLGGRSIRVLMDSGSADFWVAGEIPEAAGTPHAVAIHYQDNTVGGQVNQSTLEIGGATIVNQTFVAQPVDTLHPDGQGILGIGPTSLSSIAAAIPAPAGNPVIDNLIALQGSGSEYVTTLISRPNNDSDVISTQLTVGEVLSDYEDVHVANRLDVSKSGWDSHWMVALDDGGIVSPDGKMVKASEGTQLKVVFDSGYTMAQVPSDVAEAIYSRVPGAKLTTIEASPSPAWTMPCNIELNVTFKFGGVSYPIHPLDTVMNDVTGPLDSNGVPSCVGAFQPSTSSTPYDILLGMTFLRNTYLLMNIGDQPYLQLLSLTNPAQAHEEFVQQRLGGVDTTGSQQLLPDTAGLSDISKPPTTVQKYKSFIIAGTVIGAFILLCVLGILTVWYRKRRYQRLHAPAPEGALQSRGPQSSAWKEFKEPEPKPRFKVLSLGLSGRSRSLTGAHGPLPDSYGQDSNASTRKKNAGDLVPNRRSKTQSMLAVARQPSFVEEGAALLGNAAVVGVTSPPASYSSHSSVYSQEDGPILVIGEKPLPNPHESETSASEERDVTSPRADDEEDRELPLITPAEYKRHTYGAVEPQTPATPRPPARADTPDPYDLPPLPATVPTPAPLPAKATHKHRPLPTPQPVARSSSKAQPLVLSAFESMSHRAAPGRSKMHTLPTLDISSTSLGMGSVTTSQSSKSSRSDSSNSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7W0</accession>
    <name>A0A4V2K7W0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_928746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7W0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9708" checksum="0D508B8D120E2AA3" modified="2019-07-31" version="1">MSSDLTEMTSIEKATIIHKRRLNATAPVSRLPNETLSIIFVRVVTALFERDGTCYSQNLPHAYPWLNITRVCHAWRALAYDTPSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8R6</accession>
    <name>A0A4V2K8R6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_256469</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8R6"/>
    <dbReference type="STRING" id="114155.A0A4V2K8R6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009653">
        <property type="term" value="P:anatomical structure morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050211">
        <property type="entry name" value="FOX_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829:SF343">
        <property type="entry name" value="FORK-HEAD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11829">
        <property type="entry name" value="FORKHEAD BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fork-head" evidence="4">
        <location>
            <begin position="269"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="2">
        <location>
            <begin position="269"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="366"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="465"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="466"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="484"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="570"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="831" mass="89621" checksum="D17DAF9577AE0E8F" modified="2019-07-31" version="1">MASRSQRPLAPFPSSHEVSVSETLSRLGMTREQFAAKQAELSSGLLCNQPFVPRPSAAAQQPSNGRHQLDSFDGGRSRSTSVSSSSSRNPSPAPPRTPARHDRPEGGPSRPRDQMEMILEEQYRKKVSRRRDSTSRSRDGERVFSTASHAVDRPSSSNWPPVTPHHYRYYSERVVGEASASKHASDSSDVPETPSRNRERGRFKVPPPRYNIPKTPSRHDVGSSLPTTPRSSSPPVVNLVSSPGPMRPDPPEEEHLPFILPPGPYSTAKPELSYAAIIGRAILSSPGHALALQDIYEYITTVFPYYRRGEPTWMNSVRHALSTMAVFRKERGRAEGKSLWAVYDCDLPCFEGGGFKKALCADMQNGVPPRRKRATEDGVEGPRSKRRKGNEQRSPAVPSPVKPPFFPHVMPNPNHQSYYEAAWLQQQQVPADVLFPPLPASSNFHRVVARAASIPVLDVPLMVPSDASTDGASTETEGDDDLTSSSSPIERPPSSSSLPDLVSSLSTSSSPTSSSHLSLPGDSSRDPSPAIAYVPPPVVGITDDIEGDPMAAWLRSDSPPPAITYLSQKAKGKAKAKSPRSSGKKQPRKMAAMHPPTSPTPERRGMAAASRRVSSSTKPRSPPKVGSSPFAPKPVTAQSVLHQLNESLVASAIAAEQDNEAEGVERPSTPDRIVTPPPPSTPLRVEDLEAELIDFSPFKSLTADIDHLFGTSLPFHSLQSPVFSARAPLLGMGSVDDFVAGTGDLAAAAAAIRSPAAPAPRTPKRSPFLSSTSAGLSVRIASPFGTPSRSSMRDPLHQFDDDLAQYFSSANDLFAAYTTLANSPTPSHRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9D3</accession>
    <name>A0A4V2K9D3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_916380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9D3"/>
    <dbReference type="SMR" id="A0A4V2K9D3"/>
    <dbReference type="STRING" id="114155.A0A4V2K9D3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="119"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="472" mass="50907" checksum="3C0239A6A09BC547" modified="2019-07-31" version="1">MSSAPKETPLVYAASCNPPRRAKRQRTGSLVGGEGQSQAAAASPTSSVAPFQQRRAPARPPILPKQPATGRGYADPASPNLDSGSDEEDDYDPGRDAAPAPKRRGRKPGTMSRSARESLRKLNHSRIEKARRTKINETLATLSTFVNERGRVLASQRPEAVVEVPAEENGKKAKGKTEEKEFKLDVLVKTVEYMQDLVARVQALEARMCSQCRSRGDNREDTSLPPSPKRKRADEDEAMVDVSPHVTRRSYQRHEEEDSYTGDDEHGLGAAEEEQPSPMPFAVPNAAAAQSNASPRLPPISSWLSHPYDPSTLISKSFNAVPARSPKNAQLPSPPPSGRFRPAITLANMPSLALPAPAHPLPPQKQASGSSTTARQQHRKSVSASPTVSPTWTPEDETAASLLLQMSVKPRSSSISSTSGGGSSVSSLPRSAMMPMTPREEVPMAKDRAFPAAQQQRSMEVVTPGSLLGMRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9E6</accession>
    <name>A0A4V2K9E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_808557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9E6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="17243" checksum="BB8F53123D73962B" modified="2019-07-31" version="1">MMWKFVHEAWFFKDRLSVVQGEAVPRHYGVWCGKAEWGAELAISIMQFGGYSYLRYFRDTALGKLSFERMRPCTRLELRSTTSRKRRSSSFTTGRRRKPSLSTSVMPMSNTSAARGSIWIQSYPGPLAGQFSFTCVKHTHPSCHRSEYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWT2</accession>
    <name>A0A4V6MWT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_948597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWT2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="40490" checksum="CBEBB981633B474A" modified="2019-07-31" version="1">MHHRNGRLERWLFDPRACSDLQSVLYAPQLPTVVDLWLSISPIAFQPGPLGKLATELLHIIFRMMSETGDVVCFALTCKYILSISKPHLLRVLKQEHAPWSGCRLIFIGSGTKDKGIPSGLICSEDLKQMKTAFGHLPHTHTFWTWNNTVVNKEDTRYLFAYTSDYYCPVMGSTARSDRKAWSDLHQRRLAELSGTSPNSESGKTKRLDLRRCELLTSLNYHVRPNRTWNDTTVLCNLSKGEYVRHAELTLLIKQDRRGAICMSLGLGQALLALICWTDSDNLTLVCHEKYRRRLLRGPWAGDKICITTSLEMPPLPEGKNEWINITKEIDGLMRHLWKNNVKGDWGLESDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MAG6</accession>
    <name>A0A4Q9MAG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">General amino acid permease 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_410408</name>
        <name evidence="9" type="ORF">BD311DRAFT_35585</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143485">
        <property type="protein sequence ID" value="TBU24194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MAG6"/>
    <dbReference type="STRING" id="114155.A0A4Q9MAG6"/>
    <dbReference type="OMA" id="WWAINIT"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="52"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU24194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="551" mass="60816" checksum="1162AD948F32D53F" modified="2019-07-31" version="1">MSEKRDSQEKTDGSSSLEKGAVHDYVVQQTDDRYHFDAADLDRVQRRLKQRHVQMIAIAGTLGTGLFLGSGHSLQAAGPLGALIAYAFVGTTAYASLCAIGEMTAHAPISGTFPHFAARWVDPALGFALGWNYFYTNAISVPVEISAAGLLLTFWDDNSKHQAGYIAAIVVCACAINIFGVRWFGESEFVFSIIKLSLITILIITGLVIDLGGAPNHQRLGFHYWKNPGPLNGADLTPSKPGLDKFLGILSVIVQAAFSFQGMELVAVAASETESPRRNISKAVRRVFWRILVFYLLGLLITGMIVPFNDPNLLSASGNAAESPYVIAMTRAGIKVLPHIINAGVFTSAFSAGNSFLFCASRVLYGLALRGQAPKIFTYCTKKGLPLLAVLASSAFSLLAFMTVSSGGETVFNWFQSLSAVGGFFGWWSMNLTYVYFYRGFKAQGLDRKKLLYWNPLQPYLAYWGIFWITIFILINGFTVFWNFNASSFLTSYINIPLFFILWIGYKVIKRTKVWKPEEMDFVTGIPTVEETEIPEEPPRTIGQKIFAIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9ME17</accession>
    <name>A0A4Q9ME17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_919297</name>
        <name evidence="9" type="ORF">BD311DRAFT_672524</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143488">
        <property type="protein sequence ID" value="TBU24076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9ME17"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040684011" evidence="7">
        <location>
            <begin position="19"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU24076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU62378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="593" mass="63200" checksum="0BE3B9E9D3373BCD" modified="2019-07-31" version="1">MLHKTGLVLAFSVASVLAALHQGPTAEVLNKDYDFVVVGAGAGGGVMASRLTEDPLTRVLLIEAGGSDFENLNISVPGRSSTLPMSAFDWNFTTMAQPGLNNRPVGYPRGFVLGGSTALNQMVFSRGTKDDYDRWANVTGDDGWSFKNLLPFIFAVDRMTAPVDHHNTTGQFNPAIHKNGVVPISVEGFPLEINSRVIDTTRELAEQFPFNLDYNSGNTIGFGWTQNTIHDGHRVTSASSYLAQAINRPNLDVVVNTRVTKVVSVGREQGKPVFRGVEIAQSADGPVHSLKAKKEVILSAGSLKTPHILMLSGIGDAAHLTALGIKPVVNLPAVGQNLQDHVFLGNSWVANSTNTLDDLHRNSTLAAEALALWKINGTGPLGLGAASQFGWLRVPNATGFFRSLGVEDPSAGETSAHFEQIPTNAFVSKTVPLPAEGHFFSIITAVVSPTARGNVTLNSTNPFDAPLINPNLLGSPVDVAIMREAVKAARAFVTAPTWSDYIVSEFGVFANATTDDELEVYIRKNSDTVDHPVGTVAMGQGTNAPLDSQLRVKGTVGLRVVDASAFPFIPSGHTQGPTYILAERAAHLVRSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MPW9</accession>
    <name>A0A4Q9MPW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="14">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_918673</name>
        <name evidence="19" type="ORF">BD311DRAFT_755771</name>
    </gene>
    <organism evidence="19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
            <strain evidence="19">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="14">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The histidine box domains are involved in binding the catalytic metal ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="14"/>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MPW9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MPW9"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14 15" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="3 14 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="335"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="303"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU29820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU62558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="427" mass="48292" checksum="A4F662F01EF1C5F5" modified="2019-07-31" version="1">MGASTDSDPMKPGSNAPREGIWWSNGLFFVATHIAAALGVWYHPPARAMPQSLWLAVFLWQAASMGVTVGYHRLYSHRAFRATLLVRSILALLGASAFQGSIKWWCLRHRLHHRFTDDPLHDPYAATRGLFWSHMGWIFFKSQYERMKTIERDDLEKDPVVQFQHQYYVPLALITGFIAPPAIGLAWGDPLGAFVYAGLVSRLLIWHCTFLVNSLAHWDGLQPYSDDNTSKSNLVLALLTCGEGNHNFQHSFPHDFRSGPSPFDWDPSKWAIILLHRLGLASGLRRARVDEIKAARDYMRQKEEYGSSSQYDPLSSSETSSTPGNTDYESDQWDGEYWTRKRAIEYATQQSRCVIVLGGYAVDVTRYLTEHPGGAALLRRYAVGKMDDDAMGKDAGQDADWAFHGGINKHSQAAMRRMRKLRVAKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MQ38</accession>
    <name>A0A4Q9MQ38_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="9">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_962672</name>
        <name evidence="11" type="ORF">BD311DRAFT_755904</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145257">
        <property type="protein sequence ID" value="TBU52303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MQ38"/>
    <dbReference type="STRING" id="114155.A0A4Q9MQ38"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="529"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU29890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU52303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="560" mass="61102" checksum="0BAF4DAD38CD71D3" modified="2019-07-31" version="1">MQRGLPMQPTVVLLKEGTDTSQGKPQLLSNISACLAIAETLASTLGPRGMDKLIVNERGEAQITNDGATILKLLDIVHPAARTLVDIARAQDAEVGDGTTSVVLLAARLLKEVRNYIEEGVSPHIIMKGFRKASELAIEHIKSVQITVDKSDPEQFRSLLLKCASTSMSSKLIHSEKPFFSNMVVEAVQCLDEEDLNENLIGVKKVPGGGMQDSLLVRGVAFKKTFTYAGAEQQPKSFRNPLILSLNVELELKAEKDNAEVRVEHVSDYQAIVDAEWEIIYRKLEAIEKTGAKVVLSKLPIGDLATQWFADRDIFCAGRVPADDLQRVVQAVGGSIQSTCSDIKREHLGTCGFFEEKQIGGERYNLFTECTKAKTCTLVLRGGAEQFIEEVERSLHDAIMVVKRAVKNGDIVAGGGAIELDIASRIRQHALSIPGKLQMVMIAFAKALEVIPRQICDNAGLDSTDIMNKLRVKHANGEKWYGVDVDGPEGIRNNLDAFVWEPSLVKVNAINSATEAACLILSVDETVRAPQSEAQNPGPRAPPGTAQRALRGRGRGMPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N0Q1</accession>
    <name>A0A4Q9N0Q1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_812664</name>
        <name evidence="11" type="ORF">BD311DRAFT_844860</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N0Q1"/>
    <dbReference type="OrthoDB" id="2721240at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597598" evidence="9">
        <location>
            <begin position="24"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="43"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="326" mass="34557" checksum="24D4DCA175C05FEE" modified="2019-07-31" version="1">MLSFFSPASCAFILLALSRYVLSAPIASSGTGADTQNQTSPSPAFVIYTNKFVSSSVLPPVNELKGYNVVALSFLLLKGPFDQAAAWAALPDAQRAATKTEYANAGIRLIVSAFGDSEEPTTSKSDPLATANSMAQFVLSSGLDGIDVDYEDLDAMNKGDGVAEAWLVTFTQTLRQHLPKGQFILSHAPIAPWFSLNSVFLKSGAYRTVNKQVGHLIDWYNIQVMTEGANEYTDCTSIVSSSGTQFPQSSILELAAGGIPASKLVIGKFATVSNTTTGFMDPKTLGECVSSAEQQGWSAGIMAFEYPDADASWIAAARGSAFPIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N1X4</accession>
    <name>A0A4Q9N1X4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Short-chain dehydrogenase/reductase 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Retinal short-chain dehydrogenase/reductase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_927261</name>
        <name evidence="15" type="ORF">BD311DRAFT_713303</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N1X4"/>
    <dbReference type="STRING" id="114155.A0A4Q9N1X4"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052650">
        <property type="term" value="F:all-trans-retinol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05339">
        <property type="entry name" value="17beta-HSDXI-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000131">
        <property type="entry name" value="Short-chain dehydrogenase/reductase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Ketoreductase" evidence="14">
        <location>
            <begin position="107"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU58411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="387" mass="43668" checksum="D13B4E0A9BC5A122" modified="2019-07-31" version="1">MEPESAQTIEAVNTVTISDFWDPLYDSFDVDLLMKVLSHTAFSPFFTFFIPLFYYFQGSRWPAPILVFSTFWVVAISSFWFLKWYSRLYRNQGNLLFGPPRLDWGDQLVVITGGSSGVGELVANTLAVRNVTVVVLDVNPIVTENYNITYYKCDVSKWEEVERVAKQIVDDLGHPTMLVNNAGVVQGKTLLDLSPEDIQQTISVNTLAHFWTLKAFLPEMIKQKSGHIVNVSSVSGMVGMARLTDYGASKAALINLHESLRYELDHVYNAPSVRTTLVIAGHIMTPLFSAVRHPANLFYKFFFPSLVPIDVAKAIIAALDEQHSRVLYMPFYAHFVPYLHVFPSYLRDLAQWITGCDYALEDFVKVSGRRPEEGPAPPVPQPRDKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N8K6</accession>
    <name>A0A4Q9N8K6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_827322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N8K6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="20619" checksum="C8524C8240D59BAF" modified="2019-07-31" version="1">MSTVLQKTLIIPDKMIPYLSDQLNLDDITCCPVIVHKDSHHLHFHTPQIRVPETHPFGPIPPPDTLYWLILLSKLEPGWTSAKDVHFLVAEYQKSCVIVLIQHIQSLAIFSLTVPYEYFVGDTSSWWAQVVWNVLSRVKILRKLDNEDYLPGELYCVPLDPITNNWKINDEVQATYSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9ND32</accession>
    <name>A0A4Q9ND32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9ND32"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF10">
        <property type="entry name" value="TOL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="732" mass="82231" checksum="4345D847829B0E7E" modified="2019-07-31" version="1">MRKIDWKMLKHTTKEALRIMKAVLPCLSGDGMDTLAPEKSTLEPLQARSPTPNPQLDAGSMALIRRLCVSCWSLDFSDICSGTTLYFLFPALPNQPGCNVCDFFRALHVDIVDRLTPILAEPPNTVPLNTTHRRAIRVEILKQVEVAPREHKGFDLAVFDASISDTWYGNAFKQPLYIRGCDSFDTHPAKTDGDGEPDTHAHGVVSTWADLALARRWVRACTQNHLDCSPLVQGSATATLHPRTRFIDVRLWRLVQLDEILLPVPLEYVALSYVWGSDAYQLRMVTANLAAFKRRLPESTSTGAERLPKTIVDAMLVTRALGYRFLWVDALCIVQDSREDLEDQLTQMGAIYALATTTIAARGSRSSDTGLPGVSVPRGRIGNSDCSWDSEVAAANGLCVGAWTFHPDEQYEEKHGALADKRCYIWRGWTFQEQILSTRSLEFSPQRMVLWCGRKMSRPDSGYSGSASEMYDPHHFRHAIRRYLSQKGAASDVGGSASGIDDRWLLARWNTIRDTYSTRSLTYALDRRRAIMGTAKVLNDVIGGIDSGGHIRTNLHTELLWYLDLKTDRAQKMLVKFSRDQAPDGLFPSWSWLNLWPVTWPALGEPLPDVTVRISSHSEVTSNTAVEIDARALELRLTETLDGGRKLVYPDGSPANITVRLDSVTETGSMITCVPLARGISIMWWEQELLLLRRVEEHYVRIGMGSLPEHDSERFSEYLYSEEGQRRVIVCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9ND74</accession>
    <name>A0A4Q9ND74_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">endo-polygalacturonase</fullName>
            <ecNumber evidence="2">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_841467</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="2"/>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9ND74"/>
    <dbReference type="STRING" id="114155.A0A4Q9ND74"/>
    <dbReference type="OMA" id="GYCHGGH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="37559" checksum="7EC9752BE8955473" modified="2019-07-31" version="1">MSSVLRLAALLALARAIVAAPTASNCTGTIASLDDVDDAVKCTTVVINSFTVPAGETFNLELADGTTVNMEGDVTFAFKEWDGPLFQVSGKDITFNGNGHTFDGNGPDYWDGQGGNGGVTKPAPMMKIKISGTYSNVKVLNSPARVYSVSNPAALTMSSLTIDDSAGDAPNSKSDGKAAGHNTDGFDVSTTDLVIENSTIHNQDDCLAINKGSNIVFQGNTCIGGHGISVGSISSSVTVSGITIQNNVIQDNDQALRIKTDASATGSTVTNITYSGNTGTGLRQFGVLIDQSYPDTLGTPGTGVKLSGVNFVGSTNSLSVNSDAQRVAVNCGVGSCTGTWDWSALKVTGGSAGPITNFNGIENFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGE3</accession>
    <name>A0A4Q9NGE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_946517</name>
        <name evidence="1" type="ORF">BD311DRAFT_776753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGE3"/>
    <dbReference type="OrthoDB" id="2741677at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU30453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="234" mass="24755" checksum="B6348C3A41E3D7C3" modified="2019-07-31" version="1">MACILKPTMPTSCSPELYGMDISLESVAVACPTMINVHEWLMIHHTIITSTGCPGGKYDVFAVAEFPIFAAKAEYISMSIGIPLGPVTVEFATTLDIRQGCSSHLDKVTANIKYPLLASVKGGAFKGNLHNSCGITMSIGVPEIYGSVRLWIDCDSLWIDFDLTVFGVPYKGKFAVLPIPRWFIAVANSDKLLDAPAGKISPLPSPGAINVNNATNNITNIVTAPASGAAVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGK7</accession>
    <name>A0A4Q9NGK7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Voltage-dependent ion-selective channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_956312</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGK7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NGK7"/>
    <dbReference type="OMA" id="FKQPAFH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU62206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="294" mass="31148" checksum="08E27354EEF09555" modified="2019-07-31" version="1">MSLPQPVPPSWKDLGKSSNDLLGKDFPINGVALDVKTATPSNVSFKVGGSRDTKSTLIGGDIEAKFFNKPHGLTFTQTWTTSNVLKTQVEIDNQIAKGVKLDLQTALTPDTGAKSALFTTTYKQPGLHTRAFLDIFKGPTFTADTVVGRDGFLVGAEASYNVTEGKITKYATAIGYSAPEYAVTLHGLGNLTTFAASYYHRVNPDVEAGAKAVYDTRATGSNVALEVGTKVYLDAAAFVKAKINNSGILALGYTQALRPGVRASFGLALDTQRLNDATSQVAAHKVGASFTFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIB6</accession>
    <name>A0A4Q9NIB6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_991766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIB6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="24"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="323" mass="35401" checksum="105AE631FC5E2E6F" modified="2019-07-31" version="1">MSSNSSSAAADIIASYAATAVTNYCSLAGIVFLMYAYTITIGREVELFWMRKFSGATLLFLANKYISLVNHLYDLAMFIGIHVNDKVRRYLLFHDISFIVTGIPLQTCNIEVEVFSSVDWLQYVPWAAFSGLRVFALCRMYSVSVVVSVLSLVPLGVNFGSKTFGVNEPGVGCGMDDDYSPSMSLNVLLIMNVFHIVFSFASDTTSNVTLFTEPSPKLANTLTAVLTSHFLLDLQEASQKEVQQDDTIEQSMPSRSVIGSKLSFAKVIGSLDSALKPGLYLGVDIDSEMVRDEYDVSVELSPVDFADPERLSYPQGSVASHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIM6</accession>
    <name>A0A4Q9NIM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_826331</name>
        <name evidence="2" type="ORF">BD311DRAFT_668362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143451">
        <property type="protein sequence ID" value="TBU26089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIM6"/>
    <dbReference type="OrthoDB" id="3185381at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="31"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU26089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="200" mass="23201" checksum="EC89B1CF7B02523C" modified="2019-07-31" version="1">MLATSSSVYHIRSPVSPVSSKTHKLVLTTTSLRNVVLANSSDVLYYEVVTPAWERHRTRVSRLDPNAQVFSVVAEMLNGHAPEDTKGKEEDAKRAMALRWFGGGEYVAVNDFLHFAWFRGKDGRKYTWYGDKKRLELRRDDRPDRPVASYHKEKRLLHVLRISQYPYLEVDRDPAVIETLDYVVVSFLLVERLRRDYGCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIP3</accession>
    <name>A0A4Q9NIP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_916039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIP3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIP3"/>
    <dbReference type="OMA" id="RQHRANK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000003">
        <property type="entry name" value="60S ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="130"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="24067" checksum="53AB74F61E073A70" modified="2019-07-31" version="1">MGFRYNNVLHANHFRKDWQSRVRTWFDQPGRKLRRRQARKAKAAKLGVRPLTLLRPAVRAQTVRYNRKVREGRGFTLAELKEAGIGKKEARGIGIVVDHRRRNLSEEGKAVNVERLKAYKARLIVFPRNAKKPKQGDSTGEDLTAPISRTSIPLPPPFVPEAPRKITEEEREFQAYRTLRNERAAARNEGKRKIREAKKAEEEANKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKK5</accession>
    <name>A0A4Q9NKK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_843191</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKK5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="37"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="279" mass="31350" checksum="1308BA1E899D13F8" modified="2019-07-31" version="1">MSAQKALSLAATVRLSSGYDMPKLGLGVFENYDCIPACLAALKCGYRHIDTARYYKNEDQVGQAIEQSGIPREDIFVTSKVYDQEHGYESTVRAVDDSLRKFSYEYFDLYLIHSPLSGKQRRLETWRALIDAKKAGKVRSIGVSNYSGRHIEEIRAAGLEIPAVNQIELHPFCQQRPITKYCEENGIVVQAYSPLVRGRLDHPVLRHLSKKYNKDTAQIAIRWSLQHGFVPLPKSSRPERVLSNSEAYDFELDEGDMAALDALDKGKAGAVTWNPVDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPC7</accession>
    <name>A0A4Q9NPC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rpr2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_393231</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPC7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NPC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="26386" checksum="EE5D2131FA8B01A1" modified="2019-07-31" version="1">MGKKKKEQEPAAKLNSVTNRDIIQRINFLYQASTYLSTISQPPDGTVQLQRNDSTHGKRKKNTIRHPKSTAELSRCYVGSMRIVGQKAIVRMDPSLKRTLCKQCDTVLLPGATASVRVKPSGSHGQVVTYTCLSCSTSRRIPAPPVLDLDASTAEPFAPSTPVDRAPSSSAPGPLAEALSDIMDVYAPSQEASVRKRGRPRNHRRRPVPRIPPLFERPGHVVFRGNEVLPSQHFNGSMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPY3</accession>
    <name>A0A4Q9NPY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_913418</name>
        <name evidence="2" type="ORF">BD311DRAFT_745394</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPY3"/>
    <dbReference type="OrthoDB" id="3262732at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10578" checksum="76AED676FDC40234" modified="2019-07-31" version="1">MTAYHDPHSIEAKKARYSQELAAYTLRQWDSVRHSIEDGDSSEGSGPPSQQQDRSRSASRDSETAARPRGIQVHDYAQTSRRHLNGQRTIAAGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQN0</accession>
    <name>A0A4Q9NQN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_824692</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU56024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQN0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF30">
        <property type="entry name" value="MID2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043590675" evidence="7">
        <location>
            <begin position="25"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="315"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="379" mass="40891" checksum="ECC7AF5DA8F5D20B" modified="2019-07-31" version="1">MVWLKAFNLGIVFLYGVWTQPAHAGNTTCASSQLDWYTDMVGESPCVTYQRLRQICNQDYQVPNFKSSVPGDLCDDEVVAYQLSMLCMNCQWDLKLGNQEGCDAQQLWCWDKQFPNSFIKIGALANGHKFNGIVDNIRSFSHSAYSRERAGLEAAQTNNNIFTHCPNQIITVSTPTSASNPMSGVPITESATTFAFTSNSVLGGPSSEPPTTITATSNSPSGDATPSAGDNVRHSNHKSHANVGAIVGGVAGAAGAVAIIGGLIVLWRRRKQRHDIRDGENPTTQRHHSYGYRAVLSTSMGEPIGASFGSPALEGFRGNADHSPPAYGSWQPAVAASNPPIPPISSTPGPNVNAPPRSRMVWSELPSRTQPLEEKWRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRP4</accession>
    <name>A0A4Q9NRP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="36"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="61096" checksum="A14EF09BCB8E95C6" modified="2019-07-31" version="1">MTSGTNLRFAMSLPRQSAARVKPSPTRRELLGGSPIHRLPVEILAEIFVVFASLESKTVQKAGWTQILLVCKFWYSIACDVASLWKVIHVNPNPDWLRLCLDRAPRCVIDLHIPQLHPRDFNAARHIIVPDRHRIRALHFRTTHDFLTSNVADFLTEGFPALEELTFLPIEWRVKRGTSLGLSADAFPCLRTLVLSGVSIPREPRFYQNLRSFELHEKCSERSGFTIDDLLDALHAASPHLQELDLSRFDPTSSPSNNQAIRQIHLQSLRSLYMENDFVVASELTKHLRVPSNVTLRLRISLPSSGPAPRDTTEQLFAAILPPNMRIAFDSAKELSIHIERNRFVVHVFDSTSSDYQINRPNERRSERVNVGFFGPYTYDDALQAVPTFGVSQRLTVLTVTSPSIPQSVAAWKVLLGAFPLLNTFTVYAGRQMAFDGAVDGAFVGLSRERQAETAASISSSRRTPRCPLLKAINIVCLPGMGERRFRSGIGPFFNIVVECLRSRAGHAGRLETLSFKSFMHSYRTGLEDSYAELGKLVDNVDIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NT01</accession>
    <name>A0A4Q9NT01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_937391</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145206">
        <property type="protein sequence ID" value="TBU53709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NT01"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU53709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="500" mass="56992" checksum="3E66E5E6B42D1191" modified="2019-07-31" version="1">MFDIPSIALASMIISSVVFITRWFTHPLKSIPTAGRFRFRGLSYLDALYNTFYAKISMEAGLDKYYGSAFKLAMLDGWMVIVSGPGMIDDLRRRPTHELSISDGLLEYMHFDRYLSHASLYDAPHLQAVKMNMTVRKIKTMIPVLVDELRHVMDDIFPKCSSGWEEVQIFTTMQCVITRMSNRIFVGIPMCRNKEYIELATEFPPKSVKRGFLLGLCPHLLKRHVARWLNPFPLAVKQTLPLFSEIIEDRRSRTMERYDTWEKKPDDVLQWLIENASEKKHSDADIVESLFLLNLAATHNTASSLTQAIYHLTERPELISLLRDEIHPIIATEGWTAESFDKMEKLDSFLAECQRYDGVGMTSMIRKAMKDITLEDGTIVPEGALVHAAAYAVHHNEASYPCATKFDALRFLRLRTQADALGTKYQLTSASPDYMPFGYGRHACPGRFFAAIQIKLVLAFMILGFDLCFGGDGTRPENVDLGFNILSDPRGLMLFRQRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTZ6</accession>
    <name>A0A4Q9NTZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTZ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NTZ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="41"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="37764" checksum="7F2088095BFE955A" modified="2019-07-31" version="1">MKIEAFVFDPSEPNSPQLKLAFKRYSRDDSTGCNPSGALSLLLAHGSALHKEQWEPTIEALFAIQDSCSRRALVHEAWAVDWQSHGESAVINDNALQDRPEGISISEWGFALSQFMSSAHTRNRRIVAIGHSAGCSAIMYSTKYLLNGPNSYAAIILVEPPMIDRDVFNDHLQERLQQVGAITKSVAASRASWSTKEEALKWLSAKYPWKTWDPRVLRLFVEHGLREHRDDGGRDCVVVKCSKKHEASAYKDFESTFEATDMISAVCRAVPLHIIFGAKNDLVPRYSQDSLVDASKGRVPQSITRLPGAGHLVVQEKPELLAEALAEILDTLVVSDLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NU50</accession>
    <name>A0A4Q9NU50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Saccharopine dehydrogenase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1026746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NU50"/>
    <dbReference type="OMA" id="GPYQLYG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="442" mass="47794" checksum="73397D374E1EF4E5" modified="2019-07-31" version="1">MVVDILVLGATGFTGRLITRYLASHPQRNSFTFAIGVRSKTKGVELLKSLGIENDGTVRLVEVDVTRYETVEAAVRDTKVVINTVGPFWLWGTSVVRACALLGRRYVDLTGEPQFVRKIIELFDHIATKTGAVIVPSCGFDSLPSDLAVFLSNRTLKNAIGPQTQLGLSQTFFDIKSGISGGSLATLATEIEEVPQILLAQSRQDYALSPVHGYPSPAFQKAVRVPFSSPPAYGAFWIMANVNRAIVQRTFGLNELLANYSGALLTSAPVQETAAQIRPLTYGPEFRYAEYMAVGTSRLAASVSSTLLGVWLALLFYVPPIWWFVKLFLPKSGEGPSEHQLKTGYMTVTNFTEAASAPGTWAKTTIHGKGDPGYLLTAGMISECALALALDDASLPPHARLGGVLTPATALGSDIVSRLEASSLLHFESQIVRGQEESRKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXQ4</accession>
    <name>A0A4Q9NXQ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60Kd inner membrane protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_807532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXQ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXQ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="YidC/Oxa/ALB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Membrane insertase YidC/Oxa/ALB C-terminal" evidence="7">
        <location>
            <begin position="59"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="316" mass="35076" checksum="B08D157C1F58B0B9" modified="2019-07-31" version="1">MLSTRTALATLRPALRPARCGPRHLPPRRTFIASTIQSLSGGFLDLAIALPYPPGWPPYSCTIILVTVVTRLAFTVPFSVWAKNRQWRAETIVIPQLKSEMSAIHKQVQRDMKRDGFRGDKDAVIAEINKRTRPIATTRRKELLAQHNASPMPTIIVPVVTQLPLFIGTSMVLSHASTAPTVLDSESFFTLTSLAHADPTATLPILLGVITLANVESSRWFVGAEVLQREAQVAKWTAERRARGEQILEPRKIHQSALRVLSVGRILIAAMVPGSVQLYWVTSATFGLIQSWILDYWDMRRRKDVGPPPTTGPKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYF9</accession>
    <name>A0A4Q9NYF9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_967625</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYF9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF5">
        <property type="entry name" value="RE44586P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="575"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="623"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="648"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="711"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="861"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="952"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="871"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="895"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="920"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="970"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1018" mass="114950" checksum="46D22336E279D45E" modified="2019-07-31" version="1">MSPYLELSLRVLARAFIDPSDPGGDPGPPPGSPPRIRYDGPWFATQLTISGVIGLLSFLVFSYCRTRWPLLFAPRTKLKGFSPHEAHAKQAFFGWILPTIRISEFTVLQIVGLDAAVLLSFFKMSFWLFSSCSVLAAVILMPINLKNNIDIGDGREDAPYPGNYTEPPTTDPTAPPTSWDNWFDLISDASSYLSVHLLFTYVFTILALRAIYKNFKRFIRSRQLFSLELVHSVPARTVMVTHLPPHLQTEPALAEYFEQMDLAVESVNICREVGSLKNLLDIRTKALLKLEAAWVDYLGNPSQVAPSRSIRSNLIDVDDAASIESQPEQLVLPNRKRPTIRTGWLTRKVDAIEYYEEKFREADELVKKRRRTGRFKPTHVAFVTFEKMSSAQIAAQAIHASQPTQSLTHLAPEPRDIVWTAISHSPLNALVREWLVMGAMVVLQFFWFIPITALASLLSPEEIRKIIPWLGEMMDRNERIGALVQTLSSMGMVMLNATLPFLLEGLTYIQPLPARSWIEYSVMKKYFLFLLVNVVFIFLVASTYWQLVRDLAQSPAKGLEKLAQALNAGNARHFFVSYVILQGFGLMPLQLLNLGIIIPRLFFRLFITRTPRDFAELNAPPMINYGIVYPQAILVFVITLLYSVIQPLILVFGAVYFGVAYVVYKYKLLFVFYKPYESQGQAWPITFHRLIWGVLIFIIFMSGMFIVKKSFILATLLAPLLAGTLLWWYYTDKQFRPLSKFVSLSSVHEVERGEESADVVRLRAGHPVTWSQSNLNRRRYAQNDETLYVAPEDERTDYSQPPMANFYSGVLNTGKRRYGHPALTGVLPVPWLPIKKGQSLNRHRDTGDDEGPGVVLTLRKKYSVLRPRPPSQHSDGSGASTQSAPETTPAAPPAEGDRPEPSDRSVLDRNPWEEQPAGQRRARPHRRTNSAHPVQRRLSFDAASGVIVLPEDQDWLSGGDSDSDDYGELQASTLMDSQILQGEPSEGGSVVAGTLPAANKRYSTYYHHPERRKTYTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P037</accession>
    <name>A0A4Q9P037_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_922784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PET117 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P037"/>
    <dbReference type="STRING" id="114155.A0A4Q9P037"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031568">
        <property type="entry name" value="Pet117"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28163:SF1">
        <property type="entry name" value="PROTEIN PET117 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15786">
        <property type="entry name" value="PET117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043512332" evidence="6">
        <location>
            <begin position="23"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9777" checksum="D6521AD7522318C7" modified="2019-07-31" version="1">MSRAAKFTLGTAIFTSVLVVWGVHHLQVTERATMYQGVLKDDERRREKMRQREEELQRSLQKRELYERMQTVSKPAPDLAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3B6</accession>
    <name>A0A4Q9P3B6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_852080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3B6"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3B6"/>
    <dbReference type="OMA" id="GEDWWMS"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="165"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="398" mass="44640" checksum="619646673E30106A" modified="2019-07-31" version="1">MLIYDILPFCVQTQRLIKNTSALRFGILGAARIGPEALFKPAKTHPDVVVTAVACRDKTRGQQYAQKHDIPRTFSGPNAYHGKSLHIYAQKLVTDPDIDVVYIALPNGLHFEWTMRALEAGKHVLVEKPLTNTAEEARQIFALAEEKGLVALEALHTVFHPANHRVREIIQSGELGKVKSVVSHFIFPRFISPLFFEKDDVRFHYDLGGGSMTDLGVYPLAEIRFVTSSDTVPLEVISAKAVGHPKDPERIDRAMHIVYALPNTDATAEVNIDFSAPGWGPFGLLPRMMRIDATIKLEGGSIFIYNFVMPAAFHFIRVTPKKGSGRFEQVYTFKGGKGERSWSTYRYQLEAFVDKVRGRTPSFWHEPISSISELETVERVYTKAGMQPRPASAYKRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6Y5</accession>
    <name>A0A4Q9P6Y5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_7030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6Y5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="101" mass="10690" checksum="0A23296821A1408C" modified="2019-07-31" version="1">MPTLRPAHPPRCPYSPKHAQSPRSTDVRAGRTASSRAGALLQCFSAGLECAPTQLAVYPPKLSTSLSSLEATMIVPAPHTRRRSFVLARSGCSSPPCSCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8Q2</accession>
    <name>A0A4Q9P8Q2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Oxoglutarate and iron-dependent oxygenase degradation C-term-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_868109</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TPA1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8Q2"/>
    <dbReference type="STRING" id="114155.A0A4Q9P8Q2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.20:FF:000003">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.3, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0847">Vitamin C</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="275"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="547"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="648" mass="71717" checksum="D94CF9A21A770298" modified="2019-07-31" version="1">MTSKTHPRSPSPPPSAAQPSLLKRLKSSHISEDPPSATPDPTPHFAADLFVPSNIHRLHTEYENSGPFKHAVVEKLFQDDLLKQVKDEALAELSFSEKETDIYKVYQTGDLASLSYLSEQQLALLPNLLTLRDALYSPMFRNFLRAVTGCGPLSGTKQDMSVVSYRKGCHLLNHDDVIGTRRVSYILYMPLPHYQGWQADWGGALELYPVKPGPDGVPEPEPVPEKSVPPVWNQFIFFEIQPGRSFHSVEEVVVGESEDGRQRLSISGWFHAAQPGEEGYAPEPEPELKSSREQLTSTQTDFKPYPENVDPPLPDEPLSEEHVSFLSEFLNPVYLQARTMKALASRFVEESSLELHSFLCAPLADKLRTGLVEKDDQDGLGPSRATRIPPHTAGSGGAWRIRGPPHKWRYGALRPLEGTGPKMAVSPRWAHADVDDVIRGLQDELYPSTAFRAWLACVSKLLPVRHAEEARRFRPGLDYTLATSEPSEARLDVVLGLTPQVETQGAEGAQNGHTNGHVSTEEVAPVGWQTGEWGGWECYMAPHDEEDDPAVYRSGSSKKKNEANGTNGHSASKEEGAMQGVEEDEEDDDDDGTLLTVQPGFNRLLLVLRDEGVMHFVKYVSAAAEGSRWDICGEFEIGMIQVESGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAA4</accession>
    <name>A0A4Q9PAA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_833987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145304">
        <property type="protein sequence ID" value="TBU51584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="323" mass="34913" checksum="76719FBB5F4E6F04" modified="2019-07-31" version="1">MYLEALGLESVNQLPEGSGTPPPDDPQIFSGHVDVFLQSLISHVCQEYNSPLFSIIRHLPAPPVDTDAAVPTTRPTPLTMHVHSTLCPGGDLLLTSAHLSGIHAVFPDVRLYLEHETHLRELVSGGKSFDFAEHPIPAGIDTFVAIWNKDAHSLYGFSSVDPNSGAIILTTRPPPPAELLYPTLLREEKLEDRFKLSREERQLLERLKADAAMRESGRVEKSRRQYEGREARRKSKARLGAHSSAMRKVASALATTLDLQNQAGLDLGYEAGSPSNAGSPGAGIGLSQLLNVPDFASETAHADGEDATMEFNPVATEGDANAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBK6</accession>
    <name>A0A4Q9PBK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_813407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="216" mass="23884" checksum="0C90CA13D946B5F5" modified="2019-07-31" version="1">MRSDSLTRYLRAGDFSSAFYDLRDCIAGILRHIEAIRLGRAITVDHGDAVCTFRLPEDKDSKLHLYLMGLLRKIQTKEFTKRQTEVRGAIGTLFRENLGDREAEPIDIVLLGTSPEKQGHGYGKALVKAVTDIGDAKGLAVTVVTTDAYKFYEAVGFKLVAETIVGVDNPSWDGAPIHVRLLLREPHRHGSGEEQIPKAASDESSVITHRTGRTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBU6</accession>
    <name>A0A4Q9PBU6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_834279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145318">
        <property type="protein sequence ID" value="TBU51475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBU6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8043" checksum="A62A80896BD458D7" modified="2019-07-31" version="1" fragment="single">LTASTKYQSAPPALQIAPHQLPSPRPSQPPPHPPHHHRLPHAYLQSVHSHFLARVMTPVVVPISKQVVHRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD44</accession>
    <name>A0A4Q9PD44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_831600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145239">
        <property type="protein sequence ID" value="TBU52719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020847520" evidence="5">
        <location>
            <begin position="17"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="98"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="294" mass="31112" checksum="DF13CF1A0AF89177" modified="2019-07-31" version="1">MISVALLAAFARTTTAAVIKRQAAITALTPTQVTSFRPYTHYASTGYCTPASTIAWNCGENCEANPTFKPIASGGDGDETQFWFVGFDPTLGEIIVGHQGTNTSEILPLLEDASIIRESLDPSLFPGISSSVGVHSGFAGSQARSAPDVLAAVKAGLTEFGTNKVTVTGHSLGAAIALLDSIFLPLNIPGITTRFVGYGLPRVGNQDFANYVDSQPIEVTHVNNKEDFIPILPGQFLGYHHPSGEVHIQDSNAWLACPGQDNSDDRCIVGDVPNIFVGDESDHDGPYDGIEMGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE14</accession>
    <name>A0A4Q9PE14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1008533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145363">
        <property type="protein sequence ID" value="TBU51201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE14"/>
    <dbReference type="STRING" id="114155.A0A4Q9PE14"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="23153" checksum="40B091776FE4356D" modified="2019-07-31" version="1">MRRMPTFGRDRIRRFSHDVASRKRLAARDYEAFLITMMPALEGLLDLPDDQTVADLLFELANWHALAKLRLHTTITINIFRAATKHMYDVIRTFANKTCPRYQTKELSSEATARVRRAKATNVHTLTSSTRRPIAFTVHHTYKFHSLGDYPNYIERSGSADNYNTQVVSTITVVSLASNCMGLHRQRCICGHATANVHLDECS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEX7</accession>
    <name>A0A4Q9PEX7_9APHY</name>
    <protein>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU51632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Small ubiquitin-related modifier I"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
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    </dbReference>
    <dbReference type="Pfam" id="PF11976">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10861" checksum="4EC07349F99B6F79" modified="2019-07-31" version="1">MADHEPGASQDAEPKQEDANAPINIKVTTQTGEEVFFKIKRNTKLSKLQGAYANKVGKDVSSIRFLYDGARISDEDTPASLDMEDNDTIDVMVEQVGGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFA2</accession>
    <name>A0A4Q9PFA2_9APHY</name>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="TBU53654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFJ1</accession>
    <name>A0A4Q9PFJ1_9APHY</name>
    <protein>
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        <name evidence="2" type="ORF">BD310DRAFT_962967</name>
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        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <end position="23"/>
        </location>
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        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
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        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8706" checksum="F16639A4EEF15BA7" modified="2019-07-31" version="1">MRRTQFGDFHREDTREHNRVTTSSTSCFHKYLVSDSKSLSHKEVRTSGPGTTLRASSGRFPSGRAQPSFPLQRHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFR3</accession>
    <name>A0A4Q9PFR3_9APHY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
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                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="TBU53860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="333" mass="37404" checksum="8E4310B61233CED6" modified="2019-07-31" version="1">MVMKFLRTWSQYFTEHLAPVVETIPEYDLPLHIDMPSNRERVAYMRSKLTPILFHTFPLENIPYSIFSPFPVNRVDVYLTGQQVLVLYQRLSLLFRDFLASRALSSEDFKEVVKLSRQDVLSAFIVTAISVSRGEPITQVTNVVNCRGFNPAIVPEDAAGNALLYALTDIVQSPGLDRESLGGTIISYAHAIRLSLQAAREPQYVHDFLALAGQEWLAAARANRGHYIAETPGHVVINSYYRIDWASVHFGSPGKVCWQHPDHIMTDNYIMMFPSNPIRGNHGVWRTDDGACEMTFNVKKGMEETLEVALALLWDVVVGSPSGPAFKTSQVAF</sequence>
</entry>
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    <accession>A0A4Q9PGJ9</accession>
    <name>A0A4Q9PGJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6259" checksum="7C4C47708D4BC4A6" modified="2019-07-31" version="1">MPRSNEADRAVQAASVASLLTCGTSFGTPCSSSTVSPPQLLPYPPPYVFQHRLGYCETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGT4</accession>
    <name>A0A4Q9PGT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">BD310DRAFT_941587</name>
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    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145285">
        <property type="protein sequence ID" value="TBU51796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGT4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6260" checksum="CDCBC80145688C83" modified="2019-07-31" version="1">MGRSIPGGGARQPCFGFELPANIVSFVVVHALVWRCTEFQRLTRTEVGLTAITRSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ71</accession>
    <name>A0A4Q9PJ71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_828649</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ71"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="167"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="754" mass="85383" checksum="709C917DCADB3836" modified="2019-07-31" version="1">MADNLSEIELEKMFEEFIPGEDPCGDYLTHCDYDSHVAKVKKESDLNPKICVMAHSAIARARVCPTLVVRDISCWQVSGQDRKSSQKGTRSDCAVYLDNERTRKIVDMDRDDFMKSSRMSEEDKNARKDWVGRRAWGDMVAFVEVKHNHDGSAFEFNNPGTRFTRDDTDGGRKALGQFAEYVANILAHQHRTHVYALYVYRDRARICFFDRSGGVVSTPFHYGTTADTTFQRFFYRLAGMSREQLGFDPTAVLADESAVSALRAWAAAVPTEYLRKLACKALCWDPATNSPSSVEWPTHEVTFKGKTLYVGKPTFSNLALFGRCTRGYVAIEKETGEDGSVAYSLRYLKDSWRNIQPHVHPEHEVYERLRSRGVVEYIPTCLGGEDVAGAWQRTSAGALLQSNPLPRGHYRILLKEVCRPLSDFEDYQDLAMVIGDALSAHRDAWEKAGVLHRDVSYNNILIYVTKNDEGKDIHVGLLVDWDLSKYKEYMVPGFGPRQPDRTGTWYFRSAVSQRYPRKPYAVSDDIESFVHVYHYCVLRFHKTEQTKTLTHTVCSTYEYVERRAEDGAYVGGFIKFRQMCSPTPAIAPDNNKTLLALLQDLADICAAHYATIDAQEFDRLYTPVPETPATTAPQQEAATAAQPPRITLARAHAQKKSVESRQRRPLQVTPSPMLQDHSELLNVLREWGTEIDWPANDLVRSPEDLFKQVGLAPSKDNAFGSSHNESSRPAKRLKLDTGTPLTSVHENVERLDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKW0</accession>
    <name>A0A4Q9PKW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_935126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKW0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6826" checksum="B5FBD72D12B667B8" modified="2019-07-31" version="1" fragment="single">MFRSIQRLTTILGQITTVLRSSYALSGSRSSMDEDIYRWLLYGTILGLHLSTLLPAPVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL22</accession>
    <name>A0A4Q9PL22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_934912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd21075">
        <property type="entry name" value="DBD_XPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="416" mass="46416" checksum="4D9BB61F2B009368" modified="2019-07-31" version="1">MSPRKRKGKDREEGKRKRRRVDSEEDCLEDGRGDAGSSASGLDTYGWETAIPEDWTISKAMAMLDYRLTHADFQSITAREKKRTEEGRHAYYIYNERAVEWKAWEKHGGPIGLWKFLKALKKEHEASGSTDPFDIPYSYAADRLYDLDLPETPELSDRYVGDLRLLRYAKQSLPPWLWNVCNSKLNKALLDGKRPNGCDDLTEERQRAIGALVSFVNENPIRYIEKPAQDVAPSLYIATLRSVLAAAPIAPRFGSQAWGTPVAGLDFCEADGHPRYEWCASYLQRIFKALCTVISKHGIGNEGWRSIRWEVYETYVETVRGGLTFYRAQMEWTDYAGVWLDAQLSPKDIKESLRGKCEAGIPYNQLLPSPAALEASSSLPPPSAAGPSSPAPCPASSQKQTAGPSSSACMPSPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMJ3</accession>
    <name>A0A4Q9PMJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_685529</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMJ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="308" mass="34760" checksum="61EBC40781A3F119" modified="2019-07-31" version="1">MIAPSLASSSHGVVPLLQTSPVRALTTLILNDIAWRTALRNTEGRDEPTQTPPHTPTHARNVASLLASTSMAYLVSPTPIPPDAALPRYHPCPISPTKQRYHDILKRESNTTFEAELQQTLQVAQAREDTHKHEIAGMQAAVVLQGTFVGRVQERMQKQDERKGMKKSQQLMGDGLPKLLSADVFYNTVVDQESTQDQKEADKAERKTERQRYGKEMGQWKQLAEERNTRVAAQSERYKQAVAGWERERASARTEQRKIGWEKPKKGRVEPVPSKPKLKRPTETTASDEEEDNDNDGEENHDQPDLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMU5</accession>
    <name>A0A4Q9PMU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_933407</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMU5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMU5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="20"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU55583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="343" mass="36843" checksum="7525287855D72477" modified="2019-07-31" version="1">MTSSNHPESYTAYAFTEKGGELSRITVPWKDPKDGQVVVKVIACGVCGSDEQVPKAIYPIQYPRIPGHEIIGDVVAIPPNETKWKVGDRIGGGWHGGHCHECARCRVGDYITCENAAINGISMDGGYAEYATLRTEAAVRVPKDMDPYEAAPLLCAGITVFNSLRHMNVTPPEVVAVQGIGGLGHIALQIARRMGFRTVALSSSGSKKALAHELGAHEYIDSSKADQAEELQKLGGAKVIMCTAPNAKVIEGLLPGLAVDGTLLLLALEDAPITISPLSMLGKRLSIRGWVCGHAVDSEDMLQFARDHDVGVMVSKFPLDKAQEAYEHRASARFRVVIVPDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMX8</accession>
    <name>A0A4Q9PMX8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_680683</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMX8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMX8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020821192" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="19"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="228"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="596"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="597"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="615"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU55600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="638" mass="68740" checksum="365EB4D9DC23178E" modified="2019-07-31" version="1">MLLTSRLLVAITFTLAAAAAGPQLSPRVLHESRSFVPNGWTPVRRAGGHQRIPLKIGLVQPNLASIEEYLMDVSHPDSPNYGNHWTPAKVAETFRPTPESVDTVRAWLHKSGIEPHRVKLTGGWLTANVTIAEAEELLGTEYYVYEHETGVSHIGCDKKYHLPEHVSKHVDLITPTIHFDAKIKREAPGTLEKRKVHNIGAPGFGPVNPKTTGTIKSLEDELENCDTHITPNCLRALYDFVHVPLATNKNSIGIVEYTPQAYVPSDLDLFFKNFSSSQIGQRPVLNSIDGGTIDVDGSGFDYNGESNLDLQYAMALVGKQQKVSLYQVGDTVEGASFNNLLNALDGSYCTFEGGDDPSQDGIYPDPEGGYQGKEACGTVTPAKVISTSYSYDEYELTPAYMERQCAEYAKLGLLGTTVLYSSGDYGVAGYNNTCLLPDGTVSHEGKTFTPSFPGTCPYVTSVGATQVNPGAKVTDPESACAQVIYSGGGFSNVFPRPAYQKAAVKNFLTKYPPPYSSDIYNTTGSRAYPDLSANGANYVVAVQGDFYLVYGTSASSPVMAAILSAINDARLAVGKKSIGFINPTIYSPTFQHAFNDITDGTNPGCGTVGFSAQPGWDPVTGVGTPNFPKLLALWLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNP2</accession>
    <name>A0A4Q9PNP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_932867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNP2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNP2"/>
    <dbReference type="OMA" id="HEYGSTL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052471">
        <property type="entry name" value="PBI_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28288:SF2">
        <property type="entry name" value="PROTEASE B INHIBITOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8308" checksum="1092D16FC7E983B2" modified="2019-07-31" version="1">MSGRYIVVFKDSVSQDDVKKYADEVNANGGEVGNHFDTLLKGFSATIPESYLQQLQSYQGSVIDYIEPDSTVTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP88</accession>
    <name>A0A4Q9PP88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_777931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP88"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="14077" checksum="A48722B45ACF68AA" modified="2019-07-31" version="1" fragment="single">MAEIARKHHDQVQEDDESMKPQDERELNIRRVLDSLEKKVSDDDADMIGAQVQFGECVTALREAENGTAPGLDGIQHEVWRTLFERYKEDEKAERPSFNVIRLLRAAFEDIQQNGVCGGTGFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPW9</accession>
    <name>A0A4Q9PPW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPW9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6806" checksum="C8CFDE813E06D842" modified="2019-07-31" version="1">MSGAVEGAMGRTRTWSERGLSGGDQSSRAGEEGLRGCAPCEGGAARAGWRLRKMPGKGRRKREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQE0</accession>
    <name>A0A4Q9PQE0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_608266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQE0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQE0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF55">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="343" mass="38000" checksum="00AFE10DDD8239C9" modified="2019-07-31" version="1">MIRVEAQCTKASSRLLTASHSHDHATHASLSATMLQAASHPKPLFPQTLHNFQPLPCPRIPRPSSVLSRRICFYIHEWLLKPLSTAYCRFRGIRTHPSIYPLPFGLLLKNGPRVREQEGIAMNLARAMGVPAPRFISFAEPPSGHVFSGSMLSPMPSLLMTRLPGIELDAFSNEHIDFDLVKDDLVRILTLMRSFSSPWGASICGVDGGPVAGPLIPLSQLPASTDEVAFYQQIRYIGNFAAKDKKDVAPAEQLFAHPTHAVVFTHGDLNPHNIMVGSDGHVCGIFDWESAGWLPDYWEVSVTAILPRVWGQFMNERVTSGVYAEEVQGHRSMFPHISDSLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQV2</accession>
    <name>A0A4Q9PQV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_596629</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQV2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="275"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="453"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="906"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="970" mass="108280" checksum="17FDE2C4F76BBEC7" modified="2019-07-31" version="1">MGTCWHLLSNELFSARIPGAPPTEAERSEFTSPRLRKGMLEKEIYPKLGKVIESVLDAAGCEDLRFLATTNRKTNDGNSGRKETFNDAGIYLDTPIARNATTFTAEHRKGSKMSEKELETRLLGLRSWYWMDVPIEVKGTESESAFYFRPKARGMRPEGGKEAEEVLEKTEEEADEEVKAGDGNRDGVEDVGDGIDADEDEDEEDIEDHSEVEDDEDDSEVDGREEDGSDDEDDDGGSQARDADSSMTQAESTDTPQPETVKKHVPPFIKLSGNGGKALGQFIEYMLSVFKYQHRTFCYAVYVCFDMARLLFFDRSGVHVSEPFSWVETTSLLHEFVWKLAKLANAKCFEDMGRDTTANVVDEETRRRFLDEATNAELPSHVREGLEKAAEGNCPLYELEIEYMPPSPEEWFPDEPLPDEPHPSPSAPPAPSSSTSSASPSSSRSRADPPVRKFIVGRPHFSADALVGRCTKGFMAFDVTDENNWVPCFVKDSWRPYVPGRTRPEHLVYERLQRKGMKPEDGIATLICGGDVGGSNAQCTQVQKDLPSKNRPAPRRHYRIAIAEICLPVSEFETFGELSGIIGDALKAHREAWDRAGVLHRDISVGNIMIRVEENGERYGILIDWDLSRLQCELALGAVVPDRTGTWQFRSAMSLKYPWKPYRRSDDIESFIHCYIYLVFCYHPTDAALRETIESLFEGCLIVGGVMIGGNAKRAMLRSGHFDAVVEGNPRLQQLLDNILWHCKTCYERIDFRQMNRLYGPVEDAAQTRSEVSPHPPTKVARAPIKRQFANASGRMQLPTNHLAAHVDVGSSRELESFEMGPFLSNPDYLIELLYAHAQATINIADKAPDQFTTRQHQEVYRAPDPPALRGIDKMSTGGTALSDCTSQDNPIALSHDKVPTTRRLETVGIPSSSSSSKKRAHVEDLTDNLADDEGDDDEEDGSSVVCRSKRIKAAKGKAPKAQSGMAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRC7</accession>
    <name>A0A4Q9PRC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="98" mass="10542" checksum="916B9CD24AC8D32A" modified="2019-07-31" version="1">MLVLGRVDRGLIARDGLDTMLALKSLPPRLMICQAPGRPPTRRTCRSCGCGAGTHRASESDHASLLACQFLTTAFVPSQLSRCLGIGSCRRIMGMLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS90</accession>
    <name>A0A4Q9PS90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_821976</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS90"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020444512" description="laccase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="33"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="164"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="374"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU57287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="527" mass="57838" checksum="4B74FA948DA287F8" modified="2019-07-31" version="1">MANSPFLLSFITILFAVFAIAGIGPNADLIISNANIAPDNFPRPAIVMNGVFPGPLITGNKGDRFQINVINRLTNHTMNKTTSVHWHGITQKGTNWADGAAFVNQCPIASGNSFLYDFQVRGQAGTFWYHSHLSTQYCDGLRGPLVIYDPEDPHASLYDVDDDSTVITLADWYHLAAKVGFIFPNAVPGTGFDATLINGRGRSRETPTAELAVISVTWGKRYRLRLVSISCDPNFVFSIDNHDLTVIETDGIETQPVTINAIQIFSSQRYSVVLTANQTIGNYWIRAHPNDGKLVGYTEGYNSAILRYDGAPPVEPKTSQQATQNLLNEVDLHPLVPRKTPGTPTKDGVDKAISMHFSFNKSSYNYYINNVSFVPPTTPVLLQILSGAQFAQDLMPRNSIYALPMHSSIEISFPTSASAVGFPHPIHLHGLSFAVVRSAGSTAYNYDNPVWRDTVSTGNSTTDNVTIRFRTDNPGPWFLHCHIDSHLDTGFAVVMAEDIPDVKSADPAPHAWSDLCPVYDALSSDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT78</accession>
    <name>A0A4Q9PT78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_536913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT78"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25568" checksum="1C2648281D4C241C" modified="2019-07-31" version="1">MFPHPDAFNAGPYNQHHLQRDRSRGQGNGVAGTTTNVRGMEDVASIATPSFYEANIGFVHDLPPPIAEFSSNSPPRYDLLEQTPYTAGTTPGVQLSPPLQFGGFNLAKALREDLSDLPGHSRPAFPDFISLRQKMSVRIQITHHMNWGHHMNWGHQATILRANNARPTMGQLAIVIAREVNRFLEHERMIGNPLKYLSDRELSLADIVLIEIHHVTRGSLQPILGVLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT83</accession>
    <name>A0A4Q9PT83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_880532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT83"/>
    <dbReference type="STRING" id="114155.A0A4Q9PT83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="287" mass="31919" checksum="D361BF485A1BE49F" modified="2019-07-31" version="1">MVLTWLPYLGDLEPYCTPLIPTFPPFNMADSNAVLLAQINKGGTIGVGYLGVVASSMVYGVTCIQTLQYYRSERAKTDGFWLHGIVRVESLILDSIQSAFAIHVFYFYLIDNYANPLGLLINIWWAVNLDSLFFTFRVWRLSRNAFVSGFCIFPPACAYICANLFGKYMVGTCICRLLFSNLYEAESKLEHLGAAGLSLEAAADLIVSAALIYYLYKGRTGMPRLNSREYMRQGTSSGKVLSASMTDPRMIPLSTLRVPTERCADRGATSNVIEVSRNGIRPQTCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTN8</accession>
    <name>A0A4Q9PTN8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTN8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020496341" description="Secreted protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9681" checksum="2F461D57D0E5C004" modified="2019-07-31" version="1">MHLILYSALGFYWTLSPSFPWPVVRTNEDGWGAVCQNRPLRLNVCVIEWTRRRSRSAVLDQIMYKENMRTDVACSGRIQWPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVG7</accession>
    <name>A0A4Q9PVG7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_926979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVG7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="193" mass="21861" checksum="1E0E6320B4D7FC70" modified="2019-07-31" version="1">MENDVAGLRWGMARRRQTPPGDDFARTAGRGGFLSLVGRLRSGLRSVLSARQGDHLISLSKWLQRRERHCIVGPAPSSHPRATEHRRYLHCTQLYQYQYTYSNIAEPFECHITPRLEIMSTQLFCQAPLCCVAIPYVVDSDGSRAIETCLVAVPCKCRNLRAGLLFPRDGVRVDDLLSQRLSKRRRSIIHAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXT3</accession>
    <name>A0A4Q9PXT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_877118</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXT3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="32723" checksum="6E358D4482611F3D" modified="2019-07-31" version="1">MNMFKRFFLVGLTALAAAVSAAPAPSAATDIQILQFALTLEHIENTFYNTALAKFTAKDFENAGYPDWVRSRFVQIAGHEATHVKYLTETLGSNAVPFCEYDFGTSLDDPTAFAKMSRVFETVGTSAYLGGASLLQNKAYLTAAASILGVEISQAGWVSSSVLKVQPWSGPFNIPLAASAAFSLAQPFIKSCPPGYPQLPVKELPSLTLSNTQPALGDTINLSFPNADFNNGTQYYAAWLDGLTVQYTDINANGGSTKVPNNLQGIVYVAIVSSKETPSDDNLVSGLALIAYDFDSKTNNTVSGSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY89</accession>
    <name>A0A4Q9PY89_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_795713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY89"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12931" checksum="8A74303A2D121EA7" modified="2019-07-31" version="1" fragment="single">AREAPGFPEDGVGQEWTTRFVERHSEKLKPYWSHSLDSSRARAVNPHTHKAYFDLLEKTIKGEEGEEEISPDCIYGMDETGIQEGVSLKERVLRPAGQKVQYQQRSGERENIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZY8</accession>
    <name>A0A4Q9PZY8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_332117</name>
        <name evidence="2" type="ORF">BD311DRAFT_764211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143458">
        <property type="protein sequence ID" value="TBU25594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZY8"/>
    <dbReference type="OMA" id="PVEREYT"/>
    <dbReference type="OrthoDB" id="3261081at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19050" checksum="80EF74E622ED25B4" modified="2019-07-31" version="1">MSTSPPPSPLFSRSSSGSSSGHGYIPLGVPKVAKLLVKMRRHRSKAKAHHIESSSGPAPLTHPALRGDGAVSPQRVPLEENVTFVCRDGVDVAKLLRAARASLYQKAVEVGANVLVDEQWSCTICGPRHRSDGTFRVYVRYSACGARSDKRDPQRPVALENVRDVPGLMTIVSRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q036</accession>
    <name>A0A4Q9Q036_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_815025</name>
        <name evidence="1" type="ORF">BD311DRAFT_659012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q036"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU30471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8626" checksum="D831F8497DFF2A5A" modified="2019-07-31" version="1">MRSDVRKNSCRVCRICPGRHFAEASLMIYCASVLHVFDIQPPLDIRGAPVKMKYRASDDMISCVPPRLTLYAILTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0K4</accession>
    <name>A0A4Q9Q0K4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_922678</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0K4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0K4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000299">
        <property type="entry name" value="Zinc finger protein 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051879">
        <property type="entry name" value="C2H2-ZF_Maturation_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46095:SF1">
        <property type="entry name" value="ZINC FINGER PROTEIN 593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="99"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU60539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="129" mass="15103" checksum="C44064C9A1A5DADE" modified="2019-07-31" version="1">MGRLRRSRTHHAQRDVHRASRTRARTRDLDQIQLIDLDPKTRAKLEAQPLDYERPGLAQHYCVECAKYFETDYALRSHWKSKVHKRRCKALKEPAYTIEESERAAGLGREGKRPTTTTSDTPMEQEMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1R2</accession>
    <name>A0A4Q9Q1R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Acetyl CoA carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_847436</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q1R2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.460.10:FF:000001">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000005">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000010">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049074">
        <property type="entry name" value="ACCA_BT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21385">
        <property type="entry name" value="ACCA_BT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU60514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2231" mass="248284" checksum="DDDE863DDDDD70F5" modified="2019-07-31" version="1">MSKYDHSRVAQFIGGNTLEKAPSGPVKDFVKQHGGHTVITKVLIANNGIAAVKEIRSIRQWSYETFGTERAVEFTVMATPEDMKVNAEYIRMADRYVEVPGGTNNNNYANVDLIVDVAERAGVHAVWAGWGHASENPRLPETLAANKIVFIGPPGSAMRSLGDKISSTIVAQSANVPTMPWSGTGITETTLSEAGFVTVPDDVYRAACVTTVEEGLAKAEEIGFPVMIKASEGGGGKGIRKVESADAFKNAFHAVAGEIPGSPIFIMKLAGQARHLEVQLLADQYGNAISLFGRDCSVQRRHQKIIEEAPVTIAEPKTFEKMERAAVRLAKLVGYVSAGTVEYLYSHAEDVFHFLELNPRLQVEHPTTEMVSGVNLPAAQLQVAMGIPLHRIRHIRQLYGVEHSGTSEIDFDMVDPEASTLQRKPRPKGHVIAVRITAENPDAGFKPSSGVLQELNFRSSTNVWGYFSVASAGGLHEFADSQFGHVFAYGEDRAESRKNMVVALKELSIRGDFRTTVEYLIKLLELQAFQENTITTGWLDSLISDKLTAERPDSTLAVICGAVTKAFLAAEASWGEYKRILDKGQVPSRDVLKTVFGIDFIYDNVRYSFTATRSSPTLWTLYLNGGRTLVGARGLADGGLLVLLDGKSHSVYWREEVGALRLMIDSKTCLIEQENDPTQLRSPSPGKLVRFLVESGDHINAGEQYAEIEVMKMYMPLVAAEDGIVQFVKQPGVSLEPGDILGILTLDDPARVKHAKPFEGLLPDLGTPAVVGNKPHQRMYHYLDVLNNILDGYDNQAVMASTLKDLIDILHNPELPFSEGTAILSTLSGRMPAKLEEGIRAAFDTAKSKGESIEFPTNRIKKLVDHYMEDNVRAQDRAMFRTQLAVLLDAVERYQFGLKGHETNVIAGLLARYEETEKLFGGSIEARVLTLREQNKDNLDKVAALVLSHIMAQRKGRLVIAILDHVKNSGLTVTDPNSRLYQVLQGLAALEARSSTQVSLKAREVLIACQMPSYEERRAQMEAILKSSVTNSYYGEPGSVVRTPSMEVLRELIDSRYTVYDVLPTFWNYSEQEIIHASLEVYVRRAYKAYTLLSVDYEEGDGMDDGEAPSIVTWRFNLGQSNSPPSTPRLGRDDPPRRQASVSDLTYMINAHQKQPLRNGAIASFPNLAALKRGFDKVASVLPNFDPREYQLRYGANNQPPNVLNMALRVFNEADDMSEDAWYEKIEELVNSHRDVLTKRGVRRISILICRPGQYPIYYTLREMDGAWKEEQAIRHIEPALAFQLELSRLSNYNLTPCFTDNKQLHIYHGVARENQLDSRFFIRALVRPGRIRGSMNTAQYLISETDRLVTSILDALEVVSVQHRNTDCNHIFMNFIYNLSVTYEDVLEAISGFIERHGKRLWRLHVTGSEIRIVLEDQDGNVTPIRCIIENVSGFIVNYHGYQEITTDKGTTILKSIGEKGPLHLQPVHQAYPTKESLQPKRYQAHLVGTTYVYDFPDLFSKALSNVWAKARVTSPSLSLPKKIFESKELILDEHEQLQEVDRAPGNNTVGMVGWVFTLRTPEYPDGRRAVVIANDITFKIGSFGPAEDQFFFLCSQYAREHGLPRIYLSANSGARIGLAEEVMNLFSVAWSDPEHPEKGIEYLYLTHENFLKLGEKTAAAIRTVEIEESGECRHKITDIIGLQDGLGVECLKGSGLIAGETSRAYDDIFTITLVTARSVGIGAYLVRLGQRAVQVEGQPIILTGAPALNKVLGREVYTSNLQLGGTQIMHKNGVSHLTANSDLEGATHILEWLSYVPEYKGAPLSVLESADNWDRDINYIPPKGPYDPRWFIAGKQDESTNTWLSGFFDRDSFQETLSGWAQTVVVGRARLGGIPMGVIAVETRTIERIVPADPANPASFEQRIMEAGQVWYPNSAYKTAQAIFDFNREGLPLIIFANWRGFSGGQQDMYDEILKQGSKIVDGLSSYKQPVFVYIVPHGELRGGAWVVLDPSINSAQMDMYADVEARAGVLEPEGVVEIKMRRDKILKLMERLDATYASLKKDSTDPSKTPEDRAAATDALAKRETLLQPTYKQIALLYADLHDRTGRMEAKGCAKSMTWKDARRRFYWAVRAKVARSAALEQLAEASPESTYDYREHLLESLAGIENESDPRKIAEALEKLDLLNTLTRLKADHLARRMLELANEDKKATVDGLIRLIDNLGDEEKLALIQALQNSNRSPGPPSYASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q266</accession>
    <name>A0A4Q9Q266_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Exocyst complex component SEC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_846365</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the exocyst complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SEC5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q266"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q266"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029175">
        <property type="entry name" value="EXOC2/Sec5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039481">
        <property type="entry name" value="EXOC2/Sec5_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13043">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15469">
        <property type="entry name" value="Sec5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC2/Sec5 N-terminal" evidence="6">
        <location>
            <begin position="49"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="873"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="892"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="915" mass="101739" checksum="533329CFD3FD0E2B" modified="2019-07-31" version="1">MGRLNFDIDDDALLKAYKLSSISATRWEEIEEDTDNAVVGMTGPAENDTDPLGLGATIDLRELDSQTKAAVLISSKTFDPKTFLSVVHPNATYQDLSAGIAHLRASLDSRSEAIRVLVEENFDRFVAVKASTDALYAEMKEGILADQTDYASQPLKDHLKAAAQKADQVFLPVLENAMKAQKLRTTLGVFERSKFFFNLPSSLVECIEAGRYEAAMRDYKKGKILLETRPNQLLPIGTTKDGQAAESAQQQQKRILDKVWATVEKVMAQMRSELQAKLQEPSRSVEEQEKTIEILYEFSSSDDPAWSYFDAQHKYIMQNMRDIYANAVSTIKAGLNDKAPVEGPSQSSLNRELASQLQACVQAIEAKQPDVVIAQSGGHEIWEAIETMVKNVSEAMLTPLPNFWKISKSFMEGRYKKNAASSSRRSPSQCRTMALDIIQLYISLLSEFFMFSDMAVMSPGRNATPPMFPKASNSLTTAHHFMKILGEIQDSVNDVTGIEISGEATSSLKSLLESARWKFEDLLINAWLRDANVFYYLENWVGSTADPYTTVYLAQMRTFQKQITTSAFKICGGVDLSASGSSSRQTKQNPIAPEFVAKITKAFLDSLYAFLDGLVHLASDESPTSATPRAPLLAQANAVPGSNNPLELVKIEDAGTRVLLVVSNFAQLQSALIPSMIAEFEAAFNVTLSDEKNSLMAVVKELDKTLFESYFKPKSTAITSIVRNGILDPEMDWYETPQPKEIRPYVYETLMYLVGVHAQVSAAAAPLLERTLNALVEDVAEEALRCFRQVKRFGMGGMLRATLEIEFIHQVLSRYITKSANETLSELYTRISQTYAKRPGDENLQVYLEGVKKTLSDARHATGIEFLCFRQTKDRSKDKSKAGSSSTAPSGDEGRPRDRGDRERRRERARREGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2C6</accession>
    <name>A0A4Q9Q2C6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1037243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2C6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="230" mass="26151" checksum="8DA8454E65194FA9" modified="2019-07-31" version="1">MEDHRRAAGKRPQEPVLLYARFLPQNPAVPGSRYTQILAPSEHFTQRDRFHRPLRSRNLSPLGSEMSIPISPSRHPTCPTDPPTQLPIDTCVRILPLQLSVPQRHQRLRGDRQPQGRYIPRDGPSFIENHPRRTPPTRTERQSPTGLGPLSDCIQPSDLLTVRGQLRYETLALVPVNLRAWRGQPDRFAGVAAELYACSIPTSRYLSDAIHYPLMRRSTHSERSGRRLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2R7</accession>
    <name>A0A4Q9Q2R7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NAD-aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_921245</name>
        <name evidence="6" type="ORF">BD311DRAFT_655668</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2R7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2R7"/>
    <dbReference type="OMA" id="WVNRYGR"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004030">
        <property type="term" value="F:aldehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07091">
        <property type="entry name" value="ALDH_F1-2_Ald2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="34"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU32183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="504" mass="54556" checksum="BF4AE7C9476C3635" modified="2019-07-31" version="1">MAKPVTLTIPATGKQITVPTGLFINNEFVPSVDSTETIQCINPATEEVICSVVAGSERDIDVAVAAARKAFKTTWGKNVTGFERSRLINKLADLIERDAQELAELETLNNGKPVKIARDFDIGDSVQCLRYYAGWADKILGQAIEVDNKTKLAFTRHDPIGVCGQIIPWNYPINMWSWKVAPALACGCTIVMKPSEITPLTALKLSELIVEAGFPPGVVNTVPSLGSVGGAALSSHKDVDKVAFTGSTVTGRKIMEAAAKSNLKKVSLELGGKSPQIVFESADLDQAANWVALGILYNTGQDCTAGSRLFVQDTIYERFIEIVVQKFKQLKIGNGFDESSGGGPVVSKMQYDKIFSYIESGKQAGARCVLGGEKRPGKGYFVDPTVFVDVKPDMKIVRDEIFGPVLAVARFATEEEAVELANDTSYGLGAGLHSNDASQCMRVSQALEAGTVWVNQYNLLNNNVPFGGKKQSGIGRELGSYALEEYTSVKAIHWNYGEKLDWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2S8</accession>
    <name>A0A4Q9Q2S8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acyltransferase ChoActase/COT/CPT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_920245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2S8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2S8"/>
    <dbReference type="OMA" id="HILVMRR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004092">
        <property type="term" value="F:carnitine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009437">
        <property type="term" value="P:carnitine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.20:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000019">
        <property type="entry name" value="Carnitine acetyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.70:FF:000003">
        <property type="entry name" value="Carnitine acetyl transferase FacC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589">
        <property type="entry name" value="CARNITINE O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22589:SF29">
        <property type="entry name" value="MITOCHONDRIAL CARNITINE O-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Choline/carnitine acyltransferase" evidence="7">
        <location>
            <begin position="30"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="692"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="753" mass="84504" checksum="6831E22DD7635428" modified="2019-07-31" version="1">MSSVTNPVTKFEANPPESRTFARQEELPKLPIPPLEDTCKRYLRALEGLQDPKEHEETKRAVEEFLKHDGPRAQERLKQYARDKASYIEEFWYESYLSHSDPVVLALNPFFVLENDPTPDRGQQLPRAASLIVSSLGFIHDLRAGMLEPDTMRGIPLDMDQYTRLFGTARIPTERGCKMEVHGESRHIVVLRRGQFYWFDVLDAENRPVLTEREVLRNLQAIVSDADQMPIHEVARNSIGVLSTENRKIWSSLRKTLISSKGNEPCLDVVDHALFVVCLDDAAPQNLAELCDNFLCGTYNLKNGIQIGTCTNRWYDKLQIIICADGAAGINFEHTGVDGHTVLRFAADIFTEGLMLLARSINPSAPTLFHAPLSPYAKSYKPPRGQSAPKTAPGYPIDTAPKKLEWTLAPELRAGIRFAETRLSDLICQNDCQALEFKTYGKNFITSHGFSPDAFVQMAFQAAYFGLYGRIECTYEPAMTKAFLHGRTEAIRTVQPHTVEFLKTFFSEAASNSQKVALLRKACEGHVNLTKECSKGLGQDRHLYALYCLLQREREAAVASEMDEDGRPTSPTSVTSSTSNSRDKPSLPAIFTDNGWQILNRSILSTSNCGNPALRLFGFGPVAAEGYGIGYIIKDEGISVCASSKHLQTRRFLDTLQGFLLDIQRILVQLHLSANQRPEPFVDHQGVLRDSKTGRPINGHRPNGSVELSNYDDDDEMMTGYSFFDSGDIELLGRKKDRRTFYKTGKIIPMAEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3Q9</accession>
    <name>A0A4Q9Q3Q9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_946335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3Q9"/>
    <dbReference type="OMA" id="YTYINFG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF6">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020388096" evidence="4">
        <location>
            <begin position="22"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="5">
        <location>
            <begin position="58"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="512" mass="54656" checksum="DCFFEB86F7527796" modified="2019-07-31" version="1">MRPASLAIPFLFGLACDLASAVRLNIHGRPRARPTSELARRAGIVGTSSVSDVGDVEYTTDITLGGKKFTVQIDTGSSDLWVVGDVPNAQNTGKSAKVTYAVGEVEGSIMTAALDFTGNTVSDQAYISVSASQENPDGSGLIGLGPNTGSQVSEAIGTSAGDAVLDRIFKQNTSTPNYITVLLGRVDDPSESPTGDITVGEIIPGYEAITPQPLLNVSVLSSQNSVNQHWQILLDADGIVGPAGNNVIDQYNVQTAVSSTSNKKQLTVVLDTGYSLPQVPSAVAEAFYKDIPGSQLVSRQEVSGNIWQLPCDKEVNVTFKFGGKSFPIHPLDANIDLNLTDSRGNHVCFGAFQPMSSQSDATYDAIFGMAFLRNVYTYINFGDFVEGSTDKTKEPYVQLLSTTNNSADAHSDFVKVRGNSPWTPEGASLGDRIRAHLKLVIGLSVAAGLLIVGGIVACCVTRRRKGPRAPFFQMGQTYQPLHEPAPEAYNMHSVGYQSGYQPSYSNPWDARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4J9</accession>
    <name>A0A4Q9Q4J9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4J9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="246" mass="27630" checksum="2BF7058036F22F70" modified="2019-07-31" version="1">MVNPAYLFVFTERGSAIDEAIFEDWYDNEHIPLRLNLPDNLFAGVTRWTAADGKIPQHLAIYNLSLPDATSHPAYVALAGSRSSREIDILAKLAYLDRRVYVPFGHEPIGAQKEGYDERNPGPFLLVAELNVKDSPEAEAEVERWYLEEHIAEMKKVPGWVRSRVWTVKEVLSVWGTSVDVSAPQKAPARVVALHEWESPEALQGPEVQAAIDTDWSKRLLSDGVIAGIETRLLRYLRGWEGKEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4L7</accession>
    <name>A0A4Q9Q4L7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mur ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_872693</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4L7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4L7"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="523" mass="56378" checksum="4EEA685EA92A7920" modified="2019-07-31" version="1">MSIDLSLDRIRQLLDHLPIPYTRPTIHVAGTNGKGSVCALVASILSAASPPLVVGRFNSPHLLSPLDGIFVRNEPVDRHIFMEAREEVQRRNEEHCCGATSFEMYTCYALLIFERLKVDVVVLEVGMGGRLDATNVVPDESILISALTSVDLDHQAFLGDTVEAITREKAAIARRGKPFVVGPQAHQQVEAVARFIIHSSGGEIAVPCAVVAVDWDPDLDGAPVPTQTGIRVPQFQPVHIHRPCHADPIRALLPLHGEHQLGNLDTAMGIISALQTHPACERPGLNFDQRLTPDAISRGIRATRWPGRLSYHAILLSPASLGTSAIATHENTDPESSQILVLADGAHNPASAAALAAYITSTLGKSGGGPVALTYILALSHSPPKTPEQTLKPLLAIREGLPHKRELRLGVALLPFTPPLGMPWIKFVPPSDIRAAVDSLVPPSGVEILESSSDFGGLDYQEAPIPVEPPRTDHVEEALRWAASRRRHGEDSLVVLAGSLYLVADFYRLLQELGQAGDIWGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q516</accession>
    <name>A0A4Q9Q516_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Enoyl-CoA hydratase/carnithine racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_919723</name>
        <name evidence="4" type="ORF">BD311DRAFT_746092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q516"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q516"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF158">
        <property type="entry name" value="ENOYL-COA HYDRATASE (AFU_ORTHOLOGUE AFUA_2G10650)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU34403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="283" mass="30254" checksum="BD1084CECAAAD5CF" modified="2019-07-31" version="1">MAPSSLHPPSHSDEIQLSFPQEHVLLLTFNRPKALNAVTPTMTSDIKRVLDWFDQEPSLWVLVLTGAGRIFCAGADLVAWNQRQSGGGADSDQSDIINEADGFASLSRRTATSKPIIAAVHGGAYGGGMEIILNCDIVVASEDAKLALPEVKRGVTAIQGGMPRLARIAGHQLASELLLTGKAISATEAATRFGFVNQVVPKDKVLSAALAWAHEINQNSPDSVQSTKRALLLANRHGSVEDAVIAHVGSAESKRAFTSENIQEGLRAFVEKRKPAWKNPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q590</accession>
    <name>A0A4Q9Q590_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_918640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q590"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046921">
        <property type="term" value="F:alpha-(1-&gt;6)-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132">
        <property type="entry name" value="ALPHA- 1,6 -FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13132:SF29">
        <property type="entry name" value="ALPHA-(1,6)-FUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="664" mass="73376" checksum="88459D56898C0D2A" modified="2019-07-31" version="1">MPTNRTPPDIFVTGRPSHSDYRLLTPRTPHSRAGRAEEGFTDFELQAYQDDESNGWKEQQQQQSQPLLSPGYRSRGDGDAAAKGTETRSVHYWIQLALSKLPLVGGVFLAFMLLAFIVVALTSPGKLDSTFLAPPGEFMETIDGDLVASTFKEPSPFSSASGTAPVPTASTPSHSEPHVQLISYENYTQFPLTGNQYRAECNKLMGGFMSHGEYWQSLHGEMDVEHHDDNTNYHLPEGGFTKVCSKTITYLLDGHVGLVADLALMAQAAAMARERNRTFLIDDTHWNRGKWTDYFQPVRGLDPGPEPFCRAPPPEELVACPRTARHWVISSRTAMYHFGHEFFEGYEDPYSHHLNRLKPIFERARISFEEAIRPNAHTAELIRAARTELLSTLSSPPTSPNLGSTNEPANQTAAMRGRDPAPRSDDTSHPPHNNPAPYVGVHIRRGDRRPAAFFFYPGQTIPLEKYVTATRQVWDRFYGNASSSATTSAGVSPADIGDAHETDLSSAQEDKYPAPPVTWLASDSPSAVREFTGNFSAATAIFSLNTSTNAELRALAPTREYVQGGFELEPEEERVRLTRGMVVDLAMVSGLWAYPGEVVPGAVVCAEGSNVCRVSALGFGFERAFGFDDGDDHHDGNPNKVRARWVDVDVEARIVPAWHAFELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5C4</accession>
    <name>A0A4Q9Q5C4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small nuclear ribonucleoprotein Prp3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_843433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5C4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5C4"/>
    <dbReference type="OMA" id="VIYCEGA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="169"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="290" mass="32591" checksum="5B4049F17A3DC606" modified="2019-07-31" version="1">MTSLRKSLEEIHLLRYSLLPGELLEFTDQAALWNELLDAYALDPDCEIGCEPQGAHFRVKLEASSDVWFDVELPTDYWTAEGKGQPRLSAQGDNLGRAQQERWQEIVADAATTVRVQDSEYPLYEMISSHLLPQLHIDLEEQANATAAKATEASASSGGPSPSPRYHALFVSHHLKSPQKRRALSQWSHELSLVGFAKVGYPGVIYCEGAQEDVEDFVERVKSMQWLALRLRFIESAPPTDESQKQDSHHGRWSEFEKVGEVVEEMRRLGREQFVVEMGLGSAGNARPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5Q1</accession>
    <name>A0A4Q9Q5Q1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_700769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5Q1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6626" checksum="6BB475DEE5E5DEC3" modified="2019-07-31" version="1">MTSREMTVVSAQPYDRSFGDRIRSYTQHLVATIGSLCCPLAVNVSLICVLVRSSKSFARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5X9</accession>
    <name>A0A4Q9Q5X9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_919258</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5X9"/>
    <dbReference type="OMA" id="HPANITE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020211692" evidence="7">
        <location>
            <begin position="20"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="303"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="573"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="608" mass="65130" checksum="A4E78327111E3461" modified="2019-07-31" version="1">MFSSPLLCLYVFCITHVLGAIFESPTPEILNSKYDIIIIGAGAGGAVMANRLTEDNSTKVLLIEAGGSDFMNTNILAPGLATSLSRSKFDWNFTTTPQVGLNNRSVQYPRGFVLGGSTAINLMIYSRGTIDDFNRVANVSGDEGWSWNEMLPFIFKVDNMTTPTDGHNTTGQFNPALHNTDGVVDISVPGVSLDIDARGLNASQELPDEFPFNLDYNSGNTTGFSWTQATIHDGRRTTSATSYLAEAFNRTNLDILVNTRVTKIAPVGEVNGVPDLRSVQFAQSANGTLYTLEAAEEVILSAGAVQSPHILMLSGIGNKDHISSFGIKTLVDLPAVGTNMQDHVFLGNSWLVNSNFTLDDLHRNATLSAEQLQIWEVNGTGLIGLPPTNQFAWLRVDPSVFQSLNATDPSAGTTSANFEMIISDNFASKRVALPAEGRFLTFVTNVVSPSSRGNISLASANPFDAPLINPNLLGTDVDVAIMRSAIKAARAFAAAPAWSDYIISEFGAFANATTDEELDAYIRDNADTVDHPVGTVPMGKGCEGALNADLTVKGTAGLRVIDASAFPFVPSGHTQGPTYILAERAAELVKASLGQQERSRHHRGGNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q604</accession>
    <name>A0A4Q9Q604_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_50848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q604"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="7979" checksum="6B4B219809A1CD2C" modified="2019-07-31" version="1">MKTVNHPDAEGMRAAERPYGVSVPFRGGNGISAYPPHASETHAIATTPSKGEIGSPIVRHLFDRASNANSHQTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7D6</accession>
    <name>A0A4Q9Q7D6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_916296</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7D6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7D6"/>
    <dbReference type="OMA" id="CEPEDAP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="225"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="259"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="374" mass="40935" checksum="8B167B0D654FCD59" modified="2019-07-31" version="1">MSKVVFVGNVPYNMAEDQLIDVFKSVGQVVGLRLVFDRDTGKPKGYGFCEFADHETAASAVRNLNGYEIGGRPLRIDLADSDPFLEGKTTVRGEIIDGGETRAQWRERNERERHDRDRYGDHHDRLGRSNDPNAFLQHLPKGVPLPHGSNALDAISHVLATTDPGQILEVLAQMKAFIITHPEHARALLVAHPQLGYALFQALLLHKIVDPAILQRMLAATGATIPPATSAPPPTQPSHPAPPSYMSTPALPPGSMYAPPMPPAPTPMQHPAPPVPPPSMYGQPPPQMPPYYRGPPPPAPPPVAAHPQQMPPAHMPPPVMHSQQPAPPRLPDLDQAQRDILMQVLNLTQEQLNTLPPSERDPILQLRRQFGVDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7J1</accession>
    <name>A0A4Q9Q7J1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_918706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7J1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020895517" evidence="3">
        <location>
            <begin position="16"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="375" mass="39804" checksum="4D3E85CC559A0C82" modified="2019-07-31" version="1">MRLYTLVCLSGLAHASLTLGPESQAFQHLDQNLAGEGRALDGLGLLNGFGGDTREHPSASITLPFVPTLAFPTSSDAADDKKKTKTSDSTTTSTGTSSIIGTPSPLTPTAPSSLSGSPITSHAPSASPNMTSAPVPPNNSTASSGTSEWKIIGVAVIAFSVVAAILLLSVFFDHWWRFVRDIVWRKRKKVSDEELVPDWEKAEWELRLARDPELARYPSFASFPSSLPSVPIVQHAAQGQTSHTQAPVSGPMPPQSALGRSASRREAQTKALERGVGDQQEQRLARRMSVSRQHQHPASSAGIAGVGTGLGLGRVDSVKKDARAHSTPQKADAGRTSPRRKSTQPGRAGAVKEEDPFADVHSPTLMPEDVYGGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q811</accession>
    <name>A0A4Q9Q811_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_868695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q811"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q811"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="301" mass="32668" checksum="840A11E2E517F7D0" modified="2019-07-31" version="1">MSKNIPEQYKKGYKPPFQTQDRAPGAQHKLNPPPLDDITADGKPYKPAGKLEGRKALITGADSGIGRSAALLFALEGADLTVAYHPEEGRDFKEMLDTINKKTNGARKIVSLAYDLRKEEACREVVDKHLQAHGKLDALVLNHGTQQAVKYLPDLPTQQWLETFDTNIHSFFYLCKAAIPHMGYGSTITFNASINMAVGHPELVDYTATKGAMVAFMRALSNQLVGDKGIRCNAIAPGPIWTPLIPATMTKESIETFGTSVPMGRAGQPVEIATAFVYLSSADSSYISGQVLHINGGVVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q812</accession>
    <name>A0A4Q9Q812_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_955583</name>
        <name evidence="7" type="ORF">BD311DRAFT_772107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143605">
        <property type="protein sequence ID" value="TBU21459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q812"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q812"/>
    <dbReference type="OMA" id="LIMVTRN"/>
    <dbReference type="OrthoDB" id="284718at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005351">
        <property type="entry name" value="ASTER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03669">
        <property type="entry name" value="ASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU21459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11664" checksum="D227F6933B8B0C5F" modified="2019-07-31" version="1">MATSVAVAPGDDPRDPSAEVKLTLPDTWQVESMDPLGSSMMFVSGLIMVTRNRYLAWPSLLLSINSVTNSHPLRVKEGAQTGLSVIMLGIGALLASYLPLIMITPKPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q843</accession>
    <name>A0A4Q9Q843_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zinc finger CCCH domain-containing protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_810000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ZC3H15/TMA46 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q843"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q843"/>
    <dbReference type="OMA" id="GREMFYF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000050">
        <property type="entry name" value="AGAP008634-PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="13">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU62774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="39772" checksum="0C21EBEC29CE87E0" modified="2019-07-31" version="1">MPPKKQQASGGSKPKEDKTFGMKNKNRSAKVQKEVATIQKQQALAGKSRAVLEKEKEKAMREKAKLEEEKRKKEEAALIKPVQTQKVPFGVDPKTVLCAFFKAGTCEKGSKCKFSHDMNVGRKVEKKNLYEDSREDKMKDTMENWDEEKLRKVVMSKGGNPRTTTDIVCKYFIQAIETEKYGWFWECPNGESCHYRHALPPGFVLKSQKKAIEDAEKANAISLEEFLEVERHKLGPNLTPVTPETFAKWKRTRLDKKLAEEDAQKKAKDEKHAAGKSSGMSGRDLFTYNPEWFEDEEEADEDDWDLAKYRREKEDADIAAEEERIRNLQLGGGGTVATSEVAADDADGGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q859</accession>
    <name>A0A4Q9Q859_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mg-dependent DNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_522385</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q859"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q859"/>
    <dbReference type="OMA" id="YGGSQKH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="37478" checksum="5ED816B92C54AF32" modified="2019-07-31" version="1">MPVTVIAARPPEQTSAPSNHRYIDIAVNLTDPVFRGYHHGKRKHEDDLDAMIERSRAAGVKSMIITGGSLHESKEALELASQLGFYATVGCHPTRSKQFDDFRGGPAAYLEELDKLIAANLTGKGRVVAVGECGLDYDRTHFASREVQRRHFRSQLSLAKEYHLPLFLHSRAAHQDFVQILREEGYDKDGGKEVGGKGGVVHSFTGTPEEAKELMDMGFHIGVNGCSMKTEENLATAKSIRPQWIMFETDAPWCSLTSTHASKPHLASLPPSLGSLYFPQATKPESFVYGRPVKGRNEPTAIGGVAWVIHRLTEGVPFEKVTEKAWKNTVELFGLTELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q865</accession>
    <name>A0A4Q9Q865_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_915779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q865"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q865"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="161"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="664"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="297"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="688" mass="75998" checksum="089CA278376B4FFF" modified="2019-07-31" version="1">MPPKGRNPNPSGLGRAIINRKAKDARIAHETGIYTTDPESTRLQSITQERDLDEFLNTATLAGVDFTAERRNVKVIAAAANAQQNPYLLSEEEERTTLRKQSENKQRLRVPRRPPWTKSMTTAQLDRQEKDAFLEWRRGLADLQDRDNFLLTPFERNIEVWRQLWRVLERSHLVVQIVDARNPLRFRCEDLEAYVQDVEGAEGEAETGTGKRRSLLLINKADLLTAQQRKLWADYFDSQNVKYAFFSAANAAAIQEARRDAAAANTPQHVLEAQADAETRSGEQAPGAEFTPAVDAADADDESDDESESPAEDSDEETSSDDDTQSEEGGAFLPIEEEPEASDPRTKVLSVLELEELFLRTAPDLSTFTDSSGQHPTKLVVGLVGYPNVGKSSTINALIGEKKVSVSSTPGKTKHFQTIHLSPTLVLCDCPGLVFPQFATTKADLVCDGVLPIDQMREYTGPTTLVVRRIPKEVLEATYGLSIRTRSIEEGGDGRISGPDLLVAYAIARGFTRSGQGNPDEARAARYILKDYVNAKLLFCYPPPGVPEDEFNEQTRQLALRRAMGKKRAPTTRVTIKADTFVAPAAPDDSAPATNSSNKSRKLDQEFFANGTLSSRPHMQGARGQGQEFSRSKLYPHQNMVADDGTPLTGRRARIAAVLAAGGDVAPGKKHHRKMKRVKQRSGKGYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q868</accession>
    <name>A0A4Q9Q868_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec3-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1035485</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q868"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q868"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="40"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="303"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="695"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1144" mass="127018" checksum="088EB27BAB811FF8" modified="2019-07-31" version="1">MAEGDSIRQRIVSSVFITKLVDETYVGHIKIWEEDATDDGGKKPRYIILSKSNNGSGFIHKSKLNSNGSFSVGKTWKLLELRGIEVLNPLAFNITMSRTYRWQTENQKDQSSFISDLIQLFRSVTGGNAPLELVGVRDPTNETSSRPPPLAFSRMERAPTPTNGVPLPPTTPRRSAAPVNGYSEASPSVSYTNGRMSSISNYQPSTPGPRPPPTAIPERAGTPSRTRPSTPSREPFPPPSALRPRHARLPSNATTETSSRTSAATTSSQVPSIAYPSSVTSVQSEPQAQYTNGFRATRDTGALEIPTRSGSPASIVQPSPRSAYAVSPDGLVPSQSITPTPSARATPSRTTPARQMTESGQRRENTRVSFYDPPNQATLNRVLSGDAMLHDAGDDDGEGTGEIEDESARATLESVEEMLEGYEWASDDILGRRALTGTAEQIEARLLDELMALDKANIHSFIESDDRIVTVLKLLDDAINELDNMESVVSSYKIHLNAVSDDIAYIQGQGRGLQVQTQNQRALLNELEELLQTVQVDSSSLLALTQESLEHAWNIQKLETAVTVLYKALLAGRDRDMAATMERLDEYKKYNAQFCKRVLDYLSIVFTAQGKMLLGDDNGVARPMRGRVTIKDHRNFESYLERYRSLLLYLKEMDESAYAKICAAYFSAASELHATQIKALLSIYGNMVKKAPTEEEAEGFSGTTPTSNASKAAQGMRRAGTIVRSPLDRREKKEASDGELRAAEALSMVLEQLAGTIYAEESWIARFLQMDDAVETFADHMGLENYFRRQAARWAGLSQATTKLVRGAMDLIFGFLPLELKAWLDSAIARDSLQVVGMLVSLEKFQSEAEERGNTFLLSLLEKQHMRLKALFERRVNDQIKSIEETKLTSKKRKGVAQFIKYFPTYISRVETQLIGADTLEIRQTVDAAYDRIVQAMFDALKQMAKMGGDEEDKGQLNYHVILIENMHYFVAEVSQIEIGTVAVFLKRAEAIYEENLNAYVKIVLRRPFAKIIEYFEGVERLLKTTAPSEISSNSSYSKSSLKKVVKEYNVKDIRKYVDALFKRVEKHFDEASEKTTSEDASASTGIAPGTVLVGVWKACEEELMRITGLFNKTINQCYRDTGVTLEYSAADVEAAFKRHRVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBF3</accession>
    <name>A0A4Q9QBF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1034998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBF3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBF3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF32">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="237" mass="25863" checksum="6E62D6A8F2F72185" modified="2019-07-31" version="1">MSSASKVVLVTGANQGLGYWALHISALRQPSYTYILCSRDINRGKEAVQRIKDAGVTANVDIAAAVKYVEETYGRLDVLVNNAGILTRTPEDDLPPSAIRATYNDIFNINLTSVAVISTVFQPLLHKSADPKVINVSSGLGSIQNALTEKMNLNVPYGASKIGLNGLTVHMQVAENNRLEAETSAASPISPGKPKIRYYDPEVGAEVIYRLLADDEKTYEGGSYWEFEQGEMRTVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCS5</accession>
    <name>A0A4Q9QCS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_911453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCS5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCS5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="7">
        <location>
            <begin position="88"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU65499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="495" mass="55227" checksum="B071B3BBEA4F99FA" modified="2019-07-31" version="1">MAESRFEQQVHEVVRHFRHEKDSEAHRLFRQSAGHNKPKGGAALPQTVNPDEETIPGIEHPGSTGVIYCSDRAMANGFSYASSHEWANLGQGAPEVGLIPDAPPRPTSIPLPEDSLEYAPTTGVKELREAVANLYNQQYRQDKISQYTYENVCIVPGGRAGLSRVAAVIGEVYCSYQVPDYTAYDQVLSAFKRLVPVPTALDEEQQYRLDVNQIKRDIRTQGLEVIIASNPRNPTGQVIQGEELKSLVATCREASTTLILDEFYSWYLYPEKEEEYGKSVSSASYIDNVNGDPVVIVNGLTKNWRLPGWRVCWVLGPKNLITALSQSGSFLDGGANHPLQLAAVPLLDPQRVHEEKIALQKHFKAKRDHVLKRLDELGLHVAVPPVATFYIWLNLERLPAPLNNGLTFFEELLKEKTIVIPGIFFDINPAHRRNLFHSPCHHFVRLSFGPPLEDLDKGLDAIARVLKKAKKEGGHAFGHSYKKSVDGSSQADKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDQ5</accession>
    <name>A0A4Q9QDQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_953479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDQ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDQ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF745">
        <property type="entry name" value="F-BOX_WD REPEAT-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="280"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="529"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="612" mass="67540" checksum="E2F163255B74D6F1" modified="2019-07-31" version="1">MPFRAYLADYERRHGPVTDHTGYSGGGGGVETGRDVREREELAFRILASLPRSSLAVLQHRIEPLLKLDIVGLLPTEVALEVFSYLPYQSLLTCALVCTRWRVLADDQSLWKSLCLERKWEWRVRPDAHETDARSPPDEHVESDLDDEGMGDEEDDDLMHVDDSGFASMDINGDDTVRVGLPSTSSFSATAHLSLTINSSHTLPDLLAGPSRGRMRSPRERHSAPSILHTSAVQKLALASPPNPDPKPDYKILHQTHVKLRNRFTTGQYTLSNLQTRGAPNGHTNTIYCLQLYTYPESGTQVLFTGSKDRTVREWDLQTGAVIRVLEGAHESSVLSICAHRGLLASASSDRRVVVWDLVQNKVIRTIRDHEDSVLCVRFDDKRLVSCSKDRTVRTYLFPHLGQQHVLSAHRAAVNAVSIANKHIISVSGDRSLRLWDADTGACLRTFENHHRRGIASIDYKHPFVLSGSSDKHIRLLDVSTLQGWSTNPAVTDKPAAAAPGGLGRTVPVVCESCGSSTSAGEPSQPPRRRAHEDLVRSVALSSDLVISGSYDFTVKVWDRKTGALVADLAGGHTGRIFCVGSDCTKIVSCGEDQRICIWDFSHGIDTSFLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QGN0</accession>
    <name>A0A4Q9QGN0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_912780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QGN0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU66104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="165" mass="18690" checksum="5831F31D662C0942" modified="2019-07-31" version="1" fragment="single">VTASRRDIPSAYPPNDIQGCIMRCLRDHSTRITDERIIHLFCRLPPPALDARLRPASFTSINNNPHLILPIRYSWGEEEHNALWSLEVFVRTYVSHRPAVASDTVATKIVLRGPWRGADGLGRWLPLVWSAPSAYEDDGDCFPFSTSEHWGKITIRTSVRSTLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K0M5</accession>
    <name>A0A4V2K0M5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_914979</name>
        <name evidence="10" type="ORF">BD311DRAFT_262721</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="ML143412">
        <property type="protein sequence ID" value="TBU29483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K0M5"/>
    <dbReference type="STRING" id="114155.A0A4V2K0M5"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU29483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="469" mass="53036" checksum="A1E18FE747FEF8A0" modified="2019-07-31" version="1">MRNELNRLVNTVSDPATRKAFDTEMQSFFYLFTRYLAEKAQNKEIDWERIKSPAADQIVSYDDLPATTDPKSLDRLAVLKVNGGLGTSMGMTGAKSALEVKDDMTFLDLTVRQIEHLNTTYRVDVPLILMTSFNTHDDTLRIIKKYANQQLRITTFNQSRYPRIDKETLLPLPRSATDDKSKWYPPGHGDLYNALLHSGVLDQLLAEGKEYLFVSNSDNLGAVVDQKILQHMIDTNAEFIMEVTDKTKADVKGGTLIDYEGNVQLLEIAQVSSEHVEDFKSVRKFKIFNTNNLWINLKALKRIMENEGMELEIIVNPKVTEDGVSVIQLETAAGAAIRHFKNARGINVPRSRFLPVKSCSDLLLIKSDVYSLEHGELVINENRMFGTTPVIKLGDHFKKIAQFQKRFKKIPKIIELDHLTVTGDVYFGRNVTLRGTVIVVANEGQRIDIPDGCVLENRLLSGNLTMTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6L8</accession>
    <name>A0A4V2K6L8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 105 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_962448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145239">
        <property type="protein sequence ID" value="TBU52723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6L8"/>
    <dbReference type="STRING" id="114155.A0A4V2K6L8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010905">
        <property type="entry name" value="Glyco_hydro_88"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052043">
        <property type="entry name" value="PolySaccharide_Degr_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33886:SF8">
        <property type="entry name" value="UNSATURATED RHAMNOGALACTURONAN HYDROLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07470">
        <property type="entry name" value="Glyco_hydro_88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="375" mass="42914" checksum="0E066A04F0900DBF" modified="2019-07-31" version="1">MSFRNVNPAKVATIKHINNLITCLVNIRDETGEFLMPLADGRIIDTKGWEDWEWTHGVGLYGLLKFHEITGDQRALDIALKWFKDRFEIGTTKNVNTMSPLLTAAYLHEKGVADYFVHLDSWAEWVMYDMPRTEEGGLQHITYLTDNYQQLWDDTLMMSVLPLAKIGLVLNRPHYVEEAKRQFILHIKYLQDLQTGLWFHETTLLPGWTFDGRHHFGKVRWGRGNCWVTVAIPDFIELLGLPETDGVRKFLTTSLVAQIDALVKYQDTQTGLWHTLIDDPSSYLEASATAGFAYGISKALRLRLIPREEHYVDTARKAMKGVLANISEEGELKQTSFGTPVFHDAEQYKEIPLTTMPYGQSLALLALTEHLKTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7G1</accession>
    <name>A0A4V2K7G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_883362</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7G1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="143" mass="16168" checksum="7057E4FB02C134B1" modified="2019-07-31" version="1">MGFEGLWATRTLAPHKRPDKSQLARAEQASTDPLRERYGISNTLTYSQHGRSVDGHWEDTGKNVSSILWVIDEQNLSVTTITVWVLSPRRLWVMGYWGPMGYGVEFPLSRLGKAKILWVFGVYGLPGVWVRRVSTVSAHAQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7Q5</accession>
    <name>A0A4V2K7Q5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_930191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7Q5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="2">
        <location>
            <begin position="278"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="512" mass="56436" checksum="9B080CD340606647" modified="2019-07-31" version="1">MPIHARTTSSGSHDGSESSLTSLASSRSERPPQGHRPPQTPPGGNKPPGLTFSPSGSSNASSPTSTRSYGLSTEVYPYEASALSNTVRTILESSAESDRDDALYARAQRHLQVLNDPLYNQYDTPQWVRRRASSARAVLFQGFTVRGLIKAMYATAEDLGLERGKRYVSAAICACADDARRAPDNVDRLEFLAQGLERLASTWAAFMLWPFYAQQENAELIVGLDDISGNATPTETNTESIIDDVGLSKNRSGELRGDVGRREGHRSVITGDMDVYLSTRNRPEGVATAYLEVAHIFKRALVVYNRNTAKQRTRSITATLEILQHYCQLDEKYVKDIGLLDSPVNAFLVDSGSVHKAFDDFLWCLKPTEIPNQYEYKEYDHAINLRYNMPTVVVFKDHSIEDADTAISTQSSTDNPSEPGTSRASRHRNRPHDAMGVELPDPELFRLHAALAGVLNMSGAAGIFQLIMDRQNPGQPPVPSADGEAFFKEIVEDNELGALRQSIAEMWSTPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K804</accession>
    <name>A0A4V2K804_9APHY</name>
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        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_497711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K804"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="296"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="869"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="785"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="896" mass="100128" checksum="46ED4C724BE81B2B" modified="2019-07-31" version="1">MEYIEEAEDQWFLDCLPGGDPPAGTTFSRWTVDFDNKEEGMYPGLARGLNSSLATVGWIAYTARCTHRLPDPTASGPRHTSGTNTFCPDLGIYPVDCPAHSQAGAGDRFRVSWPHIEVVIEVKKTSSSTTMTTADAPTSPLPLPHQSDRGQLIDYGIEVLNRQHRLFCFAIVILDDTARLLRYDRTGITMTSKFDYLERPEVIGRFFYRLSLATRMERGYDPTVVPSSAEEDKLFRGLSARFTPGSAESQALVNATSTGWPTNKITIDAPFSDGEKAVSRHDAILERHFLVGKPAFMGRSLVGRGTKAFVAYDMANDRVVFIKDSWRPDTGGRTQSEYDIYLQLREKIPKRKLYIPTLLGGGDVKFEGRQQQTRTPATRYLPRNHVRLVLWEVCLRLEDFTQSLELVQVIYTAFRAHYLAWSKAGILHRDVSAGNILIHQSGHQRVGLLADWDLAKTRAELEYPATQEGRSGTWPFMSACLQQFPGRPHTLADDLESFVHVLNWCLLKYIPNALSSDRRQLLRHIASVYDVASDDDPEKGSIVKYNKIKDGELFVKLTDKHPLIRPLEKLAALCKNHYYHLSLPRLANETSLNILPVQDVFVLDDLEDDTGVQSRSDTESELSEASGLSDSPHSKQSSSSRNDARQDPPDASRSPLLHHKEMDRVLRKVAESKAWPLDEGKYNGPDLVWDDQPSRSSNNPSTEPVGAPGSGSKRRKLDGVSSDNAASRSGGSRVSQRSQSSASRGSGGRGKKTSRARTSKISRGRSARALWDLASSEDFIDPSMLSDTSYSRSASPASVGYEQEEDEVEDSLMVEDEPGPSSSHLPPTYFYAERRLMNQERLQLNLGRLQMEPQEDLSILERLRKAVSRLPSPGHEESEEIDLPASSEYKGKKRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8Q3</accession>
    <name>A0A4V2K8Q3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brix-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_874469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8Q3"/>
    <dbReference type="STRING" id="114155.A0A4V2K8Q3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="129"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="383" mass="43378" checksum="7B97A3364A5AC479" modified="2019-07-31" version="1">MPPSRFEPSSIRNKVKREEIARKQKKEKRQGKLQRRLAQAKAEADDPLLKKKRLTQNVPRTLDNTREYDPSMLTANPNAEPEAGPSSLLQEGEETDQPVVQPEDESAADIAADPFAEYFSGALDPSTPPKVLITTSPKATRLTYDFCDELVGVFPGAEFIRRKKGKGFEMGRIAGWAANRDYSHLVVVNEDMKKPNALTVVHLPEGPTAYFKLTSIELSQQISGHARSTAHFPELVLNGFVTRLGHTVGRLFQTFFPPMPEFQGRQVVTLHNQRDFLFFRRHRYAFRSTEKVALQEIGPRFTLKLRYLKKGLPAVKNLGAPSKPLEFDTGEDEEAERKDAPEEGMAIDGESEAGKKKVLPPTDDEYLWIWKPELETTRRTFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8W3</accession>
    <name>A0A4V2K8W3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_171082</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8W3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="7951" checksum="A59964912F41F62B" modified="2019-07-31" version="1">MRSSAGEGLLTSANWVITGVATAITISQIFYLRNLTIPSGTPRRPGTSTEAYSSLCASWEDRRRVGSAVQVSSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8X6</accession>
    <name>A0A4V2K8X6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">DNA topoisomerase</fullName>
            <ecNumber evidence="3 12">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_845467</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 12"/>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8X6"/>
    <dbReference type="STRING" id="114155.A0A4V2K8X6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 12 19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="12"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="18">
        <location>
            <begin position="172"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="17">
        <location>
            <begin position="760"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="GRF-type" evidence="17">
        <location>
            <begin position="835"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="922"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="960"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="15">
        <location>
            <begin position="991"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="622"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1002"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="642"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="734"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="895"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1010"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU61718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1055" mass="114241" checksum="FE2D3B36F3058928" modified="2019-07-31" version="1">MLQAFCYSHMMRVLCVAEKPSIAKSITQILSGGRFNTRNSRNKYIKNYDFDYPQTNAHFTVTSVTGHVMDYDFNVMYSKWTSCDPFALFDAPIECKVKDDAKTIADNLKTEAARAQMLMIWTDCDREGENIGAEIARICQRSNRNLTVRRARFSAIIAQQIHNAAQHPVNLDMAQASAVEARILLDLRIGSAFTRLQTLNLQRRYEALKKELISYGPCQFPTLGFVVARYNKVKNFKPEPFWYIFLSLTRPSSDEEPVDTEFTWRRGHLFSLPAAWGLYEAALEHPVARVTKVTSKETKKWKPYPLTTVDLQKAGSRLLKLSPKKILDIAEHLYQQGFLSYPRTETDVYDPQFDFMSLIQKQTADPAWGGFASGLREGGFTPPRRGKNDDHAHPPIHPTAHAGNLVGDEKRVYEYIARRFLASCSKDALGWQTTVDVKYGEEEFYATGLTIRERNYLEVFPYDKWADKELPQFQEGEAFVPTECRLDEGQTSKPKLLTEADLVSLMDEHGIGTDATIAQHIQTIVDRGYVHEKMQGATKYLIPSTLGIGLVEGYDAIGFEQSLSKSELRRETERQMVDICQGLKSKNEVLEESIERYKEMFMRTKIEFQKLLQAVGNRINGQGPVPEIDLGEAHDSDDDDNGGGGGRGGGRGGRGGRGSRGITRARGTARGAASTRGSAAARPKRSRGRGAGLAAGRPPPPPPPPPAAPPAALNGDDSDDYWSDDPPPPPAPAPRAAVASRPPLSRNVPPSNAGGAEPQCDCGIPAAERTVTKESANKGRRFWTCGDNQSCQFFQWFDGPSNSSSTSSTSRSVPSKRPFSSVSAAADDVGADRRCQCDLTAVLKETATGANKGRKYWSCPNQSRQAQCRYFEWAAEDGDALVAPPSRSYSTWSGTGKGPGSYGGGGGDGGGGGGAGGGSGGCFQCGEEGHWASACPNSGAKRQKSSGDTGGGGGGSSGACFKCGQEGHYSNACPNGGRRDAGGGSGSGNACFKCGKQGHFSNACPGGGKSSSSSRRSSSSRGGKRGRGRGGKSGSSRGRKKSTGSFSVADDYTDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K931</accession>
    <name>A0A4V2K931_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_974484</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4V2K931"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="240"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU62308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="338" mass="37944" checksum="21C7D8E22B280D84" modified="2019-07-31" version="1">MPVASSSRSKKRHARAPSSDIEEDSGPSQHKQNTQEDVEMDEEEEPRKAKKSKKDKQRAAKDDSDAEGEEEVEEDLPVPEINDQPLDKNQAMKIRQMASDWGYTRDKVHNASYGFLREVAASVAEFTEGEKGEKALKQIDALMRELLDTEQHLNAHEQALDEIHQRLMRGDKIAGVAEAYEKGVQEKVRTYKAKTSRQKYAKSDNYTKFKQAVYEVHNPDTAMPPLVDLIPREEGDDSDDEDDVQIGGITQDYKCPLTLTHLIDPLTSKLCGHSYSAAAIREYLGKGGRKECPATGCKKMLALSDLEADPALAKRAKEAARRERARESDEDDDAEVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K938</accession>
    <name>A0A4V2K938_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleic acid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_811399</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4V2K938"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000047">
        <property type="entry name" value="tyrosine--tRNA ligase, cytoplasmic isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053836">
        <property type="entry name" value="Arc1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21972">
        <property type="entry name" value="Arc1p_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="9">
        <location>
            <begin position="235"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="132"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU62338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="43999" checksum="652443C0E4CF9D44" modified="2019-07-31" version="1">MSVQASIAKLAPPLRDLVSGVVQDGSEDFGKSENDKAEVAQWIDTVAQGHVAKAENLKDLEASLVPRTYLVANYFTAADSALYGALHPVVSQLQPAQYYSHPAITRYFDHVQHRPSVRKAAEPLAPAFSVVPFDLKNAPPQERKPEPPKEKKSKAPAAPAAPAEGDKAAAKPEKAAKAAAKVDKAAKKAQEEGEKAAEGGEKEGKAQKKEKKAKEPKEPKAAEKKPAADEAGPPIPSMIDLRVGRILDIKKHPDADGLYVEQIDFAEPEGPRTVVSGLVHYIPIEEMRDKYLVGVCNLKPANMRGVKSFAMVLCATHKDGKDAGIELVQPPSGSKVGDRVYFEGFEDKEPLSQLNPKKKIFETIQPGFTTLETREAAWVDPETKSVHKIRTKDGVCVAPNFVGASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K945</accession>
    <name>A0A4V2K945_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K945"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12468" checksum="3B2A3285754D8922" modified="2019-07-31" version="1">MSPTLVMGDMCRPLKDVLSKSLTNGSRTYYVGDGAAIVWKLSRSQWKAYIQSTLIATFSPYPPRSLVVQPLGHRYLDHILLGILLLMRDKDAEVFDRPENSYSVMPFPCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9J3</accession>
    <name>A0A4V2K9J3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor 1 alpha-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_1014363</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Dom34-Hbs1 complex, also named Pelota-HBS1L complex, composed of dom34 and hbs1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9J3"/>
    <dbReference type="STRING" id="114155.A0A4V2K9J3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990533">
        <property type="term" value="C:Dom34-Hbs1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002184">
        <property type="term" value="P:cytoplasmic translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16267">
        <property type="entry name" value="HBS1-like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04093">
        <property type="entry name" value="HBS1_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000204">
        <property type="entry name" value="Translation elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="54"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU64168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="510" mass="55405" checksum="FDF131D5DB62F204" modified="2019-07-31" version="1">MTVDQRQLDIAGLNLDDDDPLEVILDEPAKPPAVVEKLIEEAKAALTAQEKSEKRSLSLVVVGHVDAGKSTMMGRLLYELGQIDEKKRVANERGSAKMGKSSFSWAWELDGTQEERERGITMDIALQTLNTPHRIITILDAPGHRDFIPNMISGASQADSALLVVDAAVGEFEAGFDRGGQTREHLLLVRSLGVSQVIVAVNKLDQVEWAKSRYNEIVQLLKPFLVQSGFHPSRTKFVPVVAMEGVNLTRREPADCPLFKWYEGPTLVDLLDALDPPTRDINAPLRFPISNIFKGTTSGITVSGRVCGGIVVAGERLRIVPGDESATVKLIDNDGESLPWAGAGSNINLILTSVDPVSLNIGSVLCRPGSIIPLTFSFIARIIVFDIQIPITAGTSIELFHHSLDVPASISRLISVLDRSNGNVIKSKPRVLTKNMSAEVEISLRGSLYSGPASRALPIPIEPFSVNKEMGRILVRRGGETIGAGAYHPLRAHQLRLIIGRLGVVMELLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWU2</accession>
    <name>A0A4V6MWU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Amino acid permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_876661</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWU2"/>
    <dbReference type="STRING" id="114155.A0A4V6MWU2"/>
    <dbReference type="OMA" id="INMMGAG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="41"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="546" mass="59612" checksum="561C207CFD6C2E0C" modified="2019-07-31" version="1">MSVENEKEGSLTVRKAPESVSSDFEGEAGQNVLRRKMKNRHIAMISIGGIIGTGLFLGTASALQSGGPVGMLLGYIVVGSLCYTVMVSLGEMAAFLPVPGGHLTFAERFVDPALSFSLGWLYWYNWTIILPAELSAASVVISYWNKTVNPAVWITMCLIVVLLINVFGVGVYGEAEFIFASIKVITITGLIILGIVLDLGGGPSHDRIGFRYWRNPGPFVQFDGISGIKGQSLGFVAVMLQAAFSFIGTEVVAIAGAEVKNPLRSIPKAIRNVYIRLLLFYVGGVAIIGLLVPSTDERLNIADGTAAASPFVIAINNAGIKVLPSIINAVILTSAWSAGNSQLYVSSRALYGLALNGNAPKIFLKVTHYGLPWVALCTSASFALLAYMGIQSGSGKVFGWFANMCAVAGLSSWLGIAITYLRFYRGLLVRGIDRKRLPYRSPFQPFTAWYAAVGCAVVILFSGWSVFLKGHWRTDTFVTNYFPIAAFCVLYAGAKLWTRIPFMPYAEMDFKSGLQEVLDASYEEPKPRNWIERFWQWLKRRTMTQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MHP8</accession>
    <name>A0A4Q9MHP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_952946</name>
        <name evidence="4" type="ORF">BD311DRAFT_669140</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143457">
        <property type="protein sequence ID" value="TBU25682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145271">
        <property type="protein sequence ID" value="TBU52013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MHP8"/>
    <dbReference type="OMA" id="PNGVIHV"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF122">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597579" evidence="2">
        <location>
            <begin position="20"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="25"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="192"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU25682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="413" mass="42396" checksum="154E5D3C60747AC3" modified="2019-07-31" version="1">MKLFAASALLLASAPVALGQDFTLLNELFQALNSSGHTQLVSAAQKLNGTGSGQSILAQLSDRSPSVLFAPTDSACTSPRFLVSSDVDVLADVIAYHIVSGNFTGVSTTYPNTTVGFTLLSDPKVVQLEASGLHQVVAWATRSDGKIHVLNQVNDTTVTNTTTFGNITINSIDHVLNFPQPLSTTVVTDNTSLTIISTVLHNVSFPFFNASTNQTASTPLFNILESGLHGFTFFAPNNTAITQALSSLTSLESDQTAVEALFQNHIINGTTVYSPLLAGSNANRTSAAGEPLSFVLNATGHYVTSGNVTAQIIQPDVLLPNGVIHVIDRVLVNTESNAAAASSAASSASSAATHTSSATAPVGFSATATSSGSASSGSHTGNAARGTHAGQDSQHLLKVALVFGGVVAGLAMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MI11</accession>
    <name>A0A4Q9MI11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Guanine nucleotide-binding protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_276176</name>
        <name evidence="16" type="ORF">BD311DRAFT_667288</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Involved in the mating pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <dbReference type="EMBL" id="ML143444">
        <property type="protein sequence ID" value="TBU26527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145277">
        <property type="protein sequence ID" value="TBU51905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MI11"/>
    <dbReference type="STRING" id="114155.A0A4Q9MI11"/>
    <dbReference type="OMA" id="FMAIQAM"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000692">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0807">Transducer</keyword>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="151"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="201"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="270"/>
            <end position="273"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00072426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU26527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU51905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="40703" checksum="15F1D7FAC2CE6A78" modified="2019-07-31" version="1">MGNCVSTQDREAQLRSQEIDKQIEEDSRKLKKECKILLLGSGESGKSTIVKQMKIIHQNGYTPDERNAYRQTIYKNLLDSAHHIITAMRKLGMDCEDPANRARLEKILDYSVNPAPTFYFAEDMAKAIFDLWKDPIIPKIMDHSSEFYLMDSASYFFTEALRIGTPNYIPTETDVLRARATSRGITETRFSLGPLSIHMFDVGGQRSERKKWIHCFESVTSIIFCTALSEYDQVLLEDRNQKRMQESLILFESVINSRWFLRTSIILFLNKIDVFKSKLPKVPLERYFPEYTGGPDINKAAKYILWRFMQANRARLSVYPHLTQATDTSNIRLVFAAVKETILQNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MKN3</accession>
    <name>A0A4Q9MKN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_846972</name>
        <name evidence="7" type="ORF">BD311DRAFT_759377</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143426">
        <property type="protein sequence ID" value="TBU28005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MKN3"/>
    <dbReference type="STRING" id="114155.A0A4Q9MKN3"/>
    <dbReference type="OMA" id="VHITFVD"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU28005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU60806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20520" checksum="246E152ACF799773" modified="2019-07-31" version="1">MALPRSHYDPRRVCINPFPGISLGKHRRTIGIYLAGGLFALANWTFLDAAVLSAHAHPPYTEPQIPPPVHVTFVDWLPGICSLLGMIVINLIDKDRVQGHEDFGDARAVWRARLFLFIGFALMAGGLAGSVTVLVLKYILHHYTEQYTYYGYANVSQNVALMLSAIVLWISQSVSTEYEYTLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MVG1</accession>
    <name>A0A4Q9MVG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_944663</name>
        <name evidence="15" type="ORF">BD311DRAFT_715237</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MVG1"/>
    <dbReference type="STRING" id="114155.A0A4Q9MVG1"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051903">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="14">
        <location>
            <begin position="35"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="204"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU64163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="379" mass="40417" checksum="7B5C0B210D9C1F4C" modified="2019-07-31" version="1">MSETAGKPITCKAAVCWAAGEELKIEDVEVAPPRAHEVRIHILWTGICHTDEYTRSGKDPEGLFPVILGHEGGGIVESVGEGVTSVSVGDHVIPLYTAECRECKFCKSGKTNLCGSVRATQGQGLMPDKSVRFTVRGQPIHHFMGTSTFSQYTVVADVSVVAVNPKAPLDRVCLLGCGITTAWGAVVKQPGIKGSTVAVFGVGAIGLGLIATSALVGASRIIAVDTNPKKESWARKFGATEFVNPADLPEGKRIQDYLIEITDGGLDYTFDATGNVHVMRAALEACHKGWGVSTIIGVAAAGQEISTRPFQLVTGRTWRGSAFGGVKGRTELPGLVEDYLQGKVKVDEYVTHRRTLPEINAGFHDMHSGDCIRCVVDMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N9E5</accession>
    <name>A0A4Q9N9E5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_11496</name>
        <name evidence="8" type="ORF">BD311DRAFT_10029</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N9E5"/>
    <dbReference type="STRING" id="114155.A0A4Q9N9E5"/>
    <dbReference type="OrthoDB" id="1695362at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="62"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU35656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="357" mass="39897" checksum="2EBDB6677776511E" modified="2019-07-31" version="1">MISLARPHVIRRPVRISRMPISCSFPATSATTFTFYYSTTRASTMSSRPAAGIVQSRPTPQAPRPSATAIVVNSQNEVLLVHRNPKSSSFANAHVFPGGNYDKKQDEGQGLPFTAIREVFEESGLLLVHPSSSGLPIDAELDKAREAIHAQKRLLNDFLIEHDLKPNVEGLLPFTTWITPPIYPKRFRTQFYVTFLDETRSAGFSSGDKQERLPTPDGGQEVIEARFVHPTKALEEFYSERITLFPPQFYLLTTLSSLLEGPRNTPEQRERVRALSNGAFGQMVINPRVIRDKDAEAEGYKVITYEGDEANGGSPGRRHRCRLKFGQGGSATYITLERNFDIFTEIESHLFSAPAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBY1</accession>
    <name>A0A4Q9NBY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_944392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBY1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="578" mass="64022" checksum="42A39CDDFF26BC9C" modified="2019-07-31" version="1">MKRSLSVSAIERARRLSDAVRGAIAPVLAYRPRPQRTQDDSSLDYYGSKHKRVKSSESGLHRTLSLRHRNISKDDIRPFPGINASSSTLNLWVGGATIATEPESPQLQSRWSADTDVLEMRTSRGRKTERGAKTAKPTRPVKPDRPEGHDPLASMLRHGITGLAPSPALLVSEDRRQREAMRRSKESARPAAAAPSPGPSRHQPTVRRGVRDDDSEVGPPVPPKDYVMQKVFSPFAIAPPTGHTIHQSPRRNNNGHHRPGLTRDMSVKSAPDGTSGVTRVVPTPRRQATLDERVRHDRGGFGIDVSATTGSIQKQPQPTQSLRRTPSSADVTLRAPTRAHRQAEPRPQEDERNGQHGRPDENASQRGRGLSAGWCAAAFHPPSPLPDLLWKRRPSAMDVPRDVRPDDGDSIFHSRGSAVPDRSTRPTGRPTERARTGEARGMLIPTAPVAGSGMIAKVQGSLRVRDSPASRPVQMAATPPAQDRPLSYEGEVVIAPFMFDDDPPEPTKVYESRSEYERRLAEERYVERLSRTNPWKSEEYAYQQQQVAQAVAEPESVRPLCIRKHSSQTKENKYNSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NC84</accession>
    <name>A0A4Q9NC84_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_813625</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NC84"/>
    <dbReference type="STRING" id="114155.A0A4Q9NC84"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="9">
        <location>
            <begin position="379"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="787" mass="85064" checksum="3C61277947F2FA86" modified="2019-07-31" version="1">MLSAVAARKARLAQNQAQTPPQTAAVPPLPPGPTSQPPSDFRKKPSSHQKPPSKRKPSAPAGNATKKRKGQNRRSSPEPSARYFVQPDAFENQEDIIVVNDSDSETSVASQDTPSEGEASRIPPSRLNPRPASRKRAWSPSVPLQDSSDEEVEDADEILILDAINPPPDESVPVAPALLSTFRPVLDQNVFRLGPSDLSANKRTALLLSAGDTVALLGTYSITVLRGTVDLGGVSLNASTTSYPVFAPRSSPIPIIQCRPHKGSSSDPAFLSTLPNRVAAASKDYDAAIILQELHTGIEGLGRICRTFDGFFAPSRWHRGRVTFDLGLDTVYYLTQQTSDVVPLDIPPSWDAAVKAILPTSDQGTDATAEKKMVYIIKGAKNTGKSTFARLILNRLLSRFQRVAYLECDLGQSEFTPGGMVSLNVVEQPVFGPPFSHPSIPYAAHYIGATSPRATPSHYLESIHALVQLFNLEIQSAAAEELGSDDGRFNSSIPLVINTMGWTKGLGADLARKVQEIVEPSHIFSFDASVGEEWDTTGRVDTLLSPSELGGPHVQSVEPVQRPSTLTHYTAADQRNLSILSYFHAVLPNSPSTSLLTSPVAASWSSTLPLCAQPPYELDPRVAFDQLFLTGAGTEDVTPSEVHRALRCSVVGLISCQPGTLDSDARIDAEDDARPSPFYEQGVLPPSPHTSKCLGLALVRAISPSPSSRIHLLTPVPPHLLGSARVIVMGELQLPVWGMLDYRTLDDGGDIAGYDREKVPYLRWGKGEGAGGERRRVRRNLMRRAQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIM8</accession>
    <name>A0A4Q9NIM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADPH-dependent diflavin oxidoreductase 1</fullName>
            <ecNumber evidence="9">1.18.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">NADPH-dependent FMN and FAD-containing oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">TAH18</name>
        <name evidence="11" type="ORF">BD310DRAFT_883890</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 oxidized [2Fe-2S]-[protein] + NADPH = 2 reduced [2Fe-2S]-[protein] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67716"/>
            <dbReference type="Rhea" id="RHEA-COMP:17327"/>
            <dbReference type="Rhea" id="RHEA-COMP:17328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="9">Relocalizes to mitochondria after H(2)O(2) exposure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ML145164">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="term" value="F:flavin adenine dinucleotide binding"/>
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        <property type="term" value="F:NADPH-iron-sulfur [2Fe-2S] protein oxidoreductase activity"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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        <property type="entry name" value="Flavdoxin-like"/>
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        <property type="entry name" value="Flavodoxin/NO_synth"/>
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    </dbReference>
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        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
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        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
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        <property type="entry name" value="FPNCR"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0274">FAD</keyword>
    <keyword evidence="4 9" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 9" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0521">NADP</keyword>
    <keyword evidence="8 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="33"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
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        <location>
            <begin position="80"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>FMN</name>
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        <location>
            <position position="153"/>
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            <name>FMN</name>
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        <location>
            <begin position="393"/>
            <end position="396"/>
        </location>
        <ligand>
            <name>FAD</name>
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    <feature type="binding site" evidence="9">
        <location>
            <begin position="427"/>
            <end position="430"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
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        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
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        <location>
            <begin position="525"/>
            <end position="526"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
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            <begin position="534"/>
            <end position="538"/>
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            <name>NADP(+)</name>
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        </ligand>
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        <location>
            <position position="609"/>
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            <name>FAD</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
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        <source>
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        </source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
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        </source>
    </evidence>
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            <dbReference type="HAMAP-Rule" id="MF_03178"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="EMBL" id="TBU55699.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="610" mass="68894" checksum="7967F1CD2E49626C" modified="2019-07-31" version="1">MSSTPPSSSSRSSTPGCDGEAHHERTLTILYATETGTAQDVADRLARVCRCLHIHARVHSMDAYSPAELINEHLVIFVVATTGTGREPRAMTPLWQTLLRADLPEDLFEDLHFAVFGLGDTAYEKFCWPAKLLSRRLEALGGTELCARGEGDEQHHLGIEGALAPWIEQLSAVLLEAYPLPDGLERELFDSLPSPRVAITEADTDAQITRKDPLVADREYHTATLVVNSRLTAEDWYQDVRHFEFELAEDVEYDPGDVAIIHPEAMPQDVEAFLSCIGYANTADDPIEIRQTLLDQHLPDHIPTITTLREVFTRYVDINAIPRRSFFALLKHFAQDDMEREKLEEFLSEEGADDLYEYCQKPHRRIHEVLDEFRSIKIPREYIFDLFPPLRPRQFSIASSIRAHQRRIHLCIAIVQYRTMLKIPRRGVCTTWLANLKPGDKLQIGLQKGFITLPNDPAIPVICVGPGTGVAPMRAVIQERLHAGLNTGDDILYFGCRSEAKDHYYGAEWRALAAEGKLTYRVAFSRDGPEGKPRTYVQDLIREDAKRIWVLVGERGAWVYISGSSNKMPAAVRAAIAHTVQSEGGRTEEEAKEYVARMEREGRLIEECWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPD5</accession>
    <name>A0A4Q9NPD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B12 subunit family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_914482</name>
        <name evidence="13" type="ORF">BD311DRAFT_688708</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU64348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="14" id="KW-0830">Ubiquinone</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU31697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU64348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="7012" checksum="F50772A356EC61A9" modified="2019-07-31" version="1">MPPPDPQLYRDPWGKREAWRKHPVFSRRQMFARAFPGFGVALVAFTAYVIADNLLTKGKAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR24</accession>
    <name>A0A4Q9NR24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_886091</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="2"/>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR24"/>
    <dbReference type="STRING" id="114155.A0A4Q9NR24"/>
    <dbReference type="OMA" id="MAPSQCK"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049482">
        <property type="entry name" value="ANM3-like_C2H2_Zf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21137">
        <property type="entry name" value="ANM3_C2H2_Zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase 3-like C2H2 zinc finger" evidence="14">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase" evidence="13">
        <location>
            <begin position="265"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="372"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="519"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF21137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU54460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="597" mass="66760" checksum="E22AD296FEAE0B08" modified="2019-07-31" version="1">MALRFSATHITNQEESSDPEYSETHPGESSSEDEDEDLTWDDWVSDSLSKRPCKSLFENRTFDTVQEALAYDETTHGSSLKEITARLRLDPYKRIRLINWIRKEHPSSSEVANLTGSEPFFTEDEYLKPSIEDDPLLQIEPDDWSDSDEEAEQGTLEEPKDLDTAKRQIKALQRKLQQATQDLVYYHQFVSERLNLAGLADELQKGEGTSSASHVAVPLRDDDSHYFQSYAENDIHSVMINDKVRTASYAKFILSNPELFRDAVVMDVGCGTGILSLFAASAGAKRVFAIDASDIAEKAEKIVKANGLDNVITVIRGKVENIKLPEGFDKVDIIVSEWMGYALLYESMLDSVLHARDRFLKDGGVMAPSQTKMMFALCEASELFKERIGFWNDVYGFDLSEMGSHVYDDAVVDVVGPDTVVSQPVEVKDLYLGSITPKQLDFSSPFKLVSTSERRIKVHAFVLYFDTFFTNTGAPIPDDVEAYVIHEGDPILAEVWPLGGRPYQGRRMSTGGGLTGRPKVTSFSTGPASMPTHWKQTIFFLREPISVADGTVVEGMFKCKKSTDNSRELDVEIHFSVREPDADAGAGDVVVQIYKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NS06</accession>
    <name>A0A4Q9NS06_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_823273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NS06"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="328" mass="35587" checksum="5E6A7DBA50C58963" modified="2019-07-31" version="1">MSHTFATQSGRHIDAIGVHGAHGQSDSPVMLHVPYVERPHALPTSSTSSGFVHGAARQLSPTLDSASLRYSPYPSPLSSTSSRFSGSSQGGSSVDISPTFTRPPAGRAVPSVGETIKLPPIQPPNRRASEDHDSFQLPPISAMDKLRETQCDEPMAVLRRLQYTDDSGVDDLPRARRVMSAEHLAQRRHSLADHINTSSDTSFFASARTNGPPTPVSAAAALSPSFRLPQSKREHLPRSALEPPPSSFMHTTRRTPHDVSMSRSMPPSPYLGPSHSDYGDRPRLDERYMTERAFYGQERPPSPPPSASSASAESPSPSDSARSGWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSD6</accession>
    <name>A0A4Q9NSD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_920865</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSD6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NSD6"/>
    <dbReference type="OMA" id="LEGWMRF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043433770" description="RING-type E3 ubiquitin transferase" evidence="16">
        <location>
            <begin position="46"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="677"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="461"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU61497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="754" mass="83936" checksum="B5EE703F44AA80C1" modified="2019-07-31" version="1">MSTPANDPTRDLENGTDTPSRQQRSSVPSLLFLSFILFMLMNGHGDELANTRDLYVNGLQSLNWQLGNFSAWLNGTESNFTLPVEDPNTTPLVAAFLPFGLELDPKQGSYYSNLTGFWHGDLQLHNLTSLNATEKTSPWRHLAEQWMLTTNLSEIPERLGSWNWTRSNKVTLNVGDKLVPYKQSEEGETKSIAIIHGKVDLAEPKSDDDLRLDFEGVHVLSTGTVYALAVSTGHGIDLRNLPALVPETYRNDSARAVEAEIRIRASKLKEKIDAGSFEQDTSSNEDESPKTKCLFRFFGQLDVTTVPKELMDELENEIDEPTGITTVRAPELSLGGVLLSQDCGILYEIKHTVGVQTQKLYRKITTYAGLSTLVNFLLLVLFRRQAARSSSAAGLSRVSRYTFLIQSLLDAISFVGHVTVAILADGRPSMSVLAPAGLACLLFIYEAQFAVLIGQIQAPEDAPTPRPAAPAPTTAPPPQPQPQVDGSTPTSSGPADQPAPTGVPPVVPTPPPALPERPSFFRFLLHHIRTDPAARLWMMISLCLIVVFRIVIMLSLPLFFIGSLYSCMWLMQIYRSTRRARSSGLSAEYLIGSTLGRLFFVCYFLGCPKNIFDVEPRGWIWFVALIMLLQVFVVFLQEHVDPCFFLPTRVSRVQTYNYHPIIPLPDPEAPEQTLGDCAICMEAILVDPSLRRRSKSSDAKERPAIGLPFLRKVTTARKTYSLAPCHHLFHTECLERWLTYKNICPQCRRPLPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUU0</accession>
    <name>A0A4Q9NUU0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6699 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_823178</name>
        <name evidence="2" type="ORF">BD311DRAFT_669625</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143461">
        <property type="protein sequence ID" value="TBU25430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUU0"/>
    <dbReference type="OrthoDB" id="3241567at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046522">
        <property type="entry name" value="DUF6699"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20415">
        <property type="entry name" value="DUF6699"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6699" evidence="1">
        <location>
            <begin position="16"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="18024" checksum="013D37FB47A7F6F6" modified="2019-07-31" version="1">MAKRITAREVVVRNIRDKLKEVATHPPTSRVTIAYNTAVPELLNHWGPIVVDKGEGGTVTVGDILDAVFDFFQVPLTYAEGYELPREHSAEFSRMSLAFHKRCRDYPAIPEKTYEGGMLRVDALTDRYKWWGMWVQWNPDGSWYLNLGTDLKRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZ90</accession>
    <name>A0A4Q9NZ90_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase I-specific transcription initiation factor RRN3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_916912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZ90"/>
    <dbReference type="STRING" id="114155.A0A4Q9NZ90"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="312"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="717"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="789" mass="87832" checksum="3C8F50040004EE7F" modified="2019-07-31" version="1">MDPHSRFSHFNSRQTKAGPIASGSRHMEQPKTRISLDNLSTKKGPKTPSTPKKSSSISSPSTLYTERPTVTNSRIKQDEQYRKDMHLAFVNNALQMKAMGISDAFDELVDQFNPRKIIQVIPEAPSPAPQLRLWILALSHVVSRLERVHSGLVEAIVNMPWTTMDTSFVKSYTNFIGMLVSARPEYLSLVLGKISQGLTYQSGLQALDSGLPESSARPLTRRIVYDRIHYLLRHLISLVPTCPSTLQPLLARNFPHKRQNQIAQVTYIRNLLRVTEYCPEIADRILALVIDRAIQVDVEIQVELEELEEALESQGQPEVFDLDPFDTVLGQEGDESDSEGEESDDDGDNLSDLSSDAGGDPDDDSDQEDVATDFTHIQGMVNKLDCILKVIFDHFNQTYASSDPVLLPPPGTPSSRSASPSMSTSTIEISRSLLPMTVEEGKALRRAQFHTLLAIFDRTILRTFKSRYTQFVVFWYSSLDPEFADLFQGMLVSKALLEEDQPPVTRAAAASYIASFVSRAQFVDREGARRVIQVLCNFLRARLDVFDAMAAAVRQGLVGTSTMNVAQHSVFYAVAQAVFLIFCFRWRDLLEDQEEVDEFAPQQGPPKKWMPELDVMQRVVTSELNPLKVCSPNVVMQFARVAHATGFVYCYSIMEANRRSDYAPNAEGGRPLPKPKAIVFEQSVTSELNAFFPFDPYKLPRSGSYIQGVYREWSSVAIDDGDEEEEDDEDDEGGEGDDEDVASQPIGIMINGARAGSQPADEADGLGESFGGMSISPARPEHTPQVLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZQ3</accession>
    <name>A0A4Q9NZQ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_947046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZQ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7433" checksum="6B80553EEBF148B4" modified="2019-07-31" version="1">MSLGTGPAVCVIIEILGPRQSTEDITPTSGRIAWDTVSQLRLKALGTLLMELVNGEIDFANCALTSRAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P098</accession>
    <name>A0A4Q9P098_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_815710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P098"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="289" mass="31054" checksum="83D06A2FF9E8473F" modified="2019-07-31" version="1">MDPVTGSSSGLGLDITRHVLSKGDIAVATLRKPEVLDELIAEYPKERLLVLKVDVTVHQDILDAFKKTKEVFGRIDVVVSNAGTGLLSEVEGTPDDVARALFDVNFWGSVHVLQEAVRFLRDENAPGKGGRVFQITSGMELVGFPGCGFYSATKHAISGLAQSLAKEVDPAWNIKLTIIALGAFGTNAVNAMDKLPVHPAYDNPDLAVAKWRKAVIRSQSGDFDPALTIKGDAAKAAEAIYRLSEEAAPPLRIPLGCVDLARGATKDLSDEVEKWASCSVGLDKDEYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P0T2</accession>
    <name>A0A4Q9P0T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_959397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P0T2"/>
    <dbReference type="STRING" id="114155.A0A4Q9P0T2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="60810" checksum="FEE7BAB4B3C69B33" modified="2019-07-31" version="1">MSLGPTLALANQDVLYTVFEHFVASETAWYDFDIMTRRVKSVDDPEEIVRRRTLASCARVCRAFLFPAMTILWRDLDSLEPLNALVQHRASQVTESMCLPWLPTYAQYSRWVRAVRNSWTAPSPLPSCASADVGQPPLSLSRLVRLRWVQKVPGTMDLLQLLSPALHSLHIVFRGAPAWDHHRRCEYQTFVETLLLRAAESAPCLTYLRITRGNGILEDWLRPVCRFSRVQVLDILEPAYDAVTTSDLLPRLGAMKSLRSLKLRLPAAVGHAFDNGTQSFTALRVLDLGSRFASLHDAIKMLRLVSSPYLESVHVDGCECETGLLSAGLHDLCTVLDARFAPTLRTISLSITPIGSPIAFEQPLVKYLKPLLRIRHLADVRLHLASKNVSVVVSVSDFVTIAESWPHLEHLELSYVPSGKAPSLRALIPLARLCPFLTHVQLPRIDARDVEMASIPPHRSLMSFSISDGGWDSLIPDPQGVAYFLRKLFPNAELGRPHLASEQWCRTAKEFRDSRARKDRGNDLVYCWTPLVVLEVGHSPCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P309</accession>
    <name>A0A4Q9P309_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_931040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P309"/>
    <dbReference type="OMA" id="WEPTYEL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011935">
        <property type="entry name" value="CHP02231"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037291">
        <property type="entry name" value="DUF4139"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025554">
        <property type="entry name" value="DUF4140"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02231">
        <property type="entry name" value="mucoidy inhibitor MuiA family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31005:SF8">
        <property type="entry name" value="DUF4139 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13598">
        <property type="entry name" value="DUF4139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13600">
        <property type="entry name" value="DUF4140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="704" mass="75022" checksum="97D0C60B3C3DCC64" modified="2019-07-31" version="1">MTSSTISLDASEHPVKSVTIFQSSTAELKRTFTIDLKAGSNVVKISNISSHVDRESPRIHGLGTDARVVDISCNTTLANAPSHKSSKNAIEIKKLTAKRKLLEGERTVRQRESELLDDGARSLVSDKETGLDVFMETWVSRKRSAMKAIVDLDDQIEALDQEIWQLNNIHKGETAGVVTATVLAKHERKVEVQLTYLVTGVTWQPYYDLHASTSDGKPSSDVTLHYCANIIQTTGEDWSNTSLTLSTANSHALRSLSVPRVDPLRFTFAGGRLLGSSGNNINTNVARGPFGQPVGGGGGLFGQPQQQQQSAFGQASLFGQGQQQLPQPVQTGFGAFGQAAVQPQSQGTSLTSFLAQKPAQPQPGSFLGQQPAQAVSTGLFGRVSSPAQGGLWGSAPANPQPVIVVPPSQANTAPGPFSVRPASAAPANADPEEEFEHVGGTPGSEEDEVGQGAVLDRSPLSLAYRVEGKVSLASDGIAHKVSIAVLDFSAVLKYVCVPRKTNAAFIEGRIKNTSEFELLAGPVSVFMDDSFVTKTLLGLIGVSESFVCVLGIDTSLKVAYNTKARTVYEPRRSFAEPSKTLTRTVVTTISNGHPFDIADLVVRDAVPIGSDEANIAVTLRKPEGLAQAKDGEDVAVKLSGETKGATVRWTKVESGAGGERDGLYEWLCGVKAGKKVQLEAEWDVKAPSSVRLEEQPNIRFGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7C1</accession>
    <name>A0A4Q9P7C1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="7">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_809771</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 10">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tannase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7C1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033916" description="Carboxylic ester hydrolase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="538" mass="58642" checksum="2F68F215CFEBE722" modified="2019-07-31" version="1">MNLLSLLALLGFAAAVVAVRDSPSACSAFKPTNITNVALTNLPTYFSANASVNISNEYSSIDVSNLPAFCRVELTITTNTTAGSFALTEVWLPDDWNGRVLTLGNGGLAGGVTVAELGYVAVPQGFAGISTNTGHDGDVDDGSWAGPHNDNAIVDWGWRAMHLSVVAGKEVVQQYYSTPANKSYYLGCSNASPSLKEVQEFPEDFDGVIVGSPANWQTHLRGWSIHMNLNTQPSTSPHFMTEDIWDNVLAPEVLRQCDSLDGLVDGIISDPRDCAFRPETLTCSPGQNKSTCLTPDQISALHRIYAPYYEANQTFVFGGYFPGGETKFYHGLVGKKQSKPTKAYFQFMVTNNTDWTIHDYNATLLQLTDELDVGQSNAINPNIIGFVGSQHNGKLIQYVGWADQLISPNNSIYYYETVHEWTRANTNLDIDDFYRLFTVPGMNHCHGGFAANAFGGVQQASNNNPPLSLDPQHNILAAIVKWVEDGIAPDNFTAVNYNSNDVANGVGFTRPLCRYPSNLRYKSGDPNSASSFECVFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7Z9</accession>
    <name>A0A4Q9P7Z9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome oxidase assembly</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_873946</name>
        <name evidence="13" type="ORF">BD311DRAFT_655246</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7Z9"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7Z9"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU32178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU61344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="447" mass="48931" checksum="9DDE0905ED172F85" modified="2019-07-31" version="1">MLSAFRKNGLWSPSRNIAFRAGTAPRRAFDPRFFSSNAADVPVSELPVLSPPSVGGWLLGSAVLVFAVIVVGGVTRLTESGLSITEWRPITGVLPPLSRAEWEKEFDKYKATPEFKLLNHSITLEEFKDIFYMEWGHRVLGRLIGIGFVVPFAYFALRKQLTAALPRNLFGMALLIGAQGALGWYMVKSGLEDSLLETPGAVPRVSQYRLAAHLGTAFVLYAGMFYTGLATIMDWRFAKKGLWGGLQDGAAQWKDILANPHVRKFARNVKGLTGLVFLTALSGAFVAGLDAGLLYNEFPLMGGRLAPPANELFDPAYAKSADKSDIWWRNIFENPTTVQFDHRCLAITTYVATAAVYASTFNPVIRAALPPLTKRLATGAFAMANVQVLLGISTLLYLVPIPLAAMHQAGSVMLLTTVLHLLISLRRPGAAAQAWRQALRNTKRTTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9G6</accession>
    <name>A0A4Q9P9G6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1007573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145345">
        <property type="protein sequence ID" value="TBU51290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9G6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="299" mass="31546" checksum="FDA57F097A46B4AD" modified="2019-07-31" version="1">MPRGGSKVGTGGGRGRGRGRGRGRGRGRGRGRGRGGGRGGGRGTSTSAPASVTSEDPSPHISFPSQQDQEQLTNSPLPTQTNGPRTGHGCVHAFGASTPTPPSSEDPPTGDSLGSAFATTDADRADNERRVAESQAKADEATKRKAATTAQQEREKAGSCRLAALEDVRYREEQVEEAYLARPTASGYHLPCGGALSASTKTADAPMEVDDRAIGHPSFRGASAETYEDQDGTQSSQVRRKVRRREEVLDKISRSRPLNVEGAHGPSVKTPAKRRTEDVEGGKRPPKKPAVSAFNDEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAF8</accession>
    <name>A0A4Q9PAF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_974686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAF8"/>
    <dbReference type="OMA" id="PQWTSTC"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9094" checksum="9F3C0389DA45C557" modified="2019-07-31" version="1">MSSNDGTVALNNYLQNKGRAAALHWEDTFTGPRHDGQWTSYCKINGEVIATGTGTQKNAARDAAAREALPILMAQDATEAETVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAJ4</accession>
    <name>A0A4Q9PAJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_837876</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAJ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAJ4"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000041">
        <property type="entry name" value="Chaperone protein DNAj, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU66218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="399" mass="44191" checksum="728EC43ED7509F61" modified="2019-07-31" version="1">MVKETKYYDLLEVSPDASEADLKKAYRKKALRLHPDKGGDPELFKEVTHAYEILSDPQKRSVYDARGEAGLTDAGGMGGMDPQDLFSQLFGGGAFFGGGGPTRSQGPRKTKDLVHRVHVTLEDLYKGKTTKLALTRNVICAKCSGKGGKDGAVRQCNSCSGRGIKVTLRQMGPMIQQLQQPCDECSGTGEIINHKDKCKTCNGRKVVSEKKMLEVHIDKGMRGGQTITFRGESDQAPGVTPGDVIIVIEEKPHERFKRQENDLFYEQEVDLLTALGGGQFAIRHLDDRALIVNIAPGEVLKHDELKVIRGQGMPSQRHHEPGDLFVRISVKFPDSINPEVIPLLEQALPPREPLEKFPPSIHLEEVELDEVDARQRERAAGEDAMDEDDEHPRVQCANQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBW5</accession>
    <name>A0A4Q9PBW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ras-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_862271</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145261">
        <property type="protein sequence ID" value="TBU52219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBW5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBW5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001918">
        <property type="entry name" value="Small GTP-binding protein Rab18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="24611" checksum="ACCDD9468B4B4577" modified="2019-07-31" version="1">MSQSQDKATAPINVKLLLIGNSSVGKSSLLLRFSDEQWLPEDESSATIGVDFRVHKMDVKGKKVKLSIWDTAGQERFRTITSSYYRGAQGIILVYDVANRESFDALPKWFSELETYVSSSVVKIIVGNKVDKEYSRQVSASEGQAFAARMDALFVEASAKTAVGVQEAFRDVVERIMDTPELWQTSAARKGGSGKPGGASGGRGEDMPGSIDLRQEPDEAEGGGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCD3</accession>
    <name>A0A4Q9PCD3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_832623</name>
        <name evidence="2" type="ORF">BD310DRAFT_834467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145329">
        <property type="protein sequence ID" value="TBU51402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCD3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCD3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8689" checksum="5A48963E05F84343" modified="2019-07-31" version="1" fragment="single">MYHCAQNSKRQRKPQKVPDASKHRDKEAMDGFPCQGWLSVTVTDGSDSLFITLGHRLDHIPYVPIDLPDSVVALVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCR5</accession>
    <name>A0A4Q9PCR5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_861971</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145252">
        <property type="protein sequence ID" value="TBU52408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCR5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCR5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="11"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="167" mass="18578" checksum="11210728D5BF51A0" modified="2019-07-31" version="1">MPDWDTHIRRGHPVLFGTFIFFSIIELAISGWLTHRYNSRHDFLSTSVRNDVAFLVFASVWTLVFSIVYLALFLRAPGFGIATSVLSHLVFLFVTWVFWLSGAAALTAALGGRLNCSHHFVYCGQLNALEAFAWIIWVISTFALVVVFLRAITASRRGDGAKGPLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD06</accession>
    <name>A0A4Q9PD06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">3-dehydrosphinganine reductase</fullName>
            <ecNumber evidence="9">1.1.1.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_939571</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>sphinganine + NADP(+) = 3-oxosphinganine + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22640"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57817"/>
            <dbReference type="ChEBI" id="CHEBI:58299"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.102"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:22642"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="1.1.1.102" evidence="9"/>
    <dbReference type="EMBL" id="ML145239">
        <property type="protein sequence ID" value="TBU52720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD06"/>
    <dbReference type="STRING" id="114155.A0A4Q9PD06"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047560">
        <property type="term" value="F:3-dehydrosphinganine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006666">
        <property type="term" value="P:3-keto-sphinganine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08939">
        <property type="entry name" value="KDSR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045022">
        <property type="entry name" value="KDSR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43550:SF3">
        <property type="entry name" value="3-KETODIHYDROSPHINGOSINE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU52720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="337" mass="36213" checksum="96CF110FFC230BEC" modified="2019-07-31" version="1">MVVSPPSQAAAAVSILVIIVTSALYNMLFSRKWDPRGKHCLITGGSRGTGLALAILLAKRGAHVSIVARDKPRLDKGLEGLERVRQDPKQIFRAYSFAVDSETGSAAALKAAGEPHGGRCPEALFLCAGASRPGFFIDQTEESFMGGIQMTLGAQAFTALATTKEMVRQGVKGKIVFVSSILGLMSFVGYTTYAPGKFAIRGLAETLRSELKMYGIDVHVAFPATILSPGLDEENEVKPKVTLKIEETDSGSPPEDIAAGILRGVEKGSFHITMDFFGDIFRATAAGASPRHNPVLDILYGLIGYIALPFWRKSVDAQVIGHAVEHREYCHTKGYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDA7</accession>
    <name>A0A4Q9PDA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_831471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145237">
        <property type="protein sequence ID" value="TBU52789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDA7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028018">
        <property type="entry name" value="DUF4646"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15496">
        <property type="entry name" value="DUF4646"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="337" mass="36619" checksum="8709DBFA7EF58D4E" modified="2019-07-31" version="1">MSYPKSAGYADTNRDYESPAGAPPAYNNPVYNNNPFLDEHRSPDPYPPRQQPSPYTNQPPQFPTYSSQSSASSPPEPLFAYTSITKQTPPPLPSHPSAFPPFETFTVYALGYRLADGFPTDLPLAHEQPHPFSSHVVVKDDWARFLLDVNGIARTSSEERLRENFPAEPSRNANPMLMPARGGIVRGLLGAAIEGASSRMGGGSGAKAAQEPISRLLADWNRNYWNRRQIEVSLVLKDVSDSGLSAMPGRGGLLGGLGGGGRRQARKEKRQERSAFKQDIIADVHSMFSSSQASTYRASADQARYGSKPGWCLVFRYTGPAGVGFAGGNESGWATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDB1</accession>
    <name>A0A4Q9PDB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superoxide dismutase</fullName>
            <ecNumber evidence="8">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_942527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="8"/>
    <dbReference type="EMBL" id="ML145357">
        <property type="protein sequence ID" value="TBU51227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDB1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDB1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
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        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF6">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [MN], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU51227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="25086" checksum="A60287AF2DCBABDB" modified="2019-07-31" version="1">MSILTTIARSAVRAPRPIARVPAASLSLAARGVHTLPQLDYPYNALEPHISGQIMELHHKKHHQTYVNGLNAAEEAYAKTDSPKERIKLQSALKFNGGGHINHSLFWKNLAPAGQGGGELSAGPLKEKIEADFGSVDAFKKKLNTVTAAVQGSGWGWLGYNPETKKLEIVTTPNQDPLLSHVPIIGIDIWEHAFYLQYQNVKADYLTAIWNVIDFKEAERRFLEASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDW4</accession>
    <name>A0A4Q9PDW4_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_834871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU51242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDW4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8882" checksum="43E0CEC16A979A49" modified="2019-07-31" version="1">MARTCSTRRFYMGENAVIFGQAAVVGQMAFPFRPFASNIPHCASLAHNRKPVWYGTNGRRCLRSRTLLSRNSGMGQLSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG88</accession>
    <name>A0A4Q9PG88_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_832839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="24230" checksum="40BBFD1995A53A4A" modified="2019-07-31" version="1">MPPNNRLPNSSRPSPSNPPTMQYLALPVEVIEGVIDRCSDHTKTLLAFALTCRDLHPRSILVLFTEVRPQSRDRLFDLCDVLKAKPERQPFVQSLSIHWETFAPYPLLSILPALCHITFSGYHESIVCHPSTVLCCRRFGCGIRSLTIKNAGFSTCTAFLHFLAAFPSIKHLTCEWLHIRQKGEASPLVQKSLSRQLRLRTLNVSVVIACLRIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PID4</accession>
    <name>A0A4Q9PID4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU53881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PID4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17427" checksum="987C9585AD1CEDF8" modified="2019-07-31" version="1">MYEAATTLRVPLGARYVSAAICACASHAKSAVACSQDQPKSVAEALGRLASVWLAFVLWPFYCQAMLPAKPSGEDSDSGDTTPTGRSEDLSRNTVAYRRWAVLRDELYQRDRYRCFMSGAVLDRTPEEALLGVFTTALLVTHIIGVPARARLRHYDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIE6</accession>
    <name>A0A4Q9PIE6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIE6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19361" checksum="175C6921F6F67CC0" modified="2019-07-31" version="1">MAGAYEPQNALLLNPGSHAAFIHFKWCLLPTDTTNCYEIQTHQSNFLGAIPVQDRVTFQDYSLETPAPDSADAERAARHRGVKRRRAQAGIDLPDPELLRVHAALAILLHSSGAAGIFDTMIRWRSDRNHHGVPEASGRAFWESVVMYEGPEICLSAELQNAAEAIGRLSTSTDPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ08</accession>
    <name>A0A4Q9PJ08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_980651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145198">
        <property type="protein sequence ID" value="TBU54061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ08"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="304" mass="34789" checksum="D9427FDF0E8C13C3" modified="2019-07-31" version="1">MVTFFDLPLEIILMIKTYLDPWDLRTVVCLYLADPRCAVLHDWETDPEAFWKTICWKNGLGRLPLDGGSEDGVWQDIALQCIERDGFCKHPHCGDAMLEYNRERMRESADCIEAFSAVHVTEDYDADVSFAPNPVLFYIDFRKSDECRDGKGQPIEDDAYLRWDNSSGSEKPNAGDARNRAYLGDHPITARSFATATPVSNILLLNMIGWRRPKNETLKLQRPVTVYDLLGLLHEDSLDYDLTVRDVSNHVGGHLECFRRMGWGVYDTFENLKTTREVLSVCPINSVEIVERTESGLKVRFCLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJB7</accession>
    <name>A0A4Q9PJB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_828572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="12242" checksum="EE685333E621C262" modified="2019-07-31" version="1">MDPRGPEAEPDELHNRWGALFKDEEEDEDYAPSECSSDRLSDASDWDPIEAAPETPILPIYRHNTRVMCERLAFSISRTRTSVVDRVKSILAVMDSVDMNLPMHLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJT2</accession>
    <name>A0A4Q9PJT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_77738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJT2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16060" checksum="CD2ADE4235A59B79" modified="2019-07-31" version="1">MFHPEMLHINVLRLPSSSNILTSRPSYRAVTACYAQHGHTPMSIAAFAVEGRDMLYSTPPRDHRTSDWLRLCLVPRYGRRVDETYVNAPGHTSVQDGGRGIRDRGVNRRAGGVGRMEAEGAEAAGQDNAGNRDSEEGLSPRQGDGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJV3</accession>
    <name>A0A4Q9PJV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_828155</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJV3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJV3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="314" mass="35644" checksum="447CF3D54197ABED" modified="2019-07-31" version="1">MAIPHTILAQFVAQAGDLTLYQIHKTSYPVSVITCYVLEAIATLPDEMRYVWPSDWSLMKMIYFFNKYSPFVDIVLLVQVDITSHDADACALQFQLLTYWLIVGVLCSEFILIVRTYALWGGDRHILYFNIYAAALMTPHAFYVAYDMLRINLKSFGDDAQMVRILGCMPAINDFGVWPAFVYMICAELMVVLSTLLKRYLDHASFADGSSRSSILLTTLYRDGTWFWAVVLVFSVVNLLMMFLAPRELSFLLQESLRTVHSALCTRVLLNLRKAAASTSYLGVGEFTVNTMALESLPMFAPLGEEEFEMEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK21</accession>
    <name>A0A4Q9PK21_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_980318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK21"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="305" mass="30425" checksum="65D7B7D7F25C57EC" modified="2019-07-31" version="1">MRLLCYVLAGVLVVGGNAAAIDKKAEAPTFSVSNVETPTLSISVSETPTLSVSIVEVPTVSVSNVEVPTVSISTVEVSTVDASSSASSFEPSSIRLSTVTTSEFPTSIVSASSHPSSTSIGISSTFTIPTSIGISSSFSFPTSIATRSSFSVPTSIESATFSCAYPTVTVTVYHPSSHFTTVTGTHISSRFTTVTGTFVSSAFGSSAPVVTGSATLSAVSSAATSAVGSSAPSAVGSSGATYPSGTQVISILFPSGTGETSTLVPSGTEVTSVLFPTETVVTSTLFPSGTVVTASTPPIASSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL61</accession>
    <name>A0A4Q9PL61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_857767</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145179">
        <property type="protein sequence ID" value="TBU54923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PL61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="634"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="708"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="788"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="880"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="972"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="1035"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="101"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="510"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1167"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1205"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1296"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1360"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1449"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1644"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="580"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="614"/>
            <end position="629"/>
        </location>
    </feature>
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        <location>
            <begin position="1211"/>
            <end position="1227"/>
        </location>
    </feature>
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        <location>
            <begin position="1321"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1449"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1658"/>
            <end position="1674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1714" mass="188615" checksum="773BC4C58AF90601" modified="2019-07-31" version="1">MAAFTVKATYRSETRKFSLPDSTFPTYDQLYSQLYRVFPISHSFYLSKLLFTPSPTSNARILIGKEVHSPEEYDRHVAPYRGGSWHGALLRFSVFDETPHKSSTVSPSDTLHDPFPSTPSSHSVASATTASTGASSPTVVGPAADSRLHLRGRQELVDRIRGHMNNRLSLHTMPPTPPASSRPTSMAESSSRPTSLASEPDGWRPLPIRPPSRGESAASTASVRTARPSLFDLLANAPSTQSVPRAVGTQPGADSDIVDLSSDNETISRHRDIRSRVDSTWKNDRPVSDALVLDDRSPSPRRPSIDDLSLPPRPHTFVAPPPPILFSRSSMFSLRAERGIAQTDGHVHKPAPTPRCAVTPPITLRTEAAQFAAQSAQPPQSESGERAKESRRRGRLTRMFMDETSPLLPKSKDEPCCSVSEAKAEVKVLMEKFKNDYERVMVKAFGEGWDRDNKASPKMEEAPLPRLPSPPTHLPVMPDLVNPRKAPRLNYYPPPLPVLPRRSLYSPPPLPPPPPPFVHSRPSLSSPSLPTLLPSSSSSWQRALPPPPPPCIIPSLPPPPPPFIRATPTVHQVSPKAEQSSMSPSSTISTPPLPPPPPNWIPSVAFNPTQDASQRNDVRPEIGREGRDNEETVHKNVRCDFCGRRDIRGIRYKCLQCPDFDWCSTCMASPEAWEAHAATHPFFPIHRKEDFLHFCYVKDRRDRRQLAHNGITCDGCQEKNIRGVRHKCLQCQDYDLCDKCVSSPKTRQGHDVTHVFFPIETPGDKDAYNKARKEASQPANAALSPATHVRVHCDGCEQYPIVGVRHKCLDCDDFDFCTSCISDPTKREEHDPSHSFFPMNKPSDYSKFDRIRANHRRTTVEPLRNDSGSAHVQTGGRLLHKNVFCDVCTVEIVGVRHKCLDCPDYDMCDECISTPHLREQHHAQHQFFAIEKPGEVVVHTVFSGDGEREPPRPAPVTPRVNIPRSEDVEPVVHNAMCDMCDSRIRGDRFKCLNCPDYDVCQSCYKITPEQHPDHGFVKISEPATLMIRNSANDPIHYASCNVCGSQIRGVRYKCVHESCDDFDLCQNCEAHPISVHPVHHPLLKLKTPGAVIPLVLRTQNVPPMPMNPSSPIRTPSPYGVDYAETPVPREPKVIDMESSFTNAPAHPPALPLPEFTPDLEVPVLPQVTPPTVENPSPRPYRRSLNPFSRFEHPSPESIMFASFPRHVSPMRPTPPSPERLVSPPPLSPISDVDFAPPRSPSPPRLVPVRSWEDMFGRAVPVVEIASVMPQFAQLVNLDDSIRATSPEPMPFLDERAQASADSEPSATAEHNEAEGTLEGISTPSDVTTSSASSKSVPKLGLVNSEWRELWPEMTSMFKHLLPPSPAEPSSTADPSPGNGFAISNAITNEPRSLEELNGPVVEESPLVGEPLLCRPLMPERSENRFTARRSLSDLINSMSPTVVAIPRVPSPESPISSPPSPVQDQVSLPPPTVPTSPVVAPIVSPFWDAIARLNPPLLAAFVSDSNIPVGQVFPPGAEFVKSWRMRNDGAVDWPETTELVFVAGDRMAPYTGAPTKFKIGTVKAGEEVELVSGEMKAPEVPGKYVSSWRLSDGNGNLFGQSVWVDITVAEMNEPSSDESLAASSVIMPRTAGQTVSARSSIEHQFSTSSMTVPSAPPSEIDSSVSLLDVSSSSSSDDEDYAVYEDSRSQFVPSPAADAQDVEYVMLFDSSSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLN2</accession>
    <name>A0A4Q9PLN2_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Conidiation protein 6-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_908565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLN2"/>
    <dbReference type="OMA" id="HNDRTSA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16332" checksum="3C40C0FFBC5732F7" modified="2019-07-31" version="1">MSGHDVSQLRLLAEKRVAAGLKAAINNPNVSEEARERAQERLEHMGASTETDNSGRYATGTVDSSGHETNRVLGGYKATLHNPRASDEAKQHAREILEADGYTVEPGPGITQDEHQTRVLAGYKAALHNPRVSEEAKEHAREYLAAHDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLP6</accession>
    <name>A0A4Q9PLP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_708677</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLP6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="180" mass="19863" checksum="0C17D7DEDA7E14C8" modified="2019-07-31" version="1">MVLWYCTLPSHNGAVTSVDTGTYLRTKSYREANQCASDGSTIFFDLGLWRPGRPACRLPGGGVSIPELNPHCSRHERARKGSHDGIPACGVTTSSLSKAYQHRTKSGVHVSGYYLNLPPGPSRASRNTLGVSRVVNRVFTRTTVNFIRFADTPWQDPMQPCHFITARSPHCCYIIAQRGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM67</accession>
    <name>A0A4Q9PM67_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_960926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM67"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="33091" checksum="BB896B638057DA24" modified="2019-07-31" version="1">MSSKRGRKRNDNLPPNRARDVQRAFRARRAAHLEALENRVAELEEENNTLRAALSLPPANRPPLGKGPTGKDKPKASGSKSATPSGLLSSLASGGPMPPLSRTESPLSTGSASGHSMSPDPMSSASGLSAPSQTSPPPLDPAGWSDNIFGDKDSDQSLSSNFSLPSTSSHASHNNPFSQIPRSVPNDIFPSAQGFTSSDEKSFGYLPSEGRRSYNYSHPLMSGHPSAQSTLPPSLSSSAGDTNDLAPFLQRRAITEPDGFRTLLNQMQASQNGLQTPAPRMSQSTLLNVVDAPLSEYDLPGGAERRYPRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMC9</accession>
    <name>A0A4Q9PMC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_933993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMC9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="177" mass="18943" checksum="AB054779F5D40E5A" modified="2019-07-31" version="1">MSSPTNQDKLTDANVSDELTDKPTAGTPASEPGVVEPGRNHQPSRDHPTAGMGAPSTPRPCPSPPIDEDDVTVDDIDNILGVAIGFFDLPRPLDDAAHARLHVMIATLPDRELRAAFIALVDSLPEVPQPVIRMLAPASGAETTPWGFGTQCSGKWCSRCWVGDRSANRRRAANTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMT3</accession>
    <name>A0A4Q9PMT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_884089</name>
        <name evidence="2" type="ORF">BD311DRAFT_714505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMT3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMT3"/>
    <dbReference type="OMA" id="PYKGVAN"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF9">
        <property type="entry name" value="BLR5716 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="21"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="135"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU32641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="256" mass="29710" checksum="F79AD9A4B9259415" modified="2019-07-31" version="1">MSFIKFPFTQLPHIESSPKRVRVFFGGEYIVDTTDALLVWLKPNYPYYFFKTKDVPEKYLVDAFQSQKHHIYDIVVGNRRAEAAATVYHDDELDGLIQIEFSEMDAWFEEDEQIYVHPKDPYKRVDVLHSSRHLRVEVNGVEVANTTRPRLLFETSLPIRYYIPTPDCKLELLTPSQTTTQCPYKGVASYYSVQLPTGDVHEDIVWYYRTPQLECAEIKGCVAFYNEKVDIYLDGVLQPRPESPWASKRASAVVPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMT8</accession>
    <name>A0A4Q9PMT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_933359</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMT8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMT8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="259" mass="27210" checksum="3474845CE9591E24" modified="2019-07-31" version="1">MSLTPGSPPRTPHTPPYTPTTPHTPLSAPHTPRTPSRHAAVPRPPVSPLHRPASLKNVQGGPSSVAATRRGSGHGLPGSAPGSLVGLGLDTGVRPSGVGAAGAGAVPGTPQKARARDLLRKHYGLGLGPPPPLGGAKSSQDPMDFDSPVFDARAYYEQLITTSSLPTLLKTENDLLTEIRQLDSERQSLVYNHHHELIAASDTIAAMKSRAENLDADLDLLRAAFSEISRLSAEIAVEHQSRTERRSSQPTTSSNSASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNS2</accession>
    <name>A0A4Q9PNS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_855851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="350" mass="40097" checksum="6EED9C37F34FCE4B" modified="2019-07-31" version="1">MKSEKNGFVHTVVEAHGRHHHLKIRPDDVWIAILSQLSFYVNKHADELREYFVAHEKKKELWVYAVGTRYTVDFGRLARQMSDQIHQHVVDKTLVEWILPDFTTSTTNDTTICSILLMSTLQAYFSYGMGVTCGIPSVTLEGEKADWERLYKRLDRLPELGDEPEQWAAMLRPILRRFVEAFDGQPDIPFWEHAVNRNDRICGLDLLSGWITAFCVWDQDGKWLARYRRAGTQSLGSIMTQDNYTLDGIPYFQLDMKNIPSGYGDVNVLVNDNGQKFDCKMVAGHVAATISKSSNDGAYDTLSPAPQWFLYVKGEKPRRGYEEEEAEMLERSMREFKLRFGKHQGGSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPD2</accession>
    <name>A0A4Q9PPD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YcaC protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_638767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPD2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPD2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053152">
        <property type="entry name" value="Hydrolase_YcaC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43559:SF3">
        <property type="entry name" value="HYDROLASE YCAC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="2">
        <location>
            <begin position="14"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23302" checksum="E8F8ED45ECBEA507" modified="2019-07-31" version="1">MAFTYERIDKNNAVLLVVDHQEGLYQLVRDRSPVDVKSSILAHAALGKIFGLPTVLTTSTETGPNGPLPAEIIAMHPDAPYIKRQGEVNAWDNADFRAAVEATGKKQVILAGITTDVCTAFLALSLVEAGYTVFANSDASSTFDVKTATEANQRMRKAGVQVLSMFAVALELMRDWRNTPGTKEMMPFFDTYLPEYGFLARAHDAALANGTSSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQB5</accession>
    <name>A0A4Q9PQB5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_616654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQB5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="257" mass="27605" checksum="DEEAE21E1603BA2D" modified="2019-07-31" version="1">MSRSRGPFVLRCGEPSSRYSTRNPKMYGSHASEVLRSASALDLKRSPPPTGKTNTRWSYEHFGAAADTSSIWVIEHIVLGGAAHACPDKVSCLNDCGEVCFFQGTAALPNPPNAFAEEGDIIPSDIVGSRGERRSKPGLSLAAFVSWRTGAIWGASPSSCQAWYTRLSQVSLVAALNALTRLKSPVNLSTEGGNLETPLAGYCLRDDPEDQAIKLCHPSIDSSMPRLPRSHVTLPLAVIEGNLPPFYDSHSIVNDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQH8</accession>
    <name>A0A4Q9PQH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribosome biogenesis ATPase RIX7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_978695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQH8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQH8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19518">
        <property type="entry name" value="RecA-like_NVL_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19530">
        <property type="entry name" value="RecA-like_NVL_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000018">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="138"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="477"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="752" mass="80971" checksum="FA7ABCFDAB0FD749" modified="2019-07-31" version="1">MQGLWSTHRRAKVNLNSASTLPSDSGATTPIAHAPTEQPATDSTPTDTPLDTPTAEAEPAVASLEQKPVSAKRKLRSTREDGGKRAKLSAGSVSKDHSPPLTRLSDLGGVDACIEKMLELVAMPLCHPEIYLHTGVQPPRGVLLHGPPGCGKTMLAHAIAGELGVPFINVSAPSVVSGMSGESEKTLRDTFEEAKRVAPCLLFIDEIDAITPKRESAQREMERRIVAQFLTCMDDMSWEKNDNKPVIVIGATNRPDSLDAALRRAGRFDHEISMGVPDEEARAQILRVQSARLRLEGDFDYVALAKATPGYVGADLAALTGAAGIIAVKRIFKQISEGTLTLPEDVLPPTDGDTSMAVDSPAQPPPPVLQNDINKAVPFASFDVSKHTAASSIIHFLRAHPNPLTEAQLAPLCITYADFIQALEHVQPSSKREGFATVPDVTWADIGALHATREELHMAIVQPIRRPELFSAVGIVAACGVMLWGPPGCGKTLLAKAVANESRANFISVKGPELLNKYVGESERAVRQVFSRARASSPCVIFFDELDALVPRRDDNMSESSARVVNTLLTELDGLDARKSVYVIAATNRPDMIDPAMCRPGRLDKLLYVDLPSADERVEIVRKMTRKVPLGSGTGVEGDSGAIQLMIEELVRERCEGYSGADLAALVREAGVSALKRTLGTLEAMEAEGDFGPGQEQHTVLVSAEDFALAAEKVQPSVSAAQRRKYEALRSKFAGLPVRSGKEEDGKRMEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRK6</accession>
    <name>A0A4Q9PRK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_949669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="239" mass="25897" checksum="DB8EE53AA4AD7FEA" modified="2019-07-31" version="1">MDVISEDGTLVEEDTQSERATSSPTQPKTVNALSPGQERKLVDYLEERFLDITRNFKKRADPSSSLPTLPAYLEATHHLLSLILQVPPVDPSAPLRTTLLLRLTGDVLAAVPGYVPTLDVLPLLLSWLADLDAGWLAVLRSQAWDPTSSTAVDARLPEGARASTPSQTERTRLRSLLIGGTDALEEWLERLDTSGAGFEMVLEKVGMEQAFNELFAGTLAEMGSLTGALNDPRGMEAAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS77</accession>
    <name>A0A4Q9PS77_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription and DNA repair factor IIH subunit TFB5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_929674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 7-subunit TFIIH core complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB5 family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU57267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PS77"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="C:transcription factor TFIIH holo complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nucleotide-excision repair, preincision complex assembly"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="TFIIH_TTDA/Tfb5"/>
    </dbReference>
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        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 5"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007470"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU57267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7411" checksum="664F6649ABAC3308" modified="2019-07-31" version="1">MKAIRGVLLTCDSAVKQILLTMNEKGSFIIEDLDDNHLVIKADEEYRVRRELEAELEKNTYSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTR9</accession>
    <name>A0A4Q9PTR9_9APHY</name>
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        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_820651</name>
        <name evidence="4" type="ORF">BD311DRAFT_659303</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143406">
        <property type="protein sequence ID" value="TBU30398.1"/>
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    </dbReference>
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        <property type="protein sequence ID" value="TBU57907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTR9"/>
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    <dbReference type="OrthoDB" id="3223751at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="133"/>
        </location>
    </feature>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="17"/>
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        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU30398.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU57907.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="274" mass="30761" checksum="718DC453084B9D07" modified="2019-07-31" version="1">MSAPIPLSPGSTLAQTRPVSPSSNPRSSPGTAVKEPHAGSSKQFVRTPSPVDEPALRHSTFYIEDELIILRVENTLFRIHRYFLERDSAYFKDFFQRELVMGAGKTDRSAIILPDVSKREFECLLYFLYHGYVFPQYDSILDLVLLLSTASQLSFPAARMHAIAALDAASPPLDPVERVFLAEKYGIPAWLRPAYVELCSRAHALEDAEAEVLGLQTTARLARAREAVLEEKVAEWKKAVERMENGQGVSKEDMQVREAKLVERVVDEIFAPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU68</accession>
    <name>A0A4Q9PU68_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_949015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU68"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37487:SF2">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020922385" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="19065" checksum="E5AC25EFCE2AE5C5" modified="2019-07-31" version="1">MKSVSTAVVAAALLVAGVSAQFQINTPNPPTQCVPVQLTWSGGNRGQPGAAALQQYSGLTGTSFTWPTNITSGTSIGFTLTDSTGATAQSAPVTINPGPDSSCLNGGSASSSASGATSGASTSATAPVTSASGATSASGTTSGAATTAGSSKPASGTTSGSASGTASHASSSSSSTATAGAGNGAFSNIASAGLVGIVGAIAAAILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV03</accession>
    <name>A0A4Q9PV03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927534</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV03"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7693" checksum="C514E00E5B94D770" modified="2019-07-31" version="1">MGLTYVAPQESCRVPASHLPLCQLRISFFRCAEHETVVSTRVREIPWISYMKAFADQGEQTEVSMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV20</accession>
    <name>A0A4Q9PV20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_948812</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV20"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV20"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="510" mass="55238" checksum="100BDE6979AAE779" modified="2019-07-31" version="1">MKLVVRVQYVGERARLLLREDQAADYTKGLIDDLEVFGFPVPHEQKPIEKSGFMLCVWHVDRDSDIHRMIQNAFMKAKAEAASLMDRSIRYISLNEDGVMHTTSLAHKPYKPKPHNKPAFGFGNHQIQDVKPFGKAPKYPTTISQARKGVTPLSQRIAGIEPSGYSAGSSSYYADHSVRDVDMHYMGARTPPFANGSDTSSNSVIDVTQQALAQLSQSSALQSLLQRGQSTPTTVKMEPAPPPDLSLPPRPTAAPSTQPQFSNLQALLEKAGVKSSSAQAFLSAQNNGLPAKPSLHVSGASPVPMSNAQATPAVFTPSSISSLGTQLSMPAATNAFTSLASPSSVLASRPASIGASGSRPHSTTPSAPPRGPAVHAATRELWDVRRQISALQAQESDLELDLRRAGQPVPPKEGSNPYVSEQRVRALEDEIAALREELGREQQNRRVQDALLRAERVRRAELETMVKDTTRECKQPFVVPALLDAFMKIGQMTGDALKDAHGSAVHPMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW22</accession>
    <name>A0A4Q9PW22_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">TBP-associated factor 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_819027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW22"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08045">
        <property type="entry name" value="HFD_TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045144">
        <property type="entry name" value="TAF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007900">
        <property type="entry name" value="TAF4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15138:SF14">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05236">
        <property type="entry name" value="TAF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="257"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="349"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="349"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU58676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="436" mass="47028" checksum="7C3E5E390D8A0912" modified="2019-07-31" version="1">MKAEDSQQSPPTTTTFSAATWPTAKIPIDPALQQQSQHPQHTATTPYSHYQYGHYQTNYSHYPQYTQQTHQTQTAPATQAQAHVQTPQVAQTNVSTVVRPLAQAVPQTQTQSQSGVDTTDVATLNDALGSAGVDLRAEEETLQRTNDQYYSYRPYEDRSRKQPDKPHFDTMYLGSKMRATGTTHKVSTVSKESIDYVALALRFRLQGLITAMIAAARHRTDTQFDRPPSTYEDGTPMWSIKVRSDVGKQLEALQKAYREEDMKERRERKERQDAQAAQAAALTTTASGAGTDGAAADGEDGGGPKKKKKKDGPGVTARNMSEDVRKKMSNAVASQAAGLGTGKYAWMSAASAATAAPPKPKPAVAARASTPATTTTPAASSTSAGGWARPYQPKSASQQAQKDDDGRLAVTLRDAVFVVNNEKGHGGGRGAARGWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWZ4</accession>
    <name>A0A4Q9PWZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heme oxygenase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_425757</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWZ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004392">
        <property type="term" value="F:heme oxygenase (decyclizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006788">
        <property type="term" value="P:heme oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19165">
        <property type="entry name" value="HemeO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002051">
        <property type="entry name" value="Haem_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016053">
        <property type="entry name" value="Haem_Oase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10720:SF0">
        <property type="entry name" value="HEME OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01126">
        <property type="entry name" value="Heme_oxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00088">
        <property type="entry name" value="HAEMOXYGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="39396" checksum="70E2D7BC606D94B8" modified="2019-07-31" version="1">MSSNKVPTAGVDLSQPIATVLREGTREAHQRAEHSQGAQSLTRGELDREEYARFLMLLWHVYDAFERALEQHATHPVLAPTHNPGLFARSANLAADISYILQVPEPSWQAHPVHAALVRAPPPALARYVGRIEELAAGPDPARLLAHAYVRYLGDLSGGQFIRRRIAKAYGLEGGVGGVSFYEFRTLTGSLESANAGEMKRIKEWYRDGMNEGVGDNAELKAAILEEANLAFEFNTGLFDELKPPSRPSTIATTATVDVVPTPLHSPVDSSSPPSTPFVEDMGDSPELAAIKARGGSKTVFEATEGPTSSVTFAATSVIAFIVAFSIAHFTLVVGGFTGSKGYAKLEIFTQWLDNFFGSGSSPAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX56</accession>
    <name>A0A4Q9PX56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925716</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7875" checksum="BB9C5361074B59A5" modified="2019-07-31" version="1">MDRSTSGRLLRIVGLLSTPVPAVGFNARSASGNRAGVCFRCHLCFSRHLHFSLFILSISTPLSYCCCIWAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY31</accession>
    <name>A0A4Q9PY31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_976387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY31"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY31"/>
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    </dbReference>
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        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42226" checksum="69305A8DC61E208A" modified="2019-07-31" version="1">MAQDPGHRYTAFEPQIPDIPSVVEFVSTTSFWEAARPWLSRRGIELYEKPPQENPAKFRRTWWTPSVSTPASLPFARCVIDAPNTQKVFDYMIKLACGQDSVGRDVMLKLVDKNSPEYSIFQCLMQQQDLCTDPSTFPCVLPPLAILDTPHQYSIVTMPTWGSPFYIEEFQTMREVLHFMKCLLQGLVFLHANRIAHRDIFEYNVVVNCYRLDRDMDRLSEDLVDHRRRPDVLYALMDYDQSIYLPQVTSLEHCRRPAQEAWAGADMYRPDDRFTAEQALKFLNDSAMDVPQDALEAPLELGMEYGAMFDSEVYWSRLPPGLRASWTDYRAPPLPRSFWILNWLIQIPIFRRVIVPGRRFLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZL0</accession>
    <name>A0A4Q9PZL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZL0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7439" checksum="8E9E75E2331E11AE" modified="2019-07-31" version="1">MGSSSGSLAIASLSSSLRSRRRIYDFLRPIQQHANDGGAPLVTYSAAATCSRWRSSPPARTTDGWSTIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0T8</accession>
    <name>A0A4Q9Q0T8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_947303</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0T8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0T8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="408"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="170"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="344"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="469" mass="50189" checksum="6A6158BA6BA78F34" modified="2019-07-31" version="1">MPPYSNASHNHAKPFPSSQNAVADRPPRSSVASTTSYSTLGHALASDSSRAPDTQYYRQPPPDPSRPPSQMASDSRYMYHPQEVPPAPSYPYASYPGPPYENGQYAQGSSRPPVRSPPPAQPVQHAPPPAPYNGAPPPYPPQPGYPPPGYGPPPQHAQWSGEWNQYGVPYQPPPQQGQPPYPPPTSARPDVSPGTSNDDRRYQQAPPRAEPRRTEERPPQRPEAAPPPSAPVRKTREEPPAPAPAPAPAPPPPVPIPASQGPPPPQAPQAPPPLTASPIGIDFVKLVESYRLILDTASTIQYEAPTRPSPPPEALERMFQAAAYGAQVLDVASKRVAPEPPRPPVDRPPEEAERDAGGGRQSENPPATEGQTCLGCSATSTPEWRRGPMGPRTLCNACGLVYAKLIKKRNRDGTGRGRGKNQNNNQNAGQNAHQAVADDAGAQSSSDDDDSYGSQQDRRSDGGYHGGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q114</accession>
    <name>A0A4Q9Q114_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Etoposide-induced protein 2.4-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_875037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q114"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q114"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059112">
        <property type="entry name" value="CysZ/EI24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389:SF0">
        <property type="entry name" value="ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21389">
        <property type="entry name" value="P53 INDUCED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07264">
        <property type="entry name" value="EI24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="401" mass="44293" checksum="EB5C3367731A8849" modified="2019-07-31" version="1">MSRPPRRPRPQYTPPSSSEFIQAPQYASSRSTYPTFLSLQETAWLQLSCAGRGLVDAFRWDTVVRLAASDSEVRSNVFKSLMLNTVSLVSIYFFDWLLLPLAQSQQKWFHRNLGWFYQVLWLLPVVGISFYLNSSWCTLIAKRTFTIQHGTRAAAQPPSTYSGMLNALATSAYRAVMVFTSVVLSFALSYVPYVGPPAGFAFLCWVDAYYCFEFIWIARGLSLSRRVRHLEERWAYYFAFGLPSAALCTWGSSLANAALFALFFPAYIIMAMYAKPVPLDPYDPTSSARGGSGNDDTIHYPSPLIPIRIPVFAPVIFLNDWIVRILSVGAGGSASASYSGSGRGGARHQHAPSDGAESIEEGEAVDMDTMSARSPAGDTGRVRIRGLGQSVPAARTGRKFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q115</accession>
    <name>A0A4Q9Q115_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_775735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q115"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q115"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="26464" checksum="662D796AEE17BBDA" modified="2019-07-31" version="1" fragment="single">RADPSAKLLEITDSKTVMGGALEWKQRHEDQGYILQKNAHLERAIVAALRNRKARTAFKWVKGHRGHPLNEMADKLAGEASSKPTPDELTVEIPSRLMLSGAKLSCMTQKLAYRAIRSLKERNLCKRRRTETNLANVASGVKATFGVSVPSAAIWKAARSRHITFAARYFIWMAIHDGYMIGDKWLRPNMTDEQRERAICRRCENLESMDHVLFRCEAVGQSQVWALFEELW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1G8</accession>
    <name>A0A4Q9Q1G8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_921311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1G8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9418" checksum="BDBF29F0CB2F5F33" modified="2019-07-31" version="1">MLESMYLALFPSGVLWIVVSLPRGTSHRKDHSMLDLPCRLQDWCKQAVQTSRASPGSIVDRVINVVRILPRKDCFSLPYHSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1L9</accession>
    <name>A0A4Q9Q1L9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_814518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1L9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="98" mass="11039" checksum="0392C9D4E55C6EDF" modified="2019-07-31" version="1">MVPTPLVGIQSHHHCGLTKTSLVRCRGTRIAFEPDHNVRGHENGILLRSLTFDQRDCDVQCANRPFRLAPSPKFMALADRQVRPKRKPVASSRIQAMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q274</accession>
    <name>A0A4Q9Q274_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase pc-bph</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_814004</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q274"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q274"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="540" mass="60307" checksum="C267BAA9C15BCCD2" modified="2019-07-31" version="1">MSLVDRLLNFEPATWAVVGFTAVLLIHFVPYLADPHHIREYPGPLLAKLSDIWLGYVAAQGHRSERVHELHKQYGTFVRIAPNHLSISDPEALQVVYGHGTGTLKSDFYDAFVSIQRGLFNTRSRVQHARKRKIVSNIFAQKNVLDFEPHVRQHLANLFRQWDKLCEGGKNGLSGDEGEGGWQGRDGRVWYDCLPWYNYLAFDIIGDLAFGTPFGMLDACKDSAPVAVSHKAAMAAYGSSDSSKEIQIEHFPAVQVLNDRGEYSAAMGVLPPHWRPLAKKIPWYSKGNQAVQKLAGIAVAAVAQRFANPSDRADLLSKLQEGRDDNGDPMGREELTAEALTQLIAGSDTTSNSSCALTYWLAKNQAAQRKLQQELDAALGSDDDPVASYEQVKRLPYLEAVINEALRIHATSGIGLPRLVPEGGLTVCGKFFPEGTVLSVPTYTIHRDKAVWGEDVDDFRPERWFEQDKNLVQKTFNPFSFGPRSCVGRNLANLELLVIVASIFRRYHFVLENPNAQLETREGFLRKPVECKVGMKQRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q291</accession>
    <name>A0A4Q9Q291_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_235075</name>
        <name evidence="11" type="ORF">BD311DRAFT_776089</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="3"/>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q291"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q291"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="10">
        <location>
            <begin position="46"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="9">
        <location>
            <begin position="194"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU31407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="443" mass="50015" checksum="0B612DC661C4AA7B" modified="2019-07-31" version="1">MGINIAMICDFFHPNVGGVENNIYMLSANLIRRGHKVIVITHSHPPDRVGVRWLLPGLKVYYIPFPTIASSATLPNYFTFLPYFRTIVLRENIQLVHSHAGLSSLGQEGILHAHLLGVRTVFTDHSLFGFDDAASILTNKLLEAALRNVDAAICVSHTGRENTVLRARLQPSVVHVIPNALVADQFKPPLKLPSEDTITIVVVARLAYRKGIDLLIATAPRICAMFPNIRFLIGGDGPKMIDLLQMREKYFLQDRIEVLGAVRHSDVRNVLVQGSIFMNTSLTEAFGIAILEAACAGLYVVSTRVGGVPEILPEDMISFANPDEDDVVRAMSEAIRIVSAGKHDPYQAHERIKHFYDWQEITQRTEVVYESVMASEPYDFWTRLNRTLDVGHIAGIIYAIILLVDCLFFMFLEWWLPEEQIDKVQMHWIPERFREVAEEHDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2J8</accession>
    <name>A0A4Q9Q2J8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_995343</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2J8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="754"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="781" mass="87578" checksum="77DCF27718AE3209" modified="2019-07-31" version="1">MVYQTDNLISAPAAHWIEAFDGLVAGPSFHSGSIMTSPNATFVPRFAIAHSEVTTFTDGRWGRHEYSRWPQAYDHDLAHVACIPRVHSELAPKDDILWQTWQQEDWTTVNSGVVRMGLLHAGLFDELERAALRASQAASDCQDLAPSLEYTRQFLLLCLRHCLDRLRTIPADRSVIIALAAHVQRLSLELVGLRVHHDVVSPRMTSTADYQDQLLDVVGAHTADPSLAQLLHRVGVPVWLHQPFRPSVAIWQVVPARDLPIQFSRKPAYPCLVLALRDLSGALNTAGEAQRAMTAAVYRQLCASQLPQLRPEEECDAAPGMKRPRLETQWPNGWDSTVGNARPVIFERDAREAKTLPHELKSPAPRMTYSKCRSARDRRPGKSSLPVIPPPSKLGFVMNPFRKQYASRTMQLSPVWLDVLTSLEPLPQPTAAVTYYFPPPWMLDCLDGYDAPRDRLLRYIQHFASIRMFCRLRLFDQTIAGRPLTISEWRDALWGDYEIGGHSAPDRSGATSKDAASARAKVRHRLKQSLRELFGKHAGLSSYDPASAPHVGQDVITAEVAETKPHIQHRLVWEAHKTNWRCELLALDALMTGSRNWGQMERWAREAHVSEVWGSPRSGMDICPDWESPHVHFCWSSPPEDDWESSRPHLKAFIELLSRWPGRPAELGDEDILVRLQVCDAKEFLRVQTVAVRYYVDTFIDKFQRLPTPPVRDGLRVASSLLPRSPPPADEVQGQTVPDTPSARPVRDGVRVASSSLPRSPLPSEEVQGQALPDAVTPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2Z6</accession>
    <name>A0A4Q9Q2Z6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_846710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2Z6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2Z6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="494" mass="54120" checksum="1F00F2781ACCFDCD" modified="2019-07-31" version="1">MSVSASATLYEILGVTKEATPEEVRKAYRKRALQTHPDRLPQNVSPADKKAAEEQFRLVNNAYEVLNNTENRKLYDKHGVWPPPAEQPDAGRSSARSPFGFPGDPFANDPFFSGHFGSGSHSRGPQWTFTDPFELFNSLFGDLHAAFDNDPFFANTPFTRSPFDDPFFHSPFGSSPLGDPFGGSLFCSSPFGGSPFGGSLLGGSPFGGFLTGPAMNSSNTRVYSSRSQTIGSNGRFVSQSQTTRTINGRTESITKRVDAEGNEHVIYSSPDGERYTINGVEQPSGGYIDAPRRSSTMPAPRSPPAAIADRPAEPPVNVVPPPPPAQSFNVPISSGPHRYSHAYAQPQPQPQPVPVVPPVQPSHHERRSSRHSHRERAMTEDPRRSSGTYVPPPTSPVDRDRRHSNQMDADPPMPGRYNSTSTRPSSHSHSHGHHDRHDPSDKRASKISTGHSPRHSHDGKDATRDRERERERGGVRDAGSPTTSTGSRRGWRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3J8</accession>
    <name>A0A4Q9Q3J8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_921656</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3J8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34808" checksum="85294BEE09966063" modified="2019-07-31" version="1">MGGIPPTPHLGLLAYATVLFLLATVGYCLQTWLNHRAFIIHRNADGGPYAYILSTSRDAPSLATVAIYVVLNWFADGMLLYRFCCIFSSSIWANLMSAAMLVSLIVVGSLCVPNISQLVDNLWTNTTTIPSLAYLTLSLSINVVLSVAIIVRLCLYRRQTFSSRVAHMYDSVVTMIIESALPYGIVALLTIVACGTSTPMQNALLPMLGQLQAIPPLVIMIRVKDYQISRDLAFTSTTIQFASPTATYERPSLDDKGSLPPYPRSCLVSSRSSVTSQKRPWDLTSESSSHRLSGFQPDFPRPVCPSCGLDMAIGEDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q490</accession>
    <name>A0A4Q9Q490_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_811617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q490"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q490"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="56950" checksum="FA4823378F1498A8" modified="2019-07-31" version="1">MLHNLPDELWLEIFDMAVDDSSLFEPTLPTAFSEASWFKSLYGDWSLRTAQEEVNSAQRKSYATKKAIMNTCRNWRRLGYEFYYRFLFFSNPRNIQRLCALMDTTKDLGKWTRRLHVTRYFATGGASSETIQNSLVAVIRHCPKLEIFITNWPLSISFSAIANALCTYSVETLRVLQINIPTLSLPKLIYMLQCLPKLEVLHVEFEGAPPEYLPLGAAGDLELNLPCLQHLAIRGPFQDFVEQAIAWRLPSLRLLSLDFINYREDFPDIIEFLTEHGQELTFLDLNCIPPLEVSSILDLCPMLETFTFNPDWRLGGWEHHPFLESHLVNQPHANIKTIGLHHLMYAFGVGYAATYNKVDPFVTQSIRRQNDVNFAALNKRNFPRLERIRVLNPTLLTDLEKNNGPSQACFERWERWSRQCQKNNVRLEDCTGAPLGTLPEVDEEEEDDESAVGEGELHLSTLRELLLECRKMNAEREQETFSPALHMIYAGATQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4U0</accession>
    <name>A0A4Q9Q4U0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_118927</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4U0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="98" mass="11253" checksum="031A31DD7F7FBD0C" modified="2019-07-31" version="1">MHILSRFPQHPQPLLQISIARGTCLPKITYPTAMTSSHGPISTCHCIYSHLDFVLLASPLYAYLPLKWLSHIHRSSSIKTNSITDMVSLRWRLWVRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Y7</accession>
    <name>A0A4Q9Q4Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein S12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_945978</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Y7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4Y7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="193" mass="20811" checksum="33B4974AC55B0AD2" modified="2019-07-31" version="1">MFSALKLTAQMARPWSASIQLHRAAAPGLARTVLPFAFSRAFHPTLPPAATLNQATRRKPKKRVKQSKSPLLEGNTHKKGVVSQVVIAKPKKPNSAKRKVAKVKLSTGKTVQAYVPGEGHNLQDHSVVLIRGGRTQDLPGVRYKVVRGTLDFSGVVGRVTARSKYGGMSGVALNCGTSLRGPFVFAAKRPKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6X1</accession>
    <name>A0A4Q9Q6X1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_623886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6X1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6X1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051651">
        <property type="entry name" value="DMTF1_DNA-bind_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46380:SF2">
        <property type="entry name" value="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="28"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="235"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="349"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="675"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="701"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="730" mass="78546" checksum="D0AECC9DF701C156" modified="2019-07-31" version="1">MTSTSATSAPLASLSDDIQRALQQAVGDANNAANAAAVQAKAKKSKRQRDEAGDGTVAEDAGNVRKKKKSKHRDASASASAEQAGASTSESPSGSSNERTPGAVSGAGAGVSNDTPGASPDITATAPSKKKKKGKGKERAHEDQSQSQPISLLSAPDALAPAQVVPTQGEIPQAVIQQPVPTTSSSGVPMDLATSSADFISAVVAAASATAGQQPQGGQSLDQAMQQYMAYPPPEFDPYAYAGPPPGHPPHPPSGLPPAHGQPHHPFPAPFPDMTGILPDLNFASSEDLLRSLQEFDISKVVTVLKTLGEAAAAANIHLNGPPMFVPVPQQPPPPTVQQQPVLSEAILGRPPKQKKGRGQGANGAGGTGEAAPPQPDNPDHAHMLANVWMNASKLAEMVRTEGLVYKKGKFSATEEAQLAAAIERYRVKKGLSQAELDQIVFSNKVGREKGHESFWSEITSALQLRPIIAVYHHVRRTRHPYAGKGTWTKTEDELLIQSVQDLGQQWEKISDIVQRTAADCRDRYRNHLQDRDVRRSGTWSKEEEEELTRIVTEMTVGQGKDMDNDIFWGVVSQKMGGTRGRQQCRIKWTDSLAPQLKNTGERPRWSAMDAYILVHKVDSMNVRDDTEIDWKLLPDENWNVWSAHSLQRRWLTMKRSIKGFEEMSHAEIMEILKTKKAQSPPPSSISRKKKSKFTSAEAVNDVDDVEMEGQPEAGSSSGPGTFVGAAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q754</accession>
    <name>A0A4Q9Q754_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q754"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q754"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="335" mass="36176" checksum="B7D32E5ECE435B66" modified="2019-07-31" version="1" fragment="single">MSSSIRPSRGRTAPPPARPANASSAAGSRAKPDESRVKSSTTTTSASRARTQNNAARTTVTKATTVQAPTRTRAEPPSSRVRATTTVKGTLPGAASNTSSSRPPSAASKEHTRPRAQEVASVSEHSEALQGAAQSCAWKYMASTLEVEFENAENIARATLNTRRDELAAEEADIAESRVRFEAERLIQFYDELGDREVADEIATIVLRYKRLEKTVSETTAAALQVSSLPLDEITHVSQYSNVLDQIGTSDDGRSVHFSDINVAVESLEDECRELEVLVHSLLTTTTSFRSDKLPTVLRDISDIIAGHAENAACARDVVQCSKENYRMGIGTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q869</accession>
    <name>A0A4Q9Q869_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_841358</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q869"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="388"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="38"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="535" mass="59239" checksum="82F97A526880DC59" modified="2019-07-31" version="1">MGTGPTVDLAGKDGGYRHLLDPNKKWYNNRRLIVLNAWLVLLLITSSTNGYDGSMMNALESEKQWNTFFGNPEGGKLGLFNAIQNIGSLAGYPFAPYVADGIGRRKSVWLGACIMCVAVAIQTAAQSFGMFIGARFLIGFGLTFASNAAPMLVTELSYPQYRAPLTSMYNGLWIAGSIVSAWVTFGTQFMSGTWSWRIPSLLQGLPSIIQVCLVLFAPESPRWLVSKGRDAEAIETLAYYHADGNKNDPLIVYEYEEIKAAIDFDRRVAANVGYKSLFSTPGNRRRMRIIIALAFFSQWSGNGLISYYLSRVFDTIGITSSVIQLLINAILQMWSFFWASFGAFTVERFGRRALFLSSVAGMTLFFTLQTVCSSIYAQRGSVAASHTVIAMIFLFGSCYSVAFSPLIVSYTVEILPYSVRAKGFNVFNFTISLALIFNQYVNPIALDKLGWKYYIFYVCWLAFEGAYCYLFVVETKGLSLEETAALFDGDDAAERIAQHAMQLTGADVREDADTEKEKASVGETKEDFGIAAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8H5</accession>
    <name>A0A4Q9Q8H5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_869116</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8H5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8H5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036121">
        <property type="term" value="F:double-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061749">
        <property type="term" value="F:forked DNA-dependent helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032042">
        <property type="term" value="P:mitochondrial DNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18799">
        <property type="entry name" value="SF2_C_EcoAI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050742">
        <property type="entry name" value="Helicase_Restrict-Modif_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396:SF1">
        <property type="entry name" value="ATP-DEPENDENT HELICASE IRC3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47396">
        <property type="entry name" value="TYPE I RESTRICTION ENZYME ECOKI R PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020511025" evidence="3">
        <location>
            <begin position="25"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="53"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="284"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="714" mass="78322" checksum="7A782580D3DDCBFD" modified="2019-07-31" version="1" fragment="single">MRVGSGSPLLCSMLRLWRLRISTAGHWRCYTAGVGSPVVLRPYQETCLQACVDALERGSTRIGVSLPTGAGKTTVFISLLSRLPAPKQAPDATRSLVIVNSVELARQTAEQARRLFPEWTVEIEQGKQQASGLADLTVATFQTLLRSQRLGKFRAQYLKGVIVDEAHHAAAPSYRRILSHFDSAIKSPDDEFEPPALSHRIPILGFSATFSRHDGMALGSVFEEIVYHKDVVEMIKDQWLCEVRFTTVQADLDLSGVTVNTSSGDFNPTSLAHVVNTPVVNELVVRSWLDKAADRKSTLVFCVNLAHVNALTTTFRNAGVDARYVHSKTPAAERKALVEDFKAGKFPVLVNCAVLTEGTDIPNIDCVIVARPTRSRNVFAQMIGRGMRLSPATGKDYCRIIDFVDSEARVAGVVSTPTLFGLDPSMISDDETIESLEERNAAMVEADEETGPRTGAVTGNMSSPTAVKYIDHDDPFVLADQGSGDPSLRQLTRNAWVSCGGGVYVLECLGKGYIRITPAEGGDESDEEREDGGGGQVEGTGVVTGQEQNAKFVAHYTPPTLAKQTAWMLKISPYRKSRQILTAATLGDAVRGCDTYALNEILPGTVALGLLRTSRWRWEPASETQKQFILKRWKDRKVIAAADGLGKAMHTTEEGLRALKKGEAANIITRLKHGALTRFEKKRKQQAKIHLAQQKEIRRRAREDVRVGRLPLTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9A4</accession>
    <name>A0A4Q9Q9A4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MAS20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_807045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom20 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9A4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9A4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="582" mass="64103" checksum="EA436F5B7BAB6025" modified="2019-07-31" version="1">MSSSSRTSTVLTVGAVTVLSGLVAYAVYFDYKRRNDSDFRKKLRKEKKKVTKQTQQAQAASEAASEVSPAAIKQALAKIREEEIPATPDDKEGYFMMQVQIGDQLVQKGPSFYLPAACAFFRALRVYPSPVEFIMMVQSTLPAPIFKIFMELVNADVSMPTSETQSAQREEPAEEVASRVEGYYDHFPPKGMNVSIHAGEAQGNQAAKKILIASKDFEAGDIIYTEIPLVVALDADLEGKGTHCSYCFRPIEEGQAVASESDKIGAVFCSKDCQSKANISWHNMLFGRDSVLPPELDPGHGTDIDDGRETAQTAYVAWLQEKKAKRANILGARFVAKQIALETSKLIKDKSSPLQAELEQIAGGGDLYSVSDHMERLRFIEGHVTDEEIKHLKAVLGAALPGLEQSVTEERMAVLVGKMAYNAIGVCPDGGRDDKPVSEERPEDQERTRTPFGTQRQVGSGLYLVSSYLAHSCDPSTRPSFTVGSTQLQLIANRPIKKGDELTIAYVDVGQHPGESTEQARRRRRVELARGWKFKCECERCVSEVVEDLEKEDAELGIEKDEAKVEQVMRHETLPGAAMGPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9R0</accession>
    <name>A0A4Q9Q9R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_808564</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9R0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="89"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="570" mass="62909" checksum="11546A2E528A73AA" modified="2019-07-31" version="1">MTLDDQTLPARPGSIREEDVKLEEGHAVRESALSEGTFHQSQVVGKAIRKHFFCPPDATLADAVNRDADNVEFTDAEEKAVRRKIDRRVLTLVVSRSVMNVVSYLGNAHVLKAFNDNFGITNNNQWTLALSIFYVGYCSDDTPCSDAFSANMPSIGLLEMPANVLQRYIGANRFFFLSLTWWGLASVSFVYAKGYGGLLALRCAPCGLYRVLLGIGEAGYYAGMIYYLSFWYKRSELALRISLCMTGTLPGAIGGLLAFGIVRIQTKVLVGWQLLFLVEAIPTIFMAIVTLLFLPSFPFSSSFLTPREKAIAQARLNRDHRPKSHGGMTGWEGFKAVVNDIHAWLLMFMYASFNVGATSIVYFLPTLINELGFSPLASQGLTVAPYVVGWLMVVFQAWHSDKTRDRGYHIMLSTVVSCIGYTVLAVLATRGSGSNMIGGRYFALFLVVGGNYSLFPLVMSWAANVFSPTSKRGVGTAFIVSISNCVSIASPQVYFDANDNYQKGHAISAACLFLTFLPSFVLRMRLARMNKKNAAKRLAMAAEGASVMEIAGLERNEEIYDNDARYVFMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAG1</accession>
    <name>A0A4Q9QAG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_913029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAG1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="59"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="561" mass="63377" checksum="89DD153588BCA74F" modified="2019-07-31" version="1">MPHSNSIYRGRRAIGKHILPACSSDLIADTRTSIMMLKSVDAARTSWPLPTSDSPLHRYLPPELLIEIFARLHPEKRDEIHYLHVCSAWRTLLLKTAEFWVDMLRIPSIMGYEDRPPTDIDIEFANTFMERSASLDIDVTVHISPKLTPAAFASRSQRILSLVLYIESQYAADLFQVLTTGMPHLRQLVVHHKYEGLNHPPRFPSETTKLIRTASFALPSLRDLRIPFAFLAPGLANSSLRTLAMGGCYCSDCIGSSVTLDTILTFLEKCPSLEDLHIKEEGRKPHVSSRSPVALPSLRKLALGGDDFWSSNFIDIPAILRHLTLPADIAVKIRYPYSDQTYIPPMRELPIVSLLDRLYVRFIKARGYKIVKVEGWIADATKIDLESRMYSHPGHDTVDQLVNTFGSQIVKDLEIWVSGPGVYKEMGLRGGVEQLLRGFPSITRLKVRRQRPDELFVALASVSRAGVPICPDLKELVVHWKLAPGTTVYEEDFWSVFDRIESTLLQRASKGHGLARFVFRCEDIQRLKPAVPPEELKQRLLVKLSSVAEEVVVNAYIETKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAG2</accession>
    <name>A0A4Q9QAG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_973088</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAG2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="311" mass="34354" checksum="E23B81EA074AD07D" modified="2019-07-31" version="1">MSLSRSLSLAGSLLGAVCNLAFALRLLTLSRSLGWESESEWEGSVDVWAVDSVRLVWGLLFAYFAAAAASCSIGFIGIAKHVRPFVRIYRDYSIADFVFVTLATLGVSYTTFSKPYVRSSVCEELSRHPELMRDMGEMGLSLENCEQWFERAVVAVLGIMFILIVVRLHIVIALSQYYSYISRELLAGVRSHILGMRAIKTDVPLQRIYLMPTPTSPSASSDGRSHHFSTPTKDITVYATVPIGAMSEEDARKMHATPAWITTSPVASSSSTPRSHRHSHSHSHSHARPHTHSHRHASSRTLSDEKAPTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAL6</accession>
    <name>A0A4Q9QAL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="6">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_915730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="6"/>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAL6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAL6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000001">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(P)+]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000940">
        <property type="entry name" value="PRK00094.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000942">
        <property type="entry name" value="PRK00094.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF1">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="7">
        <location>
            <begin position="56"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="8">
        <location>
            <begin position="239"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="414" mass="44889" checksum="217A2EDFD9DC8623" modified="2019-07-31" version="1">MLLASALTATFRFSARRPSLLSTRIPHGPHVRFRTRLVSPTGFRMLPHQQNGQRSKVLVFGAGNFGSCLADHLDDSSHVVHMWSRSENLVKHFNQYHRNPEVLQDHPFAESITAVGPEFPSAEMIQSMDVLLFAIPTEGVRETLTKLKPTLEGGKVPLLIFVNKGIEIRTRALTLEIIADTCGPEIAKVATFISGPSFAKEIVKRQPTSVSVVSLSPEHAEKASQLFHQPWFRCYTGNDPIGVELAGALKNVYAIAAGIAAGLGFENNARAMLITRGLAEMTRIGTAYGASPLTFLTLAGVGDLFLTCSSKTSRNYTVGYRLGQGEKLDHIIKTLGSVAEGVTTAKALKAVVDELGVKAQIAAGIYDVLYEGRDVAERANELLSLPPNRELDLSVEGGKPAQRLLKKLGLEAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB03</accession>
    <name>A0A4Q9QB03_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytoplasmic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_954680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DOCK family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QB03"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043162">
        <property type="entry name" value="DOCK_C_lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046769">
        <property type="entry name" value="DOCKER_Lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046770">
        <property type="entry name" value="DOCKER_Lobe_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046773">
        <property type="entry name" value="DOCKER_Lobe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06920">
        <property type="entry name" value="DHR-2_Lobe_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20422">
        <property type="entry name" value="DHR-2_Lobe_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20421">
        <property type="entry name" value="DHR-2_Lobe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2100"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2171" mass="244384" checksum="31CD736BA9C9DB0D" modified="2019-07-31" version="1">MTGTLGQRKGVWEPLPLIIYGYAVHPLSPVNRRDTKLSSRTHISTWTDASGDEHLVHRDVVSLEVGDNVYAFEKYIPRDKEVEGVWYRGYVVCTSRRPQVNWSLSSDPSPSNPKPSARADELQQVFIGIFPASHIFVRDEVSDAEGRLTELFNALSSPADGRTSEEVFASWNKSMREMDPVREEEEDVNDAATRKSFKLTPPPDQALSTRARLPVYPASIRSASPTESQFNKPLPPRPTLTSGDDTLSGAAQPIIDEIASALREWHALMFQYLAQRDYRLFHVVREYIEVLHLGRRQLLSQTLSSEETVNLRRECVARLVSGNILQGLDVIVRHPTWGGLINVDVEGEIDHRSWMSAVRMYALQAALANMDVSLAPNTPYKLPQSNGSIDYSASVPTPVPLSASIHSAFPELPRPRGHSRLIGSLSPMSPTQQRAKFYHVFLDVRAFVASPCAPGETAELYFSLYNKADARFVSEEFCAVLNHNGVLARDPSARIRTLFTDLVQSDAQDPIFLVCKIVRNGSLKMSSNMGMISENPRQTVIGSSYNASMSSESFGRSSNSTDPQYFRRPFGCAVLELTQLNAMAAEQSEISSTREHTMPIYVPTNETTFSMLHQDILNHNVREYEKSPRAEMLAVSIKIFYGDAETIVRENSSLLQDTPLSLRLGFPDVVFPGDVRNELYIKLWSGDFSSSQGTTTRRNVANFARGQVGTVTGNVQVTMEVKDQDGRTIERVISQCSGEPEVTQFHSMVFQRTTQPHFGELVKLKLPLNGAQNWHLFFTFRQRSSRERSSSRNVETSERPFAFAYLPLFPDRRAFLEDGSHTLVLYRADRLAQITTDMYLQSTPWLPANQRPEQVYVPPELQRIAPPMRDSLVIRSSLCSTKFTQNSVLLSLLNWEQITDKELLSTILSKFTFVGEVEIVKFLRDIFDSLFAILVSSNNQSGEMDHLVFNALVTVLGIVQDRRFSNFQPVLDVYIERHFTCASAASHMIHSMNRLLQDPTANDTASSLRAAFKVWHYIFKFIARSRELQKAKELGMGGGATADHLEATFKRELRAHLNEVNRMMSTTSPPSIIGTQTIALQHFTSILPELGKVFSIVELVTIATTFANAIASTKGKIIIWKLIMYLQIVKGFLFDNPKSRSLLVEAVVIWIKPQFGRFDEYTQTQPGDSEAAKYAARVSWLESIRLSVTVVAIMLDKLQQCLVDPVITSDRNALRQEQYNIEYLLSLLPRLLDSYQEYQNPASLRAVERNRSSTPVTNNFPVTFPESYPFSLATQVPKTAAGSSSTLDVKPEFSPGLGEVAIVILVLILSAPKKHIVMFLESILEIEGRDHLATLLLQYFKVAGSILDNDAFPKNWLNVNILAHRVLLKMMDPIASMFEREFVPDEASGRPFDASLWKECFYVLLKLLSSEHLVIEEFSPQKRRAVWRLAGDIRGEGAMLLLRLWGALGWPDETATEELAIARYTNYQAALNTLVGHIVNLCLSHHDQLRENAVQVLYCMIIAEYHTSRSFEHIENELVSKLDTLFMSDSKNNEISRAFFIGHLRHLFDSSDVDEDLRTRVTHFLDSVDVFLELLLSVRALPEGEEYADDRVIATLRLMNFIRRIGRDEMYIKYVHQLVNMHLQSQNYVEAALTLKLHADLHEWDLNSFAPPMEDLGLPQQSQFHRKETLCLLILDYLGKGKAWESAYEICKDLAAKHAEVTFNYARLAEILRHQAALLEHIITDQRYYSDYFRVAFYGNFPNAIRNKQFIYRGYEWEKFGAFCERMLNKHPGAQLLKTMGDPPVDIRFGTDQYIQCTAVTPEPRRELPIFTNPDVPPQVRAYYEHSAINLFSYSRPISKMDRDGTEEVWIEKTYLTTEEYFPTVLRRSEVVDVQLVPISPVDTALLEVEQRTRELAGLNQKYSSLAKTAQHISTNVLAMSLNAAVDAPLNSGVGAFRQVFLSEDYLARYPDRAEQVEKLRNAIDEQVRMIDSCLKLHGQLCPQEMLAFHATLEKFFHKNFADEIQRLSVNSTPEPRAINAVPTSARLPPSAAMPSPNYNTICRRTQPLTVGPIHVGMTPSASTSPMSPRSQENGLPVAEAPWMKQTPLQRHLAHLARHGFNGVASGPGDNGGSDSFSEESPRNSVVTVGNAPAAAFSGAASVTASTLGSIGSIKGRFSKLGSLSFGRRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBT7</accession>
    <name>A0A4Q9QBT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBT7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBT7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="349" mass="37172" checksum="444587D5D16688C6" modified="2019-07-31" version="1">MRRTFQEKYASDLQVALDSGVPRSPGGRALKASFVPPPSYDDGPPPSSSSNVPPSSPPPTSSSTLTVPGSPPASSSRLSPARPPNVSSRRGHSPNPSISSVASSISDRSSSPKSEVFSPTILAEDVPGIEFIRETLYAALAEVLERRPGLRRLLRTDPARAYFASVALAVVDVASSSATKPNSALDKLREEGLPPSPGSRDPREPVLRGVLGQTLALSDCPQPLRPFMAELCSIGTKLHEMEEEDSAATVRALQRGEDPPVPRLERVYEILEKGVGHARRPSDVGTGRAGEREGEVLRRRRTSTEGRAVAFANRINALALGMTKLRAFRERQEMVFKVLAGVGGAGTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCG5</accession>
    <name>A0A4Q9QCG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_6523</name>
        <name evidence="1" type="ORF">BD311DRAFT_744182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCG5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU35544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7696" checksum="883BE35855B81414" modified="2019-07-31" version="1">MSCGRGRIGLRRRVLLSCTWRLCNKPLPQWHKLVCVACYCRLEEGVQRTCVGSCGARCWVRKTCQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD95</accession>
    <name>A0A4Q9QD95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_804177</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD95"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD95"/>
    <dbReference type="OMA" id="NEGLHGW"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="3">
        <location>
            <begin position="91"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="193" mass="21863" checksum="A65CDA8BD0B1BA61" modified="2019-07-31" version="1">MKRTIPLQEHPEFSIIDGYGWREFRVEAPGGRRRAASRLPSIGGLWLDACVVSGVAYCWKAATSTTPGMAVLFMVLLLYVYTRSTQIQWESVVIFPSIGIQLETHKGFAGVSLLASRKFVPWSSLEDFLINEGLRGWDVRYYCVAINRTLEGSLQLEVAFENILPRFPILLEVYHGVQEALQIEIERRTEPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDC2</accession>
    <name>A0A4Q9QDC2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_836969</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the histone H2B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDC2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDC2"/>
    <dbReference type="OMA" id="HAFSEGT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="13">
        <location>
            <begin position="44"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU65777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="15788" checksum="5C0F6B8BD454F650" modified="2019-07-31" version="1">MAPKPASSASKAPASTTAQKAPVKAESKVKKTAASKSTASAGPDGEKKKRKKTRKETWSTYVYKVLKQVHPDTGISNKAMAILNSFVNDIFERIATEASKLSSYSKKSTISSREIQTAVRLILPGELAKHAISEGTKSVTKYSSSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDG4</accession>
    <name>A0A4Q9QDG4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="8">ATase</shortName>
            <ecNumber evidence="3 8">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_911010</name>
        <name evidence="12" type="ORF">BD311DRAFT_707353</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H2O</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="3 8"/>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDG4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDG4"/>
    <dbReference type="OrthoDB" id="191723at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11907">
        <property type="entry name" value="AMIDOPHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PRTase-like"/>
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    </dbReference>
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        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4 8 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="11">
        <location>
            <begin position="2"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
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        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
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        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00011941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU35416.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU65256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="550" mass="58982" checksum="5FC5AE60E3E864EF" modified="2019-07-31" version="1">MCGILGLLLHDPTIDAASEICEGLSLLQHRGQDACGIVTCGHKGRFYQCKANGMVRDVFDATAISKLIGGMGVGHVRYPTAGSSNHAEAQPFYVNSPYGIVMAHNGNLINTASLLHFMDAVAHRHINTTSDSELLLNIFADNLQKTGKFRINEEDIFTAVGGLMGQVKGAYACVAMLAGFGIIAFRDPNGIRPLGMGSRKALGGGEGKDWLFASESVVADASGFSEWEDVKPGEAIIITRNGVTRRQVSPPATFAPDIFEYVYFARPDSVLDGVSVYRSRMAMGDALADSVARVLAQHNLSVDVVIPVPDTSRVAALNLAQKLGLPYREGFIKNRYVGRTFIMPGQQMRRKNVRRKLNAMALEFAGKSVLIVDDSIVRGTTSKEIVQMAKDVGAKRVIVASCAPPIRHVNVYGIDMPSRGELVAHNRDDAAIAAAIGADLVIFQTLPDLIASVRQFNPALAHFDCSVFTGEYVTGGVDEEYLQSLEQLRADNVKRRMELGGLGTMEGKGGGAVKHEPNGTVESREAAVGCSGPMNGADSTVGLHNTYSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFR2</accession>
    <name>A0A4Q9QFR2_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1034337</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU66156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9398" checksum="0FFC384A074C734B" modified="2019-07-31" version="1" fragment="single">VQSALQSCPAGKEARPSHSRPRRRRRRSWTRRTSPSSRGRKPRRPLSRPRATRLRRGVLLVAASRSASCPFSSLPFLAQWHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFW3</accession>
    <name>A0A4Q9QFW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_943316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9QFW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7736" checksum="4CE6DCB74CC6E06F" modified="2019-07-31" version="1">MTFNSILKGPDPPEDAHEYKRASNVMKLAEQNEKLKAELRAMTERLEAAERRQKDLEARRSGEGAGGAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K1L3</accession>
    <name>A0A4V2K1L3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_927182</name>
        <name evidence="8" type="ORF">BD311DRAFT_749436</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K1L3"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="96"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="533" mass="57879" checksum="F103A39F9A94EA98" modified="2019-07-31" version="1">MPANNQDSELPTEQRQASRTPTVSSDTHVSAQVTAGPDVDPVDVEKAKDASNLRGGEGLSAFPEDKKEEALENAEDDWAHDPINPRNWSTRKKWTMACIVSLYTFVTPLGSSMMAPALPDIAEHYHITSKTEVAATLSVFLATFAIGPLFLAPISEIYGRTWVLHINNLLFLAFMFGCAYAPTAADLIGFRILAGFAGSAPIACGGGSISDLFSEKERASAMAIYTLGPLLGPVIGPVAGGFIAQTIGFKYIFIVVAGLCAVAAVVGIPFLRETYHPVIRLRRAKKSGDPEALARLHPHLVQEHGNRMHRLWIDLTRPFILLTRSIICFLLSAYMALMYGIYYLMFAIFPDVFTGIYGFSVGVGGLAYIGLGVGFFLATLFGAWVSDGIYARLARKHGKGKPEFRIPSLIFGSFFVPIGVFWYGWSVQARIHWIMPIIGTGIFGFGMMTTFLPIQLYLVDTFTFAASALAAASVFRSMLGFAFPLFGSQMFDALGIGGGNSLLAGLAIALGIPFPVWLWFYGEKMRASSSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4A5</accession>
    <name>A0A4V2K4A5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_402491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4A5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="17029" checksum="23F2AC077CEAB0B8" modified="2019-07-31" version="1">MTVFCVNSRRGRHTCPMDDAQGLTYFVWMTVVPGGILFIDWRLDSGPFHLNGWTQLCADAVIRLTFLFARHRISASSFDGDRTEAVVLRVRGAHVESCVDGNIRSPSIRSFKFRQLRGYRKSPVLWGCRACRYNTYCTVARWCDDLLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K687</accession>
    <name>A0A4V2K687_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BD310DRAFT_942270</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="ML145331">
        <property type="protein sequence ID" value="TBU51383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K687"/>
    <dbReference type="STRING" id="114155.A0A4V2K687"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="23">
        <location>
            <begin position="925"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="372"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TBU51383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1104" mass="119851" checksum="62206D0EB9C4B32F" modified="2019-07-31" version="1">MAGMGPDSDIQTIVVVGLGMVGIAFIGKLLSLDTSRRYRIVTCGEEVHLAYNRVALTDYFQHRNVEKLYLESPDWYENQDPAHFEFYTGETVVALDTTARTVTTDTGRSIAYDHCVLATGSDATLPSYADTAIPGVFVYRNITDVNKLLAYAEKEDMKDASVVVLGGGLLGLEAAKAVHDLPTISDVTIVHRSAYPLSRQLDAQGGEIVLRRIEGMGVRFLGSTSATRLISDSSTGALTGLELMDGTVLPCTIAVFAIGITPRDDLARKAGLACVERGGIVVDDRLRTSAEDVYAIGECASWKGNTYGLIAPGIEMAEILAFNFTQAKTDVGEFKPREMNNPDLSTKLKLMGVDVASFGDFFVEQRVNAKSSTTHSHVGQISPSVNSSSRHDASAPKKRHGGAAAGDGPVEALTYRDPFGGVYKRYIFSADGRYILGGMMVGDTSDYVKLVALVKKKKPLEIPPSQFILGSRSGREDAGDDLDEDAQICSCHNVSKGQIVQCIKDGAQGIADVKTRTKAGSGCGGCVPLMTNIVKAEMKKAGIAVSNNLCPHFAMSRVDLFNVVKIKKLKTMTEIMAAVGVKPDSVGCETCKPAVGSILSSLWNEHIFDPAHNSNQDTNDRFLANIQRNGTFSVVPRVAAGEITPDKLVILGQTAKKYGLYTKITGGQRIDLFGAERADLPSIWKELVDAGFESGHAYGKALRTVKSCVGTSWCRYGIGDAVGMAIRLEERYKGIRSPHKFKGGVSGCVRECAEAQSKDFGLIATDKGWNVFVCGNGGANPRHATLLASDVPPSRVVQIIDRFIMYYIRTADKLMRTARWLESMEGGIEKLRKVILDDELGICEDLEREMDGLVGSYFDEWKSVVDSPEQQKRFRQFVNTNERVDPMEKIVERGQMRPANWSKTTPSLILRQSDIPTPKDQWMWRTVAKVQDLIPNEGGTTSAAVRYGDSQIAIYHVLHKGYFATQQMCPHRRAFVLDHGIVGDDPGSNALYISCPMHKRNFSLTSGECLNDSSYGIIVFDVKTEGDDILLLLPEPDDLNGVIGTAKWMVSQATAELLDRTSATGGENTLEIAGPTNDVLQGVSENVAGGGCSSGSYGDSKLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6E6</accession>
    <name>A0A4V2K6E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_862964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145292">
        <property type="protein sequence ID" value="TBU51713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6E6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="186" mass="20201" checksum="383F433B79691DC0" modified="2019-07-31" version="1">MYGGTTYGVAASVLSLSVNLFATVIVAYKAWISRRFIRKFMVSGDRTVQIERLFSILVESGMVYCTIWIFVVAWQVVVWQSTFSYNDSATAFEARFGDFINGGLVPIIAIYPAVVIILVAQNRSHMVKAFGGGAVNIPEPSRLNGIRASSATVLHIAQQGDDLGDISEESSTHAADEWKTESGGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6X3</accession>
    <name>A0A4V2K6X3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucanase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_951822</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains.</text>
            <dbReference type="EC" id="3.2.1.91"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 7 (cellulase C) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6X3"/>
    <dbReference type="STRING" id="114155.A0A4V2K6X3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016162">
        <property type="term" value="F:cellulose 1,4-beta-cellobiosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.100.10">
        <property type="entry name" value="Glycoside hydrolase, family 7, domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001722">
        <property type="entry name" value="Glyco_hydro_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037019">
        <property type="entry name" value="Glyco_hydro_7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753">
        <property type="entry name" value="1,4-BETA-D-GLUCAN CELLOBIOHYDROLASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33753:SF2">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00840">
        <property type="entry name" value="Glyco_hydro_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00734">
        <property type="entry name" value="GLHYDRLASE7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU53863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16403" checksum="C819DA00D01B4734" modified="2019-07-31" version="1">MICITLGSGPVSQCSRHHDERELALTLKFITNGPYSTNIGSRVYLMDMAYSKYELLNLKNQEFTFYVDVSQLPCSLNSALYFAEMDADGGNSRFSTNKAGVKYGTPGVHMTSNFATASNVRTDAAAEYYLEGSNWRYDAIPHRALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K700</accession>
    <name>A0A4V2K700_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_828491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K700"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="145" mass="16757" checksum="8B46D2B69ED3C354" modified="2019-07-31" version="1" fragment="single">PDEPSYLDPDEPSYLDPYQPSDLYPNEPSHFPPNEPPHESPHFSSYQSPHFPPDEPSYLDPYQPPHFPSNEPSYFYPNEPPHFPPHQSPYFPPNQSSDLPPYELAHFAAHEPPDLTARAPDEPSYLYPYQPAHLDPNQSPYFPSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7F5</accession>
    <name>A0A4V2K7F5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_960516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7F5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="37713" checksum="DFEC210B6FA01A8E" modified="2019-07-31" version="1">MSCWPDPTQSSYNVSLRINSSSSEINYVGGWTTEGIFKYSELSGDIATFSFMGTSITVFGKVTGPTMQASYGVDESSDSGVLCEVDDLHFRELPFQGPLYTSLPLGPGQHKLLITNKGIDFYFDHLEISNNNTISSSAQSPPLTPSMTTATLTSTAPPYESTATVFVPSTQISSLPNSSSAVAGPTENLPRPKSTLTTGEIVGVAATGWLLLLAVGVGLYWNRVKHGRKARSNSLGSCVEASGRSTESQSAQAMREARDDPISAFAEFHEAPPIYSSIDFHTNPSVGNSQSAPLVQANGAYVPDGTLNNNNSKRNAPSVESLLQQQRAARDTTRPGKNHMEIRMSDGVFREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8X1</accession>
    <name>A0A4V2K8X1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mmc1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_956832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8X1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056196">
        <property type="entry name" value="Mmc1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38644:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23868">
        <property type="entry name" value="Mmc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mmc1 C-terminal" evidence="2">
        <location>
            <begin position="430"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="645"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="676" mass="73203" checksum="4377FA74C71FE390" modified="2019-07-31" version="1">MPTCLASSSGLLRSSAQLHSSSTSRLGQSIHRNVRRCRTTACSVRRASTATAAPGKHEDQRAQVLTALHKTTALLPRVLPSARPSPNGVSLRESLDFWEEVLGKVYDDLTLAPEKREKDRVRVVVYGVDRRSSANELVIAILEDPFVSDEQRAILRSRWSAQSESNRMVKIQYGTSPSLDEDVIIVQSSWLQQFNVPIEITEFKHSVPSPSSDTESAKLLFTADVPIILCDPVSTPLASILPVSSDPPLPLSRENAILALLSPSPAYPATAAQHSRVSPLSSQENLHVIFVDPSRALHGLQVLADGIASPLSVQRYQDDVSGSNVASITNAVKDILSSVSGTSASAQVTAIHAQTGRALIKDALATAQAVLHKAELEANAALTATSELRGQMEEAKAKAHLEVFGAGGQDGDEIAKAVAQAKRSIKPTMDALQWYKLFWRVDDVREVVTAAVDRAWCRDLERKLVFHAGRLASLQTTFTDSANALARSFPVNSPYHSPVLHNTLARIAATPSYAVTATALTSPLHARQSQLGFPTERLHVSAQRAVVGMSGSILSGLGVAWAGWATELQMFGGMVDVGMSTETALGVGMLGTAVGVRWAVGRWEKAKRRWWKDWDRVGEGLERDLKATLTQTMDDRVVAVSEAACSALEKQVAERKVKIEELKDEVQSLRTTLDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVU3</accession>
    <name>A0A4V6MVU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930239</name>
        <name evidence="1" type="ORF">BD311DRAFT_765810</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143472">
        <property type="protein sequence ID" value="TBU24803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVU3"/>
    <dbReference type="STRING" id="114155.A0A4V6MVU3"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU24803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="321" mass="35523" checksum="11DBA9053A8E58C9" modified="2019-07-31" version="1">MSEHSEKHINAGIAAIRDQTISPEQAADVIAEQCRQALESAPTNDRVTQQGDTPWLENFLWVFWSKLVELAQEDSSVHDRTAHVLAALKAKGSEGCEGWRVWGSQTSWAELPLLGPVSREEMNGPQQWFKLRGTGSLDLSAPKAQGLLAGDDPTDDDPETREVIKARQKWLNLNAFLAQLWALGVVDEAFFGICSMAAGLEPLTLSSTRRPTREQAGVFDGPQELQIEVASVWLRIAGARMYACREILGPKGDPDWDARRGCPGRSGGTWDGVDGYHPDRWRYWKGILQEVAKGEWRMNVIKAAQAAVDAMNQFEREAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWW7</accession>
    <name>A0A4V6MWW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_811455</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWW7"/>
    <dbReference type="STRING" id="114155.A0A4V6MWW7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU62198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="376" mass="43055" checksum="EBBA468BE814FB7A" modified="2019-07-31" version="1">MPYGSWWRRHKRAFWQHFHPASIDRHISIQKKYTRMFLRKLLAEPSRLREHIRHTFSATVVKILYGVDVADRDDRYIALIGKVLSVVVAFTPGKYFVDVFPILQYVPKWIPGAGFQQDFETWRTAALEVKTMLFREATERVGAPGSSLYAEDAGRSVIAQLAERVDHETREAAFEEYEIIKNVGLTAFEGGADTTFSTLQSFFVAMSLFPEVQRKAQAEIDFVVGPNRLPDYSDRDALPYVNALVKEALRWQPVLPFSLPHSTTEDMEYSGYFIPKGTILMPSSWACLHDPEVYPEPGRFIPDRFMRDGQLDPDVRDPARFAFGYGRRICPGRHFAEAALFLNIAMVLYAFDIASPIDDCGKPTHIEPRMTDTMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MBF2</accession>
    <name>A0A4Q9MBF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_905460</name>
        <name evidence="2" type="ORF">BD311DRAFT_809835</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143476">
        <property type="protein sequence ID" value="TBU24604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MBF2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597574" description="Hydrophobin" evidence="1">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU24604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="10251" checksum="EBD35D0FCF23EAC4" modified="2019-07-31" version="1">MADFIMRFTALASIVLAAASAGLVNAATLEQRQLGSCSSSSLGLPLPLCGAVFGDCSGAGCECTELTSQIIGTIPGLSNVLDILDATGLDIGTLGICTTGGSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MLA1</accession>
    <name>A0A4Q9MLA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_843452</name>
        <name evidence="2" type="ORF">BD311DRAFT_761731</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143440">
        <property type="protein sequence ID" value="TBU26861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MLA1"/>
    <dbReference type="STRING" id="114155.A0A4Q9MLA1"/>
    <dbReference type="OrthoDB" id="3363533at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU26861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="217" mass="24962" checksum="1C46216AB486A2D5" modified="2019-07-31" version="1">MRRAQSVRHYARPSQVHNTDDLGVLREDESVEDVLRRQLLEKDRECDRLQIQIQSLQAQLAQRPPLEKIQALEKEYTNLELLLQGTQRENERCMAELERGKVREKMLERELEKLAGVNWQSNLELGTPTSASGFHARAASLINSGRQSSPVSSNKATNDQASVEATKAYVEQMRLMILGMEQRLQSREDKLTRHIERAEAEGARFEEVRRQPITTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MNC9</accession>
    <name>A0A4Q9MNC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_811208</name>
        <name evidence="1" type="ORF">BD311DRAFT_663158</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143420">
        <property type="protein sequence ID" value="TBU28627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MNC9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MNC9"/>
    <dbReference type="OMA" id="RHINTHM"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="98" mass="11276" checksum="4016BF992C737855" modified="2019-07-31" version="1" fragment="single">CDYCGHHQTNKRAPDMVRHIMSHFRAQMQAQWVCCGVPKHEAQEYGVDPTRNPWVFKGQVLVGGCHEGFSRMDALKRHWNNPNVQCNGSVQWSRPGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MPY7</accession>
    <name>A0A4Q9MPY7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_944343</name>
        <name evidence="7" type="ORF">BD311DRAFT_787776</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143412">
        <property type="protein sequence ID" value="TBU29585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MPY7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MPY7"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020785">
        <property type="entry name" value="Ribosomal_uL11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00359">
        <property type="entry name" value="RIBOSOMAL_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU29585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19314" checksum="B491DCE3057A1909" modified="2019-07-31" version="1">MAPKLDPNEIKIIYLRATGGEVGASSALAPKIGPLGLSPKKVGEDIAKATGAWKGLRVTVQLTIQNRQAKVDVVPSASSLVIKALKGMFEVLVLDGSLHNHVEPPRDRKKEKNIKHSGNITFDEVLDIARTMRSKSLAKSLANGAKEILGTAQSVGCTVDGQPPHDIIDQINNGEIEVPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MUC0</accession>
    <name>A0A4Q9MUC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_855389</name>
        <name evidence="3" type="ORF">BD311DRAFT_690156</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143403">
        <property type="protein sequence ID" value="TBU30798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MUC0"/>
    <dbReference type="STRING" id="114155.A0A4Q9MUC0"/>
    <dbReference type="OrthoDB" id="6419443at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="80"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU30798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="244" mass="27575" checksum="00DCC38E159DE0E8" modified="2019-07-31" version="1">MSLLQDVLRTQTLESLEKTITSGRTSPDDDDELVNVMSLPGSPGMSRPGSRPASRPHSPTRGSRPSPLQPLSGLKSGPSRDPLRVLPTDVSQRVFSHLSIRDLARCSRVSKKWNKSQTLNYVWFQHYRKENFHDESLPPGKWTKRESKQNWRTTYLTTIPNRSPPQSPRSGYLTPLRSGQQTPREIREEKWKQEVEGAARPSKVEMREMYKELGGRKARGKGKLGGTAGMRDRGGWGEVSIEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MUR7</accession>
    <name>A0A4Q9MUR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine dehydratase</fullName>
            <ecNumber evidence="12">4.3.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_393770</name>
        <name evidence="15" type="ORF">BD311DRAFT_656322</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from L-threonine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.19" evidence="12"/>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MUR7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MUR7"/>
    <dbReference type="OMA" id="TRFEYTK"/>
    <dbReference type="OrthoDB" id="4418812at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00054"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04906">
        <property type="entry name" value="ACT_ThrD-I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04907">
        <property type="entry name" value="ACT_ThrD-I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01562">
        <property type="entry name" value="Thr-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1020.10:FF:000001">
        <property type="entry name" value="L-threonine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000005">
        <property type="entry name" value="Threonine dehydratase catabolic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1020.10">
        <property type="entry name" value="Biosynthetic Threonine Deaminase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001721">
        <property type="entry name" value="TD_ACT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038110">
        <property type="entry name" value="TD_ACT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005787">
        <property type="entry name" value="Thr_deHydtase_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01124">
        <property type="entry name" value="ilvA_2Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006674">
        <property type="entry name" value="PRK09224.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF11">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00585">
        <property type="entry name" value="Thr_dehydrat_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51672">
        <property type="entry name" value="ACT_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="10 12 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="367"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="ACT-like" evidence="14">
        <location>
            <begin position="463"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU31700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU64346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="60192" checksum="27DC568F97C9A522" modified="2019-07-31" version="1">MATTATVEYSSHAPERIPSTRYPRLAPHNLLPDGHPDYLKLILTSKVYEILKETPLVYCPSLSARLGNQIWLKREDLQEVFSFKIRGAYNFMASLPEEDRWKGVVTCSAGNHAQGVALSGSRLGIPCTIVMPKATPSIKVRNVSRLGAKVVLFGQDFDEAKTECARLAQTHGLIFVPPYDDPLVIAGQGTVGMEILKQIPNPETLDGIVAGIGGGGLVAGIAEYVKRIGSPRTKVIGGETIDADAMARSLEKRERVTLDEVGLFSDGTAVKIVGEEPFRICQALLDDVVKVDTDELCAAIKDVFEETRSITEPAGALALAALKRYIVDNQLIGAQKKFVAVISGANMNFDRLRFVAERAELGEGREALLSVEIPEKPGSFVALHDMIHPRATTEFVYRYHDPERAQIFLSFQLETTSRAKEVSELVLGLDKLGMKAVDISDDEMAKSHARYMIGGCKQVPNERLFRFEFPERPDALRRFLKGLHSGWNISLFHYRNHGADIGKVLAGIQVPPADTDEFSDYLKKLGYPYVEETDNEVYKRFLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N6F0</accession>
    <name>A0A4Q9N6F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_809475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N6F0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11083" checksum="762C70344F7D42A4" modified="2019-07-31" version="1" fragment="single">VLLVLNVLHLVFTELSIISSYGLSDISIFTSHLTSVIVSNFLMDLQQSYQKNVNLDTDDPLHTSHISTLRSDTASYSLGPLGAIIGPDTYPADAELEDMTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBJ1</accession>
    <name>A0A4Q9NBJ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_887953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="TBU53323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9NBJ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
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    </dbReference>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
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        <location>
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            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
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            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="581" mass="63132" checksum="1E20E24E8EE2E4BC" modified="2019-07-31" version="1">MAPSKHRKLDIPSKSKLKKDPGVPRLPSLKARNAGKHARPPPRADPDAQMASEPTLSSLAALAASTSEVDDGAYSADPSSSRGAPKTKEQLRRHYIRALHKVIDEADIIVLVLDARDPEGCRSRLVEEEVRRREAEGKRLVFVLNKVDLVPRDNAEAWLRYLRHTTPTLPFKSASSNQRTNLSSSTAPALLRLLKAYKPSAQSITVGIVGYPNVGKSSLINSLKRSKVCAVAAQPGHTKELQTVQLERGLRIIDSPGVVFDEDDFDDRKSARKSNLLLRNVVKVEDVADPVALVEEILARTDPATIKKLYNVEDYSSPLEFLTMLALLTGRLLKGGTPDILAAARHVLMDWNHQKIPYFSLPPSVHPSLVPSTVPGTSGGQVAPGAEAVGQAQILTELSKPFQLEGLFGQADAGAFGAAAQGEGTDAEMEEDPDAFVPDVESMDEDGKQMESDDLAPRIPRKRSRSPSPSTLSIATLAPSDAPSYQSNKATRSQVTIDDNARPPAPKRLRRSHDVPDYHAPVDEHARRGMAGANPLSRKVLKKEAKKARRTANRAAQAERVRAGLGMDVDEDVVLETTFMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCU7</accession>
    <name>A0A4Q9NCU7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_870139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU63338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27350" checksum="7CF8EA70A10BFBCA" modified="2019-07-31" version="1">MPLSPSESHVVLSTVCVPGVDVTEDQLKTCAALFSQNYSVWAPSVGPPLKAGGRVRMNATKLRAQCLSNPEDSVLVLRYKEEQLVGHAFATKWACGTDIVGWITQLVVVVNERRKYIATSLLQALKDTDWFAGIAMMGVVSSQPATCHALCKMFSGLPISDINLDFIRQVAAKALKSSTVQYLRNAQLHGSLFEDATDGSISLANTEYFIDHDEPNAVLRHYIEKKQWPLGILKEGHEFAVVIPTAPLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIF2</accession>
    <name>A0A4Q9NIF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heavy metal translocatin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_817147</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIF2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056236">
        <property type="entry name" value="HMA_PCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24534">
        <property type="entry name" value="HMA_PCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00943">
        <property type="entry name" value="CUATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="522"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="670"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="714"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1026"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1081" mass="113664" checksum="B7B3032142B7E26D" modified="2019-07-31" version="1">MDKHANASCADHKDQGKTPDPGCCEGDSCGCDDTCIDELARVICADDDTHLHTRAEAGSRLSGDASIGSDCTCCDEDKEIEAEDKADGEATTQSAPPKPVQHCAHSGLRKRTTAQRPSSSSSVPKQACGEHRNMARNRYNDTLAAFGCVCKALLARGLKSCCTPPSLAGKAIAWPPSSKHSAKLTNRRTSAESSRAPSVSSCCGKSDCGGGQALSIRSLPYSGHVGSRSVRSRSCASVDSCCRDSCCGDGSDEKSEHVAIDMAEKGAGAYNEHVVLAIKGMTCTGCENKLIRTLKGIPAIHNAKTSLVLCRAEFDFDNDATDITSLAQLIEKRSGFSAEVIKAGFTRDLLINIPRSLQEQFMAAARPNGVQVAVRSGKDTLIVKYDPNLIGARDVIEAYCAFTPVLAPEPLDPSIAAGAKHIRLLSARAVLSALLTIPVLVMTWAPLPPHPHAYAIASLVLASIVQVAITGPFYISSFKSLVFSRLVETELLIVLSTTAAYVYSVVAFAFEMVGRPLATGQFFETSTLLVTLIMVGQVISAIARQRAIEAISIRSLQEKTACIVFPDKTERVLDVRLLHSGDKFKVLPDSAIITDGEVISGTSTVDESMMSGESRPVEKGPGDAVIAGTLNGPSTLVVKVTRLPGENTISEIAGMVDDARFSRARVQETVDWVCGWFVPVVLALAIVTFAVWMGVGVSVRHQSSGHAAVVALTYAISVLAISCPCAVGLAVPMVILIAGGVGAKLGLVFKSATTIEQARKVTHVVLDKTGTVTQGKLSVTSRFIDEDPGFDVLSVVAELVASSRHPVARAVAADLKLAPSAKPSVDDIEMVTGRGVQGDYRGMLLRGGSAQWVGMQSHPAVQPLLAQGLTTFCVIHGMRLVAAFGLSDALRPEAQSLIKSLNARNIRVSILSGDHPAAVSSTAAMLGIPPERVRASCLPADKQAYIKDLAAQGEIVLFCGDGTNDAVALAQAAVGVHLHTGEGAGVAASTAADVVLTHPSLVGIVTLLELSDAVARRITANFAWSAIYNLVAILLAAGAFVHARIPPAYAGLGEVVSVVPVVLVAMQLKWFKAVGTLEKYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIS1</accession>
    <name>A0A4Q9NIS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_933132</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIS1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU55716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="524" mass="59220" checksum="2F0C71CCA822E1EF" modified="2019-07-31" version="1">MEPHYLHIFAPVSFAACLLLLFRIAISWRLSRRCDRARLPPGPKAIPVLGNVHQLPQTYQERTFADWTKEFGDIVFAKIFRKPVLVLGSLRAAQDLLEKKSGNYSDRPRLILLSELMGWDNVVTHMEYGDRFRKHRRWIHDNFQTKSALQGYQPIQCRETYTLLSGLLESPVDFLAHINRWATGMIMEITYGHRIDSLEDEYVKLAHEATTATVLAGSPGSMLVDFFPILKALPTWMPGAGFKREALRIRGMVRAMMQSPYEMVTLALAAGTARPSFTASLLEETYSRNGPSAEEVDDIQGAAGVIYGAGTETTVTVLSTFILAMALHPDAFRRAQEELDRVIGKSRLPDFEDRGSLPYLDCVISEVLRWRCPVPLGIPHNAMYDDEYRGYHIPGKTMVIANMWKMTQDSTYYPEPQKFRPERWLEMDRHVAEFADPRKIVFGFGRRLCPGRDFAEASIWLAAANIISLLDITKVKDQWGTEIVPSADYASGFVSQPKPFVCSILPRCDTAADLIAQARVGLTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJW1</accession>
    <name>A0A4Q9NJW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Monocarboxylate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_946632</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJW1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="450" mass="48300" checksum="C880DF159907A470" modified="2019-07-31" version="1">MVEAEKQGHRKTEVQLGNVNPETAVVDAPATPIAEPELEYVPDGGKQAWTVVLGSTLALFASAGMINAYGTFQDYYESTLLPSSSSASISLIGSLQVFFLYAGGPLTGRIFDAYGTSVLVPLGSVLCVFAMMMVSLTEKDHAYQLFLSQGVLFGLGIALMFNPSVAVVGHWFRRRRATAIGVVLSGGAVGGIVFPILLQHLIPIVGFGWAVRVIGFIIMACFILACLTIKTRLPLSRHVSWRTAIDLHGFKDIRYVLATIAGFLLFYALFIPYFYIQIYASFRGVSPNISNYLLAILNAMNVPSRILPGMLADRFGPLECFIPASAICTILVLGLWLPSRGAGTIVAFAALYGLFSGAFVSLLATYIATITPREVYGARLGSVYIFIAVATLIGTPTAGALLNITDEEHFNSLIMFTGVLLAAGTVVLIGAAVVGSERAREKLRGRFSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJX5</accession>
    <name>A0A4Q9NJX5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_932187</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJX5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJX5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="143"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="676"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="798" mass="89970" checksum="11A1DB61198B117A" modified="2019-07-31" version="1">MSCSVLELPNEDFHRAFLASTEHFPWKQRAHEQSFTNLQDADELSEQDISERLIQAINSGCLDSGSQLSPQDSRVFSNGSENVTHAAFFRSEPTSFPPSWYDETVPVVFARHFTGGDPFDDAEYEDEYGVIQEEKDNVMRPAMRIVEHLFAAQHRVFLFMILVIGRRFRLLRWDRAGIIVETPSELCDCLWRLSLLDDAALGFDPSATRVLPGDVDYLRMDLAAMKSAHDVDHTERPLDMGDAEGSVVFEYTRTLFRSTLPPHWPRYRLEVTDNGTTHHFLVGKPVFRAGGTAGRGTRGYVALDCQTRQFVWLKDVWRAAYMVASREGDVLRKLNEAGVEQVPTLVCHGDVCDQATVTTEWWERKNASSIPSPSLQPAAAENSSSRSLSGSTSSGKRKREDDTGNNITPSRRRGRRNRKGALLSNSPLRQHKHYRVVVEQVALPLKHFRNGRQLASIVLDGIRAHHQAATNPKTRLLHRDISGGNILIYPKVKRDSNGTNPAIVWTGLLVDWELSKPIDDDQAPSKASQAEHMGTYQFMSVKVSDELESFFHVLLYYCVRYLRSNCGCPTSYIENYFESYDGPGQFHTCGWKSLAMQEDDFLSNQFPPSPLLFYSPMDEILDTILRCFQSLYKVRKDDARKARGPPPPKLLPPESSDKRLAPIHIPVIRYHGDDAKRMQAKPPAPPPVVDDSPTPEDRERAMNVHDHQFMIEHITKTLSSSEWSDDDREPPPAVKTQTSASGSHGQSASDQALQPTHVSNKRRRIAGPERNVSLPARLHASTRRTRVKPCTLPVKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NM73</accession>
    <name>A0A4Q9NM73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_953003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145276">
        <property type="protein sequence ID" value="TBU51925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NM73"/>
    <dbReference type="STRING" id="114155.A0A4Q9NM73"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9384" checksum="A2E98CED655AA1C1" modified="2019-07-31" version="1">MGAISTWCYVALQYDIDGRELPDGIPTGYVPQGTTAPALWPLNICRTETFELNVALCPRAVAFACRAKPDDAAIVQQDEHLYAGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMZ4</accession>
    <name>A0A4Q9NMZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_806494</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9NMZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041221">
        <property type="entry name" value="APC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18122">
        <property type="entry name" value="APC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="22"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="82"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="9">
        <location>
            <begin position="1421"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 C-terminal" evidence="8">
        <location>
            <begin position="1551"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1792" mass="200800" checksum="0E2AA91F6916F93B" modified="2019-07-31" version="1">MPLDIDPSERPIFGAFARARMEKKREEDREERTRGVFVFVRGQTKIYMDNGSEHTLNLPFLVRRAWPVEPHGLFIQRVVDTWELEEIKQSGQAGITTIFTLTSPFSEPAAIGLTDGIKGDYAGVPLELKPDYYSDPVSLPPDERIIWVSQHAWKLTDKLIVTLNAELNRVTIWRYVYAPPPPSSRKSNARPTTHAQHAKRSSMSGNTSAHLRQSNATTDDLHLSPGRPDTKRTSAVPGLAPTLTTTTTMEELMGGVVGGDLSKKSHWNPPFPLKTDPSGKLDLNIWRASEPVNLDDVPDPAEEKRMQSQFWAEKLHEETLPEAAIADYENISVAAFDERWDGKKTRSLLGICFRATASVLIYALERRDDLTMGVQPLTRLPALAIATVRATRDFVADLLLLKPDGKLALLVHGTFELPLSVKLPVIRHGRFIKGPNKSHVVGLANPVYSSVSLQLSDESTVRVSLDLIPRDHLVSDCLLMLSFVFPADMFFILHRTFMAEWAATGFSFIIGVEFKIFETSLLQTLGLETEGPLETHLADDPWIRLSATESFDKFQEDPVLRKLQLPGPRPAENWRKPSSKPHPLVSAALHVLHLVAEEKRVFLPSYEGLPRLTPLICRLAMIVRPEWADYWKRFCPNAMQAWPIPSATVPEYIDDRLPVWPADMSSILYGRINNPEWTLPWLESWNLHTLYGYPAAFVFGRQEPLTHLQALNRIYMALSDGKTPDIRKRAEAGLRAMEETGITPTILQNLSLGVSAPLREALRTAQLSPAGDWSVPIYQLIGRNDLAEGFSSNPAVFANSGYRSVREILHPSVPRKTCRQLIEDVHRVVSKDPTKTTGVELDTNDFTRIRFGQDRRLEEIARMLCSATIPHIRAIERPELNEAEQLREQQHQVIRMTERTLALPLGRALFTFGTIPIVTKESFAIPKFEFSVRIQPGNLLLAPEGGKIPPECLNWGEFHNGVAAGLRISAQAQSVESSWIKFNKPSELTPEHAGFLYALGLTGHLREMLTWHTFGYLTPKHDMTSIGVLLGLAAANVGTSNRHVTKLIAVHTPALLPTPDVDLNVPLITQSAGLMGIGLLYMGTKHRRMAEVCLNQISRRDLYQPDISNEYREAYTLSAALACGMVLLGKGSSIPADLVIQRRLRLLIHGEPRLVDNGRPARPTFDVNLTSPAATVTLALMYLRTERQDVADILTIPDTLEAINQIQPSFLMLRAMARAIIMWNTIQPTKAWLMGQLPSAVKAAMDARFRGKQVDDGYELAYYNLLAGSCFAIALKYAGTAREEAYLLLVQYYDMFSQLAYTNSMAYDQRIKRSAIREGLNLISVSLTMVMAGTGEINCLRRLRYAYGMYNHPIRYGCHVANHMSIGLLFLGGGRYTLGTSDAAIACLIAAFYPRFAPVSSDNKSYLQAYRHLWVLAVEPRCLVARDVDSREVVYVPVKIKIRDGKEIGNVQLIAPTLVPEVDKLVSIRVDTPRYWPFYLDIANSPRHRDCLLRSQTLFVKRRTAFLSYMEDPKGSRSLFVRSGSSTGDAATLDFPRTTDLKAHPASDLHHFIASSSNDPLFLAFADRFCKDDGETPDERRFQSYCHAALLDSIVQDKPQTLQSHLSIFHIRTMSPESAYFTMRLQDLRFAADFYSKIYDRRFSGRTENNSRPPLIRENTLLGTLHVLDVNLDAIRSTTLFQSFLAHYARGEGITGQQESSAERMASHHLSWYLQRNSVPVSTVLVVLRSLARSAHDRCIVAPPPDGTTDTDVLDQGIKELLHATGTQMSTTMGSGWTMRSLDEVIAAWSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NN01</accession>
    <name>A0A4Q9NN01_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_329380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NN01"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235">
        <property type="entry name" value="KRUEPPEL-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23235:SF120">
        <property type="entry name" value="KRUPPEL-LIKE FACTOR 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="311"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="437" mass="47239" checksum="3E6D713424C415A7" modified="2019-07-31" version="1">MPSELVDSPLTDVAPGRPTAIPSATCGALQQIVKQQTSSSSRGFGSFSDSLGLPVDDTGHEFLVQLDMWIPTIPITSESQKSEMADSAHFDVSGAPSAEYDSGRSSTNLLTPLSHAPVDFELESIESTLSEFKDAPYIVENTYAASASPSEVSRGLETIGAHLVIDGPPSFVPISSWAQPGSGQLPWQYCRPTAADVRGHSSALYYPVGSIAYPCVGAEPAMDNSWGASQAYPRAQSPHGVLSEGRVARYYCPTVAIDPTLLVPGAEHRFPGRPPLNDQEQPQEQHIDVAPAGAIGPESDMQASFNYHYLESFPESPSSPTTSDASHYPHPDPSETTKHVDKPRDTASNTPAKTKGPRRQSTEKVFPCDWPGCTKSFARSNNLKVHRDGVHLQKRDKVCPFNGCIKAKSGFSRKYDLELHIKKHHSSGSMKTKKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNA4</accession>
    <name>A0A4Q9NNA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1040961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNA4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF4">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="228" mass="25035" checksum="E95CD89C16921E77" modified="2019-07-31" version="1">MAISRAFHIPGILFLFVSFVLLFLVSIGLPFLTALDFVRVHFKNGLPTVGSDTTAINQIRLGTWAACWYETDGDRGCSAAHNAYATTIYDAQRQGFVHIAPSWTRGLAIHPVATAVTLVALVLSFSTHVTARLLASLAAFLAAFLTLVAFLCDIALYAWVKHQVGKLSNVGSNTDTAPGFWITFVCFLLLTFAGCTVCFGRRRDRLDGATTYSYSWRDRFRIGRKSAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNS4</accession>
    <name>A0A4Q9NNS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation initiation factor eIF 4e-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_929394</name>
        <name evidence="3" type="ORF">BD311DRAFT_796605</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143413">
        <property type="protein sequence ID" value="TBU29378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNS4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNS4"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF73">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 4E, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU29378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="454" mass="48478" checksum="26B409926F0DB087" modified="2019-07-31" version="1">MSTSPPPTTTTAAQDAPAKPERPSAGPRMPSLNQLAARINLNAPTPALAGSRPRLAASLLRTSSAASTTSSTAASASDSVAVNAPTSRAESPGALSVSPPHSDRSTPVGEQADPGEPLTTEKVEKHNQEVTADEKKPRQKMPVGYKNIPSLDAITARLAKARTLSVDGSAKPPEAETIEDPKTPGLRIKAPEHPLEHTWTLYHDNKTKVPFTPATATSEVAPPASAGVHYMAPDTDEYEAGLTVIGEFDTVESFCRYFNWLKPPSKLERNSNYHLFKSGIKPMWEDEANANGGKWVLTMKNNPQLLDRCWSWLAMALVGEDLDEGDEICGAVVSLRSKVDRIQLWTRTKEDVEKINGIARKMVKLLDVSETDGIGLEFQYNNDDRPVPNKFLTIQAVPQSSYRTSFHGKPPGFNSPVSGPGEGPQIGGGPGGAFAGFGVGGGGVLGSGWRGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR46</accession>
    <name>A0A4Q9NR46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HSP20-like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_969784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR46"/>
    <dbReference type="STRING" id="114155.A0A4Q9NR46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06464">
        <property type="entry name" value="ACD_sHsps-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031107">
        <property type="entry name" value="Small_HSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11527">
        <property type="entry name" value="HEAT-SHOCK PROTEIN 20 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17608" checksum="329242E673DED77A" modified="2019-07-31" version="1">MSLVNFFNNDPFFSEFDRLFDEAFARRTGGGNTQVQRQSGNDAPRVLRPRVDVHEDKEKNVVTATFELPGINKENVSIDVQDNLLTVSGETKFESNRDENGYVVRERRFGRFSRSLPVPQGVKPEEIKASMDNGVLTVTYPRQTAEQLPKRITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSD0</accession>
    <name>A0A4Q9NSD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_920849</name>
        <name evidence="7" type="ORF">BD311DRAFT_755272</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143408">
        <property type="protein sequence ID" value="TBU30085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSD0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NSD0"/>
    <dbReference type="OrthoDB" id="2801305at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041003633" description="Hydrophobin" evidence="6">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU30085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="112" mass="11114" checksum="EB19DEDBB5C766FC" modified="2019-07-31" version="1">MFSRLAAFVVVALPILAAATPLEGRNEPASSCATAPVQCCDTVEKASDPSISKELGLLGVVVQDVDALVGLTCSPITVIGVGSGSSCSANAVCCDDNSFGGLVSIGCVPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSQ8</accession>
    <name>A0A4Q9NSQ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial</fullName>
            <shortName evidence="7">Glu-AdT subunit A</shortName>
            <ecNumber evidence="7">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1010292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-glutamyl-tRNA(Gln) + L-glutamine + ATP + H2O = L-glutaminyl-tRNA(Gln) + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="7"/>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSQ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NSQ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070681">
        <property type="term" value="P:glutaminyl-tRNAGln biosynthesis via transamidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF7">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="7">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU59549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="513" mass="54288" checksum="DDB49BA20E9D0262" modified="2019-07-31" version="1">MISRSPSRFCRLHETIRPYERNVSSPARAHPTNALVGPLGTSSYPLSGAGPLVGLRLAVKDNICTKSLPTTCSSKVLQDYHSPFDATVVSLLWNNGAEIVGKANCDEFGMGSLNLYSVHGPVVNPFGLQGEESAAERRSAGGSSGGSAAAVAAGLCEAALGTDTGGSVRLPASYCGVVGMKPSYGIISRWGVVSFADSLDCVGVLARDIDTTRRVHDSLAVWDHRDPTAAPPHVRTRAKRVSESALEYLKSETLAGLRIGVPREYFPSELEQSVVAPLRSLLNQLRARGATIVPVSLPSTPYALSAYYVISSAEASSNLARYDGIEYGMRVEPPPGANFTKTANVYAYTRSQGFGREVQRRILLGTYALSADAFENYFLQAQRVRKLIKADFDRVFCIPSVLNSPSSPISAGPSEGVHVLIHPSAIRTAPALPTLDSEGNPEDGTDAPTSTLDAYVQDVMTVPASLAGLPALSIPAGTGADGWPIGASVVGQWGSDELVLKVGEIIERCRGDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVX4</accession>
    <name>A0A4Q9NVX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_822843</name>
        <name evidence="7" type="ORF">BD311DRAFT_712171</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVX4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NVX4"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU33922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="210" mass="23839" checksum="B1B95676FEDB7DE2" modified="2019-07-31" version="1">MTIYSLYIFDRHCNCVYYQDWHRTVRPKTAVEGGMLPAVYAPVYPAANPDSLYGNRNTLSSSSGVVVAVNDEQPHTPLPTQTHSPIAPLPTPPTSSLPFDEEAKLVYGVVLSLRNMIKKLSGKDEQFVNYQTSTYKLHLYETLSGFKFVMLSDPNADSLRFVLRQIYSGPFLEYVVRNPLVGMDSRERGIDNEYFRMSTDRLIRGLTVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWG0</accession>
    <name>A0A4Q9NWG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU61991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWG0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NWG0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF11">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="29074" checksum="82CC6D892D31627F" modified="2019-07-31" version="1">MPGIKDAKSVLVIGATAGIGRALALAIHNLETKPTVIVSGRRQERLDEIATQGERIRTARVDLNTHHDNLKAFVEDILSNYPDLDTILLSSGIQHIFDFKKPETIDFKVLEAELNTNYLSIIKTIILFLPHFLKRSSEGKPSFIIPITSALASAPKPDVPNYCATKAALHSFDISLRAQLKGTNVHVLEIFPPLVESELHDHQGTTPALSKHWMPLDEYTKHTLEGLIRGDPDVTAGFSVGVFEKWEKGKREQVEQATFPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1D7</accession>
    <name>A0A4Q9P1D7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_608486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1D7"/>
    <dbReference type="STRING" id="114155.A0A4Q9P1D7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000578">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU56586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="747" mass="81860" checksum="6D7D61836B5F647C" modified="2019-07-31" version="1">MPKIAALHGISNIYSKHKPPGHATPRKRAHKREHAWVDVSDDDLEVKSSKKLSSKGTNKSDHGPRKKARLSAPPGPSFKESLHQQRKQLPIYSGKDAVVDMIRENDVTVLIGETGSGKTTQVPQYLLEAGLSGSGMIAITQPRKVAATSLASRVASEQSTSVGSLVGYSVRFDEACSSDTRIKYVTDGMLVRELLGDPLLSRYSVVIVDEAHERTLRTDLLLANLKTLLRTRNAPTSAVREGAKGKGKGKGKERASEKLNPLKVVIMSATLEAEKFSKFFGGAQVVYVKGRQHPVTIYHTKTSQPDYVDAAFRTFFQIHTDRPSGDVLIFLPGQEDIESLEKSIQLYANQLPKDASGVLVCPMYAALPPSQQTKIFSPTPAGMRKCILATNIAETSITIPGVKYVIDTGKCKEKRYLAKHTGTGFDTLLTRDITQSSAVQRAGRAGREGKGFCFRLYTEEAFNALPITAEPEILRCTLTSSVLQLRCLSQNLEELDLMDTPEESSIAFALIALVLLGALDNRRSLTPLGRKMAAFPLEPPLARALLAAPELGCTSEVLAIVSVLSSSSSLFVNSHDARDAAADARRKFRHPSGDHLTILNVVRAYEDVAGAESKAGRRDWCRKMFLNERCLAEAVNIRAQLRDVCERQQIDWRVGVGDSQGAESAILRAMVQGLVQNTAFLQPDGSYKQVMGHTILKIHPSSSLVDKKVPAIIYDELVYTTHIYARGVSAIPRNFIAEVPLLKQRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1Z8</accession>
    <name>A0A4Q9P1Z8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1037600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1Z8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P1Z8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="132"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="340"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="689" mass="77999" checksum="807B302ADDE6A2E4" modified="2019-07-31" version="1">MRLLNTRTGRFEEKNPEQITYAILSHTWDEIEQTFQDVREIQRSYDEHGRLLYWRLLPEVTQRALYAGRHVGRAFIRLTSVASAYEVLRIGIRRYMRSPRQESPSLRVRPSSDGRFSGISRRTIPLLTSIWHDPRLSSKVKEACAVARENGYDYLWIDSCCIDKTSSSELSEAINSMYDWYRSAAVCYAYLSDVPFGEKHRAGSSRFRSSRWFKRGWTLQELIAPSALTFLSEDWKVIGTKGSLCDLVEDVTSIPEEALLHTKPLDLFSVAERFSWAATRQTTRTEDRAYSLLGIFAIHMPTLYGEGELAFQRLQEEVDLIKPASLRNALRISHVATEAPLGASDERYLFAPSLSKFTAGGKLRHLSHDAVFRVLQLPFLPAPKYSSTAHGIRTKLPLVPLSRCLPQFAATYPRDAPQSQWHLAILGCEHDDYPGHLLGRVCYVPPSGSGIDYLFCGFVEIGPRPTRGPHDPSLFPLSPATLKRCRKHITLRTVYIPKPAHEQAHPSMWSQGLDARFKTRPLVNAALVLLRTTRDALRAQGYLAELRGPDMTRDTSTHWLTLDHADHSITIEYQQLPPDDDGEGVDRVRTLPSPYPDTTLAVTAQLKVIRPRPLPGFSAELRAEPAPVYVSSKSRYHWLPSRMESVSFPCTAAKRVTMHLGLDKLLAPPHYALRVEISTETQAYAPRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2S0</accession>
    <name>A0A4Q9P2S0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">F-actin-capping protein subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_872795</name>
        <name evidence="7" type="ORF">BD311DRAFT_731788</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the F-actin-capping protein alpha subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143512">
        <property type="protein sequence ID" value="TBU23209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2S0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P2S0"/>
    <dbReference type="OrthoDB" id="340550at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.210:FF:000003">
        <property type="entry name" value="F-actin-capping protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.60">
        <property type="entry name" value="F-actin capping protein, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002189">
        <property type="entry name" value="CapZ_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042489">
        <property type="entry name" value="CapZ_alpha_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10653:SF0">
        <property type="entry name" value="F-ACTIN-CAPPING PROTEIN SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01267">
        <property type="entry name" value="F-actin_cap_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00191">
        <property type="entry name" value="FACTINCAPA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0117">Actin capping</keyword>
    <keyword evidence="4 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU23209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="299" mass="32984" checksum="B49F6A5B853F73A9" modified="2019-07-31" version="1">MDPAERIEAASKFLLQSPPGEINDVLNDVRNIISDDDSLQSGVLPALREYNITQFTTAEVPGHQHQSIVSSAARIPGAGEDEDGELSQDRYWDPRSRTSFRFDHLSLESSDPEPYEPDAESEPFRAALENASLQYLQAHYHDGVASVFPVAGSSTRFVIQIVANKYNPNNYWSGRWRSEYTIDTSTKTLEGRILVNVHYYEQGNVQLSTTHTVSLALPPAIAPSGGASAASKVLALVEAEEGKYQTSLNEAYAEMGEKTFKGLRRALPMTRSKLDWDRVLGYKLGAELTNSKGVFGQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P382</accession>
    <name>A0A4Q9P382_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P382"/>
    <dbReference type="STRING" id="114155.A0A4Q9P382"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="517" mass="54410" checksum="7C697E9A898C0EF6" modified="2019-07-31" version="1">MILTPAGAPPSLCSAPGEASSAVANPAQSPATVPQPQRPLLDISNSPTGRRIQGGEDSVGDTLFLETLKVPTVILETPSISHTMAAALSLSLLGHTLFLKSQVPFPIAQLSRMPGGKSNPKAAKKRDELLATFDILASHLQTTFVAISTAYAKCKSATSDENGHTRNVARPSRGTAHLMFVFGPSANAARARIVLTIDGLDVKVWGARPCDSLYRDDDDVDGEEDSDEDSQGSEEVSEEEGSDSEDDASEEDDVSDVESSGSDSGSGPPPSRSPSPLPPNRSLAPSPESLPSPFAPLTPLPEKPTPLTFAHPPPVPSILPPVAPKPQTAPRPPSPPLSTPEPSARASTTSRDASPAPAPTPELTYAEEQQTLRAAERLLSRTLMNAWVDGEGDMSSELAPTQTHLFLRAPRRFAHPAWAARQNLTRALDGVLASFLEDAGALPVPPAARPKSKSKGVRTEGAWIGCRGGSAYAAKAQISSSVGYGADAEDSTLGGADEEDEEIWWAWEGKIVGFADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6Y7</accession>
    <name>A0A4Q9P6Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_6562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6Y7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13863" checksum="F3EDBF9708EDBF5C" modified="2019-07-31" version="1">MPIARARVPSGRTLLTGVGVGAHCPRSGRTERLVHHRDPSAASAEESAASRLPRRTRSRDARGFPCTFGPVELLGRGSNWRSESEERRVVGTRFVSGHGRARRRQKGTVDKGGMTETDTSTGRENVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAQ0</accession>
    <name>A0A4Q9PAQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_833609</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145287">
        <property type="protein sequence ID" value="TBU51769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11256" checksum="D7DB8F7547FE1CCF" modified="2019-07-31" version="1" fragment="single">AYTHEACFSHNERLDNRTALVDPASSLVRQGKKPIAYQTTTVRPDEPRHSPGPEAHGRRSCSEVPVADGDNWAVKFGPVTMQERSGTRGDLGDAGRSCGHPDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAW4</accession>
    <name>A0A4Q9PAW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145283">
        <property type="protein sequence ID" value="TBU51824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAW4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="218" mass="24538" checksum="718C121CCE4FBAF4" modified="2019-07-31" version="1">MSRWESRRLFIPGRYPLSEERMFGAASRTGDPRATQINSAQAPLEYGVRRRFCPSQVGCSFCVANSDVTCRRRLGHTLSIGSHLWRQQPHWYVRLTSQACHRTILSTRASGYGMCPPSRGVKTLSCSRETASTAMLPIARVPETHTTWPSRRQADRARDPTSSSFDTRVAFQCEDFEAGPSSHANCLPWPLESLSRRRSRHRRLAFFSTTSIGTLSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAW9</accession>
    <name>A0A4Q9PAW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_656400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAW9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="247" mass="27578" checksum="621794EA350723AD" modified="2019-07-31" version="1">MDDSIDSRSDTTSGPSAMSLALPWEVIERIVDHSFGFTATLCSFTLTCRQLYPRSMHNLYGHVTLESRDKLFALCNVLQAKPKLQILVRAVAVPLEEFSPVPLLSILPRLYRVTFPDGNRYHDLSSDVAIHNSTLLFCHLYGSGIRSLTIEFVRFSTCSAFLRLLSAFVSIEDLTCRNIAVGLGIDADSQLVRVQHRLSRQLRLRALTVRRTMVLSALAAVFLTRRGFISHRLAGARIGGWLAPCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB17</accession>
    <name>A0A4Q9PB17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline-specific peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_941366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145279">
        <property type="protein sequence ID" value="TBU51889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB17"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005945">
        <property type="entry name" value="Pro_imino_pep"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01250">
        <property type="entry name" value="pro_imino_pep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005539">
        <property type="entry name" value="Pept_S33_TRI_F1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="33"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="303" mass="34030" checksum="5A46D9E7A62CED43" modified="2019-07-31" version="1">MEGYLHFTLPSLTTTCKTWYKVFGDLQSPTRRPLVVIHGGPGVVHNYLLSLADLVSTHGIPIVLYDQIGNGNSTHFSEKKGDTLFWTEELFLSQLRDLLEQLGIRDNFDLLGHSWGGMLGARFATSRPSGLKRLVIASAPATMKLWVEAANSLRAQLPLDVQAILDKHEADGTTETKEYQDAVGIYYSRHLCRLDPMPKDVTDVFAALQSDQTVYLTMLGPSEFTVTGSLKNWSILEDISKIEVPTLLLNSVHDEAQDAVIAPYFHSLRKVKWFTFAKSSHMPQYEEREKYMHLVGAFLTDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBL7</accession>
    <name>A0A4Q9PBL7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBL7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21741" checksum="49D2A5110291423D" modified="2019-07-31" version="1">MAAKIYSPGQDLQSIALLFPHVDQDVIASIVGHEFSGAELYKLDSRRILESTWHLIEVNMDESTISLHSAPAATETYPTLDSLLVPLNAYFSVLSMHELSGGQSPMLPYYFFRYSSHLVKIAAQYEWSAVLSYHLASFSRRCKEMRKGDFAGWGRVDMDLMEEFLVPNQKKRYGTVHAFSSGYQSWELIYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD11</accession>
    <name>A0A4Q9PD11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_941298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145276">
        <property type="protein sequence ID" value="TBU51935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD11"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="139" mass="14834" checksum="717BA23709E99DAD" modified="2019-07-31" version="1">MRARAHPTSSIPTPSSNPPNVLAPASRTRTQAVLLATVAAQGKDAIALPNRLAFLILATLAARQPRGARRSPAARHARATGPLHASRPGSRGRMIRGPQRGRDPRPVLSQTRTSQSRLAPPGRPRRTRGVCGKLLLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDD5</accession>
    <name>A0A4Q9PDD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_835490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145429">
        <property type="protein sequence ID" value="TBU51042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDD5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054722">
        <property type="entry name" value="PolX-like_BBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22936">
        <property type="entry name" value="Pol_BBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retrovirus-related Pol polyprotein from transposon TNT 1-94-like beta-barrel" evidence="1">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7218" checksum="72AD8AA53DBF1CC5" modified="2019-07-31" version="1" fragment="single">MLAEEPVARDRTILFDSGATRHMSPHRDLFISYEAITPKAVQAADDHTFRGVGRGDMYITVPNGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDW1</accession>
    <name>A0A4Q9PDW1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_953278</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145323">
        <property type="protein sequence ID" value="TBU51427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDW1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="234" mass="24591" checksum="5E2A0D665039D37E" modified="2019-07-31" version="1">MPHIDPISVVSKLDVLLKEDPDPSIEMAEIWAESLGDDVFPEHILTYAFLRRASSRQGSIDEKWVAGPSADIHTPSLALAAPDILASGSSSGPSDYQSVQGSPSSPCQSPLPSLPLHHPSGDSTGHLTPAMNPSSLLLIPKVEEATLEGASNEAGSLSQTVRLSGPVRPSGRAASHATSPPQQLVILPEELAQGLRAAPLDSVSRDDSEIPKTFADFTRWLQQLNASAGIGTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDZ8</accession>
    <name>A0A4Q9PDZ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_834282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145318">
        <property type="protein sequence ID" value="TBU51467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDZ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020364227" evidence="1">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="23601" checksum="E0A54E1A8282400C" modified="2019-07-31" version="1">MSRALILSFIFLSIFRAFPISASPVSLFLPLKLAPGVPMSATIIGTDGSGHTTWVLKEGAASGTFTKTGVAESALATAPVTLVEGSTDAHMFGAFGSQTLSVDCALQTGASGTGAPMAVCTEFAAAPSATVSGIVFTQAAAKVEVQMKTNGAGSIRMGITGVAVSVLTVLGGAGLDQRTRLSAERGPRHDLDHATTVATADSSVILFSSWVENYVSVTKNRACSAPEIMASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PET1</accession>
    <name>A0A4Q9PET1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_938527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145220">
        <property type="protein sequence ID" value="TBU53248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PET1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="10019" checksum="DC79124E007B7A4A" modified="2019-07-31" version="1">MHSPVLRQTRLAPRIGYEGSSYNICIVLGRVYMVRAYQSIWERMSESLGVRRRGMSVVMMNLIGYVEAVWLWIDPHYDSHLYPKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEY4</accession>
    <name>A0A4Q9PEY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_941572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145285">
        <property type="protein sequence ID" value="TBU51787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEY4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEY4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045341">
        <property type="entry name" value="DUF6532"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20149">
        <property type="entry name" value="DUF6532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="513" mass="56580" checksum="B12B7B5FB3D70204" modified="2019-07-31" version="1">MPKRKPVESDSPTEEDEEEMIFSDGESTSTALKRTRKVSTKQQAINNEKAAKANVELEKYKKLYHAASKKLKKQRKAKQDDADAIDDDPDRLPPESEEEDEPPAISLRASIRRQASTPTRTAVTPRIRRREGTGVVTGNATPQTMQSTLQESSLSTEPAELFALPSLTSSESAEPASLSRISSIQGQSLTSMAIGGREGSSEVDTVEPADTTPADGSSLILAPFRPGIVLGSRPNASDYTDEVKDLLQESITRYYYLYICTENAFPDSVEQRTFAKRAWKAACAARKVPVPWALSDRMIRLIGGRKSNIRGDISDAIRDRTAVAYGITEHASLSAERRNMSLVTNLMTDGIFHHKTYDFETGTRAHMFQNKFIGQAIQIAFFGSSRTGLGFLAPDTFNPIPIPTIAFVTTVIHAHLLEWSTGRRLHESFSESRHGTHYKAFKSDLESYASGNNGPIFSNIRMRMYEKAFRGGGGIALDTHTVRVTNAAMEIAKAELEARTGLTDSEDELEQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFI4</accession>
    <name>A0A4Q9PFI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_833282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145276">
        <property type="protein sequence ID" value="TBU51937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFI4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8477" checksum="83428B0CCB8EB67F" modified="2019-07-31" version="1">MFPSNIHVIQDCPVTGGEQALARTTGSDDDHAPTSQKRSLGLIHHGIMRATRLVRAQPPGNWPPAPQARRASLSDMGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFV6</accession>
    <name>A0A4Q9PFV6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_129628</name>
        <name evidence="3" type="ORF">BD311DRAFT_754994</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143407">
        <property type="protein sequence ID" value="TBU30228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU53758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFV6"/>
    <dbReference type="OMA" id="QPMWTAI"/>
    <dbReference type="OrthoDB" id="112668at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="6"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU30228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9530" checksum="932831D2365353E5" modified="2019-07-31" version="1">MAESFHWRMQLNNYLQANGGARLLTWDVYQSGPLHQPSWTAIAYIRGVEYGRAYGSSQAAVKEEAARQTLEALIQDRRSRSYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG01</accession>
    <name>A0A4Q9PG01_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphatidate cytidylyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_832932</name>
        <name evidence="3" type="ORF">BD311DRAFT_782644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143567">
        <property type="protein sequence ID" value="TBU21924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145267">
        <property type="protein sequence ID" value="TBU52087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG01"/>
    <dbReference type="STRING" id="114155.A0A4Q9PG01"/>
    <dbReference type="OMA" id="NYWREMS"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU21924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="36591" checksum="3720E9D00E85F303" modified="2019-07-31" version="1">MSVDSPESPPSPDSRNLPSHSAVSSVRNGVPNGAPLRQRKKARTASATSPDLATKPKDLKPSRPPVDWEIPRKTLHSSIGFLTWYLYASNGNPRTVVYALGLALAVIVPADILRFKSDRFEWLYERAVGFLMRESEKKAVNGVIWYILGVIFVLSVYPLDIATVSILILSWADTAASTIGRLWGTYTPPLPRSLPLIPYAPFFRLPLAPRKSLAGFLAGSITGAAIAVGFWGFWYPVRDAQLVFHLPTPETLAAVNDLMPEAAAHALQESVQWLQNVDIPLGRWIGLTTLGVVSGLISGTAEALDLGALDDNLTLPIISGGCIWGFFKVLEFFTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG44</accession>
    <name>A0A4Q9PG44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ctf8-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_275378</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CTF8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145276">
        <property type="protein sequence ID" value="TBU51931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG44"/>
    <dbReference type="STRING" id="114155.A0A4Q9PG44"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018607">
        <property type="entry name" value="Ctf8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605:SF1">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28605">
        <property type="entry name" value="CTF8, CHROMOSOME TRANSMISSION FIDELITY FACTOR 8 HOMOLOG (S. CEREVISIAE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09696">
        <property type="entry name" value="Ctf8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16780" checksum="40C2E9DDD7F244DB" modified="2019-07-31" version="1">MLIPINIDLPGPSTPRRPNLPPQLIQFGTDELILIELQGSLEVEGNRDGQLVGKLRVDAVTKPTLVIGHHLLEGKMVSLNKPLAVLHRHDARASHDGADEDASMDVDGPLKGGEAKSWDMIAIVKRKMVFSKRPMPIASSTKGITTPLSRIGSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGG8</accession>
    <name>A0A4Q9PGG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145262">
        <property type="protein sequence ID" value="TBU52181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9921" checksum="A58812DAFE4AA9EF" modified="2019-07-31" version="1">MSLHRPSALLAIAPLPNLEPRQTLLFLPPNDRAIECDRITYGLRKRRLSFHNVVRVQQRSQQQLERHSVVSIGLQGVSPWLIPGPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI78</accession>
    <name>A0A4Q9PI78_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_937165</name>
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    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI78"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6922" checksum="525661375E3D526C" modified="2019-07-31" version="1">MSHMSTVSLQTHVIVPVANCSVLQALLCSSNLPTSSVPPSYSATTGIMEVQITHKVMVSGAPRRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ69</accession>
    <name>A0A4Q9PJ69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ69"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13534" checksum="691A02E0FA183169" modified="2019-07-31" version="1">MRAGHNAHFLFRAVAPAGVGSVLFLTTSHPGFRVFFIRPTITPSAVGLLFSRLFNRTLQGLLDKCELRNEPIKYMGKHLASGASIGTIHRRGSSNANVGDSSDDLMTLFSCSTASTNIPCAFFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJX0</accession>
    <name>A0A4Q9PJX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_951495</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="23"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16273" checksum="CEC1B9326ECC7181" modified="2019-07-31" version="1">MVSDSAEVQAAITAASAQTLVNYIGVAALVLFAYDYLITLHSEVVLFWMPRRFNGASILFALNRYLTMMVQILGIVPLPSSFQVPVSDSTAFLVLGPLQYLSWAAFSALRTYALCATRYRLVISIAVFALSSVPLIINMIVHRDPCTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKD0</accession>
    <name>A0A4Q9PKD0_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKD0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7434" checksum="8836B4A146D4DEF0" modified="2019-07-31" version="1" fragment="single">MDYVLRETARNLIESHNHIPHDICDDVKPLREKDIVFGGCRLPNIMCLPTMSGEIHSEAYRLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKH9</accession>
    <name>A0A4Q9PKH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_935241</name>
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    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5944" checksum="964C6AAAA6BE4060" modified="2019-07-31" version="1" fragment="single">MPRYTGFSAFRRSTSPLLNIVNKSKVAVIHNRLYWCCEGVKAVEPNLRPSHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMZ3</accession>
    <name>A0A4Q9PMZ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_682851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PMZ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14003">
        <property type="entry name" value="STKc_AMPK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="333"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1196"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="408"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="647"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="838"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="906"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1196"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1293" mass="140481" checksum="AAB529E34ABB79B0" modified="2019-07-31" version="1">MAAGPNGGHKPSGSVSQAQNHKAQLASAYNELGKELSSQKIRVVGNYTLGKVIGEGTYGKVRMGTHRLTGTRVAIKQIPKAMSAALTREIHHHRQLHHPHVTQLYEVIATESSIWLITELCSGGELFDYLAEKGRLNEDEARVLFGQLCLAVAYVHEKGIVHRDLKLENVLLDERCRVKLGDFGFTREFEKGSLLETFCGTTGYAAPEMLLAKKYLGPEVDVWSLGVILYTLLTGTLPFDDDDESVMREKVIRGVYDDPEWLSDDARGLLSSILQVEPTKRLTIAQILTHSWFTTIHKNSNRDSVQSAAPTISRPASPTQLQITTAIEAQPLSASTTSDSTFHTASSEFGPSTPATPDNKSVDELTSDSHSTYKKLTGNLPSPPSSNKGTPETVREEDESAERSVETPSRPSFSRADSSSSKQPPAFPTRTPARTKRRSVSSTLSDHGPTVFEKSAVPLPPQDFSSLLHTPAPLIFSTPLERELLNSMSALGLDTGQIVHSVLTDACDCTGALWWMLKRKAERKAIEDAAKKPAEHPVEVPEEVPTELPAPLGDKKQTEREKEREKEEEKEREKRHEARRDKSYGRSSQHRSHTDEGQPSSVGRSRDSRLPIPPALLPAQSAPELQFIPATPTVAQTKRPVTPPRTASPTHPLLSPTPSSTVESLSKSNPTTPSSSKDKENQGSKGRKNRAGSVSIMQRATTALEAAGLVRKKSAEAVREERERREREDKEKQAAKSVANSEEPRSSHGSGSTKLIMTPPMRAVKDSALSSTPPPADLNGGQAQVGSPWVLAGKQSPPPDTGSPADTLTSLPQIPTRGSKVGSGHRNRASLLSTFQRWFREDPKGKRKEDPATLLALTQTSSINSAGSSPVSQRPNGRGTIKGRPAGRGKTVGGGRNKASHRAKRASVSSRRSSSVNSRRSSTSMQYPVVESPPYSATRHRSDPNRRSFGSHTPNSEREEFMSRPSSIHSFINHPRHRKSPSASSAGSMYVGRTASPLPKNHRRGGSGSSTRVVRQIQMMPSGNGGGRQQPNSHLRSNSASSVHSLQSSRPGSLYDLSETDSRRNSSPNKAAMRRSLEDTPRRGHAAFVAHKRQAPFQNPNRSEYLNSLGRSSWKKSWGLEPPGWQTRTAHPTVEVLAIYPPEVPGIRDVFSGRHSLGDESDWIDEDEESPLYVGGLGQMPSSASSVITTFGQSEAPLLSPPLRSAPARTGGGSSNNKRAAPEVGRLTVGNVPSRAARNKANRSPAGRSSPLPAESVFEANVAETRGGRRQLPNGRAGPAFRGIQEEDEDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNC9</accession>
    <name>A0A4Q9PNC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_933059</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNC9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNC9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041588">
        <property type="entry name" value="Integrase_H2C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17921">
        <property type="entry name" value="Integrase_H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase zinc-binding" evidence="2">
        <location>
            <begin position="242"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="526" mass="56714" checksum="8A368927F12CF49B" modified="2019-07-31" version="1">MPPRSARPSGTKPRGKAAVSNQADTTEPNKGKNKVAKGKRPYPASRPLRDSDNLNKKGVFASTPDAPSGGGMALKYATLPVPPRISKISSSSSSAKSDRSYPDLGMPTREEFSTMQEQYIGSLDGRKQAKALISQEMFDDIWLALHKPRDNKIGSPQFRWWVRKMFRLALPDDFGGLTPYVIDPDDDTAGNEVMAFVQYKPEGEARGNATWETSGTPRALNLNRPLPVVLHDGKRVAIREQIYDIMCACHERVGHGGRDKTANEIRKTYTWVPKDLIALFVKNCPTCVCKRTRQIDDRVEDAAPPQQTNATPTDTLLSEDTTLTNPTLQYVSLPMNDLMGGPLTTFAASPGWSLAQSSSGAGLDTFMGAGASVADISSQWRLPPQSGLAPGSGYFYLPNGMYAASLPPQFDSLELPSIRVTDADVGGAQANPHQKVTLPSLSQVLSGELTAAGRGHARVRQPLQALSGNFHPGFQQSQFSSVPGYAYPSGPPSAVPYVPIIDPLLLRQDGVHMLALAADASQSGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNG1</accession>
    <name>A0A4Q9PNG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Signal peptide peptidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_824962</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNG1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNG1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.100">
        <property type="entry name" value="Presenilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042524">
        <property type="entry name" value="Presenilin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="342"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="408" mass="45075" checksum="E7741A7DF3CF9B42" modified="2019-07-31" version="1">MSVASTDWDLLSSYAGLLSLACASIYAGSYGSLSSKSFKRPGTEPDEEDEQEVERLSSQDAYLFPVFGSVVLFGLYLIVKYYGKEWITWLLQWYFTIAGVGSVGKSLISLTRWLVGESRWKKFDNNKILVLKGPRELLSFSLRTPSLFLLPIGAIPSILYTFGGSVTRRSALLTDILGLSFSHNALSLLKLDSFKTGVVLLSGLFVYDIWWVFGTEVMVKVATNLDVPIKLLWPKSVLFSAERGFTMLGLGDIVIPGMFVATALRYDYHRASRQGQLASVRKAYFHAALVAYALGLVATMSVMHFFRKAQPALLYLSPACILSFFVMALFQGDLNEAWGWSDQVEEKPEQRSDKSAAGSVDKNAPVDAAAKSPVGDEPLSEDATALSSLPEESAEGSERKKQWEKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP13</accession>
    <name>A0A4Q9PP13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">614/534 cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_968918</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP13"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020409037" evidence="11">
        <location>
            <begin position="28"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="520" mass="58732" checksum="96844FCD3E998A12" modified="2019-07-31" version="1">MLGIDNSQALLLLTILLLSWLVQKVVAFQRVARSVDNWPGFRTVFSDRTVLFPFSVRGLSPGPAWTINSKYAEFARHGWDVITGISIYPTPQLYIADPTLTKEIMGARARFPKPTSSYALLATFGTNILVTEGDEWKRQRKIAAPAFSEKNNRLVWDETAKVLDDVFQNVWGDRDVVELDNIMDLTVPVTLLVIGVAGFGRRMSWSEDQVAPSGHSMTFKDAMYEVSHHLVLKVLFPDWLLRWGTPAMRHFATAHDELMAYLHEMVVARRAAEVKDERFDLMSNLLDANEDETDSAAKLSDSALIGNVFLFLVAGYETTAHTLAFAFTLLALHQDEQEAFYQNLKSVLPTDREPTYEDFSSLSYSLAVMNETLRLFPPVLAIPKESAEDTAFTLTSHTGETRTLPVPAQTYIALCVASMHRNPRFWPEPDAFRPARFLGAYNRDAFQPFSGGPRGCIGRGFGETEGVAVLTKIVARYKVEVREEPGWEGETFERRKERLLRCGHSLTIFPERAPLVFRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQL3</accession>
    <name>A0A4Q9PQL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQL3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="12070" checksum="139F2353CF884754" modified="2019-07-31" version="1" fragment="single">MVVWSLFWAVVSVYMHVLSYLSWLYATCSDHSSRDFLTTTKSMYEVRCKTASMRIDGPRWTCDITSSVGFPYLRYDVAVIAIIICIFVVTSILGIWDNELKYMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS15</accession>
    <name>A0A4Q9PS15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_978328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS15"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="723" mass="80152" checksum="B3C18893C66855E8" modified="2019-07-31" version="1">MPKDTAGKNKTGKIRDRRQHVEPPVVVPSAKPKGPRGNQAPVVTPLPASPSTQKRPRSSQDEGPTRKKTKHAQAGSDSVGTRPNSVRQRHLGALPSDPGALGARQPSPPPSILPPSIPTSRRARDGQHPLSSRPPPSSDPVSSSLPPSSSTSITSTLQTQEMFAATIRRMRAAPQAQMDDGEELLTDEDAPRKKGKRIQLSAQAEEEGEDVAEEEEDAEDAADTGNEVDTEDESEDEHADEEVSASDARRFLKAIRKSKKKNKYHVSPTDADPKLLTEHFKTWGRHCHRLCGLYTDVHKTIVTGMTVMRAAPHDADDYELCYKSIPHMSPATAKFYTSKFFHLCDHIPKFTALCEQILSSPENVFLFAKYMQVHAAAGRTTDISTLKTSYHSYFPYVIIAGGDVIPPPGPGTLSDLKTRNGGYCSTSTGRLVVPIDELAQFDLDPSKFCKQKISQNRKIQGASSAMRHKKRHQADRLRTRDDNMSYPSFLFPTDIKYDNTHPDRHIFKGNLLLSGPSAVGRSGGLRGFGRAPLVEIYSITKVTPDYIVYVASLLRYLLSTDDRWNGDDRQRSGHCFHTALHRLLTIEYEAWQDDIEDEYVEPSEDPLDWNVFAFYNDKVFGNEAGAPDQQDPAADVYEEDCNDADNVRAQVLKARMAELLARRAQRATRLRGASPQRDDTRSRSSSAELVDTNTHFIDITEDASPPAEDPSEHDTADDAQIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSC9</accession>
    <name>A0A4Q9PSC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_555416</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSC9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="25"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="578" mass="65176" checksum="338C27021D8E8667" modified="2019-07-31" version="1">MRFKSDTQKLGSLGHPPYLKRLASIHDLPNELLSEIFALAASQPFDTQFWGPESSKVSLIVVDNLVPISATCRAWRTLVSETPFLWSSFFLDENWNENEGALVLQRSRDVPATLYYSGGIQETLCYFLGVLRHRLRELYILDETLEWDSVASMLSTDFPMLSACTLHLGDRADETRPSRNTYLSGSLQRLCCLRLSCPVILPSGHIPHLTNLQVDGGGPHTLSSVFALLSAAPRLEYLWLVLSVERDRDQYAGIMVRLQHLKRCSLNMEPYDDFLSGLTLPPNCLVLFKDLLDFELGLEPEELPLIPTLVAALPRHPFTQCLSRLRIVPDNVGFGSTPDPEYAYHVQLANETSTSGLHFQILRGDLSGPILQPVERGKMSRTMAEEIFSAYPSGSLVANVKELWVYKWTDWLTADVLARLPLLETLVLVLDGDPWNTKWNDDPPTTIPKALTKQPKAGQAPLCPALTNLCLIMCYDHAVQETKRFVKARKRAGHPIKRLALECVNAYALEYATNGKLAKLVNELVVSSTGDNYKYWAPHTFEEGWARGLGGWPEWPEWLEWRKLNSDIMQGLDEIEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSI8</accession>
    <name>A0A4Q9PSI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SGNH hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSI8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PSI8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26011" checksum="51C0CF14BF08AFB3" modified="2019-07-31" version="1">MGRSKNERHPQSTSPVTLLWRKAEVAQELTGWGQYLGYSLNIPVVNDAVAGRSARSYTEEGRFQTLVDTVKSGDFVVIEFGHNDGGSLSTTDNGRTDCPGDGEQTCTSPTTGETVYTFVFYEVEAGKALQAKGANVIFSSQTPDNPWESGTFEYTPSRFVGYAQKAASTIGAAYVDHGQYVANRFQSLGLSTVDSFYPNDHTHTSPQGANIVSAAFVKGVLCANDVLAAHVKNTTSSVPGSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PST0</accession>
    <name>A0A4Q9PST0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_929176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PST0"/>
    <dbReference type="OMA" id="HECPCHE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="391" mass="42090" checksum="C2C7792C1BA9EE12" modified="2019-07-31" version="1">MSANVSVAPGRLSLEVNHGALNVTLFFATDLPYVALELGLSTVLFGILTTLFLVAVFFLAGNGLRRTSVRVLLLSTLLLYMSTTLWIATKGWYITSVGRAVSSARGGLYSDADIGGDVAVLSRKVSTQSLIMTMALGLNVVLGDSIVWWRACAVWRNRLVYYGGALLIALTVGFGTVAIALGDHECPCHECPCLFPNYLFQDGAFSKVSAVLSLSTNIFATALIAYKAWQHRRVLRGRTGERAARVARALILLIESGTIYCILLILLVLYEIGPAKPNTPLHAHQNMLLRAESYYTFGCFVPIVAIYPMLIIVLVALNCSPIDNGMSGMSQGGTATAAATESGDAMISNIAFGSQIRPSSSEIVEDIPMFPVKGHRKMRDGKSLQDVCAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTH6</accession>
    <name>A0A4Q9PTH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_959381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTH6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13488" checksum="DDF2C7DDD7FC5933" modified="2019-07-31" version="1">MFCMPNPRRHGWQACMVWTGAPTRYLKSTLRRRRPSVANTGTILNFVLSYGFKLTSPSCKRDFGHMVVVPCLRLVTACSGVRVGHWSLSTLLMDPRMKTSRRQPCRSRMLLRTLTCSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTM8</accession>
    <name>A0A4Q9PTM8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_820989</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTM8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="2"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU57780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="293" mass="33312" checksum="B58E30490F2F6F1F" modified="2019-07-31" version="1" fragment="single">DFRPLRVLGKGGHGTVYLVEDTVSERPFALKVVEKNGLRLREYPPVFEEQAVMQALTTGTGSGAGETSPWFVPLAGSFEDSDNFYFLTEYYPRGDLMMEMKRNGIVREHQARLWCAELLVAIEYLHKQRIIHRDIKLDNILLDEDKHIVLTDFGIARAFGRANANRPGLDVDETHSLVGTPGYVAPEVYSGTYSYGVDVWGAGVVLYCMLTGRLPFGLQPREQRLEEVIARTDSLPADLDLCGLVNEDVRDLLTKTLEKDPKKRPSIRKLKKHRWFRGMWVLERPPHLSRSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU09</accession>
    <name>A0A4Q9PU09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_906802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PU09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1295"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1759"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2131"/>
            <end position="2173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="704"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="758"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="908"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="963"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="974"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1167"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1265"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1340"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1768"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1821"/>
            <end position="1830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1831"/>
            <end position="1844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1859"/>
            <end position="1871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1872"/>
            <end position="1882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1887"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1924"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1965"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2004"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2068"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2087"/>
            <end position="2100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2158"/>
            <end position="2167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2173" mass="235033" checksum="5040748F757FF1D2" modified="2019-07-31" version="1">MKPASGTRKPYIGNTRSLVLALDVGTTFSGVSYAILEPGEIPKIHGVTRFPGQEHVAGNSKIPSIMYYDQDGIMKAAGAEAESAAIVALAEDEGWTKAELFKLRLRPKTMKLKMNGMRLAPLPTGKTAVDVFGDFLSYLFHCTRSFIIDTHANGHQLWRAVEHDIQFVLSHPNGWEGAQQAKMRRAAVYGGLIPDTDEGRARIRFVTEGEASLHACVLNGLAADVLSVSKVFRLGLSLLLLRCGAGILSLSLAQNPSGHGFIVADAGGGTLDISSYAIRGTSPLVIEEIAPPDCVFAGSVFVSRRAREFLAGKLRDSRYGTPDSLDHITKRFDETTKRLFRDSKDMQFVPFGSPLDKDLSVGIRGGQLKLLGTEVAALFEPSIEAAVLSIKRQIDSSGGTVKSVWLVGGFAASPWLFVQLQERLHKYHVVVSRPDTQTSKAVADGAIGFYCDHHVSARVSKFMYGVEYLREFDPKDEEHAARKHRLFEMPSGPRLLPDAFDCILARGVKVKESNVFSRKYCTEVTNLSTLSVFEVEIWCYRGGDTIPKWIHRSHEDFSTLCYVRADLSPLAGSAQAKQGRGGKTYWTIVFSIEIHFGLTEFKARIKWVDNGKTRYGPASIVYNEGGTRAEEDEPDSSPEDNVTVLSSPSDRGPSRSVSQPPSRDPSMRSGRPSVQASPRLPMQPPMDPPVLSRGFEPPQHHRSVSTSSSSAPRSVERHRTTSSTRSREIYGPSGAETPRSGPPMAEPMRYEDRSINVSGRSAESGRSGSTRLAEALNANWGASAPSVSSPLAENPPYNGYSQQPSRRETKPPTPVQQSPPVHSKQPTPPTMSSLQTPVITPPPLGPQEPPVPRPPSELSYATPTPSKPPSPPPVAAALPPVTPPKASPATSKIPTPTSASKAATPWGSKAATPAASKAATPSWGSKAATPAGGSKAATPAWGSKIPTPATQSKAATPRAMSKAATPKAATPRAVTPPPAEPEPEPEPAPAPAEPEPAPAWEPEPAPVAEPEPAPAPPAFVDSAPGQTSALFGDVPPVIHPSEHGDEAGSVIPPFPGAGGDEEMMPGGMGGDGPNPAATMSPMADLWSTPVPDPETNAAPQTSAGLFSDFLSGPTWAKPASKLTSSFGFGSFGGGGNGNNNSGGSGGGGFGSFGGFGWGSNDNAAAEEETRKREEKDWQHIEAEEAERKRLEEEAARQAAEEEQRKKEEEAANKPKKKLNKREQAAAKRAEEEKARKAAEEAEETARKAEEEAAEAARKAEEEAEIALQATQEAAAAAAAATTPADVIAAADLATEAQHARDQAAEAIQEAKNDAAEAEQKEEAAAEAQQEADQAEKVAEQAEQPAEQAEETAAAGEEGPNNGVEVAQAGDDDAWGDLPPVKVKKGKKGVASAAATPDAISRQASEAPDGFTAAGSGKKGKKGKKGNVRGHAQGTGDASVWLHVIEVALGAGENTITLAGRFSERILESTMMRDSHSTLRSSSADPNEAMVASQQKHIADLVARNKTLEHTTTKLRAAVAEEKDRAADAVAQIRQQWETERKEWREGCDSLQAAHRIAHLRTATEVDREHAAVLEMKEALRRERVARVHRDYKIVLFQTRELELEERVAQLERELEAAHEAKEDAVGDLEEEWQEKAAVLEARCAELAEQLKEAAAEQARAVKEKEKAEADLTTLRGEHTSIKIASERTAKNLERAELQLEALKTSHAALEKKYAESEANVASLRQQVEKWAALDKRENAEVETLRKSRIDLEVKVKQLETEKEDAEQERDKETARAEKLQRRVDKYKEAWEAHQKETEAAQEDAERLQNDLTAEEERSKNLKTQLQTCKQQLDELQSKLEDAQRRAKSGSPSKPKSTKPSKEPPSSRRAEPEPTDDDAELVEDPAPKKRPAPRPVAKAKHSSPPLAQDDDDEIMEIDPPPPPNPKEKDKEKDKEKGKGRARPELAEEEEGDSTPPITKPKPRPKSAKDREQAKEKAKERERKKPAPADDSDSDIQIVETSKPAPADKKDKRKADSVEVDDEPPPKKKRGRKKAASDHEDEDEEPSQQPPPKRRGRPPKASLGEASKGTTAKSKNVKTVKATTAATRKGKDKDKDKDKDKDDADEVDEAEVVAPKKKRKINLFPQAQQETFQWKSTEGDGGLDIPTVLSPVKEGEVTQPRPSFSTSFGSLARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVB8</accession>
    <name>A0A4Q9PVB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_926886</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVB8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU58572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="594" mass="66817" checksum="42F61805DE880FBE" modified="2019-07-31" version="1">MRRRRGYPSPCASPCSPSIRAGTSTRTCTYRRTNEIPRGVSLPQAPSTGEQPSICRPIPPSGLRHPLPVASPIFDPLRNSSVMAATAFLLVVSVIALSVITLVFPDLFGNLTGPPLPPGPRPKLLAGNVHQVPRVEPWKTYADWAKKYGQIFLLRVFGQKIIVLNSHSAVADLLESRTSIYSDRPRVWMYKELIGRKLAVFSISSENPRFRIYRKLLKSGLSSRANQEYLPLLYRETKTLLRNLKEYPDQFISHARRNAAAIILEIAYGWQVNSNDDYFVSLMEESFKLHAEIVRPGRWLVDAYPILRFVPSWFPGGGFHKQAEIYRGQFARIDQIPHAWAKEQLHSGTYTPSFTSRYMLKEDGSAPSDEEEDIIKWTSSALYVGGADTTVSVLTSFFLLMALHPESQKRAQDEIQRVVGMSRLPTADDSDRLPYVRALILEILRWCPVAPLGLPHSVTRDDVYDGYRIPKGATVYANIWALSRDPEVYPNPSTFDPERFLPAPNGTLTQMDPRKFVFGFGARVCPGAQFAELSLFVSIARILGTFDVAKPVDEHGREVEPKVEFTTTVTSHPKPFECRITPRAQALEQGVFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXL6</accession>
    <name>A0A4Q9PXL6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_976652</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXL6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXL6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="270" mass="28890" checksum="B750830E2ABD2FDF" modified="2019-07-31" version="1">MAACAVCQGRGLSIDPWEEFSASCYPLYMQQFPSPIPNYTAVPGWAYLPITKDEFDVSTAERLAGIHPAENTIPIIVPGPLSSTPAPTSPPFTSSRSMTSTSGISSPTQTQRVQPVSKTNLAAMVAGSVIGGGVFFVGLVLTTFYLLRRRRRALYAEKLDRRRNVILPPDLEAVPSPSAAPATGRKSTATRIMHSVDHTVLTDVASFHAPPIPVNSASSPTSPVKDLLHSVAGILRPTPAEGPPQPSERELDSGWREHPVATLPPAYTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0A1</accession>
    <name>A0A4Q9Q0A1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_847896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0A1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38702:SF1">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="816"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128997" checksum="F0E5707427872AD6" modified="2019-07-31" version="1">MDTPPDVSTTPTPDSPSTDTSGSSQQKKRRQVAFYPNMNSMNKPQKPFSRSAAKRESVMALGSIEYLQHYFTKTGIAAESDPLKKPKSGLVPAIGGLATLEKRPNNGGPTFVLPPSPAIPQAVHPTFPPYVKTLETDPDNLRPAVIEDLISVAAGWVLNPNSQQQPKEQEQGEQDPNLLGVGGGKHNRPSSNVDVLDLLKNTTRAVRSVRNYLVSLPDDQSVPQNRPHFRPNTLSSSPLPKRQVSQPNSPHDPLTRIRGRALEVLAVLRELEERARLPLDHDAYDAQSDHGSSSNDTNVGPASRGTSPSSHLEDGEFADGDTSVSVSFIDVGGRKRQVPVWDDESDDFNHLSEEDREKRERWDERLVLGGGWLYKQDLRMEDLEKEREIVSKYLDAVDEVLFGGPKDGQRGWEREKERVERKERMEREARAKGRRVSAGDAMSSGESSGRAKRRVVSTGMLDAMRNMVVTEEPEEMESIEEEEAIDDDELPPWAKRSTFPDDDYGRLHALLVALLPATLLRLLPMSSSEHADILRALSSGQLLCNAYNTAVRRSRKPWGYVSKDAIHDIAALEEAQGGDGGEAGKRGWTFRRTDNLRLWAAALKLRYSLPIAMPGGKRRDANTRPGTPGGGTPVVSPIASTITFPAGFASDDAIIFDAPLVARMEEGWELMLERVVFKWMEAVPTLIFLTAPTLLSFARRSLVAVVSKFGFLKHWQKRHPLIERGLDDQRYRVAPRGKRVLVSALLEVLRPVPADTPISVVEEFVVGQTQSPTCACEKPITYSTNRYETLDRLAATRFHVFCDSGAPPESTDYTTIVLLHGLGWHSGVFGKLIPLAHKYNVRLVLVNRRDYPGAVPYTAEERAHLLTISIESQADPAAAQPKMVAFMKNGGHDLHDLLVSFVATNNIPLSRSENSTGGIVLAGWSLGTCWMTAFLASTESFRRDNVDLSKYVRRVVFYGTCTPLAISIKVTLDSDQDPPSLALGYALIEDGYTPFADPSILAEDFVDEFNLWVSGFYQHGDTKDTLTFRDALASPPPTLTTLSTEERGAAAHSVPADPRGGSDLTIMVTGMVSGAFATLHEEALILSPAKAEQSPWNAVEVRHVCCGSSSWVMPWAMMSFQEELREKKNAGQKLRNVTFVRLRGANHFVHWEEPDRALQAFLDRAPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0B8</accession>
    <name>A0A4Q9Q0B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_975889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0B8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="238" mass="26358" checksum="B6115ED8CD1ACE05" modified="2019-07-31" version="1">MLAVGPEGLFDKVLHLHADLFESFASKWREVREVTFCVSFLRAEIGNAFFAALGHRKRGPWRRFRNKFTRMGALQEHGPLWRDKELSAAVTLERQGVTATVAAFGTSWYAQRSYQAKKEESKSPAAIPTWEYRMTSTQEHQPQSNSQEPLIHRTRGDSMEPVGPKDVPTPKDPAQPGTGQSATLSKVQGNQNKGEHQAVEPAVQPENDSKSSVASKARLVSARLSDFGVLIAPATAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1L6</accession>
    <name>A0A4Q9Q1L6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_235798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1L6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17306" checksum="CA285463C440CBB5" modified="2019-07-31" version="1">MLPRNFPTRGGVLLSSPRYRGREGGATAGIRHTHPLRHIPALPARRRSALPGAFIFLAPYQLPSFPHAMNDHQAGCPLFPLLPASCDAHVQLRAAKLARPTGASSGGHLPWNVFIYPNSGPDSLPYLSPASRSLSCGVPREPAPWPPCLRPADVLRNMAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1Q6</accession>
    <name>A0A4Q9Q1Q6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_966195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1Q6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="476" mass="51527" checksum="85AC962FB1307E43" modified="2019-07-31" version="1">MSYLTSDIAPEVFESALGTPFWLWNDREYVKLAGEQLREEMKLWDELPAWQRKILCKRDRFKGPRTLRTRRDPRIFTPAKKVKAASTSPSIVGRPVAECSSGAGSVREGGGSLSRTCSDAAGSQNVEMVGGPSSPDSVVLCPSVDRPNGTAATPARSGSSSDAVAGIVELRHVEMADDASSSPPASVVCTNVELLGTVIVAGQAAYPCVIVTDAAELQDMEMADATPEGPLDSDSGPHLDPDPDPDPDPDPDPDPDPDPDPDPDPDNPRSPSPNLIGQDLLKRLRAQLNAPQARRKAFSAPEKGEKMFNRPRPRLPLRFEKKRLTKGATPVKLTAPVQRGLQSSAEDKENVSLATANSVDVKVKAPAEAVPRKPKGILKKPRRAERPQPAVIKRARPGTQLQIQVQVPVKKSVRWAPEVIAKVSVFSYSELSRNALLTGTLNKLAQTDLETIVQAAKPPTPAQRLERLQQLVNTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1X9</accession>
    <name>A0A4Q9Q1X9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_975546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1X9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1X9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="402"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="525" mass="58234" checksum="8AE77D2F3EC2F9D6" modified="2019-07-31" version="1">MPNPPVTPTFAGTPFDNPAADVVIRSRDGVHFRVRSAILAEASPVFSEMLVSPECERTADGKYMIAIAEESDTLDPLLRLCYPVADPTFASLTDVRLVLAIAIKYKLEEASLILKKTLRAYMKDEPLRVWASACLLRLEDEARGAAHALFGKEIPVKAPPEFEEISSGDYFRLTKFLRAGGNVPESFKFWEPAMEDIPAAKDEKKTRLLLDSSPPIIAFQPRPYADIICRSSDGVDFRSHRIILCLASSVLEQKIAHLCPDPPRPVTGSSSTLPILELDAPGSALGPILEACYPTKRRLHLEVDLHELMTMMDCARKYDIQQALDSLGRGAFWLASRDRPLASYLLAARMGFSDYARSTLSNLSGELQIYGCPPEMEDTPATIYHRLLINRHQSYATTSRLTGTAITGTPTSTAPSNAAASPSRKTNTKSTTKPTVKVPEVPDPRDPWLLNLWRQTAHGLQGCKSTDIWRYEPNLAKLLKESLAKKIWCTKCEMNLGLMSALHDMYKDVRAAKFDHDYSRKALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q404</accession>
    <name>A0A4Q9Q404_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Chitin synthase</fullName>
            <ecNumber evidence="2 10">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_812611</name>
        <name evidence="13" type="ORF">BD311DRAFT_651337</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 10"/>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q404"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q404"/>
    <dbReference type="OMA" id="YANVRTN"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="534"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="700"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="737"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="12">
        <location>
            <begin position="44"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU33654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU61646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="767" mass="86223" checksum="4BE4F377972E5209" modified="2019-07-31" version="1">MSEPADPEKASLAHSASTTTEPETPLPTRHFGPAPTGRVLRRHKTKKRVQLTNGNLVLDLSVPPKLVLPRKGDAETLKTRYTAVTCDPDEFEKKGFFLRQNEMRRTTELFIVITMFNEDEVLFCRTMIGVMRNIAHLCSRKNSRTWGEDAWKKVVVCIVADGRKKVHPRVLDCLTLLGVYQPGDHMKNMVNNKPVTAHLFEYTTTFGLDENLKFKYPDKGIVPTQIIFCMKEKNQKKINSHRWFFNAFGPMLQPNVCVLLDVGTRPGNKSIYHLWKAFDVNSNVAGACGEIAVYKGKHWLGLLNPLVAAQNFEYKITNILDKPTESLFGYISVLPGAFSAYRYIALQNDKYGLGPLASYFKGEVLHGRDTDIFTSNMYLAEDRILCFELVAKRNSNWVLKYVKSAIAETDVPEALPEFISQRRRWLNGSFFAATYAIAHLGQILQSGHSVVRKVLLVFETIYNVVNLIAAWFAVGNFYLFFVILTSSLESDAFGMPGIKYFNAVSQFLMASLVISVFLFSMGNKPKASRWKYKICTLAFAVLMIYVIFAAVMCAVQAANQGGSSYSLMLFSIIVTYGMYALSSILAIDPWHMFTSFLPYMLLSPTYVNILQIYAFSNLDDISWGTKQDSEISTDLGAVIQNSNSQVDLEVPTDATDVNMIYEEALDNLRNRKPILKPAGLNDAEKEQLARDYYANVRTNVLLFWVLSNGLLLVAILGGGDAVDTFSVNNTFSRTKAYMTFILAFVAITSIVRFTGSLMYLTARVFTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4D5</accession>
    <name>A0A4Q9Q4D5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_153830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4D5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="154" mass="17252" checksum="D53F42DFCC54E456" modified="2019-07-31" version="1">MLDGASLLAGHRGTLLRATIAPEGTHVLAPFIRLCTATFRLSQRMVRAASHRRSHSAYTYADRAGAPRITRRHPRPVAMANVHASRVPRDVDDPCLVQHEHDRDPIGDAMLLHFRRCGVRENWRRGVRSFSACATLVPVQKDRSVLRRTGYAAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4R0</accession>
    <name>A0A4Q9Q4R0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidase S28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_843811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4R0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000368">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020210784" evidence="6">
        <location>
            <begin position="26"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="574" mass="64064" checksum="53A69EACA93CA5B4" modified="2019-07-31" version="1">MMTGRAALALLGLYAQLAVCGPGIADQIRVLGPQAVNLWRLQNQHAARARPQAQDPLLVQAQDGREDYPVSNTQAESKWGGVFPEHWFEQPLDHFAEGKGAETGAETWRQRYWVNTRHYVPGPDAPVFVIDGGETSGEDRLGFLDTGIADILAQATGGVGVVLEHRYYGESRPVKNLTTDSLRFLNNAQSAADSANFMANVKFPGIDEDLTASNHPWIYYGGSYAGARAAHMKVLYPDLVWGAVASSGVTHASIENWEYMEIVRRAADLKCSGNIQLTVEIVDSLLANPVTGRPIKGLFGLADLEHNEDFMSLLESPLGHWQGRNWDPEVGTTGWDDFCAALDGKFVQDPDMEFVSYDEGMDMVTIAEDLMVPVPVYNYARYIKQNYVSLCPEGAVEECFGTYDDSKYHDTDLDQIWRLWLFQVCTEWGYFSTAPPKGHPRIVSRLLTLEYESKICRQAYLPGKHFAVPALPNITAVNALGDFDIAADRLAIIDGEVDPWRPVTPHSDYARAREDTILRPFKLIRGGVHHWDENGRRNLLEEPAQIQMIHEDIVVFVTAWLDDWAAERAARARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4U5</accession>
    <name>A0A4Q9Q4U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_153065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4U5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17206" checksum="03B1478EAB7892D3" modified="2019-07-31" version="1">MFAVSDLYTQQSLPCLSVRCNSITISCSRAPSYISPASDRRTALICLRIMFYDHRPPIARRHRQQRDAQHSPLPGWHLGHALPSRTARSPHRALLRIECSQPALPGLRSQPAASLRRLPDMASSDPYMGRKVRRSGLSPACVAPLSTVAAKCPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5I9</accession>
    <name>A0A4Q9Q5I9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_810892</name>
        <name evidence="2" type="ORF">BD311DRAFT_660235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5I9"/>
    <dbReference type="OrthoDB" id="2749210at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11285" checksum="D901513A8FE8BE99" modified="2019-07-31" version="1">MQEPIIFNDIPTKAEGNRGKRDELTSIESLVPRTAVNSLRQPLPDQAEPQTIEAFLQQISPSMGRHAQVFRDLGIDVPRVPVLAQLDGESYLEFEDALVTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5K1</accession>
    <name>A0A4Q9Q5K1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_945963</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">PML body</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5K1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5K1"/>
    <dbReference type="OMA" id="HNPICDQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040909">
        <property type="entry name" value="CHFR_Znf-CRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052256">
        <property type="entry name" value="E3_ubiquitin-ligase_CHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079:SF4">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16079">
        <property type="entry name" value="UBIQUITIN LIGASE PROTEIN CHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17979">
        <property type="entry name" value="zf-CRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU62291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="438" mass="47883" checksum="1B34E0F3D06561C4" modified="2019-07-31" version="1">MNEPAPESVLDERRVGSGPIGLRVAVPQASTSATAPLKRRASEAFEDASNDETKHKKPKETNEKLVGESEEGSRASVDGGALSDNLEEELQCGCCSAIVYRPVVVNPCQHFFCGSCLMLWIKNGGTSCPACRTVSSNVSFSRPLEKVVDTLLRHAPGKARSASERMQADAIYHPGVHIRIPSPRQASPEPSLSSVNGMYVRPCPNCIPGNQWGWRCPQPIVDPDVDPTNAWPIDEGSPPGHGVCGNCENILALQAPTTTRCDFCQVSFCGINVPIRCIAGPIQNAQPHGLTDLSDLIQCGEVYECFEGNTVEVDIMLDYLSAQGLTPKHIYREIIQHIQNQPRQFAPLIELELFMDVHSTSGGVDPDPSAPRSRICRVCAAEILLYGLRDWWVRERKKGFLERHVLARPDCPEGSQCPRQKLHGPYHSLSSSQTLAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6K8</accession>
    <name>A0A4Q9Q6K8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carboxypeptidase C</fullName>
            <ecNumber evidence="2">3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_810999</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="2"/>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6K8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020935625" description="carboxypeptidase C" evidence="7">
        <location>
            <begin position="19"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="492" mass="55290" checksum="1C149780964B9EC6" modified="2019-07-31" version="1">MNLRAYAVLTLGSLAAGAQYPLGATTRGSWGSSAPYDAGLFTPFQDLNALSLTEYTTLLHPHFPAHSVRVKQSRFCDGEVQAYSGYIDVGARHLFFAFFESRRDPDQDDVIFWTNGGPGGSSMLGLYNELGPCRVTGPNTTERFEYAWNNHANVFFVDQPIGVGFSYADYGEKISTNAEAGQDIAAFFVIFFGHFTKFKGRPFHMAGESFGGRYIPVFASAVYDLNAKLGDAGLTPINLTSVMIGNGDTDSVATMMSSYDVQCGSYGFPKVTMLMDCVRTKQFVPRCQKRLKESCVDVVDHIDCLDAWEFCQNSLTQEILIRRNPYDALRPCLDKPDLESCYPMVGYTTTYLNNRSVQEALGIDPHHGNYSWVNWEVNARLNDDDRWFRAEHYLEQLLQRGVKVLIYVGDKDWICNWIGNERMTLELEWFGQDAFRSQPLRDWSVDGVVAGRTRSVGSLTFATIRDAGHMAPYDQPVRTLEVVNRWLAGQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6N6</accession>
    <name>A0A4Q9Q6N6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6N6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="89" mass="9690" checksum="A090C3D5477F4F7B" modified="2019-07-31" version="1">MDGLTTCVLVGRDYIGLKEHFSKGEWPASTYDKPGFLYATLVKLTGCPSGPALFACLQNLPFETLKNVSVATLTNEVLNGQLWQPTVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q717</accession>
    <name>A0A4Q9Q717_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_620383</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q717"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q717"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="297" mass="33196" checksum="D2D61B6B0C35CAF3" modified="2019-07-31" version="1">MDSDHEAYVLLLLSDSNLPTGSFVASAGLESYVTHGFFTDLSASSPSRPDKMDYTVNFLRDSLSTYAHSALPFVLDTHRTIEEYLQDQTEHTASDLDPVLSRVRELDELYETMTLNHITRRASKSQGVALLTLFSKGFSKPRLSRHLSVSSDSGLLDLETRATTLVDRLKLLVRREETHGHLPICWGVLTATLRLSPERSQYLHMFLQSRSLLSSSVRLNTIGPYGAQQLLLHTVRPLVDAEMSRCKDLTTGLLASSQNAEQDGLDDDAIRGPTMTWPLGEILTARHDLQHSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q913</accession>
    <name>A0A4Q9Q913_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_868133</name>
        <name evidence="16" type="ORF">BD311DRAFT_714050</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q913"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q913"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="161"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU64062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="603" mass="65600" checksum="75845790064E48F8" modified="2019-07-31" version="1">MSKLNANAFSFVPGQGFRIPQQQQQPQQAAQPPPQPVERPPQTQAPPPPPTISLNIGGSKSAPLPTAAPSPPATISLNIGGSKPAASPAPAPSPTPARAPPSKSEEPAKVAPAPASTSASNATNSKSFTLERAKTDSAAIADEVKKAVDEEVLKDLYGHIKEHLNIVFIGHVDAGKSTMGGQLLFLSGMVDKRTMEKYEREAKEAGRDSWYLSWALDSTPQERAKGKTVEVGRAYFETDTRRYTILDAPGHKTYVPSMISGAAQADVAILVISARKGEFETGFEKGGQTREHIMLVKTAGVQKVVVVINKMDESTVEWSKARYDEIKDKLTPFIKAAGFNVKNDVTFIPVSAYTGLNLKERVPKDVAPWWDGPSLLEHLDKMPMVDRKIHAPLMMPVSEKYKDMGTIVVGKIESGHLRKGDTLLLMPNKNTVEVSAIYNEVEDEVNDAFCGDNVRIRLRGVDDEDISPGFVLTSPSNPIHAVRQFEAQLAILDHKNIICAGYSAVMHCHTLAEEVTLAQLLHYFDKATGRKSKKPPQFAKKGQKIVALIETVQPVCVERFADYPQLGRFTLRDEGKTIAIGKITKIHDSGIDEAAEGVANLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q972</accession>
    <name>A0A4Q9Q972_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_868844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q972"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050460">
        <property type="entry name" value="Distal-less_Homeobox_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327:SF41">
        <property type="entry name" value="BRAIN-SPECIFIC HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24327">
        <property type="entry name" value="HOMEOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="7">
        <location>
            <begin position="32"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="34"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="312" mass="33700" checksum="933721C481FEAED1" modified="2019-07-31" version="1">MSVPLSPTISASSSDSPKLDPTRLACGPLSTRRRLAPSQTNALVSVFEVKTHPSREERALLAAELGMELKAVNAWFQNKRRTLKKTWSASSGWSKGSLPENKHVRPPDGPKALPRSDSIVSLDRVASSRELPYKAKGLPCSRLPPRVPVTPRRRAATAERSKDIWELLPSSPPTRPSSPSLGEPLLALEPCTKRLRTLEWACAKARAGRKASIRRARLAAKPAASEDEDSDVPMLVLDATPRKNSSAGDDTETEDDEAITPNVSTELLPSFVLPAEAEELDAGVPEPPVKDEDMDMEAAIALLGFMAPDPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9N9</accession>
    <name>A0A4Q9Q9N9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_914352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9N9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9N9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021627">
        <property type="entry name" value="Mediator_Med27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11571">
        <property type="entry name" value="Med27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="360"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="392" mass="42067" checksum="CB61D38F32A3E2F5" modified="2019-07-31" version="1">MSTPATAATPSVAAFAAPASASAAGLMPPPPVPPSAQPSAPDTTSGQPIASTTPASELTTLRTHIQTLTELNNRLQAIRNIPAQLLRPPGSDPSSTLLTHGFKEIAAIADTVRTERVQDALKAARKSEQADSSGLTSSLRRETLKRRHFGASPAACLFTEFACRRPPSPDSPQPYRETELKEAVFLPPVESGTSRILLDALPAYIRNHNKSSKNKLHLVAPRKGRELACPVTLRFTCPNVVTVYLTLDYSTDNDQILVVENATAIGSREQKQPHSQSDFMAFQQLSQQLAKVIRSDPSAPLQAYVALLSSYERLFVDICSNCQRVISAEGHVPPVVRKRLLSSSADPKAPQWDVRHVLCKYEPPAPQANPGDHGVENEGEGGGKNGEAGSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAM6</accession>
    <name>A0A4Q9QAM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_913182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAM6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAM6"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Prp19 coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="166"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="4">
        <location>
            <begin position="229"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU64717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="418" mass="44895" checksum="198B2B275616D4ED" modified="2019-07-31" version="1">MLETFSLKQQYNSLRQELSYALYAQDAAQRVVARLIKERDAAREALSSVAATMNVGASGAGGDVEMGEAAPEAGGLPAETLKQIDETHATLSAARKKRKAPEGYATVDDVKGYTAKHTIPSLHSPSPSGINSLAVSTANPSQFLTGGNDKVVQLYDRDTDKVLQTLKGHTKKVTHVAFREREGESTLVLSGSADKIAKAWTHDKASGEYKTAGTIKTHKGEITGLAVHPTSTLLALSSGDRTWSLHDLTNFTQVYRSPEFEEPFTSLDVHPDGTLVAVGTPGGSIQVFDIRSGSLAASLTPQDAPPFTVNTLSFSENGYHLAAPDSLASVAIWDLRKPKIAKSIPLGDAFKVNKVRYDYSANFFAVGGNEGLRVIAHKTWDELVRFEEGGEVSDIVFGAQGKEIWGVTGREVRIWGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBQ0</accession>
    <name>A0A4Q9QBQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Glycosyltransferase family 31 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_944062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBQ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051072">
        <property type="term" value="P:4,6-pyruvylated galactose residue biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002659">
        <property type="entry name" value="Glyco_trans_31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214">
        <property type="entry name" value="BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11214:SF333">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 31 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="795"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="844" mass="94906" checksum="7D6EFB3071B615FE" modified="2019-07-31" version="1">MSLVRDFLAPPSRPNVPLTRVTSAKDPDYHQNNSPSTQPGPSTTLTARTGTRRTTSLPQTPAPPYDEDDEFNSRAIRRSADRSRLYPPDAREAASHSVCSTATSTPIPSRAPSPFLYYSGTSSCDSDSESEPESPLLGEVGIRRRSGWLEDERPRWRLFRLGAGGHGNVHANGEIWRRRRRRWRDFVWGLRSSKRLLRRLVRHPFFPKTPVTILLTLLLFAIFGVSLTFLLIYILNPDKEPLPWRGYCTLPQRSAGPPSLSLSPTAFLQTPLPTNFSLPSFPPDGLDSLAPAGVFVGVFSMDTSVERRMLIRSTWASHVRSREGAGFGDGGVGTSRTIVRFILAQPQKEWERRVKLEMEMYKDMVILPLTENMNDGKTHAFFSWAANHSWVPPIYLDSHDKVPTNFTYLNATNPAPALAQHDPVFAHRDQLSASPRPWVRPDFVVKADDDSFVMLAELESRLRVELYKEPLPRPPSPPVRSPQWRQQSQPRDDSGEEPSVLDYNQIASYFNFSLPAYVTGFPTLVASRPTPEEPPSPDPLIFWGYLVKNRFMAGELYALSWSLVEWVSKDPLVKTMTRGAEDKQTSKWIRIHPRAGQVRWTSERCWIYDHPRAGTVYSHGFLFPSEMKRVQEGVLRDLQRLAQQTAVAESSAVANTLPGQHVAPPEKWTHSTVSKFHVRYSPPVADLNLDYSVEALVEGSDMSMVHDDGSMTADLAWQYREGRQQRYLGQRVGGTVVVHFIKKNMWFLETAAALLHGEDVTPLERALGQTRRAQQQLRTGLGDSSVDGVIEAAEGQDSSLSLSVGSQTETSPTPPPPRRNSLDSSTHTKARTKLRRLARDRTAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCD5</accession>
    <name>A0A4Q9QCD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_394273</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCD5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="113" mass="13228" checksum="E705A2AED453F73A" modified="2019-07-31" version="1">MGFRHRMRKRASIVFDVRSGKRNPMPVTLLLRRRQDPWADIMQTPSAVRRQTITYSRLLRNVSPLFYTWHITHSTSSDRGSAWYGATRHETAEWTDPLRDSPVNIAEYTPLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDB6</accession>
    <name>A0A4Q9QDB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_912098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDB6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDB6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="35968" checksum="176ED206605181A6" modified="2019-07-31" version="1">MQPIAQKILVVGGNGFLGSAVCRTALARGMKVASISPSGKPWQTPKGHTPAWVHKVEWHQGNALQPQTYAHLLPEVTAVVHTIGTLFEKSGYKSALKDGNVPRFVSSVAAAVAGGGVSANPLERESKRREGSYETLNRDTAVRVCETFLQSEPVVKTDGPRAFIYISAEDCNRPIVPSGYIETKREAEVLIEKMVQENARYRAVYIRPTLIYHPHFRPMISPAAALLDLSATIHSKLPAGFPTPAGLLRTLGSLMPRPVSGRESLVDSPFNSIARVLTVPPIHVDHVAEAVCIAADNSRTDVRGPYGLEALRELIGWHQKGQKSQQQAGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDD7</accession>
    <name>A0A4Q9QDD7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4211 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_943267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDD7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDD7"/>
    <dbReference type="OMA" id="HYVHFKR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025451">
        <property type="entry name" value="DUF4211"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14689">
        <property type="entry name" value="PHORBOL-ESTER_DAG-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13926">
        <property type="entry name" value="DUF4211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4211" evidence="2">
        <location>
            <begin position="142"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="46286" checksum="0C29227E08ACF7F4" modified="2019-07-31" version="1">MSAAPLAGDEEEEEVYVRRGKRAAKKTVVVLDSDEEEEVRPPKKRKLVKGERPPTPDEDGVDLMDEVDEHRIIESRLRTRDKRSAFQKNLEKLKRKKRGEIVQSESEEDEEEDPVPFAGAKPHDGSDHSHDEAAEEEEEDTFIVEDDSAQAIDLPAEFSMGTYQDLLHHFKIVCQMFVHIVVHDPEDRAEVGDRLRENQYFSVPLKIARRKLSGMRDSLVAGSTWKPTFRKALDTYPNLETQHLEFTVLGCDACNLGGRKSTIQGRLSGEPYDPVTYESVGEVEPNSDDEEGCCTKKEFHLGRFCAKRTRTYHQFTHWEFHLFHALREEVEMLNSSQDERSFVRVAYANGKQPPEDLSDADAIMDWLDERQIINIQWQEIKTMMENARHLEVRGGRGDDADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDG9</accession>
    <name>A0A4Q9QDG9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PPP4R2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_864822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDG9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDG9"/>
    <dbReference type="OMA" id="HMSDHPT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487">
        <property type="entry name" value="PPP4R2-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16487:SF0">
        <property type="entry name" value="PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="253" mass="27405" checksum="2122452B11385F28" modified="2019-07-31" version="1">MTTTPEQLQNGGLKLPPFPPREYPAGISNPPPKVDLSENEAQDLKTNIYAQLDEFDGYEEYSTPFTIQRLCELCVDPRKHYKYIGKYLRAVEKTLLITSTWDSFPPLSEIDSTYSPVGHSSISTSTVSAPNTPMFSPIPFLHEDARRSKSRSPPPSPLVLPATIAGGLSGADESADVKALGLVDELDDPSPGHLSDHIEPISSTTTVDSRPLHGTLEERFVKASEGASAGEGEPSGDVPMAQDEDEGKENRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEC7</accession>
    <name>A0A4Q9QEC7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_943247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEC7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEC7"/>
    <dbReference type="OMA" id="VKMFATN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901991">
        <property type="term" value="P:negative regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098813">
        <property type="term" value="P:nuclear chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000016">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028043">
        <property type="entry name" value="PP2A_B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="636"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00064351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="699" mass="78471" checksum="715E559C43239B9B" modified="2019-07-31" version="1">MKVSQLGRKNSTDSTSSKSKDPKAAANAAAAAAPPPPPPNSAKPLPPPQVPGTHLSNASNHQLPATNGSSSASAAAARLNAAVNTTDRRYVNPSGPGVAPPIVVVSPDAPSNEDRLPENGPVTPPRVGSLATRGLRPAPKDTIPISGKPPRKQRSSRFVVNEKVEIERLPAFNETPASERPQLFIRKLHQCAVVFDFNDANSELKGKQIKTQTLHEMLEYITTQRGVITENVYPEVVKMFATNLFRSIPPPVNPTGDAFDPEEDEPVLELAWPHLKIVYEFFLRFVESQDFNTNLAKRYIDQNFVLNLLELFDSEDPRERDFLKTTLHRIYGKFLNLRAPIRRSINNVFFHFIYETERHNGIAELLEILGSIINGFALPLKDEHKTFLMRVLIPLHKVKSLSMYHPQLAYCVVQFLEKDAALAEEVVIGLLKYWPKVNSPKEVMFLSEMEEVLDVIDPAEFQKIQEPLFHQLARCINSQHFQVAERALMYWNNEYIVNLMSDNLSVILPIVFPALYTNSRSHWNRTIHALVYNALKLFMEINPDLFDEVMQQYKQRKLDERQHAVARYEEWQKLREQALRNCGGKLPEGYVDVEPTPPPPPVEDFDIMDLSIDLNAVSIDAEAPLGELDESGIERVPMADPGMDRPFPEVGQEHSSPGGLHSRRKSALPVDPTVLRDLQAHKSLEDTVAPRGRIAGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QED6</accession>
    <name>A0A4Q9QED6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_804114</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the CKS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QED6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QED6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902554">
        <property type="term" value="C:serine/threonine protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.170.10:FF:000002">
        <property type="entry name" value="Cyclin-dependent kinases regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00944">
        <property type="entry name" value="CKS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="121" mass="14080" checksum="D460B8E0C7976E5F" modified="2019-07-31" version="1">MATKDPKAAEAVRKLEEYIEKIHYSERYSDDEYEYRHVILPKPLFKMIPKNFFSSDDSGTLRLLSEEEWRGIGITQSLGWEHYEVHAPEPHVLLFRRPKNFDQVMASRAAASAGKAQAKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEI0</accession>
    <name>A0A4Q9QEI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_911628</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEI0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEI0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="36"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="614"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="875" mass="96507" checksum="A316C80D8D8A3F70" modified="2019-07-31" version="1">MDVPFSSSGAMSRAHYALVRKVETATPQAADQILLAEVQTIRNQLTRSTLTLKQCKEYLVLLLYCSMAVNPGVHVDLEFALPHAINLAEAGQTIQDKRAGYLFCGEVMPAEHELQLMLVNSIRKDLESSAISRICLALDTLIQSPSRDVIPAIQTRLHDLLSHNSPDVKRRALLAFNKLSEYDADILHDIASKARKRLSDSDPSVVSAAFTLAESLLKGKHLPEDKYHSVVSGLLDATWSQRPHPSESRLLVRIIEVITQLGPSKHDLEVIADVVRYYAHRGRAAYALLKQCFRGVSVSSTELLVEVQASSGISFIKEMRHLLAVQEPNALYMFMSCLSSVDPQLWAGTTPEIPSVLEEWEVERIMKALDCEDKLIRKQTLRTLWRVDQNIVESYYARALQGDLPSSSVHGTEDHLPRLLEIVDIICGDDGEAYAIQLKNVLNAAEGDGPLNKRPVLQEAVEEMLARIHTADSIWRSACIGVLFSSVADKENEVGPTLMVILTALFCEYLELSPLSPVELLCGVADRVTSYSPSIQDACLITMLRISAACDEIPSQAIEAVKSLQDRSGRHLARRCVQFTTLSQSKDTLRRVIADTRSSSLPDFVLALEKYQADQPRGASRSPSLVPKSPPLKPHTPEPSSSRASPLPSKLRYAAYEAPRHTPKLRRKSSSSSRHSDDGSSHGGLGRSSYQDPMTMTITPGDLSLAAQTSDLRSIPSSSPRMSRMSPLPVVQILNEEPPTGTGSGAADLIALDSPFISEPAGPSLANTISSIMEQDFEATWNSLESGAARGWCEASIDAVLRRLQGLQRRLRVTERDRPPFEGDLKIVIAPESADNWSKKGLAAIRLKESDDDSCLWWLRCEDDELRNIVKATLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFD5</accession>
    <name>A0A4Q9QFD5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_32729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFD5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12313" checksum="1426F6507D658608" modified="2019-07-31" version="1">MSRLVGAPLLRLRTLLPSICSILTIVTERAVDLARQNITLYLVHVMFIPLQVTGPFSVASRHSSSARALLTSRIKLPHAWQLHSASFCSAGRFIKWQEHYRHFHALLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFM0</accession>
    <name>A0A4Q9QFM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_911818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="330" mass="36639" checksum="517A21570AE38543" modified="2019-07-31" version="1">MTMSAPQSAADFVSAVRLDSSLTLAAFSILYYDYALTITSEIEYYWNPPSMSAPFVLFVVSRYLGLLGPLPVFFEYFGGFPEHRCRQLQFYHQIYAYLGQAMVGVLMILRTYALYNCSKRVLAVLIFIHICGGIQCFAAILTSHSSLSINTPLGFKFPGCNLSLTDEQVLIDFAIAWSALLWFDTTIFVLTLYKSIKIRHEIRGGLPETMFRDGTSSIVLSVAHTQLSLPRFAILCPNTPLKGTATTLTNVMSVTLVSRLMLNLRSPTARDRRRLGGSATVWTSGRFSSRVMTFMQPTLITDNILLDDFPSDSSESSGSSRTVATEVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JYK9</accession>
    <name>A0A4V2JYK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_844456</name>
        <name evidence="6" type="ORF">BD310DRAFT_860174</name>
        <name evidence="5" type="ORF">BD310DRAFT_889839</name>
        <name evidence="4" type="ORF">BD310DRAFT_890967</name>
        <name evidence="2" type="ORF">BD311DRAFT_616071</name>
        <name evidence="3" type="ORF">BD311DRAFT_664239</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 8">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143595">
        <property type="protein sequence ID" value="TBU21573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML143426">
        <property type="protein sequence ID" value="TBU27979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145352">
        <property type="protein sequence ID" value="TBU51254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145263">
        <property type="protein sequence ID" value="TBU52161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JYK9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU27979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5334" checksum="9626061547FF5444" modified="2019-07-31" version="1" fragment="single">RSDPLGSDPGSSQGDINVGASGHVNRRVGRPSATRCSLLELGLAFSGHEPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K0N2</accession>
    <name>A0A4V2K0N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pali-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_404635</name>
        <name evidence="7" type="ORF">BD311DRAFT_756307</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143412">
        <property type="protein sequence ID" value="TBU29523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K0N2"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF3">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040684234" evidence="6">
        <location>
            <begin position="28"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU29523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20006" checksum="EA1B0974D607DEAD" modified="2019-07-31" version="1">MAAGAAVPGLFCAFAAMVLLIFASVSAPTWERISFLNAPTGGTTTHFGVFGFTGSKAHVGWFFPSGLGDSKLDDGLFHNLTFTLILIPIAAGLSALAVLFGLCGAAYHRAGTVLMTLVSALAFLVTLVAWVLEMVLFGIARDHMRNRNINATWGNANWMVLGALVALFIAFFASLCGSFGRYSTRRTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K580</accession>
    <name>A0A4V2K580_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_867413</name>
        <name evidence="13" type="ORF">BD311DRAFT_688488</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K580"/>
    <dbReference type="STRING" id="114155.A0A4V2K580"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000499">
        <property type="entry name" value="Serine/threonine-protein kinase KIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF21">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="356"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="701"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="775"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="910"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="737"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="779"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="817"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU31578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU64459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="947" mass="102747" checksum="8B4508414EEE2C6C" modified="2019-07-31" version="1">MPPVSVHQLYQRLETVGKGAYGSVHKGRDLRTGEVVALKIINLDTEDDDVGDIQREVALLTQLRDAPNVTKYFGCYMDGPRVWIVMEYAQGGSVRTLMKACKDGVVEEKYVSVIIREVLNGLSYLHKSSIIHRDLKAANILITSTGKVMICDFGVSALLVTASSKRNTLVGTPHWMAPEVAHASAYDTKADIWSLGIMIYEMIKGSAPNSHIVDQAKLIQLIPRMKPPRLNEGEGSRELRDFVAACLRESPADRLSADELSKTKWIVSVRKVPVTVLKDLILRYDAWTKGGGSRASMAQPLPWEEEEERERNPQADAVYEDDNPWEFDTVRGRSTLSLDNFEVDNSLLAMLEDESIGEQSTVRPPPTNVPATLRNLFDYGDPPPPEPFRMPTFDSPSDDPLMTNPSLNLSAALPSRGRSPSKGLTTPEPTLVEDLRTAKQSSFVFPPRASTPRSKTPAAEQDESELPPTSPIERKRDRLPPLGPGIPRMLAPISTSSDSDSKPPALSSNKSAPTYREIRSNRGVPDIEIPGPSPIEASVDSPPPIVLSTSSPERTTPSRPAPNRKRSQSSAPGLSSPSATGITSATPRERNLATPDFRFPPLSPSLSADRNNAVPSPVPTFRLPHGHDRRSPTHSSVSTISTISTVSTTSSVHQTSQSLDASILPKRLASPGGSLPMPPPIMRARSATATTEASPFSAAQSLIMSPKGPSRRPSLHRLGSASVLDMPTRPFAKSQDRSGSPVESSFSTSSGIPLPGLRDVLKIPTINFEHKHAHADLLPPSPAPYPVPPRSAKSPLTQLNSTASSSTTSLNSLSSQPNMSSTDLRFASDSSYTTHSRSLSLGGSQTLPLVPSDMPPIRPLDLGPLMHSHDLTHAELARTVDELQSWMQVVEAGLAQMLDRAAQDQLTIEEETEDAGVFDPRLDDDPLQLSDGRTTTPHPYPLPLPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6F3</accession>
    <name>A0A4V2K6F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phytase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_941068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145267">
        <property type="protein sequence ID" value="TBU52083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6F3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF42">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="584" mass="64276" checksum="33A214A69F456863" modified="2019-07-31" version="1">MRSQHKLSLDADLLAHNGDRARSRFALRHVLFAFVAGFLSAALFPLLPSLPLVQILDPTQSLHPRPGSTDVHHYPPSHPTNAFPDLFPSDVGYPGPTPTGAEPALVATAPAYPLHTGPPHLLRPQALSNSSFDIFSHWGNLSPWFSVPPQSFRIDASLDPPQGCRITALHLLHRHGARYPTGTAAYAGPANFSARLRHAPHKWSAHRQLAFLNDWTYKLGEEILTPFGRQQLFDLGVSIRIKYGFLLRNFTASNTLPVFRTESQDRMLLSALNFALGFFGPKLDGQYQQLITIEAPGFNNTLAPSKTCPNARDPARGERALPYVRQWAKVYLQAARARLNSQIDGIDLTIEDVYAMQQLCPYETVAIGYSKFCELFTEDEWRGFDYSVDLNFWYNSAFGSPTSRALGIGYVQELVARLTSTPIAAHNSSTNATINDDPATFPLGLSLYVDATHDTIILNVLTALNLSNFATDGPLPSDHIPTNRSFKTSHLAPFASNVQFQLLACDSAPEPQIRIVINDGVTPLSSVRGCPADEPHGLCPLSAFVSAQRETISKTDWTWACHGEWNVPTGHGWNTTTGEPPAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6V6</accession>
    <name>A0A4V2K6V6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">General transcription factor TFIIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_829566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIB family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145207">
        <property type="protein sequence ID" value="TBU53683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6V6"/>
    <dbReference type="STRING" id="114155.A0A4V2K6V6"/>
    <dbReference type="OMA" id="RMWQRRM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIB-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="359" mass="40179" checksum="28537A270167B45F" modified="2019-07-31" version="1">MSYAQPFPLAQSVQNSGQTTFAPDLAVRLICRDCQEYPPNIVEEFRDGDLVCGSCGLVLSDRIIDTRSEWREFTSTHSDETTHAHCRVGQVQDRLGVGLEHLATTISVDSGSSISQDLRRVARQAENLSPSERRVRQAFRDIDDMCARIQLPNTVLDITKQLYWRIDQENIRPSRLRSRAQYEATLGACFFIACRQARVPRTFIEICQVTSVDKQDIGRAYRELEQKFNLRSGSTVGYDEESGAYEGGPQDLLVRYCNYLGLPQSVVSVSTDVVVKLRELETPTSRSPPTIAGGAIFFASHLLGHPRNFQQIGKVAGMKGVSMAVLYKTLYDLKDKLVSDALIRDGTAKLDRLPLPTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6X9</accession>
    <name>A0A4V2K6X9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_951767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145201">
        <property type="protein sequence ID" value="TBU53958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6X9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="44334" checksum="45E9B704B7889C41" modified="2019-07-31" version="1">MHRLPYDVQLAIVRLLSVQDVIRFCATCKASQEFMRDRTIWHHMLSRLLLHFPNPQLSLRLVSMEVEEMKRWVLHSAKLDRMWHKIDYHPRLIRDLHCDKRVEHVNLVAGGDWLVIVLRDGSLQLHELGATAPAATLSQPLTQDESVLYLSSRLSLTHEREDLIILQMGVRYNQCNIYVYHIAVVDPVPTFLRVGKISVTGSVWSCASGLHVLVYGLESGEGDMILHVYPLGRQYADVEGPAVSMNIGPWSADEDFTISVLSDNQIILAYQGVWSTTADIGSGIYRISPFAHNANARTHPLVIAGTRALHVLRVFPDSRVDYREVPYPLALGAEVGYMGLGAVGVRRAIWDCTEARNGSLHVHFRTGTSTSSRRESWAPGASSARSASGSIPRSTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K719</accession>
    <name>A0A4V2K719_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145189">
        <property type="protein sequence ID" value="TBU54428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K719"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="449" mass="43958" checksum="5877B86BFDAA93B8" modified="2019-07-31" version="1">MAYDYYRNSRPGWGTSQFQFGPPPAPMFQPQPSWSGLDFYSAHAINPDPMFYNSIMSRASTFGSYGLTRDDARYWHRRIYSGLTPLAQVLPTDIGAAAAYEAYRTWKNNSFLYEPLSADRVQQRDGLIGMAIAEATRLWQYSGRPADTYGLRAAAEAAASVASVLADRWIGTMGAGGGMGGMGGAVPSYASSGGSYGYRGRRSSISTPLGGPMGGSPFMGGGSPYLGPGMGAGAYSPVPGAAGGIGGPPLGAAGMPPGIPRSISPMPGAGLGAGPGMGMGMGGAPGIGGAYAAGMGLGGAGGGMGLGGAGAGMGAAMGAYGDAANVNLQSVPPGSTIIVKHGRRRRHSDASGRRRSPSIDVIHTGGAGAGGAYGGMGGYGGGYGAGYGGGYGGGGGYGGGGYGGGYGAGPGGPGMCMGAGMGGGAGMAAGAPYGAPGMYSRPGYGGGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K949</accession>
    <name>A0A4V2K949_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_918645</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K949"/>
    <dbReference type="STRING" id="114155.A0A4V2K949"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000535">
        <property type="entry name" value="Chromatin modification-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="485"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="264"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="377"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="538"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="389"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="551"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="515"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="528"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="502"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU62548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="561" mass="61007" checksum="9C1F8A5D6C8FDE65" modified="2019-07-31" version="1">MRSEKAAMVRSLDLRGCRRRRDREERVIVVHAMALHLSTTARASRRSFWSSTDASESILSAPRVRIAGPAVRCMSAPAFRVCRGWRRAGPPAATRASPRPASHNVPLLSGAMSRRQQHTMNYPAGPSSAVDTALSLACLSEYAHTLDSLPIDLSRSYGDLRELDAVLSSSMTLLTAKINELIGMIETKTGTNDDRLYLLTEISEEATRLKLGGEDKIRVACHAADGLRSHRTHMRALLDRMPDREFLKIAEQLGRKTVYPHVTSKQYYPPGMTGEGGRRNRRQAGANTGYGGLLLNGTDPSPEKKKRRAPRDDDVDVTRTPSKKERLEGGPAPRQRNGARNKKVPAADRAASPTESVASLASHLPQHFVAQPNTVASNRAASNSASNKRAQEAAARRDAYSAQPPSTSHPSLPQPYLSNQTGIIPDPPSTRAMSNGIVSEWPHGQLEGPGMPVVRNTFPQVPAADGNDGTMSAGGEPDGDAEDNKTYCFCESVSYGEMIACDDEDCEREWFHIACVGLTVLPAGTWYCSKCLERRQNQKKSGRGGKKRSAGGRSAARNHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Q0</accession>
    <name>A0A4V2K9Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_805944</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V2K9Q0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038066">
        <property type="term" value="P:p38MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06626">
        <property type="entry name" value="STKc_MEKK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF32">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="924"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="830"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1083"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1261"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="444"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1263"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1293"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="953"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1316" mass="148283" checksum="AD1260F54D07F328" modified="2019-07-31" version="1">MLDAEPIEPQSLEDRERLEWQTMLASVLAGDVLKAENTRIAVALNSSSEEENNPRSGIWLGIRARLHGRTVEEERRKLEERRLRTVKPVIEEVLNFRVQDPPAGSTEGRETYALQQVNAVLRRLEIAHSLYPSLRAFYIDCQSAVDVEFQSRCDTLNTWSTVLTSLRQLLGTLRKWTGSETMDVSQPSSHPPTPSLRYSENANGGGTTFVERFLKEESIQRQFEKGSMTTIHALVGTTRDAHVNLAPMFKKMNLPSFEQELVPLVSFLTNLAQAVLRVRLAYAQKLKNPDVLIIDQMTDDLKVKIGFACTLKRQYEAFLVPDPGGNWRLPPCISADYDSTILESLTFFFKLIHWKLKSGTKGIHFKETDVIEAQWATFNDVSLTIPGGATLVAEQLCALTNKLIVRVTNYFDTSIRVPGMADGSLSEMLSDRVRKVLRSSGLNGTPTGQQTLPTGLQPPSANVPKDRLVTWYGKILDGVKQRSRKLLRLGRVLSRRFCDSAEYDLEDASIDVFIATLVESDHFLVYTQTFEEEGTYIVGHPSLRDRPDTIRRLLLDAFHVHEIDESSWLMDMGEAEPEEVEEDASYLLVLSPRTRFLWNGFVLMLQLPKIDLHLEDNRIRLIADGSQHRLVAAKRQFSEFFQSVEDEETGEPIEPAMPMPNCLIEQQAHLPSVNRELRKIGRATNRLAESIVESVHYVRQTLRDTTNYQELLENWYVFASDYGAHVEKYMDQAMLLKYNQSLIKLAISWVSFICDDCDPNDRKTFRWAVTALEFTLHRTRRNNILHLPDDQFEMLRQKVATCMTLLISHFDILGARSALDAKREKERQEELLRLRTSNRRSDEDEEEAAFQASPENQDSVYAYIDPALRAFWQKTSDFARELDEQRAQMGTEHHIIGRVLDERVLVDRSVVFLAGSSSNVSIRWQQSRFIGAGSFGSVYLAINLDSNTLMAVKEIKFQETAGLTSLYSHIRDELAVMEMLHHPNVVEYYGIEVHRDKVYIFEEYCKGGSLAALLEHGRIEDEGILQVYTLQMLEGLAYLHSQGIVHRDIKPDNILLDHMGVIKYVDFGAAKIIAKNRGTLRRTRRSDSSVASPGSAAADPDQLGLNNSLTGTPMYMSPEVIRNNKLGRHGAMDIWSLGCVVLECATGRKPWSNLDNEWAIMFHIGVATQHPPLPEPGQLSEMGIDFIRRCLTIDPLARPTAIELMDHPWMLDFREKLEDYEKAENVIASGASIPAEGTYEAATVARQAAILQEKETELIAAQSPSLSPIQSPESSSVNSLSPGLNDARLDLLSSFSTPDSSSSSANGNSSGSGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MAW5</accession>
    <name>A0A4Q9MAW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_83074</name>
        <name evidence="2" type="ORF">BD311DRAFT_769763</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143526">
        <property type="protein sequence ID" value="TBU22801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145192">
        <property type="protein sequence ID" value="TBU54293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MAW5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU22801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11443" checksum="7937329F260304E0" modified="2019-07-31" version="1">MLDVVQWQAQAPGHRVKLIRCTPPGVSVIASTFIRLTRVILFTHECCCGDLTQISPGLAMKLLGSGDRSRLLGVHPGPAVSFVVICRIVPPAVVPLAVAWMYLVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MKG9</accession>
    <name>A0A4Q9MKG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_966663</name>
        <name evidence="3" type="ORF">BD311DRAFT_354080</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143425">
        <property type="protein sequence ID" value="TBU28074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MKG9"/>
    <dbReference type="OrthoDB" id="3251587at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597582" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="66"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU28074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="377" mass="40591" checksum="CF6D510C0394357D" modified="2019-07-31" version="1">MSVLNVSSVLLLLFFYLFPAISAAAAHHPAPRQYTTSSLNVGNGTTLAYLDSGAPSSRTYTTIFAIHGMGFQSPVWEKVLDLAPAYNTRFVAINRRDYNGSTPYTAGDLNVLQNGTVSEQTAFFQQRGEEIATFIELFIKQNGLPAPSADGKTGGVALLGWSLGNAFGVSTIANIQTYATSTQQTLAKYLRGLVLQEPPSVSLGLPLPPQSWSPQIDTSIPAADRQPGFVQWITAYFQHGDLSTRDVNVLEYVLPSITHVPSVFSFTTDQLAGVTNLAAASGGDTFIVGYNQAALLPTYRKALFNKTVRAALPLLNVLEFTGDITANFGIVALWQIQDDDAAAGGGFVKTEILKGTNHFVHWDQPALALSTYLSVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MLL2</accession>
    <name>A0A4Q9MLL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_817588</name>
        <name evidence="4" type="ORF">BD311DRAFT_778268</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143421">
        <property type="protein sequence ID" value="TBU28520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MLL2"/>
    <dbReference type="STRING" id="114155.A0A4Q9MLL2"/>
    <dbReference type="OrthoDB" id="2782214at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="255"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="44"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU28520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="290" mass="31975" checksum="D1AECFC2A5077202" modified="2019-07-31" version="1">MQSSSAVMPSTTRRDFLGHTSGSRQMPLDLIYEDHPYEHADYKSYSPDSPNSPSSTHSGPYERQYVHTTTPYTYSPHGVPNHTSGWQPSIADLRMTRPRSTFPHMNAAPYDLPRDGHRSLPPYSGMESDSYRTTPSFSPSYSNIANAGRYAGGVLGQSTTGYSYACVDQLSSAVSTNHGHPSEPRCEWESQHCGMLLEDSSPAGIARHLRQYHSVAVTDNRNRGVCLWGGRCGKDMYPSSFGKHIAECHLRNMTKQCPHCGSDFARADTLSRHIKAFCPNTAGGRVHSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MQJ2</accession>
    <name>A0A4Q9MQJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_420541</name>
        <name evidence="2" type="ORF">BD311DRAFT_324878</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143421">
        <property type="protein sequence ID" value="TBU28511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MQJ2"/>
    <dbReference type="OrthoDB" id="2754366at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU28511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="37310" checksum="D0A12670914415A5" modified="2019-07-31" version="1">MLSDLRNLSCQPLWAAMPYPHHPSPLSITVTRLTLRFFGLAEVLAFAMMDPNLEVAPFSYPSNFRSKLSNLWWNRRTATPSQLTVSYPRQHCKSCCLALSRRSSTNYVHTDHTVIYNPSLPQADCGRRTFPPPTQTCLDVNIPSPLLPPISLIRLSFAQVRKDIRWRPEGFEMTAEDKDLTPFALRSHTLVPLSLAYFRDDIRRRKEAFETSLPLEPQIEDEERPPSPSVGSNVAERTKLGTVPVSVAFPNTYSRNSSPGPTYSCPVRGRPPFANAMDDGPSIIDDTLIAVYEDYGALSLYEMGYGIAEESARESTYKPLETFLDLEDASFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MVL2</accession>
    <name>A0A4Q9MVL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_921791</name>
        <name evidence="16" type="ORF">BD311DRAFT_690542</name>
    </gene>
    <organism evidence="16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143404">
        <property type="protein sequence ID" value="TBU30692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MVL2"/>
    <dbReference type="STRING" id="114155.A0A4Q9MVL2"/>
    <dbReference type="OMA" id="INQRDNW"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="183"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="413"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU30692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU60944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="543" mass="58858" checksum="F9C57F8846C49BF0" modified="2019-07-31" version="1">MHRVALRNSVRAAALAATKSAARSTPAVSRSYATAKAAASEVSSILESRIAGTSVGANVEETGRVLSVGDGIARVWGLKNVQAEEMVEFSSGIRGMCLNLEADNVGVSIFGNDRAIKEGDTVKRTGQIVDVPVGPELLGRVVDALGNPIDGKGPIKTSERRRAQLKAPGILPRRSVNQPMMTGIKPIDAMVPIGRGQRELIIGDRQTGKTAVAIDTILNQKRWNEGNEEDKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYTIIVAATASEAAPLQYLAPFSGCAMGEWFRDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNEKFGGGSLTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFFRGVRPAINVGLSVSRVGSAAQTKIMKKFAGSLKLYLAQYREVAAFAQFGSDLDASTRFLLSRGARLTELLKQGQYQPLAMEIQVPIIYAGVNGLLDPIPVDQITRWEAEFRAHLTSAQSALLQEISKGQITPEIESQIKKVVEDHVSSFTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MW69</accession>
    <name>A0A4Q9MW69_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_837601</name>
        <name evidence="12" type="ORF">BD311DRAFT_775344</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SPC24 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MW69"/>
    <dbReference type="STRING" id="114155.A0A4Q9MW69"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU66092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21090" checksum="CC467F90BB36A5AB" modified="2019-07-31" version="1">MSINIKDTVKAIREMVPIIDPEDDYLTIAAAEEQMALKQDARQKELHDAHAKLKQLAKVLEAARVSATRPSTIPSAEEHVAHMNDLDATRLSLAKAINDAEGALAGKEAELARLKEETRVLETSDPAADHDLDATTLRLALYKGLGFEPIMDKGGRMLVRAESGDVHCLTFDDRKKSDEEYANELWRLASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGD4</accession>
    <name>A0A4Q9NGD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGD4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="131" mass="13829" checksum="D5F1AFFE141BED83" modified="2019-07-31" version="1">MRVSVLSLAATVFAGAGLATATPLQARGDQTIILPLSGDPIGTSFEFQFADESRTASSTSFVRATLKNSTFSAVIADDVPFEDAHPDRISTSLSVPPEFGKGFYDLVVEEIEGDGSVVFTGESTDLAYLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHV4</accession>
    <name>A0A4Q9NHV4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_937306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHV4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHV4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015254">
        <property type="term" value="F:glycerol channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050363">
        <property type="entry name" value="MIP/Aquaporin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829:SF14">
        <property type="entry name" value="AQUAPORIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43829">
        <property type="entry name" value="AQUAPORIN OR AQUAGLYCEROPORIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU53755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="331" mass="34502" checksum="9D61F01F3CF28A51" modified="2019-07-31" version="1">MSAPHTTVPVSAVVPRAPALARWEKTKNRRVSWLVECVAEATGTFLYTFAGAGSTASFVLGNILKIDGLGSLLQVGLAYSVGIALALAICVTTSGGHFNPGFTVHAVVFQGFPIRKALRLIVAQIFGAYIACLLVYVQYKQLIHTAVDALKGAGLYESLMFTPNGPGGIFGLYVNPGSNLGYVVLNEFVCDFIIGICVFGVLDPSNHLASPTTLPWLIGLAYGVVIWGFSPVGVAANAARDLGGRFAALTLFGTAASGGKYAALAALTNIPAILLAGLFYEVVFADSTRAINPDWHQIIAAMQANAVRKAGGESGSPSPPASILSDEKLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMV5</accession>
    <name>A0A4Q9NMV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_809784</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMV5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="426" mass="45599" checksum="A59087C69F511DB0" modified="2019-07-31" version="1">MEKGEHPLQKEAAAAPVLTKAQRRKSWLQFGALCMAIYVAGWNDGTTGPLIPRLQEVYHVSYAVVSLIFIANSIGFISGASVYMYLTDRFGFGMQGLLTVGADTASLIVAVGNALQASGAPFPAFVIGFLFAGFGGAFLDAGSNGYLASLSEDTSTKMGIMHAVYGVGAMCAPLVSTKFASLPRWHLVYLVHIGLVVTNGLVQAFTFKFKSTDECLKEVGQQPHEKTEDSLQGVSKYKQVFRLRAVHLMAFFLLTYVGVEVTIGGWIVTFVINERHGGHSSGYISSGFWGGLTIGRLALLPLNKKLGEWRVIFLYVLLSLGLELVVWLVPSLVGDAVAISFVGFFLGPIFPIVMNHAGSVLPPELISGSIGWMASFGSAGAAVFPFVTGAIASGTSINSLQPLLIAMMGLLLVIWALVPRHRIKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NR72</accession>
    <name>A0A4Q9NR72_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145207">
        <property type="protein sequence ID" value="TBU53705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NR72"/>
    <dbReference type="STRING" id="114155.A0A4Q9NR72"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="59865" checksum="83CCBF103AF5CCAF" modified="2019-07-31" version="1">MSSPPAHPFIDPSADVVFISSDRVAFKLHRVILSLASDFFKDMFALPQPDHPPSGVQAQTDNTSTDAKLDGLSEISMTEPSQVLDTLFRLCYPLDDPPLETIDHVGAVLEAALKYELRKAIQMTSRRLRELIPSAPLRVYAIACKLSLEDEARAAAVVVREKNVQHEYVEELEDIPIGAYLRLLYFCETGRDPGGLFFSHRSSSPRSSTTKKKKSKSSKSAAGGADSLATSVSVPLPPSSLSEATTPSPPPTPPRGAYPFDRIDCEVEFETSDGVRFGVSKDMVSLSSPVLYALIRDLPVPARVTIPESSKVTDIILRICSPVESPSGVKTLDLDSALAAATKYKMPKAIQFLRRALLARADTDAATSLLLYAVACRHGMHDLALVAAKRTFRMELTSSLYPKVEAIDISAGYLYRLLEYRRRCRDAVRAILDVNKTDWIDRGWQPRLATCCLSTRSALPCWYGRYIEKMAGEDWPGPASVVKQEVLQAALVNLSWYNCSYCLRENGAILLYQFGQYVAETILKLEDQVALEWPPEVVVGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRQ4</accession>
    <name>A0A4Q9NRQ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_239185</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRQ4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NRQ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22585">
        <property type="entry name" value="Rcat_RBR_DEAH12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="28"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="811" mass="89816" checksum="0091D299BF683333" modified="2019-07-31" version="1">MPARSLPFLPRCRACAFWHHSGSARPNMLIGPASRSGDHQPIQRHRTHPVVNSQHEYATRTPRTQSHTQNPLSSIPPHVSGRLSREQSQSSSDNPVVPPGLGLEAESREENITLTILDATKVTFGPGFGVIEVKTGFESRQILLENVPATIAPVDITAALSIFGEVIAVLPVDPNEGSSSAYKVTFARGESAINAAAAVDSSELFAGSEVKACMTVRNSTGIGGGKLYDGDVLFELPTARQKGYVGYETKEKAEKAIALAQQKGMKGMRVTAQIYEGIPVVGAVNVRFENLPGDASAKDLARYGPYETHMLDRPKYNWTVNAAVDGLRRMLEGYGDVYLNVLPPPYNKTFRVWAHFKDPRRAAAAQEALDRFCPRFVGKQRIFAHHVRSILYNLPADVFDILAYDINLLRSYHCDEYATSISVFDRRIVADPKAPVQVKLVSRNMSSLTKLKAAFDRLLRGEKVTDSGQTVWNDFFGGPAGQNFLDDLEKAHPTVRINRDTRRRTLALFGPQADRAHVNAEIVTRAKLLQAQRKHRYSVASHLIGVFMSEDLPSLQKELGRENVWFDLTNRQLVVCGDPSTQKVARLVVQQAGKRQRKRNSRGDAGCPVCFGEVSQPVSLMCGHTWCQACLVGYMHASVDSRSFPLTCLGDEAKCTHHIPLSVAQQLLSPDEFDAIVNASFLAHVQSHPDEFHYCPTPDCPQVYRKSGPGAVLQCPSCLVRICSHCNMEYHESRSCQDQNPEDERLFERWKLGHDVKDCPSCKVPIERMAGCNHMTCTSCQTHICWACLATFSTSQQVYSHMRSIHGGIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NT51</accession>
    <name>A0A4Q9NT51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nep1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_805853</name>
        <name evidence="12" type="ORF">BD311DRAFT_661751</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143415">
        <property type="protein sequence ID" value="TBU29107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NT51"/>
    <dbReference type="STRING" id="114155.A0A4Q9NT51"/>
    <dbReference type="OMA" id="RMAGNAN"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU29107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU65171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="302" mass="32884" checksum="6C02D9B88571FE83" modified="2019-07-31" version="1">MQIDRFSASHSPTAATTASLHNSAVLADSKVNERPTRPLPSSSKARKMQQQQTSNNPLMQQANPLMLPVQAHVAKSGPASTQRKLYVILEQACLEAYRVSTAGRAKNGREGDVKYALLNCDDHQGILAKTGRDIADARPDITHQCLLTLLDSPLNKAGLLQVYIHTARGVLIEVNPHVRIPRTFKRFSGLMVQLLHKLSIRGVNGPEKLLKVIKNPVTDHLPANTIKLTLSGDAPVVKLSKYLPTLPETHHIAVFVGAMARGKDDFADGIVDEKIGISQFPLSASVACGKFCCALEDLWDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW51</accession>
    <name>A0A4Q9NW51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_812483</name>
        <name evidence="3" type="ORF">BD311DRAFT_673311</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143497">
        <property type="protein sequence ID" value="TBU23721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW51"/>
    <dbReference type="OrthoDB" id="2745134at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU23721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="98" mass="11350" checksum="EC60D8A8513D6E1C" modified="2019-07-31" version="1">MASYEPSQETLDNVAFSNFGYYAVVAFLGYEYFITLDMEVALFWKKHTTGAGILFFFNRYYTLLWAVAEAATPYYTSPKRFAFYDCARTVHRSLTVTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NY57</accession>
    <name>A0A4Q9NY57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_815712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NY57"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="346"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU60340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="789" mass="87404" checksum="3589C853A029F298" modified="2019-07-31" version="1">MSPDASSDESWSSWSSFATTSDECCDESLADWDIVIPHYSKREYLLAQIRQKNAIIESLLKQIHNPYLATPMSIASYRMATSPTDQNNQNVLAWLDRLQASVQAAGTSAGLNAFKMDSRAEGHSGSDSDDDGGDGAAGEATERGSVGQAEDDEPLKDAEDRPTALPNEAVPIGLIAGLALDNKSKRKKKTPAKPKDGESSDDDVGVACETFFDPGPAFNLGLRATMIESVSPPEILVHGLVTPDDVEKLFKIYFERVNPHCDVLDPVLHTPASTFARCPFLFTVVCAISSRYYTEKSEIYPIAMHFAKHAAASALLNGWKSVELSQAYILMSLYGVPARRWEEDRNWLYTGLAIRIATDLNLHVVSNVRPKTEKQEREMVNQTRVWLLCFNLDRSTAAQFGKPSTIKEDYTIRHSNDWYKSSRMNSALDIGTSAYAQMLRVVSRFHEAIYSDAESPTGLNQRLDFRSVILEHDEQLTAYFNEWNERFRLDTDMTDPALKFRAALLPFLTGYSRLVMYSFGFQQAFKRGFQAEDHLFLEKCYESATTVIITFVDSLIPTGYMRTSPDGHFVFASFASAFLLKLLRPEFAGFVSRERQQEIFDLISRLIDKLGSPEVAIDERHTPALHSRFLHSLLRKHRRDLAATNRGHGANASQGTGALSQAQASQYTTLGGSGAAGASYESIAGSSPASFSDSSFTVGEPASPLFEVEPSYAAVNGSMNGQDGMFQFGTQQDESWGALMALQNPNYWKDMMMPGFSWPESPQSTQDHPMTNGFDNSFAYQMAAPIISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZ99</accession>
    <name>A0A4Q9NZ99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_620829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NZ99"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043960804" evidence="3">
        <location>
            <begin position="31"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="408" mass="44312" checksum="680D237239AF5443" modified="2019-07-31" version="1">MLRRAVSLGSSLPMLHVLSFLILSARLVVAASWSVAIDDTYGDVATGAMPIYNPPSAWTQGQACISENEDCLVDLDPKQVSNGTWHYSVGSSDDAPPRTIDLNFEGNSISVYCIISQVDRVRIAVVNMTFELDGQPVDTFFHDPSGTKDGAGNYDIQYNVAVYQSNLITPGNHTLRISSIGGSSMYFDYALYTTESDLHNPTMSALPSASAPSGTPATYAQNASSAHPRLGVIVGAAAGGAVLLIAIGILAFILIRRRRRAGEDLLRHRNDSLSKGGCRVYGRHDSQSDRRSIMSMDSVTLENHRASTPYFPFKDPDPFSPTSPSRDRGDADKTSVDVSPTDSSSLRYFPALSSSVDQPAPRIVVTRGETHLVGPDNSMARFARQTMVEREAELMRRMREMEAALVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P081</accession>
    <name>A0A4Q9P081_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Composite domain of metallo-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P081"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="474"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="994" mass="107823" checksum="37E0FF5D53FEA59A" modified="2019-07-31" version="1">MAGRDKRPTPPPLTTNPIHLESNLATPRWARSNLSQAWRHKRLPHRALAILLAALVLYGISTSRFSSESSYRAHPLAQRLSPDVVEDVLSRCAARDAAPRSPDNLLARSTNDRFEAGTRATLIKNVTLWTGARNGTEVVYGDIFLDKGLVQGIGYIPEWDYSKHNTDVVDANGSWVTPGLVDLHSHVGLVSAPVTAGALELDSPNGPVLPWLRSIDALNTHDASFAHAIAGGVTTVQVLPDSGHNAIGGQAFMIKLRKTSLRTPTSMIVEPPPTLNGSRRDPYDPRWRHLMMACGEGTRAYGNRMDNIWALRAAFAVARGFRDAQDAFCSRVEAGGWDETEGQGQAQTQTQAYPEDYRWEALVEVLRGRVKVSVQCNEAVDLDAMVRLSQEFKIPIASVHGALEGYLIPQILKGTYAGPPTIALSVDSSRAKREAYRGSEFASRILAENGLPIAMKSEYPARNGRNLVYEAQLAHYYGLPPNMALTSVTAIPAFAAGLSHRIGILREGADADLVLWDSHPLQLGATPRKVWIDGILQIDADRARVPVNKLKEDPVMQEAPKVPNFDAEREKAVRFDGLAPMRPNSTIGGRVVFQNVKELFTRERGDYAHFGLDGYEGLMNVVVERGRVTCIGNVCEGENADMVVDLHGGALVPGMMHFGPGLGVEEIEGEPSTGDGVRFDPLKANVPEVMGDVGALVRVSDALQFGTRNALVAHHAGVTYATTSFLRPASYARGSFMGGLSATFRTGASNALDRAALIKPATALHVAVGRSLPLAPSPGPSVSTEIATLRRLLLNGEGEHTETGKWFKKAANGEIPLVIDVSNADIMATLIRLKNEVEEKRGSYMRMIFSRATEAYLLADEIARNKIGVIISPSRQFPWSWDERRVLPGPPLANYTALSTLLKSGVTVGMGSWDASYTQGVRFDLGWAVLESGGQIKKKQAYELMTTNLEKLLDLEGRVGEMGELVAYDGGSALDFSSKPVAIVAPARGLVEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P0L0</accession>
    <name>A0A4Q9P0L0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_814901</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145103">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
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        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948:SF3">
        <property type="entry name" value="FI21118P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13948">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="593"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="69"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="730" mass="78956" checksum="856D6E95A638D558" modified="2019-07-31" version="1">MTHNREWDKGKQADYGGWQPPPRSNGHMRDDDWYGGDTGGNFKRRKYNDGGYDQSQGWDDSGYDQGSSYQDDRYKGGGGMYNKKRLVPSEPSPHVIFLGLDPDFTESDMQAYLTSNKCSIESVTIIRDRSTGTCPILLHSGFGFAQFTTTEHARAFVDPLFPFIQIPPPASHGATARAAFYRAVEQNIPQPPGGRRVKIDYSQSAAPGERRGPKGPLQSNDGTRDIGNVQAPVLLFRGLDPLSGPQAIAQAMKLSAGPGKEGAKGMRRIILIKDKVTTASWGFAFVEFVDIQSASAVLASTMSPQLHPNGFRISDRPVAASFAHPYSFQPIPDYSLRDEACVMATSTLGGVEGAWVRYWDEASTAAVLEFTVEEQAPSTSATPAPKEKKEKKKKDTTQETSVEASALPVSDKPVTLSFKGGLSIAKPGPAGPSKKAVPLSQAFSMDDAAEGEGDATTADATATEDPKVAASKRVAPLIASKKTVNNINKWNQVQDVLHHDAPQEVPITQPVETPAPVAPVAATQPAAVKAATPTETAETEFEFSDTKAMICLLCARQFKSLDQLKRHNKESDLHKKNFKDAALREVAREKVRAARAKAEAQQPKYRDRASERRVMHNQPDVPRPSSDDKPAAKRKHSEGPPPPEPPPAPPVNPGKDESNIGNKLLKMMGWKEGQGLGTEGEGRVDPIQTALYAAGAGLGATKPKDITKLASDYTGYVNLAKDAARERYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6K9</accession>
    <name>A0A4Q9P6K9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_943603</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="TBU66149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="114155.A0A4Q9P6K9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
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        <property type="term" value="F:helicase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="R3H_RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
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    </dbReference>
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        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RRM_dom"/>
    </dbReference>
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        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="489"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="35"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU66149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="539" mass="58137" checksum="04986498024EECCC" modified="2019-07-31" version="1">MTSSSTPDIAAQVATLSLGTQPSQQRLHDAYDYDGNSSGNGRSPYHYSTSPPIPAQSQYNPLGMNQSPLKNKASRAALPSQWLDNSAGIPDNRSLSPPNNSDLSSSGGSPPLSHMHAPQPPITPGTPAGDDEIIPTAIVIKNIPFNVKRETLLDIIASLAIPTPYAFNYHLDQSGQFRGLAFANFRQASDADAVVAALNGFDVQGRKLRVEYKKVLQAGEKERIEREKAIRRMRSMQLEKEQAAMQQQHQQSPYDEFGSVLSTPFTPQRSFSASNVYQSQQYSPPQMPPLPTSQSFNVSSPPLPSVSPGLGGGVKSSNELDLNDPSTLEIYSRILLFKDDPMRDELAFSRALTAKQRRVVHLVAQKLGVYHYSVGEGDERYAVVTRIDPNPTGRQTLSRAPASYLSPTSPMSAQSLRVKKSMPDMKSLQQAAPRLTTRSSNGNIREGYATIASPSRRSPGFAALFGNGAFGGNGIPPVPTLPASVSGLSGAGGGMDSPTGVVRQPRGPGVGGFESRRERRESQTNRGGFEARSHEPLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P805</accession>
    <name>A0A4Q9P805_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_802571</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P805"/>
    <dbReference type="STRING" id="114155.A0A4Q9P805"/>
    <dbReference type="OMA" id="LIRECKM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="389" mass="43482" checksum="6983D9DD95F46DD9" modified="2019-07-31" version="1">MDGPLKELSRLEKLASGAPAGKAKAPSIDQSLDALLESLRNAKERFQNGTGSQVTLLSLAKTVEDKKKEIDERQKEVYNALAKVGKALDKKFTNPLPSYEPLFQSPEAKLALERTIAMHFLRTGGFETAETFLGESNVTISPEHRVQFMDLHRIMTALRQGDIAPALEWAHCHREFLQKRNSSLEFHLHRFQYLRLVLSHPPDINAALAYSHAHLAPFFNRHRVEVQRLLTCVLYLPLSKLLTSPYADLADPSVHSDLQSMFATEYCADLGMSRQAPLRVIADIGGGGALARIEKGRKVMRERKSEWSQTDELPVSIEIPLPPENRYHSIFACPVSKEQSTEANPPMMLACGHVITKDSLTKLSKPGGRVKCPYCPAESTIQSALRVYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8V1</accession>
    <name>A0A4Q9P8V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_835584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145443">
        <property type="protein sequence ID" value="TBU51019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="196" mass="21310" checksum="4B6545A3DB62C893" modified="2019-07-31" version="1" fragment="single">RVQYSRIHQYISLRVQQSSRVKNEGQQTRTAAAAANKSPYTSGAYLTRDSLSVRHHLVRLAPPRLVFLTKSGSSSIARTAITLVSAPLARSQVPGSKTAPHVPVPTPSQRRQPASAERMKYTPPLHSPASIPSSGAPHQPAFPSSLPATSASLPWLDPRLKTRERLNTPRQSRRSRSPSQTASRTGTPHAFVLSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9I3</accession>
    <name>A0A4Q9P9I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_921045</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9I3"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9I3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072357">
        <property type="term" value="C:PTW/PP1 phosphatase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46557:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="133"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="435"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="556"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="915" mass="98168" checksum="949706641788A6E7" modified="2019-07-31" version="1">MEYTNAAWLQTQIADLQTVHDERTSATPDDWKEQAASVQGGINDLLGDIQVSNTSTASTNSPGPTFFLPYPLQLLSTTSPFNSAPFGASQWQASSSQQVPVSSYSSLNGATAASSHLQSQGHSVGAMVIDPALTTMNGSSGSPPQQFQQPSFMSSQPQSRMQFSYQQQAHSSPLSINPSYVHANASHYQQPQQQHSISLSRNHSHSPSQQQQQQQQQGTLSPFVLHSPTSGFYAGIPPSSFYGQSLQPQAGPSSTPQPPPQPSQPAQPPPSSASPPAPNKPSPEQRRAKLAQDVKPFIQPTSFTGAGAVNQLVNILDDYGIPEVEASLRLEILTKIRDNAGNHYFRAWVDNTVALDIIREWLKLAFQGRNEPQLLETIMPILHIIDRLPLTVDKLKTAKLGKLIMRLVKEPPTPAIKDMAANLEKKWRKLLAQEVSDKMDTENPEDKNKKRRAEGIPAKGAPPVKKAAVPGATASTPKAIPVKKEAKPVVKDAKSDSSFFSKPKVTKKELPSFKKNAPAAPAPVKKESDQNIAQPSSFNPFEEVLKSYGSAGASATPPPSVPSPAPGPSTTVASVTAPSGLTRKGKLKRSVTWAPDGQLEQIRLIERAVYDDDPATGSHPAHNIRDLDRDEGAALHAVLFDEQIEWAEPQPLELPPEIQIPPRGNDSQERAAQEEREQNALLVLYPSPTQIPDSPAEPLTQIAEDHVDEGMVLMLTGPEVDAVLWNASPPPSTPSAVADLVAQLASGSGGDVLMGDSGQAAAAVSNMYTNGDGFDAEKLKHLMAQLQQSNPLATLSAGGLAPSQPQQGDSAQGWNPGNQYSDYDRGYHENGAGRGGGDPSRRWNDDGPWGSAPGGPGPAASERGFRGRGRGGPRGMGRGRGDGHRNTKRKPCSFFLAGRCRYGDQCDFSHEALPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9R3</accession>
    <name>A0A4Q9P9R3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU51410.1"/>
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    </dbReference>
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            <begin position="231"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="312" mass="34497" checksum="5B7C21309C6ECE17" modified="2019-07-31" version="1">MFTPPSQTDFVPLTGTPVAGFGHITLSFIAPLRTLVEEMSQRIVDFVRKCGGEKCANLHWHGVTMRNALSRLRLMPASFPDQLLQVTELQRHWLMASAYLEYQWRLRSVSSADETICAHLPLMGAWSSEPQHVQLLYGAGIPVWYVRTSHILHREICIARSTTPVAPSTLQLARFPGTDGCLFHGLVGEAHLHSMMQGGHGYLDISRVPTASIYSGEDYGPGITIREAKAVGRAGGSASGSRTARSSQSHGEHTLSQRSLRSKPYDRRRVPGPHPSQVHGHDKFVEFPHKWMPPAVAATRRVDSGRRSVTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB89</accession>
    <name>A0A4Q9PB89_9APHY</name>
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB89"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9447" checksum="08B6718A071FE0F6" modified="2019-07-31" version="1">MPLAELSYPISIEISNYATVAIIVVVIYECLITIDREVNFAWNGWSRQVSWARCVFLLNRYLTILLCVTGCIQISSTFKTALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
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    <name>A0A4Q9PBF6_9APHY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="317" mass="35193" checksum="F603D08396A941E9" modified="2019-07-31" version="1">MNLPMAITGESSYGNDYTEPPPAYDIEQKLDQKPDNKKSSWTDDFHPSPDPLRSAPGSDLFYNGYAPTHIPSSNKHPSQVGKFAGGKSTQKLLNPPPACFSRTPPSDQQYPEFEMITIPSLGHQYLAKGFPATLPQTATRPHPFSTHDVTEEDWMHFLADLKAAGSLGWSDRIVSNIAPALLGTAFLPALLLSEGIERKQKMKKRGPVMELIQNWNACYWNPRYMEVTVVQAGGTIMAPSPMVQPYMQSARPGSDVDIPNSIHGYSHERDEPHDHKDKTKYPGQLRPSGSSPSRPSANLRGSGWFLHIAYKHHGQDH</sequence>
</entry>
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    <accession>A0A4Q9PBK2</accession>
    <name>A0A4Q9PBK2_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <lineage>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10034" checksum="7565123E7390B741" modified="2019-07-31" version="1">MQARLASLRQLLSCKTTGSRSRTASGFPSVSSWTPRRALIGRPSYPSYTSVLGPPLFHRAYLSSWADRRLHRARLDPLDAPSLPPRAPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD12</accession>
    <name>A0A4Q9PD12_9APHY</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD12"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <position position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="152" mass="17067" checksum="140F3A9539D64B8C" modified="2019-07-31" version="1" fragment="single">MGRSPWSTQEETKWLLEQLPGFRVARANETSAQFLNATYQGYFDKFWPGVLQSSTVEISKDGSGEVTGPGGVTFKKRKDQIYWWFWNRQFGKTGVKKAKEGLDLTPKRPPHVGIQVPGALSKRLHTPGNALPPRSLPHGLTIVRLDKDHPTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDA1</accession>
    <name>A0A4Q9PDA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
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    <organism evidence="3 4">
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        <lineage>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145235">
        <property type="protein sequence ID" value="TBU52824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDA1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDA1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="111"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="286"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="813" mass="90474" checksum="27CC3058EF8A1ED5" modified="2019-07-31" version="1">MRLLDTETGRFVEVANTTGVRYAILSHTWDPQGEQTFAEVKEIQKSYGISRPYIPSPQELPPITRNRSHSFRSYRDVSLTSSISPISPVSPTSPLTGSDDDSTVDSFWDDPRLSSKIKQACSVARSHGYTLIWIDSCCIDKTSSSELSETINSMYRWYRDSHVCYAFLSDVVHGGNPLAQDSHFRRSRWFTRGWTLQELIAPRVVVFLSQEWVAFGTKATLATVIEEITGIDVVVLTLRRSLDKVSVAARMSWASKRITTRDEDRAYSLLGIFDIKMPALYGEGARAFIRLQEEILKRIPDQSIFASGSVSPSLFPLKSQVPKLTRQGHTSPHSSRFVRGGSSPRFGFQSFEPDAFPPITASSLLATSPTQFKSHHHACIPLSYGDFILRLGRPDMDIPIPEYTHSSYGIRTQLPLLRIADCFDTTLMESYDSSQTEWYLAILACRLSSPDGYVLARICSVHRSVSGLKFLQYGCVHASNLCSDDTLVNGTPRWHLFSFSQSDMEACRRHLRIETVYLPYDVPEESFLPVSLLAKDSYLFFGDTQHVTISLSSLAHAVLLGQGYRVDYRDPSQYKPCTYYLCLAKHRSSIHIELEFVQDEGFFGSFRVTAWVVDSPDDPEATAVGSSPWTTRRTVAWADGAGIPDIELKTAKGNDIVVSVTLDELLEPGYGSYQLGVEVSDLSLDDDPPSSTTEATALLATEGAGRREPAGSNDADRHAAVGIVMHKTLWEEDGGDIRRRQQVKEGNTAYVRVCVVVGPQGQDNWGFGSPSASPRTFASPLVPNGPTLFVLFPLEQYHRCGFLHFDNPGDLNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDD4</accession>
    <name>A0A4Q9PDD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_981687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145241">
        <property type="protein sequence ID" value="TBU52668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDD4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="42593" checksum="A41FF76043B6BA6D" modified="2019-07-31" version="1">MPTLLSLPPELLIHILDLLSSDVWTLRNCAYTCSALRPFCRHHLLAVADFNVLGDADAEPFRDCITHLQISVKSGGLDGIPETHIEVALRLPKLKKMSFCGPSNPFRHWFPTGIQEALHLFSSVTELALVRTTHASVEQLQSLISSLNNLSHLTIHGLTVQGSVHGNYFARHQHRHAEELGGPRLTHLNAAPSFHADGTAAVLQWLSHTPTRHCLRTLDIPAASRNTQFVVDSFGPTIHRLCVAELKSIAAWKTSFIHRYTNLLTLEVGSLSQLSWQPLYKVVAGICSPDFCELVLRYDAVADADARIAASRVETSPVDYILHDDMPALQKVCFVVQYDSRLAGRDAQWKDAVRERVRSFFYRLAEDGTLQVEFEAQRIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFC1</accession>
    <name>A0A4Q9PFC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_491194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145521">
        <property type="protein sequence ID" value="TBU50966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFC1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16636" checksum="26327DF3F7FA60E8" modified="2019-07-31" version="1">MRPVHHPRRQSCVVRRQTLSDETQETPCPRPPQAGTAWAVNDRHDQRTGGLHSLDSDVSAPTRQYPAIMAAEVTERSTGRPLQSRLHQALPLPSVPLASIFASSVRSPPVHQTCCLPQCAHRRFHDTARPWARAPTSVLTTRHQQQLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFV3</accession>
    <name>A0A4Q9PFV3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Synaptobrevin homolog YKT6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_890248</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the synaptobrevin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145279">
        <property type="protein sequence ID" value="TBU51892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFV3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFV3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15867">
        <property type="entry name" value="R-SNARE_YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000020">
        <property type="entry name" value="synaptobrevin homolog YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045848">
        <property type="entry name" value="R-SNARE_YKT6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU51892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="12271" checksum="650EDD3888774421" modified="2019-07-31" version="1">MPPIQVFSLDDFIAKVAQASFNTPAAISFPEINTYLQKYQDPRQADAIMKVQQELDETKIILHKTIESVLQRGEKINDLVDRSNELSMQSKMFYKTAKKQNSCCLIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG59</accession>
    <name>A0A4Q9PG59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1043187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145262">
        <property type="protein sequence ID" value="TBU52197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG59"/>
    <dbReference type="STRING" id="114155.A0A4Q9PG59"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="385"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="554" mass="60589" checksum="A728A81747911D51" modified="2019-07-31" version="1">MDHHSAYINSAAHFNSSLSSPVPPSTHSSIASIETSLRLQRAEQDLMDLRRQFVELRVQVEEIKRDKTSKAAPEDGDDSRGTPSTHLRRTPSSALIATLKRLVFESVKATHSLKPGEPLGYDCVREQDDFPNVKFFTERQWNKWKRDNKKTTRIGETVVRGKKMSAQGVNHTAPYVEYPDGTPADGDYINDARKFCRTLINLARGAQYPLPRKWGDTDVWLRELFYTALRKKFPLFQLCHNNAKGDSFMYYSYYETVTRKWDNGSSQPIDLNQALHTIPSQSDLEESESESVRRGEVRTTRPSEKATPAKRPSGDDIIVVGPRKQARTDAGVPQDVAPPQSVEPPPAASKSFKGKERAAPSLLAVIAPSTSYLQLVQRSPSLVASPRSVLPPTSTSPTSTSASQSGPSAPPSMATSAQATQAPPALSPLASLTTLATVSGAADVIPSPPTPTDPDIPAEGGVDISASPPQDVTSTGTAPSNERADKPSEVTASKKTRAPRKTTQWPPPPDMKGAKWFYARKWYADSNGTLEAFEAHYKTLSASDRRKLGRVSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGD9</accession>
    <name>A0A4Q9PGD9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UvrD-like helicase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_830117</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145214">
        <property type="protein sequence ID" value="TBU53445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PGD9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039904">
        <property type="entry name" value="TRANK1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529">
        <property type="entry name" value="MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21529:SF4">
        <property type="entry name" value="TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="6">
        <location>
            <begin position="748"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="196"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1610" mass="183078" checksum="AD72DFF05B7E43A7" modified="2019-07-31" version="1">MSHSTTADMISDVHDIENALYNSFSDLESVIGRLMGSHGRAESALATLNDATFSTFTREIYARFPKTARQFVGSLSSFLLSSLATALTDVSQQGKLGKSRDSNECWKAVVLARPALAEIASLSDNSRWSQADIRVKPFVDLGVDPPSNPQELFALETQILRDQEGILKHIFSLLRGPARDDIIARWHALAEMETVVDSARPESSGSDETATPEAQPESQTPINAHPALDVLPLKAAFYEDHVKGFGEWEVFITDNANSDFRKLRKKSPELLRVVMKKIRDLSRGHFSPDNQILISDTENSVPIFKAKMTGVSRLVYQVDCVKDLVSDAYIALRIFGVYNHAELKHKGNFWVELSRDLGRKGKEYRDRCRARSQPTRTARDVFSPVKFWLQSEEANKGEDEPLPLASLKDVDYSEVLSMHRSVTLSKGLFNSFLVDRDIRFMFRPSTKEIEIIEHPHSCYVIGRSGTGKTLSMMYKIVSRERGWASISAELPKPRQLFVTRSRMLAAEVQRTVDHLLESFKLADLTQQELLDIWRRQVDPMDEIRPLPRKWSDLDDEHFPMCISFDQLRDMLEADFAACDPSMATTIGELGEDIDFEEHAASFVSWKRFATAYWDHLPQHLTRGLVSVFGEIMGVLKGSEGTIDTPHGNLDREAYLGLSPRHSTFVSIRNQIYDILQRYNLLKRRRHEYDDADRLINAHTLPGRPVNFLFNDEAQDNLIIDMLRIIVRDDASRKRLFKALFSQGVQVGLVMTVYESKGLEFDDVFIWHFFDSTDPSEREWSVICDLFLGRLTRSLHRSVDEYRHLKSLYVAITRARNRLFIIEESSKGDPMLAVWQKLGLVDVNEDNQPISLSMKTPEPEEWAKRGRSLMDKQNYEQAKYCFEQAGFRREGDIAQAYLDQEAAVTVEQFRKAAQSFKSCADLCFGVAEHEQLLIASAICYSRAGAFAESAALYYTARAYTRCAQQYIKASMMDEARQVILRHRNEINAYVLRKVCVHFLDSGEQEKAAELFPDLDTFSEFIRSHNLIGHLATYLESLGLLEKAAEVRLELNQVDKAIALFLRDESHGSVARGTNRLLDELWRLRTMGQPENKYSNVPDVLIDLVSYRKSLTGLRYRDYERDNNETHMFSSIISRQAADLMQTGVKLFSVGNQTNAALLSLDYAFAFLLEDASLEPSVLVDSPEFFPAFCTYATLLKSHHPYGTLDANDDAIWRERTYWMYALSSSLHIPFFSLGTPSMFHRSLVPEFSDAARVIRSWIIDILYFAFTPASTHWISTGALRIDLIPCAALLGYILDKLEDHPRSPQSRVVPIPLELWYGKLYSQHLQQLGDYASRNEPSHFQMPGALLYLQFLLEGGGGSFGREAVISYITEGLSTAIVLANRGRKDKPLHNVILVRRWVINLADLWSSAKPPTHHHNEHVQKFIKLFPALLGSLCAVPDGASIRRVLRPLSNDILSYVSSVVKALTLVGHWLKHTEEERLEMVGYVTNIPVHYRPPHLRRLSAGSRWTHLREAIWWQSPPALPRMDQLVHIQNSSLADTDPMRTPGFVVRVAYDRLGNLESQLTVPQPTRQAAPFPATWFLPRRHPLDGEKVVVPSHIAPCLLGHLWPQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGM8</accession>
    <name>A0A4Q9PGM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_981822</name>
        <name evidence="4" type="ORF">BD311DRAFT_764715</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143462">
        <property type="protein sequence ID" value="TBU25397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145248">
        <property type="protein sequence ID" value="TBU52507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGM8"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="3">
        <location>
            <begin position="31"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU25397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="381" mass="43123" checksum="1A047DD5BBD90F1E" modified="2019-07-31" version="1">MSKIWIPAPEPPTKLGRYRQLSPLAGVRVSPICFGAMSIGDKWEQLGMGAMNKESSFALLDAFYEAGGNFIDTANNYQDESSEEFIGEWMEKRGIRDQIVVATKYTTNFKRHAEDIKQKVHYTGNNLKAMHISVEASLKKLRTDYIDILYVHWWDWDTSVEEVMNGLHNLVTSGKVLYLGISDTPAWIVSKANLYARLTGKTPFVIYQGAWSILQRDFERDILPMARAEGLALAPWNVLAAGRVRTDEEEERRRQTGELGRTISRPAWERTESERKVCKALEDVQRQVGAKSIQAVAIAYVMQKTPYVFPIIGCRKTEQLQANIEALDVKLTEEHIKFLEGVLPFDAGFPSTMVGDGTEYILLARSAGNFDKWPRAQAIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGS7</accession>
    <name>A0A4Q9PGS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_861774</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145247">
        <property type="protein sequence ID" value="TBU52532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGS7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGS7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045035">
        <property type="entry name" value="YSL-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31645:SF0">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER YGL114W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="287"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="562"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="681" mass="72760" checksum="B89D5A7D4BE551B1" modified="2019-07-31" version="1">MSIAGCLRRLRRRAHHSADTPSDGSQADFTIRAVLLGLLIGCLLCFTNLYFGLQTGWISMMSLQSALIGFLMSKLLRKPMSAQENVVLQTTAVATGTMPLAAGFVGILPALGLLDEKRDGVPPMHLSWIAAVGWSCAVAFFGVFLSPPLRKQVIIEEQLAFPSGTATGQLISVLHDMPPPETSLRQRRGYNALASTDDDDGIAYVASEDPRVSDALRASEPVPTEVPVVEEREGWSALSWSFAASGVMTLLAYFFPAVFSIPLFGTYLASQWMWTFTPSLSYVGQGIIMGFPTTLSMNLGMLVGWGILSPLAKHSGWAPGPIGDMTVGARGWILWVSLAIMCSDSLVSLVPVVVELFQEKVWRALRGSVDDVDSVKESKEVETEDRLVPMSWVAWGLAGSVILGTLLVWLVFGDEGIKPWATLLGFVMGALLSVLGVRALGETDLNPVSGLGKISQLFFAWIQPGNIVANIIAGGVAEAGAQQAGDLMQDLKTGHLIHASPRAQFFGQLIGSCLSIIVTTTAYTLYQRAYEIPGPSFPAPTAFVWLGLARLLRDGELPERSALFMVFFAILFGAVAAAKTYAVRSGWPHAKWIPSGVAFAIGFLNTPSFSLARLVGGIVEHVYYTRVGRENGGIKLIVIASGFVLGEGVVSVVSLILRTFGVGVASCWGCGHGMCGGCPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH00</accession>
    <name>A0A4Q9PH00_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_997311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145245">
        <property type="protein sequence ID" value="TBU52581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH00"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="375" mass="40650" checksum="FA3412E6720969B0" modified="2019-07-31" version="1" fragment="single">NHVHNTYPSSNSLPPSSILALGIVVTPPVTSQDDPRLLSPPSSMARCLFSLARTHPLEATQVNHSWLSKSSAAGRSRTSRTQIYRCHPTLVFLLPSPFSRLALDALAFLILVIRPSLQRVSLGLCRRCAGRHHDDDRRGPSPDLGPSSTTTAMRKPPTHIPIAHTCQIRHTRGPFELESEPAPAELGHSSLAQLSHQAGCLLPPQTHARRSLSNTLATSRTRGDQPLPHRPQPGPRRPSFFLLRFAFCILHPDPPSRRRTRPLAGSRPPPSLLFRSSGDPPIGCRWARTVHGDPTPLTACDRCTACGDARQARSRGDAAVSPSRVLSLQSLHLHAGQRSRDDTTAVHNALMHTMTPLHPTSAVLDSSAGGGGGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHH6</accession>
    <name>A0A4Q9PHH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_788011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145221">
        <property type="protein sequence ID" value="TBU53217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHH6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="120" mass="13411" checksum="2AF3293BF4952C22" modified="2019-07-31" version="1" fragment="single">AELFLPEHLRLGADNWPEFELAIETVLRLKGIPLGHLRCAGCPSGSARPRMPGPVDGADGDGWAADDELCKTLLVLNVRSDHVRLAGRAHDGWTAAQMWALLVRRHEESERERERKVAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI51</accession>
    <name>A0A4Q9PI51_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Palmitoyl-protein thioesterase 1</fullName>
            <ecNumber evidence="2">3.1.2.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Palmitoyl-protein hydrolase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_937379</name>
        <name evidence="10" type="ORF">BD311DRAFT_754937</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palmitoyl-protein thioesterase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.22" evidence="2"/>
    <dbReference type="EMBL" id="ML143407">
        <property type="protein sequence ID" value="TBU30203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI51"/>
    <dbReference type="STRING" id="114155.A0A4Q9PI51"/>
    <dbReference type="OMA" id="KFVMVMF"/>
    <dbReference type="OrthoDB" id="10263094at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000107">
        <property type="entry name" value="Palmitoyl-protein thioesterase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002472">
        <property type="entry name" value="Palm_thioest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247:SF8">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11247">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02089">
        <property type="entry name" value="Palm_thioest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00414">
        <property type="entry name" value="PPTHIESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597635" description="Palmitoyl-protein thioesterase 1" evidence="9">
        <location>
            <begin position="21"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU30203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU53787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="331" mass="37463" checksum="18865A67292E96CF" modified="2019-07-31" version="1">MANLLFLWISLLALTSFGISTPVRLTDPSRRPLVIWHGLGDSYASAGMLEFMQLIKDIHPGIFIHSVWLNEDLEQDQKAGFFGDVTEQLEVVSEQLAEIPELQYGFDAIGFSQGGQFLRAYIERYNAPPVNNLVTFGSQHMGVSDLPLCSRWDLFCQLARRYAARGGVYTEWAQHNLVQAQYYRDPAQLDLYLNSSRFLALVNNEVPEHINSTYADNLATLSNLVLVLFSADKTVVPKESAWFGSYASSNGTGDEKTIVPMRLQPLYTEDWIGLRTLDETGRVTLETCEGEHMQLKEECWKPLVERYTGEVVKDESDYRLVSDGTVFQIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIJ2</accession>
    <name>A0A4Q9PIJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_138641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145209">
        <property type="protein sequence ID" value="TBU53626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIJ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="612" mass="68369" checksum="4EF6897E48BBF1A8" modified="2019-07-31" version="1">MPDAIDVKDVQRDRTQSPPVGRLPPEVLSDVFDLVRRGHLDGMKAHDGAMLVPPDNRSLIVVTHVSRQWREIALQYTTLWTDIVITSPTAATFLRRSRRLPLTIFVTGEREELPPLEEWRSYDLHVRIRGLYIELEDHSRINSWQAVLQILADSLEGLTIVIKRPRRRLIWTTSLALSLFGSKCPASLRSLSISSRMPIFPTDHFPALQHASLSEFDCFPIRLELLAHFLLNAPALQTFHLHIHPTSRRTHSVHPDLSPIVLPCMRRLCIALPLFRFDPMSEVAHIAVQAWLANLVVPKTAAVSLREAPYANTVSCSDLPLYLPPTLGPSPTSALSIDDQGTAYACSGNSQTIHFAYAQRLAPERPGSSAGLAARAPLRAQMVRALGSVRILRIQSPWDAHRVNSVYQDSLARLLPYMPHLTELVVRDVDGETLVQLVWMLTRSEPVLCPGLASVTYITLGASARHLDAQGSATRMLFEAGARRALLGRAFKRLTYCCPENAQELTLQNAHGVEQILVTNRDVWAEYDCAFDEEARGCCAAHMRSFEPTRAPGRPESSAAYASLWKAKKDVCFPEPPPTFTAWNKLLLVCCASCLLCLWVLFESTRYASLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKJ8</accession>
    <name>A0A4Q9PKJ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_935267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKJ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKJ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="311" mass="34759" checksum="EAA632DC17DE405F" modified="2019-07-31" version="1">MQLRHVLMVDSAQKLGSMSATDTITVPLTAQHLLDVAKEVVLSTSIMCTWGRCHAELNSWKSLQEHLHRHCQEQGPSSSQGIWECKINRCVGRYHGTLPALQQHVNLSHLSRVALPCPIRGCTSSFGRSGNGLSAHIQTTHFDVLSMDTSQSFHQLRRPHPHPREELSALPAYPVPVYKLLCPTVRPARRGKTPTASQGSRRKWRRMDTQAAAPPEEDDDEDEPAIPLADLPPIDLCGCPEIHDYFVRPKPPESWLQLSRPQQVVDPPVPEKPPAPSIGYDAFAARFEQLERAGLIDGKGLWPEEGWNKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKN3</accession>
    <name>A0A4Q9PKN3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_885618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKN3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="405" mass="44691" checksum="84F97AD28B092619" modified="2019-07-31" version="1">MATATITRLSPTMPSQGSYDYLYQANVGLQNLHSVWAHGPRAAAKENGPTLKRAKTSTSFYDTSSPSAVDFLAIGLEYRLACALGRKTVQIRDRCADSPAARLSVCSNLSTSGTNEPPGERPVLEDWTSDYVFDDNVDPFAVAEVERTTALNPHGTAESETSRSVGTLIPERPSLVALQPSCIEDTRPTPCDTPAGVKATTLLKVHAPKAIRPTHQFHPDQFHPDLSGRSWRAPGPSPLARSFSANASATDARDQRHKDEDEGDFARSFNRHHRLSPRLRIWPLPRSLGRKDGSARIPTPLLRELQRSHFLSQVCFLDVEAPELDFVDERSMEWLLDIQADLLSGRITIPGVSRFALAEPPRLGTSHRCLKWVQGSTFPRRVKDYGKAADDMLARRRAKNGALIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLG2</accession>
    <name>A0A4Q9PLG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_826807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU54984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLG2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLG2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="421" mass="46659" checksum="3B3CAED59D9DD5FA" modified="2019-07-31" version="1">MAPLRLVTTNQSSHQSIRSPTHSVSTSEYTTEQDTVQVQDTDFELIKPTLPLSPFGGSFESLPSPVRPGFLRTDSPALSDISGHSYPHPASVSSSDIRSPKDEASQIEAHRQRELRWISAMSSISSSQARKSKKIRKMVLDGVPASVRYQVWATLTDSKGKRMEGLYQRLAQREKVAAYPEIERDIQSSFIAHPQLQDGSLAKLLQAYLSMVPDIQYSRGLALVAVQLLLQSPEEDAFWTFISLMDSHLRPYFSSSNVQLEVDASLFAKALESNDAASAKKIFGDMAISPVIVCRAWFTTVFADALPSDYLVRLWDVFLFEGVTFLFRAGLALFSCTRRLFLQSTSPEAVLDILSRPPSTSLPPSPNAFIELAFSMKFKDDDVRKQRGKLEAQVKRRTAQARASPISPAITPTISLPKSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNL2</accession>
    <name>A0A4Q9PNL2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_979297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNL2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="254" mass="28664" checksum="53024094CB2EB618" modified="2019-07-31" version="1">MSNSKCSICATGIVPAGLARSAPMSCATGDICYLRESLATPVEYILQATEVIRQDPVALQRSKAALRDLRSRSIGKYRPCLLVRNAIPGARPATEFLMGTLRREPIESPSIPKVYREFCRAIYPNSGFLDSAHFHTTPPWPHSSQWLVSYPIPLGDNNLVTVHWRFKDESTPAQVYAMDKASLEALTVHSRKTFKEWQARCNKEPEFARAVETEWRVRSAALRPRRRSISDKYLHGSELLCFSPTIATYHSRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNZ9</accession>
    <name>A0A4Q9PNZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartic peptidase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_950463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNZ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="73"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="41944" checksum="EA5F570442EE1F8D" modified="2019-07-31" version="1">MSVAALSPVVVRDSLVTLPLARHINTTASRNIVAHDQARVKVLRSRSQGAAGVISNLRKGPDGVPIQESFDVYTVDVQVGTPPTTYTLIVDTGSSNTWVGAGTPYEQTNSSVDTGDDVVVFYGSGLFEGEEFLDTVSVGSLTIHNQSIGDAEFAFGFQGFDGILGLGPTDLTEGTTSDGNAVPTFLDNAFAKGLVQEKTLGISFEPAIGNGELTIGGTNRLKFFGELNFIPFTSTSPASDYVGIDQSITYGIGRGATTIMSSTAGIVDTGTTLILIPSDALATYQNITGAVLDEDTGFLSITKEQYDNLESLFFHIGKNTFEITPNAQIWPRALNTAIGGQAGSIYLILGDSGVDTGSGLDFINGYAFLQRFYHAVDYLGERAGFAFTEYTYATSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP15</accession>
    <name>A0A4Q9PP15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_641676</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP15"/>
    <dbReference type="STRING" id="114155.A0A4Q9PP15"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="246"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="704" mass="79015" checksum="9FC63E202FB2F520" modified="2019-07-31" version="1">MPCSPEILPRIRLYVRNLFRRYIACSASIAESESLDHQALTGSPTHPPEPNEGKQYCQIDTPSTSLVCDFCWEGLFAQGPFQRAWTLQKTPHPGFSQKTTWEQVEVSSHRGCQWCTLVLATRTPGAAHQETVRVTIRFRVSSTNNGETPEGIQMMVLVIDGEPHSSYYIYTSRDNPAAPFIVARDRLLQLNSSYAIAMAQESLMNCLRNHQQCSTAHVSILPTRVIDCLDPRNLKLYVSNGEKAPYVALSYVWGEPQSHRTTTENVDAYLRRIDSSLLPQTTKDAIECTHAFGHRYLWIDSLCILQDSEEDKAREISQMCSIYRHAYFTIIAASAPKVGAGFLQERPPPSSDEVTLPFRCPDGSVGTMSLSPVWRQYDGSTEPVNQRAWCLQERLLSPRALVYASHTLQFHCQTSIVNVGNAVCGPMLGQRLPEMLFRPDSRIPSPLSSRDLKMLRWAWIETVGDYSQRAITEPGDKLVAFAAVPELFARAWKSEYLAGLWRRSLTQDLLWHTNFETRFARPSKYRAPSWSWAAVDGHILTSSMDDRLDPQSGETRGCDILGCDLLLATPLLPYGKVSSGTLSVRAVMVKATWNPESSMPDLYLPTDLAPEASQDVLFPHASPVAQVERMHIGCAYPDAVEDVLEIWAVPVLWNGLRQYTAGLIVTRAGEGDQYRRVGYFHSPEDSPAGLSWMLSQDRREIVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPK6</accession>
    <name>A0A4Q9PPK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Queuosine 5'-phosphate N-glycosylase/hydrolase</fullName>
            <ecNumber evidence="6">3.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 6">Queuosine-nucleotide N-glycosylase/hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_968797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the hydrolysis of queuosine 5'-phosphate, releasing the nucleobase queuine (q). Is required for salvage of queuine from exogenous queuosine (Q) that is imported and then converted to queuosine 5'-phosphate intracellularly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>queuosine 5'-phosphate + H2O = queuine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:75387"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:194371"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5 6">
            <dbReference type="Rhea" id="RHEA:75388"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the QNG1 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.-" evidence="6"/>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPK6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019438">
        <property type="entry name" value="Q_salvage"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314:SF0">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21314">
        <property type="entry name" value="QUEUOSINE 5'-PHOSPHATE N-GLYCOSYLASE_HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10343">
        <property type="entry name" value="Q_salvage"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="435" mass="49242" checksum="410C541CC4931502" modified="2019-07-31" version="1">MTVTLGSRPLEQRHADLAAYKNTNLQEASAFPAERSAYEEGVAEGVNPVLETSERAIEELDLVRLNEHGIKSAAIYIHYQMQRGSYLPRTWRTHPLHLCPADPFSWDDPSTLACLNWIFFISSLNFSFWSELEGQPGRYGVEWRDGWGEERTVVHTGYWSLVAAVDRALEEGIPITDPAFYASEGCCTDSLIEHVFRPASQSAETIPLLRERIAILREVGTILCQEFGGSFYGFVQAFRRRYSDRGTALQLVKMVADTFPPFRDEHVLNGRRRVYMWKRAQILVAETWAAFYPEDASTPHPLFPAGPAIHELTMFADYRVPQILHHLRMLIYPPSLVKLLNSRTPLASGSPEELSIRAASVVAVDRVRQEILRIISDEESGEGQSGRAGEDAVSSVMIDFYLWDLAKRVEGRPEGVEGIETDAMLPIHRTRSIWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ27</accession>
    <name>A0A4Q9PQ27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Surface antigen-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_613444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ27"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ27"/>
    <dbReference type="OMA" id="SGIWRQI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="180"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="493" mass="53803" checksum="06463ECB169041C6" modified="2019-07-31" version="1">MADAEPTTPPLQPPLHDTSAPRDREPDAADIEKYRKWWEERKLRKLRGQYESALVQLSHLVNENLSAPLNIASVRVRGAVRTRESFLGSLIDPYLVPSPDEPQTLSTVLRKTKEMKSLLEETDLFSQVEAVIDRSRDALANPDDVDVVFLTREKGRYFLNTSTQVGNNEGGASATCRVRNAFGGAETFEANVAFATKTRMSFNASLSKPLTSNLKRRGEVAVFGMERDNSSFASSSEGVRGLRAVVRTGTLPTGSHEFGYEAVLRHISNLAPSASVSMREAAGQSVKSSVYHAWTRDTRDDKIIGTRGSYAKLFQELAGAGGDASFYKAEAHGQLARSISPGVTLSLAARTGALWNFGAKSYFSDRFQLGGPVNVRMFRMNGMGPHDGVDSLGGNLYWSAGVSLISDIPRKPHWPVKTHLFLNAGRLDVMDKSRPLIDNVISSISKPSISAGLGLVYKLDPIRVEVNFGVPLVASKSDGLRKGFQVGIGLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ69</accession>
    <name>A0A4Q9PQ69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_823761</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal targeting signal receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ69"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ69"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005052">
        <property type="term" value="F:peroxisome matrix targeting signal-1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016560">
        <property type="term" value="P:protein import into peroxisome matrix, docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024111">
        <property type="entry name" value="PEX5/PEX5L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130:SF0">
        <property type="entry name" value="GH08708P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10130">
        <property type="entry name" value="PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="569"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="721" mass="78746" checksum="1F80475D89E80E66" modified="2019-07-31" version="1">MSLPLLVNGAECGPSNPLQGLSKRFDQDRGIQQDQFGAGRAGSSKETFRSQYSAAPGVNQDAARFFAAAPSPTPALQSPSAFDLSSLHRNLPISHSPSAQIQSPMQSSPLQAGPAAWAADFLQQVPKQAAPSSLSGKAAQHQGMPVAMEQTASAVPRAASSGFVPGESSEVFLQVLPNRRPVLTKPCWTAAKWDQVFRSQEHSFSSAPSTAAVLLQSEAVTEKPSRAQNHDPDELARTAGLLLDTVQNETSAKFKNSAFMGLMRQLRDGEVIVEGNEMVQRSESAAGDQLTTDVKGKGRAADILGPGINGMQLPTPQRRVVGTPAEGMATTGEQSSDEAGTLRTEDPNDAYFRQENEEYMAMHAGLANAGQIPSSGFQPQFQHQQAEWDNLQRDWETFEATAHGLRPLSGYEFQVNNPYLSGETSRTRHHTAHAGMPQTLYDSVLEMEAAVQRDPSNATRWYELGVKQQENEREQKAVQALRRALDLDPTLLSAWLALAISHTNEGDRMGAYNAIREWVERNPRYATAVEQFRTLNPDAPDARTSEKLAKLMQCLMSIVRDNADGEIDADIQIALAVLLNTTEEYARARDCFTTALAVRPDDWLLYNRVGATLANSGHPEEALQYYYAALELNPGYIRARFNLGISCTNLRRYDEAAQHILDALSLQDSDSVRDPGGNEASRGVTSSALWDSLKTCCLHMQRLDLATLCDKRDLEGMSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ99</accession>
    <name>A0A4Q9PQ99_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_882689</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ99"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ99"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051485">
        <property type="entry name" value="SR-CTD_assoc_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140">
        <property type="entry name" value="RNA PROCESSING PROTEIN LD23810P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23140:SF0">
        <property type="entry name" value="U2 SNRNP-ASSOCIATED SURP MOTIF-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="193"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="5">
        <location>
            <begin position="403"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="CID" evidence="6">
        <location>
            <begin position="486"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="700"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="752"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="765" mass="85916" checksum="A66C364D8A7B1A40" modified="2019-07-31" version="1">MDKTKSRLAAFFDNDEEETSFPQKEVDDYKKNVYTQGTLRKSKREKEKEAAEAKRKEEEENAAKAYAEFLNAFQGEGSDRKKGGSTFVKAGHDSGSAYAPSKPKANMSRAFEETSMVCRSPSPPMAPPKPKGKRAMDHFLEEIKRRARRLLPLEQADREARLSRHATQGRSVTSIAAYEGQSGSKDRGDPETSNVFVANLPPHVNEQTLGTFFARAGPVGSVKIMWPRSDASLGPGADMTATRRNKNAGLSGFVSFMKRRDAEAALREFDGYDWGGSILRVGWSKAVPIAAKPMYVVKRSRSQSASRSRSPSRRDRNRDEEHHRRSRSRSPSYERDRDRHRSRDYRSPRRSRSRSYSPSRSRSPSRHRRSRKYDDSLSRSPRRRRSRSPVPQVLADDEVTEQFLRTVASEVKGHDEEYETTLREREKSNPKYAFLNKDHRRYRYYRSLLDKREPIEPEFDDEGYNSVYSTDSAEESERERGRKHVLGKLARRRFEAMLRALSGRRGEMARCMAFSLEHAEAAAEVADIIVSSLVVDGTPVPRKVARLHLICDILHNSAAPLPMAWKFRQEFQSRLGLVFDHLSTIYHSFPGRITAETFKKQITAVVDIWEDWIVFPPEYTAELRARLEGATLKTDSTPGAEQPATDVVKEAAPAFALKFKTSAFKPAEMAEAEETAAAAQSDDGEPMDEGSDVDGKPVDDVDGEPLDADVDGVPLDDVDGEPMEDVDGAPMDDVDGEPLGDGAPVNAREVDGESMEDIDGEPAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQD0</accession>
    <name>A0A4Q9PQD0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_907748</name>
        <name evidence="1" type="ORF">BD311DRAFT_741846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143482">
        <property type="protein sequence ID" value="TBU24329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQD0"/>
    <dbReference type="OrthoDB" id="2736594at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU24329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="391" mass="44018" checksum="84E5ACB127BB1029" modified="2019-07-31" version="1">MSKRQFIPIEIFELVIDFIEDEKALQSTSLVCKAWLPRSRFNLFRVVELNFPGQLDSLLHLLESAPDIAPIIKEISISENSILALFRPAMSIAGRFPLSLSSYPLVQPRRLTVHNQLWLPTRYSPDYLLELSRFSSITSLDLFDVSFTTVADFSIILRALGRLESLHANHVDCQRQLDSDTSASIGCELPFLTFLRVSSDYPTSAVDWLIAHNKFPSLRDIEISYEIALDDQNQGLGALWASTGSTLENLKLGIFKRAAGHPISRGVMEKQLNLSSCTALRTLRFDCRGVREVSSDWTWLIWLITQLPAGAKGYPLRSIVLAFQHSSHALASLHRFTAELDRTLSEPSWAGTLAEVVFELDYRLPADEDEDELALLEAFAGLRSRNLLRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR95</accession>
    <name>A0A4Q9PR95_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_881757</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR95"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="350" mass="38530" checksum="858EA49F68CC1C61" modified="2019-07-31" version="1">MSEPDEFLLSSAVSLSGVTPDIGPSFSLLIFMHYLCPAITSIVVYDWAISLSRECQLFGTGNARTFSAWLYFANRYTNLFSQVVVLPMYLRSLSPKSCTHIVLAMSITSCLSMIPPAVFNSLRAFALSRSWSVSIFIFGLSLVPFASVMIEFGYHFTGIIEPAVQGCGVTLAYPIPLIRMSTILNRTCTIVADTLLIALTWRSLRRGIFLDRCRTLTKTDLMGVLLRDGTFYFIALLTTNILLIIILQRPPLNLASGDIISPYITGSLSSTLISRFMLDLQEAYQRKTVILVPEDLLCSLAAHIGAADLHLADAPWDNIVEARVDAVAEPHDAVPSLRATQHGSQLGSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRH3</accession>
    <name>A0A4Q9PRH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_822566</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="137"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="276"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="483" mass="54335" checksum="44DCB858C16F9CD6" modified="2019-07-31" version="1">MAGTIVHVEHDQFRRELLATEDAPLVDYAASNPFSTLANAENLSGQAISEFFIQAVSTSEIMPGCCISPMMRGCDDPNDDSPKLQHAAIFRGPRRDRPCRFDQVVPISFYCHHPRADPFDPTQLRSGGETMNDYQTDIYDELSSSVELLFTAQHRVFLFMILVMGRRFRILRWDRAGVISTPSVDYFEQPTIACDYLYHLCRLGDDSLGFDPTATRLRPDDVDFLRINVAALPDAKDVDHSERDLSGGDVREPFTFAYIRSLFRTSLDCDWPRHRLVVQDGGQKHDYLVGKPTFHASGTMGRGTRGYVAYECSSRRFVWLKDAWRASYKITDREGDILAKLNAAKVTNVPTLICHGDVNNQTTITADWWERQSSLLSLIHASRAGSSRLSSDTSSDPVSLSGRKRKRADDAVVDTLTMQADGSMPHAIPETTGPLRQHTHYRVVVAEVCLPLKIFQYGRQLVSIVLDCVRGMSFSHASWLPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT81</accession>
    <name>A0A4Q9PT81_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 92 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_538535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT81"/>
    <dbReference type="STRING" id="114155.A0A4Q9PT81"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020803393" evidence="1">
        <location>
            <begin position="25"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="59"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="321"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="831" mass="90974" checksum="D24B46CC5BB72EB3" modified="2019-07-31" version="1">MLSFAVSVALGALGCALALSPVLGIQTSVAFSTSGTTLASAVQPAASSSLFIPDAASRVNVFVGTTNGGHVFPGALIPQGMVKAGMDTDSPGNHAGYDANPIFNVTGFSQLHDDGTGGAVPLSNFKLFPLASCGKGNTFEECQTSIDGRKVLRNVLDDGSPDDAGEPGYFASNLSTGIRVELTSTRRTALHRYTFPAKTEFPRIVVDITNDGQQSSTDPTMELDETTGRVKGGARFAASFGPGRYQAFACVDFKGDGYDLGAPIEFGAWLGNFPVKNTWTINQLYTSFVDELGALFTFNPKPEGVTTILARIGVSLISADQACANAEQEIPEFDFEGTRAASRAQWSELLGRIQIDPKGVDPEIVDLFYSSLYRTHLSPADYTDENPLWDSPEPYYDSFYCNWDTYRTLYPLMALHDPATFARIVRGMINIQQHEGWLPECRGATAKHYIQGGSNGDPILAEFYVKFQEQADALSVPADALYNALVADAEQESGNWDLQGRQASTWKILNYIPQDLFERNGSNSKQVSRTLEYSFDDFTISQVAKALGKTADGSKYAQRSENYQNVWNANLTFPGRSDIVGFMQPRFVNGTFNFTDPRHCSIHDPLQATCFLNAQNHDGFYEGSPITYSQYVPHDTAKLIELQGGNQKFIDRLNFIFEEGYFDSTDEPSQQIPFMYHYANRPGLSTQRSRQVIAQFFNTSTNGLPGNDDSGAMGSYVAFYLAGLYPLPATRQFLLSSPYFPEISFRNPVLNTTTTIRSINFKGNPNDGTGGQVFVKSVKIDGKPWHSNCFIEWDTFTNGSLIELQLTNEINVSCGNDKSALPPSLSTGGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTG4</accession>
    <name>A0A4Q9PTG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_537130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTG4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8931" checksum="D0EBE34BFAB202FF" modified="2019-07-31" version="1">MSQKVRVTTKMLLIISSRRPSRLRRHEGLVILIAGGANWVASISRMKKRSLAAIGERRVLDSFVGLKTFEYKAAYRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTR1</accession>
    <name>A0A4Q9PTR1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_928400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTR1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33372" checksum="C4EA69858E749581" modified="2019-07-31" version="1">MSPHTTPVTDLGLPIELWIQVLRSASRGTQAKMMLVNRPLSEIAESLLYHSVTLTWNIDVPKFSQSIASCIRRASLVIDIHILQIKPLGDNRVPALLPYLIGTLQNLRTMTLKMTVARMASCDDILHIRLPHLRSFTCNMNINSDEVFFNFLTAHEELVELDLGFTYPPNLPGVEDRLDKKPFSSLHTIACSSRWLNSRLPVLHNLTHLYRTGYIATEVAHIATLLDPQLISLRLRGRRILTGWDRTEPWSLHEVATKLPKLRYLQIDAPHVCSLLVPLLRSEHKYSGLVQATN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU25</accession>
    <name>A0A4Q9PU25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_511271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU25"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="230"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="661" mass="74213" checksum="4AA4CA1BB01C1D3A" modified="2019-07-31" version="1">MWLLNTKTAELKFFHTPSDLRYAILSHCWRDHEQTFQELQTLRAQHFSPDGTPRSRVSAKIRQCCIYAERAGFEWVWVDTCCIDKTSSAELSEAINSMYAWYAHAAVCYAFLDDTRDNENPSTPRSSFRKSRWWTRGWTLQELIAPKVVIFLSKSWRFIGTKHSLASLVEEISGIDRGVLVHERALDDISVARRMSWAARRHTTREEDRAYSLMGIFGVNLPTIYGEGPRAFLRLQEEILKHIPDQSIFAWGAILDDYPFACKGFSTDSEDQHWPSSYTGVSPTDMQTLLAPSPVEFAAAGRIRPIHVADLYRRLGLQQDEIAGPHYHITSYGIRIPLPFIPYEPNSGLSLTAPANVSIAVLSCEHEDGSLVLLFLRRKQNTLGEYYVGDFVDVGDSAEIFTRAYFRVAFLSKSAPNLSSPTIVRDVYIHNRVHPAMRIHLPHRTLADTEHIERINYSFFFPEWVLSRLQTVGGFVPQDKRAGDDGLTLDMPVLPGLDVSAVFHLTRVTQAVFAQPDNERGGFVVTFGIGCICQLTHKRRGFDAFWVEVAHAPLSANQRQLRQKWSAALGPSGGCARRHLKHAPMDFADARGTVRLTVTPWGGSPAGAAARDFSYVVDVELLEPDEGGAAGPASPVEQPSSTRATLRRAVELLWSLRLGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU54</accession>
    <name>A0A4Q9PU54_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_769503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU54"/>
    <dbReference type="OMA" id="PRDYNTH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16458" checksum="A46C57F87A2C0E71" modified="2019-07-31" version="1" fragment="single">MTPQKLQKEFAETYTQAEKEEALSKTAEIVRKYSDEMVKRWNEEIDTLLVYAGLFSAILTAFNVQSYLLLQPPATPDPTLAVLQQISLQLNSFSVNPPFVNSTQHAIIPSIPPTPEAESWAVALNTLWFSALICSLASASCGILIKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV89</accession>
    <name>A0A4Q9PV89_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_480297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV89"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="189" mass="20834" checksum="5353882A2ACA6D1E" modified="2019-07-31" version="1">MTSDPTKEISMQPRRSWEGLFHDDEDVPVSTPTSSLDNASIDDQGGISLSWQRGEGSLSSATEHRHNPTIDAPDAAIVREVLRGKRTLVDVDEDPNTGDMVAQHGWIAYHAHEKWPGENIPYKKPNGPRGAPRTTTRDGNYEDDTSFAELGLKRALMKKPSLMHNEGERVAHAEGMRGEEQGCSCCGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW34</accession>
    <name>A0A4Q9PW34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_445200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW34"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15628" checksum="7D14E363102695BA" modified="2019-07-31" version="1">MSACIRPGTFCARHVMQIVSSPARLATPHETSRAHGAISMPSDILRSFELCCRSVTSRELRRRPGSGGRLVSSMTGSLARWSSMCLLLLSYVPMKPCARGRPTCGRTVRQIRHGGRTWCFSAALCALRGCQRNSLSQYAGRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWA4</accession>
    <name>A0A4Q9PWA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_926546</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWA4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWA4"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU58790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="807" mass="87471" checksum="615186E4E275DBF5" modified="2019-07-31" version="1">MSGAEHVYASAATNRYSQAADVVGHSLVAFGSGKLVGLWDAADSLDRGVYATLPGHDGLVTCVRWIHDEFLVSGDDKGVMRFWSDEGSQWKSFSAHQAHKTGIASLSVLEKIAVTGASDATVKVWKIPDNENDKPLEIQSINLKRGYPISLALSYLPGTTSMILAIGSTDRNVYLWTRSEDNFASTAALPGHEDWVKCLAFKPPGSGAGPLVLSSGSQDATVRLWNIEPFSRTALGASGSTSGKTDDLLDAFEASLVNLEDTEDSGRSISLKRHILTVKSAAGNSQLFSVTFDALLIGHEAGVTSLSWRPQQSDSSVPTLLSTSTDSSLILWSPSTVLTSSNDGTTLWINRQRFGDVGGQRLGGFVGGLWAVNGRDTMAWGWNGGWRRWRCQSPLQDTAENHLEEWTEVGAITGHRAPIRSIAWSPQGEYLISSSLDQTTRIHGAIPAHSQTIKTAVWHEIARPQVHGYDLIAAAFLDPLRFVSIADEKVARVFEAPREFVEIVNNLGIAQLDSGEARPRAAAVPPLGLSNKALTDASAVAEVSAAFDSSRTHRRPFEGELAAVTLWPEIEKVFGHGYESIALAVSNDKQYIATACKATTAEHAVVRVYDTRTWQLFGQPLAGHSLTVTQIAFSPDDKLVLSVSRDRTWRLFEKSEDGYVPVAADKSHSRIIWDCAWAPDGDTFVTASRDKTVKVWKRPDESGQKWEAASTIQAGAAATAVAFAPESSQSKSMKLAIGLESGEILIHTSTRDTPTQWTKALTIGTRLAHIDHIHRLAWRPGKRETHQLASCGEDGTLKLLTVHIAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWJ2</accession>
    <name>A0A4Q9PWJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_434084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWJ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="160" mass="18208" checksum="108256896CC23CE6" modified="2019-07-31" version="1">MLEQRSQEYEGSSIDAPSPSFGKSLTCTRDIAPPLITLPLYPPASTYGRLTTTIGREQISDGNLTVNHCLEVRLMTVLDNLVIPWSAPQRVDVRRRWKRARHTMISRKRQRRKRIGRAVGGQGGRRALPAREAHPCGEEAQLSKRRRLRRRLSVRCQGIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWW4</accession>
    <name>A0A4Q9PWW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_948312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWW4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="295" mass="32921" checksum="2505BA1F37A53D8A" modified="2019-07-31" version="1">MAAIANTFAMDPFTQEVLMRLQPKRYVGLVVWSGMQPEYAEGAQEGDPPLRHLEVLAPLFVASGPPPIPEAKDMYLPIDPSPPSRTQEKPQSHSVVVTDEDSVMTVDGVFDMEDEFPEQDVQESDQGQASDCHDAMMDEDDGQSAHNPEESSQALDEFGPLSAIRHPSLLPLRGRVQWLTFGTRLHITTFHESSLSFYVDDDEDQPPYEWRRFEALVTDNLAALFDRSSSPPDADGTSAGSGDESDALVQKLRVPDISLPAIVWRDIRGEHEDDPTEFVRELDKIHDILGELRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXX2</accession>
    <name>A0A4Q9PXX2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_384361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXX2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="81" mass="8915" checksum="0B4BB14861C7C302" modified="2019-07-31" version="1">MESLCRPNRGAQLWWPLATGRVERRLMRTDGLAETSPSTRLRKLCSDADTGPPAQSPSTWVSIDADGSRLQHSRTSGFSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY35</accession>
    <name>A0A4Q9PY35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_409108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY35"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10932" checksum="AF0228395481035A" modified="2019-07-31" version="1">MLQYVYVTCACRCCLHSRRLFSYLRNRHAQRVLEVGGTRVSGGVLVAVGATGSDMPALSARGQGGRMLSTTTQERLGFTPPSSLEWAETRCCTCSMLQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYY5</accession>
    <name>A0A4Q9PYY5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fatty acid desaturase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_816452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYY5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="86"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="414" mass="48287" checksum="E8DCAC014606A3E9" modified="2019-07-31" version="1">MSRQYLEDDLPEFTPMSWRLQEIREAIPSRLFVRDTRRGLAWLALDLLMAAVCWKLAVHIDPTFRSRAAAQLLTPAGAIVVRWSCWIVYWWFQGLIFTGIWVIGHECGHGAFSANRYVCDLIGFIVHTALWTPYFSWKISHHRHHCNHASMERDEVYVPKTRSDLGIPEESNDGKIDYDEYFGDTPVYTLYMLVRQQLLAFPAYLLTNVSGQKNYPRWTNHFDPNSILFTKEQRHAVIISNLGILGMIALVRLACIAWGAASVMKFYGIPWLCVTHWFIMITYLHHTDPELPHYRQPEWNFQRGAAATVDRDFLGWMGRFFLHDVAHYHVVHHFFPKMPFYHGEEATQYLRSFIGEHYHRSDKPVFKALWDNYNDCQFVEDTGDVLFYRNKKGQAVLRPAATHGKVKAETGSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ24</accession>
    <name>A0A4Q9PZ24_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CxC6 like cysteine cluster associated with KDZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_359210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ24"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZ24"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041539">
        <property type="entry name" value="CxC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040898">
        <property type="entry name" value="CxC6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18718">
        <property type="entry name" value="CxC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18721">
        <property type="entry name" value="CxC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxC5 like cysteine cluster associated with KDZ" evidence="2">
        <location>
            <begin position="2"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="CxC6 like cysteine cluster associated with KDZ" evidence="3">
        <location>
            <begin position="173"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52966" checksum="A37CAC910206EC6A" modified="2019-07-31" version="1">MSHSLKCDHCNSRYYSNYFTDAVTQTRTYYRGIPAAILLTPHVIIETSLCYRFTWSTVCAWVSFTNNARIYNLEHSDARERFPEAFRSIQPDLSPSLLSDLFFLFALLRDRDEEGLCLVHSSHGEQSDRLDALLQDRTLRWAGPGRENWDHVCNKCRLQKDVSGSRYAIRAVVVDGITIGRPCCNVHDCQNPLPTQRSRFCETHRDLKMICAVVGCNQHASPNKQTCPEPSHRALEDPNGRSALFILRRRLERLQTSSLEDEGTGVSEELTEYDENGECPSKSEEGNTKPRARFGRRRTHNEQLVVATCGVILGRATMFGSEGIDGVMQFLKNMFPLLLPQVIFFDNACSLKKHVIALKEKHFDNCIMPVDAFHAKTKHKESDNFCNQHCNAAQWPELFNGDKWIFNSSAAEMTNAWLGGFQAMVREMRAARYDFFLDEVIKWRNRLTIEELSRVGADPKLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZG8</accession>
    <name>A0A4Q9PZG8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_923861</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="17778" checksum="CE9DD8A490D23B3A" modified="2019-07-31" version="1">MRHDVGVLPAGARPALLPDVRVLCRVPRSSGRTRPARHARLDLPHPISFALRCHAPCPSRLVSPDSARPRTPHPAAGGGSASMLTCFTIRRRTSGAQNHPTLLSRVHYNRGAHRMRSVLPVPPDVLIFSAASSILLSTGLPSKLCTRTTVARRLSSSHSSVSSVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZM4</accession>
    <name>A0A4Q9PZM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_848352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZM4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10124" checksum="C3E840965B065E9E" modified="2019-07-31" version="1">MKPHRPPQGEWIKSNPCPDLLPRTASSGTSRHEEASDLMNSERTSPNSRWLLHAYLFWTSLGDGTSDESGEKEPNLGTQHFETSKSLIGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1N5</accession>
    <name>A0A4Q9Q1N5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase M50B-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_946983</name>
        <name evidence="2" type="ORF">BD311DRAFT_776666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143404">
        <property type="protein sequence ID" value="TBU30661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1N5"/>
    <dbReference type="OMA" id="WYCLFVG"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="248" mass="27260" checksum="184146D70DAD63AF" modified="2019-07-31" version="1">MVVYAVVIFAAWVMPGARMIITPLKLFTIGWHELCHITLAVLTGGSVMKVCIDPDAGGATIVSGGHPPTILAAGYVGSTILGGLFIMAGFDTLVSKIMSFVIGIGLVAPLALVRNKLTILLTVIWEGLLIGFWFIDHACVTFSNFVAHNSRRDALFRQALRWYCLFIGVMNALYVVWDIADDKYFRKANDSDATQWSIMYPKTRAHVWAIFWIAFEVAVIIGFVLLGIAAFKRTPDEMAAEAAQFLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q355</accession>
    <name>A0A4Q9Q355_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_195490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q355"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19463" checksum="855A7F762C2DBAAB" modified="2019-07-31" version="1">MDGEGERGDAPHRPLPLRDEQMRRGQSSRPVTGSRCAVPLHHPHRGRMDGEGHDATPHAHTCEGPFSKPISRRICPACPSQTRARQRRCASIGPSLALPPPQHDMMVHRWLGDPDDAPHRSVEHIISYGTPALAVPLLPSRSKRPPCAYQPRRAANGRFVRGTPGCGKSDIHDDICI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q356</accession>
    <name>A0A4Q9Q356_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_920537</name>
        <name evidence="2" type="ORF">BD311DRAFT_711692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q356"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q356"/>
    <dbReference type="OrthoDB" id="2688364at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="513" mass="57569" checksum="072C577621F5088C" modified="2019-07-31" version="1">MSTATKRPSISSLPDDVLLLIISFIDIRDILSLRKTSKRLFTMSKLRWVWYDAMKRHVIQRGLPIPAAVATDLKALTAEHLEARAVHAAHFHDNWNSAHPVARKAVEFCAVNYMDDELPDEHRAAVTHVSFLPGRNGQYLITAVGRVLTCWEVPLGESEAYRVAEWVSARRIEQVIVNDDPKAEVVVAYVSAHPITQGAVECRAFTFDKFHGRFNCRMELRAHRQVVMSLHVLHSDYLIFGDPMHVCYLSAPTIVKPLGKQSLAELPENLVLAVKPVNRYLLIVRQRTFEITLAPSWKGLRIPQASLVAASMCIEMDIPASSSVIVFRDNSLVVDEDPPDWPKDPVTVLSRYSDDVFDTVHQYDLLPNPKAKNEASEDSSKGYNGMMDRLPCVFPSQCTRVLNVAPSSCDLRIGPSGKGFWTETRNITLRHARTPARCLVGFTVNPGPYDTEKKADVQPAHLEVCKDVLYSRRCNIHEILWKKYMIASTALEDTVGRIAIGDVTGRVEVLDLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3S4</accession>
    <name>A0A4Q9Q3S4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_872903</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q3S4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF37">
        <property type="entry name" value="ENDORIBONUCLEASE DICER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="29"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="398"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="11">
        <location>
            <begin position="594"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="1020"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="8">
        <location>
            <begin position="1210"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1124"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1526" mass="172994" checksum="B4CB7FB03B03AD01" modified="2019-07-31" version="1">MATTEIRDPVDVEPPRSSIVHTRAYQQELLDESKRRNIVIALDTGSGKTHIAVLRMKYEAERESRKVSWFIAPTVALVEQQSEVIKTAIPVSVGYVSGASEPNQWKDAGLWRGIIAKHRIMVTTPQVLLDALHHGYVDMGSDISLLVFDEAHHAIGKHPYNMIMKKHYFGLPPRSPLGTSTSRVRPMVLGLTASPTYGANVDVAFRDLEKNLDSTIRSSRNNRHELAQYVHRPEFKHVIYASPIHVQDGIPSVNYKALEVVIAELDIEQDPSVIALRARLAKLQPGDDRRRVDQQLSKALDKKDTFTHKGLRDFARTAADICIDLGTWAADWYIARVIERAKQAANPYNNIMSAWQEKEKRYLLGILNRVSVMEPSEDIEQIVANLTPKVRTLVDSLLVEEALFRSMDEEYSGIIFVTRRDTVLVLAELLRRIPETSHLFRIGCLLGSSSSFKRHSFLDITRSMLDESQSDVLRDFKIGDKNLIVSTSVAEEGIDIQACGSVVRFDIPPNVVSWAQSRGRARRKRSSFVIMFDQAEPREVVRKWEETERQMMAAYNDPRRDAAASVEEDDFDDLDGYCEFEVASTGALLTIHTAVPHLNHFCAVIPTGGHEHLVPIYELDPPDYAEGWHALPEHARFTERYTGPWGATVTLPRALPPHLRKFSVDRIHRTKRRAQQRVAFEAYVALYQAGLLNNHLLPHTSGIEPEKEDEVKAMLAEVAKRESTAQVSIQIDPWATAEGTPSWFAHELVVEGLPSLRMFTRRPLPTFVQKDFPTLYVPGRKELSMTIGGAAGSPASDEEVHLAQRWTYRLFWRLYGPRMERGREDFAYLFLPIGSWPDAEEWDERRRWMDDRFMGGLALQGETPFAANAAAFGARFSHPTNLPLVRGVSKYNKPLRLLRWQYDPLTTEEEEKFREEYSAYPDLEITYPLLVVRSLPKRRNFLIPFPEEDTDHEIPSQSGDAPFLLHPQYTLVELASQTEVQYTLLLPSILRWLAMALTVHSLRTSLFKQNPVSTVALRHLVTAITAPAAQERFHYQRLETLGDTVLKFITSNLLYADFPLWHEGYLSRKKDHAVANVNLARWAVKKGLYRWIIRDRFIPRKWKPHYSSAAGAFDEILDDRSREGTPTASDAAAQNGNSKESRKGKAEDLSTKMLADVVESLIGAAYEDGGFDRAIDCVTAFNLGLSWKKLPEYIGAMHAVDDIDDIPKQLALVEQMINYRFARRTFLVQALTHASYQGDFATMSLERLEFLGDAALDMIVVDYLYHAEGKDYSPGYMHIKKMAVVNSHILAYTCLKTAVTVESTMPTWSPEHGLEAVDDSQQVYLWQCLLHSSHRVLEDQNLTFLRYQKHGAEIADALENDAVYPWAGLTSLQAPKFISDMVESILGAVYVDSFGDLGKVRQVMETLGLMRVLERVVHDDVDALHPVSRLEIWAAQHKPRKEVEYKLTKEKGDVTCAVYIDEKELLQVTAPYRSKVSEDEVRFKAAEKALAQVRAENMDIDKDVFDGDDEEVEAMVADTEAHADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4G5</accession>
    <name>A0A4Q9Q4G5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918985</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4G5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15486" checksum="EC212D15848082AF" modified="2019-07-31" version="1">MSILLCHALVKIQNDRDLPLILPFPQDGTRTLGDMVAFAACILEFPVAYVPSGDGSDPFLAGIPLDVYECVLVQPVLGLPKHTMLKFSCPQTITAEVSQLRPDVLGERLRARFAERLERAGFRGTLLLRHTVETMDRVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q518</accession>
    <name>A0A4Q9Q518_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_986211</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q518"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14273" checksum="16AA0DA463A1FFF7" modified="2019-07-31" version="1" fragment="single">RQVCVSGYVTARNVVHASLPHALLAWSADGVGWGTLGARLFDLDVEKISLLTNADGSTFSHLYALPYATTSRCLARTTTLIPCIRAEGRITRFAVMSDVSRRSSSALLGFIYSYRYLPCCHLASHVFFDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5B1</accession>
    <name>A0A4Q9Q5B1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5B1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="93" mass="10200" checksum="1343008170BD0234" modified="2019-07-31" version="1">MCSLLWLRSNLSSGFRFSLRLIVQSYSLTRPAIARPIRPDPLSGVGDALRLPNAIFYCAFPKRSPTSLSLTLAPRLSHYAHAVLASRTEGSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5I1</accession>
    <name>A0A4Q9Q5I1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_56665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5I1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5I1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="36897" checksum="F1F2479EA2CDCD66" modified="2019-07-31" version="1">MPKELKEPLYCCGELHKSGTYHRRTVHQQYTKISFKSHPEASFLLKRNSKTHLFHCPECDKSWAMATPIRNHIVTRCEGYVKYRSPQASSAVKTRAAARGQQAQEVSTGMQAVKEEGVEYSVEETQEHEHAAETAPLVKSPSVRSNVYVNSNDSGGDNLAITPEPLSPAAPNSSSPSPERVSVLRPAIWSPVSASPSVRASVSPSLLSVPPPLTQSVSTRSSTSSARTWPDDYPPGVPHMRFKTENDHTLLPEAASQSGSCSLSAARIFLDGLRRPLGNAAPQLHALGIVTTADLDLICTMPDAWDEVGDFLRGSGVTIIEWLMVKEAFKARAKVTASAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5Z4</accession>
    <name>A0A4Q9Q5Z4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_918054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5Z4"/>
    <dbReference type="OMA" id="EEKCRYA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05288">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000121">
        <property type="entry name" value="Prostaglandin reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041694">
        <property type="entry name" value="ADH_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045010">
        <property type="entry name" value="MDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205:SF42">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, ZINC-CONTAINING (AFU_ORTHOLOGUE AFUA_7G04530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43205">
        <property type="entry name" value="PROSTAGLANDIN REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16884">
        <property type="entry name" value="ADH_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="342" mass="37404" checksum="4BD58D1291CBD6A1" modified="2019-07-31" version="1">MAPSTYTRVTLQERPPEEITPTTFKQETVPFDLKPGRGQILVKILYLSLDPALRGFIKDQRSYMRPVQIGEVMRGHAFGEVIEAGPGSKYKVGDIVEGGFGWTEYGVFDDKVAEKIEHQPGLDILDFLGPLGTTGLTAYFGLLDVGKIKAGETLVVSGAAGATGSIVCQIGKKKGAKVVAIAGSVEKCQWLEKDLGVDKALNYKSPSFYDDFKKEVGYLDVFFDNVGGDILNFALTRLNQKARIVLCGAISDYNKAKPKGLSSYLNLISQRARIEGFIILDYAPRYAEARKEIAEWLKEGSLKRRFHVVQGLQNAAQAMNLLFTGGNTGKLVVQVSQTAAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7Q0</accession>
    <name>A0A4Q9Q7Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amp dependent CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_841694</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7Q0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7Q0"/>
    <dbReference type="OMA" id="FHTADLY"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="50"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="471"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="587" mass="64777" checksum="2F5585D44D872800" modified="2019-07-31" version="1">MTTQNIPTIYGVGGPVARIPDDVTIPQFFFDQHHELNGEALHLRQPTYFIDDATGRHVTGDEVRARVLGLANALHIRWNIGDGDVVCIYGPNHVDYSTVIWATHRVGGIVTGANPAYTAEELVYQIQTAKATVLFVHPDALPVGLEAARATGIRDDRIVVFDAVPGDNHLTVTDLVKEGLLQPKRYVEPRLKPGEGRTKIALLCFSSGTTGRAKAVMIPHYAVIANCIQMKQYANTRDAPYPNEKKLYRSGDVAIAVLPFYHIYGVVVNLHYYLFCGMTLVLVQKFNFENMLKSVQRYKIGHMTLVPPMVVLLCKHPAVKNYDLSSVKLLTCGAAPLSAELTHQVAKLLPHAHIGQGYGMTETCTTVSFPQLDMRIGTPGSAGRLIPGTAVRILKADGSWGGVGETGQLVVSAPSVTIGYLNNEEATRETFKDGWVYTGDEGYVNEKKELFIIDRIKELIKVRGFQVAPAELEGHLLDHPDVADVCVVAAPDDYSGELPFAFVALHERVRAQVAADPREAERVRQSILKHVADHKTQYKWLAGVEFIDVVPKNPSGKLLRRVLRDRLKEGLQAGRIKLVQPKERAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q882</accession>
    <name>A0A4Q9Q882_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_903354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q882"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="363" mass="39448" checksum="6389A6EB59C87480" modified="2019-07-31" version="1">MAVRLTCASFPSIRDLYGLREIRRRIASISGRGEVTLSQTTRSFGGTPFTPVPGFVRSSIGEVLRALDIFQRPDFSFNTICKNLGSPRLEDTSLFALNRQRGQASNDHLRRIEPARCKGIGFASSKVSAFNCSSDFYNTVKLKTSETRPQNVARVSGGISFSTSLNEIRAVLLTQSDPILGSTFNDIHRLRDLSYHEEIGPRSIASRSLLPEIGQSPPDDEVVSDIGVKPGIESSLSIAQERSDLLSGSQSLTLASDSQKSSETSSHALRRLVVEAVDSARLLRASVSSRMTSILTISSHVAAFSAIETSFGVKRSSGQVSDENPRFPVLRPSAIAFTPQRVSLMASVSEPMPLGIRPTDWSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q894</accession>
    <name>A0A4Q9Q894_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q894"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="139" mass="15357" checksum="C7F1C761619DDE2D" modified="2019-07-31" version="1">MNMSWGFRSSGSGASRDGFSIAELMLPDHLLLRATSTADPEGKCMLGNWPAYSFGIEMLLRIRGLEGHLDEKKGRSSRVNADQWQAEEDLCKLVIGFNVKDFAEVFGSSLLPIRETTAAAMWSELAGRFLAGEINCQHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8E3</accession>
    <name>A0A4Q9Q8E3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_809705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8E3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8193" checksum="B1A0B1F517931C20" modified="2019-07-31" version="1">MGAMRGGGEGQKVLCDVGNAEDEGRSADDGSTRQTEPQGGEPALPSRAAATATDIYPPQPFSAPVLLVQLGLDVHLSRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9U6</accession>
    <name>A0A4Q9Q9U6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_869002</name>
        <name evidence="12" type="ORF">BD311DRAFT_682979</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9U6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9U6"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03700">
        <property type="entry name" value="EF2_snRNP_like_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000003">
        <property type="entry name" value="Elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="17"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU34787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU63821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="842" mass="93435" checksum="2DB5B0248EDB0BD3" modified="2019-07-31" version="1">MVNFTVDQIRALMDKPTNIRNMSVIAHVDHGKSTLTDSLVSKAGIIASAKAGDMRFTDTREDEKERGITIKSTGISMYFEVDKEEVSAIKQQTDGTEFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCIEGVCVQTETVLRQALTERIKPVVVINKVDRALLELQVSKEDLFQSFSRTIESVNVIISTYNDAALGDVQVYPEKGTVAFGSGLHGWGFTLRQFASRYAKKFGVDKEKMMLKLWGDNYFNPATKKWTTKSTDADGKPLERAFNTFVLDPIFRIFDAVMNFRKDDVTKICEKLEIKLAQDERELEGKALLKVVMRKFLPAGDSLLEMIVINLPSPKTAQRYRVETLYEGPMDDESAIGIRDCDPNGPLVCYISKMVPTSDKGRFYAFGRVFSGTVRAGPKIRIQGPNYVPGKKDDLFVKSIQRTVLMMGRYVEPIEDCPAGNIIGLVGIDQFLLKSGTLTTSETAHNMKVMKFSVSPVVQVAVEVKNAADLPKLVEGLKRLSKSDPCVQTSISESGEHIVAGAGELHLEICLKDLQEDHAGVPLKISDPVVGYRETVRAESSIVALSKSQNKHNRLYAKAQPIDEELTQAIESGKISARDDYKVRARILADEFGWDVTDARKIWCFGPDTTGPNVLVDITKGVQYLNEIKDSCVAAFQWATKEGVLCEENMRGVRVNILDVTLHTDAIHRGGGQIIPTCRRVTYAACLLAEPTLQEPIYLVEIQCPENAIGGIYSVLNKRRGQVFSEEQRVGTPMFTVKAYLPVNESFGFNGELRSQTAGQAFPQCVMDHWEVMNGSPLEKGSKAEELVKNIRTRKGLKPDIPPLDTYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9Z6</accession>
    <name>A0A4Q9Q9Z6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RCC1/BLIP-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_869333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9Z6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9Z6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="109"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="110"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="173"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="240"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="299"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="356"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="415"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="479"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="536" mass="58032" checksum="EF63369F7A9FCA25" modified="2019-07-31" version="1">MPPTRTTRSTETRSTRSSTRKRAGSPPPAPAAKRRAAARPKAAPKSKPSQKEKEDEAPKPKRTSRPRRAPVRKTDRNAAYTSRPLNARQRDLPLLNPLPAPPSRERPCWQLFGWGPDNKDGPMGTGDEFAAEKPRRSKVVEKLIEDGEFGLNGAGLVAVAAGGFFSLVVDEIGQVWSFGNNEVGQLGRTTVKSADGVEVDSETSVPLHTPVRIRRLSDEFFRAVRIAAGSCIAAALSDRGELRVWGAYYFSQNSGGQKFMFSPHVDTQPFPVHIPELVGERFSDVVAGANHLVLLTVDGDVYTIGKGSEGQLGHKVPKATPTQGTVPYKVLRNTHGHRAVAIGASNDTSFFVDQQGDVWVWGLNGYGQTGTGSKQNVLWYPHQAKRVRRKDLGGKATVVQIVGGERHTLFLASDGRVFACGNAEDGQFQLPAGAEGDIAKEVARVSEPVPVQFPHDVKEDPVVQIAASNRMNAAITRDGVLYTWGLNSGGMLGTEVESPDDIIKTPKVIVRREGSWLAKAVSCGGQHCLALLRKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAH4</accession>
    <name>A0A4Q9QAH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_280660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAH4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7579" checksum="0833CAFE95D510B2" modified="2019-07-31" version="1">MGRRPAWMSLFGSWNHMGYVRLAADASRKPPHRTSGSSISVKVCPATEGLDLARLCPRHGTGCPRIRCGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB16</accession>
    <name>A0A4Q9QB16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB16"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="23534" checksum="7197DF5E7C8D1D9B" modified="2019-07-31" version="1">MLPDGHSTRLRTPRTAILTSRWKNRSFANACKERYADFIYHDTRHHMNRSSRRRHLLPVLEVLRTNIASNASSPDPVIRAGRGPSPGRSCANRAVSCHWVFLHLPILPPRRHVVRLFYQIEQTQSRPSPCPGLSSHIPCAPSQWRCSSSLKPVPSILVAVHRHFKCNCHEGNFQDTVACLYAFSPHSARSLLLKGPERGLCAHDRNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC96</accession>
    <name>A0A4Q9QC96_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_913635</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC96"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC96"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000295">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="11">
        <location>
            <begin position="45"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="151"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU64910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="39919" checksum="EF64162AF1F58134" modified="2019-07-31" version="1">MPGRVKKRSPLKAPDRPFIALGLEGSANKIGAGIIKHDPDGSTHVLSNVRHTYITPPGEGFQPRHTALHHREWALTVINDALKKAAVSMHHIDCICFTKGPGMGAPLVSVALVARTLSLLYDKPLVGVNHCVGHIEMGRQVTGAHNPVVLYVSGGNTQVIAYSQQCYRIFGETLDIAVGNCLDRFARVINLSNDPSPGYNIEQEAKKGKRLLPLPYATKGMDISLSGILTSIEAYTTDKRFRPNGPTAEDGDDVITPQDLCFSLQETVFAMLVEITERAMAHIGSKEVLVVGGVGCNERLQEMMGVMASERGGHVFAMDERFCIDNGIMIAQAGLLSFRMGFETPLAKSTCTQRFRTDQVHVTWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD92</accession>
    <name>A0A4Q9QD92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_2111</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="26411" checksum="206F134000BE2800" modified="2019-07-31" version="1">MAPVQCKRCSWAIYSSKAVFTRFHGGLYGPGHTGAFVCLQCMDTFKKLKQRKIHMSSTRHKDPEDFQAMMAAAAAAADISPSTMPSINVVSRKCLHSHKDIPSGQTHAHCGLAEELASTARCSPLDTEDDHATNISQNISTDPHCEFCTIQLTPLQTLEEHYWESSSHLKCRPCVLGFGNLKAWAEHRADCPVSPFQRTSSKEAVGKQPAASLQQCRLSLGPSQPESTSVSRYRDYTGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE90</accession>
    <name>A0A4Q9QE90_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_912615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE90"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020999242" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU66035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8571" checksum="6195DE3F0D724774" modified="2019-07-31" version="1">MLTMIVFHILIPISLFGQYRLGHIPTGLAAIVHMEDKTTGGTASRTRAHHHFIGSMMFVSTHKSTGPPERGMALRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEP6</accession>
    <name>A0A4Q9QEP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911070</name>
        <name evidence="1" type="ORF">BD311DRAFT_792830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEP6"/>
    <dbReference type="OMA" id="TWNTANY"/>
    <dbReference type="OrthoDB" id="2747613at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU35444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20378" checksum="0A92B2610D3D11C4" modified="2019-07-31" version="1">MALVDHLWLAGQLHQLTFQPFGTYGISYDIYTRPTEDPVPGGWESPRVKTYRELIKRLRAAGFGHHQYSDHCHTEVAALEAYQVMIDLTHIRPNNKLSTTVKGLKLHYIHDMNLMDVSNEVKLGGHLAQRLVGPAPRNLVHRLVGNGHNLSAPLQPVPQGHPGVPPLYTTPSPAAMNVANYVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFK3</accession>
    <name>A0A4Q9QFK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec7-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_802945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QFK3"/>
    <dbReference type="OMA" id="CRDIRHH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000002">
        <property type="entry name" value="Cytohesin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="577"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU66001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1511" mass="166694" checksum="8E3AFAF6D0CC6EF3" modified="2019-07-31" version="1">MEPTSSTSTATVVSVSPKHILLSEILSVTSVMRKNSRWALSTPSYTLRDSTLASSLGLRVSKSSPNTHASGHGSTEQELMAGFQDLKRLVKDIEDIHSLPLSTLLSPFLAIIRSPLSTGPITSAALTALHNFFLCGLFYPTAFSLPSALSELSSALSSCKFEASDSSGDEVVLLKIMTVINDAMCGDAGRTLGDIEICEMLETVLTTSCQMRLSEVLRRSAEETLHQLVRAVFARLHELNPEAEEQKLDDTGDLESGEVKMSVSTSGPAPQAQEPDSSAEQDAPSQENGEVQVAEVSSSPHAQEQPPETPSQPHGLPSILELLRVLINILDPNDQAHTDSTRLTALRTLNVALEATGSRICAYPSLSALILDHGCKYLFQLARSDHPAVLQTSLRAIATMFETMRPKLKLQQELFLAFTIDRLTPLPPPKNLTLNQKALSANSRGSSPAPGTPLLAPPEDDSEKTPATPRILVPPARGDTRELLLETLCQISRHPSFMVDLYTNYDCDMNCENMFERLIEFCAKGIYPSQGLGGPDNQQHNAQYLCLDLILAFVGRMATRAEGASETWPRSFPPPEQLQLTKSKKKLILTGTAKFNTKPKTGLAFLEENKLIYADPNEPKPLSLAKFLKSSARIDKRLLGDFISKPDNIEVLKAFLSLMDFKGKSVAEALREMLETFRLPGEAQQISRITETFAEIYFAAEPDEIKSQDAVYVLAFSIIMLNTDQHSPQIRKRMTLEDYKRNLKGVNEGADFTPEFLSNIYESIRKREIVMPEEHTGQLGFEYAWKELLARTRQAGDFLTCNSAIFDADMFKAVWRLVVSAIAYAFITFEDDYIIEKAIAGFRQCATLARHFDMPDVFDYVVISLSQATSLLSESQPSQVPNYPVVDVDGQSTTVSSLSVKFGTNFKGQLAAVVLFNIVNGNANALREGWTQIFEMFQTLFLHSLLPPRMLQMEDFLSGSSVIPLRRSQPARAVPRSDGLLSALSSYLMTPYASSTDALVPDATDADIENTLCTIDCISTCRLDELYSQIMQLEPEALVAAIRALEALAHERTVAKLKLESDEAAAAAAAQGGQFALPYDPASVFLLETMVSIARQTPQYIEEVWPIVFEHLSALLSTPTQYSILLIERAVVALLRLCLILAERHTLRDQIYLSFDLLARLPPSVASAVAEQVVAGLTHILQQHREIVHSQTEWNVVFALLRSTISHPEASRQSFDILAALVGDGPQDSVTPDNFTGLVNALDEFATVAGIAVDAQQQGRRTQALTAANSPIVERGRKAVDMIADLKKCWARFAETSGLQRTLIWRQFSLPVLSSLARQSSNTSREIRHTALVHLQRILLGPHLPLDEGNHNQIEEVFNRVIFPLLDELLKQQVFMRDPMGMPETRLRASALLCKAFMQFEAREGQTADIRVLWIQVLDLLDRLMHVDRRDQLYEAVPESLKNVLLVMNATGLLVPPSTPEDDRGERQVALWAATHERVERFLPGFLDEIVPAPPPKSAGVPASSASAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QGN5</accession>
    <name>A0A4Q9QGN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_42755</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QGN5"/>
    <dbReference type="STRING" id="114155.A0A4Q9QGN5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09880">
        <property type="entry name" value="PIN_Smg5-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PIN" evidence="2">
        <location>
            <begin position="1088"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="936"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU66114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1259" mass="138492" checksum="E096DA757565B421" modified="2019-07-31" version="1">MQEPTHTKIATASRKGKEREGAQPDIADRIIALRRKQATAAPRERPDRPSQPSTSSPRLSTARPSSPRKSYAPPVSHPNIIVSEASPSHMEADADDFSRRLKISPHSPRAAHARPAANGSPGKLYNPNSDPIRRPVISAEPDAMSDAASSSHSPRAMPSRAQQPAQTSRGAPDSHRQLFDPRKHDAVLFSAQNRHHAPSAPPTNSPNAGRPTPTPKSSGDWVSASSTSSASYAQSTISSNFTLSSATDSSSASSALFDSSNPAGRRSEDSASSANAFSRKLKEVYRTISGLESKLLGNDRDRERGDNGERAAQRGVLIKGRPANSGAARDATDEEGESERWRKLVAGHQQLAESIREMLALTLAPTVPASLKNIPQKYNLIIRLWSHAFYHLLESLRHAARPPTSSLVALEYLQQFLNYAYVFYGGLIEERNFAQYRSAFLEALGDLSRYWMAVSALLEGTHTSSNTLTASAVATNNLLSSNTPRPSSPNPPATDLPSAAVSPTPARIDDSPQSSEAEMPLGADAVAGAAAAHMHNIPSVGQEAARLMELDSDKERWRQVAKDWFARGLAITPNSGKLQHHLGLLCRDKDGTDEELRGVYHFVKSMVAFHPFSTARESVLAMWSPAAQARRQAPDARLTELFVLLHGMLFTNIQLDDFKRVLERFQEKLEIGDGEQVEEREWIMMALINIGSLLEYGRQTAVLRRVSGIETRSVGGPSLSPTLPTGVTAGRIKVLMAKRLDGDTSRMDIDDEDGEGRQGASETPDGSTPTAQEPELPATLKHAMQLTFMMLSHTLRHPLRRPSEYATPTLNPYNTIMLTFLATVLREPSARSALERSIPWEELAAFLTTIPRRDVLREHQKASAESGLLLTSGCTPLPEDWCVRGMGWGGKKVFERGFWTQDADAAGEERNVEVEVLDRVEAPESAMEDVMEDDGDERRASDQSPEKRRWVRLARAGLRIARDVHGFKFAPASPAEGRPAWKVEGALADKVARWKEEERIEREAEAQRLRGTRWEDDSMEVDDDEDMRVDGESTEDEGDSEEIRKLKARRQYLQTLLETGQREPRRRPRGPRKADAGRPSLRLVPGYSVLVVDTNILLSSLAEFSALVESGRWTVVVPLPVIMELDSQANGNATPLGQAAAAALKYITASIRTHSASLKVQTSRGNYLTNLNVRTEQVDFSSNTWERNMDDLILRAALWQDEHWADRSSMLKADATKDTAGAAKVVLLSFDRLLRLKARSRQLDAASEQELAAILAHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K3U6</accession>
    <name>A0A4V2K3U6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_701071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K3U6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="488" mass="53732" checksum="EA72055893961370" modified="2019-07-31" version="1">MLSGSLCRSDYPLPSHFTSKVSGMWLATFALLATPTVVIGLANSALLDVRASDRAPSQLRLVENSGECETIPGVNQASGYADIDANNSMWFWFFEAREHPETAPLTLWLQGGPGGSGLVGLYQEHGPCRINNDSSTVSFNPFSWNNASNMIYIDQPIGTGFSNGDRQLNNSVAAAADVWQVLQILFADARFEEFQYNDFGVWTESYGGHYGPIFAQYFLDQNAAIANGSIRGVPINMKVLGIGDGLTDPLIQYESYLTYAQSNPYFPTTTNDTIQSATDFWNQQGGCKDMIHQCYDSLDPTTCSSAQNFCDALITHRLAGNQDEDYILADFSDTYPPDITQYANNTTRKQRIGAVGDFEEVNSEVLFEFQGEWMQNSRPMLEAVVDAGIRTVLYVGDADYLFNYFGVEAMLDQMQTKFSTEWAEQQFSNFTVHGESAGLFKNAGTLSYVRVFGAGHEVAAYRFGTLGSGEAAYQIFSQIVGNNPLSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5F0</accession>
    <name>A0A4V2K5F0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_414860</name>
        <name evidence="2" type="ORF">BD311DRAFT_792156</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143538">
        <property type="protein sequence ID" value="TBU22524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5F0"/>
    <dbReference type="OrthoDB" id="3357408at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU22524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37948" checksum="AE805E9750FF4F27" modified="2019-07-31" version="1">MALPDFPIDEAYLIGGWLASFFWGLYTLLFCMTLYSVHEKRRGGVNRFTTGSIVILYILATTHVSLVLVRLIQGFVLQRDTIGPVFYFVDIGEHVNVAKDYIYITILAIGDSVIVWRLYVVWGRNIRVAVFPMVMIVGELIAGYGAISMSLLPNPNPDTQANWGTGMYVMSMTTNIIVTGAVAVRIWYMTTQTRQVMGEYDSGRYNRAILLIVESGALIAASKVIEFTLFELSPTGGPDGLNAMYIVYEIIPQITGLAPTAIVYAVNNGFTQKDSLYSAKSTIAFNAPHHSTLSSSTQDNSSLSTTGFFANDHIQGAKHIKGDPAFELTAKVPRGAVPPSSLEFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7M9</accession>
    <name>A0A4V2K7M9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Maf/Ham1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_931131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7M9"/>
    <dbReference type="STRING" id="114155.A0A4V2K7M9"/>
    <dbReference type="OMA" id="VIGCDSV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF5">
        <property type="entry name" value="BIFUNCTIONAL DTTP_UTP PYROPHOSPHATASE_METHYLTRANSFERASE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28351" checksum="55299D5DFFDB050E" modified="2019-07-31" version="1">MMSFFSSKKVELPAHNCVLPHALRIPALEKLVGKRVVLASNSPRRKEILRTFGLEPEIVPSTFEETLPIGGFQDPHEYPVATATHKAVEVYERLVTEQPDDAPDLVIAADTVVLTYAPQGLHSQFAEELGGAPQDILEKPIDKEDNMRMLLDLNGGRCEVVTGVSVVFPVLEAPGYKIKSIDERTLVYFAQNDESLLRAYVENGEGRDRAGGFAVQGLGGMLVSKVDGDYQNVVGFPAASFFKFLDALIEEEVDFLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K889</accession>
    <name>A0A4V2K889_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_849811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K889"/>
    <dbReference type="STRING" id="114155.A0A4V2K889"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15398:SF4">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN 8 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="147"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="486" mass="54445" checksum="9C3C563A3C826C40" modified="2019-07-31" version="1">MASGVHTRRATSTPELDASNLNNVERLIFAQAVHEFGSDAWPEVAKLLSNHPLISQPKGAITPQSCSTLYQRLMEDAGLERSEADTGPRSEKHLRLAQRYYVARVTELRGLIASEEAKFKKLVTEIDEIRSGAWDDKILASMGAQLEKPGAQEEPTPEPQVSEPAQPSTSEDETKPAEEEESAKEAAMEEEQQQQLPAEQFTVIVVESSPAPEAEEKEEGSDNEAVNELIGNFSSDRPAVEAQDDIEPVVADAPEHRPAAEPQEDEMQVDEAPVKQEQEEDEPSDEQSVVEPAREIAQPEMEVEAGAEAEEEQPEADPEPAPTTRAEAKRKASDADTVMLDAQREKKRPREDSEPADEEDGAPKTRRRERTGGSDKRFQNMIGMLHSQISQHRYGNIFHNPIKKSEAPDYHDIVKRPMDLKTIKSRVKDGLISNSLEFQRDIFLMFANAMMYNRPGSEIYNMAEEMMVSSEREINAFRQTEGFHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8M4</accession>
    <name>A0A4V2K8M4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_922642</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8M4"/>
    <dbReference type="OMA" id="PAREVNN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="42369" checksum="2375419CCBC8B161" modified="2019-07-31" version="1">MGSAQSYLPVVGVIVAGAAAYGYAQLNKTPTPVSQAAPSPSAPVSSKKQKQKKKAAGTGAGAPTSDREKEKDAVPAEPSVVSFPPVIPGGFDAPASSEPQAERSKPKKKKKAKKAGTPVPADAQSESSATAPESSVAARTSKPKKEKGGASRPAAGLNDDGWTKVETKKKEKPAKAAGDAAAAAAEGGVQGGHRLEVSTSDFATSVTTGNSSPVTERTEDESQLADSFTSEHRRPLAERLLPKPRKTGVEDLLEEPDHPEVSRVMRVKPRPDERPAAGFSWADYEDVDSRGTADDADGEDDGGWGVVKTRTKQKTNKPASESGPAAQLKASESLTKKQRQHAAKREAEKAAKAEAERERLATLARHKRELEQTRMAEQAKASKKAVSGGMSATVDENGKLVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8N6</accession>
    <name>A0A4V2K8N6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_957514</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8N6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17541" checksum="3EB39A613C54C2FE" modified="2019-07-31" version="1">MSMDGIVNELFFTGPGDPRHKCVAIGYHNTVPIVYKFETVDLPQGTRTTVTFNEQTVVAYFDWAVCNHLGSILRGGDRTPMADFVSRGSIDTARQFQTVMNGREIFEWRRLGNRQPYAYELFSITPETTARIATYDPTPKDVPKLGRATVLEQMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K988</accession>
    <name>A0A4V2K988_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_662778</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K988"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19589" checksum="1CB6E56308F208E6" modified="2019-07-31" version="1">MGPYVKATASVHCQLELTLGIDARASRDPDGPASPATVLRISRRRSVYFAPTQRPQYSGVRGLTVETRRRTIDDVQQSYHCSRGARTDTICTRDPAQSPGSRPWCACAGKAERSGLGRRAMFTQLPQLKPVRKLQRRTGQRRALSLALRLRFLESGFHGATFALQCADVCYSRRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K989</accession>
    <name>A0A4V2K989_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_662146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K989"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="125" mass="13712" checksum="695F309689306650" modified="2019-07-31" version="1">MRVREVGCDAWSIRVLWLSTLDSGDIEEHGGGCCALWARFARNGCVRGSLRRRLAIILFVFLSPFGVRCGKTFRGAYGTPHQHSTSLDAPLPRGIAAHLLGRFATCASRQFNCGVCTRKTSSQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9U8</accession>
    <name>A0A4V2K9U8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1436</name>
        <name evidence="2" type="ORF">BD311DRAFT_860006</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9U8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU35448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="222" mass="24574" checksum="8CBC0B0648663AF2" modified="2019-07-31" version="1">MDVDQELARIQQAISELRASESQPQVLRSEPQPVHNDPVGNPPPARGLSRDEATELFIQQHVAEILAAMRQPSPRSRSVPRRDPDAILPDLVRPQHDPERRPTARPSDAQPSTGGSPDEDRASEDAPGADQATSSAGGSGFDHRAAFEALDFSGLATARYSMYERYFVIPGDPHEQRLAELEPYPYWMGRPRTVRNADGSESTLPGLNVLTEDPYVYPWEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MVT0</accession>
    <name>A0A4V6MVT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Nicotinate-nucleotide pyrophosphorylase [carboxylating]</fullName>
            <ecNumber evidence="5 12">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_915398</name>
        <name evidence="15" type="ORF">BD311DRAFT_810697</name>
    </gene>
    <organism evidence="15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
            <strain evidence="15">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12733"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Hexamer formed by 3 homodimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="5 12"/>
    <dbReference type="EMBL" id="ML143503">
        <property type="protein sequence ID" value="TBU23503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MVT0"/>
    <dbReference type="STRING" id="114155.A0A4V6MVT0"/>
    <dbReference type="OMA" id="DIVMCDN"/>
    <dbReference type="OrthoDB" id="10067394at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034213">
        <property type="term" value="P:quinolinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000090">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.20:FF:000003">
        <property type="entry name" value="Nicotinate-nucleotide pyrophosphorylase [carboxylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="entry name" value="Quinolinate phosphoribosyl transferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179:SF3">
        <property type="entry name" value="NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE [CARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase N-terminal" evidence="14">
        <location>
            <begin position="55"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Quinolinate phosphoribosyl transferase C-terminal" evidence="13">
        <location>
            <begin position="120"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU23503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU64121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="299" mass="33022" checksum="3348AFB85D9A8267" modified="2019-07-31" version="1">MSTSQDELDHYEHLLPPSWKTQITTWLQEDTPSFDYGGFVVGEAHREAFLLGKGKQTAVLAGAPFFTEVFAQLGCEVEWHMKEGETFEPVKHVATVRGKARHLLLGERVALNMLARCSGIATQSKKIKDLARGVGYKGVIAGTRKTTPGFRLVEKYGMLVGGIDPHRHDLSSMIMLKDNHIWSSGSITNAIKQARKVGGFSLLLEVEVGSEAEADEAIDAGADIVMLDNIEGAELVGVARRLREKWAGKRKFLFESSGNITEANLHERAINEIDIFSTSAVHQSVQHIDFSLKIQKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9ME15</accession>
    <name>A0A4Q9ME15_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_799224</name>
        <name evidence="1" type="ORF">BD311DRAFT_628353</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143475">
        <property type="protein sequence ID" value="TBU24678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9ME15"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU24678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7909" checksum="2B9F5EAA176BF79A" modified="2019-07-31" version="1" fragment="single">MQPGRQLQHLFAIKLVFQHPLNPRNLWETFKDSLCDDLCCTLIHRNYPDPMKEQVYSYGLYLLNEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MFC9</accession>
    <name>A0A4Q9MFC9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cerato-platanin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_908471</name>
        <name evidence="5" type="ORF">BD311DRAFT_779889</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143451">
        <property type="protein sequence ID" value="TBU26074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MFC9"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597577" evidence="4">
        <location>
            <begin position="21"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU26074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="16868" checksum="113F873B20E0CD13" modified="2019-07-31" version="1">MRIDLALLVASILCIGSAQAGPRYLAHGPVVTRRNVTVSYDTKYDHGSTPLSTVACSDGSYGMTTKGYTTFSSLPSFPYIGGADIIDGYDSDRCGECWRLAFDTSTGTSSINVTVIDQTENGWNIALRAMNDLTHGQGKKLGRVDAVATLVDRSDCGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MJI8</accession>
    <name>A0A4Q9MJI8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sn-1-specific diacylglycerol lipase</fullName>
            <ecNumber evidence="14">3.1.1.116</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_873667</name>
        <name evidence="17" type="ORF">BD311DRAFT_696209</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
            <strain evidence="17">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a 1,2-diacyl-sn-glycerol + H2O = a 2-acylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33275"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17389"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.116"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:33276"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.1.116" evidence="14"/>
    <dbReference type="EMBL" id="ML143429">
        <property type="protein sequence ID" value="TBU27724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MJI8"/>
    <dbReference type="OMA" id="EANMHMT"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046340">
        <property type="term" value="P:diacylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052214">
        <property type="entry name" value="DAG_Lipase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45792:SF8">
        <property type="entry name" value="DIACYLGLYCEROL LIPASE-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="16">
        <location>
            <begin position="522"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="423"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="446"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="497"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU27724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU61216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="776" mass="84274" checksum="076A24AE078CDE16" modified="2019-07-31" version="1">MLSNLDKYGRFSLDLASTATTIGFSTAKACTRLGFSITRGVASTAAGFTGSVIDYALFGGTTGAGQLLGGAVSSAISAVEFVALAPLILGESLTSTSLVAAHSSLSMLTTIFPGSDEASFSLASFVGLVRREWNEPAESEGLPEERYGLGEVLRALAGFAALQGVTSRFQEERWFKFMKEVPVHDGSSSFTRRKRVDSRVTITGDTIYPSHSGQIVTADITEVPVPGSWPPRQSTSLLAPPHTNLPSQGPEVAPPMDDLKQTLRRLSKLVLAGYGGPSLLFFGVSLTPWQKEEPKEEVKLADAIDASEKEAAGEDGRGRSKPKDTNMPGAPTYSWWDVLMGKHDHDIFMHWAQLQPTPSSSSTEQPPHPPPTAHVSSEHHIPRFWVLTDHVRKEVVLVIRGTMSLNELAVDLTCDPAPFTLPTVERSSSSRARTPSHLSQSSTHLQPDRGEETSEQEKRQPPLPTHDEADSDELDEELENIPGSFPFPIDISVPFPRSRKNSTRSSHAPRSRLASEAGDDTVYIVHGGMLRMTRAMGGPGKPVHYAVRDALRKNKGYSLVLCGHSLGAGVAGLLALLWATPETCLTHRASGLPVGRRVSAYCFAPPCLVSPRLSAKAAASGLITSFVNGHDIVSRLSLGSVRDLTRGAVWLCAAENRDGDKADGYSSVTKKALKWKMGRGEEGDEEWFLAIRKTLEANMQMADLFPPGRVYWALRDGDLHRAHQIGTGSGRSSPKEKVRLFEVKDVKQVFGQIIFARDMLSSHLPHQYDQVLHELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MLE3</accession>
    <name>A0A4Q9MLE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_570483</name>
        <name evidence="1" type="ORF">BD311DRAFT_663698</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143423">
        <property type="protein sequence ID" value="TBU28305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MLE3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11325" checksum="56F78FDC01EADC37" modified="2019-07-31" version="1">MKPAESSVLAFAPILQISTKASQRLIKIISQRRVHGRSVNAEISRGRETRGTMRRLLIPAIEANHVAEPFTAACSSHGPVGPSQVRTKTLATHTGDTAYNGYISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N497</accession>
    <name>A0A4Q9N497_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_616373</name>
        <name evidence="2" type="ORF">BD311DRAFT_861684</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145152">
        <property type="protein sequence ID" value="TBU56396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N497"/>
    <dbReference type="OrthoDB" id="2568455at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="485" mass="53687" checksum="462E4A5E1A44ABD5" modified="2019-07-31" version="1">MSTASYRLESPRPRPPPLPLRTGNLPARNSQILGHKDATETLLYDLPSSNPTSPTRLTSPTSPTTPYSPRSGRRVSKMTSPKNSRSNTPSRPMQSELEEFAELCRAWYYQQDDDAGRRMTQTLATLPPAQRAPFARLQASIRSAYHASVSARRDAEFKAHLNATKPGGSLMPHSRADPKGPLARKERYERLDRFIRTWCTMGMPGTKPFFQSLWAVMRLQVVPQELGGAGPYRIEWEIDDAVFKESGGKDFMLEAIDVLKGVLAFEDTASLSRTPSTNSPAQYPAFAPLSPIHSRSQSQPSPTGERTPTARTQKHPPIASTTQTKRPRAPSDPFLDTPTLSTSYSSANTALSTSGSSAADEPITPTTPAAEIDDLFAPAPTNRDFAESDGCYLRTWTAPDLSNPEFLNLLTLFPSFIAQTAAPRFPVTAASRRLADIEEGQEEEEGRKEIRVGTGTMWLGPKRRADGYQGGWWTRFRLWLARLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N670</accession>
    <name>A0A4Q9N670_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1003663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145292">
        <property type="protein sequence ID" value="TBU51700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N670"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="138" mass="14959" checksum="D24437CC14D61526" modified="2019-07-31" version="1" fragment="single">GPEPSTRGAQSWAERLKRRVSVTSRTPLPSSKPSVLTSRGPSRSLATATSLLARQTPLHLPTPSVTSSDSHEDIIMVDESTSRAPDALLNNSITPGYASDAAILDRIRQLAADLRAAFARSFVEERHRCPRTFIELGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB14</accession>
    <name>A0A4Q9NB14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1039680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB14"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="58453" checksum="AD7086E6E51D0519" modified="2019-07-31" version="1">MKESSSSSQTAAPAPRLASSPFDKPDADIVLRSADGVDFCVRSHILIEASPVFESILSIPQPQMDGRPIIDLTEDHKTLDIILRICYPIVKPDSPRSLGEIELAVKAALKYDTELPLSVLKGELFSLSPTNPIAVWAIGCRTGLEDVARRGAAEIVVRQAPLNVAVGDLEGVSAGDYYRLREFHRKGGKVEDGFRLISSSTETPSEASGTSGYVAAPAEAPYPDLVCTSSDGIEVLAHRGFLASASPVLKRQIDGLAKPTSGSDLLVLRLSEPAQLLKSLLGLCYPGQVPDLRSSPSHLAAVLAALEKYEMQSLRIAILPQWEKITGAEPLRAYSVAAGLAHLRDCAKTAAKYTLSASLEGRYVMEMESASALAYHHLIAYHTSCRAVANELLRPLLPEPEDKLSEYHRDDAWAASPRVQMKKGKKADCYYHSKCASQMEVPPNTSSQDVWLTNYIEDVVAKTEAHPNDVPLVPSAFEAALTAGQWCRSCSTLATKLSAIDTALRAIGSRIEQASITCTCAVSMRVPDAHLTDISGVLTRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB27</accession>
    <name>A0A4Q9NB27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_725236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB27"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13200" checksum="F3EE25150B95A4B9" modified="2019-07-31" version="1">MADIKEIAGHLAGLVDQLPLIYVTFDAREANFRFDFGDIGCALHKHPRSAQTIRPPWLHYELTTARGGSRHADPVPIWLKNPSGQDPERNRAALRRALELFRDTPTAVMVQVNVEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCE3</accession>
    <name>A0A4Q9NCE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Microtubule associated protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1043298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145274">
        <property type="protein sequence ID" value="TBU51968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCE3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NCE3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007145">
        <property type="entry name" value="MAP65_Ase1_PRC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321:SF41">
        <property type="entry name" value="FASCETTO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19321">
        <property type="entry name" value="PROTEIN REGULATOR OF CYTOKINESIS 1 PRC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03999">
        <property type="entry name" value="MAP65_ASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="695"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="792" mass="87077" checksum="51D90064C7FED4DE" modified="2019-07-31" version="1">MSTTITSLLNSLHTHLQSQTQLLPTLHAQLGLPPTALHDELSALQQQLTQCIEGQIELRRKQVDEWMEKCGAVEDQCIRYGKALGGHLKSSGPSVGEIRKEQVLPRRFELVSDYHEKLRQQYHTKLEQLLNLTSRISALANTLGQDFYAADILEPAPAIGENEYDSTSHRDVTPERFSKLEKELVRGKGEVAKRLTQLSAHFVQIDWLYTELGITPPSLDDLPTASSSTLGLPPLPRPGSSCGSRTTGPDPFLSTSMSIPMSTPTPASRLKPLTPLLFLSDDTPQTTEVDHQRVFAKFVARMEELSDEDLPDSNVAVGLEGVEPTPALMAWAEATRADLEETKKRREAHIQAMYDQLEALWRRLGVTDAEMDAFVEAQRGSTDVTIKAYEEELERMLELKRERMGTFIENARTEITKLWDELMVGEEERADFAPFFDDEHTEELLSIHEEEIKRLKEERRMKGPLLHSIKKYFDICDDEKELAASASDQSRLLGRGPRDPGRLLREEKMRKRVTKEKPRLEQDLLMSLPAWEAETGRAFLVHGMSMLQFLMDTVSVSDKENANKRTKGRAGSVPPRATTPANGSNHLAPPTSGHGKSGVVTPAIRPASTLGSSHSAPNKRPRLGEATATHTNRAPLGSSRGPSVNRAASPTKIPLPGKTPTTAAGSSLPRPVSIAMPVPKPGTAHHALGHGRVPSAQQLGSSHSYGMYQPGHRAASYMSSSTSSSSMYASGTGRYGAPAPSAAAVAKKASRARRESFKPRPSVDEDWAADVGLGGRRWAGFAGAVKEEDEEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCU2</accession>
    <name>A0A4Q9NCU2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="8">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_1023488</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="8"/>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCU2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NCU2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF17">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="9">
        <location>
            <begin position="23"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="25069" checksum="BC65F61054673272" modified="2019-07-31" version="1">MQPSFLHLASLILAASSVSARTVLSAIAVNGVEQGHGVAVRVPTSTLSAITDVASNDVICNTNFIQPMSNVVASVPAGGVVAAEFHHTSAGYTGPDPADPLDPEEKGPVLAYLAAIPDATQAGVTGLQWFKIFEEGLNTTTHQWGSDLLFINKGYVNTTIPSCVKAGQYLLRVEYISLIQAAQYPGAQLFMSCAQIEVTEGGDATPETVSFPGAYTPTSVVTDLYNISSYTAPGPAVFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFB2</accession>
    <name>A0A4Q9NFB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939451</name>
        <name evidence="1" type="ORF">BD311DRAFT_756735</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143413">
        <property type="protein sequence ID" value="TBU29472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145237">
        <property type="protein sequence ID" value="TBU52785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFB2"/>
    <dbReference type="OrthoDB" id="2748081at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU29472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9838" checksum="789EB67A31F02FB6" modified="2019-07-31" version="1">MRGKSAGLRIKHVQSKIREADVFIFPPTVTLFRPGPWPPRRCPWTRPKVRKRTESGRDEVYEGTFNEWMNLLSSRTRHEGSTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFC3</accession>
    <name>A0A4Q9NFC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hexose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_815348</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFC3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="520" mass="58659" checksum="DB05EB1B0DB3A151" modified="2019-07-31" version="1">MAPGAVVTTSSPTGFMHLIDPNRKWYNNRRLITLHAWLVLLLITSSTNGFDGSLMNSLQSMNQWESFFNHPQGGTLGLLNAIQNIGSLAGYPFAPYLSDGIGRRPSIWIGAVFMLAGAALQTACQNIHQFIGARFLLGFGLSIATNAAAMLVTEVSYPLYRPQLSSLYNTLWYSGNIVASWASFGTARINNDWAWRIPSILQAIPSFFQFFLIWFVPESPRWLISKGKDTQALRTLAHYHADGDERDPLVIYEFEEIKAAIKLDQENKNRVGWKALVATRGNRKRMVIIVAIAWFSQWSGNGLVSYYLNQVFDTIGITDNLTQLLITGILAIWNLFWAVFASFQVDRWGRRFLFLTSAAGMTLFFTLQTVCSAQYALHGTHSAAHAVIAFIFLFYAFYDLAFTPLIVSYTLEILPYSLRAKGYNVFNFTVSVALIFNQYVNPIALNAIGWKYYIVYCCWLAFETVFLYFFVVETQNRTLEETAALFDGDDVVKLQQIAHQAAEVRSEDYDEKGSDPGLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHU8</accession>
    <name>A0A4Q9NHU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mitochondrial F1-F0 ATP synthase subunit F of fungi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_853171</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHU8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHU8"/>
    <dbReference type="OMA" id="TIDYQMH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="97" mass="10232" checksum="B6432BA556DCEAC7" modified="2019-07-31" version="1">MQPTLIRRQLGGLVPPKVATPSLLSSGTGAGLGPLVNFYSKLPKGPAPTSAGGIKARFFNGKNASAAPLLFGILAIFSLGYTIDYQMHLKHHKNHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NM39</accession>
    <name>A0A4Q9NM39_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_393475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NM39"/>
    <dbReference type="STRING" id="114155.A0A4Q9NM39"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="743"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="875"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="910"/>
            <end position="933"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="946" mass="98755" checksum="27728BE43487AA69" modified="2019-07-31" version="1">MADPAFPLTIDDTSPLVLYTPFADTFGPEQTAQGWNPYYTGSGFATVDSGAGSPVDSAIGNGTSLHITAADEAALQITWNGTNITLYGTLVLASSDDLPEATYTVNLDGITTTNFLSSLPKPATVVDADTDVLVQFNSLQDGPHTLQLTFHNPDGTASGGNATSGPFIAFDRAVVEVGAGMPNPTQSSSLSSTAASSPTASASAVTAPLPDSATAYRGQWDFDTNMLPGSSASFHTSTNIGDKATLMFNGSAVGLTGLTTPDSGAYNVSLDSAEPVTLSGRASFTSSEPTLLFFRTGLDPSVMHSIEVVNAGPSGAGQGAGSRLVLGAVNVTTIQPPATSVGTAKGSGLPRGDVAAIAIGVTLAVAALAVVLFFFIRRRRRLSRRKRQMLVNPEISRAHNLAFLFPHRRHSKRGERDPQRALGGSYEGGVLDIRSPIPEEKADESDDSEDGHGEVDGQRLSAAEKGKQRATRQSNASKNSDGSYSIELPDLTIAQVPRGYLPTSVVPSTPSPPRTVSSPTSPRSPTRPRGPRELPGRESTTRGILLSSMPPLPRVEVTDEGQLVAPVPSYLPEAHISPLRVEFASNVQARPEGRTERTISTGAISLPQSLKQALAQQQQQQQQQQQQATVSQTSEPPSPARSNLVYSFLDFASTASSLSRSQSKSTSNSTGKSRSSSQSKRKSDSEHSKGNTASEHSQVVNWATLPPNRRISLGLSMTVGGATASRPSLMTNVSLHPVPLSQSAPALSVSTEHAPPSPNTPQIEGPDQDFPYDANQLPSPTDSVPYTVSDIHFRHSTHSSISMPAESRRQSGYRLSGSHRPPHPPLPSAGPASPTRATHQRGGSHSGSQSVPPLIVQRILGRTPSSSPASPPFTSPTTPQFASVAGTTAATRATGSSSPTQLRGSGSGTGPSSSNTNGQSSPAPAPTPGSATTVFGFQLGRRSERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMN6</accession>
    <name>A0A4Q9NMN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_939184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145232">
        <property type="protein sequence ID" value="TBU52918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMN6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13220" checksum="F280B3CFEA64AF93" modified="2019-07-31" version="1">MLDLACMVAFPVEVRGQEGTIRIRVWPVQTRARIPTFPSADRRPRTSVSIAEHAEVFGIRRGLCLSPSSVLKLLQFLVAIRVPHPSFSVISEEGSRMLHHASQLYRFCLLSLSVFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSA6</accession>
    <name>A0A4Q9NSA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_918310</name>
        <name evidence="1" type="ORF">BD311DRAFT_748634</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU62856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9NSA6"/>
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    <dbReference type="OrthoDB" id="9895617at2759"/>
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    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11894" checksum="DADDB239DDFB0121" modified="2019-07-31" version="1">MGFFHHESDEAQAYDQVVNAPHKAELSHELIAAAASYEAAKAYEKHVAASGQPPSHAKAKELLAGFAGAFIDRIVETKGLDYVDKQKAKHHSQQKVDEVVTVDNYNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NU25</accession>
    <name>A0A4Q9NU25_9APHY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NU25"/>
    <dbReference type="Proteomes" id="UP000292082">
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    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044328013" evidence="2">
        <location>
            <begin position="27"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="17621" checksum="C46692682AF13BBE" modified="2019-07-31" version="1">MVQTFILTRSFAISALVIGAFPVAYAAPVPKVVVHEARHNPRGCRLMGCLYALPTGQEDTNATNSASVTTSQTTLSTDSLQVIDFLISTLTSARNSLSSSSTSTSAVTVDAVVPSVDIGEDIADHSFAEELAASLSSDMKAPSPPPVAEATVPTAEVTPAENEAASLDALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUG3</accession>
    <name>A0A4Q9NUG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_937274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU53814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
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        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16425" checksum="B732ED0C57723E67" modified="2019-07-31" version="1">MADKNLPTVQSIPPETLDFAHRMFDAARDNNAELLLQAVDAGLPPNLTNDKGNTLLMLAAYNGHANLVKELIKKGADANRVNDQGQSPLAGAVFKGYDDVVRILYESGADPRSGTPTAIQTARLFKKDILLNVMGATKEDLEEPVPAIPGPPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NX07</accession>
    <name>A0A4Q9NX07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">BD310DRAFT_917162</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9NX07"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043478737" evidence="3">
        <location>
            <begin position="18"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="430" mass="46112" checksum="E3BC9AFB2E65C112" modified="2019-07-31" version="1">MVVFTSYLLLPLWVALAQSVLVNYTIDDEYGDEKTGVPPAYTPPIYWEQGLDDIPCGLSILQVDTSQVYRQTWHAIRWQDGQDADITVIFTGSAVYVYHMVANIFPAVDTSSQLSFILDDEVAGQYNNVPDASCSILYDVLVFANTTLENVAHTLIIRGRGTTPLILFDYLVYTSETEPNVPAPVSSNASASSDTSALSNTSVSSNASVSSSPRSVAPSTSKLRRTFNSDASASRRSPPAITHSPSKPQTQSRPPAEPTTSTAASPTLDPSSTRRRVPTRAIVGTTIGGVSALALLCCLLFCKCRRTGRQHVRTAYRKEATESTTSVVGADSAQPETKSVLDIRYHATAWKPLVPLNMRRESSNSPSSGAGVATVAAYGHSSDPGASVAAEEAPSRHALQKDIVAVREELAQLRAKFSRGGRAAFNHVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NX88</accession>
    <name>A0A4Q9NX88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_911162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NX88"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="177" mass="19823" checksum="EABF29051B651440" modified="2019-07-31" version="1">MSMRVQRRPLMHTKHSAHSQGTTKSWLARAANRLTSILSPSFPVPFSELPPRPVQRQVPITTIALKNRTTCYARPRVLSPLQIAPCERVVALRSGLADPLLHQRSFLRNFLHQVSNHRGKAATFTCLQPLSLECHSNPRAWLPLRRGTLAAPRPLPSPPSLRHYIGALAPERACLCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1T4</accession>
    <name>A0A4Q9P1T4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptide hydrolase</fullName>
            <ecNumber evidence="14">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_536931</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="14"/>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1T4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03875">
        <property type="entry name" value="M28_Fxna_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000008">
        <property type="entry name" value="Endoplasmic reticulum metallopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053974">
        <property type="entry name" value="ERMP1_1-A_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048024">
        <property type="entry name" value="Fxna-like_M28_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147:SF22">
        <property type="entry name" value="ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="METALLOPEPTIDASE M28 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22249">
        <property type="entry name" value="ERMP1-TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="15">
        <location>
            <begin position="140"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum metallopeptidase 1/1-A TM" evidence="16">
        <location>
            <begin position="421"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU57683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="866" mass="94766" checksum="E11FD377C11D1974" modified="2019-07-31" version="1">MSKAPRSRWGPVRSLLVLAPLFIAGPFYAYQKHYGLPEPVTELINPATSLPQLSEAHILAHAKYLSEDIGYRTVGTSEHAAGDAWMLKQAEMLCEESKEVLRAHPERKLQCEVWHQQGSGSHRFDMMGKRLYKTYVDLTNIIVRLSDGTEDGKKDAVLVNSHVDSTLPSPGAADDALSVGVMLENIRVLIHKPDWEPKHAIIFLFNNAEESLQDGSHLFSTQHPIAKTVRAVINLEAAGSTGRELLFQATSEQMVKAYSHVPRPHGSIIAHEIFSSGVLLSDTDFRQFQLYLNVTGLDMAVVGDSYLYHMRKDLVEHIEPGVAQHMAENVHGLLLHLTSSDSPLPQLASTGYTKPQIVFFEHFGNFLVYTFTTAKILYSVSFVLALVVARFTFVDPAPALKKSTSFLGEQTKGIGAASGAFIGAVVGANAVAFIMDKVLGKSFSWFTSIFAPLYLYGPAALSGALVSQLIVGHVQEQTAFSSIMIVQGFLGALIQLLGFGSSATLFMTSSPMIPALILNALLTSPGDDISLWSYAISVVTPLIAGTSMLYSVLDVFVPLTGRIGEEAPAEFVIATIVSITGSFILPLTVPFVHRFSRRTLIRLAIFTSMATGLAMAIFSMRAPFDPMHQRRLFIIHMENITSAEQHLHVAAADGAPGFHDLARDIAKEFSVPGVTPTTVVMNDWNSDWDTIYPFSAFLTPYKFDLPLRAEHQDPLDPGFKVTAVNNTIDEVAGTRSFTLVVTHPSIIWTAIAFDAHVLKWTLDDHPPDEFARHHIKEGSFYGHDTWSVDLVIKLPLADGSAPSDSSIKVNFMGIHEKAMWPGKRAEKALGGRAMKLFEEFDGWLERETGGTVDALLLGCVGGVAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBH0</accession>
    <name>A0A4Q9PBH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_261617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145267">
        <property type="protein sequence ID" value="TBU52080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBH0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="489" mass="51873" checksum="9FD0FB0C582A7C5B" modified="2019-07-31" version="1">MMRPKTLFDILLIQYVMSRDLRLRATPCKGCLRPLIKIEAGLPDAEWLTSIARSEAGASLHDSPVVPTAYPMSVAQSPTPSVGHLKYVDPTSGPMQIDRKHAALVNYTICIATVLFGIALITVFALIIKWRKRAADRHLKGSANTVVRNNTISYLSPARRSLTPKFPPPGLSYYESTLSPLALPPTTPPPAYAATHVTAPCTCPACINGTLPTYPCPSPASCATSSNSSPIETSSSAYDSALRTPKPTRFAGVISALRSYPTSANRSPRTPSPNENAVRRSFRRTPPDGHVRSSQDSPLAVHGQARAVQDATSSSDSSASLTFTPPSDAFDTPSRQVSGVRLPALQELSGDGDTNALCHDGRTGSSIRARFPLDLAVSRGYLAHILVSPPSEDRLDALPDTGDSELAAHTITSATGTTRGCAPGPGSSGTKAPETIEDGLDDASSAQTSAAHPRSEAWFTEVDWFGKEGPLAKYDEHAPATASLYGQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBL3</accession>
    <name>A0A4Q9PBL3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1043569</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145332">
        <property type="protein sequence ID" value="TBU51375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBL3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBL3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="171"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="4">
        <location>
            <begin position="344"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU51375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="807" mass="90708" checksum="35CB337BACB3968A" modified="2019-07-31" version="1">MKIRLLDTWTGQFVVEDPEKIKYAILSHVWDDYEQSYQELRDIQTSYDARGRLYFSRVPVAITRRALQKTRAVTAGQSFTHFLLDVNRLQLSLSHHPLVQSGVQFLFRHTAVVDYVWWILFLSLSTIIEDASLAVFSSFPALLACIFGISLPSAFLLTVLGAFSIWDDPDLSPKIREACRVAREAGYQYLWIDSCCIDKTSSSELTEAINSMWLWYGRAQMCYAYLADVPSGKNPHEPRSAFRKSRWHKRGWTLQELIAPSGVTFLADDWTEIGGKHTLFELIEEITGIPYQALLHAKSLDEFSVAQRLSWAARRQTTREEDRAYSLLGIFNINMPTLYGEGSRAFRRLQEEIVRRIPDLSLFAWNQYIYRGCKPDQDLVQALENAQSFKTWAPFEGTSTPFGSTISDFTAGGKIKAIPHDDVFRRLGLKDLPVPEYTSTSHGIRTKLPLVPLSSALPERPTEYSSRAPLQSQWYLVILGCEHDDYPGALLGQVCYIPPSESGVEYLYHGFVKISPDPESLPEYYSLFPLSPATIARCREHIAVKTVYISKPERALAQSEDARRQPHKTVNLVLLRKTRDALRAQGYTAELRGPDEDHPNTHWLTLSNDDHRIAVEYQHTLEDEDEGQRLRLKANVKVLRPTPGLVEEMEVVSGSMKWSEWSSPQFQWYESLPIDSASDQVALSAKQLTVQLAFDWAGLSHYFLRVEVVTETLQDTAPTSPESAQAEELQASGTDDEKGAQDVEVEAEGSGGVRSTTDDARLGTVDSEGSAGRPEERSVGEEGGARSEPHGGNVDGELVEGEEGVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBY2</accession>
    <name>A0A4Q9PBY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_244889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
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            <dbReference type="EMBL" id="TBU52280.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="125" mass="14087" checksum="44220776CBFC229D" modified="2019-07-31" version="1">MLKPLLRRAPIDLTLYLAFTAALLTRAASCFSSSSSYVSYSPSIVCRRVISRYSASFLSHRSCYPLSQSMPRRPFVRLTTQLTHHYSLDYLQTSISALMHLLFCPRLDGLQPSKITSQGRAVSPR</sequence>
</entry>
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
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                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
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        </source>
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        </location>
    </feature>
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            <dbReference type="EMBL" id="TBU50997.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="87" mass="10072" checksum="336511A5DC494FE3" modified="2019-07-31" version="1" fragment="single">RDSGEGSNYTKERILLESVLVLIYRNCHANMERNFALPGLSTRHAKKDMRKTFHEILKHMEERGPNEYRARRKSKYIIPDAVGKGAA</sequence>
</entry>
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    <accession>A0A4Q9PDK1</accession>
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        </lineage>
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                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        </location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
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            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="37449" checksum="B728AB8565F84A3F" modified="2019-07-31" version="1">MSPRTAFVTDHDPFAPPRSEIASPSAQPHPAHIAGRSRKKSSPLRVCADDREHGNPSRDATRPASGHVPGPNVAVPPASSFGKHVPRPPRRVANEPPERFTPFTCVPRSWPASCTPPASAPPHHPPHSRLSPRARARARSERSTSGPVRSLEVSGRKTWVDSHAGPSRREGRRQRFLPPLSRTGLGRRDRRLAGSYAIPRNRRTALERARQTHGTAARPVLLSAQRTGTRCARLGERKKSSGCTSASPQAICASEPMPDSASQRPPTLMSAVEPPVASWCALRRQAAAQHASARGNGGGAEQPSVDALCGLLILGCVSRSAVRPRPGELIGGASAESEKGCCTGCVWQDTT</sequence>
</entry>
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    <name>A0A4Q9PDT0_9APHY</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20593" checksum="E75CFDF1497438A4" modified="2019-07-31" version="1">MDANDPDNVPFGFVDPDDIIQLTYLIPAFEHGGTTDLLGPSKLARRLKDDGDDDDDWRYFYVCGPTATYTCGIWAVVSGIGVWVWVLKTPEDTPSGSRDVAALARVNLVPESQTPLSPLAGIAATWPRTQTQTQTRTRTRTRTWSHMQARQNRKEESDQMRRQTKMCGPVRERVKPAARLKMT</sequence>
</entry>
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        </lineage>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
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    </dbReference>
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    </dbReference>
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            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
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        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU21174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="22602" checksum="1D030745B1909E73" modified="2019-07-31" version="1" fragment="single">QIFGNASIGLASIAPSLRTMAVWSQAWYIVASLILVILGHWSLLLHGVLVEAAWIPGTGCAITQTSNRILAATFIYTICFNFTVLTLMAVKLGVGSSSRRDRSKIVKLTFDDGLFYCVVAFGAYVIATTFMLVNLNAVMSIIANVPAAIASNIVACRVVRRLTNYTSEGAEVFGYIHPVATPCYVDLVLYVRLGLKLRRSHSAVLVVAT</sequence>
</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="8208" checksum="9FCC3E0FA9881F31" modified="2019-07-31" version="1">MRPELQGTSLDRRRKEYWDRIKRGLPTSSFVPPSAATTILAGRDRFSCVFSRFSELRGLDSTISSLHPAPVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF57</accession>
    <name>A0A4Q9PF57_9APHY</name>
    <protein>
        <submittedName>
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        </submittedName>
    </protein>
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    </gene>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145211">
        <property type="protein sequence ID" value="TBU53559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF57"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="217" mass="24155" checksum="5D6DE9482B1578A5" modified="2019-07-31" version="1">MAGVPGFVSTAGHPTLMPGQLSNYSTLSGANTGCVLPASGKENRIPSSQRYITRADSPLSSRRVRIPTQPLTPSPGRVLTWPKMAIHFNPQEGGVYFADVDQQLVESLRSGNECVFPLVQQGRAEFRILWPGYGHMAHTYNIPTVIHGRPITRRDLARHVVAFYRQFWEEARRAQVSPGNECWAVKRFDFDELVLVSISNCDGHDAVFQAVVEVPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFI6</accession>
    <name>A0A4Q9PFI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_961955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IFI6/IFI27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFI6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009311">
        <property type="entry name" value="IFI6/IFI27-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932">
        <property type="entry name" value="INTERFERON ALPHA-INDUCIBLE PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16932:SF18">
        <property type="entry name" value="INTERFERON, ALPHA-INDUCIBLE PROTEIN 27-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="238" mass="24583" checksum="5983F1F43617843B" modified="2019-07-31" version="1">MVSYPVMVTASSETCIEGLVPTDAKIDRQRNPSAENELEIGEGSTPEGQSPPYTPPQENLLHPTCTCPRRREPVNQTETATTSPPDGTDWKKVAKVVGGVALVGAAVPTLAVAGVAAALPVIGFGTGGVIGGSIAAGIQSTLYGAFTGGLFSVFQSAGATIVAPAALEVVAAAGAATIGGRMIGAAAEEESEERERDVNGRTDTRVDCACAQCVCDAFCACACRKWQRRRLDEETLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFY3</accession>
    <name>A0A4Q9PFY3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pyridoxamine 5'-phosphate oxidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_862790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145282">
        <property type="protein sequence ID" value="TBU51831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFY3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020618809" evidence="1">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="234" mass="25699" checksum="0E30C984FC155E22" modified="2019-07-31" version="1">MRFLIILSALMLGAETIAQARETLEEAAAFARQLVNSVSIGNMATVYPADHASLAGEPFSLQEYYARHVIIESIPRSTAYTGSDLTATIRSCHVNGSLTLLFLPISRHSQNVLLSPTHAASVSVWSDRPAASRPRVSLIGNVTVFPVLEETPDREAIQACYVAQHPDARWWLPGPREPHIAYWARFDPHSVYYVGGFGSEHFIGNIPLEMYQNASFPDHATEVGVGGRVLVTQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJB9</accession>
    <name>A0A4Q9PJB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_936522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJB9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="207" mass="23360" checksum="36F75CD25B9B5C6A" modified="2019-07-31" version="1">MRLFKRGSHGATGSVSNHGVLCVLVEGDSYVQNQGILTSADLRNCPLVCRAFSEPVLRAMWQKMPSPAALWWLLVPEDKQTTPWIPTKDLCEKVLNAEQCSRSTMISRRPTTPGFSVLCWTTTTDTWSVPPSKGLWYSHIAYIDTRFYSILTPRLQNLRLTYSRALDTTIPLCLPSDLDFEGIVSEVRLSVPGLQHLRIEPYVIPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJH4</accession>
    <name>A0A4Q9PJH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_858880</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJH4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJH4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="98"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="139"/>
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        </location>
    </feature>
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            <begin position="288"/>
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        </location>
    </feature>
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            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU54247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="997" mass="111131" checksum="B1C20A7B7F8C397F" modified="2019-07-31" version="1">MSTAPSSRSTPASRSSPAVPSTRATSPPTSPATVPEDAKTEDDLGNQIAEADFPRDEAEALEEDADVDGRLAQLETLIQKSGAYVKLLKEQMDQVKVIHGARRSSSTSHAQAKANGKQKAKSARKRVRVVSEDEEEEEREAKRAKAEQDGEKAGEGEERKTAFQQPALITGATLKDYQLEGVAWMAGLHQNGISGILADEMGLGKTIQTIAFHAFLRERTPAPFMVVCPLAVLDNWAKEFARFAPDIPVVTYYGTKEERAETRRTKMVMDEVDLEYWKNASGSHAAAQAAAAAAAPSRGKGKGKGKGKGKGAPRGRGKAATAGRGRATRDDDSSEDEVPASKSRGKAAARGRRGGRTLAKSRKPVSEADSDEFENSMIVDEEIPEPAEQRNRHPLKPYQKTNFPVVLTTYQIVINDRAELARYHWGFIVVDEGHRLKNIDCVLMREIKKIPADARMVLTGTPLQNNLAELWALLNFVLPDLFGDLSTFQSWFDESRLRSKLTSDRESKLIHSLHDILRPFLLRRMKADVEMSLPPKKEYVLYTPLSERQRELYDVVVRGDKALRRYLIEQIGEEEDRLNGGGRKVEDDEEETPLKVVVKNGARKAKGLREKVERDYLESSDEEGEGYFKRLDEGRVEARREKEKSGGDIGLEWQRRVAVKEVNNKNLKNVIMQLRKVCQHPFLFHWPRDPTSRESVLGEELVTASGKMMVLERLLDALFARGHKVLLFSQFTTMLDIIEDWAIEHKGWPISRIDGSMDMESRREDIRRFQEGGDASDAPRLFLLSTRSGGLGLNLVQADTVIFYDQDWNPQADLQAQDRAHRIGQTKPVLIFRLLCAHTVETKIMQRATDKRKLEALVIAKGEFVNPTAAKRSKNQALAELAMELHRLEGEKIQVVPSDEAGRKSVISDEDLEMLLDRRPEVFADRQKGWTSGGQVEGELGAAEAGEEEKVLEPAAKGVVPDAQAKTRTAFAVYEAPVNADANMLGMMDGLEDEGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJK0</accession>
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        </submittedName>
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    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145192">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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            <begin position="29"/>
            <end position="47"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
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            <begin position="151"/>
            <end position="169"/>
        </location>
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        </location>
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            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23226" checksum="DD8A47E94DE6FA5D" modified="2019-07-31" version="1">MLVDSDWVTVITALAVHQVFRKIDTYSTLFHAIFLLCPPVLITYFVTDATSSSIYQRTLVSCYGVFYLALALSIVAYRLSPSHPLARYPGPFWYRTSSFCHAFLSVSGQRNTYLKALHERYGDVVRTGPNELSIRDRSATTKLASLPKGSMYIGAFLGQIFPLVGISTVEFDRRRTRSTPAGLEPRTWPSSAETGMGATSPSPTPSGPSDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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            <strain evidence="2 3">CBS 464.89</strain>
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            <begin position="77"/>
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            <position position="104"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU54576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11899" checksum="088C4153D2166998" modified="2019-07-31" version="1" fragment="single">MVVWSLFWAAVSAYTHVLSYLSWLYATCSDHSSRDFLTTTKSMYEVGCKTASMRIDGPRWTCDITSTVGFPYLRYDVAVIAIIICIFVVTSILGIWDNELKYMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLM8</accession>
    <name>A0A4Q9PLM8_9APHY</name>
    <protein>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8389" checksum="DEDFFC5C0BBA8FA8" modified="2019-07-31" version="1">MPVLSFTGESPFASFSASSCFFLFRIRARVHSWRCIVIPQCSSLVEHPREAQYFRSGLKLQNSSAYIGNEIILC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMA9</accession>
    <name>A0A4Q9PMA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="2" type="ORF">BD310DRAFT_690800</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55284.1"/>
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    </dbReference>
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            <end position="224"/>
        </location>
    </feature>
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        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="224" mass="23797" checksum="99DE395F79F64F6E" modified="2019-07-31" version="1">MTAFDGHASTDMYVTNDRDNTCHDGSHACHLLAMGQRCACGDPYPTRFKGGARCTSTAAAHTPGSKANSTGRASMASNPPVLATKLMAHADVSTTYRPFQCLMCFGAKSSSWYVVGRSRCLLSGVPSLPRRPRVRLPQISDVPIVEVATHFVSTQIISPSLVSQHSALTCSSFSSTVPAPASSQEGCTAKPAVRLTRNTINSDKTHALERTPTSEKSDTIPNVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN30</accession>
    <name>A0A4Q9PN30_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_933301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN30"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="484" mass="51460" checksum="453E79F27E2E66E8" modified="2019-07-31" version="1">MSRATHTASAPVSGSVARTGRSYDAYRVPRELAPGFMDNGIISANHPIVQQFVAFAARKLLAAEALDAATGRAAVADRHRSPKHPEVTLWRLEEGGVACVGDVEDALGAPVPARLAEAIFALAALAVYAFPMRPAHWAFWAENSQKRVSGLIHGVVCECSDCVWSTGSWLTEDGGMSGADPKVIHVPNGVSWDSADRAVKDLRFWHKGWREEDTQGPLERRRSPRKPKKSASGDIPPSSATKQQVKNTNGKRPAPDDGPSQSTKRRRKAKDDMAGTNEETGTPRRSRRTRKEVQEASSSTSSSSMALAVDDSAGMAVDMEAVQAVEDTEASTAAGSQNPPAAKSTRRPRGKAAATRRPAAKRKARNTRKAPSGGSPCESPSLSAQSPITIRIPPRSATSSPAVATRELADGAPALTWDEPTVAASPWSSCDTAVEPSTGVTTRVGTPQPDLEGKVKPGSLRPKVAPEVAGRLSTKMGRRALRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNS8</accession>
    <name>A0A4Q9PNS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Voltage-dependent anion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_932847</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNS8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09318">
        <property type="entry name" value="TDT_SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF1">
        <property type="entry name" value="SULFITE EFFLUX PUMP SSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="414" mass="45417" checksum="74CDA396D73DE98F" modified="2019-07-31" version="1">MPLLQPVYAWKSWRERIRHFTWAWHAVIMGTGVVSALLHNFPYHNDSLALKIAALAIFLLNLVLFVFVCTCTILRYIMFPEIWSLMIHHPAQSLFIGCFPMGAATLINSALNINQDWGFGGNAFLWTLWGFWWLDSAVSYLIAFGMLYIMMTRQDHSIPKMTATWLLPVVTLIVASSSGGLMAHALMPHSTTLALVTSAFSFTMVIIGLSFALMMITVYLLRLITSGTPDPSLILSAFITLGPLGQGGFSLLVNGQDLSEILPLHMGDEFPTIALAGQMVFAGCFLGAYVLFSMGVAWILVAVITILHVRAQAEMPFSMAYWGLIFPNGVFALLCVELAKVLDSPVFRAIGAAWCGVVFLLWITVFLRSIPAFIDGSMFKAPYVPDQGATGTKVTFDPEKGLGSNPNSSSTVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ59</accession>
    <name>A0A4Q9PQ59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SNF2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_768052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ59"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ59"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="230" mass="25946" checksum="854DD26E9B7BAE51" modified="2019-07-31" version="1" fragment="single">MLANDPRTQWVIEELDQVLHEIEVGPETEIEERPAEDIDISDWESGVEDLQDKSPDAVWDILGFPTKRFPGFNEVEDPTGALDPWDNKKWEAFIKKGQGVPFAPRWHQLVGVVKMMRQLIEGRPLLLMDQVGIGKTLQVVGTLCMYVAFRRHFARYGRFPGHFGKIPLAVAPDEPTADIGVDPELCLFGHSFGVVAMDEAGKLRNLNRQWTCFRELVKRGHAAIAMTATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQL9</accession>
    <name>A0A4Q9PQL9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1023396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQL9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021031868" evidence="1">
        <location>
            <begin position="21"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="168" mass="17902" checksum="4C19B678365BA3C0" modified="2019-07-31" version="1">MRSHLYLQALSLAGIVVVTAATVASQTSDLPPEFEAVFAGQMIGAPYTNTTGPFGLRVHAPLFGGNLTDVTSGEVVATMLPTADDGLIIGSATLFSYWVLPYVWETDGKLASMTVRGVGNTTGHSYCYVHVETDSSAYSWMNSNFFIMKTVGTAEPLVHNITLYGVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSL1</accession>
    <name>A0A4Q9PSL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_880768</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSL1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU57399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="565" mass="63864" checksum="99268022CCADD22A" modified="2019-07-31" version="1">MYNASATVGPNIDRRQDGDSPYSNYQRSKDVKNPRFAQACLFLAVVVLVRAQRRRKGNLPPGPEPWPLIGNIFDLTSKELWVRASDWASEWGDVVYLHVFGQGLLFLNSYEAATDLFERKGALYSDKPQLVMCNELCGCENITAFTGYSDKFRRQRRLMTKVLGPSAIPSYYPLLELETQVLLRRILETPEGYSAHIRRYAGSLTLRIVYGYRVTANDDFYLKLAEECGDILSNGIAGGGFIWLVDVFPFLKYLPTWFPGAGFKRKASKWKAKIEEFVNKPFDMVVARMKDGTATHCSVTTLIETSEDDNMTDAETDTDARWTSMSMYLGSLDTTITAVLSFLQNMMFHPEVAAKAQKEINSIVGPGRLPTFADRLDLPYIEAVFNEILRWSTPVPLGLPHRLMEDDMYRGMYIPRGTLVFGNNWHMSRNPALFPDPDAFKPERYLDKVDDATAIKMDPRTFVFGFGRRGCPGSNLVESSLWIVVASFLATFDIKKATDENGQIIEPAIVYDDAVFRKPNDFPCSIQPRSASAAALVEQVSALASVRCLRRRLPRPLDHRRVEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSU8</accession>
    <name>A0A4Q9PSU8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_929137</name>
        <name evidence="7" type="ORF">BD311DRAFT_349888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSU8"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF26">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU34305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU57480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="605" mass="68247" checksum="1EB3CA4EDFE012B4" modified="2019-07-31" version="1">MATDGYSEILPTLDRLGVSAIPADVDVRNVAQLWLDSFAKYTESGDIDGVLSLFSSDAWWRDMLALTWAFRTFHTAPKIRKFLEDRLSVNAPTNFKLTDAKFQNLYPDLAWILGQFTFQTKVGQCSGIFRLIPTSEGGWIGFTFYTNLEDLKDFPEKIGALRNPLPNHGKWLAQREREREFVDSNPTVLIIGSGQSGLDLAARLKVLDIPTLVVEKNKRVGDQWRYRYQALCLHDPVWSNHLPYIPFPPTWPVYTPAQKLANWLEFYADALELNVWTSSTVTKATQDANNEWDVTVERADGSTRVLHVRHLVSAIGLGGNNPFIPKIEGQEEYQGQVLHSTQHNSARDHLGKKVFIVGAATSAHDIAADYAEHGVDVTIYQRDNTYIMTTKRGMPILNGNLWWEGQWPTDVADRIEASLPTWLTEEIAKRQTAAIAEADKELLDGLHKIGFRTHLGPDGRGFTAMGRRRGGGYYLDVGASQLLIDGKIKLKNDSQIKRFTKTGFEFEDGSTVDADVVLFATGFDSPMVTIKKLLGEDIASRVKPMWNLDEEGELRNVWRDTGVPNFWFMMGNLMWCRFHSKHLALQIKAIEEGVLGGSGSEYRYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTB3</accession>
    <name>A0A4Q9PTB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_949247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTB3"/>
    <dbReference type="OMA" id="CMLERNF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="127" mass="13984" checksum="F995E05FE0BEC1E9" modified="2019-07-31" version="1">MPREHKIRGSEGRDFAMLERNLLSHLRLAVLLSLSFASLLLNTRLPTPSDPGSAQTPQSKTGLAISWMELMAAVLAIAAGLWEYWQGYIDMKTQRGFLRATQTHLAILSVVGIVVFASCLMLISTDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU76</accession>
    <name>A0A4Q9PU76_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU76"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8079" checksum="890C78B59C5FEA49" modified="2019-07-31" version="1">MRFLVYTVELYISSRRIAIRLVCLVASVRHRSDPLLTVRVDILSRNNLRLADVSAFSRIDEVQSSPTMAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVN2</accession>
    <name>A0A4Q9PVN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_977227</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVN2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="114" mass="13065" checksum="2AD725036CA79463" modified="2019-07-31" version="1">MRIVGSEVQHVPMTTQAYVLRGNDPQYLSNDIGGFHHSRPDGLVVHYYATSKGEDDKPYRDPERLHADDVELVDAVGRWNTKLKEQSLETHPQRRTTRDQATCGMISREVLFMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWP2</accession>
    <name>A0A4Q9PWP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_948305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWP2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="18650" checksum="3A8AA90B7FC9BCC1" modified="2019-07-31" version="1">MPLPGRLRSPASCLLQQPCNVWDSTGSVSPCCTLASGRQQPPRAISASPRLPLGIPSAYRYRHVPPHHQTQCRRTSTNAPEAFCKQARAHCYRLTCPPAPGVLHGLGCHLPAPSPASTSAGGETASVRLRDHLDARLCFGLAGDPSPVSVEDAVMDASLAERSGQALRTTSRILPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXC3</accession>
    <name>A0A4Q9PXC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_418376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXC3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020369137" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20387" checksum="676FB1ABA7EB5E70" modified="2019-07-31" version="1">MLHTLRTGLLLASALCCTPSRDTEIRDGIDTSVGNQCRADCARQPNSKTAPACVAIERKLAIAGTERQARTRPSRSRSGWRSVGRRRWREASPLRPLRRLAPPGSFGNARPLALRGDRGARRAEPTDAPPHRRWCRRNMHNMIAITVRQKTYAGPTRRGRACNHRHRTQLAELVRTAKYIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXX0</accession>
    <name>A0A4Q9PXX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8394" checksum="E588273E04499AE1" modified="2019-07-31" version="1">MAVWWTIRGNDSGDDSRGGNPRFWQNRVKSPVRVWRSTAHPHRDSLYSIPSVRPRISPSKIGYMSNYYWGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYE3</accession>
    <name>A0A4Q9PYE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNF2 family N-terminal domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_816520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYE3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYE3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="54"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="475"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="653" mass="72631" checksum="546DFDA40CBE547B" modified="2019-07-31" version="1">MTQADTEKALRDFVAEEYNDGGVQYTIEDATVEGFREGVLLLPHQIKSRVWMAERESGKKTGGILADDMGLGKTISTLTRIVEGRPSGKDKKAGWSGSTLVVCPVALVSQWASEVKKYTSGLRVVQHHGPSRSTDAYELERAHIVVTSYSVITSEYGAFAPAKNEGKGKGKGKKATVQDSDSDEDSDDFSKRLKSTARRGKQKDALFRVKWWRVVLDEAHNIKNRTTKSAIACCALDAKYRWCLTGTPMQNSVEEIYSLIKFLRISPLNDWGTFNTSIAKPVKAGKPVRALKRLQVVLRAIMLRRTKATLINGKPIIELPPRLVNVVECEFNHVEREFYNSVEQKVQKSLEQLEQGDFGKAYTSVLILLLRLRQACNHPALISKDYKGDSEAVSPQTASQNTNSQDDDETDELTGMLAGLGLGKKPCQVCQAPLTAENTWKEDVCVDCEELYKAARKAAADPNSGLPPHSSKTRMIVKILKETEERGEGEKTIIFSQFTSMLDLIEPFLKSEGIKFVRYDGSMNKAARDDSLERISKSKSTKVILISFKAGSTGLNLTCCNNVILVDPWWNPALEDQAFDRAHRFGQERPVNIHKLSVPDSVEQRILELQEKKRALAAATLAGDKLKNMRLGMDELVALFRATGHDDDDSEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ04</accession>
    <name>A0A4Q9PZ04_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_1038276</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PZ04"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="5"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="25"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="498"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1180"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="1621"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="347"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="825"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1018"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1143"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1032"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1081"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1143"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU59830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1661" mass="183439" checksum="B14C67698463A331" modified="2019-07-31" version="1">MGNAQSLTRTSGALDSFVAELGGDVVYERSLGSARFLKTVKCRHKNGYLVVKIFIKPDPGMSLRKYHRRLKIEREALAELPNVYGYQSFVETDKAGYIIRQWIASNLYDRISTRPFLSLVEKKWIAFQILNALRDARNRKVSHGDIKSENILVTSWNWVYVSDFASYKPTYLPLDDPSDFSFFFDTSGRRSCYIAPERFYTASENPDISAKKSRLAMEDSEGKRDGRVTEAMDCFSVGCVIAELFLEGKPLFTLSELFKYREGELKVDTQLGAVEDDGVRQLIKQMIAIDPNSRPTFDTLLHTSRGTVFPESFYSFLHNYVSTVNEVNYSSLFSATATPSTIPASATVSAHKGAGPNASASANLNGDLPNDPLPSDSDHRMERIWADYESVEPYLINEAVEETVMDVKIDYAPQPMSSRPFHDVLPVELNIPNRESKLHSAWSAGKRAAAEDGPALIILSLVCANIRDCYLPSSKVRALDVFLALSSHLTDEAKLDRMVPYIVDLLHDDAAIVRAAALRTLMQVLMLVTVITPSNAAMFPEYIIPAIAHLVRDPEVLVRCMYAQIIVPLANTAVQYLEMGQALKAHGTYKLSPDTQEYDEAHFEVSYDASMADLQNSIQEHLSTLLVDPSSVVKRAVLHNISSLCIFLGRQKTNDVLLSHMITYLNDRDWLLRYAFFDSIVDVAACAGGRSLEEYILPLMIQALSDVEETVVAKVLASLTNLCELGLFQKMRIWELMSATLGFLYHPNIWIREGAAAFIASAAKHLPPSDVWCILYPSLKHFLRSDVRDVDEKGLLMAMKRPLSRQIFDAAVQWAMKADSRTQFWRSHRSTKSESPRESVATVRQAGSVASRARSDEDEAQFSKLQQLGMSSTEEAKLLAMRDYILKLARAISSFASRVSVEVESDALKVTSTIELQKLGVVPQTVFLRNSESDGRPSRHRLNSEFTLRSPGTPRTHRTLSIDHGPSSIGAPFEDLRRRLALINGSHTSVAVPGSREPRSPVPRPLSIDTTAALLSPAQPDLPSLERPDSPAESTVSTTNSSAIRAMRFPIGGDGQKAAPAVGSSKASATGLLEAHAQILSEGSQSPSGRSSPVSIAGTVRGQERLRSPSIAPISSYDGQEPGISNMLEHLYLDNNRDLQDDFGPRVHDGPVRRRNAARHSFMPRDGSARRLEASLIAHFNSHSDAVTGLAVSPDHIFFVSSSDDKTVKVWDTARLERNVASKPRHTYNQHHARVKCLCMLEGVHCFASAAEDGSLHIVRVQVSQSGTLPKYNKLHTVREHRVDTPGEYITSMSHYGTDTSSNLIYATTHSVITILDLRTMRSLQRMENPRHHGPITCLCLDRKRTWIICGTSTGVLSLWDIRFGILIKSWKVGDSLKGKSGRVHQCVVHPTKGKGKWVVVAVESHKASNTDNQSHTLLEVWDIEKTMLVESFISRTVFNPSDPVEEPKEIEVNEAETSPAAAIAALVRARQESGSGDASTPRLGFIGAGTYGSEAPLPPFPDVHGIVAGAEFGGHTVMPRSHMAESDGKASSRSASSRGFIVTGSEDCKLRFWDLARPERSVILSGNETESDKPTYSSIRASAGSASTYAETWVASQSGNQHNRPPQRLSLINHNQQNLLKGHQDTITTLACIDSPFRGGLVSGDRAGVIKVWRVESFDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZD1</accession>
    <name>A0A4Q9PZD1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_359075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZD1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8595" checksum="F557BCA05266792B" modified="2019-07-31" version="1">MDRRERCKRRRFARLSLCTSCPLAIRPRLSRRCTIPFQARTQSALSSASQHRLNKDVGMHTVGLSRVVPSSPGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0H2</accession>
    <name>A0A4Q9Q0H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Agmatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_307815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the arginase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0H2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0H2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008783">
        <property type="term" value="F:agmatinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF30">
        <property type="entry name" value="AGMATINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="399" mass="42931" checksum="454FDF30AC981921" modified="2019-07-31" version="1">MIFSSSRISVVAIVVSQAVQALGNIQYPVGIVNAETFGSLNFTEIFAAYGGDMSNAAWARSAWNGLTTFARAPPLRCFGADFETGYDVAVLGAPFDTATSFRPGARFGPNGIRQGARRLGIDRINVPAKIRITDHLDVVDCGDVPMVLTDNKVALRQLELANAALLSKTSLRSYEGKSIAKDGQFHPRVLTLGGDHTITLPLLRGVAGVYGPVSVIHFDSHLDTWKPKQLVGGPWLPDEEIPVSHGSYFWYAHKEGLLAPNHSNIHVGIRGAINSWQDYDDDYAVDFIISHAWEAEDIGWRGIVEKIKATVGDNPVYISLDIDVLDPGVAPATGTPEIGGFTTREIKKILQGLSGLKVVGADIVEVAPGYDTQDEITSIAAANIGWEILALMAKTPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0J0</accession>
    <name>A0A4Q9Q0J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_359120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0J0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16201" checksum="4FF03272718C1D91" modified="2019-07-31" version="1">MFQTHIHGIFKCFQRWNRVGQWLRCGRVGARPRISGDPSTPPGAGHATLIFTSAVRDIGSLTRSCIQGGHHQYAAEGHTGNVSELHFRAATVTLQFHPRSFCCITTTPPPPWPRGILPVTSSATEVSPTCQKPRDQARSDKTHQVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0Y2</accession>
    <name>A0A4Q9Q0Y2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative zinc-finger of transcription factor IIIC complex-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_922760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0Y2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0Y2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044230">
        <property type="entry name" value="GTF3C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024761">
        <property type="entry name" value="TFIIIC_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024764">
        <property type="entry name" value="TFIIIC_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15496">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 4 FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12657">
        <property type="entry name" value="TFIIIC_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12660">
        <property type="entry name" value="zf-TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Transcription factor IIIC 90kDa subunit N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC putative zinc-finger" evidence="3">
        <location>
            <begin position="724"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="792"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="866" mass="93812" checksum="4AD79A7C8DEC2A29" modified="2019-07-31" version="1">MAELPLPTVLGLPAVSVSPSVQGLQFSQDGQAVLLTKYAVYILTPDLGVNVHSSVIKKITDIKPSPRGIVRPLGWLRTMIEYDRSLPHQWPIDCSEWGTVSLGSLDPSLWAATLSPSNLTMDAGCVLALLNSNLELTIWSASKNLLTGEWVMLEDVTSSLKIVAVAKTQGSAFKQMLQLQSTCIEWSSQPSWGLTPAPRVDASLLAVGNRAGSVTFLRYNRTNRRMVVVEEVSVSDRWVTQLAWSSWSLIQDGTCEAMLACGTSDGSVTILTARQTLTAKPGITQFVQTHQLHLSVEPYDGEACESDRRAITAMRWANVAERSPILIYHKAGVLFLWSPSFGKAAWSGSRTLLLRTQKRSVGSTALSPCSGISYIPTHDVCVVSLSDGSFHAIRNLFVDPSLDQSSSANVSSETLSAASRAIFVRAEPEKASFKDVDRTNGMTTFDGRATFLWIYEASRPTDFSYKHDAKHISTFVVAQLWEESFGDGVISDLAERVGHPSNSSGETPLSALRAILWQLRESVRIPRIHSGILKVLYQIPLSGALADFHIPPYAGDWTSDVSREVRESLTTHLFGWDSTQSLRMRYAVAVFCQVSRVDGDAAESLIHCVTVSRHRTTMPLQNHSEMPDVQQEFAKAASLFLAGVRNHVQATLIRHISALSELLNQDDISFAHRTIHQAATAGAPPTLAKEAEELRKQLLRSTPHPELSTDASTGTGARTLSSLDSLVEPCPACNVPIPLSPADPESAICANGHVWARCCITSYLLATPTVRTCIGCSRKAFQPSLTLASPAVNMHAAEPTDGDSHGDRGRDKTAPSPQDTGSSAVGGVGGSSSVLPNSARNSRVVRDLLDATRRCPVCGNNFVVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q180</accession>
    <name>A0A4Q9Q180_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947041</name>
        <name evidence="1" type="ORF">BD311DRAFT_773947</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q180"/>
    <dbReference type="OrthoDB" id="2205812at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU34078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33815" checksum="C862381B56119A65" modified="2019-07-31" version="1">MIRNSNLNGYKIPGKLEALKATLFADDTTVYLAENDDFADLQRILDTWCSAAKARFNIGKTDIIPIGEPEYRRKMVETYRETGAWKNYPRDVRMAGDGESVRILGAFFGYGLDQMDVWTPRIAKIAATVSRWKLGHAKLDGRRHATQMIVGGMSQFLADVQRMPGSVVKRLTKIMRNFIWDDRANTPVALPYLYQKPEEGGLSLLDLEARNDAVTVMWLKSYLDFGPNRPAWAYVADDLFATSVAANCVPTQRELREAEPPRRAERDVKSGQEIWCAARRISVLEGDNESYADVGPCVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q182</accession>
    <name>A0A4Q9Q182_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1037997</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q182"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="197" mass="22012" checksum="58129FAE60EA9DAA" modified="2019-07-31" version="1">MTPPNVTIELVERLTEPLTEEAVQLFTSLVVGYPCMMALTGGDWSILPDFGRATVRSLVLCPGASHMFTARDETRALVGFALFSLPGEPSTQGTHEKDDMSEYMSKLSPEGRQYFAEIGKDIPRSKDELFGIEAAERNTYWCSRAMVRADYQGKGVAKAMFEIAFGEVCNPYLTYTYRVAYGPDTHAESTQRRLELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1H4</accession>
    <name>A0A4Q9Q1H4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">D-amino-acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_813754</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1H4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1H4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF11">
        <property type="entry name" value="D-ASPARTATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020693176" evidence="7">
        <location>
            <begin position="24"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="51"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>D-serine</name>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="374" mass="40484" checksum="2C3B8981CA1BB47F" modified="2019-07-31" version="1">MSSPTGRKRVVVLGAGVVGLTTAVKIQEKGEYNVTIIAETFPTDPKTIMYTSLWAGAHHVSHAANDAKQMAIDRETFNVMWKLSEPGGAAEHCFLRVAQTDYLLDGRDECLDWMPDFKTLPQDALVPGTSAGTSFTTVNIDTPVYLPYLLARFLSRGGSIVRGSVQHISQVIEGGPGLFRRGRADPELVHALVICPGLGARTLGGVEDKDVYPVRGQVVIIRAPWIRSGRTVSHLEQGLWTYIIPRRSGDVILGGTKQDNDWYPAARPETTTDILERCLALCPEIVPPAIRAERQGTIEDVRALIVEEGCGFRPQRKGGIRLDVDWVPGRAGQSSVPMVFNYGHGGGGYQSSWGSASIALALLEKALASPASKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1T2</accession>
    <name>A0A4Q9Q1T2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_921315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1T2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1T2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="303"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1081" mass="117689" checksum="8862844975AE3EA6" modified="2019-07-31" version="1">MSTPPPSESSSSSSTNSPSPTTPNSELKSDPSETLEFLLQTMAAQAQAHAQNGESSSPFDSNGQPDWSQLSSWESTGQEQKFETTSDFNFSFPMDLDFDPNMAVDPSALHFTTIFEQSAFTLPPSESSFLLSNEMVHNNMLFSGEDFGMPHSHIEPGTGRRLSVTSSSSSSGASLSPIMEPTHAVSSSPPDVNLNDPASELAQRVRQMAGVTLAVPVSAQVQQLAAAGGQAKLPIPRLKQSPTPAPAPKRTMKPSPPPPEQAASPSSSSSSSPPPSSTPVSEHAPSPVTEIPSTGPTQTIIGRPKTSHTTIERRYRTNLNARITGLKQSVPALRVLEAKAGQPTPWNDVVDTRGFVDGVKVARKMSKANILGKATEYIRVLKKREARLKREQDGLKSLINGLVGGPALLKEWEREWRERFGGEEKDEIEDDDAAGASDDDEGDGDDSDGEDEEGRTRKKAKLAKPAKKEKPYRPPPPPPVPSVPGAVPEKRKRGRPRKIPLPPTPVSTDVSAAVTPAPTAAQPIFPVEQVMHDAFMQVKPERTMQQPPQSTSQQYLLAVFAFFSVFNSPLTSSHRSPAASYEHTHHGAVLTPHQPTATHVPVGTSARYGVHEAIQAAHLLVSTLVFFYVLVPWLSGTIRRTNLLSKVASVFSRSHSDTPFPTTLTSGSPAKRNALARSVLVDVLSPETRGSVDEPARLRSALGISTGVIGLLQSVIKAARRDRGIELNQLEQRAWVRLGELIAFDGSVGNMTRLQTFWCMSWHISTFAASTTDLSTLALIIHPVSSSKATELWERARQREVLRAHEKIVLNNMSVEGAADWLSKWRSWHEFERKGRCTACEKRTPLGILAAILIRERLRKHAASLFVRTVVRAEVEARRAGPAYDSDDECDEPMYAYDADKDYKEEQERKETVEAGKSIGGRTAELAVLLERIWDTGFSSQEESLVPLPRHAHAHARNPDVDADCEDDQDLASQDEAEIRALLTATLIYRRVFPSTIPACAVSAGRAPAFVLSPPPSPSRRNAQLHMALRTALGSPAFESGADGRLEDPELGAALEDARDRVVDMLVDFERACRRGGRALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1Z3</accession>
    <name>A0A4Q9Q1Z3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_975637</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1Z3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1Z3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="4"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="202"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="266"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="439"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="478"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU60866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="509" mass="56497" checksum="36AAD5C59A009013" modified="2019-07-31" version="1">MITASVSFCRNCERFLSPPSSWVIARPESQELLAICLKKLKGLNKVRLTEAHFIWTEPHSKRLRVSLTIQKEVLTATILEQVFEIEYLVQYGQCPDCTKLAAKNTWKALVQVRQKVPHKRTFLFLEQLILKHGAQKDTISVKEVRDGLDFFYSSRSHAQKMVEFLSGVVPVRSKASEQLLSADTHTNTANFKYTYSVEITPICKDDLVCVPPKLARSLANISPLTLCVRVGNSLHLMDPATLQSAEITAPIYWRTPFESLASVTDLVEFTVLDVEPSGATRGKWVLADAQVALSGAFRSHGAAGAGEDDTMDYEGGGDQIFHTRTHLGGILQPGDSAMGYFLTNANFNSDDFAALPSHRVPDVVLVKKAYPNRRKKNKPRGWKLRSMAKEEGEEGETGGGRGVVGRMGGRDQKKVEEDYELFLRELEEDEEMRGAVNLYRAQKPGAGSGLAGGKTRRKGQGQFDMDVDEHASAPDAGIETDAEEEPDFPQVKLDELLEDFDDMTLEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q319</accession>
    <name>A0A4Q9Q319_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q319"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11525" checksum="55361769547D0380" modified="2019-07-31" version="1" fragment="single">MVGVEFVSSVGPDLYNQVTSPAVLTKLASRVGSKGLAERLLTLTTSVYGVAHSVAKHLEGESHGTWRSSRRLCMRSSETVEQAVEGRRGGRPEEMSPKMIRYGGVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3A9</accession>
    <name>A0A4Q9Q3A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RraA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3A9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3A9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20475" checksum="124A74670A6ADE75" modified="2019-07-31" version="1">MLSPSDRSDRICGPAYTVQMVLGSNKDAPKLSAHFVDTASEGSVIVINTPERVKNAVWGGLMTAGAQSRGALGVVISGRCRDLAEHREASFPVFARGHSTLGQSPFTRPSEVNVPLVIRSPDVSDQEFPPVRVEPGDWVIADEDGVVCVPAEKAEEVIGLAMKGREVDARCLEDIKAGKGVQEAFKKHRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3F1</accession>
    <name>A0A4Q9Q3F1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BD310DRAFT_920345</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Preautophagosomal structure membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ATG27 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3F1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3F1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF13">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="17" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0732">Signal</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020933317" description="Autophagy-related protein 27" evidence="20">
        <location>
            <begin position="25"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="21">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="TBU61600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="295" mass="31852" checksum="CC90F6DE3A1A17B4" modified="2019-07-31" version="1">MAVLCRYTISRVLFLTLLSTLVAAQDDQKPFDCHVTIGEDAYDLTGLKGEHTVTRESNMPPSTIHDAVTFNLCEDLAKSSAPEEDQCPPGTRACLVRTSRKNGHDDRVISVIPVANSSASAVSYDPISSPKGLQLTFAGASYPSVVGSEPSPQHFHLNLLCGSSVSDVNFVSYNGTDLYLDWEAPAGCLIKTPPGEDTKEPTDGGDDGSGSGEKKEEAVGSGLGYFFLLFFLAFVAYFALGAYYNYSTYGATGADLIPHRDFWREVPYMLRDLVSHICSAVRPRHSASRGGYIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3S6</accession>
    <name>A0A4Q9Q3S6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucoamylase</fullName>
            <ecNumber evidence="9">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_845075</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3S6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3S6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05808">
        <property type="entry name" value="CBM20_alpha_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020905095" description="Glucoamylase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="CBM20" evidence="14">
        <location>
            <begin position="475"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU61937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="574" mass="60876" checksum="FF856A08E04A95AC" modified="2019-07-31" version="1">MRFSLLTSLAALAVGAYAQSSSVDAYVASESPAAKAGLLANIGPSGSKASGAKAGVVIASPSTSNPNYLYTWVRDSSLVFKTIIDQFTTGEDTSLQGLIDQFTTAESILQQTSNPSGSVSTGGLGEPKFNIDETAFTGSWGRPQRDGPALRSTAIITYANWLLANGNGTSYVQNTLWPIIKLDLDYVQNNWNSSTFDLWEEINSSSFFTTAVQHRALRQGAAFANAVGQSSVADGYTTQADNLLCFLQSYWNPSAGYVTSNTGGGRSGKDSNSVLASIHTFDVDAGCDAATFQPCSDKALSNLKVYVDSFRSVYSINIGIASNAAVAVGRYPEDVYFNGNPWYLSVFAVAEQLYDALITWDKQGSLQVTSTSLAFFQQFDSSVTTGTYGSSSSTYSTLTASIKNFAEGFLAINAKYTPANGGLSEQFDKSTGSPLSAADLTWSYASALTAFAARSGKTYASWGASGLTVPSQCNGNAGPTVSVTFNVDATTVFGENIYITGSVPALQDWSPDTALLLSSANYPTWSITVTLPASTVIEYKYIRKNNGQVTWESDPNNSITTPASGAVTQNDSWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3U2</accession>
    <name>A0A4Q9Q3U2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1036938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3U2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3U2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015355">
        <property type="term" value="F:secondary active monocarboxylate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035879">
        <property type="term" value="P:plasma membrane lactate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000340">
        <property type="entry name" value="MFS transporter, SHS family, lactate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="496" mass="53339" checksum="F77B06F53FB9DAA5" modified="2019-07-31" version="1">MAPYFLRSLIPRREARTEGRPLLQALATVTWVQWGHFWAGWLAWTCDAIDFFSVSLSVTNLQHQFGKNTHTISTAITLTLLFRSVGAVVFGILSDRYGRKWPLIGNLLLVSVLELGSGFVQTFPAFLAVRSLFGVAMGGIWGLAASTALENLPVEVRGLASGVLQQGYAVGYLLAAVINLTLVPETSTSWRSLFWCASGISAFSAFVRLLLPESAVFLRAKEAARARGGGSTKSKTRIFIHETGEMLKRHWLLCIYAVLLMTGFNFLSHGSQDLYPTYLTQAKLFTQHDATVATIIGNCGAIAGGAIAGWVSQYIGRRLTIIIFVLLIGAFIPLWILPTGFGALAAGAFCIQFGVQGAWGVIPIQLAEISPPAFRATFPGVAYQLGNMVSSASAQIEATGASNLHTTITGKDGKPTVVSDYATVQGILIGVVAAFVLVVTIVGPENFGSHFEKHKAAFEEGGGRDEVVEDEDESAKPSRPTSVQIVDEKRSTPEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3U5</accession>
    <name>A0A4Q9Q3U5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_946713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3U5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3U5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="351"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="55754" checksum="5578282D30961E3D" modified="2019-07-31" version="1">MDHLQIISYTSLVEDLPLLVGLFISVLVYAAYRIWARHEAARARSSSLPAELPSEKARYASAKDRAPGEWLPVKFDYPRVEPSPAHFSALKPIPYRPFKWGDYHVTMGIKSMPWDEWIELDDEFAQTHRVCEYRIRTLGDRLVRVHPAQPGVVESGHAAAEECMYELAEYLSRRHPDVYRVARHPVSQREDENGWYGEGRIRTITIVPFQETYDLEKEEPLKVARSLIQEDFTIMVEGSDGRYYLQAGAVVIAGSWRLSDKIGMPLEDIHISGNVPQYKSKLQMSMDRFFRRMPLDRPVVRNNYSFQLVAEPSMRRPPPAPGSLLDVDPDELAWAVTMNGDEENAEYERARHISDQCGDSQPESGSRETQAQAQTHEETGSMFKLATVGCAVTPATLRLRTERQTLRRLPRTGAIVFTIRVYQTRLDELASEPGVPGRAASAIRSWPEDVARYKARGAYEGILPYLDQCHAEQVAKGIVGEEDRKSDYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q587</accession>
    <name>A0A4Q9Q587_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="6" type="ORF">BD310DRAFT_55686</name>
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        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q587"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="179"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU62532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="589" mass="66703" checksum="1EADE4436D2F62E7" modified="2019-07-31" version="1">MAPMPFPSTRAVPRRKSSEYPDLDEDFGNPAATAEVEEELDVEVREEEPAFLAGQTKKTLELSPVKIVKAPDGSLNRAALAGAALAKERRELRQQEANEQADSEARDFSAPWLDPMAKDSDRVFAQDLRRELRGQKAGEQPKWKEATFNKATTFGEITSLSIQEQRKSLPIYKLRDPLLKAIREHPVLIVVGDTGSGKTTQMTQYLAEEGFADKGRIGCTQPRRVAAMSVAKRVAEEVGCRLGQEVGYTIRFEDCTSPETRIKYMTDGMLQRESLIDPDLSQYSVIMLDEAHERTIATDVLFGLLKKAIKRRPDLKLIVTSATLDLSALDDEGLLTRLGRKMADFPMDPALAKTLIASVELGCSEEILSIVAMLSVQSVFYRPKEKQGQADSKKAKFHQPEGDHLTLLTVYNGWKASNFSNPWCYENFIQARSMRRAQDVRKQLLGIMDRYKHDIISAGKDYNRVRKAICSGYFRNAAKKDPQEGYKTLVEGTPVYIHPSSALFNRNPEWCIYHELILTTREYCHNVTAIEPKWLVEVAPQFFKVADANKISKRKRQEKIEPLFNKYEKPDEWRLSKVKRSARSSQTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5E6</accession>
    <name>A0A4Q9Q5E6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5E6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9823" checksum="BBF2434B16E3EB5E" modified="2019-07-31" version="1">MYNTCTHRRMEIHMGQGKDLVLPRAAHGYARILSRYPGQKGLLLGPHRRMGGSQSLSSLSWTSVLLCTCASSLPSSSGRLVPASYSIQAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5X4</accession>
    <name>A0A4Q9Q5X4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1036264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5X4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5X4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10207">
        <property type="entry name" value="ASKHA_NBD_Arp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="454"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="548"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="454"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="616" mass="65631" checksum="6B58F3532B7E327F" modified="2019-07-31" version="1">MSAVPNTPRRANAQESFTPAATPQTSRVASSHIVQSSPHYQTTRRHSLYGTEDRIILDPGSCIWKVGFSGEGKPRDVFYAGGDSGESLWTLNRASKPAEREEEDRILEAKLQACLRSVFHNSLLTDPKSRKVILVEHPLLPLHIKEIMARILFNNLQVPSISFASSHLLALLAAGRVTGLVLDCGHLESTVLPIFSFRPLYPHLRTTPLAGARLSNHIKALLLMFGTYIPPATSLSATMNIPAASRSIRVPQDVLTEKVIDEIKTRICFVGDPIDTDGSGAAQHAMSPGPSEADLPPSDPALSESEFSRVSADVSIDSSNFAPSSGYSVVSHSQLPGMDHAPGESRVQALATMYGRHSTATDIHLRVDPPPAQQTGTGRGTLIVPGWIRERAAEVLFEGGDVDESSVAEVILDTLLKVPVDLRKTLASTILVVGGTPMLPGFIPRLQAELTRAVSRTSNSSSSSAAPSRAGRPRPRPAAYDKYAALRPLLPYFAILNNPAPPPPGNATAAANAGKAPAFTPSMMAWVGGSLAGALKTGGVEVQREKWDEAEAQPDSDDDVPMAHDSSPARSARSSPAKSILPDWTRTPLPTGAPPAPRPPAAAAYIPSAQEQMVMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q762</accession>
    <name>A0A4Q9Q762_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_627565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q762"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="18122" checksum="D99C5288F9DD6387" modified="2019-07-31" version="1">MLFFRSCLRYPLGYPSISMHTFRVHHTLSPCLVVNTSFPPPQVLTVNHRICTRRTCMQSAVSLSVTYMSIPTYILHITTAHNACLVYSSDLRSPIPSFTLYPFYLTFTPPCCPYVYLRTSHHRHFIGRGMLTAGRSRRLRPACASPKLVYSYSYQYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q775</accession>
    <name>A0A4Q9Q775_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918253</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q775"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="55" mass="6393" checksum="1EF5281C96B68FB5" modified="2019-07-31" version="1">MGEEVRQDMSRCGVPRRRSAGVLRFTIIVNGTTVKVWGDWWIYVEFCGPKASQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7M7</accession>
    <name>A0A4Q9Q7M7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartic peptidase A1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1027490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7M7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="416" mass="43767" checksum="66E49CDC707C025E" modified="2019-07-31" version="1">MSRGFFSFLLFALTFVVATNATSVVQVRDSLVRVPMVKRFNLTGSGTLLARDQARVKNLRARANARLSGTPLSLDAVISVPADNQRIDYAIDVQVGTPPTTYSLLVDTGSSNTWVGAGQSFEQTSTTDETGDDVSVIYGSGCFSGAEYTDTVSLGSGLTIPGQSIGVATSAEGFDDIDGILGIGPVDLTIGTLHPNTNTTIPTVTDNLFAQGTITSDLVAVSFEPTASDPIQNGELTFGGTDSSKFIGDIEYVPITTTFPSSDYFGIDQSIRYGTSTSILSTTTGIVDTGTTLILIADDAFSEYQSATGAVDDDETGLLRLTQAQFAKLQSLFFTIGGVTFELTPNAQIVPRALNSAIGGNADSVYLIVHSLGTPSGQGLDFINGQAFLERFYTVFDTGNNRVGIANTPFTNATTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q902</accession>
    <name>A0A4Q9Q902_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Golgi-body localization protein domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_867893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q902"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3051"/>
            <end position="3074"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3173"/>
            <end position="3198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="3210"/>
            <end position="3228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1920"/>
            <end position="1950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2518"/>
            <end position="2552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2613"/>
            <end position="2660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2761"/>
            <end position="2811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2867"/>
            <end position="2911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3005"/>
            <end position="3028"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3250"/>
            <end position="3296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3309"/>
            <end position="3334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1920"/>
            <end position="1949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2613"/>
            <end position="2629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2647"/>
            <end position="2660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3250"/>
            <end position="3261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3283"/>
            <end position="3296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="3350" mass="374913" checksum="99AD7E501BFF4FC1" modified="2019-07-31" version="1">MQSYSGTDFVLHALLLRSLDDLSLWATLLVWAVRILTVSLLLRTYIGPAVVSLVSTRLRVRSISLRSIRGVYFKAGHGTWRVERIGISYHRPSSGYATRFSFQVQGLSLELDSVSTIRSSIRHKVRKPRPTPSRLARRLWMIVCALLSSLYNYVEPHVRPTIRTFVVTTLRLAISALPTLTNGLDFELEHATVSHSSIAGVRWSVGHAKLHSAVSLAYLPSVVSVNSTKVPTGHRRFASVADWNARLKGSFRRTWDRAWGATQVSASITLQVNAISGHADKSSELFAGSHRGHYFLDVPSVQWSLSGRLNPQQGVQPRSVEMSLDLGKINIQLDVVQKLLKTMKQRREAQEGGGGDVIRGTGMNEASSAPLSATSQPSTGNRAAWRSPLSPSSPLMEALSASMRWRRAAKQSRDLKTRSRAGGKPMMYIVYIKSVEVNIPQLTASMQPQAANGAGGAVLYGTIQQINLRAGLSHPESNDMHKEWLGIKTVTSAEPTADAYSVVLEAKKLTLDRNGIGELMEHLRMTTLDSFKWHSLLVQWPSPWVTAGPALLAGDPNAHLLVSNLSLATVEVTERLDILEGLIGKERSIEKTVHGQSLLPPMLSPMPRVSFGVHVGEVSLRLISPTSESDQDPFVLEARTDGIAASLQSHFTARPDHRYGNVERDFTGLDMEFRYGLTLNPLYTKMWFGPDAHARGAHPQDFPAPSYPSETLLQVDAVHAGGTGHGLGEFADEAAGIVSVDTATIYTHCQIATDAVSVELWQPDVIKSLARILSRLNGNPKPKTPKPSRRVLDELPFGVDVSIAIGRFSVFLTSPDLAPDDTLNISRGIASRMGISITYNALQKHHCSRLSAVFSRDQQRSELSLPKELILHVVREHSTPAAFDTARALIQVSLWDIVLRDAFATPFAADDPYGLGDQSVHHRSLEFLHVDNCDIHAVISGQRPNGVPLPKSMDDCHVEITIPKVRVKMNLSQVYNALLAAHTVQTLLPSPPRSAAAAPGASSTLRLHLQVRLQQLQLLWRFPLLGKMFLRLSALECDIGPDRNVTVRWDHILTAVNVTARHEGHEQEEWEELMRLPRWKVEVNPGVKPVLIRVKGDSGRLRIPFDFVLADLILDLNLTIKSVKHLVRLVRSGRYEDPPPPPAEDAKQLPDIRIELGRLVVEAADDEHEARMALIWRTGFNAAKVRREREEAFQAKVETITSPKPSSVSTLRSDSDFQFSSKHTVSITDARNRLDQVHTTAWRAAMDQAFSKQTEREEAHWQNPIGSLRIPTALKHDMVTVNSVLPVPPLVRLAFNQLSLAITPPSFPYSAIPDYLHEVGNGLPRDTQYSLLVPMHIHFTVTSLRLAFRSYPLPLLHIPPHSKGHTPALDFDTELVIAEEIGTENSVEWVPCEIVKAHSGMHGAAPISLRIPKTLMPVKTYARPTIRVLTDGTTDFSWGVSYQPATQDLMRVLDTLSHAPRDSSPAIGFWDKLRLILHWRVKVLFRGEVHLHMKGSRDPFQLDGHGAGFAFCWKGSPQLLIGQPNGASELIQVISDSMSIIIPNTKDTYGDGTKKPSTKDDTARPAPIICAKFRSGTCFGVRFVLERTCGPECGNCSGKPFDRQCRMYHFKPHYDVKLEWKDQIPVIKSQNDSYNGFRSDFIHMSISLTSGLRKTAHIQPNNLHLSPTVFEHFWSWWHLFNGALSLPVRQGKLYPRKRPISPKFGQHLSTLKYLVSVPKVFISHVYVDDSQDAWADGVTPYVGVKALINEFHADLHQRDTERTEVTHGGTKTIHHKPFYAIEVVLKGLDLRAMLAVFSDPLKQCTPIEYSPLVSNYRTRNDLPSIPLHSSWVDMDDFAFVKTERTSVPDVHLLPAVSCPRFTYFKQEDSGAPDRKATSASRSKFGAEDTHVCFIGKEPSVSQVQMDLVSERIDRLHEKARQQPDGLHDHASAHSHDNDSHENGDARRAGSDLPRMISLLESYKTQLRNIDKAAQATAARNRNSSYYMPTDLVTPEEWAEFDNVYQMHNPHIIMDNAIRDIMMQYYYCSRSRRGFEYHMAQRAVKFIRDQAQASFAEFQRETDKHSGPSLSAHAAAAKIKTFLTGDSAGDTPVEFAPQTVSKLSPTVDPLYGWAEGVSVRKGHFCLLLKPQIVLRSNDDRESVCVLAAVQGKLKTFAIMDDANVNDPVSGKIMNRNFAWLTGLQTFSPSATNTSGKDYVPLEVLVDLRADNSDFDRLVPQTDATFQYDKFNRLRLRNDTTAVAKSVEHKHAHLQNQTDLIRVHVPRFTVSANDRHFQAISNIVTKLLLFTDAAHKTRAEKLENLLFSYDFTNFTSAADVVAGMQHRLRQALETKVDAEQKLRGLGNPGRVELLKIDAHILLLIEELNLIFDAIKLAQDKASSESDQKSALLLHASSEELSWRMLDQHDQLLAKVAIRVTDYYWLSRHDSSTVNNLAVGDLQAFDGAADAEWTEILSKYDEPSTHPLVKRKLFLLAHWTVLPPVGGITIYEDFELSLHPMRLQIDTRVGRKIMCYVWPSRRDRPQSPTETESFAVPDDDDVDEKRPKGLPAVTYTTSPRSASFDLYPTRKSLDMNRLAPPPALRRLGTSRSFTDLRKERQDSLQVPRIQRMNSSGNLRANSSVNLRTNSTDGWGMTKAASMGTTKSAHQSKDKLRSKETDDAMEMKTRASQKTFVRVKIASLHLLLSIAKEDSFLCRDARIRTRDLEYRNRTWSFEELVEQFIPSGRNWRGWVKVAFQQPLVPVLPVARELITKTKWIAKKDTHLTDRPSRPSTPKLLRAKRPTAAGDLDGPRKSGDKSTAILTDPSFLTSEPEALRDATMQPKREGGVRKRAMSLFRRKHRHGNDSTDTSEASGSITSVSSHIMLNSRQLPHRPSVSSIPEGFVAGPSRRVNGTSSTLHQRSHHSLRHPPDGYFAEGQQAELRVPNNGHGDLEGSQINLALRQIEGDDYDRSDSEDEHHHDDIVEHLDVIDPQVSTVSTLTNAANAIVVPPLSFYSRKPVIVLPRPKRKKKKQNDVEKGTATTEEENLHEDALDEHVHDVLNKRDKFRRIMAGVWSFLKTLFWGCGIVVFLIPLWDVHNDLQQGYWVELCQQVETGLFTVTSIGFIPFRVMDTYRICKIWYYQRKILQLRQKAGLLDLYDPDDLPDPVYDKNYVQVLSDKEQIDLHYRKHLARLALWICICNDLNSFFQCLLSGTMWGLDRFQRPAWTTGTTLPLSFLAGIAAGVLIYWGGRKTRRTQQVEDRLRLALDMETDAKSHREERSGSASLSATEEGVQQPPRALEGAQTSSKVASPAASETNLAPAAVDYAAGGGQTATIPEEAPQARERKPSSASLMFSEEMVVPLAEDIHNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA48</accession>
    <name>A0A4Q9QA48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_397314</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA48"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="151" mass="16758" checksum="928C9B589F33B838" modified="2019-07-31" version="1">MRKQPTMLPANGRESKYVDVIRTERNPGTFIEGVGHVSSDPERNPRSRLRGSIEDHCAHEEHVKSSGPAGRWEHNVVVIGLTCFRGSSATMQGAVRYVLRSITGPRAGLAEEMFHRVHIRAYACGTQLSDRPPTNGVRSRKLSNSDLGLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAB2</accession>
    <name>A0A4Q9QAB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_841737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAB2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="186" mass="21286" checksum="56E22781E1A8A226" modified="2019-07-31" version="1">MPQPEINGRPGVAILFHGCTRTTIFRPLRYPHPHIDENSFATLPPTGYIRTTAPRIRGKQYDYASYTTWQQDWQTDTPLVFGGTHHPRIPSQIERERAATERPQRFALKLAANVGNSRLGRALMEKLIDEAIYYKDVPVAISIMQWGGRPYLSHIEDTKDDTLETRKAVLRAYHALHQKAEIGHDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAQ6</accession>
    <name>A0A4Q9QAQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_913117</name>
        <name evidence="1" type="ORF">BD310DRAFT_920330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAQ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6850" checksum="17867FA6E472CEC2" modified="2019-07-31" version="1" fragment="single">MIMYMRLHLYYGTSCLDQGTGSPGGPMGTQIQTWKYRTHIHTSKHCGFTWVRVWSTNGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAU3</accession>
    <name>A0A4Q9QAU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_840649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAU3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
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            <begin position="249"/>
            <end position="293"/>
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            <end position="344"/>
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        <location>
            <begin position="350"/>
            <end position="401"/>
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            <begin position="400"/>
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        <location>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <sequence length="676" mass="74231" checksum="CFB80F0F05180E38" modified="2019-07-31" version="1">MHPSTLRDPRVLVQPAVQANKEHQYALKVYTERLEAELEHLDKLLAATEISDDEDEGFLTVNSGGDVYIPGAVRPRGLIPPSLLTDEDSPFYDVAARRQRYENFTVSHPMNARELDALAEAVRSENYRLHALEAQARGLSSFLAASEPPPDFSMNKQGIDWERVAQKVSFASTTVQRTARECEIRWLGERHPQFNNAQWPQSEITKVRELVGDARQGEIDWVKIAEKLGTGRTPVDCMRHAIPRRTHTWTPDADQRLLEAVDAYGTDSWALVARAVSEDATAAQCQGRYLRTLDPTLRRGPWAPDEDEQLRRAVAAFGHAWIDVAAFVEGRNNEQCRERYQEYLNPTVTKGKWTEDQDSALLKVVEQVGEGKWKEVSRVLNIGRTDNMCRMRYTLLVKRKKAGTASPGPSGAASAAPSRRSTPADKGTPEILILHPDTYHSQSSAATPAPAPASASVPAPAPKAKPKPKPRARRKQPTALAEDIGERASESSAANVPAAGQPERQATEVPQQQAQPELSVEGEDAQPSKRRRTVPPSPPPAVQWTAASTEQEGAQKDATLEDTSGSTQDAQPNEIAESETESTPTTPGRGRGRGEGRGRGRGRGRGRGKSPGRKSTLRRSRVKDNIATPPRSSGHGTSTIAPSEERSSVSTPTRRQPPRAVNKASRRDSQLEEADT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB18</accession>
    <name>A0A4Q9QB18_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="9">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_1034546</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="9"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QB18"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="term" value="F:3'-5' DNA helicase activity"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="RHEA"/>
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        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
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    </dbReference>
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        <property type="term" value="P:interstrand cross-link repair"/>
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        <property type="entry name" value="DEXDc_FANCM"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="FANCM_ID"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SF2_C_FANCM_Hef"/>
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        <property type="entry name" value="Fanconi anemia, complementation group M"/>
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    </dbReference>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
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        <property type="entry name" value="FANCM/Mph1-like_ID"/>
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        <property type="entry name" value="FANCM_DEXDc"/>
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        <property type="entry name" value="Helicase_ATP-bd"/>
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        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="entry name" value="FANCONI ANEMIA GROUP M FANCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14025:SF20">
        <property type="entry name" value="FANCONI ANEMIA GROUP M PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="278"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="611"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="116"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="195"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="801"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="854"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1341"/>
            <end position="1387"/>
        </location>
    </feature>
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        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
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        <location>
            <begin position="870"/>
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        </location>
    </feature>
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        <location>
            <begin position="918"/>
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        </location>
    </feature>
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        <location>
            <begin position="930"/>
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        </location>
    </feature>
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        <location>
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        <location>
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    </feature>
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        <location>
            <begin position="1190"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00004123"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00009889"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU367027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
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            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
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            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU64862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1408" mass="153965" checksum="7495C3AF9E14EBF0" modified="2019-07-31" version="1">MDSDDYFDDDIDASFLNAVDAIEAAHTATAAAAARPPAPQAAHNASFKPAFAPKSAPPRNNSLKPVPASLTRPPRKTTPPDVIEREGSSSDYGFDDMPMDEAALASIDRAAEIGYARHGAPPSNQPIAGPSRVGGLARVPSKTTQMNLFGEVAREGEPPKAAAPSHRTFERTRSKLRQMPLPGQAKRTKLWDRTAYAKSGWRKPKPDPEKEKGKGRGMDDEDDEEPIEFEQFPAPAISVGPVCRKLCTPTIKLVPDRLAAKSWIYPLNKPKREYQYNIVKNCLLENTLVALPTGLGKTFIAGVVMLNFYNWFPQGKVIFVAPTKPLVAQQIDACHQTCGIPGSAAAEMTGSVPMAKRANAWKTQRVFYATPQTFLNDLIRGIVDPLDIVLIVIDEAHRGTGDYAYAQVVRYMMQHNPHHRILALTATPGGKPEVVQEIVDALHISHIEIRSETDPDLKKYLHTKHEQEHFVQMTEDICVLRDALSAMMVPLIKKIQGAGFLKNGNTQPTMLHPYRCQSTLGEMTKARAPQYAIGAVAQLGPLARAMGYLMEMSINMCYGFLKGIAEGADDSSGKKAIRKSDAFKSLMAKFEEQAARGLSMHPKMDVLRTLLIDHFAQRLPDDTDGGARAGESRAMVFVSFRECVEEIVELLNKESPIIRAKPFIGQGTDKQGKKGYAQKEQLEVIEQFKAGKYNVLVSTSIGEEGLDIGEVDLIVCYDAQKTPIRMLQRIGRTGRKASGTVHILLAQGREEQNWQKAQSNYANVQHFIVRASDLEVYGDVDRLLPPDIEPECREMEMEIEPYIREERPSRKGSNATGSPKGPKRKRNDDPMRNIPAAAAKGFVSVAELLTKGSAARKKATQKLSKVDWEHADEDDSDDEDIEAGLFAQPRRVKSTSAADSSKGKGKKVLARSATAAGPRKKASGPKKKGAQQTTLTQLDLVSSDDTDDEAIERGLPLPSKPATTARKPKARQSSTPPVFGSARLILERSSSPEIPLKDVVGIIDLPDPDQTRSGAAMLDSSPVQRSKRSCLKILDSSHERPLKQGLLSRSTSDQSQESRRSLPPGSSNPPECSTSPTSCSASAEKQAPGADSMAWLIEDDEDPDIPELSAAPGPSRPMAPAGSFSDEPLFLSSPVREMSPLRLPSDDYEVEFVDEPHPKPSSRPSASNSISSPRRSITSRKSDMGPPALPSNLVPVSPSLSDDLPPEPSFAVRPPGKQARRRVAGDVLDLESSPLAPPPASQRRLKHERPKSPTPPPAQPLRKKKRKFKDTAEAQRHNPWIDVEATHSGDEMSVGSSQPDLDYIVPDSDDHAFLEEPAETQVSPSYDQSAVYRRSLMTQAPGGGGPVFANRPARRGQAALRLDRGGTSRYRRALTPPLRDDEDDYERDSFVVDDDAEIAYTQAPSSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC06</accession>
    <name>A0A4Q9QC06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP synthase subunit beta</fullName>
            <ecNumber evidence="14">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_1033656</name>
        <name evidence="16" type="ORF">BD311DRAFT_707355</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="14"/>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC06"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC06"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.170:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000026">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 14" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="209"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU35417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU65257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="541" mass="57878" checksum="76175A6DC84E3AE3" modified="2019-07-31" version="1">MLTSRGVHRLSRRALQSAKRTNAFFSTAVAAPAIARAASAPSSSQRALPRYAPASQSARSYATEATGTTGHVKTVIGAVVDVQFETENLPPILNALEVVDFHGGRLVLEVAAHLGENSVRTIAMDGTEGLVRGQKVVDTGAPIRIPVGTATLGRIMNVIGEPIDERGPIKGVKLSPIHADPPAFVDQSTTAEVLETGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIQELINNVAKAHGGFSIFCGVGERTREGNDLYHEMIETGVINLEGDSKVALVFGQMNEPPGARARVALTGLTIAEYFRDEEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLSTDMGGMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRSIAELGIYPAVDPLDSKSRMLDPRIVGQEHYEVATAVQKILQDYKSLQDIIAILGMDELSEEDKLTVERARKIQRFMSQPFAVAQVFTGFEGRLVPLKDTVRSFKEILSGAHDNLPESAFYMVGTIEDVKAKAEQLAKEIGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC86</accession>
    <name>A0A4Q9QC86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c oxidase subunit IV-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_911242</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase IV family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC86"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC86"/>
    <dbReference type="OMA" id="WYISYGA"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00922">
        <property type="entry name" value="Cyt_c_Oxidase_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.442.10:FF:000002">
        <property type="entry name" value="Cytochrome c oxidase subunit V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.442.10">
        <property type="entry name" value="Cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004203">
        <property type="entry name" value="Cyt_c_oxidase_su4_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036639">
        <property type="entry name" value="Cyt_c_oxidase_su4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707:SF10">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10707">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02936">
        <property type="entry name" value="COX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81406">
        <property type="entry name" value="Mitochondrial cytochrome c oxidase subunit IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="174" mass="18665" checksum="746FA77C97F59675" modified="2019-07-31" version="1">MQALRLARPRLPLRPASRAFAAAASSVHGGAPAASSSASPVIPLSNVEAMWERLSADEQLVIHQQLEELQKKDWKSLSIDEKKAAYYVAFGPHGPRAPTNPPGTVPKVILGVTGLVVTATVLFYSIRATAPPPPKTLSKEWEEASNERALEQKINPIHGISSEGYSGPGFVTHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCA6</accession>
    <name>A0A4Q9QCA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_911009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCA6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCA6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="44648" checksum="60B3D9548EB67C4F" modified="2019-07-31" version="1">MPNMPSCIRLPPELCDQTIDHLWDDLESLRACSLTCKDWLPGSRYHLFRNVRLRHSDDVTRFRALLTSSPGIAPCVRKLSLSADYDRSAEDGAAREDDAWVNSAAELFPMLQHVTTLALARVRWHALSGDTRAAFAGLFKSVRQLFLFEVSFDASRDVVAFLSAFPALQELYFQAVSWANDSPSPFDDPRPDAMLDTSRMQLSYLFLDPKSSPTLVTEWLLQRPDEQRLQTIQLCWRELDNTKSVGDLLQASGSSLESLQVEFPAGLSADAAIQNHLSLAHNTGLRALHFGGLDVRASGGFVSHRLFPWVTVMLSQVRSRHLQEVSFALEIASVDDLLALDWARIDRDLSREEFHGLMVMFYVSCEREGVEKEVRREISERLGGFQKRGTLCISCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCM2</accession>
    <name>A0A4Q9QCM2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_804270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCM2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCM2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF51">
        <property type="entry name" value="SERINE-ARGININE PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="95"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="36940" checksum="F362951A958BFFBF" modified="2019-07-31" version="1">MARRLYLGKLPPDARSEDVSKFFDGYGRIVDCRVMTGFGFVEFESSRDAEDALQHFNGKSFMGASIVVEFAKETRPRRDPYEAERASRARRPPGFRLIVSGISRDTSWQDLKDFGREAGSVSYADIDRDAPGEGILEYLSREDAERAVKELDGRDLRGQPVRVALDRERGGADDYRRDDRRDDRHARDDRYPRDDRYREDRYRDDRHRDDRHRDDRGYRRERSRSPPRRTEVDDRRPVRSPPPKRDDDRRPAGYDDRRGGYDDRRGPDPYYDRRRDDVDRRRDDRRRDEREDRVDDRPPRHANGDNTWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCX9</accession>
    <name>A0A4Q9QCX9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_866623</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCX9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCX9"/>
    <dbReference type="OMA" id="TNQRMER"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="309"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="372" mass="41920" checksum="1C59C8EF0C5CB609" modified="2019-07-31" version="1">MAFWRKSEKTLIPPVQSEESKRNELLGSRGNSTSSRPPSNFSRSTSSTYVASRDGDPYNSTPSGTPPPQNNYGGDRYVRQNAVGDPYSRGRGDINQDRNELFSGYKPPQQGSGRFFNDGPTGGAPRRGTPPPGEENEEDVEGIKQDMRFLKQDSVNSTRNALRLAREAEETARNTVSKLGSQSEKLADTERHLDVSKGYSLRAADKTDELKQLNRSIFRPVITFNKDAKRAAQEAKIQARYDEERANREEAMRDIRDTQDRLGRAATYGVRGDDEGIAGGSGRFRTATQLQQRKEQRKRYQFEADEDDDALEDELDDNLDEIMDVTKRLKALGTAMGSELDTQNDRITRITQKTDGLDQHLFTNTQRLNRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD71</accession>
    <name>A0A4Q9QD71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mnn4-regulates the mannosylphosphorylation</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_901862</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD71"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD71"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021836">
        <property type="entry name" value="DUF3429"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15887:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 69"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11911">
        <property type="entry name" value="DUF3429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="35383" checksum="7C397C748176BADF" modified="2019-07-31" version="1">MALRRPLSTSASPLLKQATNSRLSPHLLRNQLIVRGAASSVSGRPGSQTLGHAAENIREEVGQSAADLAKSIAGGNVFADNVEPTQQTFLGITNAVAHAVPTPYVVFGLAGGIPYIGASGATVYLAYQAGLATQGLVSNIDPGVAITVLHQALSLQTTYGAVLLSFLGAVHWGFEFSGYGGHKHYSRLFLGAAPVVYGWSTLALDPVGALIAQWIGFTAMWWADLRVTGLGWAPKWYSQYRFYLSILVGTCIIGSLAATSYWGPVGGHGLVSHDLNMIRAERKALATEKEGSVAGDIEATPASEDADRYVVVKKHEDSEGEQGKPGQQKQQEPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDU1</accession>
    <name>A0A4Q9QDU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_837244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDU1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="325" mass="36313" checksum="0F519F07A6EE4A3A" modified="2019-07-31" version="1">MSSTRIPLLFGTMTIGEPGKNGVRTSDLKEAQEIIDVFFEHGHKELDTARVYAEGTTESREQYLAKLDLKDATIDTKVYPTQPGVHSPAKLRETFQISLKTLAPLKVRVLYLHAPDRSVPFEDTVREVNELYKEGLFEIFGLSNYAAWEVAEIVSICKANGWVQPRIYQAMYNAVTREIEAELVPCCRKFGLRLVIYNPLAGGFFAGKIAAPDAEAPAGGRFDPGSNMGTMYRARYLKSGYFDALEYLKPIAEKYQLRLTEIALRWVQHHSVLTPQDGIILGASSAAQLRQNLQDSEKGPLPEEVVKALDEARLIVGASAPTYWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEJ6</accession>
    <name>A0A4Q9QEJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CRAL/TRIO domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_805914</name>
        <name evidence="2" type="ORF">BD311DRAFT_670472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143468">
        <property type="protein sequence ID" value="TBU25024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEJ6"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="106"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="39889" checksum="BE028A4B365F81D5" modified="2019-07-31" version="1">MTADTEKIYEASPPPDIPFDPAALPSNLQLTDVQQKLFDDVLKYFDKEDYVLPDVENGTLTEEEKFWLSAECLLRFLRAVKWASAQAAIKRLEGTLKWRREFGVYDVITASHVEPEALTGKMVLWGYDTDNRPALYLRPSRQNTEESIRQVHFVVWALERLTELMGPGVETLALMVNFADRAKNPSLTQSRLVLNILQTHYPERLGRALVANVPFLVNAFFKFITPFIDPLTRPKLRFNPDCTGEGLFAPGQLLAEWEGGQADFEYVHERYWEPLVRLCAERREKMWVAWRELGAKVGVREWDVKCKAELEAKAKEGEEGTKATVGTPITDVAAEENEAETQNGEAAAAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEK4</accession>
    <name>A0A4Q9QEK4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_803904</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEK4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEK4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU65790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="318" mass="34379" checksum="9B039FC6BC5DF495" modified="2019-07-31" version="1">MSPVPFPEPALRDPDVEEGIKYWESQPANYDGVLGGFGNGPLPRVDALGSRQFLMHLLPELCAVPSAIRPLNVPAQAAQRRTRALDVAAGVGRVTADVLLHLFSDVVLVEPVAPFVREALRRGRASEAPAPAPAPTPESAGADPDSLELVPWKGIADGRKSVTFVQATLQDFDPTRPGKARVLGRVGRVPPAHEDDLGAGFDVVVCQWCLGALSDADLVAFFRKCRAALRDPARGLVLVKENLCSEEGGPRAVFDESDSTLTRSDLAWKKCFADAGLKVIDERIQRGFPEGLYPVKMYVRPCGLTLLAHFTLGRYALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEQ0</accession>
    <name>A0A4Q9QEQ0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_864578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEQ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="164"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="705" mass="79017" checksum="D23C2248885A9B4D" modified="2019-07-31" version="1">MVYLPPPHLASASRPSYAEAYAKILASHRRSPKTAASSVVILVAPDVDALCASKMLADLFKQDDVMHRIIPVSGHAELERIRDELTTYAELHTLIMFNMGAILDLPSPEWFGDFPTSLTVHVIDSSRPQNLSTVFGGGENGDRIIIWDDGGVEHLEEERKAWETLTYAPEEDSDEDSDFDSEEEEAEEDEDDDQEGYDDGQSSASQPRKRKSLEEGGRRRGKRRRVDEPARLSREERAQHESRLIKYYRSGTWHGQSAAGTMYLLATVLERVDPDLLWLAILGLTHQYATSRISRDEYDKYQAIYHDEVARLNPAPPAALGDDLKAAGADDHSVYASDEFRFMMFRHWTLYDAMYHSSYVASKLGIWKERGRKRLTGLLAKMGFSIPETQQPWQHMAKDLKESLRGKLEELAPEYGLVELSYPSFMRCYGYRSQPLSAGDAVEALSALLDIAGGTRIEVEVEGTRNGGEWFGGGKLWEGGKEGRHHNDERENVPPDVLANVVKAQVRAQAAGDGKEGGEGEDVDWWVKNFWAAFDALSDINRLREAITLSMALHRAIIRQGSSIIDKQDIKTLRGHRVVILTQGPDLPLFVHPGVLGRLALWLVDALRDRVEATTAAYSRSKRKSLPFVLACLNEKAGTYIVVGVTGAADFDDIRKNEFGLAFLDAKERCNARTRHGTFDTSVLEINKDDLKVFLETLCEGGERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K2T2</accession>
    <name>A0A4V2K2T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_905150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K2T2"/>
    <dbReference type="OMA" id="NANKSAQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="384" mass="43311" checksum="46433E53166611FA" modified="2019-07-31" version="1">MRAPLRKLVIDCDNIISDFWHPAALEEFLPHLVPALEEFEMSDLLITPQEATVHGAVTSASISSMAQYPAVHSLTVRGFAGPPFLEHLQHLFPSVDQKLALGRLDLDIDTLIYADIRNANKSAQKEESPDYLRPWKKLDLVVCDVPMFYVLGLRCPIRHAMLDYGWSHYRGYLTDALRENPVPRLELSIALSYGLGAFDELFPLELVPTLTHLTLCLVYANMGGSGTDADAGFDFRWRDVLLLSSLGRLRALTHLRLVIHTDVCHDPPESEPYSEAFVNDLRGPTFGFQETAQVLANALPSLRYVFLTTRGYLGKHDESTRYFWKAYERRLVSRAWRIADKGGEQRREGLILVELAEAVAETLIDQEELLLSPADEISLHIGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4A9</accession>
    <name>A0A4V2K4A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Concanavalin A-like lectin/glucanase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_934973</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the glycosyl hydrolase 12 (cellulase H) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4A9"/>
    <dbReference type="STRING" id="114155.A0A4V2K4A9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002594">
        <property type="entry name" value="GH12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002">
        <property type="entry name" value="BLR1656 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34002:SF9">
        <property type="entry name" value="XYLOGLUCAN-SPECIFIC ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01670">
        <property type="entry name" value="Glyco_hydro_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043490040" evidence="4">
        <location>
            <begin position="30"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU54835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="360" mass="37702" checksum="483180BA8CA4B83D" modified="2019-07-31" version="1">MLMRVQYPLELIAVLVLFLEGLPIGGASAQTTLQGPNDCTAAGAYTLCQNLWGADTGTGSQTTTLNSAGGSSVSWSTSYTWAGSPNNVKSYPNVYHNTAKGMQLQNIVSAPTSWQWYYQSASSDLAADVSYDIWTGVPQSGDPASSASSYEIMIWLSDRGGVGGIGNVVAQNIQVGGHTWNLKQGPNSNWDVFSFITAEGDITNFNSDLNDFFQYLIDSQGVAKTQYLQAIQTGTEPFTGTADLVISNFSVDVSTVDDSPTSSSSSSTLSSSHSSSTSASAQPSNVSSHGTPSTIATSSASTTSLNTATTSAAPASQQTSEAGSVSNPGVRGKSGPQCRLQLPTSGTVTRRGLFRRLFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K562</accession>
    <name>A0A4V2K562_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_814598</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K562"/>
    <dbReference type="STRING" id="114155.A0A4V2K562"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="282" mass="28634" checksum="AF1C27AA8E3448BF" modified="2019-07-31" version="1">MLMPVDSDGSPSGSSVGSRGATVPVSGSTGGRTGAVAYGSGTTKAVTIPQGQPFAGRTSGGATRDSIYGNSYYGSGYPGVSGLGVASRGFPFVYWPLIWGGGLGYGAAYLHDNHEYGELNNSSRPGGPMAQAAFFSNSTNTTFHIVSDNSTVFSLIGSITMNCTVASNSSTIPSPFNGSATDPLPEQAIQYYRASSVALTLDGYNNTAALAGNETTPPPLPSGIDTNLLNCLNATIGEAVPLFQDSSSSGSTGSVGAAARLSTPTMGLVGLIYVVWCLSSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6X7</accession>
    <name>A0A4V2K6X7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_951719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6X7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="217" mass="24319" checksum="16F38B5AB0AC037C" modified="2019-07-31" version="1">MSTHVTLYQMENIRCVLVFRDEHRSGDWDLFYGSFLTNILCNGIHLSAVREVWISGNHPEAGRQDHITAKFKSTIAALPALETIVFVVTTISCSPPQGPNLTLCPSALDAGFAPRKLKMLRVVYGNAAYRGCIVEALSLKRLLQHVDTGFYGYFETLILQMEPWLVVSTVDLQRLKGHFATVKYRHVERMPMMPVPDFCVEPYAGPGGSSSWLGSLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7T3</accession>
    <name>A0A4V2K7T3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_968204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7T3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000023">
        <property type="entry name" value="Dimethylaniline monooxygenase [N-oxide-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="547" mass="61287" checksum="9C041BDC86A41109" modified="2019-07-31" version="1">MVHLTLLISSLLPLLALGHAYDSEQTVLSSSASGRPAKSIAIVGAGSGGLAILKTIFDLPEDVRRDWEVVLYEQRRNVGGVWLPDPPGALPRYPELPESPTYPLLHTNTPHPTMTYIGFPYPPNTPLFPTWDHVQQYHVAYAEHHNVSQYIHARHRVAAANWIGSAKGGEWEVEVHVQDPERHTDVDEPVRIFKKSFDHLVVANGHNHYPNIPQWDGTDEWLANTPAGTPQREIIHSIYYRRPERYAGRTVVIVGAGASGRDAALQVGKLARVTYQSLRPGNDPTPGAKVVPKPPIAHFNRTSVVFEDGSALHDVDALILGTGYEFRVPFLSPPHSSVLAVDKHTTLNSTTARTLVTNLRYIFPTHRHIFALHPDIPPTALAFIGLPVLVANCPSDIAQSLLVAHAIANASILPPREQLINELVAREDKLRAEGLDPYYVGHRLVAEAESDHEYQDAVVQYLKDVGALPEDGKKFVEPWRRIGRDNSRLLGRAWERVKERGEENKWLEGVRTEDEWADLMSRLTEWQRAYEEEHGVPEFEGQSVWYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7Y7</accession>
    <name>A0A4V2K7Y7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Amidase signature enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_959265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7Y7"/>
    <dbReference type="STRING" id="114155.A0A4V2K7Y7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="101"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="591" mass="62081" checksum="884D75DD71FAD1EF" modified="2019-07-31" version="1">MHMHNVDKKPAAMPSVQRRPDGGRARPAANPPSSSDMFVMRLTVASLFTLFIAFAWVGFGFTKEAARAPATSAALEFPDLYEASITELQDGLQKGLFTSVDLVKAYFARIEEVNLQGPTLRAVIETNPSALEQAAALDLERRTTGARGPLHGIPIILKDNIATLASEGMNTTAGSFALLGSIVPRDAHVAAKLRAAGAILLGKANLSEWANFRGNVPSGFSGRGGQASSPYVPLGDPCGSSSGSGISSAIGLAAGALGSETDGSIVCPSGMNNLVGIKPTVGLTSRDGVVPISEHQDTVGPMTRSVTDAAIILSAIAGRDPRDNFTLAQPPVVPDYTQALRADGLKGQRLGVPRKFLDGLDPVVVGAFNASLETMKGLGATIIDPADFPDFDEFVASNNETVVLNVDFKVDVNRYISELVEVPTGVKNLADLIAFNIAHADEELVPPFWTDQSQFITSENTTVDQAFFDAVAADKDLGATRGIDATLKAFNLDALLLPTDVSSTPAAIAGYPIITVPLGFLPPNTTLSPAEPTRSGGPNQPFGLSFLGTAFSEFQLVSLPFAYEQATHTRLQVLAFPAAIPKTQLADVVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8G0</accession>
    <name>A0A4V2K8G0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_924339</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8G0"/>
    <dbReference type="STRING" id="114155.A0A4V2K8G0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="235"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="706" mass="79887" checksum="6524119834B36B48" modified="2019-07-31" version="1">MWVLDTETGQFVQHNPDAIVYAILSHVWDTHGELSYEDLRTIQQDYRPGGHRATSQTSIWEDPRLSSKVRRACERARKDGFRYIWIDSCCIDKRNSAELSEAINSMYAWYRLAKLCYAFLADVPPSPQSPEDVSRSRWFTRGWTLQELIAPAEVVFLSMDWKSFGTKHSMARVLEGITGIDEAVLKHEQSLDEISVARRMSWASGRETTRVEDEAYSLLGIFDISMPPIYGEGRRAFRRLQEEILKRIPDQSLFAWGNGHSRPVEVSFTQYTSPLDQDMNLSATRNVEYSTWDGKRCRPPRLDGAAESDYLGLDGFSLFASCPRDFLAAGLIRGLSDHGDFLDLLGKPDVPTQEYTPTPYGIRTQFPLLHLSNQSSWHPEDYQWYIVVLACVEDGYGELSLLGRLCISESFGTHNDHIHVLKAAYAHGQDGPRGLFVLPWSGALAGPGFHPHIHVRTVYLPHPDRASPPDSSEHIMRPPDSRGERSIEVLFPSWARDRLQAQGYRVEWQDHDSDLDVPRRATITLSRDDYTIRIVYQYWCNTSSKPLGVTRLIASVYTSHPDAALSESDSRTQAVPTPARAETFHGIVTLQAAVGRKRCEETINVSLADRGVVLRIWLELASAVCYHLRISDEGPPPKPAEPPWVAKWWERAQKYIKRREAEEATGVIAPHPGRIALGGGWEYEPPSPSHDSEEEASADSSYYGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8J5</accession>
    <name>A0A4V2K8J5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_352617</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8J5"/>
    <dbReference type="STRING" id="114155.A0A4V2K8J5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF26">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020720773" evidence="3">
        <location>
            <begin position="16"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="108"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="283"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="400" mass="42733" checksum="B3BE51185D469340" modified="2019-07-31" version="1">MGAFFWVWLAGEVLFAEVLVTPTGVSKGCGIVEYASQEDAQRSIRELSEQLLLGRPVFIREDRENESRFGATPVPGKIGMAMAGQGLNAVPPPRPPSHNYFTHSNPGNQLYVGNLPYQAGWQDLKDLFRSAGNIIRADINIGADGRPKGSGTVIFETAKDAQQAISMYNGFDWYGRTLEVREDRYAGLTGPGSYRGGPRGGLRGAGFRGGLRGGFRGGFRGGYAGGGGPGAGGGGRDFSSQDLYADYSGPDQPGNLRLGAYSDGGAYGGAGGFGAGFEPEPSQQIMVRNLPWSTANEDLVELFETTGQVELAEILYEGTRSKGCGVVQFAQVAEAETAIGERWHCVQSHSCSHVMSPAKFQQYMYGGRPLDVRFNDRWHTFSPGAAKGGQTVPMQADGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8U1</accession>
    <name>A0A4V2K8U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_946748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8U1"/>
    <dbReference type="STRING" id="114155.A0A4V2K8U1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14096">
        <property type="entry name" value="STKc_RCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000425">
        <property type="entry name" value="Putative calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="18"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU61328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="584" mass="65288" checksum="DC03DDF12F686793" modified="2019-07-31" version="1">MPTGTGVVDAFKNFIRHGKTHHSAQKQQDDDPYQHYTTQQPVQQQPRADQSRHQQQREAQAQQHQTQKHASPNYKEQIEQIVQEEREAKNKMPTYTGLENFRLLEKMGDGAFSNVYKAVDLRTGQKVAVKVVRKYELSASQGAGEKHLNREFKKKPRVTERANILKEVQIMRGINHPSIVKLLQFFESPEHYFLVLELMEGGELFHQIVKLTYFSENLARHVIVQVAQGIRYLHEERGVVHRDIKPENLLFDRIPIVPSKIPAPKQFDEDKEDEGEFIPGVGGGGIGKVKIADFGLSKVVWDEQTMTPCGTVGYTAPEIVKDERYSKSVDMWALGCVLYTLLCGFPPFYDESINVLTEKVARGHYTFLSPWWDTISASAKDLITHLLCVDPAQRYTIDEFLAHSWVTAVPAPPDPTPLPSIPRAPLDSPLLADARGGVRSPGLATLKEAFDITYAVHRMEEEGARRRAQKGGANRGFLQNLNESDEDEDAKPLPKQPPAGAGAKVAANRAVVGNAYDGRAGQRDRGRKTGASKPFELDMDHATLLGRRHRRGVDSSVVSGSPLSKEAPGNDQSTEVPMSPMRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K981</accession>
    <name>A0A4V2K981_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K981"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="122" mass="13342" checksum="CF41194B416F6668" modified="2019-07-31" version="1">MGGLPVLDRVAYAFHRELCQAASFARLSAISPPRQDARHPPRQQSSAPRILLPLIVSHPPSLFLHLAISAVLLHTMHSSRPLPPQPPTSSRGQTYRAPRGAGIRRMWKTGRVSGRSPSGHAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWX0</accession>
    <name>A0A4V6MWX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nramp-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_918532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWX0"/>
    <dbReference type="STRING" id="114155.A0A4V6MWX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015086">
        <property type="term" value="F:cadmium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034755">
        <property type="term" value="P:iron ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001046">
        <property type="entry name" value="NRAMP_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037982">
        <property type="entry name" value="Nramp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706:SF101">
        <property type="entry name" value="MANGANESE TRANSPORTER SMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11706">
        <property type="entry name" value="SOLUTE CARRIER PROTEIN FAMILY 11 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01566">
        <property type="entry name" value="Nramp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00447">
        <property type="entry name" value="NATRESASSCMP"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="568"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU62498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="597" mass="64726" checksum="97661D6BD4B67234" modified="2019-07-31" version="1">MQETTSDLELAAREPERQDVTLDNPPAVAPPALLPQQAQKGGCAAWWHHTKKYAWIVVRHTTKHTGVGIVCAVAYFDPGNWGVDLQAGSEYGYKLLFVVLLAGIFAIVFQTQASRLGCVTGMDLASHCRLLLYDRPKHRLLWRWLALYPLYALAEIAIVSTDLAELLGSAIALCLLFPKLPLWAGVLITASDVLFLLALRDPIRGQPVRLFELSIAILVSVVLICMAIIISKARVHWEDAFDGFLPSKTLFQSGALYTSIGIIGATVMPHSLFLGSALATQDRMSIREATSMADALITVDSTDSMVSETTTLSDSRAPSPQSAKHDMRCCFRSFAAAARRHLRLVQIDGHPDEPKSHAERENNPYYFVRAHLYHGIVDMVISLLGLAVVINALILILSSAVFFDGRNGSRTPASLFDAYALLQDELGKGIAIMFALALLASGQSASIIATLAGQIVSEGFIRWKVSPIMRRFLTRCLGLIPALLVAAAAGRPGIDTLLVASQVVLSIVLPFIVFPLLWFTSSKSIMSVKKPLERVASQDTSTQGALSTQDPMSVEAQVAMVDFSNGKVMVVVSYAIWLVIVIANVYAIVGLAMGEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MS31</accession>
    <name>A0A4Q9MS31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_912980</name>
        <name evidence="10" type="ORF">BD311DRAFT_757547</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143417">
        <property type="protein sequence ID" value="TBU28976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MS31"/>
    <dbReference type="STRING" id="114155.A0A4Q9MS31"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04132">
        <property type="entry name" value="Rho4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000983">
        <property type="entry name" value="Rho family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU28976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU66217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23449" checksum="2037A840A8B1B6F7" modified="2019-07-31" version="1">MATPYNPSESSGPPRRPDMKRKLVVVGDGGCGKTCLLIVYAENRFPEAYIPTVFENYVTLVNYDGKLIELALWDTAGQEEYDRLRPLSYPESNVILIVFSVDFPVSLANVQDKWFPEVAHFCEGVPLILVATKTDLRRDEQTRRMLSAQGQVPVTSEQGAMVAREIGAKYIECSAKTGDNVKEVFNLALKESVRGKWGKMVKQRRCVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MSM7</accession>
    <name>A0A4Q9MSM7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small nuclear ribonucleo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_921942</name>
        <name evidence="11" type="ORF">BD311DRAFT_776630</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143404">
        <property type="protein sequence ID" value="TBU30625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MSM7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MSM7"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000073">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000329">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="9">
        <location>
            <begin position="170"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="10">
        <location>
            <begin position="924"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="97"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU30625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1144" mass="128236" checksum="5D5F3679662D3059" modified="2019-07-31" version="1">MSEPRLVDSYTAPKEVLQEFAEMAEEEDIDPFAETAKQRQIAARQSDYHNRRFNRQAHDSADAFKAVVEGEDVEGGYKDAMRLQRLEKEEERVRRAIEEKERQEREEGQQKMDLDKTPPRAEIEEAQKELAAMQGTKRKRRWDIAEPESEKENKEVKGEWSQEALEGAAPKKRRSRWDATPADVAAETPSGKRSRWDQAPAAAPEVPMTPIIMNAPGLMHEDKHNRYLTDEELDAILPSAGYAIVTPPPGYAPLIRPPKLSGPSVTEVGGFQIQESSDAAAAAAAAGLAPELPTEIPGVGNLAFFKPEDAQYFAKILKEEDETELSVDEMKERKIMRLLLKIKNGTPPVRKTALRQITDKARDFGAGPLFDKILPLLMERTLEDQERHLLVKVIDRVLYKLDDLVRPYVHKILVVIEPLLIDEDYYARVEGREIISNLSKAAGLAHMISTMRPDIDHADEYVRNTTARAFSVVASALGIPSLLPFLKAVCRSKKSWQARHTGIRIVQQIAIMMGCAVLPHLRNLVECIAHGLQDEQTKVRTMTALALAALAEASAPYGIESFDNVLKPLWVGIRLHRGKSLAAFLKAIGFILPLMDPEYVSYYIKEVTIILIREFQTSDEEMKKIVLKVVQQCAATEGVTAQYIKQDILPDFFKAFWVRRMALDRRNYRQVVETTVELAQKAGVAEIVGRIVNELKDEAEPYRKMVMETITKVVASLGASDIDERLEVRLVDGIIYAFQEQTTEDQVMLDGFGTVVNALGIRVKPYLTQIVSTILWRLNNKSAKVRQQAADLTTRLAVVIKQCGEDQLLSKLGLVLFEQLGEEYPDTLGSIIAAEGAIANVVGMTQMNPPVKDLLPRMTPILRNRHEKVQEATINLIGRIADRGAEFVPAREWMRICFELLDLLKAHKKGIRRAAVNSFGYIAKSLGPQDVLQVLLTNLRVQERQSRVCSTVAIAIVAETCGPFTCIPAILNEYRTAELNVRTGCLKALSFVFEYVGPQSAYYADSVVTMLEDALTDRDLVHRQTASTIVKHLALGVAGLGCEDSMLHLMNLVWPNCFETSPHVIGAVMEAIEAMRVTLGPGVLLSYVLQGLFHPARKVREVYWRIYNSLYLGAEDALVPFYPDLGELSEGQNVYDRQPLQMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MYA4</accession>
    <name>A0A4Q9MYA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_817948</name>
        <name evidence="2" type="ORF">BD311DRAFT_685904</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MYA4"/>
    <dbReference type="STRING" id="114155.A0A4Q9MYA4"/>
    <dbReference type="OMA" id="WAQARTE"/>
    <dbReference type="OrthoDB" id="3264219at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU32735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26944" checksum="60061AC356CB7F01" modified="2019-07-31" version="1">MTQLFRSMRLYGNIVLLLLSATVLGITAYWASIFLPNVRHDYSIFAIIVPALTILLLLIGLQWSTPRTEAFFLFILGVLWLAMAAWTTDIIGNTQCDSLTSQTIPTNSGTLSERSWCYEMRVVQAFSWMIFCLYVIFLWILISLTTRAKALGRPFAWAEPIIELPWFGQWPGFPEGQYPMNGMYQQPYAYPAGAPMYAGSGQPQMTPGYVIQQHPGHSVVIQPGVGGQPPTITQIPGSVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N024</accession>
    <name>A0A4Q9N024_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_927236</name>
        <name evidence="7" type="ORF">BD311DRAFT_749405</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N024"/>
    <dbReference type="STRING" id="114155.A0A4Q9N024"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="611"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="666"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="760" mass="82410" checksum="74BB9A72D0BB1E18" modified="2019-07-31" version="1">MDGSNRLKDLLQLQLASDSYAVLHLPFVLETLSKEDFLPSSHTLKWIARVNSLIHSKDPAARWSGLCLAFQTATFSRDIMLECAQSWVGAAMPLLVNQPLPTTKAAIRLLRLVFSSATDVTEYQRQLCIPNVPKYASALIALLEKDSNTETALLAIDTLEHIVSLYPSLCRPLHNQLSNVALRSLNGSAPTPMSDELVEACSRLYAVLPLTGGKVNAPSLWRKSLDDTMAFAWGAFLQVRTTYPDRGYGVPHPAPPSDDPIVDVPLALDRLRAATRVIGDLLRTSTSRPISLPVGPLVRLCLALLQSTLEDKGIAHANHVVHALEASVIPTLWGFACEILISMAKAGRHHLTPHLPPLLTSLAYHLEQPQKSTELLHFLRTTSSLLADGSHLHDSLIASRLVRATLPKLAILLSKRSQAGTENEQASGQGRSKKGRRHARGYEGDEVFKVGRRIVCVTAEEGDVLLVSVDLLEILLSRTQVNAPVHSIASRLLLAIYASLPQLPPSILSSDLSLKQRLCAKLKRLCMGLAIGTTSTMSKSVGLVLSISDGTVDEDDDLTVHTTVDLLLHPRAPPLVRSLPHVEMLSLFRAEEGEEEADTRRRVGLHVLDERSDRLPDATGSQTPHEAEWTRLQPSVPQAARSPGAPSAQEPYGTVAMQVDVSPLAPTAGQASRYPPSSAGLERSQPPTSFAHKQSATHRTAQSPLPPPPDPLPFNSTALSLESKPASDLPVTQATAPLMEDDDDDEPMPTIDLASDSESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N355</accession>
    <name>A0A4Q9N355_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_819453</name>
        <name evidence="5" type="ORF">BD311DRAFT_653334</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N355"/>
    <dbReference type="STRING" id="114155.A0A4Q9N355"/>
    <dbReference type="OrthoDB" id="2720823at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="302" mass="34414" checksum="BB9FE6435DE17065" modified="2019-07-31" version="1">MSVTHRARWDLPLDPTMYAPDEEEKTFMKATTGIQDDEELKEHIFAIQAKAFTIYKYPCIRQFNFMRLKIARMPAYPQFLELGRQRKDAIFLDVGCGFGNDTRKAIIDGWPIERVIVADLSPEMWNIGHELFRSTPETFPVPFLQGDILDPAYLAPAPILPTSSTPILEPLPPIGEMKALTELHGKISAVFASAFFHLFEFEAQQQVARKLAGLLSPLPGSMIFGSHTGMAEKERWDEGGTWTDCHSPESWTELWEGIFAEAGARVEVKTRLRPHRGGRTFYGIYPESTKERFYLDWSVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N3G0</accession>
    <name>A0A4Q9N3G0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_919648</name>
        <name evidence="3" type="ORF">BD311DRAFT_746164</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N3G0"/>
    <dbReference type="OrthoDB" id="112668at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU34438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8958" checksum="2B72669B15929336" modified="2019-07-31" version="1">MSTDHWRMQLNNYVQRNGLQNFVSWTQPVPSGPRNAPTWTIAVFFNGTEYGRGSSTRLDSAKEIAAELCLKALWSQRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N8K3</accession>
    <name>A0A4Q9N8K3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1005826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N8K3"/>
    <dbReference type="STRING" id="114155.A0A4Q9N8K3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="436" mass="45808" checksum="B1ECE2824F5272CD" modified="2019-07-31" version="1">MHPKAVVCQDVEVKGDITIGAAGPIVIGSSCIIERATATDGTMCSARSLSSSSSSDITEPISPQPQQCFSGMTFPIAEILANNVFCLLDNHKDDRKRISARAFGNWIKDLPNLLGDPWTYSQHLYCLCAGPSPSIPYSCRHLFGTLSSLGRGPAFEHKHGSPITLSPVPDGETEQGGAMDFLHDHHDQHDAEAEMEGKSDARTSLSSVGPRDPPHFAILGHHANARHSRRSSSTVFCFSWYGIAANRSSIPPSLTSLGSSTGWISKKTSKWKLSFGKNNANATAGATSLLAAEDGPSLPDVPSSGGKQMSVIASNVTNLLISLNAPPAPSAASPHAILPSETATATANSGLGEDDGMRMGSLLRLSVLVVASSRKSERCYSGPNGNTEDQRSEHGISPSSTRSGRPLASSASSMASSNWGSLEGARSATNGFLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N930</accession>
    <name>A0A4Q9N930_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rab-type small GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_891078</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145378">
        <property type="protein sequence ID" value="TBU51150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N930"/>
    <dbReference type="STRING" id="114155.A0A4Q9N930"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU51150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="210" mass="23231" checksum="A817C7275AD2F49F" modified="2019-07-31" version="1">MPPPHYDFLIKLLLIGDSGVGKSCLLLRFCDDAWTPSFITTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWHANIEQHASEGVNKILIGNKSDWTEKRAVTEEQGRELANELGIKFMETSAKVNEGVEEAFFTLARDIKTRLIDSQAESSGAAGGPQGTEGAVKVNQPASQAQGGCCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBA7</accession>
    <name>A0A4Q9NBA7_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_910664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145322">
        <property type="protein sequence ID" value="TBU51430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="101" mass="11677" checksum="79E41D892A7E2C78" modified="2019-07-31" version="1">MYKNVRNYVLLDTPVRPYGMNTTYITRFSEPLTVVMVSHFLIDLHKADKRMTHQTSFLTLDVMSRLETPESILFHELFGRNDTSGASTDDYGMDTMNSYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCS1</accession>
    <name>A0A4Q9NCS1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_935506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="HET"/>
    </dbReference>
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        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
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    </dbReference>
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    </dbReference>
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        <source>
            <dbReference type="EMBL" id="TBU54571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="693" mass="77025" checksum="050E3EA8C9522E8D" modified="2019-07-31" version="1">MGTQISLMICPCCNGHDAIERPPSKICETCWKGLFMAHLGLLQKVHPSRGGDQTSGGFTYRTTWAEVASRASEGCRWCQLVYATKEEEEEPGPESPLRIVVGSQGCLQNCTPKGTQDLSVFIDDTLHFIGYVYTTADDPAAQYIVARNRVLDVGTTKSLALAKQSLDECIYTHNSCPRPLALPPFLPTRLIDCSNVAHPRLIATDGTRGSYAALSYVWGEPQPHSTTVSNLETYLKFIDPEHLPQTILDAIHTTHEIGLDYLWADTLCIIQDSPEDKGRELSRMRLVYRDAHVTIIAASARRVSEGFLQERPAAPITDHSTFLRDITLPFLCPPGKGHSGEHAVGELRVSPIWTYTDPPGQPSVQYNPNVEPVNDRGWCMQEYFMSPRSLVFASHTLQFHCQTAVQNVGSAYHDEERRARLPDVLFLQDEDLQLIADLGGDEWQLREAWHMLVRDYTRRSITVPGDKLVALGGIAEGMHRIFRTQYLAGLWRDTLLADLLWSKRVRSDIPRPREYRAPSWSWAAVDGQVEAGAISVRSGKGLHVAHVVTCDITLKNAEIPYGEVIAGKLTLRSPVVACAWNLKTPNLLYRIDSLPDPAVITSTDDDEELEVAMEAIGIGYIDSDDDEGVKGVWAVPIHWSNNIVAGLIVDREHSQAPAAGGKRFRRIGYFNTHAAAGLVNWLRDVPLVDIEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9ND48</accession>
    <name>A0A4Q9ND48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_834361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145322">
        <property type="protein sequence ID" value="TBU51435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9ND48"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="50" mass="5782" checksum="AF0D20AB76CB5A05" modified="2019-07-31" version="1" fragment="single">RPRHGTLRAKMTRASITLVSGKGAHTIPPAYHRQRSSYRARVSCYNRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDS6</accession>
    <name>A0A4Q9NDS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_769339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145211">
        <property type="protein sequence ID" value="TBU53536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDS6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7440" checksum="D7E82DF89B19DD46" modified="2019-07-31" version="1" fragment="single">MYVPSSPLSLHSPCLTVPCSHATAALAPKPSTSLLGHATPLLHTSVFKTAQYFPLPPANAAIETVKRAEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHC0</accession>
    <name>A0A4Q9NHC0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glutathione-S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_981495</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHC0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHC0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="255" mass="29702" checksum="3A4A695C34F8318C" modified="2019-07-31" version="1">MSMPDDKILPHATGEAAKTVEKHKEPQDLVFYAGWFCPFVQRSWITLEERGIPYEYKEVNPYKKEKHFLDINPKGLVPAIEYKGKALYESLILCEFFEDAFPDHAPHVLPKDPFDRAYVRIWVDHVSKVIVPGFFRLVQAQEPEKRQQALEEYYTALLKLSEQVKGPYFLGEEFTLVDVALAPWAVRDYILAENRGYSRDAVGKGWKEYAHQLETRDSVVRTCSDKEHYAEIYGRYLRDEAQSEQAKATRDGRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKA4</accession>
    <name>A0A4Q9NKA4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_948787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKA4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NKA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="371" mass="38814" checksum="CE543D84EE3DFA92" modified="2019-07-31" version="1">MNGTTTSPAELRHITSATNLASPSRERKLSTRNSQHLRTHRLGSRSPASIPSSPTSVHSSSSAIFERDIEPIASPLSHTSDPHHIPRAKFTEEIERAVPSVLDSAAAVLTSTNPDDDDLDAISIVTPAPIDPGYQSGFTSPISRLSSRSPSPTGNRRSLLFSNSLPGSPPKPPQGTSPIRPTIQTSPSPPGRTSTLPSTVTPTPTSAYFSAASDADSNSNASSPTTATHTEHPLHSLPSQPHQPQQLTSITVPAPFPSHPPSPKNVTKRLSFISYADLLSSTPASAIPLSSLTSSAVVSEPPPHIPSVIGVPQAQYAASSSGSIHGAPTFVLERDAAMGVVDDVGGEWEREGLGKGLEERLEALNAVPSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRH1</accession>
    <name>A0A4Q9NRH1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_197187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRH1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="431" mass="48155" checksum="D5EF9AAF9910DEA5" modified="2019-07-31" version="1">MSYLPSIDDQPTIPLPMEIYEQIIDSVGIDVGARDYVVSVARATLCSCCLTCQAWLPRSRALLYKSITLKAPRPSDLQISFQKLVRTILDSPLIAALVENITLSELSASKSGVASVLPILLIGRLPHLRTFTIHETTLVVSPGFCSSISSFPALETLKLATVMFPNISAFRRLLTALPRLRDLTLDNVFWQTVGAVPETMIQYIGSMPPIRRLSMIGGQVVGPATWAVLELLAPYLEQLIFSDWNQDKLLAPNKEENMLQFPRLVSLTFRAHPRPLARGSSDFLSKAEAQQLRVINLINRMMLKSTSDLPTMSRRLLRNSPLFERVVTQARLPALEAVNMVVEVWDLSGRIVEELEQRMPTIAEECREKLGVLHRRGILRVIGVNLVDDKINASWFWLGPSRSLPSQYSCIWQYGVPLLDAITIVLGSNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRM0</accession>
    <name>A0A4Q9NRM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic compound dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_839743</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRM0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NRM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF7">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASES DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00083">
        <property type="entry name" value="INTRADIOL_DIOXYGENAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="344" mass="38171" checksum="CF2A1DFB6D4E4DAA" modified="2019-07-31" version="1">MASVQQMKNPLLVGRAIRAQLEHEVPKDLPLERDFREDSHYTITDHVQGLHRSLSKDPRTLDLVTSLVSHLHAFARETQLTHAEWTKAVKFLTRAGKESTDYKNEFVLLSDCLGFSALVDEINHPKPSGCTDGCEPGPFYTDDAPVVPSGSSLAKTNTQGESMCFLGTIKNLKGEGIKDATVDVWQADGDGLYDIQYPDREEPNDRGKILANPDGTFSYRGILPTAYPIPSDGPTGDLLKALGRHAHRASHIHFTVKAPGYDDLTSALYPSHSPFLGTDPVFATKKSLICQLTEEHDPKRCADMGFKEGEVQGGRVWVWKYDFVLPTVEQVEELKKERAGKSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NS31</accession>
    <name>A0A4Q9NS31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GCFC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_925572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NS31"/>
    <dbReference type="STRING" id="114155.A0A4Q9NS31"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
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        <property type="entry name" value="Ntr2"/>
    </dbReference>
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        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="219"/>
        </location>
    </feature>
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        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
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        <location>
            <begin position="419"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
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            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU59238.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTB6</accession>
    <name>A0A4Q9NTB6_9APHY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">BD310DRAFT_973862</name>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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            <dbReference type="EMBL" id="TBU63344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="241" mass="26779" checksum="AF506998C0D7964F" modified="2019-07-31" version="1">MKNLTTQSAADVLSSLPTPAIDKTYGALLIATYLGLIVYGLSLYQLYRYFQLYPTDTRLIKTIVLVLVALDTFHILCCVVGCYWHLVTNYFNPSSLDDNHWSIQLLPPTGVVIILICQAFYARRVYLLESRYRWVVSIAAVSMISLLGFCTASTVESFLAPNVVAFRKKNWLFAAMYGSATATDVVLTSSLVLALWRSRTGLKRVNTSLGFLFTVILPGNLIFNSVASLSVKVYVVSMLST</sequence>
</entry>
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    <name>A0A4Q9NTP0_9APHY</name>
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            <fullName evidence="1">Uncharacterized protein</fullName>
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        <name evidence="1" type="ORF">BD310DRAFT_830650</name>
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        <name type="scientific">Dichomitus squalens</name>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="13738" checksum="58E335AF3561BF2E" modified="2019-07-31" version="1">MTASDSNLFVQNGELYILPTLTSDAIGKAAILDGGSFNLSDDCTSNNKTACSVKSNNQTGATIQPVQYARISTINSATIAFGKVEVRAKLPQDNKYGAWPLSGEIDIMESLGNGISYPALGSNFVRSTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW91</accession>
    <name>A0A4Q9NW91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8361" checksum="2736368BEE2FF711" modified="2019-07-31" version="1" fragment="single">MASHASPSQQNYVIHTDDASTKLSNRVRRQCYNCHMTETSTWRRSILTPSEWLCNKCGLRERRQPRVLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NZB2</accession>
    <name>A0A4Q9NZB2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_711049</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145174">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9NZB2"/>
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    </dbReference>
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        <location>
            <begin position="20"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18231" checksum="E9D7E609E3600B5D" modified="2019-07-31" version="1">MATSSKQNSRFSSLKVFKFSSASSKPPPLPPKDPYYLPNPSLRSLGNSLSPDSLPPSQPATPLSAQYATLVRSPSPTPSYAPSRITVSPYSTTSNYPESASSRTRLFKFSSFARRPKTPKTADSGYSAGSDSVPPPEPVDDPSISLPWNFQVSASTSLPHTHPLISFRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P374</accession>
    <name>A0A4Q9P374_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_534341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P374"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16129" checksum="5EB5FF9F660E5592" modified="2019-07-31" version="1">MQYSRHVGKNTGRVSVRHSRLGASCSEDRQRRGKQETVLPPWDNVKNVAIGSIGECLWVADFMAVKTAARSCGDEGGVGDVMWRLIGDDAKSAVAAAGCRDCRGEGQSIGSGLWRLHGEECQSHRRGHLRSHFAMLETGCTVELGCWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P946</accession>
    <name>A0A4Q9P946_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145405">
        <property type="protein sequence ID" value="TBU51084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P946"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7756" checksum="E09C664DCCE2170A" modified="2019-07-31" version="1">MARYQPHFSCPLFSKGSVVSQTSQKNMNRKYVEDESFPRRLTLPSRHCVKGEECHRRARGFEGKLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9B2</accession>
    <name>A0A4Q9P9B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_388230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145374">
        <property type="protein sequence ID" value="TBU51164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9B2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="236" mass="26772" checksum="C2F65F97DA09E17C" modified="2019-07-31" version="1">MSLDYALEDSFNVEVERLLNDPAVSDMALRSQAQEYLQVYDEPSFVEIDVPQWVRRIQSHTRLKIKYTSRRLFDTMYEAATTLRVPLGARYVSAAICACASHAKSAVTCSQDQPKSVSEALGRLASVWLAFVLWPLYIQAVFPVEPSGEDSGDTTPTGRSEDFFRNTVAYPSRRWPVLRDELYQRDRYRCFMSGAVLFRTPEEALSGVYTSDLLVTHVIGAIPLASVRLRHHDDQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBF5</accession>
    <name>A0A4Q9PBF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145342">
        <property type="protein sequence ID" value="TBU51305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBF5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="344" mass="38449" checksum="504695CA33539A04" modified="2019-07-31" version="1">MPGSRPTSPLTYFPRRSPLTRFDFIRDHYSRMMGHASLIREPGLFITAQSTYILPRLPSPWDFSSSVDTYLFERVCFNLGGQIRMGTAYMMFEEGAPPLPPLMGPPAPPANSPPMAPVIQPLEPRDPPPRRPTPMPLFIGGVGISDPEPPLLPRMRPVPTPVETPQLKVQEVQGWTAHAESEEEPSPENQEEAASAEDTPMELEYPSSPEPEPEPELVADEATKEVPSAEEEVEGPQAHYNLRPRPELRKSYFESSILRPRKKRAHTSVKDTFDHPKLVLQVAERIGLKNILLVPAHLWTKDERRFMRLVIKSIRRALSGKVEYGEVVPMYGPGAVVGGGSDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBW2</accession>
    <name>A0A4Q9PBW2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1000125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145270">
        <property type="protein sequence ID" value="TBU52028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBW2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="399" mass="44918" checksum="E7CBB22F4FEF6C60" modified="2019-07-31" version="1">MLNCRRLDESKGRFLFDCGLDDFTGSGTIKAIPHDDVLGRLKLSVKLPAQKYTFTPHGIRTTLPVVPVSSCPPPYILERSSSDAPWSQWYLMILGCEHVDHPGGLLGRVCYIPPSAAGVEYLHCGYMYIIPKPNRGTRFPRLFPLPPATIERCRNVIQIKTVYVSHPERAAARSKNARDEPHETINLMLRKATRDALRAQGYKAELRGPDEGHPTTHWLTLSNDDCTISIEYRHMLEEGWLLRIGADVKMSRRALDTGEDVEADPSSVRWKDSNPWYSSLSTKEVSFTLAGKKLALKLGFDWAALSHYFLRVEVVEVVEVVEMEEATPAVMLEWEADKDHRYFRNQRRRRRARRRGRATETPVAADLGADDNAHPGAPDSDDIASQPQTRSGEGTDGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC71</accession>
    <name>A0A4Q9PC71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_910553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145300">
        <property type="protein sequence ID" value="TBU51625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC71"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="308" mass="35268" checksum="20EE210B59E1EEDE" modified="2019-07-31" version="1">MERAGIAPRTTVGLPVPLSQPVTATKHRYLGRYSDHTTVDYSDDEVVVYNHNRTPEEHRAYNLLEEAYRRATYQEGLLLDRPVAPTPQRQASIELIRQRTLDRIGRTHARAVLHSPVWNEYRLSILSWTPDQASLEFTILDELEHWVLRDDGYDVDDELPSLVNTKQESSAGNPSSSEPLDIFSFLTRIRDNASALYDITNHHPTLTPISEQAHIQVLIEQVQQVINTLHNLQRLVSPPLPPIPAENLRNVQSLLDPDFAEHCRRLHLLLGARELYESHRRIIRNGYESPDASADSDYSATLRNFHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCB8</accession>
    <name>A0A4Q9PCB8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Arabinan endo-1,5-alpha-L-arabinosidase</fullName>
            <ecNumber evidence="4 7">3.2.1.99</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_999073</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Endohydrolysis of (1-&gt;5)-alpha-arabinofuranosidic linkages in (1-&gt;5)-arabinans.</text>
            <dbReference type="EC" id="3.2.1.99"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.99" evidence="4 7"/>
    <dbReference type="EMBL" id="ML145260">
        <property type="protein sequence ID" value="TBU52228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCB8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCB8"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046558">
        <property type="term" value="F:arabinan endo-1,5-alpha-L-arabinosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016840">
        <property type="entry name" value="Glyco_hydro_43_endo_a_Ara-ase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026534">
        <property type="entry name" value="Endo_alpha-L-arabinosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR026534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="325" mass="34442" checksum="D8DF82983CB10B49" modified="2019-07-31" version="1">MKLHLISLLSLNTLALSVPNPLSGSDNVVVRDPAIAFNPGSNKYFVFSTGGGINIFTSSSLNGPWTSSGSVLPNGSKINTSNPNIWAPDVHSVNGQYTLYYSLSTLGSQNSTIGVATSPSMEQGTWDDLGPVIGSKDGDSYNAIDANLIDAEGLKLSFGSYNDGIFQITLSDIHTPAANLPGTHLAGANKEPTEGGFTYKPQSSQYYFQFFSNGFTPLVNTTTPRPAPGGEYKVLVGRSENVSGPFLDKTGNDLTKDASPPTGTLVLGSHDNIYAPGGQSIFFDANSGRDLIVYHYVRNDSYGGPSYLGINFLDFTSGWPVVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCP0</accession>
    <name>A0A4Q9PCP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA-processing protein EFG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">rRNA-processing protein efg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_940418</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145254">
        <property type="protein sequence ID" value="TBU52378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCP0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019310">
        <property type="entry name" value="Efg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050786">
        <property type="entry name" value="EFG1_rRNA-proc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33911:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10153">
        <property type="entry name" value="Efg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU52378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11980" checksum="3D38973B9814900C" modified="2019-07-31" version="1">MSYTHTLTMTLAADVRVATEHRLKSLEADLTKAEQAHIEHTIAARYHKVKLLERQKLLRKTTQVKRQLKGTRKSYPHTNSCSPWLLTSRTQTQREWTHPNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDF4</accession>
    <name>A0A4Q9PDF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_982980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145420">
        <property type="protein sequence ID" value="TBU51062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDF4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDF4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="13124" checksum="A38BC59A56E9ECF1" modified="2019-07-31" version="1">MRMTIEILEHCICPDCLTDVTVNPLWSSNHLVLLTFPRPNIVFGSHSRRTNLWSQEMSKYFPNVGPRILATRPDTDFGHGGSVWCLAYSPDSKWLATGSDDCTIILWDSDGKLVQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEC5</accession>
    <name>A0A4Q9PEC5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_833975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145303">
        <property type="protein sequence ID" value="TBU51597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEC5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PEC5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="550" mass="59824" checksum="67CE8C3B79022D87" modified="2019-07-31" version="1">MLTSIRSLLAVRELELASLTFPSVSELVRLLISVPTLSVLRCINIKFQGKDVQPDLVRCRLDRLPGIISLTIVDTHFSLAQTLIPRYCRSLQSLCLGISNTGKNINQGTALRRHADHNQEASSPADIVTPPTTAQLRALITSATLVRDLTLRIVVHGSTLDLVLNIVSNVLQALRLPLLHNFELEIHCDSSAELALATRTKSVEGICNAIDELLLSHKFGLVHVSIHSRRQRIKLLRPQFERLFPCLHTRGILQVSTHSTTGHAESVGHDLAVDALAVSPDGRFLATGSPDATLVIWAAHPLYSSPRPAQEWLVGNAHHTARALSFSPDSRRLAICAGSVCRTIFWAPHPQQNNNDSGSGRSARWLLHPDAHATLQVWDPAAGARLLVLGRGGYVPTVCMADGAYVMDDNFTSFAHPARDAARLYRQHASAGDEPWRATHGVAHGAVSVSVPARRESRRGGESESAPRRLIAAKCVSPDGQYAAYASGDYSAVRVVRLVDGVCVRELDVHHAEVTLLAFAVLRDDRGMEKEGLVSTARDGAVCFTALQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEZ4</accession>
    <name>A0A4Q9PEZ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_952542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145239">
        <property type="protein sequence ID" value="TBU52715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9236" checksum="7921FB4FFD6E1348" modified="2019-07-31" version="1">MLAEDEYLAFDNDLGEFDPDDYLDSCIEEVDSSPPPLADPPPRTHARSTLYENYTRALSNSMEAGINLLVTASRDAVSTALTCH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF45</accession>
    <name>A0A4Q9PF45_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cohesin loading factor-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_961943</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF45"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="244"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU53584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="802" mass="86917" checksum="2E7ED197052C18F5" modified="2019-07-31" version="1">MPAPPIQSRPRAAVHPVYDSPADSNPRPLKRQRIQSSPCPIPHSDGYSSELEPLTSLPPSSDPALRPKSLSFDPSQDGLRPIPPAILLVSLPSLLAHPPNHKYYVHSLIISLAALRKCLTLPALPPDIECRAWTGLAELGMRVIGGGFSQSEEHGWARGIEQEVEKALSRGSIIAQKHPSLRAYKHQSALLQAQLSHWQHKTKFARNQIRTLLASFMPTDPPHIIYSAQLTLISFLTTPVSAPKPSPGASILSTPGKPRPNSNSSHYRSGSSTPHPSLQDVHAALAAVQELEDRATAQCHKQVALLARVLRTRILVAAGMWADVRDAAQRSEAALGLSYEPMATPKARKPLQPSQSNGVAGAGKANAPPPTEQTFIMFDNTFEAAMAVHLLMLSVVYYTHTGEAAEVSPRLSHLHALLDSEILDKFPDGLIELALPDSSSLVVQVTHPRVLFLLAFLISSTSKRDAVGRKPKRKVFATEGLATWDSEASREISFSLWASMGDVQEVEERLARIKADLLCEVIAVSTMRSEFDTAEENLNTLISHTRTYDIFPLFSARIALYHAHLAHALARPARALRCYQAAAHHSEAGSFVHVAARAGEIALRVGVQRRRAAMGDEWREGLSAADDDWPGDLDDDDDEELEARGMEVVKACRGMGGTLEAIGQVVEACLTPEILKSKQHLKHALELATKAQDNHLRALVLALISAHYLHTAGDHARGMLQTCEQLAAGLGALTKPTGGPGAPAPDGGKDVVGNAPLGLWVGERFLELYKRYGKDARAQKQAGVNARLSRAVQELAERGVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF53</accession>
    <name>A0A4Q9PF53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_981147</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145215">
        <property type="protein sequence ID" value="TBU53418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF53"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF53"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03440">
        <property type="entry name" value="hot_dog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF1">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="4">
        <location>
            <begin position="112"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22070" checksum="B02E6863FEBCC7A8" modified="2019-07-31" version="1">MPSDSLVHREGQSPVKFSGDLTPQQQAGIVKFADVILRGPGDFAKAVGSCLELTEVSISPRPEDGKLHAAVVFEIDVLEGVSLQSLAATAVVVFAIQHLSGLVQDMLNANRHVHGGCSMFMIDICSAIALTALSIAMNKRTHLVSQAINTIFHAPATVGARLKIVNKTVAYGTRTVSARTEIWDITNRRLVVSGIHNQMQPSPPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF92</accession>
    <name>A0A4Q9PF92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="2">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_952066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="2">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="2"/>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF92"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="1 2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043646869" description="AA9 family lytic polysaccharide monooxygenase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="5">
        <location>
            <begin position="21"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="35219" checksum="5A174434CB5CDCFC" modified="2019-07-31" version="1">MVHIAATLISLALLASQAAAHGVVEWFIANGKNYTGDDEFDPKGIPTAIRTVNGNGPVVDVTSPYTACGNQAKVVSVEAPVDAGSIVEIRWSSTWPHNTGAMTAWMAECGGMNCTQFQDLASAQWFKIDEKGIDPTTGDWYMAEIFMDPGKPYNLTIPENLKAGQYLLRHELINLALVANMGGSGAEMYPQCLQLSVQSNGDLVPQSSDYVHFPGAYKATDPGLTFAPGDGQKSQYQPPGGPLAKLVSSSGDASGTDGNAASSTSSMAPSNASSTNVAGNTQQSTAVPSSTGSLSAASDIPTNTCSGDMKNRRKVGREELRGRTLRGRRVRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG40</accession>
    <name>A0A4Q9PG40_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_952931</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145269">
        <property type="protein sequence ID" value="TBU52042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG40"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="49"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="656" mass="75197" checksum="7BB53656869088B1" modified="2019-07-31" version="1">MAYNLRPRKKNKVDGLRPKPDAETKSSPSHPLPMFPPTPLNGPIQTPLIARLPTELLTTIFSLVGPFEKSEPYTCHIRNAETWMGWVPLMLVCRHWRNVGIATPWLWRRISITCNLEALQYRLSRTVDCTIDLFLSRLREENEKAMPLLLPFARSIRSIHIPEYTRSRRRRVRFKTDDLPCLKPLFEVPLPVLEHIDFSKLQRPYDGPLEAPFDLGLSEKLHPGILRFVVPSYIKMPSTPSFWSALRELDVRFEMSEDRRTRLDDFLQVVAGAPYLESLVVLGTLLSLTLSEKDTSPSTVGVPTSLHQQNRLRTIHLDGELTFIAPILQRIDAPALSVLHISASIPPNVDIAESAALLFPPPLRRVLSKCKALYVSRNHSWDFQICSAAVFKPDYIRNQEDAMRVPLYFRVTRYQLSSQLSTAIGVLCDGFCTAPLRTLSFEGFYDAAPVAAWRLLQAAFPDIRKTEGLWVIYHFFLALRELALKGGWPLLSRLEVDFGFQSNYNSLGWHFVLQPLLEAARAWHEQKLRLDEIILQRLHITRWQFGPHRWALLTIAALCDRFILRNFLVDGRLFYDAFHPVWRLLKNAKYQVSTGQQTENTEDPKQDVMDGTEAGSLGVELPEIGGVRQLREKVLTQLLQWFCEYGTPEHGLLSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGU5</accession>
    <name>A0A4Q9PGU5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_889429</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGU5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGU5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00106">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF9">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1 3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Kinesin motor" evidence="7">
        <location>
            <begin position="5"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="4">
        <location>
            <begin position="557"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="608"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="474"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU52461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="687" mass="74998" checksum="1C436D656E822078" modified="2019-07-31" version="1">MSYSRVKIAARLRPAIPGEIHDNAIRVLHSDAGPYIDVDNPRDPSQTFKYPFSSCYDQSSSQDQIFDRDVKPLIEVVFSGVTATVFAYGVTSSGKTHTMQGNTQHPGIIPRAVEEIFRRAASTGLHASIAASYMEIYKDEVYDLLVDRETAAKLPVRENEVGQVFVANLSMLPLDSLQDFHKIFLRANKQRSVSSTNLNSVSSRSHAILTIHVNVIDPVANMTLAGKLNLVDLAGSENNKLTGNDATRMAESAAINKSLSVLGQVVHALNQGASRIPYRNSKLTRILQDALGGSSIGLLICNLAPGTRFRQDTLNTLNFAVRTKNIQNKPVVNQQATTAAALPKPIQLSTSFTLTSFNQPSSAATAGPSRLPGPRPSRVPRPSGFGLDHVGGRSSLPLPPVAEAIKIEEKPPVVPAHLTEEEINARIAKAVEREVARRLEEERERLRREEEERAANLSAGSSASASRNHHVITDGSTNISINTTQEDNSTSSSSSALESLPSGMLTPLLKSKAGASEDELKRRLDELEARFERANKAASTALHLADVLSPISKKKTGRAYVALARSQSQKNNLEVALELYRKAETYVPDNVKLRESRIIEIEWAVKNNRPFNPSPKKRRRAAQSKSKSGRSKRKATPSRDQDGDAEESGKENFSGDEALSAGKRKVEDAEAGTPPRKRRLVKIEELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHW7</accession>
    <name>A0A4Q9PHW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_939800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145242">
        <property type="protein sequence ID" value="TBU52656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHW7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="13535" checksum="26EF4A1B5559A0A8" modified="2019-07-31" version="1">MHGMEYPFQSHLAIYETVTKLDRLDVLSLYYIGNTCLKAISQLQEGTPELESPTAWLICCASEHVPINDAPLRPLPRPPLRLHIHSRLEAFPHKARFVTLGQWRRHPDERLWGTPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIG9</accession>
    <name>A0A4Q9PIG9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_938116</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145215">
        <property type="protein sequence ID" value="TBU53396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIG9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021005318" description="CFEM domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="7">
        <location>
            <begin position="3"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="112" mass="11913" checksum="38BEDAC664DB37C5" modified="2019-07-31" version="1">MKLVLLSFTLICAIASYGALAQFEAADLSDCATQCIENSAPDGGCGSTDVACICNLDPSSFAIGAMKACLQIECDENQAQSLERLHAVECGSPLQQRTEPRRLSRSNTNRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PII5</accession>
    <name>A0A4Q9PII5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_970252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145211">
        <property type="protein sequence ID" value="TBU53556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PII5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PII5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="317"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="405"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="912" mass="96844" checksum="6560A17EDDBBE7F8" modified="2019-07-31" version="1">MSDAFADLWSSTGASKPAEPPRKLGAMAAAAPMSTAQRKPQNDVFSMLAAAGSSSSVNARTPNPSQPTSLGGSASAWPVQKANSTGSNTSGMGGGDVFSGLLSGSLSSGPSSNGANLTIAQRAALAAQEKQARAAHAKPPVHNAHASHAWAGLDALGGSSSITPSSKPATPSHDPLDDLGFGSFSSVPSSSQKSHPPPAEDDDWLGGLAAKPPAAPRSKPKSSTTTSTAQSLLDWDEFESSPPAGPSVTQSISQDDPLGDFDFGNREDGLLGNHSGDEDDILGDLGKPVEQLQVRRSERNTPSPQPPQSGQRSRAVSPPPHLLGQIVEMGFSVQQARIALAATDTGLDVQAAIENLLANGAASSPAPEQQEERRRRAQREPGHERYYGSDEEDDGPRQPQRRPAARPPQQQQQRPARERVEQNGTSPSSDSQRNLQEQADKFIAQASEIGLSMFSRANAFWKEGKERVQRVYEERAAAAGAGSSRQGSADSSRNKARPKWMQDAPDDGHVPEDVKGGSAGRFEDFDDEEASQPSLPQRRQPPPRAKEPPQQPAESPASRFKTASLFADDAPSVYVSPFRRKTPSRAQSGASSLAPSPATAPSRPTPPRAPSPVTLTQRTCVSASASAISASAQQKALGTEKFKLGQYGEAEAFYTAAITALPANHLLLVPLFNNRALTRLKTGDASGAIEDCTAVISLIGEGYHPAREAKVTREDEGAGVDLADGLVKAYRRRAEAYEGKEKWDLAKADWEFVAGSDFAGRARAEAVTGIGRCRRMINTDVDTGASTATAPPRPKPAITKQAPRPKGRVPTPPSEALNRVQAQNRAAEAEDQQKYELKDVVDAKLGAWKAGKENNIRALIASLDTVLWPELGWQKVGIHELVSPSQVKIRYTKAIAKLHPDKVRRILLPDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ91</accession>
    <name>A0A4Q9PJ91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16002" checksum="C39DAD0AD45F155B" modified="2019-07-31" version="1">MTRDEDPVAAGRAQAAPAVPGELRNPLSKLSTAPFAFLAPCSQSIPRHLSTHFAMSTLSYLIKNELAPPHLSPSLHLQRQHTHMLCDTSPGPHSQPQTARSLYTYLPRLASPKGVLFKTANWSKVELLQALADLNSETLQLSASVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJG7</accession>
    <name>A0A4Q9PJG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_828396</name>
        <name evidence="1" type="ORF">BD311DRAFT_665335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143432">
        <property type="protein sequence ID" value="TBU27467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJG7"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU27467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8116" checksum="A7B026182B5C93F2" modified="2019-07-31" version="1">MPRASFTLQNGIDAKNLNAQFATLTPSSPCTSGTNACVGTAFAQCANGQFVTFPCNTGLITPARTFSRDKYRVHDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKF3</accession>
    <name>A0A4Q9PKF3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3'(2'),5'-bisphosphate nucleotidase</fullName>
            <ecNumber evidence="3">3.1.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_935590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>3'-phosphoadenylyl sulfate + H2O = adenosine 5'-phosphosulfate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77639"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:77640"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine 2',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:77643"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:194156"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:77644"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine 3',5'-bisphosphate + H2O = AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.1.3.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:10041"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.7" evidence="3"/>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKF3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKF3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008441">
        <property type="term" value="F:3'(2'),5'-bisphosphate nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01517">
        <property type="entry name" value="PAP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.80:FF:000003">
        <property type="entry name" value="PAP-specific phosphatase HAL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006239">
        <property type="entry name" value="DPNP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051090">
        <property type="entry name" value="Inositol_monoP_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01330">
        <property type="entry name" value="bisphos_HAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200:SF6">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43200">
        <property type="entry name" value="PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU54601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="361" mass="38624" checksum="E0BFA7D372242D89" modified="2019-07-31" version="1">MAANDTAHPYAAETQIAIAAVRRACVLTASVFNKLVKQETLTKDDKSPVTVGDFAAQAVINTILDRTFPDDPIVGEEDATDLRIESGRALRDRIVELANDTLSADLQPGEKEEWGLGPNHGRTVDQLLDAIDRGNYDGGRTGRMWTLDPIDGTKGFLRGEQYAVCLALLVDARVELGVIGCPNLPVAASNPSGPRGCIFVAVRGQGAYQLLLDNPLGGERTKLTIPTFTAESLNFLESVEKAHAKLSFNERVSQILGVTRAPTRIDSQAKYCALARGDGGVYLRMPVGSGYKEKIWDHAAGSILVEEAGGVISDGRGEPLDFSLGRTLGENYGIVACGKDVHPKVIAAVKQAKAEEAQSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLM2</accession>
    <name>A0A4Q9PLM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_711797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLM2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLM2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="425" mass="45886" checksum="E471B24825C962E7" modified="2019-07-31" version="1">MPRVRAAVKPPGGSAQAPAPYPAGASSMAVKRPPPIKRAASESQVLPPTPPRTTHKRKRRSRSRVTDSSSEDEDAHDVPEPESDEEDGRSGKKKDGEVHIGHKKRKTMTLDAIAEELSQARAEEIFWMGEDAAGSSNTAGPSSSKQAHRVVKNRASTRARSRTRSPSSSPPPAPHLLRRGHTGLISPPPSRRAPVVVPRLATPPPEPVKEKGKGFPERDSPNNPFLADDSPGSVPASDVQSSPEPRTPQKHVEKPTLTYVFRGVKMLVSNPHYTSEEAAAETEARAQLPVTHPDFSPSDTAAPKLLFPEARKRDLARRRAHPTVPRPTSPTPTTTRRRAGSSSSDETRDVANGAPGPSTVLEPEVDTEAIAAAMAARVARRMHKGVFADGDAPRTRPSSRSGEPRLPEKDRTDPLKRALGPVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLN4</accession>
    <name>A0A4Q9PLN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_934478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU55120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLN4"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9089" checksum="818D0E2B5AE35BEC" modified="2019-07-31" version="1">MINGSVEQGKSKGKAIRRQVQTRRELCKLLWADRSQGRMVGKGVLGCCRQGDQERQHFEVRSSSYTRRRGSLGSRHAEVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM26</accession>
    <name>A0A4Q9PM26_9APHY</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_695237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145172">
        <property type="protein sequence ID" value="TBU55267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM26"/>
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    </dbReference>
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        <property type="entry name" value="DUF8212"/>
    </dbReference>
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        <property type="entry name" value="HET"/>
    </dbReference>
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        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="22"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="238"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="685"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="706"/>
        </location>
    </feature>
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        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="770"/>
            <end position="779"/>
        </location>
    </feature>
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            <begin position="795"/>
            <end position="804"/>
        </location>
    </feature>
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        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="957"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="967" mass="108469" checksum="95457D2DD190EFD1" modified="2019-07-31" version="1">MRLLNTRTGEFVWVDDPRTVQFAILSHVWVRKGSPNYPEQTYQDLVQLHLVKGKHGESVLPFLSDKVRRFLEIAQNDGFELGWVDSCCIDKTSSSELSESINSMFNWYGYAAVCYAFLHDVTAPGSSDAVVWESEFRDSEYFHRGWTLQELIASSVVIFLSNDWKTIGSKHTLAPLIEEITKIDSAVLTFDKPLEAVPVARRMAWAATRVTTRVEDEAYSMMGIFGVNMQTNYGEGRYAFIRLQEEILKRTPDQTIFAWGRFLSNCAFTFANAERRDISSTPHLPNTPFPKQYLFASSPKDFKDSADLIHLSRDEFARRLGISSEDDAYQVFTPTPYGMQTRVPLVAVSLTDPHSDAPTHLALLACEDPHKGLLALLLHRRGHASQAEYSVGTIVGSIRDLVGSDEPFSASTLWSNYNRATYVSDELLDTLRSSLRMTSVYIPHYPSHNANLLERDTPIHAELRESRLGDRIEIRLSAWSRKLLFMQGYRVSPAAKEDDPLPQRPLTRTLSESSTIGVLNSTGDYVAIKVGRCSCDFGESMGLLGVLVSPRDGRIVNGARLGDQHSINHPVHIRSWCFRSGTASQEFSIETQAGRMLTLRLSLTRDSAMPSSGGDNPRPSRYRLGVEVRSNSPVPSPVSYGSALPLPAIKGFQEPYPTSQLPHMYANHGSPRSHACLGSHLPRSEMLSVPSRTGSHHSGSSMTMRNSSDTLLEAERMWPQSPESIRVHAPSNAAQDSRHATHSPSPSHRGGVPRVLREPWADYDNEGRHHPARTRRRSASRHDSIAWEHGRRPDSDDDYSEQESEPERQSFDDGPHEEDCPSPMLPEEPTCIRLPSTPRPEDVRFVGQDAAIYQESSYLPTRIRVRKGYTLPTHPYIQPTDTDTRASGGWNTSAPGIPEEPPSRHYSPSYEAPDVDDAHRAGRRLHESRRGTLPDHCRRPPAFDHPRTVDPRADNVEGTRGPIRIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMJ1</accession>
    <name>A0A4Q9PMJ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_856871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMJ1"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020967867" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="17685" checksum="18CEE173E50A2523" modified="2019-07-31" version="1">MRLSAFTTIFAALLSALPMARPAAVERRQVIVWPAHGTTISPANGSTIAAGDSFQFLYKDSNFCESDVVTVAVYLSQTPPANSDVMANGRLADGTFEYYFGDYTISNFGLPPSSNAPPSSLTMPVLEGTAANTTLYFSVLEDFTDCPPNGQSTWFGIEATTVLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PML1</accession>
    <name>A0A4Q9PML1_9APHY</name>
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        <submittedName>
            <fullName evidence="5">Thiol methyltransferase 1</fullName>
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        <name evidence="5" type="ORF">BD310DRAFT_825879</name>
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    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145169">
        <property type="protein sequence ID" value="TBU55396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
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        </source>
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        <source>
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        </source>
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    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="223" mass="25186" checksum="D843F5763BFE62DB" modified="2019-07-31" version="1">MSAGTTENGPSRMAQLRQMIEEHKERGWDVAWRSDTTPWDAGTYQPALKEVLDDKALALSVDGRPLVPGCGRGYDAICIAKTLSLETLGIDISPTAIAAAQEWVHSENDDIHVRFEVADFFALTGVNLKFDLVYDYTFFVAIPPARRGHWGRQMAELVKSGGILITLIFPIDDDAQTGPPYYVRPQHYNEVLGEGWEVLLDKEPEHTLESHKRRERIVVRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN22</accession>
    <name>A0A4Q9PN22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_679328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7798" checksum="FEC036127B34F04F" modified="2019-07-31" version="1">MITMRPFSLQYLARLAICYTIIIGILVSIIRVAKKHVQGIPEELLVISFFLLVFSALDLGSRLTSISSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPD5</accession>
    <name>A0A4Q9PPD5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YOP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_968819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPD5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPD5"/>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21406" checksum="6D5CE98012F70658" modified="2019-07-31" version="1">MSATQKVQQHPAFIQAQDKANYYVNQLDKELSKYPALNAFEQRTQVPKSYAFLGAVVLLAVLHSVNAFASPVSNLVGWALPAYLSVKALESPGHADDVQWLTYWIVFGFFNFLESFALRAVLYYFPWYFAFKSVFILWLQLPQFRGAQTLYGGVVRPVFANISSNGSRLAPTQSEPTVTADGLRERVDGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ08</accession>
    <name>A0A4Q9PQ08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_823920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ08"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="611" mass="68922" checksum="7975F3C89A0EBF19" modified="2019-07-31" version="1">MDLRERKPSPRQTAPIPPGPSLKARTGATLIDRSPIQTDLAADSFTDAIRRMKAANEARMDNSDEALSEENVPHKKGSRRPLVSQAEEDEEEPEEDQNEDEGEVEDEDKGEDNAKGRCEEEDINHVKGDSEEDLSPADARRFLKAIRKSKKKNKSHVREADADPKRLTEHFKTWGRHCHRLCGLYTDIHKTIVCGMTVMRAAPHDADDYEACYKSIPHMSPATARFYTNKFFHLCDEIPLFTALCEHILLSPDDVFLFAKYMQVHAAAGRTTDISTLKTSFHSYFPYVIISNDYVIPPPAPGSMSDLKTRNGGYCSTATGRLVVPIDELAKFDLDPPKYCKLKVTQHKKIQAASSAMRRKKRHQGDRPQHSNDNNSYPSFLFPTNLKYDNRHPDRHIFKSDFVLSGPSAVGRTGGMRGFGRAPLVDIYSITKVTPDYLVYVVTLLRYLLSTDDRWNGNDGQRSGHCLHTALHRFLTVEYEAWEQDIEDDYLEPSEDPLEWNIFTFYNDKVFGSEAGAPDQQDPDADMEEEGNDYDDNVRAQVLKARMAELKARRAQHTKSGHNASPQPADDPRSRSSSYELVDTNTHFVEVAGSTSPPSENPAEPADDLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ28</accession>
    <name>A0A4Q9PQ28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_950087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ28"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="37821" checksum="497601BDF7A7FACC" modified="2019-07-31" version="1">MSSKITIFYIGATGYIGGSVLQAILAHPKADTFEVTALVRNETKAKAIEKALGIKTVLGSLEDDALLTEYSEKADVVFQNASANAFDATKAILAGLKQRFDKTGKKPLFFHTWGIAVLVDNALGEYLSPTVTSDYDLDTIDKLPKTIINSRVDKLLVEADADGYATTFIIAPAIIYGRPRGPLFDGPAPISALVTGVVTKWAAAAARKGRPGIIGKGANAWGYVHIDDNADAYCRLFDAALFGSAQVSHGREGYFWIEATEHTAYEVHKVIGEALVALGVIGEAEPASLTADEQVKFYGSEEYAAFFAANTRSKGDRLRKELGWAPKHTAQKEFIKDIKEDTEVAAKALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQD3</accession>
    <name>A0A4Q9PQD3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_931197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQD3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQD3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6 7" id="KW-0186">Copper</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="212" mass="22018" checksum="250AD63F7B37354E" modified="2019-07-31" version="1">MLGFPAEKTPSMDFSTARPSSRPPRLAITASFTLIAVFVIWLILPRRSDPQDEVLPLPVISKAVAVLNGETVSGTVTFTQLFPTAPVTVSGEVKNLKTSTKHGFHVHASGDLSNGCASAGSHFNPFERTHGAPTDIDRHVGDLGNIETDSKGVASFTFEDSLLSLNGPLSIVGRSVVVHAGTDDLGRGGDDESLKTGNAGGRAACGVIGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQM6</accession>
    <name>A0A4Q9PQM6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_605384</name>
        <name evidence="2" type="ORF">BD311DRAFT_364376</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143428">
        <property type="protein sequence ID" value="TBU27761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQM6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU27761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="14887" checksum="0DE0643E6753B739" modified="2019-07-31" version="1">MRLSWARARAHEGHSVVAASGGLCGAKAHMALGLSLSCHSWSLCIGPDRSVLRLTDSCTYRTREERRRGQERGSARRKGNTWRGSRVLATAPIPGLSASTHSVARPAVFPTGALEADAAQDGCCGDSVVATSDRSGRLSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQN5</accession>
    <name>A0A4Q9PQN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1023437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQN5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="193"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="847"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="784"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="968"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="977" mass="108357" checksum="C55ADDDC7B2671B9" modified="2019-07-31" version="1">MSISTGCISSSVFCSGESGTSGSQSTPLAPRSSNNPVNLLEDTLIGDRGVLKGWKKKLERKISLSDDTGSDFLAKYVPSSTPYTCAEVSGTEFDAFKPGEVSAYPSFIKGLNALVASFPDQKRLSFFDCHTQSQRFPYAGPASYHHKSYPDIAVSFPGQILDAETSHLDRPRFSMIVELKAENEDPFCGKGLQYCKTLVQLAVNARNLLHAHSLLAAFVIGVYGDMVRIARFDHAGAIFSQSLSLRVVDDLRIIQRFFWNFAHPNDGETVVGCDPTVRRLTPDDEEWLKHRLELAGVSTEGLLSSEARRAEVFNDDVSGNAGVSAAYILFKALDVNDRLFSRATTVWLGICDTRSLVNGRLVDLSVDSIPAEDLKVRIVKDAWRPVVRRSEKDFYARLSRVPPAERVGVPSLVCGGDLGEREVRQWESHMYGAPASDHQSRLSGFVSGTASSSIPPPSFSPRSAVDHLPVHRPMQQTFTWRQSRGSEYWHRERSHMRFVVDKVGRPLIKFRNTREMTAAIRDAIRGHRVAMTRAGILHRDVSVNNILIVDDPVEQDSFTGFIHDFDYSSMSREFPAANMASLFSELLLGDNDGGELQKRTGTFYFMAIQLLSDEGDIHGPHHDLQSFYWVILWVVLRHTDHTHPKGDEACPYIFDRGERASLAAKYSWLSGCLRKDLCVRDNVPLTVLLKEFGDLCVQKLLSDDQPLDYDEVLAIFDKVLDSDGYRDLWPAKDAPKAYKLPDTRIKDELSSGQRLRASKRKREAEKACGTRSDSETDMDDETKDFEPYDEIRRRPLPGRDGYANSVGASNPGRLIETDPSFTLCSPTRNYDVPLMEACEVEAILDCSDSEDQPDDAPDSSPIQRAKRRKTAVSGPRTSASSTKASTTLVGTSGSSLAKRVSMRELNSLDQSTVDVESWRGATSNTRSVGGGAAGPSRIQPGRNERSIPQASSNARAGRARATRGRQRSGKEKAMRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR07</accession>
    <name>A0A4Q9PR07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_600571</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR07"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="108" mass="11704" checksum="651D88F15DD6E911" modified="2019-07-31" version="1">MDPSQRSKTSPECGGEGACRVMAVCELLRALVVFLAPIVVLLLLELGATQRSVQSDGQYTTRYALAPSSTFNRAPGDRYNALRLVRASMSGRLNSDVGSRVTTLFCTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRZ9</accession>
    <name>A0A4Q9PRZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorbose reductase sou1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_570590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRZ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="333" mass="35669" checksum="CCB9DDD2AAD5BA7B" modified="2019-07-31" version="1">MITKFRGVRSITSQLGARRCSRLPFSTTASTHTALGQLTGPLPPYGRVGVARALEVSPTAEPTPTIFANEFSLADHVALVSGANRGIGLEMALALVEAGARSVYCLDLPQTPGEEWMKVNEFAKKLKGTGGEGRLEYISGDVTDQEAMWNVGKTIGDREGRMDICIAAAGILKGDTSCLTYPGKQFKQVIDVNVNGVLFTAQAAGQQMQRFGNGGSIIMIASISGHGANKGHPWTSYNTSKSAVLQMARSMACELGPQRIRVNTISPAYINTSMTGQFLATRPEVEEMWVEQHPLGRIGRPDELRGAAVWLASDASSFCTGSDFFVSGGYQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS87</accession>
    <name>A0A4Q9PS87_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_907295</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS87"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="173"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="381" mass="42863" checksum="061D5D1F48440990" modified="2019-07-31" version="1">MSDLRFVRFDDVRTFLEVTKQADDYLMKNSGALSIYDYLGAPTDPTRVFYLAIYRETLLMTLVYGIKEGFPWILSGHRRAEDVLTPETLTLAVTLLANSISTLQFADPSIVSPLRVFGVEEPVNAFLTAWVGIQRGRGQRIRLKPNPTTVFVTYATRNTLTPLPPRTLMSPQHIISRASMSDLESLMPLYMNFFSTKSWPTQIIPTEALTRLQRELPTGLFWVCRTDGIMSAFAELGSVSPRTITIRTVYVPPEHRQRGVAEALVHTITRYYVGLGAGAMAVVPPGPPPEGVKEQVKLNVADAAAEELYRRLGFLLPHQSPDGRALTGGIDPATGRPGWYRSIWRESEQEPDTSIRRARRNEGTPRKRDTSSFPDVYIYWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSM0</accession>
    <name>A0A4Q9PSM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="369" mass="40963" checksum="3B76CCCFB1C5E542" modified="2019-07-31" version="1" fragment="single">MYSPALEAALLEELLPTILKIRYAELASTVIILFDHVLTLDQEIHLIWHAHWSLGKLLFLLNRYYALCIVIFNNYVLFNTDTLSNSFCVHWLRWQGATGVITFIIAEMILQLRLYALYFRNKRILAAITFVSLGAAISSAYVMGQALSLITAVAFKFPLSGSTVCVPFGLPSNFYAFWIPMLVSESFLCGLALYRGFDSFRPGNNVVQSGRRVLEILVRDSVSYFVIIFATYLTNAIVFLTRPDAEVEIPIGFAVALSTVMSSRLCLNVRGYIRDAAEEPVVLSGASIGPTSGPHHSRAHSGRSVLAFISFGYGTEEDERAHTASAASTVMQGAPLNDVEMRELRVMRAPSTKQMRVMRIGRREEGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSR3</accession>
    <name>A0A4Q9PSR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_929382</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSR3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8173" checksum="80C5F2056DD5DB9D" modified="2019-07-31" version="1">MSDSALGYILDSGHIDNRHDRTHLSIGTLLLGILSTALCSISGLQTCLASLITSRHFLRSRTYRFLAVCMYKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSU5</accession>
    <name>A0A4Q9PSU5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSU5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20748" checksum="4FE8175BB6902628" modified="2019-07-31" version="1">MPQKMHHTGSLGVTAGIVGSIIGVAAIVSALVIVVRKWGDRLARKRAATMVGMDELGTVLVRQWTNTTAGVGERILDTARRSRIVVVDKWRATTRALARLRRSRRSGSAPPGPPTVHRLVNLSPLLYNPDDPRTFPPMPSPEEIDLYRRHKALQPMKCARSFTSVATGSTAADQSPFPAVAGFPRRPEGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT41</accession>
    <name>A0A4Q9PT41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_928955</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT41"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF867">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="198"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="370" mass="42684" checksum="23C6B7925AF9FB7D" modified="2019-07-31" version="1" fragment="single">MAASPTDLPAKMVPALPRYRHVSETQEILEWAYVPLIDFSMLHSEGGTAKLVSQVRDAMRTYGFICIINHGLMQAQNDRMMDIADVPFTQVPLEEQRKFVSRIKDLGEYKGYKPLRSWHIENGVHDQVDQYMVIPPTFKQDHPKPLVPFLPEIRSFMEHNHFKVLHPLLKLLALGLELPENTFVDQHRYQAEGKKFVCFSKYYPRSDSDEEKTKNVWMKGHTDGGTVSLLWSQPIIALQLMSPDGNWRYVQHVPNGIIVNLGDAMEMLSGGYYKAAIHRVFQPPSDQRGYPRLGLFYFAYTDDDVRLVPYEESPVLQRVGIRRQCDDKDAPTMKEWSIIRATLYGNSETTRQDDGMEVQMVDGLVIKHWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTQ0</accession>
    <name>A0A4Q9PTQ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dickkopf N-terminal cysteine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTQ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTQ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020614018" description="Dickkopf N-terminal cysteine-rich domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="15625" checksum="275B9F9CD2D1C6E4" modified="2019-07-31" version="1" fragment="single">MGTLALLLALTLSASANSTPGIACTTMNDRLDAATGKFTSDCDDASFCSEVGGANGTCQPRQCRRDEFPFGFANATVPPLCPRGSYCPDEGSGCRPLVAVGQPCQVGRDEQCAPPGNWQDLASGLNANGSVCLNSACTYVRRSLSWLGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTS2</accession>
    <name>A0A4Q9PTS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_533307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTS2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="254"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="690" mass="77253" checksum="7B184682AB2C375B" modified="2019-07-31" version="1">MISDFIHSQAQQRSLLGSSTISPGKMMRVLDTHTGEFKKIHPTEEAYAILSHTWDPAGEQSYHDLRRMQSKGLQSLFDHPDLSPKIREACSIARSHGYRYIWIDSCCIDKQDSIELSEAINTMFFWYSRSNVCYAYLVDVPNGKETDAQSRFHTSRWFSRGWTLQELIAPRALLFLSRDWQLFGTKAALSGAIEKITGIELSVLKQQKPLSAIPVIVRMAWAAKRETEKVEDRAYSLFGIFDVHLPMSYGEGDRAFFRLQAALLQTIPDQTIFAWGARLFLESPPKGRTAVLFRTPDHHASFVATTPQDFVDATRFRPFSGDLSPFGLTHIPIAEFRNTPYGMRTQLPSLPISVLFDDNDLKLHRSATTAQWYLLILSCEHPDKGGHLVARVCFSDTVGSHEPKLLQRGFVLLSTSRGKDQASLFDTFILSPTEVQQSHSKLIIDTVYLPFIWFSSSYSWDRSEYARQMASSAPDNSALSVQLTKWSEVALRAQGFEPEVRHSTTRDSLLVHHYHFTLRRCNVSISIELSYHPGSSHGLFYVASSIVPTSLGESVVESQDSPPASVTGEYGASGFPDLTLTTPTGELTLVIGLDFDPLLRESDKRDLCYVNIQVVESPPESPASLAHPSSDAPHADLYGTTAHTCLPSLSVKHFSALKRRLEWLRGCIGRGSLEAGRVVDGTTLTETRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU19</accession>
    <name>A0A4Q9PU19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_928055</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU19"/>
    <dbReference type="STRING" id="114155.A0A4Q9PU19"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="91"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="971" mass="110758" checksum="4D60C056D4C0553C" modified="2019-07-31" version="1">MAHRPRPQVTIPPGAAPPSNPSPSAREPPLSPINLWADRRRSSHSPYTPTATSSYFSQRISLDVPGRPPSRAASAYEGDISRISLPEPQLFRSSSQRSTYRLNGPVHTHRSTRSESVLTPDSLLTPTTYPGSIHSSGDSGPPSFENTPELYVKDLSSELSTLSIDSDEALLKFHRGQLLEIDELWYRLVPPEAREVLDQKEVQRQSILFELVKSERDYVSDLELVQEVFIDPLRNTLAVPDNRIATFISETFFNINQILAHHQRMLSALFDRQREQFPLVQSLTDIILDNSLKFRQDYEEYIAHYPLAEMRHRNEMRRNQRYQYFLQQCSHNPRVRKRDLITFISRPVTRLPRLLLLLENIKKYTDPDHPDFEAIPLVVGILSDFIKGAQHGIEEAEEKVHFWSLCESLTFQKGEIIDLDLYDAARSLQHQGQLSRRYRSEMNFHWADLHVALLDNYLLLLKPDARPNAVIRHAVVSRPIPLDYLRLAAFDGPPENRKEKSEEGSLGLLDRVRPRYRPMFPFTVYHAAAKMTRRYTLYASSEAERQKWEEVLQHTLRMRTIRQEGNKFFEPFVINDGFFKRPELALINNPHAAGSHYTGPVTAVTKMYSNGVKFRAVACPSGVYIAQKDEPAFRKVLDVDNPTCLVAIEEVNKFFVLHDYGLCSYSLDLVARAALGMSSVQSVEASRERLATDVVFFRAGKIAKRVVVLYVSRKYYAVVAQLSALEVVNRGDPSASSRRIANGLHSFRPFGESLTIPKDTHNISVFNNHVVVCSENKIQIADPANLRLSGSHRTASFPDFTDAETQINLPMSSLKNRCQSAKPLGLIRCPKYDKDDKDEFLVIYDELGCYTDQHGVPTRNSGYLRWEVKAVSYSYRGDYIILFSPEFIEIRTVRTGKLMQVIEGEDIRRVDVGLLSDGRDATTLVAWKGREERGLVVDTLVELIETAPLQHSSSRASEVRSEQQWADFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUG4</accession>
    <name>A0A4Q9PUG4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_498671</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUG4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="11679" checksum="159751FE9B4382E4" modified="2019-07-31" version="1">MAGIESRGLGRQRQSGGRGLVRTTWGGYFARSNLLNTESCDRLPRMHMCLTSNKMSERAISLRCSMLCCGTAWYMNADELYVSEKYLAVGRTTSQARMALHPVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV19</accession>
    <name>A0A4Q9PV19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_493535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV19"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="18809" checksum="9E57B5C888C8BEE7" modified="2019-07-31" version="1">MEIDAQLCQLLGTLSLTGQARKATYASEEQPQRSQIGFAGDAVISDYSNSEDSTCQPSLSRFANVSAPLPPPPNCGCAYLQAVHEQIRSGKYGTTSGDYLETIFTHRDALFAFPQGHRSCAAGFTELARDLEQRDSRGQDQSVNGGWRPDWDGDHEAVVAFRHEAWVIANSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV95</accession>
    <name>A0A4Q9PV95_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_948681</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV95"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="246" mass="28410" checksum="7F23E46C4FF7CE79" modified="2019-07-31" version="1">MGLFYEYKPPSPDVQHQRLVALRQLTARGFPCILWGEDALNYVHSVPTSLFDQQIQEGRYVPIPFTPHYSDFFGVNVGKSPFLRGILLKHLDIPDDEPYKLDPLPGYILLLPQSYFGLDVRSKDRFQTLVPPLDASNAGILAPKFHTFLEGLVAFNINPPIPLDTPHGRGRMNHEVFIGYLMRYRVKYEDDGNTPPPKELLPEERVILSELQTEDARWYMGVYLGERRMLSLDEIKEYDHRKVARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVJ9</accession>
    <name>A0A4Q9PVJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_1013329</name>
        <name evidence="8" type="ORF">BD311DRAFT_781308</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143490">
        <property type="protein sequence ID" value="TBU23962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVJ9"/>
    <dbReference type="OMA" id="VGQKRIG"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000026">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF1">
        <property type="entry name" value="ASPARTYL PROTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="99"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU23962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="416" mass="44921" checksum="2D9B5DFB3DBC7B5C" modified="2019-07-31" version="1">MQKLHPLVRPAHYQGKRPSFQAAYARAARRYGFETGRNAGFAKRNNVVVKVKSKHNKETQHEVPADSIQNVSALDTPARHDVGMNACSHPHVLFSSMEYVVPVKIGTPGVTLNLDFDTGSSDLWVWSSELANVKRNAEGHNIYDPSKSSTAKKASGSWNISYGDGSSASGNVYTDTVTIGDLAIPGQAVELSEKLSSSFLQDNGNDGLLGLAWPSINTVTPKPVATPVENLINKKLINPPVFTVKLTRGDTEAGFYSFGFIDTSVTSNPITYTSVDNSQGFWQVPSASWSLGGSKKERSGNTTILDTGTTLLLVSDDVVDAFYGAIDGAKYDDQQGGYIFPSSATIPDIEFAVGDQLYKVNPQDITFGDAGNGYVFGGIQSRGNMDFDIFGDIFLKSVYVVFNQGETKVGLAQRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWN9</accession>
    <name>A0A4Q9PWN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_764829</name>
        <name evidence="3" type="ORF">BD310DRAFT_774055</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145399">
        <property type="protein sequence ID" value="TBU51098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWN9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWN9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20819" checksum="CBC4DE89E89C0D9B" modified="2019-07-31" version="1" fragment="single">TLGQTLRPGGQFARLETKLRSQLRQSMNAELVRLSGFTRAEMRWTLDAYLERVFYSLGFKLVGWPPDVPFANLSNFHGLPLIKHIRSQWTSGVMHFAPVTDADRENARRDRLSAAPGSLSHDVRTPSSRSDIKARRDRPKTNPENLPYRHVRNGPKSAKEVSAEAEAAADAEVWEARERAAASEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWU9</accession>
    <name>A0A4Q9PWU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_434693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWU9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="22781" checksum="4EAD6F7473D2DEB2" modified="2019-07-31" version="1">MASASLIWCNISMPYARPPHSFYRLSSLGVGLGPTCSVVKGSLAPPARRKSRQEIDIHTRSGIGTAGCYEPCAGVHAALLQMCGCRYLAPHPHCTFPAFLPPVDPCLLGQATPIRASNSVCAAPPNERAAPGLRFRDESNARRSTPRRCLNPRPLATNYGRHQRARSVARPYLIQQNTYMTYPIQQNTHRRTPGTSQQPTQSETCQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY52</accession>
    <name>A0A4Q9PY52_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycerol-3-phosphate-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_924416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY52"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY52"/>
    <dbReference type="OMA" id="PENPWID"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="477"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="656" mass="72565" checksum="8460BB0A27C94AD0" modified="2019-07-31" version="1">MSDAYVAHRVIRRIAGWAVISFFSEIHVVGGENVPKDGPILVTATHHNMMLDPAILSIAFPYKRILHYWAKASLFANPVMKYVLTSAGNIPVDRKAQDKRLLFRGTFRALAKGKAVALFPEGTSYTEPHIMQVKDGAAWAALEYVKWAQENPDKVGKGAENVMIVPAAIVYTNKSKYRSQVIMEFGQPIRMEGYLEQFMSGEEGAPRAAVKRLTAAIEKELTQLTINAPDWDTLYAARMARDLLWQGERSINIDEFVTISQTLVDLFSTPDLVPNINAIKRYLLTYYSLLESTHLTNSVLSSLPLPATLDPRQPVPLPSRLLTLSVLIRDSIALLLPLPFYIVPVILHAPAYAMGRFGARLVEDEEETQAQNKVVFGLLLLLMIYPAAFFFLWAFLWYTPVGALVAGFLVFLFAMYHNRLINVSYDRAKRLVAAWRVLVGVWAPKRWDLSLSAVAQYTVPRIPPENPWIDRSKAKATSRPVTPASSSPSVTRGPAESPASSTPTSTPAGPSTSAGSGPGRRRRPPSHRLIRHVLRARVEAAKALASLFAQLERAPEGKHVCASVHLAQAFGGYVETPKEPSRETSAGVETVPEPQGWRSAREVVAFLRSRGAKFRALEARVEGDWAALSSEGEGYESEGVSTSEMDDIVWVPPSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYD7</accession>
    <name>A0A4Q9PYD7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_370554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYD7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="186" mass="21450" checksum="0E8B2C6670F71706" modified="2019-07-31" version="1">MSGTPRCCCLSNRCSRSHFRLKAWLTVTAMSQMAAEWVYIHETDRSPGAYTQHLPSFPCLYIMDASNSANNAPIKFPFSKDQTIGADLLGTFFGLIFYGLSVHQLYKYYRLFAVDALIIRILVLLVMALQTLHAILTMHFCYHILVTNYFAHQFEPNVWSLEVSVRWHERCITLMPYLQIALRSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYJ9</accession>
    <name>A0A4Q9PYJ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_368489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYJ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYJ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
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        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF5">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="9">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="132"/>
            <end position="158"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="173"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="445"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="549"/>
            <end position="599"/>
        </location>
    </feature>
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        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
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            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
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        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
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        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
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        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
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        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
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        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="599" mass="62652" checksum="DF4B878095C58AA4" modified="2019-07-31" version="1">MVFVADKKYACETCIKGHRSSSCKHTDRPLFEIKKKGRPVTQCEHCRELRKTRQIHVKCVCENKEASEEVPGPSGSKGGPKLPARAAFPSGLPEDLLEASVASQLFSEGSDSDQSSRGCSCKDGATCTCWTPRNRGKRAAKPHERRNSEARPISTSVDGVISQPAALVVHAHAGGNRPVLPKPAAERPSSPPRTSHSPSLTQSGRLPTHGQSFYSPYSRAYEYSHATGYPSMNEGNPFDVQGLLNTASNTASSFGAWPPGAEGSPLETSPLSSPPACGCGASCACPGCLEHNGPNADLTAACANPNNCVACVECNINILAALATGNARAMYDPSGMQNVDDWLRQVPSMPDITSPTMQSPIFSPDQSQPDLRYDPSMLQTYGMWNEMQNGPVQQTPTINEECCGGQCRCPPGMCRCDADRFDSASGRTLTFAVSGERAPCCGGGASSPARLPATGPGPAAGPSSRANLAPPNAPRFAEGTWLSPTLAVPRTPLSRASSSSSKSSPHPSTSSSSPASFGDLTEGSAAQRGAPSGSEVGSCCVSMGNLSTNVPTGSSSGAHSNRRGSDHNEYRTRGSGSVPGSSSASVEYHSAVQTQGRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0V5</accession>
    <name>A0A4Q9Q0V5_9APHY</name>
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        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1037791</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
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    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="48"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="594" mass="67509" checksum="2518DFA9FEF605C9" modified="2019-07-31" version="1">MSALYVNNITPVIQSDTDTPRSEIEDEIEQHFKAIITLKRLLNAKVAISRLPSELLAEIFECLARDPHSRPEMARGAYISAIYGTSLQWIRTSQVCHAWREVALTTPRLWSFISVTRRDAFEAFLARSKQAPLSVCIDNLSFYESCKVLGELLPPELYRLRELRFSGPVRIVHDICANLTQPAHLLHTLRLVIPDTEYSSPSGPSLLQDDLFCGQVPRLRILEIRQITINWDHPIFSKTLTSLVVIRGSHGGDFEQLLFALEQMTYLENLRLDDAIPPAPSHTTSLPAPSRTVALPSLRHIRLKGFAVDSANLLRHLSPAIDPELDIVTSPGQAVVQDLVDTLKSQLTQMKPLRTVRLAQAYGPKLALYAWRKDINFTKSDSDRYLSDFDLGIPLRLELSSPTLSEGTQRLFSDSSLWRSVRYLQVEMDFDQSWVWRDIISGMPGLRVLGVLYGVEKSLLDALSAVHPAEKSRAPSVVLPHLEVLSFSDTRLANLSEYMVEERFFDGLIDCLILRCNYGTPVQEVRLTDCRNITVEDVARLREIVPQVAWDGVVEMEESEDDEDEDDDYDDTEEDYDDPEYDEDYGLDWDDGWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1H1</accession>
    <name>A0A4Q9Q1H1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_921722</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Rho GTPase activator (Bem3)"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
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        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF129">
        <property type="entry name" value="RHO GTPASE ACTIVATING PROTEIN AT 16F, ISOFORM E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1334"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1369"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="499"/>
        </location>
    </feature>
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        <location>
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            <end position="698"/>
        </location>
    </feature>
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        <location>
            <begin position="977"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1404"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1444"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="645"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="983"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1119"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1164"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1414"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1450"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1499"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1539"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1558"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1576"/>
            <end position="1585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1585" mass="170141" checksum="F3D68CA91FDF40CC" modified="2019-07-31" version="1">MATPNPPRILTNGTPVRDRLYRSDYPPSATNSPATMRPAASFPNPLASNASIHPNPNSAVPTTQPLTVEGLLANNGNSISAALDAAVNERNALSAQNTQLWKLIEKQRSGYNHLMKEVERIRGERDLYRNRLQANGEHTDALLRAHRAKEKSEGKDSTLRPTASHSQLKSSDSSASNSSSRGTPSASDPRSHLMRTHSDDSPARAQHLSTSRSFDPSQTASPSARFTPERRGSSDTMQRAESPVRREPPNGHVLASQASSSAHTPSPLSISSVERPADIPVTPRKSPPLSMSPTEESFPSAAPTPIPARSASLSISSTPTQSPSTATRSAKPLYPSDPADPVLGGWEAQGAPLPAPPEIPKQQLQSQTQLQNGVLLTPATPVRTASTSRDPEPEPPRAPNGHLTNGRHSPQQAPPVNTPPSSQSVAIKVNGVSNLNIRQPSASRDSQISLPEEAKRYYASMASPAASPGMKFSFSSNSNSPLRQEDVASESTVHSESIGVVDAHRASPQSGGLGTPGHIEVAGGAMAVEARAETNGRSGSRDRFVDDAGEFLDMDDEDSAYDIGVNGTSNGQYASRPSYDETEEASAARKREKMRSTRPSGPAVEDFPLPPGTTSVPPPSAQYQRETPSPGSAPSVHAQMGPPSRQGSVAEATSTARESRPSLQSTSESHSHQTISLASSQTLVDAQPPASPFPLPLPANPPTMSFRALPLLAEDLPYTEVVVLNSSIRPNDKGKEVLSFIISVDPGRGKDSWKVEKLYSDVLGLDARVRAAVGRTTSRKLATLPEGRLWRDHAPAKVDQRKVALEAYLRSLIALPVKNKDETIAFFTSDIVRETQKPVAQAGYKEGYLTKRGKNFGGWKTRYFVLQGPSLEYYESRGGTHLGSIVITGAQIGRQQRQTEKRDADDDNEYRHAFLIIESKRSASGQASRHVLCAESDEERDSWVEELVRYVSGQYNEDQVAVGTNVVSPVVAMPQGAIREPRSSTSSNPPTDLQGTPRRSTKDILIAKGPAVPLSQLAQDSSNAKLFSTPVYSDDATSSSPAKSSIVASLTERDTEMQLSSSLPVSSPLVEEPDVVPALNPRSNSELGHYSDLVDQRASAARSPEQRRKMKRMSMKPPTIRERSASPEKDPNTPRVDAHGKAKISGPMNGTLIPDGYKFGAREAPPPEQAPPHLPTSDRREKTKSRSFKNWGFGKSHGSDKAPPVAVPAYIPRAVFGVSLEESLDVAQIASLPAIVFRCIQYLEAKKAEQEEGIYRLSGSSAVIKGLKDRFNAEGDVDLLASDEYWDPHAIAGLLKTFLRDLPASILTRDLHLRFLSVIDFVDPQERIRELSRLISALPIANYSLLRALTAHLILIVQNANINKMTMRNVGIVFSPTLGIPAGVFSLMLGEFKRVFNVDGTLEEAPAPTDQEEGQAQSAARRNSQHYSEAAADQMLGLAGRALPVQQEDSPSDDGEDIIEESGTEATTEDAESVLDSSAGSTSMHAPQTIQIDSAGPSDFSQSGQRSRAAQLAATRGLSVTTSDKASRRHSRMVGLPASPRPPPQHPPPSHGASSGQGTSPSPHTGESATAIPHSPASNSPHRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1M6</accession>
    <name>A0A4Q9Q1M6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_921844</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1M6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="20039" checksum="D75E50DD10AF5433" modified="2019-07-31" version="1">MGLPARIRARREALARHDAALQDCRARVLRLIEQVNEAHPALEAHLVDALSTVPPQLHATWAAQADVVAATIEAALLKLSLVRARAHRALYGHAPPNRPDATVARAVGAAYDRLRERRRAQDAEMRKLDGQIEEYEGMLRLVHGRHGSFAQVVQDMARVKRETEECRKDLRRLGWTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2G2</accession>
    <name>A0A4Q9Q2G2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2G2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2G2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="755" mass="86555" checksum="35F48F89E89FABE2" modified="2019-07-31" version="1">MLHHLKDKLHDKVHGFHELITCTTSHVVELSDQVIQQLENDAEVALHAMTEHLQQMSDDGIPLKEANAIARKVVTGIDKVLVYLEFVTDTHPMAKLVVSSIRTVVDFEKARQENTVLIARIHASMINAAFHMRVLAPLMGERDVLSHTMNSVLQAMAVTIKEFGAFVDLYNRNRQKIFKFLMAQLHNKQLDQFSGNFEKYRSQLHDICMTRATVMTQRKLNAAQEQLETVIKNTRDIKESLQDLLGEDAETIAAVETYVTVNGGFEHVIQDDHLLDHVGELLGENVSHRVKTSLRHNYEDLLKEHAERYEMKLQAVEGNMIHAIKTSSSELSRQIKEGPHELIDDADIKEIWRSNGWKSSVKCRVFIEGLREYYQYKICKKSDSIENLQDAWTVDFFARMMYHSAISDLVDEDGSGFVTATEVNTFCSTKGRRPPQWTTPQWLAFCASGWYNNNAWYYSRIKNMLKQIDAEVQKVKSSEPGWNHLQTIVASLKPLLFIEDVDGDEELQDERKDAVHHLLRLQEDYRSSELKWIQPNLEKLQYHLDDKAAVTAAMGDHRIELHIMCILYLFVEHMLKEITEHGNIHNVEDVAESCMVSYLAFEDRIHELMRGWRSQGRDVNLQLARYADGLFRNIEREAPKRKMAMETLCTLLFGTRSTNAARYSNMIRAASRHSPHSQLSDLVARMGDVVSTQDELVHQMSQVVSEQASLASQVADLSKKMDRIEQLLLGRPPFDVAHSFADRNPHFMGHSRGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3K4</accession>
    <name>A0A4Q9Q3K4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_812950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3K4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="19881" checksum="045F02F3B33DDA6E" modified="2019-07-31" version="1" fragment="single">IFTSPDIVNGSFVLAVARKSPGTYLVVLARAYGMAATHLYTVLNSSTPRSTVPPLSSAGRPLIWLDADLDRHPAQLGPPNGVLAALRAADSEIIRPTGRTQRMHAELGGERDAHEVELILDEDQLARCCWYCDALELDSDVRDNYRFPLCSGEGYTSTYMCQTCAQKSAFARAISSFLRSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3N9</accession>
    <name>A0A4Q9Q3N9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carboxypeptidase</fullName>
            <ecNumber evidence="6">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_921007</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S10 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="6"/>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3N9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF64">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033928" description="Carboxypeptidase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="491" mass="52951" checksum="DE63BA0C5751B141" modified="2019-07-31" version="1">MFLRLSALTSLLAALPVPTVLGGQFPVVNGVLGGVGSGSLPENRIKLPDLQPAATTPGKLRVTENSGVCETTKGVYQASGYGDLTSKESIFFWFFEARNNPDSAPLSVWLNGGPGSSSMIGLFQENGPCRIKNDSSGVSLNPNSWNEVANMLYIDQPVGVGFSHGTLNVGTSQQAASDFWKFLQIFFSDSRFSKYQKNEFAIFTESYGGHYGPTFAAYLLEQNAGIANGTVSGTPINLKYLGVGDGLTDPLSQYPGYISYAASNPYHTLVSKSTISSANKSWTKSGGCKDQITECYSTGDESTCSDAQSYCNNDILSPLAGDWDVYYVPTENPDPYPPDLTSYLTSKAVTSKIGAESTWQETNDDVYSNFAETGDWMHNSRPNLETVINAGVRTLVYDGDADYILNYKGVEAMVDNLQTKFSAEYAKQEFANYTVKGVATGLYKNAGTFSYVRIFGAGHEVPAYTHGSLSTGEAALQFFTQIISNSSLVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4T1</accession>
    <name>A0A4Q9Q4T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_812679</name>
        <name evidence="2" type="ORF">BD311DRAFT_774139</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU61614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q4T1"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7593" checksum="43DCCF1BFE714A59" modified="2019-07-31" version="1">MKEATAINVQIHVEEFKKELTREVLHMTQEVTRLQRERQGLEQQIADLFAFYAKQKQAGKVSVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5Q5</accession>
    <name>A0A4Q9Q5Q5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">SWIRM-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_842843</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q5Q5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016514">
        <property type="term" value="C:SWI/SNF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02336">
        <property type="entry name" value="ZZ_RSC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000020">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041984">
        <property type="entry name" value="Rsc8/Ssr1/Ssr2_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIRM" evidence="13">
        <location>
            <begin position="139"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="12">
        <location>
            <begin position="332"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="14">
        <location>
            <begin position="397"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="402"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="499"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="704"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="619"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="59"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="499"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU62639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="725" mass="77697" checksum="62783D78CE4B5D65" modified="2019-07-31" version="1">MSSPKRTASPAPNPSETKRIRLTVNQGVTPVDPENAAGKRSEFEPIQGGDVGNLPPAPAAAASTEPASAVPARLLKAEGDGEGGDDSGDVSMAEGADAADEEAESAEENDDEDPAQLEATRLRLEEQARKYLAAQTHEVIIPSYAAWFDMSKIHPVERRALPEFFNSRHRSKTPAIYKDYRDFMINTYRLRPSEYLTVTACRRNLAGDVCAIMRVHAFLEQWGLINYQIDPDQRPAALAPPFTGHFRVILDTPRGLQSLHPGTRPKPEGQAATGVNGSAKAGSIPTPASLELRSSIYQTSAKSSRPVSAEEAAKLANGASAPNGISGDNPTTIKYQCDTCGVDCTPVRYHSLKVKNFELCPPCYLDGRFPSNMFSGDFVKLTSASGANGVHQVAGGGVDDDWTDQEILLLLEGVELYDDDWSAIEEHVGTRSAQQCIRKFLQLPIEDPYVAAEGDMGPLRFARVPFEQADNPVMSVVAFLAGVVSPGLAAEAAKTALHELTDGEKKDTEDGEKKEEESTVEGEEKKDEERMQEDQPKEGAERPEGAPAPSDTQPDDMQVDSVATSEAVAQKATKTIPHSRVVRAAELALKSASKAAGTLADAEDNQIRSTLASLIKLTLTKLELKTAQFEELEELLEEERKSLETARVALVNERINLRRMLDHVKSELAKHGQNPGPGLAAAAGQAQAVLANSTQGTRVTEVQGGAPMEGGLGPVGEGANVAALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q646</accession>
    <name>A0A4Q9Q646_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_918536</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q646"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="234"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="647" mass="73205" checksum="2E9240E9EB63E8D7" modified="2019-07-31" version="1">MPLRLLHTRTLKFQEFHNPHSVDYAILSHVWDKDGEQSYQEVLDAIRQEHTSSGSSTDSRICEKIRRFCERAAEDGYEWAWIDSCCIDQSSSSEVSESINSMYNLYRHASQCYVFLRDVDDDDDPRQRASQFRRSEWFRRGWTLQELIAPAVLVFLSKTWTPVGTKDSLARVVQQITKIDAGVLKGYVPLATIPVGVRMSWAANRDTTREEDKAYSLLGIFGIHMTPIYGEGHRAFVRLQRAILEHIPDDTLLGWGRTLYLNTPPDFGLLSSDHTFANHELGFYAPSPQLFKPTGDLKPIPQSALIMLLGLSSESPYPTIYANTRHGVSAHLPLLYVRHEDHPIDIALGFLPCLDSRNRLLAVILRRSASDPNQLVVGSYTSQNPGVERYFRTVRIDYAALKFWMMYTNSTPRVESLYILPHDPLYRSDPRSDIGRHPAPHRGKCSIIVPSWRKASLAKQGIVVQQTAIDDSSLHPEWCSRRHIIVLSRAGMGAVRIILGFCEHCKPSEIAEPRDFKVWPGFRLQLQSCPDPYDPASLEHDATIGSCRFSPHPSGKTDDGTHVHLWPSGHSGESVMEFTLADQSMRLSLTFPTSRQGLVLTVDVDFRENGFPTTPTNSFVDSIDEPAQKRERDGEGDSDVSRHLCAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7B2</accession>
    <name>A0A4Q9Q7B2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="1">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_956199</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="10">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="1"/>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7B2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7B2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1010.10:FF:000006">
        <property type="entry name" value="Siroheme synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028162">
        <property type="entry name" value="Met8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050161">
        <property type="entry name" value="Siro_Cobalamin_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790">
        <property type="entry name" value="SIROHEME SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45790:SF6">
        <property type="entry name" value="UROPORPHYRINOGEN-III C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13241">
        <property type="entry name" value="NAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14823">
        <property type="entry name" value="Sirohm_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75615">
        <property type="entry name" value="Siroheme synthase middle domains-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 10 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Siroheme synthase central" evidence="14">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Siroheme biosynthesis protein Met8 C-terminal" evidence="13">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="12">
        <location>
            <begin position="288"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="163"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00035662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU62494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="575" mass="62041" checksum="399B8A6DC7BB8E23" modified="2019-07-31" version="1">MEAFPKPVGGASMLLAFRPAQRIVIIVGGNTLAASRAFTALEADAKVIVVSKGGLEGACEELRWRASQEQLDLVDIDALPCIHCSYDPALSAARECRHLRIPVTVADIPELCDFSFMSSHRFADPGTGRPSPLQVGVTTNGHGCRLAGRIRREIVAGLPKEVGGSMEKVGRPRAQAKASDGVGEEPDLNEDSAPFTPNEPVPQRKVDETETEKEHAWRRMKWVAQVSEYWPLRRLAQMTDEDMAAVLDGREGFRSATPNFGDSSQAGDQITTPLHGLILSPPPRRGRIFLVGSGPGHPSLLTVATHAALTKHAQLVLSDKLVPDAVLALIPSGVEVRIARKFPGNADGAQQELMDAAVEAAKRGLTVVRLKQGDPTVYGRAGEEVLYFRLHGFEPLVVPGVSSVLAGPTFAGIPVTQRGAAESFVVCTGVGRAGKEVKLPGYDRARTLVILMGVARLPQVLEALQSVDQESSKRREGLAYPSLTPIALIERASMPDQRVIVSTLRDIPAALESVGEQRPPGMLVVGWSILSLWDKGDVSVLDEGADARDGERIRTWLADKPWRVTEGLEAGWQDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7I8</accession>
    <name>A0A4Q9Q7I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_582205</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7I8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7I8"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020052">
        <property type="entry name" value="Ribosomal_eL31_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01144">
        <property type="entry name" value="RIBOSOMAL_L31E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14449" checksum="0B03A3E83EB6A316" modified="2019-07-31" version="1">MAPAATKTNKKGGKTRSALQDVVTREYTIHLHKRVHGRSFKKRAPWAVKSVVEFAQKQMGTSDVRLDPKLNQALWAQGIKSVPHRIRVKLERKRNDEENAKEKLYTYASHVPVESFKGLETVVVDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBC6</accession>
    <name>A0A4Q9QBC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_913820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBC6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBC6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="288" mass="32015" checksum="A1594C56323360A0" modified="2019-07-31" version="1">MVSSEGATREVHSVFAAAFPDGDVTLLSNDDVLFPISSSTLSRASPWFRTMLGLPQNSPETSGVESVIPVSESSEVLLGLLSMISSISLPTLDNVDSIEPLLHAAEKYEMTMPIAIIRIALRTLVDKSPIRVYDMACRMSWEEEAKAAASCTLRMDILSENTATELARLEGPHLMKLLMLHERRRKLVAAALADPNLFNAGNKFGRRCCDELEDHTDWWALKVAWLTKPWNFVCLGREGDETTAVPSEVELMLEGKCPKCSRNFYQKTCTLETLRGVARSLPQTIEWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC46</accession>
    <name>A0A4Q9QC46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_953511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC46"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="288" mass="32011" checksum="7621EE5DFFBA5DC5" modified="2019-07-31" version="1">MSRPPVQCKECKEEHGRITGHSAGTGYYCDECGFVGKWKKYRDHVPSTGHTRRVEHVPGSARGEHFTTQHELAVHRDTTQFQSPPRANECLVCGEETTTGEAHLECLDNPVCCPNCQRQFSTGAALAEHVKESSPCPTCNICTFRGRLAKHWLISMNHPKCYDCKLGFEDMSRWSQHKAICPTSLSLRSSKASRSEMKSDTGTAEASTPSVRFGADDPSTTVHDTASGPEADALSWHCRLCTGEVCIEPVVTVCGHIFCHRCIVQELGENMRCPVCKKAFFIRLHTRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC97</accession>
    <name>A0A4Q9QC97_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_942883</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC97"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC97"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021009718" evidence="3">
        <location>
            <begin position="19"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="33650" checksum="CC93BB8B6B2093D6" modified="2019-07-31" version="1">MFLLAVLHIALDIHIALSSFLMEHRSIETIATRLDTFNAVADAFGAAKFAIYVTQLLIGDGVMIYRAYVVWDRSFKVIVLPCVFLIGELILGYFISLAGPYAPKSWAMNTTALVNAFFLLSVVTNLLSSGLIMARVLSFTSRTEKFKRFSQDLQDGRFKSVTRRVVESILQSAAIYSIASISLAVTSFANYTVAFPACHSVFPSVIGMVFLLIVMRISSSANATSSHGSMLSQTGGSTLSLSSVPSGEEKPGFDAERDGHGRSLSEQKDRWRLSSPIAIHVSVSRTSDYEEVATLSPSSPPVNGAARPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCS7</accession>
    <name>A0A4Q9QCS7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UFD1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_1033894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCS7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCS7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="141"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="352"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="243"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="355"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="464" mass="49577" checksum="14B4422B204FAFE8" modified="2019-07-31" version="1">MDFFDQDHFGGGGPGGLFAQLAQGFGGMAARRIGRPNPRAYDEYFKAYSVAMLPGRPRDNVSYGGKIIMPPSVLANLTNMELESPWMFKLRNPGNPAASTHAGVLEFIAEEGCVHLPRWMMKTLRLEEGDPIRITGCELPKGKLVKLQAQSVDFLEISDPKAVLEQALRNFSALTQGDIIEISYNSIVFGLLVMETQPGGEGISVLDTDLEVDFAAPVGYVEPERPKAAPQPTMRDKLNIDLSSSTPGSSRPSSSMGFAGAAAKGPAISKGGDQWESFKGKGETLQGRKTKGKGISHRKAEAAPEGSKIIRTDKQRIVTADALDNDAYVPAPLNLPFGQLFFGFNIQPYVPPSQEPSASPPQSNSFAGTGNTLTGRSQPSSSDKGKSKAQSSSTTNWGSGGQTLGRRPTQPASSTPRSVGAGGASVPVLPSRGRAQQQQAQRERSPTPDFGVDDDEDIPYYSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDA1</accession>
    <name>A0A4Q9QDA1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_914219</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDA1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDA1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043938331" evidence="3">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="370" mass="37827" checksum="FD1E1F7C3234E162" modified="2019-07-31" version="1">MSYLALSTFLALAAAPLGVVAQSATSSSFTPLASKHFSYPSGIPYQADPDDGVRGTQQGYNLCNSTTEGPNSLCQTAFINHADDWCVWAPPIPNSTIGDTEGEEVAWCTKKGRGTRIIPAGAITGLQFMKTPGYLQIVGFIDQTQINIAADDGGGELDPHGADLRGNPLGGLVYSNGFPSNGGNNNSFQQVIEWHNFMGSDQFCFKVCDPAGSNAANLCQHIFDRIGVAYNCPNAAQNGTFESCEGDNQDPPGVYTTNGQVVTYSQPPESLGPITSLPYTPKIPASSNCVQFASSALFTDLASTTTSGSGSATATGSGAGATSTGASASRSGSSSSSAATGSSSNNGAATMCISILSTIGGVLAAVAFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDS7</accession>
    <name>A0A4Q9QDS7_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_35098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDS7"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12994" checksum="20DED268CCDBAC5C" modified="2019-07-31" version="1">MASPRSRHTSDPPLPVTVTPFPLASILQYVVVRPWTIPKVRSLLHSRPRTPSRQRESSPGFCPSPIMHRYLPSVAAAPISTSSIVPLGSPPSITMSLSRCCSDRDSPGQYESQMRRPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEC6</accession>
    <name>A0A4Q9QEC6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_803506</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEC6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEC6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="180"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="217"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU66177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="296" mass="33697" checksum="D11760DBBF228C88" modified="2019-07-31" version="1">MANTTVRGATAIHGQNPQYLVESVIRNRIYDSSYWKEHCFALTAETLIDKAIELKAIGGVYGNQKPTEFLCLLLKLLQIQPEKEILLEYLQADEFKYLRALAAFYIRMTFRPAEVYEILEPLLKDYRKLRYLGMGGYTLTHMDELVDQLLTEERVCDLILPRITKRDVLEDLGEIGPRKSRLLDAMEGKSDHERSRSRNRSRSTDRSKSRSRDGSPRRPAGARSPSSSRSPSRGRSASKSRSPSVGSRYVSRSRSGSRSPYRSRSRSISPDRVNGGSPGRFRSRSRSISPDRMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFW8</accession>
    <name>A0A4Q9QFW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_912870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU66151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="540" mass="60532" checksum="10B89BFC8DD60FAA" modified="2019-07-31" version="1">MSNNHGTRRFSQVVNGLLERFGSPGQATHFPGATQTSTLLALPDDILLLVLALIDPDDLLICKQVCMSLSRLVQHDVRSQYRIELAVTGMVDGPPSDITLTDRLEQLREHRARSHSSHFSRDESIWTEVDARVQVLTSDGTIVYAMRRPGGYKLDVRTPLRVQAALSLCSYCLSIEAGQESHIEAMDMSQNLLIISEATSDTWEVTASFLNITSGEGHADAAGPIIRTVSEQGRPLLVQIHQQYVAWLVWIPASQRREVEVWDWHTSRLVWRRAFRPQVSFTFLDTSHILVTSGRQEVLEVFCLDGPAYVLGEIIEPFLTLELPLGAFRCSVHHDERSRIHSSSPPPDAPFIPDPMLSVVAVRFAIYATDLSNALLLVPGSTFRAQIQAARGSDESHHRVFWHEWGPKGGLLLNLSGPEVIPRAVFSPCGSRFPMLIRDKWRAGSAQIVIFDLNPWAARAAQSNPKSSGSLTVMKDASSFRFRTLRASIPHVAYQGPRLSFPKEHKPTYVNMNHDGFTVLHEWKPPYQERLGFGYQTFFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K527</accession>
    <name>A0A4V2K527_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_975792</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K527"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="210" mass="23281" checksum="AD2715B3F8D5729C" modified="2019-07-31" version="1">MVSKKSRKVKAYGEKGAILDDFRQKHRPPTSLRQAIGDDNEVMNVCPVYGLPFSHEPPQTLSEKAKEAYKRRKERERKPKMAQAEGLPNDVGSDGESGRWVYWSQDEQERRSDEPTRHPIAGSPTSLEMGHASMASRPMFSEPVNASSRFAIGLYGTLYDPPVIPQPPSPGIGHATMAFSPSCLLLSSLPKAGYQLVWTFNAVRLAVAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6W7</accession>
    <name>A0A4V2K6W7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_887129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6W7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="24"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="232"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="638" mass="72026" checksum="0411AF38E1A36DB2" modified="2019-07-31" version="1">MWLLSTKRAELHFFNGPEQVPGGYAVLSHVWDQNEQSFQELRALQERCQGHKNPRDLASEKVRQCCWIAEIHGYKWIWNDTCCIDKTSSAELSEAINSMFRYYSLAKICYAYLRDVPASPDPNQFQSDFCRSKWHTRGWTLQELLASKFVIFLTRYWQPFGSKLELAHLLEIATGIPYSVLTLQRGLGDVSIAQRMSWMAKRSTTRAEDAAYCLLGVFGIALPTLYGEGGNQAFQRLQEEIMRRYPDTSLFAWGSEWGNEPIYEVNLSHEHDTDDMYLFARSPNAFRDCDKEFTPLGSQTSPIAQVSLSSQSPGSRNPNELAGNPTFSLTPHGLLSRIPGIEKGDLTIGVLGFSQSISQPELGLLLTLCPRSTDLLRPLYDVGMAGSAYLDEHGLVRTKWVRLVPLGLVSEESLTLFGERVSAQWKEIYLSHHPPPDMGSASLQQGPPVLLSYGYQAPFRFLENHVEDFIRTTPNLRLDFVRNPSEFPWDGIPPVMFVFTASSYDWTLTFILRMGRCHHRRVWVPAGSSTTRGWHARWARVDFCPLASPNAPPYTPEFFAPPGSEGERSHDCGIDHVAGWGYPTKDFVYSGQQVTLHLERCPINPAGTYVVNIFATLQGMFHRPPKPQIPQVPLPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K707</accession>
    <name>A0A4V2K707_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_97764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K707"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="84" mass="8776" checksum="05716E70741A0C69" modified="2019-07-31" version="1">MPAQHCIKATPVTQLEPPPIGQSTPHFAALVPLPNLNAPSAQSTPRVPAAQLLFPPHPRFSSPLLSNVPHPASSFGSPSPVQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7B8</accession>
    <name>A0A4V2K7B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mo25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_825561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7B8"/>
    <dbReference type="STRING" id="114155.A0A4V2K7B8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="321" mass="37700" checksum="49FB4486C1513A98" modified="2019-07-31" version="1">MNFFKTKPRTPPDLVRGLRDALSKLEAEPPGDVRRKNLQQIKAILYGDGDPLPELVAQLAQETYSTDLLLYLLQNIKKLEFESRKDVVQIFNNLLRRQIGSRFPTVEYLNSKPEVLFAAFRGYEEEEIALNTGMVLREMLRHEPLAKTLLYSEQFYKFPHYIESTTFGISCDAYTNLKETLTRHKTMVAEYLDKNYDRFFSSFTTLILSNNYVTKRQSLKLLGEILLDRANFNVMTRYIASEANLKMMMNLLRDKSKNIQFEAFHVFKVFVANPKKPPQIEGILRRNKDKLLKFLKDFHNDKEDEQFTDEKQFLIVQIQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7V3</accession>
    <name>A0A4V2K7V3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_978000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7V3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="8804" checksum="A6E74493AC613AB1" modified="2019-07-31" version="1">MFSITLPVNAPLTNRIPAPQSIRDNGEVVEDSERLSETSFQWAGYGAPAGSTLIIYVTDTAGDGASTAPVVVSPSSDSSCLDPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8L5</accession>
    <name>A0A4V2K8L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_957651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8L5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="490" mass="54895" checksum="44CE96FE39BAF81E" modified="2019-07-31" version="1">MISAEANQISAIHQVKPLCCRTFRNTYEHQVGAAGRDPYWIPIMEAESFSQNSPIHIDIDVQFAILEHLDESHTKDTIASCAMLNHEWLSVFRPALFRSITVKPHADKRLSSFIDFLLSHPDVAAYIQELVLSGEAAQSLTDRYITVREYQAVMATLSHLRKLRLVSLVIGNQFLSATPHPEMEALPHGPVRPLQSLHIDDCDSIGSSESPTWTHDPRPLLDILCASLSINNLTIDNTCGSNLYDKQSTHHILSALIEPQHRPQSPTVHTLVLNSIRPATAAILHAYLAYTGSLEGPLTTLRVGRFGSSKSFPLFYFPMLWDTRAHLTELHLCAADVTCDLNPGLYQRTIDHFASLVALQTLVFWVCSSFGRPGSQLTMCTPLLKPPNLRTLSFKLDPGDALAIEFLSRMARLPSPQASLLWGELDEALHGIKTLRAAEFAFYNKGQHTPAAGEDHFEPFRRTFERCFPMTLERGILRVRHMPGQSYGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K956</accession>
    <name>A0A4V2K956_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_918576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K956"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16168" checksum="14B80460269AC1D4" modified="2019-07-31" version="1" fragment="single">MFEVPERFLKCVFFLSSSLVFLHVLCMMGFHFLYSAFHTVWEVSQGALVDLLVPSYPIYHPVRCVAALFTHGCGTGDLLLTFDSQPNDLCPLAAGIDYGCVPAHSFVGCDGVICPVITVGLVAIGSSVCHLIRATCKTSSIISPKRLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MK34</accession>
    <name>A0A4Q9MK34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">coproporphyrinogen oxidase</fullName>
            <ecNumber evidence="4">1.3.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_830417</name>
        <name evidence="7" type="ORF">BD311DRAFT_667546</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aerobic coproporphyrinogen-III oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.3" evidence="4"/>
    <dbReference type="EMBL" id="ML143446">
        <property type="protein sequence ID" value="TBU26421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MK34"/>
    <dbReference type="STRING" id="114155.A0A4Q9MK34"/>
    <dbReference type="OMA" id="PLVAWKY"/>
    <dbReference type="OrthoDB" id="15318at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00322"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1500.10">
        <property type="entry name" value="Coproporphyrinogen III oxidase, aerobic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001260">
        <property type="entry name" value="Coprogen_oxidase_aer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036406">
        <property type="entry name" value="Coprogen_oxidase_aer_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003727">
        <property type="entry name" value="PRK05330.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755">
        <property type="entry name" value="COPROPORPHYRINOGEN III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10755:SF0">
        <property type="entry name" value="OXYGEN-DEPENDENT COPROPORPHYRINOGEN-III OXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01218">
        <property type="entry name" value="Coprogen_oxidas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000166">
        <property type="entry name" value="Coproporphyri_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00073">
        <property type="entry name" value="COPRGNOXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102886">
        <property type="entry name" value="Coproporphyrinogen III oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU26421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="314" mass="35100" checksum="F3A7B3DDF239D953" modified="2019-07-31" version="1">MRERMTFYIENLQTTIVAALEAADPTAPAFKRRAWDRAQGGRGVSCTFSAPDHPGSLLEKAGVNISMIHGQLPPAAIANMATEHALAACTGSMGILPFSAGGLSLVIHPRNPSVPTLVAWWFGGITDLTPCYLFEEDVVHFHSTLKAACDAYGPELYPAFKKSCDSYLFIPHRGEHRGVGGIRFDDLCDEPLPLLTDASAPRPRTPDEIFAFVKSCADAFLPSYMPILERRRDTPVDERKRRWQLIRRGRYVEFNLVYDRGTKFGLSTPGVQVENVLMSLPETARWEYMSEIGTEEGSEEFKMLEVFKSPRQWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MUS7</accession>
    <name>A0A4Q9MUS7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_924058</name>
        <name evidence="8" type="ORF">BD311DRAFT_753578</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143402">
        <property type="protein sequence ID" value="TBU30978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MUS7"/>
    <dbReference type="STRING" id="114155.A0A4Q9MUS7"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="32"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU30978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="68" mass="7415" checksum="A13B32C02EBA815C" modified="2019-07-31" version="1">MSSTQVQATSGSNSDGEREGAKPKVPRRTPMACQFCRGRKLKCDGRPTCANCQRRSIPCIYVPVAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N1W6</accession>
    <name>A0A4Q9N1W6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_819493</name>
        <name evidence="5" type="ORF">BD311DRAFT_479409</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N1W6"/>
    <dbReference type="STRING" id="114155.A0A4Q9N1W6"/>
    <dbReference type="OrthoDB" id="2720823at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="302" mass="34111" checksum="4EE94D82708811E3" modified="2019-07-31" version="1">MSLTHRSSWDLPLDSSMYAPDEEEKAFMKATTGIQDDEELKAHILAVQAKAWTIYKYPCIRQFDFMRLKIARMPAYNQFLELGKQRKDAIFLDVGCGFGNDTRQAILDGWPIERVIAADLSPQMWNVGHELFRSTPDTFPVPFVQGDILDPAYLAVAPILPTSSTPILDPLPPLSEVKTLNELHGRLSAMFASAFFHLFEFDGQEQVARKLAGLLSPLPGSMIFGSHTTMAEKGRWEIGDAKSDCHSPETWTELWEGIFAEAGVKVEVKTRLRKHRGGLTFYGIYSGSTKERFYMDWSVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N7W0</accession>
    <name>A0A4Q9N7W0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_944971</name>
        <name evidence="3" type="ORF">BD311DRAFT_745943</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N7W0"/>
    <dbReference type="STRING" id="114155.A0A4Q9N7W0"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08267">
        <property type="entry name" value="MDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052733">
        <property type="entry name" value="Chloroplast_QOR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44013:SF1">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C16A3.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="35"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU35311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="360" mass="38477" checksum="B40F55AA6CC2F8F2" modified="2019-07-31" version="1">MSAGQAQATPAAPTTEASSKSIPATQKSWRVTGSGDIDKVLKFGDVPVPKLKKGDILVKVQAAALNPVGHKVLKLLPGFIARRAKAHEFEIAGVVVDANGTEFKEGDEIFGAIPVLSVFQNGYGALAQYTAVSAQQAILRPKNVTPTQAAGLSIAGLTAYQGLIDIAKLEAGQSVFINGGSTAVGSFAIQLAKAKGAHVAVSASGKNEQYVRNLGADEFFDYTKAPLHEQLLAADPNPKYHVFLEAVGMNDPTLFVESEKYLAPGGVFLDVGPQGGYLKFFWKVFLQPSWLGGTKRKWKLIALDVKKEYLVAFAKLVEEGKVKPLVDSVFSFEDTLKAYERIKTSRATGKVVVKVDPTAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAE3</accession>
    <name>A0A4Q9NAE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_831796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145243">
        <property type="protein sequence ID" value="TBU52630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAE3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5812" checksum="45F7A87D98ECA35F" modified="2019-07-31" version="1" fragment="single">VNTKVDVPALDIELRQLLDAIELALDASGRPLRVLDGEIPRSDLLSPELPLGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NAG0</accession>
    <name>A0A4Q9NAG0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NAG0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="64" mass="7383" checksum="BEEBF4705113582A" modified="2019-07-31" version="1">MLSRGCVLSKWPHILRPHWNSAKEAARVALCSHRRKAELSQSRRRSQHGLLDWGGNPYPHDISQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBH3</accession>
    <name>A0A4Q9NBH3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_932750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145161">
        <property type="protein sequence ID" value="TBU55903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="388" mass="42436" checksum="9932C9486E83C58C" modified="2019-07-31" version="1">MSATATTTAGLSAASAKRLRTELTTLAEHRVFPVVVETALFAIFTIIILTSTYILFKRGIRKSRPNMLMLSATLAMYAISTLDWAIDIRLLWNDLHTLTLTGLPVSHPPFGVSDPALLVLQGITSVICIILGDAVVCWRVSVVWGSDRRVVAGALFWVLGSIGVFTAWSAMFVGFYYDHLPAPVEVLVDHSTIVNALAFSWSAATNVWATAMVAYKAWLQRRDLRRHLGSTGLAVHDVLMLLVDLGIIYTVFMLLNVIVLAPSLNGGKFFSYVTLFMQQITGMYPTALIVLVALQKSHLDHQFTYPPTTHDRSSEIESLPFTVKAHHPKDAEFGDTTDTYASASTGYGYERDAGTTARVMALHAPTDTSEPIWEIGKDSSAEGVALAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBZ6</accession>
    <name>A0A4Q9NBZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_840567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBZ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="188" mass="20453" checksum="878AB430D0777309" modified="2019-07-31" version="1">MPLFGKSNNNWSENPEVREVEKRVAKETHEDQKNLDHALGDLSKADNTHNKSIKSVDKAHHNLDKSVQKEHKTAQALDKATHRHDVAVTNAKSAEKTEQMSREYATRIEQDLEEKRQRVEDLRQQKAHNDQIRETRLSEIHAREAAIADTRSSFDAGAASAGVEGPGIQAAASGGPGAPAGAAGAPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NE20</accession>
    <name>A0A4Q9NE20_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1041696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NE20"/>
    <dbReference type="OMA" id="SWHSEDT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF4">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14169" checksum="BB238DE26199B147" modified="2019-07-31" version="1">MVRVIDWSEDTVKLAAVLAEHGVDLDVSSGGNSPDQQIQSVPGYQVPFAAAVKKVHGDKILVSTVSAIYKGKLAQSILDEGRADVIFVGRMFQKNPGLVWSLADDLGVDIRQPGQIELGFKGRPQPVHKNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEW9</accession>
    <name>A0A4Q9NEW9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_930424</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU57008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEW9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NEW9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="546"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU57008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="840" mass="95088" checksum="296D348E511240B0" modified="2019-07-31" version="1">MGDEYPTLFRSEQMSLVQLIVPTEVAHDTIAELGELGNVQFKDLNPNVNPFQRSFVGEIRRIDEMARRVRFFASQIEKEKEAVPIRPLYDSAPLVTVGPRAAQTIDELDVKLAEHEARLTQMNESYQLLSERLRELVEARHVLRETAVFFERAAVRESEVRQSLDDSSAPLLQHDDREQQYSSVGDVQLDLEFIAGTIDRTRLSTFERVLWRILRGNLYMNYIDIQEPFVDPATGAETRKNVFIIFAHGDVLLAKIRKIAESMGATLYPIDVNADKRADSMREVTGRLEDLQIVLYNTGANRRAELQTIGESLASWQDVVAKEKLIYETLNLLNYDVRRKTLIAEGWCPTRDIAQIQLALRHATEESGTNVPPILHELRTNRTPPTFNRTNKFTEGFQTIMDAYGIATYQEVNPGLFAVITFPFLFAVMFGDIGHGFIIFIAALAMILLERKLAKADLGEIFGTFFFGRYIILLMGAFSIYTGLLYNDIFSKSLHLFHSGWEWPEPHGNESVVAYSNGHTYPFGLDPGWHGAENQLLFTNSYKMKMSIVLGVIHMTFAVCLQVPNHIRFKRFSDIWTNFIPQMIFLQSIFGYLVVCIIYKWTVDWSKASTQPPSLLNMLIGMVLNPGTIDPGTQLYAGQSTVQVILLLMAGVCVPWLLITKPYLQYKEMQQIQGQGYIGLLGADEAPRHAEDVDLEGEEEGNGRAIVEVNDEEHEQHDFSEVVVHQVIHTIEFCLGCVSHTASYLRLWALSLAHAQLSEVLWDMTIANVLDMTGLVGIIAIVVVGAMWLVMTIGILCIMEGLSAFLHALRLHWVEANSKHYEAGGYQFVPLSFARLNEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NF28</accession>
    <name>A0A4Q9NF28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_819481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NF28"/>
    <dbReference type="STRING" id="114155.A0A4Q9NF28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="463" mass="49389" checksum="3ED410DDF555FD5F" modified="2019-07-31" version="1">MRGARDRSGERSRDSRKEKEREKEKERITHPRRVGSPLPTARARQSTSAVAVAAVPMEKSSSAHSANSKHSGSREHHSGHPRSGAEASRTKRNKHGSFDFERPVSAGAGPASGSSGVMSIKTALQSMGIGEQERQLALQRSHSARAVPRRPREEPVEHGFAPASLPSTRGVLDKGKKPATDVHFANPPSRRSTDRSGSAGQHSQPASHSSQSHPHSRGHGGHHPPQPASTSSHGHRRDPVPASPMSTASGDSSGHNRDGSWGRSAGKRVGRASHGPFKFEPAVPPIPGSPADNERRSAARSAPRAASPSPLTVSEAMSHSKQARLAGKGRSLDLGLGLTWAPSRVREEAVLRVGGPRTGMSATTSSAARARSRWRGADEEGRLTAGAASDVAEAFKEALGDAAYGTFKNYVHRFDANAIPLDGPYGLLVHVERLLDNSPGVDQLRKRVLLERFLRVVQNSEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGG1</accession>
    <name>A0A4Q9NGG1_9APHY</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_817250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGG1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12116" checksum="42EFDAF12D971FAC" modified="2019-07-31" version="1">MSVSVSARTVRREEAKSGLAARRAVLLLLRVDSTCEAALGAWERFAASLENDAPHEHRRALPPPSLGRYFGGSIEMAYPPPRLAVALVARYWVWAWTWTCAPGRHEGTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKD2</accession>
    <name>A0A4Q9NKD2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_708093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKD2"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="134"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="384"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="724"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="781" mass="89493" checksum="3E42A474AA6450BB" modified="2019-07-31" version="1">MDQLKELTVQIPFGKFLDAFCVQPHPHSPRYRRKSQKCTTRAFHQAVGRLKEGPGSYSGRMADLMQKFKLWPRHKLTIQSHDAAAFEWALIEPLQDARPGWASPRVLFRFCEIDPRHEYLPSGYNPSWESAEAGSTRKEFWKDICTQVQRHFALQQLNALYVVLVQDNSTLRVTRWDRSGVVATEWVDYGNKPDLLADLFWRMSMLTDEQLGFDPTATAVLPGSPEHVLMDRMAQPHADDLDTTEGVVIEGDATDPNRVFKFARDAFRRTLSLSPFLARGRPRWKLSVPTTDSQPREFLVGAPLTFEKGEVFDWRNSRGYIAVDCQTKDFVFLKDTWRELGDQANAESEGDCLTRLNQAGVPYVPTLLCYADLRYTVTPEYHDHQDREGPEWRLHHRIVVREFCLSLSKVVNGRQLVSVVKDCVSAHAGAATSAGVLHGDISFGNLMVVPKLRPMSAGKHVVRCEGILIDWENFRPLRVGRPALRMTWQFASVSYIHDTTAPLEIADELESFFYVLIYAAVRLLHSSCSDVESFLAGFFDRDYIDGVGWAVSTWKRYLLDRMVLVGPPSGEKLFFYGDPADSTHERTVTPLNALLFDWLKWCNSRFYARFSVNGRLVLLDDRHFIPMDNPPVFQYRRLISKSQKRAHAPKFDNHNAVLELLEAKLREEWPRFDLAGDRCESETYSAPTPVEHHSIEPHVLVKGEEEEVALMLEEAAKPREAVKRKPAAKKAQKRARKPLGVEEGRRVENKAATRRSKRLMNEPPSPIRDAIERPAKRQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NM08</accession>
    <name>A0A4Q9NM08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_699633</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9NM08"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1199"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1731"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1199"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1731"/>
            <end position="1745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU62716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1779" mass="200965" checksum="B0D8433699713AC2" modified="2019-07-31" version="1">MDLDDFDAAIAQLPLKEEPTLSTQSAKAAVNYLDSQWYSLVNRRGRWMDLIGDYAGSEPFIVDGEALIAMVLEDPLLALGRTHDISFQCLHAVYTLECMIKQISMRSDSFDIVFWHERRFLTLLYGENDYVTSSRSLARTILFNHLASLRLSVHTFTDLLDPAWLAYQRLRKPMFVMTSDGGAVVDSSPIAAAERILLQRVFLYSLLTQGVSVAMLRGAEYRDSKIMSFVYEQGLDSNPKSRFKKTFWLAVEIATSSLIAHENCARSEVPIHPLERRIESEASDNPALLLLRGVSRSRNLQRKHFPALLQVFVAHMLFLPHLDLRERAIPDIILPSELVGLLTRDFLPTVFLALEKIASVSDLDGRIFASLLDSILRDHTTPLQTLIGCDLSSVLVKLWVAHQLPSPDYDALRRQFPASIVVQDDSETESPPLSLLPFHHRLFDEELAAVNVEAEALSDDDEDDEESAAHLEFNTVFSDTQHWHNHKRAILPPYLGGGNSMAPLNEWQKKRQLRSEQRFMSKLQWHAETLTGALGTPLQQMVIPSVAKRKSRPTNSSRIEESKPTTPTRSGSGKKGKETLSSADKIHLAYWAQKQAKEDGSNVAWWQEQLAVIENSSSSAASSSSKITALEHLMRNKRTYHGWLSVESRLYRIHLEFCRWLEVPDHESASVRDRFTVSIMCMVKDLYESEDLFPTAAAKLAACLICLGLNDYIQAFESAATVSAEDRKLHFSFVKLVKSKGVWHPVHKWMRITEDPVVWQLRLFGDFMDRSMDSARDPRVSFKADAWQRKVLDCLDQNESVLVVAPTSAGKTFISFYAMEKLLRSSNDDIVVYVAPTKALVSQIAAEVFARFSKDLGGRAFWAIHTRDYRMHNPQNCQILVTVPEILATMLLSPPLARSWTPRIKRIILDEIHTIGQQEGGAVWEQIILLAPCPLLGLSATIGEPEKFNVWLASVQEAHGFKHTFIQHPHRYSHLRKFTYLIEPKEKPAEFQGLQEYRKSDRLRFIHPISMLSFGARHLPPDFSLEAGDCLSLYHALESVRDRLHFNVGSLDPTPFFADLKGVLLKQRDILRYEAVLTGHVSELIESTDPLDQDSVLNQVIRHVSDPVIVKVNQRFIPDADAFFRNLIGLVSDLHINGDLPALLFHFDRKVCEKMAETILEVLAGAEAKWRETSPEWRRKITQWKFWVSKSKERERQAERLKKVKKEKDEANATPKTQPEQGWEASFNPDDPSPQFSFAGMSPAFTKEDLDDEIRSLARWRSAPEWALKCLQRGIGVHHSGMNKHYRTLVESLYRAGYLRVVIATGTLALGINAPTKTSVFCGDSPFLTALMYRQCAGRAGRRGFDLLGKIVFYGLPMDRCQRLVLSKLPSLGGNFPLTSTMVLRLFNLLQGSNDAPVARNAIKSLLHLPHVSFVSDVGREQILHHIRFSIDYLRRSGLLDERGNPINLFGVAAYLYYTEPSNLALVALLRHGVLHRICNQRSLIRAKRDLMILLSHLFGRRYLPHTYASREFLQTIVKKSPSMVVLPPLSKDARSVLLEHENHIKGIFTGYALAYVSRHAEELGRDLQLPFSKRAICPVSSTAPSAPFTDKLRSTAIASVARSPFVATSGHGDNFRSVKELCDTSRQALYLNEYAIPSMCQFTAIPGEDSKEFALNAYLLDFYIHRQTAALNAANGLRDGEMWYVLQDFSLTLKSIRGGLFQLLQKASDSGSGEDDAVSEVDSGFANMTRAERDPDLDGSEHGSVKPPAGVSDRDWKVYEVLDALTAEFHEKFHKIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRK2</accession>
    <name>A0A4Q9NRK2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_995450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRK2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033909" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="81"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="600" mass="63640" checksum="1911084B7C9E5CD3" modified="2019-07-31" version="1">MFSRLSSLLQFTVLLGTATASPTHGTSTVVRPVTPTTVSVSASSDFSSLPSSLSAASSSSTLASTPSPSTPLATAALDKAQVIGIVNGPVTTFNGIPFAEPPVGDLRFRFPVPVHGYNGTINATQPATQCIQLEPQIRVDMPPQMLQDVEVYSTSVLSSSSAPQSEDCLNINVQIPTGTKPGEKLPVVAFIFGGGFVVGSNAQMPGDAVVARSVEMGQPVIYAAMNYRLHAFGFLGGKEVKDAGVGNLGLHDQREALRWIQKNIAAFGGDPEKVTLWGPSSGAISSTLQMVTNGGNTEGLFRGSVMSAGSTIPTGDIEELQPIYDRVVDAAGCNVADDTLECLRQLPAANLTAAAGTIPSLFGYPGLATPWAPRADGKFLTAPPEHLHLVLANQVADIPFISGDALDEGTIFATGSFNITTEQQFRDYVHQFFFPHVPSAALLEPLFNLYPNDPAAGSPFLTGDANQLAPMYKRMAAFQGDMIFQAPRRFILDQRSSKQPTWSYISERCAVPRLGFAHGTDIASAISGQELADYIIQFAATQDPNGKNGTASERTIYWPKYDTAKRQVLSVLNDSLAIGNDTLRLEPIASLTALSLAFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NU73</accession>
    <name>A0A4Q9NU73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_401963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NU73"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="239" mass="26272" checksum="0892A598B642B4E6" modified="2019-07-31" version="1">MPLFRASLPLSTDVSRPCFPPPSLAASCAAPSPPLPSCEVCLQCPKQKPPRHRVGDINQVSPIAKGHPPRRACFSLHSSLFRWTRVARVHWQSRARCARCVTEPLAAAAQLPVLRALLSPRIGSRSAFPAAALPPLCQFLPGRCSSLPRGEPYSSIFLSWFLSLTSGWTSIRRLRGTPCLVERRTVDLAARWLSVYHRSRASLMDACCVSHLLAILFTPSSSVPYWQPGLLDYAFLGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVD1</accession>
    <name>A0A4Q9NVD1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_805047</name>
        <name evidence="2" type="ORF">BD311DRAFT_777698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143415">
        <property type="protein sequence ID" value="TBU29111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVD1"/>
    <dbReference type="OrthoDB" id="2744543at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="199" mass="22436" checksum="CD8F4A311A860B74" modified="2019-07-31" version="1">MRNDSLTRYIRASDFSPTVYNLREYIGGTIVHIQAIRQRRDLTIDHGDAICSFRLPGDKDSKLPSLIPSLLRKTQPKESIKRSKEVRSAIDTLVKDNLGDRYADMIEITHLGTSPEKQGLGYGTALVKVVTDIADGQGLAVTLITTDAYRFYEFVGFELVAEKLVGVDNPTWDGAPVPIRLMLREPHRPGSWEKQMRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVS9</accession>
    <name>A0A4Q9NVS9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal nucleophile aminohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_528314</name>
        <name evidence="3" type="ORF">BD311DRAFT_745989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVS9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NVS9"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000060">
        <property type="entry name" value="Related to DUG3-probable glutamine amidotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="2"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU35334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="38359" checksum="DF0CC2B2D1241A0B" modified="2019-07-31" version="1">MCRFVIYKGTEPVQLSHLLTRPCHSIINQAFDSRLRLDHRRPINGDGFGVGWYDSVYDEELGVQPCIFTSVTPAWNNVNLVRLAEKIKSPLVFAHVRATTAGTLSLDNCHPWSYGKLMWMHNGGISDFHKLKRKLLQSVRDDVFNWVTGNTDSQWAFALFLSKLPNPSAESFTPAVLQRAMLDTIAHINSLLEEYDITEPSLMNFCVTDGETVVATRYISSRTDEAASLWFSSGSTFSEYAEGGHYKMSKTDKRENLILIASEPLTFEKADWMEIRTNHMVVITPKMNLLQIPIVDKFYVKPSDPAAPHRDVEFAAAKGFLSPGLRRDTISRPMDAATSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NX29</accession>
    <name>A0A4Q9NX29_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_626904</name>
        <name evidence="2" type="ORF">BD311DRAFT_154346</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143548">
        <property type="protein sequence ID" value="TBU22306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NX29"/>
    <dbReference type="STRING" id="114155.A0A4Q9NX29"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="11"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU22306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="281" mass="31566" checksum="B8239659CB52D686" modified="2019-07-31" version="1">MSSCLFHFRDADLTLRSGSSHGEYHGRQKTVDFHIHRCVLSAGSPFFEAMLSLPQPPNTGNEALPVVPFTESAAVLEILLAYIYPTPDPIVNTLDELAPALDAARKYDLAVAIDGLRRRLVDPVFLKMYPLRVYAIASRFELDEEAAVAAKATLSTGLHGLPLHEDLKSMTAYAYHRLFLLHERHARDAIALLSLPDEIKCMQCNGRRDRMHEPPLWWVEWKERAREELRLRPTAETICSLGFLQQAAQAGGCERCAGCILASSWFFDQLRRDIDALPVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NY45</accession>
    <name>A0A4Q9NY45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_807380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NY45"/>
    <dbReference type="STRING" id="114155.A0A4Q9NY45"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043938330" evidence="8">
        <location>
            <begin position="19"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="347" mass="36829" checksum="C58FCF79835E803B" modified="2019-07-31" version="1">MFSSLFVALALTATGVFGAPSSADTVAALKAAPAQVDRIKILDQDSDFVFNFFNATPVKGAGGELLSATVSDFPVLVNNGLAMTIGLIGPCGMNTPHSHPRGMEMLYLVNGTITTGMIAENGARFVFNTLQAGEAQVFLQGSIHYQQNELCDPILFVAALNNEDPGVESTAQRYFGLPPDVVAASLGDLGVEYVAGIEEMIPDNIALGRQECLDRCGIKRQGQPTTQRQPRNANNALPSSVATTWPSTMTKQYQPSSTPTQSTKTGNVLGALAESDSTVTANGGTSNSVLIALAAVVGAMAIGYIAIGVFWLVRRRRSAAKEANRFYVRPEMSGRSLVPTEEKYDTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NY83</accession>
    <name>A0A4Q9NY83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyn1</name>
        <name evidence="4" type="ORF">BD310DRAFT_917639</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NY83"/>
    <dbReference type="STRING" id="114155.A0A4Q9NY83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002773">
        <property type="entry name" value="PRK02866.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18121" checksum="537FC61493DC028B" modified="2019-07-31" version="1">MSQQTLKVNSNAEPYADLPSICAQLLEAKAKKGVTFDAIGKAIGHDEAWVAALFYGQAKATNEELAKLGDFLDIPSSSLVAEIGENWFPRRGLGPIPPQDPLLYRLFEGVLVYGTPIKALIHEKFGDGIMSMIDCKVKVDRKPDPKGDRVVLTFDGKFLPYLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYF5</accession>
    <name>A0A4Q9NYF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uricase</fullName>
            <ecNumber evidence="5">1.7.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_876998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>urate + O2 + H2O = 5-hydroxyisourate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:21368"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17775"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="EC" id="1.7.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the uricase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="5"/>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYF5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NYF5"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="291" mass="31784" checksum="0BAD60862A46D459" modified="2019-07-31" version="1">MYDNVWEPHSYLSHAHHGKDKVRILPVFRDGAWHSIVECNVTVLVEGDIDISYTQADNFVVVATGSRAARGTDVAKTSPHVLVPKRFALHLRSPILRWQHVPTSQGPSQTPKEHSHAFYRDGDERRTVEVKIDASAGKDKIVTRVTSGLKDLLVIKTTGSAFESFVRDEYTAVVEFTTVSSRPQSVSPTYTSAPRVSVPKPADGQGKVFDAPFSGDTAKGTPWDVEESASVLQATLYKMGQRIIAENSHITSIPVDLKYIGIDSTSPPNAEVSLPVAHPSGLMIAATVCRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P026</accession>
    <name>A0A4Q9P026_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_917676</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P026"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="137" mass="14794" checksum="817E71AEF2EAC67D" modified="2019-07-31" version="1">MGVVAKMPATAHIPVVFVFHPFLCQTDTTPAWSEVGNRWRSVTTTAHTLPRTSRIADALEDHRPFGALLFGVVVALMGAAACGTTSLDWGRAYHDGPETVAHTPTSSVTRSWTRLRIVARLGPYSSASRKANVHVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P170</accession>
    <name>A0A4Q9P170_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein-tyrosine phosphatase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_916906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P170"/>
    <dbReference type="STRING" id="114155.A0A4Q9P170"/>
    <dbReference type="OMA" id="PLLFHCF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126:SF1">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31126">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="278" mass="31013" checksum="329C2CF7C738CCB3" modified="2019-07-31" version="1">MDLEPLDPADVSDQLSKPPFVSIPGVVNVRDLGSYPTDQPGFMTRPRMVYRSGEISFITPEGITELRDILGISKVYDLRSDTEMQKYGTPIPEMEGVEVIHVPVFKREDYSPEAMARRFELYASGKTEAFMQLYSQILDHAGPAFGVVLRHIRDKPEQGCLFHCTAGKDRTGVLAALLLKLAGVDDENIARDYALTRVGREPAREMVMRRLALVPFFASNTEGALNMLSSRHETMIAFLRMLHDRYGGAEAYVQNVVGLSADDIATIKRNFLAPVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2Z3</accession>
    <name>A0A4Q9P2Z3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1024791</name>
        <name evidence="3" type="ORF">BD311DRAFT_811746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU22134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2Z3"/>
    <dbReference type="OMA" id="DWAHKLH"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="83"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU22134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU63323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="333" mass="36590" checksum="A7D8BB0C6305B1AA" modified="2019-07-31" version="1">MQPSSGFQWFLLVCPAVVVLAYFVTIFPHTPSTLYVHPSLATLDKAAPSWSIYPDNYYEGGAYVKLPQGSTRYWLIGPEDGKRVVLIHGLSVPSIIWRDVAPNLAKNGYRVLLYDLYGRGYSDAPHTTYDANLYTTQLALLLQYVGWNKANIVGVSMGGGIAAAFSAQFPHLVNDKVVLIASAGLMDSSDMSRTTKFLSSPLMQVVASSSPFRLYLQYLADQKAPSDPIAELVRIQSAYLPGYNAALASSMRDGPLRNLAPQFTALGRHSRKTNGRVLVIWGTADKVVPYRYAAKVQTYIPHAELVTIEGGPHDITISHPDEVSRALLHFLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P332</accession>
    <name>A0A4Q9P332_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_928375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P332"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="521" mass="58872" checksum="B785417B43613D6C" modified="2019-07-31" version="1">MQMAPHQNTKAVLNLDVLYHIMSSATMPTIAAMMRVSHALYRDGAKVILPRGVCLDDSKTVSSFVQFMMAEDGIRRHYLHKLEIFFNKLSSQDAHLLAQAIRSVPDLRSLKIVYAEWVLKHQRLLETFIGLEGLESIDLRSCGEHACRFLRESRSRFVSATIHFPEAEECSIPVELPDLTWKPILLLENSMSTLQVLHCSAWEADDGIEVHEEYVYPHVQELVMDDIWFPVTSAYVYSYPNLTCLRTETIHHQISDDETTSEAQRASNLAYQLRHGSWTKLQEIHAPFIDVYLLGLTCCVPFLDVMDVGGSDISVRLSEVLSYLQPTRLVLSTKDNLLRTRDGIAQVFRSQGASKLKELELTMASFCLGSDGAVVRDALDDLFVALGSLRLTSFKLTWDSDADHRRIGVLLKPGYHSDHKERAEIQREESADGEKQLPSSRVPVTPLEIFLLHVDVNELVAKIHRALPTLQTIEVAVRNVPRRNNGVITFSPAEMFDKYAALEHGLRTTEYTDTAEASGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3D4</accession>
    <name>A0A4Q9P3D4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3D4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="172" mass="19610" checksum="92D9E4CE90ED3C9C" modified="2019-07-31" version="1">MYKAATVILRNNASQQFATDNTTRTETTVKNGRGDEGRGRKMEIRRAVGRMRRRDDGTDDTEDPTGRRWTSDGDSELDVREQTRTGRAPLTPRSARNRIHGSVRSSSTPERRAGSARDTRTGRRPQQRQHVRQRGATYQDVWDDVSESERRGMQGRGQGGRMRDAKMMCGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P523</accession>
    <name>A0A4Q9P523_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_977825</name>
        <name evidence="2" type="ORF">BD311DRAFT_661794</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143415">
        <property type="protein sequence ID" value="TBU29205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P523"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13678" checksum="C6EE3614E7FDE17F" modified="2019-07-31" version="1">MPTCLPFSFLKRRKSQSPKVKIPQGSIERKPGVSIVVENGERSRKTVVGTHIASSIFAFTSFVFAFAFELLVIFLVCLFISFLLGAVSLYFSSSNGAFAISWCLSFTPVIASYSPAIVILSSQAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8Y0</accession>
    <name>A0A4Q9P8Y0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_983021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145445">
        <property type="protein sequence ID" value="TBU51014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8Y0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10549" checksum="A7B4F6F10BCAC57B" modified="2019-07-31" version="1">MAKRTTGKTKKIKISEIRNVPLPPAAASAKNKVPRGNQAMIIPEIPSTRKRAQAEQDEGPRKKKPKAVQDGSDSSKAQTNGDQRHDRPHPGIPRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P988</accession>
    <name>A0A4Q9P988_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_382503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145366">
        <property type="protein sequence ID" value="TBU51190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P988"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="163" mass="18111" checksum="BF2C83E38CDB4702" modified="2019-07-31" version="1">MRAQSADRVESSPSHLRSFPALPVHINADCLYSHRNRPLPACCDPPSRAIYSTSTIPRHAQHLGRSSSLSPDLWTPLPPALQLLRFRPLCSCPPSCVHRRFLSGMLVGQCLHGLREHSVYSRHLRVSCTSQTSCPGISAAAVLAVLPRPPDQHYGHVLRKRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9C8</accession>
    <name>A0A4Q9P9C8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA pseudouridine synthase D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_807534</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9C8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9C8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="50"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="627"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="117"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="792"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="824" mass="89763" checksum="C67E84D4DFDA7A1A" modified="2019-07-31" version="1">MQQIMETDVGISEYIGFDVPKIEGIIKQRFTDFLVFEVDQDSQVIHLKSLGMPSSSKKGGAATATGDATPAEPTGVATSEQKGAETLAAPVERPVEASTTEPAHESAEPTAEGEAKAEDEEPLQDDEPWPERFTNSLKPFLSEEVIVRVRELYLEGPEPPFVSDSGWAGRQAKVAGGTGTVAGETGKLAGGTGDAAEASSTHEPAEESESKGKGKRGRDRGRGGRGGRGGRGGGRGGRPGAKEDHRKVLSDPIASKETRTGLHQIIRDLFGGKLDTETDTTASPSDEGSRIAIKWSKRGGGGRGGRGGNRGGGRGGRTEVAAKGERGNYPPYIHFTLQKTNRDTQDALAHLSRTLHCNVKDLSVAGTKDKRGVTVQRVSLRRGNKTVEDVWKMANGLNGRRTMEEVMTQRGERGVRIADLNYRKASLELGMLKGNAFVITLRNVRVDSLETLDRAMNVIKTKGFINYYGMQRFGTASIPTHTIGLALLKGDWHRAVSLILRHRPGEHPDVVAARNAWLVDKDLDRALDLMPRRVVAERCILESYKKQKGDTRNAMGALSTIPRNLRLMYIHAYQSYVWNAIVSERIRTYGAEKPVVGDLVFEGASSAKADADGEDVEIALDAAEGENSLEDKVANEDNAGTSSRSSKRSRKAWEPPKVKTLTDADLDNYSIFDVIMPLPGKDVDFPGGALGERYREFLRRDGLDPDNFVRKQKDYTLGGSYRSVLHLPKELSWAVMKYTDPDVPLAQSDEDKLLGFPPPVSDENGKFIALQINLQLGTAAYATMALREVTKTETSSHYQTSLTQASEDQKYRTADGGAEEEEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-11-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9P3</accession>
    <name>A0A4Q9P9P3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_411639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145385">
        <property type="protein sequence ID" value="TBU51138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9P3"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9P3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="23061" checksum="5FBADA0E32759BDF" modified="2019-07-31" version="1">MPGKCERQDLKRPDIGRPVAAHRHDRQGVIRSHSCSLSLCHRHLYTSTKLPTSRAVCGRPRRKVAVRHRRWVVPLHRHGLQWCLLTVKRSLMTRLETLARRVNPLKDLIRVAQQNPHLVSLANGDPHFSLYPVRRINIEIASVSSSDDPVSTWRTLGPSAPTQTLASVIDEDSGPLLRASLAYGHGAGLHTVAEQDQVELSISNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9Y6</accession>
    <name>A0A4Q9P9Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_910778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145353">
        <property type="protein sequence ID" value="TBU51248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9Y6"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9Y6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="296" mass="31906" checksum="D7F8A6462BF76632" modified="2019-07-31" version="1">MYRPDQEGTQRKTSSNPRRVGNSPSPPISTPPSLPPQQHLSGVTLPVAEFLANNDFCLLNGHKDDSKRTSGAFGNWNKDLPNLLGGPSIRGHTCNISIASVQGHRLSSIPHSCRLSVRNSVVVGEDVRDRKQRHESSLNGSGAWGPSSDSLFQSSQARGSPERHYGAPNSKTSDKRSERGISPSSTQSGRPLVSSASSMASSKWLSSMSSAGTSTSAFTRYSNNSTRLVLTAATSMSSQSWCTQGVSGSYPHADACKCSALARMSITLLRTPPYCWVNYLSNIWSNHKGTHSTRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAB1</accession>
    <name>A0A4Q9PAB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Terpene synthase</fullName>
            <ecNumber evidence="6">4.2.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_690896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
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    </dbReference>
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    </evidence>
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    </evidence>
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    </feature>
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    </evidence>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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        </source>
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            <end position="644"/>
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            <end position="289"/>
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</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10823" checksum="B31B76C9DACB2B50" modified="2019-07-31" version="1">MHRLSMAMSPHLIATTVCPQFTFSVNTNMLILMRLCLEVNRQFLDREAAEARMKHQQSRIFVYIVVFIDASVAATLQRAVCPAVETSCSSRTSSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF10</accession>
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    <protein>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145216">
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
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    </feature>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="512"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="700" mass="73091" checksum="05379CC9ACDA66C4" modified="2019-07-31" version="1">MTALASSSSSLSPSGSRPRPRKDVFKPKFPLDPFHGHSAAALGEPWFLKIDALLSATALQRQNVIFVLGAPSLAELGPLLQSQRLAKSLVILATHNPPDIPGIVYPTVRILRLTTPLALEDAGAVRFVNVLEWAERVARTWRKHGSSGVCELSEEQDNNGELKPPSIFRLGTRSASSSPRSSTIQLPGDSSATISRPLSRPPSVVGALFSRQSHASLPPSDPFQRPFDVMVNFMPVNLSDKALLKNSILVTTISRPFLKSPVHGSGAPPPTLRTRTTSSSSTTRLARPQSIFSAFSRSTSSISVYLPPTPPYESGDSLPLSSSSLPAPPGKALLVHLLPSPPRGEHPAARRKLVDSMEAFLLSFSYQSTGLPSSRTYSSPAGAGPGLGGGSDTDRARPYVMHTSTFCDTVGCDPALGVVDCGEWSVADIVLSGALDADTVSSTSPAAPPPAAVLAGAGSGRKSKRAWIAAAADLVILPSSDNPTPGPSSSLPSGTEEPPVPVPAAERGMLQPSASSPSSPSSKWLNRATRSTSAPLLSADWTPVQFGGRPMSHPSHQQQSMPVSTSHRHPLAHLVAEEGERGSGTTFRSSPGHTVPAPTPTPPATSRSSTAASSLGPPTPPHSSEEGELPLDAIKEASPGAEFAAPRHTMGVAVMAASTVDISSVEGEGGMRGKGTVKVAKWKYWRRKTGANVPSAAVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF55</accession>
    <name>A0A4Q9PF55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carbamoyl-phosphate synthase L chain, ATP binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_1042327</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF55"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF55"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="36"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="155"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="675"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU53594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="757" mass="81606" checksum="4A2A0B48CDC6429A" modified="2019-07-31" version="1">MSRIRPSLGAREDLRQPQFHPETSFSSLLPSAHKPLFDKILIANRGEIACRVIRTAKKLGVRTVAVYSEVDSDALHVRLADEAYCIGPAPSAESYLRIDKIIEVCRQSGAQAVHPGYGFLSENAQFADRLAQEGITFIGPPASAIVSMGSKSESKNIMSAAGVPVVPGYHGTNQDPEFLQQEASRIGYPVLIKAVHGGGGKGMRVVHSTSEFRDALESAQREATKSFGNADVLVEKYIQRPRHVEVQVFADKLGGCVSLWERDCSVQRRNQKIIEEAPAPGLSSELRADLSEKAVAAAKAVDYVGAGTVEFIFDNDTSKFYFMEMNTRLQVEHPVTEMITGLDLVEWQLEVAAGNPLPLSQSAIPLVGHAFEARIYAENPRNNFLPDSGQLLYLSTPEPTHVFAPSLEAYRIPVPEGSSGFTPVHNTSAAIAPTMRLEQGFEEGAQIGVFYDPMIAKLVVHGQDRTEALRKLRTALEEYKVVGPSTNIEFLRTLAGNQAFIDAEVETGFIPKHFNELFPPVPEPSHEALAQAALFVVLRDHPAPSTPSPWTTLTSRRFAGDVYERTITLQSEEASASPSTVHIRALSNGRFDVTSHTASGSHTFANVSAHLASPTAVTASLDGALVRTTVVSQSPPANVPASSSPSTMERLHVFHGGRKTTVVLPSPEWLLSLGGDVLGAAKGALRAPMPSVVVEVRVQVGDKVEAGQAVVVLESMKTETVLRAPTGGVVKAVGCQKGEMVEEGRELVDVEPEEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG13</accession>
    <name>A0A4Q9PG13_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_941015</name>
        <name evidence="4" type="ORF">BD311DRAFT_771208</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143564">
        <property type="protein sequence ID" value="TBU21977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145266">
        <property type="protein sequence ID" value="TBU52107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG13"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597636" evidence="2">
        <location>
            <begin position="19"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="32"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU21977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="37316" checksum="717DF32EBD91FD05" modified="2019-07-31" version="1">MISVAGATLLAATAVAAALPKGIPLHLDHGFWYTKFSVGHQDFNLTVDTGSFAVLISQGLYKPTPVSNSTNQGEFLQFNGASADGTAPASEVFTFVHDDVKFDGIGVQGFLVGNITNGDPLPADGIIGFSPPATDITDPDDPTFLAGQSLVQAICDEEKISPCEFGLALKTDGTGTLSFGPLDKSKVKGKLTTLPTFSHDAWQVNNSSEADSPILVLNGKSFGDIVATFDNGTPNIIGPLETVRAALQAAGYDLQEVTSDDITTVLGTYDCSRPPARFGFSFPPSTEVHYVDANANVLNRTADGKVCTANVLGTSTLDVPQWQIGQTWFQGRWVQHNLDKSTIAFADLRSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGD4</accession>
    <name>A0A4Q9PGD4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145255">
        <property type="protein sequence ID" value="TBU52337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGD4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGD4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="8366" checksum="65C8356876AD0D71" modified="2019-07-31" version="1">MKTFIWQLAYLSNECCLIENENALEGSNRIVRDEGMLKNLHQKKSRWDADAKGNRPLFFKDFDPEMSHDYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH03</accession>
    <name>A0A4Q9PH03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Macro domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145238">
        <property type="protein sequence ID" value="TBU52747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH03"/>
    <dbReference type="STRING" id="114155.A0A4Q9PH03"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30917" checksum="AB33023FA1B44152" modified="2019-07-31" version="1">MLVPTTVAASANATRTARVPHFVFIARAHRDAPHRDSLVDAWRRAIAEYFPADGAEGQLGPGEAYFTVREGTLEELDPADVRNDCIVSPANSFGIMDGGFDLVLSRAFQGRSADVYALTDHVQATLGTRWGGFAPAGTCTLVPLPAGVSGRGGNKWGTHTLAVLPTMKEPEWVGWHRELVYNGMWSLLCEIGRWNEEAEGAGRDAGGRQCLETKREGEKKGQERIERVVMTGLGTGTGGVSAARCGRQMVLAVKHYLQGLPEKVRWDSAEEKRRMQDLNATIDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH85</accession>
    <name>A0A4Q9PH85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_982075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145265">
        <property type="protein sequence ID" value="TBU52126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="123" mass="13465" checksum="C1451B06EB76F1DE" modified="2019-07-31" version="1">MSSPHPPSPSQSIRLRLFVLSSTICTDNSTTPVAIYWQRKDEDNSGRRISRVAIAEEGRDDSDGATSARASRLLRPSRRAAGKTHKKAAEQWSHPALEADQAIEVLKETVAEEIRPAQEAASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJW0</accession>
    <name>A0A4Q9PJW0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_78131</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJW0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJW0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="176"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU54382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="401" mass="44538" checksum="AFFB2387848194CB" modified="2019-07-31" version="1">MPGTIITPSPSSGLKSYYQAKIEAAELEINQKTQNLRRLEAQRNALNARVRLLREELQLLHEPGSYVGEVVKVMGKNKVLVKVQPEGKYIVDFDSEIDVASLTPSLRIALRSDSYTIHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCKFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRGESGSGGGDSEVQRTMLELLNQLDGFESTKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPGPEARVAILRIHSRKMSLQRGINLRALAEKMGQCSGAEVRGICTEAGMYALRERRQHVTQEDFEFAVAKVLKKNQEGNTSVNKLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJZ5</accession>
    <name>A0A4Q9PJZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_935926</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="ML145189">
        <property type="protein sequence ID" value="TBU54422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJZ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJZ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="77"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="90"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU54422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="966" mass="109567" checksum="503CBBBA8E61A496" modified="2019-07-31" version="1">MSTIKRVLSRVVSTHTRSLSKGSGKDSPSSSTNGEPKSPIKYFTNGHAKNLSEEPVQADTAPETHQAHENGSPVPRPTSTSRSRSLSFTELKEDRKAEREVKDEEERRRRKEQMQKAHDEDPYRDNWGDKELNASQSRSDRPLDKLRDFADKKEGDRVVFRARVHHIRALGTKIVFLILRHQFTTIQGVLTEEPEKVSQIMVRWAEGIARESIVVVEGVIQRPPPNQEQVHGTTIHQYEVHIEKLFVIAAPSEALPFQVEDVSRPKEYYDREDAHFVRVGERTRLDHRVLDLRSPAAQSIFRIQAGVCELFRSFLVERGFTEIHSSKFQGTSTESGAAVFKVDYFRRPACLAQSPQLAKQMCIAADMERVFEIGPVFRAENSNTHRHLTEFTGLDIEMAIESHYHEVLDTLDECFKFIFKNLLTRFRSEIDTVKKTFPSDDVVILDETPRLKFAEGIRMLKESGWREEDGSEPDEYEDLSTRAEQRLGQLVKEKYGADYYILDKFPLDVRPFYTMPDPENNKFSNSYDIFLRGEEILSGGQRIHVAPFLEQRMRESNIDPDTMKEYVDGFRWGCPPHGGGGVGLERLVMLFLKLGNIRWASLFPRDPRSFVVRNHDPQEAAAIAANSLILHGPESSTFQPGKRHGELPPLENLIAKYGDATNTSWVDPSWTIWRDKATGAAVGYIPQNGFAVIFGNPLCEVDQIPRVAKAFLAFLQEEHLKPVWCCVDKQTEKYLAEDLGWGAVIAVAEERINPTETDPAEHDKTVRRKIHRAEREGVKVIEVGQEMDPSVKEQLEQRCKEWEANRKGTQIHLTGVRPFDDMHHRRYFYAVDKDGKICALVVLAQLAAKHGFQIKWALEFPGAPLGAIEYILAYVIKKLGDAGVKTATFGAGATGTLQAADNIHGFKVKTLEKAYNGLSATFHLTTKGDFRSKFGTWHDPLYICYPKGGLGMKGIEAVMAMLQKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK68</accession>
    <name>A0A4Q9PK68_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_935646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK68"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="261" mass="29252" checksum="B18860C49F41E80A" modified="2019-07-31" version="1">MTGYCHSTITTGRRSRGASHVVLAARHRPHTSTERMTPILVKWIYSTLYLPYAVTAPLSFIEHWVQDIQRTSTCLDLTISLTGQTDSSHIVVAKPPMPFTVNPDELESPIRHGALSIDLTGDDMSHRYILNPLLRHSPPDGPLLLHMSPDEALWTTTAPLFLAGFAYRAPFPFAITELIVRSLAFPSPANLVAFFRGFPGLRRIQLVRVRREKPWTPYQPSTIHGVPDRPSHLTELHMLGGLHTLESCMSSVLLLHRLSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMG5</accession>
    <name>A0A4Q9PMG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_826027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PMG5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13365">
        <property type="entry name" value="PH_PLC_plant-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF1">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="1365"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="102"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="355"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="435"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="898"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="987"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1172"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1300"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1485"/>
            <end position="1557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1625"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1670"/>
            <end position="1706"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="840"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1025"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1099"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1187"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1255"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1269"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1308"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1517"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1533"/>
            <end position="1548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1706" mass="183650" checksum="93B80724C2782917" modified="2019-07-31" version="1">MATFSDGGDVDAISDHDATGNIRLHLQNLLDSKEKQLQSAATLGHQLLAQRMELEERIKQMQELELDGTGSDDGLDVSVRDKYRELADAMKAWDTENEQLTSVFGSKPTNGVHAPASRHTEPSRNEHERSKGAVAGPSAAQSSRRAKNAAHRADDVEFAFEIGSGLLTEVRRLQSLLGERDKAIQDMKEEKDDLEKSLENLRQALRQQEQSADKFKEENWNLEVTLQELRTQAADSQATAQRLEGENKRLTRLLTTTRETADQHKNEAERQQVAFEELKAKHETDVAQARKHAASLQRDKSDLQQALDSMKAEVAKASRRLPRFGSPLTPNGLTASEAVTPADQDEDDVFSTAAASTHTRKKLDNSGLFPPDGFDFDESPDPSPSKTFLAPNHPTNEIEALQQRLAHAQRQISTLKSTLQREKELRMDYRRKLEASPGFAIEEEEDDVADEDAEAAPKPKARLTPYRSGRGRGRGRGRGGLTLIQRLGMAAHSPSSEYNDDHDFDTSPAPSVPPIPAEFRQGADLDDEEEFEEPDLQASPSPAVNSNRTSVDGMDPAFANVLRRSVSASSLQNGSPLRQSVLARTARGGTLPRRSRGGAAYQEARPPSLVGQPEALAAELGFGMMEAEPGSSIADDLQQEFADIETVEFGVQTDFEEPPPPPPIIQVIPPSTSEMAIQVEPEPVPIVSTTEISLQTDPEVAPILADAEIQVDVVPERPAPTFSSAETQTTAPGLAGTGVQTQPVSTPAAAIAAAYTGVHAADLSRSSSEDSGNATVRLRRPPSLTFSETAMLEEDDDGVTETGSITGDTTHTEDFTDAYSVPVTPSGESLSDYHSIRTVSESGYSDSGSDQSIKASRVQTDSAMSSSVSIPQTSPAVLAPEPSPVKPPLTYATVEIETDPIPEPPPVETAEQGIQVEPEPEPVLEPEPKPVLVTIGVQAEPEPEPEPEPKPVPALVTVGVQAEPEPEPKPEPVVVPAPAVVTIGVQAEPEPEPEPVVVPAVLPPAPEPSPKPETKDMSIQTDEWIPPPPQAPVPAPATAPSAASTPAVVPIPIPAPPSVASSASSIAGAAVAASASAAGAAAGSIPTVFRVGPSSQQFQFIPPSSAGPTTTATTLPTPAVPSPVSSPSPNTTIRDANATFIARPRTSHSDRRQSIESTLSSAMDDIMTRSRTPSVLPNIDKTRPPMMVLPPPPRQPPPPNTMLPPPFIPEKRMSHDIPPPRPSSPPPVELIQRATTPNLGIPGRGTIGRAHGSSMPPSQQGLRQLPSTSSFRSAANAAARAPLSSPSALSFNLRDRERRELSSASLNSGGHSIGSQRSSISSDHQFEAHMRRHSNLEATVQERAGPIAGGAPVSTDPAIIHAITQTMIGEFLYKYTRRAIGKGHGERRHKRFFWVHPYTRTLYWSSADPGSSNVTESSAKSAYIESVRAVMDPNPMPPGIYQYSVIVSTPQREMKFTAPTKERHDIWFNALKYLLTRPGNAHISAPGQGDVGAMSPMSVNGELPEEYPANVMSSPESQRSTRTGRTARSGDSWNITPRGQRSRSQISLGGSMGKRSGTPAAEYLRWAEAPSSPTKEYEHVPGGDDEDLDFELHDETLSDEGFEGLENVRACCDGRHTVGRSGRIEHHHHHHDHNHDHNHAPQKPAPTRAREQLLDPNAIEMQRPVSPAWSFRSRAGSSTSHEGGFFSRFGTRRSTKTSTSAAGQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMP8</accession>
    <name>A0A4Q9PMP8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_933584</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMP8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="166"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="337" mass="37141" checksum="81905E23253AB716" modified="2019-07-31" version="1">MPEVSLNNTLGAAFLGTIATSCFYGITVVQTYIYYKRNGTDPAYLQALVFFLWVMDSLHLALVVHAVYFYAVTNFTNVFMLDIPIWSILSQILVTGVSDGAVRGVFCHRVWRLSNRNYVLVVAISISSLIVFSGSIAFAVKGFSIPTFTALSEISDILYISLGSGVVADVLIAGSMCFLLAKRRTGFTRTDSIVRVLMMYSINTGALTSMAALLTLLCYASMPNNFIFIAFYFVLPKLFLNSLLATLNARQPLRESGSGDMVSFPLSATTNSRLSFSAGRPQFTQSLTNRDDQRNLQIQIQTTTDTKSDPDPHGVVDEELKPWPVYARTETPIAFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMW2</accession>
    <name>A0A4Q9PMW2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1028726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMW2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046521">
        <property type="entry name" value="DUF6698"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20414">
        <property type="entry name" value="DUF6698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="411" mass="46672" checksum="D727A3DF6BDE799A" modified="2019-07-31" version="1">MAEAVAKEAKRRRIDDAVSSDGATEETQSETAVTSPVEPKNPGWVIQAWNCDASASDIVRHSRGIEQMYDAARQIGRCSSEYPDQTRALTYGVIFRGFDAENRPDYISNYYSEDVEARMVFLIWDRYFPELEDHLPYLAANPALILHLGNYVSFVAGKVRSDDLGRLNLGIISYSLLDDPNNILKRHSNRGFDDSRTGRLLCPVRYLKEFEADPARLCSLFRNHHPDWKLFSYDFPSFMSDLSLVDPDDREAGFLRGPLLVTYYKAIFCGRSSVYGEACSRGQQSLVVKYGMTEVNLHSIVYTTLLARSALGSDAVWRDGDGYHWQAASFLHAVMDLAHKSPSWSRDTIAWWNKQIFGTEDGNDSETERELEESDYYKILAQRAARNRSPNPLISQSPVEEDEEAEQPEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNT7</accession>
    <name>A0A4Q9PNT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_979346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNT7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="588" mass="61109" checksum="D9E2B9A71CF78BA1" modified="2019-07-31" version="1">MVFGFWSQPAGKTKEPATESKLPSEPTKPSAEAAQPARELKPAGEAATPATSGNGAEVPTQEAEPVPSAGEQSSAPADPEPRPPSQKRFSWRILVQPKSTQDRKHTLPPAREEAEKEARARQEYIERKMVRTRSERRARDSALLVRELIVGPFAVPSAALPKSSKVAVTAASNQKVHKVKAQLLEPKQANKVIAQLRQLPSSDVPVVVGKTSAGEDIKALSKGPIHAVCLPMTDAEADVRHFAKLDKVEVAVPSPSASGKPSPKSSPPTVARNLDLTEAVSGITSVTATSLAKLTSVFKDVDVVSLLTVPNWGLGQPGDQPGILSGAVPSAKAVIEGVEEITPQLMALGYATGKSILPSHDGVFPPTDRMSVLTYWWGLELVVPEPSVKFLSNAPSVAHTVVNFLTALSVGNGGVAEILPFVRYFSTYIDMEFNQIRSQDKGKGVVCAATWIMPAALVPRPWDFPEPPVNPSPPPSAPSAPAPGAGAIVPTSSLPTHDSTPVLVAPLGAAAITSESVPGNQEQGVPGVTVTPPTPPASESLIKSVGAAAAGLSEEAADKVDENGIAAVGQAGAKTGVMNGVPIAAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP50</accession>
    <name>A0A4Q9PP50_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_932417</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
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                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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            <dbReference type="EMBL" id="TBU56016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12748" checksum="56C8B298655B5EBD" modified="2019-07-31" version="1">MSSSSVGRTNSRMRTRLQIVRGSQCDCLLHRSWQEVSRRCTHQKDDLLFHYNICSSHPFRSPQKLDNMDTYWPKSSIPGGKCATVSSIYHRCSPEDERYPVITGIPVRYL</sequence>
</entry>
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU56644.1"/>
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    </evidence>
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        <source>
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    </evidence>
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</entry>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
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        </lineage>
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    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUM3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12022" checksum="DCC3CB61205D0B62" modified="2019-07-31" version="1">MCRMPQVTHGCAKNALARSVCKRLSSWVSARAGLHPSIAVILTSAYLAQGKLCYAEFARTIGLKDRIPYSGGSGSLDSQDKLVVRLCTIYRQRSTPPVHLGLKPSPMRHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUN4</accession>
    <name>A0A4Q9PUN4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease H</fullName>
            <ecNumber evidence="5">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_927321</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="5"/>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUN4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09280">
        <property type="entry name" value="RNase_HI_eukaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.970.10:FF:000002">
        <property type="entry name" value="Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.970.10">
        <property type="entry name" value="Ribonuclease H1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_bL9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011320">
        <property type="entry name" value="RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037056">
        <property type="entry name" value="RNase_H1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01693">
        <property type="entry name" value="Cauli_VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="L9 N-domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-1" evidence="13">
        <location>
            <begin position="147"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="337"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU58267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="471" mass="50574" checksum="0413E57848082EE7" modified="2019-07-31" version="1">MVNGVCFAVARGRKPGVYINWSECEAQILNFKGAKYKKFLYAADAELWIHQNATGPCLLLKPEQAAISPAVQGPVPALPATPGPVEPCASAPPQASDPDLAYSATKSEEVHSKVRNWQRAIARDKLPGVLQHSVDPVTEENSTIPMSPDVMIVYTDGSCKGNGTEHAVAGVGVWWGDYDSRNICERCPGDQTNNRAELIAIIRVLETTPTNRPLLIKTDSEYSIKCMTRWLWSWKAKGWKKIDGKPIKNLPLVKYLDVLLDERRTVSKQDVKFEWIKAHAGLSGNEDADALAVAGADLPAVPERDWEALAHAVRARIVAASSSSSVAAAPVAAVAERASQVTDCPPKVMTRSATTQPVAPSAQSQAARKPVPTPSRMPSQVSASQPAPPRTVPSRSSTPSTTSPHPSASQATSTSGTNISDRKPRTPLSWSEGDVHGSADIKVSQKELEAYVACLLNDDDLLEEARAAGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV05</accession>
    <name>A0A4Q9PV05_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide hydrolase</fullName>
            <ecNumber evidence="1">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_977420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="1"/>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV05"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.30:FF:000008">
        <property type="entry name" value="Glutamate carboxypeptidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF46">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="3">
        <location>
            <begin position="232"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="407"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU58427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="536" mass="59762" checksum="09C04B809854DD13" modified="2019-07-31" version="1">MKENHDPEKILLLNRDEQNEEEPKRSRVWWGPRQWRGLRNLVVVLVIYGAYTVAMHVLAPMQHDEHHHESLYWAKKAAWKQRGPLSPEKVEEFYLSIPDPGSALAISREYATHPHVAGSVEDLNDAKVILKLFQDEFGIHASEDIPLYHAGTHESRSATLDIPKYHHPKAWIDQYFPVMNTPLDRALSILGEDGKPEWEADLVEDGDPHDPDAAKYRDAVPTFHGLSADGEVEGQLVYVNYGRKEDYDELIAKGVNLTGKLVLARYGGVFRGLKIKGAQELGAVGVLIYDDPRDDGVVTVENGYKPYPEGPARNPTAVQRGSVQFISLYPGDPTTPDAPAYENATRTDGENIPKIPSLPISWENAQRILKEISGKDVKAALTLNGKASEKKVKLVNHVDTKVIPIWNTLAVLPGHIKNETVLIGCHRDAWVMGATDPTSGTVSIHEVVRGYGALLRKGWRPLRNVVFASWDAEEVPTVSPASSYKLYVSNVGLDLQYGLIGSTEWAEDFPEWITENVVAYINLGHGQLAHPHRSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVR0</accession>
    <name>A0A4Q9PVR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_926713</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVR0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16619" checksum="9E95E0796DA59DF9" modified="2019-07-31" version="1">MTRRFAGVCQPGYKQFITEAAPDVGVKSQPVLLGLVDDDRMDGVCNAFNGVYRRCCLLVFPLCLWHDCRPSPLAGRRRSRCGLGAPPPCALTVGHRDDQSGPARRGVSGCEAPSESGSGFCFWLSRRRVRESLPAAVLGLRKHVTNASTQTSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWI4</accession>
    <name>A0A4Q9PWI4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_446538</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWI4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="136" mass="14917" checksum="06C036E88F373375" modified="2019-07-31" version="1">MGGRKVVIEVIIVRLESRKSLLGTLCLVCAHAGWPMRPRQLIRCPVVRVLLADEPVAHLGLSLEPSTGSLRLLIILPSLVHTYPLLLSSFSKTAPVPLLSCQSYPMPTNHLQLPMPRPFVHPCHSCGARSSLRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXI1</accession>
    <name>A0A4Q9PXI1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Quinon protein alcohol dehydrogenase-like superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_925107</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXI1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXI1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="582"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="624"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="665"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="747" mass="82824" checksum="7F0085FEA25B9A10" modified="2019-07-31" version="1">MCYTRLSVEVIEMVVDQLSDDVPSLRTVALVCRGLLPRARYNLFVDIGVRNKNQMNTLREFLDERPYICPLVQCVTLSTTDGEPNSFTLLETIPVPLLTRLPNLRRWRATNQSLDFKGQHWLSLNHSTLASLRKYTANISHLSINALSFSGCMDFVRFVSAFSGLHSLVCEEINVKTEGVTPTMATTYQRLAQQCRLSRLIVRRDVSEAAVASLLEISKLTLRELVLVVTRQQSNSLQLLALAEQLSQLDSLTLSMPVDPHLETFVRSVWGIAAFFKYLSTMLPLQEIRVECYGSSFWALDAMLSQQGTSEACQQLEQVLLAVPRHSMQFRIVGGGRGSKPLKGNLRNMALKKRFRTLWKKGAIRVELPRSTDTAHAETTAVRGHSRPVKALLVSPDSRWVASAASDGAIILWDARRQVLSREWSAVGKVEHFVSLAFSQDSRCLASAGDHELVVWSIKDGGEVDRLDALQMEGTTIRACSWSPDDAHLAIGCTDATIHILHGRTFQELRVLRFARGARPDAAGRGPGSSVERLSFNNGRWLLSGVERLLFANARWLLSVAPDVSHGCRLWDIAAGKLRTVLRGHTASITTASFNPTGTRLATASMDHTVRIWDIDRAAPLAVLRGHTGPVLDVAFSPDGKFVLSASEDRTAKVWPASGGRCTHSFKHFNWVYAVRFSSDGRYIATASWDHTVRLFRASDGALVKRLWEHAGAHVRHLAFSPDGETLWSGADDGSVSGRRLSNIIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY02</accession>
    <name>A0A4Q9PY02_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1008786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY02"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY02"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="661" mass="72680" checksum="FB1E087977AC1D72" modified="2019-07-31" version="1">MDAVSLRKLPRKALQRLAKTNGIKANLKSEDIIELLLKKQEAQPSAHSPQHIATATSKAGQRQSSEEPPQHGNPDPARLSDPLNDPGVGTCSAERHDYHGLMHIKDPRGPPASMSHEPSVLSETTGDRPPRDGRLYVPPPSGSYALPSFQHLVSTLPGPGHGPSHYIPQAHTLNVFDVSSASRALWPYANPRPPEPSPTSDSHSPQEAYPASLPNSTEYPKGPYPSTASTSDVYGFSLSSSHHGSQQAADRYIPPLDAGASASTNTRAAPIAGGSDIGPSYRPRNPTPTEEYDSLLGGPAFTEPGSDYVEEWTPYTCEMSAGPSDRQPRPSAAERPMQSPAFPLTQAVFEPPARPAYPPRDSPVFRPPSTPQSRAQARPPAQPLPVPTIQPPQVAVESHQGEAQAEEEIDWATDEELHSMVSKMATLARHMKARWDDIEPMMLECNRTGKSVLRLRTILRQERARFDRMREYLGHLNVRLSPDWVEEEIWDKACPVRADKDGNIIEIETDDEEEAEWRRKHPRPYNAQPTEIIMKKYAPVVSVEDSLEDLETIVPRAAIAFARLHEGSNIQSRQGPLPQTPKRRRDGGDPGRAAKRTRGSAGRTPAPKAFLAGNGAGAMERERQQRKSLSLAEIVEEEEDMEMTSVVTMLNQPIYSSDRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYD6</accession>
    <name>A0A4Q9PYD6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_817036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYD6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYD6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020339889" description="CFEM domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="6">
        <location>
            <begin position="10"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="15138" checksum="A163E4D2E3B9742E" modified="2019-07-31" version="1">MKFNAVAFTIVAVVARVHAQSSTAGSAAPTSTNGISPCILTCIQQAASANGCSSALDVSCLCSNTQFQQSALSCLESSCSSSDVQAAQALQSAECGAGHSATSAASSHASSAASSVASQTSNAAMSGMRGEWGVAKGGLLGVAAAMVGVVAGAAFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYD8</accession>
    <name>A0A4Q9PYD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_924727</name>
        <name evidence="3" type="ORF">BD311DRAFT_657573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143401">
        <property type="protein sequence ID" value="TBU31156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYD8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYD8"/>
    <dbReference type="OrthoDB" id="511599at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056808">
        <property type="entry name" value="HTH_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36168:SF1">
        <property type="entry name" value="ORC1-LIKE AAA ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24913">
        <property type="entry name" value="WHD_AAA_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="1">
        <location>
            <begin position="62"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="AAA protein C-terminal winged helix" evidence="2">
        <location>
            <begin position="305"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU31156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="467" mass="53484" checksum="FE4D8CAA0AAE4EBB" modified="2019-07-31" version="1">MAWYKENVLWKIEKAFAGGYDPALELAQHPVRRPTQPEVFEEDGLGWDLDEPWTQHLRRTEQDLIDRIVKGEEVGHYYILLGPKGTGKTTMILDAMRAIEAEGVAMCDAHPDLEVFRLRLGKALNYEYNEDTQTGLFQRRDPREAGPSLDIERAMNKLEKVALRHARATGKPLILILNNVHYFNHDDAGRNMLLQLQQRAEAWAASGILTMVFSSDDFWPFFVMRNNASRMHVVSVYDLSRKESVTAAVRMRRNAHRARAPHEAFEEAVGIVGGRLTYLGKVTKAADMVKQAKHMLAVEKAWLLSQIGLIPDCDDDVMDEQKWSSCSWLLLREFVKRRREDVAAKVEEIKRGEAEPEDLNNLALPRISYYKARQIMTRADFMDELDRKNIIAIDIHHDVTPDSMLILHAAEEVCAEEGFDELLEGVRDRVDEIESLHRTRELTFKDVDKGDRIRLTVDKGGARLVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYQ5</accession>
    <name>A0A4Q9PYQ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_976257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYQ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYQ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061671">
        <property type="term" value="C:Cbp3p-Cbp6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037653">
        <property type="entry name" value="Cbp6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28250:SF1">
        <property type="entry name" value="CYTOCHROME B PRE-MRNA-PROCESSING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="12098" checksum="8A8295E39CC5F56D" modified="2019-07-31" version="1">MAAAPASLKHQLQKIAGRWAEDPFRPNVQLKTFLASLAEHPNLTPAAVRATRALEEDEFKKKYPLSDKIFKPASMPHHYTRLLEAFEKAAQGIARPWWKIFFNIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ31</accession>
    <name>A0A4Q9PZ31_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_363488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ31"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17857" checksum="1BC7A1D1C9813F02" modified="2019-07-31" version="1">MFYEALGRVTTVLQCNSIFTSGNHPVMPTPSLRRSAVSLSIDNLASSLHEVRPTTQPSWRLSRTALWIFLDAMAPSQQRFSLASRELLGEYAGTVPTYRRGARSRTEVPWTIGVTAYALQMSDPCSSGHIPSDKSYQDARQRHSSGHSLLRATDDYANPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZA0</accession>
    <name>A0A4Q9PZA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_905520</name>
        <name evidence="2" type="ORF">BD311DRAFT_852796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143459">
        <property type="protein sequence ID" value="TBU25575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZA0"/>
    <dbReference type="OrthoDB" id="2757521at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="252" mass="27330" checksum="D24BCCD85B84568D" modified="2019-07-31" version="1">MSQRAHNQYTADDGVKWQTYADAFTAWLVQPTRETYPGNPPEGYYDVFKKRQTYAPGPREFAQLVASVFQPAQPAPPPSISSGHSVLMSTDAFNAFLNHRSGTQDQILQFAQKDRGGTPVAPNLGGGGRYGGWRAGGRGGRGGGRGGGFWPGRPTYGRPAVRVPFIPLAGRVNNPVDKGKQTGGKATNRKWRYRKRGGRKGKEAAQPVQNDEEREAGPSHADQMVVDDEGDNGRSDPEEDLEDAVSLGEGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZQ8</accession>
    <name>A0A4Q9PZQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_923494</name>
        <name evidence="5" type="ORF">BD311DRAFT_759212</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143425">
        <property type="protein sequence ID" value="TBU28114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZQ8"/>
    <dbReference type="OMA" id="WYVNGET"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF4">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_7G04540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU28114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU60185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="313" mass="33543" checksum="18C407D3ED81F879" modified="2019-07-31" version="1">MADSVLKELSSTSLFDLTGVVAVVTGGGTGIGLMITTTLIANGATVYIIGPKQEDLDKIAKVYNDAAEKERKPGRIHGIAGDVSKKSEALRLADEVRKREGHVTVLFNNAGITTTAIKRPTEATAEAYVKAFFDPVSEADFTNTHSTNAVGPYWLTFAFLPLLEKWKESPGGQRFAPQIVMTSSMNGWTKDLATSGFSYPYMFSKAAIGQATSTLAHDLLPLGIRVNGIAPGLFVTEMSSPGTIDELGRSHFPPGLEWGFEVPVSRPVPQGTWGAGTNKDMGALVLFLVSNWFVDGETVLIDGGTMLRHPSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1Y8</accession>
    <name>A0A4Q9Q1Y8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_814107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1Y8"/>
    <dbReference type="OMA" id="VECANTQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="195" mass="21335" checksum="7250AF2283D6F534" modified="2019-07-31" version="1">MSAADVEFRAELNQYRREQTVKTHGLAHLNNLGAGIIMGDETLDRIADCARAQKLTTVETLYQETKWPKSRELGADVLKLIKKYYPANSPFASTPLRVRQSEPQADGAPSQSSNRAVSATAKAPRQCGACGQYGHIKSNLRCPARDKQAGSDDKENTTVTVEGLHGDDRVVRTVNDRVVRTVDAVRDIGDSLVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3K6</accession>
    <name>A0A4Q9Q3K6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3K6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3K6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020664292" description="Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family-domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="168" mass="17783" checksum="73C68DBE16F39514" modified="2019-07-31" version="1">MARALWTLWLLYLFNLAAVRASPHFEAGKDDQVLIADFPPPVERPGGADVWTVGDVETVKWSTKGLNFTLDQTGTILLGYLTTDGSQTLFVDQPLAGNFTLASGAVNVVVPKVPSGNAYFIIVLGDANNWGPLFSIINPNEPSLSVAPTSLAWISGSAAPSITAVVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3S8</accession>
    <name>A0A4Q9Q3S8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_147585</name>
        <name evidence="2" type="ORF">BD311DRAFT_763514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143452">
        <property type="protein sequence ID" value="TBU26033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3S8"/>
    <dbReference type="OMA" id="KCYSSED"/>
    <dbReference type="OrthoDB" id="2734101at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045469">
        <property type="entry name" value="Nis1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19271">
        <property type="entry name" value="Nis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597649" evidence="1">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU26033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="146" mass="15009" checksum="BD630AE3AF378AB1" modified="2019-07-31" version="1">MKSFVALAALAASAFAQRIQIGVPANLAEIQPGSNITVEVDRPNSLTGSTEVALAIGLFPCGGVKGATSCSSMDVSQVLGNVVYNGPYNPQYATDAPSKPPHQNFSVTVPSTFQSGQVSLGVAHFSLVGAGQSPLYEFVNVTLVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q463</accession>
    <name>A0A4Q9Q463_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_766107</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q463"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q463"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070139">
        <property type="term" value="F:SUMO-specific endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051947">
        <property type="entry name" value="Sentrin-specific_protease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896:SF3">
        <property type="entry name" value="FI06413P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46896">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="100" mass="11267" checksum="014066C048B2A3C3" modified="2019-07-31" version="1" fragment="single">YIYTFDSLGSKHPAAANRLAKYLRFEAVDKKGLQLEETRLAVVKHAKVDLFPFFHQATIPCADVFLVQSPLQTNFCDCGLFVLAFVEVFMDDPVRAGELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4C1</accession>
    <name>A0A4Q9Q4C1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_920095</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4C1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="522" mass="56822" checksum="87D107BA91E2884C" modified="2019-07-31" version="1">MFCLSFFSFVALGIAGAASVVSDDVLGVDLSLRERNSTTSLIDCLTRAGLNPVTPSNPTYQNDSLPVNLRLIYKPAALVYPNTTDDVSASVKCGAVNDVKVNARSGGHSYASFSTGGEDGHLVISLDNLNNITLSGDYVTIGTGNKLGPLYYFLWENGQRAAAFGTCPQVGVAGHLHGGFGYHGRKWGLFLDQVVEMEVVKADGSIVIANNHTNADLFWALRGAPPSFGIITRFTVLTHPAPTHAATFAFTYTWSTPEVASSAFQIFQHFAAETDLPSDLALQVRYTEATPVPTFSLNGAYYGNDGITGLNRTVQPLWDALGALNDSVPTATIFEDLNWIQNVVYEADSDPTIDPKVALQEAQGFQIPFYSNSLFYPADNLLTNASTLSFTRYTYNGTSADVNWYVLWDVFGGKNSAIAAVPQDATAYNARDMLMNLQILGYSTTLPYPDDGIPFITGILKSVTDPMPGGRFMGYPNYVDSQLSREEAHAWYYPTHTAKLQRIMREVNPKAVFDYPQGFLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Q1</accession>
    <name>A0A4Q9Q4Q1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_85293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Q1"/>
    <dbReference type="OMA" id="YIKHANI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27904" checksum="66169C58F76A3A1A" modified="2019-07-31" version="1">MSRRMLSSFGFEGKQTLADDLESLVYVVLYCALLWLPHDLSQDDLQAAMKGIFELSRWHPVRKAFVGGDGKIGLALQHDYIKHANIPAPFQRWLDSVLDHMIPVGGGHSGPRRDTSQWSADQLDTFWADILQTETLEQNDRVVRDYPRALGDYEPQTGLESTEAIVLGKRASKERDLDEPEPDKKAKRPRGKKLAAEAPKPSASLGLPRRSLRLAAKAKQGPQLPIVAKRAPKERVASNPRRTGKKGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4S6</accession>
    <name>A0A4Q9Q4S6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_920112</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4S6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4S6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="408" mass="44644" checksum="34C4280C97B9C96B" modified="2019-07-31" version="1">MTMVRNQGASVNAITVSPDSRWIATGCWNQTVVLWRNRSGLGEATLAWRGDSSSPQSLAFSPDGGRLAYPASGRTAIAIRNTTSSDLLATLRMNEAAIDDLTVWNSRCMCVWSPDSSRLVAVHRTAGEMSRSFAYVWDAETYAALRTVANGEPTPPIQLLPGLTVLPPIAVYYSSDGLRLLGAKYTQQEWSSPSAQCPMEVKIDVWDVVTGVSHRPPKNGAVEGPARSLVCCAAALDSQATQCAVWVFGDTIHLFDLTQGGLQWATLRHASRMDTHDQHLMFCSTGQRLLSWHTRRPTPDLPFIQSHGTSLKLWDTRSGKDATSGSSRFNGLSMNHVCFSPDGQHFATASADSPLVDVWKASDGSWSTSYSIPQPAHDFDYPEQITFSADGTRLWVGTFRGHIYSFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4Z5</accession>
    <name>A0A4Q9Q4Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Antiviral helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_872419</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4Z5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4Z5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000354">
        <property type="entry name" value="ATP-dependent RNA helicase SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000987">
        <property type="entry name" value="DEAD/DEAH box RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000001">
        <property type="entry name" value="Ski2 ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1500.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040801">
        <property type="entry name" value="Ski2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17911">
        <property type="entry name" value="Ski2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="294"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="577"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="175"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="495"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="495"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU62150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1261" mass="140546" checksum="5AC7545A55ABC0F6" modified="2019-07-31" version="1">MSTQHEDLMSQILNCEPGNADIILANLGLASLPSRDEVHTQIEQNLLLPKSSLPDHWLPAYQLHWETKFSVPSLLNLEPSPPPTSLAFTRTGLKGSVSGYTEVSNPRLATGLSSTAIDRAPGPSRNFVRGKSGYVPFWPGGLDNLKTSKDVAEFEEGSSKLRTIAPGLSRGFRLPGDTANDVDADVVGLTTPDNTRGDPDDSDGHAYGRSDEETDGRMPLVNDMTDIDKLLPTSRSHLNPVPTARRQLRRANVQKRDWAHEVDVNKPMTNFHELVPEMAHKYPFELDTFQKEAVYHLEMGDSVFVAAHTSAGKTVVAEYAIALAAKHMTRAIYTSPIKALSNQKYRDFKQTFGAASVGILTGDVQINPEANCLIMTTEILRSMLYKGADLIRDVEFVIFDEVHYVNDAERGVVWEEVIIMLPDHVNIILLSATVPNTKEFADWVGRTKKKDIYVISTAKRPVPLEHYLYAGRDLHKIVDADRNFISAGYKDAQDALRRKQDKEREAQGLPPVQRMGARAAAPQRGQRGGPQARGGGQRGGPPVRGAPARGATPSRGGGSGRTFHQPDKNLYVHLLGNLKKRALLPVVVFTFSKKRCEENAGTLTNLDLSTSVEKSEIHVAVEKALSRLKGSDRQLPQIRRMRELLSRGIGVHHGGLLPIVKEVVEILFARGLVKVLFATETFAMGVNMPAKCVVFSHIRKHDGRSFRDILPGEYTQMAGRAGRRGLDATGTVIIVANDECPEQTTLSHMILGTPSKLQSQFRLTYNMILNLLRVEALRVEEMIKRSFSENASQRLLPENQKKVVQVELELAQMPQLECEVCAPDIERFYDITYDIVESNQNLLKLAGSSGGRYLEPGRVVVLRDGHFKSNIGVLLRKVSLANTEDNTKPYYALVMVSEDTKSKKHGALGDYDCVAIVLTYIPSDTRSVPPRWPLKPESLLVDEPVYELTAIKYESIALVTSDVIKVDVGKILEKLRISAMNATIQQLQGVLNGWLQKNSIPEPVWARRRFLEFQELLRHRDALAAKLGEFTCTSCPDFDDHYNFIHARKVLEANIAELKLSISEQNLELIPDYEQRIEVLKELKFIDDNSTVSLKGRVACEINSANELVLTELILENTLAAYEPEEVVALLSCFVFQEKTDVEPVIPPKLQEGLAAIVAIADRVERVQDRHKVPGEEFRTLKPGLVEVVYEWAKGMPFEQITDLTDVAEGTIVRVITRLDETCREVRDAARVIGDAELFKKMEEAQIKIKRDIVFAASLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5T6</accession>
    <name>A0A4Q9Q5T6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_870889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0014 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5T6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5T6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005226">
        <property type="entry name" value="UPF0014_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028:SF0">
        <property type="entry name" value="PROTEIN ALUMINUM SENSITIVE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30028">
        <property type="entry name" value="UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03649">
        <property type="entry name" value="UPF0014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="35512" checksum="4D98FCB1FC3291AD" modified="2019-07-31" version="1">MDPGGPEQTTHLNWGNVGLAFSFVLLNGVLSTAFGLGVGSGLLTAAIRCVVQLSVVALILQKVFETQNPAVVAAMAILLNLMGTIETVVNKSKKRYDWMFVSVFLGMLGSTIPVSIVGARFAMGIQPFWKPEQYIPIVGMLCGSTISGIVVSVTYVLKEIYDNRDKVEMYLAFGASRFEACKPVARDALRLALTPNINQMSVIGIIAIPGMMTGAILGGSSVEQAARLQMVIMFMISSSTALASIATTILALGVVVDAQHRVRTDRIDTREHAVWRARNWALGRVVAGVRGAAYEVVGLFRWGRGGRRGRRGRRGDEGGRAEDRERLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6F8</accession>
    <name>A0A4Q9Q6F8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_945607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6F8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6F8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="165" mass="18835" checksum="6259A2D86D38E70A" modified="2019-07-31" version="1">MLYSRPSFVPHSAKIIVGLPPKRRSAAHKHRRALSLTVLWYSDVLNRFYPAWRSSAEAGTGVGIDPDPRRQMEHARHLAKHVFPGQYGLRSAFCAGPLGKHASSRTPDGAHREQEIKNKGPCKTPKRLKHVLDPLEKMVWRHRKCKYKMLLDMACPSKVRRACRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6X7</accession>
    <name>A0A4Q9Q6X7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly(A) polymerase</fullName>
            <ecNumber evidence="13">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_916991</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="13"/>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6X7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q6X7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="19">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="18">
        <location>
            <begin position="207"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="17">
        <location>
            <begin position="354"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="520"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="544"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="561"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="88"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU63212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="606" mass="67876" checksum="C7D885CDCEDBBCA6" modified="2019-07-31" version="1">MASTNGYLGVTPPISTSESNPREKEVTVTLLEELRRQGIFESEEEAKMREIVLGRLAALIKKFVKRVSLARGLSESAANSAGGKIYTFGSYRLGVHGPGTDIDTLCVVPRHVTREDFFNVLEGMLREMEGVTEVSGVPEAFVPIIKTEISGIPIDLLFAQLSLAAIPDDLDLRDDNLLKNLDERCVRSLNGSRVINEILRLVPNVDVFRDALRCIKLWAQRRAIYSNVNGFLGGVAWAMLVARICQLYPNAVAGAIVSRFFIIMHRWSWPQPVLLKPIEDGPLQVRVWNPRLYPQDRNHRMPIITPAYPSMCATHNVMASTQQIMTEEFKRGSEIVDQVISGEVQWSALFAKHDFFFRYRFYLQVIASSPDLDTQNKWSGTVESKIRQLVMRLEFVDALKLAHPFIKGFDTVYYCLSEDETRAVARGEIPEAVANRKQEDIAGKEGATTMYTKSFFVGLSIKPKEAGATGPRKLDISYPTNEFIKMVRLWEKYDESQMNIAVRHIKHTALPDFVFDKGEREAAARPKKRSRTAKESPAPSAKRSRMESDTPARPDSESPLKRSTISSQGRQLSTPDSSMSFASMTEHPHTAQTSDAMDSLAVAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q759</accession>
    <name>A0A4Q9Q759_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_916994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q759"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q759"/>
    <dbReference type="OMA" id="IKFSRQN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875:SF2">
        <property type="entry name" value="ACR183CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33875">
        <property type="entry name" value="OS09G0542200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13462">
        <property type="entry name" value="Thioredoxin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like fold" evidence="1">
        <location>
            <begin position="12"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="206" mass="22660" checksum="3A5979C14F685E81" modified="2019-07-31" version="1">MALQPSFQKALVIAGKYDAPHTIEVFLDYVCPFSAKLSLAIDSVLRPLFAPGGKYAGKVKVIFRNQVQPWHASSTFVHEAGLAVARIAPEDFWKFSLALFKVQGEYFDIPTSSLTPLQVREKLAKLVADTVGQDKAAGFQDLLALKSSPNGGTAVTDDLKYTVKFSRQNGIHVSPTVLWDGLIANEVSSSWGEKEWTEFLEKKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q966</accession>
    <name>A0A4Q9Q966_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_945141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q966"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020710790" description="Secreted protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9009" checksum="1A6AC98223C01561" modified="2019-07-31" version="1">MWPSGIYILSPVLIMTPSLCDLSIVLSFPLIQDCLPHVAEAILREPLRASRTEVCSFCVANTGASTRPRFAASRPDPLTAVHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9M5</accession>
    <name>A0A4Q9Q9M5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pro-kumamolisin, activation domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_389343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9M5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9M5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020698420" evidence="1">
        <location>
            <begin position="19"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53 activation" evidence="2">
        <location>
            <begin position="36"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19070" checksum="3FB166C58DBAEE9F" modified="2019-07-31" version="1">MIAAGLLLFSLFSSLALGRPTAHDVFHVHEKRSDVPNGFKYVGKAAPNATLDLRIALVQSDPAGLEAALYDVSTPGNKNYRKHLTKAQADAFIAPKPESVQAVTTWLAKNNVTAQTSATGEWMKIRIPVSQANALLDTQFNEYSHDETGLTVLRTMSYSVPASVKGHLDFIYPATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB65</accession>
    <name>A0A4Q9QB65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Urb2/Npa2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_805510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QB65"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052609">
        <property type="entry name" value="Ribosome_Biogenesis_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018849">
        <property type="entry name" value="Urb2/Npa2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15682:SF2">
        <property type="entry name" value="UNHEALTHY RIBOSOME BIOGENESIS PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10441">
        <property type="entry name" value="Urb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar 27S pre-rRNA processing Urb2/Npa2 C-terminal" evidence="2">
        <location>
            <begin position="1214"/>
            <end position="1443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1444" mass="158762" checksum="B3FC90A3DA179BD3" modified="2019-07-31" version="1">MRGLQNAQDFIRALKAPSDPPHEGGPLKIDIARQAWEDSLLYVPNKAEAISDWLLSRLLKDRSRERSENPVFDTRYWLLLADVLACSSPAREGDPSTRTSRPWLVPLLNRVPVAPIILSYFELLSESDSIDFEQYKLVAWCVSVLWPLAVPKFSPETLLECFGAVLQLGVSSMLSALDGSPGTLQELDHANALSVIVSSYRTSLASSAAKRKQINTLFLQKHLPFWLQLVPADGHGQALLSDVYDAGIETMFGLEVVKQMTDSKYDTALLEALEDASIQSPAVVPCSIPRLFASYVRSVKRHKSALFGQGSSRAPGHILEQVQAASMVFYGTCNTLARKSADDASWQCLVSLLEVVERENVLSVEDEEAHTLLRGDGDLAVEALAVAWDESHASRTDCALKILATLARIDYDLTSAAFAVIYPRLLAVPGSISSALQYLRLLLEYESKTRTLPSAIEHVSEAFSVQHLKRISDSPHTAYQLASAGPLTSLPFLDELSRAVHGFLTPGQVLDTIAYVARTLKDAYGRLVERDARVSAVRGDGPRKKRRKSNAPSSEDGSESEYHAVSFDLIARTMIVVLRSLPLHSLTDDARAEAERSVQDLYHAVASPALAQGLGGPSQLVSRSWQIVVTGALRLHYGLARAPALQLELRLEDELPSAMLQCVPSPDVIPDLVVELLRTMLHQCSLGFLQPEAVLDRLLDYLEMHVAGDTASWTGRVHALHGHDTGGVAVLHLLVDRWLPDFDTWATSKQLERLAAILVNAGRLPHVSQSPIGLSVQTVLSRLLRDAQFWELLTFRDAFISELVEHTAPMAGVDLPDLLSRLAADTTRPSADVVSQIAWAYKVLLLIPAEYLPRATHIEFLKRGFAADVTVYLTLRYAKSWLSEQDLLVIRKVLRRTIDHLGLIENVISKEFMGYLLEHGINGEAVNDASRDLRLATMNLVDMYQGSLVRLAKKGKADSVVELAHRYAEAFDSADAKINFEASSLLIDSLVQSASPSELPAPCIDSLRNLHKSMLNYSLPRLGLGSDDYTIPLDRSLLDIWFHSRILGRWLDVDDVRIPVIGRQLSRRLLSPVGSKENISSLGSVVLSILLGELQDAATLEVREGLEFMVVAYLAFARTASPSDITGLESQLASACKTLSTDTFSSLLDLVYDGLPLHKGLSSPDVARLIRLSSILLRDAPEGTAKICQSHTTQCLNLFADDEQFTTDPCLRGEVLDFLARQCGDRPASIRTADLSSLWSILRALLSGSTAHEQSTDSTVFHGIVNVLNALVRLRRDLILNTLPHLGFVLRQLVACLRSLRPQLGGKQSRLVMDTLPRWISPSGPLSGQESKALARLLTTLTTKTIVRTHGAAADSQKPESLTRAFSKHAAYVLTAYVEAVNEPLCLVSSGIRKELQPGLFALCEMLGEHTRDAMMVSALDVGGKATMKVLWREYEKQRYVGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBY4</accession>
    <name>A0A4Q9QBY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_913093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBY4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6534" checksum="96E37466DB43F45F" modified="2019-07-31" version="1" fragment="single">MKFPPRASGKPRTRRRSSPIGAFLPQHLEHTSRVFMLLYLTVVVALVLEAACSSPQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC94</accession>
    <name>A0A4Q9QC94_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RhoGAP-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_913166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC94"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC94"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF134">
        <property type="entry name" value="RHO-TYPE GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="5">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="4">
        <location>
            <begin position="388"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="734"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="816"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="856"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="856" mass="93747" checksum="66570D1787E268F1" modified="2019-07-31" version="1">MSSTAEAAAAARVVSGDAAQSATALFDTHLRLLNESYLAFFIERKRIEEQYIASLMKLHLKSKSLDAFMDDRVEHSTTRAAWIEIVDNVEREAGAHRALADSVYVDVIEPLNNFKEEQERIRKRIREDVKDAITAHSDYAENTLPRLKRNYIKKCQEAEEYRSAAVVSPTSPQDPNVLPPLSKAPPPQNPNGIRPVVTGPQPLRPLERRASQNVHRNRSPSASTSTALHDLAHQGKRQLNQLMTFLDKGGNVRDGGRSDNALRLVRAKREAEEADKEYRKGVHWLETLRIRRVKILESGFKSLESFVRESSETMRKVLEVYTDSLTAAAAIQGQLCEHGRQMVEQIVPQQDSAAIAASIRGMLSLLTPKPTYYYNFNVGECKDLIFGVTLVDYATARGLPEGDIPKIVRICIEDIDRRGLEAEGIYRVSGRHAAVQELQHKIERNEAAFAFNPTTDDVYSVASFLKMYLRELPEPVFKFPLQDRIQHTEGIDEHAANNFSLLRSKIRRLPAIHQATLRALVEHLARVAANSDKNKMDPKNLAIVFGSVIFGEDEMPKGGDILGMQSWKDTLMEDLIVNAHILFQQSGSSSPPLPSAPLNEPAAPVAYGSQHTKVLSSMPPPPVPASPRKGHKKSASTSTVRSSLDVPRPHVPQDFTPQLPPRPANSIHPSLRAGPHAGSPARQIPSARAGQFFDDDMLITPQTSISSREHGSSTSLPPQLPPRPEELSPFFGPTGSSWTLAASAETDASTNVDPVREPSSKRSSRQIPSGEAPRPTPSPIPVPQVQLSDDPPADVFSPPPPSSLRSASHESGIEMSSTAVAAAFASATPSPTSSSHSSAHSSPSKRSAGHSRKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCH3</accession>
    <name>A0A4Q9QCH3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trypsin-like cysteine/serine peptidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_943850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCH3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCH3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13365">
        <property type="entry name" value="Trypsin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="Trypsin-like serine proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31699" checksum="6107D45C5D5918D9" modified="2019-07-31" version="1">MKRAGHVLDTSLPYESRPDAERRIQFTQDERGVEASNADGALAVVTHAAHDRTGKHKVTYSMGFAIRSPGLPDGEAAFVTCAHTLEEIRHDPLVRTTRPSSAAALEELRSGSFVISDTTAAAGPAPTFSRVSSVLSAMHRGDLLLLSTPQPRLPPAPSPGLRSLPVNPYPVHPGAAIRAHFVADKPPSGADRDGWTPWVGGTWRKWVRGAVVGYRDYAGREAKPGTYDSLAHLHFEPPPTPGSSGGPIVDEESGSVIGVVLGTQLVNQVEGVRGWGVPAEMIFEMFSLPGLKLKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCP7</accession>
    <name>A0A4Q9QCP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CENP-C homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_911307</name>
        <name evidence="9" type="ORF">BD311DRAFT_744217</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the kinetochore, a multiprotein complex that assembles on centromeric DNA and attaches chromosomes to spindle microtubules, mediating chromosome segregation and sister chromatid segregation during meiosis and mitosis. Component of the inner kinetochore constitutive centromere-associated network (CCAN), which serves as a structural platform for outer kinetochore assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CENP-C/MIF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCP7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCP7"/>
    <dbReference type="OrthoDB" id="1939643at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019237">
        <property type="term" value="F:centromeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051455">
        <property type="term" value="P:spindle attachment to meiosis I kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06993">
        <property type="entry name" value="cupin_CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000033">
        <property type="entry name" value="Centromere protein C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028386">
        <property type="entry name" value="CENP-C/Mif2/cnp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025974">
        <property type="entry name" value="Mif2/CENP-C_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16684:SF11">
        <property type="entry name" value="CENTROMERE PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11699">
        <property type="entry name" value="CENP-C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mif2/CENP-C cupin" evidence="8">
        <location>
            <begin position="478"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="571"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00057947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU35568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="621" mass="69417" checksum="EC7C5015CBA79FB9" modified="2019-07-31" version="1">MPASARKSSVGNLRRAPQKYIPYRADDFQHGKKTGIAVAYVDHTDEFEPFEKVMSQADQRTPFRPQGARKKRGPKTPVPVPEEQFDDDDGNGEISMELDDDTPVGPGAYFAHTRVNTITSSVQRVGSSSRPVAHNSDVDFDAVPSPRASPTYTARRAAPNGHGRTSVPSRLSQSMVAAEDDDESDVDAGAPKYDYGGYGDDMELDDSPPPPPQNPRTPRSGQSSRRTSFANLDQEASEDERQAVENDMDFGRSPSEKARGKQRASAVYQDRDEEMEPEIAQGLGDIEQEPMNDEQEGSVLEPEETVLEQPRGKKGKKVTNSKRKENEGAARGRPRAKREVLREVTPDDSNAEGLRRSKRRRYSPLAFWRLEKVVYGRRENGPCLVPSIKEIHRIPEIKAEPLGARRRRVGGRKKGRSTATAEPEPQQVLVYDPEEGWDDETDPHCKVLEFGTDGKEVERRVAFTAKMITPKAAAQGAFYFQKIFGDGDYLASGVLYIPPNSTKPTKSTKDNTFVFFVIQGAVKFCVHQTNFILATGGMFMVPRGNVYYIQNICDREARLFFAQARKMPEDYREDTESDYEERSRSKSVGGQRREASRRASSETVNGDAPEPRKQRRGTSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCX0</accession>
    <name>A0A4Q9QCX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine phosphatase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCX0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="274" mass="30552" checksum="5096F071C1822BAC" modified="2019-07-31" version="1">MAIDRIYLARHGYRMNWVTEDWVSVTGTARDPPLAPYGLSQAKELADFFISLPEEERPTIVLSSPYHRCLQTAQPTAEALKLPIYVEHGLSEWYSPAAPGTGLYPRPGQATDLRTHVPEISDDWQSIFYPTRKGEDAPEMHDRSHDLLRALIPAVEHKYGGKHQRILLVSHAAPIIGLVRVLVDNRALPLRVGTCSITDLRPRDTLSNAVGNWEAIKLADSSHLEEGALRDWGFEDAVYIDGKVINHHGEPGTENEKDEPVGLQVHLLPPGFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD37</accession>
    <name>A0A4Q9QD37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_911917</name>
        <name evidence="8" type="ORF">BD311DRAFT_744750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD37"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD37"/>
    <dbReference type="OMA" id="IDHGFNA"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006101">
        <property type="term" value="P:citrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010109">
        <property type="entry name" value="Citrate_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01793">
        <property type="entry name" value="cit_synth_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR610109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU35863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="461" mass="51159" checksum="2881D010FEBA5DC8" modified="2019-07-31" version="1">MFRSGAVSSARQFSRGFAQRRLASTKTVREVLEEVVPQQQLRLKQLKTEHGQAVLGDVKVEHVVGGMRGLKAMLWEASVLDPNEGIRFHGLTIPDCQKALTPAPGGKEIIAESMFWLLLTGKVPTEAETRQLSRQLAEKGDLPEFIEKLIDSLPPTLHPMTQLGIGVAALNHDSKFQAAYERGIKKSEYWTYALEDSLDLLARLPALAARIYRNVYNPGKPLPKINKDLDLVGNYVNLLGFGDNHDLTEYLRLYIAIHGDHEGGNASAHTSHLVGSTLSDPYLSYAAALYALAGPLHGLANQEVLRWQMNMQKELGGNIAPQDIKDFLWKTLKSGQVVPGYGHGVLRNPDPRFIALQEFCDTRPELLADPIVQLVKKTYEVAPGVLKEHGKTKNPYPNVDAASGCVLYHYGLTQFKYYTVIFGVSRALGCLTQYVWSRALGLPIERPKSLSMDAIEKLIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD79</accession>
    <name>A0A4Q9QD79_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hamartin protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_864785</name>
        <name evidence="3" type="ORF">BD311DRAFT_20669</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD79"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD79"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="483"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="930"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="691"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="895"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="605"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="937"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU35906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="955" mass="107462" checksum="C8903771B3357331" modified="2019-07-31" version="1">MSSSPTVADLCTQLRLLLESSPDAISINEILARVDSFVLECSASQEASTLLYQLEVELEAVYDEVLCHALFPRVELFLAFLYHLRPVLPSIAIISTWFDLVLRPTLREPKLPLPAVNYAKELIITALDPGNNFSHSDAEDANSEADKQKERVGDFRRRLVDLYLLDAYNESSGDDVLEWAELDQDQRERKACWKSNLEDILVRIGLERPKDFFTELYHCFILPISRLQLLTLLNAYTSHPHFPAHADVLASHPLMTSLLHSLIFDNSSTVCTIALTILSKLLPVFAVKASGHLKSLLPLLLVVLARILCWKERPPWTPLLPASPETDDTDAEDAAASGDDGLNPREGARPLPIREDLDWTRLELTFDGAPSGAPSVHRYFTFLYYLFPCNTIRFLRFPVKYLNDSGLESVYALDWDAALDEEKVRSKSERLLRGHVLHPLLIWREPQEELEKPDFWSNYDIPQIVGGATMLDVRNAALGLRQQEQQGPQPVGASQPSEQPPSPQYERASRPPSIAEPMSLVAEAEGGVDAAAPLSSSVETVHLGPELHSPDTPAAAAPVRLKVSLSEMVATSVALRSGFDVEIVDAPSEWSTTLFPLQPRTRSPSRNDGESPQPREEGGEPSPGPTPSDKATQGDGTVPAHVAQAISALQREILLLRNDLNLELWTARENVAHIGRLYKDRVLSRNEEAERQGLHNKLKEYKHMVTRLRRELKEEKDQAVTQRLRYTDWNRELQDRIAALRAEKKKWTSEAASMRAAEKEAKDTFAAQGKLLADANQLVFRLETQIKENAHKVDRLHDYETQIDQLIKLQRLWESDVQKLNDSKEYLTAFASKYRKMELRLEAYEKTLGQMDASAAVQRQQILVLESEVKHCKKQLETARRSSVHNAHAALPTELVKARETHERLRRENDELREEVEELNAMVEELKGKVSGRTGLIGSPRVGSPISPRSSPPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDY1</accession>
    <name>A0A4Q9QDY1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">mRNA-capping enzyme subunit alpha</fullName>
            <ecNumber evidence="3 16">2.7.7.50</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 16">GTP--RNA guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 16">mRNA guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BD310DRAFT_804767</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the eukaryotic GTase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="3 16"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDY1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDY1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000011">
        <property type="entry name" value="mRNA-capping enzyme subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017075">
        <property type="entry name" value="mRNA_cap_enzyme_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036959">
        <property type="entry name" value="mRNA_cap_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 16" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="19">
        <location>
            <begin position="126"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="370"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="N6-GMP-lysine intermediate" evidence="17">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="TBU65560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="444" mass="51249" checksum="4FE3582264C98F3F" modified="2019-07-31" version="1">MVRIPDLPGNPIPHRTDQELWLKRHVAFLCRLDNERFPGSQPVSFAAKDLDKLEAQDYWVAEKSDGVRVLLLVHTDMNTSDQMCYLIDRHNTYRELPGLFFPHHEDPRKPLRDTIVDGELVVDVDPRTKQETLRYLAFDCLVVDNQNVMSRPLDKRYGRLQKWVWEPYRKMMRDHPHMALQQPFEFKVKDVKFSYHVEDVFNIDIPQLQHGNDGLIYTCVSTPYAPGTDPNILKWKPPSENSIDFKLVLRFAPTPGKPAAPDFQTKPIFELHVWCGDDRGVPRYEFYDVMHVEDDEWESRMKMSSEQLDERIVEVHWDPELEHWRMMRFRDDKPNGNHKSVVDNIIKSIADGVEKDVLLSRSSAIRNKWKARAAAPGGGGPPPPATKAAHPLPLKPIQHALPPPPPPVRAQRPDAPRVEQRYSRLAPSPWSKVTGPAMVGGIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE75</accession>
    <name>A0A4Q9QE75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_911788</name>
        <name evidence="10" type="ORF">BD311DRAFT_783443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE75"/>
    <dbReference type="STRING" id="114155.A0A4Q9QE75"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000004">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002111">
        <property type="entry name" value="PRK00951.2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002114">
        <property type="entry name" value="PRK00951.2-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU35814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="201" mass="21784" checksum="CE7825D86AD2A149" modified="2019-07-31" version="1">MAARTATIERKTNETEIKVAINLDCQPGTGNKQEISISTGIGFLDHMYHALAKHSGMSLQLSCKGDLHIDDHHSAEDSAIALGTAFKQALGEVRGIRRYGTGFAPLDEALSRAVIDICSRPFCVTDLKLKREKIGDLSTEMFPHIFYSFAIAAGVTLHVDVLRGENDHHKAESAFKALALAIREAIQRTGGDDVPSTKGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFC0</accession>
    <name>A0A4Q9QFC0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="2 9">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_865270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="2 9"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFC0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFC0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.120:FF:000035">
        <property type="entry name" value="Geranylgeranyl transferase type-2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="39860" checksum="C3C1444CF2A68D24" modified="2019-07-31" version="1">MHNVKRVRYSAEALAAQRQREKARLKEFQSLTGEVLARKQRKDHSREAFDLTTRLLQINPEFYTIWNYRRLVLLNGIFVESTPTQINDVLSDDLSLTTTLLKQHPKVYCIWTHRQWCLAQVPDGPTASDRNGWRQAYWNKELFVAEKMLEADPRNFHAWTYRRYVLAQMPVKRPETADLAFTKRKIESNISNFSAWHQRSKTLTSLWDAGKLDKARSLEEEFDLVRNAMYTDPNDQSVWIYHRWLVGPGEFVIGDDKGLLEREVSSIQELLDIQPDSKWCMESIVFYKKLLLRRHGDSLGDDERGKLNSECEELLGSLQSVDPDRHQRYVDLSRNHHIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K0L0</accession>
    <name>A0A4V2K0L0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_959801</name>
        <name evidence="8" type="ORF">BD311DRAFT_693257</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143414">
        <property type="protein sequence ID" value="TBU29323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K0L0"/>
    <dbReference type="STRING" id="114155.A0A4V2K0L0"/>
    <dbReference type="OMA" id="MKAQCQV"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU29323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU57013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="12253" checksum="F750E70B23E6EA4B" modified="2019-07-31" version="1">MAAIAPARLAALTRMRCEIFQTAYNPTSVRTGAKYLRARLRGPSMIQYYPDELSVARFNRMGGDFKIQDWDEYQRLSDVEEKKRRGKGAPKKAKSPAESRRQSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K643</accession>
    <name>A0A4V2K643_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_911974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K643"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6917" checksum="ACC34BA8CFDFB070" modified="2019-07-31" version="1">MSTTSLPVTMRPPMPASCTSPHILRAPSADSHQTPTSLDARRTWLKVAADRIYWRGPQVRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6F0</accession>
    <name>A0A4V2K6F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Acid protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_1001160</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145282">
        <property type="protein sequence ID" value="TBU51843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6F0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020402111" evidence="6">
        <location>
            <begin position="21"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="7">
        <location>
            <begin position="65"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="305"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU51843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="42806" checksum="274A7CF81994B1D3" modified="2019-07-31" version="1">MRSALALGVLALSASSVVYATPKPVPVTLQARKTPKGHVNGLRRRALSAIGVHLDDFFRGTDLQWFGNISVGTPPQPVSVVFDTGSQTLEFASTDCSSCNQTGKFDKSKSSTFKQGNDEETLPFSTGVGVDPVVDDDYVLTVRSATDSVTVGNVTLKKVSLYTIVKQTPKFNIDPFLGIQGMGSSAEGFFAALIRDGLDSLFSLFLTPEAVGNAELLIGGIDDSKFKGDLIYTDQTGSGDWVASSSSISINGKTTSVLNQQRDIIFDSGTSNILFSTETTEAIYAHISKDIKPFDAEPGAYGLPCSKIGGLPAVIDITFTSQSGEPFNLTIPSSELNVGPFDSDPSTCQTLINAFDGLDLVGGSVLKHYYSVWDVGNQRLGFAPNAVNSCQITHALAFGYCRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6I9</accession>
    <name>A0A4V2K6I9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase II subunit A C-terminal domain phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_940556</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This promotes the activity of RNA polymerase II.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="ML145257">
        <property type="protein sequence ID" value="TBU52313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6I9"/>
    <dbReference type="STRING" id="114155.A0A4V2K6I9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011947">
        <property type="entry name" value="FCP1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02250">
        <property type="entry name" value="FCP1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="155"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="591"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="381"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="684"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="773"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="892"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU52313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="928" mass="101441" checksum="B70C572A0BB99FA6" modified="2019-07-31" version="1">MSSPTELKLPTTLPYPIKLLSLAAHPNTEVQRGTRLLDYSFAYVNPDGRTESRFGTWDSPLDGTLTRWAFKKGEVIQRSRADASPAVYILEPCKHGIVFGGLCGICGKDLTRSDYLGSQIDQGGATIPMTHDRDGPTVSLEEAQRIERDTAQHLYRSRKLSLIVDLDQTIVHATVDPTVGEWIAEGEAWEARQAKRAAAAAAEKEEGEKEDADADEDEVNPNWEALKDVKKFRLGPEALGQPHQRGSKGKGKEKTIEQDGCMYYIKPRPGLLDFLQTMATKYEMHVYTMGTRAYAEEVCAAIDPGGKIFGNRILSRDESGSLTQKSLQRLFPCDQSMVVIIDDRADVWEWSPNLVKVIPYDFFVGIGDINSAFLPKLEPLAPAVPPPPPPTTAAVDADSGDDEGDVTLVVPNDDDDEDDNDNDAEDTDAEDDVLEASDRPSSPPADDELSEARKDEMLSANTLALEAQVEERPLAKKQEALLETANGEAEAESSGASVGGADGQNGHAPAAAAAAAGQQERKERPVRKALLKNDDRELDRVQQILELVHERFYAAYEARRREEGAQSPRKKAGRRHDAPVEYDVRTIIPRIRMDTLAGVHILFTGVIPLNQRPETAEIWKTATAFGAQCHTDLGKHITHVVTNKDNTQKVDAARRYADVRIVWLNWLTDSLALWQRQDETPYLLHPAPQGEEEGGRAAAVGSPPSDAHQISSDPDPDADDWDELLVADSSGAGEGSGSRVLGALGVEGPEPAAKPRIALDEVDWAAINDEVEEAMNESDDEEGGSVKSVDDEGSWTDETNSIISSTTSSPRMKRKRVRSLTPSEIGSLNGADSDVLRSPLAKRKKLAADRSGASRLKEAFTAEQLRGVASRRTSENGSRKGSRRSSPVNAIGEDDEDDTDEDDDEDGTSDGNMIDDDFLARELEEEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6Z6</accession>
    <name>A0A4V2K6Z6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_828632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6Z6"/>
    <dbReference type="STRING" id="114155.A0A4V2K6Z6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15766" checksum="5FD51D1A4F5840C5" modified="2019-07-31" version="1" fragment="single">AEGATAIEPTGEAVEGAYELWKPVLEKVEIFASLVEDIGDLHPYAKIASKILLSVVKPVIDQDKRDNAMADLLEAMNELYGLVNKTGRLSDLDEYRRRLLRDMSSKTEECAKFIQDEARFTNFCEVSRRVLATMRTEAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K750</accession>
    <name>A0A4V2K750_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_729829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K750"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="219" mass="24395" checksum="1CF6CECA74E98016" modified="2019-07-31" version="1">MTTTASKTIYSPIPRQASTGTMLNSYSIFSPPVQGLQALRRPPVLSPLRQPNSPQIRRLLYKVVVATISQRLYRSKSPVAFPSPSGNPLQPLRSSLTTTLRHGPISVPFALQNAQQRLSHISVEDRAFGRRPKPSRRGKRLVSKLSPLYENDTHTLPPTIHNLTRQKTTLSRSRVSAVENTIPFPTETPPRSNSIPKGRKMRAVSYSVPRQPFAQLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8K9</accession>
    <name>A0A4V2K8K9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_947379</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="11">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8K9"/>
    <dbReference type="STRING" id="114155.A0A4V2K8K9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF15">
        <property type="entry name" value="TRIPEPTIDYL-PEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021032667" description="tripeptidyl-peptidase II" evidence="12">
        <location>
            <begin position="18"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="13">
        <location>
            <begin position="202"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="11">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="522"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="523"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU60438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="602" mass="63173" checksum="F2446343438E7064" modified="2019-07-31" version="1">MLAAGLLFPSLISHVLGGAVPRSDLIPRSQLPSIPSGYSPSELWVPGDDVIRLTVGVPPKDASSLHATLLDVSDPSSSNYGRHLTKDEVAQLSSPDPESVKAITDWLGCYGITPEQRSHSGDTLSIVVSSVRANALLAANFTAYTHNTTNTTIIRTLSYSLPAYLYDHIAFVYPTTQCVGLQLSSRRKTNQASAFSTSCTGVVTPKCLQALYGIPSLPANASGNSLYVSSLGGTGANPNDLQTFLTKYRPDILHGSFAVLPITESQNTDAGDDEGNCDTQYTVGLATNVPVTYVVAGDKENGVLMSDLLDTANFLLSLEKPPLVLTTSYVFDEPAADDQDLQQMARAICNAYAQLGARGTSVIFAAGDGGAAGGMSASDGCGQKVFIPTFPSTCPYVTSVGSTDDISPEVAASFSSGGFSNLFPRPSYQDSAVNAFLDKQRNANAGLYNSSGRAYPDVATQGVDFAINVAGKGVGFSGTSASSPTFASIVALINDRLLASGKSPLGFLNPMLYSKGVAAFNDVTKGDNGDARCDAGGFNADTGWDAVTGLGTPDYDKLLDVVTGHSFNKLHSGAARVPSISRLLYTIIWMFTAVVVYRHIAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8N5</accession>
    <name>A0A4V2K8N5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_975753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8N5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="25369" checksum="4873301838F7E292" modified="2019-07-31" version="1">MANPASKVGGRDSPNVQVKPASVLPPLFPIHEEDAGYRSQEELPASVTSTPCMLPSVVDRETFMPASSDFETFPDERSGEVSQPDLDVHMGEVSQPVLNVGVGEPPLQEHPPAESAQVEVGKGGEEMTDERGGDGAQAPGQKKRGRPKANVAPSTRVLRGRSQGNPDTDATATVDVGSVPSTQEEEKRRRRGVERWEWCYPGHGDPWDRDWRDGDPGDRQPRGHGWYFPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MDH0</accession>
    <name>A0A4Q9MDH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">TAP-like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_228970</name>
        <name evidence="6" type="ORF">BD311DRAFT_809255</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143462">
        <property type="protein sequence ID" value="TBU25390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145248">
        <property type="protein sequence ID" value="TBU52514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MDH0"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040683950" evidence="3">
        <location>
            <begin position="27"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="94"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="432"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU25390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU52514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="583" mass="62099" checksum="5C59330BF125F12C" modified="2019-07-31" version="1">MAIAERAASAAWKHNVVALLAGGALAFAGSTTSVGPVQGNVGDISWGNCTDNSTLPGAECGYAVVPLDHTNSSAGVAKIALGRYNATASPRKGAVFFNPGGPGGTGVYLATQLGASFQEFVGEDYDIIGFDPRGIGLSEPQTKCFTGNGSRQAFIANTVLDRGYDVSPNLTDPFNRYHLIETQRDANALYQAQFQVCAQTMGETIKYAGTTSVVRDIDYINTILEGNNSLINFYGFSYGTVMGQYLVNIFPDRVGRVVIDGVADADSWANKAPYQQLPVWLNSTDATYKLLYSECAKAGPTACALATKENEDPNDIFNRVEDWIDSLYETPLAVPNATLPGILTNGRARLFIEGGLEAPLGWPQIALGLAEAMLGDGSTMLNAVNEKDLVDLERSAVSCNDQKPFGLLKPETVVDAGLAALQSVSRFFFSVLVAEPDSGCQYWPVTPPERYLGPWNHTLNNPILIVSNTHDPVTPLVNGQAVHSYLADSSGLLIQNSPGHTSQALQSTCTKQHLRAYFANGTLPTPGTVCEVEESPFPPPSNSTASSIIGSAAIATSANSKMRISDTIHRITPDKLRKASGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MJD4</accession>
    <name>A0A4Q9MJD4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_940713</name>
        <name evidence="14" type="ORF">BD311DRAFT_699131</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="ML143451">
        <property type="protein sequence ID" value="TBU26046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145260">
        <property type="protein sequence ID" value="TBU52240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MJD4"/>
    <dbReference type="STRING" id="114155.A0A4Q9MJD4"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000003">
        <property type="entry name" value="Tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU26046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU52240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="445" mass="49795" checksum="E333F38E7698A889" modified="2019-07-31" version="1">MSADPATESSTVPPHPEQAADSGPPAVKPALTAEAQAQVVTPWDVQGGVTEDGKQQAIDYEKLLVQFGTKKIEPELLERFEKVTGHKPHVFLRRGMFFSHRDLNTILDRYEQGKPFFLYTGRGPSSDSMHLGHMIPFVFTKWLQDVFDVPLVVQLTDDEKFLFKHELKVEQTYEFAKRNARDIIAVGFKLEKTFIFSDYDFVGGPFYRNVSKISRQITINQAKATFGFNDSDNIGKIHFASIQAAPSFSNSFPQIFGSASNIPCLIPCAIDQDPYFRLTRDVAVKLKYPKPALIHAKFFPALQGPQTKMSASDVNSSIYMNDTPNQIKSKINKHGFSGGQETVEEHRRLGGNPDVDVAYQYLGFFLDDDEEWKQMGEEYRAGRLLTGELKAKCIKILQDFVKGFQDRRAAVTEDDIKAFMDGSRKIEPTFGKSKAAAEAAAAPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MN62</accession>
    <name>A0A4Q9MN62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_937421</name>
        <name evidence="2" type="ORF">BD311DRAFT_326894</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143422">
        <property type="protein sequence ID" value="TBU28348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145206">
        <property type="protein sequence ID" value="TBU53722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MN62"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU28348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16487" checksum="E5BB77B83D7D1B89" modified="2019-07-31" version="1">MVVIVDFGTITSGQWPLYTWGLAKSKPNHCPRQCASTLARKATLRDPESAQQYRPLYASKTLRCGTRGATCARVENGHVRRPVGAKHSWELHSGARLHRLRTARACATLPSSLRRTARYSGAPSRGTRASSRASDFDRPPHPDVRAGKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MXT2</accession>
    <name>A0A4Q9MXT2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_807636</name>
        <name evidence="3" type="ORF">BD311DRAFT_803593</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MXT2"/>
    <dbReference type="OrthoDB" id="2734989at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU32904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9143" checksum="F8637D742E3EB153" modified="2019-07-31" version="1">MSGDEAQQHIYQVHGLALNPINCGVCGWTFGALGRYAAHQWLHVLTKPCTQCGINFRSAHDRFAHLCERHNLTTENAHLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N1P2</accession>
    <name>A0A4Q9N1P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Lanosterol 14-alpha-demethylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_1041034</name>
        <name evidence="13" type="ORF">BD311DRAFT_686782</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N1P2"/>
    <dbReference type="STRING" id="114155.A0A4Q9N1P2"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11042">
        <property type="entry name" value="CYP51-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000033">
        <property type="entry name" value="14-alpha sterol demethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU32626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU55545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="544" mass="62508" checksum="8E022C3CC68DD5CE" modified="2019-07-31" version="1">MSVNATFSEPWTGTLSQLEWPDTPRLWLLALINIPLLSIVVNALWQLIPRPKHQPPLVWHWIPFLGSAPAYGRDPVTFFRNCREKYGNCFTFILLGKRVTVTLGTQGNDFVLGGKHSQLAAEDVYSHLTTPIFGKDVVYDCPNEKFMEQKRFVKVSLTIDKFRSYVGMIEDELRDYLNTDSAFRTYQMNDINEWGAFPVLKTFSEITILSASRTLQGREIREGLTKDYAQVYSDLDHGFTPLHWMVPGLPLPSYRKRDAAHLKMSSFYQSLIRNRREHPEREHEDDVINSLMQQKYRDGTPLLDHEIAHILIALLMAGQHTSSSSIAWTMLHIADRLDIQEALYKEQVEHFGTPDGGLRDMRYEDIRELKVLDAVVRETLRLHPPIHSIMRQAHTDIPVPATLAAPSEDVKYVVPKGDIVLASPLVSQVDPAVWDEPEKWEPLRWYDEKGVAAQANKQYNEGEKVDFGFGLVSKGTVSPYLPFGAGRHRCIGEQFAYLQISTIITALIRRMEFRIEGEFPKPDYTSMMVQPLPCQIMYRRRNFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N3N2</accession>
    <name>A0A4Q9N3N2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Spindle assembly checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_869052</name>
        <name evidence="8" type="ORF">BD311DRAFT_649698</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N3N2"/>
    <dbReference type="STRING" id="114155.A0A4Q9N3N2"/>
    <dbReference type="OMA" id="WQFDVEI"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU34805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23955" checksum="D831A0DCCF33EE12" modified="2019-07-31" version="1">MPPTKQKQAPTRQAITLKGSTALVTEFFKFAANTILFQRGVYPADDFHMVKKYGQTVLVTQDLALENYLDKILKQVNEWLLTGSITQLVLAIISKDSRTPLERWVFDINLVEPPAGSSEPYVAPPKPESEIQAEIRNILKQIVSTVTFLPVIDEPTVFNILAYTKESADVPADEWVDTDPLAIEASKSQQVKLRSFSTDVHRIEAMVAYRYEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N574</accession>
    <name>A0A4Q9N574_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_974706</name>
        <name evidence="4" type="ORF">BD311DRAFT_746104</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N574"/>
    <dbReference type="STRING" id="114155.A0A4Q9N574"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23164">
        <property type="entry name" value="Prefoldin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20903">
        <property type="entry name" value="PREFOLDIN SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU34412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="122" mass="14078" checksum="4E87988A3FE433E2" modified="2019-07-31" version="1">MATLSDDTLRKILVQIQQTAVQSQRALNVSKQQIAAKERERRILQLTIEEITSLQGDVNLYKGVGKMFMNVPRPTMEKELKAEEKELTDDIKNLEKKSKYLEKQFNDAQAQLRDIFQSAPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N6S6</accession>
    <name>A0A4Q9N6S6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_963871</name>
        <name evidence="12" type="ORF">BD311DRAFT_745420</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N6S6"/>
    <dbReference type="STRING" id="114155.A0A4Q9N6S6"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="53"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU35012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU64828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="145" mass="16439" checksum="DD632C5B2A5A404C" modified="2019-07-31" version="1">MSQRYRTNAQSRSQLLGPPDYSTPPSSGRSSPLGAAVAGRENPFAPMGQRYADDLESQNDEHLEGLTAKVKILKDITLAIGSEVKDSTIQLSQMNDAFSETSGILAGTFRRMNNMAARQGCRWLWYIVFLIVVFWFFIVVWWFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NE40</accession>
    <name>A0A4Q9NE40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_549575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145136">
        <property type="protein sequence ID" value="TBU57532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NE40"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="238" mass="26688" checksum="38FFFD4F72FA57B9" modified="2019-07-31" version="1">MGDCTYSGDSWSLRFPCLRRTQSGGSRAYLWFARGGYPHPPFRRSLLAMSICLIYRQHRNVNPVVPVPFFRFLGLPRVAPGSLGSTVFVPSIHRMPLRFVVKHRRKNLVSHCLVRFHLYTAASSLSSPASVHFQRTHHCTTITLDFTYLVDRRRRTLLRPKRAAVLSATLLSPLMLPSSPRHPSYAQHIHDMRSLGASCVGSCRQADGGVDGQSGDDRLGAAGWRRARGGTVVWIVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NF83</accession>
    <name>A0A4Q9NF83_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_935333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NF83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043332910" evidence="2">
        <location>
            <begin position="21"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="461"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="535" mass="55790" checksum="A08A9A7FFB6132E0" modified="2019-07-31" version="1">MAIIVLSPLTLALICFTVLAFVTGCAVTAAALVSRRQACPSSSTVVDVEAQPQLSVCSTSTEKPQDSTTASITSSKEPCELTPTSLCATSIRIPALDTNPDKVSMSDDSMLGSSEDAKATSRHGTAYETPEQDRYTTIPRRSSALAKAKAKARARQTLSLLREYGISLGTPNDSGLCNDVILHGPPEPTVAVEEPSSDPRALALADGRLTLTPEATTTSPELPSSNIKELSPALQVSSSASLEHFRTSSEPLSASVASTPSLTSAASTPSNTTSWEVQTPPTTSIAGSLRYDSFPTLKSLEMRSVPVDAVVLAPAGVLLASGSFPSCVSGISEIFLSGRDLASPTYGTDEKLVSDSPKGLGFDVTTSALPVSSELGVSSAHSSAELAEAQGPLYSASPSYNIASHGDTTFNVSLASDADTAWDMDASEMKSTISKRYSDLLDALTTSFSITSLKDPRSNRSSMSSVSASSSASSAANLPDPNSGLDLYYDASESDMDSSYSSEASEDVFQADPERLANHTLHESCSYSMHPVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGN5</accession>
    <name>A0A4Q9NGN5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ferrochelatase</fullName>
            <ecNumber evidence="7">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_829424</name>
        <name evidence="8" type="ORF">BD311DRAFT_754985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="7"/>
    <dbReference type="EMBL" id="ML143407">
        <property type="protein sequence ID" value="TBU30226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGN5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NGN5"/>
    <dbReference type="OMA" id="DPYHCEC"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000001">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 7" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU30226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU53760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="38909" checksum="2ADFFD5685C021D0" modified="2019-07-31" version="1">MLNMGGPSTVPETHDFLKNLFSDGDLIPLPFQSILAPIIARRRTPQIEKQYEDIGGGSPILKYTKIQGERMAALLDELHPATAPHKAYVAFRYARPLTDETAREMKADGVKRAVAFTQYPQYSCSTTGSSLNELYRKGKTGDFGDGVEWSVIDRWGTHSGFIEAVAQNIERALEKFPAEHRSDVVLLFSAHSLPMSVVNRGDPYILEVSASVNAVMDRLGHANPYRLVWQSQVGPSAWMGMQTGEALKGLARLGRKRVVLVPIAFTSDHIETLYELDLEYAKEAREHGVEVHRAESLNESPVFIRALADLAAAHLKNHSGGKIGPTSVQLGLRCPGCTNATCGAQKAWFARAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIM2</accession>
    <name>A0A4Q9NIM2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_828715</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIM2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="256" mass="27879" checksum="00ABF558393FEEA1" modified="2019-07-31" version="1">MSSNAVAVSPEEMSSLLTSGFCVCAVFAWLAYDWLLCFGEEIQLVWNWNSRRTGASLVYALSRYMLLLQNLLAVTSIVPMSTLRCAPYCPFMFLCASLMAELSCNAVAWMQTVTAVIGTFAPGIFSAMRAYALSGGNKYLSALAALLAIGPIVAQLVSSIQYQAVKNFPSPFNCSTVDRASPSLDWTLSLLSVTLAQRVPWIASDALVLATTWWFAYQSYRMQTGGIHGQSLSSILLYNGTYMNICSTSLALTSRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIV0</accession>
    <name>A0A4Q9NIV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_948968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NIV0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="293"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="305"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="458" mass="50271" checksum="A9742825AF714700" modified="2019-07-31" version="1">MRPTAATRTPDFTGLVLDGRYKLTRMLGSGAYGVVYEAIDKKSRVNRHSPSVAVKLISKTTPTHNGFSHTPLEISLHARASKFPNVVTLRRTLDDGEHSILIMDLCPGGSLGDHLVDRGAITDEQMLRTMFLDIVDAVVNLHQDGIYHRDIKPGNVLLGEDGRQVFLADFGMASRIESYNERCGTRAYMPPELLHSKYNQRPSAAHSDVWALGIVLLNMIIGIAPWSRASSSTRKYAEFVHNPRYLIERYQISPGLNKIIRRMLRANPRIRMRLADVRRAIAELDSFFCNEADGGNDDLTQDMPEDGRAAACPRDDGPPDDALTGHKPTQGAHAGPSPYTNHGPSKRGETIAEMMRSTLLAEIDILRASRTKPPMLEQRAQDCSAGLSLGLSPYMSAGGRNEGLGVGGVCSRASSGQTSRSSAVVATPEDSEAVVGKREIGQRMRSIVTRVKMKFRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKM5</accession>
    <name>A0A4Q9NKM5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_931374</name>
        <name evidence="6" type="ORF">BD311DRAFT_756855</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="ML143414">
        <property type="protein sequence ID" value="TBU29273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKM5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NKM5"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032787">
        <property type="term" value="P:monocarboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU29273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="27731" checksum="8D285C22982BCDDB" modified="2019-07-31" version="1">MSETQAEYPLQGKLALITGCTGGIGQATARAFARNGCSIAVHHSSARSKAKADALVLELIKLAPGVRAAAFEADLSAYDNAQTLCDRVTDILGHPDILFSNHGVTGPRIGPEGDIQNVSAESFEEIWRTNTGTGFVLVQKCLPYMQEKQWGRIIFTSSVAAGTGGVIGPQYASSKSALHGLIHWLSLRYCKEGILTNGVAPALIEDTDMMANPTDAIRSKIPIGRLGKPDEIASIVLMLATNGYMTNKIIVADGGWTNGGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPV2</accession>
    <name>A0A4Q9NPV2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_878795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPV2"/>
    <dbReference type="OMA" id="TAMEVEW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="219" mass="24597" checksum="91C002B22ED5825C" modified="2019-07-31" version="1">MALASDPKSVIRLLTYALVFMTAVNVVFLGIIVNVFDKLVPPPRVYSYIGDDFPSQLPVKLPSVGLALNNPAPHFSLLSDEEWGAQYPGETVGFTDLGPMNRTFFPSMLHQMHCLDVIRVGMATNRTGFARHVEHCTRYLRQIVLCNSDVTLEPAYREEKDGDWMWAADGINSIHRCKDWTVVRKYLEEHPAKSPVPPADGKINPDETYEHVVKLKGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQ02</accession>
    <name>A0A4Q9NQ02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_836287</name>
        <name evidence="8" type="ORF">BD311DRAFT_772707</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQ02"/>
    <dbReference type="STRING" id="114155.A0A4Q9NQ02"/>
    <dbReference type="OMA" id="MPIRTEG"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU35630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="132" mass="14177" checksum="FFE56A3505062D1E" modified="2019-07-31" version="1">MAIFGLWVINKAGGLVYERSFGDGLPHLTSNEYLVLAGTLHGIHAITSRLSPTGSSSGAHVISGETFKMNILLTATGTKFVLLTSLVEPSADSVLQKVYEIYADAVMKNPFHTPEMPIRSEGFDTRIVALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRM5</accession>
    <name>A0A4Q9NRM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_949874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRM5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11591" checksum="5A6C69C0D02401EB" modified="2019-07-31" version="1">MNLPMLQPGTVWWNGQANGQNASPDDYVRPAVPNASVASTGLITASLDLHVPDFSTLRISDDSPDAIAFDVDFPFEDFKLVVDHMHESSLASERDFAVRFDPENAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWR4</accession>
    <name>A0A4Q9NWR4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_922389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWR4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NWR4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="250" mass="27515" checksum="5C14C1A34A1573AB" modified="2019-07-31" version="1">MEVDMTPVPYRTRSTTKRARSPSSPTQYDRPSKRFSSGHDTSMPFPPSSFHPVATRLRGSPEDWVSQTQDLRLGSPLEQSRVGTPVEVQGEEVRIDEVMVDEPMCENDNAMSISPTRRSSTLLETPQAQYLRPSGGSVYLRSGTTQSFQNPNQLQIPAIHVQAATPSPVQLAPPNILNDDSLPVSGSPFAPAHNLGVPLAPSPLSSMPPDESPHPYTTPGPPKKQRFTMGPRADCEMCRTRVKGHYMHFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NX06</accession>
    <name>A0A4Q9NX06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphingolipid C(9)-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.317</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_886037</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.317" evidence="14"/>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NX06"/>
    <dbReference type="STRING" id="114155.A0A4Q9NX06"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052290">
        <property type="entry name" value="Sphingo_C9-MT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197:SF1">
        <property type="entry name" value="SPHINGOLIPID C9-METHYLTRANSFERASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45197">
        <property type="entry name" value="SYNTHASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU54516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="483" mass="55113" checksum="8267A0662CB93ADB" modified="2019-07-31" version="1">MSSYSVKVTDTPAIKNAPLIGLAEGNGYFSNAQLAALVLGVPWLVKRTLPVLCYGGFKTYVFLVLLLGIPITAAYWTVMSTYGPRINQKVQLPGRNIEEYITIKDPELKAKYFGKEKIPMQVFHDAFFDDKVEFNGDVLDILEARHDWAKMVFTPELFKYVLTQMLPEVILHTKSQDEEQVRDHYDRGDDFYEWFLGPRMIYTSGVVRDITTEESLEQLQDNKLTLVCEKLDLQPTDRLLDVGCGWGTLAAFAHKNYGCEVTGITLGKNQTKFGNKRIADNGGDPSRARILCLDYRDIPGGRAAYTKIVSLEMAEHVGIRRYGAFLRQMYDLLDDDGIFVLQVAGLRPSWQYEDLIWGLFMNKYIFPGADASCSLGWVIKQVEAAGFEVKNIDVLGVHYSATIWRWYRNWVSNKDKVIEVYGERWYRIWVFFLAYSTIASRQGTAAVFQITLHKNLNAYPRILGVPSHTSIHVHPTREIHSIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXI5</accession>
    <name>A0A4Q9NXI5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_932163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXI5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NXI5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="58"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="522" mass="58775" checksum="4BF8B2378C725256" modified="2019-07-31" version="1">MSDVSDLTDFDDEEDVPLSSQKTMKSKAKGKSNAQSAYRIRGALRAPRATTYTCQALYDQIHAQDIDLQPEYQRDVVWPESKQIGLIDSIFRNFYVPPVIFVVNTMDDGGERRVCVDGKQRLTSIYRFIAGEIPFKDAFSGEKFVFKDTGKIKAQVLPDHYKKIFLNKQIVCMEYTDITPDNEREIFQRVQLGMALTPAEKLQAITGPQADFIRSLLDKYVSDELANNLPWDTSRANDFRGLSMAVYTMSKWPKVTTLPSLSVIEAWLQEPDELDDDFREDLHNTYRIFCAMAKDPVLNKPFWLPGIKKVAPMEVIAITVLIHANKLKMTMAQLSEAIGLMRKEIRKTEKDIRQNTRTMKLVLTFLKELKPSRLKPDPNSSKAVDYPSVSSKPKSKRKRPAASDAEDEPRPSPTVRLPKTSSQPPPSTTNTPTIPPPSFSPYPPPPTAPAVLRTNGSGHPLPSRPHVPIPPQISAQRQHTLSENYTPRAMAGPSTQAYDASRDPRNPAYQLPPGAGQTWPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYJ2</accession>
    <name>A0A4Q9NYJ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_961666</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145198">
        <property type="protein sequence ID" value="TBU54035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYJ2"/>
    <dbReference type="OMA" id="PKYVGAE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="350" mass="37268" checksum="04C9182504209E25" modified="2019-07-31" version="1">MATITTPITEMFGIKHPILLAGMNVAAGPELAAAVSNAGGLGVIGGLGYTPKILRQQIKAIKDDLVDKSLPFGVDLLLPQVGGNARKTNYDYTKGQLPDLLDVIIEEKTSLFVCAVGVPPKWAVEKLHKAGIPVMNMVGHPKHVEKALDAGCDLICAQAGEGGGHTGDIPATILIPACVDIVKGRKSPLTGKPIYVIGAGAVYDGRSLAANLSWGAQAVWVGTRFVASEEAGAPKAHKEALVGAGYEDAITTLIYTGRPLRVRRTPYVDDWHNNRQEEIKELTSKGIIPVEHDLKQHPEKSLQARAWLIGRVASLIHDVLPAKVIVENIVNDAAKILQENAAKVSVKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P008</accession>
    <name>A0A4Q9P008_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Arabinogalactan endo-beta-1,4-galactanase</fullName>
            <ecNumber evidence="3 6">3.2.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_809376</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>The enzyme specifically hydrolyzes (1-&gt;4)-beta-D-galactosidic linkages in type I arabinogalactans.</text>
            <dbReference type="EC" id="3.2.1.89"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 53 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.89" evidence="3 6"/>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P008"/>
    <dbReference type="STRING" id="114155.A0A4Q9P008"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031218">
        <property type="term" value="F:arabinogalactan endo-1,4-beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015926">
        <property type="term" value="F:glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011683">
        <property type="entry name" value="Glyco_hydro_53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34983:SF1">
        <property type="entry name" value="ARABINOGALACTAN ENDO-BETA-1,4-GALACTANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07745">
        <property type="entry name" value="Glyco_hydro_53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033913" description="Arabinogalactan endo-beta-1,4-galactanase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="343" mass="36932" checksum="5B4BD6E60AF9F1C3" modified="2019-07-31" version="1">MNLLLPLLLLSFSWLASSLNFHGADISSLTVVEEAGVHFKDNGKALPFETILKNHGMNAARVRIWTAGQYNLQYGLALGKRIKDAGMTLIVDLHFSDTWADPGHQSIPSSWPTDLDGLNTQIYTYTQNVTRSFANQGTPIDILQVGNEINNGLLWPVGEVSSAGYHPLSELLHSAINGAKSVASPKILIHLANGWDWSGLDSWFSNVYVPGALSADQVDIVGVSFYPFYDAGATLSALKSSLTNFTKNFGKPIVVAETDWPVSCSGVSLTEPSIPVSASGQQTWTNDIKNILAGLPNGRGQGIFYWEPGWVGSANLGSACADNLLVDSSGNTRTSINIFSQDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P069</accession>
    <name>A0A4Q9P069_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_533644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P069"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16414" checksum="2373E710D128457B" modified="2019-07-31" version="1">MCPIISPRGSSPKVVSTKERFQICRKLAVSSTSDGTTATLICIRPTVLWQNVATRARCQLAKRAAPQRELSALGTEQKVGQGRAAARCPGHLARDCGDSSPTQRVLSAFANVVSSVALRRLGDKDLAQSVEFPHTVPVRCEPVSNANFSVMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3K0</accession>
    <name>A0A4Q9P3K0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_924531</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3K0"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3K0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU59727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="429" mass="45905" checksum="2A6A49ECAC1C65DE" modified="2019-07-31" version="1">MMYSLFSFSLLILSLVAGSTRSLAHPRKPHGADPHNHANASRSSSLVSAAWYAGWHSDDFPLASVSWNKYTHLTYSFAVTTPDVNTISLDGSNPDVLPQFVETAHNNGVKALVSVGGWTGSLYYSTAVGSAENRTAFVKTITDFATKYKLDGIDFDWEYPGTQGIGCNAVNADDTTNFLAFLRELRAHPVGKHLILTAATSVFPWAGPDGNQLSDVSGFAKELDWIAIMNYDVWGPWSATTGPNAPLNDTCASAENQQGSAVSAVAQWSAAGIPTHQIVLGVASYGHSFHVNVSDAIDDSGSLRPYAPFDAALQPTGDKWDDDAGVDECGNENGPGGNFDFWGLIDAGFLTLSGDPAPLTAYDFDVCSQTAYVYHEESEVFVSFDDARAFTAKGHFIKDTKLRGFAIWEAGGDFNDILLDAIRSGAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P439</accession>
    <name>A0A4Q9P439_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_815094</name>
        <name evidence="2" type="ORF">BD311DRAFT_805343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P439"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8089" checksum="93809D6194D1A303" modified="2019-07-31" version="1">MSDILEHQGNEKQFDGDTVTGHFIQKQSIPKRLVKAVGANAKQGNLGRYHLNEANGETQTTDSHSATLSTTYSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4B1</accession>
    <name>A0A4Q9P4B1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MTHFR SAM-binding regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_821105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4B1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P4B1"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.220:FF:000002">
        <property type="entry name" value="Methylenetetrahydrofolate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004621">
        <property type="entry name" value="Fadh2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053806">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00677">
        <property type="entry name" value="fadh2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45754:SF3">
        <property type="entry name" value="METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21895">
        <property type="entry name" value="MTHFR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MTHFR SAM-binding regulatory" evidence="9">
        <location>
            <begin position="303"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU57654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="604" mass="68553" checksum="0CDE415E3E1E19A8" modified="2019-07-31" version="1">MKISHKIEQAAKEDRIWWSFEYFPPRTAQGLQNLLDRIERMRALGPEFVDITWNAGGRSSELTSELVKTCQKLIGIETCMHLTCTGMPKEKVDTALREAKQHGCRNVLALRGDPPVGKEWEAVEGGFSYGVDLVRYIRAEYDDYFDVAVAGYPQTQTLPPAEAAREMQYLKDKVDAGANFIFTQMFYDIDMFVAWVKAARAAGITVPIVPGIMPIQTWNGFQKATQLAKITVPQFFLDELEPHKNNDEKVRELGTKLVAKMCRQILAADIGIKGLHFYTMNLEKGCRLLLEELNLVPRVEVVKPLPWRQSLTPNRRTENIRPIFWANRTRSYLSRTENWDEYPNGRFGDSRSPAYGELDGYGIWIKQSKEDALKLWDTPTTVEQIRALFTKFCLGQLSALPWSDTAPSSETTIIAQQLAKLNELGFLTINSQPAVDGARSDDRVHGWGPANGYVYQKAYLEFFVPPELLELLIPHIERDINITYYVINARGDLRTNTHSEGPNAVTWGVFPGKEIVQPTIVEAISFMAWKDEAYELGRQWAQFYEPDSSSRQLIDEMMSTYYLVNVVHNDYKKPDAIFEPFFKAGAEYAAKHTATNGTANGTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6B1</accession>
    <name>A0A4Q9P6B1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_805877</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6B1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6B1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU65011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="451" mass="48967" checksum="CA8BFB256184E885" modified="2019-07-31" version="1">MSAPLTPNSSPRVRRRGSTRRPRAGSHLPPFTQESHDAALYAIRTYLKGRTSYDTFPVSFRLIVLDSKLEVKKALQCLLLNGVVSAPLWNSDKSCFAGMFTVSDIIHLIQYYYRSSSYDAAAADVETFRLESLRGLSVHLSAIFPCNHSHIDTDIEKQLGVAPPPLLREHPSASLYDAAKLLIQTHARRVPLLDVDSETGHEVIISILTQYRLLKFISINCGREIQQLHLPLRRLGIGTYVSAPPLPPDVERPEGYNPFHPIATATMNTTVFDVVHMFSEGGISAVPIVDEEGIVVNLYETVDVITLVRLGAYQSLDLTISEALNQRSPDFPGVVICTASDSLGTLMQLIKKRRVHRLVVVEGEGRLLGIITLSDVLRYLIGDVYIGESLPDPPPAPSEILAPPPSGTAPPPAASSGPEAAAPSDEAPANPAPAGDTVDTAPEEKAAEEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6K8</accession>
    <name>A0A4Q9P6K8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transcription regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_912867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6K8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6K8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU66150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="395" mass="43925" checksum="40DF55CB644D8DCA" modified="2019-07-31" version="1">MGLFNRKKGGDDEGAKKEKGSWRRPANTAFKQQRLKAWQPILTPRTVLPTLFIIGILFAPIGALLIWGSGLITEIDLDYTDCELLTSQNASNTSTSLTFTDIPSSKYSYKLRASDSGAPISTPQYAFLDQSGASGVSNDSARQCVLQFDVPADIQTPVLLYYKLSNFYQNHRRYVKSLNSNQLRGDHVSYGTIKGGDCKPLDVSNGKIVYPCGLIANSVFNDTFSNLTLTSDTSTTFTWSEKGIAWPGESKKYATSPNYQLSEIVPPPNWAQRYPQGYTEDNPPPDLKNDEHFQNWMRTAGLPTFTKLWGRNDNEKLPKGRYQIAVNLNYPVRPYKGTKSIVISTVSWIGGKNPFLGWAYVAAASLLVLLGVLGTIRHLVKPRKLGDMSLLSFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P732</accession>
    <name>A0A4Q9P732_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_836227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P732"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="14"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="120" mass="12916" checksum="1DEA3F348672AC25" modified="2019-07-31" version="1">MAQSASQNGLYAVADFCLIPIGTGEPSVAEYIAECVRVLEKTGLKFKMHGYGTNLEGPWSQVVQAIHDCHAAVHAKGASRIATDIRIGTRVDREIPPGTGNESKVQRVEEILKRAQATSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBY1</accession>
    <name>A0A4Q9PBY1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_809953</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBY1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="317" mass="33795" checksum="783610AE5429B5BC" modified="2019-07-31" version="1">MPTVPSTCVPVNALDSVVIPEAGLLPPDEVTSGPTPDPDTDDVMLVQTDDGMILEASPSQCPPQTIAKPHRIELGSLILHSPSSIVGTPFDSSPRFEYPFPPAGDVIDQLEPLVPSFHILSPSFASFPPPTPSLPPPLPLSFPPSATPAAKPRPQSRCFSPTHLKLNAREPPVPPGLRHKIIRDNTGDSTTMISVMGFDIGGATSLNQPSRSRRRSGSLSGLSDKLRLLTQTPIDPSGVARAKEAARIGAKPPQAHEVDNKWKRHSLAICESDREHDTDDATGGHPGHDVIADILRGKSRGRMRPTLTHSASSMSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PC27</accession>
    <name>A0A4Q9PC27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA polymerase III transcription factor IIIC subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_921226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PC27"/>
    <dbReference type="STRING" id="114155.A0A4Q9PC27"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="7">
        <location>
            <begin position="51"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="6">
        <location>
            <begin position="236"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU61332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="564" mass="63586" checksum="51A46D22FA41AE82" modified="2019-07-31" version="1">MDIDPALQAGPSNLNAGPSTLPSQAEKTSESSAQASPPPAPQLPLPAAHFYSVEYPGYVKPTSAPLAIERLGGQHAIDAAFRRATGRDRVESLLELRLRPGNPYAHPIPGEVVHTSNIVLKVVKRRRKRKDGDPGDGAIGEYTVEAVGVVPKTARFRSMADFQYQPDMADPIAKLRNAMDAMGVEGILKYHIPPEKEDYTITTTQADPSAMDIDPQLLGEGTSSGTTVRTKSNLRLFPPPLFSRQGVPQNYNYKANTASIEDIIVDKETGEEKKRLINRMRWKGFAPISVSYSDKNVPDKPSAPVEEQRGQADKNILKKLEELFQERPVWTRAAIFNQFMPLEVRDIINTKYLLPLVSYVFEDGPWRDTYVRLGYDPRVDPEARFYQRLYFRNVNHPIVRPSVVTRRQEQRNESAQVRFSGMDGRRSHVFDGQVVTSETAAFQLCDITDAMLKEMIEADDEDSLREACNERDGWYTTHALERIKTVLRHKFFSLLLGHVATREECEALLVPHEGTDKLPQRHRHRLKFGKHNMAKGALPPEDAAAQRLMTTIEQQRKSLKFTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDG7</accession>
    <name>A0A4Q9PDG7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_888645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145232">
        <property type="protein sequence ID" value="TBU52900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDG7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDG7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="618" mass="69048" checksum="475856019B5C167E" modified="2019-07-31" version="1">MSTMPARCHLFSLPAELLENVLIRCSADGHPLSVAAVAQTCRQFRTLVYHAADRHLWRALFLTTFDDPRLLAHLKSEIYWQREFTERIWAARVIQRSARTLTVSTKKRALRSTSAMMYPIDGFLEETGNPDKHARVLNALLTVMRTACPSAPHQIRPISAEPTAGQPPVPGLTRAHARTPVYPPPVPSQASSLNIAWLKDTLSRGLPFSITQIISYDTLAVEWYTMPEGQALCQLTAYLDFLPIPLVDPDIDDATPSTSYRQRKPRKSPVRRKGLKTAEMIDMSEEAQRARARQHARPHAFDMGYLSRRRHWGPYLAVRRQRGGPSEPVMSDVEADLDEDTDTDYDADYVPPDDASTSSATPEPAAAPAISALPSPEELRPDWTWLAAARIVAQCKLRQHVNAEDIAKLENWDNLREGAWIPEPQQPSLEADGTSEENPLQAEATQSKEPDEEWKRYERDWAGAEGVWRRLVCWLDYDDLLYHNSYGAFLDADLDEAWIIVPMSLRITGYSAPSLPHLYPDRPTIHVEGEMGGAGWVGSVDVGDNDIRRAYGTVSMLPDGEVRWSITSSAPGSNEDEWASEAVQLGGVGSAMGALGMWTGAFHEDGDPLGVLWQWRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE92</accession>
    <name>A0A4Q9PE92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_998025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145251">
        <property type="protein sequence ID" value="TBU52425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PE92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="2"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="313" mass="34472" checksum="7F0D010E4B9905CE" modified="2019-07-31" version="1" fragment="single">SVVFLYDSIITTGEEIQCFWGRKITGAAILFWLNKYMTVLCLIWNLVTALNISDKYYNHLRSRSCSLSVRGDDIILYLLFIIPAAFTTIRVYALRRSFTLCALTAVLSLAPLGINFFADFGLGISGKNIPPFGCTQIGNVSIDLSQKFTIITRSCLIAADCLAIGVTWSTLGLQYSPRERGMLKGSISSVLLTDGTIYFLSLALLNCLHLAFTLLSISVDALQPISVVSVFTTPLSALLESRFFLHLQSASLQAVGSIPSSQNSSLHLDRSLVFERVVGSLAASIAPENYYREDFDDGDYVERAEEPTQTSRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFC2</accession>
    <name>A0A4Q9PFC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_980934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145208">
        <property type="protein sequence ID" value="TBU53639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFC2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PFC2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="893"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1031"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1031" mass="117813" checksum="40F7A4D1932A4B8C" modified="2019-07-31" version="1">MTPISEDDAIRLPPDSFNARLIIDYLNHQLHVHHANTQFKRINQSSFDYYVHNSLAYAWESFACKQKGSGSTLHFTFGTPELRFICDHDALLELTVQEVTSDDDSVEDMSEALRGAKLAYRVTTTRRTIVGNDFTVGDHESRINLLVCDLEYAELIHPRNEDIVITDGLQDLLGLYLNALQLGGHHVFFFPPQFDEADYYRPPRLSLASDYVELTKQFGPSLTTDIQGFSEARINAHFSLTWGACMFAAREHRSPLRWNSASALAEYQTWLFEDLDSEIEWHSSMKFREPRVTILCAREIVLYFTLSEVRFYEARSNPTGLPEKDHPDNETPWVIALIVDVQATKDSLRIIAETARYSEEFSEITGLNEEHKDAYSDLTEFFVRRYIKLIASRRIAYRFRDDYSVISTAGFDDGSWWMLERESGTSLSVFSSTIKHTRMEGFDVVIAISQTTINSQFTQLFKGYHSELSVRDQLHYKVEVKTITVQLLQPKGFQESGSEALDESDQAADDEEATTNLAHSRAVVTVHVSSGSLHYWLDEDFEKISRPDHISGKVGEWRLAFEVDLAMCYNDELPEWRYRHQPFVYPPPPGEDSYRVRHVYLDLQNARFSPRYSTMEDWEYGIPNVIRARMTLAQFIKDDYFPLLIEKSVHIIASIPIFKPGSSSTFYKLTDITCRTYAVESKRADEGDSASYSEQLLFILGMTGYRSLPDITRFIPSTQWLLRGRFSHGTLAISKSTFRERLHALLGNINALTTLVHNSSASYMIKDVVQRWADHPDYRKKPSEWMPVNGTDSRAATKFAWHFENEMHLKQGTQLITHRNYEIECSTHNELELSDVSMLSTGSLEIRIAGVIRLRMYSSRADSSWETESSVPWNVIIRIKTAAHGNVEVDIDGVDNLRPTPPKSTIRSGGANVPNMQATLRHHLPRRKDFEEVMKELKVLQGVWRYYYPATTPFTLCTPMLNNDGDFLFELRRSQTDVSQRVGRRRGRVAKLTPTTPTTPTSAGSSGPDGYKVTPPRQASNESSNANDNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGH7</accession>
    <name>A0A4Q9PGH7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_952002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145211">
        <property type="protein sequence ID" value="TBU53535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGH7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="6875" checksum="51D95FB0B7C5A7BA" modified="2019-07-31" version="1">MDPDNEKVRICRDYAKRSAASQPPPRHSLLTSPQSLSRTCSSSSSILLSASALSASSSVHPLPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGJ3</accession>
    <name>A0A4Q9PGJ3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">HSP70-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_889527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145254">
        <property type="protein sequence ID" value="TBU52372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGJ3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGJ3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000012">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000028">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="519"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU52372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="546" mass="60383" checksum="9B01BADE58699978" modified="2019-07-31" version="1">MPPGNLSFAKLCIPISPPQRFAQFSDPDRIQSDVSNVPFEIFEKDSKPYIWITENTPLVAGRGVLLDYDEYRRSCSLDPGLNDHLESAVITVPAHFHLSQKQATKDAGTMAGLNVLRVFNETSACAIGYSVDYRITSERHILIFDLGGGSLSVSLITVEEGVLWVNSHAGDAHQGGEDFDDRLVQHFSAEFKRRHKVYLSGNPRAIRRLRIACERAKRTLSFAMKTTVMVDGLYGSIDFETSLTRGSFEELCEDHFHRTLDPIDRVLPDAKFNKSQVYEVILVGGSTRIPRVRRLVSEYFDGKELNRSMNTDEAVTRGAAIEAVIVSGDTSEETQDVLLLDVIPVSLGVETAGGVMTPFIKRQTTFPTKKAEIVTTYFDNQPGVSIQVYEGERARTKDNNLSGRLVLSGIAPAPRGVPQIKVLFEVDQNGFLVVRATDMGSGKSNEISIPSDMWTLSREETDRSAARKNLEADASSLETTVAELELQNALSRATLLLNADNDISAAVYRRRQQAMQVAAEAEMRKLSGSATSQQGERSGRRVSDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH22</accession>
    <name>A0A4Q9PH22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_831803</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145243">
        <property type="protein sequence ID" value="TBU52631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16177" checksum="A5D767729BEBE4D0" modified="2019-07-31" version="1" fragment="single">PLHAALLPPSSLASVGAIRNGAEVSSFQLPVAPATPQLVPPPVTAFTGKAGKHILVEVSDGDDTRSGEVDRVTTLVMHKRVWRTADAGGFGVGVEDATMRETAIPIHVEELDGAIASHEPAHGARSTHAHGTDVHDDLEALSDGSDLTDLDELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH34</accession>
    <name>A0A4Q9PH34_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_971021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145272">
        <property type="protein sequence ID" value="TBU52006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH34"/>
    <dbReference type="STRING" id="114155.A0A4Q9PH34"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="357" mass="38635" checksum="8C25F2ADC022C694" modified="2019-07-31" version="1">MSISEIASEMSSVRLALGCLLVETLLCGGFIALHAVIVWQFLSRSSPHARSKRDILLIGASAVMFVLAILHLVIDLDILVQSGLLRGVDVATLAKGITTWNGQTKLGFAKLTIYILQTFIGDSFMIYRAFIIWNNSCYIIAWPVILLTGEVASGFSSLAIGQLSPPARFHAFLQAYLVIAVVTNALATVLVMRPLWSSRGEVSEYRPDGFRLRTVRWRVAKSIVQSAAVFTISAICFTVNSFVSPLGLSASHYIFPPTVAIVFTIAVARICLSTVQESPRPSALEMNYNGPRIQSCPSLPITVDDIEDYSALPIAIHVSVSRTSDHGSMSSCGPHSSASSAKGKDEKYVVEENPGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHH5</accession>
    <name>A0A4Q9PHH5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_994333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU53102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="114155.A0A4Q9PHH5"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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    <proteinExistence type="predicted"/>
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        <location>
            <begin position="255"/>
            <end position="362"/>
        </location>
    </feature>
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        <location>
            <begin position="399"/>
            <end position="469"/>
        </location>
    </feature>
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            <begin position="277"/>
            <end position="289"/>
        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
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            <begin position="437"/>
            <end position="452"/>
        </location>
    </feature>
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        </source>
    </evidence>
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            <dbReference type="EMBL" id="TBU53102.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="513" mass="55918" checksum="8B8602A5F32D282F" modified="2019-07-31" version="1">MDPNSVYINPGAHYSSSLPSPLPAPTHSSIAALETSLRLEIMDLRRQFLELRIQVEEMKRDKTSEAAPVDGDDSRATLKRLVFESVKATHALRPEEPLGHDEVREQHKFPNVKFFTGRHWTSWKRDNKKTTRIGEEPVRGKKMSAQGVNHTAHYVEHIDGTPAEGDYINDARKFCRTFINLARGTQYPLPKKWGDADTWLQDLFYTALRKKFPLFQLCHNNSKGEAFMAYTYYEAVTRKWGKASSQPVHLNKALHTIGSPSDSEESESESVRDVHTSGPSARPTSNKRPSGNDEVVAGPRKQARTELGVARDVVEAPPAPSKPAKGKERADLGLLHVAPPPSILPPTDTSPTSTSAAQSAASASTSSMATSAQFMQAPPVALSPLASLTTLAMVSGATGVIPSPPSPPTPTNPNVPAEGGVDISASPPEDVTPPGTAPSNEQPSKPVETTASKKPRAPRKTMQWPPAPDLKGAKWVYARKWYMDAHGTLEAFEAHYKTLSSSDRRKLGRVAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
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    </protein>
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
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    <keyword evidence="8" id="KW-0804">Transcription</keyword>
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        </source>
    </evidence>
    <sequence length="1440" mass="162819" checksum="C0B7644C17F220D8" modified="2019-07-31" version="1">MLPSASACSISSSAPTSFGLAALPYRTTRSSRRYGTSSRICSSDRGQEQAAGDHSHPGVNGQASMGPIANGVPATNGNALTAGPVSNQLYPQAPQTPVSFTPDQINALRAQIHAFKLISRGMPVPEPIQQAIRVPNQAIPDIQTLLHGADVNARVIDSAVKIHKSTNGTPVNGVVEHPPVAEVTPAPPETIKEEEIEAVDPEKLPKGPLLEEDVNSGIYPYNAYTHPFTFLKRDPDVSPALWATKMQRLLVPSVMPVGLDPHQVIEERNAYIDARIEQRMRELEAMPAMMGDGGLENPLEEAENAEPQSLEQPAYVHPPSNTHGKLRALIELKALRVVDKQRQLRASVAERLMHGTLLPLNRADFRRTRKVQLRDIHNTEVAERKQRMDRERRAKQKHIEQLGIICTHGREVLAVGRAAQERVTRLGKAVLSFHAHTEKEEQKRIERLAKERLKALKNDDEEAYMKLIDTAKDTRITHLLKQTDAYLDSLAQAVVEQQRSEGHEAVDYDMEEGPVSEATFGAKAFSQEEDKGKLDYYAVAHRLKEKISAQPSILVGGTLKDYQLKGLQWMVSLYNNKLNGILADEMGLGKTIQTISLITFLIESKKQRGPYLVIVPLSTMTNWSSEFAKWAPSVKMISYKGNPAQRKVLQTDLRTGNFQVVLTTYEYIIKDRIHLSRMKWIYMIIDEGHRMKNTQSKLAQTLTQYYHSRYRLILTGTPLQNNLPELWALLNFALPKVFNSVKSFDEWFNTPFANSGTGDKIELNEEEALLIIRRLHKVLRPFLLRRLKKDVESELPDKVEKVIKVRMSALQSQLYKQMKKYKMIADGKDAKGKPGGVKGLSNELMQLRKICQHPFLFESVEDRVNPSSMIDDKLIRSSGKIELLSRILPKFFATGHRVLIFFQMTKVMDIMEDFLKMMGWKYLRLDGGTKTEDRAGHVQLFNAPNSEYKVFILSTRAGGLGLNLQTADTVIIFDSDWNPHADLQAQDRAHRIGQTKVVRILRFITEKSVEESMFARARYKLDIDDKVIQAGRFDNKSTQEEQEEFLRSILEADQEEENEEAGDMNDDEINEIIARSDEEAVIFHEIDVQREREALEKWRRAGNRGKPPPPLMQLEELPECYRADEPFAEPDAIDELEGRGHRRRTVVNYNDGLSDDQWALALEEGEDLQELSERAREKKERRAQNKLLKDIDIVDSPGPDLDTPRGSRKNKKGKGKVPAADFDLGTPASSSKRKRGGGKSTSMTPSLIDDEDDERDTKRRKTKQELPPPIKEKMKKALNDVHKAVQNLEDETGRRRSDLFRELPDRREYPDYYQLIQQPIALSTIRKRISSHYYKNVLDFREDMRLMFNNARTYNQEGSWVYVDAEEMEKVFDAAFAKHIVGSGLPGAPSGSAAGGSSGGYDSALTPVDDDDSRPAPSRSKSARKQVISDDEYMTPSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJB2</accession>
    <name>A0A4Q9PJB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Multiple RNA-binding domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_951615</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM MRD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJB2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJB2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12568">
        <property type="entry name" value="RRM3_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12316">
        <property type="entry name" value="RRM3_RBM19_RRM2_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034482">
        <property type="entry name" value="Mrd1_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="267"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="456"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="575"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="676"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU54177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="831" mass="91361" checksum="2479B77B8FA0D54F" modified="2019-07-31" version="1">MSRLIVKNLPAYLTQERLRKHFETSDGPGGTLTDVKLVLKPDGTSRRFGFIGYKSPREAERAKKWFNRSFVDSSRITVDVVDGAKDAPAPRPNKRPRLGPSPAEVEGSAEASANTKTTKTSTKDRSKTGKHADLTDEFMQVMQPRNKGPSWKDTDPIPAPLASTLKDSGIDAKKSKKLKKGKELPEATEEKVGSADASSTTGCSSMSDTDWLRRHTKSTLDSVDVPEKVFEQSDDELMKDDEEDSDDDNDDETEPLDSTKATILQTSRLFLRNLPFTCTEDEIREHFQAHGDVTQAHLVLDPKIQQSKGLAYVTFAKPEQAVAAYEALDKTSFQGRLLHVLPAVDRKGKVEDDKGEGKKRTVKQDRDAKRKATAGKEFNWAMLYMNSDAVVSSIADRMKISKADILNPESSNAAVKLALAETHVIQETKTFLEQHGVDLSALDPSPSGRRPARSDRIILVKNIPYGTSAADVRALFEPHGELRRVLVPPAGTLAVVEFVNPDEGRKAFRAVAYRRMGNSVIYLEKGPEGMFITDEPIADNESAAPAVPVSATGAAPIAVADETSAANESALSARTTLFVKNLSFSTTPEKLTQVVRHLPDFAFARIQTKPDPARPGARLSMGYGFVGFRTLDGARRGLKSMDGMVLDGHKLVVKWAGRGVEGESTADKEKVKARTTKMIVKNVPFEVTKKDIRELFGAHAQLKSVRLPRKFDHRTRGFAFLEFTTRHEAEQAYATLRHTHLLGRHLVLEWAEEGDVDVDKLRDKAGAGYGGGAEMPGEDKMNASSDPIQSWTPTLVAEKLDQAFFPAGCRLEMACRSSSTNIFSPFLLNTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJT0</accession>
    <name>A0A4Q9PJT0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_936181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJT0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJT0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1190:FF:000001">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="9">
        <location>
            <begin position="169"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="546"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="557"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU54352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="670" mass="76067" checksum="B5C64333763D4292" modified="2019-07-31" version="1">MSTSGLKAIAPVPKASDFLDIVLSKTQRKTPTVIHKNFKISRIRNFYMRKVKFTQDSFDEKLGAILEEFPIIDDLHPFLSSLLNVLYDKNHYKLALGQLRTARHLIDQVAKDYVRLLKFGDSLYRCKQLKRAALGRMATIMKRQNEALEFLEEVRKHLSRLPAIDPTARTLLICGYPNVGKSSFLNKVTRADVDVQPYAFTTKSLFVGHLDYRYMRWQVIDTPGILDHPLEEMNNIEMQSITALAHLKACVLYFMDLSEQCGYSVEAQCQLFHAIKPLFANKPTVLVLNKVDVARLDDLAPERRAMVDEIINAEGVRHVQVSCYTDEGVTVLKTTACDALLEHRVDMKLKGNKVNGILNRLHVAQPKPRDDVIRAPFIPDAIKERKKYDQNDPERRRLERDVEAEEGGAGVYNINLKKSYLLENDEWKNDVMPEIMDGKNIADFIDPDILEKLDALEREEEKLEAEGFYDSESDMFDSDDEREAVAAKSAREKKLISQSTKKAMKNRAALPRTAGLRTLSELTSEMTKAGLDPSRIQERAEILAKVAGAKRKRQREEDEAQMDVDEDAEMGDGGEDEWMDVDGEEAPRLKKAKANSGAVAAKGARHPRSNRQLAGMRDEAQASKAVKLRNLGQRERNMQARAGESDRAIKTKMPKHLFAGKRKMGKTDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK70</accession>
    <name>A0A4Q9PK70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_68942</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK70"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37066" checksum="02A5E0871490065B" modified="2019-07-31" version="1">MALHPAHSQSRHSRKRALARTAGIVLLSSTLLLYTSTTIYMAALAWNATSFSSAVTGAADNLFSVTYDGRESILALSEAADKQSRMLTAALSVNVSRVATVRCAWSAEHCAVQVMIGDAVVWWRACFIWQNRLINCLGPLLLTLTLVFGAVGLALSPAPGGIALTVYFGSNGFVDACAILSFGTNVIATSLIAYKAWAHRRFLKKYLGADGMKSRVFRMLALLVESGIVYIAVLAFSVMYQLNPASYESLQQQGALVETEDVFTYGCLVPVAAIYPTFIIVLVALEQSPIAGGLSKASKTQDPEKLDGITTSTIIFHNSTFRSPDSEDDSNALESGACSSNVVPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNU0</accession>
    <name>A0A4Q9PNU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_932602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNU0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="42516" checksum="08B8E7E6BE18F891" modified="2019-07-31" version="1">MPDSATMSPTSSISLVSREVGANEAALSIITYFTSSESQSSVQLFIASVAFGVLTALVGVALAFLIRQGLLARRSVLLLFLSTLLLYSSTSVYMSVLVWNRLSVSQIMSQATTGITSSTYDADSSTASLERVVGIQSWMMTIAAGTNIIIGDAVVWWRACVVWSNKIVYFMGPPLLALTLVCGVINVHNSETGPTLQLQMLIGVDGFADAFMILSMVTNLLATSLIAYKAWESRQSMKAYFGSDGGAMATWRALALLVESGTIYCAMLMFLAVYQLRRPAQVTSTASAFAQTGWFFTDACLLPIAAIYPTFIIVLVAMKRSPIDRGISRVNGEREAEREAGALSTLAFNHSVVGTASTQYTVDSSVDRLGCQSDSEDVYRSMGSTNIEKSGPIGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP82</accession>
    <name>A0A4Q9PP82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_824435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP82"/>
    <dbReference type="STRING" id="114155.A0A4Q9PP82"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="136"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="380"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="754"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="831" mass="93539" checksum="8292E318E978C4B8" modified="2019-07-31" version="1">MANSVVQLGNDEFSRAFLRPSHINVREKRVSLAPFSLLKHARNMDETEISQLFISAVNRHHLIPGSVLVQNAHKLSCSAAEGAQRGISASIIRSLHVPRRGQAHWADQRVPVYFFPRVPDADPFAGAEKKNENTEAGRERKRRLEQMSEAAERLFSAQHRVFLFMIVIFGRKFRLIRWDRAGMIATPPTDYYEQPGILCDYLRRLSLFDDASLGFDPTATRVLSRDPDFLRMDVAATLNNQDLDHFECHAEEGEVGGPHVFRYVRSMFRDSLSSDWPRYRLQVPDGDSMRDYLVGKPVVHGSNVFGRGMRGYVAFDCRTSCFVWLKDVWRPPEMVAEREGDVLRELNEAGIENVPTLVCHGDVGDQATVTDLWWSRGHATSPTSPDYSSSSASSSASSSSSSSSRSPASSTGRKRKRASRLRSDDGVSRFKSRQAPCPLRCHTHYRVIVKEIALPLKNFQRGKQLTSIVLDCLRAHHQAATNPATMRLHRDISGENILIYPRVRQDKDGRGHSIVWTGLLIDWELSKHRDSEDVPKSLAGGRLGTREFMSVNLSGNLRDPVKISDELESFFHVLVYYSVRYLRSNCNSPKPWLDNYFYFRGFPHDYNDSLKSIAINNHGYLSTLVPGGPLIFDSPIDQLLGTLIKSFRAHYKIMYYKARNRSLTPSSSSSSSAGTESQKAARATLRAAIAAHAMAPMIDLDHNPVFAEYMANLTPNITPDNTPTEEDQLLASRVVDHSFALDFFAKLLCRNDWKEGDRIPPRPTSPPPVPEPVIELESEEPAPPAKRRRKTSPKEKAGAAPPIRVDTAVRRTRSQTRAAAVQKASARRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPW8</accession>
    <name>A0A4Q9PPW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_931888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPW8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="802"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="809"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="976" mass="109519" checksum="A91FAC0ADAF49863" modified="2019-07-31" version="1">MSVSGPTIAPVEEGKLLSESLSTVKIQVQQMKRHLELDQLMDALKSASLMLAELRTSSLSPKQYYELYMAVFDALRHLSNYLYDAHVQNRHHLADLYELVQYAGNIVPRLYLMITVGSVYMSIPDAPVKEVMKDMLEMSRGVLHPIRGLFLRHYLSGQTRDHLPIGDDAGPKGNLQDSINFVLTNFIEMNKLWVRLQHQGHSRDREKREMERKELRILVGTNLVRLSQLEGVDLDMYQKIILPSILQQIVVCKDVIAQEYLMEVVIQVFIDEFHLYTLGPFLSATAQLHPKVNIKQIVIALIDRLAAYAAREAENEDPEETKRQEEAAARRLAEKVKQARGLRHNDEGVSSPVSELTPTLNNEWGSPPTSPVAAEKPQEATSPVVNGNGTAEGGEGEKGGKDGKGKEKEKLEPEPEQVKKFRGVPENVKLFEVFWHQVVELIKARPDLSIQDITALLVSLTNLSLSCYPDRLEYVDQILGFAAEKITEFKDSPDLHHPQTTANLSALLNAPINSYQSVLTLLALQQYTALLTQQPYSTRRTLAHSLVSSVLKNETVIETPEDVNGILELCHVLIRDQQDAATGPIHAQQLGGKDPRRGPYYNEREELAEEQGWVARMIHLFRSENLDVQFEVLQTARRHFETGGDRMRYTYPALITSAIKLCRRYKNREHLEDDWQSKVSTILKFVRQLNSILSSNVEAPTIALRLFLLAAQVADECGFENLTYDMYVDAFTVYEDSISESRAQLQAITLITGTLQGARVFSEDNYDTLITKAALHGAKLLKKPHQASAVNLASHLWWQEVPPEEEPAEAEKEGEKQNGTKEEGEKKAYPLQDSKRVLECLQKALRIANSATEEIITIQLYCDTLDQYLYYLDRGAPAVTPKFVNSLVELITSSIDNIASPDVHPAQRAPPGLLEGVQTPEMITRHFRNTLLYILTKKAAAAAAAEAPGVTPGAAESRWDDVDIVGALLKMGIPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ56</accession>
    <name>A0A4Q9PQ56_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_931241</name>
        <name evidence="7" type="ORF">BD311DRAFT_756749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143414">
        <property type="protein sequence ID" value="TBU29219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ56"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQ56"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU29219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="349" mass="39197" checksum="0DFD82B926335716" modified="2019-07-31" version="1">MLRTVKPKNARSKRALQAREPKEVEDPRVAIFVKGTHAGEKVTAVMKELMALKRPHAISFSKKNAVRPFEDATSLEFWAQKNDASLFVVGQSTKKRPDGLTFVRMYDHRVLDMCEVGVEGWKSMADFKTPKATPGHKPLLHFASELFDTHPRFIQLKSMLMDFFNGEVIDAIHLAGLEHVISISLGPTPPSLNAAMSTLQATGAPNEDLLSLPKVHVRSYMIRLLASGTRVPRVELTPMGPSLDLTLRRHTDADPEMWKQAMKRPKLRKQDVEKGVGKKRKNLDVDEMGDLRGRIHVGKQDLGKLQTRKMKGLKPGREEAVGDDENEGESGRDSEGEDEGRSRKKRREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR47</accession>
    <name>A0A4Q9PR47_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR47"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12108">
        <property type="entry name" value="Hr-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.520">
        <property type="entry name" value="nmb1532 protein domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053206">
        <property type="entry name" value="Dimeric_xanthone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38048:SF1">
        <property type="entry name" value="HEMERYTHRIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="19505" checksum="68E129699C17EAA2" modified="2019-07-31" version="1">MSNVHEEARWNRLSEVMSYYHNHFKHEFNSLYDLADGSYTKRDMSLPMYLRVAIQLCQGLTVHHTIEERRFFPILAKRMEAFRDDEVHLKSHQAIHHGVEALQKLVRKWQDEPSTYDPKAMRDCLDSWREVLFNHLDQEVKDLSGENMKKYWTLEELEQLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRR0</accession>
    <name>A0A4Q9PRR0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_968402</name>
        <name evidence="4" type="ORF">BD311DRAFT_765844</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143472">
        <property type="protein sequence ID" value="TBU24822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRR0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRR0"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="52"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU24822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="271" mass="30502" checksum="EE509D1870638600" modified="2019-07-31" version="1">MAINPNEDTEFNDALRKHGILPPKPPTPRTPSPPPPPTLEEKYADYTAAQLRELAAEAPDDETERLLELIRRKRLQEVRKMEAARFGRVYPISREDYTREITEASKVNEEGDAMERGTGVVVFLYKDGIPHSDRAKEHINVLAQRHPHTKFVSIVGDKCIPNLPDARLPMFIIYRKGEVLNQLVAWGADRERRVEELEAVLILAGAIIPQQRLPPDADKDGNDSDSDLDDLDDDDPSSRMRSASTSVNAKAPKNLRGKKGDESDSDFEFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTK6</accession>
    <name>A0A4Q9PTK6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_928810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF25">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="113"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU57684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="330" mass="34678" checksum="5614C89FF8B601E2" modified="2019-07-31" version="1">MGSSFQPVIAVILLAVLSSVLAVPTSTLPVPQRRQENITPLARTQVSSFKPYTNYASTAYCEPANTLAWNCGPNCQANPSFIPIASGGDGVVTQFWFVGYDPTLNEIIVSHQGTDVSKIVPALTDALTLLGPLDLSLFPGMTLPIQVHTGFAATHASSAPQVLAAVQEGMDTYGATRVTTTGHSLGAAIALLDAVFLPLHLPNGTVMRFVGYGTPRVGDQDFANYVDAQNLTVTHINNKDDPVPILPLILLGFHHPQGEVRIESNGVWNSCPGQDNPSTECSTGSVNLIFNNEFDHDGPYDGVTMGCSSGGATGTAPTGILGLPIPIIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUR0</accession>
    <name>A0A4Q9PUR0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_927948</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUR0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="46"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="575" mass="61277" checksum="92043894AB935D26" modified="2019-07-31" version="1">MSWRANVGDIYTGWLGSLGIRRTTMVARTLAGSLVLLEYLALCFAAPVVQLGSSSVIGRDNFVEGQPVQEFFGGIHYAAPPSGLRRFAPPVFKPTLDVDSFDASNYGIPCPQIGLPLNASEDCLTVNILRPAGTHALSGLPVYAWIFGGGFINGDPSLYNASAIVLRSVQRGTPIVYVSINYRLGPFGFPQGVEATARGALNLGLKDQLTALEWIHRNIQAFGGDPSKITVAGGSAGAISISNLFWNSELSRYVRGAILQSGPPNLLPLVPSTRRDKDWQTFVSATPECATAKPNQTFDCLREASADTLIQALATFSAGNAELFPFSPVLDGNDGLIPDLPSRLLAAGKFTRLPLIAGTNLDDATIFVPAAASTDQDAINFFISYADPSDAGPPPPALTSAIDTLLELYPNDPALGSPFGTGNETFGLGSEYKRVAAIADDVAFTSTRRALAQNASDHRSRVFAYLFSDPQAVTNPSQGVAHGNEIDYTYGVPFLAGEPQPAAALSEAMLDYWISFVVTGDPNDGKGTARPRWGQYASSRPAVLQLQGDNVTMISDTYRETQIAFINSAPTTFNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUS8</accession>
    <name>A0A4Q9PUS8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_503261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUS8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="508" mass="57308" checksum="C270DF6E2F5B9B08" modified="2019-07-31" version="1">MSNYNAFGVFNYASRRKAFRLTEVCHHWRTVTLATTSLWCGVICGCDDLRPPEYHLHLSKGAPLHAIIKGDLEAAENILATYPARIQHLLMMDTTFWSRRYDPRRFLAHVTPDLLTCTLNLQSWPRGPRLPELRYNLFAPGGAERLRSLSVYTAKIIPNDHFPNLRVLNLYDIVGIPSFPHILSLIGRCPLVEEVCVHSDCMPGPSTPDGRWDLVELKHARKIALLFPNSAWILAHLALPLNALVRVDDFILEEQSKWSTLPAPLGPAAPNFTRLRIFPQESFIHDGIVGGLRVELAAAMNAHAGYCLNAIARSTVPSLVRYKTLVDIFDRTDSRFAHITVLWAVRIPMTLSLILSALPTIRVLGVVLNYGDTMIDLADTLRVRADGDLVCPSLSALYISHCQGCGKNLHSLRDTVVSRAQANHRIARVALRCAHTPNEDESTLAPHFAAIRQNVDEFTIIPRIWHSKSRSILPLEWREEWGREDDGVWPDWELFGGPRASVRRDFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV70</accession>
    <name>A0A4Q9PV70_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_819839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV70"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV70"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="21500" checksum="E3A0B9BC05A38E6C" modified="2019-07-31" version="1">MEPERNAFERAHWRFGLERASTWMERPGELVQTRSVWTDKGLYAAYEGIPNGFWETPTYTNDHLVRVGLYGWLPQATNTSLDLAKATVEKVWMGWKAISGTSPCWLCPPAARNGEIEKAFEWLLHLLFEFSDVWMSMGGVRVTTPYFQGSGALLYVIAMMAKGWSGSNRTAPGFPNRGWEMKVEGISQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW80</accession>
    <name>A0A4Q9PW80_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1038826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW80"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="37"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="194"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="647"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="843"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1265" mass="142480" checksum="3109A3399660B08D" modified="2019-07-31" version="1">MAHDEDQGADPPELDDDEDDDEDLALTSSLEPKSCTRKAVRGQLTSYADLLFTVQQRVCIFMLFVIGRRFRILRWDRAGVIVTKSIDYFEDWNPLCNFFWCISRLPDNKLGFDPTATRLFETNPEWEQMDTFATALESDVSSEPRPLEDGELELESEIEDAEGPGFVFDYVRQMFARSLKDPRWPRFKLRVPDSGKTRDYLVGKPTVYASGAIGRGTRGYVGLDVQTGRFVWLKDAWRASYDEMEKEGTIVERLNHAGITGVPTVICHGDVGRQRTATAAWWECKNLRGVKKKFEDDSTDAPAIATDSVHSFQLECPIRRHKHYRAVVAQVCINLKKFKTGRQLASIIYDCFETHRLAANLENNGILHRDITDDNIVIYPGVGMKDGCRQLLWRGILTDWEISKPIAVGVRPRARQPERTATFQFMSANLLNAVGPVSIPDELESFILIIIYYATRYLESNILHDTDVASFLDECFDCYTIDGDAILCGERKLSIVVLNSQSAHRHFTARLSMATSATELDIESFLREFLPAPEPTLPPPGESSYNPFSDLRDADNVSDQALSELFVAAINNHCLTAGSTASPYQPSSQKHPLGSSAALFRAEDSVIGTQPLEFDQAVSIEFHSHRRGIDPFEFKDSKAHARLAKPCKRLFERLSAIAELVFAVQHRVFHFMLFVVGRRFRLLRWDRAGVVFTQSIDYYEHPGVLSNVFRRLSRLTDEALGLDPSATRLLPADIDFLRMDVASLKNPTDIDDNTGSHAFLVGRPVFCANDLVGRGTRGYVALDCKTGGFVWLKDAWRASYVISGTEGDTLHKLNCAGVENVPTLQPLLPPDTHPPSSPFLTASSCTPCSSSQSSKKRKRVEESGFVEGSAYGPRASTKSDCPLRQHRHYRIAVYEVCMPLKEFQHGQQLLSIVLDCLRAHHQAATNPKTQLLHRYISGGNILIYPKVRRDEDGQNPSLVWSGILSDWELSKPVGVQEAASRATQAERMGTYQFMSVNLLTNITKPVEISDELESFFHVLVYYAIRYLHSNCKHVDSWVGNYFHTYAGPGRMLCCGQKSTTIEFTGQLRTRVLEGPLLFHSPMDFVLGTILKSLTAHYKVMQYEAMQASPPSPRPQRKPLREEPYVPVGFVPSTSKYKDHPQVAQWEAQWESETLMDRSPTPEDRELATKVADHEFMLGLLARQIWNSRWRIDDRMPKAQVSDGGTHANAKSRSPETPPQAAPASNKRQRTSGPGRNISLPAHLHTSARRTRSWARTLPIRRGAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWW8</accession>
    <name>A0A4Q9PWW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_817733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWW8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
        <location>
            <begin position="211"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="287" mass="31507" checksum="7B2994D3C304B076" modified="2019-07-31" version="1">MELVAPIDNTFGALLIGNYIGLVMYGTTAYQAYKYFQTYPKDTAILKCLVGSRASGAVTSGENIRPYSSFVLRVYKLPSYFYLVTNSFNPSALLAGSWYVGLMGVVMCIIIFVAQVFYVRRIYLCEPQLSLFVTIPHHSSPPVKPNYRGLVVVLVVLLLGELQSYTAAAIEGSTRYRVVAKADLTRMESIALVGVLAVDLFLATYGKSSSTSVILLHRTRTGFRNTDSLLNVLIAYTVNTCTAINALALGFLIAFPTNMIYFGILTPATRSYTMAVLAVYVFPYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX26</accession>
    <name>A0A4Q9PX26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_905977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX26"/>
    <dbReference type="STRING" id="114155.A0A4Q9PX26"/>
    <dbReference type="OMA" id="ERHNQIR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="18971" checksum="8CDAA993F8857633" modified="2019-07-31" version="1">MPRKAAPAADTNAEPRRSARIKDQPKPETAPKKAPAKPRSKKAPAAEGEDKPKPTKGKKRTASEKDAEDGAPEANGEEPPAKKVKPASKAAAKPASKAAGAKPASKASRAGSAKPASRAASAKPASKASAKPPSSAAKKPASRAGSKKPASKAGAAEKENAAAAAPETIAEEPEAEDAANAEPATEQAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXX6</accession>
    <name>A0A4Q9PXX6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_817314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXX6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="8063" checksum="76A069DE9FE85B95" modified="2019-07-31" version="1" fragment="single">QVFFEPKMRGDYYPYLAELTFLTPQEELGKASLEAHRFVYMYSPLLLQSTLTPTGMFVLRVCRLKSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY20</accession>
    <name>A0A4Q9PY20_9APHY</name>
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        </submittedName>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6034" checksum="8115D266F87F3B17" modified="2019-07-31" version="1">MAYQMGSASSLLHHGPHKSSCLNSPSYPSGSNRAPKTGYYSSNCHCFDWAGLGSSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
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    <name>A0A4Q9PZD4_9APHY</name>
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        </submittedName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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            <dbReference type="EMBL" id="TBU60045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="574" mass="64220" checksum="DCBD8FBA6831E57A" modified="2019-07-31" version="1">MTTATRRSLTDVPDILYNVFHHFDVHAMWYDDNRSAALCDSRRSLAMAARTCRAFADPALKMLWSSLPDDQPLADLLCTLGIGRGDGGWAVRSFLVGANPHGFLLPPAVFGGSRNFCFRFFGFVGLQSMSISIPGDPRTHVHWARFVEYASRVRAVALFIFEGPKWSRLWDELQSAAGGITILPMLYTVTFCEVGSRRAVTPGIFALIPPSVGKLRLPLPPSRLDSSMIRTYFPHIRYMDVQPECGVEDVRMLAGFPTLRCLSISVSFAVLSPNLILPVLGTLVMEGSWPNLTTLLNSAHLPSLHTLSVAGWEGEDNASKLAMDAIQCFHAISRYKSITNLSIYTTYTPQHQYGCVEDDIPEVQGTFDGGLLDTMRPLLSLRSLRYLATRLPDYLVGTESDLSLMADAWPDLVELHLVIWVYEGWSLAYIPRSERPYGGRLEGIAHFARKCPRLRVLHLPAMELAEESLGAVEFPSESHGLCTLVIEKVLFPHGRADLAGQMSELVRRVFPRVASAFAQDQISFEKEEFYFSDDDSDPGEEEEEGQETWGFVKGASGRCDDCTKHMWLRWRVAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0C6</accession>
    <name>A0A4Q9Q0C6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_815433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <end position="44"/>
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            <end position="151"/>
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            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="35881" checksum="73367FE6D6F70D9E" modified="2019-07-31" version="1">MSPFMLYNNTNKPAHILPMPPDRRRGVDVTAHGPASDSGDNPGLAPDDYIVFPLEAFETPGDPGIGIIDDAFALACSVQPQDIELELDPDPSLSFSAGADSFPYTPTHASPTSLTFSWTGGSYASPGGPPPSLSPTSSTFSSEPAASPGPISFSPSYSQGEYCVPPPIAYSPLTSPPFYPLLAPRPPDTAVLPDFGPEYAANPLAFTLPQQPAPPDQFAPVTCDPRLLVMPTTSAVPSCVAPAPVTQPDLQLRFQALPLSTPPCVVPKTSSSTKITRAVEAICPACGEGERVVPKVGVHAKTGAQRGHGSCVTYAVHVFVRQNRRCFIHASLHRFPNTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1P2</accession>
    <name>A0A4Q9Q1P2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="1" type="ORF">BD310DRAFT_922594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU60494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1P2"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
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        <source>
            <dbReference type="EMBL" id="TBU60494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="276" mass="30778" checksum="E6E16904270353CF" modified="2019-07-31" version="1">MSTPTYHLDVYKIPRESVDVEALAQQACRYLKIAAEDAEFLSYHATRRDEIVAELYRQPGIKHDTSPGQFVPLGGDPDVHLIPANVVIEQLTPPKSLEDRVKRLHFAAAAMSVFGQFKITYGLLDHPDLEMQYQRRMTQIMSVYYKTEFALLFPESMKRAAAKRMPATPPTLGHLPGPSTRPSTVPGRVSREDVDQFLNNSNTLVGKRFVHSPQGEGQDQDDSDYGTWHVASYTVRAADGGVEHEYQVVLEGLGGGALPMDGDEIRYLLQDSTFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1X2</accession>
    <name>A0A4Q9Q1X2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    </protein>
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    <organism evidence="1 2">
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        <lineage>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1X2"/>
    <dbReference type="Proteomes" id="UP000292082">
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="196" mass="22471" checksum="971EBE7436F60DE6" modified="2019-07-31" version="1">MPSRQWHAVHRVSDRVASLHILVQPSSNFVPIHSILGFDDDGGLVLCIRCTVRCKITPAPPSIQESGVGRRGTSWYQFPATATKMAHRIMPHVQRWSIRTQNRLNRQPYLEFYGVLPPKRTSIGCTGRCGKIRQHSKRINLPIPLWGTSNQFKFDPLNAMIRVFCRDVAVKKLREPRYMIVVFKSCAHEPNFNRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
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    <name>A0A4Q9Q261_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">B-related factor 1</fullName>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q261"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00043">
        <property type="entry name" value="CYCLIN_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
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    </dbReference>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="70230" checksum="199A445EC9AC470A" modified="2019-07-31" version="1">MSGRCEECGASTVWDTDVGSAICLQCGTLADPTQSVLASHLENTDVSGREYAPWANIPGGSTLRGRNGWALSGQGKESRDRKNTIAMHEFIRTIATRLSNPGLTTRAQGVFDQAMRLGEYRWGRKAKLTAGAALAIALRESHKSDSIRDIAYLLDEPPVAISRAFTKVIALLQLGLSTTDPAVHLPVLQTYLVSLLNGSGGAAAALPAQLVKVLSPLIPRFPSVIHTATALSSLLARTHTFAHLPTAPTACALFMLALEAELSSSLPNAGAFAPILGARLGAGKGVVMQRYKQIYDLVEEWIREVPWLDAHERKRAKGREGEGRSKVAKRVVVARGLKDVVRFQEEIWRKRVEHEGRPLVRLELDEKDAGASGSGDERDGSEAGGRSPRGTSVLGDDTPPRKKAKPRHPRTVVDASQFLLNPLSTAISSSPPVPVAGPPDLLTHLLTADASSLPHAFACAPTRLQLLASARGGTEERHITDEELFVEDELEGLMRSPEEAEAVRIAMGWDVESDDEEHDGGNVPVEKSSAKGKKRKRKSPAGEDVDAGNGSEPRGSKKINMEALARLLNPDGDFDVEAEDGVGGPEIYSRQVPVHEGDDEEGEEWDEDGEEEIGVGSYHEAGNVQHGAAGEEVVGEWRPPSPGGGHSEDWFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q286</accession>
    <name>A0A4Q9Q286_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_873676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q286"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q286"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="584" mass="59974" checksum="A277F1B37947E1A9" modified="2019-07-31" version="1">MAKAADKKADKKAKASTPAKKAAAPAPAKAAAKPISSKEILAKAKEQEKKKKSKGKKAESSSEESSESDSEDEKPKAKANGVAKAATKAKESSSESSDSDSESDAPATNGKAKLTPKAAAKPTAKGSSSSDESSESESASESAKKPAATPKAANAKKAAAPSSSSSEESSDDEKPKAAQVKATPKKTASSSSDESSESSSEDEAPAKAKTTPASAKKAAPAKKADSSSGESDSDGSDSSEEEEVPKAKKAAAPTKKDKSKKDESSSDEDSSVDSDEESEDVEMADATKAPAAKGKRKAEEDAPAPTKKVKIANGDAAPAEGGSETKTVFVGRLSWNVDNDWLAQEFAECGEVVSARVQMDRNTGRSRGFGYVTFATTEAVEAALKLSGKEIDGRPINVDKSEDKDKTAVRQSRAEKFGDTPNEPSAVLFVGNLSWDSTEDGLWEVFGSYGDVKSVRLPTNPETGKPKGFGYVEFTDIEAAKKAYEGVSGTEIDGRPVRLDYSQPRDNNGGGRGGGRGGGRGFGDRGGRGGGRGGRGGFGDRGGRGGRGGRGGFGDRGGRGGGRGGRGGARTGAIAEPQGKKMTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2F4</accession>
    <name>A0A4Q9Q2F4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_194725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2F4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="442"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="553" mass="60028" checksum="5948EC2E93F524D0" modified="2019-07-31" version="1">MPLTIPEPHPSGVVFMNVASHSEPGQASAPPEQSQLQKLPPSPFLQPLPISGSRCSSPGPSFPYADLATTSGASDTTCHSPTMTAYKPGVAENVVRLIPIFDHVIRPALRMDITFCEASQLFLLQNLDGRQVRMTMGQILRRYSPHIASIDVDATGLPNPSNPKTMACAVVLPFTPDAVASEEEQTCSHISGHSLPILPALEHLSVTTSRALSIRTLLKFLQYTPLLKTLTVTNGGHHQAILPDDVAKIKEPNLPYLEHVSINGLLTHTVEQLLNKLSPSINLRTTVQVHFQTPSFPAFKADSVLHTLLVPVRHAHLSYVALGDRDNDTYSHALFQPDQTQGAGGSKSYTDYLFSFSDDMGRVQLHWHWSEERGATPYLGHISLATRSLVRVRTVSLALYNVRPSAADLRHVLQSFSALAHVHLHVTQPEGRPGGAWHVHGDPSGDSSDSASYSGSCPGHVPLTSQHGEFSMRAAHVVRRIADVTTLFAFGLAQRLAKAQSQCCPCTPAHGGALDGEGARGCEQLALRLAPVWYRPLWALMVRKPVSGSPRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2I4</accession>
    <name>A0A4Q9Q2I4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="14">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_921024</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="14">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="14"/>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2I4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q2I4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="16">
        <location>
            <begin position="318"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU61240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="409" mass="46808" checksum="D6EA34D27ED6A359" modified="2019-07-31" version="1">MANMADVCNILGRLRWFNLAILTITPAVGLYGIYTTRLRWETLLWATACYVLSMLGITAGYHRLWSHRSYNASRPLQYLLCLLGASAVQGSIYWWARGHRSHHRYTDTPLDPYNAKRGLFYTHVGWMLIKPSVKPGPSDISDLKNNEVVQWQHRWYFAIIPIVGYALPTIVAGLGWGDWWGGWYYASMWRITFAHHSTFCINSIAHYLGESPFDDKKTARDHFLSALLTMGEGYHNFHHQFPMDYRNAIRWYQFDPTKWFIATCGALGLASNLRVFPENEISKGELAMQLKKLKKVQEEIRWPIQVDDLPIVSWEKFKKESEERVLVIVSGFIHDVSEFLDEHPGGRGLLLGQRGKDATAAFFGGVYEHGNAAHNLLSMMRVGVLLGGVEHVKAIAPGERLRIVERLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q360</accession>
    <name>A0A4Q9Q360_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_946403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q360"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="137"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="460"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU61585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="601" mass="66414" checksum="92E0AD08D29313E3" modified="2019-07-31" version="1">MDVFDDVKLKSEAHVFQQPIAKVSKSSVCHRRTVFGRRSKLLVVVASVVTLVWYHYDFLHDTELPNPVPRSPQNFGADDFDWYALSPSRDLNWTSCYSGEKCARLLLPLDYDTPDSPATAIALRMIPATDLENYRGTIFLNPGGPGGSGTDFVRRVGQNISRVVGPSFDILGFDPRGTGRSTPSRDIWDIQEGHQLLNASDSSLGLFHSRAKLLAQRCEDRLGGEWGIGRFVTTANVVSDMLQINKQLGQDKLQYWGFSYGSVLGQYFAAMHPDKVKRLIVDGVYEAEDYRRGRWGTNIVDAEHVADAFFTFCHQAGAEKCSLHDSSPERIRERFLRVLDEVEKSPVGVPGAEPPAIVTRKALITQLFFGSYKPLVSYPIIANTIRALETGDQNILTALAPQLVNLAECQCDAVSDLNNLADNEATYSIACSDSDGTQWDEDAFREHYATLEGQSPLGAPLWAYLHMQCLEWKIRPKTRWTGSLGAQSTSHPILVLSARYDPVTPLADARLVQTRFGGAGLLVQESYGHCSLSSPSLCTARHVREYFINGTLPEEGAVCGVDELPFIGSVQGDVQTLSSEDAELLDALRDAATAMPVYNRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q445</accession>
    <name>A0A4Q9Q445_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">malate synthase</fullName>
            <ecNumber evidence="2">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_176872</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the malate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="2"/>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q445"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q445"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01344">
        <property type="entry name" value="malate_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="8">
        <location>
            <begin position="157"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="10">
        <location>
            <begin position="408"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="539" mass="60448" checksum="9996BAD9210FC183" modified="2019-07-31" version="1">MVAGVQIHSSQAKDAQAQILTEDALKFIAALHRTFESTRQSLLVAREAAQQRLDAGQPLDFPSETAHIRADPSWLCAPPGPGLEDRRVEITGPTDRKMVINALNSGAKTFMADFEDANSPTFANMLNGQVNLRDAIRRQIDFESGGKSYKLSEKPAVLIVRPRGWHLDEPRVTVDNAPVSGSLFDFALYFFHNAHELVKRGLGPYFYLPKMEHYLEARLWNDVFNFSQSYIRLPHGTIRATVLIETLPAAFQMEEILFELRTHSAGLNCGRWDYIFSFIKRRRADRSAVLPDRKDVTMEVGFMDAYVRLLIQTCHRRRVAAMGGMSAQIPIKNDPKANEVAMSKVRADKLREVTNGHDGTWIAHPLINEIAMEIFNKHMLGPNQYHVRREDVKVAGADLLNTKVPGQVTTEGIRSNVATSLAYSAAWLGGNGCIPLNWLMEDAATAEITRVQLWQYVKYGIRTSDSGQVITPAWIDSLVDEIAPTLKTALVTEENLDIVAKYLKAQVRKEWPSEFLTSDLMGYLAVRDGCPAAWQRSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q493</accession>
    <name>A0A4Q9Q493_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_811559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q493"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="650"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="650"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="780" mass="84479" checksum="37E03D049E939BDC" modified="2019-07-31" version="1">MAASGSRSWPSLSPPSESSHEPPSSLSTEPRISISSTIYPSSSNNHSFDIPSYPSSPPHGRSSSMSPDRESFIDLASPTLSPRALDSQYIGIPSTTQRSLTDQPSSTSRRSGEISHVKSPVRASSTPSSQSGSTKPRLAPIIPPSTGYDKPPIPTAPKPDFSHRSRSSHRSSPVHTKKSSPMSAYPADHVDLADPVFSSSNALTPKERAERIRTTRKLAQVFGQPPGVSPVALEPGQEVEVPNGCLPVPVPLALNLNAKRRHHRPVNSLSEDVANTTPVHDAFGAIVWPPPDGTRYVSLAAHRRHSAPLSPDEFSFVTRLSSDTDRSTTSAGSSVIHIGSAQHDHASERASTASSRQSLARPAPGSPTSFIDLSDEEGAVAETPKVGRGRGQPFSPSTASLAESLTSDELAEEERRRKREKLAKLHRFLGSRVPPDLVLGPLDGTPLPPPAPSPLASFDATEDADVRKVKMRRRRSSSAAEFSRTWSDDIDRLKQGLNEREKAINVRRAIKMEKMFGVAPPQTLYHTRAPTVSTPNIVRDLHRQPSPKPAPKTPASPPFRFATSNAPKTKKSKRPGTGDSASSARPLIAHDGLLEAGSSSVYIHYRHSLNSLSDIIDRDDKESLAELHDYLTGNGELYSTGEQYDYQFDAAGSSNANNNVPSPAPATPMFGDDAPVASPSKAERRRSLPSRVSVASFSSEISALIAPTPTEASFQQRRRRAAKLTHFFGVDYRDLMNEVLESIEKGLEEERGKGTLRPDEVKDLQQKLVTLKTRRISLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q506</accession>
    <name>A0A4Q9Q506_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calnexin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_1036762</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the U5 snRNP complex required for pre-mRNA splicing. Binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the calreticulin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q506"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.250.10:FF:000001">
        <property type="entry name" value="Calnexin homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000011">
        <property type="entry name" value="Probable calnexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.250.10">
        <property type="entry name" value="Calreticulin/calnexin, P domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001580">
        <property type="entry name" value="Calret/calnex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018124">
        <property type="entry name" value="Calret/calnex_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009033">
        <property type="entry name" value="Calreticulin/calnexin_P_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00262">
        <property type="entry name" value="Calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00626">
        <property type="entry name" value="CALRETICULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63887">
        <property type="entry name" value="P-domain of calnexin/calreticulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00803">
        <property type="entry name" value="CALRETICULIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1418"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="18">
        <location>
            <begin position="135"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1161"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1444"/>
            <end position="1486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1179"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1202"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1222"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1453"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1476"/>
            <end position="1486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00055641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU62151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1486" mass="166906" checksum="02838B0C0C6CF687" modified="2019-07-31" version="1">MASFEDYDEFGNYIGADLESDEEEEEQNQFVPQPQVQPLEGFEEEPAANDEMALMEVDEPVHNAVVLHEDKQYYPSASQVYGEEVETLVQEEDAQPLTEPIVAPVKVRKWTVEEKDMPETRFDKGFLLNMMALPEFVRNVAVVGHLHHGKTALMDMLVFETHKLTWDSDHPTRYTDTHILSRDRAISIKSCPMSLILQNSYGKSHLVHLIDTPGHVNFVDEVASAIRLVDGILLVVDVVEGVMCNTEAIIRHALQEGVKITLVVNKIDRLILELRIKPADAYYKIKHTIEEVNTFISGINPDPDLRLSPENGNVAFASTDMHWCFTLRSFAQMYADTYGSVDVNAFADRLWGDIYYNRENRKFTRKPADPETNRSFVHFILEPLYKLYSQVLSEETEPLKETLASLGIQLKPIMYKMDVRPLLKVILDQFFGPSVGLVDVISEHIPSPLEATRTKVERTYLGPMSSELAQTMQECNPEGPVMVQIAKLYHTTDAQTFRAFGRVISGTVRKGMDVKVLGEGYSPEDEEDMAKAVVEDIWISEARYFIPAEEAPAGNLVLLGGVDASIFKTATIAGVDIEDDLHIFRPVKHMTQSVLKIAIEPIAPSELPKMLSGLRSINKSYPLVTTKVEESGEHVVIGTGELYLDCVMHDLRRLFSEIEIKVSDPVTKFAETVLETSALKCYADTPNKKNRLTMIAEPLERGIAEDIETGRVNMRMTAKERGKFFEEKYQWDLLASRSIWAFGPDDSGPNILLDDTLPSQVDKKLLGTVKEHIKQGFQWGTREGPLCDEPMRNVKFRILDASLAQEPIYRGGGQIVPTARRVCYSSFLMATPRLMEPIYYVEVQAPADCISAVYTVLARRRGHVTQDIPKAGSPLYTVKALIPVIDANGFETDLRTATQGQAFCLQVFDHWSIVPGDPTDTSIKLRPLEPASGQALARDLVLKTRRRKGLGDQISVSKYLDDEFIPTTLKAPFLEQFTDDWSERWTPSEATKKTPVGTETFSYVGKWEVEEPTEPAILGDKGLVAKTKAAHHAISAPFPKPIEFADKPLVVQYEVKYQKGGNCGGGYLKLLENGFQTAGKEFDDKTPWTIMFGPDLTCPGTKIHFIFRHKNPITGEFEEKHLKTPPKPTFGKSTNLYTLHVFPNNTYDVLFNGESQNLGSLLEDFNPPVNPEKEIDDPDDKKPEDWVDTKRIPDPDAKKPEDWDEDAPYEIPDEDAVKPEGWLDDEPEFVPDPDAEKPEEWDDEEDGDWIAPTVRNPKCDEAPGCGEWKRPFKANPAYKGKWYAPMIDNPEYKGEWAPRKIANPDYFEDLTPVKSLIPIGGVGIELWSMTEDILFDNIYVGHSIEDAHKFAEETYFVKKSVEEAVEKASSKLDEEDEETPVNFAADPVEFIRSKVFKFIDLAKIDPILAFKTHPETGAGLALSVVTLFGMLGVLFGFVGAQQKPITKSPKSAKKTDAPTPDDKKTETAPVAPAGGEKQETTVKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5Q7</accession>
    <name>A0A4Q9Q5Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_701889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5Q7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="112" mass="12371" checksum="D98CDC57493C3603" modified="2019-07-31" version="1">MSITMSPPPRKSALLCEACGPALLHKLKQHAEHTVRLPFCIPKFCGQGTLAMDCLTFSKFTPWSSPSPLQLMQVHARHTHGPVCIPVYPRVLLQVRACLRAVYINFAVFAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q640</accession>
    <name>A0A4Q9Q640_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L21e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_843360</name>
        <name evidence="4" type="ORF">BD311DRAFT_789537</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143440">
        <property type="protein sequence ID" value="TBU26810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q640"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q640"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU26810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="160" mass="18494" checksum="F729D1BF1EF2DA2D" modified="2019-07-31" version="1">MPHSFGYRARTRDMFKRGFKEHGPIKLSTYLTNYRIGDIVDIKANAAQQKGMPHKYYHGRTGIIYNVTPNAVGIIINKVVGNRYIEKRVNIRVEHIRHSKCRQEFLDRVKRNHDAHAAAKEKGERVNLKRQHVLPRGAYTISTKDNAPQTMTPVPYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6C0</accession>
    <name>A0A4Q9Q6C0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_698543</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6C0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="390" mass="42719" checksum="29A354AA2D8A7892" modified="2019-07-31" version="1">MAPIRGETDSKLAEPTYTEEFVQNEDGDFIVRFKCRTCGTTVSRKADVDRHINDKHRPPKYFCDVPGCKRVIVGFTQESNLNNHKSSVHLNLALYQCPHHWVDPHNGRIFPCRSKYKDRSSLSKHRKDKHGFKTGDDDAKVARPTPFGKRFPDSKGVSRAFTSLSIAGRSSAPYIVPPPSARRSSRMKVSKTVVIKQEQENDTTALEPGAVGWPSDPQPVKVAGWDMGSSSQQLREEARIDDYLQDPGFIALYEALCAQFALRASEALQIPTQVGAAADHYWTVDSQSPALGCHVAGAAFNGLTAPTGPTLPEPSGTTAFEQTNMLNAGSGPFPVHNGHTPTTWLWDESVFANSSASGELPSFLEDAFSTGPSQWMSTSTLGMPENHVCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6C3</accession>
    <name>A0A4Q9Q6C3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_656171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6C3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="173" mass="18397" checksum="46573189C86203FE" modified="2019-07-31" version="1">MRPINATPPDTDRPMMVDLLIPDDFAPDVSAPAVALPVELLPVEDPEGVEVTTTVITAPLEPVTTVLEREGEGGGEVSCVGVPVGLEVLLVLVLLVGEAVAVLVLVLVLVSVLVFVLVSVFVLVLVFVLVLVSVFVLVFVLVPVLVPVPVPVAGWVWGRQVHGLVVRQRRTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6P6</accession>
    <name>A0A4Q9Q6P6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1036538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6P6"/>
    <dbReference type="OMA" id="QRVPFRF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="200" mass="22432" checksum="E8E2C110507C3072" modified="2019-07-31" version="1">MTPAVRQRVPFRFSEDDDLDGHVLDEQEQEEVLDRLRKQNETSNAVYYTGLQFVVSLSLLIHAVFTFSSTKISPLAPLFPDSPSKPVPFTNALLLLQYIVHGNLILYCLPRKHHMRQMIPNASLPRSFSLPLPLSHPAAIVLPLIAPAYATFLGRGIVDVLWWSAAGILSLVVGLATKWMRDAEKDVEELDKLRYTARGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q720</accession>
    <name>A0A4Q9Q720_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q720"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018961">
        <property type="entry name" value="DnaJ_homolog_subfam-C_membr-28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394:SF1">
        <property type="entry name" value="DNAJ HOMOLOGUE SUBFAMILY C MEMBER 28 CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39394">
        <property type="entry name" value="YALI0E31793P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09350">
        <property type="entry name" value="DJC28_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="472" mass="52938" checksum="67FCF572E58B8568" modified="2019-07-31" version="1">MSSVSRLSSLRPRIPSSSLLCRRKLRRYGQNPSTPLAEPDRTASAKLFEDAAREEAAEEEALRKSSLVQRIESQHEIWTGDEPMEHAVLRMLVDKYKPLRGGPIRTADDKLKKAPPQVRTQDAPHEVARGDSSATISSALGKAPARTYVPGEPILPGIPGHQPWHTTFTVPSHATSSIRYGSIPPPKHALSPLPLDDKGRRKEMETRKRMQQGMRLSQARESTLDYRLGIKGSATDQFRRLNPVSLKGWANLVEDRIERARQAGHFKNIKGRGAPIARTTEDKNPFIGREEFLMNRIVQRQGAAPPWVEVQGELETAVRTFREVIKQSWTRRALRTLTHTHPAELLPKLTLADVAAMRDEGWEEKERGYHETALEEVNALVRKYNGLAPYAVRRAYYMRSAELERVYQEAGEDILRGLEERARQALNGRTNRRPGFGGDEEEVGGGGAGGPGGGPVRLRDMFRDVMNAIRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7F3</accession>
    <name>A0A4Q9Q7F3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_657583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7F3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16613" checksum="332F83A2A2D8BA7C" modified="2019-07-31" version="1">MSLIAERDRAQTLTERDMTVRIPKHESEPKPQCDKLLDGTPFPRITRAIASLVILKSLAPKPKSPQRTAASLAYGAYLILRPSPDPSLRMRSPTTTLVVESKARRVGSCWQTSPISTLHCQRLPRSPPALQSHLPPDGQSFWAAQPTPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7H6</accession>
    <name>A0A4Q9Q7H6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_973913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7H6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7H6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17378" checksum="962690805523236D" modified="2019-07-31" version="1">MSIQTHGIPVSTFDSTSFSSRTLSTPSPTIRTLMANLPTLASRSTSSASFCSLAICTPSLASADCLRFGICGHNFEANSILYYRFKLGLPLSLHQHDAAIADRWSQLAAGLQSAAIHLLWQPDVGLVKDNETTTLAPQDGNTWAVKSGLVTDALQIVLELED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7T2</accession>
    <name>A0A4Q9Q7T2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_582551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7T2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="377" mass="40942" checksum="97521126BD3D071A" modified="2019-07-31" version="1">MQHNHSRTATSRSGATATPGPSRAASGARTATATTCMQASDVLRLPLAHLPAHISPTLRIDWENRKLAVEFDFSGQQSDAGTVQCVQSLCGISDGAAHSLLASANRSQACCAVEGCLRPRPCKIHAARPARESAPSPQPAGRVAAPRIAPPIPRRKAARIVDANGPSGGATLDDTNTLRASNGDDASPAKTRTAAATFEPVMKAEPTDKIPGRRLHPQRRQFKIRNENRHTRWYRTTHAKPIDGPPGHLLKPPHGALYVHQYKVPHVGWQIWMFVKYDAETTARDGESRRASVQDGGVEASVNGSRDSDGVQGRERERERGHGGEWVRVYPGQPHPELEGYVLHMLDGGEPRWVKALSARQYASTRSKRVQVVDAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8T5</accession>
    <name>A0A4Q9Q8T5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_915137</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8T5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8T5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="446" mass="49038" checksum="2CD214F9CC45BABC" modified="2019-07-31" version="1">MNPNNSNSNFAQIPLPTFMNMMGGILSQSPHAPQTPMPQGVLQMQPGSAPTFEFIWQGWQQAGQQWLSMTHPGSQSSQQAQMSHIQGNTAGHTPHQSLAISDLAAFVTAMQPLLQNANPAPVGSVADDERILISALKEGKAEGLTPRQALDKLHNVNNHTESAWKNYFLDHLDRLYAKAYPSAGGHMEVRRQLPSSVTGAPSLEHLRRQHKVGLASANSRLEKPSTAASSSSQRQRVHEDHIEPLHRKAFRKACAALDPAQRKRGSRPIPLYEHGSDSDYSSSVETESSGAAVKRQKGILPPQRITEEDLRAMARFRVERPPPADISATGKGYWEKFARQAKKKRTPAGWARASISYEEVIEQYIAEHMAEIQGDGSARPQASGEQEQADVPSGELPKSGFSAACDGVSRLSTFPLKPRKRPVDEQDLESNREEKRFKSALDEASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA87</accession>
    <name>A0A4Q9QA87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_955143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA87"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6566" checksum="3E7FD21284127C31" modified="2019-07-31" version="1">MLTPFLGFRSLSSASGESSRRSRNRSSPRHNTVEALDLYELPPKTVAIDTLAAQYAATRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA98</accession>
    <name>A0A4Q9QA98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_972903</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA98"/>
    <dbReference type="STRING" id="114155.A0A4Q9QA98"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF70">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="8">
        <location>
            <begin position="172"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="604"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="663"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1058" mass="117434" checksum="47F28E16AB74DFB4" modified="2019-07-31" version="1">MQRQYTDIFPTLSSGLETSSEDVRKNAAALPGLPPSFFIPRLDDKPQNPIMDTLRLLRNKSQTEPFPAPQTSKLPPELESLSEDLLRFAQARQSNLEDIWQSAASRKHNKMNQALSWDALRPTFSPHANASPFLSEQTTSTFASARYHLRPPIQDPDVHLVYVQIPDLFQSLLLTVSGTSSHLHIWDPVRHRFFLRGLGEKKRGQVVIVGKDDIVSASLLQRFLTIGNLMRRLEILTDDRAPSHHRPSGQPTPILHAFRHALSSILAYLRENADAIPIDLQANPGADARLTALWTKYEDMSSILQALAALCGREEHVDPADYIPLPTTSSALLSAIYNHLTDHMERSSPRLVTAVLAFMLTNTSRGYMQDLCASVGYSTPSSTVQPPITKARVAYDDGLPSAFPKDENDYYGTGRREEGDFDFDVDGFPEFVRPELAEVFTRSRKSLVLLRAADPEHPLLTSKHLHPEIEWLWTEEQLENMEDGLAFSAGSVRTPARAIERDVGSTDSGPSSEDVLHSFKVFDLLRGESDPTPGNYPTTNLLSNAHFTTFLRAFLAAFPSYLPPSTPTLSHLAARVLSPLVSHAQALSGALVARFLSPATHLHLHTHLVLLRGYILLTEHAFKSRLQDALFSDAEDISAAVVGSRMHAVGAVRERARERSRTKSGQTSGSRSRSRVASGVIAGEEKPKKGERVVGLSPALTIGDKWPPLGSDLNFLLRTVVVDALEEGRAFAAADGEEGVHAEDEKVRAHRRIVEEAEWRLGFAIRDLPMGTGREKWLNPLAVEALDFLYMHYQPPFPLDVLITPAILSKYHRMFAFNLRLMRVENVVRTLFRLTRHPSAPLFATLSPSNKRLLHFRFVVHAFVMALSSYVYDVAIGSNMDSLLSRLSAAGGAEAGLDKSASSTDGGRVKTEPEAFADVFSLGEYHSRVLDDVLSSCLLRSGQRAVGDILRQCMELVLELGVLAGELKDGHLEEYEAAPLLEDLWDRFRAKMTTFVKVLKALVEKEADSAGLVLSDIPLHMMQGARRVSRTTANLHQLLLRLNMSDWWTRKEGAKAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBT9</accession>
    <name>A0A4Q9QBT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WD40-repeat-containing domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_1034767</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat EDC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBT9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045152">
        <property type="entry name" value="EDC4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15598:SF5">
        <property type="entry name" value="ENHANCER OF MRNA-DECAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="21932" checksum="52BF38DEE711A1ED" modified="2019-07-31" version="1">MVPCRQEHQSHAIVFDVSQPLDKIQAPQDAVKSTAIALVKVDSTFLPGTTIGATQWVAYAMTKGRVRVISCSSGDRTLLTLPSPFPPSTAVSDMSVHGNRLASVTSDGGLVVWELPDVITDDVPGRIMLCMYPQSDGEPLHAVKWHPQQPDLVAVASDTNMYLLNIADAVHVFGGDPIPQSELHRLSSPALMLDGAEAAKMMHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC49</accession>
    <name>A0A4Q9QC49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="60" mass="6869" checksum="A8109946609B0234" modified="2019-07-31" version="1">MERHYPGEPRSDDIAPSRPEQEHCTRPQKGNTDRERLIPIPLEVTPPSASRSCPEHPRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCH1</accession>
    <name>A0A4Q9QCH1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_866079</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TIM21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCH1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCH1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="391" mass="43118" checksum="4ADDEDEC137A247A" modified="2019-07-31" version="1">MNISRTRSILTHARRLCKSTSFPSASANAPLRIVVLSGWTQAYATHANVNTATNSAGGSKPSAASLLSSALDQKQRAARREDSAGPFTLGITPPRPDEVKPEKKWSELSAAGKVVRTTARTTNLVVILAGAGLTIVLMYALTSELFSRNSPTVLYNKSCELIKASPQVHQYLHEPLVFHNHPPTVSRPRHRNHYVSSQIFVDSTGREHMLLNFYVQGRPPGSASYAGEEQDGFFARISHKAQLAAMKLGEMSLEDVKEEAVRRGTRLAELTKGMFRFLTGEEDARPAAPPIPVQEKTVEEEQKGWLSSVTGIFSGIKGTTKSGRSSGDAYNGPAFTEGEVHADLVMNDQGYYEFRYLLIDMPNSNTRNPSRVFVHRSDGVRETEPIVRWHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCH7</accession>
    <name>A0A4Q9QCH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_9937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCH7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCH7"/>
    <dbReference type="OMA" id="QQKDHIF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="211"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="37684" checksum="2172175A05184F00" modified="2019-07-31" version="1">MKKKVLLMGASGSGKTSMRSLIFSNNPASLTSRLGATIDVEQNHVRFLGDLILNLWDCGGQDAFMDSYLNIQQSTIFQHVGVMIYVFEVETRNMEKDLDYYKACLAALQKYSPNAAVFLLVHKMDLARGPKADTLARKSKELKEASGDVEVTVFGTSIYDESLYNAWSRIVHILIPNASVLSRHLAKLASACSATEVVLFERTTFLVIATSTPPPPPQVASTNPPGLSSPKTNGQLSATSHSDHEAEYDPDPHKMAPTRYERTSELIKAFKYSCARVREEFHALEMELPEFTAVLDELTRNTYVLIVVHDPTIETAALRMNIRLARPKFEELQGNSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDM9</accession>
    <name>A0A4Q9QDM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="3">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_912178</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="3"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDM9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDM9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767:SF2">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE TRUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="TRNA-PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase II N-terminal" evidence="6">
        <location>
            <begin position="104"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="372" mass="41315" checksum="E54AFFD4C34788D0" modified="2019-07-31" version="1">MLLTARLSGLPPYPCLGFRFLSQIYTRPDFLAPTGYHSSKMPKETKSSPLSALFGVVKPSGPTSMSLVNDIKKLVANSPLFVEESKLKAKASKTTRKNKHGRDAVKIGQGGTLDPLADGVLVVGVGKGTKKLSDFLDCVKEYRTTCLLGCETDTYDSEGKQVRVAPWRHVTREQVEKALEQFRGEIDQVPPIFSALKMDGKPLYDYARNGIPLPRPIEKRKVTVHELELIEWKGDDHSFRWPEKKFTKEEQEAMEKALKSVDDTVSVKDEPEADAPSEGVPTAFVLRMKVSGGTYVRSIVHDLAHALGSAGHVVTLTRARQGRFALEPSEEGDRACVPWDAFEKALKDEGEADAHGRKEWEREVLDKLEVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDT9</accession>
    <name>A0A4Q9QDT9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COX assembly mitochondrial protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_913646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the CMC family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDT9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013892">
        <property type="entry name" value="Cyt_c_biogenesis_Cmc1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22977:SF5">
        <property type="entry name" value="COX ASSEMBLY MITOCHONDRIAL PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08583">
        <property type="entry name" value="Cmc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="10095" checksum="AE52B3C7ACA338F2" modified="2019-07-31" version="1">MNTLSRREEETLLKQTKASALKECDSVVKEFAQCAEGRTFSVAWECRQKYKAVQDCMLQYTGPEAMAIVRAEYLRLREEQKRAASTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEQ6</accession>
    <name>A0A4Q9QEQ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_953837</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEQ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEQ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000334">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="264" mass="29290" checksum="01A5A2C5F74BD228" modified="2019-07-31" version="1">MTWIKGALIGAGSFGKVYLGMDAATGLLMAVKQVELPTGSAPNEERKKSMLSALEREIELLRDLHHENIVQYHSSCIDDDHLNIFLEYVPGGSVTSLLRNYGAFEEPLVRNMVRQILLGLSYLHERDIIHRDIKGANVLVDNKGIIKISDFSLSKKLEDSLLPGHRAHRASLQGSVFWMAPEVADIWSVGCLVVEMLTGEHPWPHLSQMEAVSQVGSAKAKPPIPPDLSAEAINFLELTFELDHELRPSAADLLKHPWIANTPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K494</accession>
    <name>A0A4V2K494_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_91310</name>
        <name evidence="10" type="ORF">BD311DRAFT_722115</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143420">
        <property type="protein sequence ID" value="TBU28600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K494"/>
    <dbReference type="STRING" id="114155.A0A4V2K494"/>
    <dbReference type="OMA" id="EGFKIKP"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="8">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="9">
        <location>
            <begin position="391"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU28600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU62312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="513" mass="56912" checksum="81E327BA558D6B72" modified="2019-07-31" version="1">MPASPRLSDHELAAINAAAVTREYNVKPHLDYRTVSAVNGPLVVLDNVKFPSYNEIVQLTLPDGTKRGGQVLEVQGKKAIVQVFEGTSGVDVRATHVEFTGSSMKLPVAEDMLGRIFNGSGQPIDNGPKVFAEDYLDINGSPINPYSRIYPEEMIQTGISTIDVMNSIARGQKIPIFSAAGLPHNEIAAQIVRQAGLVKGPTKDVHDGHEDNFSVVFAAMGVNMETARFFRQDFQENGSLDRVTLFFNLANDPTIERIITPRLALTTAEYYAYQLEKHVLVILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRVEGRNGSITQIPILTMPNDDITHPIPDLTGYITEGQIYVDRQLHNRQIYPPINVLPSLSRLMKSAIGEKLTRKDHGDVSNQLYAKYAIGRDAAAMKAVVGEEALSPEDKLALEFLDKFEKQFVGQGAYESRSIFDSLDLAWSLLRIFPKEQLNRISPKIISEFYARKSRKATEDVKAPAQDKLVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4B7</accession>
    <name>A0A4V2K4B7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_812357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4B7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9757" checksum="0B5CADF6D5BE7C7B" modified="2019-07-31" version="1">MADSSAGIISVIESIINGNYCNDALLAFVTYEYTITLSLEVDLFWRRQLTGAGILFLLNRYLTLALRASIIVEGYITSSTRYGPISNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4B8</accession>
    <name>A0A4V2K4B8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_815288</name>
        <name evidence="2" type="ORF">BD311DRAFT_669206</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143458">
        <property type="protein sequence ID" value="TBU25624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4B8"/>
    <dbReference type="OMA" id="TESWIHD"/>
    <dbReference type="OrthoDB" id="2674421at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="45893" checksum="0B5029A8041AC1F3" modified="2019-07-31" version="1">MQPLEKATVDDELVDSGTPKLVPTVPMSTQRYNAAVKRVIPGNMSIRPGLFSYAKELEPPYLPEGWASYIQPEGQVYFAYESQPRMVTEARMHSETVREQVLRFAVIICKTLESKDITLPDSAELYLMPSEDGDTCRYYFVDHASHALFWLDEVDIYQLDLPEVISESHLGMVLQEQYWTHIEQFPSHRFESLHLAIDELISIFIHGEGDQLTSTGSTFAYTAKQSKNYLRILQNAKEHLRYAPSICIVARLWGVISRVRWQTFFAQERARLDRNQRVLDIPDSNRGRLFAVASRMLYNIPNARAIELEKLYVDNLVYIHTWTDFVQKSQNEWKEHLPWIFGVAIINLLLLFAPGTSGLLSALSLLCCAVAAGASLMLLARFDGINVRDPVDAVRILHSALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4S3</accession>
    <name>A0A4V2K4S3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_927995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4S3"/>
    <dbReference type="STRING" id="114155.A0A4V2K4S3"/>
    <dbReference type="OMA" id="TQEMKPR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343:SF10">
        <property type="entry name" value="RNA-BINDING REGION RNP-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32343">
        <property type="entry name" value="SERINE/ARGININE-RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14605">
        <property type="entry name" value="Nup35_RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="277" mass="29368" checksum="CD92FEA984466D14" modified="2019-07-31" version="1">MSANTIHVSGISQTTTESHLRDFFTFCGKINGIEYDQEKHSAKIHFEKPSAAKTALMLNGGTLDGAHLTIISDVQDAAAAAKEAETHHTGEHIDQADKPRAGIAAEYLAKGYTLSDQILQRAIELDQQHGISNRFLSYIQSLDTTLGSKVLGPEKTLSGKAHETIQTAAQQAKAVDEQRGISRTATDYYAKALSSPFGQKVKAFYTSTSKQVLDIHEEARRIHESHKASTHGATPSSTGVGTTSPPVDPSVQSVSTAGADASTTGGAPKTAEAPTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5I3</accession>
    <name>A0A4V2K5I3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1038976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5I3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="384" mass="44296" checksum="053EBF591063DFAE" modified="2019-07-31" version="1">MWEVERADPVTARRAANDLKTAKQHLRQGQNEQAVECFVKALDDYDNVDLVAEQARKFPDSHLAMRLLELTATKAREYLKRDLGQDCFEETFYAYGGFWGILDTRPYMRTLHAIAHVAFDMGDLDKAIATTVETLRLCQGDNMGQRSFLPPLLLRAKRYEDALSFCQVWLDPQYDGKQRPLGGCAFAAPDPEPLSQAFVDWHTESWRPTDLLLNAALASYHLYGDCEQARQYLSLGAKGNTRIMCEIWVRSRQPTKPYSRPRTANSREESHDYLWLMQDLWMEHDVWAWATRHPDVKEAALKRCGYAECSNREEAVFTFKCCGGCKEEWYCSPECQKADWRKHKLECFGYRQKLLASSPRDKDFGSESSVSDDEDPDSLVRFAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7U2</accession>
    <name>A0A4V2K7U2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_959559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7U2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="95"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="207" mass="23170" checksum="18F6B481D65DC1C5" modified="2019-07-31" version="1">MEGDRNMPQSQELWEKRKLPFDAKETQEAWENAAESLQTYSEEMVQRWNAELDNMLLHAALFSAILTAFDVQSYSLLQTAPPDPVLSALQRISTQLAVWLNTLWFSSLILSTTASSVAIMVKQWLREFQRGVSGTSRASARDRQHRLNNLLKWQVPAIVAALPFLLQLSLNLFFDGLLTVATVATVLIGIHTIFAVGTTILSVLVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K802</accession>
    <name>A0A4V2K802_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_496078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K802"/>
    <dbReference type="STRING" id="114155.A0A4V2K802"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080090">
        <property type="term" value="P:regulation of primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000010">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase Pin1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="53"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18135" checksum="EAC6DC62D6315854" modified="2019-07-31" version="1">MSNWEVRISSSRGVPYYYNTETKESLWEAPAGLTQEQVAALPGAKQYLSGDRPAQVRASHLLVKHRGSRRPSSWKEQNITRSKEEAIEILKGYAHEIDGSAEKFAELATVHSDCSSHSNGGDLGFFRPGQMQKPFEDATYALKVGEISDIISTDSGVHLILRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K977</accession>
    <name>A0A4V2K977_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K977"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6348" checksum="D012F5E22AF93A7E" modified="2019-07-31" version="1" fragment="single">HSVKGQILAGENMRRMCGFPRHSLHIVPHVLQDGESVDYMHVASTFSPCSLVLDSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K999</accession>
    <name>A0A4V2K999_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thiamine pyrophosphokinase</fullName>
            <ecNumber evidence="7">2.7.6.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_667261</name>
        <name evidence="9" type="ORF">BD311DRAFT_654232</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>thiamine + ATP = thiamine diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11576"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18385"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiamine pyrophosphokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.2" evidence="7"/>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K999"/>
    <dbReference type="STRING" id="114155.A0A4V2K999"/>
    <dbReference type="OrthoDB" id="25149at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00597"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030975">
        <property type="term" value="F:thiamine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004788">
        <property type="term" value="F:thiamine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006772">
        <property type="term" value="P:thiamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07995">
        <property type="entry name" value="TPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.320:FF:000001">
        <property type="entry name" value="Thiamine pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10240">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.320">
        <property type="entry name" value="Thiamin pyrophosphokinase, thiamin-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006282">
        <property type="entry name" value="Thi_PPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016966">
        <property type="entry name" value="Thiamin_pyrophosphokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007373">
        <property type="entry name" value="Thiamin_PyroPKinase_B1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036371">
        <property type="entry name" value="TPK_B1-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007371">
        <property type="entry name" value="TPK_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036759">
        <property type="entry name" value="TPK_catalytic_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01378">
        <property type="entry name" value="thi_PPkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04265">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04263">
        <property type="entry name" value="TPK_catalytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF031057">
        <property type="entry name" value="Thiamin_pyrophosphokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00983">
        <property type="entry name" value="TPK_B1_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63999">
        <property type="entry name" value="Thiamin pyrophosphokinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63862">
        <property type="entry name" value="Thiamin pyrophosphokinase, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamin pyrophosphokinase thiamin-binding" evidence="8">
        <location>
            <begin position="183"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR031057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU32502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU63078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="261" mass="29354" checksum="7BFB07ADF27FA436" modified="2019-07-31" version="1">MASVAPSAVYSVTPWEISFLDPLRQSRNALIILNQPFSFPLLRRLWYSSAWHACADGGANRLHDLLKDHDGKDIRHLYTPDLIKGDLDSLRVDVQLYYASRGVRIVRDEDQYATDLMKCIASLVDDEKAERHVEQHTIVILGGLSGRLDQTVHTLSLLHKLRRSRQRVFVITDDSVAWLLDAGEHRIAVDHTAFGPTCGLLPLGVDSTVLTTTGLKWNLTDQISSFDGLISTSNHLLPEEPVVTVKTTKPLWWTMELRPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9T1</accession>
    <name>A0A4V2K9T1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_866723</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9T1"/>
    <dbReference type="STRING" id="114155.A0A4V2K9T1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU65078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="41069" checksum="7E44CBF541D5691F" modified="2019-07-31" version="1">MPEFDTEWPADSTEFCPHPSARDMFVCGTYKLEQYQDSSLDGPGTPDEEGAIDSHRGKPQVRRGKCLLFRVQENDQLTFLHETSLPAILDMKWCHRAPTVSPLLAIADSEGHVTLHELRNEESRLHQLQSIPCASSDRLCLSLDWSNRRIPTEGLGDLIVSLSSGSLSLLRPGDEGLVEADSWHAHDYEPWIAAWDYWNTNVVYSGGDDLKMKGWDVRQGGDQPTFTNKRFDAGVTTIQCHPYIEHLLAVGSYDNTVRLFDTRKPLVPLVQVDVGGGAWRVKWHPSETRKNDLLVACMHDGFKVVRFDTGKGNATTVSSTEIVQRFHKHTSLAYGVDWSFAEDGESAGTLVASCSFYDHTLHLWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWT5</accession>
    <name>A0A4V6MWT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosylmethionine transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_925883</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWT5"/>
    <dbReference type="STRING" id="114155.A0A4V6MWT5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000018">
        <property type="entry name" value="S-adenosylmethionine mitochondrial carrier protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="184"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="278" mass="29413" checksum="47F31F65A4D7FD12" modified="2019-07-31" version="1">MSTPSAPTFYQSLVAGGAAGTAVDLLFFPIDTVKTRLQSSQGFIRAGGFRGVYKGVGSVVVGSAPGAAVFFCTYDTLKKTLPLPSDYAPVAHMISASIGEVAACSIRVPTEVIKTRMQTSTYGATSSLEAARHVLSTEGVRGFYRGFGSTIMREIPFTSLQFPLYELLKLRLAKVAHRPLHSYEAAGCGGIAGGVAAALTTPLDVLKTRVMLDLRDPTKHAHPSLAARFRDIYVKEGVKALFAGIVPRTLWISAGGAVFLGVYEQVILTLTGGPPKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MA44</accession>
    <name>A0A4Q9MA44_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_958754</name>
        <name evidence="6" type="ORF">BD311DRAFT_730448</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143490">
        <property type="protein sequence ID" value="TBU24005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MA44"/>
    <dbReference type="STRING" id="114155.A0A4Q9MA44"/>
    <dbReference type="OMA" id="QYEGTML"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="87"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="399"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU24005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU58623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="668" mass="73775" checksum="E66578F3F743C696" modified="2019-07-31" version="1">MAPSASKQKRLAEKAAKQSAKVKGTDASTSTSTPTGSVNGGSSVNTPLTSMSAATSQEDLSAMAKLQIATDRSAAGVLVSDPKGRDIKIDSYTLSFHGRLLIEGAEVSLNYGQRYGLLGENGSGKSTFLQSIADRDIEIPEHIDIYLVRGEAEPSEVNAVDYIVQSAKDKVAKLEQRIEELSVADDIDEVQLDHLYEELEEMDPSTFEAKAGSILHGLGFSQQMMAKPTKDMSGGWRMRVALARALFVKPHLLLLDEPTNHLDLEAVVWLEAYLSMYNHILVITSHSQDFMDTVCTNIMDLTTKKKLVYYGGNYSTYVRTKQENEVNQMKAYNKQQEEIAHIKKFIASAGTYANLVKQAKSKQKIIDKMEAAGLVEKIEIPKPLRFNFEDVSKLPPPILAFNDVAFSYSGKPEDYLYKNLSFGIDMDSRIAIVGQNGTGKSTLLNLITGALQPTEGTISRHVGLKLAKYSQHSADQLPYEKSPIEHLQSLYHEKFPDKDMQAWRAQLGRFGLSGSHQTSAIKQLSDGLRNRVVFAQLAMEHPHILLLDEPTNHLDMASIDALARAIKEYEGGVVIVSHDFQPPAVAAAASAARMPVRRWTNFTSSASSYGLISQVAEELWEVKDRKIKNLTKEDITIVDYKNMLVKNSHAALEKAKLFSKTTSKTKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MAQ1</accession>
    <name>A0A4Q9MAQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Monocarboxylate permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_869190</name>
        <name evidence="5" type="ORF">BD311DRAFT_781099</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143483">
        <property type="protein sequence ID" value="TBU24265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MAQ1"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF177">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER MCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="382"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="256"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU24265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="454" mass="48729" checksum="62005179504D11DF" modified="2019-07-31" version="1">MNHVTVVDKRDLEKAEEQLTVVGRAVAEDPLPEPSAEPELEYVPDGGREAWTVVLGSSLALFASAGMINTYGTFQNYYETTLLPSSSSSIISLIGSLQIFFLYFLGTITGRIFDAYGTSVLIPAGTLISVFSLMMVSLAQKDQAYQVILSQGVLFGIGLAMLFNPAIAVLGHWFRRRRALAIGLTTGGSASGGVIFPVILEKLIPAVGFGWAVRIIAFIILGCLTVSCLTIRTRLPLSGRISLRTAVDLGGWKDPRYGLATIAGFLLFYSFFIPYFYIQIYGNFRGVRPGIANYLLAIMNAMTVPSRVLPGFIADRYGTLHVFVPAASICTILVLGLWLPSRNAASIIAFSALYGLFSGAFVSLLPTYIASITPREVYGARLGSVYMVVAVATLVGTPTGGALLKVTDESHFTSLIIFSGVLIGAGTVTLTMAGLVGSPRLRWISERSPFGKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MCT9</accession>
    <name>A0A4Q9MCT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Polyubiquitin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_933229</name>
        <name evidence="7" type="ORF">BD311DRAFT_701132</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143469">
        <property type="protein sequence ID" value="TBU24979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MCT9"/>
    <dbReference type="SMR" id="A0A4Q9MCT9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MCT9"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000016">
        <property type="entry name" value="Polyubiquitin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="4"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="4"/>
    </dbReference>
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        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="77"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="153"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="6">
        <location>
            <begin position="229"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU24979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU55630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="305" mass="34222" checksum="A1C7B4F656A28C3C" modified="2019-07-31" version="1">MQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVESSDTIDNVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MQ49</accession>
    <name>A0A4Q9MQ49_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_937429</name>
        <name evidence="2" type="ORF">BD311DRAFT_758484</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143422">
        <property type="protein sequence ID" value="TBU28351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145206">
        <property type="protein sequence ID" value="TBU53725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MQ49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU28351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11872" checksum="17A71A41C047D5BA" modified="2019-07-31" version="1">MDSVVRSRDSSQHMEVVAQRSSSPSGGSTTIMAAKPLPEGEGPLQTHHGRNPILALAWSPVDRLVIPLIHTMTHAAATGMRTLEVVWMRSKDAANLVFGDKALDVETWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MRF2</accession>
    <name>A0A4Q9MRF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Nnf1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_1037101</name>
        <name evidence="11" type="ORF">BD311DRAFT_755370</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143408">
        <property type="protein sequence ID" value="TBU30145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MRF2"/>
    <dbReference type="OMA" id="AHKWTYE"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="123"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU30145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23104" checksum="56AA967830AFA687" modified="2019-07-31" version="1">MASSASTQPGSKRWSYFHSALQLAIQRSAHKWTYEDFAECFSLWCDEQPENAATIFNLVSSRLESSITENCEELFKKYNVKDNLDNLHAVVTAARARKQAEYDGKDVWREDLQPRAAVRARTIPLLEQERDRLRAELAQLTDENSELQSQMQQNVRATEEADRDAARLLDVIDKVLAKWDQIPLDDIQSWTLQTAESAGSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB92</accession>
    <name>A0A4Q9NB92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_168667</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145221">
        <property type="protein sequence ID" value="TBU53194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="328" mass="36719" checksum="863F7F74113D148C" modified="2019-07-31" version="1">MAFEACRALRRDANAIPVEILDHIVTSLLSHDRRFCAIANFSLVSSRLRLIAFRRYFETLEVRSPRHWYKSCRIVGMFTWVRQMRVAASYVRSNMDALSSFVSLRSLEVDFSSDGLSTQKTRCWLLFKSLAADLTVLKLTSLPRIDTTLLSLVASRFPSLTTLELSSTERLDKECCWLCFEESSSCTIHSPIPDVFPSVEVLANAYGRALQPLENLVHLFLGVFLSDADVLSCHFDRCASVVISSPRTGFYSSPPFGPDRCVICTAEHGAAIHQRERLASGIIGKILPSLKTVGWSSHFSEHGSGADRRTKTTIFCARTPEVKVDSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEP3</accession>
    <name>A0A4Q9NEP3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">NADPH oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_916024</name>
        <name evidence="10" type="ORF">BD311DRAFT_683029</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEP3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NEP3"/>
    <dbReference type="OMA" id="FTFAKEH"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000091">
        <property type="entry name" value="NADPH oxidase (NoxA), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF39">
        <property type="entry name" value="FAD-BINDING FR-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="236"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU34806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="557" mass="63448" checksum="04A4E7E330962DA1" modified="2019-07-31" version="1">MGENFFQREFLQPRRLAFNVIFYGLHLFFFAYGWHSQETNKKLSALNALTWSVWTSRGAGLVLAFDGGLILVPMLRNVIRVVRPRLAWLFPADENIWFHRQVAYSMAFWAMVHTTAHYVNFFNVERTQVRPEIALDIHYKQAGGISGHFMLLIMVLMYTTAHHKIRHQCFEAFWYTHHLAFFFMIGLYAHATGCFVRDSPGPDYISSFPFYSTEHCLGYESWRFTIWPGIIYFGERVWREIRARRATRLSKVLVHPSGAMELRIIKPSFKYVAGQWLFIQVPDVSGWQWHPFTITSAPEDPYVSVHIRQVGDWTYALGERVGAGPQVVAAMTKAALKGDEKDDRAYGSRGDFVEIDSTGRALPAVRIDGPYGAPAEDVFNVEVAVLVGAGIGVTPFASILKHIWYRQKKGTLGSLKRVEFFWVCRDAPSFGWFQTLLQEVEAAQADPNFLRINIYLTQKISEDMLWNIAVNDAGAEYDPLTLLRTRTMFGRPDWKSIYARMSQAIQSGQYLPGTSAQLKTTVGTYFCGPGVLAKAIKEATVAAQCSSINFTFAKEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHE7</accession>
    <name>A0A4Q9NHE7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoplasmic reticulum junction formation protein lunapark</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_923566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in determining ER morphology.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lunapark family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHE7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHE7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098826">
        <property type="term" value="C:endoplasmic reticulum tubular network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071788">
        <property type="term" value="P:endoplasmic reticulum tubular network maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903373">
        <property type="term" value="P:positive regulation of endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040115">
        <property type="entry name" value="Lnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019273">
        <property type="entry name" value="Lunapark_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22166:SF12">
        <property type="entry name" value="ENDOPLASMIC RETICULUM JUNCTION FORMATION PROTEIN LUNAPARK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10058">
        <property type="entry name" value="Zn_ribbon_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Lunapark zinc ribbon" evidence="3">
        <location>
            <begin position="229"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="350" mass="39465" checksum="4C77419A1EE7AD4F" modified="2019-07-31" version="1">MGLFSRWFKPSQPEDYEQALALLAQDIQKRQTRLSEIRLRERRATLLVSVWALVAWVTYTSLWYMDFLPNITTHQRSSNFERTAKAIPVFVGPIVILFIRRIVQIWYTRIGDAEEKALVKLRKKQREKIEEVKQKTNYYSMRSLIERYESSPAPESPVGLRRRVPAVPQPQPPVPGPQLQQQQLAPQTPQRGGLQVNPQTPASGTLTPGLQQQLSPSPQRPLPPPRKQWFDKLADAILGDEDASTTGAASRYALICQKCFAHNGLVKESQWEDAQYVCPKCGYFNPSARTIREIKEGKKSRSPDGRSPFVQSAPASKNHFAPPIGTPIAAEDGRHAPTTTDEPTSMDVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHN9</accession>
    <name>A0A4Q9NHN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_795408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHN9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="9160" checksum="95D4F170D1F5E7A3" modified="2019-07-31" version="1" fragment="single">GQQKYHPQHLCKHLVQAIEFPSSKFFHQIYRRRTAPIYRHPELRDRTESSLGAGFLDADDGSITDGDDHVWLGDRAQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NI98</accession>
    <name>A0A4Q9NI98_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
            <ecNumber evidence="3">3.6.4.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_187464</name>
        <name evidence="14" type="ORF">BD311DRAFT_753321</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="3"/>
    <dbReference type="EMBL" id="ML143401">
        <property type="protein sequence ID" value="TBU31136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145231">
        <property type="protein sequence ID" value="TBU52934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NI98"/>
    <dbReference type="STRING" id="114155.A0A4Q9NI98"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000005">
        <property type="entry name" value="Heat shock protein ssb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="647"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU31136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU52934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="667" mass="71812" checksum="FF19C76CD02A63EB" modified="2019-07-31" version="1">MFAAARSVRVAASRSGNYAGLPRSMIARNMNSKVNGPVVGIDLGTTNSCVAVMEGKTAKVIENSEGARTTPSVVAFTKHGERLVGLPAKRQAVVNSANTVFAFKRLIGRQFNDAEVKQDAAHWPFKIVPKPDGRPAVEVTNGDKKQQFSAEELSAMVLTKMRDTAEQYLGKKVNHAVVTVPAYFNDAQRQATKDAGTVAGLDVLRVINEPTAAALAYGLDRADNSIIAVYDLGGGTFDISILEMQKGVFEVKSTNGDTHLGGEDFDIYLVEHILKEFKKESGLSLSEDPVAIQRIREAAEKAKIELSSTTQTEINLPFITADASGPKHINMKIIRSQFESLTSPLIQRTVDPCKKALADAGVKASEVNEVILVGGMSRMPRVVETVKSIFGREPSKGVNPDEAVAIGAAIQGGVLAGNVTDILLLDVTPLSLGIETLGGIMTKLITRNTTIPTKKTQTFSTAADGQTAIEVKIYQGERELVRDNKLLGNFNLVGIPPAPKGIPQIDITFDIDADGIVHVTAKDKATGKDQSMTIASSSGLSDKDIERMVSEAEEYAETDKARKQLIEEANKADSVCADTEKAINEFKDQIDATEKEKVTKLIAELRELAVKGQAGDASVDADKIREKVNETQQASLGLFQKVYEKRNAEGAASSEQPASENKEEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJ09</accession>
    <name>A0A4Q9NJ09_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_937785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145211">
        <property type="protein sequence ID" value="TBU53540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJ09"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="579" mass="63630" checksum="DA4F69AAA5B4A32F" modified="2019-07-31" version="1">MQQRRDGRDNHPRNGAIAVVGAGLAGLITAYTLIRDGFEDVQVLTRDAHVGGNWAQGKTYPGLYLNSVHGEYCVSALSMPPPASDCGRTSGDEVGAYLETFGSKFLKDKIQYGVEVVRIERPPSGTGWRVRVHHRKTGLTEVRHYRRVVLCTGGQSAPRFPPNMSPESAAASGFKGIVFHSADFGSKLSDLLASVPPAVSSAEPDSPTVLVVGGGKSAQDIAAYLANEGRKVTIVCPNFDAFLAASEPLPNWVRKSRLLSLFSPHIYLRTWLERFVHTTWLGKKLFDLFWTGLVSASFKAAGIPLGSPLRNTVSPFWHDRVNDEGVPRPNGFHALALSGKISVVSPAYATSFGTDGESVLLDNGVSIRASAIVLATGYHSSWSAMFDEEAQEELGLKPHLAYQSQPYRWDYLTLRDPPPLNPVAERWSSSIYRGIVPAKNIERRDFAVNGAIFSTHFGYMLEVGSHWISSYFLEDDMRLPATSEVALEETERQAAWLRHRYPQVAPTANSSHTSNIGFWGWPQVADDLLEDMGLKVMRSGGTWLTWPFRVVSVKEIAGLKEERDARRALKGTSKYAGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJ88</accession>
    <name>A0A4Q9NJ88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_328631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJ88"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJ88"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="816"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="900" mass="97243" checksum="69F53ED4B3F21CB8" modified="2019-07-31" version="1">MVKIMQPQGDAATELSTSYMRPRTRSQTKAARSRPTSKRKGSGDDNLKLPRPTKLPRTDSSEDVSDYCRDTPSDYACNSSSEVPRSMLVSFRVAPSPFQMYDGASRTSSVTDATYLDTQRFVASGPEPMFEYSWRVMFKKAYTPTEETGSPVITPQSTVCAVACLSGANSPSTSLSVPPPSRRTNKRADENVPPVSLTPLSQLVDISGRSTSRNAAKADPFPLHPLVNTQSGLPLAIKRHSPSLGFQHVVGSTWSEEYLTNSTARLSASRSWPLPVNPSTSLLSPHLPPTSVPALPRSALVSMSRGLPLRSDSALRTSNPPQVERPVQSSQGRTRGLPISFPLVRSQPGHSLGGPITVPYFPLHLPPPPSLTSYPTHQSGSPPNVPRVSGVHNRSVPHLHHATVDHLTPHTTGIPRAFSDLPYGSFPPTGFHPIPESLATSSPPSTEQSTASVSMPWCTLFDNLKQGKGDSEQGKKRRRTTAVVHESTEDLPCAQSSAIDVNNDEDEEEMVHPCPLCPRNFSLPNSLAIHLKWHWGASTLEWKRGIMKNGKGLEKALSEAEERRRHASTAQAGQQEIDNSAPPSPLSPSLPTCASPDDRTTRPPVIKEDESQDTSILDSTYPFAMPVFSQSSFNIFDLPFCASSDASMFEFDDSTGVLPPDMMGSFLFPELALLPGEGAPSTLNAADASTAPLCEFGGEMMNLPLEHEYGSAVDTPIAAEDVESGSSSLWSPDLFGCDEDVDEDRDAEGEEDLEDLFGAQEGFEAYVGTERLGNQGADYEIAPATTHEGADHVRSTLRISDQRIVASSQDVLTDNCTRRDRSTRASLEDGGRPVAVHAPRLTPLDLPPPQLGDHNDDSGSAEHINDEERELLAALAPLSDLIALPSPPSELDVLDQLSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJD2</accession>
    <name>A0A4Q9NJD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_560645</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJD2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF74">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="554" mass="60688" checksum="201D20786ACA2AF4" modified="2019-07-31" version="1">MMSSQPSPTSTLHDPVHIHPHLEEDLRQEYELRAEEYGGDDPREPPSKEQGAIPVPEQVATPDPNKVAWDGPDDPANPQNWSNRKKWAVTCLCVLMTVNVTFASSAPSAAGSFIAREFGVSTEVGYLVTSIFLCGYVVGPLLWGPGSELYGRRIIFRFCLAIYVILHLGQALAHNMQTLLVTRFLTGVFACAPLTIAGGVIVDIWDPVTRGTATAIFSAGVFVGPVLGPIAGGFLTMSTLGWRWVFWVMMIFAGACTILAYLFLPETYAPVLLQWKAQKLRKVDPVQNAKVYAEHERSDWSLRGIIHRTVYRPIQMLIREPILLLVTIYLSLVYGVLYAMFEAIPVIFITTRGFNIGESGLVFIGVGLGTSIGAYLTIPLSKHYPALMVKWRGFPPPEERLYGAMIGGPMLVIGAFWLGWTGQYSSIHWIVPALSTVPIGAAVSLVFNSFLAYLVDTYLQYAASAFSANTIIRSCVGAAFPLFTVQMFRGLGINWACTLIGLCALLLAPSPFLFYKYGTWVRAKSKFSPCLDLAIAKEIAAEEAAATEKGAQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRH6</accession>
    <name>A0A4Q9NRH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_936353</name>
        <name evidence="3" type="ORF">BD311DRAFT_760446</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143432">
        <property type="protein sequence ID" value="TBU27451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU54263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRH6"/>
    <dbReference type="OrthoDB" id="3269515at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="683"/>
        </location>
    </feature>
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        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
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        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="440"/>
        </location>
    </feature>
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        <location>
            <begin position="479"/>
            <end position="494"/>
        </location>
    </feature>
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        <location>
            <begin position="507"/>
            <end position="523"/>
        </location>
    </feature>
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        <location>
            <begin position="598"/>
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        </location>
    </feature>
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        <location>
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            <end position="669"/>
        </location>
    </feature>
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        <location>
            <begin position="671"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU27451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="759" mass="81430" checksum="59C83655D25945F5" modified="2019-07-31" version="1">MTTAPLTVVACRPCLGLGLRFSLCFFFIIAGHVWSHPTGQPFSPHTSGSVVKRQNTPTTTSSFDWWPYPSWGQSTSASPPTSTVPTLSLSSLAAAEAASLSVTATTTIFTTTTAATPVFSAATPATTSFSLVHITALPPASKESSITLNRARTTQSKSTGGEFDIVWLAPLFGILAAAFGAAVAWLTYRYLPLFGSRASRSGSRESALLPGPPYGPASRFRDAASGVTASLMDEGEDDQEFDAARSPKSARGNSKVRTWLGRSMLRRNKTLPVPSAEEREPEQPPETAARDHPEPGSAEHDTFLGNAESTAVDAPDGTPMQAGRATGMSTPSQSVNSSDPYGESSRAGDAVLYETTRNKSIKRVILDRFRFGSARKANYERGMTTDDDVEINGRARSATSLSSVQHRIGHRRTDTDGHVTPLAGGTPVPSRRPTVSRTRSQQVLSPPGFRILVEDPVSGALHNEDVDFIRAPSSASSHQRQDSDKYTRLPERRGPYPSTSITTTLERTTTDVSTSPSVYSSTSPVPPRLARPAINRYESSILLSSPPIVTSPALESQLLFGSTASLHALQLPALSALRVSKPPSARANSGVPATPPNAKHHRKLKTHRQPPLLPFPSSAESSPFRNRLKKSPQRMPQTYVPLPPHAKRADSNDSVDTVSESFTTASSGSPDKARAERYGRATPAERFRARHAALEKVEAILSRSWNERDGTGTETPRNLGAVLGADSAEELEKTPGREVDLGEALRGTGIEQRLGVFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSG1</accession>
    <name>A0A4Q9NSG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Emp24/gp25L/p24 family/GOLD-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_923369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSG1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NSG1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="42"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="224" mass="25014" checksum="4DA5FA0CAC1C6D95" modified="2019-07-31" version="1">MVSPAHTGLRALPFLFVALLVCLSHPASAIKFNLPASRYPPAKCIWNAAHPGALVIITANVGPGEGQRLDIEVVDSSEHKNVYLSKKNISGEKRFAITAHAEEDIGVCFRNYLEAGVSDSKGRSRVVDLDVDIGADAVDYNAIANQESLSGLETEMRKLEGVVKEILDEMEYLRGREERFQATNISTNKRVQNFAWFIFVSLFGLGVWQIFHLRAFFKRKYLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV29</accession>
    <name>A0A4Q9NV29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_960016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV29"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050608">
        <property type="entry name" value="NmrA-type/Isoflavone_red_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349:SF93">
        <property type="entry name" value="ISOFLAVONE REDUCTASE HOMOLOG P3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43349">
        <property type="entry name" value="PINORESINOL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="320" mass="35901" checksum="7E725447A9F8A018" modified="2019-07-31" version="1">MDSDNRPLVLVVGATGRTGGTIVQGLLASGNFRVATLVRKASLSSPTTEALRTAGVEVRVGDMKDSIEILSLALKGVDILISAVAGALVLDQKGLLSAAKTVGVQRGVRQVLDQKLVIHEFIQQLQLPFTFIDVGWWMQTYLPLPQRTIVPEHCRAFTETIVGKGEAKNLVTDYRRIGTYVARIIADPRTLNRSVIVWEDEVSQQTAQQLAEQYSGEADFIRSRRIYVGRDYFLTQAAEGRKKIAQDPSKATFADYVAVSFNEYKHSMYVLEENTLENAKRLGYLDVQELYPDLPRYTLEQFAREFYQLPEPGWEYKAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVA0</accession>
    <name>A0A4Q9NVA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_937431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145206">
        <property type="protein sequence ID" value="TBU53726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVA0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="504" mass="56742" checksum="BA71E2544930375F" modified="2019-07-31" version="1">MEVSQGAVYGALAALLAMYILRWRRSPLYRIPTLGGPSDPVLSYWSAFNYLINSRHILREGYEKFHGSAFKIALLDSWMVIVNGSKLVEEIKRRSGEELSAVEETEEFLQIQYILGCEPRDDPYHVDLISGKLTRTLSAILPELLDELRVSLPEYVPTHDDEWATVDATTTMQRVVARLSNRAFVGLPICRDKEYLRLATAVAMDFVKDGFILKMFPQFLRPVVAMLTGSTKRTIRRTLPYLRPVIRERRSQIAEHGLGPDMPGKPGDMLQWIIEQAVPREGDDESIVTRVLLVNFASIHTASMSITHALYHLAAAPEYAEPLREEVMSVTEAHGWTKAAMGRMWKLDSFLKESQRYNGIALTTIGRKAIKDVILSDGTVIPAGTRVASNTYGMHFDNAYYPDADKFDPFRFLNIRKVQGESTKHQLVNTSNDYAAFGVGRHACPGRFFAAIELKAMLAYIVLNYDLKMSGDGARPPNMYIGPTVLPSMNGKILFRRRRTTGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVB3</accession>
    <name>A0A4Q9NVB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_411087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVB3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="169" mass="19037" checksum="078D4E498DCD72D7" modified="2019-07-31" version="1">MVFALIPEVRHVQPGLVFSLHRTSRAATWKCKAHGPSYQVEAQDCNARGILPAESGRRDSIYGTPMSHRPKELQESQRMSSFVTWPCLPSFHCDHRRRAHRVSDGPTQARTSRHVSQVACWPATNAGRKRTNYSNYEYSIHDDPLVEIRHGQKYSGRIGASADSGKPDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVS1</accession>
    <name>A0A4Q9NVS1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_925994</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVS1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NVS1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="107"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="374"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="444"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="536"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="294"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="536"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="605"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU59047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="748" mass="79298" checksum="55AC2BACB613ADED" modified="2019-07-31" version="1">MAPELKPIEPKTPRWEPSADPADIVVPGLDTTAAPYDQIEQIEQLITIKLQNIDANFSKIQHVMANRILPAVKRYAVGTQPVREAAKFWTTFYETAAQIRIPSYEDYSAGQEQTEDEQTADSSQVETESTPAESSATTHSDESDGETPHPDRTYDRTPSEVSFAPGQAAVSSTPADAYRSRSRNAPDNSFANEASEPMPSWSASLESPLRQLNRDIQSLADDRSVAVPSTSALNHSEAFDDSQDVTQRATGRDSTLDDHTALHTGDKGKAREGPGPQPLLQKVLHRNANSSNLTSATGTTSRTTSPLKFKPKTPVAKTLNPYLPPDTKPSDWKGVVDLKDPSVASPQRSARKFVPPPSSSIKLSAYMPSAAFTARAGARSGTGPGTKTPPPGEDDSFDENFGMSPPVMTDYARLPKLGRTPKQEAAARIMKDLVDVERRGVFGPAGAAAKGKGPAGTGYGTESSMSSMPTPPSMTRYGRPSYAPPVASETSASVVDASLDSIMRRVGLNVPGYGSQKAVLAPAPVAQPARAPVFSSISSASASSATGSSASSVFTATSSRSAASASSARTLQPPAPDPEPSIHTPQPPQYDFYDDEVIGRGGPGDGDDSLDSLDYEDQNTANAPADFLFANQEQSFDSEDSFDSSLDGDDEATDGTAPPFIVTAQDDGDEFDDDSYDDGLDALGGEEETVFGVPPAQRLAQQQAQMAMSGGGLRMLGEDLLQDTIGIGQQMAMAGRVEESPTPWVPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVS4</accession>
    <name>A0A4Q9NVS4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_727105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVS4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="320" mass="35274" checksum="4A54149392F4F6D5" modified="2019-07-31" version="1">MKKDSGGWPVFAQSFPSKPKFHPDQIPDHSGRVVLVTGGNTGIGYETCREMLKHNAKVYLAARSPEKAAAAIASLKEETGKEAIFLKLDLGSLASVKAAAQEFLSKESELHVLFNNAGVMRPPIEWLTTDGYDLQFGTNVLGHFYFTELLMTALLVAVKTSPDGHARVVTTSSSGAYLNTLHFETFKDGPERRKMGSNGLYNQSKHGNVVIAREIAKRYGDQGIISISVNPGNIQTDLQRHFPTVARVILNAVLLKPVQYGALTQLFAGTMPEALKYNGEFLIPWARLGKAHPECYNDEVGERLWSWLQGEVQAFEARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P0B3</accession>
    <name>A0A4Q9P0B3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923259</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P0B3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="518"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="539" mass="60963" checksum="0563BCB32BF520FF" modified="2019-07-31" version="1">MDVEQIAASVDRLPPELLAYIFQVLQLLVGWPQLPNCSGPTLSEAATWIRVTWVCRYWRCVALDCPTLWASIVDSGWWNNTTWLTTFLERSGETPLQLKLDDDDADLEAAVIAIRPLIHRVRRLELWTYDQPLSSVLAQLPGRFDVLEEAELSSCYCDPSDDSPVDDELHLSPGHFPSLRSLILTNAHPAWETFSLANLNEFHVIDASTSPSTAATLRLMRDSPHLRIFKLDFTKLAPSLEPPYDAYGTISLAYLKEFRISGTPREVTYVLDRIIVPSTCSIGVCYTWNEHPGALSLIRSMFPYQLAFKNTVPHYVALTLHLGDDHVALFCSRGDGNSVMSLRVSREHPAVQSIVAEDTWSSLLGAFSSSPLTRINMWFYSDTSISFPMWITLFERFPLQTVQIGFPYTYSSQLWRLQYLFDALRAPCSSKVRLLELFDLFIDAALTDAIIDLLERRAATNIRLDTLMLFGCYLEKSLEPQEFKRRLEPYVKPVFKYRGNHYWGAYAEVDYLRISHGPSSSPSSALSSLSSSASSASED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1U1</accession>
    <name>A0A4Q9P1U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1U1"/>
    <dbReference type="OMA" id="ICWVTMP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="378" mass="42092" checksum="6BD11156754790D7" modified="2019-07-31" version="1">MSSPVSLAANVDRETQLAHSMGAVLIGSLVGLFLSGAVTMQAFLYYQLYPKDMLRIKVMVLVVWVIDALHSIMTMNANWQYLIQRFGDWDTTDEITWSIAVSVALTATITFFVHCFFIHRIYNLSHKNMYITAPLVALALVRLVTACISTSEMIRLRSYSGFVHGYDYVFTIGLSTAVSLDIFITIGLCYYLRRGRSPLSSMDRIIDTITLYTVENGMLTCITTIASLICWVTMPTNLIFLGLHFAISKLYANSFLATLNARKSLLNKSQGSTGDHPLPVLFPSHYPARRATLGPWSQRSQTETHLQVTIEKTVQRDVDEIEGGSTPRGAVSRSGRETPTIDLDDLSKSPPAAYLGEERAPLQTDISWRTRPKGPGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1U3</accession>
    <name>A0A4Q9P1U3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_906715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1U3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="441" mass="49540" checksum="DC78196FAC553C22" modified="2019-07-31" version="1">MSSKFDYLERPEVIGRFFYRLSRATLRGRGYDPTVARASIEETTVFRGLSSRFAPDSTEVKALENFASAGWPIHKITINAPFSDGEKAVSRHDATLERHFLVGKPAFMGRSLVGRGTKAFVAYDMMNDRVIFIKNGWAARHSITTGVLYIPTLLGGGDMMFRAHQRAWEEAHILHGDVSAGNILIYDSADGPIGLLADWDLAKTQKELEKCLVTGTWPFMSACSQQFPDMPHTLADDLESFVHVLNWCLLKYIPTTWYTDRKSVAKYIASVYDFATAEDPEKGSSEKYFKIKYGELFVHLQTNHRINPSLRGLAELCRDHYYHLSLPDLRIDDGLKHIPAPSFRVPKSLRISQGLPSVCTPASDQQRDPPDASKSPLLTHHEMGALLLYTSCIEYWIKEEKYDGHDLILWDDQPSRSSNNPSTEPKDASGSDRSEGGSAQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2P6</accession>
    <name>A0A4Q9P2P6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Complex I intermediate-associated protein CIA30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_809674</name>
        <name evidence="7" type="ORF">BD311DRAFT_712809</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CIA30 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2P6"/>
    <dbReference type="STRING" id="114155.A0A4Q9P2P6"/>
    <dbReference type="OrthoDB" id="42561at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF18">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="6">
        <location>
            <begin position="39"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU33598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="270" mass="30189" checksum="0E0AED910A715EB5" modified="2019-07-31" version="1">MSRLGQYLNRSSKLLRDNASRILRMEGAEEPSRAPKRLFTFNSREDINQFATGCDADVGGLSTVHFELDESTAKPSTSEKTATPHGITVNQPTGKFWGEMSLAVRRGLEGQIRGGYAGFRSKPRSTLFGEMTEDVSNHEYLALRVRALGHPRTRNSYFVNLQTDGPITTDLWQHRLFFRRDDGGWEDVFIPFKDFVLTNAGELVPHQVQMYRERVRTVGISLLGGNSGVEGPYELGIDSISAVNIEDVTDISALEKVPTDGTQWQRPPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6V7</accession>
    <name>A0A4Q9P6V7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_451082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6V7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044508">
        <property type="entry name" value="At5g50450/At1g67340-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46758">
        <property type="entry name" value="MYND DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46758:SF2">
        <property type="entry name" value="OJ1485_B09.11 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="398" mass="44803" checksum="EBBD855B52B976AE" modified="2019-07-31" version="1">MDKRMGMEAFMGVGGGMISEEAARNLKKGEDLCRRRKPEQALPYLFKAMEDPNNLDAIVQLAFLMPTMDIGIRLIEEGEAKGRAQLRQILGPTCFDDDDDNVGHFWGLIETRPYMRVLQAIVRLAFENKDYNKSANAIIEMLRLCPGDNLGQRYWLGSVLLQANRTADALSFAQDWLDPQYRGSWPPRGGCAFRPPSQTPLSAEALEKVKNYGHTGVVYTAALASYKLWGDCDIARQYLRCAAAVNPHVLLKILARVDQPKSLNNLPRSLNGPEDAHDYLWLTQNLWMPSHIWNWANNDPEVKSHVLRTCARSGCGAREVRAAEFKRCSGCKEVIYCSPSCQKEDWPAHKKKCKEHQQHKDFMKALLSGRRPPRPVDPDAPMVASADFSSDGIATTFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9K1</accession>
    <name>A0A4Q9P9K1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_913586</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9K1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9K1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12619">
        <property type="entry name" value="RRM2_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12622">
        <property type="entry name" value="RRM3_PUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000134">
        <property type="entry name" value="Nuclear and cytoplasmic polyadenylated rna-binding pub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF5">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="395" mass="41915" checksum="3BF184D848C80780" modified="2019-07-31" version="1">MLTEIFAVAGPVQHVKIIPDRNYQHGGLNYGFVEYMDMRAAETALQTLNGRKIFDTEIRVNWAYQGQQNKEDTSNHYHVFVGDLSPEVNDDVLAKAFSAFGTLSDARVMWDMNSGKSRGYGFLAFRDKTDAEQAIATMNGEWLGSRAIRVNWANQKTQGAPPAGPPRTGMGGGAPAPMNFQGGPLSYESVVQQTPAYNTTVYVGNLVPYATQADLIPLFQSIGYLSEIRMQADRGFAFVKLDTHEHAAMAIVQLQGQMVHGRPIKCSWGKDRDSGAALSSGSLSPTPTAAPYANVPMYGMPQPNTYGQYGFGAYGGFPNQPAAGTPGAAAPGMGSPVAPSAMGLGAAQSPVDPTAAAQAAQGQWGGADPSSYYSNYWGGYYGQQAPGAAAPDAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAP6</accession>
    <name>A0A4Q9PAP6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_941647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145287">
        <property type="protein sequence ID" value="TBU51770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAP6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14313" checksum="BFF9AFBA17EF246A" modified="2019-07-31" version="1">MQPVRRQSSHAAREPASCDGKLKPNPGRDAGSPRAREWNARRDRSGCQLERSPRSNTNAIPERPHRRGDRIGTASLSTIQYLIMTSSARTGMLRSSPRPPARFRVFCTSRFAFFSSPGCLGVCDRARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBU2</accession>
    <name>A0A4Q9PBU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium:solute symporter family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_941190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145272">
        <property type="protein sequence ID" value="TBU51998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBU2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBU2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="629"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="662"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="570"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU51998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="701" mass="75319" checksum="39634B63335985C5" modified="2019-07-31" version="1">MAVSDKGYSILSFLRVCAYHTSYPYSSTLLVMESEFRPLLDQSVGYGVVVGVGFFFAALMLALTALQTKFSRFSPSSSEEFSSASRSVKPGLVCCGIVSAWTWSATLLQSSTAAYTFGISGPWWYGVGGTIQLAIFGMVAAKVKMNANGAHTFLEIVKVRFGTGAHLLFTFYAFLCILVVCGSLLLGGAATVNALTGMNIIAACFLLPIGIAVYVIFGGLRATFICDYAHTLILFVIIYFFFGKVYGTSEATGSIGAMYDLLVQAGKDTPVVGNTEGSYLTMKSNQGLVFGAATIMSGFSGVFCDQGYWQRAIASAPKSTTKAYVLGGLSWFAIPWGFASCLGLAARALVTNPKFPTYPNPLSISQTSAGLAAPAAAAVVMGKGGAIAILLVVFMAVTSAVSSEMIAVSSLFTYDLYRTYFRPKATSAEIVRVSHYFICFWAIWAGCWATILNAGGVDLGWLFYVQGVVLSPAVIPITLTVMWSKLTRAGVLAGSIIGAILGMLAWMIGCWKIFGVINITTLAEPYSAVCSALTGLLFSGLITVLVSLAKPDKYDFTGTRAIAMYDDASRNDSREDIKPEESGNSSPIETSPVVDKEMSEDSTTAQVLIVQGDGQAVSSAELRSVFKRAAWYSLLLTVIVCLVVPFPMFFTQYVFSKGFYTFWVACTIIWAAMSGVFCMVLPLWESRKEMMLIIRGLLRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCJ0</accession>
    <name>A0A4Q9PCJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alcohol dehydrogenase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_982354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145289">
        <property type="protein sequence ID" value="TBU51745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCJ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020549678" description="Alcohol dehydrogenase-like C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="25753" checksum="145139464EF1F518" modified="2019-07-31" version="1" fragment="single">AFAPRGSTATIPLAFATAVTPIWASEDGAKSVRFTPPWKAGGTTKYAGKAALVLSGSTSVGQFVIQCARMQGFAPIIATSFPRNAAFLKSLGATDVLDCSLPPSNIKSALSSLAGGKPIEYVYDAWGRDGESARVGYSVLARGGAFATVIPQELTDIADLVEESERKGEGKRIAQAWGSYNVPGNKELGEEIYKRLTGWLETGAIVPNRVEVLPNGLVGVEAGLERMLMGQVSGVKLVVHISETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCK6</accession>
    <name>A0A4Q9PCK6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_940126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145248">
        <property type="protein sequence ID" value="TBU52499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCK6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020768284" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="86" mass="9672" checksum="903F29E118C01C0E" modified="2019-07-31" version="1">MFVAAVTAWHCYILVILLENRRTGFGYATQNTARGPCRDHVLLKHSSTTGSEHQAEVYVQFLDMSVWCGHDHKVEDIVGARKPEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCQ7</accession>
    <name>A0A4Q9PCQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_833522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    <dbReference type="Proteomes" id="UP000292082">
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        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
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        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
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            <begin position="255"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="700" mass="77467" checksum="99B71137EAE2E23D" modified="2019-07-31" version="1">MNLSSPDDGRVLTTSTPTSTQGRGHGRGRGRGRGRGRGASSPPRRALEDPSTVGLRDSGSPDARHTTEVDPDDTVPKPRGHPYETRTANTDRNPGLYPGLNWREEKADNERKAAETHAKAQESAKRKAAKVAQNEREEGGSRLLAALEDARYLEDKEEEAYLVRTTVSAHNARIEGTSSTPTTTADASMEVSDQTFGHAGIRGASEDLFEEDEEEYEEGYSGEDETQSRQVRHKMERRHEVLEKISRSRRLDIEGAHNLRVKTPVKRPAEDVEGGKRPQKKQTFSAFNNDWAAISPVGSRSSSVALPPSSSNSRPSSLSRTSSRAGSQVNHSKTGHWKSVLLSKLGTTATFNDGGVNKFPQGSKTSKPATIVLEEEEIGGLQDHDIEFERPTGPTSSTSVRPTVEFYGEISSLAKAKRTAKKDVPEDQSLSADNLPAWIKPAWPQISASLCAFYGAEENPWVLDRNEQDPAHFDNVLKVLIDALFPEKHYIADSSDQVFKVARQAVYNWRRAFANSARAAVKQALKARNGNIRQATRESVATWAKAANSYGGEAHWENPDTRMDGEPSGALQSRYVLHSFAGHLRRTEKSIFSNLGLPVGALTLACTAVNYAFRHYYTGVEAVPKGLRRFDYDTIGHLMEEWHTSTVAPLAETKEHRFKALIARAREWNRTNDSDLQPGPMQPERRRPVMDRDSSPIMPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCZ9</accession>
    <name>A0A4Q9PCZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_952695</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145248">
        <property type="protein sequence ID" value="TBU52508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PCZ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
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    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
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    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
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    </dbReference>
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        <property type="entry name" value="EP450I"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU52508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="428" mass="48153" checksum="0D6184702FE9C227" modified="2019-07-31" version="1">MSKTYGDVMHLNVMGQPVVIVNTFRHATELLDKKAANLSSRPESAMFQLLGLNKYMVFMPYGRSLREHRRAFRGTYGPDAIAQWQPVQLKTARTLLRRLLASPKDFLSHLNLAIAETSMRVSYGIELKDDGSDREYYEMVERVRRIAEPLLHPGAYIMQAFPFLLHLPSWLPGLHIKRNAMEQRRDIDAITDKLYTVAATADENGSLRDSMVARILAAADTKDVHAAEVREMGRTLTAVAYVAGSDTTHAIMEAFFLAMAMHPDKQRKAQQELDAAVGPDRLPTFSDVGSLPYLKAVVKETLRWHIILPAGLPHVALADDEYEGYCIPAGTVVNQNIWAMSKDEREYPDPHAFDPERFLPSEGNPPARDPAEYVFGFGRRICPGRHFAEASLSIYCASVLHVFDVLPPSDERGRPVKMQYRPTDDMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD29</accession>
    <name>A0A4Q9PD29_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_912833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD29"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU66128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="174" mass="18680" checksum="5E9ACBAAD95BBC4B" modified="2019-07-31" version="1">MSDNFAVAATPQAHDADIEYFVRRGMTKGYQLMSAVTPIVYTVFAATRYGRAHLNVNRLLRATWMGGSLGIVGGGAFEYARSAYSNPEKVRIRRFRTAYDTASIRADDHSTIGGILFAVITPALFWKRANSINLILGGAGVGSAIGLIAHHARTVTGDPAPTIPVPEMPPVAPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD55</accession>
    <name>A0A4Q9PD55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_909932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145239">
        <property type="protein sequence ID" value="TBU52729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD55"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="606"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="698"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="810"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="826"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="887" mass="92693" checksum="7049F35F8944B133" modified="2019-07-31" version="1">MAVPTQVLPSWLTLSTTVVTLPDGVVSTSSTTLQLPLTYFGPSIPLGTDGVWTWGGLTPPPSTISASTTTTATPTSSSPSSAITSAPSTSTTLSPTSASSTPSSSILSATSSTASSTSTIPTASPAAGSSHGISPSTLGAILGSILGTLLLLVLIAIIFLLRQTRKRRQVDPQDPSSSFWNRSTTLMSMRRSQQPIWTGWDIVEPRDLEPSPPRSPGEGSPRESGDEEDPFLTRGSIRSGTEAGHTRTDTDTLVSLPAIARTGTVSSYRSKARPGEPIIPRDVQLRMGEEMADAPPYPSIRMVERRPSTDVESPLLPPRPIDPDSLGVAARRASIPSLGSEKRSIVSDKSLGSLDLQEAEGAEMLTARRVKVAQIQPGTVGASTSAAAPNVLGLDRLANLGRLSWFRRMSFLGTPAGSQLGTHSEQEGEPSDTYTRTPPRHSRHGSRSRPGSQSRPASFRISTHEPTSPTTDSFGRRIRQQDAGLGFGMGGERPISSVSAVSEASGNTVFFDARSRPGSSLGTRTTQGSGPASVPPVPPMPAAYPAQPSPLQREVRRSGSGSPGDSHGHFAGDSPPTYEAATRPHSVAVECSDIDVLDMPAPRPASPFSAASGSRSSPPGLPDISVWRNSIVSSTAGPATIATDSTSRVDVLDDAPPSADNGWSSLSGGGRHEGRRLTFGVPMVVQPRDALQSERGSLHSMRSHLSPHSSHSPSGSAAASSRHTLTGSNSSRPSGSSNSHSRRPTGSSGQSLAHTNSISFDDHRPGRRHGDVGEVAPPLSAVFSRGFPGTISPPPPRSNGHPDDVVTPDPAYPPGVPLPISVPTPSATVSGTVTSRTTTEDSLTDLSVTTTQTDPITGAVVHLPRLPWRSGAEAPWGERPVREDTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFL1</accession>
    <name>A0A4Q9PFL1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_937692</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145209">
        <property type="protein sequence ID" value="TBU53628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFL1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7481" checksum="B2E639F652580A62" modified="2019-07-31" version="1">MATLHSVLVSAGSPGEAVDLGNRVQACDAPFHTRHHWATRHDLVFGCALVVSARELCISSRARVSRSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGF8</accession>
    <name>A0A4Q9PGF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_832353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145253">
        <property type="protein sequence ID" value="TBU52387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGF8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="82" mass="9164" checksum="6CEF285D7DAACFF7" modified="2019-07-31" version="1" fragment="single">FDNVSQTSDVPARAILAKRVKSMPGLAHHTAQDVCSWFATACKRQRRKERADSLVRARNLPPPRGVGEGEPGAGEERYRCRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI52</accession>
    <name>A0A4Q9PI52_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_829594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145208">
        <property type="protein sequence ID" value="TBU53641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI52"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="28"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="404" mass="45602" checksum="7756B89C14AF0EF4" modified="2019-07-31" version="1">MNGLNATIPEDVRAQANVEVYELRTTFYVGLASYTVLLYDHFLTLGDEVKYIWMKRKRSPLVWLFFLNRYLTPLAFIGNLYAYFSNTLDYDKCKHFVRYEGATTVIGINIASLMMLLRVYAMYEKRKAIVAFVALVLALELGTNAWLLTNGIAVHHTPHIKGYQACTMIFDTSKVPGVAASASAWTPLVFDTLVLGLTMYRTYSGIRKPTVGRTMWILLKEGVMYYSVIFCVTLVLTLMIVFAPPGIQNLCAQMEYLLTVVMMSRITLHLKRAAHKQDSLGSTYDLSSSSMMISSGRSGSPIAFAPRLPTGHSLNTAFNISIQSQTVMHDDHGEELSDMPRRKTSLPHAPGLAHVVTPPRTTRRPGRAGHGPGEWYEFAPLRFQADRERELERDRKVRLDRDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIC1</accession>
    <name>A0A4Q9PIC1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_909254</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIC1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="3">
        <location>
            <begin position="115"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="704" mass="77859" checksum="6371A0DE4A147FB5" modified="2019-07-31" version="1">MASHNSIEVEHVGNVSPSMPGRDQGQSQDISNRVSDNPGLTGQQRDSQVEAGQGSLPVCSGALPWKIPDSKVVLEHVCDQIILKSVHIQALVKEFRETYTEAEKEKAFASTAKIVQGYSDALVKRWNEEIDMLLVYAGLFSAIVTAFNVQSYLLLQPTPDPTVAVLQQISFQLNSFSVNPPFVNATQPAISLTNVLPPPVESWAVALNILWFSALICSLGSASIGILVKQWLHEYQTGFSGTAAEIARLRQYRLNHFAGLLVLLWNLHRLVAVVASVLVCVVVLFVAVTTVMPIIWSDCCYLSPPTYALLRTKQRLRDTVGVLHSVVFRFLYRYTLYLETIERSPQRAQSLFLRLRHWTMRQSWSSMSSPTWSAREQSIVKGSSLELDVDMIIEAYSSNMDANHLSATAGVILADQDADSDVGYFRSMEAIYTRHLRDSQLASARSPDFLAHALMFSSCNETPPAAPAIWILPNHRLLLALVAIATDPDAEPGSRRRCLQLLAVLFSSDTAELEVIPWKLVRYAAVAVERWLCEELRPSDDRLVDWGDAFILLWILVQCCFAPVSSWERSQEEVETLIACIFRMGVLRKELLLAITRGQLRISLISMSDMSSPGDLLEAVTEVVGFVKSQVAKAHSDDSLWLGLAEDSKILEQTLKRSEALSGVGSGDNGRLDSIPQAAGLGGMQNPRMSVVDSTLTYLIVITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIF5</accession>
    <name>A0A4Q9PIF5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Extracellular metalloproteinase</fullName>
            <ecNumber evidence="13">3.4.24.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fungalysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_830406</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M36 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="13"/>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIF5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09596">
        <property type="entry name" value="M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011096">
        <property type="entry name" value="FTP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050371">
        <property type="entry name" value="Fungal_virulence_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001842">
        <property type="entry name" value="Peptidase_M36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33478:SF1">
        <property type="entry name" value="EXTRACELLULAR METALLOPROTEINASE MEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07504">
        <property type="entry name" value="FTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02128">
        <property type="entry name" value="Peptidase_M36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00999">
        <property type="entry name" value="FUNGALYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021008274" description="Extracellular metalloproteinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="FTP" evidence="14">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601842-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU53256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="610" mass="65512" checksum="1D0C9C5F9B778330" modified="2019-07-31" version="1">MKFWSNFLRSIFLAVVLATSATASPFPASLKHTTLQVREISPGVVVESFHPESSFETFGVNGIDHPLSAREEFDLKDATVSFIQSRLNIDADSISFRTGFSSDVAQHAFIRQQINGIPVANAVANVAFNMANKVVSFGSSFVTTPSNVPSTSPSISVEDAITNAESALSGKFNEHPPTVEFVAKKDGSLALTHVVQIQNDTTGAWFEAFVDAHSGELVQLTDFVAKASYLVLPITKETLLEGFEVLNNPQNLAASPDGWHSDGTTNTTSTAGNNAVAFKGAQTNTTTQSSVGLNFIFTQNPKAAPTTQANIDAARTNAFYIVNTVHDISYVYGFTEAGFNFQNNNFGKGGAGNDRVTISVQDSAGTDMAKFATPPDGQSGRMRMFLWDYTNPQRDGALENDIIVHENTHGISNRMTGGGTGRHGDLDMLNVGSCLQTNEAGGLGEGWSDAMAEWTEHKNATVVDFVVGQYVTNNPAGIRSHPYSTNATTNPLRYSSLQNLTEVHGIGEVWANMLHNVYAGLVRVHGFSGTALTDPTTTGGNTVFLHLFLDALTLQPCNPTFLTARNAWIQADKNRFGGKNFCTLWTQFASRGLGVNAAAYKDDSTVPSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PII9</accession>
    <name>A0A4Q9PII9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_909425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PII9"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038213">
        <property type="entry name" value="IFI6/IFI27-like_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="19799" checksum="68C4871E65E3F6A2" modified="2019-07-31" version="1">MACFLPLDLPPPYSHPREDSPPPRRPCTCPSAQHGAQAAPATAPPPEGRDWGKVALGAAAVAVAVPTPAVTGAAIALPAIGFTSGGVAAGSVAAGIQSMFYGGFTCGLFSACQSLGATIVAPSLASLATAGATAAVGGAAIGAEISKNGSGDNGNVGNGGNTGNGANAGNGGNAGGGGDATLVNCSCVQLRGLGLWDMVSFKAELAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIL0</accession>
    <name>A0A4Q9PIL0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145204">
        <property type="protein sequence ID" value="TBU53806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIL0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="345"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="411" mass="44425" checksum="8433FAF663C3F8C2" modified="2019-07-31" version="1">MAERNGFSHASTGSSECEAPHSPNIQPIADDTAHATSRKRKRTEDLVTVPSISVIVSDPATDSPTLTPIILPDIRHHPDEPYVTPPSPVPTEIVEEPAESTPEEYLAATKRSGVKVRDFAYEPRPKGRDIRAPETWSKPLDTLVLHDRYIRLEPSSARYGPGLPGKMLWGLLSTGLVTREEAEINWRPEAEWKAYNAYVNRPQGPHPIALPADFKKPTAAYRKSLLESSFHSPFWAEDVRSELEIYIPPDVEGMVDGPKNLPDSRRGLRRIIRAPPNPQYVAVYDRPEQPAPTRSNPLPALSTPSQPRLATPSASSAGHNAAVNSVHVDKRRRTSGPAATPSGIGASATPPATSPGGTPSNVGGTLSRSVSYGSLSGSSARSETPPVDEAPHRPLSGNLARTSTLSRIPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIM0</accession>
    <name>A0A4Q9PIM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_990152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050466">
        <property type="entry name" value="Carboxylest/Gibb_receptor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024:SF624">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23024">
        <property type="entry name" value="ARYLACETAMIDE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="110"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="326" mass="35590" checksum="530DB0BD744C2BCD" modified="2019-07-31" version="1">MDVVATFKETTIPVILDPTKHAFTKILENRRSEIEGYPHQTFQFGTTYRHQLDVFYPDPAAVSSGGPIPVLFFVYGGGFTSGDRKQAPPFDLGYTNVGVFFAKRGPSLKLPVTCSILTVIPDYRLHPSVNYPAPVEDVRDALAWFLANPSVVTSASNGTLSSTADISTLFVMGHSAGSNHVASLYLSPSLLPIDSPVRAATRGLLPAGGAYVFSFPNAVTPPGLLEAYYGSQEAALENMPLTLLKRASEELIKSLPLFFVLKSEHEPEAISKGNDEFVEALEGRLGKKVQYEIMKRHNHISPHWALLSGDGEDWGEDVAVWVKARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIV5</accession>
    <name>A0A4Q9PIV5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_829022</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU54001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIV5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIV5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="164"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="182"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="242"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="407"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="470"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="601" mass="64625" checksum="2D5215064E28F773" modified="2019-07-31" version="1">MNFSSSELHSFWDINAQQPDTFSALPDDDFLAFLQKQFPSVGSTNPPLSIDNPDGVDPQSISSFPPNLSPPSSDSSPSPPSTHNESSLSRRQSGVFGNGSTDPSEDSSLKRKASNDNDEEPQSKTQHTCTHLLVLTVIPANSSNSKKTVSSASARRKPGASQDESRLLKRKEQNRAAQRAFRERKEKHVRDLEDKVAALEAKNQLTEQENENLRDLLTRLQSENMMLKQAAFTFTASRPNNAGNNHNVFNNNNNNNNSSNAFSFSSPGAGPSKSPMQTQSPPSQYDLNFNSLISFDPSMLNPADELQDVNMDDPFSFDHEYKTIASNPLFTSFVEPSPADSPPILMNGGQQYVPAPFESTFVEQWTPSDSQSSGQDALEQLFGGSFLGNGNGNSTSADYHALLASPPSSLSPVSHRTPSLSSSSSSPSGAANTGSPSTAAHSPQAGASGTGNNEQCPKTKQQLEKAIASAGQSSFVQTPPFLQNGTSSSPASDEQQGDSCDMPIAPFLRKATGGDGGTPFVMCKGSSFPKTQKSDKNIEVLTAWRTITSNPQFKDVDINELCTEFTSKARCDGTKVVLEPEGVHHIIETLAARQAANQTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMG6</accession>
    <name>A0A4Q9PMG6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_684247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMG6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="7061" checksum="7E802B85A723C185" modified="2019-07-31" version="1">MLSRRLSPNLECNSRCNVFMFRCVSLYIEMIRVTDVGQTPLFAAHSLPFDAHLPFPDRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP24</accession>
    <name>A0A4Q9PP24_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_883397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU55986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP24"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="138" mass="15493" checksum="5EC9E8B230DB854D" modified="2019-07-31" version="1">MGDHHRIRRPRPTYVASRSPSPPSGKRPRKHNPHQAGQASSRDRPQPDDPRRRQDHREPAAGTSVWDEHADARRPPLSIPSRPTKTWDNEWYPPEGAELAKDPEAYLSSPDSTQPRPREPASCPHPSNLVQPPPPASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPF6</accession>
    <name>A0A4Q9PPF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_642489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPF6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9340" checksum="D17D9338518ADD87" modified="2019-07-31" version="1" fragment="single">LNHSLLDVCHTALSVSASALTRIRAYVTDSEVEDAEEMSTEVQPPKLIPLAVLPTIWNRMSCVLRRVDKPHTARTTRTTGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ19</accession>
    <name>A0A4Q9PQ19_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_613664</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
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        </source>
    </evidence>
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        <source>
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    </evidence>
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</entry>
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                <person name="Riley R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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            <strain evidence="2 3">CBS 464.89</strain>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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            <begin position="1"/>
            <end position="18"/>
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            <end position="484"/>
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            <begin position="472"/>
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        </source>
    </evidence>
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            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU57206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="484" mass="55031" checksum="CFCADCF465AD8344" modified="2019-07-31" version="1">MRLSFLLLALTAGTAVHASWFSGNSGNNQPAEYTTWSAKELQNWLDAHNIPYPSQTPSQAELQSAVQAHWDTASSWSADQYKKAQVAFSNLKGDAFDTWDESRLREFLLEQGVVNPSGPREQLALLAKQKWRQYSSAASAYSKTASNSASSLSSSASKQASTAIYGDSWYQASKSATSFAAQATDNVARTFDDSKDYVYSTWDDNRIRSWLEEHGVVEPPATPRSKLLAKMKDVYAAVTNPVWEAWSDSYMHQWLVDHNILKDGATKRREELVQLMQDYYYGANDKVWDTWNDSQMKEWLVQHNVVKSDAQLKREKMQKLIADNYAHAYDTAWTAWKDSDMRQWLIDHGYLRSDAQKTRDDLIKLMQEKYNDASSKTADYLTWPDARLRAYLRENGVPEASIRPASRDKLLQEVRIRWYQAEWHASSLWRKVKSYFDSGVEVAEDKLGMILEILSGGAEGAKEGAKSGAYESAEKHQETSKVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
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    <name>A0A4Q9PSM3_9APHY</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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    </dbReference>
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        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
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    </dbReference>
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            <end position="371"/>
        </location>
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        </location>
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        </location>
    </feature>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU57365.1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="389" mass="41229" checksum="9C02EE0B3B868514" modified="2019-07-31" version="1">MSSSATSDSSLHSRPDKRAATPEHSPAPKRSRPAVDSPWSDPATPDVAPDADGPNADLDSSRVQLPSLASAFTDRHDHRRASLPTLYADNASARPRLPYPIHRTTQSSSGLSSYQFPGSDQSADADTKPARPRLETDTQVGVYPGPVSDNLSSLSSAALSSGTSSSFGYSPLSSSEFSTSSSRPTLSPSGLSDQDSWAAASIARPNSTPGSTHKYDDSLRHQSMYGGVQRISGQSDRSPVPRLNPQDGNALASIKTENGWTFPTTTPDFNMSPSSSASALTAGAGPGSNPAINVTNSPSRSPQAAPAPNPSGLVDRPPQRKRGKLPKPVTDFLKDWLHRHSDHPYPSEEEKKQLCHATGLSMSQVSNWMINVSLGPVVCVKVSLTLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PTS4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15000" checksum="EC1DEECE17ADCFE2" modified="2019-07-31" version="1">MTRTERASYPDAVNKDRSQAKNGMDKRIPKKGAGPHNWGRIEDELEIEQAALQDEEAEFEEATSAVSVNNDAERPAPQRRGSSLSPEEVQQGIEFRKKALKSPNTDLGSIARTAPALSTSPKYDVPVVTDANTNNHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU92</accession>
    <name>A0A4Q9PU92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1016639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="36460" checksum="8696FA306625D1CB" modified="2019-07-31" version="1">MDVKYLSGTAGAMLVDQTTDNIVSCFQKVSVINKRLHGSRGVRTRSTDFWAGVLVRAPPNMDEISFVLTEDFHAMGGLYRSNMTPQQRRRLLLALTALLAHYEASPDSDACQRTLLILQKIFSFNAAVLEQVPWEVVQYDIQLELQSLLHWLRKRLLVGGSDGRPSQWDFGVAAAIGVLARCLFAPVSSCARTDEQRDASIVRVRQIIADLEVSLRHAVVNIEGRRYVAVRLIHSAGLVLETLCQSEPALTAVAGNFAAVVEETSAIGNLQASYDPVWMDRIVTVHLRRLMTRLKTCRAAGTESGSNLMKLPLAGTRVLERPEVIHMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVR5</accession>
    <name>A0A4Q9PVR5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_850846</name>
        <name evidence="12" type="ORF">BD311DRAFT_43774</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143490">
        <property type="protein sequence ID" value="TBU23963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVR5"/>
    <dbReference type="OMA" id="AFKLYFI"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF79">
        <property type="entry name" value="LACTOSE PERMEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G01860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="61"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU23963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU58661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="547" mass="60699" checksum="31BA1CCB16234262" modified="2019-07-31" version="1">MSIIHREDSYDEKEPIDSPSSPAKLEDARIVETVFHADLKAAIDNTRLDPWSTRALSLYFICMVGFLNAVSSGFDGSLMGGINAMDQYLHFFHYKEVGASTGIIFLMYIVGNCAGAFFAGPASERFGRRAGMFVGGTIILLGAAIITGAQSRSMFLGGRFTLGFGIAISTTAAPMWITELAPAHWRGRLGAMYNSCFFIGAIPATGVMVGTQTMNSTWAWRLPLILQVIPPTIVMSCIWFCPESPRWLVSRGRDEEARQVMVKYHSNDGQTNPLIELQLKEFKEMIEVRKMEPVWDYSALFDTRNARWRILALALMCLNGQLAGNGLITYFLPTVMANAGVTSTHTKLVYNFANNILSCFGAFSGALVTDRLNRRPRLYIGSFALACLLAIVAALSSKYGEKGNTNVNGAHATITFIFLFGIVYSFTYTPLQALYCAEVMSQKMRSKGMAVHILISNCAGFINTFANSVGLERWGYKYYFVFVVWNVCASVLWFLFCVETRGRTLEELDEVFDEPWPAMASARKRTVALKTTEDGRKVVQVLDEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW23</accession>
    <name>A0A4Q9PW23_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="8">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_948592</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="8"/>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW23"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW23"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF19">
        <property type="entry name" value="GLYCOSYLHYDROLASE FAMILY 61-8 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="7 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020881377" description="AA9 family lytic polysaccharide monooxygenase" evidence="10">
        <location>
            <begin position="21"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="11">
        <location>
            <begin position="285"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="321" mass="33417" checksum="7ED2FFA68FC03E36" modified="2019-07-31" version="1">MFAFATLVALASAALPQVFAHGGVLSYKIEGEIFQGWAPYNSPTGQTTIQRPWSSYNPITNPTDPTLACNDDGTSGALQLTTTTKAGDPITAYWNQVWPHAYGPMLTYLAQCPGSTCTGVNANTLKWFKIDEAGLLSGTVGDGYWGSGKMIDQNSSWTTTIPASVPSGNYLIRFETIALHSLPAQFYPECAQIQITGGGSLQPTTDELVSFPGAYSASDPGLTVDLYTNEAMTQTNYTIPGPPLYGSGTGSPAPPPASTTAVPTTVPVGPSSTSAPPTQSSAPVGTVAQYGQCGGQGYSGATACIAPYTCQALNAYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWM0</accession>
    <name>A0A4Q9PWM0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNase III domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1012140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWM0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20803" checksum="15E4AAA0B60B46E5" modified="2019-07-31" version="1">MLHGLARSRASGKLLRRLATFAQIWGGIASISLLPPAPQIDGEAMLQIFVHSSVKFHGAPLDANTPYGDGKRLAFIGGRALEAAYALISSNKHPLPTAEALEEEVSKLQEQVEKWVEGYKWREMVRHANDVDLRTPEETRYLMDAYVGAVLVGSGFQAVLNWIATLVDPSRAAELVATVPRSPDRRRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXG5</accession>
    <name>A0A4Q9PXG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Fragmin60</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_817876</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXG5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXG5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000002">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF130">
        <property type="entry name" value="SEVERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00597">
        <property type="entry name" value="GELSOLIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="310"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="399" mass="44116" checksum="7ABA252E1ACEE5BD" modified="2019-07-31" version="1">MAHLTRPTQYNIEDSNIALLGSDLEKHVREHAGDKEAAWQASGKEPETQIWRIEQFHVKEWPKSHYGHFYDGDSYIVLHTYKKDPDNEELSYDLHFWLGDETSQDEAGTAAYKTVELDDHLGGKPVQYREIQGYESSRFLSYFPKFVSLHGGVASGFHHVTEPPPDNSRRLYLISSAQVPGKATGHLQVREVPTEGASILEGGVYVLDMGHNVWQFNTRAAPGKVKFKAAEFVQSLVNERQSQCESTVYGTLCPCLLLNHWGTDEHGQGAGLFLSELGLEAVGPPQVVAFATEKALFRLSDSTGQLAFEPVSPPTKSSLSPDDAFVLDDSSNPTNPAIYVWIGANASLTERRLALQYGQHYLYKRKQGGGRAALATHIVKINQGQETDAFKSAIVGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXI7</accession>
    <name>A0A4Q9PXI7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetoin reductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_925259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXI7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXI7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="263" mass="27922" checksum="827C3459B72DC574" modified="2019-07-31" version="1">MASTSPRQVAIITGAAQGIGRSVSLRLAKDGLDLALFDLPKCQNLLEGLAASIRAEHGARVITVYGDVSVEEDIKKLVDTTTEQLGDLYAMIANAGTANVASLHETTTEMFDKLMNINVKGVFFSYKYALLRLLEQGKGGRIVGAASISGKRGSPDQPVYSATKFAIRGLTQSAARDYGKYGITVNAYAPGLVDTPLWTLVDEMHSANTGAPKGSWPGSPPKNALGRVAQPEDIAKLVSFLVSDDAAFITGQSYNVDGGEYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY80</accession>
    <name>A0A4Q9PY80_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY80"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="487" mass="53988" checksum="64FB9F4213AA674D" modified="2019-07-31" version="1">MSPSDTPRSSNLSSVPPSGNSTSSNKRSRTESEDQLRCSPIEQDRVAQRKQPAKPATPLGPTPILRVSLPIPSRSSQNMALASTRYDPGDFSGLPTALGENPHMWRTRRGSPPIAPSNLRDLMIPDTDFPHAHIPAFRIDGNVLEDQVQRIREITNPKVAIVIHGGGQELASAGGLLKEKVLELLSAITFPPSVPQHMDATLPDPNAPSSAIHIHLPIARKSRQSSAFSQPWSWFVDLGPNSQRLYEWLLYHEVFPITPSLSFSVHPFTATIPTVDDHDSDVARKQVLKDIKAFVWMDRDFTVCTTLQVQRNWGLSGNPVTLLKHSTDTLHIVNVVAKLKSSRKEVPAYLVYAKPTSNDKEEYLKWVAKFTSPGAYWRGAFRLDIGKATVECKLCKDTSHCARACPLATDGWTGTVVEDIYTTQELKARAARSSMAASSSSDHDWQRVRERRVDTVTRPHTMGRSVQKSPRKGPRRDGQGKGKGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZN1</accession>
    <name>A0A4Q9PZN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_947444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="352" mass="38259" checksum="1870D16CF45ACAC2" modified="2019-07-31" version="1">MWILLGNRRKRRPNIMMVGASCALMLLSTAEMALNVIRVYQGFVAMGPSLPGGPEQYFENISLPTFVAKSCLISAQSLILDIVVIFRAYVVWQSLPVVILPILSWIGLLVVSIGTNVSLAGMHPSGGLSLQDNPWITSMFTLYLATNLSATALLAYKIWTVTRGTSQYRSSEGLAPVLRVALESGAIYTITMSAGLILFLLQSQLVYALIDISSPIISIVMNMIIVRVGLAAERKKHLRAVPRQSSSGFSFVAVTIPKPHPGYLRERPDAEMALGVPSDRVDDDVEMGNVVMKMERLLQDGGPSTPYSESGTTDDAKSVVDVDDPEDVKSVDLALTSARSSAFHVITERDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZN3</accession>
    <name>A0A4Q9PZN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_905477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZN3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF5">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="197" mass="21578" checksum="BD45481D113A8BA1" modified="2019-07-31" version="1">MSTVELQPIEYNFHFPWRDLENDRVKLVLFDNAAGSFLLLAILDKASPGEPLAGITGFLDADPANLSVEVGVLVCLLAFQRRGLTSAAVALLLQYCLDVPRNGGLGLRRVTYASHIANAASVGFARRMGFVFEGVARWEKMLVEGKPGNGKSVAGREGDPRAGMGGRDTAWFSLCWDDWEGGRREAVCRPEYAMRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q009</accession>
    <name>A0A4Q9Q009_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_340364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q009"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020302122" description="Secreted protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9842" checksum="EFA5549E51140BBB" modified="2019-07-31" version="1">MDVVAWAFWIRLGALVCDCSQDCTTAGKAPGSKQGNLCSIYRQCNLALAFPVGLCIPLCHLGNLMGTLHRPYVQRRFPHLDHRALPAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q061</accession>
    <name>A0A4Q9Q061_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_876361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q061"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="95"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
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        <location>
            <begin position="299"/>
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        </location>
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        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU59954.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="327" mass="35938" checksum="C59A8FA0B62EAEA7" modified="2019-07-31" version="1">MASSRWSFTRVLGGPAKTQPPSNHSTSGPSHTNGNSRGHGPRQHQRQASSATTTVQPQSRFNRPPAATAAVAEDPNHLSNDSTPAVPDSVWFASDFMLGSGMAIIQPSSGKVVILCQREKDRHGREHSYWFLPKGRKDVGESLEQTALREAYEESGYRVSMLPVVLPHNAPNPPGSIRRLDRSRILPCTEPIYISLMGYGRGGRNHQRGEYLTFWYVGQIPADATVEAGTRMADEVDYETHLVTIQEALARLQGPPAHVMHKAYELWTHTAQLQAQNEYRYYVSQLAVEHARAAVASHGARPAGADEVVSAEQAAQDAENWEDADLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
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            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
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        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="419" mass="45481" checksum="910D6B2C00E37340" modified="2019-07-31" version="1">MASLVLVFKQPRTWIPESLASPFKIFDQEHRARWVGSPRCKRLLSGFLAGYLSGPGALTVVLTLVSGVFLGFFVLWVLEVVHENGNCYGECSTTPTVSAFPKSTRFVHSEAVDLEQDYEVSASGSEDHTAPSDAYAHVVGCQLSSDGVVLTVEVALEHALVQGRDVHLELPVDLLELHTGCLAWTAPLASTDATLTSTDATLASEDCLAGYVASPKHQHARSPSATLEEDRHSGAVAVLEMDGDEFKFNPHAPTFVPPSVSCPDPGKHDFLAVHNFPAAAPRDSNRNCPASQSRWPGRPPAPAPAPVHAPSRQLPRARTPGRPNAKSLLLVPQHHNHHRLGPAMLSSSAIRDPTMERYKRICHWRGTAMAARRCKRESIAANADVEAEAEAEREAERVALEVIAKVVDEDEDGCAWMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q118</accession>
    <name>A0A4Q9Q118_9APHY</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q118"/>
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    </dbReference>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="146" mass="16580" checksum="C7C6D60DAC76BDF8" modified="2019-07-31" version="1">MDRFMAGGRASFERDISKVGTFLGQKDLPLMKAMRTHAGRLEQARVRLRSCDAQLQEYGRVEPQVILNAMQCIEKNLRLQPNLLRTSFSEVNRKLSTEMDNLLNALRAVRTNPNSPESQLAIRNARQRASSASETWKEAQSTAFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q123</accession>
    <name>A0A4Q9Q123_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_922479</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
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        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
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    </dbReference>
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    </dbReference>
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    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
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        </source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16654" checksum="93433E2939D29D01" modified="2019-07-31" version="1">MTALRRIQKELKDINNNPIEGLTVEPLEDNIFEWQCSVKAASNSPYKGGTFHFNLNLPENFPFKAPSVTFITKIYHPGINEEGQICVPVLRDQWKPTVSLSSVLTTIVDKVNNPSPDDPFEPDIAALMKNDEAKFLATAKEWTKKHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q177</accession>
    <name>A0A4Q9Q177_9APHY</name>
    <protein>
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        </submittedName>
    </protein>
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        <lineage>
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            <taxon>Fungi</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU60912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q177"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="163" mass="17935" checksum="F3DF2F8BD1652F2F" modified="2019-07-31" version="1">MPTFMSPGRPPVTIARAAWPQRWDVRGCDAEQLTPSVFQLERTLGTSILWSAFACARQGGGEGDFDRSTSPGVTAQRTIGRQRAVEHPSRRSEWRPLYPCIYRSQYVFREMHGVGSREETADPRTGAQQTRTSSSSSSSSSSSSSSSSSRNSSRNKVCVRGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1N6</accession>
    <name>A0A4Q9Q1N6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_271355</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1N6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="99" mass="11192" checksum="E5EE492CECBB96C9" modified="2019-07-31" version="1">MSKVPRLRTMLTTQRPRADPPNVYTRARHGGPAEVRKKRDMDMRRNNTSRVSIHPQTLSVPLNELASAVCAAEARKCGGRSDGVRRAQRRSEVELRSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2E0</accession>
    <name>A0A4Q9Q2E0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_996874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2E0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="40926" checksum="AF7C57A45B683B3E" modified="2019-07-31" version="1">MSDDASARRRERYATLSSLEITWRDRQQYLESRGYMLRRRYRPGWVPSWKTDPSIRPTDAEDSLTTHALRPSLMDATRIADGKLVQLKRIRTDSQELDIARRFSSPEYRSDPRNHCVPILDIIPDADDPQMSYIVMPFLRDVDDPPFKSVKNILDCIDQLLEGLAFLHEHGVAHRDCAYRNLMMDASALYPDGFHPMYTASMPQQIKRPATLLSRDDVPVTYYYVDFGISTRFEPEDTNRLVVGSDGLDQDPPELSEDDPYDPFKLDVFIIGNFFRQQFLMTYANVDFLVPLVNQMVSRDPASRPTAAAALRHWQAIRRSIWSVQQYWRPRPRGEPLIVCAFGSIMSRSTRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2T1</accession>
    <name>A0A4Q9Q2T1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2T1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="143" mass="15473" checksum="5EF247889A270B90" modified="2019-07-31" version="1">MVGQAFRRDFMKQAGVHGIDAELWPKEALWMRHKPVLSLLAPLLSPGVGSAARGPTLLEVQTPSATHSHPSYLLRSPARTGCEARHPCNCQVPYPALRSLPEGLDGTITPHINLWDRAALAAVSCSLNPRCGSCSSSPQIRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4C3</accession>
    <name>A0A4Q9Q4C3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mitochondrial inner membrane protease ATP23</fullName>
            <ecNumber evidence="8">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_965639</name>
        <name evidence="9" type="ORF">BD311DRAFT_746091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Has a dual role in the assembly of mitochondrial ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M76 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="8"/>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4C3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4C3"/>
    <dbReference type="OrthoDB" id="285308at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019165">
        <property type="entry name" value="Peptidase_M76_ATP23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21711:SF0">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE ATP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09768">
        <property type="entry name" value="Peptidase_M76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU34402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU62162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="217" mass="24928" checksum="2DDD4D124A15CAC0" modified="2019-07-31" version="1">MDNRSSTPGPSHADQSLFERWRDKFTAMTVGTPEERVAAMHEHHHKKCEKWKGELMTYSPAVVFMLKHLKQTGADVTSDDIVCAPCDFARAGGFNPAGVIVLCQDKLMSKSHMEDTMVHELVHMYDHVKFKVDWDNLRHHACSEIRANSLSGDCRWSREFRRGFLSFSKQHQECVRRRAVLSVRANPACPDQATAERAVNEVWDSCFNDTRPFDEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q549</accession>
    <name>A0A4Q9Q549_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_95806</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q549"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020670256" description="REJ domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="17821" checksum="5AE7878F8E321CC5" modified="2019-07-31" version="1">MVNFKYTAAFVAVGLSICTGVGAVVAPRPAECVRSGFSSVVTVTSTVTSTVTAAPSGTPGLAKRQEDTTTITTETDTTTTTTTETDTVTTTATAGSLSSSGSSASTTGSSSSVSQSGGNPYFRPHPTRTPRPLFETASSTSSLPSSVSSVLSSVSSSLSSVVSSVSSSVSSSDTTTTTAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q561</accession>
    <name>A0A4Q9Q561_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exonuclease V a 5' deoxyribonuclease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_918539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q561"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="678"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="551"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="829" mass="90763" checksum="91A33CE30F41914A" modified="2019-07-31" version="1" fragment="single">MSEPDEYDAYFVPLNLNDEDLDAIDAAESRARPQSNSTTQDDLSHTPPSPDEFDAYDLSEFSAADLAEIDELVDRLHGHSPLPPIREVHDEHERPSASESGSPRDRSSPRRGGGDVPNGGPAIEIALESAGKADPSRRLKDSWIKHTKRSPYEQFRKWNRLLTVTDIAGPSWCEVQFDYGLRQRRNRKLSDRPASFTTAEGKTITVAHQVAVANNLTVTRGRSVHKVLEREIQQEPVQIEIKTNEERWALRIVNMLTAVQTLMGLGKCREMPVFGFVHGQIVTGIIDEVVRLPLPASPPREEQEQKMGSTSPNKRPAPRTAPSTPAKPSSKKQHKEPTSDQPQITAYFSPTKSQGSTAETAIDVDMEEPTTPAHSQAPLHGAPGSTPPSQLPRYSLHLSDTKTRIRPTLPPEEDTFASRIQLMLYNRLLSGLLATARPDNPSSQPFDFDALWRQVEVDPTRRFSDSFLIQAGLSESQTETQDSTSTESIIDSSEIHCLNDLTRAWRHAVEALNVAGVDKTLTIVYRAQPRTKGRPSANGKKAHETNRDSSESAPSPLSSSALSVSEQEAQDLAAAIQASISDVQPGLGGDDELARAIYESLEDAIRSGRVAEGELGVLTNPFGPPISETSPTLEGASRMGGAAGVEGLSDEFQLAWALQESLLANLEETHVLKEAISHSAASGVDAPVTGEKEAEEEDPSGVALGKLVQRAATEELEGAAESAPSVTGVEEDEDEVMITAADLETEAWIIGTKEFEVDDALLDDYLERVLAWWYGERPPQGVDVGLTRRCVTCEYRDGCEWREKKANEALQKFRDRSGTPLTGPSAPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5F6</accession>
    <name>A0A4Q9Q5F6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_92398</name>
        <name evidence="2" type="ORF">BD311DRAFT_317777</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143420">
        <property type="protein sequence ID" value="TBU28583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5F6"/>
    <dbReference type="OrthoDB" id="3257981at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597657" evidence="1">
        <location>
            <begin position="22"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU28583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="482" mass="51707" checksum="95A846D9CBA463E3" modified="2019-07-31" version="1">MHFRSLLISAGLLAAAAFTNAAPTKVARQSGVPKIVVAHHIVGLTASFTIDDWKSDIQLAQANGIDGFALNVGNDPFTSTQTDLAFQAAEQLNSGFKLFFSFDMSSLPCTTADGGATLRSLTNQFASRTPQLTVDGKAFVSTFAGESCTFGAADVPTGWRTQFTQHPDTVGKVHFVPSFFIDPATFNTFTGVLDGAFNFNSGWPLAISEANAAQTVPDADLTAATFSAQGETELQKFIGAFDPDTSFINGLAGVQGSAQTYMAAAAPWFFTHFGADTFNKNFVFDGDEHLWVSRWETLVANRDKVNLVEICTWNDFGESHYIGPQHGDLPPGSDAWVDGFDHSGFLSLTNFFATQFKTGTAPAISQDQLVLWARPHPKNATPNDPVGPPKDFQLFQDKMWAVVLATADGSLTLSSTDSDAQTFPITAGVNKLSLPIQPNGSLHGVLTRNGQTVIDLQAGNFTFNPNPSAFNYNAFTVHATSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5Y3</accession>
    <name>A0A4Q9Q5Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_871352</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9Q5Y3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000500">
        <property type="entry name" value="ATP-dependent RNA helicase DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000002">
        <property type="entry name" value="Putative ATP-dependent RNA helicase DHX36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF267">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE YLR419W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="570"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="807"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="162"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="756"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU62530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1331" mass="147392" checksum="4F44EB72C30CED78" modified="2019-07-31" version="1">MPPKRGIVKSGNAGNSSKASKPPLIPAPASEEKPLFPPGSKYPLSLLHERCQKNGWEKPIVDTRRRGDGYSFSVLLSRVNKKGSEWESVRLEPHPPFAMPSALEARHWGATYALYRFCNGIQLDRVLPPGPREYWKQLAAEHKAAPAHQSWMYEADPFAARKAVNERQEKAAQKKDEFSRPEGSSKPAPQSSDFANAPEAKMASSLRDFVEDAVKKGLAMYPDAGDAEPNHIKSEDQPRLAKELGLLGFTLVQARKAITALSQASALNSSLLERLPPLQACIEYLILQVPECDLPQRFLPSVNSSNPFITGAHAGTDDLKKRWAEDKAIKECGWPAHVVRECTSDQALTEDWGKLIFALDCRLVGVDWREAATIEPQDLEVIDQEEVEALSGLAGINRELMIPLPVAPLTLHVIVPEDRILPAAGTFPPMYLTSSTVAAYVRLHVLSKLIMALKTGTLRDPGETVIMAIMRHVEEEWAVIQDYGPPDMSVVMRHLLPKAQPPTAQGSTVPTDETTSASSKSRRPRAIRRDDRTGERVKQEYEQLVRRVDYAKMLTTRERLPAFASRRQFLDILKANRCVVVVGETGCGKTTQLPQFVLDELIATGQGAKASIIVTQPRRLSAIGVAARVSAERLEDGSVGYAIRGESKQGSHTKILFCTTGVVLRRLGSGDKLDDVTHVVVDEVHERSVDGDFLLLELRELLKTHPTLKVILMSATINHEVFVKYFHNAPLLTIPGFTHPVEDKYLEDFFPQLKYRPSGPKSSRQARDRDDEAGQELDSAGLDDESQMAIRAIMRSESFDYDLIAATVNHIVGTAKKRGGILIFLSGVQEIRQCMDRLRTVPNSKILPLHANLTNDEQRRVFASTPEWKIIVSTNVAETSVTIDDVIYVIDGGKVKETHYDAEAGLTRLTQQWVTRAAAKQRRGRAGRTQPGICYKLYTRAQEKRMAPFPIPEIKRVPLESISLTLKVVHNDVKTFLSRAIDPPEIAAVDKALEVLEELAAIGSDGELTALGRHMAILPMDLRLGKMLILGTVFRCLGPVLTVAACLSSKPLFLSPMDKREEAKQARARFATDNSDLLTDVNAYEECVNLRNKGESPGIIRVFCEQNFISISTIRDITSLRQDFMFSLSTLGFVPEQSKPTDEALNTNSTNVNLVKAVILGGFWPRVARVHLPKSAIKFDRVQAGTIQRENTAKEFKMYDLKEGRVFLHPASVLFNASAWKSPFLTYFQKQMTSKVFLRDATEVPIYALLLFGGPIIVNHIGGGLTIGTKDCIIKLKAWPRIGVLANHLRRLLDAQLLQCIEEGTLLGLSSGDNPVLQAIQALLAGDGLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q682</accession>
    <name>A0A4Q9Q682_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_918263</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q682"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="374" mass="40335" checksum="4393C6DFD6FB5660" modified="2019-07-31" version="1">MAYQGQTDIVSGEQYRYALTNFRIAHEKVEEQRVQLQEQEKQVALLRARIALLEGTNQNSHLGVSKLGGNSVDDFSIKNAASGLERQINRWAADVTRAPPVPFNTIRQAALTDVFDDDPPELGPNAPNATGIQIQSLLRHAVSKTIAEGIVNCLIVTDSPEANIQLTRIHEHIFSRDATVAAVWRRQTFTAAVESCSEDMSRFFLSEHMPNLTKVLGLDTNAKGTAASGIYLVLEAAYEFSRMLHGAPSSSGGSVDAFYRAFVPDVAITMNPRQIELVKRCHKTERGELDRVGATVFPGLVKVSRGPQGPNGVSTEDVQTVVRRAQVICECALMGTGVVSPGVGMGPGVMGVSPPPSAPPSVSPQPYAHPHGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6E1</accession>
    <name>A0A4Q9Q6E1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_917401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6E1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20252" checksum="87BA830E42FED219" modified="2019-07-31" version="1">MAEKSKGRGRSMQSMRPANGNPPRSPIAELSAAASLALSIPGRSVNTSRSLLLLLLPLPHILLHRRLILRSVFSLLRSRVTSPITCSHRARLLIAPNSPSLRTSTCPDAMHSMMPLLTAPHSIHIDLLCVYPLPLCHPPLALSEQLVRWPREQSSSPRQAKSHRAPRFHVSVRGAASERLSAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q854</accession>
    <name>A0A4Q9Q854_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Snf7 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_973268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q854"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q854"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="202" mass="22969" checksum="AAF6053037A6E87A" modified="2019-07-31" version="1">MGGNQSVPKITKQDRAILESRDEVRKYQKKIQVVLDREHEIAKQQLAAGNKDRALSALRRRKYQEGLLVKTDAQLENLEKLVSTIEFSLVEVSVLHGLQQGNVALKEIHKELNIENVERVLEETQEAREYQREIDEMLANSLSLEDEEAVQAELRELQLETLGVEDAGRPVQLPSVPTERPVSPVKEPEPQPQERERVPVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8D8</accession>
    <name>A0A4Q9Q8D8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GNAT domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_915991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8D8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8D8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328">
        <property type="entry name" value="ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43328:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="288" mass="32740" checksum="E3F76183604F79E6" modified="2019-07-31" version="1">MMRANTRADMDLREPTDNNGLEGDPVETEPCRRTTHLSRMSFSQFHPLERHPRTGEPHIRLTAPFDRIVITPPRQDDVPHIVAILNDYAVKKWLDGPPFPYLDMHAEEWIAKTKEQSDAVMHELRVANEEYSTGPSVAVSGCPVGCLRGVEEDGSEVFLGAIEFSRCNFPDLLNQQEQERMVARNDSRKRGDPDIVWCIGYYVAAPLHGRGLMSRAVRTLLEAWVVPRMGARQIRVETVIGNHGSIRVLEKLGFRIVDTVRRRKVTSAGELIDGFHVLYWHLSEGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8P3</accession>
    <name>A0A4Q9Q8P3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_808827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8P3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35465" checksum="9B9EF65A56EEF18C" modified="2019-07-31" version="1">MSPSNHHYRRNRRRPPPTLARPSKYRTICDLPVELLCMIVSHVKSSRWTLRACTLACHCLRAVSLEHYFNTRLKVRDIRSFDHLISFLRAAPNIREKIRRLELSGQTEIGKVPHIALTSIDDTVVATLMQLLPNLTSLDINSMMYDTPASRSPPHVQQDKPGPFRLQSFSFDFYYTLSHNSSISGLFRILSLFSIDALSYSVRDFDTTSPFDLAFLHRPPEIKKLRISHCSPDENSGTSLLLDAFTESLEPESLESLRIEYGTGPEVLALGKLLARAGKALTSLSISGIHPFMLSERKPWHWVDPLNSMSMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8Z9</accession>
    <name>A0A4Q9Q8Z9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger RING-H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_794747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8Z9"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8Z9"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger RING-H2-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8594" checksum="4E04AEA4341BBE5E" modified="2019-07-31" version="1" fragment="single">DVVVENCAICRNHIMDLCINCQAHQVSATATPPGARVVQACRYADGPCRIPLHCTSRWLEKRNVCSLDNREWDLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q921</accession>
    <name>A0A4Q9Q921_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate transmembrane 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_915353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q921"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q921"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="631" mass="70941" checksum="08D1339DF2D59D98" modified="2019-07-31" version="1">MSTQNAPAQAAPANAGAAGGEEESPFKKFFAIAQQMLLIYAVMQVASRFFGGNKTQQQQQPQGANVANAPQANVPGPEGAVSGIPTHAVPGWPLGLPLAVHVHLSTSPTGDVFSNKWTSGHRKDRDADLPSLVWNNVTLGDWNEKRVAEFNVSLPETVQNNGSLWADVFLVRDGASPDPSDAKFDPRAVHHVRTLLTKYLPKIKARKEKNLLSGSADDTTEIEEESETIVSHWHPTLTLALVSDNPIIQLSQIQPAAARYIHIRQERDDAGRPYYDPIIFPNEFWHLRSQYVEINSTTPTLPLQIEFQPMSMWKFTIFAALTQSFAEAAKQQGSTSMAELDEVKRMLVETNPYFLGLTALVSVLHVVFEFLAFSSDVSHWRQKQELVGVSVRTIVTNVVVQLIILLYLIDNNEQTSWMILMGSGIGVLIEAWKITKAVDISIGPSPPGSRLPYQLIIKDKHVLSEDEKKTQEYDKLAFRIVSYFTIPCLAAYTVYSLLYETHRGWYSFVISTLTSFVYMFGFAQLIPQLIINYKLKSVAHMPMKAMVYKTLSTVVDDLFAFCIKMPFLHRLACFRDDVVFLVFLYQRWIYRIDPNRVNEYGQVLENDVVAAVEGKGKEVKKKDVKESKKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAB1</accession>
    <name>A0A4Q9QAB1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_867674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAB1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAB1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7 8" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU64587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="378" mass="42584" checksum="543FFA81C6844DD9" modified="2019-07-31" version="1">MLSLRLHRLCARSRLQSLARTYSSQSSLPPLPPQEEWRKTFTYQTVARRDRVFVRTPQAARSIAQSLFTRTPAATDKGKVVIEAFPGPGALSRALLELPSSTVRKLIILEDDPTYLKFLEPLADADPRVTVVPMSGHKWDTYSHLDEHGLLDDVEACPWDATIPDLHFVSHLAHNVYGEQLVAQLFRSIPERAWLFKYGRVPMSIIMSEWVWSRLTAGPGTSRRCKLSVIAEATADIQDAFDPALVSPYEAHFYPPPAVYKKGLSRKPGQPMYGITAVPYVDQVIQKGMTDQWDYVLRRLFVLKSTVLKDAISSLAPGAVTLLKVLGDASLPRDQRVNVSKRIRELNVADWALIHRAFDAWPFKPQDLLIGDAFMPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAI6</accession>
    <name>A0A4Q9QAI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_915318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAI6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAI6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10501">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A/U2 SMALL NUCLEAR RIBONUCLEOPROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="263" mass="29235" checksum="DCD4B37BA414DBB8" modified="2019-07-31" version="1">MSSTQPNTTLYLKNLNDKVKKDELRAQLFALFTTYGRILDVVALKGPKMKGQAFVVFTDLAGATAALRGCEGMVFYDKPMHIEYAKTKSYATLRREDPDFVPPTSIYVKNAPNGKLANGGAGEKRTRDDRMDEDAREVKRERTDKDDEDDDDEEMEIEDDDEGPRQGGSTNGQIPAATQQQSARLMCLNLPQEVTDDVLSVLFQQYQGFHSVQVVPSPTPNAAGQRVKMAYVMFDSPDLASVAKEALDGFTLKKGWVMSVSYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC00</accession>
    <name>A0A4Q9QC00_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_914954</name>
        <name evidence="7" type="ORF">BD311DRAFT_756256</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143412">
        <property type="protein sequence ID" value="TBU29496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC00"/>
    <dbReference type="STRING" id="114155.A0A4Q9QC00"/>
    <dbReference type="OMA" id="EAYLGEF"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU29496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="19593" checksum="5F13555313D9C2EB" modified="2019-07-31" version="1">MSNVLRPYLAAVRSTLTAALTLEDFSSQVVERHNKPEVEVAVSKEVLLNPLTISRNENERVLIEPSVNSVRISIKIKQADEIERILCHKFTRFMMQRAESFIVLRRKPVKGYDISFLITNNHTDTMLKHKIVDFIIQFMEEVDKEISEMKLSLNARARVVAESYLSAFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE47</accession>
    <name>A0A4Q9QE47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_902310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE47"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19622" checksum="C4FFA1A4947C2F22" modified="2019-07-31" version="1">MADVPAPSGLPDDTFVEATAASWNPKHERVFNRRHIPSEVRNELQAYYRMFSWPSWFGRHKCRSNNLSAVLSEPMTIVRLPPVNTALHPPPWRKTAAAAMLALEALYLGSMLAASGAPLRRSVNSSTTQKSAPTTLTGFRESKCGECGVRKGIAIVMKIVAVIGGMRSVQRDMRNESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE99</accession>
    <name>A0A4Q9QE99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_912890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE99"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU66162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="19650" checksum="514A9DBC2A7A9833" modified="2019-07-31" version="1">MPIGGVVYTVLVASGDNLSRFLDARDIAKVLRVICSRRRLLQTFQILVRPHLAVLTSLHRPSSGDSVDGCCLWRLSSSKARVMAKILVSQTVVRYNFRGVHRAGAIVRVGLESFLSPGETPYCSAHLLATCILRLFSPWAERLSEVAVLRDGTWIRLVPLVTSLLAVLTLALATENVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K3S5</accession>
    <name>A0A4V2K3S5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Gluconokinase</fullName>
            <ecNumber evidence="3 9">2.7.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_867177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>D-gluconate + ATP = 6-phospho-D-gluconate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19433"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18391"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Carbohydrate acid metabolism; D-gluconate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the gluconokinase GntK/GntV family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.12" evidence="3 9"/>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K3S5"/>
    <dbReference type="STRING" id="114155.A0A4V2K3S5"/>
    <dbReference type="UniPathway" id="UPA00792"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046316">
        <property type="term" value="F:gluconokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02021">
        <property type="entry name" value="GntK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006001">
        <property type="entry name" value="Therm_gnt_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01313">
        <property type="entry name" value="therm_gnt_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43442:SF3">
        <property type="entry name" value="GLUCONOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="229" mass="25148" checksum="7E3F79ABE895A578" modified="2019-07-31" version="1">MPHEQEHHSEQHAPRAPDAPKPKRHPILIIVMGVAGTGKTTLANAIQARLGLPYIEGDALHPAANIAKMSSGVPLTDADREPWLELIRTTAEHMVAEQQADPSYTGRPGVLATCSALRGYYRDILRGTRAPPGLQLPEHVAPAEPHRLPAYFVYIKGEPEVIRERISKREGHYMKPGMLDSQLQTLESPEGEEGVVVVPLDASTEEQTDIAIRELNKLLPEPLERAVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K799</accession>
    <name>A0A4V2K799_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thaumatin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1041219</name>
        <name evidence="3" type="ORF">BD311DRAFT_544967</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143394">
        <property type="protein sequence ID" value="TBU32572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K799"/>
    <dbReference type="OrthoDB" id="430315at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001938">
        <property type="entry name" value="Thaumatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31048">
        <property type="entry name" value="OS03G0233200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00314">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002703">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00347">
        <property type="entry name" value="THAUMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00205">
        <property type="entry name" value="THN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49870">
        <property type="entry name" value="Osmotin, thaumatin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51367">
        <property type="entry name" value="THAUMATIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040685355" evidence="2">
        <location>
            <begin position="19"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="27"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="95"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="148"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="153"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="182"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR002703-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU32572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="255" mass="26691" checksum="178804BCB76C036A" modified="2019-07-31" version="1">MKALSAVVALAVAGTASARTFTIYNQCPFTIWPAIFTDLSRGTATPNQPTGWAQDAYQTVSFYVPDNWLAGRIWARRDCDFSTNPGPNSCLDGGCNGGLECDPHTGTGVPPASLAEFTLGINGLPDNYDVSLVDGYNLPIRVSNNAGCPVADCPVDLGPNCPAPLKGPFDSSGFPVGCKSACLAGLGGDPANNYDCCTGSHNTAATCPSSNVDYYSYFKNNCPNAYAYAYDEASGSSLYTCPANLAADYTITFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K814</accession>
    <name>A0A4V2K814_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_495483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K814"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="163"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="552" mass="60061" checksum="6423F949C87B3B30" modified="2019-07-31" version="1">MSNPDSISHVLELVSHLDGPRISSGDIAWATDIPAGKQLLQWLGAQFPDPSFADQVALAESNHTGPGCNPSLRASLAPIALYSEELDVLAALKVQDGSPRTISGGSTPSAYELPSQLRFRTAVLEAEADLLDKQAARYKHRLSAVKAASKDTKHTIHPLRKQIQMVDDTIEGQQQRLADLSAEMDNNVARHVDSALRVMHEAVPHDVLDKYRADIALLSSSRTEATTAVKQLYRAVDDGSGSLPTVGELQDDASTIHVRLNELERDTTLFEKILQVAYAEELEKMAKRLEEAAVGSDEIVNILSSADPGSVSDEEDVPVSTLKVDVKGELERAVRMDRLALLGRQESGLDAVTDHMEKQLIPRLQDTYTDLHERSIAAVETEAIVSALIEELEDINDAVEAAKSTTSESVEDPHAILEVEMVDLLKDLLGDSPGSNTVLLDRRDVVAEVSKLSARHAALKAAYEEWTSKLRGQIQELSLSAGPLLSTVYTHAPVNTSQPFAPGPALAALQIDTCAKASELIAAAVKLQKETELNSRDQRKLGSFVEKWVQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K846</accession>
    <name>A0A4V2K846_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid permease-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_926622</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K846"/>
    <dbReference type="STRING" id="114155.A0A4V2K846"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="65"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="581" mass="63462" checksum="5095EDBE6B913AE3" modified="2019-07-31" version="1">MAALPPARTPSWNSADEAKEVIVDGLEKGSPPESLRDIKTSVWTRVFVGDASQDKETKRAMQSRHMIMIAIGGTIGTGIFLSAGSAVALAGPGSALLSYFVVGVFCYGVVISLGEMASYIPVTGSFAVFGSRFVSPALGFTLGWNYWLQWSLSIPSELTAAAVILQYWDSNITPWQWALIIIAPIFVMQLIHVRVYGESEYWFAMIKVVMIIVFIFVGLIYDWGGVRGHPGPGRSNFQNGQAFIGGFGNFAQTFVYAFYSYGGVELVTLAAGESASPHKTVPRAVRATFYRIIVFYILTILTIGLCINNADPTLLTAAYDSSVAASPLTVVFQRAGFGAAAHVVNAVLLTAVLSATNSCFYASSRMLLSLARQGHAPRIFGWVNSRGVPVPALMLSLAVSFLTFLTTIWGEGVVFSWLVNLTGISSLLVWGTIGIISLRFRAAWKAQGRPIGDLPYTQPLFPILPLVAIILALAMLIAQGYAAVVETPFDPKNIVATYIGVAVYVLCYVGWWAYEFFWLNKRQHFVPLMDVDLDTDAVWGPGEGLRLRQEEQEALEKRDAQDIADGKRSRVWARQAARFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K847</accession>
    <name>A0A4V2K847_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_926608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K847"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14644" checksum="19AE5400E4C43E92" modified="2019-07-31" version="1">MQRASMKVFAVAFCPTVSSNTIYPEPCLLKPHSRPSTPSVVPLLARDIEPPSSRMSLSRTSTYLRRWDSEVQARRHKAQTLAVCRGTFDDVVDLTNIQVPFLEIVQGKDNISVLVCRYLSMRSQPTPNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8G7</accession>
    <name>A0A4V2K8G7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_976293</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8G7"/>
    <dbReference type="STRING" id="114155.A0A4V2K8G7"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="282"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="323"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="370"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU59958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1003" mass="114133" checksum="B8AE92E02EAC1738" modified="2019-07-31" version="1">MSSPAPPPAELQANLRQRRVGDRTSSSSPATSSGEPDAPKREEVVWGKTPSGEVFRVPTTHDVLTLFHPGYPKSHIDLLNLALLGTQLVLFFTLPRNVSRAFFFLYFAFWRAAYDLGLGWVLTKQSKRKWIVREVQRLGWLDPDRKPEVRRWIKSQLAGKMGKDYSFDELPLEYNTWLLFRQLVDIILLNDFLAYCMFAFSCFRIPEGLSLTLHIMRWIGGIALIAFNLWVKTEAHQVVKDYGWYWGDVFFQRGALVFDGVFELAPHPMYSVGYAGYYGLSLIVGSYAVLFVSLAAHAAQFGFLVFFENPHIERTYGQRKPLAVRSPIQPRAPRKASEDSLESSHVRKASTSSTSSLAEAPTPAVTEGDTATESEELITEVETETEMVTPPRQLKKLRTHALSSKSSRDSLGRPASPKTRGAISQHDLFHRYFRKDAVLLHNVDMFRASDFQLILILSYAVALTICPTNSLPLHFVHALTWCLFNEFGLGLLLRAQSQNKFLVRHYLKHYHYPQNDRGQGAIREAFQNWKGIYNMSMCMSYVSLGCLAWKTYSVPDWQHWTAGNELLRHTLGALMIGLHIWSSLESYEVLGLFGWFFGDFFIEDYPAHLEYTGIYRYLNNPEVISGATFFGLALVSGSKLVFALAVIRHLSHWWFLSQVEYPHMRKLYGESIRSDAGFVKVIKTVAQKNVRLLESRAGKHAPEIKRVAREVKGTFDKVYEETAEVVEEFLSKSRPKISEVVEDTKVLLQQSRERLVISRVANDLSSYDTNKYRISIVPSADGTLRFHLGEPIRVKWRAPNHHSRKDWIGIYRVGSNQSNLVTKTSSLGMWMPVHDGEYDGDIPIELQKPKRTAGASPDFEEDEVVFTGSVLPWRTGKYEMRYHHDGKYNVMSLDGPFEIYVDKPSQLTFDTVRGTLKRIVPLCLDSDPSLIPQSCKGYSAQAEAEDGRDPDDFRFWTERQAKRISLAIEQAFDVELTPDVIVADANLSALANRILTSKELLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8I9</accession>
    <name>A0A4V2K8I9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_923056</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8I9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="448"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="511" mass="57602" checksum="552073B57B2C41D6" modified="2019-07-31" version="1">MDQAQSQSWAFVCVGILIGIVLFRWNINPLNNIPTAGRFSSSNWLSYLAAFSFIRRGRETLQEGYRQYYGSAFKVALLDRWMVIISGPKMIEDIRRRPEDELSFTETVQTLLQYKYTVGQKMQDDPYHVVVVKEKLQNRLLPNVMPSLIEEVPPTVQKYLPVTDHEWTSVDVLAAALKVVARTSNRVFVGSSLCLNEEYNDISVQFAVEIVKAGTVLFLFPDILKPIAAPIVSKVRRTTERALRHLRPIIQERRTAMQELGTDWSDKPDDVLQWIMDKAVAKQESDADIVERLLLLNLAAIHTSSSSIAHVLYHLAEQPELLGPLREEIESSIDAEGWTMSSFARMWKLDSLLRESQRYNGFTLASMMRIAMKDIVLANGMFIPKGTLLGAAAHPTHYDNGHLANAEIFDPFRFARLREANNSEGSARLQFASTSPEYIAFGHGQLACPGRHFAASQLKAVLSYIILNYDFKLTDTESCCPRPQRPPNVYVSLAVLPPIGGTIQLTKRAVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8S2</accession>
    <name>A0A4V2K8S2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_921521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8S2"/>
    <dbReference type="STRING" id="114155.A0A4V2K8S2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="120"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU61118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="38176" checksum="28DD7639BBE4A75F" modified="2019-07-31" version="1">MERPQVSGIPFPIQPRRAFSAQDRSGLLEPVAQATRTQQRPHSSVNAGRDEDDYDDDWTMLDEDCYRLTPEEYRNRPLPPIPLEARMRQAIHRLKVEPRLGSRSPTKAMSRFTEGLSRRLAKECVTCMERIDGAEIRTPCGHYYDEQCIDQLFDAASKDEALFPPTCCGKRIPLASVRDTLSPTTLASFEEKRREFGSQRRVYCAKASCSRFLSVQYDSTRLTMNAPRLRCPDPECGTVTCMRCKLEVKEGVHHRCDKDVEDVNALELGERSGWARCPGCETMIELNQGCYHMTCRCKMEFCYLCKKQWKTCSCPQWEDIEQTNDNGGEGIASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8U7</accession>
    <name>A0A4V2K8U7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8U7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="221" mass="23922" checksum="CF43C0F9114C6799" modified="2019-07-31" version="1">MPTSCSPELYVACPTMINVHEWLMIHHTIITSKGCPGGKYDVFAVAEFPIFAAKAECISTSIGIPLGPVTVEFSTKLDIRQNCTTHLDLVTANIKYPLLASVEGGAFKGDLHCDCGIDMSIGVPEIYGSVRLWIDSGDHCRTNASLWIDFDLTVFDVAYKGKFAVLPIPRWFISVANSNKLLEAPAEKISPPPSPSISVNNKTNNVTNIVTPPAVDFPVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K921</accession>
    <name>A0A4V2K921_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_945891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K921"/>
    <dbReference type="STRING" id="114155.A0A4V2K921"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="286" mass="32292" checksum="F7BFC0954B4C0100" modified="2019-07-31" version="1">MTSCPWNIYAEQLFPLGYGHPLWYPEPVGGREILIGDVGWFRTNGQFTPLFNVKSSREDPVNQQNGVPRGFTVFDSPGSRTVFTNPNAIMQRSLCSRTVQTREVEAELSAGSFAFQTTADCGALVLLEPPAESADIESKRHIVNYMRRHFDSWLDFVNGQEGMGLGLEEQDNVFVSGTMKTTHWGFAAFQGNGSERKEGRIIAQFTPYATASLSVSLANASMPRSHYRYGPHPAQEVSVPRNQCLFIHYYKMRRRRPLPKFAMRAAAGPHDLGIPMLRWRWPLTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9E2</accession>
    <name>A0A4V2K9E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Pleiotropic drug resistance ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_808418</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4V2K9E2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="662"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="692"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1220"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1253"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1335"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1362"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1485"/>
            <end position="1508"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="186"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="890"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="845"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU63508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1518" mass="168666" checksum="A3114106B7C008BE" modified="2019-07-31" version="1">MAADQARLDPVQLEDIEGHDRVPELLGTTHIAAAYGNAAYHNHIHPHPSSDDVPSETSHPEYHGAPLTRQQSTSSHVSIDRFDPEGVAQLRRTLSRQSQTHAEPHIDSEKPSRGFGTQQSTNSVLTEDTLASPDGPFDFEKTLRGLLRKIDDSDIKRRELGVAFKDLRVVGVGAASSYQSTFGSTVNPLNAIRELRDALHPATRDILSGFEGVVRPGEMLLVLGRPGAGCSTLLKTLANERDEFHGVHGSVWYDSLTPEEIEKSYRGDVQYCPEDDVHFATLTVDQTLRFAATTRTPHTRFDNLPREEHVAHIVETIETVFGLRHVKNTLVGDASIRGVSGGEKKRVSIGEALVARSLLNSWDNSTRGLDASTALEFVEALRIATDVFRQSTIVAIYQAGEQLYEHFDKVCVVYEGRQVYMGPANQARQYFIDMGFEPANRQTTADFLVAVTDPNGRIVREGYEHRVPRTADEFAEHFRKSQLGRGNSEDVDAYVAEYTGKPERVAHYKSSAKLEYARHTRPGSPYIASIPMQARALMRRRVQILGGGIAAQVVQIVSFVLQAVIVGTTFLRLKANTSAYFSRGGVLFFSLMFAALSTMAEIPALFAQRPIVHRQSRAAMYHPFVEGLALTLVDVPITFVTQSVFAIVLYFLVGLQQQADKFFIFLLFTFAATITMKGWFRMIAAAFKSPAPATTVAGFSTFILVLYTGYSLPQPYMIGALKWITWINPIHYGFEGLITNEFHGLDGTCANLVPQGPGYENVALANQVCTTVGSTPGSLIVRGDAYVQASFDYSYSHIWRNFGIICAFGLFFICVLLYLYEVNQTLEGQSTVTLFKRGSKSDVVRAAEQDTASDEEKGRGRGAPAHPDEADNGLHGADLKDAMPEVHETFSFHHLNYTVPVGGGKTRQLLDDVSGYAPPGRLTALMGESGAGKTTLLNVLAERTTSGVVTGNRYMNGHPLPPDFQAHTGYCQQMDTHLPSATVREALLFSAQLRQPPEVPLEEKKAYVEKVLGLCGLAAYGDAIVGSLGVEHRKRTTIAVELVAKPSLIFLDEPTSGLDSQSAWAIVSFLRDLADSGQAIICTIHQPSAELFQVFDRLLLLRKGGQTVYFGDIGPRSTTMIEYFERNGARKCSDTENPAEYILEAIGAGATATTDVDWYDTWLKSPESEKVQAELERIHTEGRQKPPVQARLKKEYPTAWTYQLALLLKRNGEAYWRDPVYLIAKLALNVGSALLIGFTFFKAKTTIQGSQNHLFSIFMSLILSVPLSNQLQVPFIDIRKIYEVREQHSRMYSWTALVTSQILIEVPWNMLGSSLYFLCWYWTVGFPTDRAGFTYLFMGVIFPLYYTTIGQAVAAMAPSAEIAALLFSFLFSFVLTFNGVLQPFRLLGWWKWMYHLSPFTYLVEGLLGQALGHLPIHCSDIELVQITPPSGQTCQQYMGPYISANGGYITNPNATDSCSFCQFDSTDGFLEGNFNVYYSHHWRNLGIFLAFICFNVFAIYLFTFIFRIRKGAIFTRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9W9</accession>
    <name>A0A4V2K9W9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-related protein 2/3 complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_864183</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
            <location evidence="7">Cytoskeleton</location>
            <location evidence="7">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9W9"/>
    <dbReference type="STRING" id="114155.A0A4V2K9W9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU65488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="410" mass="44030" checksum="15563EF6D3F158F6" modified="2019-07-31" version="1">MAPIEVVSLSQQSPVTCHAFNADRSQIAVSLNSNEVRIYARQGNDWNHIDTLSEHDKPITSIDWAPKSNRIVTSAQDRNAYVWQQTPDPQTGNVIWKPTLVLLRVNRAATFVRWSPNEDKFAVASGARAIAICSFDPEGDWWVSRLLKKPIRSTVLSVDWHPNNVLLAAGSADMKARVFSAYIKDVDKRPAPSVWGEKLPFNTICGEYASPSGGWVHSVGFSPSGDVLAFASHDSTINIVYPGGPAIYTIKLAILPLVTLTWATEETIVAAGHDCQPLVFGGNQGGWELNGSLDDVHSNKSSGGSRSGFGGASPVGRLNSAAFNTFRNAAERGISNVPGSPTTSSSTESEVFTVHQNTITSVRPYAGVPRQITQVSTSGVDGKLVVWDVNAVTPISATGLAGKLGKLQVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWT8</accession>
    <name>A0A4V6MWT8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_948065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWT8"/>
    <dbReference type="STRING" id="114155.A0A4V6MWT8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF105">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1-ALPHA INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="172"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="349" mass="39400" checksum="3C504BF28527BE1F" modified="2019-07-31" version="1">MIRAPFRLQTSQLARRPAVATSQVSKQRYWETSSDKQNTVQGPSAVHPLPLPPDTPILLLKTKPVPDAPTWLTSAPDKFLEYLRSPNAAPVIIRARKDKDDHLAETLLCTLRAAPSERLVEVETGKWDRKHGWDDRISCQLGVFLDWLTDQRKLSANEEQRMLYLAQWRAHEDVPGLQDVVKPPGLIVPLLQQEKADLYQSAFFVGPVGVVSALHTDPYHNLYNLFSSSEPSLFGKHFVLLPPSMSPFLERKDSEFMRNTSHVECFLKATSSDTFDVAINPDMVPAKAARAMLASDSVLSCMLQEGDTIFVPRRWWHRVENVMAPSAARHGKKRGWTAGVGWWFLPRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWZ6</accession>
    <name>A0A4V6MWZ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_301037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWZ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13839" checksum="0F0A24BAC4796AD9" modified="2019-07-31" version="1">MNFSVHLLRCPSALFSSSVAGSGAPTCRTCRCLFGSILLARRDRFSSSLQSQISQPLLRPLPPAFPCYPTSDPSGDCTDVHRLWSVASFRANESGAMQGANFETFVLTNSTLSACFNSNVAWRALRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MDM0</accession>
    <name>A0A4Q9MDM0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_823695</name>
        <name evidence="2" type="ORF">BD311DRAFT_672516</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143487">
        <property type="protein sequence ID" value="TBU24112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MDM0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU24112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="73" mass="7929" checksum="F9B065A2EDCFE021" modified="2019-07-31" version="1">MFPAQASHRRQRRDENAPPRSLTPALPPLVHGSLRRVLRPTNGPLEARVEGPAPAPVVAQPPPAPVYPWASDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MV34</accession>
    <name>A0A4Q9MV34_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IMS import disulfide relay-system CHCH-CHCH-like Cx9C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_806902</name>
        <name evidence="1" type="ORF">BD311DRAFT_656393</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MV34"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034595">
        <property type="entry name" value="NDUFAF8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34561:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU31565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="8726" checksum="9A34FA6A357CE695" modified="2019-07-31" version="1">MTQVTKTTTTPLRRLALHSTTTCSAAASAYGKCILATYTDVQKDSCKEAFDKFGQCMREAVSFVRSLACTSPHTFHVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MXP5</accession>
    <name>A0A4Q9MXP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_948801</name>
        <name evidence="10" type="ORF">BD311DRAFT_656947</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143399">
        <property type="protein sequence ID" value="TBU31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145126">
        <property type="protein sequence ID" value="TBU58281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MXP5"/>
    <dbReference type="STRING" id="114155.A0A4Q9MXP5"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16458">
        <property type="entry name" value="RING-H2_Dmap-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000044">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042823">
        <property type="entry name" value="Dma1/Dma2_RING-H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067:SF7">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15067">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17123">
        <property type="entry name" value="zf-RING_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="78"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="228"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="309"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="396"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU31522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU58281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="454" mass="48301" checksum="B240B57BD0307637" modified="2019-07-31" version="1">MLRRRRSAGTLAATNTSQIPAVAVARTVTGPAASGSSSALHAGTGPSHRIRLVPHLDSRRSLRFDPISRDVREGDPPLRIGRFTDRSGIGIAAANATSQNKLAFKSKVVSRAHAEIWCETGGKFFIRDTKSSSGTFLNHVRLSPANNESRPHELKDGDLLQLGVDYQGGTEDIYKCVKIKIEVGREWQNHSNPFNANALKQLKSIAIPQAPATNTGKKVAVKSTLPDCCICLFSVTIHQALFIAPCSHAFHYKCIRPLLEAHHPAFSCPLCRTFADLEEDVEVEIDPELDSKSMVDGAASIVGIAVSAVGDRPNTGDGSSRERERDRDVGAETEVELDTGASRLGSSLRARRAAPAMPNGGHLRGDDMAEDVDAEMEDVIALPPLPESQSVLAVEQIYGDGDRMDVRENSGSPVPGPARASPGGSSEGDAEGESGASDGSGLVGDAGVHGKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NE02</accession>
    <name>A0A4Q9NE02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_349254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NE02"/>
    <dbReference type="STRING" id="114155.A0A4Q9NE02"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="543" mass="60012" checksum="C2826FEDF3EDDA1C" modified="2019-07-31" version="1">MTIVLTPVWSNGVQKLKVTSAPPAKLAHGLTPPMLDDAVHAQRCLAQLRSKDKNIEKYIYLSQLKDADPNMFYRLCLTNMAEFTPLIYTPTVGDACIQYSHIYRRPEGLFISIKDKGRIGQILRNWPRKNEARISVVTDGSRILGLGDLGVNGMPISIGKLSLYVAGAGIRPESTIPICLDLGTDTQRYLDDPLYLGLRQKRVPMAVMDEFMDEFMGEMAKAFPKLLIQFEDFATDKAFAYLDRFRDRYPLFNDDIQGTGAVVLSGFINAAKLSSAASGRPLSDHRILFLGAGSAGVGVAMQLQSFFMLQGLSKEEARSRIYLVDSQGLVFDGRGPMAEHKKYFSRKDYNGPALTNLTEIIKFIKPTALMGLSTTKGAFNQSVIEAMSALNPRPIIFPLSNPVRLSECEFHEAVEWSKGNVLFASGSPFPEQDYNGRTLYPGQGNNMYIFPGLGLGAILSRASAVTDSMVEASSLGLAESLTPDERADDLLYPRIERIREISADIALAVIRAAQKAGVDRSADLRRKSDAELLAFVKERMWNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFH6</accession>
    <name>A0A4Q9NFH6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_833428</name>
        <name evidence="12" type="ORF">BD311DRAFT_759557</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="ML143427">
        <property type="protein sequence ID" value="TBU27911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145280">
        <property type="protein sequence ID" value="TBU51863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFH6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NFH6"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU27911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU51863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="212" mass="24890" checksum="B6E2ADA9DC78AFB0" modified="2019-07-31" version="1">MNLFRLFGDLSHLASIIILLQKIRSTRSCRGISFKTQALYATVFITRYLDLFYDWVSLYNFTMKVFFIASSCYILYLMRYKYRPTHDPSIDTFRVEYLLGPSAVLALLFHYRFTVPEVFWSFSIFLEAVAILPQLFMLQRTGEAETITTHYLAALGAYRALYIPNWIYRYFTEDMVDPIAVTAGIVQTALYLDFFYVYFTKVLQGQKFELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NH58</accession>
    <name>A0A4Q9NH58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_845536</name>
        <name evidence="2" type="ORF">BD311DRAFT_690672</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NH58"/>
    <dbReference type="OrthoDB" id="2753746at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597605" evidence="1">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="131" mass="13870" checksum="84B02E543D62661E" modified="2019-07-31" version="1">MHFSALSFAAAAIATASLATATPLKARADQTIVSPLSDDPIGPSIEFQFADESHTAGSTSFVRTTLRNSTFSALIGDNIPFESARPDFISTSLPVPAEFVKGFYDLVVEEVDGDGSVIFTGESTDLAYLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHM1</accession>
    <name>A0A4Q9NHM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_915484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OMA" id="WLENAPC"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="C:TRC complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PduO/GlcC-like"/>
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        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HbpS-like"/>
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    </dbReference>
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            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="287" mass="30996" checksum="C6C8EF922DCCBA16" modified="2019-07-31" version="1">MAYAGLGALQMFNGFNGNQPMPPSEAELATQALNEESLYRFPSFDSDAAVMLGLSLRKRFRSSSRHVKVRGMVISIQTIAGHTLFSCTVGNLGGLDGAGDVSLDSWACLEGMISVVRRTGHSSYYVEKGMNAMGKSQKQLGVQPDLKICGGAFPIWLENAPCCPIAVVACYSGSSQDDHHLVVTSVRDYLKKLVRDNPPPPAPSTMATSMGTSMGTSMGTSALGQSIPTIMSTSMAHQHTGHTHAHSHTGRPPSTEWVRDPASRGIQHLHDEHDEYHDHSGELEYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMS5</accession>
    <name>A0A4Q9NMS5_9APHY</name>
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        <submittedName>
            <fullName evidence="7">PLP-dependent transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_870848</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
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            <name>pyridoxal 5'-phosphate</name>
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        </cofactor>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="KYNURENINE_ALPHA-AMINOADIPATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
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    </dbReference>
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        <location>
            <begin position="109"/>
            <end position="453"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU62725.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="466" mass="52141" checksum="C5E1E90B651C2557" modified="2019-07-31" version="1">MADDFHAPNGLSQNEVQHPEQSPISSRVLPSSFYESFISDSSKRRIEDPIRVLLPLEDRPGVISLLAGKPNADTFPITSLQFTLRDPVTNDEVPVSLTEAELSRSLQYSGSKGIPGFLEWLIGLQEYSHGRKRGEGWDLAFGTGSSDLIYKAVNALVNPGDVVLIEAPVYAGVIPMFHSAGGEMMEVQTDQYGIDAQGLRETLDSWPRDKPKPKVLYTVPYGCNPTGVTSTVERRLEVLELARKHNFLILEDDPYYYLYFGSAPRPPSYFTLERDQPEVGRVVRFDSLSKVLSSGMRIGFISAPQPIIDAVVMHTMNSNLQPPSFTQVLSLRMLQVWGYEKLRAHVDRVAEFYRAKRDVFERQMRKHLDGLAEWNVPEAGMFFWFKLQLGKTGAASGLDEGDSEAVIRTKALENGVLALPGTVFLPSGRKTTYVRASFSLLPEDQVDEALRRLRETILKAREDVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNN9</accession>
    <name>A0A4Q9NNN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_980709</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNN9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="10689" checksum="F9A46B5B63BE1F5A" modified="2019-07-31" version="1">MSDYTDVQDDIFDANWDELMNQCSAAMLALFVYDFLITFDDEVNLFWLPRRLNGPSILFLLNRYLAQTVQIYGWMPMPTTSEGYDRFDWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQ64</accession>
    <name>A0A4Q9NQ64_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_973865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQ64"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <end position="333"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="847"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1003"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1029" mass="109313" checksum="259A086C8C279A99" modified="2019-07-31" version="1">MSIQCPSYISARSAEVILSDVRPIKLKPDALHSINVLLDETLYSILTTARSLATDRLKAALLKVLPTSLGKEALLEAEVELKAYWDRTGSARPLPSGRNGDSKEFDLQWSFELLRLKCEAYSTMNDSDEDAEAEKRLQQRMEQAGSSSPPSPALLSPAALYLTAILEAICEHVLSNVSRVAARDSSRTLATVQDLFTALGEDDTIFGMFKAMKVYAHIEGLSRAQAQRPRRSKSFSRSTDQKNAAPRTSTSSPLNGESVATNGTTTASAIAPGGSSRMSTDSQKSTTVVGSSESRRTSMEKVKGAKIFHSRTPSDKQHARDDSASAALARSASENGINREHGPEFEASEDEELQQEFDELMRSGATMKVSLTPDRLKSMEVYKQERFERERLSRRGTQSADNIQDGSLPLPEPRPRTTTGRSSIRHVDSIVEDEEEHSSSSNHAAVASPTSLQSNAASASARMRNTSFTATSAGSRPPSDQRLRSISISNVPHPRDKDGITRRVSNSNGTSRAGGRTGSQNAAPPPPSAGMPKRTRKKQVNRESMDLDEIMAGSDGEDVDVEEVRPPASLPASPRTPGGSRPHISKAAQDLIAFLEEGPPEEPSYSSSVNASVISFESTKTRSGRLQRMMSRLTLGGSRESLNGSISEEQPKTPRSLSRKGSKMGMVTSPPPSYKGGSLQSKRSIPNVSVYPNVIVATPPPRLPLQNSQTSSSLASPPVSATSSLHTSNEDVAFSSQHSSLSRRTTRKAVPPLDDVVSLSSTVGESVFEGRPAVNGNRRAQVDDQGKDGTSSPIPPVVRRSVVLNGHPVKLDTSEPSLHPRAASITSPTSTSDRKSIHGKSESGYASRSTSRSPITPSERLPPPPPPAPTIPPADAENLRRLLEAATSADECRLLVDLFLVKNGFALKESVASSPAADTAGLAVGTGKLEDALALAAREAQEVERGLVALFLGGGGQVDLSGAPSLLPSLQNAEPGSGSGPSDAAGSASELGSKSGSGSAGQSNQPEPVAAGFQQQQQQFRASPVAVSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQQ2</accession>
    <name>A0A4Q9NQQ2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caspase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_815485</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQQ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="289" mass="32947" checksum="B424358B310CE56B" modified="2019-07-31" version="1">MPIATNQEPEGDKKALLVGIRYETNRNLAENGFKLQDNTRKDVENLKELLMSTYHYTEKDIVIMTDSDTVSHESKYWPTRANIIKAMNTLVEGRRPNDQIVFAFSGHGGQVDVGVDKREDDGKDEILIPIDCEVIRFDQDEAPVYSNFIRDDEIRQILVDKLPQGVHCTMIFDCCHSGTASDLDNVEVLSPISPPGSQTTGGFDKQQTFGRKTGGIFMEITWGSRHHYNNKDLMREIRNQIKAVTSKANERLKKKHEGQVDFTDYFVTPRPQLGSLTKPEDILHDRFML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSS2</accession>
    <name>A0A4Q9NSS2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_453050</name>
        <name evidence="1" type="ORF">BD311DRAFT_125962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143527">
        <property type="protein sequence ID" value="TBU22764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSS2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU22764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="160" mass="17747" checksum="EAB3B17DE5E0C177" modified="2019-07-31" version="1">MICAASEMACIPFVRSPSLAFRGWHCSHAENMSGLGILQSSASMSCVKISFDGRRLETSPLPVRLPFDSRVLTDLRLGRNYQGQPLSRSDLHTMSLGWHPRSGMFEKHAAHGSQPIEIVYAVKMLHTGTPSTQRPPYLPSYRRRCLKLQGSVIASILLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NU51</accession>
    <name>A0A4Q9NU51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NU51"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="102" mass="11833" checksum="CE4F8D6771CDDA00" modified="2019-07-31" version="1">MPRCQQSWWALVSSPPVHPEARGQVHAGWFSRVLGRQWVSARAPAAGWWNSGELLGCIKCQWDNSRSMLRHQGGVLLMEKHGQRSRHRRECFRSARRRTSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVQ9</accession>
    <name>A0A4Q9NVQ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_827129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVQ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="15536" checksum="C1AD143F401A6454" modified="2019-07-31" version="1">MNRCIAHPLCTNSAAASEDVPTYARERFGNQKVISSGLGLVRSSYGPKANAEAEARPTRYRTRSLVPLTSTQCERRRICPVSSRRIPRRIRLPSTSISMYTYIYTTALIRLMIRLGHSMATSGSTSQSSRTTSSACSRSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWT6</accession>
    <name>A0A4Q9NWT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_829570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145207">
        <property type="protein sequence ID" value="TBU53701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWT6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NWT6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33796" checksum="269738C0852F31C9" modified="2019-07-31" version="1">MTLPTRDSSPSTSRTRSCMLDGDNPGLTLETSDGVLFQSCAVLFYLASPVLASQLSSTSSSRPRRLLVPETSTVISIILKIYHPVDEPPSTDIVGIYHALMAAEKYRMQKAVQYLRNALLSKKDDPSTDPVLLYAIGCRCGMRDLAASAAKRTLRMEHESSTSTYAPLDDLGVPASYLHRLLTYQQECREAARCVAEGKWRTQLESACGLGEWADDGKTPCWYGPYMAAIAMQRWPTATSVTAPDLLRGVISSCRSRKDGGGRRRGACSYCSNPEKILLFYDFTKYVAETIEAHVDKVVLTWPESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P082</accession>
    <name>A0A4Q9P082_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_1033651</name>
        <name evidence="14" type="ORF">BD311DRAFT_743934</name>
    </gene>
    <organism evidence="14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P082"/>
    <dbReference type="STRING" id="114155.A0A4Q9P082"/>
    <dbReference type="OMA" id="MIFGFDP"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU35412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU65252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="214" mass="24152" checksum="02FA1F26C7267686" modified="2019-07-31" version="1">MSTCNIRPLSRTLPTSTRPKLVSSIRTRFHTPASCRGKATKAPSSKGAATGTSQVSQVEKETLPWQEYLAIRKRKRRWETAVTIPTTVAGFVGGISYFGNLEMDPNKPIFNVDPMFVYGAATLGCAGLGYLIGPVIGSSIWRLTHRRLMRLIEKRDKEFHQHIVKNRVDPTRQSATNPVPDYYGEKIGSLHDYRQWLRDQAKFRRKAASFLAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P2X5</accession>
    <name>A0A4Q9P2X5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_536891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P2X5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P2X5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="246" mass="26792" checksum="A1D2BD3604296E92" modified="2019-07-31" version="1">MSLDHNPAVSPDLLLYEDAVRNGLRTRAELVLANLKEEGVLDDELSAEGGRTTLGCAIILYRAAIESTTNPPAISLPSTTGRQSITLSQESCPRALRTFISVWSQITPAIIALSSEHLEDVRRLLFGMHPLSTTCDPHLEAIVRMLEMVAFVLGTWCMRRDPPAGSHASAPIGSPAPEVDASGCKDEPSSMPRTKRQLRKSENASPSTDRPSKHPRKDPAFRQAILANGKTDDPREIPLEASMPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P3R1</accession>
    <name>A0A4Q9P3R1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7330 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_630868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P3R1"/>
    <dbReference type="STRING" id="114155.A0A4Q9P3R1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055754">
        <property type="entry name" value="DUF7330"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24016">
        <property type="entry name" value="DUF7330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7330" evidence="1">
        <location>
            <begin position="282"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="467" mass="51626" checksum="89E5E23F56902E6F" modified="2019-07-31" version="1">MNPPAAGYSATYPEEKGPEMRGLLTPPPVGPPGYAAVYQPSSTYVNPQERPRNARRRRFWHFLACTVLFFVALHLLLHQRPFKKGLGPLPWSEISPGTTEPEAQWSPSICEDNVNWKDDSDRAPTHGYHYRAHTTLTLPVSAEELSFIAEGANAYGTFDVSQDAHTDSENAVVDIEVEYRVSDALDDATVCRTHAGQGKWGLGIFTPRWSHPHNERQLRFFVHVHLPSSDKLNIKRFFTDLPIFRHHLAELADTVHFEEVSLRSSNSPIDVDSLAADRVRATTSNTAIRGKFNTSTTLELQTLNAPIVAEATLVNGRGEQPTRLILKTSNAHIDSSVHLQSSTSSATGGKYDVSARTSNGPIDVSIIDAPVGHTLTLDAHTSNVGAHVALPKTFEGSFDLQSSRWFRPTVEWDQDVEDPAGKRRTRHVELHTINGGSVRGNAWWEEGRKNEGTVTVATSNAAVRLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7M4</accession>
    <name>A0A4Q9P7M4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">laccase</fullName>
            <ecNumber evidence="5">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_928381</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the multicopper oxidase family.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="5"/>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7M4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13856">
        <property type="entry name" value="CuRO_1_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13882">
        <property type="entry name" value="CuRO_2_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13903">
        <property type="entry name" value="CuRO_3_Tv-LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000045">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000125">
        <property type="entry name" value="Laccase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000112">
        <property type="entry name" value="Laccase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF394">
        <property type="entry name" value="FI03373P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0186">Copper</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU57803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="522" mass="56125" checksum="AEC70A667A877D65" modified="2019-07-31" version="1">MMRKFQSFAALVALSLSYTHPVAGAIGPVADMTVTDDNISPDGYSRAAVLVNGVFPSPLITGNKGDNFQLNVIDNLTNDTMLTATTIHWHGFFQKGTNYADGPAFVNQCPISKGNSFLYDFTATDQAGTFWYHSHLSTQYCDGLRGAFVVYDPNDPHASLYDVDDESTVITLADWYHTAARLGPRFPLGADTVLINGIGRFTGGDAVDLAVISVTQGKRYRFRLVSISCDPNFTFSIDNHNLTIIEVDGVNHQPLTVDEIQIFAGQRYSFVLTADQAIDNYWIRALPQIGTVSFDGGVNSAILRYDGAAAIEPTTNQTGGSNPLVEANLVPLDNLAAPGSAVVGGVDWAHSFDFSFNGTEFFIDGTPFVSPSVPVLLQILSGAQSASDLLPSGSVFSLPSNSTIELSFPLTATNAPGGPHPFHLHGHTFYVVQSAGQTEPNYVNPPQRDVVSTGTAGDNVTIRFTTNNPGPWFLHCHIDFHLEAGFAVVLAEDIPDVSSANTPTTAWENLCPTYSQVYPSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P8D7</accession>
    <name>A0A4Q9P8D7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_912033</name>
        <name evidence="6" type="ORF">BD311DRAFT_744847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably involved in translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P8D7"/>
    <dbReference type="STRING" id="114155.A0A4Q9P8D7"/>
    <dbReference type="OMA" id="VENHIHI"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU35920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="113" mass="12635" checksum="176D27DFB4C22D29" modified="2019-07-31" version="1">MSVQNLNTFDPFADEGDPLGSTQDVGSQANYIHIRIQQRNGRKTLTTLQGLPKEYDLKKLLKAFKKEFACNGTLVEDEEAGQVIQLQGDQRLKISTFLVQEGIPKSTIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9B8</accession>
    <name>A0A4Q9P9B8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_915125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9B8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9B8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF392">
        <property type="entry name" value="HAP41P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043780936" evidence="8">
        <location>
            <begin position="23"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="411"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU63979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="633" mass="67079" checksum="C2293DB963E7A06C" modified="2019-07-31" version="1">MVPQSRLLIAASSLLFPLLTRSMPAPWDVRPANLRHGGEDLRLVVATQTETVIVSRTHNVARAAATDESEVILFLPPNAAHASLTSPSFSSSSATTRAPTSPIISSADPVAIPTSSVSVAPPPVDANLGASNNTSTNASASQPSSTGPVATPTASSDAGHVPLVMAYYPDWAGRDYPPEKIDFGRFDWIDFAFAVPDQNMNLGWDGSDDAPDLLRRVVARAHESGKHAKLSVGGWTGSKSFSSAVGTPENRATLANNILTLYQQYGLDGIDLDWEYPGQSGNSGNGVSPADSANFLEFLRVLRDTLPPGAKITAATQTVPFAGADGSPLRDVSDFARVLDWVLIMNYDSWGSSDQPGPNAPLSDACSNSTQPGASALAALRAWTAAGFPASQLVLGVPSYGYLSRSSATRLRTRAGGTRASPRVYRSGRLAENGRRRREQRQGQGQKRSMQRFVWDWIDSLLGPPVYDTDKSGLLVNEDGGTDDGQVQFRELVRQGALAPYSSSPGAPAITTNSSSAPASADGTPQSATPAYDGTFGGEDAALLRAAIEDREPRSLFAGAHGFVREWDGCSSTPFLRAGDARQVVAYDDPVSLEMKGQLVRQARMLGVNMFDVTGDTDGWDLTDALRRGLGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDH0</accession>
    <name>A0A4Q9PDH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_367301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145346">
        <property type="protein sequence ID" value="TBU51287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDH0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="236" mass="26129" checksum="B527BEAEB449058A" modified="2019-07-31" version="1">MLLRIQPLLGAITACGLNELASCNIVLDAGENLSLPLRLVRRQASHYGPHHIDVAIQMGAVPVPPRRSTHRSPSLPSMAVLPRSTFDGRVNRIWSDPLEHSDYGLMRLHQSISLTLLGVDRKALNLQDYSIRLDAPNPNNLDMHSLTMSTSSSLFTSSVCRQAKRRGASVYCWPLASTWSHRVRRRLAHMRERTRTVCCGMARPPSGERQALGLDTRRANVALTTPSGVPLTLCLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDM9</accession>
    <name>A0A4Q9PDM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone-lysine N-methyltransferase, H3 lysine-79 specific</fullName>
            <ecNumber evidence="2 11">2.1.1.360</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 11">Histone H3-K79 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_835133</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(79)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60328"/>
            <dbReference type="Rhea" id="RHEA-COMP:15549"/>
            <dbReference type="Rhea" id="RHEA-COMP:15552"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.360"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="11">In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.360" evidence="2 11"/>
    <dbReference type="EMBL" id="ML145378">
        <property type="protein sequence ID" value="TBU51152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDM9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDM9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140956">
        <property type="term" value="F:histone H3K79 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025789">
        <property type="entry name" value="DOT1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030445">
        <property type="entry name" value="H3-K79_meTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451">
        <property type="entry name" value="HISTONE H3 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21451:SF0">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE, H3 LYSINE-79 SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08123">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51569">
        <property type="entry name" value="DOT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 11 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DOT1" evidence="13">
        <location>
            <begin position="127"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU271113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU51152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="378" mass="41554" checksum="5CC403623D26ABD4" modified="2019-07-31" version="1" fragment="single">MLTIIRVDFKNPDDPDDTSFEPHPTDYPVVYLEYPNNDAQESFVLLAPKDKDHYNPIMCLESTLHTIIAHYLTPAQAALFGTLPDKDVTDDDEDDADDIPERSKSVSPYPVSEAPSPPSSEVSVASSDASYLSISSQSSFSDSSISSASSLSSVCALSSYARKDSPDSEPHVDYLRLLQRAIKKRDGPMFMKVMSAINALLSLLKYPPLPLDPFDAPAANHLGVTVRGWQRIPTNVVHRIADETYQRAVGPHIDVLKRYEAFSSEVYGELMPTFVSDVIRATGLHGGSLFLDMGSGVGNVVMQASLETGCRSYGIEIMPGPAQIARSQLEQFKTRCRMWGVRMGEVELEEGDMLKSAKVDELVKSADVVLVNNKVFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDQ7</accession>
    <name>A0A4Q9PDQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">N-benzyl-3-pyrrolidinol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_952388</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145229">
        <property type="protein sequence ID" value="TBU53000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDQ7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDQ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08254">
        <property type="entry name" value="hydroxyacyl_CoA_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="12"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU53000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="351" mass="37250" checksum="DEE76E1642CC8870" modified="2019-07-31" version="1">MTTMRAAVFHNGLTSLVLQEIPIPRPGPKQVLLKVAAAGVCHSDTLLLSDTLNDPRKYVFGHENAGYAVELGKDVENIEIGKLYAIWDIVAHGPHQIPGLPPFADSIGIGENGGFAEFIVADASDLVPVPADLRPEVAALAADSLITVYNAVHNRAGLRPGTKQRVLIYGVGGLGHQAVQLAKSYGATVFACDIKASARELALSLGAEQAFQPTELTSLTSSTDESKNFQVDIVIDFVSNQQSFTIDQAVVKGHGNSLQETPGTIVMVGLFGDNLSFNIFELLIFRTNVLTSLYGTKDDLKASLALLAEGAVKPVVSAAPLEEVNKVLDELRAGRVTGRMVVVPGMKATKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE11</accession>
    <name>A0A4Q9PE11_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_830789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="114155.A0A4Q9PE11"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Plavaka"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <location>
            <begin position="149"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="275" mass="30705" checksum="F1C3DDB54451B631" modified="2019-07-31" version="1" fragment="single">LADTSVDYGPFANVSQFRLLDHFYGRSDTHSLDSLDDLISVIQSPGFSPTDLDNFSAKKAEHALDVWMSTSGLFSADDGWHQSSVEIPLPRTYAKYKSEAAAPKFTVPGVVHRRLLPLIKLAVQDPESHLKHIYHWLAHRRYWIPPLSRPEPESESEPEPEPEPSPSSSRSTSSQPNNPSPIRVYTDCYNSDAMLDAEAAIHKKPRAAGDPADLEYAILPLLLWSDATQLSSFGSASLWPIYLYFGSLSKYCRGRPTEFLAHHLAYIPGVSNLRD</sequence>
</entry>
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        <name evidence="8" type="ORF">BD311DRAFT_770389</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="9 10">CBS 464.89</strain>
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        </source>
    </reference>
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        <subcellularLocation>
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        </subcellularLocation>
    </comment>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    <dbReference type="PANTHER" id="PTHR12709:SF4">
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        <location>
            <begin position="78"/>
            <end position="155"/>
        </location>
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    </evidence>
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    </evidence>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU22462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU51601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="170" mass="18891" checksum="E6B1538D29D558D2" modified="2019-07-31" version="1">MFFIKELSHTIHLHPSYFGPRMLQFLESKLYSDVEGTCSGEFGYIIAVVSILDIGKGMVMPGSGQAEFVTRYRAIVFKPFKGQVVDGVVNNVNKMGFFADVGPLTVFVSHQLIHPELKFDPNSNPPSFASEDQVIEKNTRVRLKIVGTRVDATEIFAIGTIKEDHLGVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG98</accession>
    <name>A0A4Q9PG98_9APHY</name>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
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            <end position="18"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGV8</accession>
    <name>A0A4Q9PGV8_9APHY</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </feature>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14446" checksum="47ADE00A85E274DD" modified="2019-07-31" version="1">MCAVCYGTSTGSSQQMRDGVRDRGSIGGPEAAQQQPLACRCCARSPGRLARWPHHAVFGIALAVQLNGRMWISRSGDGSQRNLHSEGLRTVSGDTRLQTVVERLLRSRTHRVRRNVICGEMVVWERVMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIK0</accession>
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    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145207">
        <property type="protein sequence ID" value="TBU53706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIK0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIK0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="390" mass="42654" checksum="9A6242A8F510E3F0" modified="2019-07-31" version="1">MAAIPAHPFTYSSADVVLYSSDNVVYKVHKLILAIASDFFRDMFDLPQPTSSSDSDSSAPVTEEQVDGLPVIRMLESSKALTPLLMLCYPLEEPVLTSITEVCAVLEAAIKFDLRRASQIAKRRMRELIPSAPLRVYIIACRLGLEDEAHAAAQEIYRSKVQDQYVEKLEEISFGAYHRLLHYCSAGGDAGFGMVSFSPTKSGPKSKKDKKKADVDRSRAITFTVPVSTATPDVSTIGSPTPVLSTGDVNIVLLTSDGQRLPISGNGILYASPLLSALVARRSNIAEEVPVTEPAATMSILIRVYDPFEQPHFADMLDIHAGLIAAEKYGMRKAIDFLRTALRSQELSSLREARCAPISQETCTPASIQYISREVTFTVSWLFTATATLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJB8</accession>
    <name>A0A4Q9PJB8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ricin B lectin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_961619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145195">
        <property type="protein sequence ID" value="TBU54190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJB8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ricin B lectin" evidence="1">
        <location>
            <begin position="50"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="158" mass="17044" checksum="4C329EB1423DBF30" modified="2019-07-31" version="1">MAASIIENGVYFIQNFSTGTVINLKDGSNNTRVQTAKKLELDVATVSEELWIITRNPNKQDEYMIQNAGSGTYMDVLGGTVTNGSNIVGFKSTGDKSQGWLISRNVDNKTYVIANAVTGKHYVTLSGGDTSEGKNIQIYGGEGTSETDVGKLWLIVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKT3</accession>
    <name>A0A4Q9PKT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_980094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKT3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="371" mass="42519" checksum="489ACA4BDF5A76DB" modified="2019-07-31" version="1">MFEYYNSLPLGEEWNDPIRNTVLSSRMTSISSTVWTQLHHSFFATAQASSIQYQTGLLGDIAHATGVETVLSLNEDESTLMDHFEHSSFRRAINHNMHATHEYWKILLNDTEHPQYHKRPDFFAAYKKTSSARDIIDDIEKTWEDPFDGPETVLGLFRKRLNNYPTKFTIDGAVTVAIPAFFDNLSNAAEGTEELSEELRFFETDPGQGDRPAFGCSMQGTALCLPVLLVREQLGEGAKGEIAARQEQRIAISSAAWFLKVLGIIDFPVYGLMIDGQYAYLSQAWYSEKDECCFVMDYCIRERRFDVQLQEGQQRYIAFLKKIVEHGERLERRFQEVKPQLLERMKAAGSEGIESLWWSTTAQRRRHGLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMB7</accession>
    <name>A0A4Q9PMB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1029309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="290" mass="31477" checksum="C1475432DF70EAE0" modified="2019-07-31" version="1">MPLMPPATVVTTPRSSDGTHIYAEAVGNPRNPHVVFLHEATLCGKVFDELFQDSRLTEHLYMVRYDLRCHGRSGTVRGATGQTSSLYADDFVAVMSSFATLTCCALPSAAVVADICAHVSPPPIAGVVFVSPLPFLGTTMTQTVTPRMAQVVQTLGTSRDAVELGRAKTDFVDGLFSGPARRIPDTTKAAWLGRSISQDPESTNNAICRTHDPTKLLEAGQRGLPLMVLIGSEDALVNSLAVVRELRRHFRNLEAYSIGGSSHALFIDRKDEFIQHLLMFVGRLAVSPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMV5</accession>
    <name>A0A4Q9PMV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative isomerase YbhE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_681620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMV5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF7">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="359" mass="36755" checksum="742A525E1EDE91CB" modified="2019-07-31" version="1">MVNFTILAGGYSSAIVTYLFNSDAGALSVVGQSPTGTNPSWIALHPTNQSILYATNENTEGGLQSFVIKNDGLLTDALATVSSGGNGPAFAVPLSTGEVAGMNFGSGNGVIVPTEEDPTQFVSGAPVITFPAPPSPAVSHPHMALEVGSEVFVPDLGADTIHRLVRDGPAGNFKVQGEIEQPAGSGPRHIVVRGDQLYTIHELASTLTQQTIPADPSVPAAPLAANLSIVPPGLPAGASMAAAELLLAEASPTPGSNFTQAFLYASNRNVGAQDPRGDAIAIFALEPQLALVKHVFTGLDQIRGMQLSGGPENEYVVAAGVAGSAGTVVLRRTNGGADLEIVATNTDVPTRSSFVWLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN40</accession>
    <name>A0A4Q9PN40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_672139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN40"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="168" mass="17770" checksum="2252F62D9B6C821E" modified="2019-07-31" version="1">MSSTNDYSTPSRLPADAPPPAHHLHKSSDVLPGARGAQQQHQDAPPDYSADVTESPDAWKGKNERAFGAGTDTRNVMAGGQFDRIEEDDDDDGGERPLGVQPTAQGGVAVGGRSDLPETHASMTDKLIGKTQKVTGKITRNPEMHEKGELREAGGKAAVQGEARAPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNY2</accession>
    <name>A0A4Q9PNY2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_960528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNY2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="412" mass="43000" checksum="092546E10BF97F0B" modified="2019-07-31" version="1">MIHHRPRWIEARRFGIGPWGTGFSYYTSAFGHATSIERFSIQATQTQTAVITSVQDVTSVDTATVVATITIGGANDQVTQTMILTATRTGDALTQTDTKTKAVGSTAGVSTSRARADESHSVSPSATSAADHVPTTASVPTTAVFVTLSDDGRTVTLRGSDSTAHPAATGASGGAASRSGAMEKGDVAAIVLALALVLGLSGLLLFVWRKRRASKGREVAITQFVPPASASASSVIQVPSRRPSYRSTPIPWDASTDVAQSAAATVVSPAGASGYHGGRAVYPLEEKTRLGPSATRYRAPHSPTTFVTSPSSPSAHPLLSPLSPNPVSPPPAIHTQLTSARTDLPYAWDQPPPSSEYLPLRHSTLIPSAFVVASGSLARESYRTMVSTPPYSHGGLDVHGRPPSYSPRLAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP25</accession>
    <name>A0A4Q9PP25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_765840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP25"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6813" checksum="F51AA06350A8230A" modified="2019-07-31" version="1" fragment="single">MCYHQVQPTTFNPPQPSLLCVATTELIAAADIIIRHVPFVCSAQNKILLPVPFHPAVTELCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPC2</accession>
    <name>A0A4Q9PPC2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase family 20-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_638436</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPC2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPC2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020976279" evidence="2">
        <location>
            <begin position="24"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
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        <location>
            <begin position="117"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="964" mass="107871" checksum="4581B271508565F2" modified="2019-07-31" version="1">MSSLRHHRIIIASLFLPNTTVLGDSAPASPNESALGSFVPSTPSLLTPGTPGRQPLLPKATGPLKSIVEDLKDKSRHPTPSITPRAEAANPFSRIGSSISGPESLLDALAKLNGTKTINAGSSTSPPNGARNFQTTHHGSNAHTRVQRRSSRSSAHRAASRSLSSSRHDPGHHSIKWHFENNPHCNGGLKNAIESVGDRLRRKLWVGTLGTNTDGFRESLRRNIEWRMREERESVPVWIPDSDFASCYDEFCHQVLWPALHYAVPDAPKTKAFYESAAYKQYVAVNQRFADTIASAYVEGDIIWVNDYHLMLLPTMLRERLPNAAIGFFMHVAFPSSEIFRCLSVREPLLKGVLGADLIGFQTANYARHFRQTVSRILTAEALPKGIQLDDRFIDVGVFPMGIDVSSITAKKQDAEVTEWMKSLRQRYAGMKIIVGRDKLDVIQGVRHKIQAFEAFLDKYPEYQGKVVLIQVALQTTEENEAQGGVADVVSHLNSRFSTLTYQPVVFLHTQDLTFSQYLALLTVADAFMVTSLREGMALRAHEFVECQEQRHRPLILSEFTGSYSYSGFRSCIPINPWDKRSTAKAIHQALIMSNEEATSRWEDLHNHVVTQSAQAFVTSFLVRCLRSNIEHMQSVDPADIATFDVARVLPRYRHSQKRLLLFDFEGTIWTRDIITIARNAGATGTPEFEAPEEAIKLLNRLAEDPRNQVWLLSGLTKKMLDVVAEKAPTIGIVAENGCFIKPLPDRDGNSAWISVVANFNMTWKAACMEILQYVCPVLFRMRIDRVPESACLQFTERTPGSFVEEREASVVWRFWTQKETDEHNADWQWAHRQAAEAQNHIFDSIGERYGLRIIPGSTSFLVLPNNISRSTAVGAILQPGGPLRTQLTARAAAAWLSSEAMEADNATDFDFVLGVGKDERLMRRLNELDNAETCSTSSKGTDAKWKLDPEQVVPTLWRFADVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPG2</accession>
    <name>A0A4Q9PPG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_855393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPG2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPG2"/>
    <dbReference type="OMA" id="YFCALYS"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026820">
        <property type="entry name" value="VioB/RebD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34400:SF4">
        <property type="entry name" value="MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12902">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iminophenyl-pyruvate dimer synthase" evidence="1">
        <location>
            <begin position="24"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="381" mass="42526" checksum="6CADA8A8AFBB60B2" modified="2019-07-31" version="1">MGIFSPVEGVPTKWTKKALIEHVKTGMQVELGTLPIYFCALYSIKRDNGGWGSKARANILAVAEQEMLHLALAGNMLAALGGTQPLYDKLFIPTYPSEILFEKIEMALRPANKENLECFLKIEAPYMPPPKLEVAEDVEYSIQLLPGYNGIGEFYRELQHGIYEVSATDRDLFSSNHDKQFRGEEFFGEKMTVVVDTKTALQALETIVDQGEGSIGVPDSHYSIFVQLYQRRKEWTCIDYVNEPHTADYKGKSEVAYRLSLAVDATFCYLLQTLDRCWAEGQPAKRTQLFRNIHRLMVEILSPVAHALVEQVIDGGRHAAPCFEFYPPGSDGKPLDPKGLFEGLVAEVQRAYNAATGPEHQGTREAIGKIKFCLTGLAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPS6</accession>
    <name>A0A4Q9PPS6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_931691</name>
        <name evidence="3" type="ORF">BD311DRAFT_866589</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143441">
        <property type="protein sequence ID" value="TBU26739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPS6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPS6"/>
    <dbReference type="OrthoDB" id="2736600at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU26739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="299" mass="32912" checksum="25DEFDE0CB57440D" modified="2019-07-31" version="1">MVSPSGKVDPELGIELDRLLEDSSLEESEPGTHQAAGNVITRTWRRLLLRFAICTSLTLVALYLILSRPRESHPSGPRCYLGSVPKDVPPYEPGECFDHINWTAIDLPDSETTGLLHAHAFVDLPLNATKELSFLNLGNMTHGAFRISQNGASDANVAIGIQAYYRDPEQFSKARICRLHPAEDKWGLGIYTPDVPDSDDSYNLKLTVNVVLPGTDDNGDLLPLQYVRTYLPHYNHWLGGLVDAIYIDPESIPKYSSTSSIPSVLPSSSTSFSSPASTTSARPKHLTHPPYRCVFPDNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRM9</accession>
    <name>A0A4Q9PRM9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_572561</name>
        <name evidence="11" type="ORF">BD311DRAFT_809678</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143472">
        <property type="protein sequence ID" value="TBU24794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRM9"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="732"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU24794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU57047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="786" mass="86120" checksum="03908D86EC086DCA" modified="2019-07-31" version="1">MASNDGVEQLPQLSAAPAGSPGSSIDEKAELKGVQKRLSSDSSLDIKEKLDDKAEDPYAHDEVVYVRGEPVISSGADVSRFLVDTRDDGDPAITFRSIVIGTIFAGLGAALYQIYLFKPVQVTVSTVFLLLIIWSVGIFWAKYFPKASWVEGTRFAWLAPTLRFINPGEFRIKEHVIASLVASTAAGGSSAVNNFAVQRLYYGTNVQALTAILATFSTACFGYGLVGLLRPLTVYPSEMVYWSNLPAVNIFQSLHFDSATNHQRLKVFWSAFTGMFIWEIFPAYIFPLLNGINIICLATQHVPSAAQDVVTNLFGGTDGNEGLGFASLSLDWQYITSTFVSLPLAQQANSWIGYAVCYIAIMGIYYSDAWNSKSFPMLSTSLFDQNGTRYNQHAVFGSTFTLNQTALEEVGLPALTGSNAWANLCANLSIGGLIAHCVLFWGPYVWDSFKQAYNGTQPDPHWQIVRKNYKEVPYYWYIGLLVLSFFAGLIVVLKGETTLPWWSYIIALILGAFVAPFSNLLFARLGNGIATNQLMKMVAGAVNPGKPVANLYFSMWSHDVIATSINLAGDLKLGQYLKIPPRAMFATQVWGTILGAIVNYVVMVSVVDAQREILLDPRGTNIWSGQVPQSLNSAAVTWSLAKQLYGPHGPYIWIPLGLVFGLIPTAIQWAIAKRWPVIGGVRVESVILPVIYMYSAWMSAGTNSPIWSCIIVGLVSQLWLRRYYPGWFKKYNYIVGGAFDGGSQTMIFILSFAVFGASGVPKPFPAWAGNPAQGNVDYCNGNGALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSE6</accession>
    <name>A0A4Q9PSE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_929711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSE6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7288" checksum="8C82BEF70BA298B4" modified="2019-07-31" version="1" fragment="single">MQTIHLAGITHRDVHPGNIGSTNMSDGIGDLIVENEYLGGIFFKPVFDDLEALAYSLLAFRLMASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTG8</accession>
    <name>A0A4Q9PTG8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_534624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTG8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTG8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="61887" checksum="C32D942F87BAB5B8" modified="2019-07-31" version="1">MSVPRGTTSALPNPHRALSCYDILSMIFDHFEREDPWYDHDTSIGDANSWFARQADALRKSTLGRCARVCKAFSHPALAILWRNIDNLSPFLSVAQSSLRSIPGSALQVVHLAEAGTRVSHYARHIRAVYGLGTTLQASAQNLSLLQTGTASAPLLPQLQRLRWVQVVPSGDELLQFLSPSVHSLHIIFRKAPTWSECVSLRGQPSEYEVYVRTLLKEVASRVPQLRYIRLSTTGDIHESWLEPLCSLRYLDTADLLERIYCDVTTSPLLRPLGSLQGLRHLKLRLPAGLPQDMEREAFPALESLVLDAMFAPLRTVSAFLSGVTSRHLSSLLIHGCECDTTTVSSTLYEVCDVVRARFAPSLRTLELAFRGVGPVVTHNQPLIQTIEPLLDLHDLNDVSISIAPEIAIVPATEHDLGRMAEAWPKATRLHLSYLPSAASPSLKDIAGFAQRCVGLTDLVLPGIDASASACDVKSETELSSLAAEYQQGKAAPHKLRSLCLSDSGWNSQIPDPMLLAKFLDALFPEVEWKCPPLASDHWRETIQEVLNLRIMRMVRERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTU2</accession>
    <name>A0A4Q9PTU2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTU2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="239" mass="24804" checksum="33D5DB60D82CD32D" modified="2019-07-31" version="1">MSELTSLSSLDLAGGYTQELSPQTVLQPSSSTLVSVPPQHVSRSSSPYDLPEVLSLYIPENARPKYGPGSSGLVMPLSISSGLPQQIPLSWAEFVDRSPNSLPAHPSPSPGSEGFAIETQNADTTTLLATSAISSCLDSITPPPTPDERTAAQALLCLFHSPPAPDLSSPASVPIPPSSFPEVAVTSSDPPSSEPPAGRVRAPAIASTSREAHTPTMDAQPARAISLSVFRFSPSMLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUB0</accession>
    <name>A0A4Q9PUB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_959163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUB0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF6">
        <property type="entry name" value="GABA-SPECIFIC PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="526" mass="55747" checksum="091AF563BBCFD5B7" modified="2019-07-31" version="1">MAPAPSIEKLDKSEVKEIVVQVIDSDDIRLAELGYKGEFKREFSLLETIAFAFSIMAVNGGVSSTLSFGLPSGGHVGMVWGWFIPCMFIMCVAASMAELASSMPTSAGLYYFSAKLAPERYSALASWITGWANVTGQVTLVCSIDYTVAQMITTAVAVGTDGSVILGAGPTYGILLAILVIHGFICSSATRILARLNLFYGFLTMAATIGAIIALLVCSGDNKVSTETAFGLFENNTGWKNNGWAFLLSFAAPMWSLTGYDSAAHISEEISGAARTAPIAILASVAAVGGLGWIYLICASFALASVPALLETKLALPMGQILLDVLGKRGMLAVWSFTLASQFLCGAAQGVDASRVVFAFARDNALPGSRWWKRMNPHTQTPVNAVWLVVVLSAFCGLLGFSATAFSSLAGASVIGLYTSYAAPIFLRITSGRDKLVPGPFALGRWFMPIGTIAVAWVSFVVVLLCFPASQTTNAVEMNYASVIVLAVFIFAASSWVLSARKWFVGPLPNIDATRALCTAKAQQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUM1</accession>
    <name>A0A4Q9PUM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_879511</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUM1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="371" mass="40621" checksum="2221F3C073FC5254" modified="2019-07-31" version="1">MADIEDTIGAILVGALISAILSGTVATQVFLYLKLYGTDDYKRNTFIVCTLWTLDSLHLAMVFASCWIYLIRNFGNTTICDYIPWTIALTVALTAIVTLISHCFFAHRIYMLSKQSWTLTAPIILLAVGRLAAALVSTSEMINLRSYSAFVSQVGWVFTTGLSLSTSVDVLITVILITLLQRSRTGFSTLTDRLIDVVTVYTLETGLLTCITTAVSLICWLTMPQNLIFLALHFSIPKLYATSTLATLNARKSLRRRTYPPDQHILPVISSLPSLPKAQSQTQRDLGEASDSQLKATNSTSPGRTRTVTPLDAKHVTGKDATPTHDIIDELGFAELGIRGPIPIPVTVSLPVPERTRTHARTSSLPLPLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUV1</accession>
    <name>A0A4Q9PUV1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TM7S3/TM198-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_495128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUV1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025256">
        <property type="entry name" value="TM7S3/TM198-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13886">
        <property type="entry name" value="TM7S3_TM198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TM7S3/TM198-like" evidence="5">
        <location>
            <begin position="102"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="355" mass="37979" checksum="DEC1BE2469B58B09" modified="2019-07-31" version="1">MAGLFRQNTLTSYLLTLLSCLLLLLTHVNNVCASPVAKDPPPVNYVDLAAHHWKRVTPIVVSSEVGDNVSVVNPTTDQVIPQGPGTDGGGTDFSLTAIIWLAFVFVIGIPLALAGIRLWRFTTGMGVGLAVAICLWAAFVNTVSSDGLSDIVLTVIPVGGFVVGFVFGMLDFGRWAGILLIGVLGGLSVGIRVVLLRPGLLIHAYLVNWLVLALFMIMGLSLILSRQHVGISGCCAAIGTFLIGLGIDLIIEKQDGMSFALRFLLDRNNSHFLAVVHKGYNPSMMTQIILGITLGATPVLAFAQHKIFKGPFRPERSQTDADMASLMDTESGIGAPEKPARVSRMQLLKSRFSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV59</accession>
    <name>A0A4Q9PV59_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_819367</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV59"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV59"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="387" mass="43376" checksum="AC76D772F5685D7D" modified="2019-07-31" version="1" fragment="single">LPLIWDQCIQEAVKDYEAACKKYDVTLRKHKDAAAKHEASLQALRTQVASPNLDPRERTKVDKKIKELTAKAPNPPLEPTPRMQEAEVPLMLSLGGALKLLLASPTSASDRQRGAHLLFSYLQQYKRIYGLQAMVPNHHFATHIPSQLEEYGTVYEIWAFLAERLNKTLKSTNQNNRRGGQQEVTMMREFDRHMQVRAIVEHVSTLSPDGTNEVDVSRSIAQRFLHELREARGTVEAIGAGQAHETAVQHDVFCLTAIGLGVRSARAVQVDMPLCDAILRWYTQNRAGTPEHHLYHAYDCNAPPGATFLDPTAHTLSYIILDGRRITPRTSSGIVKVSLPQHPYLAGDVARLLIHQQPGHSSPAVFAEVLWLVPQDIEQVANNPWRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVT9</accession>
    <name>A0A4Q9PVT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_926453</name>
        <name evidence="2" type="ORF">BD311DRAFT_751325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143396">
        <property type="protein sequence ID" value="TBU32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVT9"/>
    <dbReference type="OrthoDB" id="5410040at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031459">
        <property type="entry name" value="Coa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17051">
        <property type="entry name" value="COA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10437" checksum="91CFCC4B9C219F8E" modified="2019-07-31" version="1">MSSSVSRVLQLNNRQRRTFISSLFGFTFLASVITVSASAFLPCPANRGRYADGETRGMEGLSGRRSVTVVEKKPRRWIEETRPVPKAPQSNVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW92</accession>
    <name>A0A4Q9PW92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_818733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW92"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="465" mass="49913" checksum="CDF16FE54CF55E88" modified="2019-07-31" version="1">MAATPAPNPRASLLAGLRTGGVRSASGSMPNVPHTAAPAGTFNIPRIITPNQEDNFYPPEEEDELSDMMSQNLYIQNNRLRQAPVTAAVDGIPNRFQQQQQHVMNMNGMGYNYAMNQNQLQQVQLQLMQMELARMQALQAQQYQAELLAAQAAQQRQRQAQQGNRRAASNVIPSTAGPMNTTFDMRSVTMNAQMRRANQADQLRSKLGVSDDQVPMTAALNGRFGSRIGSGKYDEEDDFSSVGARPPATPSYTTVISGGTSLGAPATPTVQSKSDAAVSWRRAPGNNSVLSANRTVSSPTVKVTPPPGERVSPPPGLTIGKARPTPLRFTPETSNSGVAAVAIDTDGPEADDSSTSSKSNSSPSTPQSASSVDVPPLSPREEASKKLYEGLGLGRPVPGINVVVPQDSQMVVQRLISTPVRQPRGPPSNNEELVPKNFATRSRRKAVDSLLEHARERQVVVVEAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWI2</accession>
    <name>A0A4Q9PWI2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">guanosine-diphosphatase</fullName>
            <ecNumber evidence="5">3.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_818195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">After transfer of sugars to endogenous macromolecular acceptors, the enzyme converts nucleoside diphosphates to nucleoside monophosphates which in turn exit the Golgi lumen in a coupled antiporter reaction, allowing entry of additional nucleotide sugar from the cytosol.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GDA1/CD39 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.42" evidence="5"/>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWI2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWI2"/>
    <dbReference type="OMA" id="WTCRIKE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009134">
        <property type="term" value="P:nucleoside diphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24040">
        <property type="entry name" value="ASKHA_NBD_GDA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.150">
        <property type="entry name" value="Exopolyphosphatase. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000407">
        <property type="entry name" value="GDA1_CD39_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782">
        <property type="entry name" value="ADENOSINE/GUANOSINE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11782:SF83">
        <property type="entry name" value="GUANOSINE-DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01150">
        <property type="entry name" value="GDA1_CD39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01238">
        <property type="entry name" value="GDA1_CD39_NTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="52"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="277"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU59013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="548" mass="60503" checksum="0A89980E860A7E1E" modified="2019-07-31" version="1">MGPSKSGGGRRFAWKKFAIGAVVLIGLVYFFGPRKEDLDDYVPSIMKPDARPAEDAIYPPAPGPTTKHTGQDYPATQIPHDNDVSTAPETRPTDPASDGDLTKTHYCTQPYKAGVPLVQFALMIDAGSTGSRIHIYKFNNCGPSPGYEYEVFKQRQPGLSSYRGDPEAAAKSLDELLEEALRVVPESLRHCTPIEVKATAGLRRLGTQEAADILAAVRRRLETAYPFSLAGEHAVEIMEGRDEGVYAWLTANYLLKTLSAEAKAEQRQPYAVLDLGGASTQIVFQPTLDMAKPDASLEEGEHKYELKYDGATRVLYQHSYLGYGLMTARQSVHRLVEFMNGLRGASHGKDAFVANPCLAKGTQRLVEIDDQRMGEKFNVTMMGQDVGDFESCNRVVELVMAKDAVCNVKPCSFNGVYQPSLLETFPHGKILLLSYFYDRLNPFLAAKVNAPKQPVHISTYADLAKTVCEGPAAWKELWGADKDLMDELEGRPEWCLDLTFMHALLRLGYEFNADREVELGKQIDGTELGWCLGATIKMITGAELKCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX08</accession>
    <name>A0A4Q9PX08_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_948176</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the peptidase A1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX08"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05488">
        <property type="entry name" value="Proteinase_A_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033819">
        <property type="entry name" value="Saccharopepsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU59069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="412" mass="44339" checksum="D03561906D572DAE" modified="2019-07-31" version="1">MLLSRLAPLVLLPFAAAAGLHKLKLKKLPPASSNPALESAYLAEKYGGRSQVPLMGAGTGRNVRLSRPAVQDGEELFWTQEEFSVEGGHNVPLSNFMNAQYFAEISLGTPPQTFKVILDTGSSNLWVPSVKCTSIACFLHTKYDSSSSSTYKANGTEFSIQYGSGSMEGFVSQDTFRIGDLTVDGLDFAEATKEPGLAFAFGKFDGILGLAYDTIAVNHITPPFYHLINKGLVDEPVFSFRLGSSEDDGGEAIFGGVDDSAYTGKIQYVPVRRKAYWEVELEKVSLGDDVLELESTGAAIDTGTSLIALPTDIAEMINTQIGATKSWNGQYTVDCAKVPSLPDLTLTFGGNPYVLKGTDYILEVQGTCMSSFTGLDINVPGGSLWIVGDVFLRKYYTVYDHGRDAVGFALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYI6</accession>
    <name>A0A4Q9PYI6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_924329</name>
        <name evidence="2" type="ORF">BD311DRAFT_766838</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143483">
        <property type="protein sequence ID" value="TBU24292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYI6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU24292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7876" checksum="99165B1E6A70F08B" modified="2019-07-31" version="1">MHDHCGELRAMLLDNVTWVCVYPVVFCSIATGTLSAVSHPPVSRGLAPLPVFLGESRPGEYSCGMWRARSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ51</accession>
    <name>A0A4Q9PZ51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1005808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ51"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZ51"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="43679" checksum="0B45E44EBECC7729" modified="2019-07-31" version="1">MYPSQVDIRTLYSYTRNEGVHKYDMKPNASLRKKLVAELDMTPRGVQVRLSPSRPLGVPSADQQFDALHPPFFNATSDVNGSTIEITLSSMRLLTVRDVSTGSTASSIGPSSGAGIPQAAQRLSVNLAHLIMNAQGRPSSILSSGSSLQSLSTISGISVDSTGCSARSSSSSVVSHDHEKEHKEKEEGKKTSRESRRSSESHWRTPISEIFPETQVDVQRQSTGSPSPPGSLMDHPMVRMEEATADGHSPPTDNEKLSSHCSTLRRTTSLINYLNLEVTPGSITGTPLNLTPWQHASQESPLRRCAMLQRGSLLKGELHLPRVIKLSHMQSKASQLAGQQIAPWNELDWKVSPWKLIVKPKPAAHLTHKCTLTPSPADAGPVFQPPCPAKAKAKTSLLTSELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q023</accession>
    <name>A0A4Q9Q023_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Piwi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_1037985</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q023"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q023"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="319"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="613"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="981" mass="109039" checksum="3BB0528A9754AAC6" modified="2019-07-31" version="1">MSQPRGGPRGRPGAQGQSPGRGGRGSSPSPRGRASPVPARAVYGVSRGRGARGDSTSTRGSSRGGSRGGAPAEVFAASQPPNQDARLADAELDRLVQSFKSVRIPPDMPLRPGWGTQGDPGVVRTNFFAIRLPQNATYYEYEISIQPKAQAKGDRRFRIMQLVEQSPQFRPYVAQVAHDRSQRLVSIQQLPQPLEIPIRYLEEDQADDPNALNFTVEMKLLSKLDMSQLNQYMSGKPEHRNIDTQPLLSALNLVVQQYAQRHGVRVGKNKYFFPTSSEHHSLSLGVEAFRGFFMSVRPMYKQLMVNINLCMTAFYNPGKLADAMDAFQRQSRGGMPNSFAEKLKVSTKHLGFTRKFTIYRIMNGKTARKETFDCQEFGGRITVENFFKRKYNITLRRHSDLPLINVSTNRKKPIYLPAELCDIVPGQAYRGKLDRDQTAAMIKVACNPPAFNGNTIVDQGFADLGLRPNASGATLGTFGISISPDMQVVPYRRLPPPAISYRVGRPRVQDAGWNILDVKFQVGGNMTNWAVLLVQDGRRDEFQGPNDPALIAFLKAFLAKCNNSGILGADKPPRIMSVDLPRLDQDTPTRAQAIAAISKVFRDNLNPKQKPSFVLVLLSGIDKYIYPGIKQLADVELGIHTIHMLLTKARDDRGNRQDQYFSNVALKVNTKLGGVNHQLDDRSMQWLRGVGGNGPATMIMGIDVTHPSPLSLPGTPSVAAVVASVDSHFAQYPASLMLQKPDWNKESKEMVEGLTQMTIERLQLYQKKNGGKLPERIFVFRDGVSEGQYPQLLSIELPRLQAAFKQISPLKPYKPKLSIIVCGKRHHARFWPVDSQHATRNGNTFPGTVVDKGITDAYDFDYYLQAHSGLQGHVKATHYVVVYDENKLDADTIQQGTHTASYMYARATKAVSLIPAAYYADIACERGREYLNVLMNASDDSRSSAAETADREAQKEATFQSAVRMWGNGVNKELKDTMFYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0M5</accession>
    <name>A0A4Q9Q0M5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_922464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0M5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8622" checksum="6C29908C0BE7B7B1" modified="2019-07-31" version="1">MTSPLATERRRNTTQAANFCICRQKPEARATYNHTRYRNRQSYKPLRRALVASETVAPGRLQASEARTTQRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1C3</accession>
    <name>A0A4Q9Q1C3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">BD310DRAFT_308546</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1C3"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1C3"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:001062">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="22">
        <location>
            <begin position="52"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="23">
        <location>
            <begin position="502"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="57"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="446"/>
            <end position="447"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="TBU60636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="638" mass="70184" checksum="E49AF971747A3429" modified="2019-07-31" version="1">MLRKSLNKGLRASSARSFHSSAPARRVVATNPVKAQEVQSFGKYPLIEHEYDAIVVGAGGAGLRAAFGLAEAGFNTACITKLFPTRSHTVAAQGGINAALGNMTEDDWRWHMYDTVKGSDWLGDQDAIHYMCREAPHTVIELEHFGVPFSRTKEGKIYQRAFGGQSLKFGKGGQAYRCAAAADRTGHALLHTLYGQSLRHNTNFFIEYFALDLIMENGECVGVIALNMEDGTLHRFRAHKTVLATGGYGRAYFSCTSAHTCSGDGNAMVARAGLPLQDLEFVQFHPTGIYGAGCLITEGSRGEGGYLLNSEGERFMERYAPTAKDLASRDVVSRSMTIEIREGRGVGPEKDHIYLQLSHLPPEILHERLPGISETAAIFSGVDVTKEPIPVLPTVHYNMGGIPTRYTGEVITVDENGKDKVVPGLYAAGEAACVSVHGANRLGANSLLDIVVFGRACAHHIKETLTPGKPHKEIPAEAGLQSVEFLDQIRKSDGPLPTAKIRLDMQKAMQADAAVFRTQETLDEGVQKLRKIYKSFDQVGIKDRSMIWNSDLVETLELRNILQCAVQTITAAAARKESRGAHAREDFPERDDEKWMKHTLTWQRDVSSPEVDIKYRGVIHNTLDENECKSVPPFKRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1D2</accession>
    <name>A0A4Q9Q1D2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_309260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1D2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="140" mass="15674" checksum="DE67167C4EC7D0C2" modified="2019-07-31" version="1">MWRIQPQSRSGDPIYSITGALRLTAFANMWRERQKSVALPFETCSRDWQSCSRRAISLLQSTPFLPSCSTWHFGTYALLVIQEDASSIRAYEIGCDNTTITHECVHHGDGPPGDRLGLRFIVGALREYGPNLLCPELATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q237</accession>
    <name>A0A4Q9Q237_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Purine-cytosine permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_813764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q237"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF5">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="497" mass="53726" checksum="75258BBA07EB9949" modified="2019-07-31" version="1">MGSSLEVEKTSNISDDQANELVATKPPTWLTKITKFVAHWGVETNGIDPVLPEERKDTRMYQMFFVWFSANINILTFGTGSSGPAFFGLGLRDSLLVILVVDLISCAIPAYFAVFGPKLGMRSMVLARYSWGYYGSIIPSAFTVFSMQGFLILNCIVGGQTLASVSSHLNDTLGIVIIGIISLVVTFFGYRVIHWYETVAWIPSVIAFIVMLGTGGQHLGSHVPPGEPASAASILSFATTVASSVISWCVMTPDYGVYHTSKASATRVFLYSYAGFLVASLVAHMLGAAFAAAAPGVPEWETGFDNGNSVGGLVEAVLSPAGGFGKFLTVVIALFIPSACAPTMYTFASSFMTIHAWLGRVPRYIYTIISEAILIPVAIVGATHFYTTFVDILNAIGYWSTIFAAIVIVEHLTFRHNDWEWYDLSQWNRPRELPLGLATIFAFLCAAGIIVPCIDQAWYVGPIANTGTGDIGVIVGFALAVICYPVYRAIERALSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q278</accession>
    <name>A0A4Q9Q278_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytoplasmic tRNA 2-thiolation protein 1</fullName>
            <ecNumber evidence="6">2.7.7.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cytoplasmic tRNA adenylyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">NCS6</name>
        <name evidence="6" type="synonym">CTU1</name>
        <name evidence="7" type="ORF">BD310DRAFT_957103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="6"/>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q278"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q278"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="CTU1-like"/>
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        <property type="entry name" value="Cytoplasmic tRNA 2-thiolation protein 1"/>
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        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CTU1-like_ATP-bd"/>
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        <property type="entry name" value="Ncs6/Tuc1/Ctu1"/>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
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    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020554">
        <property type="entry name" value="UPF0021_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00269">
        <property type="entry name" value="TIGR00269 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16503">
        <property type="entry name" value="zn-ribbon_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01263">
        <property type="entry name" value="UPF0021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="357" mass="40131" checksum="AE942A8AD18ACB94" modified="2019-07-31" version="1">MPPRLCALCHAVRAILKRPKTGQQICKECFFYVFETEIHNTVTEAKLFKPGDRVAIGASGGKDSTVLAHVMKTLNERYSYGLDLFLLSIDEGITGYRDDSLETVKRNQQQYDMPLKILSYDELYGWTMDAIVTQIGKKNNCTFCGVFRRQALDRGAAILNVDHIVTGHNADDIAETVLMNIMRGDIARLGRCTSICTQGEDTIKRSKPFKYAYEKEIVMYAYFKKLDYFSTECIYSPDAYRGHARAFLKDLEVSRPSAIIDIIHSGEAFEIKEDVKATQKSQQTCRRCGYMSSNELCKACTLLEGLERGMAHAVATDRGRKKLDADDHAPENLRTIPFFQLPASSRPNSTAPIEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2Y5</accession>
    <name>A0A4Q9Q2Y5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2Y5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="78" mass="9373" checksum="CE022B411A02D8C5" modified="2019-07-31" version="1">MSPIKYVSFYRLSFLTSRTHFRTRHAAKNMAQRRLLPIHRYTVENPRSTCRNIMFRRTLFIMTFLSCTSANCHEQRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3G1</accession>
    <name>A0A4Q9Q3G1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_812569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="90" mass="9820" checksum="2FE087ABA9BAB65A" modified="2019-07-31" version="1" fragment="single">SFARKLARFITEKPCKTPEWGLVLSQLNRKPKIDVHRGPMCAHLGTASGLQESTLRPMAGASPKGARPDSEVNERLQSNGLLDNPALNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3L5</accession>
    <name>A0A4Q9Q3L5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cyclin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_873625</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3L5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3L5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000076">
        <property type="entry name" value="RNA polymerase II holoenzyme cyclin-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 9" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cyclin-like" evidence="11">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="264"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="282"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="373"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="440" mass="48417" checksum="9EAEC8CDE3FC40AB" modified="2019-07-31" version="1">MATNFWSSSHYKRWIVDRATLHQARYYDLQYADSPEHLGFLNIFFANLISKLGKKLQLRQRVIATATVFFRRFYVKNSYCETDPFIVIAACCYVAAKAEEAPVAIRSVVTEARTLFGDEYGIKTFPSDNSKLAEMEFYLVDELECDLTVFHPYRTLVTLCGKEGGVSLPQAEAGEADADDSDGPRYWGTGEGKLELQEGALQMAWYGLPYCPSPQAQDAQAPVRFIINDTYRSELCLLYSPHLIAIAAIYLTLVFHAPTRASIQQPASSAPSHSGSSHHSHSGSPTRRSSRSTTHSQKKQQQPQDVIGFMAGLNVSMTLVATIAQEIISLYALWDRYSEDVHADSARSSFLHKSGSASGGTRRGGVKAGRSASVVSSGTITSGNTPSTQDDSAQNEIVTPMSLVQLLLRMREQRMTDLAHPPSGRPVAVNKMLERTQAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3M2</accession>
    <name>A0A4Q9Q3M2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_813020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3M2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3M2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="40464" checksum="7E3DBA743AA18CC8" modified="2019-07-31" version="1">MKYTIIATLSLALAASARPSFISAKRAEFTLKNGQDAIALNDKFKTLTPDSACSTGDIACVDDKFAQCVSGKFVLQQCGGGLICAALPLVNSAGTSVTCTSAADRDARIAATGAKDASTGDNAATGGAAAGSSSAAASTSAAASTSAAVSTSVAASSSAAVSSSAVSTSSAAAATSSAAAGDNATNGTAVGADAQTSLTLDPNSIQPNYASDGNANATAGQEPSLTSTNNFINFCLLFPDKQKTNGAQVLDGSCNQTPMGLIAAKANMPSAKFQSPKNGDTIPANKDFTIQLAINNLETGHFTNPTTTFHMAPQVVNDQGLIKGHSHVVIEELTSLNQKTPTDPTKFKFFKGLNDKATNGVLTAVVPGGLPAGFYRAATINSAANHQPALVAVAQRGALDDMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4B5</accession>
    <name>A0A4Q9Q4B5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Small GTPase rac1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_1036685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4B5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4B5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000088">
        <property type="entry name" value="Ras-related C3 botulinum toxin substrate 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU62045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="193" mass="21317" checksum="BA9DAC2CE935A413" modified="2019-07-31" version="1">MQAIKCVVVGDGATCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKTISLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPPSFENVRTKWYPEISHHAPSTSIVLVGTKLDLREDPATIEKLRDRRMAPIQYSQGVQMARDIGAVKYLECSALTQKGLKTVFDEAIRAVLNPPPQPTKKGNKGSKCIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4H2</accession>
    <name>A0A4Q9Q4H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_812274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4H2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5543" checksum="1FAA3712E6AD1060" modified="2019-07-31" version="1">MGAVVWVPVHTAHMLIGSKSSRAQGLRQFGATCGNEKGVPMAGEHPPGATRGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4M1</accession>
    <name>A0A4Q9Q4M1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMAD/FHA domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_871781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4M1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4M1"/>
    <dbReference type="OMA" id="WQKSCWL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000038">
        <property type="entry name" value="FHA domain-containing protein SNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="213"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="35367" checksum="B49B0053B7D9017E" modified="2019-07-31" version="1">MQRDSPRESYKDSRGQSTHYRDDRRDRYSRRDDDYERGGSRRDSGRDYGKSRDGLSSYKRYDDGRDRDGRRDRDRDRYRNENRDEEGGYGRGRDRDDDRRHDTDGDQRRDRDDHRPGPSRRSASPRARSSKPESPARSKSRSVPAEDKAKPNFGNSGLLAAATKTVQHGDGTKTVLKYHEPPEARKPAVGWRLYVFKGKEQVDLLHIHRQSAYLIGRDKAIVDIPIDHPSCSKQHAVIQYRQVQEKNEFGEVKPAIKPFIIDLESTNGTIVNDSPIPTSRYFELVLGDVIKFGESAREYVLLSEDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4N8</accession>
    <name>A0A4Q9Q4N8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_126213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4N8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="8813" checksum="7647AE3D356177FE" modified="2019-07-31" version="1">MSARSVQATSLAPPLSSLGIPTFTSMASAETRRSSALLFSVYFRRAFLTSVNFFEVLLSLSPARHRVVAFCHLVPRGWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4T6</accession>
    <name>A0A4Q9Q4T6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_812087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4T6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4T6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="31926" checksum="6FFB276F5BBD9689" modified="2019-07-31" version="1">MAIATLPTPHDVHTTLNYYKPLDGDASGEAYRYIYTAPPPGRPEHNLGDDPRPVVVHDARGREHDFALDVHGFQFLRHPSAESEFTDEARIRDVYYKEGEELLKRVTGAKKVVIFDHTIRSVRAHGRTRRERVHIDQTYEATIKRVHQLLGADAPRLLQSRTRLVNVWRPIANPVFHRPLAVSDWRALDERADLVPVTYYYPDRVGATFSVRYNPAHKWWYLSQQTPEEVTLIKCYDSLTDRARLTPHSAFWDSTTPEGAPHRQSIELRALLFDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q568</accession>
    <name>A0A4Q9Q568_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_918635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q568"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q568"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00047">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="2">
        <location>
            <begin position="85"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="281"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="404" mass="44493" checksum="04F835984CE74F11" modified="2019-07-31" version="1">MSGTIPGLPGWLERSHNLEHLTAVLRTLAKRERTRRSARSASQHPSHPLKRHWLAHLASTVQTNAEHVAHYSIAVGSDPAYAPLNRYADIYPYDRTRVVVCPGDDSHACGSGCEAGRYLNADWVRELWGGKWWVATQAPLPQTAHTFLSMLVEGISPPPSPNDPASVAENRNLRSERRIRTVVQLTQNLEGGMRKAHIYFPPVEGQSWVIEPVEGRADPIEVTLVRAQTVDEAHCVRSVVRLQLLSPERAPVGDPVLFQHLLYASWPDNGVPAREDREGLLRFAKLVDDANRDLSLYTGIADLDPNPPIVANCSAGVGRTGAFIALCSLLRHYGFLSPPGTEGSQAKISPLPESPLGPLPDELKDDLIVQEIDSLREQRPGMVQRDDQVVMIYEALIAAFVSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6E7</accession>
    <name>A0A4Q9Q6E7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6E7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="84" mass="9098" checksum="6A87482AF3E66F83" modified="2019-07-31" version="1">MSSTSFMIASFGAPGSHSWSLSASPGNMRFFLSSSSSPGPSTAPFSFPVDFFLCFGWRVRMRRSTFSTNDSGKLAPTSRLVSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8G2</accession>
    <name>A0A4Q9Q8G2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GDP-fucose protein O-fucosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_808030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8G2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8G2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020334959" description="GDP-fucose protein O-fucosyltransferase 2" evidence="10">
        <location>
            <begin position="31"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="481" mass="55459" checksum="7314B047A9346F2F" modified="2019-07-31" version="1">MSYLPRRRLLGALFSLTVLSFVALSVTTFGRVPEETFQVTPEHGNAPPQQHETNDRRPEVDLTHPPLPPAASEPDRDPVSEEEYSYSPRLVGPPTQSFRDNLRNDTKYITSWPSAGWTNDVMTYANLIYLGSLTERVPIIPMFTPSHIGGDAAPIPFGEVFDVPRFIEESGIEIVEWDEVKDPESNVVDDLGCWNIWEAVQYREHHPRPSAAPDWLKLDLSYTKAPDWVKLIPNYEHDSCSTFMALTRLSYPEERSRNIGHALPSPLHNAVLDPEEHVLCYDYLYYACAQQSYEYDFDYAPMWRYVLRHFHWTQRIELITQQYVREVFELPPGTNMPPFIAVHIRHGDFSNWCWAAENPEDCFAPISAIERRVKEVQDELRERKGLDVDRIFISSDEKDPAWWDQIKALGWRTVDHDAMRTAAVYGRWYPVIIDAAIQSAAVGFVGTDRSTYSIVSRRRVQSWQDGVTRVLKWGFKGADDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q910</accession>
    <name>A0A4Q9Q910_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_916601</name>
        <name evidence="13" type="ORF">BD311DRAFT_768298</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143502">
        <property type="protein sequence ID" value="TBU23549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q910"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q910"/>
    <dbReference type="OMA" id="NACPLDN"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="52"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU23549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU63531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13582" checksum="7AB2963C27C28AA4" modified="2019-07-31" version="1">MADTMDVDVDPPTTAEPKGKTKEDAKGDKKRFEVKKWNAVALWAWDIVVENCAICRNHIMDLCIDCQANQVSATSEECNAAWGICNHAFHFHCISRWLKTRNVCPLDNREWELQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q997</accession>
    <name>A0A4Q9Q997_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein serine/threonine phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_955229</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the PP2C family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q997"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q997"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="5">
        <location>
            <begin position="50"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="407" mass="45760" checksum="2F767F6E92D55408" modified="2019-07-31" version="1">MALLLPSRSPSLLRSLPRLTHPPRASYHDYIRISTPDGGTARLPLNNPNFIGVANFRGERRYQEDFYAFAALSLDPEELRLSYKKAHNLDWVPSELPTTLARQMLFVGIYDGHGGSTVSQFCRQELHGLFENVHKSQVPEVYAWAKELGGYFRRFTGGVLSPWLDQNAESYQQELDLEARATLAFFEVDKILSEEKEAKECGATASVVFLKSLDNLGYFQSEHLALTVAHVGDTRVLLTSTEAGRVKPMTENHHAESRVESVRLRRMMGGLTTDSFGEVRWMGVLANTRCLGDLKFKPYGVTPEPEVRHMLLEGQQWSHITLISDGVSSVVSDEEISDLARGALSPKHAAERICSFAEEMGSEDNQTALVVPLAGWGKITGPDRTKELREYRRKGLEGNERHRGRWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9U1</accession>
    <name>A0A4Q9Q9U1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Gti1/Pac2 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_806568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9U1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF1">
        <property type="entry name" value="CAMP INDEPENDENT REGULATORY PROTEIN (AFU_ORTHOLOGUE AFUA_3G09640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="35248" checksum="15DB6AC12849B92F" modified="2019-07-31" version="1">MQLPTCTGIRIRSLSDAHVIFHAVTLGLLPIVSRRLDIEERRYIHSGCVCVWEERSACGEGASSVGIERWTDGRRWGPSRVRDEFLYYQEKLPEFEADEELSSLIFGSRLIKQTYSVYVDTPTGRRKWHLVAYFTGETLERLLTVDEIPELSAIRHLVPPGKYTTARMARQRARPESSGPPLFGQEFKPIPLSSSSSSLSSLASPTSSRSRIPLYTIDRGDMLSPPSSTPSPQQTDLHLPALKPPPWSPPRWFEDELATRQPDLNCAQSQRLRRNHTIDLAPLIYLRKHPYPPRDVADDDILQKFDCEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9W4</accession>
    <name>A0A4Q9Q9W4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9W4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="99" mass="11656" checksum="9B2AB7811470789D" modified="2019-07-31" version="1">MVLYFMTLHRSKCVHDVDDEKGMYNAICRARALCMKTKQEDAPGRVYWRRHPNGLEQASRRYYMKVLARRIRGIRRQMLTHTSIIITTLRMAASTSHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA30</accession>
    <name>A0A4Q9QA30_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_914759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA30"/>
    <dbReference type="STRING" id="114155.A0A4Q9QA30"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF8">
        <property type="entry name" value="7ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU64497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="32443" checksum="B9A25F4CDC9C62EB" modified="2019-07-31" version="1">MSADLFSIANRVMLVTGASSGIGSYVAQGLARAGAARVYITGRRAAQLDSVAQAVPGVLVPLVGDVSTIDGCKALADAFVSAERRLGVQDVKLDLLFNNAGMAVAEGFWGSSASGEQIRDALLQVDDKDWATVFAVNVGSLQVKFCTILTRRLLLNVGALRQWLSAALLPYLIAASGNNGKAEGRGCITNNTSVSAFFVSPQVQGHLYAASKAAAESMSLNLASKFTRLGVRVNSIAPANVPSELNSPDNPRSFISLMKDHIPIGRIGNQDDVVAVVMYLASRAGSYISGNVIKVGVHLLPSRFHLLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAY9</accession>
    <name>A0A4Q9QAY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_943807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAY9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19360" checksum="192C11E45083D6C2" modified="2019-07-31" version="1">MGARQPNRVRIGQRGLDGKPLGMTSLAATDIPRRPLYTLSALSHFPSLLHLHILYLPIHTIARVRPVWIKKPPSLPVPITPLTMTSLMTVATTPAPSPFNPMASRPRVSSPLAASAQANPVSSRNHSFPTSRPLRPFPSLAIKPSTPARKPVKILEPPANFKGAFVLNLTPAELSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBW8</accession>
    <name>A0A4Q9QBW8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_914056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBW8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="11255" checksum="AEFD8CFE72390B6E" modified="2019-07-31" version="1">MAPSVHVDDDVDAADDTSPSLRGRLEVSTAAPQVDQLSVAWPGKASSFPASPACSTPTELEGQSGDSEELGAGSGLLTFVQGDDDLPPVVLKAKGRAATYPLSGVRKYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCV5</accession>
    <name>A0A4Q9QCV5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_864266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCV5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="215" mass="23954" checksum="05918503F69B9795" modified="2019-07-31" version="1">MSLIVHAPRPRNSTKGLPQWDIPSDVDEPIALVRELSSPETIIKPKELHLAFKWGPLNSTRFSRFRKLKPTPTRRRYEGPAAHMPLPRGMSRSSTMCSVRSLATLSRTVSVDVGVLIVRPLRREGTYIVWGAVMAPEAYNPHFTTPRNVLVKIAVDEEGGEDLREDARLHEQLAERGMTSGYYGVFVDSIGSTALVTDDWDNEVGEVHTPTPSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD03</accession>
    <name>A0A4Q9QD03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_953764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD03"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD03"/>
    <dbReference type="OMA" id="LLMIHIG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25652" checksum="381E579AC788339E" modified="2019-07-31" version="1">MELSPGFRRVRTGVFALTTFVSVLWVVLLSVEIFVLYDRSDAAQRNLVAILIFINAITAIMLPVLSIFQFRAWLDAARLLFLLMIHIGTALLFTIWNATFQCPADASQRRDCRSVNIAIVACAWVVPFLLIWYAAFLAVTYRMWHNDRKKPDEELSEKRLSELPMMLPSSRRPSLGPEMQLSSNASNVLPASRKPPPPPLQRPPHPLPLPPAHTFHSNAIISVKSAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDG6</accession>
    <name>A0A4Q9QDG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein transport protein sec16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_803264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SEC16 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QDG6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09233">
        <property type="entry name" value="ACE1-Sec16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024340">
        <property type="entry name" value="Sec16_CCD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024298">
        <property type="entry name" value="Sec16_Sec23-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402">
        <property type="entry name" value="RGPR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13402:SF6">
        <property type="entry name" value="SECRETORY 16, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12932">
        <property type="entry name" value="Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12931">
        <property type="entry name" value="TPR_Sec16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Sec16 central conserved" evidence="10">
        <location>
            <begin position="376"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Sec16 Sec23-binding" evidence="9">
        <location>
            <begin position="582"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="151"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="256"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="909"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1038"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1110"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="267"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="912"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="936"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1056"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1079"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1160"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1221"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1252"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1302"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1321"/>
            <end position="1330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1348" mass="141466" checksum="EB96C08E65523447" modified="2019-07-31" version="1">MNGSAHMTYQPSYGSPVNHGGAHGAGGPFGGGAHAGGDHPQEGLPQVNDTYAPSAYTGLPQEASPSMVPSAPAHDIHAAGYGSPVSTSSNGPAERVASPLRNAVPEVEEVEVYKSAREFAAPIPAMSSSPPTSAGLRPVAESAWPNEAVYQPQLSSSPERTRSPPQTVPPSISQAPATAYDPYAPKSSTSDRAKSPGASSVHSVQKAYEPPRRDSATKASPISRPLSSQSRRSTLSNAYEPQTAYDLKRAISPAGSVRSVTAPKQGAYDPYAPADKPAAAHGRQTSNGSMYSTTSATDPYAPARYPTRQSSEHTYGSFVLPSQPSSLSANGAPPTATYDRTGGQVVTLAPQTHSHYAPSPSLLGTNDPLGRTSARVPVISFGFGGKLVTCFHGANMNTGFDVALSSRQSTDIKIHLIHKVISESVLDTSAASYPGPLYSDPGSPTASLVRTGAQALKAKKARVIKYLEDRAEEINGGLGYHKPGSVDRSRAEAKRILVLLLKAMVENDGRLSGNAQVDAAVRAALVPQEGVSSTSEGSLGSGLIPATSTEHLSGFSLASALPNASDHVVTTTSVRASQLDKISDLLARGDRRGACHYAADEKLWSHALLIASSVDKECWKEVVTEWIRAELVADPAQPQDGKHGREPLRVAYSLFGGNGAAAVQELVHPSSLLQHGQTNTLQIPQPQLNITPMTPNFPTAVTLNISQEVLASWAKTAAMILSYPLTPESSQALTALGDQLVVHQWIEAAHACYLLSPQTSPIGGGSRLTLLGSPPPSLSPTFYKDPDPIIFSEILEFATSLATPAKGQEPFNGLPHLQPYRLIRAASLAEIGHVQLANRYCEAITACINRGSPVLNITFVEQLKILSDRLIAAPQLDKSGSWIGGKMAKPSLDSIGNWLEGRFTKFIAGETDSPRPEEAKSLEQQQKSYSGPFANYSSISSATTSAYPSPHQSVTDLSDVPPVPAPPFRTGSAMGLNRPPSRTTYPINRSSSAMDYVRPFQQQRGGSPIARVASASAATFADATFNGQARGPYGYSNGYSPASGFDQPKDSDSHGDVSSTNHSKLPSASSWWGASEPDATTPTASSFGPSSSSTSNSEFISLMDDPMLSMTPTAAKMTGSSAPRHSFGDDDDDLGLGNASSRKKPKSSENGDAAHGAVSSKEEEKTKAAESQKPAEVKQSASSGWLSRLWKRDSSSPAPVKANLGEQSSFYFDKELGKWVNKNSNATESKPTPPPPPPRAQTVSPGRSFGAGPPPPSPLTAGPPPARPATAGAIDLSSEPPRRPPTRIRSNLVPNDAADQPSAPPSPMPTPGTPPPGNGPPAGRARGGAAKRAVRNRYVDVFQQEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDU0</accession>
    <name>A0A4Q9QDU0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_30292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDU0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="16510" checksum="A6F87D104E3B01F0" modified="2019-07-31" version="1">MQIDCAGAGRRDESVLLVPSENWADAGSTTTSSLAGIPHGKHSRGIHCSLQMESLQMEPIPSAQAGLSRPTVLPSQKNRTTPATLPADFQVPIRGSRRHLYLIAAPAQTVSTFAERMDSPRVCRHRLLAIGTSPRLLVGGPDVRIINPSSAGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QF60</accession>
    <name>A0A4Q9QF60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_912586</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QF60"/>
    <dbReference type="STRING" id="114155.A0A4Q9QF60"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="90"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="176"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU66020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="27354" checksum="8B0E21CE08D53119" modified="2019-07-31" version="1">MATAPKSTASEKPKSTATDKPKSTAEKPKSSDKPKSAAAERPKSQRTADKKTTEKKSTPKAAKPAGIKKPKIAAAPKKAKAAKPADDGKAHPTWKEMIKECIVDSKERTGVSRPVLKKMIQERYGLDAISDNVESSRFTRAIQNGVEDGTFALPKGPSGKVKLAPKTKPEPTNENAAPAPAKKAAPAKKAAAPKKTPTTAVKKAPAKTAKTAKATSTTKKQSTAKTTEKKKTAAKAAATKATKAKSTASKPASKPRAKKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K1M9</accession>
    <name>A0A4V2K1M9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Beta-xylanase</fullName>
            <ecNumber evidence="13">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_810461</name>
        <name evidence="18" type="ORF">BD311DRAFT_652512</name>
    </gene>
    <organism evidence="18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
            <strain evidence="18">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="13"/>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K1M9"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10 13 18" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8 13 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <keyword evidence="6 18" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040598474" description="Beta-xylanase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="16">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="17">
        <location>
            <begin position="86"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="75"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU62813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="401" mass="42711" checksum="93C598964E2D2E9B" modified="2019-07-31" version="1">MKFSATFSVLAAVLPYALAQSQEWGQCGGIGWTGPTTCVAGTVCTVMNAYYSQCLPGSASPSPTSTPATPPKSTPPTSTGAPAPSGSGLNKLAQAAGKKYFGTATDNSELTDTAYTAILDNIVEFGQLTAANSMKWDATEPTRGTFTFSSGDQIANLAKANGQLLRGHNCVWYNQLPSWVSNGQFTAADLTTVIQNHCGTLVGHYKGQVYSWDVINEPFNDDGTWRTDVFYNTLGTSYVEIALNAARAADPNAKLYINDYNIEQTGAKATAMLNLVKSLKSSGVPIDGVGFQCHFIVGEVPTSFQSVLEQFTAAGVEVAITELDIRMPTPASQANLQQQQKDYQSVVQACMNVEGCVGITLWDFTDKYSWVPSTFSGQGAACPWDQNLVKKPAYSGIVAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K3V1</accession>
    <name>A0A4V2K3V1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145201">
        <property type="protein sequence ID" value="TBU53942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K3V1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9342" checksum="A0B22C5F4620C283" modified="2019-07-31" version="1">MHRAKASGRVGPEHHGHASTAKARGRLERAKDAVAAKITATKREKARLRKKNKFSDRQNAQKDATASSGEPVDCNGSKSMKRVTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K3V6</accession>
    <name>A0A4V2K3V6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_962464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145240">
        <property type="protein sequence ID" value="TBU52692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K3V6"/>
    <dbReference type="STRING" id="114155.A0A4V2K3V6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="348" mass="39074" checksum="02A8579F9BF9D365" modified="2019-07-31" version="1">MSIEAATKDGALFHEFVEGKELRLSLPNAGSSSSTAPALSCTIMKAFRPFTMSPVLLVSLIQPSTPTHGDAVLPTTAIIKLYDRRCLSNVRDEFDEGKPWSLDKEQEYRQYLDDVATGSVARGDFDSPTFMWDNDVSDGEFEAYLRRVAQRMFDAERTAYERLRDLQGKKIPRLYSVVEYEIAIPNARGDGAAVTDTIPGLLLEYVSSLSLRQLVATWTARNPPLANEVLAVLCEEAVKVVDRISDFDVLNEDVRVDNFLIREPFIDATSSTQGGNAAVVENAVVLIDLGLCRLRREDESEDEWIKAKWSQDEAGAVGFVLLGLVREFIGENVWKYERSLRYYRPLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4U8</accession>
    <name>A0A4V2K4U8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_920580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4U8"/>
    <dbReference type="STRING" id="114155.A0A4V2K4U8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II elongation factor ELL N-terminal" evidence="3">
        <location>
            <begin position="93"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="736"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="456"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="697"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="812" mass="89366" checksum="EF5CA7CBC7185BD2" modified="2019-07-31" version="1">MPLPANSTVLLQGSSQPGDPLGYKPKQAMLIRMTQETFEALQDPETHSSLEFNFGNAPGLYIGGTFFPVQPSRENAHNHELYLRTPSAQKPRAPLKLFGSVIGKFRVERQLDEKVEESVRDRTLEAAKQRTERHTKYLDTPPDLSYSNSKTGTKKKTGAASRVSVQAKSYPVSKPSPLPSRDVHTAASSSSLSAADQQTRERIIHFLALEPRTMSKTLDACCGKDRTEEQERKYEALIRQVAEPMPVKKGDTGGPPLWHLQRESWREVRPYTFPKLSEEERLGLSRQARLVFKALQIPESDPIWNNVRHRIASGAASGSAGPSAPAPEKNGVVMTKNSTKKAKGEGTRKRPLDIAIPSKDESGSAKAKSRDVDEGSAAGTPMSASRPTMGRRLPGSGFKVKPSPTPPTERRTHSPLPPPPKKAGPVDARESKRSAPEPSGSAKPLPPIAPPQTQESRSASVSAAAAKIRKKEAQSSAGTSRAAESRREERERERERVRERDHAAEEKLRVKEKERASPLPILPASAPLPSFKRKKPPQDGNDSEYSEREPSLSASSSKKRKLDAEPPSSTEKARSRDLSLPKKPVVREPSPLAPPRQKIKTEPSPLSSSFSPPRPSLPPKPVGAEKHQTSSSSSSVKSAKATEAVAPSRPSGKSKRRSPIYTSSSQDESETSVPVSRPRTAVPTAHRDSPSAEPPAKRRRLSKVHVPRFKPRPLPSDLASLRKYYRSCYSTYLDLYGEQTKRRNRIQRMLKRLEGEQGEESAPSDEDMEDLVPEVLKAFMDNIDAVVQEMKKVSNEIERLGGKVENGTPVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6H7</accession>
    <name>A0A4V2K6H7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-P-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1043144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6H7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="281" mass="31598" checksum="39129D2151502082" modified="2019-07-31" version="1">MSSEKPLVLVLGATGKTGQSIVRGLLRSEEFRIAALIRPSSLSKPATEQLRTSGIDIRAGDITDDYESLKKTLQGVDTLSSSVFALLIEQQKDIFRAAKELGVKRVVPCDFGSPGARGVRVLHDMKLAMRDFAKDLGVPYTFIDVGWWMQYYLPLPLRSTIPEAKKQKNWQIYGPGDKPILVTNVEHVGEYVAQIITDKRTAREIGERVSGDSDALEAKRVHLNPEDITRWTAEGRAHVGARIRSLEDYSKHLQYDYHYSMHVLHESTLENAKRLGYLDPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7U5</accession>
    <name>A0A4V2K7U5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_968188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7U5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="193"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="35279" checksum="858AC1D6C3FEA3EC" modified="2019-07-31" version="1">MSGTISEDNTTGSSVEFPCQFPDEIFKPSRDAIDGVLRLLGKTLKPLGEELWSRNTFYDLGDGRMAKFGPTVKIYEARAMHFVRCYTSIQVPDLYMVFEHDDQTYIVMELVDGISLRDASHTTNADGSPNYGLGPGLVADDEVLTIIEDLKNIVEELRELGRRFPPKNPWFGAWPEGPLSNCYTWEAVPAAPFKNIDEFHAYFLERLRPRCPDPSTYEALEQVRREAQDHAPVLTHGDLAPRNILVKGGRVVSVVDWETFGWYPDFWERMTIENEDLGSRIRQAVTTVFGEKPFEAKVYLYVDACLSLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K809</accession>
    <name>A0A4V2K809_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_820160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K809"/>
    <dbReference type="STRING" id="114155.A0A4V2K809"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="449" mass="49702" checksum="1B3B74C3716706B6" modified="2019-07-31" version="1">MGYLGFIFGSSTWTTTKHDVEVDLTTRYAPKRPIIRQPKPPSIPVPMEIVMTILESAYDDQEVVAYNALLKNAALVCKSWSNVAQKLLFRHVTLSTQTAYIAFQGAVDRTTARGRMLGDSVVRMKVVLDQKQPYRLSHRSFARAVSLCPNLYELGVALFGEGAPGLDIIGLPDESRMKRSVPSFDETTLAILRAGPQISALQFSNWSDNSDSLLQLLDVWPSLASLDISGTTPRLPNETVAPFPCALRELRTNFQASPSVEFMRWLLHNSRESLRVLDLARQPAPDMLDFLATEHGPTLESLALPTCGTHEGAVSVLKCTALRELKMESAWAAPMLLRGLPHGLQHLAFGVGADTALQHIVQAIKKSDELRVVTMQVWHGGERHPYLPNLRIACALKGVELRQTNDMPAFRVMTRGDPVPSASYPRTRSINNVLYMASRAMTKTSTTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8G5</accession>
    <name>A0A4V2K8G5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_366219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8G5"/>
    <dbReference type="STRING" id="114155.A0A4V2K8G5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="610"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="649" mass="70306" checksum="01EF39FB1FD40F79" modified="2019-07-31" version="1">MAAAVFLHNAIFAAEPPSPPPAIAGPHHHHHHHHRRSPNRRLPHDRQLSSVSSITLHASASEHSHPTESLMRPSESADAESTAYLDLLARQPTHPDSAVGHHERANALSLRGDPFSLRERRVAHEKLVRRRLKRLRLAQRVLWVVIGGWATYNTVRYYISAVLRPNRERQIIALVLGSCTALCLACNLLSVVITVSAAHLGWYYRPRSRLILLKCFLHYCSSISLLAPAFVNVVLTFLWRHSPDIDNSIRGRCHWEIDLVWSGYGGQCQDSPAWGFWLTGSLVRLILTAGVLATYHAVSYQYMVTRRPSRRRHTSSIFRHSAASFPSHSTATTASSRSFRPLSTTSVSTVPVSSPLAAGSHTSLPRNSSGNADDAGPRTLRTASSRIMAGDLASSGASKVIRRPSAKGLRNTAAQQDAAMRAASPSSSEGADTDEDGEDRYGRPVQRRVGGYVAVPLGSPPPRDDGSSWDPVPDSDLNDFATQFRSLVEEVTRATNDAASHPDSNRYSFPASYNEGRDRDRSDAHVVVGRTIHRMPTIESLGSHEVMSLASKGGFSTRNSTRSNTLSTADAPTSRSASRANSLDAAVSLSVSVDGPTVLGMAGEMSELVQTPSSATSTGGPVFFGSRSTSASFHTARSASAHTDDPEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8V9</accession>
    <name>A0A4V2K8V9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_813268</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8V9"/>
    <dbReference type="STRING" id="114155.A0A4V2K8V9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041033947" description="Hydrophobin" evidence="6">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="134" mass="14370" checksum="F63F88326241F595" modified="2019-07-31" version="1" fragment="single">SRLNAFAFVALPILTPATPLERSTETARSCCATTMRSGMSVRSRRNVTPSISKELGILLVVVQKIDTLIGLTCSTIIVVSVSSSGSRSANAVCREENSHIDTCVRCHVQTVTYAYIFPFAQDGTDCLGCVPVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8Y6</accession>
    <name>A0A4V2K8Y6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_919914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8Y6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7578" checksum="ACD4929D711C64DD" modified="2019-07-31" version="1">MATRYDTATNRNRGMDRDHSGNSWFWWDTDGMNLSCHWHAYHAAVELPGSEPLTQQGGRRFRHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K964</accession>
    <name>A0A4V2K964_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CFA20 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_810080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K964"/>
    <dbReference type="STRING" id="114155.A0A4V2K964"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040441">
        <property type="entry name" value="CFA20/CFAP20DC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007714">
        <property type="entry name" value="CFA20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12458">
        <property type="entry name" value="ORF PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05018">
        <property type="entry name" value="CFA20_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CFA20" evidence="2">
        <location>
            <begin position="74"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="271" mass="29473" checksum="0DEAB696BB3BA560" modified="2019-07-31" version="1">MFSSSVQPSLVSLFSSTGSDPLGLLKTHTDSTLPSDSVICLLNDTTSQPVPPPPQNLITATGLEDDTAPSPNYTLDQTVLHLQSPTLRTTYIRCPPAAPAAPGKAGSRAHLGLKHAWMHLQVRSMGREWAFEVGVVDRSGREGAVRCSTFQKQPKLKLQNLPLLLLPLSFPPSSSRPLTLWSTNSLNLPSLLPHFSSGALARADEDDEEPSAFSPTSHHNGGRTQVPSGTLSHVSYVKVYATCRLRRIWFSEGGPQQRLPWEFQLYAADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9X6</accession>
    <name>A0A4V2K9X6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_802947</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9X6"/>
    <dbReference type="STRING" id="114155.A0A4V2K9X6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="572"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="611"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="743"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="165"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1006"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1009"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1043" mass="111100" checksum="3767127BDD2EFA16" modified="2019-07-31" version="1">MPSREIIEQITPGEAVEYVLPLLNGLAMDEDEAVKEALAAELVPIIWWFITHCRLVEDDPPAPPSPPAPTPLSSVAPSADESISILPHLLTPRPESNTGAQDVPASSGDGSILVHEHEHDYDAPTVVPVQAFTPILGTLLLSPNGIVGGSARYAVVELLRRLRRADEREQPSEAESETAESLHPQQPSRPVSPALSQASYQDSAESLDLGLFQENERRLFERELVYQVVIGMGRLDMDDHRNDHEQEDFPDTPSEWDASTAVPTPQAIAFTSEPESYFPPAPALGMSFAGSSALPAPSPLVSTVDTTAVGTTTLSPAPSPSPPVLSTSPMEESPGHSSASTPSLTSSTSSSSGDYSDTVEPSEPDRFSLGLTSMLSASDDGSGGDELASTPSGPKMPFAMTQEAHWTTPGALPRPAALPTTPPFEVPPPPPVASPVPVSAESTMPLSSIPTLMVQAPSASPLRESPPRQQILSSGWLSPGSAARELAALEEQQHMDEGADLSEEAAVGRLSSMSLMAAVTASGSIGEDTKRAFVAEVERVGRDSVYWVRREASFAVGALAKVVPVEVVTSSLLPLFESLCHDATWHVRHSVLFALPAILSRLTPERRRTLALEVIVPLSQDEEATVRSAVLEALGEVIYTFADDEDGPPEALLNLFLGARTTDDPPGSVPLPDVERDVTPREVQATPLRSATSTSATSSAWSDYGTDAGGGPDIYDDPQRPLICAFNYPAVALTLGQRRWPELRSLYLSLAKDPSLKIRKTLAASLGEIAKIIGEEHAAADLMSVFWSSLHAAEGEVRTKIVEALPAFVRALAHPQRVEVVRGLEEAFSSGKLSSWRERERAVKALDGVVEVEGVDSGVLQTMLVKALDDRVAAVREAAVSVLPVFLRAWKHSPTLVEALVADIRAFAGSDSFRRRMTYVTCVQEMVVSDHGDVTVRGETFWETLSALVRDPIVDVRIRVARLLGLISDKLGGGDSDVAAKTVALARDLAQDSSHEVQAFATAVLAGSPASQSEPSRQPVATVSPPVGRSAATFSRPPPPSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2KA03</accession>
    <name>A0A4V2KA03_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_912253</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2KA03"/>
    <dbReference type="OMA" id="GHEIAFL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020666503" description="DUF7918 domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7918" evidence="3">
        <location>
            <begin position="27"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU65868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="354" mass="39532" checksum="721329E506597E47" modified="2019-07-31" version="1">MLGRLFPFFQAALLVLQDMPVHAGFFVHIRSEGERLREYGVEKKDANGYTSIISCYIASESGKTFEVYWHEPASKTDMLVKVEMDGQLTDEVAHFEYEGTGVSQGVIEYAQRAVRLYRFEDVKTTDDDSVARPGRVSAKLGTITVSLFLVSRWDESKARGSLKRPRMNPKSVVNPGYIHEKDKKEGRHNVCFGPREAMSSYSTSFQVYNPIGQHKRPIMVFVFNYRPRAILENKGYVPPSAHAIGAGRKRPSTSAVPHASKRPRKHSPEVIVISDSEDSEKSSESSDSSEGEEDTLGPESEEDVQETPVVGRMSEDDTEDIELAVGHEIAFLQAQIAKLQKELAEKSAALKAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2KA07</accession>
    <name>A0A4V2KA07_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat shock protein 30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_32404</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2KA07"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="326" mass="34958" checksum="9604741E2C6A3F0B" modified="2019-07-31" version="1">MPNTFTRGSLGQNPPNADRHISSGGSDWAWAVFAIMLICDLVALFWTFRRARGTRLFHHIAVIVLTTATIAWFSMASDLGATPIAAEFHRSNTNTRQIWYVRYIQYFITFPLLLLELLLATGLSFSDVFTTLFMAWVVVVTALVGALVRSTYKWGYFALGLGALCYIWYVLLGHAPASFAAGGVMRKGYRGGAFYLSFLLLIYPIAWGVCEGSNTVSPTGEFIFYGILDLLAGPVFLFGFLSQIRGIDYGTFGFTSMKYSEGMYNGHGVGTGTGTGMAGRTTGPVNGFGGANNVNSAPGTGGNVNTVGNGTGSTGLNHTGNTSTVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MW73</accession>
    <name>A0A4V6MW73_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin-remodeling ATPase INO80</fullName>
            <ecNumber evidence="4">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_794578</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the INO80 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The DBINO region is involved in binding to DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="4"/>
    <dbReference type="EMBL" id="ML145243">
        <property type="protein sequence ID" value="TBU52629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MW73"/>
    <dbReference type="STRING" id="114155.A0A4V6MW73"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF2">
        <property type="entry name" value="CHROMATIN-REMODELING ATPASE INO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="74" mass="8463" checksum="623D35929CBFC15E" modified="2019-07-31" version="1" fragment="single">DSARSLMNLVMQFRKVCNHPELFERADAVAPFLFSDFGRSGPLNREGDFVQLPYSTRNPIEYTIPRLFLENGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWM5</accession>
    <name>A0A4V6MWM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">GMC oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_888448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145228">
        <property type="protein sequence ID" value="TBU53003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWM5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="592"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="23"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU53003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="617" mass="67490" checksum="9EEF467F0196A924" modified="2019-07-31" version="1">MPVVSYEELASRSLDYLIVGGGTSGLALAARLSENEDITIAVLEAGEHHAPAPEIDIPGYIGRALGNPKYDWSFTCVPQPNANNRTVRQPRGKGLGGTSLINFTGMFRPSKAEVDALESVLEIEGWNWDTMLHYMKKSETLQPTKLSHADAIKFAADPDPKNHGTNGPIKKSFGPTFYELHAALYDSVQTFGVPRNPDTGSGKNDGSVMSFLSIDATTAKRSHAANAYLEPNLGRKNLLVLTGAHVTKVILKQDGPLQKAIGVEFVKDGTTNRLENVRRDVVLAAGSFQTPQLLELSGIGNPDILVQHGIDVKIDLPGVGENLQDHIGMTTMAELDIDEPTLDDLTNPEFARAQEELYKQGKGFLATIPAQAFVFLSADALGSPEDVAQWRAHADTHCTNTLAKVLPSLRSGLEKQYAVHRQLFDDKEQPQAELLMFTGYQRMLTAPPAKPGARYLSLVCALSRPLSRGTVHIASANPLAPPRIDPNYFGNEADLDLYVHVLQYTLKVLETEPLKRFVKEQIMPRPETLAKGREGLVEYIRENCRQVYHPVGTAAMMLREDGGVVDSKLTVYGTRNLRVVDLSVLPMEFVCHTQSVAYAIGEQAADILKSELLGSHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWZ4</accession>
    <name>A0A4V6MWZ4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ino eighty subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_804798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWZ4"/>
    <dbReference type="STRING" id="114155.A0A4V6MWZ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038014">
        <property type="entry name" value="Ies1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37287:SF1">
        <property type="entry name" value="INO EIGHTY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="66375" checksum="8CAD5BA8032238FC" modified="2019-07-31" version="1">MWRKQRLAKVASISSFPILPLSLGSNGHYAASRVRITPVSRSIKLTISLYRSQSQHKRNLAVKRQDGEPLTRVDLQYDMLNAIFNDKHAVFTDPHTTIRGDPAGTLVTFRDLYVNALIHSPKCSKASRDKIRESPEFGNEFAMISLLSNVGRINTTMAFFPEMKTALRTYHPVPALQRTNGNLQDAPRIKNILKSCFIPGEEQGMYSTPSDVLARSRSRKIPPTSIVNLIFVFSSHSPTIARSHFPPRAGVDFLDLFTPVRISSQSRARAFLWLCYHYHEAPSPNPFSDANSEDFPDRVPPLIRLTDAEAQAENIDSAEEHQRGFDMTDLRKRFLETQARGEYSRDPDLDLTRPQAGEPTGRGKGKGKDLVQTGSGSRIREASPADSQYSALYPLRDEDILEGPGRPLLRRLPSPQPHHSPDRRHLASPLQRHSLHGHLGTSSFPRAVADPYPRRPPSPSAELSQSSNGKPLRTQLRKHRGHASHAPLFLHEPYQYAPRIPRPALVPPKHAPTSPDTPKRTMLEQAWHVSMTSDPLLDSDDEVFADENTRLDYVLRLRIISRLRGKEPTPPRDVAPYGVNAVNPIVVPLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MB69</accession>
    <name>A0A4Q9MB69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RabGAP/TBC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_812742</name>
        <name evidence="3" type="ORF">BD311DRAFT_671603</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143478">
        <property type="protein sequence ID" value="TBU24510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MB69"/>
    <dbReference type="STRING" id="114155.A0A4Q9MB69"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000037">
        <property type="entry name" value="TBC1 domain family member 22A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000001">
        <property type="entry name" value="TBC1 domain family member 22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="101"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU24510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="397" mass="45718" checksum="E53166885E711063" modified="2019-07-31" version="1">MVIGEMDSEADERAGALGGKPRYDQGVVRDDAQEIVDDPLRLIDPKPGRSSSTSRVDSQPGDSEKLMREHSIRTNRRRKFVECITREDVDIAQLRKLAWNGVPDELRPLVWPLLLGYLPLPKPTRASTLARKRREYSSLVETTFMRGRDGLDQQIWHQIEIDVPRTRPGVRLWMQESTQRSLERILYVWAIRHPASGYVQGINDLATPFFQVFLSAYIDSDPEEFDTALLSDSVRMAVEADTFWCLSRLLDGIQDNYIAGQPGIQRSVKRMAELVARIDAPLAAHLDAENVEFMQFAFRWMNCLLMREISVQNTIRMWDTYLAEGTDAFSQFHLYVCSAFLVRWSKKLQEMDFQGIIMFLQSLPTQGWTDHEVEMLLSEAFVHYSTWHNAQSHFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MPF2</accession>
    <name>A0A4Q9MPF2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_976091</name>
        <name evidence="1" type="ORF">BD311DRAFT_778521</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143425">
        <property type="protein sequence ID" value="TBU28071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MPF2"/>
    <dbReference type="OrthoDB" id="3251587at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="36676" checksum="690688246E92368F" modified="2019-07-31" version="1">MSTLVVNDVGTELSYIDSGVPSGTKDYVTIFAIHGTVFTGPIWNRVISLAPKSGVRFVAVNRRDYPGSTALSPEEINVLNSGTDDQKADFLKARGVEIATFISLFAEKHNLPAASADGTAGGFGIVGWSLGCAFALAAVAAVDALPVPAQALWKAGARALILQEPPTVSLGKAIPPDAWTPLVDQSMPAEARTAFFSHWITSYFKHGDLSSRDPKAISYVVPATSRAPTIYSLTEEEVKHSIYEPSAFGSDMAFMIFSALQIAATYKKAVFDRDLRALVPNLKVTVFSGDATASFSIPSQWEVEDDDKAAGGGFVTVKWIPGFNHLAHVDEPAATLQVYKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N272</accession>
    <name>A0A4Q9N272_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_769778</name>
        <name evidence="4" type="ORF">BD310DRAFT_774445</name>
        <name evidence="2" type="ORF">BD311DRAFT_621176</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 5">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N272"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="188" mass="19989" checksum="9B3AD3DBE33E5088" modified="2019-07-31" version="1" fragment="single">MATTHNRHTLCTCPTCIQLDPIGQWIPTTTALHHDLMARRVASQAYQRGRGRGTATGSRARGATLRGTRNPLRGGRGALPARSGADSHNSRGQASVPMKRARAQSPLNTPPTDEALDPSTNPFDELGPIDVDCSMDGVVSQVDVEGSQDMTTNLPHSADSDSPADDAQTRPPTSCIPAQISDERAQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N5B4</accession>
    <name>A0A4Q9N5B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_913912</name>
        <name evidence="10" type="ORF">BD311DRAFT_745777</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N5B4"/>
    <dbReference type="STRING" id="114155.A0A4Q9N5B4"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF10">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="8">
        <location>
            <begin position="36"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="9">
        <location>
            <begin position="288"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU35217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="411" mass="43867" checksum="6125D5C34566BE2A" modified="2019-07-31" version="1">MLARLTARCPVRSLTRGYATQLRGRAEILAKRPDDVVVTFAKRTAMGRAKKGQFKDVPVDELLHALFKATFEKTKLSPALLEDICVGTCHPPSPLYVSRAAAIAAGIPVEVPISTVNRLCSSGLQSIVNISNAIRGGQIELGIAVGMESMSLNPRPTPEIVPAIGEKPQAHDCVQPMGWTSEMVARAYNVPRQKQDEYALISHTRASKAVSEGIFAEEILPVEIRGTVISVDDTVRPGVTLESLAKLKPAFLEDGASTAGNSSGVGDGAALCILTTRARAEKEGWDVVGKYVTSAFVGVEPRYMGISPAVAIPKILAQTGLSKEDIDVWEINEAFASQFAYCVEQLQIPIEKINPNGGSIALTHPLGMTGTRQVVTGLAELRRRNAPLLCTSMCIGSGMGGAAIFVNEARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N5G3</accession>
    <name>A0A4Q9N5G3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_836788</name>
        <name evidence="17" type="ORF">BD311DRAFT_680563</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
            <strain evidence="17">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N5G3"/>
    <dbReference type="STRING" id="114155.A0A4Q9N5G3"/>
    <dbReference type="OMA" id="ARDIKHM"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="363"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="576"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="17"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="738"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU35849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU65698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="759" mass="84167" checksum="4FA26E6D92B7B5D1" modified="2019-07-31" version="1">MAARAEPLSIESLLQKQREEKEAAAKPKFLTKEQRAQLAIQKRAQEIKEQREKEERAKRDREALEREAEEIRARERERERASRYGGGGGRNDDRYDRDRDRDRGDRYGRRGDRDRRPPPHEDRRGGTGGGGGSSLQGVPTGPRADRGKATPTGPASSSTSSMPPPPPPSGASNGSSSSVLAEASQSYDPPITSNDLDAIRSRYLGVDKKKRKIRKMNDRKFVFDWDEQDDTYNAETPAAIGSQRQGAQIGFGRGHIAGMDDAGGAVVPGRKSGAEGMVLADPLERRRAARTGIDERHWSEKSLDEMKERDWRIFREDFSIAARGGQIPYPIRSWRESAIPVEILDIVDQIGYKEPSPIQRQAIPIGLQNRDIIGIAETGSGKTAAFVIPMLAFISKLPPFTDDIRHLGPYALILAPTRELAQQIESETKKFAGPLGFTSVSIVGGRSVEEQQFNLRSGAEIIIATPGRLKDVIERHVIVLSQCRYVVMDEADRMVNLGFEADLTFILDKLPSDTMEGEDQGEQMDIDGETMIKKGRNRVTTLFSATMPPPVERLAKKYLKKPAIITIGEAGKAVDTVEQRVEFVSGDEKKKQRMLEILNSGQFASPIIVFVNQKKTADMVAKDLQRAGWNAATLHSGKNQEQREAALQSLRTGDADLLVATDLAGRGIDVQDVTLVINYQMANTIEAYVHRIGRTGRAGKQGTAITFLSNDDEEVMYDLKQEISKSPVSKVPIELAKHEAAQHKVSREMKRKRDADDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N7Z8</accession>
    <name>A0A4Q9N7Z8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_1008171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145358">
        <property type="protein sequence ID" value="TBU51226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N7Z8"/>
    <dbReference type="STRING" id="114155.A0A4Q9N7Z8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU51226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="600" mass="67157" checksum="37B6FAE2E46F7B04" modified="2019-07-31" version="1">MSRDNSFSDSDGRSLIPDLEEGLATSPTYAGPPATRPRNNKTNASAEKKYPQHHQLKHSYTSPTPAPLTTPQQRQQQQPIFLTPTVRFRSAVRKIIAMRSMSSLLARRGVGAEPGADPRSAAAFLKYGHIRQRCTIEVNDYSTTRAGSARMDNGEFLKFLGEEGERGASGAREPWVRVRWIDVGGISWDVIGALALKYDLHPLALGDVLHQRGHPRSKADYDPQHLFVRILVHTLASSASSSFFSDDRTPEDTSPADMFASMPRSESPAQMDDEEETDLKRRMSVHARANEESDEADERTVFGTSVFFSLRRSPKARGTKKKVSIGLPWAHPRARDVKGSPRTPGEWPFVAMGAAGIRIGESIKKARYQKLVGDRVDVQIHPMCVFLPRDGTVVSMHNDTRLALTAPMAERLRQRDTVLRTSADPTLLVQSLLDLVIDQALEVVEEYQGRILEIEEQVLLKPSMKTVRKPVHILQGDLVLHKRMLEPVKTLISGLRRYDADRALALRDPDDADVYDHMECILASMDMVAGITENLMNYTFNMASYEMNQVMRRLMTVTVICLPLTLLTGYLGNFMGTSMARMISIDFLTWTIALCLPWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N916</accession>
    <name>A0A4Q9N916_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_114189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N916"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="6"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="180"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="532" mass="59342" checksum="65041ABE6AC13006" modified="2019-07-31" version="1">MLYPTSQKIRNVCAQARVDGFRWLWTDTCCIDKTNSVELSEAMASMYRWYECASNCYALLDDVPSVEVEDPRHPTSSFRRSRWHRRGWTLQELIAPCSVIFLSKGWKVIGNKHTLADLIEEVTGIDRYVLTHERRVEDCSVACRMSWAAGRETRRVEDEAYCLMGIFGVYMPILYGEGRNAFLRLQEEIVKKTSDQSIFAWGTILDDYRLGAGAIPASAKERDSVPQSTSETLLASSPADFAGCAGISPISQQSFYERIGITATFPSPYTRSCHGIRTKFPLISIAHTSSGFATLALLACQDKQGRIIALFLRPPSCPTTSNTSHVGGYIAEAGHRTQYYRGTRIFISERSGLAIAAKLCLPFGKYARLLARPEVKKMYVHSHDTIPRIGTPNTAATSSSPSRTSMISFECCYTSVCSSRSSERSRRVDCVLPEITEKCLRLDVLGDSEMISFLGDESFTVYVGACSPDVLSPDPPQKAMFPATFPFDSELIPFFKMCRRLARRRTKENGMSSPRSQCACNGARTGDVRSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB75</accession>
    <name>A0A4Q9NB75_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_890996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145357">
        <property type="protein sequence ID" value="TBU51234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB75"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="466" mass="50096" checksum="AA59A0C1C3B3EE16" modified="2019-07-31" version="1">MSQRARWTMDGPPGSAFHELVVVPTLAPQLLRDGQVPEMPAAEGVPEGSNQAADTAANSAEAVAPPAGSVAPQIDTRLSRTFFIHVTTCYTTTIKNGRAEKREKHETSKSTTSAHPVLAVTRSAFITAALSAHLLQDRYDANVPNGPPMKVFWSGSPGGKTHAPVVQTDAEWQALQLQLGMVKASVGTVQVVFNLDGMSPWAKLKRPLSPSLHEEHGEITYGTAVPNVAAYSTEQTARKDAAKLIEKAWKCVVHQGICYIAPSLEHIQIHDVRLAQWSSAVVGGRPATDAPPEQLVALWSQKPSAVKARGRTGPHPAGAQPTAEVAGSAGDSGATVILTALLPLLTTVFERGLAQTAKPVAPVSDVAAAAPRSLHLASSPPPEVNEELTRCLEAFARERRIPFQLIDDAIMTLSDHSYTPDAIASVPIERLQELLPDFAEGQLYALKRYTDEWYSRIVTKRSRRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEA1</accession>
    <name>A0A4Q9NEA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_977954</name>
        <name evidence="6" type="ORF">BD311DRAFT_710799</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU33973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEA1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NEA1"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU33973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU57649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="304" mass="33496" checksum="9035BA421C6D4B18" modified="2019-07-31" version="1">MRFRATIENVDTFVKIVQSVEKLQRKCIIKFGEREMRIICTGDANEGGIQVWSTIKVSSLFTEYRVQSNSNNEITISVFTESLLSALHSAAASSSKNSSFLASDSEVIMKLAKNPEKKSVLSFEIKGTTSMGSNALIHKQLLIDVLRHADVDRLKEPLCPEPDVHILLPPLGKLRTVVERLRSLAAEGIHFRANHSGELQLSTSTENARLEVGWSGLTNPPMSRNPDGTQNTDESEVKDPAEMFGVLVSHKCLTKFLTCHVISSTTIACICANHCMILYVYIGNVADAGGVLTFYIPAQFDEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NES6</accession>
    <name>A0A4Q9NES6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Small secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_814903</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NES6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="16695" checksum="A0B0AF08C025556B" modified="2019-07-31" version="1">MALTSLFYGLLLTAITSAGAARATDITQVNAIVGVNGNSTVECWTLTTDISITSSASVEQLGSIDSASYSYFPGPDPFDSGTHTAPNLQYFFIIGGGGTITFPADPSETLSVKPGQLYIAVDSASTSDLGHHTVINGGSLVLQLPFSGGTIPSHTATSGQCASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NFB9</accession>
    <name>A0A4Q9NFB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_890399</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145287">
        <property type="protein sequence ID" value="TBU51768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NFB9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NFB9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="446"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="460"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU51768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="708" mass="78117" checksum="813B3AE3015F4B57" modified="2019-07-31" version="1">MYSPPSLLLVLLAPAAVTLYFLWTFLMLVLRQARSPLRHLPGPPSPSFFMGNLREMHDQENNGLVARWAAAYGSTFVYRGFIGGCRLMTVDPLAVNHIMSRGYEYPKPDFVRDALASMAAGYEGLLTAEGDMHRKQRKILNPAFSAAQIRSLTPIFWEKAIRLRDIWLDITASPKAFFTPVDPFARTEAPPSPGTADPEPAANAPLLSPSAVTTSFLPNPFAAFVPSKSSPTIPTVRARQPAGSCALELASDAPCRLDVLPWLARAALDVIGEAGFGYAFHSLEAAAERRDYESELAQAFGVIFGTARKFRVMTILQVWFPVLRRFKRENAAMQHAQATMRKIGTELIEQRRAAVAAESEAEKRSTIEGDKTVFDRDLLSVLVRSNISEVPGQRMSMNELLCQISTFLAAGHETSASALTWTLYALARCPSAQVKLRAELRSVPVPSGPSVPVSSPPPFQSSFPQQPSTPASVPSSPACSPPSSPTSAAAAHDAAMAALFDRISHLPYLDAVVREALRLYAPITTTMRVATQDDVIPVAAPYTDRRGRMCEEIRVRKGDIISVPIQAMNKGRETWGEDADVFRPERWEEARHREERCEEKGEKGRGKHVQGLWGNMLTFGGGNPVNGNRSCIGYRFALSEIKVFLFVLLRDIEFSNDSAVEIEKKVNVVTRPCVKSEPHRGNQMPLYIRRVLRSPSSDLRTDRHFGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHI2</accession>
    <name>A0A4Q9NHI2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_970297</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHI2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="478" mass="55665" checksum="4F5A1F9565F2A9E3" modified="2019-07-31" version="1">MAGFLKVDQTRIVDEEGKEVILRGAGLGGWMTMENFISGYPGCEFQIREALAEAIGQEKSEYFFDKFLEHFFAEPDAAFFKSLGLNCIRIAINYRHFEDDLNPRVLKQSGFKHLDRVVAACAKHGVYTILDMHTAPGGQNGGWHSDAGTHIANFWIHKDFQDRLVWLWTEIAKHYKDERWIAGYNPMNEPADPQHSGLVAFYDSVHAAIRSVDPNHILFLDGNTYATDFSGFPDDAGTRWTNTAYAIHDYSVYGFPDSPEPYARTDEQHRRMKRSYEKKRAWMDEKGLCVWNGEWGPVYARQEYEGDATDEINERRYNVLNDQLQLYAKDRLSWSIWLYKDIGFQGMVYVSPETAYRQHFRSFLEKKYRLAADSWGADDKHVRDIYRPIVRLIEDNVPNEEHRKLYPYPVWTVQGRVARLARCILIGEFLVREWTELFKGMSIEQLDLLAESFKFENCMKREGLNKVLREHAKQAQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NI91</accession>
    <name>A0A4Q9NI91_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_941823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145295">
        <property type="protein sequence ID" value="TBU51666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NI91"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17209" checksum="A5ABE3BCCBE81836" modified="2019-07-31" version="1">MLMLLLNLPCGMQRTLQMAYMTCFQAKSSGKTATFSSMVVVTFFDPGITRIGNLIQPLVSMMKWKTLPSGRRRTPHTTSSNRSTAAPTRRSCDGDFAHARSPHPNELFTILSLLRGKGSTNCVVSCHSPSPGEHSCTLIDAPPLKLCVDISAPPCLAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNB0</accession>
    <name>A0A4Q9NNB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_977579</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044325481" evidence="2">
        <location>
            <begin position="23"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="19643" checksum="05028E30B195A808" modified="2019-07-31" version="1">MFSKSFASLAVLSCMLLVGASPANIARADPSTMVASTTDGLQTTSTTTGSNSGIGPAATSTTVSESVTGTVSVETSATASTPAASTTAATSTMTGPADTSTNTAPGSASGSNPAAASAVTLSSIVGASQIFSSAISVIGTDPKVTAYITITLATAGSSTTVFAGHTLVADITNSKQGSGAAGLTISKGLLSGAVTIVGAVAVGAVVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNU1</accession>
    <name>A0A4Q9NNU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_844726</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9NNU1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="674"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="856"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1144"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1362"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="226"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="674"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="856"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1144"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1157"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1179"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1217"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1278"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1376"/>
            <end position="1388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1904" mass="205250" checksum="B85997C2C5C592DD" modified="2019-07-31" version="1">MDSTQPQAATSSSSPFLAHTEDSSQPGSSEPKVLRTSARVKAAKQKQNQRTQQDISQHAASSSSKRTRDNKGKGREAADEARAGKRTRRATLPASSALTINEPTKDAKGKKRAAPEDRSDDDENTATSSSAKKLRRATSAYSLRPRGDHQGTSDMTRKTRTTSGQGKVNTKSKAMLAAAGSSRAPDEDVEMMDAECVRDEGERHDEKHEDGDDHDEVVDEGGGGGNDDDDDEGEEADRDLASSLGAIGNEPSAMSIFGDYRQLGSYMMGISGRLKTMLNNIKPTADPTTRLLTLQELSELLSISTEDTLAGSFQVEAFIRELVRILGGTGNDEGDDDDDDAVEQDEDAALAAALAMSAGGGTYQGDENLEAQVLACRCLANLMEALPGVAHTVVYHGAIPVLCSKLIEISYIDLAEQTLSTLEKISEEFPSSIVREGGLAALLNYLDFFSIAVQRTALQAASNCCRNVSVEHFPMIRGVWPIIRNCLGYSDQRLVEYACLCVIRIIDSYYRSAPEHLEALVDADLIRAINMLLLPAGGSPLIASSTYTLLLRALATSARVSPKVTLVLLEAGIVDTLYQILTGVLPPSSDGVNEQGDAAGGQGLGGGLADMTVMENLAHRPKDQVEEALSLVSELMPPLPKDGVFDHKTYTEKALNKMIKAKAKAERAAARQAAAAQAASGSTSRPAAADTPASAAADEGQAPDAMSVDPQSVQDAEEALPQLQKEPATIDRTELLRSKPEVVGRFLRLMVPILVDVYAASVITPVRIKTLTGLLKAVSFLDGEELKQVFTFVPVASFASSILSSKDHPTLVIGALQLVELLLAKVPTEYKPVFRREGVFHEIEALASRTITSYKSKDKDKNTDKDISEAPSPGDTGIPTSVPIPIAVITSIPGYKKLSSLSIEPDDAITLRARVIRFKYLASDDSTGTDDVSANLRKLVERITDAAASEKDLATALGELAALFSSQHTSVSSFELLQSGVIDGLLDFFADSERTVPLSRRQELFFNAFTSRKTKGSGGQTPFAVFVKKLQESLTRMESFEVISVAQSSDDSKRSSPSLLARQLRLRLVASEDSDIPRNLSNIVVSIHAIATFQALHDYLRPRVSGLLSSSSRLSGMLAALAASGLAPPSARFGLPEPPRVSAAAEASSSASTAGVSRRRSLRLSAKKASTSGDSPADAPATEAASGGPGAEAAPSDVAEGESIASAAEPAPSETVVNDDEFGGDFTDDEVDVDAEVIEEDDDPDNSIADKTIDVSVSDDHKVEAQTPDGTLVATPGKAPSTSATPRTSTPKTSYAAVLKTKPSDWHLEFFMDDHKLPLDLTIYGAIHQHEMRKHKASGSPFVPSMIWQGVYSIKFKKVPGPPPLGDARADDNGSRSRSPVPSLSSLPEDAPHAKILRILRVLQKLNAQESERATAAAAKRILAPSAFVNNKLTAKLTRQLEEPMIVASSCLPDWALDLPLHFPFLFPFATRYNFLQSTSFGYARLILKWQSQQQSRGQDSSRRDDGVGFLGRLQRQKVRISRKHILESAVKVFELYGSSSSILEVEYFEEVGTGLGPTLEFYSLVSKEFARRDLKIWRDADSSIPGPHVHHPLGLFPAPISPDDIAKDGVQKRTHIIRVIGQFVAKAMLDSRIIDLSFNKIFLKLVLGEEVPLTIDNLKRVDPELAISLSKIQGLAAANSQNEKLRQKLAAIEGLEELNVDDLGLDFTVPGYDIELRPGGRDIAVTADNVDEYIREVINAIIGKGAQAQAQAFREGFSKVFPISDLQAFTADELAMLFGNADEDWSVETLSEALKADHGFNVESRAIRDLVEIMAGYDAPTRRSYLQFITGSPKLPIGGFKGLNPPLTVVRKPHEAPLTADDYLPSVMTCVNYLKLPEYSSKKVMSEKLLIAMREGLGSFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSA0</accession>
    <name>A0A4Q9NSA0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_936313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSA0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926:SF5">
        <property type="entry name" value="F-BOX AND LEUCINE-RICH REPEAT PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38926">
        <property type="entry name" value="F-BOX DOMAIN CONTAINING PROTEIN, EXPRESSED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="582" mass="65463" checksum="46A65B8159B732D7" modified="2019-07-31" version="1">MPAMHSSHSPSAEHLQWESVYDLWRLLRQSTHGRQDSWEEWEAALAASFMLEAPEDQVGPSSDSLVASPISRLPEELFMAIMLQIYDDGSTGPSWYKRFWRSLMLVCKTWRRAIITMPSLWRNVDISHEPRLLVLSVARSRGATLHLTIRSGGTMLVIAPLLSRLRSTIRKLMLHCVRSFDQSQCAFVRQLLSEEGGMPAVEELDLQFILDASESPWEPPKITFAPPIRLDQRLLPRLHTLRLTGVVLNTVTFIGLESMRLRHLDLTWCYADHPDSLLSFLTMLTAFESLETLQINSPVWDEACAPEDVVEERASEDLVLLPCSLRAFTITTDDHRLLLDWILPHVSLSEDVHAKLDAYKTDPEPAGEETPFTFRSMIPASCSLPALRSVQCVRLLVVTPPRWAPTWAGRVASPGLSGGVPPPANFKLLLSFSGRLEYWVQHGRFGLPTLVREVAELFGAAPVHTLELGGDVGSLRTDAWRTVLRAFPRLSSLMLSRWREEALLHWHRVPDDVVHLRLGLVALCEAMATAIGEHVLEEVVLRDKDVVCTLSLKDADGRYCTPTLRGVARNSALLDVTYYGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NST2</accession>
    <name>A0A4Q9NST2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_949895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NST2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="266" mass="29640" checksum="B19223E41EE3A9E3" modified="2019-07-31" version="1">MFSLRESFKALSRTIPTSRLPIPSTLHPLDSLRQPLRDNTETAKKLRMRVLRAIRAEGSIVKESRKAFKKAVRRREKVKAAEQGIAGTSLCPAPLPYTGAASFPPLQFLVLALLPSLKFGASLNRKEDHRHARDVPRTASSNGRISMEEIRPAPLEERMEKIMPTPLEEPMEDVVAAPLEVRTEEVVSAPLVYAPAMSHFFRRLIQQSERSSESAWPLPQPYVLPQTPRTNRTAARDIFALESPLSTRGWSPVSTLSDQATMAGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTU4</accession>
    <name>A0A4Q9NTU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_936309</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTU4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NTU4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="36442" checksum="92E5944D13CFAF9D" modified="2019-07-31" version="1">METLPLELHALIVEYACTDDGATARSLALVSRYVHDVATPFLFQSLAVSGLHQMTELVVRLEALPPRARRIRHLFLSDWTHKDVIKMQKQCAPTSFLEMERYDAERAFAGRILQHAAPTLETLALVVACPYTAPPLVGQLFALPLPRLQGLAIDGFYPFPHTRSVLPRLERLHLSGNRNPYGLLQLGALEAACPQLSYLRISGLDAAPAFARELHSALFPQPLSGGIELSSSFSFPSALPVRLRELRVEVCRPRECPVRQSHPTGRQRAHSQRAPHKSGHEKMMETLREVVRRRAETRLGNVEVVEGDREDTFGEMRREWLRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYF0</accession>
    <name>A0A4Q9NYF0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_948727</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYF0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NYF0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="14">
        <location>
            <begin position="306"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU58373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="598" mass="65764" checksum="22CB187903FD88D9" modified="2019-07-31" version="1">MTLRPREFKPTEADIQFKVAQQKAAVERMWMIIASILAFLFVVRLLRLTFSLLFLRRPAPTGEFDSTVEKLEKGSSPELVLPGRTGKASWRRIPAAIASGFRIIAFRVQVPLGVGGASFAELFFILGYIATMLALTFTNTMDASYWFFEDRGAHLASCQLPFIVALAGKNNLISLITGIGHEKLNILHRAAARTCLILLWVHALSRAISGLPPSHDFSHGWMRWGAVGLTAFTLLTILSVRFIRNALFEFFLLSHIALVGIFIVGGYLHARAVDYGDYFWPALVVWAFDRVLRTARLIWNNRGRGGTRHEYGSATVELVSSDTIRMTLRRKMNWRPGQHAYVVLPTVSGMPSEAHPFTIASIPQSLHGNDDNVEKDVVFLIRGRTGFTGRLREFASRNGVCRVPAFVDGPYGCPPDLTKFSTCILIAGGSGVSYTLPLLLDLVRRARTGTTHVRRVIFIWAVRESDHLSWISKSLCEASAAARSTSLAVEPTVYITGPTCTIPQIPGTAYDGSSTNSETGEVVDKELPVYSSLKIIHGKPSIRRILQEGVDGSSGPVSVDGACSLSGHCRGTLFAKTSVFCSIWSYVSHNVGVSRTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P4V4</accession>
    <name>A0A4Q9P4V4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_821194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P4V4"/>
    <dbReference type="OMA" id="GMHETVS"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="2">
        <location>
            <begin position="27"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="1">
        <location>
            <begin position="197"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="41352" checksum="C759FC58DA0E6C2A" modified="2019-07-31" version="1">MPATTLPSAPRWIPPPPTKKDLDWADLPIIDFSKASTPEGRAELAPRVCDVMRTVGFMCLVNHGLTKAQTDRFFDIGEVVFTQVSEDERMQHASKLAEEGSKIGYKPRALWTIDNGVRDQHEQYALHRTVFGGQKHPKALEPFLPELRAFCEHNHYNVLHNILRLLAIGMEIDEETFVKMHGFDAVGDSHGTFLYANYPRTAEEESKTNSVWLKGHTDTGTVTILYSQPIAALQILSPDGKWRWVKHIENALVVNIGESLEMLSGGFYKATIHRVVQPPMDQRGLVRLGAYYFALADDDVKLVPVKSPVLEEEGVVRKFEDDVAPTMGEWRKMRYMAYGLKKAIGTDKATQEQIVDNGVQILKYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7P8</accession>
    <name>A0A4Q9P7P8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Mediator of RNA polymerase II transcription subunit 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Mediator complex subunit 13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_813492</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 13 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9P7P8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009401">
        <property type="entry name" value="Med13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051139">
        <property type="entry name" value="Mediator_complx_sub13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021643">
        <property type="entry name" value="Mediator_Med13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48249:SF3">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06333">
        <property type="entry name" value="Med13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11597">
        <property type="entry name" value="Med13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="246"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="289"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="477"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="625"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="528"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="661"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1400" mass="150253" checksum="0AFCC81E01F06ED6" modified="2019-07-31" version="1">MRPTYYLPLGFSLPLPAGTPIVLLPQGVPAYYLSTYSGPTAALTTQFEEALRGLGAGDWMRATSPQQDGPSYIIAWLAVQNKQGEDKGMPIIWPATLCVAYHSSSPSAHARSTLPYIPELPSQLQASPPPPAAAVPASLSFAMAAPSPAADGSVSATTSQAPLPLTDREKLISSVSRRPSLLRSSPTSDSLRAFRTLSLAKKPYARDIKKVAGEVGRYVDSVLKERERERERIKRERQEQEIAIARAKLASANPPPKEETPVPPATNTPTTPAMPEEVAAPVAEPASLPMDVESTDPEPYPTVESDHSGDSLFSPPDAPIDLPSTDEEPQPAAEQLAPVDSDMPKEEDAPAPLLKTETDAEQPSMGFDPFNGFDSSWNQSNGYMDPVYPDMDFNMSLGSLGGGRATGVDADNYDMDDGFGVFTEDDFDFFDAPSTQRPVPSALVPPSAATSAAGAAVTNGMPSLGLAPLITLEGPLSGPGPPSASMAHSSPWVPHLGEPYSPQTTAEVHGLSDGLGPPPELLPPSPTKTPSSHSAPTTPSVHLSDTYRPNMLGPRIFDPIPFASSHREADGKYAIGKFALPSPPAEDRVEPLPAATTLLPGWKMNYSAATDPRIGVVRKLIGVKRKSLSQGTRANRRMSLWESDREPEDWQSGSPPPAGPDSEESEDELWVEDEEMTSAPRPSTPPPSYLPLGHGLLKTHFHHSHLLPMCTPLRPPGMAVNAVSGNAPPISVPTPVSPAAILGAASEKSKSLEAAAQILVKEVVENPVWQEAWRANASLSLTPPVPPAQIWQADAKYISQLVGNQSPGSAIDLQVLFGSAANHSEVTLMPLESPLLVVGKGESIIQVSPTSLRFWEKLGLSPRAGPKDVVAFVLFEEKKDEDREAEIETWLAKVSAAYSAKNFGSHAAGSSNVFIKPGLAPVRFNTLRKTICSFVQEITTPYSHLVLYIATPSHIISSSSTTLRQILSAVRRFYKQHPQGDILVQLVPESLIFGTHIHPGSSLGGLDAFVCSVYDRLLQPVKRAMSRELFIRGPPVTSYLEAPAFALVPYAAGKARNTAVVPRISFALESTASSLDVTHRHMLLHVGYQVSACGRWIIAACIDGEGEAHDLKVWLTPDENVEQFVVGQIWSFVTDFARRANIEWRIVVSKLGLISQTEANAWTSHLDSSMSSTSSAGPPLHATLLSVDIDNPWTFIAPADVNTLDVLKRNPSGGSQILVPKSSSRHMHTIFSDATCATYSLSPSTGYMYPAYLADRRTNSPSHLIPGSSECSFIPDVEDEDSPSSNPGSSTDPLRVLSWTMVICAPSSADHTSVSTMRIFLLHAAHSSRSTYGVGIAGDTARSRSRQLPPEHMSDIVRNFHELAVLSRAKWKLRADPVLPFHLAALEVMRAALAGGAVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P810</accession>
    <name>A0A4Q9P810_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_973181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P810"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="258"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="593" mass="64319" checksum="731F6E839A10973C" modified="2019-07-31" version="1">MPLSVGGGQLPVSAFFGSSANRSAKPQLKRRHSSPRQQAVPPKKRKQKENLTPSGSRNIGHVVAKTTGHDVGSSQPRPRRSTGTANEVDMGTARVEKEKPTLENGLNGPPSKADSGCAVIDLTDDRPGDIVPQPRPVYRLETPPLTPEGRGRRRDLGSIVSLPSPPLTAHDARKLRKRGNDSEKQEENVQKLHHALVHHDASPGAAGVKASMQASQSSGTPLQDQTIEHKDPCSLTRPTNDRDLMPPPPLPFKALLHSSPASSLTMPTLSSSPAYRPHPSSPIRWVPSSQTQELSIPRITGLPDRHSSDETRRGRRRSATQVVPSSQPDERELELPSGSSDHCDVHQLRACEARPGPNPLQANETDEGHAHDTSPGELIESSQSQFEVEITPAWAERIAARRAELCGSKQEQQAGGSSLSPSSPPRAAETQDYDAESEYSSSVDEVSQSSVSGQSGPRSSTPSQYRRFCEMFEGRDDDGNELPREDTASVRRSRSVSPTWDRGRDACERACSPLPSSSPSARSDRHIPREEATASPQAECAVDGESSYGSSFSESTPTAFREYWEMFSDSQTQDAPEYAPSQVQDDEGCVEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P898</accession>
    <name>A0A4Q9P898_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA photolyase, FAD-binding/Cryptochrome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1035164</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="4">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA photolyase class-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P898"/>
    <dbReference type="STRING" id="114155.A0A4Q9P898"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003904">
        <property type="term" value="F:deoxyribodipyrimidine photo-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032922">
        <property type="term" value="P:circadian regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043153">
        <property type="term" value="P:entrainment of circadian clock by photoperiod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.579.10">
        <property type="entry name" value="DNA Cyclobutane Dipyrimidine Photolyase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036134">
        <property type="entry name" value="Crypto/Photolyase_FAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036155">
        <property type="entry name" value="Crypto/Photolyase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005101">
        <property type="entry name" value="Cryptochr/Photolyase_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002081">
        <property type="entry name" value="Cryptochrome/DNA_photolyase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006050">
        <property type="entry name" value="DNA_photolyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455">
        <property type="entry name" value="CRYPTOCHROME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11455:SF18">
        <property type="entry name" value="SI:CH1073-390K14.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00875">
        <property type="entry name" value="DNA_photolyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03441">
        <property type="entry name" value="FAD_binding_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48173">
        <property type="entry name" value="Cryptochrome/photolyase FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52425">
        <property type="entry name" value="Cryptochrome/photolyase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51645">
        <property type="entry name" value="PHR_CRY_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="351"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="395"/>
            <end position="402"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="493"/>
            <end position="495"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="427"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <feature type="site" description="Electron transfer via tryptophanyl radical" evidence="5">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602081-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU63972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="588" mass="66483" checksum="F225CF4665DB9F36" modified="2019-07-31" version="1">MGKRARSLSSSPHLAPANGATKKKREVNFSPNRIATAEHAAKADASPPLFQLVDAVHRNVDNPPNGECVVYWMRMEDLRIRDNRAIAQASAQARKDSVPLIVLHVLSPQDYIAHDRSARKIDFVLRNLQIIRSRLSELDIPLYTVSHEPRTKIPAFIHGLLQQWKASHLFANMEYEVDELRRDIALSGIARKHGKVSCTFLHDRCIVPPGEVTTKDGRGYTVYSPFLRTWKSTIDQATSDYIGEAPLPVANDPAVRSHPVYSNLFDVEVPHEVEGFTLDPKVRERMASCWPAGEDAAHEVLRRFLETMSRTSHLGVTDPLSESAKMAKNPSTQSRLGKYNDQRDRVDADTTSRMSPYLAAGVISARTCVREALESCGKKKVDISRDTGVGRWIQEIAWRDFYNHILAFFPRVSMGRPFLEKYAHIQWETNEAHLQAWKDGRTGVPVVDAAMRQANTMGWMHNRGRMIAAMYLTKDLLIDWRLGERYFMEVLIDGDLASNNGGWQWSASTGVDPAPYFRIFNPYTQSQKIDPGGEYIRAFVPELAKVRGPEIHKPPPALADKLGYPRALVEHDMARKQAIERYKNIGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9N5</accession>
    <name>A0A4Q9P9N5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">(2E,6E)-farnesyl diphosphate synthase</fullName>
            <ecNumber evidence="6">2.5.1.1</ecNumber>
            <ecNumber evidence="5">2.5.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dimethylallyltranstransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Geranyltranstransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_942694</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.1" evidence="6"/>
    <dbReference type="EC" id="2.5.1.10" evidence="5"/>
    <dbReference type="EMBL" id="ML145388">
        <property type="protein sequence ID" value="TBU51128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9N5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9N5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU51128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="360" mass="41295" checksum="2330D475022C1421" modified="2019-07-31" version="1">MADAKAQKRQKFESIFPILRDELLGYLKQEGMPEDAITWFQRNLDYNVTGGKLNRGMSVVDSVEILKGRKLTDDEYFKAALLGWGVEFLQAYYLVSDDMMDQSITRRGQPCWYRVEGVNLLAINDAYLLEGSIYYLLKKHFRSEPYYVYLLDVFHDTTFQTDIGQLIDLITAPEDNVDLNKFSLDKHQKIVIFKTAYYSFYLPVALAMYMCGIPHSSTNDPYELAQKILVPLGEYFQVQDDFLDFAAPPEVLGKVGTDIIDNKCSWCVNTALEVATPAQRKVLDENYGVKDKAAEARVKALYEEIGIRERYAEYEEGAYKRIIGLIETIPTEGADVGAGDVKLKREVFKVFLDKIYKRQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBL6</accession>
    <name>A0A4Q9PBL6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_941320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145277">
        <property type="protein sequence ID" value="TBU51908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBL6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="5">
        <location>
            <begin position="56"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU51908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="235" mass="22765" checksum="E353964CD77828C3" modified="2019-07-31" version="1">MLASLPVHLLLLTFASYVSAAASLTPPPVSASDTSGSLSLSLTPTSSAKVSASGSGPSSASGNISSTATSSAQFPSLSGLSDCASQCFDLAIGQDNCTSVIQVNCYCANSTRFTSGLVDCISSSCSSSDLSPAESIAEQFCAQASTSTFLSFPTPPPSGSATSFSNPFSSSSAVGSSNSSSLSGSGSATVPPTSSATASASGSGNGTVRLSLPIQELMAAGVVGLGGALLGLLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCQ8</accession>
    <name>A0A4Q9PCQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec7 domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_983030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145453">
        <property type="protein sequence ID" value="TBU51007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCQ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PCQ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF373">
        <property type="entry name" value="PH AND SEC7 DOMAIN-CONTAINING PROTEIN C11E3.11C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="1">
        <location>
            <begin position="40"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="304" mass="33363" checksum="9CB735CA47783964" modified="2019-07-31" version="1">MVIDGLIATPACKVFGAGKDIRVLGQDAGNGQCTSAILLGLSAISQQDLTTNDILPARFSLGSSPRRQQEETADLAAPCWAEDEEFLPKDEIAEWLGGQSLINKTALRHYVNNFNFSNFRLHQAFRRLCAKLYLKAETQQVDRGVRAAVLEMQPVFRFGVCQYVCPTCLVHAVSYSVLLLNTNLHVAEPANRMSRNQFVWNTMNTIQLQLLPDEIASSTDLTYNGWRSIRSSSEPGDTVHAKAKRSDSITSWNSITWEALSPSIGTPVNFSGQLMLASTDPIRLSLANQSSVSVGTSSVADCYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEU4</accession>
    <name>A0A4Q9PEU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938412</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145219">
        <property type="protein sequence ID" value="TBU53268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEU4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7801" checksum="E0980BB5ECE2170A" modified="2019-07-31" version="1">MARYQPHFSCPLFSKGSVVSQTSQKNMNRKYVEDESFPRRLTLPSRHCVRGEECHRRSRGFEGELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEV3</accession>
    <name>A0A4Q9PEV3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_211332</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145241">
        <property type="protein sequence ID" value="TBU52665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEV3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="187" mass="20357" checksum="235D2A9074D74E0D" modified="2019-07-31" version="1">MGAIGPRRRTMLGSRPDSPSRGGFAPRHPWRRVPRRRSGSSCASWAAEASLLAWPRRGELRPPRPLGEWGVSPSGSVAGTRGRDGSLRSGWVRRRRRRSERCMPSGVRSALGTCGGNVACARIRDRGSRNADTCGGECRGVGGIVPENASCAVMCESYRDRSPLRHLRPQRTRAVQGVMIERQLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEX3</accession>
    <name>A0A4Q9PEX3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1042363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145212">
        <property type="protein sequence ID" value="TBU53500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEX3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020273710" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6083" checksum="4A71D58EDF8F573D" modified="2019-07-31" version="1">MKFGFNVFIVAAALVAHAAATPVKGLIPNYATTVTETFGGTTITLTETIDPPGSFPTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGC9</accession>
    <name>A0A4Q9PGC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_342839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145314">
        <property type="protein sequence ID" value="TBU51506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGC9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="2">
        <location>
            <begin position="314"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="835"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="850" mass="95386" checksum="EF010A79B42FC790" modified="2019-07-31" version="1">MAHYGVHAELLEFCDEFFPKPTPSCTTRPKPTLDGNPFAALRNAEKLLEKNVRAAFTAAVNVHGLAPGLKMAECGERPDPAAIDPERKKIDAAFYNVDDVPDDGRQRWADQILSVEFKRDDVSLDPFDDDEENICTPTLTRKAVRGQIISYAELIFAVQQRVALFTLVVLGTRVRFIRWDRSGTVVTRAFDYVQNWEVFCEILWRIGNCTMTQLGFDPSATRLYPGQAEYDLMDAAADNVEGDIDESERVVSEPDLPNGHFKYVREMFKKSLVDGWPRYMLEVPAPVEAATTATSATPARHSDSSPKVDRPVRKFLVCKPEFRAKGMAGRGTRGYVAVDCTTKQFVWLKDAWRANYKKVDQEGVMLGSLNSVEVPFVPTLLCHGDILQQKTATPDWWERKNPLRSPTSSASTATTSSSATASSHTLVGPSTSGSLKRKWVEEPCGAPSAPPQNTHGDSDEENDWRTDCPLRLHMHYRLAVKEVAMSLSKFKNDRQLVGIIYDCIRAHESAVKRAKLLHRDVSAGNILIYPTVMKTRGIYWLKWSGLLADWELSRAVHEPDTPRRPRQPERTGTWQFMSVALLSHGLKIVGVADELESFFHVMLYYAVRYLKVENCDLPTIANYLYTYFDLYGVDNGVYVCGDKKRQTIAEGRLTVSVNKKLEFGSPLDTLFSQLLLCFKARHVVLANEAEKSAKSPSKSKTQAPSNDIGALLVDEEMDLVNTDHSKWEKLLVVEAEPGLDHKTIALAEQLSKHETLLHVFRKAYVSDGWHGARVEDNIPDWWAPPTQAVVALTDTSAASNKRRKVGPPPPGINAQKFLSCPQLPLYPPTYPPVTPKKPRAPETTWNRRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH43</accession>
    <name>A0A4Q9PH43_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_831707</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145241">
        <property type="protein sequence ID" value="TBU52681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000630">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="884"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="923"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1033"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="257"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="597"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="888"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1224"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="821"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="822"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU52681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1489" mass="165490" checksum="0803C95923033D65" modified="2019-07-31" version="1">MDNPGGTGAERLPPESQPRDIHPFDRESRHSIESPSKTNAMFSIYDLVLTLDVLALLVLFAVTIPVVPPHFPSRERRIYPWLFYGARIAAFALVLGMMCLPRRWRTRFSIPRNIILLAIWAVYAYRDIWPLATYDLTPIDGAEGNLLWAKIGLLTLAAIVLPLISPRHTDDLDARPEQRASIFSLVTYGWLDPLIWRAQHLKHLPFEELPPLAEYNSTDHLVETSYALVDPMRVSDDRSKSRDVAWGLARLFSPDLLVMGIMVILASASSFLTPLGLKHILSHVEQGSQNETFKPWFWILALLFGSMGVSMCMQYYHYVSTQVVARTQAILTQLMYDVALMMRPKATTNAKTAPGKPQDGKGAMPLVQNLVTTDLTNVTNASTFVLLVLFETPIHIVLSVVFLYSILGWSTFVGVAVMVALFPVPTELSKRTKGLQGAKARASDRRVTLVIQMLDMIRTIKFLAWEPEQAEKLGNARLEELRAIRKVNMMQIWIGAINVCIPLLIMLASYATFTLGMKRELSASIVFSSISLFEILRSQLGLIFFRIPILTNGKVSLERINRFLKETELLDRYTKKGGNVDHLTENGHSLETHATDIGFRDAHFTWTEESAQDQPFTLKIDRELLFKKGGLNIIYGPTASGKTSLLVALLGEMHYRPQNGSSFVSLPVEEGVAYAAQESWVMAASVRDNILFGQPYDEDRYYHVIEACALDEDIDEFEHKDETLVGERGILLSGGQRARLTLARAVYSKAQILLLDDILSEIDNSTIQHIVRHVFRGDLLKGRTVILATNNVKAVLPIATWAVQLGHNGTVVDAGPPPQDLIASSATPSATPNGVHVKSSRADRKAGADQPVQQQQVAPEETQEGHVGWKPMSLLFGNMSKYPILFWIVLLSSLLLASVVINAQIWLLGYWASQYSDQPASRVSVVFFLAIYVTLLIGSLLTDAVSRMVHLAGTLEASAKIHSKLANSILGATLRWLDYTPKSRVVARFTDDIGASKYPNYCFVRVTSVNHPLVDGQISNFLLKLLELSTSMLVRLVLVLVVAPIFTVAVLLFGIISGIYARAYMKAQLPVKREQSKTRAPLIGHLNSTVASLVSIRAYGVQKTFQNDMHDRIDRWTRASNTFYNLNRWVIVRADLVGTIFTVSLATYLTYFTKLNASNIGFSLNMAIAFSSKVFEFVRTLNTFEVSVYSLERIQQYLVIEQEDMSEPDAIPQAEGDWPADGSLDVEDLSAWYTLDGPEILKRVTFSIKSGELIGIVGRTGSGKSTLTLALLRCIPTNIRTSSSPEATGDVVYSGKSIGMVGLRTLRKKITIIPQIPELFQGTIRQNLDPFGKYRDAELGSALLGAQGIENAQETVTDTLTLDTQVSSGGKNLSAGQRQIVALARAIVRKSKLLVMDEGTWIMNNESNAKIQLALRKQLDHKVTVITVAHRLSTIKDYDKVLVLDAGSVVEFDSPINLLRKENGRFRELVDQASAEERQLIRAAVGLVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIN5</accession>
    <name>A0A4Q9PIN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIN5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="13"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="37688" checksum="E4A27E476FD540C3" modified="2019-07-31" version="1">MSTQRALVVPAEGQPFKFVSDWPIPKPGPKDVLVKLVSIALNPADWRLELGGSGIFKDYPIAGGLDGSGAIEEVGSEVTHLAKGDKVLFEGWFVPGRGTFQEYALSPAAYVAKIPDNISFDRAATVPMCLATVFSSTWAHEDGARSARLTPPWEEGGKTKYAGDVAFIVGGSSSVGQYAIQGARLQGYAAIIATSSLKHQEFLKSLGATHIIDRNLPPGEIQAQVRTFAAGKPITYVYDAIGERDGQRLSYELLADGGAFVTVQPFFHEYLEDLVTESKPVIRALGSFELPGHGKLGLEVYSRLSEWLATGVIVPNRAEVVPGGFAGIPGGLERLRKGEVSGVKLVVHAAETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJ85</accession>
    <name>A0A4Q9PJ85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Permease for cytosine/purines, uracil, thiamine, allantoin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_936617</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJ85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU54150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="536" mass="59200" checksum="61F4F8216E8B6FF8" modified="2019-07-31" version="1">MEKIFTYTRREAWVLEPEPSTFAPNSRWSNKDMDPVPPKWRTWTTFNYIAYWVSDAANVAVWELASSMLAIGLSWRQALPAIAVGHIITSIVMVLNGMAGARLHVGFPVLNRSSFGFWFSYFSVVSRVVLSMFWFGVQTYTGSECVYQMLKAIWPSVAHLHNGLAPVANITTAGIMCYSLYWLIQFPLMFVSPQKIRWLFLVKASIVPPAWLAMLVWSFVKVPSSKGLFEQPSALSGSAISYAWLSALNSALSINTTIAVNISDFTRYAKNAQAQCVQLFIIPIAFTLVSFIGLAVTSAGVTLYGGAVLWDPLQLIDHWDNRAAAFFASFSFVIATLGTNISANSLSAANDMTVLFPRYINIRRGQVICAILGGWALCPWEILASAQGFLSFMNGYAVFLSPIAGIMIADVGYWIVHRGKVDVPSMYRPRGLYRYTYGINWRAVVAIMFSVPPNMPGLISSINPKIAVGSALKIYDFACIFGFAVALTVFSVLSFAFPATKTFLREAVTSEDLGEYSESERSSHIEKGVDSGILVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK66</accession>
    <name>A0A4Q9PK66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_987613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145187">
        <property type="protein sequence ID" value="TBU54502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK66"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="271" mass="30422" checksum="141CFC5BAA438466" modified="2019-07-31" version="1">MLAIGSNLLSSPYYTSSPARFAMTPTLVYLPSSIRKLCPSSLRQWCARKALLMSLVLRPSEHQVQRATLALLNRRRFRMSEDGYCILCVLRWHKRRRATKEAGTGSKARRNMVQGGSSHLVLKSAREWRPRLREVHEMKSSVISLGLSAYVHGLNSYRVIEQVPYNDGTRRQRDLCSITFNVALSQANEGNFRGADLPAFVYLACQALPEDLHIHVHLVGLRSSDLRQGVLLGGGCVTKGDLARRIAMEVTAILDTIKRSSQIQYEGRDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKK3</accession>
    <name>A0A4Q9PKK3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_64211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145184">
        <property type="protein sequence ID" value="TBU54635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKK3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU54635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="359" mass="40520" checksum="33631243D4997D9C" modified="2019-07-31" version="1">MLAIGTQFHTISAILATFPSLIPHIWLFCHVSAIVAYSLLPVISDVIAQGALETISDCCGIDIPLFLLLPSPGLMVVFFWNHSQHRRQDDLLSHTTPAQTSAEQRSWSTRELRNRTTSPTPRLRHDTLCDHPRMSIVVHPGPHKSPILAERNLEVLIAGFNLTGVQRNHQVSDLTAELAAARHTIASMTARTAALREEKDDALTRANTLENAKESWKMREKALLATIEDLEAYPTRFDDMRLQARLQETERMLAHEIALRASAEDELTRYRDVAQAQLEELRASEKENTRCVNEQAIEIAMLKAQLLAMQQFNLAALGTKPRRTVSTFPKFWKKRRDVKVDLGISSSTSSRTITYTLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKU1</accession>
    <name>A0A4Q9PKU1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal ATPase PEX1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Peroxin-1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_1041561</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="17">Interacts with PEX6; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKU1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKU1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19526">
        <property type="entry name" value="RecA-like_PEX1_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000105">
        <property type="entry name" value="PeRoXisome assembly factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015342">
        <property type="entry name" value="PEX1-N_C-lobe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF12">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09262">
        <property type="entry name" value="PEX-1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="198"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="284"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="913"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="966"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1030"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="987"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00064205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU54790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1052" mass="113832" checksum="A4DB61223E0084D8" modified="2019-07-31" version="1">MPRHCRIHFVSLHSSLVNLPISLYGPLVERGIRPQGLAVHLKLVSSNKTSFNSKDAAKKPEAYVGWTGLASSSSLAHFNSGNAGERGLETVEIDPQYAEGLGFASGDVVEIGLLHDLAYAKSVATEPATSDDWEILELHASHVESTLLSQVRVAVVGQEIDVWVLGRTRVRLNVVSLEPSTGKPLLLTSNTEVSIAPKLRSKQNAASEAKGDTGKALGVPHGSGQASPPEKSRAPRQARTLRLLPHRLFPNAPSSHPDTGFAYVSYKTLLSLYPQGVPSQLQGWRATSRRVAPPAGPDREAAPASPAPAPQARVLVPNGEASSSKGPKLIDESKNEVVVVWSPDVPVPDGHVVLYPVLDHAEDWDMIRLIFIKEDGGYPIPPYQRTSLMVPDKLNTSASHGLAGVEETFAKCTQFCLTSFALHAFNKRVRGVPGLLVTGRSGAGKTALLHAVSKAMQHDPRTLTYTLYVDLSRFNGSPVAKVRSQMKYWMDKVSWHKPSILILDNIDKLMGTELEHADSFHTRHVTELFLALYGFSARSAAPNASGVVLLAAAESQASLHPLLNSSHLFQEVVNLKPPSKDARKEVLAHLVKEHMDSSNIAQDPAAPLNYTALATQTEGYSVTDLKDLVARAVHRAAIRSSELQLSTHEEPQHTILTPADFSAAQVDFVPHSLRDVKLQKSDIAWADIGGLRETKQVLRETLEWPTKYGPIFAQSPLRLRSGLLLYGYPGCGKTLLASAVAKECGLNFISIKGPEILNKYIGASEKSVRDLFERASAAKPCVLFFDEFDSIAPKRGHDSTGVTDRVVNQMLTQMDGAEGLDGVYVLAATSRPDLIDFALLRPGRLDKSLLCDMPDAEEREEILSALGRKVAFARSVDLAALAGATEGFSGADLQALVYNAHLEVVHDTIAHPPAEAGAPSINGASSTAANENAERPVRYTVLGSESEGRVLSRAEESAFQRRLRRIVSGPSVDGRKDRASPSSRAGTDAKPKAKHEIKPEDLERVLKVTRPSVPPEERERLRRIYSAFVSDRSGDLPVPPEAGGIGMRASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PL71</accession>
    <name>A0A4Q9PL71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_766221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145180">
        <property type="protein sequence ID" value="TBU54865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PL71"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="12125" checksum="E4A0C57F50606785" modified="2019-07-31" version="1" fragment="single">MRHALDGLEHLVVPRLTGTSSYRAPNLRHLDFWSTSLEPGLTCQDAHNARAYVHVAVRRESTVPALRTVRFIFTLITRTLHGAYMVAHPDWPRICHPDLLRDLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLJ6</accession>
    <name>A0A4Q9PLJ6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_711851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLJ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12350" checksum="9B4F232A5572445C" modified="2019-07-31" version="1">MTWFAIGRRAGMKAVIKTPQGSLSSVMLRDGMIYFVADASGDHSHTPFGSIVTSINTSISVVMVSHFLLDLQEANQRTVKVILKILYILREALLVVRSISCVGWWIPWVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLP0</accession>
    <name>A0A4Q9PLP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_934533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLP0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006353">
        <property type="entry name" value="HAD-SF_hydro_IIA_CECR5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01456">
        <property type="entry name" value="CECR5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF4">
        <property type="entry name" value="CAT EYE SYNDROME CRITICAL REGION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="382" mass="42504" checksum="F0A5773B7DCC43FF" modified="2019-07-31" version="1">MIKRAPSMFVVRHALSSPSARCRSLRTHTSPVRYIQSSSRPRLPPLAFAFDIDGVLLRGPHTIPAARRALDMLNGVNPMGVTIPFILLTNGGGLGEEARRHKLSSQLGVEIHSNQIVQAHTILKSVVHKYADKPVLVLGGRNDEIRKVAEDYGFKHAYTTLDVLAWKPEVWPFHNLTPEERASVKPADFSGIPISAIFVFHDPRNWSLDIQVILDVIRSRGIVGGPYLDPSPTSNQQSLPPVELVLCNPDLLWKSDFPQPRLGQGAFREAFQAVYQAVVGARYPCVQYGKPTKATYEFAESVLRDRLEEFSGDRVDEMPRVYMIADNPESDIAGANAAGWPSVLVKTGVYDPSRGPPTHTPSYIAEDVEEAVRWAIEREMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMG1</accession>
    <name>A0A4Q9PMG1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_969276</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145169">
        <property type="protein sequence ID" value="TBU55423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMG1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMG1"/>
    <dbReference type="OMA" id="NEEAHYF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="222" mass="24370" checksum="2ECCA76248F6F25B" modified="2019-07-31" version="1">MGLIVRQVIKPSEDELGTYSKLLAEAFGYGFFGSALNNDKTLQEPMMSAHMNAALLENVGEVDIAELPEVGVVGVAVWFHPGHEYLDSEAQLNAGHNQVMAGLPVELQNWWKEFLETYGKLTDRVLGHGVKLGAYHLQLIGVSPVHQRKGVATELIRYIEAKACKDRVPCVLETVGKTNLSIYEAMGYLIKGTGTIKTPPPHTGKFEMAVLLKHTEEQGSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMK1</accession>
    <name>A0A4Q9PMK1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_950840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145170">
        <property type="protein sequence ID" value="TBU55386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMK1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMK1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="36"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="116" mass="12669" checksum="43BB3D3DA8ACBCDA" modified="2019-07-31" version="1">MARAADTSSPPSGDAASNSPQEPTSKRDSEYWLEDGNIVLTAGQTAFRLYKGLLSRQSGVFRDMFAAADPDVDATVEGCPALHLSDSPEDLRALLQTLVPTERRHVYLPDQQVHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMM4</accession>
    <name>A0A4Q9PMM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_681222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMM4"/>
    <dbReference type="OMA" id="PRCCANT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="192" mass="20310" checksum="3FDD37E53C1F7F1B" modified="2019-07-31" version="1">MFSGTVHKAQVAPQDRNLRTYRSIKSGRVRRRGSSGSHIPQSPARKHTNHPQPCSSSSPPRPPHSSSPSPPYHAPHPPRPAPSSPSRRALPSPGTSPCAPSTSPPSARPTLAPRAPHLPRPCATSSSARSSPPTFWCARRPAAGYAMSSAWRASPRTSASLPTSPGSPSRSCSPAARVCRSRSKSESQGARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMQ7</accession>
    <name>A0A4Q9PMQ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_777191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMQ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="133" mass="15460" checksum="2B195DBB1CD59DFD" modified="2019-07-31" version="1" fragment="single">VKTRWNTVAVVLERILELKDVLPELCDMHRFNGDRSARLRRYILSNEEWAVLEQLYRLLDPFLFATNDISLSTRGLVHEVIPYMDVLTAHLDDFQDDLSLTSAIRAAAKRGRLMLSKYYSLTDETPIFRIAMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN31</accession>
    <name>A0A4Q9PN31_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_960772</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN31"/>
    <dbReference type="STRING" id="114155.A0A4Q9PN31"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF4">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="48"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="325"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU55584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="503" mass="56277" checksum="0DDB972BCDF78B4D" modified="2019-07-31" version="1">MRTQYWARGDISRIVSRCEFLSYPPIPPDFDRAQSAFSVPPTERDPYQYQVGFGNRFASEAIPGTLPYAQNMPQKAKYDLYTESLNGTPFVTPRRENQSVFFYRIRPSVAHKGFTALPSNPDLESCFLPLNPNVHFSPTQLAWYPFDIPSNESKVDFVEGLKTVAGNGDPTLREGLAVHIFAGTESMGKRAFCNSDGDFLVLPQQGRLDIQTEHGKLMVRPGELVVIQRGMKFKVGFPDGPSRGYILEIFGSHFELPDLGPLGTHGLANTRDFESPVASFDIDQSPWEVVYKVGGKLYACKQEHTPFDVVAWHGNYVPYKYAMEKFVHVGSIQKDHIDPSIFCVLTAKSKTPGAPLADFLIFSGRWDVATGTFRPPYYHRNCASEIMGLIYGDYGGRSDEFAPGGLSFENSFCPHGVSYDEFKKATEVDLQPVRIHEGTLAFMFETSMQVTLTGYAMKRTGKLHEHEPKMWDDLKGQFVNHIEQINADLKAAGLPPLGTPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN99</accession>
    <name>A0A4Q9PN99_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_676645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN99"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="64" mass="6932" checksum="3CA3442D2DFD1BC2" modified="2019-07-31" version="1">MLAAFGDGGSRGVTTRPDNSRPETRVTRHPNACTRPGNSSFPDIGNRDIITIYGHEMPIACQAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPB4</accession>
    <name>A0A4Q9PPB4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_932095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPB4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="6932" checksum="4B704D0BE2C57F68" modified="2019-07-31" version="1">MTRILGYNSINGLSLCQPCPEPSLAKPPSLDAVSASPLYHPLQRTSSATCPLGSDVCESCQDGCSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PR11</accession>
    <name>A0A4Q9PR11_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_881838</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PR11"/>
    <dbReference type="STRING" id="114155.A0A4Q9PR11"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
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    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="19"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU56803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="123" mass="14076" checksum="213DD1FC75F4CB80" modified="2019-07-31" version="1">MSPTSDTRSQVITTYLDRPTFSCAKCTAVIALQDELISKAFSGRDGRGLYLMHSAVNLKMGKKEDRPLLTGVHTVADVYCMGCNERMGWYYHRASDNSQKYKEGKYLLEREKLAKENKWKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRA7</accession>
    <name>A0A4Q9PRA7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_930529</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRA7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7470" checksum="3364DDEAB19C9F83" modified="2019-07-31" version="1">MNGRSRNYKHSVKGQILAGENMRRMCGFPRHSLHILPHVLQDGESVDYMHVASTFSPCSLVLDSVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT51</accession>
    <name>A0A4Q9PT51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT51"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="174" mass="19412" checksum="D58CADEE4D7200C7" modified="2019-07-31" version="1">MTDTGAALLAHLNKGSTIGVGFLGVIASSIVYGVTCMQTFQYYRSPRAKTDNRPLFYMVLVLWILDSLQSSFSIYACYFYVIDNYANPSGLLINIWSIPAVILTNACISFLVKTFFTFRVWRLSGSVYATGTCVIFNLARLATNIYYPARTFSFASLLVAEVELEVCHDFSNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTW3</accession>
    <name>A0A4Q9PTW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_949164</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU57869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="472" mass="54453" checksum="411D1B73AD8B6E1A" modified="2019-07-31" version="1">MFSLMRGATPVIVINKAQIAWDLLQKRGEIYSSRPRLIIAHELLSRGLRGLTMPYTKQWRTWRKVSQLRCYSAPAIQNTGLNVRAALAYLEHQTLEATIALRDFLRAPEQFATSVAFSIAYGQRTATLEDEKYRRNGEAPCFDCMFTWFRRTTFADMTSEALLQYPWLMYLPRFMQWFRFRWDEGYGKAEMLYMELLKDVEDRLKTGIAKECMATRSLRDQEALGISDVQLAFAMAAPFAAGIDTAISRFLWSTLASRRNTPQSKCTMRGVHEELDRVVGRNRLPTFDDQASLPCLDTFVKELNRWQTITPRGVPHALAADDVYQGHFIPKGTIIVPNVYTMMKDEETFPDAMRFSPEGFLKTDDPRMLDFTLSFGFGRRICPGMHVALQSLYFFFRQRWWRPRRFMWAFTVKPAQDETGATVLPDMNNQVVSGLTRKPAPFKCVIQPRFPDVAGMIHKEAAEADETLKAWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUC3</accession>
    <name>A0A4Q9PUC3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_851805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUC3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUC3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="236" mass="26648" checksum="EDBD77265DBDEF24" modified="2019-07-31" version="1">MSSAPRWVEAINKALGHPDNNGKMIYQIATVDTNGQPRVRSQVHRGFMEPDGHPELPVLVTSTDARTPKVGQLHSHQRTELAWWMEGSQDQFRISGITHIFPSPAQGAPGNGPTPIADEAIALKLLQNSGFDWEAKRKETFDGMKPGMRASWAIPYPPGTFLPSYDEQKKWPKEVPLEQDAKTDEDKKNIDFAFRNFALMLFEPVQVDWVALGVHPNQRIKFTRDEGVWIEQQVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUM4</accession>
    <name>A0A4Q9PUM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_927744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUM4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUM4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005303">
        <property type="entry name" value="MOCOS_middle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF19">
        <property type="entry name" value="MITOCHONDRIAL AMIDOXIME REDUCING COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03476">
        <property type="entry name" value="MOSC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="MOSC" evidence="2">
        <location>
            <begin position="229"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="427" mass="47605" checksum="F5A37516145C41E9" modified="2019-07-31" version="1">MAISLYDLVDHWFAQSPTSRAWTVSAILVSLTGILWGLFGRSPVCGKSGAVANGKAPVCPPEQLKDDLATLKDGNGVVNAYTLDREISVPFDVGDVRVSKILVHPIKSCRGISAREWRYTPEGLEHDRKWCIIQQQSRAIITAREVAKMVLITPRIEIDPASPYGGRLFISFPEDSGCETFSVPLYLTEDLLKTWPVIDDCTMFNVYRVQGYVCSSLDCGRSPSDILSQYFEQPVHLMMKGPRVRECPTTLAYPDLKASAMFQDGYPFLVASEESLQEVGRVISAYATHESPEAQIGQLDRERWRDGDIKIERFRPNIVLQGSGVPFAEDMWRQLVIRQRDSSEDEESRTFSLVSKCTRCLLPNVDTVTGTRDAAVPYKVLLKFRRNRDPARMSKPCFGCNAVVGGEGVVSIGDRVEVKEWATGIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV27</accession>
    <name>A0A4Q9PV27_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_926994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV27"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029208">
        <property type="entry name" value="COX14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14880">
        <property type="entry name" value="COX14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9095" checksum="6B114AC2071D8965" modified="2019-07-31" version="1">MAFRTRLSIGDVLHRGVVWSLFGITVWGAVMIGVVHRNTLAAGRGALAKQQAETPAPQTSSEEQNEIALAEAAQAALKGRSGQRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PV96</accession>
    <name>A0A4Q9PV96_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">PI31 proteasome regulator N-terminal-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_977381</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PV96"/>
    <dbReference type="STRING" id="114155.A0A4Q9PV96"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="173"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU58376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="341" mass="36344" checksum="E0B4C5F12663C701" modified="2019-07-31" version="1">MTANVLDASALLQTLPTILPPGKKKLESQQDAIAALVHTVLTVLGFRLTGVDESAPTRTFENNVFPEEWNQHGPGHYTLKYRHEQSSLDFLVKVTKLGSRTLVNSIAVETDKVASLDIPTNDFTSPSFFPHELSESSSPLVHGFISSNRVDDLISQLRLTTVQKLIPGLRKEGYTETVTETETRAGPSQPRAPQPDAPPARPRPDEPPLPPGRSPAGFPYPRNPLEIGRRDLDPFPSNPFAPPPLFGSNGGGGMFVGPDHPIFGAGIRDPGPGGMGPWGGDGYLPPLGAPPGARFDPIGPAFGPGVPFPGRMPPGGRGGPFGGQDPDNDELPPPGSRDMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVJ0</accession>
    <name>A0A4Q9PVJ0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_1039135</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVJ0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVJ0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017177">
        <property type="term" value="C:glucosidase II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06603">
        <property type="entry name" value="GH31_GANC_GANAB_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033403">
        <property type="entry name" value="DUF5110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17137">
        <property type="entry name" value="DUF5110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020619282" description="Glucosidase II subunit alpha" evidence="11">
        <location>
            <begin position="19"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="13">
        <location>
            <begin position="85"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="12">
        <location>
            <begin position="375"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="15">
        <location>
            <begin position="718"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5110" evidence="14">
        <location>
            <begin position="829"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU58479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="979" mass="109825" checksum="742DA8CFA9477919" modified="2019-07-31" version="1">MRAFRSLLVLAAVPAALAFKSQDFKTCSQSGFCRRGRALSARASESPSWRSPYSVDASSIALSSDQASFIAAVKSSIYPDVKFSLDVRIHDDGVVRVRMDEVDGLRKHYDEAASWALLDEPKVSQQVQWKVGKDGVSAVYGAKKDVEVKVAFEPLKVTLLRNGKEQVVLNNRGLLHMEHFRTKESVAKGKEGIAVPEEGLDIDDDAQVVLGAHPRTAWFEGEQEDSWWEETFNSFTDPKPRGPESLSVDIDFPNHGHVYGIPQHATRLDLPTTTGENAHYSDPYRLYNADVFEYLADSTTSLYGSIPFMHAHSADSTVAIFNAVGSDTFIDIGHPTAKSSTSHWISETGILDVFIFPGPTPADVFAQYTRLTGTPALPAHWALGYHQCRWNYVSSDDVRTVQKRFDEEDIPVDVFWLDIEYSEEHKYFIWDRKHFPDPVDMIKDVEAIGRHMVVIVDPHLKRTNDYPVYKQATELGILVKKGDGTTDYEGWCWSGSSAWVDFFNPGSWDWWKSLFKTESQGEQWSWVDSTVDTGIWNDMNEPSIFNGPEISMPRENIHYGGWEHRDLHNINGMLFHNLTSQAAMARTDPPKRPFVLTRSFYAGSQRFGAMWTGDNLGTWEHMAVGVKMVLANNIAGFSFAGSDVGGFFGNPEPEMLVRWYGVGIFSPFFRAHAHIDTKRREPFLLDEPYKGIVRDMLRLRYAMLPVWYTAFREASVTGLPVVRPHFVVFPQDENGFSLDDQFFVGGSGLLVKPVTRKGATEETVYLPAEDQVYYDYFNDYAYRSTSSKGKEITVSAELHQIPLFIRGGSIIPTRERPRRSSPLMKRDPFTLRVALSSDGSARGELYLDDGETFSHQQGQFVWREFAAEKPTKKSKGVRISSRDLAAQKPAEAVDHVALTTYDSSNAFAKDIADVRVEKIVVLGLPAKPSSVTIESGKELRWTYTPGVASSDKKGGTASVLVIRDPKLAITGDWSILVQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWM8</accession>
    <name>A0A4Q9PWM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_439724</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="18104" checksum="831A2E8002BDC4C2" modified="2019-07-31" version="1">MICIQPAIQLNNSSRILGSGRSSGNPRATARGCAVWTTASSEPSVLICADVSLDRRIPRLQWPHGLIVIPMSTNHRCFLILRRQLTRHAKDSDITPRYFHQVDTHSMSVVPRFRWTSSQRPADTWTPDTQSNAIPAPILRLLMICFDVAIGALLYVICEAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY10</accession>
    <name>A0A4Q9PY10_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_817397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145114">
        <property type="protein sequence ID" value="TBU59440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY10"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="333" mass="37249" checksum="B30B353C71213F4C" modified="2019-07-31" version="1">MSFDCFSVEVAELVVDQLSDDVPSLRNVALVCHELLPRARFHPFVHIGVRNRDQMHTLREFLDNAPYICPLVRCVTISTTDDEPHSFTILETIPVPLLTRLPNLRRWKVTNQALDFNGQHWLSLSQSTLASLRKYTAMIGHLSINTLSFSGCADLVRAFADQVQIRRDVSEAAVVSLLEISKSSLQELAIHVTREQAGSVLGGQLSNLNTLTLCMPVEGRRVAFLQAISRIASFFKLLSGVGTVRLQELRVHCYGSSFSALAAILAQEGTLEACKQLEQVLLAFPRHALKFSLAESGRRSRSFQEDPKNSELKEHFPTLWSQGKVTVELPMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYT4</accession>
    <name>A0A4Q9PYT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_368473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYT4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYT4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="21072" checksum="53A904BD185E16FD" modified="2019-07-31" version="1">MLHKSPRNRASLKDLRDDYRCIATGAIYTQYYRAHRGEIGEHNSSIKLLRCCRIFPGLTNSSLHKIVCTVLEGPGFTQLVEELAKENISTALKNVFMVESVDLCDCFDTLELWFEPVTGVPNRYRFASIHPLEAIGIRKEFITFHSSNPRLPSPSSEYLSIHAACCRIAHLSGASDHLYELEEHCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYT7</accession>
    <name>A0A4Q9PYT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_947914</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYT7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="83" mass="9065" checksum="54E2D0DDF7B48FA8" modified="2019-07-31" version="1">MPMIVCSVPMARCALSPSAAVPSATPYPHQNAEPYLRLFHCDVPHAQCSGCYVCASTIRRARMVLLEGVRVQKGNSKPTQHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYY9</accession>
    <name>A0A4Q9PYY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Elongation factor 1-gamma</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_976162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PYY9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PYY9"/>
    <dbReference type="OMA" id="TQYFSWT"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="420" mass="47132" checksum="0C091CA1B510976D" modified="2019-07-31" version="1">MSSIGTLWTTPQQGKGKIIRAAAALGGLQVDLPEHYVHFEDNKKPEFLAKFPHGKIPAFEGKDGFKLFEGSAIARYVASLAPNSNLLGTSTKEAALVDQWVSFADSEIGSFTGVIFGLVNGRITPYTKPVHTHFAERQLRSLKTLDTILATRTFLVNERISLADLTVAAEIQRAMNVTIDAPIRAQIPNVIRHVETIVNQPQLKEIYGELQYLEKALAFTPPPKEKKEAKPAAAPAPKAEKKKKEEEEEEEDDIPKEEPKAKNPLDSLPKSSFNLEDWKRAYSNKDTRGPDGALEWFYQNYDPEGFSVWRVDFKYNNELTQTFMSSNQIGGFFNRLEASRKYLFGSMGVLGETNNSIISGVLIARGQDIKPVVDVAPDWESYEYKRLDLNNPEDKAFFEAALAWDLEVDGKKWVDGKNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZZ8</accession>
    <name>A0A4Q9PZZ8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_815285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZZ8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZZ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="115"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="265"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="624"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="539"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="626"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU60413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="808" mass="87220" checksum="2C1AD44942E072E5" modified="2019-07-31" version="1">MASEYSSPPPEPRHQPHPYLHEPLLYISNLPAFVRDEDLAVAFQTCAPFRPNIQRDGSNRPLSGTIEFKYLEKAEKALATLQGRPIPNLPQNVPLVLSPYPSTTPPTPLPPPNASPRLVKQLPLGYTDSQLYDLFRPFGALASVRTQAPFGKDTGVVEFWREEDAREAEDTMHCAEVEGQNIVVQVYQPRRAGAVASEFSPNAPSFIPTGSVFPYPAQYSPPRQSPYGGPRQQQPLFIHGPGQQVQLAPLSGPGSTSHSGLIDPCNLFIKNLDTSIDSNGLFSHFRQFGQIVSARVMRNEQGESRGFGFVSYQTPDQAAAAMNAMNGVTLGTKQLVVRLHEPKQLRQEKLAQRFGGHNGHPRSSSGATSPTASEAGESYAGWPSPSSHPAVLGSPVMGHHDRPDNRARRSSGSFYHAALAGTLNLPMRYDDLSALSPVVRKEVLSGELQRQIKGMDAVSSDELESVVQAIVGLSLSEVVQGIQDPAKLSEQVQAAKKSLNLSKGSSPAPPSPSPAASQDSRLLDIGPNATASAPDHPSTPLSMPATLSTPPRTESPSGSLTTPQSERDRMFAAVSKLESSQVSDLTDLLMSLPKRERAMCLFNVEVLRAKIADAKLVLEVDETEEQTPAVQTVPVPQTPQQRKVSAASFDSPHTPDLSSRGPSAAASPTPATPSSQVHTIASLARLPASEIIKLVQSSSVTGLPLPKADPMVVKATDEFIDSLQDKPINQQKQQLGDKLCAMSFLWYVCFANCVCRWRVVKAFGIKGAPKITIALLDQDDLRPLAHLMNSYPSVLKEKALLVQAAQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q106</accession>
    <name>A0A4Q9Q106_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q106"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7647" checksum="9807A496D4DA78CE" modified="2019-07-31" version="1">MSTSWLLRLSIPSFSFSTLDSERARETVKRLLDTLRISLPMVLECEDCDSDDSTRGASSAGVCVGYEGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1F0</accession>
    <name>A0A4Q9Q1F0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_771310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1F0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1F0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="12206" checksum="631743A7EDD1E3EC" modified="2019-07-31" version="1" fragment="single">MAVPVRAACSHNWYDEPIRKHTIQDDMESMLYVILYCGPVCGILYLPHYTPDMHMKRALETMFDYYSDVPGAEFPDGGVHKDANIQSRKYTQCLAWHSSDFKSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1F7</accession>
    <name>A0A4Q9Q1F7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_921945</name>
        <name evidence="8" type="ORF">BD311DRAFT_754087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MOZART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143404">
        <property type="protein sequence ID" value="TBU30624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145101">
        <property type="protein sequence ID" value="TBU61012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1F7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1F7"/>
    <dbReference type="OMA" id="LSICVGM"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU30624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8125" checksum="B37727DFB80CEB9F" modified="2019-07-31" version="1">MSTREADRISAAEETLNTLFDMSQLLNTGLDKETLATCVSLIESGVNPEALAAVIQELRRESTALKNSRTATNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3S0</accession>
    <name>A0A4Q9Q3S0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial FAD carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_921063</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3S0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q3S0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU61254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="36261" checksum="011FA83D34B0B77B" modified="2019-07-31" version="1">MSTTQQPQPSFFPTSAIDHAFAGLGAGVVAVLCMHPLDLLKVKFQVATEKPQGGIGRAIWSSLKGIHAQDGLRGLYRGVGSNVAGNASSWGFYFLFYHMLKQRASGGDPNYKLSPGAYLLCSAQASAVTAIMTNPIWVVKVRMFTTKPSDPTAYRSLWHGLSSVWRNEGVAGLYRGTTLALVGVSNGAIQFMAYEEMKRWGFERKRLQFTKAGKEYTAADDKLSNTAYTLMSGASKLFALTSTYPYQVVRSRIQNNLTSHLYPTIPTCIKKTWAEEGLRGFYRGLGTNLVRVLPGTCVTFVVYENLAWLLRTSAVKRERRKQLATAEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q418</accession>
    <name>A0A4Q9Q418_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_974617</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q418"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q418"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="8">
        <location>
            <begin position="480"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1060" mass="117143" checksum="C2ECE6B1AF466C8B" modified="2019-07-31" version="1">MSAAASVLQNGNPAETHGNFDLVKRFKVDFADIHVSKWKSRESGLSVVHLDYDAPLVNGYFVVGTEIFDDSGCPHTLEHLVFMGSKKYPYKGIIDHFANRGFSNGTNAWTDTDHTAYTVSTAGEQGFLQLLPIYVDHILYPTLTKAGFITEVHHINGKGEDSGVVYSEMQGRENTSGDLMVLRMQRLLNPPGSAYRSETGGLMEALRVLTVEQIRKYHGTYYVPHNLTLIVTGKLASGTTSLLDVVQKEVEPSIVEHKQNRGPKPEGWKRPFVETASAQRNPIPETVKETVEFPEKDESVGELQIGFLGPPPTAFLERKALDILGLYLTSSPVAPLNKEYVEIENPLCTYIYFSEDTRAKRVDLPVYIGSVPTEHLDTFDEKFKASLKRIADEGVDMDRMAMVINRDERQLRSKIESSQGDTFSGNVITDFLYGSEDGSDLAPSMDEINYYAQLKKWSSTQWADLLRKYYVDPPSVVVRGRPSGEMADRLDREEKARVAAQKERLGPKGLAACEKALEDAKKEHEKEIPPEILKSFPVPDVKSIVWIPVQSVQEKHGRDGRAPTVQGDNSQLAKHIEQDGTPLPFFVQYDHVKSDFVTVHAYFSLAKLPDRLRPLMSTYLSSFFSLPVKRSNGERLNHEEVVHKLDSDTVSYEVALGVNSTFTETVRVSIKVETSLYDSAIGWLKDLVYGSEFDKERLQVTVAKIAQSLPEMKRDGDTVLGSVSAELLYAESSTSRMGGVVPQMEFIPKLAQQLQESPPEVVKDLEEIRSYLTDPTGVRISVNGDILSLKEPRSAWARHFGKALPESELASLRLAVDTLSPVGKNPVKRAVVVSLPTIESAFATHTAKAVQGWSHPEYPAMRVAIEVLNATESYLWRYIRGSGLAYGAHCGLDLEAGFVSFTLYRSSNSIEAFKQAASVIKGLTDGSIALDETVLDAAKSSIVFGVAKSVSTPGRAALMSFINQGLKGVPQNHNIDLLEKFQKITKDDVLAVLKKYFLPLFDSSSSVAVVVTAPGKADEVSEELSKVGFEVEQKTLQVEVDEDGEYSDSDSSGSESDGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q480</accession>
    <name>A0A4Q9Q480_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_920583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q480"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q480"/>
    <dbReference type="OMA" id="MEEWHED"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="657" mass="74686" checksum="D34C56E352E735E7" modified="2019-07-31" version="1">MQADESSTQAVAQSRNTGHTTCEAKSIHGSGALVYLGSRRHLRGRRGGLKDMPEMPLDVLFEIFGFLHSRDLLSLARATREFRALLMSRQSAPFWREARRLIEDLPDPPSYLSEPAYANLLFSVHCHNCCKPNVQAVYWTFSVRYCDPCQKAMFADETEVSAFLMEAFQYASDLYVNSRYDTGRSFGRQYHIPEIGAVRRQWAALRDDAERARFKADRAAFVAESQKYCKLLSLWQVSCKGKRSKEVCELKRERFEAVKCRLHQEGFGDVLSCMKYMELTGLKRMSSVNRASKLTDKGWKSIRTSVVQYMTPIHDRYLKARTELTYRLRLGRLRDLLDDYHHSNTPRTPSSDCEPGFCELATLPAIQTLLQDMSSDVVQELQILPVDFPSLMISWTEHHRNVFVELALRGLGESSASLELDTLLDLALVSFVCKRCHRRQLRWPHLLSHRCFRDRSEVHPKSVYEVLASHQMQSDHDAPYRGEELAVFDDHVAVTHSIISLCGLAPDTATYKDVEDAGATLVCWLCMSESPGQCQVFDWQTAIRHSIISHSTEGADPASFWERLLPVQTVQAHALERTLVQQNNTLSQNPINVFGCTRCPSHGSVVVLMFHFLCVHGLVSPELGEDMYLHEDSKPCGAPSVWIDLSARRLCTEVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q589</accession>
    <name>A0A4Q9Q589_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_145781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q589"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23367" checksum="FC5F29DEB9845CAB" modified="2019-07-31" version="1">MGVEWHRQPPSRSCSLLFVSVSRGSLILADITVLATTWWTTYRRGARGMFFGKRTLSYVMLVNGTGYFLVMLALHIAHLSLTLVGYSNPDGINTSMITAFAEPISSVLISRFLLDLQETSERTLYLDTRSRQGYSTTSDAGSGTLSFARVIGSIGGSIGYGESAKEGESTVNEASRGTIWTMAEGDPDYTDLQRVPHGPDSTEILDLTRRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5R1</accession>
    <name>A0A4Q9Q5R1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF8040 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_810115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5R1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058353">
        <property type="entry name" value="DUF8040"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26138">
        <property type="entry name" value="DUF8040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8040" evidence="1">
        <location>
            <begin position="7"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="52" mass="6030" checksum="821F1321C5A9DB69" modified="2019-07-31" version="1" fragment="single">NPEPYHTSFLSGRQWVQDLLNDHRNRMKDSLGTPAAVFRRLEEELIHAGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q655</accession>
    <name>A0A4Q9Q655_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ARM repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_918562</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q655"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q655"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13394">
        <property type="entry name" value="Syo1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="430"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="376"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="687" mass="74585" checksum="0B8D96086E268453" modified="2019-07-31" version="1">MGKSQKKRNMRRHNPMRVPDSHLPKGLASAAATSSKNEAILPIIQKLESVDPSERKWACVAVSNIIQNDPSTRRLLQGKNIVGALITRLSDSEEEVVVEAAGSLRNLCVDGGFDICAEMYNKNILAPLKIYVPKISATLSQYLESPKNAPENAQKLVYEFAENVITILWCLSETSNKALNAINQISLVPFLMSFLAARDRLPLSTVTSAAQCLYVLTDENYPIIDEVRSNAGYTACLLAIIRSAEEAPKTNGKGKETFDVGADALRVLSCGILRNISPIPPPSIATTIDIDRDVVLPTLEPVLSSIDLQEASQAAQHAVDNQESTPQLENLSLKHTPKSDHKTPSELELERLETRLRTIQLALEILTGMCATLPDPEMFSGATDADGEDDNEAGDEDVDDAPDIDMTIDNADASPDTPGDAPQPPAFFTTLVAPLLKLVQPTPLSFPPLDNPSPHPPTTSALGAIHVSALECLNNIFLSMATSLAGRPSGLAPENGRTVFDAVWRALNAVGTDISRSGQERRREVWNMGVGVLWGVGNVWKGALVPTEEHVQVLTQFCGATADTGVKVKTIGALECLAQHPESVDANRVISAYLLSLLPPSANPPTPTEPLLQAVSALIDIYSDETLPYDVNFRSGRYLDALVQSVEGVRKAVRGIDRKKERELRVRGEEVRDNLVAFIQYRRGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6W2</accession>
    <name>A0A4Q9Q6W2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_698990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6W2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020703719" evidence="1">
        <location>
            <begin position="20"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="14146" checksum="8B666356F4863AA4" modified="2019-07-31" version="1">MVTASTLVAHLHWILSVQGHSILPMLSGSSPQRPLYMKRRMFRIAIVMRSKRLASGMQYLDMNVSSLVVVQSGSMLYRVGAVKSPRCLQSSAPMAHTSLPLLYLKANRCNCLGLNNQTRAVLCMVANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q776</accession>
    <name>A0A4Q9Q776_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD synthase</fullName>
            <ecNumber evidence="2">2.7.7.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">FAD pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FMN adenylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_841331</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>FMN + ATP + H(+) = FAD + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.2" evidence="2"/>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q776"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q776"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23948">
        <property type="entry name" value="FAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293:SF9">
        <property type="entry name" value="FAD SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23293">
        <property type="entry name" value="FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="253"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="372"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="426"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU63367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="508" mass="51915" checksum="7F38A5B081336ABA" modified="2019-07-31" version="1">MAITSVDYSAIAEEVYAFAAGTDPLAGPVKEALGVIDDALDTWGQDHISLSFNGGKDCTVLLHLVAASLGRRTPPAAARKPLAAVYIPVPSPFPELEAFIAAAARAYALALFRCAPPADSALPVESVPTPGAATAPPAERPAHVKGGEGMRRALEMYKARFPEVEAIVIGTRRGDPHGAKLGFRNPTDDGWPRFVRVNPIINWAYADVWAYLRRFRIPYCSLYDDGYTSLGSTYNTFPNPALRAHGGCTCGRGELDGAPSSSSSSREDARPNGSASEPQSPPANGHAASPAPSSSSPPQLSSSSSSSQQQASSKTKTKTPIPTLPDRFVMLNGSPGLMCIGEEHPSPAAAAATAAAALAPLPHRATLTDVVDPSGLECEGEPSALSRAATPQPSHPPPPPPPLGLGHDGTGLGTGAFEVLVRNPGETCTGETLDGAGGRRVNGSGSENGNGNGNGAGGCTCQAKPYRPAYELQDGSLERAGRGSPAVVVGGVGGAALDGQVGALSLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q797</accession>
    <name>A0A4Q9Q797_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_1036081</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the polysaccharide monooxygenase AA14 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q797"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q797"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054497">
        <property type="entry name" value="LPMO_AA14"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22810">
        <property type="entry name" value="LPMO_AA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043366298" evidence="13">
        <location>
            <begin position="19"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="281"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="403"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="309"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="403"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="418"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU63020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="619" mass="64475" checksum="D35C85D828881286" modified="2019-07-31" version="1">MLAGLLLTAAAALPLATAHIAFFHPSMYGFNVTQQTFPYDNRPVAPLMNMNFQQWWFHGHLDYPPNPGDIFELPAGKPATTQLSCDKGETTFFASSPGGNVQAGNNPCTGDTFPSGAMHTTGFDDLKGCALAIAYESDVTKIQPENFTVFSVNQTCVWNRFTDFQVPERMPPCPPGGCHCAWFWIHSPDSGGEQNYMNGFKCNITGSTSNVALAKPQVPRRCGADPTNGKPNAAPGNCTYGAKQPFYWFQTERNNMFEGTYSPPFYTDLYNFKDGAQNDIFEDSYPQGLPPPSPNSTFVPTPFLGNGSGSSTAGGASSSVVSSSPSGSSSSVAAASSGALGSSSNGSILSTTTGAVGSFSSGSVSSTPGSASSTAIASTLPVSSSSASSSIVQGTPDLPLSITSATISSPTSSSASSVSQPLTGNSQDGPASTAIPGSSESTSVTASETTSVVLSTSIVLSTVLVTVTATPVPTRNATSASITLSFSDSIPATASTGTSSISTQLTPTQSVFLSASDAASTIVLNFPTGNAAPTTSVLMATVQVPRAALLTARTNCKREPGRRKMFRRRPSVEPVVSNMEILDAREEQPTSAQAADTVLGMRKHKLRRLGSRSRLWNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7N0</accession>
    <name>A0A4Q9Q7N0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peroxidase</fullName>
            <ecNumber evidence="15">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BD310DRAFT_578774</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12 15">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="12">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="15"/>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7N0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00692">
        <property type="entry name" value="ligninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
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        <location>
            <begin position="1"/>
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        </location>
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            <begin position="21"/>
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            <position position="72"/>
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        <ligand>
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            <label>1</label>
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        <ligand>
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        </ligand>
        <ligandPart>
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        </ligandPart>
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        <ligand>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU63425.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="390" mass="40942" checksum="695C88CF8925416E" modified="2019-07-31" version="1">MAFKLWSMLPLVALATVAVAAPSRQTVCSDGTVVPDSVCCEFVPLAQALQKEVLMGDCGEDAHELLRLTFHDAIAISRSKGPSAGGGADGSMLIFPTVEPAFFANLGIADSVNNLIPFLSQFPKISAGDLVQFAGAVAVGNCPGAPQLEFRAGRPNATAPAIEGLIPEPQNNITEILERFDDAGGFSPFEVVSLLASHTVARADHVDPTLDAAPFDSTPFTFDTQIFLEVLLKGVGFPGTGNNTGEVSSPLPVSSGTDVGELRLQSDFGLAHDERTACFWQGFVNEQEFMAQSFKAAMAKLAVLGHNADDLVDCSAVVPKPKPATGKPASFPATKGPKDLELSCKSKKFPTLTTDHGAQETLIPHCSNGSMNCTTVQFDGPATNFDGDDS</sequence>
</entry>
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
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                <person name="Ng V."/>
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                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
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    </evidence>
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        </source>
    </evidence>
    <sequence length="335" mass="36318" checksum="5EA49076438D645E" modified="2019-07-31" version="1">MTPPANDDAESWPAVKAAAAPSNTVTGLVEGKGEGDCYLIHSLRLNYLRNIDDPYGPRLIFLCTSFHSSPSGLADATIRFPQPEGNLKYTTIILDPSRTGMMGLWVNGKCASMSRNSVMLSMRREADGADQDAPAAPTMETPITTEVISAMPVSPMKPEAPSSPIKDHKWRKGSDRRTAVRCGKTACVVPIIDFQGAAEMERRRRQRLLAWAHPPGVAPRMPMVAMDLNPEESSSSSEEEPEPEPAERRGDELADEEDEDIDRDGDSSEFSEDEFDLPSENALQLSAISTSASMSSMMASPEPPSTSAHVLHLSPIQEGKECERLSVSSDTAANS</sequence>
</entry>
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="453" mass="50267" checksum="CFC84AB50B571307" modified="2019-07-31" version="1">MSKRLKRAPPYEDDPGCKYIVISDPWPGNKSGKERGEIYWNLLAAWVRFMLNKEHEAISVYSVNTRNDVIVQLPEEADIVPILGAHPWIKVLSSGHPRDRERVSYVFAYDYRMKGEPDNHNWLAHYPTESGDPPAHIRFPVKFPYPHVSWASPKGKSCGDLALPMPPMRQPTPVRDIGRFTPYEHPSQLTSSNITAVDSISDGKAQIQRDHHQQTPRKPDPYASSEEAISLRAYRQDTLDVKPGVKREDGARVKMEAVKPEPELYGPSKSFRAAIEELQRARAAGEPMTASNEPESIGSVKPEDELHRGPSDALVAAFNSVRGGHPSESRTPSIVSSAGITKGEREETPYQPSEAFVAAIQGLRRPPSATVDELQGRFSKNISVKPEQQAGGSAKYTTAPDEPVVKPEPGDWRHGTSRRTLGTNNNDQGDIELLRVPSPLSDLHDQHALPSSE</sequence>
</entry>
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    <accession>A0A4Q9Q9U8</accession>
    <name>A0A4Q9Q9U8_9APHY</name>
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        <submittedName>
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        </submittedName>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9U8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="107" mass="11957" checksum="EDC89A54089BF05E" modified="2019-07-31" version="1">MISFIDVQFLYIEWPSDVDLPTLSYNNQCSMYALLRLYAFICMGANSQPPNHLHSWLVLDLVPDPFVHDAIDVPNALIKASTAACPSRHSFFCPTIDTLADSLGPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAT4</accession>
    <name>A0A4Q9QAT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_523632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAT4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10749" checksum="CB0934FCB669C8A7" modified="2019-07-31" version="1">MERRASIQFNSKFATTYGRLFQGVQPEEFTGKKQDVASFWSQLLDLNVDREFLFSKLHEVRKDDCLGTLRVRDLSFRLSWYKTKIDTSSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAT9</accession>
    <name>A0A4Q9QAT9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_286106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAT9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="8299" checksum="25C3253696E55926" modified="2019-07-31" version="1">MRMRTRRTYHCYPHSPSLPYSRSPSVAYVLCSPCFAFPLLVSSLSFTVPVLISSNRCRSPMRHFLAESMRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QB66</accession>
    <name>A0A4Q9QB66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S28e-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_806056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QB66"/>
    <dbReference type="STRING" id="114155.A0A4Q9QB66"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000025">
        <property type="entry name" value="40S ribosomal protein S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9844" checksum="819A4703F67711B1" modified="2019-07-31" version="1">MQDSSKAPVKLATVTKVLGRTGSRGGVTQVRVEFMDDPTRTIIRNVKGPVREKDILALLESEREARYVYLAVCRCVIVLTQISPSRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBT8</accession>
    <name>A0A4Q9QBT8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Beta-lactamase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_913269</name>
        <name evidence="2" type="ORF">BD311DRAFT_745264</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBT8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBT8"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16279">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="95"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="257"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="414" mass="45045" checksum="261AF07584FA44B1" modified="2019-07-31" version="1">MSDSTHPSHPPLSPSVIHMGSIDALHAYDDPVELILLGTGTSSTLPHVDCLTAPPGAKPCRTCLSTLTPEGWKNKRRNTSAVLRVRGRDGLPKTIVIDVGKSFMPAAVEWFPKYGLRHIDAVLITHAHADAMNGLDDLRGWTLGGAIQQAVDIYLSAETFEAVKIAFPYLVRKEFASGGGDVPEFNWHPYVTDREPFEIGDTGITVKPYAVPHGFCGAKPVKPVPSIADQIAAAVPFSTSSPCGTGMPGTPTTTGNVTPVEKEKKEDFLCLGFTVQNAVTYISDCSKIPDDVLADLLSSPIPVLVLDCLRLKAHLSHLSLAQAVEYARQLRAQRTYLLGFSHEVSHEEYEVMLRAVGGHRVPKNRMTEMVTAGLDTLDLGGEKIWIRPAFDGLQVFVSDKGEARDTAYYDYPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCI8</accession>
    <name>A0A4Q9QCI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine protein phosphatase PP2A-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_864121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCI8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCI8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="391" mass="44239" checksum="DC775F70BE854698" modified="2019-07-31" version="1">MEDVPLPSLFHRALTTASRALNLPTIEDETQELIQSALDDLRQCSSRVAKLSLFSANEHLTDIPTRDLVYILVPYALSEVLSRVRTTDRDERLDLVSNVKRYLESFVRYLELYEIITEEDKALYGRAASSVSDPAKRRELKIKQYKREKDIRTRIEALRKRKNPNATDANTNLELIASVLPDPSQNSDEASTEPDTDTEDILREAVIFLLRFSYAEAQAQLESTDQELELLRNAPPTPPQRQPSDDPRLAKKREEDSMWKLDAPVNRGGPDGKGPLLDPQGKPLRPFMILPSNADERARFQAQVFQADHRLPTMTIDEYLEVERQRGNIISGGGPASEAKPTSKEQLAIDAEQDGTVFGEQKAEEKRQKDESWAQYTDTHPRGAGNTMNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDN2</accession>
    <name>A0A4Q9QDN2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_912361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDN2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDN2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="9">
        <location>
            <begin position="276"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="8">
        <location>
            <begin position="661"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="494"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="533"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="848" mass="93550" checksum="8BB9161FEFF46A41" modified="2019-07-31" version="1">MVVKNTKKRVAQPAQRPSKKRKVAGDSHSSKTKTKGKERAFDRPTIPIPNSGGEEDVELSEDDVDMLEEYGGAVSFLRSLDEKGIARSKKETERLHQLHKPVRRRVEDDLPSINSASEDEGEEEWTSGISADEDVSGDDAASDFDDDESSIAESSSAGAQRRRRRKPIDSDQEELSFENQPRRRRPEWEPKSDEDKGIERLPIKLADGRIQKSGSKVVLEASEDSGLDSYEESAHETAASAPRPRFEDVSTGARFGRAAVADVIGQKSRKARIQGAKEQIAGICQEILGDPENSLGLLRRLHTFSLPQISTPTHPEPIPNDIVIRKLTFLSQLAVFKDVIPGYRIRALTDKEKAEKVSQMVQRTRDWEQGLVGIYQSYLRSLEVELKAKSELAETALHCICTLLVEVTHFNFRVNLMSSIVAALSRKSWDKSSDLCLDTLIKVFRADNSGEPSLEIVRLLNRMIKERKYNVHPEVLSCLLHLRLKSELGVRASETKADKDNGAGGGKTFSKGRAATRRAKGKAVDQPHLSKKAKKVLKERKEIEKEMHEAAAEVDKDERATRHTETLKLLFVLYFSILKSPKPTPLLPAALRGIARFAHLVNIDFFKDLLQVLKTLMTRDQDLIVDTNTEISGLPASSSLAASSGPGLQGVSNIATVQHQLLCVVTAFELLSGQGEALDIDLSDFVNRLYSILPSLALMPDIEVAPTSARAQASVRGLPPLQSPADTLFRALQLAFSPRSASAAPPSWRSAAFSKRLLSAALQWPPATAARAVEFVAGMVERDPKLEALLSTEDRAGNGVYRPDVDDPQVCNAFGFGSACWELRTLVSSHYAEQVRVAAARLLESRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDP0</accession>
    <name>A0A4Q9QDP0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_913538</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDP0"/>
    <dbReference type="STRING" id="114155.A0A4Q9QDP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021030551" description="LysM domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="26"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU64864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="215" mass="22140" checksum="4EB32B6BB046B2D3" modified="2019-07-31" version="1">MFSRSVVAALVAAPLVATAFAASCTRTYTVKEGDWCDTISAQHNVSTYQLAAVNPDIDDLCNNLAVGQNLCLGTEGEDCKSTHVVEANDSCEGLYGTYGINATVLYHNNPQLDAACDNLYIGEVVCVANSLVAPAPPSGTVTIAVPTSTKVATTSIAIPTSTEVATTSIAIPTSTEVATSIAVTSVAHSTVTSSAPAATETDDDDDDDLPFCDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE58</accession>
    <name>A0A4Q9QE58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_912605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE58"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU66029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8549" checksum="A6600077DA8FD956" modified="2019-07-31" version="1">MIPEGELSSGLSAATTSMTRIYQVSTLLACDPTLLPVVGSVLLLSALYYAYLPYLSWVCIPGTVAWSRRVMMMSCSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE60</accession>
    <name>A0A4Q9QE60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">anthranilate synthase</fullName>
            <ecNumber evidence="3">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_837614</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="3"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE60"/>
    <dbReference type="STRING" id="114155.A0A4Q9QE60"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="AMINOBENZOATE/ANTHRANILATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236:SF9">
        <property type="entry name" value="ANTHRANILATE SYNTHASE COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU66097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="532" mass="59169" checksum="BCC25D05BDECA478" modified="2019-07-31" version="1">MSLDTQKLPAFPPLSTVEHIILKEKQGNCVPVYVELPGDFLTPCVAYLRIAKDSKYSFLLESVVAGENLARYSFVGADPFKIIRVGPNEETTGDPLVALQKELGMYKYVKLPEVPTFTGGAIGYVGYDSIMHFESKTARVVEDPLRIPEAIFMLVDTLLIYDHLYQSLKVVSHVFCPGDAGQVNLSFIYQTAVSKARRLAKLIMSTTTPEVYQQPIVLGNEAVSNVGKAGYEGFVTKLKEHIVAGDIIQAVPSQRLARPTNLHPFNAYRHLRRINPSPYMFYLDCGHIQIVGASPETLCKVEKNKVYNHAIAGTIRRGQTLEEDEKLGAELLASEKDRAEHIMLVDLARNDVNRVCKPETVHVDHLLKLEKFSHVIHLTSQVSGVLRAGKTRFDAFRSIFPAGTVSGAPKIKAIELIYELEKQRRGVYAGAVGRFDFADDEMDTCIAIRTMVFKDGIAYLQAGGGIVYDSVEEDEYVETLNKLKGNMRALDVAERTLSQLTSFDGERADHTGPRRVLARYPKCEGCAGIMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEB4</accession>
    <name>A0A4Q9QEB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_837806</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9QEB4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1429"/>
            <end position="1726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="92"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="166"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="442"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1720"/>
            <end position="1842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="334"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="453"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="502"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="541"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="744"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="802"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="826"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="846"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="866"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="885"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="907"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="932"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="950"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="991"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1051"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1075"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1124"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1144"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1169"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1198"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1229"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1256"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1287"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1739"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1777"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1791"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1811"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1458"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU66183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1842" mass="197934" checksum="6797ABA5A0D1FA2D" modified="2019-07-31" version="1">MSSPPSPAIGQVVHEKGRVKKRDRPPALAIADPTSGSDREARYERAVGNDSRQPSVQVFAPEEHATDVETDVPRSASATSSLDPYYFGVHTPSDSPIPPVPAVPSVPSLPRTPEMRSYEPVTPGRDPAAIDRRTLVGVGELATPRWARGARNDDYEFVAQERVEEVNEDDMVEVERPEDERDSDSPWTIEAIDGEQDEKNEQLMEVKPVSRPLRSRRSVAEESGGEEILYPRYRQAQYSDAPPTPQVPSQSQSDSEVLAGSMPSAVAEAEPPPSAFATPPQRPRKRTSEEFELDNGVLVPKFSSANGTPGTAKDKDKVRRHRSLGVGIPSQATPKEKVKDRRRDTLSVSVRHSRQGSSSSSHGEAHHPRRMHNSDFSHLPPSPSSSSIQQFLKHTGNTSSSASSPLHTQPHLASNVAHSLLRGTQEGWSDLDDQTTLEALRKIDGLSGKTARARSSIGGHSRIGSSSRPGTPAKATTQWEGIESGGSIKGSKRSSMYASQSGKERGKEGAHRVTSNPALSSGEGAADIDHVATSGDDAHHSSPQPDRSAKKTGTASARSSFTPKRGSASSGTYASTPTTSSRDSASLSVGTSNTSVSAVSGRQSSGKARRNSASSDISIGHGGDPTSARDRAASLVAPADSADESHVPPVPPLPKELSSYKSPLSPSANHLPTVDYQSDLPLPDRSRRETFNDVTFPSIIDVPAIPTTPSKHSSLQVPKSTTPTNLHKTPSKKWTFSGALGRKLSSTPSNSSMKDAAQSKSPAMPTSPRAMSFGQQIRKSMSKEKPRSPASKASEDWSPINSDAMASATSLASLSSVGSGRAALSPSTAQPVGTPSTSKTPDRLVSSRSGTASSASTNVPPVPQNAPLSPSSSVRRNPSTKRLTPSSIPFFRRSSSQSMQIPPPSVPSTSISPTLSSGPASATHLRAPPTMSPTKDTSLSSPTVPSSAKKSSVLSLGLPSLLKGSSSRRSLHSDKEKSDAKSSRESAATSSDREKPKKDDKDRSESRISVLMGRKRGKTLSSAQSPPKKAEPVAMPPMQISALPLSTAQRVANLKSSSQSSLNSNSSSVKAGSSRVTAQTVSSMQKLSDTSLRRHQLPTIAGSPSVGGGTQPAVRDAKDGPPLSSLNTSTALSKETPTKIPRISSRSSAANSPTLKANGTSRRASMIVGSSSGLASSRGASPTGGSESMNEFGVLENGQVSATKTVSAPNGTTIPRKNRESLSFGLRKASTSSVASTTSGAHEQPQQTAHSHHRFSALSPSKGLKLLSPKVSLPTARSSNSSSTPSIQQTIGTPTGSRQSLSTPSPAPSSVDEEELLGDEEMMQYIKRQQAKKLQNGSSQEDLEAMLRFPEPIPPAPALSPQAVLKSDQARWLCEYECKEILDYESVYYIGARSEKKMATPDNSTNNHGYDDERGDYLVVNHDHLAYRYEIIDTLGKGSFGQVLHCRDHGTGQSVAIKIIRNKKRFHHQALVEIKILDNLRKWDAEEKHHVIKMTEHFYFRGHLCIAMELLSINLYELIKANNFHGFTTALIRRFTSQMLQSLALMRHHRIVHCDLKPENVLLRHPAKSAIKVIDFGSSCFEHEKIYTYIQSRFYRSPEVILGMNYHMAIDMWSLGCIMAELYTGFPIFPGENEQEQLACIMEVLGVPDKDFINRSSRKRLFFDTTGAPRPVVNSKGKRRRPGTKTLAQALKNPADDMFVDFISKCLIWDPERRLKPQAALRHPFITGGRRSKVPNPTPSSTAKTLLQSASSNLGSRSTKVTETPKKSLISAPTPLTARSSRTLAVPSTPSGSTSMHSTLGSSSRSYRSSQAQPMSSYHSSRTMVSPSQPPLPSEVVDDDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFF4</accession>
    <name>A0A4Q9QFF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_38433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFF4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU66026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="278" mass="30413" checksum="6495B196137482BF" modified="2019-07-31" version="1">MDTGKADMLGSGDKQLEGLEEAGGAKRLEGDTPGKGSSSCADGVPPPRAQGTVAWIASPPLTRLITFGRRIHTEALARYEETYPRILDTLRRVLKLCGLTLMIIFVVMLASWFMALSHWFTVFFGHFVLRYTFPQSLDDAFAKKNLDFTAIFAAIGALVVNLPPFLIFLLSVPLTFDRTVLEGSAAPANDFIKRITPNNWYALMFLKYAPRLSAGPVGCAIYWLLTGPDEVEDTLDPLHAAIAGAAGELVLSILGYVKNRLKRRPVGGEPITKDTLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K1Y3</accession>
    <name>A0A4V2K1Y3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="6">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_1017770</name>
        <name evidence="10" type="ORF">BD311DRAFT_650008</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 8">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K1Y3"/>
    <dbReference type="STRING" id="114155.A0A4V2K1Y3"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="9">
        <location>
            <begin position="35"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="6 7">
        <location>
            <position position="284"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU34633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU63660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="331" mass="34551" checksum="2667A1C539F6836D" modified="2019-07-31" version="1">MLRRAGQSLSSAAGRRAFSQSAARRSYDDTIRNLLIHKDTKVLCQGLTGKTGTFHVKEALEFGTRMVGGVSPKKAGQTHLGLPIFGSVKEAVRETQPDATVLYVPPPTAADAILEAIENEIGLIVAITEGIPQQDEVKIHQALRSQSKSRLVGPNCPGIINPEGCKMGIQPGIIHKPGRIGIVSRSGTLTYEAVAQTTGVGLGQSLVVGIGGDPFPGTKHIDVVKLFLEDPRTEGIVLIGEIGGGMEEEAAEYLEKYNKTRANPKPVVGFIAGRTAPPGRRMGHAGAIISGGKGAASDKVAALEKAGVLVTDSPAKIGSTMLKAMQSAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K431</accession>
    <name>A0A4V2K431_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_393816</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K431"/>
    <dbReference type="STRING" id="114155.A0A4V2K431"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024603">
        <property type="entry name" value="COG_complex_COG2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12022">
        <property type="entry name" value="COG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="59"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="COG complex component COG2 C-terminal" evidence="11">
        <location>
            <begin position="538"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="196"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF12022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU64343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="902" mass="100524" checksum="B2100ABFEAD5C006" modified="2019-07-31" version="1">MASLKSPDALRLRDPFELDRLAEELEARESSAPRKKANKPDDDELPEGAHDLPVYAPLSHDNKYLSAETFDVEQFLLSRAYTSLPDLRTELRDYHAALKEELVKLINDDYEAFISLSTDLRGEGARLESMKRPLADLKAGVLEARKTLQVVQDDIKDKLDKRAVIREQQAFLQLLLKISESITRLESLLLITSPDDAEKGDSGVGQVQPLPRTETEAEDRTRGNRAKHIARVAAEYTQLLYHVERASTQPCAFIDEHQWRVERIKSTLSSDLDHLLATTLNSLVGGHGKPSKPTEIEKSKLYADVTECLRTYDMLGLWRDAEDVLRREVVRDFVKKTIYPGALAAPRSPIVPHTPLPTRTGAASPAPPMTASLPPRTPYTPFTAFASKQNPFEFALRADAHSSSPTANLAHILDETDDPLAALYNAILRFVDRDMRRIMEIAEAVCVKSGSRAVADQGAKRGGEEPGFEIMANVVWSEIGRALMDELGSVIFAAGKPDEFRKHHETTQAFIRALEFLAPSVQSVEAMRTHIVFTSFERRWQLPVYFQLRWKEIVTKLEESLATTKLERNKALAPFDTPQAAAICNAIRACWSAEVYIPQLSSRFWRLTLQILSRYRTWLDKSLPSPEPTAKVAAAVALERIGASASSPTTRSSTPIPTEGASAESIAADDALLQQFATAITDIKALEVDVMKLWIEQLNTMLPDSTLAEDEQEATPEEALEQALSKLTSLVPTLTSQIVLILSRRGCDALLPMRSIPSQFRASAKKTPTEPSYFVSLIFKHTKAFFGIQTVDGPGAALKDVLLKPVAEDVFELVAQRYMYWLSAMKKTEEGLRKLKRGKKSYSLFGKTDDDGKADEDKIRTQMILDVDAFGREAESLGVTIQENVTYRSLAEMARSSVTEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5J2</accession>
    <name>A0A4V2K5J2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_829607</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145208">
        <property type="protein sequence ID" value="TBU53664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5J2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17872" checksum="CB971A41E5AD4185" modified="2019-07-31" version="1">MGAWRPHSAYAVLVARAWSIHPAWYDKFPIPRAASRTSSERSATAVNGTHVYVANCGDSAVSSTYVRGKHLAGDAQHSLQGSPLFNICFSRAPSRCDLQKQRTYAITCVPLDTRRTIQRAVAQCLPDAPMGTARTNSEPYVWLEFVDENISLHPWTELIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6N3</accession>
    <name>A0A4V2K6N3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145234">
        <property type="protein sequence ID" value="TBU52853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1179"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1248"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="886"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="930"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1058"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1137"/>
            <end position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1356" mass="146809" checksum="8ED00F1509DA9D8C" modified="2019-07-31" version="1">MSVLTSPAQQPDLAENWDEDFEFNRASTIPNTDAHDPRPDSSPRVVPTAPRNPSTPLSKEKEHPFKTWAEPGPSTPLKRLQQTENWDDDFQDTDSPRPSVRPVAQSQVPSNGSTSRDAGGSASPVENWDEDFDDNARSGASPRRRTPRKRGSWGSSDEEEYGFADREDDRTVTTRSRGVPFHIPTDIPPPVPPLPSPFPRSPTASVFSVPVSSTTGRESVAGYSYSSHAHLPLRPTASGGNSAAVAARLALLPPSPPIHRERRRLRKKSRPPPNFEEGIFELEDRAEFPEPPRPVTPDNSKRSRELPSTSLDDPPPDISNTSTGKTPLLSRIGSVGKKWGTGRKKRASTGPSEVMLKERSEPRVPHERVHYPESEGSRPTSFIASSSPGHGGSGAKSWFFRGGGGGQGPGSPQQAESLKHERSVERLLHLMGVDREREPGSPSSRKGKGRGGHGREGTDSTLPQDLEEVADGNDVPTSTLLFGGTPRRPTSMQVSIAASSSGSSWSTRPPVPRHVSYGDGRHMRPTTPSSRASSRQRSASASVEDVHRAKKSSTTTRETFDGHSSDAHSNPPPERPAGEEKGSRRFMGGIRRISLVGSKHKRRKSVAPQDAEKQQRPGTASSAHDTETAHDNTTPRPPARVIRSSQDIPLLPPIELQPPSPPRNKGDRKPPRDLTGSPTRASVDRTLEPSRSHPSLGSRPTQVTSSASQETTHSAVPSPLPSPSRPMPSTSPVQTASLGRTAQPPKERDTPSNANFLRRNSLGDLKIPARISQAQVSLKRDLNMVRDFAASVEQLKQLQATYTTLTSQIRTLIHDPQESQSRPVSPSFIHLPKPSTRSRAQTNPTTSHTPSRAQLNSAFLNIEAKYRLSWECAELLIDLGGGGPDQQQATSPPPSSSQSAPIVPTVRDGRKSRERAITLAGDEQKPTINPSAPGSVSPPLASPPPAQWRASTGRHDLSQRQLMLLREMLNNSDPSATMSLEPGIPEEVINRNWRWGDAMNSTVTLPSEESVPSGAQPSPTKKRRTSRLGMRGLRDMLKSLKKSYADQTQPPVLPRIPPSSSSVSASTDSSLNLPRPDSVASRRRDVHPNSPYSTAPALSHKSSPRRPSLASIFRLGQKSKAAAGPRELVDDLSNQTGLPSSSSGLASRSGTSLGDEEDWHRVESASDLEHAARALGLSSDSTATVRGKKGKSPYLFQRTVDPNGTHRLPDRSQSSLWSLGGESPQKPSAIPPSVLQSYTRSIKLSDVREVDSDVGEGAHLPRSASRSKNRQSAPSPSPRRPPSRGRIPPTGSVRSAPPQPWVDPSPNRSSGPLPDIKLAMAPENIKPLLENAREVHTRCADCITELEALLDTNIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K711</accession>
    <name>A0A4V2K711_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_886323</name>
        <name evidence="8" type="ORF">BD311DRAFT_729695</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143481">
        <property type="protein sequence ID" value="TBU24376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K711"/>
    <dbReference type="STRING" id="114155.A0A4V2K711"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24094">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000171">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000004">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000011">
        <property type="entry name" value="Heat shock protein hsp88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="728"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="756"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU24376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU54338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="779" mass="86488" checksum="72DDCA1336CE2A7B" modified="2019-07-31" version="1">MSVVGIDFGALASKIGVARHRGIDIIINEVSNRATPSIVSFGPKQRAIGEPAKTLEISNFRNTVGSLKRLLGRTITDPEILEVESKYTHVKLVDANGTVGAQVNYLGEQKVFSATQLTAMYLGKLRDTAAKELKTAVSDVVITVPGWYTDIQRRALLDAAQIAGLNVLRLINDTTAVALGYGITKSDLPEAENPRHVTFVDVGHSSMSVAVVAFSKGQLTVKSTAYDPHVGGRDIDYALLQHFATEFKEKYKIDVLSNPKAIFRLSAGCDRVKKVLSANAEAPLNVESIMNDVDVHSRLTREEYEELISGVLSRLEAPLHAALADSGLTIDQIDTVELVGGCTRIPAVRQKIQNWFGGKTLSTTLNQDEAAARGATFACAMLSPTFRVREFSMTDINPYAIKVSWERQPEDEDTELTVFPKGNNIPSTKILTFYRKSAFEVEARYADPSTLPGGINPWIAKFTAKDVQPQPNGDYQIVKVKTRLSANGILSFEQAYTEEIEEREEQPMQVDGAEGEAAQPKKKKIAKKHEVPFVWGHSGLDASIVSQFREVEAQMHAADKLVFDTEERKNALEEFIYDTRSRLDERYAPYVQSQEKEKILAALQEAEDWLYSEDGEDATKSVYVQRLDALHALADPVINRYKEAEQRSRVASELRETINNYMNQATSNDERFAHIEEKDKQAIVEKCATIQKWLEDQSVRQSERPKNTDPVFTAAEVLKKKDEIIYFATPILTKPKPKPKVEPTAGTPGEGTPKGTQTPKTEEQQQQAKPEGPSEMDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7F9</accession>
    <name>A0A4V2K7F9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_824709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU56018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7F9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="14"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="34268" checksum="FB4233C7B985FD2B" modified="2019-07-31" version="1">MFSLSALWLTRYNAVALLLYDTILTFDREVSLIWARGRAHMTMLFLVIRDVEIASLVLYIAVINFGPTSAQVSLHANDCRNPEVALVVPYFGWAVFLGWRAYALSSRNIFVGLFGFLCSVTFAAPTLVTLFGSSAVYSAHPPSCTFSYNYPEPFISAIQISRPMALVADLTVLVLTCIKTRKEWPSLNKGGPRTSLASTLFVNGVLFVSAVTVLHVVALITSLDDSLNDRTFGQITLIRDVVITIVLSRYILDLATVAAGTVEDRQADPQAILTTQWTHYDSDVTSLYSLDEEYNGRGFDKSFNDSFSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7N9</accession>
    <name>A0A4V2K7N9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_822916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7N9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="15349" checksum="B0A74A6CC28E96FB" modified="2019-07-31" version="1">MTRLFPTEIEENLLDLLSDHPQTLRNCALTCRRWLPRSRCHLLRAVSLRTREDLASLCGFLDVDPQCRQWVRSVVMAPIVEKDTQLVLETFPVPSLAALPNLRRWEIRGADMSDPSRRRALLCHKATLARLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8N7</accession>
    <name>A0A4V2K8N7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Protein N-terminal glutamine amidohydrolase</fullName>
            <ecNumber evidence="3 8">3.5.1.122</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 8">Protein NH2-terminal glutamine deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_922442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:50680"/>
            <dbReference type="Rhea" id="RHEA-COMP:12668"/>
            <dbReference type="Rhea" id="RHEA-COMP:12777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:64721"/>
            <dbReference type="ChEBI" id="CHEBI:64722"/>
            <dbReference type="EC" id="3.5.1.122"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NTAQ1 family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.122" evidence="3 8"/>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8N7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.10">
        <property type="entry name" value="Protein N-terminal glutamine amidohydrolase, alpha beta roll"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037132">
        <property type="entry name" value="N_Gln_amidohydro_ab_roll_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039733">
        <property type="entry name" value="NTAQ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023128">
        <property type="entry name" value="Prot_N_Gln_amidohydro_ab_roll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13035:SF0">
        <property type="entry name" value="PROTEIN N-TERMINAL GLUTAMINE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09764">
        <property type="entry name" value="Nt_Gln_amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="10">
        <location>
            <begin position="38"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Protein N-terminal glutamine amidohydrolase alpha beta roll" evidence="10">
        <location>
            <begin position="169"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="110"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU60678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="324" mass="34836" checksum="65226FD824335723" modified="2019-07-31" version="1">MSSPATHSSVAGVSSANSGSRSNVLSPPLPMIPPDSIYISCYCEENIYLLAQTFLAEASSRVAPWPWEIYVVFVSNHGKTVALWAQKLRASDVVVWDYHVVLVLRKAANGAHPPTRDSPGDREARGPSPPAHPRCPGAQFRPPASTTGPALQPGEADEGGDLHLAVDHADASAGASAWVYDFDTTLAVPSSWKDYVGRTFPYAFDEELKACIDGRFHSLFRVIPAAVYLDHFASDRSHMVSRRFPASTSPSSVSVPRGAPAPGCFDFHLIRAVLSTVRARGRRLGGLLFPIASGRCGSRAHVAAFVLDRTCSRGGARDQCRGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9G4</accession>
    <name>A0A4V2K9G4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1035498</name>
        <name evidence="1" type="ORF">BD311DRAFT_784304</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9G4"/>
    <dbReference type="STRING" id="114155.A0A4V2K9G4"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU34722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="592" mass="67158" checksum="7F994604FE5AF13E" modified="2019-07-31" version="1">MLNAYGSELPVELYIHICGFLNPLSSPDNIKTLVNLSAVDSYVRAIVARLSIWKVLYEDRYTHDVPEKEASRRQRFGDDWRGLYFERRALDHRALDLVDKIRTEIPGRAEHALVLAKDLSFDVWDALYEEITLPVPPYFRSDSDPCPDEPAAPHALPRSYWAKAVQGVIARYWAVTIWHGAAQNHLGIKMEDMLAAWSAFFGWSPHQIRDEFDESAEECRTLHGRETVWDQDDPNFDLRRACDTIIDYMRSQDWIGNAFDPDVDEYIVNSYPHTLLMEARDFPLTTFSKTWIFLCLCNHLGLLAYSTLVPQSDTAVCVVHTGKADHDPLLINLASDTSFYPASDLPVLKKFLDENGYLPPLSVRWFFLQSIKEAARNFTLYNEHRVAEWSDSPLDRALLASHAAQCALATTMIPSEDTFIVFPEGMADFLPLDAHVILLDALLFKTSDVVAVNNTHVEAVKQMAKQLEDLEKLVTRPSQFPGHDLGTIGKVVTAQPAQGDKGVIIGWTPSRDDSEIVLHKVAFPHGVEYWRKAELEYAGLPKEKALRLHNMLPQFGRYVEDVSFSEVDSEGNPTSFVLTAEMKTLYPDDNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Y1</accession>
    <name>A0A4V2K9Y1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_911732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9Y1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17107" checksum="EDE2DC35C04A0B06" modified="2019-07-31" version="1">MLLLRPFTIPQNLTNMVPSCCRMLSDPFAAGSTYDLTPCRPRPSKKLFPVTRRSPTSAPSQCTLRATPIPLSIVVHNDFSAPSAPAVCVFSYVPLTRLFVATFGAFTCRNFSSGGIAAAVPGIKLNGRGSKLVQMHRTGAGATLKKSPCQFLPPWKVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9Z0</accession>
    <name>A0A4V2K9Z0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BD310DRAFT_911908</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9Z0"/>
    <dbReference type="STRING" id="114155.A0A4V2K9Z0"/>
    <dbReference type="OMA" id="HGCGMIS"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="TBU65708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26136" checksum="29F6A94B0A67CDAB" modified="2019-07-31" version="1">MSKRRGTNDGPVNGGGDTPLVPSAALQQYRDTEGHFSLVRNFRLADLVTIANGICGSFSVFMSAKYLLTNKEDHLWSALAFPLAGLIFDFLDGKVARWRKETSMLGQELDSLADLISFGVAPALLAFAVGFRTYLDTVILTGFICCGLARLARFNATVALVPKDAKGKAAYFEGLPIPSSLALVGLLTYWTKQGWIAGKEGLPLGTITLWGHPGGDGDLHVFSIVFGLWAAAMVSKTLRVPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWK9</accession>
    <name>A0A4V6MWK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1006359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145328">
        <property type="protein sequence ID" value="TBU51403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWK9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="738" mass="77560" checksum="DFDD7AC9703CCC95" modified="2019-07-31" version="1">MSSTVSPTGNAASKKPMAVDPAPRMSPSVSSGSDVSMARSLSPPPPTLGIPSDLPTQISATPAGLYTQSDGPNPVPQDQLALNLNLAAEAALLPHGPLPSASPVPPVSGLGELDRYFRSFSAHFTPLSQPALDSPLPASVPSFRHPALLSARFLAAMTKLKAQPKSQRSPDDNARLGDILQAFLDDGFAHASREATDAAYASHVPRVADALEIYPFHLERIFDNHPSIINTAIRIVSWDPPAPQAPRAPSPSPHEGHEVLNFIDNLPLATIRTMPPSRSPTPMLGVSHPGLPGSIHSPHNRPPTPTPAVPTFNTNHAARAKRAATKQPATSPPTPGPSARPAPAPAPALAPTSDTTQPAPSIPASQAPTPAPVQPTAPLAPWSTMAAKCPATGWSSSPSICINEVINEKISTLPSGHAKARYFRLSAAIPEHQRPSTVTITDALNQSNFRITSASWNMTGRNLVIFPTSSLSTDDIIRLDDCVSIILSVPVTSTSYVYYSSLSISQLPSVRYRVGGASEPVDPVAYLLAAAQRSVSPAWRALTTDQVLAARWNPSPSPDSATLYVNIREDSPAFARLRALHNGTLVFDLGAGSRITVVCPVRHGILACTNCQALGHPTSACRSPPKCAMCAGPHRTFDHSARAAPDASIQYAPWTTLPSAARAAAATPLATTYALALLSAPPLCVHRPSPTVATATRPTHTVSTSSQPPLPTHQLPPQPSPRVPPPTLRPGMGWPVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MAZ9</accession>
    <name>A0A4Q9MAZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_936167</name>
        <name evidence="12" type="ORF">BD311DRAFT_766684</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143481">
        <property type="protein sequence ID" value="TBU24385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MAZ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9MAZ9"/>
    <dbReference type="OMA" id="GQPWFSD"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000010">
        <property type="entry name" value="Probable YHM1 (Mitochondrial carrier)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU24385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU54348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="299" mass="32282" checksum="65073338A60C8239" modified="2019-07-31" version="1">MAPQLNVKGSDSGTARVLGSGASGIAELLVFHPVDTVAKRLMSNKSKVSSSTLSSIIFKEYATAPLGRKLLSLFPGLGYAAGYKVTQRIYKYGGQPWFSDILGKNYKESFTNTFGERKGKMVLQATAGSLTGIGEVVLLPLDALKIKRQVNPEAFRGRGVIRIFLEEGTTLYRGWGWTIARNAPGSFALFGASAVTKEYLFGIQDYHKATWGQNFVASIAGAVASITVAAPLDTVKTRIQNANFESKVSGVTVIKDLIKNEGPTALFKGLTPKILVVGPKLVFSYTLAQSLIPWFSKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MCV0</accession>
    <name>A0A4Q9MCV0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_961521</name>
        <name evidence="13" type="ORF">BD311DRAFT_868172</name>
    </gene>
    <organism evidence="13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="ML143481">
        <property type="protein sequence ID" value="TBU24377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MCV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9MCV0"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20346">
        <property type="entry name" value="BRcat_RBR_ANKIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="175"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="121"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU24377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU54339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="562" mass="63934" checksum="56A6FD0B0D778E42" modified="2019-07-31" version="1">MSSDYEISDDENYSYEEEEEEDEMEVEDYDDGSASEIEVDGIGDDFKVPGGSERKVYEVDYMSLSQPDVEKIMATDVNYISGIFGVEPAVAAQLLRHMNWNKEKLTDKYMDNASQVSVAAGVDLPPREPTPPPPKASSSRQSSTGPTRTARRSVAETSKTSKSTKRVASPAAGVQSFVCPICFDDSQTETMALMCEHRFCSSCWKEYITSKVRTEAECTITCMAEDCNIVALDPFVKKALTDDMETWERYQELLVRQFVSCIPHLKFCPYPSCTNTVSCVSAATKSSLLTMVPIVACSIPTHVFCFGCPIDADHRPVICAVAKMWLQKCRDDSETANWIKSNTKECSKCQSTIEKNGGCNHMTCKKCKYEFCWVCMGPWSEHGTSWYSCNRYDEKASVDARDAQARSRASLERYLHYYNRWANHEQSAKLSMELYAKTEKKMEEMQITSELTWIQVQFMKKAVDVVFKCRMTLKWTYAMAYYLSLGNEKELFEDNQRDLERAVEELSELIEAPIDPETIMALRQKVTDKTVYVQKRNEIMLEDTAKGYLDGRWSWNATVDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MDZ1</accession>
    <name>A0A4Q9MDZ1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SMAD/FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_666420</name>
        <name evidence="4" type="ORF">BD311DRAFT_43377</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143489">
        <property type="protein sequence ID" value="TBU24046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MDZ1"/>
    <dbReference type="STRING" id="114155.A0A4Q9MDZ1"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053027">
        <property type="entry name" value="AGGF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23106:SF24">
        <property type="entry name" value="ANGIOGENIC FACTOR WITH G PATCH AND FHA DOMAINS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="101"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="G-patch" evidence="3">
        <location>
            <begin position="337"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="377"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU24046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="44716" checksum="AF50CB5C43586E37" modified="2019-07-31" version="1">MLEEGEIATLADSRSNSDILGPVDLPNESSLDITGATYSPSIEWPGDTDRTPVTPPFADVYAYEPVGDPRASSTSLRLVVQHSAILRKNQRLALLDGFTEIQIGRDIAPAGSDTPRIRLKEMEVSKLHATIYWDQDRTHWSVVDMGSKHGTFIQSSVVPPPGGPAAQGSDGKGFRLSAPRVASMPRALRHFDRLTIGGTTFIIHIHEDRTPCTACSPQSDEEIPLFLHRAADSSAGASKKRDFEEFAANSMESTSVRERDPKKALNMLKRTLLSSSKTPAPTPSGSHGQYVDRSARRRALHPDRSPATTPSADRSPLPSPSVSAPATPPSPAAPLSATNIGHRLLLKQGWQPGTALGEASSDNAGLVVPLDPPTTVGRAGLGASARPASASSALQEGDWKDAGKRRRWAEARESLDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MMX8</accession>
    <name>A0A4Q9MMX8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_46926</name>
        <name evidence="1" type="ORF">BD311DRAFT_308065</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143417">
        <property type="protein sequence ID" value="TBU28959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MMX8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU66200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="173" mass="19649" checksum="C9023D1833E60980" modified="2019-07-31" version="1">MSARAIMLPQRPSLFRYGPLRALEVDDFRVCQCNCDPWKSLFEKRILRATASRISFACTITMLQPACSSRLTGVHLSYFCLIAPHPRTFKLDRVAALSRQQWQDALGGAKYNAACVPVHRTSIMSVRDTTASYCTSRSCYHVSLAERTRRQRVTVKDASEPIDSRNAFDIQRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MNW1</accession>
    <name>A0A4Q9MNW1_9APHY</name>
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        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_820758</name>
        <name evidence="5" type="ORF">BD311DRAFT_777751</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143415">
        <property type="protein sequence ID" value="TBU29185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MNW1"/>
    <dbReference type="OMA" id="WSTYSTA"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="338"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="277"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU29185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU57825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="400" mass="42724" checksum="34F3A39C2CFBD0CA" modified="2019-07-31" version="1">MASVVAQDTAELRLTLPVERASTSPFPSPGSPFYPPPRLGAHEFASRPSSSRSSNGTRDSSDNKDKMPLTDGAITPTGTVASSPSLSVTLNAASPTTPTPGSAFQVKTPTTQITMPEPPSNSETPVSLNAAAAALTNSSNRDSLTSSRPAPPSPAVSRRASAALSRHSSTARSRRQSKGSFLQASHEPEPSTSSTNTVTPTPSSLPRPHSLLFKIRDFAFPPSDDRHTGRGPDAPRPNRPRKRWSTYSTMSQSSVDSSRADDEEDAGQGEWGKFPWNTLSSRFSWGQQEGGASRPSQSDLDNNFNVSSPTEEQDDPYGDEYDEGEYEYEDAQGGEEALVPGLYRALYAFEPEGTAEMALEEEQIVHVVGRGGGVGWAVVEREGGGHALVPESYLELVEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N156</accession>
    <name>A0A4Q9N156_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_837284</name>
        <name evidence="6" type="ORF">BD311DRAFT_32074</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N156"/>
    <dbReference type="OMA" id="YTLMVPQ"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF19">
        <property type="entry name" value="BINDING MONOOXYGENASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="7"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="329"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU32406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="459" mass="49382" checksum="00EAA28AA96D1964" modified="2019-07-31" version="1">MSLPSTAEVLIVGAGPTGVTLALALQREGCPGVVVVDGILQGENTSRAITLHAATMEAFELLGLAEQLDNEGTKVKKTIVWSGTNKIETTYFEPLSKYTKYNYINCVPQHVTERLLNQAAKERGISIYRPHKVVGIKPSTDDPKFTDVFFDTGHVLRARAVVGADGSRSKVRQLANVGWADPTGTVNANNKDDALSTMIIADVTATNPPPFPRDAINLILSTNNAVLWLALPGDPYPDKGVPKGETVFRVVCGIPAERGQPPHAPDAAYIQDLLDTWGPNNALPAGSPKTSISRVLWSSRFRTHSAIADSFFAQVPTLGDGTEEVKAEGGPVMLVGDAAHIHPPMGGQGMNLGIRDGVKLAPVLAEFVRVASANPSAPKAELEKPLQDWAEERRPKALTVIGLVKRLQGMLWVPHTTQYALGFIPYNAAWLRDSFLGLATKFEFFRVNGAYQVSGLGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N702</accession>
    <name>A0A4Q9N702_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_949170</name>
    </gene>
    <organism evidence="1 2">
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        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N702"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12969" checksum="910ED7DF3E35F435" modified="2019-07-31" version="1">MIDLPPARHTWVVVWGKDDSAPEFHLFNLGSLDNLDDDDMLAVPWAHLLADAPFICIWRETETCWAGVETGLDSGLLPAPITLFAHPFASTLAGSGEAIAWLEHWRLEAGMTNNSTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NCA9</accession>
    <name>A0A4Q9NCA9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_810405</name>
        <name evidence="2" type="ORF">BD311DRAFT_810940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143513">
        <property type="protein sequence ID" value="TBU23159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NCA9"/>
    <dbReference type="OMA" id="APACTIF"/>
    <dbReference type="OrthoDB" id="3191568at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="51"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU23159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21384" checksum="578EF993A4F13402" modified="2019-07-31" version="1">MNPYGQGWQGQQGGAAPSIFGALPSLPASSNSRPLQGDTVTFQFTNFKTTILNSTVYGPQQRTCYRIVTEDSAPACTIFKDNESRNIAMIQWQPNVQLETRGSGSRVRVRDWLRLSSDQSRRVMDIGGVQYAWAPMEGFICLYKVQTSAPKVLGRIARVPNMVTLELTQEAMQLGLLEPSLTATVLLSCGHNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDZ9</accession>
    <name>A0A4Q9NDZ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_780715</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDZ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043422442" evidence="2">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="69" mass="7399" checksum="D34EAD34BDE2492E" modified="2019-07-31" version="1" fragment="single">MVRLLSCLASLSRTVAGAFGSKNAEVNLSDRLEPTPSKSSQDLVLAEPRAKRSSPASLGKDDDKRPLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NEH6</accession>
    <name>A0A4Q9NEH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_976985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145119">
        <property type="protein sequence ID" value="TBU58920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NEH6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11523" checksum="998C3FBBF8C19A86" modified="2019-07-31" version="1">MIRNLFVDGKAGANAINPSPYAGRSALNIFLLLISSIGTESMSDPVMSEVLRIERQFMNVTGSVSKAVEFFPFLQKLPSRIMTSGARRLGRDMPEDQSSIYSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NF16</accession>
    <name>A0A4Q9NF16_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_953096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145286">
        <property type="protein sequence ID" value="TBU51774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NF16"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="129" mass="14535" checksum="2185D22606A6BCB6" modified="2019-07-31" version="1">MADLAGSPHSLPSASSTTQSPVLPWEVIERTIDFCAGDKVTLCTFALTCSQLHPRSIFVLFTDVDIQSEKQLIRFYDAVCARSHLQPVVRFLSFPWEKFSPFPLLSIFPGLRDDLTILHRPSQPDYPRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NH33</accession>
    <name>A0A4Q9NH33_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="7">PPIase</shortName>
            <ecNumber evidence="2 7">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_961555</name>
        <name evidence="9" type="ORF">BD311DRAFT_792032</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family. PPIase A subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 7"/>
    <dbReference type="EMBL" id="ML143526">
        <property type="protein sequence ID" value="TBU22777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145192">
        <property type="protein sequence ID" value="TBU54315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NH33"/>
    <dbReference type="STRING" id="114155.A0A4Q9NH33"/>
    <dbReference type="OMA" id="DHILYKP"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000013">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF565">
        <property type="entry name" value="MOCA-CYP, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="25"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU22777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU54315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20408" checksum="8C6ED3CABEAB2FA7" modified="2019-07-31" version="1">MSTPDAPRSPARNSRSRSASGPDVFFDIEIDGVHAGRIVFRLFDSVCPITARNFRELATGENGYGYSQSYFHRVVPQFMIQGGDIVEGNGTTGRSIYGPTFADENFRVRHDRPGLLSMANRGPHTNSSQFFITTVPAPWCDMRNVVFGEVIRGMDVVKKIESYASDHILYKPSVDVLIARCGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIQ8</accession>
    <name>A0A4Q9NIQ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_962496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145242">
        <property type="protein sequence ID" value="TBU52640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIQ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16193" checksum="2E015EAD520ABE46" modified="2019-07-31" version="1">MVAVLPQSRPSGASLSDRIPIADHSGRGVPLAALATLSDHAIRAQYPVIDIAHEKLAKLGVSRCTLRITWAGFENMGFKEDIRLLGHVIPPVKAIANAFDRFIRESVRFAGHPPAPNLWPQHYTLQDLILTGLIVYGGGIIQAEVMLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJ05</accession>
    <name>A0A4Q9NJ05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_926382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJ05"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU58715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="526" mass="58668" checksum="E3AB5C2E7B370A0E" modified="2019-07-31" version="1">MASIQTRRSLEKRGSDEKARSADEEKAFDATATVSEVVESSDGDEALRLVGRERTVEFSEEYNRKLRRKLDMIIPPLCAAVYFTQFLDKTSLNYASIMGFPIKGQQYNLVSLAFYLGFLVWEFPTVYISQKTRVAKYLGGNIIIWGIVLMSHAAASSFGAFFALRFLLGMCESCVAPILILLISMFYKKDEQATRISWFYVMNGLTQVFGGFVAYGISFDDGHLLAPYKIIYILLGGLAIIVGLCVITWLPDSPVHARMLTKEERIAALERVRDDQGGTENKTLKKEQVFEALTDIRTWLIALTTLLTSIPNGGLSNFSNIIIKGFGYTSKQTLILSTPGGVVACITTLLCGWYSDRKNERMIPIIFALIPTIVGSAMLIGLNNSGNKGALLFASYLIGTFGSALSTIYAYNASNTSGHTKKNTINALTLVMFSIGNIIGTEIFQPKDAPAYIPGKIAIMVLLTVQLFVSFLLRWINIRLNVKKRAHLEEEKAKHGWSDEDVQRERERHAFLDLTDKQNIFFVYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJI0</accession>
    <name>A0A4Q9NJI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_917003</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJI0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043411347" evidence="2">
        <location>
            <begin position="20"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="339" mass="37347" checksum="AFAEEF76C3BAAC66" modified="2019-07-31" version="1">MKLAGILFTSLLCAASAHAQYFSAGWTPGQKVADEQPPEPAYTFEPAAQAASRPAPAAGGKQLGFVDKILTSGPVSSLFGKIGLNVSEVIARGSVSPWDERIPIITDQNYEEIIVNEKLTPEEEKERVWFLIVSVTSSQNSEISKIVDKSFDDAYNETLAAGDLPHVRWGRIDYMSVTYLTTKWGIWTGPYLIVLKDRGQTLRFYKADRVRISKELIRELLTEELWRETPVWNSNFAPGGKREFVLHYYGIALMYTFDVINRVPRFVLMIASGGIASIVMRFLHKSTPQDARPKPSEAVPKKTADTDAGTAVSGGTTAVASSTATSSPKKGKQRKNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJM5</accession>
    <name>A0A4Q9NJM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_384789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJM5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="75" mass="8082" checksum="E152973D75272704" modified="2019-07-31" version="1">MFVSRSGASKCNVSTLQTQWSPSLTSSEMSFKTITEVRYGRCPVRGPPTTSSNSWITQPADDASSPAETNHSADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLF3</accession>
    <name>A0A4Q9NLF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_77516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLF3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7268" checksum="E4D3FC39AE2E394C" modified="2019-07-31" version="1">MICQSQGSQISHPAIVTGTRQPAEGVGWTCGFSRRRGFGGTLEDGYSVPTKQLFLCPPSLWLSEDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NM49</accession>
    <name>A0A4Q9NM49_9APHY</name>
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        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="3" type="ORF">BD310DRAFT_914444</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NM49"/>
    <dbReference type="STRING" id="114155.A0A4Q9NM49"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF90">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="585"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="698" mass="75509" checksum="D06F52FC46FA13B9" modified="2019-07-31" version="1">MVPTPVNHVANKYPRLTYSLFTLATHGLSKLVGYSWQDAADYTHSFAKREPKAERDNKTKFIVFACLIPILVLLSGLFAGLTLGYMSLDETQLHVLSISGTPKQRRYAQKILPIRKNGHLLLITLLLANMVVNEALPVISEPVLGGGIQSVVASTALIVIFSEIIPQSLCTRYGLAIGAQMAWFVRMLIFAIGIVSWPVAKLMEIVLGPHHGIMYRRAELKELIALHSATGELGGDLQSDTVNIIGATLDLQEKVVRESMTPLDKVFMLSIDAKLDFDTMKRIGDTGHSRVPIYEEVEVPVVSPNAPAVSRHPSISGTVTPKVPVAEDAPLPDRVQKVKKLVGVLLVKQLLLLDPKDAIPLRNIPLNPLPCVPFNEPLLTILDKFQEGRSHMAIVSRFSVEKAKSVQKEVKKGLTQRLKDRVGMGDSSSSESGSDESGDEAGTTSTSDHDATLRGDGLEGVKKKRKWGRKGRKKRKASADNVEGRTDDVELGDVQKETQPQSIVQTGLAKALSVGREQRLPDDAVLAKEQADDFIASMDPYVMPLGIITLEDIVEEMIGEEIYDEFDPESRARVAPHISPDIAKRFLSRRRGRSRDPKPGFSPASAPSGVRTTPSSPYLHPQSVASSPGTLLVSFEGGSSTGTGTGKKRGGLTSKLLGPVKRANTIDAPPSASKPSETEPGEKKDAPDIGGGGANETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NPC3</accession>
    <name>A0A4Q9NPC3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Type 1 phosphatases regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_856675</name>
        <name evidence="4" type="ORF">BD311DRAFT_766501</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the YPI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143479">
        <property type="protein sequence ID" value="TBU24447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NPC3"/>
    <dbReference type="STRING" id="114155.A0A4Q9NPC3"/>
    <dbReference type="OMA" id="HKPRQFD"/>
    <dbReference type="OrthoDB" id="307488at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU24447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18476" checksum="2571D11843E191C8" modified="2019-07-31" version="1">MSTRQARRPNASAPSDGSRTITVHDNQPHEDESSDSQAVGTLRLRGVARHRQRVVWREDVVDNEGAGKKKSKICCIYHKPRQFDESSSSESSDSDTDSDSDAPARRRCNRDHEHVHDHSEGAHGTASRSGEGSGVVHELESDSDDTNAYERMPRRKPKKAQSKDDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NSK9</accession>
    <name>A0A4Q9NSK9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_825435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145166">
        <property type="protein sequence ID" value="TBU55546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NSK9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="17023" checksum="53D0BFEDE1FA4E37" modified="2019-07-31" version="1">MGIHFAYRSAPSLLIVVYHSQLRRLGFDACHPGQQRPSSLFTLTSHLLTVVRKPMRVERPECTRDEYLTAFTAVTTYAPPPTVVQRRRVVSGLLPRDGPDLSPMRDRTPGDVKVGSVQRRQTAFPWRTLSPQFEMRASRFELALPHPMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NX45</accession>
    <name>A0A4Q9NX45_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_973833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NX45"/>
    <dbReference type="STRING" id="114155.A0A4Q9NX45"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="474" mass="51589" checksum="DAC9210FEC53ED89" modified="2019-07-31" version="1">MDPSQLVFVDDGDLNDLLFQLPDAWQHEQGEHYYSSTYSNGFTNAQAEFKFNGTNVSVYGAQLPRPSDNASAVPPSVSFAIDGVIPMVVVSDPDANTTEFAYQFFDSHTLPAGEHVLTITVEYGEDDWPFTLDYVEYTPLPALTDSTSSESMTARDGEPSHTVPMVGGVVGAAAVLGGLAFASWWYWRRKRAPARLAKKYGHYVYEDAKKKPDLATHFGEYKPPPEPTMMDTVASYPVQETHLHAYHPTPINETVLYPLTRRGSLDTFESLSEIDFAHSQMRSQFSAFSRTHTPQSSVYLLRPQPSTSSISLSRPGTPSGAYGGGLHRPIPTPPPALRRPSSPPISYRSATSHASLVSYSTTNSRAPLMLAPGSTYTSSGATPSAKRAEAEKASGSRPKKPATFHADSGVRFKKGDALPAVVAPSTSAKPPPSAFLRTDTGKRDDVEERRKNKAKYVSLAGTAISEVPPMYTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXG5</accession>
    <name>A0A4Q9NXG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aryl-alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_823551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXG5"/>
    <dbReference type="OMA" id="ICRDDER"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="345" mass="38921" checksum="AFBEE08C623838A4" modified="2019-07-31" version="1">MSVPKKMSYVRLGNSGLKVSRIILGTMQYGSSKWQEWVLEEEEAIEHIKYAYEHGIQTFDTANVYSNGQSEVVLGNAIKKLNLPREELVIMTKLYNPVPASPAVNLIALGKKPEEVGIINQHGLNRKHIFDSVKASLERLQLDYIDVLQCHRFDYNTPVEETMHALHDVVKAGYVRYIGMSSCYAYQFHQMQNYAITHNLTPFISMQNHYNLVYREEEREMFPTLKLFGVGSIPWSPLARGLLTRPADAESKRGNTDWFIGRYKNESTATIVTRVEELSKKKGVSMAQIAIAWVLAKPGVTAPIVGTTSLDNLADILGGLDVQLSEDEIKFLEEPYKPVAIAGHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1B9</accession>
    <name>A0A4Q9P1B9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_2409</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1B9"/>
    <dbReference type="STRING" id="114155.A0A4Q9P1B9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="24556" checksum="90AE70F650272032" modified="2019-07-31" version="1">MATIICRVCLEALQDKTVVSTQCGHLFCSECAGSVFSYIPTPCPICRKPQSSHSLIRLFPEWETPSETVTNTVLGQPAARNVSSPLETPHVVSRLDSDSSTSSTAFQPMSTASRPRRRGLMEDVSGTVDPEAPISTAFRPRRGVPIQLPTARRSVSHTTRSPPSPSDLRRTARGLNAVYVARGPQVTPPVAVVAVQRAPPVTLRSRSMAIAFALDLDISLSRTPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P531</accession>
    <name>A0A4Q9P531_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_918735</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P531"/>
    <dbReference type="STRING" id="114155.A0A4Q9P531"/>
    <dbReference type="OMA" id="GFYDPMR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU62596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="321" mass="34763" checksum="A948F96ACCD4EFFE" modified="2019-07-31" version="1">MSAPAPGTKPLSSAEGFVCGGTAACVAVTVSNPAEVAKTRMQLQGELAKRGAPKVYKNALDVIAKTWQNEGIRGVQRGLGPAYVYQILMNGSRLGFYEPIRRNVNKLVGAKPTDQIPLTSLFSGAASGIIGASVGNPFFLIKARMQAYSPVLPVGAQHYYKSSWDALKSIWKAEKFRGLVRGIDAAALRTAMGSSVQLPTYNWTKNQLISRGISRGDSVWTFLASSSVSGLCVLMMMQPTDTVLTRMYNQPTIPTPDGRHIGALYKNPLDCLWKTFKAEGPLGWYKGSTAHFLRIVPHTIVTLTANDIIVGIYKRVRDGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6V5</accession>
    <name>A0A4Q9P6V5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_836069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6V5"/>
    <dbReference type="STRING" id="114155.A0A4Q9P6V5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="907"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="114"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="316"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="574"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="907"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="964"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1047"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1059" mass="113720" checksum="390E57CE9F567AC2" modified="2019-07-31" version="1">MADVLSAVINDDHPLALELSSLRAAVSRYQHEAHSASLKLQRHSLETLQALDHARALERENARLKEEVAVLRANPDTTPTPAANQVPELTLALRRLSDKLTAVEETLLARTRELVDTRSELAAAQHEMEAARALTAEARAREEEGLARERVLEQKVRAVEEERRMADLVVQEYANLVRKLEGRAKGHTFSSSVSSVDIQRSANGSTATLVDSLAEGKLGLQKLLEEFNGRNELLQAEIAQLHGDNGLLYKELEVARQGAEHDRGELASALHELDKYRADDNTATKMVSRYMHFSQSATDTLQKAMTALKMRHAATLATLNAEIVQLQRALAHEREDSERVRSALDELTEDIAREAYGRRREVSLRLAFLGREENLAEHLRRWVRKAKESLERSSGSQDGSLSLNPVILREAFAKATADAEALLDTLNGQPSVEAGGGSVGSIARLALAQDTVASLTHELQEETVRRLNSERKLARIQIADHPAELNNLEQTSAVVHPVPHHIAEERRLLDVGVSASTTQMTVPHDVAADGITLPESVPIVEVVTVPSAGDVSSAVSAAGSTQSGSISTTPDEASLSVPTDSSSVSRSMGLAGKAEVKPKPEEPRSESTSMPERGEGPPREALTLHPVTEDASTVTFPSVAGSPISDSRPTDLPTPPPAVPSPGSVQDSGPVPFTPETQTTTHVSKSHAPPPLPLEATGLALSSLSPSYPSTALPSTKSEEASLLAGLTKVKHRYDDVQRGFRDCSIALKELKKALSSLPPQPVPSPSEMSSALRKAVERLSDFNEDARVELEIRIADEERIASGYEALLSIPGAMSSPGDAGADKMDESEVVKEVRAFVDGTDRAIFKAMQQFVQKLDDLEHDIASIKRTLYELPSASDLALSPLASTSSAKLGTSPNWSAWTPSFLSPPRSTSPAPTFGSVMTSPRLRHSSSFSHPRERSNVDSPTDPLAGLGLRIVVPARSPTYSPEMSTNPTGGSRASPRQRTTSGMFMLGLGMRSTSFGPSMGRQGLQQIPSRNSLASASSSRVASALSSSPTESTAVASEGPGDDGEDKSDDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAB0</accession>
    <name>A0A4Q9PAB0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Timeless-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1043472</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145301">
        <property type="protein sequence ID" value="TBU51619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAB0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAB0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="6">
        <location>
            <begin position="42"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="312"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="501"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="943"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1022"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1062"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1120"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1133"/>
            <end position="1156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1194" mass="134100" checksum="D8F61C2B0755BB8D" modified="2019-07-31" version="1">MNDPIELSDDDSGDEPYVDRRAILEPPIRSVVEALGGYEAGQYRLGDECYGCLKDLKKYWRKDDTDDDRTVARIFWATRVLPNDLIPILLETAGKGHVEDKRAIACADLITAMTWPIDLAEELKELDETYDKGADYTQLLLSHLHYKAALLRPGVLQALFAITLPCLARDAKERTERDVQIVNVVLYLVRNLAFIKDLPANTHASTDHAELAALQSRLVKGLADAHFTDLLLTIAANAADDPLFNQWNTLTLEILYLLFRGVKPADLAGDQAKQSSRTLAGLLAAEDQRRREFARKANTRHSRFGTTISVTVNPKKTASAPPDAGADTQAGPSSRSYVLHRQAALTTDSGAALDMARAKKHKAPKGKKVDELGRDDNLSLDARMVLQNFARSFVESCFNPLLSSLLKDIKAERAKVTEKDNLRLLFATKWFLEFFLCTRACQPEGARWKFGLVAEVTERGWIVWVLRRMREAQEEKPKLWTELQAGVECLTQFVLALDTMASEPPPPPKHNPSDAEAAEAEDEADVADAARLLQQQIVYNGEVLDIALESVRTYKEGTQSLAYLDAAVGLAYALLRMLERWSRRKGTGEVYVRKRARPKKRRGGQGGVPEGEGVPDVEDEPEEEKGEEEVINETMFTFDQFEQRFAHPEITRTLLAYLARYKDFTQPEQMKRVVNLMHRQAVRQKAEGLYFMVSTLHLFKQIMAEERSLPREQPYKDLVALINFILRRFFKAAEEDSFLLVEAFFPKNRGHWKQFSSKELDAIGPRPEGVPFDTRFPQDLYVKKGYSPSEQMGIAMAALTENGQMVLIEWTKQILTLCIAHRQRIIDSVDGSSSKTIDLSNMDSEDEDAMDAVLGLRGPSAEALAKINDYLIPYVSDEEADAANKNPHLKLLFRLCNFKIMDEDADELEWYIPSVILPKELQRCLNTINQYLETPIDLQGKKPAELLKKKRRRRTRRKQPESDAEDDEDGIAELRNNKRKEKRKKEKQQYKSAEFIVDSDVEMGDMDAFLEKERALRQKTAALAASTGHVATMRSHGTRKRRRKDKGDKDKRKRRKHGAEDGAGDGEEGASGEDEAAEKEQDKSDAEESELDVFGSPKRATSEPTPDTSPPADDEAASKSKPKPRPRPRARVSRSSPAAGASSPGIPRSIGSPVSGLRNASQAPSDDELPSFEALRGVAKKRTARLVLSDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAY9</accession>
    <name>A0A4Q9PAY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_941373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145280">
        <property type="protein sequence ID" value="TBU51860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAY9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAY9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8212" evidence="1">
        <location>
            <begin position="220"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="617" mass="70064" checksum="584B5477716B721C" modified="2019-07-31" version="1">MWLLSTARAELQFFSAPETVTGGYAILSHTWSDCEQSFEEIQATNQQCKTTGENPRDLASAKIRECCILAERHGYQWATELSEVINSMFLWYACAEVCFAYLEDVPSGCVLEAPDSAFRNARWHKRGWTLQELIAPALVIFVAQDWTIIGNKLQLAQLLQQVTGVWWQVLTRETHLSVVSVGQRMNWASSRSTTRVEDEAYCLMGLFNVNMPTIYGEGRQAFQRLQHEIMKQSFDTSLFAWGRSLNSDTLNPLAGHEIYKFFNTSSKNHVYLLAHSPSSFTKPFGRTIRYVPSATYPIQPYLEWQWKKDPNEPEDSPRRRYGPFGHVELPKFSVTSYGLECRFPIIESDGLTVAVLLCDTGREHVGLLLHPSNWLIQDPTRKKYHSGNGFRLASGNVAFARLISLGNDLYNLRLNGKTVTAEWRDIFIADSPPPTKRDVPMNLCYPLHSLLPAPPFRIPHWLIGRVTLLGMELRPLYVRSKPVDGKPLVVVTTFEDVNAKEGFRLILGTCGEPSDSAVRWAKATPQYSATWGLDSDVTHDCQEHHLEAWPGWTKDFGDIERTIRLSFSRCKLSPHHTVVVHIELEGRVYNAIKDRTNVRFPSREEAGLVRTGVVVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB57</accession>
    <name>A0A4Q9PB57_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 464.89</strain>
        </source>
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        </location>
    </feature>
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    </feature>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="342" mass="38618" checksum="1C1C1005C91C7F4C" modified="2019-07-31" version="1">MSSYQAGIVLNMSSLITGIQVCGAVMSLLAYDWILCLDQEMSLIWRKRNGFTWASLVYVLNRYCLLVMHALSVMTIFPMTTLSCDINVWCQHILYALSQLLFCSFSTMRVLALSGMNRPLASVTFVLSIMPAVVSLTQNAKWVPPKNQPEPYNCGVNDLTPERLNIMFPFLVRGSNIIAECLVLVVTWRYTYTTRRIVRDARIGPSLTSVMFYNGSLYFLVIASFDAVHFGFDSTHRKEFGSTTTSAGLFADALSSILISRFILNLRQVHYDAAHQSDASVSLVIHFTGQVQSGIRLLPRSLASFAQPVHVDNPDPDMKWESDRHEEPSQHERAEQRQAWSR</sequence>
</entry>
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                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
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                <person name="Pangilinan J."/>
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                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD51</accession>
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        </lineage>
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    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RSE1/DDB1/CFT1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
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    </dbReference>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
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            <end position="1403"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU52774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1435" mass="157616" checksum="D319CFF115664F90" modified="2019-07-31" version="1">MHCLRQEVLPPSGVEFVASLKFTPSTLSEAGPSSQAGRTLFNVVVARSSLLRIFEVREEPAPVSTQKEVEKERRAAVRKGTEAVEGEVEMDTSGEGFVNMGTVKSAGLNGAAHPPTVNRFYLVREHRLHGTVTGLEAVRTVHSLDDKLDRLLVSFKDAKIALLEWSLSLHDVITVSIHTYERAPQLIAIDSPLFRSELRADPLSRCAALSLPKDSLAILPFYQSQAELDILEQEASQARDVPYSPSFILDLANDVDKRIRNVIDFTFLPGFHNPTVAVLCQYQQTWTGRLKEYKDTVGLYIFTLDFVTNNYPVITAVDGLPYDCFALTPCSTAIGGVVILASNAVLFVDQSGRRVILPVNGWPPRVSDLPMPPLTAQEQTRDLQLEGARFVFVDDKKLFLILKDGTVYPIELIQDGRTVSKLTMSDALARTTIPAVVKRIGDDHIFIGSIVGPSVLLKTARVEEEIHDEDVAMAEGPATVVDTSKTVDMMDDDDDLYGPSTIADQPAANGTANGAVDNVRTRTVVHLSLCDAIPAHGPISDMTFGLSRNGDRLVPELVAATGSGHLGSFSLFQRDMPTRFKRKLHAIGGGRGMWSLPVRQQVKTGGTTFERPSNPFHADNDTVIISTDANPSPGLSRIATRSSHSDITITTRIPGVTLGAAPFFQGTAILHVMFNVTNVIRVLEPDGTERQSIKDLDGNAARPRIKSCSICDPFILIIREDDTIGLFIGEIERGKIRRKDMSPMGEKTSKYLAGYFYTDTSGLFQTFLNAEAPGEAATSTLQGAMNAGNKTHWLTLVRPQGVVEIWTLPKLTLAFSTTTLATLDPVISDSLEPPALSLPQDPPRKPQELDVDQLVIAPLGESHPRPHLIVLLRSGQLAIYEAVAASPPADPLPPTRSLTLLVNLVKVKSKAFDIQHTEEEQKSVLAEQKRISRLLLPFVTSPAPGQTYSGVFFTGDRPSWIVSTDKGGVRVFPSGHNVVHAFTTCSLWESRGDFLLYSEEGPSLVEWMPDIILDAHLPARSVPRSRPYSHVVFDASTSLIVAASSFMNRFASYDEDGNIVWEPDSPNISFPHCETSTLELISPDGWITMDGYEFAANEFVSCVVSVPLETVSTESGMKDFIAVGTTINRGEDLAVKGAVYIFEIVEVVPDASLNIKRWWRLKLLCRDDAKGPVSFLCGMNGYLVSSMGQKIFVRAFDLDERLVGVAFLDVGVYVTSLRAVKNLLVIGDAVKSVWFVAFQEDPYKLVILGKDPHHCCVTRADLFFADGHLSIVTCDEEGVVRLYAYDPHDPESKGGQHLLRRTEFHGQTEYRSSLLVARRPKAGDPEIPQARLICGSVDGSLTTLTYVDENAFKRLHLLQGQLIRTVQHVAALNPKAFRMVRNEYVSRPLSKGVLDGNLLATFEDLPIGRQNEVTRQIGTDRATVLKDWVSLVGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDE6</accession>
    <name>A0A4Q9PDE6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribonuclease H-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_200203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145233">
        <property type="protein sequence ID" value="TBU52874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDE6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDE6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="93"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="454" mass="50267" checksum="B67E2977EAFE5446" modified="2019-07-31" version="1">MGQLLSQPAAEPPQPKAAEAPRKPSLNAKTMATTIPMRTTISNAENDPVVIEDDLSDSNIVAVKPRPKSQALSKAKSSHSLYSYKQYRPAPAVVYTQHEEEANDLVQTLKGPLGFDLEWVVNFRRGKKPSERRTALVQLSDARMILLIQVSSMKKFPQKVKEVIENKDIIKLGANIRNDGQKLFRDFGLHPAGLVELGALAGLADPSFKQTYNRSIVALAKVVEHYTHKTLDKGKVRTSNWDAKLSQAQITYAANDAHCALSVYNVLMAVAAGQQREVDWRSCAADLAVDYREKCVVNAQAAPTIPSQAAMTSGADGGADGPQGSASMSAPTFTQSQSQPERRVWNPFARQPSSCSTSSSQTWVQREPPRPQHLRAYNLWYHRDMPLADICAALRSKDNPLAESTVISYVVRALQADPSLPFSMERLKAFVQLEAGSWRRHRDWIFEKDGYKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDT2</accession>
    <name>A0A4Q9PDT2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_938814</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145227">
        <property type="protein sequence ID" value="TBU53030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDT2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="6864" checksum="9DBE2F239C076128" modified="2019-07-31" version="1">MCEELASYPSPSSTVPTSTATSSSKRPSPASPTLLKPQRPPPTPLIPSHPRLHPQAPPVLSLNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEE4</accession>
    <name>A0A4Q9PEE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_982599</name>
        <name evidence="2" type="ORF">BD311DRAFT_811522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143543">
        <property type="protein sequence ID" value="TBU22410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145321">
        <property type="protein sequence ID" value="TBU51442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEE4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU22410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="28846" checksum="3FA319D799CA9C5B" modified="2019-07-31" version="1">MPGTPPIEKQQQLLAQLAAVRQQIREDEERVERDRAERKKAEWERRVRKEVELLERERARLQKELAERQWAEKEQARKPASERVESTWSFPEAGPSKRRRDNDNDGNSDDNNGNNDNNNEIIDTTPKKKRAQTETVWAPAKKSCAECKEKRIACLFSVGRSRARACQVCARSKTKCTGGQWVDKISAVVISDDKPPVGLNTTPDPSADRATETRSRSRHELEPRIRLLWIWIRCGSGSANGQHTDPLQMIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEH8</accession>
    <name>A0A4Q9PEH8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_830281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145217">
        <property type="protein sequence ID" value="TBU53320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEH8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="357" mass="38596" checksum="14603DCF9CE9CEF1" modified="2019-07-31" version="1">MVLAGESSHTVGRTLTYVSVVLVIYDWLLSLPRGVRLFHAGTSRGISTYIFISNTYIHLVNQCLLLCTYASLSEKVCKSSLLNTNYVWSYLSMIPPALFTGLRAFALSQKWSVAILTFVLSFMPVATGMIEFGYHPTGSVDPILGCLCVLGRILRNRGLILLTVTVITRIGTILADALLIALTMLSFNGSTVRQAASTISTKSLMGIMLRDDIANHCSVSPSTLCRCISHSASYFPISHSSISCMITSHFMLDLQEAHQRKVVGLASNDPLYISNIGTGSLRSPSILGSLSAHIEAPRWDIQGPNFDEEAKANIAEAIIPDSTLRLIVDSVAQGSPLHNQSTLVNVTDGAMDGEAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFZ1</accession>
    <name>A0A4Q9PFZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_274465</name>
        <name evidence="1" type="ORF">BD311DRAFT_328741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143422">
        <property type="protein sequence ID" value="TBU28413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145275">
        <property type="protein sequence ID" value="TBU51952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFZ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU28413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17493" checksum="7C9D4BB1189E8694" modified="2019-07-31" version="1">MAPTAPYITERPQDRTLPTCKRVASSFLHRTVPISQLVRQSSIIDSGLYLSSHIASCTISDFQVGQDSVRCLERLSLVLNSLESTSEVRIESACAIHITGDFNRGTSRETLGVCALGVIEVLDRFTITPSSIYSQHHRIAPRASPSVSNNRRSLEHVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFZ7</accession>
    <name>A0A4Q9PFZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_963111</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145347">
        <property type="protein sequence ID" value="TBU51276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFZ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="293" mass="32285" checksum="E9148AA48CB0683F" modified="2019-07-31" version="1">MLTVAVVRFDAYHPGQQRRLSLFTLVARLFTGVWLPTRVERVTAPRRRCLAATTSFDNGRKPGRTRDEYLSASSGVTTYAPLPTGVASSADCCLKTPATVRPLLQARRDTRRQDTRRWDTRGRLCRKCAAVSGLEATTFEWRVRTRTRITGHVCQTSNAGECPTLSPHSKMRASRVELGLPVGPPSARLTALSVDGGPTHGVANTRVHIKTSTYARIRPRMDGIGRNSKWLRGRKLPSIQDAAPRYGRPLLRSMDVPGAGLFVALGTSTAYAGSQRAPKYVVRARTLSLFNGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG71</accession>
    <name>A0A4Q9PG71_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_942250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145329">
        <property type="protein sequence ID" value="TBU51396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG71"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13908" checksum="D10FD379CA9DE731" modified="2019-07-31" version="1">MGEAVCCSSRWDCIRLYCTFSHGPGPVCLAHCSGVPTLVRFPLSPPLPALCMHARQCRSRSPCILDSWVALPCRIDHRIACASAYYAHMPCWIVVEGDERYSLPTRMLYHIVRSHHSQDSSCVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG73</accession>
    <name>A0A4Q9PG73_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_952890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145265">
        <property type="protein sequence ID" value="TBU52122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG73"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="226" mass="24407" checksum="E75CDE9B63EA8856" modified="2019-07-31" version="1">MAQESHLLPRAPPLGFNPSVHQSKSNPYVQLHLLTSLGGFADAFLILSMSVNMLATSLIAYKAWEYRRMVKKYFSSDGSTTSTWKALALLVESGTIYCALLMFLVVYQLKRPFVITSSASDFDKIGWYFADGCLLPIAAIYPTIIILLVAMRRSPIEHGVSQANEESGTGPGPATASTLIFGRSAVESMGTRHSMISAVELGDQGGPEQVNEGLSSSEKIGVVVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH28</accession>
    <name>A0A4Q9PH28_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939321</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145235">
        <property type="protein sequence ID" value="TBU52817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="17431" checksum="CC6FFA0170E79A00" modified="2019-07-31" version="1" fragment="single">MDPGNGRKRAYTSRICKALRCITLAAASSSTLLTNSPRSPTSERAPHPPPSSFPPPPSPPPCLRIRPRRHEQRHGGQVRLQPAQLGPSADAGRAGVHSPTNQTSGAWACSVCPVWCHSVHNLHPAFLLRVLSTDQSSILLIDDTYFRLSTQSTACQPACPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH32</accession>
    <name>A0A4Q9PH32_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_909871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145235">
        <property type="protein sequence ID" value="TBU52827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH32"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="557" mass="62649" checksum="CBD0EB89409CEAAA" modified="2019-07-31" version="1">MRISYGPVSQFHSLSVKQLYRLDTRDYVLRGLEPIATSTVVTTMSSPTYPRHETDVDVLIIGAGPTGLGAAKRLQQIDGPSWMIVDCNSKPGGLAATDTTPEGFLFDVGGHVIFSHYQYFDDCLCEALPRDTDWCNHQRVSYVRYKGLWIPYPFQHNISMLPKEDQVRCLQGMIDASFDAAATTSVPNNFDEWILKTQGEGVANLFMRPYNFKVWAVPTTDMQCSWLGERVPAPDLKTIVTNVILHKTTEDWGPNATFRFPSLGGTGGIWSAVADTLKKENVRLGKQGKVVSIDDIRKRVLLQDGTTVKYRQLVSTMPIDTLTDVIGDAELNSLAGRLVHSSTYVIGIGLRGHRPERIGDKCWLYFPEDDCPFYRATIFSNYSPHNQPPPEVTLPTLQLADGSKPPFSARLPGPYWSVMVEVSESPNKPVHYDTLLQDSIQGLINTELLRSDDEIVSIYHRRFEHGYPTPSLTRDDVLQELLPRLQERGIYSRGRFGSWKYEVSNQDHSFMLGVEAVDHIVYGSAELTLNRPDYVNGSRNVREACGRGAPYCRYTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHF6</accession>
    <name>A0A4Q9PHF6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_938687</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145223">
        <property type="protein sequence ID" value="TBU53157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHF6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="11589" checksum="7E14D56DAA205ED5" modified="2019-07-31" version="1">MYSWKQHEPIVVCDGSICVVAIPFGALRGSFAALAAHRGSSRSPSPRFTRNRRRRGPAETYGSSTAAHARASLLPQELKEGSLCSDSIGPVLSSPSIVQLEAAEPLVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIV8</accession>
    <name>A0A4Q9PIV8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">TPR-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_886893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CYC8/SSN6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU53996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIV8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIV8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017053">
        <property type="term" value="C:transcription repressor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000403">
        <property type="entry name" value="General transcriptional repressor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000078">
        <property type="entry name" value="Transcriptional corepressor Cyc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051630">
        <property type="entry name" value="Corepressor-Demethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056413">
        <property type="entry name" value="TPR_CcmH_CycH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017:SF1">
        <property type="entry name" value="LD02225P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14017">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23914">
        <property type="entry name" value="TPR_CcmH_CycH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4 9" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Cytochrome c-type biogenesis protein H TPR" evidence="11">
        <location>
            <begin position="87"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="89"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="231"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="268"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="9">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="480"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="677"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="760"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="904"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="965"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="987"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1026"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1072"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1145"/>
            <end position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU53996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1169" mass="127794" checksum="F4F5A8FC055F332A" modified="2019-07-31" version="1">MSIRHTPRQAERDIRLHDPHHSHSLPPPSHPHPHPPHLNGNGLATPAAHAGPSRGAPLASQVLSPSAQPAAANGEDKTNPLHILNQANEQTWLMIGRVAEQMGNLEHALSAYENALRHNSHSLPGLTQVAGIARIKENYPKAVEYFQAALQVQGDNGEVWSALGHCYLMQDDLQKAYAAYQQALYFLPNPKEDPKLWYGIGILYDRYGSLDHAEEAFSSVLKMDKDFDKANEILFRLGIIYKQQGKYAESLECFDRILRNPPSPLAHADIWFQIGHVFEQQRDHVRARDAYERVVHENPNHAKVLQQLGWLYHQDGSTFQNQEAAIQYLTKSLEAEPGDAQSWYLLGRAYMAGQKYNKAYEAYQQAVYRDGRNPTFWCSIGVLYFQINQYRDALDAYSRAIRINPYISEVWFDLGSLYESCNNQISDAIDAYARAAELDPTNTAITQRLALLKNAQATGQALPAAPGPQDVHPTAYANPMMPPAGLGGPPLMMQGSTRPLFPSDARSGPTDLPLPVPPQLQSRNSPGPFRGGPPPPVVLDESRHAPSHAPLAPMDVDRPPMREHSNSFPPPPGRDVGPRGPAGGLLHHPAPQSQGPPEALRHPQHPHESPFHPMRVPSTSASPPPYARPRSVMMNYPERPPLGPAQSSSGPRRSSPPPAYPREEPGWNRRVPVEVPEWDREPRGRPVDYTRAPPSHIHSRPHSPPVPQRRNSSRSARDRSPPEVSPRIAHPGYPGSQYWEPKTGVAGPARRASPPPTRPPVHEMAHESAGRRYDPAREYEREVMLEPRGPDPRYAGSPDAIRMQIGNQQQLGAGARTSESPHLAAQQAAQLGDPKQGRRRQTRDKDAESNSSGTAGEPAKKERKRRAPQQKRVKEEGQRLDGQYENGPVQSAFKLEYRPTKGVGSPDPSSNGSASASRSVQPSPTNSTHFTPSRHLDEDYDEGVADALIGLKNYQPSDPRGFGAPSGPASARLPSAASPPQQHLARRPSVSSRTSPSTNKRPLSPGPEDHPDVKRSRVGSMSQRVSPPTNGRPTPTPGSGTRLSPIPFRQQPTSHSPDMRQPPQDSARSSYPPSPQLPITLPPHPRPIGAGLAGHLPSMTTTRSPPSNVTSPAEDERMHSRSASPPRGKIMLHSAQGSAGSPVVNSKGTSSPTSGNGNGTNARPSGPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJH9</accession>
    <name>A0A4Q9PJH9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_828395</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145193">
        <property type="protein sequence ID" value="TBU54260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJH9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJH9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="100" mass="10803" checksum="19CD109F518F310F" modified="2019-07-31" version="1" fragment="single">MPVLPITNILRFSVPDAIRISTHDDSTFTNPLPTSSSGFTLNALGVAGFFGGDSAVNGMATANLVPYRRWFGWYNTPGSYEIAKKFGPLADWAMSDGLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLM5</accession>
    <name>A0A4Q9PLM5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_961058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLM5"/>
    <dbReference type="OMA" id="RYPAMMM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU55110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="342" mass="37514" checksum="323241DE44A7E1D4" modified="2019-07-31" version="1">MPGTILKRNIGDATFPAIGYGAMGIAVAYGPPLPLEEALKVLDGVYASGITHWDTADAYSDNEFIIGQWFKRTGKRNDVFLATKFGLGRYWEGDETRTINGDPEYVPKALQRSLEQLGVENVDMWYLHRADANVPIELTVKAMAEQVKAGKVKYLGLSEVSADTLRRAHAVHPIAAVQVEYSPFTTDIEDEKIGLLKAARELGVKVVAYGALGRGLLTGKYTDPEQFPPTDFRRMIPRFSKENFPSILKIAEGLKKVGEKYGASSGQVALAWLLAQGEDIIPIVGTTKLDNLKENLGAYDVKLSPEDIAEVRRLADGASVPGDRYPAFLFHTLFADTPALQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLU9</accession>
    <name>A0A4Q9PLU9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ras GEF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_711412</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PLU9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="557"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1324"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="135"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="196"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="380"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="903"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1024"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1154"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1271"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1495"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="397"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="915"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="955"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1154"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1184"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1209"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1274"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1293"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1508"/>
            <end position="1518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU55162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1652" mass="179792" checksum="29501CA2E47320FB" modified="2019-07-31" version="1">MSSTQSDELLDASAEAIDPPAPPPPTTPASPPAALPRPTVSSPNSQLRFVSPDAGEAPTFEPLPPEIANADISIAPDGSFVETSSGAAARELKRRYDHIFGVGKDIRSPYAITALVNQHGKQMYRVGLRELSAPAAAAQDAEERQSTSLASHSAPPGSSTSSPQPGYARRRSRMSVHSFLPVSVFKSGITPVAFPNTVFDNTRPPPTAPRRLRKTRSIPSGLVANGPAGEGGASVSPVPQATGRPHAHSVSSADAFAVAVAQQTSPETQAPRAPSGPAGDFFAEVMSWTNAPASPMASSSSSLPFQHQPPPSRPPSTHGRTGEISNPFGPGVSFDSPSWRSPAHLASTPALREMQSFESGLTARADYLPKMSRMSRLSLTSAASDEDPRNLTPPPGGSSTPPVTSSASSISSVPPIPETPNVAPVNLAATTLHSRYSTALFDVLQTYRGLPTLDKIVSTPNEPTIRLSLRAEDSVAPRDDPRFVIWAEVDTDRDAYDEVAASSATDLSSAHSHAASSRRSRMGGKEKTHQMLSNMYSMQPPTDFGGAPNAPAGAKETKKMLVAATIERWIAQLTSELNYDELLIFFLTYRTYVPAVDLGHLLICRFHWALGEATTSRDEMVRKIVRVRTFTAIRYWLLTFFDVDFVPNRELRLLFAEWLNSLRRDPILQKHRDALKIVRQLRKVILDCKDAHMRKLYRAARKSVDRRKSSDPNAHSHPATAVPRLSSPFDPSYGPRPSVDSQARSFNDPEDFDIDFDFDEPGQDYAFWLPSGNGTSANALDLVMMRQPLHMAVLQYGKQNPAAGAASHPNAAISPFPHSTISRVFVNTIGRLGRWRRVLNSRATVQPSMTAGVDVSAFDVEANETGDLLLVKGGVEQYLKMVESQINVSLVERPPTSSVAISTMGVSVSSPPPQSASLPQSPRSPSSVVRVRPPETLSPPPERILEDEEPESEESVVPLSDPPSYEQAASLQYRNSIMTYDSEIHSVYGDQYQAASIPDEEAVRRAPQELDIVSIDDMDLSDLSSDEHEIPPPPGLGLKKPTRKLPTRRDFEFVRQSMSSVSSMGIRTRESVLSQESSIVSSSSEVDAENGEAAVVQGPLQAWQINAILDSLSDDDESGDAEAALRRLEGQINEVKVKEKQNKVDQWIQSIHQRQADGRFGREDEGSGSDEDYGEVERRRFSGDSAQDITIGMSATSPQAGSRRTSFTSVSQVPSASDSSAALPSTSATSPEQLTLDTLQLPADRADEGEAATPLSEARPFVEDAVPIEILNSRVPSRPSTSHGSPSKDSRTPQPPPNMPPPPSVPASIQLQFRRHRSFVLNYRAEVLMQHLSMIDRELFISISFEELITSHAIGAADDANVLDWSHFLRERARLKAEGRGGSKTSALMAVRGRFNLLANFVLSEIVLTHPSERALVINKFIRLAWKAYLMKNFNALVAIITGLKSEWVTKARRQAFSKIGTWEARVLRDLTDWTSSAGDFKHIRQTVDSLVEAKSSAQEGPVKSADGQAQTTRSRAASDTRPPQDPACIPFFGVYLAQVHHFCSLPDLIDPTAPHEPVGIDPETNTFETPAHPEVFSTLAPLPPSIQLEPLINVHKQRLISGVVKSLVAGQHLASKVQYALDKKVFQKCLKLRGLDADTLERALALYAEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP48</accession>
    <name>A0A4Q9PP48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_979121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP48"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="243" mass="26249" checksum="1CC13841AA7D7BFA" modified="2019-07-31" version="1">MSRSTSQAVPSNLLGNTTSSSSPAPALPTSDAPQGSSSSSRRLGPEAAFDSDMEDNDVDSESEGYNVKKGKQRVFNNANRAVLRRTRERLISQVTGTTPRQPAPPPPAPTLPALGPSAGLDPPRVPGGAHQPHMSVWPEATPVQAADAWSDYVPLNHHQYWELVRLARAQGGGAYNHVRDLLRQYDANGALGGFNYLHQLKMSWSDPHWAETRSQAHVAQAPLFAAHSLPFDAHLPSSDHFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPH6</accession>
    <name>A0A4Q9PPH6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_824651</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPH6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPH6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="418" mass="47751" checksum="2A6008ED32802F68" modified="2019-07-31" version="1">MIGSRARFPKPTEAYELLKAFGTNIIATEGDEWKHQRKIVAPAFSERNNRLVWDETVHILEDVFQNEWGDKEVVDVKHIMDLTVPITLLVIGVAGFGRRISWNEDKIAPPGHSMTFKDALYEVSHRLWMKVVFPDWMLGLGTPTMRKFLRANRELERYLAEMVEARRSAEVKEERYDLFSSLLDANEEELDSGAKLSNSALIGNVFLFLVAGYETTAHTLAYAFILLALHQEEQEAFYQNIKSVLPADRKPTYEDFNSLSYSLAVMNETLRWFPPVVFIPKVNVEDTTFTLTSPTTGEKRTVPVPAGTYCSICTPALHHNPRYWDAPEAFRPARFLGSYNRDAFLPFSAGARGCIGRGFAETEGVAVLTMIVVRYRVEVKEEARFAGETFEQRRARLLKSQHSLTVYPERAPLVFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQF5</accession>
    <name>A0A4Q9PQF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_931306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQF5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQF5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10527">
        <property type="entry name" value="SET_LSMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="383" mass="41820" checksum="3905258FF040A929" modified="2019-07-31" version="1">MAAAEWIRGSEVERELHNDEGGSLQGEIDDFYVSDVYPLLSSMDMQPTHAGFLRAYSLVCSRAFQIDAYHGLSMVPLADAFNHSHENHVQLASEYDVCPACGSLSECPHDREDGSSIQADQPIAVTPSIDPTDTVDMVTVRSIPPGVEVFNTYGETLGNAALLARYGFMLNGSEADTVTFGWHGSSLELRPGDSYWKSVYDLVVEPAGGILASSLMVYFPDMEPDISPVLSIDSDGRVSIALFVWAIVKSMSVQYGAESTELIVSVLRCLLRVEALRDMEERDEDIEIPSEAGPPPGPTAALFLAQTAKELDNLCRTRVANMGRVEYRGTNMEVLGEVFDDLPADRPKTRLALEYLLGERAVLEVCAAGWEEVKNIADTLSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRA1</accession>
    <name>A0A4Q9PRA1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_881783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRA1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRA1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF39">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="350"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="475" mass="53919" checksum="2E5C7FB77E5E1F7B" modified="2019-07-31" version="1">MFDVTPPHKVPITVYGGPSTGKKTLISLLNHRVYRCPWSGRRLSFAAELSTRQVDATVAFILVDARQPSSDIEEDTVAAARRVAQSICILHTKTDLVPGDHSNRHLGYLGSHPYLSYKWDVDCLSASLATGEGVDDILAYIGRIASESASVHQRDIRVSLQKLWSFVLDCIASCFALPPPTQLPDVSAELAAVTTDSDVMSLMHNVLDNTWGKELKSRLRAEDPSAHVTVNRITPSLIVKHPSPSERESMKFVRQNTTIPIPRDLCPDLSMLVMDFIDGEMLYECWDRLGRFMQFRVACTLRLYVKQLRSLTYSTPGALGDRLVSGILFEEYVYGPFRNARRFRRFCEYVAFEGWKAIARMAIGSGTVPPEPPRPSFPWTPVFTHGDLNMSNLVLDRRGTLWVMDWANAGFYPPILESIIMRQMHEIWHTDDIPPLWRRYRGFIAGKTSKEDEEFWDNFTGTIHRFPSQSSQRYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRU9</accession>
    <name>A0A4Q9PRU9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_930041</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the VPS29 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRU9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRU9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000089">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020935">
        <property type="entry name" value="PdiEstase_YfcE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01269">
        <property type="entry name" value="UPF0025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU57119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="213" mass="23640" checksum="DA27AF6946FFC1B6" modified="2019-07-31" version="1">MVLVLVIGDLHIPHRIHDLPAKFKKLLVPGKIQQILCTGNVCDRETYEYLRTVSPDVHVVRGDYDESSFPLSVTVAHSPIRIGVVHGHQCIPTGDLDSLNAIARQLDVDVLVSGHTHTFQAVEYDNRFFVNPGSATGAWIGSYNGDITPSFALMDIQGPVVVTYVYQLIEGEVRVEKIEYRKEPEPVREAPRPTAMPQSIPSTPGPQHVQSVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRY0</accession>
    <name>A0A4Q9PRY0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase C-terminal-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_822204</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRY0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PRY0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="100"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="26665" checksum="12E21EE6D90C3085" modified="2019-07-31" version="1">MRLQQSSSMSAQICPFAQRTEIALHEAKADFVRYEIDLQNKPEWYAPKVNPASKVPAIAYGGPEAPPDDPSPQSVKLAESLILVEFIGDLFPQASILPADPVKRAQARFFVDVVSNKLVPGYHQYLQGKSSADDLYKVVESLESLLPSEGFAVGEYSLADIAITPFLARARVALSNDLGAYPQGEGPKVLEALTNKQGKFPRFAKYFEDLLARESFKATFDEAYLTERYKARFGNLRNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSE2</accession>
    <name>A0A4Q9PSE2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929457</name>
        <name evidence="2" type="ORF">BD311DRAFT_764434</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143460">
        <property type="protein sequence ID" value="TBU25517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSE2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU25517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="131" mass="14012" checksum="5D04DB16A6BAF1E5" modified="2019-07-31" version="1">MLDRKLCPRGEGMKAERSLGATEKTRGKGSALGTSARFTRGDLDRTRQCRGLPSDTRYGGRTRAGNGGSSTASGYLCTTCLCATANRPNRRAGDGTMRGRVKENAGTSEERKSGLMIHFATDVARVQCGTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTV0</accession>
    <name>A0A4Q9PTV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTV0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="81" mass="9260" checksum="3E401486CEB6FFE1" modified="2019-07-31" version="1">MLTLSANWAVMIAIVVLLTLVHKRLRLRRLREIREYYEEQVTYVIRTGHADCSRSNPCQFAQGSCLATFCGCRSAREGKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVI8</accession>
    <name>A0A4Q9PVI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1015384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145125">
        <property type="protein sequence ID" value="TBU58384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVI8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="456" mass="51780" checksum="883417691DDE3965" modified="2019-07-31" version="1">MPDLEDDDAYVTFSSLENHAPEGWRMYTHPRGSIYFRNDRYKVIVDEDIRISTHLSKVESLCANRTQQSLADYMEIYMAYGVDASMCLFVNHKQCVASYDLAKVSAGTTIRRLPVDSLLRFRRLYWNFVTHHPSHRPCHEEGYREAIDALSAYYHDHLIDGSRSVGPFSKVECEQLLEALQRAKDVTGEIMPSASSMLGWILKDVYSFRTGQRYGQITWTEMRTYRKALYAAPEISTPESVITKTFLQIIIHGPFFGIPQTYLAHIKKASEFRGHVAGLRQSWEAYTRQLVQEYSDFILIVSISATVGLLTVNDIDSITRAAALLSAFASLGSITIGVFFVWRHQRNNTEVPSSFAYLHNARNSAFGLSGHAILLSLPPVLLVWSIIAFAAAALAYSLRGISINSAPAWVVLAIFIVVFVAVTVGLYTFWTIWRWQSQDTWWRGLMCWSRSPANRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXB4</accession>
    <name>A0A4Q9PXB4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_877237</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXB4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXB4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="208" mass="23165" checksum="817EE7A1EA3F2C3B" modified="2019-07-31" version="1">MSIMEYNGGSVIAMVGKDCVAIASDLRLGNQALGISSNFQKIFPMTNRIFLGLPGLATDVTTLKETFRYRVNMFTIKEEREIEPETFAHLVSSTLYERRFGPWFIEPVMAGLQKTHDGGYKPYIAATDLIGCLNFAKDFVVAGTASTKLFGVAEGLWEPDLEPEDLFETISQTLLNAVDRDAYSGWGAEVYVLTKDKVIKRTLKGRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXR1</accession>
    <name>A0A4Q9PXR1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SET domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_948082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXR1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXR1"/>
    <dbReference type="OMA" id="CSHRERF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="117"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="7">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU59316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="652" mass="70264" checksum="50C8B66D9F8985F9" modified="2019-07-31" version="1">MSFGKLKSARKGKEIHSFVKPESVSGFSDTMKADTSPGPLPSQSPMQINAAAPKNSHDTMVTDEQAVVQHSPLSQASEEQAPPRTQEHQSPTNPTPVKTRESTNSVNLHGCHTDLPSFLEIRESSRHGRGLYAKTALSAGEIILSIIPHVFVLSTPNLEYYCSACAAPAATAGLKRCPKCKTVRYCNSDCQNRDWAWHRRECNALQKWAASAPSSDVAIPGEPVRCLGRIMWGSQKEGLDSVWAQEIRMMHSNRNSLQPSAFGSHTHLAHSVVRYLGVSSPQELEPYGLKSAGDLVDLISRFTTNTFTLTTPALTPIGICVSPTVALANHSCDPNAALVFPRADGGSRVKEPLLSLVALRNVAPGKEIRISYVDTTLPNRLRQNELKEVYSFSCQCKLCCRTTAADPREALWCPKSCGGICPYPTEESGDRATHCVKCNAQVGDVGAVLDALRVGQEALDKASSLQSKDRVKARQLTTNITPILTSAGVTPSSHPLLALTRLHKELLIDSLSSSSPTQETLDEAVRTAARYTAGLQALLPKGHPVRAVALGELGKLLAVDEPAPTSASDYAGAEKFPPSGPPRLKLAYESFVKAHEELLIGFGKKSGGGLLGAEIREAIMRLEKELGIWTTGIRNVLEDTLVSAQRVGPPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY25</accession>
    <name>A0A4Q9PY25_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_817125</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59509.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY47</accession>
    <name>A0A4Q9PY47_9APHY</name>
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        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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    <accession>A0A4Q9PYD0</accession>
    <name>A0A4Q9PYD0_9APHY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="10141" checksum="A3CAFA0A0D0F856D" modified="2019-07-31" version="1">MADNFNIAHAISCSSFSLFVDLIAYLCRVYLRQSGERVAMIDVAGKARCIPVSIYLCVAQPISRDYRTVRKHCRRRFHSYVEILLTIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYJ8</accession>
    <name>A0A4Q9PYJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924527</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PYJ8"/>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
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        <location>
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        </location>
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        </location>
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        </location>
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        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="361" mass="36888" checksum="B78626BDC20512C5" modified="2019-07-31" version="1">MASKAAASGDTHTANGTAGTSASSTPSPSDHRIAVDARKRKLDAPNGPPSSTMPSGSSRPRSRSPAGPTVATAARGRLLSLPPRPSSATVAASGIGTPSAPRADRQRHVPPHLKGQARGTSPHASRQASGSLVLPTGGSAVSTADYTTRHIADKVQAEKVVGNTQDDSRVTLGTGSTQSAGGLSVRGAAGRGQAADTPMLKVEEAKVVPSLLRRLAGEASSGTGAVPPTPDHEQLQKGKERGQGRRNKRERDEGRDRHKPSPPSVVPAKRRADASSPAVVPPSKAPFAPVSTSGRAGRGPSSTDPDKDPVVGFSIRGAASGASPATREGNRGPGSLLERLQAGDDVGSEWSGRRRKRIKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PYT3</accession>
    <name>A0A4Q9PYT3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arginase/deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_924366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Fungi</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arginase family. Agmatinase subfamily.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU59851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="114155.A0A4Q9PYT3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033389">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via agmatine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005925">
        <property type="entry name" value="Agmatinase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01230">
        <property type="entry name" value="agmatinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358">
        <property type="entry name" value="ARGINASE/AGMATINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11358:SF28">
        <property type="entry name" value="HYPOTHETICAL ARGINASE FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="chain" id="PRO_5020240039" evidence="5">
        <location>
            <begin position="28"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="405" mass="43299" checksum="D3D3089D9005C7B0" modified="2019-07-31" version="1">MAFFESLSRLVAAVLFVSPFSHILVQGAGNVEYPVGIANTAAYGTINFTEIFAAYGHDKSNVAFGTSAYNGLTTFMRALPVRCFGADAATKYDVAVLGAPFDTATSYRPGARFGPNGIRQGSRRMSLDSINVAAKIRISDELDVVDCGDVPMVTTDNKVALRQLELANAALLSGSSLRTWEGKSIAKDGKFHPRVLTLGGDHTITLPLLRGVASIYGPVSVIHFDSHLDTSRPRKLVGGPWLPDEVVPVGHGSYFYYAHKEGLLAPDNANIHVGIRAPIDSWEKYADDRAFGFVISHAEVVEEVGWQGIVKAIRDAVGDNPVYITLDIDVIDPGMAPATGTPEIGGFTTREIKKILQGLSGLKVVGADIVEVAPGYDSQDEITQIAAANIGREILGLMAKTPLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ16</accession>
    <name>A0A4Q9PZ16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_924282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZ16"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZ16"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02257">
        <property type="entry name" value="Peptidase_C19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="187"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="427"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="483"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="676" mass="75384" checksum="71014744F3880E88" modified="2019-07-31" version="1">MIESRQMPPTAKELESLEILRGIMGDEMNADVALSLLRRNDGNMDKTASALLEGDTGDTVDPSIYADLPNLEPLDAPMQGPRTPPPSRPEKAVIDLTKDDDDKELARALQASLEDQGSTAFGPSNRAPDPNWAMVSSNVEANVPSGMSQDDQAMSRAIEASLSYNVTEDTFEELSLEDKVRKGDTPVALRPTASGLVYAALLIHALGFVPQFRRTLAEWAPLPAEGTTEIWPPDSGPGRQAWTLLELMVNMDLALLGELNADDGLRDLAAEPWISPAERLGDVTSRFYEKIVYAIQNVLQYNNVYNPERQPRRLMMLSHGYHDAPADDPNTDNLCFVKVAVGPGPELNDLVSALAAEFAPPVTGKLKGVAKRHVIFEPSDIVAFQLVRDSAPPTYDAALGRRTERATFKYSSSIYLDQFMRESYELASAKRAEQRGLLEEVRELEERKRNLLRYNDKDVLADLQSCLYYYENIAESNGDVKRNQDIQANKKKLANIIEKIQEEAKAIDATIESKRTEAQSKLDCPELQKYRYDLRAVLVHDGLYGRSHLYSYVKHKGQWWKTLDYHVTKVSEETALTDPAGLHLAAGPYFLVYSRAVSEEEENARTEWPENLKNSVKHNNRLFLAEIPEDVAALIVDPNSPPTSPPYNLLTPSELTIESDIVEPPESRGELMDTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZA4</accession>
    <name>A0A4Q9PZA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_947603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZA4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020383939" description="Beta-glucuronidase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="3">
        <location>
            <begin position="480"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="658" mass="70160" checksum="4619C1A8857F7F86" modified="2019-07-31" version="1">MVEPWVSLLILLALHGSAHAAVTVYGIGGVQNPTGSQSGSLPISTLGSTEWTSALGAWNDIQLQAPPLPVPLPPTAFTVALANQAEHVTNLSIPQRGDFYGFSIETSVVEQVSNSFIQVPFLNLLATVADRAGSVRVRVGGNSQETATLVGSLPNNSMIEKAASAVVSNSRTYPKCELLSTAQAQIPALIFTDELLYLLNNVSHLVSAKWYLGIPMNDTSHLRLQIAEQADAILGDNVLGYQVGNEPDLYATHGSRPPTYGVQDYFNEFGTVVDGLKSDQKITEASTKLVAPSFQGKWKAEDLWATGYLNAYAPAIKTISFEHYADNNCAAEFPDGGFGAIKNPQDVFPEYLTHANGQKMVAPYLNSAALAQQFNKEFMMFETNSASCGGFPGVSDSFGSALWAVDYGLQLAYSNFTGAMLHIGGSNVTYNVSPPTNISLFQKFTVGPTMYSTLFMAEALGKTNTSRVVDLTTNEFTPVYGIYEHDTLARVALVNFMTEQNGVGSYQATISIGGGLTGEPNATPASVKVKFTFGPRFQVDGRLIGQEIIKEIPCDQTANTCTIPVPAPGAALVFLSSDAQNNADSVVTQTYSTTSVTNRLATATLFPSAIAQSNGHRGADFPLSGTSQGGETTAKNLPPASLQQTVFIIWARAMMVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0N4</accession>
    <name>A0A4Q9Q0N4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_957518</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0N4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0N4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="318"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="270"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU60693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="526" mass="55642" checksum="3DA7EE5566B08175" modified="2019-07-31" version="1">MASGGLHSLATIIKRLEATTSRLEDLASLATSYLPPSAQGAVAAPSVTSHSSNAEPTPVPPPPPPPQAAAAAPAETPRSVIAFDEQIVEGKLKPFVELTKSFASPSVVEQVGLVEQEFKDLRELLLVAGSCKQPDQSEFEKLLGPLQKDIEAITRAKEANRKDREWFNHLSTIAEGAPCVGWVTISPKPGPFVSEIKDSTQFYGNRVIKEFKEKDPKHAEWVKGYLSLLEELKKYIMEHHTTGLKWNSNGIPLAQYKATSSGAPAAPAGGAPPPPPPPPPPAAPPPPAAGAPAPAAAGGITAVFEQLNRGEEITKGLRKVDKSQMTHKNPALRAGGVVPATTPSASSAPAKRPVKPSKPQALAGKKPAKFALEGNKWLIEYQENVSPLTVDNVELSQTVNLYGCKNSTIVIKGKANAVTLVNCSKTSVLVESVISSVSVTNSPSFALQITGKAPTIQLDSTDSGQIYLSKDCLDVEITTAKCSSINISLPVEGEEEGVFNEQPVPEMFRTTIVDGKLVTTAVEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1D5</accession>
    <name>A0A4Q9Q1D5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_329214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1D5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="164" mass="18994" checksum="8CD55B483ED2D1AE" modified="2019-07-31" version="1">MHLMTWYPDQISPTACKLSPVAPSSFARYARLCFESLPVRRRYKNGRKDQFARAWERDHSSELNAVSEGPPRKRLHKFLRFSTNECCNCYVLLLWSLLRVLSWLCSNCVVTPRVVYHATMLYNTDRDSVCCSWSPLSRPAMILRSPYTTSLNCASERSSHLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2F2</accession>
    <name>A0A4Q9Q2F2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_813530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2F2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8788" checksum="7146E39EC52457F9" modified="2019-07-31" version="1">MSQEAMRACLIMPSSATCWRQAMRANARRKPTICLQKQEIKTAECPPKEKAAHTTNTDSERNDNSEWERHNIDIRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5B4</accession>
    <name>A0A4Q9Q5B4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_945962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5B4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF29">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="833" mass="92205" checksum="5B62FF4B933FA36E" modified="2019-07-31" version="1">MANTSPTSHRSPTSGSATGRSRREKPRLELAADQPLTTQGKPRMRVYVACVQCRGRKIRCDGAKPVCHNCSRRTENPHLCTYDTAPKRRGPDRVPGARQRSAGGIGEKPPRRRRRHQTQDGPDQLFVTSQSASVSPVEAKPTSFSPTGQAFLANTSAPHSDNLTIIQEVGPVHYGRHRQGLPDSSRASMPTGVGTHYPQPHNLTQAAAFEAMSLGSPLSDAPVGSVGYPLVAPLHHGLLLRHVTGSDDEFSYGDSGGGDEDCKGVGIARDPGLQFTRETWWDALLLLYASEGGTAPQYGASVTMPPGVRETTTARITADLRFIFRASPHWLHFINLPRFFGSLLDPRARHYIQPGLILGALALAMFFRSHDGEGGLRGRERALTLRDQAQSALEASLNSRWVDHGLVQAAWLLAFFEICAHPLHSTARVRSSMGLLDSLLRSLNLLALDSGNPKASVFSTVVPIISTRSLRQLRPLSPEDSSFPRTSQSPVDSRSLATHGWSPIERQSAAATSSCSCTAFTLGHSWAMVHEIAPLWDMTPTWQSEWTESDIRMEECRRLVWSSVMLSSGHSSYTAARSESDVQQLFMMDPRNYALLFPGESLTCVDGSPDIPPPSKDSVWALYMRAMLLWNSCIRLRTDTSLPDTDKAQFALTAWTEIEAIEEALGRHTCGIERSFLFQGRELLFNSRMVIAYEFQRCLPQPTQHANLLFYRRKAEEWLTRQAILAKRLANADYGSVTGLPTADLTKRPFLLFWFMSLIERALTLWSYDQSLGFALDVAKTLSQPVEYLMTLWPCAEQRRRWEDLQEKLNRSLFAATVPVPPSAVSIPPPGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q626</accession>
    <name>A0A4Q9Q626_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1036691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q626"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q626"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU62054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="28298" checksum="FD262AE5B6A0AABD" modified="2019-07-31" version="1">MSSNYDDTPLPDGWIREFDPKSKHPFWVDTQAKPPRSIWVHPFEDEQFLAEHPDIRDRLAAERPSEQPPPYTPRRHSFSGSSASGSRLAPPARSDAIGTSHSHPGTPVAGQSQHSRGFFGKLKDKAIGTKEEREVRRRAEDEENKRYLAELQKRRQQRAQMSPSLGSYSRYPQYGGSSSYGQSYGGGYSQPMYAAPAGSPFGLGGRRTGFGGGGFGGGGIGLPLFAGAAGGLLLGDMLGGGFGGGGFDGGFGGGGFDNNFGGGGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q673</accession>
    <name>A0A4Q9Q673_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_917494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q673"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q673"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU62953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="186" mass="21007" checksum="F0A166BC88DB86D3" modified="2019-07-31" version="1">MTSPGNFRLKPSCLPDAPLPGLPPAPPYPCPFLTDEEITTYLLPLYSRGWTVRPSKTSGGNKPAPELVKAFSFESRSNLDGFMLKVSELTQSENHHPTIDDSSDEATRTIRVHTHSGLRPASHPGERRKDRVQPGITLRDIRYAYLFEDLFERCEGARYRELERSDIRAQPTSPEAIEARRHHVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q783</accession>
    <name>A0A4Q9Q783_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_768623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q783"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q783"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="440" mass="49986" checksum="80D9E9F65A99BBA5" modified="2019-07-31" version="1" fragment="single">MDYSPFANASQFRLLDHFYGRSDTHSLDALDDLISVIQSPGFSAADLDGWQTSSVEIPLPRTYAKYKSEAEAPKFTVPGVVHRRLLPLVKLAIQDPESHLKHVYHWLAHKRFWVPPLSHTSVNPEPSSSTSSLPDTPSPIRVYTDCYNSNAMLEAEADIHQRPRVPGDAPDMEYAILPLLLWSDATQLSSFGSASLWPIYLYFGNLSKYFRGRPTEFMAHHLAYIPGLPDAMKDFYMATYGKSPSADELKFCKRELFQQIWLLLLDADFMHAFEHGIVLTCGDGIVRRLFMRFFTYSADYPEKVLIAALRPLARCLCPRCLTPKDKVSEAGTKLDDHRRMVLRQDTMALRANILRARKNVFRGYSLAGKRVMSWLDAESLTPIQSAFSIRFADHGVNFYDLLAPDLMHEFELGVWKGTFIHLMRLLAEKGGGAVEEFNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7G4</accession>
    <name>A0A4Q9Q7G4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose-binding domain-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_810981</name>
        <name evidence="2" type="ORF">BD311DRAFT_755737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7G4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7G4"/>
    <dbReference type="OMA" id="FFGRITV"/>
    <dbReference type="OrthoDB" id="10052260at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000421">
        <property type="entry name" value="FA58C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00754">
        <property type="entry name" value="F5_F8_type_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50022">
        <property type="entry name" value="FA58C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F5/8 type C" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="148" mass="16536" checksum="6D2D161C240CB4FA" modified="2019-07-31" version="1">MSERMDPLIDASTKIKVSSTLDKSVGKKFLTDGSPETCWTSQQGTPQYIQLTFPKPVSPKRVEITFQGGFVGTRTLIEILENGEQKWRTLTHIYPEDVNRKQAFDLTSTEAGIADANVDSLKLVFEESSDFFGRITVYDLQLLGSVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7W8</accession>
    <name>A0A4Q9Q7W8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_584905</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7W8"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7W8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF8">
        <property type="entry name" value="ACID PHOSPHATASE PHOA (AFU_ORTHOLOGUE AFUA_1G03570)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020778381" evidence="2">
        <location>
            <begin position="20"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="472" mass="50601" checksum="2874CE05F77E131E" modified="2019-07-31" version="1">MRAALVLVSTLACAGSAFAASAFTFEPPAASPESSSANYTGQTNNTLSNGPLVPGKAFDRFIQIWIENTDYETAASSPVFQNLSTQGLLLDSFYAVTHPSEPNYIAAVGGDFFGAGDDNFYHIPQNISSVVDLLEEKNVSWASYQENMPYDGFTSFNFTSEDYLNGNGTYTYYVRKHNGLIIFDSVANVSSRALRIRNFNDFANDVKADVIPQWSFVTPNLVNDGHDTTIDFVGDWLNYWLVPLLADTKFNNNRTLILLTFDETETYTINNRIYTLVLGGGLPENLRNTTDSTFYTHYTALSTVEANWGLKALGRGDTNTTLNNVIDFVAKKTNWTNNGLAGNDTRIPLLNITGTIPGPLNAEFYIPFVAPNTSGVSAGGQGVFVSPLLDTALTLAKAPQPVNLTASGQANPWGTDPGFNYANGTEVIQPPAASASSTAPAGGKNAAVKLGAGVREGLLVVVGAVVGALMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q875</accession>
    <name>A0A4Q9Q875_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_523364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="27220" checksum="2C90867011FE2E3A" modified="2019-07-31" version="1">MQRLTLNSSGVHLPVELYNHIFGSFSPQSPWTIQTLLSLLAVNSYVRAIVSSHPIWRSLYNERYTHHVPANEQRRLSQWSGSDRWYHMYFERVALDRRALRLLDEIRTQIPGRISRASVLARELSFDVWDALGDEMTAPLPTYFRSTYDENGDLPPAPHAMPRRFWAKTAQGIIARYWAVTMWRRLYAGDPTVSTTEALAGWSAFYGWSPQEVRRIFCYCRGYRPPNSIAIHLD</sequence>
</entry>
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    <name>A0A4Q9Q895_9APHY</name>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <end position="110"/>
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            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="214" mass="22024" checksum="619D95057F9AD324" modified="2019-07-31" version="1">MLDCLDIQALDTSSLASPGTITQIAPCQDLDGLDFSGYYPTPLDSDALDAFLTSLLNSNVSPSLPASIPTSLFSPSDVQRPSSRLSLSSSLTSSRGSSPTSSPLDTPPSSPSIAAISLDTSFSGRPSVLSFPEDDLLASCGVNACDHSSSLLSLGIDLDFGWQTLLDLDPSTWAASPSSHISKPSPKPKESVGGLDVASSSAIAFIQDDGRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q959</accession>
    <name>A0A4Q9Q959_9APHY</name>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU64123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="481" mass="53628" checksum="B18600FBEB54785A" modified="2019-07-31" version="1">MPVHACPCTTFLTANATSIANYHWHPEPPRPFRCPTLPIVPRLTLPSNIMTLAEPLPTQPATMADLWSLQTELSSLMAAVRRIQDSARQATQAADDKVRRLQSKVEELEADNLARVLEIRQLDLEKTELQRELEAKRPDLAAAIASRDAAVKRLDHSLKVIEDLVRDREQATVRTGANTNNADRDNPRSKANGQPTTASAPVPRHPKRGTPAESDEESTVRPQRSASSMAVRTPRTPPTSKPESAKVKRSLSSAAASQEPAADNSGARALDASKGQPDPGARKKQVPWYLEFSKRPATSEVWHGPIPYDNLAVHLVLDQSTEDDLQHMELMTGYDTRMHAVDTNLVFIYRPVILEGLSGTYLIGWGDGGMVRNVKTWAKTAGDCHLFFYPAVELEQNAGWYYVGLHSLSFTSVDPVWHKLSKDDKRRLFVELQDRNDGMDVGQFKRDVKEGRLQQCCVQIESRGTKTESYEFLRQNGLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9C2</accession>
    <name>A0A4Q9Q9C2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
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        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="434" mass="46587" checksum="6EDD11629A6F8014" modified="2019-07-31" version="1">MPPPHTIKAHGKYDLHIGPHIFSNTALYEAHYLPAMDPDSGQEAQLPHDPQVSTSSSYVTPALSAKVQLAAQTNPTLANLLNAVINHTATDEEVKRLGVLIRQLEDISDLGSASNPPPSSTPSVPVRAGSPKPFDLLLEFHEKPSDRWILPRGDVFCERVGVADGAWVRYADVIITMCITPSSPPSEPPPTNQQPSDSPIPEVVSFRFSRVPHSLWELLITWAGGLQKMEESKARLVDLVRAAAPPSYLQHHVPEGELLTELQNATAPSYTMKSIKPIGADSTRAKRKSVSRKPTLVIPDTPPTRAEKPTPAKRRQSLKAKTSAPPTPIACHACGQTDVPLMMGGRYCRTCIDAGKTVADVPQAQAAPRGVITPSSSQPDFVPVSTSHQAVPFTVQHTGSLAQAKTAPSQVATTSSNPTNSYQIPSSKPSTQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9R5</accession>
    <name>A0A4Q9Q9R5_9APHY</name>
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        <submittedName>
            <fullName evidence="10">Fungal-specific transcription factor domain-containing protein</fullName>
        </submittedName>
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    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF78">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zn_clus"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
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    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
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        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="208"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="887"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="892"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU63791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="950" mass="106849" checksum="8117212CF58E996C" modified="2019-07-31" version="1">MSSVQDHHASLSLSEEDEFPNEPGSSKQPGIKRGTRACDRCRRIKSKCEPGSDDRCKNCEVANTPCTFQGPSFKRGPPKGYIHSIEQRWHQVECILATIMESPRAQDIIADLRNDPFASAILDRVQAGPYGLRNRMQHGQPTSESFYSSLIEVPEHTPLRDDRRSRRQSRVSREIVSQDPTGSATPTREWQEHLARRLAQSNQWAYTSTPVSPISRSSSSTGGGVADYSRTRRRLDNPYARPIQQQNWDGLYTLPDATPPSADVGDIEETAEAFGHLSVDENKEFRYHGPASGLPLLAQSSTRKDSDNQQIQRIWKFTGSENPQQDPLHEEDDVEVEMPSPETQKYLLELYFAYVHPFFPVIHKQDFLQNYHASVLDAPAAIQSGNPLIRTPMQRPCKMLLLAMFAIAARYSSRSEYQPTRGDNLSFAGQQYAQDAHKLLDRKYQSSRPSTCQALLLLAIREFGMGAMDKGWLYSGMALRMAIDLGMNRNADNWTTDGKQYVFTEVEKQIRKHIWWSCCISDKLSAVWLGRPITFRANDYSTPLLDVNENDENELWQPYPPGVLPDFIPREAKLMTTFREACRLSIIITDIMDKIYPVQVSSNTPRRVLFEELESRLNKWLIELPDDLRYPSNDRHATVLPHVLMLHIEYYTAVLLLHRAFLPPYDANAHETNLQIDPLALKAFDVCAGAAVHMSSMTETYSNRFGLERAPPFLCIFLQSAGIMHVVALGRRPSDPQASIGLTRCIEACKQIERTWPTATRLRTLLEGAKVHLDKSKYPSNVHRHKRSIEDALGGYSNSDAQDAYVLPPLEGYRGTANMGNDWDTQQARMAAHSLGVAGPSTQASTSFYPGYQWWPSQLTMAMTAPVEGPPVSAPMSYGTLPSYTPHPPTSIPASSHAQLPQSMQGPFTFNQGQMSQDFVQGVSYPSFNFDRYAPSQPGVGRPPDPALPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9X7</accession>
    <name>A0A4Q9Q9X7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="9">Glutaminase</fullName>
                <ecNumber evidence="9">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_955415</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="9"/>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9X7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q9X7"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="12">
        <location>
            <begin position="5"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="10">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU63851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="560" mass="60517" checksum="3713156940CD4AF2" modified="2019-07-31" version="1">MGLYLLDYGAGNVQSLANTLKKLGHDFQWIASPADFDKATSLIFPGVGAFGSAIDGLVLRGLYEPLRDYIASGKPYFGICIGMQVLFRSSLESPSSKGLGIIPSAIGVFANADKSVPHMGWNSVEFLDPDEKAHEGLDPRASYYFVHSFRAAYDWERPDVGQWAHTTTQYGQEVFLATVRKGNVFACQFHPEKSGPAGLKVLDAWLKQSEAERATSPPTPRVARHPKPKDGFTKRIIACMDVRSNDDGDLVVTKGDQYDVRERTANSANVAGAVRNLGKPVSLSARYYAEGADEICLMNITSFRHSPLLDQPMLAVVRAAAETVFVPLTIGGGIKDTVDPDGTPHSALEVAGEYFRAGADKVSIATEAVFAVERMRERPSTDGIGEGDGTSAIETIAHAYGRQAVVVSVDPRRVYVEPDYDGPYKGELVYGKPDGPETERGKAWWYQCTVRGGRENRPLSVVQLVKGVEKLGAGEIVLNSIDRDGTGAGYDLDLIALVRRNVRIPVVASSGAGNAKHFVEVFQKTGVEAALAAGVFHRNEVGIDEVKATLTAAKINVRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-05-29" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA59</accession>
    <name>A0A4Q9QA59_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_914715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA59"/>
    <dbReference type="STRING" id="114155.A0A4Q9QA59"/>
    <dbReference type="OMA" id="HIRAKSM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="110"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="267" mass="28316" checksum="D0F736F16DEDD1C6" modified="2019-07-31" version="1">MWQENNAAYGASSSQYYPQQPVAPQPGVPLQFYAPSPVGSTFYSGSRSSLDGHVGAQGSIQQGGGAYSGNIQPTGGWWTAFGTGGFEGEPPLLEELGINFSHIRAKSLAVLNPLRQVDEHIMDDADLAGPLLFVFCFGTFLLFSGKPQFGYIYGVGVLGSLSIYTLLNLMSEKGIDAYRVVSVLGYCLLPMVAVGALSVVVTLDGTVGYLLSTLSILWCTYAASGIFTAVLRMSDQRFLLAYPIGLLYGCFALLSVFNVGVGNGSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAD2</accession>
    <name>A0A4Q9QAD2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoserine O-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_914957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAD2"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAD2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005757">
        <property type="entry name" value="PRK07581.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="60"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="335" mass="36810" checksum="5E044FD20EAE3291" modified="2019-07-31" version="1">MAGNAIQYYHHGRFAVAGGVLPDAVTAYQTYGEPSNPCIVFPTCYGAKLGLGSQLYLVGEDKALDTRKYFVVTFALFSNGESSSPSNTPVPYNGPYFPAVSYEDNIRAQYAVLQDLGVKKVRCVVGFSMGGQQAYHWATIYPDFVERFVAICSSARTSPHNKCFLEGPKAALKASRDFHDGHYTSPPEVGVRAFARAYSAWAYGQAWFRDHLYQMGGLYPTLEAFLKEGWEGRFVANWDANDMLTLLDTWQRGDISIVRNGGDFTNALRSITAKALIMPCKTDLYFCPEDSVNEVSMLRDAELAVIDSVWGHAAGGGANAANVAFITKKITEFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAF0</accession>
    <name>A0A4Q9QAF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_279953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAF0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="484" mass="50377" checksum="3B6B1AFD40CC28DD" modified="2019-07-31" version="1">MATSTSASSSSKRTIIIAVVASIAGVLVIVAVVATIIYFGRRRARANAREGSRDGVIAPDAAPIDQENPNASGWVEGTWAGDDESELPSAGGTRRTLSSGRRKRGPSNGSASASSIPNTPSTRSLNKPLPTVSDIQIPRLPFSRADPVSPSSSFGNLGSAPPNSATFFVSPPPPVPPLPSANAPPTRPPRPPESDTFLDLGQSFTDTNLSTLSTHAAHPFATAQSYTPSAAGYTRQRSATNTSTTIPPPSASTGALAAATRGHVYASAAAPAPGPSRKRSGSDLSRDREREHAYARANAPSRQRSGSDTPNPSPYTRVAGGPAALRQRSGSDLEVNYGYRSAAPPAPARKRSGSDLESNYASASASAMSPTTTAYASTLPSTATSPTSMTALVPKRGPSPQAKEKSPAGSLSLAQAETSTPQGQAENRPREQAEEQQAQSLARARSGRRVGLVMSDRDRQRFGFLDVPQDAGDSRPPSYREADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAG6</accession>
    <name>A0A4Q9QAG6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fungal-type protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_944389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAG6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="113"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal-type protein kinase" evidence="1">
        <location>
            <begin position="369"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU64579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="531" mass="60377" checksum="30918CD2D3975A8F" modified="2019-07-31" version="1">MAAERRFIGEQMNREIVAVSFESFIEYYAPFQPSSEVVDKCLERLRTDGLVVSTTAGVDRFAGFQEPPSRQYTSRKVAYGHLSPWTTEWSVVPWFKNPTSRPMNNDPRWTPIYSVTIEDEAMCFWYWSRSHSAKSEAVDITKDVRATIRGLVCFLFASMPELGYDKTVQRRFDPALGGYCFIFLVRDSYFKVLRSIAEHLGPCTIAGPSTRVFEVIKVPSFDNITATTESAASPMVLKDVLQDGQDPPQLIGLNDAEKELLRNALRDDNYREYFLAINCDMQGVQSKSLAPKAWCNDVFSFWDSSSDRIRQLYAVPPPADSARSSSPRANSRSFVAKRQYRVVFKKVCQALHRVGDSGTVFKALKDCLLDYAKEFDAKGTRSSDPKIGTPAFMATEILSQELILFSNSSVSSKDKEAARGEPIIHNFQHDLESFWLLLWILTTRLPTCTPGFDLKIYTDQLFLVRGLFYIWPDRLNPYRNMTIGLDVRRYLPDDMKVFADCIQSLNKALYDASINRLLDFGNTASYAPLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QC35</accession>
    <name>A0A4Q9QC35_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_913042</name>
        <name evidence="7" type="ORF">BD311DRAFT_793190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU34843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QC35"/>
    <dbReference type="OrthoDB" id="5563033at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009598">
        <property type="entry name" value="BCALP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259">
        <property type="entry name" value="BLADDER CANCER 10 KD PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13259:SF1">
        <property type="entry name" value="BLADDER CANCER-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06726">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01396">
        <property type="entry name" value="BC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU34843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="275" mass="30965" checksum="2E9C639AF1253378" modified="2019-07-31" version="1">MMWCTRWYLPLVLLPMPIAPPYFLLLFLFSTTMHARPCFYCMVLLTAMFMSTCYWPPVPIETPLVQPWSENVTTFADALHLMMPNLPEERMPSTIPVADRCWCDFSNGFFAPFNATKWDELSVVRLKDSLEKDIAAEKKESDRQRCERGEGEDATVSAACADVPGELQSNVSVLATAQNGSESEGRPHFWNIFRPFKRTPTLPPTNASSDEADSASLPAPAASPNATSAVPTDSREPQESAQQSVPPKPWLRREYDLRQYGFAMVLDFGWPDTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCM4</accession>
    <name>A0A4Q9QCM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_913952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCM4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13834" checksum="378AC7FBC692AC4E" modified="2019-07-31" version="1">MHEYLHMTRYGCFFFVDAQYLGGRSSLQYSYSQLAPLGWYHSMIIVIPAVDPWVLRVNNLIIPKPSRCSVRGYQHTPSVFSMDTRSAITCGVPVSSACLLPMQLVIAGGGLVVVQNERRTLPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCT4</accession>
    <name>A0A4Q9QCT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="8 11">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_864419</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="8 11"/>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCT4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCT4"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01488">
        <property type="entry name" value="Uba3_RUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.520:FF:000001">
        <property type="entry name" value="NEDD8-activating enzyme E1 catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.20:FF:000003">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014929">
        <property type="entry name" value="E2-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030468">
        <property type="entry name" value="Uba3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08825">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01181">
        <property type="entry name" value="E2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="E2 binding" evidence="12">
        <location>
            <begin position="349"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU65593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="432" mass="47862" checksum="6B541C0A7EDFA3DB" modified="2019-07-31" version="1">MAAAAVVNGTASSSEWEGRYYHVDQILDRSGPRTDPSFLAGDEVKEFLREKCKILVIGAGGLGCEILANLALSGFKDIHVIDMDTIDISNLNRQFLFRQKDVGKSKAIVAAEFIMNRVPGVKVTPYFGKIQDKDEDYYMQFNLIICGLDSVEARRWINATLVNMVDSDNPESLKPLIDGGTEGFKGQARVILPTVTSCYECSLDMLNKPTAFPICTIANTPRLPEHCIEWASVLEWPKVHGDKKLDTDNPEHISWLYQVAAARAKEFKIEGVTYSLTQGVVKNIIPAIASTNAIIAASCCNEAFKIATSSAAYLNNYFMLIGTDGVYSYTFEHEKRDDCPVCGGQSLAITVNKEWTVERLIDMLIERQDIQVKKPSLSTPGKQIYFQAPPQLELATRPNLEKKISDLVPDGGEITVTATTLPFNLSLRVKYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QD28</accession>
    <name>A0A4Q9QD28_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein OS-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_911898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OS-9 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QD28"/>
    <dbReference type="STRING" id="114155.A0A4Q9QD28"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MRH" evidence="9">
        <location>
            <begin position="45"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU65702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="371" mass="41542" checksum="0C61D15B6F997EE9" modified="2019-07-31" version="1">MKLSPKSDFLCLIPPPPQENPVVEEPASEVATPVHSWSLLQPLSGTCLYHRQGWFTYSYCHNSHVRQFHELHHQHIPTTGEYKPEEDPEWEAYTLGRAPPTLETGAELTTAEAAAAANLELARGAGSRYLVQRWGDGTYCDKTGRKREVEIQFHCSMTMTDTILFVKETQTCHYVLHIATPRLCGEPGFKSRIDAEEEHVIRCREIVSAAELERVDNTLPPAAYPFKRPKPQKKVIAPPPPAPEERKDKDGAKKGSADGALHSDVLRRALQQLLAQRQGAQVGDQHVFVEQLPDGETEFLIEFVDVDLPEGEGGADDIFSDDNLHDRLQDVLRAAGYDIRGGKPAPDTRTHEPDDDAEAQEDRAKKHRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDB3</accession>
    <name>A0A4Q9QDB3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_984939</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDB3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="309" mass="34740" checksum="A2DC1B88FF803B03" modified="2019-07-31" version="1">MSTTAAGSDSSSTGEVTELVLEVLQYYETRRNLDVLTSARSQLSQYMGVAMLGVVFYEYLITFDLEVRYIWGRRLTWAKVVFLLNRYTTPVYYIGLVFPLLLPATRLRYATLPHAIKLTKIDVECSSFAGLRIYPISDKNRFITLAVVLLSLFPIATNMVAVIPLQLGIGHIPLPPHPTYCAFDDAMKSSEFHEPRLVGLLTNVPLILVEGIIVVVILLRTATVVLGRKELPTFKFTRLVMRDGIVYFLTLMLINVTNVATYFTDSTPYADFCTMISVYYFNLAGISDMSERTSIPSRWEGMATISLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDV8</accession>
    <name>A0A4Q9QDV8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_764174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDV8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10987" checksum="9A76DCED03D49F76" modified="2019-07-31" version="1" fragment="single">MTVTEFATLKLVYPHVWGSPEIQAFFATLSTQQGAWSGYPLRFFEDTTDPRLIYLITGWEGVAAHYEWIRSEQNQQLLERSKGLLEVEGVAHAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE83</accession>
    <name>A0A4Q9QE83_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_836448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QE83"/>
    <dbReference type="STRING" id="114155.A0A4Q9QE83"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="1">
        <location>
            <begin position="64"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="279" mass="30227" checksum="FC3A326AFB62B49D" modified="2019-07-31" version="1">MSTSEFYLSITPLKLSEIPSEDVIIKAGREVLNDTANWKHGKSFHKNTVKTLSRKKGPKDGAAWHARVSEHDKDEVTFEEFWDKLGKDKANNEMQYIPEIEKVQLIKQISQNQSVWTLFYKFPPPVSPRVFTVVQTIWFSETSPRTGIVVSVPVDVSGDPEAEKLEEKGVKGRYASVERILELDNGKVEWRMATSSTPGGNIPVFIAESSIPGSIANDVKHFLGWLKGVRGSKKADESATGDVAPAATAEVHAAAAEESAVPNAAAAEASAPGAAAGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K250</accession>
    <name>A0A4V2K250_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_302677</name>
        <name evidence="2" type="ORF">BD311DRAFT_745891</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143387">
        <property type="protein sequence ID" value="TBU35283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K250"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU35283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="117" mass="11597" checksum="C0C4B622205D1523" modified="2019-07-31" version="1">MSAALVLNEPTGQNPISSTPAALDSATARGVHDSPSSSSPAAEHVPPSTEKVAVAAAADSLSRPSDTDAQEGIAITGDDDKKDDDDDGDDWFPKGPPIRPTAHGTGGGGGVPKGVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K2F9</accession>
    <name>A0A4V2K2F9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_890372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145285">
        <property type="protein sequence ID" value="TBU51781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K2F9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23413" checksum="2EEED24C049FF5E5" modified="2019-07-31" version="1">MEHCTLSSETELQDILVLLPHLESLQIKRSARIPYPLPDQGQQTCHWPKLTRIEVPILHHGGVVLISEGDVLGIARYITLRSIEILTPPYNLVLLTEVLSHVRSTVLEEVVINIIVTDEFENGRLDWQEVLAELRDICSRADVLAAPSAFPSLGLVSLTFLHESAGVSGLDEDFREGLESCLPQCRQRGILRTSICQRTSFATLRRLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K3W7</accession>
    <name>A0A4V2K3W7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphatase regulatory subunit-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_826359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145173">
        <property type="protein sequence ID" value="TBU55191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K3W7"/>
    <dbReference type="STRING" id="114155.A0A4V2K3W7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000164">
        <property type="term" value="C:protein phosphatase type 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001069">
        <property type="term" value="F:glycogen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005979">
        <property type="term" value="P:regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2440">
        <property type="entry name" value="Carbohydrate binding type-21 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005036">
        <property type="entry name" value="CBM21_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038175">
        <property type="entry name" value="CBM21_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050782">
        <property type="entry name" value="PP1_regulatory_subunit_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307:SF36">
        <property type="entry name" value="GLYCOGEN-BINDING SUBUNIT 76A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12307">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03370">
        <property type="entry name" value="CBM_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51159">
        <property type="entry name" value="CBM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="667"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="802" mass="86290" checksum="F9DDE528E75ED7D5" modified="2019-07-31" version="1">MSTVVNLQTYTTRMDYTYSRHSNSAGAPLPHIPRRTSSSRSSVGLTAFQSTPSPPPATISRVLSADATYPAVVPIPTVLVVSPSPPQPQEPAATHEDEASSSSSSGSESYVQMYPRAKRTRTPRMQPFRSAADSTPTPAVLKARSNRQGAAFPVGSAASGDDTPRASTSFATPKPTLRVDVSDEKTPSTSLAAVARPSMVRTDSNRIVSAPHIDAAKSARKKSGEPLKSSLKSRRPVVRGDLSVVTGVSLTKSEPTTPVKSVHFDSRLEQVKLFLAEQKPLAISREGSPTDDTSGTESDFPSSIYGSKKDEDMMLTMTVTNMPAAPRADADIALEELKLSEDGLALNGRVRVRNIAFEKWVAVRFTVDYWQTTSEVTAKYLESTPGGVFDRFSFAIRLGDMLARIEEKTMYCALRYNVAGREIWDNNGGMNYKATFAKVPRPRPASPSTPTGNLSSLKSKLENVVNGQETVGSFMAQGTSGIRKSSSAFTLEASTSLAARYDFSASLRSPWTRSPPTSVTPTKSGHARNVTYPNTLSYFPKRGAMSKQAMVEDVRSSITRSPRLVQPDSPLEQLSASFYGASNASAEVADDSLVPIMSRRRSRNHQRGYFDIGLAQTGTEVKRTPPGTPVKERGARLSSENLALMAKAMEAGASERPTWFLERGGSEESTPSVTSNSESSLQSSPSGSPTDERVFGFGEARGAESESYSSFLNKYCYYTGNESSFLDVGQDVIHRSHSASSVEEFLSMSPSPSYMLSPGETPTRSPSYDDVASISSGSTTPTMRTAGFAGLMDSPSMVSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K4J3</accession>
    <name>A0A4V2K4J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K4J3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="228" mass="25722" checksum="9EEDF60418CCDC2E" modified="2019-07-31" version="1">MVGPALSNKAPKKGTKVNHIHDYFALHPCFDYQPGKCFIQEFRRLARKKNWQGDGFKRERRELGKAMIEQFGLVYGKDAGDLRSWQNLCSALRVSPIPSTIGKCREILNSLHVNLVDFIHRPNPEEPVRTFKDEVALSKYTLETGRTYPRNVVPKGSLLECLLRHILEPSKTRGLPSKTRGSGPPSKPRVPPAKLRGPPSKSRGQPSKPRGLTPKQNQTKRRSRKGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K837</accession>
    <name>A0A4V2K837_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_926803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K837"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="333" mass="36341" checksum="B594F707B8C82A15" modified="2019-07-31" version="1">MAAWFWDIYRFRRLSRLNEGSQPPLYATTERRVSVLSTPDTSPGAPLLSKVPTGSLRVLENSQPPTSPPSSPLRVDLALVPNRYQVSHPTTSDDLALDFRAVNGISPERRSTMTTVYTTTDTPSGPADSSLVLASHRNDIDTAQLVEPPSEGQQSPSVIRIVSRIHSPRASPVSATPAPSDYADTMSISSSTIPPSYHTDHSFPDLPSYPTTPLHPIDGLMQDPRAPPSAFTINRSRIQGPRSRTPSSSSRRNVRQSNPLPLLSTGQGDPFADGQQREDTRRPVVTRRHRQAVDGGVRLAGGTLDNHGVVGDEWDYHIDEIDTTALPDYGVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K870</accession>
    <name>A0A4V2K870_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1012664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145120">
        <property type="protein sequence ID" value="TBU58868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K870"/>
    <dbReference type="STRING" id="114155.A0A4V2K870"/>
    <dbReference type="OMA" id="VRFMQKV"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF27">
        <property type="entry name" value="PHO85 CYCLIN CLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="195"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="643" mass="71590" checksum="D3F4C3715D904357" modified="2019-07-31" version="1">MSTAPLLPIELVPHLSSWNDWRPPKSEAPLTPPLSSGPARRILVSQEQVPTVLPPISYFDRSFSRHSPVTPPPLDGYDQWDKYDAPSYQLPSVLAPPRSLEPSPSSSQYEPPEDPFVSATYTLDWFGSDSQRSSGYIAEKFCEMICYLWFSTISSTSASPSKRHRGAPTQPDSFSPHSNSSTAKLQFSVSPAFVRFMQKVLETTQVSHSVIVLSLHYICRLKARNPFTSGQAGSEYRVAIAALMLANKFVDDNTYTNKTWSEVSGIELGEVNRMEREFLLGLDFDLYVNKATYESWLKFLTGLVMNKEKDSKRWQRARCPARASHLHRPPCHRHAHLTPSRAPSHRARSTSPRRASICAVSHPVPAHYTPQHTHYAQYTPPPPSYAASPASTDGPLRSKRTAADAFSPTSASFSVAQLPPAQVPRRMHGLALDIPQPTAHSRESSASPLESLQSFSKLSLGASPVDARPSPAWPVRHDEYPRTLVSSYRIDDQRPPIQPQQLYFYSLAGSPLEYEEDRRNRKGRLRVHQAPPPSAPVYQYPPSMPMVVQSASTSPYEAHSHVAAPQLVLPPFSEVSQGLQHVNDVQVTERTQLPPIHVETQPQHTSSIPSAPFANAGPPGVHFYSTLTPDPAQHYYRVRGRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8P9</accession>
    <name>A0A4V2K8P9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_268878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8P9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021020317" evidence="2">
        <location>
            <begin position="18"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="19580" checksum="B185405C26703E06" modified="2019-07-31" version="1">MFAKLLSLAALAAAANAEHWIFGGSRPIVTTRLDSIVNPNAVRPPPRPRSITFARVGFARSTERVRAYLAPVSLLCRLVATFTPSSGRAVSRTCTMRTTSPRASARPSLCSPTSPTTGRPSCTIAISRLDSLARYLSQFSPASRRLSLHRRGDCAGLESRKSCGAIYMQRRRRRWFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K934</accession>
    <name>A0A4V2K934_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA stability protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_904287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the endosulfine family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K934"/>
    <dbReference type="STRING" id="114155.A0A4V2K934"/>
    <dbReference type="OMA" id="TNSNMTQ"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006760">
        <property type="entry name" value="Endosulphine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358">
        <property type="entry name" value="ENDOSULFINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10358:SF6">
        <property type="entry name" value="ENDOSULFINE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04667">
        <property type="entry name" value="Endosulfine"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="133" mass="14383" checksum="CE1B2C224CE43E33" modified="2019-07-31" version="1">MLPAKRNKVDISKLTEEEQKLFRLYGKLPTHKNVLTKMQKDRKYFDSGDYALSKAGKAPQNTVGTAIPNPENIPHATSPPVHQSLSVSPTNSVSNAAAPTKESPLAEAPQPEEEGAESVETKDETTAIVEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9G0</accession>
    <name>A0A4V2K9G0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_915753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9G0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6625" checksum="13C7108B9993AD60" modified="2019-07-31" version="1">MMAPASPATVIYVFHKLQALLRLTSIICPPIFVRFRGAERELWGCHVPSTYVKGVLQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9T7</accession>
    <name>A0A4V2K9T7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="17" type="ORF">BD310DRAFT_839076</name>
        <name evidence="16" type="ORF">BD311DRAFT_701075</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">CBS 464.89</strain>
            <strain evidence="16">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="ML143468">
        <property type="protein sequence ID" value="TBU25058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9T7"/>
    <dbReference type="STRING" id="114155.A0A4V2K9T7"/>
    <dbReference type="OMA" id="TCASRDW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5041023175" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041023176" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="778"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="79"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="358"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="633"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="691"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="777"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU25058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU65188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="828" mass="92154" checksum="C38EF51C98A47465" modified="2019-07-31" version="1">MFPKRSSTARSLSVDSVTTITTNPSGGSGTTTAASSTGVLTAPSSGATTPLTSGTAPGAVARPPMSQQKSKFRKSWIARNKDFNFSAANDIMGIVMLEIQGAKDLPKLKNMTRMGWDMDPFVVVSFGKKVFRTRVIRHSLNPQWDEKMLFHVRRYETTFKVQLTVLDWDKLSSNDHVGDASFDVAKLLADAPKKDENTGLYPDEEDGRRSMTDFTLPLSTAKEMPWEAKHNPTISIRAKYQPYDALRQKFWRVYLKQYDTDDTGTISHLELTSMLDSLGSTLSHDTVNSFWTRFNKRPQEDVLSINEAIQCLETELCRPASEKKRIDPDEGIMDTSAPVTPAVMSGLQAQQNVDFDQLDFSGVPSNHAALSSEREPADNLPNALPAHPTEPMQQPLDAAAQGLSTTPPNRPPYIRSNASSDAEESSNGSNGSPDPFVERVINIKNCPLCHRPRMNSKAEVDIVTHLAVCASQDWARVDKIVVGNYVTANQAQRKWYTKVISKVSAGNYKLGANSANIIVQNRLTGQLEEEKMQVYVRLGIRLLYKGWKSRMEGARARRLLKSLSIKQGLKYDSPESARDIPAFIAFHKLNIDEILDPLDSFKTFNEFFYRKLKPGARPVECPDDPYRLVSGADCRLMVFATVSEATKLWIKGRDFSVARLLGDAYRNEAEKYNGGALCIFRLAPQDYHRFHVPVDGKIGPMTYITGEYYTVNPQAIRTALDVYGENVRKIVPIDSPQFGRVMCVCIGAMMVGSIYTTVKEGDYVKRGDEFGYFAFGGSTIVVLFEKGVVEWDEDLLINSRACLETLVRVGMGLGRSKRKLVTDGNGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MB87</accession>
    <name>A0A4Q9MB87_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_936560</name>
        <name evidence="1" type="ORF">BD311DRAFT_766547</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143479">
        <property type="protein sequence ID" value="TBU24475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145196">
        <property type="protein sequence ID" value="TBU54124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MB87"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU24475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="77" mass="8785" checksum="0DE585C6DAB01911" modified="2019-07-31" version="1">MVEYTKSRMLRQTCPRQCRNGAGSIEAPCSRDEVHGPSKDAHGMVVRPSSMRMRSRGRLSCRRSLRCCCPAVDRPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MQ05</accession>
    <name>A0A4Q9MQ05_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_806490</name>
        <name evidence="2" type="ORF">BD311DRAFT_777496</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143412">
        <property type="protein sequence ID" value="TBU29605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MQ05"/>
    <dbReference type="STRING" id="114155.A0A4Q9MQ05"/>
    <dbReference type="OMA" id="HQIGDYW"/>
    <dbReference type="OrthoDB" id="10259681at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15465">
        <property type="entry name" value="bS6_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_bS6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS6M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="Ribosomal protein S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU29605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU64507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="115" mass="13573" checksum="BD48C03FD55CAC94" modified="2019-07-31" version="1">MPFYQLVCIAAHYPEYKHIKDLVTRVASHVLKEGGVVRKLDSWGTCTLPQRMRRNKQYHTIGDYWTMQFDASPTTLRGLNTIMRHDPRVIRWTNLKIGEKVTDVRQFVEKTVDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N970</accession>
    <name>A0A4Q9N970_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145259">
        <property type="protein sequence ID" value="TBU52252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N970"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6633" checksum="6A4E937897781488" modified="2019-07-31" version="1">MVRCTPIVAATVTPRLHDRACVRPLRRCGSIAQWDDATHRGVRGVYDVAGSFPGLGLRGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHS5</accession>
    <name>A0A4Q9NHS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_384234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHS5"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHS5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="446" mass="46061" checksum="9249ECDB72ECCF75" modified="2019-07-31" version="1">MSDLITVDDLAFDEITYIDVDDNNFWNPFFPPNDPNVRQGEVRMGASTGLSATFTFTGSQVSVFGRVQPALNGSQQPLSLYSVGSQHLQAFVAPDVTTAQDNVAFFNSSVMPYNQYTLIINVSRASASAPYFLDYIQYNTSNPDAGPTSAPSSTSTTSSTSSTGSGTPLSGSSGSSSLSAPVGAIVGGVVGGIAVIAAAVFAFVWYRLRERSTRKHAGASDEGKFSPPSGITPYIVPSLAHSQGRFADFDEPPNALGPSGSIFVGQHGSSHSLGYHGESGRPNKAALARALYQSSPSPGSLSTYRDDSAQDATWGAQSVSGTGTGSGSEGHQAQSVLSRSAHTPSPRSTVPDLPNPANPPAHSGTRAKGARFEPWGPRPPGSRPATPTSPGPPPVQEDSGVRFQPGLTPSNVAPVLPPGVIPGPIRSAATGSEVARADIPPAYTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NMJ7</accession>
    <name>A0A4Q9NMJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_962864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145276">
        <property type="protein sequence ID" value="TBU51934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NMJ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="221" mass="24358" checksum="FB04F1BD14D83A6A" modified="2019-07-31" version="1">MPHGARHLPPRWHGQARGHLPPLTSAAPQALCRLPQHFPVRPNLVRSATVSEDACVQSPIRIQRRPNKNAGTQSQQLRRPPTDVPRPCGLDVCVPRFPSGSWHALLLLLLLSSDRENHDRGERQQQLLRGGGNANVTVRERAAGRRGARLSDRAGRQTSLHRRRARRSDSRPTADGGVHDQPGVEGLEAALASTVDKLMRGARCAAGDGRYREERDRRSGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQ60</accession>
    <name>A0A4Q9NQ60_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 11">Triosephosphate isomerase</fullName>
            <ecNumber evidence="6 11">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_968154</name>
        <name evidence="12" type="ORF">BD311DRAFT_703666</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="6 11"/>
    <dbReference type="EMBL" id="ML143501">
        <property type="protein sequence ID" value="TBU23583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQ60"/>
    <dbReference type="STRING" id="114155.A0A4Q9NQ60"/>
    <dbReference type="OMA" id="NWKMHMT"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000025">
        <property type="entry name" value="Triosephosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF41">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="10 11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU23583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU57406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="251" mass="26775" checksum="215E45D9B60A6EB8" modified="2019-07-31" version="1">MGRNFFVGGNFKLNPTTRAAKQALVKTLNEATVDPSVEVVIAPPALYVIPLRASLRADFKVAAQNCYEKSSGAFTGEISPEQLVDAEISHVILGHSERRTLFHETSEQVAAKTRAAISAGLSVILCVGETDKEREAGQTKQVVESQLQPVIQVLNEADWSKVVIAYEPVWAIGTGKVATSAQAQEAHADIRAFLSSQVSPSVAENTRIIYGGSVNAGNCKELAAQKDVDGFLVGGASLKPEFIDIINAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NQK0</accession>
    <name>A0A4Q9NQK0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_959851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145142">
        <property type="protein sequence ID" value="TBU57082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NQK0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NQK0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU57082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="168" mass="17918" checksum="304DB8FCC4243C45" modified="2019-07-31" version="1">MSTSTEVSKWRHLPPPPGFASTVSFSKSSGKAVAAATASTASYEELKSKRAWDLAFSPAKSLPMQAFMLYMSGGGVQIFSMGIVFMLLSSPFKNLAAINTAFAPFAPASAPPKSLTTLPLQKIAYLLCNLLTLALGLWKCRSMGLLPTGTGDWLAFETRGQPPEILLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTS3</accession>
    <name>A0A4Q9NTS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BD310DRAFT_783608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTS3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="96" mass="10715" checksum="B6E290B7A1328306" modified="2019-07-31" version="1" fragment="single">VALLLYDSLLMCHREVRHMWSRGHIGTTIIYTGARYSSLVNRLVVVLVLSRWKGQITESIPAFSALRAYAMSGKRSWVLVVMILLGSVAPATEAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWN6</accession>
    <name>A0A4Q9NWN6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_907216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWN6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5043702915" evidence="3">
        <location>
            <begin position="26"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="447" mass="46266" checksum="17093CE775228FBA" modified="2019-07-31" version="1">MVWWTAFTLGTASLIPTLWVQFANAGNTTCASSQLDWYTSVVGESPCVTYQRLRQICNNDYQVPTFRTNTPGDQCDDQVASCCCNTVAFQLSMLCMNCQYDTQPGDQIGIDAGVGAYTLYRQTCGAGTNHSLPDDIQSAVCNLNIRLDNYLYGGWDDGSCVWTKENADRDHAANNNNTFTHCANQISPSSTPTSTSSSSSSAAPATTTISSQSTSTSSSGAPAQTGADNNASGSHSSHNNIGPIVGGVLGGIGAVAAVVGALVFWRIRRDPSGATPATPDPHYSYGYQDNPPMGSATPFAASIGAMSPGSEAFASGGTVVGEPYPGFGAGSAIWSQVSHSIIPPSTLSPDESLRHDDAGPIAELSRSPSGRLPPAYRSWEQATGTGSNCGSASVPGTGSAGGSAYSETQPFGVLSPTGSSSVASPSPQEFDPHVPLVPLRRSSIAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NXS3</accession>
    <name>A0A4Q9NXS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_727410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145181">
        <property type="protein sequence ID" value="TBU54769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NXS3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="103" mass="11497" checksum="B5E8AA964D194570" modified="2019-07-31" version="1">MPSSRHDFRALTLMLVTIFARPPALPASHTAFLSSPVSILFRHEDSRLWALLRPRRPHSHVFVCFEFACPSRASLIPPAGPCALLPFRDSSAQCSSWAIARSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NY21</accession>
    <name>A0A4Q9NY21_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_915071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NY21"/>
    <dbReference type="STRING" id="114155.A0A4Q9NY21"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049633">
        <property type="entry name" value="Ribosomal_eL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01170">
        <property type="entry name" value="RIBOSOMAL_L6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU63951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="238" mass="26010" checksum="1368389B446FB9A4" modified="2019-07-31" version="1">MARSKEIAPGVGRLSRSAVYARRGLFKGQKKTEKPAAAETPATKEVSVGGEKNGSTRIVPTKKAPRFYPAEDVRQPKKSRKSPKPAKLRSSITPGTVLILLAGRFRGKRVVFLKQLASGLLLVTGPYKVNGVPLRRVNQAYVIATSTKLDLGDFKVDEKINDAYFAKPATKGSRSAEEEFFSEGKPKEKTPFPESKAADQKAVDGAVIAAIKKTEYLEKYVKATFGLSKGQFPHQLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1U2</accession>
    <name>A0A4Q9P1U2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_977971</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1U2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="89" mass="10160" checksum="753F2C472B5F1950" modified="2019-07-31" version="1">MDLDVPLTPPLRIHTIRVQQISSEVAQKRLDSFLHRFRTRSLAKNSGETTTSVQLQKLADALNEEHTHIREVTDSRLARAECSHTWGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P6J0</accession>
    <name>A0A4Q9P6J0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_811569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P6J0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="19452" checksum="283F28B95A4DCD31" modified="2019-07-31" version="1">MKYYPVPNLDPPEPVEVAVKWVRGQRAIDSLRREVLMYDGPLADLQGTVVPIFGGFFTGTVQEGYHVGCLILEWCPQNDHTTFGKPTEEELRLRMHAVHKLHAAGVYHGQLYERSDSLCMSDGRHFLRAADGTMRIVDFQHAYRHSEFALASMHHQAALEGTLRDIPWNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9R2</accession>
    <name>A0A4Q9P9R2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1006428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145329">
        <property type="protein sequence ID" value="TBU51399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9R2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="104" mass="11593" checksum="275F06E4275910CA" modified="2019-07-31" version="1" fragment="single">GKCCGAHALSLATATPLAQSPALQPHNRVFQTHDDPREMQPDTSHIHRATECISGRNVNRGHRQNLQNCLHPSMSSHFREYLASVCPYTGHPPCLRSLRSLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PA35</accession>
    <name>A0A4Q9PA35_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_948048</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PA35"/>
    <dbReference type="STRING" id="114155.A0A4Q9PA35"/>
    <dbReference type="OMA" id="TTVCCEN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="108" mass="10244" checksum="E1E42408FB00BCEA" modified="2019-07-31" version="1">MPGGSPPASPTKTVTFTAPAASSTSAGSCSTGAIQCCHSVQSASDPAASLLLGLLGIVVQGVDVLVGLTCSPITVIGVGGGECSATAVCCQDNSHGGLISVGCLPISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PB71</accession>
    <name>A0A4Q9PB71_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type E3 ubiquitin transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_1043628</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145358">
        <property type="protein sequence ID" value="TBU51225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PB71"/>
    <dbReference type="STRING" id="114155.A0A4Q9PB71"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="8">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="758"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="173"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU51225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="816" mass="91303" checksum="F67B917AE8686051" modified="2019-07-31" version="1">MATTNAMSASSTSTTRATVPAPISVKTCRFYSQGKCNFGTKCRFSHERPSQNVAPPLLSPKPAPKANKPKFERGTQPCFAWEKTGACTRGEESWYAHDPAICQALEQERVRQAMLAQEAGLHRALENACVESEHPREAASAERQHQDVAMMERVLNGSIAVRGQLEHAHQAQARLAQESGRIAEEELARMERERAYLAQLAEEEEARRRRAEGEERLERERAHRARLAEEDAARRRELEAAAEERFQARATEEAVVTLQRVILGSIVTFAAGLEVRAVLTGFECCAVKIKNLPADTREDEVTEFITQQGIDPARFQLVGVKMVHDGKKEADVVTAADLADLLSCGPDGIEFKGERIELQIGAYNIPGGMGASSVRDDDVLTVSWRAPSIRYIAEYDDYARAQERAREPDRKMYAERRLHVEMNTLPPGRTIKGFNPNSIKIYNLPASIIEDELMLFTQTSLVRPLLQKGRSVCSPPELAFQQLLREIERVSPRNVVHHEQSTRERGKDVDGIVSYRIRFTSPEEARVVYEGLSGRIFPAISPIALWLRLPEPMCFNLTLPKEQYGAQRALWDALVNSATDRRACVLFVKPDGNVVRVRLSGNAKQAVGMLKVRVENLARGEPLVGWHRSLGFFNNPFPRRVLDETGAYLRSDWRRQVLRVYGEPRAVERAREMVKAELERLEGLDFTVTLKEVSVAFFVRQGIATLKELIGEDAVTFHPWARRITICGGEEARHHLSRLIDESLRGGVSIAQDGELQCPICFDDVSAAYRLGCGHSYCSACLRHFLTSAVEGGDQFPLACMADEGRCGRPIALPTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBD9</accession>
    <name>A0A4Q9PBD9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BD310DRAFT_263690</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="ML145271">
        <property type="protein sequence ID" value="TBU52019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBD9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBD9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF10">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044272963" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="17">
        <location>
            <begin position="20"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="20"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="241"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="258"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="TBU52019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="341" mass="35450" checksum="D8130FE48C93AAF5" modified="2019-07-31" version="1">MKRFAVFAAVSAAVPYVAAHGFVSQVIIDGQAYEGNVPNDHQGPSPIRLVSDISPVKGATNKDLFCGLNAALAEMVVPANPGSNVTFQWSGGAGQKWPHNTGPLMTYMASCGSTSCDKFDSLDAEWFKIDEAGKKDADTWIQQDIMNGDSYTLTLPENLSPGGYLIRHEIIALHLAVTEGGAEFYPSCTQVQVGGNGNGQPNQTVNFPGAYKDDDPGIFDPSVFDSGATYVFPGPPISNLASNQEEVTPEVSSVPFPSGTAVSAGTGTGKTSGPSATQSSAPSASATGSSGNSGSSGFSPSSGSNAQCRLKKPSASNSSDLFVVRPRHLSRVMARLLHHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCW7</accession>
    <name>A0A4Q9PCW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_229186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145249">
        <property type="protein sequence ID" value="TBU52468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCW7"/>
    <dbReference type="Proteomes" id="UP000292082">
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        <source>
            <dbReference type="EMBL" id="TBU52468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="189" mass="21270" checksum="9BCEFEC67E42615B" modified="2019-07-31" version="1">MTTQASAVVSHDIRVVLRHRLVPRVLPHYEVSCSGMPMAEKCLRCSRLTWRRFTPSPGLWTAASLDRARMTIDCPYPGWIDLRRLLPLSSLTFVPLFGCSDTMENSSGITRHRCPQAPGSDIIGTAHILRRHHQQTPGSTLVTQQFLVESEPRSSKYRLALTSSFSFSLPSPNIYFRGFAFGKLLIIQV</sequence>
</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        </location>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PE30</accession>
    <name>A0A4Q9PE30_9APHY</name>
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    </protein>
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    </gene>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
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    <dbReference type="STRING" id="114155.A0A4Q9PE30"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
    </evidence>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
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    <sequence length="116" mass="12280" checksum="2CD5425C7B28242F" modified="2019-07-31" version="1">MHPVLALLAALTPTFAFLITEPSSTTVWAADGPNTIAWTKVSTDSENVTVVLNNQQLKPPVSQVLLAFVDSTVGSIVVTQAPPGGFHPGSGYVVYFAPDTHTTGTRLSISQQFRIA</sequence>
</entry>
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                <person name="Ng V."/>
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                <person name="Hilden K.S."/>
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            <begin position="1"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU51362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6756" checksum="2EA3A2D627C1181C" modified="2019-07-31" version="1">MSTVLAQTRTLASDHSAPAPGQGNVRKPLEGSAWQNGLMHLTKVIKIRSMLISLVNWMSVLL</sequence>
</entry>
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    <protein>
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            <fullName evidence="2">Uncharacterized protein</fullName>
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    </protein>
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        <name evidence="2" type="ORF">BD310DRAFT_910549</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145299">
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    </feature>
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        <location>
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        </location>
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        </location>
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            <begin position="149"/>
            <end position="169"/>
        </location>
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        <location>
            <begin position="1"/>
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        </location>
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            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="20179" checksum="193A89357383A123" modified="2019-07-31" version="1">MNTESASPAYEEPSSSGNTSRTQGLHALSSGIASLEHPSKRMRLEDLTPNIQTHNRFAFLAIEESDENYEQSSSGSETDEDAGVADADPMLHEEVTNVLARKTVPEPSRKKTARSSGKRSNHSTARAAVKHAVTGWSLKRKHAEVENCDPLIPAPSQPESPNTLSSQTSVGVGAVAPAVLIAPSPASCHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG14</accession>
    <name>A0A4Q9PG14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_910746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145342">
        <property type="protein sequence ID" value="TBU51306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG14"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19866" checksum="4B44DB8F2E9A0398" modified="2019-07-31" version="1">MQAARNFRNTKKKGQQYRTSAPKVNKKRWTRADQHTRADIPKVQSPIQHEPISVAISESSSIARKLVPQLKLTLTFADTQDNKGFPKQTSGTAQVISNGLTVQITIERESTPWQKDHSQGLLHSEASTSEDNSTLPEGTTLDKEWPKKSKRSWMQGRSLNQKLTVKKHCVICGQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGP4</accession>
    <name>A0A4Q9PGP4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1043003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145247">
        <property type="protein sequence ID" value="TBU52537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGP4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="3">
        <location>
            <begin position="174"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="322" mass="35362" checksum="0F44338C2BB708A7" modified="2019-07-31" version="1">MSLLSLDERSAQVLQVGLPGAFGTFMIGSFLGILLYGVSTHQAYRYIRSFPTDAAYIRLLVILVMILETLYVIFNIHTCFHFLIWNYAHPEGLKHSTWSLDILPMLTGLVVVVAQIFFVRRVSLVGPRHRILARIVAGALVGELGFSIAATVLSFIGRPALVSVLSAAALLIASIADTILMLALVHAIRTSRSRESREASESPLDVAQVYIINSGIITGIFHYLAFITAITLPSGSLLWGAFVILAVRLYANTLLAVLNSRDLRGMEFFMSVSFSSVTLEGAHFADESDLWNTPKEKRPRAVTLGRNPPQFTDPWASATRNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGU4</accession>
    <name>A0A4Q9PGU4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_953065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145283">
        <property type="protein sequence ID" value="TBU51816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGU4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGU4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="381" mass="43564" checksum="97E0CAD1557BAA74" modified="2019-07-31" version="1">MDIVVRMQHYEQDQWDLRHVLFAHEGGVDRSDQLLRSRQLTNLQTYVDDLKHEIRRIKSSDNSDDVRANLTYLLMESVKPIDSLKPEEEEPGEDHVRHREDFPNIKFFTARDWTEYKRDNKKSTRIGEPVIRGKAKSSLGENHTALYLERTDGQPADGDYVNDARKFARTLINLALTSKYKMPRKWSEADIWFQELFYTALRKRFPLFQLCHNNAKGNFFMTQAYYEAVTRKWENIRPQNLDLENAKYTIKSHSASGEDDDETVDVRDTTKASKPTTKRPPTTVITPPRPAKAARTQGQDAEPELSRQTPGKGKGCAGPSLLAIMATSAYDMSSYTMFAATHVPCPTQNRRPARTARAKYHVGPRLGSRGSRNVHCGYGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHW3</accession>
    <name>A0A4Q9PHW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_830224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145215">
        <property type="protein sequence ID" value="TBU53422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHW3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="309" mass="34503" checksum="E1BCEF6F49444B5C" modified="2019-07-31" version="1">MSSNTADTELLLFPTVDSELLQSTLSAPPFVIVEGIFNIRDFGAGYATSLGDARVKPLFLFRSGEPSGITPKGIEQFKSYGIKKVFDLRADVEIRKYNTVMPQIEGVEIVRSLISEEALDPVEIADQLKEFSEDEAVIMQLLGVSDEDIVHDYVLTRIGLQPAFPLLALRFQKEDVFRKNWKGVISLGTANSHNHLQHAILTALHRSHTPSIPPNRIQSSFMSSNASEAVWKGDFTGDLKERIIRFSDILTYAEGFAHSASSQLKLKEVAIFKRDQDGKTQCKVTYETTVDESAYCLSLGVCLAKFFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHX0</accession>
    <name>A0A4Q9PHX0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_860002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHX0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="162" mass="19020" checksum="613B9DB4B1713430" modified="2019-07-31" version="1" fragment="single">LPWEVIEKVIDHSSEHTRALCNLALTCRQLHPRSSLVLFNHVQLERRQQLFVFCDVLQAQPNFRSIVRSLTIRLEEFSPFPLLSILPDLRSITFFGYKNFPRPRRFTSIHGSTLHCCRQFGRGLRSLTFRGVRFRHCTAFVRFITAFSGLQDLVCDDVQIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIC7</accession>
    <name>A0A4Q9PIC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_887102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIC7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="5">
        <location>
            <begin position="143"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU53861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="403" mass="44202" checksum="FEE969DE79D0B200" modified="2019-07-31" version="1">MAQSTILDKQPAKSLYLAYFVSSLIICKLPFWSVRYARPSQRPRPTWTWKRTMIIRTMQELFSCKVKVKIGFGRDPLSAVPDSSLTDAKFVWVEGIDEPLYCGEIRRLGDITGVRPARIPGYWLLKKGAVWDGPKAKPGEKTVLHLHGGAFYIGSANPSDITANFTRGLLEHSQSLDRVLAIDYRLTASAPNPPANPFPAALLDSLAGYRYLVQDAGFAPENITIAGDSAGGNLAIALVRHLVENPFPSLPPPGRILTVSGWFDLSMSRVGPGSSHLLNSASDIFGPLKPGRLFGEYGMTSLRGPLDFEVVKTNRYLSPSSLDCEPMKGKGLFEGFPETYVAAGGAERALDESTALVERMKADGVTVVEDFPPDATHDFVVFKWQEPERTEALARMSAWLDGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIJ7</accession>
    <name>A0A4Q9PIJ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_133374</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145207">
        <property type="protein sequence ID" value="TBU53676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIJ7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIJ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="448"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="571"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="580"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU53676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="619" mass="69095" checksum="49E3C6D00F86E36F" modified="2019-07-31" version="1">MDAVAIMQTVQTILSAVQSGSTNLNISEVIAATNATLPSSAEGAPSFSPFQLIHKLLTVSAVRDWLKLLLVGSILEVCRRFLWRSWESIMHYFWITVTLDEGDDAGYWLMFWLSKHRVFRTARTLDVSTRSFGIDSPVVSDTRDMDDISKGRRISFLPSLDTTYALWYKYRYLTVTRSQTTDSPWHKTTNLQIRMLTRNHELLRDLLLEAKKMYYNASENLISIYVSDSSDYWKLMSTQHKRPMKSIILDPGVIELVLNDAKDFLASKEWYAERGIPHRRGYLLYGAPGAGKTSLIHTIAGELNLDVYIISLTRMGMDDASLNATIAELPSQCIVLIEDIDAAFHQGIKRDIVDPERQRPEDQEQDPQKSEKEKTTDSACRVTLSGLLNALDGIGAQEGRIFFATTNDHKALDPALCRPGRLDLHIEFKLASKYQCRELFRRFYLPSSADDDKMDENEEDVDEKDSGYGSRSESVKGDNEPASSSPTSTPSPSRADADSDSLATYTGLTHSARAPKLSRKQAAELADRFAAAISNRAFSMATLQGYLMTYKTRPYDAVDDVPAWIEKKQLENKVGARSDAPAIKSEASPSPAPSAASSAQVEEHETAQEHCSTSNLPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIZ7</accession>
    <name>A0A4Q9PIZ7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_767468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145198">
        <property type="protein sequence ID" value="TBU54044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIZ7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="57" mass="6334" checksum="70C717034F7CF3D8" modified="2019-07-31" version="1" fragment="single">AKRGRCDLDAFVPTATGVPFGVTYEKIGTIQRRLAWPLHKDDTLSRSGRPTGLNVFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJT4</accession>
    <name>A0A4Q9PJT4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_858666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJT4"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJT4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="27"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="325" mass="37460" checksum="DAB0B30F7746492B" modified="2019-07-31" version="1">MDNGTPENLRQAFVEAGNLYLWQIHRYIQVASFVVLVLEMLETLPDEIDLIWPTNTSVMKAVYLVNKYSPFVDFLLLVLVDFASRSPSSCDLRFKVLVYCYLTGTLFSEFILIVRTYALWACDRHMLYYIIFVALMMIPHAYYVSYDMLEQNSANFSAAKLVVRIFGCMPPIQDEGTWPAFTYLICAETMVVIMTLFKRYLDPVALNEHQSYTSMMLRTMYRDGTCFWAIVLALSGVNMLMMFLAPRELSYSMQMPLRTVHSALCTRVLLNLRKVAAKASPTQQDLDFLSTLALEPFPEYSATEESDDSMPHTEDFELQEILHQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJV2</accession>
    <name>A0A4Q9PJV2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_936002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJV2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="320" mass="35375" checksum="7D957C51569E357C" modified="2019-07-31" version="1">MADNPDVQVASENFFQNCWTFAALTLFFYDCILTFDCEVTLFWKGVHLSGATILFLLNRYITLATQLITNVSVPSPSVESVFSGDVATTVLDSLQYIPWAAFSALRTYALCPDPYRWLLSASVFALSLVPIVTIMWGNIYRLSVVNDPVLGLIPINAISASKNMKLEVVTRSCMIASDLVVLCVTWVRTYETAKLSLRSLGKRTLTSILLLDGMCYRALLVLSTLQMTFTLTGVDENANFPTSVIVYMEEPLTSILTSRFLIDLQKAQRKLAGSSQSVSFGDLAFQPQTSGNTSRFIGSLGAQLSFHKVDEEENEVEDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKF2</accession>
    <name>A0A4Q9PKF2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">High nitrogen upregulated cytochrome P450 monooxygenase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_935569</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145185">
        <property type="protein sequence ID" value="TBU54594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKF2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PKF2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU54594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="573" mass="63633" checksum="EFD72D38746AC709" modified="2019-07-31" version="1">MSATSSQMQTATLAIASALVAHQIFRRYETFSIPVHAALLLGFPALVAASLVSRPLALDDEFAHVFRSSLSTYLATLALSIVVYRLSPFHPLAAYPGPWWAKISMLCTALVASTGTRSKRVRRLHDVYGDVFRIGPNELSIRDTSAIQAIAGPSGLPKGTDWIGGMLRDHNLPLIAIRDTDEHLRRRRAWNRGLGPNALREYEHVLARRARLLVKGLEERAKKGEEVDLGRWFNWFGYDFMSDMAFGGGSELLREGDKNNVWAVLEKGMALGMFLAHLPWLGVYIGHIPGAAWPLQSLLAHGEKAAAKRLARGSTTSDLFHYLNNENLPEKPSPAPRQLYDDGVLAVVAGSDTTSSALTSVFNCLLTHPETYAKLQEEVDRFYPTGEDAFSMKHHRDMHYLQAVIYEALRLFPPVASGGSRRLPDNARGITVGSVYIPPGTVVRLPPWSIQRDPRNFTFPDAFWPERWLIASGHVALADAPLPSSPSADGTELEKENGFVHNEHAFIAFSHGPMNCPGKALALQEMRVVTVALVQRFRARLRAGWDPQFYEREIRDYFAATRPCVPVILEARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKP2</accession>
    <name>A0A4Q9PKP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_729978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKP2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7114" checksum="5025B931A219D685" modified="2019-07-31" version="1">MISMYTLPMAGMCLCSSVVVSIPNKYSLSFSTHQPLLGMSHNPALPCIAMKLKVDILPAITRGMVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLC4</accession>
    <name>A0A4Q9PLC4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_826839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU54993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLC4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="392" mass="44293" checksum="D357512FF125C376" modified="2019-07-31" version="1">MPPPNIAASFGVALLSSPRWCLRHIRHTPHWPGKWPTVSQARQLTTGSRELEGDSSHPERTRQSRRVCTLDPTKLAPSDYVDFRARNNPSVTFVAQSYDPSNTLLGRPGTRIIARGFRHFKFPPNTAGFLYYHIPPYSPPLAGEVRFRVTFSPDPASFTQGYDLLMDYGVRWNIPLLYMTDKKEYTGLHTLLLQDGLVTPQLSDIAASAVEGLKKTAHGRKISFRRTALVSSFRRGFHFRVGQHNRYCIAIGTDTVVKKRVENLANFRVPVDGIGESAQYSPFEGSTICCFEPSTLPEHAGKRVVVLRVLRLLDSDPIRPVPPPNKHEYPLSALRPREGQLLMTMRRGKVQPWSVDVNKDTKRPATHVGMGRMLRILYENQELYGSPPEPFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLC9</accession>
    <name>A0A4Q9PLC9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_934622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU54999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLC9"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020894498" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="9700" checksum="EF1F512B3C684D95" modified="2019-07-31" version="1">MSTILCVLAGARLLLGAGPVLIELTLQLVSEVGGPDNCESIESLDIADNTNNNGGVREENGEKSVLVMLLRGFILYRFHGGVLLGRVDMAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLF3</accession>
    <name>A0A4Q9PLF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_719748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU55017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLF3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="94" mass="10708" checksum="15722FE00D4446DA" modified="2019-07-31" version="1">MSLLVSSRVAARVASLPPELVVACFHTSAPFNEQSRFDVRSVHPDLPLFWRHRREDICPSEHCLAPSRNLSRLHHSWLSLSGWPERGQLDPRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMF4</accession>
    <name>A0A4Q9PMF4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_950798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145169">
        <property type="protein sequence ID" value="TBU55412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMF4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7292" checksum="BB32D21D399D1799" modified="2019-07-31" version="1">MTLEQWSTKETIGKPEKVGSKRGSDCLSVLTQVLPTDSELADPLAYRRDDETGLQIREAMKIELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMX1</accession>
    <name>A0A4Q9PMX1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_682149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145167">
        <property type="protein sequence ID" value="TBU55515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMX1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PMX1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="511"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="796" mass="84033" checksum="27A363929C45329E" modified="2019-07-31" version="1">MQGEMSRYTTSSNPLPRPPEHIPLVTSLSREAPAPAAHSAQRSTAPLGLGLPTTVAPSSQSRTSSNGSNGSTGSRHRAPSVHFADPGPSNDREQKSRYKGTADGEELRQEKTRRPHLIVPGAPYSQRVIPPRLEGSDIDVTPRPLISAVPTSQRPIPQPVYYPAGAPSAPRVTDTLIWINGIDPPRELTTSEKQALPQLREHSMGYTNSNPVSSTVVPSVAPSSSAVQPPVQPPPVIPPPPMMQPTLAARPAAETGSARVRITAPDPPIDGRDRHALRQGPANKEGYVKAYLPHMGGIGWIREEEAAKLPVRARGTESRYPYVIAKELSEVDDDWRRDGGTSAHNPLQLSGMPEAPMASSSRSAVQQGQYNALPESFTAASTLFRNPPSSSDRAAPASANSSSTSLSGMPILTAPSSTLRTSSGRRRAASNAESLGLNLTSLPMPPAPQTSGEPPATPSAASSWGTMESRNNSLGDLQLNNFRDPNPYTRAESLEQLPIGELNGGPIVLTDTITPRQGSSILDDDRSVSGRSIASRDHHAGASAPAGLLLNPSSGSSRVVGSLQDLEEVNRSLQQLAESQSRESSRHHSRQPSGHSSLSRDESGVMVGSRTGLALYSSRPSQPSSNNASSGPSPDDQSPPADSRPRSGASTRSHAESTYSHQSSHSHHSSYSAHTSASHRSSSDNRKARRASNASLLNGAPEHVATWTPMPSDMQSYGSSRGPYVSESRPPPSQESIPRSLQSNGDGLGLTFEAPSTSSAVTGSGEQAAGIHAPRPVNGRRASQLIGGTWNARSGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN51</accession>
    <name>A0A4Q9PN51_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_671605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145164">
        <property type="protein sequence ID" value="TBU55667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN51"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="109" mass="12406" checksum="2DDA25CFBCD7D5E3" modified="2019-07-31" version="1">MSDMSMARFRRSQHCPYIHVSILQLPARLTRLSPPTLIAHPPNILSTDHPLFSQPSRHLPYPLFLFLSPFVLTVLFCPMSTTPSLSKSTALTLHPRSLTRSPRFPSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PN69</accession>
    <name>A0A4Q9PN69_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_933273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145165">
        <property type="protein sequence ID" value="TBU55646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PN69"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="59" mass="6567" checksum="2CB59C524ABAD26A" modified="2019-07-31" version="1">MGSASSPLCHGPHKSSCRRSPSCPSVHRAHIERRRRATIVVTVCLFVNPIYTHSRVTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNB6</accession>
    <name>A0A4Q9PNB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_932979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNB6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5931" checksum="91336F51E791E3CF" modified="2019-07-31" version="1">MPTLIEKLSVKQSLAEARTVAERWHGSPAVSAHMTDLQGMFSKTIVVEMEDGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNW8</accession>
    <name>A0A4Q9PNW8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_932401</name>
        <name evidence="9" type="ORF">BD311DRAFT_767834</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="ML143495">
        <property type="protein sequence ID" value="TBU23778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU56009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNW8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNW8"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="110"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU23778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="35317" checksum="C25D76A483F4FB3B" modified="2019-07-31" version="1">MTSFDPDKWLSMLLECQHLPEADMKVLCERVRSILLEESNIQPVTSPVTICGDIHGQFWDLLELLRKGGMVPETSYIFMGDFVDRGHYSLETVSLLLVLKAKYPDKVTLLRGNHESRQITQVYGFYDECQQKYGSAQVWKACCSVFDYLNLAAIIDGETLCVHGGLSPDIRTLDQIRVLSRAQEIPHEGAFCDLMWSDPDDIENWAVSPRGAGWLFGGSVTREFNHVNSLQLIARAHQLVQEGYKYMFDEQLVTVWSAPNYCYRCGNMASILTIRDDGDRSFTVYDAAPENERDKGMQKTRKIGNMPYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP85</accession>
    <name>A0A4Q9PP85_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_950309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP85"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="301" mass="33291" checksum="B9BCBD67096F257A" modified="2019-07-31" version="1">MFTPQKSSRLLSAFDPVAGRWTALPLRQHTTSIRRPSPRPAHSRTVREQLSITSCNIHAVPFKRVERSQLILDRILGHKSSDIIFLQEVASDVRQSVLDDPQSALALPDDDWVAHLPTDDTAFQGVPFATMTLLSSERFVSPLLAEKKDVSDGKGEREGEGKGMLHNAFRMTLPSRYERDALCVTFDDPATPGHVLRLLNVHLDSLDSSFRRASEVHLLDRLLREGGCSGGIIAGDFSAIDPTMIRSYTGGRRGLHGAPRRLDKVVMLGLEPVDIEVLQPGRLDAGTPWSDHCGLRCTFTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPQ2</accession>
    <name>A0A4Q9PPQ2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_855505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145156">
        <property type="protein sequence ID" value="TBU56175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPQ2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPQ2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="37109" checksum="16A7CC91DC286CA5" modified="2019-07-31" version="1">MTSVNAGHIFEAAHRDALRFPHTGQVNLKDISEADARVLMSEEHKALGYRPPPGSLAAAAQAAVARHETQHAGEHTLTIDQEKLRQAALADAQRIKEARGDASGPASVDLNSIGDAEARKLMSEEHKALGYRPPPGSLASEAQSAAARHPDASSGIDTATLARAAFEDASRIVPKNPADLNVEGVGEVEARALMSEEHRALGYRPPHGSLAATAQSAAAKHPESSSGADPATLAQAAVQDAKKIEAERNGSPTNGTPELNLDTISAPEARALQSEEHKELGYRPPAGSAAAQAQSAVDSRADVPVTKEMAAQIQSEEHKVRGHLPESGTIASITQSMADKNVQDGGERKLGDVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ48</accession>
    <name>A0A4Q9PQ48_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_823700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ48"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="742" mass="82889" checksum="735BC27F7B087F07" modified="2019-07-31" version="1">MDFQDTKEKVDVESLEVTDEDVDSVVIKKDEDVAVEVISTEDDPTLPIFTLRTVFLGIGLSAFTSVLATIYTFKPQVSICPNASVSQLFCLIIAYVLGTAMHSTFLPQRMLPTAGSWRYLNPGPFNIKEHTAIVIMASTASNVAVAMEVIAALDLFYDIKLHPALAIFQIFASQMIGYGIAGLLRTLLVYPTYAFYPTYISVVNLLQSLHFGGALNHKKRRYFWIVFAAIFFWEWCVLVNDYPFPLLTAISIICLADNGRHTFVRNLFGAGSSNEGIGLFSFSTSWTLITQGNPLVWPLRTPVVVGMALGYIVLTACYYNNVFNGRDILWMSQSLFNDKGGRYNQTAILTPQNTLNATALESVGLPRYTTSYVISQMCYNFSLGAAIVHVLLWNWPELTKAFGKMRFLKSSQDIDDPHYQRKKYKEVPQWWYLLLFVAALALGIGCSYNKGDWLLPAWSVILFTVISSCIAVCIGFVAATTGFTLQIKHIMHILSAFVHPGRPVAVMYVNLYGNSTAYQCLYMLQDLKLGQYTKLPPRATFAAQMAGSIIGSIFNYTMMHSIVTNNRAALIDPVGTRVWSGWIIQSYNSSSVAMGALGKELFTYGKPYYLIGMAFFIGLSFPIPFWIAHKLAKKGSWISRAAEFINTPIIALYIGYLPYSVNGQWWSCLVIGLLSQWWARTRRPKWFKKYNYLTSAALDGGSQVILFILSFAVFGASGNSVPFPTWWGNPANLSVDRCALTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQB9</accession>
    <name>A0A4Q9PQB9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isoprenoid synthase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_931138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the trichodiene synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQB9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016838">
        <property type="term" value="F:carbon-oxygen lyase activity, acting on phosphates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024652">
        <property type="entry name" value="Trichodiene_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06330">
        <property type="entry name" value="TRI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01021">
        <property type="entry name" value="Trichodiene_Synthase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="318" mass="36373" checksum="E715D787E84C2CCD" modified="2019-07-31" version="1">MLAVMSPISSNLATVDEIVPDPHVEIKTLIRGFLDASNYQSPRSPHDAELRRKLAEELTSWPADIKPALIAKIMDGSCVYAETTYGHTTHEHRYFIALYTACLMYVDDLGERDLDAVMRFTGRFARGEKQPDKILQRLAELLGSAHDLWTQFGADAIISGTLDAVTAMYIEFTTKDMVAKPSATRFPYYLRTRAGLGPPYIHFIFMKEWRATPESYLQVLPDMEHWTLGTNDILSFYKEELAGETNNYVHLRASAERTSTEEVLRRLVEEVLDSARRMDALTYEDSKLTALWRTYMQGYLEFSLSAKRYRLAELGYQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQW5</accession>
    <name>A0A4Q9PQW5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1022805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQW5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="16564" checksum="110F9D1537E9FCD9" modified="2019-07-31" version="1">MYRTHARAEISGCTTPGAWLPPADGKVWRDIWILTDCVLITCAEISGDQSKSRGPGIPVQRAKDPDSPDTYVQGPSARSNPNTRLGLVSSRMECGTRLLCDGHLADRCRRRASEATILRVWTRMDGRRAVGVRGGKMGHHEESRLGICHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQY2</accession>
    <name>A0A4Q9PQY2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_1040281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQY2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQY2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="6">
        <location>
            <begin position="24"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU56779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="528" mass="57808" checksum="150211DAFEE0DC25" modified="2019-07-31" version="1">MDSSSADSESELSTEYYSIFTANYCSNAAAVVFIYEYLITIADEAQYFWKGKPTGATVLFFLNRYVSLCCHRDLVRSVQTGFAQIKLPYLDVRGRAAAGWMTAILVQRFLLHLQSAEREALDITSSQNGSRSSSIVFDQVIGSLGLSLAPESFLGESVEEVYEEGQLNGEDAKSEASRMGVSLTTLYERDAGFNARAHLGGSLDLGWESGQCALRENGLQEEFDKNSRPEGEEMRIYDGAGKLHLSHGEGGPSGPEGDQDFTPPQGPEDIRPEIDRTVLRKILLDAIPPHLIKWDHPLTSVRPLGNGQHELTFANGFTTVSDFLVGADGANSRVRPLLSPATPIYTGVNGVEISLAPETTKLPELQETVANIGKGMMMALQDSRMLGSQVNGDGRIRTYVYLRESADWSVPSDPAEAKAWMLNLIDYADESAIYPRTLYILPPVLRGGREPRGLELGLVLAELAKEGKLADLEAVDKAVAAFEEKMCALAGRVADKAERNLHAFIHPHAPQSTIRQLQQLRTEGPREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSW4</accession>
    <name>A0A4Q9PSW4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_959594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSW4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF8">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27222" checksum="DAFA370A935FE42E" modified="2019-07-31" version="1">MRLIITGVTGVAGLAIYRAALNDPAVERVTLLTRRAVPTWAELPANATEKTDVIVHTDFKTYAPELAQRLAEHDALVWALGKSSVGMSEEAYTELTYAYTIEAAKALKAAGAGSPERPFRFVFISGELADPEGKSRQMWARVKGRVERELPELFEGTNIKPHVFRPAYFFPSKDYPQDRLHQRSAIERLIDKVQTPLISTLLPAYYTPNHELARFAVELAKGRWPDHVLQGVAAAWRPKCQRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT37</accession>
    <name>A0A4Q9PT37_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT37"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="318" mass="34705" checksum="95251103A8C71C92" modified="2019-07-31" version="1">MAGNSEIQAAFDAFFANCWGYTSSALLAYDYILTFKSEVTLFWAGGRLSGATILFLLNRYITLAVQIFNASPFPSAFSVFVAWSVLSALQYLPWAAFSALRSYALCPNPYRWPVSATIFALSSVPIVTDMWVNLYRLSIVDDPQQGIIYTNSISASTGLKRDTTVEVLTRSSLIASDLAVLCVTWIRTFETAKLSLRSLGKKTFASILLLDGGLVLLMLSVLHMVFTLTGVAEDATSLLTSVIAVIEEPLTAILTTRFLIDLQKAQRKLAGSSRSVSLGELAFQAQTSKNTSRFIGSLGAQLPFRQDVDGEDEVQDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PT84</accession>
    <name>A0A4Q9PT84_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_821101</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PT84"/>
    <dbReference type="STRING" id="114155.A0A4Q9PT84"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12226">
        <property type="entry name" value="RRM_NOL8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034138">
        <property type="entry name" value="NOP8_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48029:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="158"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="231"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="174"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="59034" checksum="3D64922584492451" modified="2019-07-31" version="1">MDKLITKRIHISGLTPAITAKDLSDRLASFGTVKAIDGFGALDALGQPRKFAYATLETTKGKLARCMNLLSGVTWKGAKLRLGEAKPDYRERIAQEQAELKRAAEEADGEPPNKRRCLRGVQGVHARDMSLVTPENVATRGGWRVTPTGRLIRPMRMRPLHPLPEPTVAARPSAESKDRGKGKVDKVKIKKRVRDPPTRARRKTIDPTKYGSQHLKGIFLENAAAFIPPAPPRASVASTSRADVSERMTDSSSETEGEDVPEDVASSDDSEENEVPSVPAPQVPVSHAVTPSQAKVQVVPSIPIAQSPAAGHDLVEENKQSLNLLQSLFGDADHWGGAESLDSDIEVEDERSGPAPTTKELDPISVPVTDSDTAMEVEETSEESIAPAAKVVPQQAGAAQKTKLKDLFAPREEEAGFSLLDHLDLDLELEDDLPFDVPAPAPSAAPVQPLAAIQPPANHVFHTTTLDTSRPFFFPVDHGGGKRNVHDPTNWRTWFYRTDTPEAIRARWEEAKGELTAGWKRRHREAIKSRRRRGGGNGGDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU16</accession>
    <name>A0A4Q9PU16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_820551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU16"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26779" checksum="105B1AA161CB9DF2" modified="2019-07-31" version="1" fragment="single">MSATIGDPHPLPSASSTPHSPMLPWEVIERAIDHCSGDKTTLCAFALTCSQLHPRSLFVLFTDVHLRSTEQLTAFYHAVRAQPRLQPVVQSLSFPWNDFSPFPLLSILPGLRHVAFDTISSVNTDGRQISQLAQIGGRPFAASLRSLTIRGTSFPMQTAFLNFISAFPNIENLTCEHLDFHMHGDTPTRQELYPTHRVLLTALGGPVLNVRKTISWSDEFSRLFRPLGEKWALTEDVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUE3</accession>
    <name>A0A4Q9PUE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_948925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUE3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="70" mass="7462" checksum="5D0ED5C8152E6800" modified="2019-07-31" version="1">MWLMKGGPNVRANALCAVRPSNTRAHGLKIGLTGQDAVAGGHMATWYCPPVREIPSACRGAGWTTSARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUH5</accession>
    <name>A0A4Q9PUH5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_851828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUH5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PUH5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF34">
        <property type="entry name" value="NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="79"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="270"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="421"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU58171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="573" mass="63583" checksum="C52A0264A294DFE0" modified="2019-07-31" version="1">MATATNRVLRVALRGDNILTHPRFNKGTGFTASERKAFGLSGRLPHRINTLEEQYKRAYEQLRIDEEPLRKNTFLQSLKDQNWVLYYGLLSRHLKELIPIIYTPTQGDAIANYSHLFRRSEGMYLTFPELDSMEEDFLEQTKDRDLQLFVVTDSEAILGIGDQGVGGIGIATAKSAIYTLLGGIDPSKTQAVVLDVGTDNEKLLNDPLYVGWPNRRIRGKAYDRFVDKFVQLVRKHYPHSLLHFEDFGVNNAQRLLDFYRDKHAVFNDDVQGTGAVTLAALMAAVGVTKSKLAEQRIVVYGAGTAGLGITKQLRDGMGTIDNLSAADANKRFYLLDRYGLVKESLGPEKIRPALHEFVRPDAEWADVPTNDKGEIGLLEVVKKVRPTVLIGCSTSAGAFTEEIIKEMAKGTDRPIIFPLSNPTRLVEVTPEQANTWTNGKALMASGSPFPPCKMPNGKMYEIAECNNALIYPGLGFGAMITQARKLSDTMIIAGAQKLASLSPAHKDPDNALLPDFAHAREVNTEVAVAVAEQAIAEGEAGVDWDKEEVRDRIAERQWIAEYPHLVFDPKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUN3</accession>
    <name>A0A4Q9PUN3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_927810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUN3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020615007" description="Secreted protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11931" checksum="6FC53517C492E5A5" modified="2019-07-31" version="1">MLSGPLASVLLAVLCDIEQPMAVHVSRTHRPSPVLMTLNRHNTHDAMAWTRLSEARYRSGLDSEAGTKEVHLPSFHPLRNHATVFNKLVPQSLPCLAPFFLVRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUN5</accession>
    <name>A0A4Q9PUN5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_959135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <end position="84"/>
        </location>
    </feature>
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        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="153" mass="16708" checksum="3F7D60E0494E4616" modified="2019-07-31" version="1">MAKNPAEPVEQPEYNEEEGEESDDYEDIEDEEEASGEEDEGEEGVEAEGAQPRSNLTALLIGGEAGADADEEEEDEDDDFEDAPEQTLQSEASSVAGTKRSREEDEDVDKISGDYGEFQEAEEGVAKRARHAADNAAAEEEAEADEDEDEEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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            <end position="140"/>
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            <end position="181"/>
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    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="332" mass="36461" checksum="0F53A21606087457" modified="2019-07-31" version="1">MPMLIDVAELAGLAAEGALYGIFLCLFCVCGYDLVRRRARQESELSWPMVTAGVLLIVLATARFIVDVANVFVAFIRHDPRSARLAYLEDVTQPLFTTKHILFITSLFVGDSFVSGERISGLFSYLWVYPDIVAGYYTMWAYSNLPDQTIPSEAKWLKSFFSLSLVANALATSLLAFRIWYVDRQRAHVAIDSAGSSLTPIIRIILESGAINAATLFAFVMTLSFGSQGLEIMSEMATPLVGIIFSIVILRIGYRRHGDSYYTTQHPRSRTLTWRAGKSGTGVRGFTGAAATMATVADLSNREIYVNESTTSKLDGGDGHELTSFRVTASAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVE3</accession>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="4 5">CBS 464.89</strain>
        </source>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
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    </evidence>
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    <sequence length="108" mass="11738" checksum="ECA9B37BF1B5B062" modified="2019-07-31" version="1">MLLTLTCVSVPAEMTIIFDSGIRTGSDVFKAIALGAHVVMIGRLFVWSMSHEGVHGCRHVIKSLLADLDILMTVAGYRSITEDVYKNKEALRYSPSGVPPGPAEHARL</sequence>
</entry>
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                <person name="Ng V."/>
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                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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    </dbReference>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="316" mass="34705" checksum="4C07D5A29C4F2F31" modified="2019-07-31" version="1">MANKDLLKILEAHGQQFLQSFDTPVTIGKRKDGPTTTEDRSTRKKNRQEDESEEEWAGIGQGSSSGEEEDSDDEGFDEDDPSGGEGESDDGDDEFTYESGSRQPDIVVFSEASTSSMIPKKSKSGFMSSKVTKLTEEARRPANKKSSEDDEDDDLSNAQNDALLHRLVHTQLLSGSLNPDLNLTPAQRKKALAGRVMEAAGKAKLGKGEAAVRQKEHNRAAKHVRDGLTEKKKERQQKELEEAKQLGNYHPALKALYDASSTSHLRKKKRDRGMKMGVGSFKGGILKLSKSEISAVEGRSRGESRGTGSRRRGGKR</sequence>
</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="224"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="281" mass="29839" checksum="56807F4B4E4CD18F" modified="2019-07-31" version="1">MSSARSVSDATASPFNSSIPPSNAIAKPLSPEGITSTDLYLKHFAYAKLGDFATEEFSAAAQRHSALFANQRYNLNMWSTLSREALLTLRRDSQVSSSAEASKRLHSPCLTIPRSHAAAASGTQTLHLPPGPRHAPPPRLSLQDRAVLPAPHPLCSVLPLTPPTPANVAIEMAKRAEESMCGSAPYDIGIGIYVKIPQVHGPSSSSSESPLPPPSQNNYTPRASHPSLPQLSPNSSPAKVDDSEAINSDLDDSDPDNAQEGIEGGTVDWSSHPCPGSMFHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWX0</accession>
    <name>A0A4Q9PWX0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="10" type="ORF">BD310DRAFT_925440</name>
        <name evidence="9" type="ORF">BD311DRAFT_751649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143397">
        <property type="protein sequence ID" value="TBU31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145116">
        <property type="protein sequence ID" value="TBU59187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWX0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWX0"/>
    <dbReference type="OMA" id="VWFSHNG"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU59187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="37310" checksum="C1AF1D4E9F282EA8" modified="2019-07-31" version="1">MRPILLQGHERSLTQIKFNREGDLLFSCSKDSVINVWYTHNGERLGTYDGHNGAVWTIDVDSQSRFLISGSADNTMKLWSVQSGKCLYSWEFPTAVKRVAFSEDDDQVVCITEQRMGHQGAVRIFNINRDGDGTTQDEEPVSMFNPIGSKAVVCTFAHRPDIIITGHESGKVALFDAKTGDEIKTNEHAHRDTVTDLQLSPDRSYFITSSKDKTARLHETRTLTVLKTYVTETPLNSAALAPLKPYVLLGGGQDAMSVTTTSLRQGKFETRFWHKVLEEEVGRVKGHFGPVNTIAVSPKGDCYASGGEDGFVRVHHFEESYFRAKPYGDLEIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PX61</accession>
    <name>A0A4Q9PX61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_976690</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PX61"/>
    <dbReference type="STRING" id="114155.A0A4Q9PX61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051654">
        <property type="entry name" value="Meroterpenoid_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35897:SF1">
        <property type="entry name" value="METHYLTRANSFERASE AUSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30124" checksum="258DB716134A7FC3" modified="2019-07-31" version="1">MMIDDELRKRILDIQKRAYEEYPYPCVRAFHFVNLMMAANPIYSAVLEAGKTDRTLFLDLGCHMGTDLRKLVYDGYPASNVVGCDLRQEYFDFGYELFGDRDRCPIRFFAGNIFDLPDVAAHTAVVQETHPPSLASVNNLSQLRGNLTHIYTGALFHLFNEETQYQLAIRLALLLKRTPGAIVFGRHHGLEHAGKVDDHLGRDRYAHSETSWPALWKKVFIEVEGEAFVDKIVVWAKLTDGFTPNVFGAKKQHRMLYWSVQIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY79</accession>
    <name>A0A4Q9PY79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_924579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY79"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="169" mass="18335" checksum="3B4CE76349D54ECB" modified="2019-07-31" version="1">MSVPVCTIRRSAPTIFSWRLVAFQAVFDRVPSCTQLAQLVIFVDMRLPSPFSACSDGIRRSSCVLLPLPLQSTSLPSLKVFFSRPLVPAARVLEVVQESVSSGAQRDFWGRVWEKAQTDEPRQLLVVAWERMMENFFGKEDKSGGGGGKAGGVGTGSGGGRQDGKDGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q018</accession>
    <name>A0A4Q9Q018_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_815612</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q018"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020701249" evidence="8">
        <location>
            <begin position="21"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU60299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="494" mass="52100" checksum="3EBBB8E0CD088482" modified="2019-07-31" version="1">MLLGIFLVAMDGTIVTSTYASIGSQFEQLQSTSWIATGYMLSLTSFQPLYGKLSDIFGRKSCLLFAYIIFALGCLFCGLARNMTELVAARALAGIGGGGMQTVGTIIMSDISTLRQRGTLQGIANVAWAAGQATGAPLGGFLADSIGWRWAFLLQVPMTALAILSVSIFLRLPRSPTGDLRAKFARIDFAGAFTLVGSIFLLLFGLDRGGNISWSGKITVASLASSATFFLLFVVVELRWAREPCAPKRIVTNGSLIASYLANLFSNAAAFTLIFSVSLYLQAVQGASAGEVGLVLLPTIFGGVAGSLGTGLIMQTTGRYYVLTISAFALMFAGNVVVGLVTGPLKYTLAGLSIGASLPCIVANNIGIGAGVTSTLVALIANVGPADQAVATAVSYLFRSLGSVVGLSVGTTLTNDVVRKSLRRRLLGEGHDVEEIIKRVRESLGYLDQLEPAVRAKVVHSYRDGLQAAFWYTATLCAVTTVTAFFVKEKPLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0B4</accession>
    <name>A0A4Q9Q0B4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha/Beta hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_847915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0B4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="32"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="388" mass="42519" checksum="690A313DDFAD2C7D" modified="2019-07-31" version="1">MASPPEDQKNPAALSILQDSGPPEGSTDYTTVVLLHGFAWHSGIFAKLVPLAHAHNARVVLVNRRDYPGATPFSPEERSLLSAIATESASSPESDAAAADAHAQLEPFMRSRAREVSDLLARLVHDANIPKSQREANKGGLVLVGWSFGTVWMTAFLAHAPALHAGEGEGEVDLTQYLRRVVLLDPPYHVLGFPPPPDPYNPLFDSSIAPADRARAFAHWVSGYFVHHTDALDSTSASPSERERPAAAALERRAYLPSPPPTLSTLTPDEVARALYPSPGAPGGSDALLLAGGMRSGTFATLRDEALAVPADEGLRAVEVRHVWCDRSVWETTWTSWNLRWMFEEARQKSERLREVTWVKLQGANHFVHWDEPERILVALLTDSVEKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0E2</accession>
    <name>A0A4Q9Q0E2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_922301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0E2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="12661" checksum="7A392725441E462C" modified="2019-07-31" version="1">MRCASARTSSTRATFVARSRLQRPCGSPPAALTVSAEWRAGTGPGRTPADTARPTRGTDARVVYPLRRIGTLNAIRAGGPGETDLIRPIPRRYTIHATSLTSMATGWGCRRSATSRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0K7</accession>
    <name>A0A4Q9Q0K7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_947237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0K7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="464" mass="50544" checksum="4819006EB7269725" modified="2019-07-31" version="1">MESAEMTYVEPWHRSSLASDSMHGKDKVLITAMRGIKDWTWTVEMRRRYREGSIRRVTDAGAVDTARGLPGLSSSTCQILKHNVWAVEAYIHVSLQSDVYLRSLSDSLAMCGKSSVGRILPGVHLAILGMIVLRGTEDVLLQLPATGIVRPAVACRQGHGPRELVALPAFDRLAVDCPLISPARRVLLELLSWSSARTFPPHAAFSRAGIVCIGPLERAMVASIGTENWSSWAKPMHLIAAAVLEWRTRAEKCNAELDADWSLRFPYEDSQIESREPQREDVSGAVSGTLVHGSDAASLGTYGIASSTVDEFEVGVHPREVRLPRGGSWQFRKRSDRDIAPEDDSFRFKHAAQHSIGHEAIVGGRNILAFWRPAGSQRSSLPIIAAGSQGWDSSGGNHTANTAESLVERPGAGCRYPAHLPRRTNATDEFSLSVACSTSSMGETGAVQHRYATRCAPEDTTAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0V0</accession>
    <name>A0A4Q9Q0V0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA polymerase phi-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_947174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0V0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0V0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="678"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="764"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1165"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="764"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="786"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1205"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1217" mass="134662" checksum="B93DA21A3C1D7D4E" modified="2019-07-31" version="1">MSTTLDLFWHLPSASKKERIDASVKLISALEHFQSTFVPRDSPESSEDEDEARDTKKSDGLDALNAQDVSYSLRRLIRGLASPRESSRLGFAVALTELLSRIDTVTCSQILQLVLDSSKTQGSMTGQEERDVLFARLFGLTSVIRSGLLLRDTTLPSSSTVASDLASFKEVLVQLLALGEKKSWLRESAWWSIGLAVDALSASEVSWKNDAVDATIAAIYSEHKIWTPEKLALTLKLQSYHPSRDWKRVLSPTFKNPDLLSTENLAAVARILKESDADEDKESDLPKSGSWKPQLHFVWDTLLDQVLPQPPNAKGTVERSPKGSFPEFFRIVVDESLFASTSSPERKYWGFQVFQKALPRVSADDMPMLFTKNFMRSWINHLSNSDRYLHKAARQVATDLQNVVKGNPTIGFSLILQLTGVHGSRQFDRLTKTKTVESILTSMDEAGIQSYIDYLLKQVHDEPSASADAETDIQAVNTRRAWVIDQLAALVRNGAIPKSDAWIQTILDWLAVHGLFIIAKKSEKSAISALRSVPSPAFSEELRGNCRERLLACLADLTVQTTLIKEDTKSSKVAAVASDGRFWVSRVLSTIAELEKDVKHVKPLSEVDEEEAEQRQKAREVLARLKDAPEDRREAARGVELLLSATLLHAYCAEVDDADTEVLENCIDGASRMFPVEAKKGKKGRKSAAAAGEDKGKEKEQPEPVDVLVDTVIGFLEKGTAYVRAVANQVFALLAGSVQASTIDLILTQLERRDPDQLMADEDANMDDEEDGDDDEEAGSSSSSSPEEDEEDEENVDEEADMELRRKIEEALRVNGISAASEDSESESEEELMDDDQMLAIDEQIAAAFKARAAEKRQGKDVDAQREATHFKNRVLDLIDIFVKKQPTSPLIVRLIFPLVELVVSTGPDEKQLSDKATGILRNRIGKSKEVPHGVSKEDATKTLEELHNLARKASTPDVLATLNQCSLYLSKVLLHADDIEPVLTAYRESLHDFVARKASKLSTAFFDDFVRRHPQAAWKMRDDLVKASGDALNGYRQAQVFRLVQTLVNQLQALGDTKSEVLAFMPSLRKGILDTVSKACSDESTSLQPAHVKDILKLALGAVRQTKRFTQSSDELSTIWRPSKWTELSNTLASNDHFKASVGLQAMCKQLVQLLQESGTAVSKAKAADKDKTNSKEKVAVVSKRKAADRDGDEDEGVADGGKKARHKKARKAKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1I0</accession>
    <name>A0A4Q9Q1I0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Oxidized purine nucleoside triphosphate hydrolase</fullName>
            <ecNumber evidence="13">3.6.1.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">2-hydroxy-dATP diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">7,8-dihydro-8-oxoguanine triphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">8-oxo-dGTPase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Methylated purine nucleoside triphosphate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Nucleoside diphosphate-linked moiety X motif 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">BD310DRAFT_233399</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool. Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP. Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP. Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A. Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA. Through this antimutagenic activity protects cells from oxidative stress.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71395"/>
            <dbReference type="ChEBI" id="CHEBI:172878"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67393"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63212"/>
            <dbReference type="ChEBI" id="CHEBI:77897"/>
            <dbReference type="EC" id="3.6.1.56"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:31584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:65396"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71361"/>
            <dbReference type="ChEBI" id="CHEBI:172871"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:65397"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31575"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:63224"/>
            <dbReference type="ChEBI" id="CHEBI:77896"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31576"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>N(6)-methyl-ATP + H2O = N(6)-methyl-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67608"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
            <dbReference type="ChEBI" id="CHEBI:172873"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:67609"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>N(6)-methyl-dATP + H2O = N(6)-methyl-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169976"/>
            <dbReference type="ChEBI" id="CHEBI:172872"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:67605"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>O(6)-methyl-dGTP + H2O = O(6)-methyl-dGMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67600"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:169974"/>
            <dbReference type="ChEBI" id="CHEBI:169975"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="21">
            <dbReference type="Rhea" id="RHEA:67601"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.56" evidence="13"/>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1I0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1I0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008413">
        <property type="term" value="F:8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008828">
        <property type="term" value="F:dATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042262">
        <property type="term" value="P:DNA protection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03427">
        <property type="entry name" value="NUDIX_MTH1_Nudt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003563">
        <property type="entry name" value="8ODP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758">
        <property type="entry name" value="7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43758:SF2">
        <property type="entry name" value="OXIDIZED PURINE NUCLEOSIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01403">
        <property type="entry name" value="8OXTPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 25" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="24">
        <location>
            <begin position="30"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00026103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00030682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00053094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="TBU61037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23094" checksum="088B94A46B0CD61C" modified="2019-07-31" version="1">MALPPGLSYYDGPLVETANGGVSDWVEYKNVKAYTNAFVIVDDTKVLLGLKKRGFGRGLWNGFGGKVDLGETPLQAAVRELEEEAGITAPLEQCGTLFFAVDGVEAAFNIDVFRAHEYTGTITESDEMRPQWFSIQGDLLPPSKPSATLDRAPQEGIAALPPIPLEQMWADDEFWLPLMFARRYFVGRADFSADNKMLKWWFGAAPLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q202</accession>
    <name>A0A4Q9Q202_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_975195</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q202"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q202"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="85"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="264"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="320"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="518"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="581"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="622"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU61237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1245" mass="134946" checksum="C9BCE9E36D7BC9F4" modified="2019-07-31" version="1">MAPKNKGKKGKKPDDDEFWEKAGTSIAGNNIEAPADAGEASDDDFKPKGKGKASGFSAFAALGLEEPPVDEDGEEDFGGLMSVLKASNKKGKKDKKKDKKGASDVKFEDGPPPGDGSDGEAAAAKGDISAPKAPMQMTAEELADEEWGPVKKDKKGKKGKKKGKSTQEDEEDEEKPAEAPAALAPAEASPSPAPPAEKDEDEENAGDGAPKILSKKEKEKLKKEREKAKKKAQAAAKKATEGGEEAAPAAPSEPAPASAAAAAEAEDEEDEGGAEGGAGGGDKKKKKKKKAKKDEEPTPAPAAAAGKKKGAAGISALKALMEEKKRLEEEARRREEEERRRIEEEERRAAEEEKRREEEKQRKKEKEKAKREIAKKEGRLLTKKQKEEQRAAELRKQALLASGVQIEGLQQGGGFVDKPKRVVYDNRKKKKGPASAAGSSVPGTRDTSPVREEKPATPEPVPAPATPATPEPSAEEPQKDEDVKDDWEASSDDEQKKADSVKDSWDASSDEEEEAPKAKPASTPASKAAATNGSATPTQDKAAALAKEEKAQKPKVPVPPTKAAGAPKPANGAASAKGDPDSEESSDEDSDEDSDEDSDEDSSDESSDEGGMTTAQRQAAQRKAEAAARRQKAHEEALAARSKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVDAIKTKTAVMNRDGSQEYKIPGLLIIDTPGHESFTNLRSRGSSLCNIAILVVDIMHGLEPQTLESLRLLRDRKTPFIVALNKIDRIYGWQPIPDNDFRSSLEKQPRTVQRQFEDMSKKIIVAFAEQGLNAVLYYENKNFARNVSIVPTSAVTGEGVPDMIMLLVNLTQQRMSDRLMYLSELECTVLEVKVIEGLGTTIDVVLSNGILHEGDKIVVCGLNGPIITQIRALLTPQPLRELRIKSQYVHHKEVKAALGVKIVAPDLEKAIAGSRLLVCGPDDDEEELMDEVMSDLTTLLNSIDKSGRGVCVQASTLGSLEALLDFLKSSKIPVSGINIGPVHKRDVMRAATMLEKAKELACILCFDVTVDRDAERLAEEMGIRLFKADIIYHLFDAFTAYNNEIMEAKRKDAAPQAVWPCRLKTIAVFAKRDPIILGVDILDGTLRVGTPICVVKVDPETQKKEIIDLGKITSLEINHKSYDIVKKSQAGGGVAVKIEHAVYQSAKMFGRHFDEKDELYSHITRQSIDVLKSSFKTDVTNEEWLLIKALKPRLNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q296</accession>
    <name>A0A4Q9Q296_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_220096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q296"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="56" mass="6140" checksum="085EDF472572B14D" modified="2019-07-31" version="1">MVRDTHDHEPKLNGQIAVAPCAIRVVRALHLQRDSGLACLFEHVSTHGCQSVLPIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2J7</accession>
    <name>A0A4Q9Q2J7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_921404</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
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</entry>
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                <person name="Riley R."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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            <strain evidence="1 2">CBS 464.89</strain>
        </source>
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        </source>
    </evidence>
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            <dbReference type="Proteomes" id="UP000292082"/>
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    </evidence>
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</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
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            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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            <dbReference type="EMBL" id="TBU62175.1"/>
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    </evidence>
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</entry>
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                <person name="Pangilinan J."/>
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                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
        </source>
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</entry>
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    <accession>A0A4Q9Q554</accession>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="537" mass="58997" checksum="09532E54E836B82A" modified="2019-07-31" version="1">MSTSTPPPIDTPGGDQRQPRTLILCFDGTSNQFDGENTNVVRLYSLLKKDDDLGQQLCYYQPGIGTYFNPGVVSPIFQWCAKILDEAFAWYLDEHVREGYTFLMQNYNPGDKICIFGFSRGAYTARALAGMLHKIGLLPKDNPEQLPFAYNLYKSTDADNVALAAGFKETFCRKVQIEFVGVWETVTSVGVIMSRSLPFTAANTTIKTFRQALSLDEHRVKFQPNLYHWGIPNDTGASARVKEKTSKRPNTSMKRQRSLGSFLRRWPSKQRKNLASASLPKVRQTVDLEAAAVTTTDTSGPSDLSASSGANGGTDVLEVWFAGCHSDVGGGAVSNSTKLSLSDVTLRWMVRELVLAQCGVQFDQAALKRANIPQSIFQGEGMVLPRGATLHASPRDGAIPLTERKTDPVEDVNVPGQVDPSNPDPSNDENPGQQAPSGPSEGDGGDPLGVDVDALQPLHDQLTADPAWWLLEIIPLPYTITDATGKTSTKWWIHLGRGRTLPDSPKFHITVKERMEDADLKYMPRAVWTAGTETYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5R2</accession>
    <name>A0A4Q9Q5R2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_845085</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5R2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5R2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="509"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU61944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="561" mass="62042" checksum="ABF9020A8ACAE7BD" modified="2019-07-31" version="1">MAPKIEYYCPCLAESPYPPPPHLASSSYSFHALHNLFFCEECDAVRCNRCVLVEVSGYYCPNCLFEVPSASVRAEKNRCARNCFLCPNCRNTLTVVPSDPPEDVDSRMSPIVSTTLGEPPFFLYCNHCRWDSAEVDITFEKPTGLAAQLQKFEDSAPESLEFERLKEHFEPFLRASSSSTALPSASSHHVHTNPITAAASSALARDIPGVGKYNPLSRSRIGRDKAAHRQEYPDYKSRVEVGHAAALSGEVDVELLRHLETVGEVASLEQRWSNSWVTPLRASDLKPLRIPLQSKKSKRCPSCRHILIKPEQKAQSTRFKIKLVAANYLPAIAVTLPHAQAALEMMKRSSAKSVSAAAAAEEQQTAGALIAGHSYSFHLAFTNPLYDPIQIRLAKAVVPAHMTEDAEAAERARRSTFQIQLPSAAFPVGAFAEAWEYDDEDEDMFLDEDGVELLDARGKKGKDGRGKSRSVGIVDKRANVTIVSGEVLIPKEARGDVKFNMLVSYTYRSDDPEPSEEVEVGTPSRSHGTNKAPEMKNFSFYTVVDLGSIMYREEPKLTADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5Z1</accession>
    <name>A0A4Q9Q5Z1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_904035</name>
        <name evidence="2" type="ORF">BD311DRAFT_736197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143391">
        <property type="protein sequence ID" value="TBU33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145092">
        <property type="protein sequence ID" value="TBU62857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5Z1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5Z1"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="105" mass="11438" checksum="FC4BF571622E2DA3" modified="2019-07-31" version="1">MGWFDSSSDQAAAYDQVVNAPHKAELSHELLAAAASYEASKAYENHVAENGQPDSHAKAKEIAASLAGAFIDRIVETKGLDFIDKERAKRQSSQQIDEVVTVDNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7W5</accession>
    <name>A0A4Q9Q7W5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-hydrolase/oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_870575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7W5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7W5"/>
    <dbReference type="OMA" id="ELAWYDH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06262">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050855">
        <property type="entry name" value="NDM-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951:SF4">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE MBLAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42951">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="327" mass="36183" checksum="CDE994D97B0AA44C" modified="2019-07-31" version="1">MCKGSVTANTVRHTRPASPPTRFKSKPTAFSARRLTPSTFLIVEVDDVYDEHPFIYAKLVSAANTILLLDTGCGGKSNDPEVGVTSLREFVETVPIDDNGGEPLNPGGRMHYVVVLSHCHYDHILGVEQFAHDSPVLVSGNDPLFLAPDKLPTHSLCDNLGIRTPVYRPSFRPHLDQILSNDEKPLGVTLLHTPGHVPDELGLWDEEEAMLYVGDTLYEWAPIIFPNEGSIVEWFKTIDDLTTFVETSGKSDKAKVNCGHKTAEGPALEVLQTTRAFMMDVIEGREEVKSRTTKRGEEHVEYVQAGGRYSLICPTRLVREAKYALSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8Q5</accession>
    <name>A0A4Q9Q8Q5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein ARV</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_870399</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Regulates also the sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Golgi apparatus membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ARV1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU62994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8Q5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q8Q5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097036">
        <property type="term" value="P:regulation of plasma membrane sterol distribution"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007290">
        <property type="entry name" value="Arv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467">
        <property type="entry name" value="ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14467:SF0">
        <property type="entry name" value="PROTEIN ARV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04161">
        <property type="entry name" value="Arv1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 10" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU62994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="36739" checksum="D462548677CD947F" modified="2019-07-31" version="1">MPICTSCAASTPHLYTIYNSAYNFRLEQCTSCQAFADPYVEHDNLTLLLDLILLKRDVYRHLLYNRGLGARRAGDKPFRKDASISGDHVQGQQHYQSARWWLIVKLGFALICVDAFIRWTHISSNQPGDSSQIVTWNQAALTGFLRILVGCLFETAAFHAGVMLACYVVLKLVPSPTPPAPVSGIREQFRFSHVPLTLLYSSLTKLFLLFCLSIWRPDTTAKHQPAGGDAHAPLGPLHPNATTFSHPLVLRALALLDEDKLDRAWVVRNVLGGMAAGFGLRVVLDCHPVFTTMIILAGWLVKTAVANLVSGWVGTGLGGDDKAAGEMWLAYSIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8Z5</accession>
    <name>A0A4Q9Q8Z5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LysM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_870606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8Z5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="41130" checksum="6507A6774CCB2AEC" modified="2019-07-31" version="1">MPSSKPSVALCLACSASLPPGRANTKIYYTSCCSRPICPNCLIANPRLARYNPCLRCLAGVNAVNSRSLSGTLAGDGNSTPSRANVDGSVRDEDVFVLGDEDGDESETDSDDEDGRSVKQRAEGSIASATPSEAPPPRTPDYSGSIASHPHSLKSQTGSTADSETAAQGDIQTERGQPPKYYLRPDDTLLGISLRLGVDSRILCRLNNLPPSTLRTTPHLLHTRSYLVLPPSARPPPPLSPTERALHEERRARLALERSETRFQAMTKETDRDVAKAYIAIAGLSDSADDIGDVKEYDKGDGRGLRKRRPHAGELHGEGDTGLEGRAMEQYFDDEDWVSRERAKGRKVAIPSFPVAGPSRVAEKMVAGEQKPWWRWRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBP4</accession>
    <name>A0A4Q9QBP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_954592</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="295" mass="32962" checksum="AB07DD05EB9227A8" modified="2019-07-31" version="1">MSCTRGYHVSRVFLTEYRLTFPTIRIVTRDPSSPPKSTKLAKLGGELHPFGEPLDTILAGADVVLNIIPPPLLSSEFKADILQATVRNGVKVYFSSEWGAYDYMNENVFPVYEADEWQQKRALQIEARKILSDKVKLINLNGGGFLTWWAGPNRILGWDADKNVFSTVGPSTAKISLTHQSDIGRAAAQVSVLALDPATAARVPTDIRIAGQSVSYEDLRDLVSRVKGLPKGDIVSQDLAALKEKIRKDPPENIWEYVLVLFGEGKLHCKETDNELVNPRETLWKWTLPEDEFRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCK2</accession>
    <name>A0A4Q9QCK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_397843</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCK2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="157" mass="18077" checksum="710364DA0424931E" modified="2019-07-31" version="1">MVRPTVLACMLAIAYLSNNMQVLQNRYRSFRLSHGWRWRGSTTLAGHLLACGQVLDTLSRNDRNERTDDRRFHCRAQKREIIRLVRGRPEGGGPEPEGIADHMFQRRPPTVPYPYRSCHANDTNAMQTSMRRRPPFDVRCTTRASGRLVNARTRGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QCT3</accession>
    <name>A0A4Q9QCT3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_1034649</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QCT3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QCT3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="161"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="273" mass="30718" checksum="4A54CB136E02B025" modified="2019-07-31" version="1">MRQKRAKAYRKLMSLYSISFGFRQPYQVLIDSHMSKEAVTHKIDLVKQLGAVLQGTVKPLITQCSVQELYDQEKEFKPAVELAKTFERRRCNHRQPIPGDECLSSVVGETNKHRYVLATQSQELRQKLRAIPAVPIVHFNRSVMILAPPSDATLRAKALKEEKALHPSEPETTKLTSATATPAEPPRKKKKGPKGPNPLSVKKKKQKPDANAPKSEKQPEDSKSQVGEKRRRDDGDGDEIATQQLEGVGHKRKRRRKHGQPATTQGEDVNSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEZ9</accession>
    <name>A0A4Q9QEZ9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_912047</name>
        <name evidence="5" type="ORF">BD311DRAFT_744857</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEZ9"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEZ9"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022626">
        <property type="term" value="C:cytosolic ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1230.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU35924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU65771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="86" mass="9335" checksum="79E927F5F8514D2F" modified="2019-07-31" version="1">MENDQGILVDLYVPRKCAATNRLITSKDHASVQISVVDVDADGRALPTSTTFALSGQVRADGESDDSLNRLATKAGLLRNVWSYQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K1Z4</accession>
    <name>A0A4V2K1Z4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_915764</name>
        <name evidence="2" type="ORF">BD311DRAFT_773737</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K1Z4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="52" mass="5961" checksum="1A644B5AB5ACC6C8" modified="2019-07-31" version="1">MEFGGRIDAGSKSYVRSTRIRPPTPQRPRGSPRTGCRRLSRGHIRIRERAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K694</accession>
    <name>A0A4V2K694_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_790541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145323">
        <property type="protein sequence ID" value="TBU51423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K694"/>
    <dbReference type="STRING" id="114155.A0A4V2K694"/>
    <dbReference type="OMA" id="RNIWETH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="326" mass="37198" checksum="BD94BB4FFBC26DD7" modified="2019-07-31" version="1" fragment="single">RTDLPAAHRSFVLYIEEYERLYYQRRRERLHFVRPSLHSLAHIVPEASRIGPGALHSQWTLENFIGNITREIKQHVTPYANVSERALRRCQVNALKAMIPSLAEPDDIFPQYAEILGDGYVLLPARDSIQRVIPSVEAAALRDFLRNEGVTLRDPDWSAPVRRWARLRLPNGQVARCAWKECALEARRRKPRRARMVKVSTTLRDNTFAEVQYFFRLKIHDHVETMAMLAYFTPPDPDIYEFSRGTLLACSHLGETSRAVIFVKQIVSVVAMVPLPMTSEEATTSDADTLYRDRFFVVEKPGLDVANIAGRVEDITADVDGLDIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K6Z8</accession>
    <name>A0A4V2K6Z8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_969962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K6Z8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="87" mass="9427" checksum="72DF7481A839424C" modified="2019-07-31" version="1">MAWSISSSATSILVCHFILNLRRVERSHMHQSEPGTLSDGLQFAMQSGTTLPHFVASFAQPVHVGSFETEVNMTSGSSMELESSKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7A3</accession>
    <name>A0A4V2K7A3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_826094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145171">
        <property type="protein sequence ID" value="TBU55278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7A3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="53" mass="5666" checksum="879FE98430B3CFF9" modified="2019-07-31" version="1" fragment="single">NISSCYVPCLSPSGTPLDTALTPPDFRTCLRLDTYILVSTLFPSPSRSPPGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7X1</accession>
    <name>A0A4V2K7X1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_928675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145133">
        <property type="protein sequence ID" value="TBU57768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7X1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="54" mass="5948" checksum="BCEA57D6DCAE1D3F" modified="2019-07-31" version="1">MLVQDEAAKTDHILFSPDREPSAHCTPPGIHPTPPLFCAPKRALARLQQSRTSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K807</accession>
    <name>A0A4V2K807_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_927833</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145128">
        <property type="protein sequence ID" value="TBU58168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K807"/>
    <dbReference type="STRING" id="114155.A0A4V2K807"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10001">
        <property type="entry name" value="HDAC_classII_APAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF17">
        <property type="entry name" value="HISTONE DEACETYLASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU58168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="360" mass="40085" checksum="D65E8DDE91115042" modified="2019-07-31" version="1">MRVYWHSDSLLHDPPHEILSGRLVTYLESPDRVKAIEGALEQSDAFEVIAAETDWPEDIKDCILAVHSKEYVEYLENIYSEWTAIGGDKSAVFPETFQHRSMQSFGSRNTNSMSPLAKPGVYCFDLSCPITSHTYRAAIASVRITLSAARYLATARNGSPHFGVFALARPPGHHTQDALCGGYCFLNNAAIAAKYLLEHHGSKCIAILDIDYHHGNGTQQIFYHNPQVLYVSLHADGDYPYFTGSSEERGSGPGLGYNHNLPLPRQRTTDDLYCDTLRKAADIIQDHAEVDYLVVSLGVDTYSEDPICDFLLTQACYPRVGEIVKSIEKPTLFVMEGGYHMETLGENVRGVLLGFEGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8G4</accession>
    <name>A0A4V2K8G4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_362405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8G4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17693" checksum="C7BCF62D53EF7F79" modified="2019-07-31" version="1">MQDFGLRRRRHGPMQGATHNRTVRAQRRSVAQPTRRTPFDPSALQSRTIRSVPVQNEENQGREGSLRLLLSTSTYQGTDSRTSQRRSEAGGRGRWKITVSGRNRVCAAGFVWHIRMQAAIAAAANSNSTYTEGLTVVRGEARRLSAIYTGLLDISKIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8L2</accession>
    <name>A0A4V2K8L2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Delta-sterol C-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_330965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8L2"/>
    <dbReference type="STRING" id="114155.A0A4V2K8L2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000232">
        <property type="entry name" value="Sterol 24-C-methyltransferase erg6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1 3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="4">
        <location>
            <begin position="83"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU60408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="382" mass="42983" checksum="5EB844F85026F5B3" modified="2019-07-31" version="1">MSLSSLLLFRPPPFPFLARSTGVSKANLNEMAPSATETTAHADGRVGRRIENYTQFWQKDISKEASHDTENRLENYVDVINGYYDGATGLYEYGWGTSFHFSRYYKGEGFYQALARHEHYLAFKMNLKPGMRVLDVGCGIGGPAREIAQFADVNIVGLNNNEFQVGRARMMTAKAGLSDRISYTVGDFMKLSEQFGENSFDAVYAIEATVHAPSWEGVYGEILKVLKPGGVFGVYEWCMTDKWNPSIPAHKEVAHGIEIGNGIPEMRPLAMARQAIVDVGFEIEHEEDLADRPDPIPWYYPLEGDIRKAQTLWDMFTVWRMSSSGKFVTHHGLWFIEKLGIVPKGTWEVGETLKIAADALVKSGREKLFTPMYLVVSRKPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9C5</accession>
    <name>A0A4V2K9C5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_629315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9C5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF6">
        <property type="entry name" value="GB|AAD46013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="517" mass="56728" checksum="B94BC90652CFEE2C" modified="2019-07-31" version="1">MSRPPCRPLRISSLANASVTLALQLRKFLLEGDSEDDVGPKDLLACLRHAASGGLRASVLGFLGRSGISLGFMLLGLRKVPETYRLDAVRHALFGESSVRTAAMLGSFVAIYRLVKNLAQSSSVKPSSKAGINEIDEEPPDINAYEQWIIPAAAGGLAAAIGISFEKRTSRPGIAQEALARGLQGWYNVTSSTKYGFNIPYGDILAYSLCMGQLMYVFLMRPEAIPNGLRKWFFESCGVPAEGVYINHDLVWNRTYDPKHMETIMRRKDITPENFTELAEHLASHDLPQSPAVPCAVMHPAMTSCLAYPPMFLWDRFKWMLPVYAAVHSATLLLMRPTLLVKYPVRTMLSATFAIGRTSIMQALNPTVYQALLCSKSNLYNALTVLRSSSGNSSLAVRLAKALPSSVVDALVSDKSFFVMGMVMGTPMIMEERRRRAMFLLCVLPRALESVGVLLRSAGRVPNTGRFGPTLAASVGMAMVMSVYQNQPQHLSSPVRRILHQLIGPIPGRKLLLPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9D0</accession>
    <name>A0A4V2K9D0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_808603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9D0"/>
    <dbReference type="OMA" id="TITWINP"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006078">
        <property type="term" value="P:(1-&gt;6)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042546">
        <property type="term" value="P:cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045328">
        <property type="entry name" value="Kre9/Knh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28154:SF1">
        <property type="entry name" value="CELL WALL SYNTHESIS PROTEIN KNH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020793151" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU63438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="22682" checksum="4DE051D92657D16F" modified="2019-07-31" version="1">MFSTALLVLAAAVSPALATIYVTSPTASSQWTAGQQQTISWQDDGQSPSLANFGPSKVSVYVGNQIQQTPVQVITQSVDVSTTSSIVFTPDASTGQNGQYYFIRFESLGLKDATNAAFPALAFSSKYTMSGMTGTFTAEELAQISAAVSSGAAATTSAAASSATPAGTTTTSATASKITTSKAVSGTSSAASSTASTSKSNGASTLPLSALTGVAGVAVAIFAAMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9I3</accession>
    <name>A0A4V2K9I3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_915207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K9I3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000630">
        <property type="entry name" value="Zinc finger protein 180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050589">
        <property type="entry name" value="Ikaros_C2H2-ZF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404:SF114">
        <property type="entry name" value="KLUMPFUSS, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24404">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="343"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="112"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="396"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU64028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="432" mass="48127" checksum="FD953166B23F2EFE" modified="2019-07-31" version="1">MSSRHNNLLPGSFGRLSTADLNQGVRHSPTRRETYSSSRDTRPPPSESPNSLPAQSQCVPPQSSSKEKQPNATRATQLPLSIYELPTATFMWARWKPDDDSQTRIFVRYRTHQSDTDSASTYSSSTYSRPHSPVSYISPRISPVSTPPPLPYSRKRSSSAESDDDSLPSPSDRFLKLPRIFHNNAPSRVDSARSATPRIPHEYATYSDNLGDKEAMEAYPSGSGAGSDSSDVELRPAAFFYPAHQSNSSRGEATFPRSMTPTADTPAPAYTALREESEESESDLKNEWIKYTFPSPETSAGPDFHCTWQEKQRDGTSKPCGYSSKKHLVKRHIESKHLQLRPCKCKFCGKGFSQKSNLDTHLNTHTNNAPHKCHYCDEHFKDPARRHRHMIQVHRHVSSRTKKGRLGTDVRAGSVAEASGPDVEDLTAPQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9R3</accession>
    <name>A0A4V2K9R3_9APHY</name>
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        <submittedName>
            <fullName evidence="6">ATG16-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_291450</name>
        <name evidence="5" type="ORF">BD311DRAFT_801753</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG16 family.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
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        <property type="project" value="InterPro"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <location>
            <begin position="11"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="223"/>
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    </feature>
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        <location>
            <begin position="257"/>
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        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
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        <source>
            <dbReference type="Pfam" id="PF08614"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU35069.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU64888.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="274" mass="30845" checksum="4E1F54AD38B5A82C" modified="2019-07-31" version="1">MAEPSWQETLRLRLVERNARETAYASIIEQYRRLAQQTKLLKERNASLLRAMGTARPNPSSSTVFVPGTGDDNPVRAAYIASLESQISSLRDELATVYKTQGQNAQRLLAMNETLREKEELSRLDSESLRKSRDEIAVLRKKVEQHNELMAEKDRTAQILHDEINTLQLELSQIEERNQILTKDNAKLLQRWLDAKQAEVNRMNQANEFYEDMHSRRQAVMNWQAGQKSEDGDAPAANTNGSGNGEEGKEPGATPTKDGTPSQAETDVNLTPNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K9T0</accession>
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        </submittedName>
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        </lineage>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="111" mass="12465" checksum="90B329A858B01C42" modified="2019-07-31" version="1">MEEDRADDSQLQEICTTRHCDAAHTATTKSRLLRQKSHRQSTNAPHPGPIVHNLSLLVLQPIMTVSRSSTHSSPANRRASHRRDAFEGWNGRISASRARWRTTSTRSSPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWW0</accession>
    <name>A0A4V6MWW0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_812944</name>
        <name evidence="1" type="ORF">BD311DRAFT_659581</name>
    </gene>
    <organism evidence="2 3">
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        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143408">
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWW0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU30075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7346" checksum="047FA5BB2CE921CF" modified="2019-07-31" version="1">MVESHGRSLLGDKLSRQLQINKGLRSEPSYPLHGGPAYVPSRSQLDSEAVVCLPPLRHMRQMPPGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MD58</accession>
    <name>A0A4Q9MD58_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_614333</name>
        <name evidence="4" type="ORF">BD311DRAFT_766719</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143482">
        <property type="protein sequence ID" value="TBU24318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MD58"/>
    <dbReference type="STRING" id="114155.A0A4Q9MD58"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU24318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU56475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="154" mass="17834" checksum="029053A639CB73A9" modified="2019-07-31" version="1">MVLPHYLCSHIQNAFRARLQHIAVHHTTQNLAILSILLRSGFLSNVTRGTVEAPSPDEFHEAPESHKRIWADLKYRDDRPVLSDMELISHPSKPIFMELSEIRRLCTGRRVQNVKPLRMGEIAIVKTKDRENEWLEAREALQLRLPGEVICRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MR82</accession>
    <name>A0A4Q9MR82_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_244913</name>
        <name evidence="3" type="ORF">BD311DRAFT_224006</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143406">
        <property type="protein sequence ID" value="TBU30350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145258">
        <property type="protein sequence ID" value="TBU52279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MR82"/>
    <dbReference type="STRING" id="114155.A0A4Q9MR82"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="219"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="608"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="644"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU30350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="729" mass="80207" checksum="56B8184853BDEBFA" modified="2019-07-31" version="1">MPVPPMDVFGIVYIIENAQQFWSELEEILHIPDDITLSKLDATLRSYISFCAAYHEQYLQSPLQLQHACDMVLASDLFSFHSERMCELMVEDAQTNTDPHYEMILYNVMLTYGRRTPSFLRSQKRWHPLLPLLMDHVRNDLDPEVDDGYYGVASTGGPSSGAARGVAVPIEAKLRSLAVRLLYEVCRVQKMSLQDLRIFDDNFIDYLFDLVEQTRGMQDETFNYSVIKFIVALNEQFMVASLHPQTPLPNGPSAGPGFAQQQAADPRGPESTNRVLRTLMSRAGSSPTFGENLIFMLNRADRTPEDLCMQLLVLKLLYLLFTTKGMAEFFYTNDLCVLVDVFLREINDIDEDNESLRHTYLRVLHPLLTKTQLRNMPYKRTQIVRTLEGLIENETIRDVDPTTKRLVMRCLSGDWCVQFRKTAVSAVQQQEGRKMSIYEEEVRRGESPGLDAVSAAAPRSAGPSIGPESVNPILGRMDSLRGKHAKASRSVEHLPLPSSSGSPPKHRSISGQYHHLHHHHHPSEQSSSHTRKGSITLSAVRQASGDSMTSLPRVAVATAHPSSAAAKHRVRAGSFNVEATTTSFSALSVQDPPHPHSRPRRILDSSIPFVDKPTMGSAPPQIRVVSPTSPTRSPSDRHHVVDLSPPSGSSGSSSTSSLVGSPASTPSTSPRRKAPPPPVKARRTPPAPPVRQGARGGVTGAVPGSPLSTIAASSHPNLPALSAGKASAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MT92</accession>
    <name>A0A4Q9MT92_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar amino acid transporter 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_957602</name>
        <name evidence="12" type="ORF">BD311DRAFT_754505</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MT92"/>
    <dbReference type="STRING" id="114155.A0A4Q9MT92"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="45"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU30537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU60557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="473" mass="51664" checksum="64E923DEBFAF9648" modified="2019-07-31" version="1">MVQYGATQGHRDPQNTVDDPRTSREDDALLGADATARRPKKDGHATLTSSTSNLANTIIGSGMLTFPLALASAGLIPGIITCAFSGAVGAFGLYLLSLCAAKAPHRRASFFTVAELTFPRAAVFFDAAIAIKCFGVSISYLIIIKSLMPNVVMALYHDLTSPDVNPPTWMLSGQNWITLIMIPLVPLTFLRKLDSLRHTSYIALFSVAYLVVIVIVCYFFPLEGTQKPGEIHLIKFTPGFVSTFPVQVFAYTCAQNLFPIYNEIQSNNQKRMNIVIGTSIGSAALIYEIIAVFGYLTFGSKVGPNIIAMYPTTSLFIAVGQLAIAILVMFSYPLQVHPCRNCLDKVFHAGHVPKPVTATEDDIIEDEHHPSHDMSDLKHSLLTIAIVASGFTIAYFVDDLKLVLSFVGSTGSTTISFILPGLFWWKLSRDDPSANKLLSKASLGLAIYGMFIFVFCLSFNIYGLFHPESENVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MVT6</accession>
    <name>A0A4Q9MVT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MICOS complex subunit MIC10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_928280</name>
        <name evidence="10" type="ORF">BD311DRAFT_754836</name>
    </gene>
    <organism evidence="10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Mitochondrion inner membrane</location>
            <topology evidence="2 9">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the MICOS complex subunit Mic10 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143406">
        <property type="protein sequence ID" value="TBU30416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MVT6"/>
    <dbReference type="STRING" id="114155.A0A4Q9MVT6"/>
    <dbReference type="OrthoDB" id="1916310at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007512">
        <property type="entry name" value="Mic10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21304:SF0">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04418">
        <property type="entry name" value="DUF543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU30416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU57923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="9514" checksum="54CD9AC7E02D6089" modified="2019-07-31" version="1">MSSTPKPTSSENIVAQKFDRCLADLIVKSGVGFSAGVIASVILFRRRAWPVALGTGFGAGAAYADCDRSFNPARIPGTRVIPATEAKKDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N0P5</accession>
    <name>A0A4Q9N0P5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_107166</name>
        <name evidence="2" type="ORF">BD311DRAFT_746973</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143389">
        <property type="protein sequence ID" value="TBU34010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145198">
        <property type="protein sequence ID" value="TBU54065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N0P5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6957" checksum="43893C87F6F57469" modified="2019-07-31" version="1">MNARRQCNGMLAANMRRKVRAISRDRNTSNELPTQICSYEGPSEETTMRHGHQHNAPLTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N201</accession>
    <name>A0A4Q9N201_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_930593</name>
        <name evidence="11" type="ORF">BD311DRAFT_794157</name>
    </gene>
    <organism evidence="11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N201"/>
    <dbReference type="STRING" id="114155.A0A4Q9N201"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="5"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU33917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="338" mass="37194" checksum="9A99DE11293080B8" modified="2019-07-31" version="1">MAGFLEFLFLAFTLTFSLVVSLGITVPLTGALVRLRANYNPRALQLDPEGNVNVHTGPIVTSFFGMLRRVYRIEGWAGLYKGLMPTASATIVMTGFAVAAMDSKQLARHGRVDPPDVGMLAALVYAAFGTLVSLPAAIITYRSIVTPYRLPWFRPIYSLRVLLTPTERRRPWVLYFTPGLVTAQVLQIAYSVVILYSLRRLLVPVGGDFSPARFGIYVAIEILSTAVICPLEVITTKLAIQRNHSAVEYNSVEQEVEDDAVEAPEYAEYSGQEEDVIGLRHEKDPYLGFADCVKRIIDEEGWQTLYRAWWVTAMAAVLTALAVGASALQTSGVVVGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDW9</accession>
    <name>A0A4Q9NDW9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_383902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDW9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="141" mass="16014" checksum="49AD4B456D834ADA" modified="2019-07-31" version="1">MLPDYPARLSLRTTLLIRPTSHSLLTPSRTRRHNLRIYTLLLCLPLRPCTCRLVCRGNSRCSHRLRRIPSAMCTHHRPCVGIVAPPKRRFDFLLLLLLFWLRHSGCRTAPRSVPTVVLQHDLFSAPSLEEDGCKLGGLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NGP5</accession>
    <name>A0A4Q9NGP5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_392321</name>
        <name evidence="3" type="ORF">BD311DRAFT_103799</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NGP5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU31736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="228" mass="25662" checksum="084D9E0E2657B0EF" modified="2019-07-31" version="1">MSALPSDTASDHLLNKPDDLSPTSEEHSPTVSLPPAPEPSERFMFLGKIIMPLSFLSAWGWYRYFTFIFAHIVFRWIARIYPRLDPSGHLVKTSFSTMSNIASLFIYAQVIGLYAVYIIPFAIRYRTCKEAKSFAPATELRRRWTPSFWTPAVRRPVSHVWAISLCVLSAYTVRALEGAKVPVLDPLRAAMVGAVGRAVFVVGRNSIYETYPNSRIADETGEYDVGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NHH2</accession>
    <name>A0A4Q9NHH2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_937993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145213">
        <property type="protein sequence ID" value="TBU53474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NHH2"/>
    <dbReference type="STRING" id="114155.A0A4Q9NHH2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF90">
        <property type="entry name" value="CNNM TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="653"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="868"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="446"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="666"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="883"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="900" mass="95625" checksum="93962413301F64FF" modified="2019-07-31" version="1">MVPPQPPATPASPFPRLLISLASAASRHVPFLRVHDPYRAEPSTLGGSGVHALVRRDIHDADHRVQFVLFSCLIPILVLLSGLFAGLTLGYMSLDETQLNVLSVSGTPKQKLYANKIKPIRKNGHLLLVTLLLANMIVNETLPVIADPVLGGGVQSVVVSTVLIVIFSEIIPQSLCTRYGLYFGAKMAGFVQVLIWTLGIAAWPVAKLLEFVLGPHHGIIYRRAELKELIAMHSNGGELGGDLKMDTVTIIGGALDLQEKVVRQAMTPIKDVFMLSIDAKLDYETLRRICRTGHSRIPVYEEVEIPVPRLVAQGHISEADLADATGSSRLSLDGRQTQTQKVKKIVGILLVKQCVLLDPNDATPVRKIPLNKVPFVPNNEPLLGILDKFQEGRSHMAIVSRFSVERATSVKKAVKRGLTQRLRSTVGIGDSDSGSSSDEDEAQSASHKKRPRKPKRHSSNDETLHDESSADAEPEGDEAHVRKGSHRRGRSRRPADIEMGVVDNGVPESKKHGLTLPKVGGWRGWEQSMPADAVLTKEGVDEFLQSVDPAVMPLGIITLEDVLEELIGEEIYDEFDPQGHPDLSSYAQAEANAAPSLKRTGSAPQLAASDSSAATAVVPGVSDGTLHVPVSTSGLIAKPKALPALRSLNFKVPGFQRSRSAPPTPRDADVPEKEKDGAREKTGVPDGTPLPPSVPEGVVAPQAVTISVSGDSAAMCTCDMTGTAEKPVTIPADEPNASRYAPPFAPVPVAATKAAAGASAVVSSADGVLGAANMGRARSVQGITPGPSIAVIPAPGLNLAFGPPSRSASPAPSLEQAILIERKRRAASSSGNQAGTKGGWFKSSPLNGGDARQGIIVAERVKRDLQPHFVAPTSEAADASAFEDVRKPNEKDTVGPDKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTG2</accession>
    <name>A0A4Q9NTG2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_609119</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTG2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="166" mass="18422" checksum="2734C085FD8B9032" modified="2019-07-31" version="1">MHPGSGGCPTVRPSCASDSDSSSPPTRDTDSWPRPCSLSFLPFASPLTVRSRGPPGRRDSDQHVHSKRFHNPAPPVRIVFLIALPINPAGSSAGSERWLLMHMHIRAALLSRSYRLTGECYCFACNRGTVCFSCSRSLEVCMTQSLHPTLLRFRQRRSGDKYDGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTM8</accession>
    <name>A0A4Q9NTM8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RED-like protein N-terminal region-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_938578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145221">
        <property type="protein sequence ID" value="TBU53208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTM8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NTM8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039896">
        <property type="entry name" value="Red-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012916">
        <property type="entry name" value="RED_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12765">
        <property type="entry name" value="RED PROTEIN IK FACTOR CYTOKINE IK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07808">
        <property type="entry name" value="RED_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="150"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="426"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="445"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU53208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="471" mass="50869" checksum="8CEF814DC3488288" modified="2019-07-31" version="1">MDQDSFRQLLQKPSAASPPSNTAAHVRGSLLATATAGKKKAKTVNAPQPAFKPRTLKKGAKGEAYRDRATERRLGTNNDYAQVEALAEDFERRAAENADRLAVEEQRKYLGGDSQHTVLVKGLDFALLEQNRARAAAEAAVTEDVFLEQAFEESSAQPKKRTREEILRDLKSKRGTTSASAAQPSVADKALEEAKKAGKFKPIGFKPVGSISTGDGKVKRKKKVKAGEVEENGERKKKRKVTTETSAGPAAAAPPVSATSIQEERSVAGPSAVPPSKPPPAGEPEPEPVDEDFDIFADAGEYTGVDLGDDDEASDDEGATRPSERKPQDEEDGEVHDSGPLRPGKWLATSDDEREPTSPPSPAREGTSTARSESPQRRPEVPLHPPSDEEDGEMEEERPIRLQPLSSSAIPSIKELLAASEEAEKAKKRKAKKDKKKAGGGEGVSGEKDIKAKVDRDYQRLKAYQEKKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTR3</accession>
    <name>A0A4Q9NTR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_819952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTR3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="276" mass="30592" checksum="E6E875577ADD9962" modified="2019-07-31" version="1">MLLLLQVRRSCPQPCLISTCADRLAIVPAATTGDATKQALLSVVQVWLDRLQAMAVIVNFIFVSIDSMVYSFPSRPPDFSTWSSVDLLVSASLGGAIILHVCASILAYIASFVLIRYRLSDAEEQEQSTERPYTASDGQHRTHPMRAQSFSAATTLAPALAPEWNEYIDLRSLISVHKVPLRQYILCGMVPRKRRVKNEIEALATPDDPVVRVTVLIRCHTAIAVMTQLGFMLALLGILAYFWTGLPRMLGIWATVLLEGCLFAMGAVMVQANWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUP7</accession>
    <name>A0A4Q9NUP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-serine dehydratase</fullName>
            <ecNumber evidence="11">4.3.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">D-serine deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BD310DRAFT_944967</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the conversion of D-serine to pyruvate and ammonia. May play a role in D-serine detoxification.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13977"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35247"/>
            <dbReference type="EC" id="4.3.1.18"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:13978"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DSD1 family.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.18" evidence="11"/>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUP7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NUP7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000016">
        <property type="entry name" value="D-serine dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0216">Detoxification</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="15">
        <location>
            <begin position="336"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00066349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="TBU63885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="462" mass="49894" checksum="800F4C650CDF5586" modified="2019-07-31" version="1">MGAEEHPQSNPLVPKQSRTPYHISGKPEKQDLVDEYKGQNLDVLRTPALVIDRAVFARNCAKMHQLAQNLGARFRAHVKSHKTPEGTRLQLLSTVDETHSIVVSTVMEVCEVFRAGLMADGTVKDVLYGLPMAPNKIADLSALTDELSAVGASMRILLDHPDQVKGIEDWEATKTNHREWSVFIKVDSGNQYCAPDKSPSRRAGLKPGTPAFTTLLEAALASPSISVYGFYTHAGNSYASTSFEEATNYLLSEVTAVNTAAAVALKLIAAKPHLSQPREPYVLSVGATPTAHAATEELRAKLEATLNGVLELHAGNYPLNDLQQLNTGLISPRDIASRVLATVISYYPGRGEDGSDEAMCDAGAIAMSKDTGPRPGYGDIIGKPWRMGRCSQEHGILAQMPPEQFALGPIQGDGSLKLGDMVQIVGQHACLILAGYPWYYVVDSGVGDGNTVVDVWVPWKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NV17</accession>
    <name>A0A4Q9NV17_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_977657</name>
        <name evidence="8" type="ORF">BD311DRAFT_732030</name>
    </gene>
    <organism evidence="8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
            <strain evidence="8">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143517">
        <property type="protein sequence ID" value="TBU23063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NV17"/>
    <dbReference type="STRING" id="114155.A0A4Q9NV17"/>
    <dbReference type="OMA" id="PTNMVHL"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="7">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU23063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU58071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="211" mass="23498" checksum="F8300FBA526C2326" modified="2019-07-31" version="1">MEVLNQRAALLSNYEVLTLLKELESDHLARTKTAIRIKKEEEAAGLPPKHQAPPDDVCENLRTVEVEAIQYLSADFQPTGSQTPEGITQLTRNLARWDLTKAEKLQIVNLAPTEPVELYVVVEELEDRFGNQMDDILNTVKETLREAAPAVNGTSNGAEPSQAMQVDAAVYSEYQDDYQDQDQWDYNANEVVFDDTGEGAGIEGDLDVDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW23</accession>
    <name>A0A4Q9NW23_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_978811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW23"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="37267" checksum="15986B45E3122533" modified="2019-07-31" version="1">MATKSKMPYVRLGNSGLKVSKIILGTMSYGHPEWNEWVLGEEEAIKHIKFAYAHGITTFDTANVYSNGLSEVILGNAIKELQLPREELVILTKGLKPIDAGIINQHGLSRKHIFDSVKASLKRLRLDYIDVLQCHRFDYDTPIEETMQALHDVVKAGYVRYIGMSSCYAYQFFQMQNYAITHNLTPFIWMQNHYNLAYREEEREMFPTLKHFGVGSIPWSPLARGLLTRPVDAESKRGNVDWMIGRYKAESTMKVVSKVEEIAKRKGVSMAQVAVAWVLSKPHVTAPIVGTTSLANLEDILGGLDVKLTEDEIKELEEPYRPLEVVGHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NY46</accession>
    <name>A0A4Q9NY46_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">General substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_915642</name>
        <name evidence="12" type="ORF">BD311DRAFT_682597</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NY46"/>
    <dbReference type="OMA" id="GVFVYYM"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000119">
        <property type="entry name" value="MFS monosaccharide transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF73">
        <property type="entry name" value="METABOLITE TRANSPORT PROTEIN YDL199C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="301"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="18"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="466"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU34617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU63643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="519" mass="57765" checksum="276E4AB5A7D28A94" modified="2019-07-31" version="1">MPPRSRSRLVGQPLLYAISVFASLGVFLFGYDQGVMSGVITGPYFRKFFNEPDAIQVGTMVAVLEIGAFITSVAAGQIGDNIGRRGTLFSGAVVFAIGGAIQTFTPGFWVMVLGRIISGFGVGLLSTIVPIYQSEVSPPNHRGALACMEFTGNIFGYASSVWIDYFCSYIDSDLSWRIPLFIQCVIGAILAAGSLVMPESPRWLIDVDRDEEGMKVIADLHGGDPEDLVAKAEFQEIKDRVIFERESGEGRTYANMWKRYKKRVLLAMSSQAFAQLNGINVISYYAPRVFEEAGWIGRDAILMTGINAIIYILSTLPPWILVDRWGRRVILLSGAVVMAISLGFTGWWMYIDVPETPQAVVVCVIIFNAAFGYSWGPIPWLYPPEIMPLTVRAKGVSLSTATNWAFNFLVGEMTPYLQEAIEWRLYPMHGFFCVCSFVLVYFLYPETKGVPLEEMDAVFGEEELEERLEDEASERGSLLSQRSSRSRRSHTRTPSHGLVSRLLGRKGRANYQPIEDSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P5S8</accession>
    <name>A0A4Q9P5S8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_818019</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P5S8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P5S8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF27">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="62"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="382"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="551"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="683"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="386"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU59092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="731" mass="79933" checksum="9553752A17FCEE25" modified="2019-07-31" version="1">MPPGSRLLKKSSASSSGFSDHGHGLQPKQLTKSPPPSPGAERKVRSPELWPYIPSSNPASQYSLLEKLGTGSFGTVYKAIHNDSKQIVAIKQIDLEDSDDDITEIQQEIASLAQCDSEYVTRYYGSFVVAYKLWIVMEYLAGGSCLDLLKAGAFSEAHIAVIMRELLLGLDYLHSEGTIHRDIKAANVLLSASGKVKLADFGVAAQLTSTLRHTFVGTPFWMAPEVIRQAGYDAKADIWSLGITAIEMAKGEPPLAEYHPMRVLFLIPKAKPPVLEGAFSLAFKDFVAQCLTKDPHLRPTTKELLQHRFIKNARKTSYLTELIERYQDYRTRSPGRAPQYYQATVRNSGAWDGTLRSDWDFNTIRTSSAMGSLRSMVKDIMPPGMEPDDDYDEVPEEDEETYEGDTIDTTAATTKGSDVPLQPTALGGIGMNADAGHSTIVIRSFSKSDEKVPSLMTDSGSDETSTGSPPPTTPSQSVESVEAQIADAVEPPPAYTGSVRSSRRASYAARNNVMTGTIIGEADIGTGVDTIRPVKKVDTVRSLRLSEEYVGSIRSREGSTSSNPPSSPSSTKGSHKRGATEAQAAGKSLVDDVLLPLLQKTTRDDMDAREIESLSMISRGFEELRDVNPELAYNLILDILAGINDNPAVRSHIQTQRSLFPHKRIIRRSEMTAKGLIVTEEEEISGLPSTSSPIQSPTQPDPGSPVRKSPISELLYLRWLEGLKLKWPSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P776</accession>
    <name>A0A4Q9P776_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_820745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145132">
        <property type="protein sequence ID" value="TBU57814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P776"/>
    <dbReference type="STRING" id="114155.A0A4Q9P776"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="471"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="588"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="655"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="167"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="655"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="693"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="856" mass="90923" checksum="A69DED77B9F9F2B0" modified="2019-07-31" version="1">MPSSALSVGTSQLQQTARYQDLRQTPPGQVSRNNAPPPPTSKSPDRPAAHAGPSNPPQAPEFSRAPAQPRSSNGNPASAPSAPSLSTFQPVSASAPPKTQPRPPTMSQTSLTTPPSTSAGPHNPSHREAVQMVAEAANAQARQVLDPIRQSVSDALTSAHVTLAQHLAQLQSMLVRADLRQAQAQAQIAALRDQNARLTEERDRAREHAERVKKDAEAAVEEVSKMKENVMPRLVIDHYQLKGEHDAIKAELASAQAANRELREKLQVQVQATLAGHAQAGSAQAVTSMFVVPRARPDEAGDVKAEQGVESGVQVKEERLAFGVGGPVKGPSSPSAVDAETAFALAQAINLRKQKQREQDVQRFQAMLLQLASGPAQAQAQPTQATVSPSHMLPTPPLPLRPGLNAAELGQQIAPAPCPDATQAQAVPSAAPVPKVEEEDGAAMLCAIPELGHVDVSGVLEIIDLTHEGEVTDSPMQLTGDLPSFSRRTQEDEPASESEERKRLPETGWNERQVTPNKRRRTEDHMVVDSFATLEPAVQNGPLAEQAAGDGAPLTDMNNSFLRSLIAVAESMAAEPAVSLPPVEFESATLSTGNHGGERDAGRPKTPAHATNDRDIAPDTQHGTAPAPSSFAVDVASPPQHVAMSDLLLSASSAPAYPSATTSSTRSRQVPADTAPVSNLVNSLAPESTSVPSVPPPTAVYTEPPPAASVSTSAIVPQAPPITPVVDAFANCNLSFPPPTNAVQLHTDTPESSPSKPAPPKKLGIAHIELIYQRLGEDGQYKCRLCDERKKKYPNAPTTRLAAHAPGEALVAHVENAHPATIEYYLQMTPEDIREQKQEIKAIEQTSLERRPRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAT6</accession>
    <name>A0A4Q9PAT6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_941585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145285">
        <property type="protein sequence ID" value="TBU51794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAT6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7736" checksum="63D6FB40DBEC90C8" modified="2019-07-31" version="1" fragment="single">TASYEPHFSCPLFSKGSVVSQASQKNLNREYVEDESFPRRLTLPLRHFVRGEECHRRPRGFEGELVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCD0</accession>
    <name>A0A4Q9PCD0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_952721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCD0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="15180" checksum="E551232F2AB07D9F" modified="2019-07-31" version="1">MRLRAKALTKSLDWPTRIYPECSEEYIKGQSRRFRDQYPDTWRYMQDASSRRDSSWNLHHTGVTHDAEIAVGCRRANGSVEFKLVSQLAFRIEDDEKSQERSVRVSAYFCLAGAWVDVGCWQPTQDRMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF61</accession>
    <name>A0A4Q9PF61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6535 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_140610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145210">
        <property type="protein sequence ID" value="TBU53600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045338">
        <property type="entry name" value="DUF6535"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20153">
        <property type="entry name" value="DUF6535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6535" evidence="2">
        <location>
            <begin position="41"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="456" mass="51369" checksum="F3A9F09CBBC87C02" modified="2019-07-31" version="1">MFDFRTLQGTLSRLPVSVKPPAMPIDEELGSIGQTGYYEGWTECADALRERDEDNVKAMSDELDAFLAFSGIFSAVITLFVGQSVTSLQPDNTQAAVDILRTISQQIGNQSAATVGLKTEPFQSSIIDIALNALLNAGLLCSLIASGMSLWVKQWLREYVLDEPSLPRSRVRVRLYRYHGLRMWHIRGSVACISILLQLSVLLFSTGVVMLAHKLNTTLSWILLALNGAWWAVTWGCAIVAAASANCPYKSPLSRAIFRLGYHFRQIFGSRVRFLRESNFGKYPTFEKRELEKTELHSTKLELEALTFANRELWGSDRLTRINECFREFKARERPLALKHIEKILRAHYSLETSADTFEWPGQDRLVATADKVVKQLMRIWCDIFVEHYGEKARVQSLYRLFYSVSQGEQHLSHTHYAQTEEVACGRPKVRGKSPIMSDGGVTVSVVPVNPCAIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PFT0</accession>
    <name>A0A4Q9PFT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_970484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145225">
        <property type="protein sequence ID" value="TBU53095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PFT0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="574" mass="63800" checksum="4807E144D0E69579" modified="2019-07-31" version="1">MDAQQPPHQHLAAMPVDIDGQQQQQQQQQQLQHTNPHFTMPAPVEHRPPMASGFATHSPPMHASLHALSSMYGQHQGNIAQPSMFQGNTSATMGMPMGLDPSAGLDPPRVPGGVRQPHMSVWPEATPVQAADAWSDYVPLNHHQYWELVRSARAQGGGAYNRVRDLLRQYDANGALGAFNYLHQLKMSWSDPHRAETQSQARRARDFGREARNSGMRNPSRMDPLERWLEYWHQYPDTLPVYLPIPPQLGRPTRDHTRGHILLRALIPKLKGTQQSAERMRFLEVTAQLFLIPGLYRRIVDEGHYSEGTEERLLPYPGQVTNVSIFDLAAWYAHCRLSAASIALMQPLTVRMRQFYERRDPNSGEAFLQWPLTMVEVTAVPTLAELALQVAALQENPGATTGHATAPPPLVIEGVDVDATMGEAQGVGEGQADEPGPSEEIIDQITTSSLTTTSQLCLIHWDVLSWTYLAGTLCSKEQEPSGGGARCIAADTEVWPAFVGMCLGEIAIFTLTFMKWYQERLASMRISVRTQALLHGLQYCLVPGALAYLLVKDGIIHILDDIERAYTMVDVVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG55</accession>
    <name>A0A4Q9PG55_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_1000831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145275">
        <property type="protein sequence ID" value="TBU51951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG55"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="335" mass="38074" checksum="9496785491A20723" modified="2019-07-31" version="1">MAPRMQYVRLGNSGLKVSKIILGCMSYGTKEWRDWVLPEEEAIKHIKFAYDHGIQTFDTADLYSHGLSETILGNAIRKLNLPREELVIMTKLWSPIANDFKKDFTEPSAKPEEAGIINQKGLSRKHIFDAVQASLKRLQVNYIDLLQCHRFDYETPIEETMQALHDVVKAGYVRYIGMSSCWAYQYYAITHNLTPFVSMQNHYNLILSYESPLPCKMFGVGSIPWSPLGRGLLCRPYNTEPTARKKSDDFQYEDAPFLPTLTSRIEELAERKGVSMAQISLAWCLAKEGVTAPIIGTTSLSNLEDILGALDVKLTDEEIKYLEEPYRPVKISGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG61</accession>
    <name>A0A4Q9PG61_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="12">ETF-QO</shortName>
            <ecNumber evidence="12">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_941082</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="12"/>
    <dbReference type="EMBL" id="ML145267">
        <property type="protein sequence ID" value="TBU52092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG61"/>
    <dbReference type="STRING" id="114155.A0A4Q9PG61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 12" id="KW-0274">FAD</keyword>
    <keyword evidence="4 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="11 12" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="588"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU52092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="628" mass="69259" checksum="B9E5F55BB3B73FBE" modified="2019-07-31" version="1">MLARCRLRPRPLLRSLHSTPSRKRQLFDPHSVERPTDDVDVCIVGAGPAGLSAAIRLKQLEQQHGRQIRVVVLEKGAEVGSHILSGAVIEPRALNELLPDWQSRNDHPIKQPSTSVTMRFLTQNSSFRIPQPPQMAKLGTYVVSLSQLTAWLGAIAEELGVEVYPGFAAAGLVYDNDGRSIRGVRTNEVGLDRHGRMKDSFEPGMEFRARVTLLAEGAHGSLSKEAIRRFKLRQGRDPQTYGLGLKEVWRVDPAKHEPGKVVHTIGWPLDTRTYGGAWVYHMADGLVSLGIVVGLDYQNPYLSPYRELQRLKHHPYFRDFLSGDSTRIAYGARVLNEGGLQAVPRLDFPGGALIGCSAGFVNVAKIKGTHNAMKSGMLAAEAAYDALATEDASQDKPTDMSAYDEALRKSWVYDDLHEVRNVRPSFNTALGLWGGIAYSGIDTLFLKGRTPWTFRNTSGKGDAAHTLTSRECEPIKYPPFEPPLSTDLLTSVALTGTNHAEDQPVHLRVRKYLAQGEDVGVEGSDPSKGLQTEKWIEDADVRKEHVRVNVDEYAGLLGRGCPAQVYEYVEDENADRATEPEAAGWQGKKLVINSQNCIHCKFCDVKVPTQDITWTVPEGGGGPKYTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG77</accession>
    <name>A0A4Q9PG77_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_786766</name>
        <name evidence="2" type="ORF">BD311DRAFT_602288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143451">
        <property type="protein sequence ID" value="TBU26058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145260">
        <property type="protein sequence ID" value="TBU52227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG77"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU26058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="58" mass="6545" checksum="C4E5C7C9DB741FCE" modified="2019-07-31" version="1" fragment="single">SGRDVSYKHGSQLTECSEGERRRQPQPFSWAGGTEETRGSHPQSPSAHLTHTTRLRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGN2</accession>
    <name>A0A4Q9PGN2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940229</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGN2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7921" checksum="21C73AAA8C5E7116" modified="2019-07-31" version="1">MSAVMACHSIRDSTDAGQPWIAWVSAASRGRADMNPALSRGLTTHDPVRLFWSFLDCYDRATEVTNSCIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGY6</accession>
    <name>A0A4Q9PGY6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_937240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145203">
        <property type="protein sequence ID" value="TBU53875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGY6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGY6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF26">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="76"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="337" mass="36427" checksum="8F50BE3695C483C8" modified="2019-07-31" version="1" fragment="single">VKIGSGRDPLSAVPDSSLTDAKFVWVEGIDESLYCGEIRRLGDITGVRPARIAGYWLLKKGAVWDGPKAKPGERTVLHLHGGAFYIGSANPSDITANFTRGLLEHSQSLDRVLAIDYRLTASAPNPPANPFPAALLDSLAGYLYLVQDAGFAPENITIAGDSAGGNLAIALVRHLVENPFPSLPPPGRILTVSGWFDLSMSRVGPGSSHLSNSASDIFGTLKPGRLFGEYGMTSLRGPLDFEVVKTNRYLSPSSLDCEPMKGKSLFEGFPETYVATGGAERALDESTALVERMKADGVKVVEDFPPDAMHDFVVFKWHEPERTEALIRMSAWLDRAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PH86</accession>
    <name>A0A4Q9PH86_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_831119</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145230">
        <property type="protein sequence ID" value="TBU52967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PH86"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="25900" checksum="70BAA641ED149F88" modified="2019-07-31" version="1">MPTHAVNGLLCVQWVESSCTQPILEDINAYISSLANATSFAYGFTGIQVTKPSFPGCGVIVGYPLALAHRLTIINRICAIVADTLLIILTWRSLGGGDVIRASSVLTGRGLIGVFLRNGTFLGILALNILILTILRQSELHNVTADIASTYVTPLSSILVSHFMLDLQEAYQKSNMVLDSDSPLNTLTSPNPGSRNFSPALGSFSAHFDNLGTNASYAERENAGEEAVDMTADPSTLGGAGPVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHH0</accession>
    <name>A0A4Q9PHH0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_981403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145226">
        <property type="protein sequence ID" value="TBU53092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHH0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHH0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041078">
        <property type="entry name" value="Plavaka"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18759">
        <property type="entry name" value="Plavaka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="691"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1140"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1197" mass="136100" checksum="0DE38021844B5FB0" modified="2019-07-31" version="1">MPDPPGIDPLPPPFEWPQDDLEDHAPESSRPQPHAYVEDAPEEPGPHARAGEYPPHSMDLPFGAPRPPYVDTSPNEFGIFRRYTSLPQRDPEEGLTTADFADSATHLRPPVNRQERNPLRALGASIAEGLGHACDVAAKTYAPFLNWSAFSLMTWQYTGSVTKSAGELQRLVDDVLLDPRFDQGDLMGFSATREKRRLDEYAGTAGAFSGGDGWHEVEVELHVPKERVQHESENNTESFFVRGIWARNLTEVLKTAFQDVIARKYHWFPHQLLRRRGPNAPLERVYSEVYNSDAMLEEHENIQKRPRNPEDSPDVEYVVAAVTVYSDSTHVAQFGTASLWPIHVLFANLSKYFRLKPTMFATHHLAYIPSLPPELFEWYKDIYGSPPSAAVIRLLKHDLMQKIWLHLLDAEFMHAFEHGILIKCGDGVIRRVFPRIFLYAADYPEKCLVACLKFLGKCACPECLIEKKDFDKMGTWTDLKHRVTKKREDTGMLHAAIAKAREWIFALGRAPEGSNIKATLLNQVSIRPTRSAFSIRFARFKQNCYDLFTPDLMHEFELGVWKSTFTHLVRILVAAGNDKIQTLDQRFSLVRTFGRGLIRPFGGNVSAMKKLAARDFEQLLICAIPVFEGLLPEPYNSLVLDLLFELAMWHAYAKLSLHTEPTLSAFEAKTVALGKAMRAFVRRVCPDFHTKELPRETQSRQRRKAASTPNGPGRRTAASEDDPSPKTKSFNTNTIKYHRLADYPRMVRRTGTSDNTNTQTGELEHRRLKSFYKRTNKNRTFGFQVAAEVQRQSILDRIARGVPVSSKRHRNQSTRAIKARHRRDLRVRFEEDQPLSASSFTDHHHMSLEQRYPENLTDFLQTNAGDPACKDFIRNLKTHLFGRLSGEEALLTDSEPTDVDLAQVRICSNRLYRQKVFRVNYTTYDMRRAQDSINPRTQPDIMMVAPDDSPHSYLYARVIGLFHVNAYLAGRDTSGMDDTQPRPYQVLWVRWFDVDVQAPGIKSRRLPRLKWARAGEDAFGFVNPRQVLRAAQLIPAFHYGQSDAALPGPSIARQADEDDTDWNNYYVGIFANRDMAMRYVGDGIGHQHTASIPVPPPEAEVNEEVEEDAPEDNVMAEDAPEDDAMAEDAPEDPRMPGDYDNIDSERDEDEADTSASNSEDEEEQSSEDEDDLGPEDGEDHDPTTDEYEYARLGYAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHW4</accession>
    <name>A0A4Q9PHW4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_939787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145242">
        <property type="protein sequence ID" value="TBU52646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHW4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="415" mass="46623" checksum="F0119948BE871EFC" modified="2019-07-31" version="1">MIRHLSLLRKTARIVSYASSSPCTLSRASHSAAALRPTPQEPVSKDESMEDYVQHAIRSLHPAFLSHADWVHFPALQDYCHVWDAYASSSSLSSSTYPSSNDRKHHNRPFAVFRLGNGKPIPAGLAGYFYYYAPGGPVPPTAGEIRFRVIPRGPPNLHLFNQSQNLLSDSERGLPWHLPLTTIAARDSYQVYREVLLRDGLVSPELLARAAEMGREVLGERSGGRKAQVVHGFRQPWFIDFGSKVHWWWFMGADKLHTTPPMPNILSWKVGQDRTPSPWLGTALCSFFPDAHPRLRGHRVVKIKVVKLLSPITPNPEFPEELRYLVSAPEAEPREGAFLRRGQPLWQMDVDREGVEKGRREGFGALFANLGLPPLRTDKALRQKVPGEELTSQGGLKGQSSEDREGRRTLRSLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PI06</accession>
    <name>A0A4Q9PI06_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_861387</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145238">
        <property type="protein sequence ID" value="TBU52756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PI06"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="53"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="649" mass="72556" checksum="FA328AD9B0B37321" modified="2019-07-31" version="1">MEIALGPTGEDVEVRSGVYHRQPQPGPPPLPPSSSSPMPFPIRLSHVNSMTPIHSLPVELLTRIFQLGVDSQPAPDDRDPCELTFEVTISHVCRHWRNVALHTPHLWTTIHFRTTPHMTRGNTYLARNARLPIDIYVDTCSEDAYAHRQDLLFREQFIPVFNIVLPHIDRWRELHLKVADLECKAGARKVLNTCGSAPILRTLQLWHVQNWQTPERLFTAIGPPPVVVFAGHLPSLKHIILQGVNLPWVNSPFLRNLTSIEYALHSDDVRMPFPLWRTMLAASPALERLSLHYSGPRARASGAVPPDGIEWWGADPPGPDAALAPGHVPPPSAAPVLLPCLQEIQLNDLESDYLIAVFKSIDAPNLRSLYLELDTEDQDFSPFVEFLASSPRRGASESSASNGDVPALNGQGALQARPKFARLEKLSVNRLVCSAESWKALLESLRALTRLEADFLSMHEGAFGVLFGTVRSEPPQLQPPHAHASPSVAVAVAVTRNGIGSEAGEDAAAPLPSKDKGKAKACEADLVLEVIPILPALREIRCAGVSSKEVARLAAHRRACGPQYRIRRWEVEEAMRDDDGLAFERELERVSAQWREEEHARERREGRVREPWRWDEPVEKVVWYKEEGDYDEEDEEEETGDEDEYGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIB6</accession>
    <name>A0A4Q9PIB6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin-like ATPase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_829382</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145204">
        <property type="protein sequence ID" value="TBU53821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIB6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIB6"/>
    <dbReference type="OMA" id="RWVWGKE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="455"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="677"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="640"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="704"/>
            <end position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU53821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="772" mass="82915" checksum="17B1F618086B2DCD" modified="2019-07-31" version="1">MPPKSLSTFFLGLELATDQLRASIVDENLELVGVEIVDFDTEISEYQTQGGIFTTPGDAYTTPIEMWLKGFDLILEKLSKNYDVARIRAIGGAAQQALVWWKAPVPPLHALDPRLPVHAQLTSQSFSLQNPPIAQDTSAHTHALALEAALGGPDLMAQRVGTCAHPSLVAAQILRVREAWPDIWARTGRVQMASSFLSSLLTGQMTGMGEAEASSTGLWAHAGAQPGVQSHWDEGVMEIVGGNREEGRRIWNWLGDVDVSGGRRRIGNVSRYLVERYGFDPETIITPFTSDYLSLYLSLCPSPSDAVLSFGPMDSLMAPAPNFVPTRFYNLYPHPAQDASEKKRYILTLTSRNADVPRALVRDMYTKSWSAFDRLVAIVPPGGSIGLDDKLFSFWLLQGDSYPYSHVKGIYRFETGVKVNEFRDLRANPRCLLESQILSFRVRWSRALPTGVFGTASGRARNTNSTPSPISGATQKRAPGVNNSNNMGLPFDPYDYSPLPARILATGAAANFPSIANLAGDVFNAPVLMPTTQIDAAQVIPHRNAPAPGFPARAALGGAYIARWVWGKEKGTPAGTGRGGFEEEIRRLLGKRWAATNGAPLRTNVNAPGSTSKTPSATGSGASTPYGHGSRSALGSSVLVEEEEEEIEEMERVQGGFGLGFSETDIARLRTVTSSTAGTTLSGSTLGDAPSTAFTTPDLGSLTSPNPNQGDPSSSSSAPSTLQPVTAMITSDAELQLGLAKVAEPDVDAFMSYAALVPEYCRLEGLLIKAIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJP2</accession>
    <name>A0A4Q9PJP2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_951510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJP2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="432" mass="46176" checksum="2F7F879787E8FCC1" modified="2019-07-31" version="1">MSQVYTGMQEFPDQASGNLQQPHYVGAVPEHYFAGHCDHNAYPIYSIAPPQLKCYNTNGVPDLAAFSDYGDFDAGSAFGCLHYLPPDAISSKYYALQDPNVYLADETQKPSTDVEAYATTASPITTEVFAKMEVDEPPMGSLTPRMGSVTPPMGSLTPPMGSLRPPCDLHADMPKLTETTSMGILATPTLAYPEHSSPVSALAPRPIPSPSPTPPCSVLPKQRRNRDDPGGDTGPVAQCSAQFENQTGSDYAEGARARVADSGDTMTCGGRVKGEDQPVVVPSQWKLGAILDKLRFPEYGGDWDALMCAINGREYQACMPRSDSPLSPDDMEQLMQLRVGLGLSAPGPPRTPTTPPTTPPINADEVLVYSPTTGRRIPVVAGPAGPILQLTKDLPSAKRPHKRGTTAACAFCRRRKIACGGPQEGDEARRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PKC7</accession>
    <name>A0A4Q9PKC7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_827772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145186">
        <property type="protein sequence ID" value="TBU54555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PKC7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10152" checksum="15F08F881AEDF25F" modified="2019-07-31" version="1">MRQLTCLVVKLPAETNAHLPEQEVALENAVRGLLAKLMPPNPNSSNLRSSIPVSYVYTEAMGSEGTLNAVVPALEWSLWRIRESSREFRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLU8</accession>
    <name>A0A4Q9PLU8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_969442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145175">
        <property type="protein sequence ID" value="TBU55106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLU8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLU8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="3">
        <location>
            <begin position="42"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="356" mass="39869" checksum="049262FA55B7F026" modified="2019-07-31" version="1">MDAPNISELLLSDMIMSNLSDLLHTFTVQGDWGFYLLRVNKYFKAASVTLLVLEAFSTLPDEVALVWTSDFSALNVLFFLNKYWPFAEEIIDQIMAFGVTSNLHLCMIHWGVLSWTYLAGTLCSEAILLVRTGAIWGWSKYIILLLGGGVASILLFCFYVVYTSNIHVQFPPESMMRMTGCIAADTEVWPAFVGMCLGEIAIFTLTFMKWYQERLASTRISVRTQALLRGLQYCLVPGATRSNLLTVMYHDGALAYLVVKAVWIANLLMTVLAPVELSTSLMMPLRIVHSTVCTRVLLNIRKFAAARRRGGTSLEQSRAWDLAAQSCPFPGEDRHDPPTHEDQPIPPAPRPMMISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMP0</accession>
    <name>A0A4Q9PMP0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_687385</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145169">
        <property type="protein sequence ID" value="TBU55404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PMP0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17856" checksum="2452F7E887C1828B" modified="2019-07-31" version="1">MLPSVPELLEILLRDILGRGEEETHVMRLIPPSWPETLGTILPEQRRPYTVFLLFVVLSRPHVLRPPLRPNADCRNDYCQLICFLKRGPEYHNARGGGSAIGMGAGRGALEIDVQLDRVYKVAREARKESILHRYIVVVGSTQGLYDRIVNVNSSTSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNI1</accession>
    <name>A0A4Q9PNI1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_950541</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145162">
        <property type="protein sequence ID" value="TBU55837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNI1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PNI1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="195"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="354"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="505" mass="54793" checksum="B6A75AD2FA899749" modified="2019-07-31" version="1">MRITRSATRMSTAVDANGTNVPVEETVTVVPKTNGKRAANTELHEPPKRARATKPSSNTPAEEEETTAPVPRAPTIPITPIPAADGEELVPAVLTFSFEVAKNHLISVDPRFEEMFKRVSCKPFEHLESVDPFRGARMQNPGSEIVTSIGRVVAEPSKTRMSGARGGREGLRLPPRNAGTVPALHYAKMHRDKVVSARAITHKFVRLFDPSIPEDVSESQYVSPRASRSDFFPSAHQVIAKDVATLRTAGLSGRKAEYVLDLAGKFADGTLSTRKLLEADDEELHKMLTAVRGIGTPLSAAVVDMFAMFSLRRPDILPVGDLGVQRGMLRWFISLHSPSHAVFIRQDKLNDQDTTDTQLTADSGTSQEISQSQNEVRATTAHASALPAAPDALAPSVQNKKGKGKAAKEAAVEADTGMVLPPAFTPSINKTLNMLGNPDEVGIGFEVPPLPEGLTVAQMKTRLTGKNKIKGALLTPMEMEALAESWRPYRSLGVYYMWALSEEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNT0</accession>
    <name>A0A4Q9PNT0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_932598</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145160">
        <property type="protein sequence ID" value="TBU55962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PNT0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="165" mass="18364" checksum="FE0D7113A6BE8C3C" modified="2019-07-31" version="1">MSARTSAPPISALRTLRCSRGSRTRTSSAFSSRVGSFARRMKRAPLRPPWQRHVQALPGAWRPGRQEAPAAWAVDIARGPHILSSSCEAIMQTHAVQQWLEGLKRQSEHEWCATCLDERIRVWEGARIAWWARLDAWLETGVGVGVSVAQMNVDMHAAFGGEIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PP02</accession>
    <name>A0A4Q9PP02_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_855668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145158">
        <property type="protein sequence ID" value="TBU56049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PP02"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040976">
        <property type="entry name" value="Pkinase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248:SF2">
        <property type="entry name" value="FUNK1 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38248">
        <property type="entry name" value="FUNK1 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17667">
        <property type="entry name" value="Pkinase_fungal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="289"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="728"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU56049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="863" mass="98126" checksum="187733717537287B" modified="2019-07-31" version="1">MHGRTTILDADKFLQHFVPQPTTGPGVAPLKKPASLFKRMKKPKNESVLYKELPKRLKRGFPGTMYGFVATPYKADRNTTSLLSPDCGMYPRPHVPRRHKGQRRDTFLATNWAHIELPIECKSNGSGDPFDDKQPNGEPKTAKRRDALGQILSYAELVLEYQQRTHLFMLVFFGKYYRIVRFDRSGIFATQKMDYLLNDRLLIEFIWRYVQLSPEDRGYDTTVLRIDQNSELAGKMRQRRDDLEKAQPDHYLTALWTEALDSRRPWWKVKVEDDITKKDLWYVVGKPNFQAPGVRGRGTRGYVALPLKIGEDGEQLGEKFVYLKDAWRVVAEGIMPEGTTLKTLNDYKDVPFIPTLLSHGDVTGQSTRSPVVWELLHPGKTCPLKQHQHYRSVVAEVGKPLSSFKDSYQLVKAVYHCALAHRAAYKHGYIHRDISAGNILLYPNKNGHWCGLLNDWELAKDRNRELIPRQLERTGTWQFLSVNILDDPGSVVVIADELESMFHVVIYYAVRFLHHNITANNVGQFLHDYFDDYAPHHGGKRCGPSKRLAMWMGRISLVNYHGRYGTGGTKLRFLRPPEDRAPAGEASQHPLNDIVSTLLSWFKAHYDHDLDEEETDERAPPAEDQPSSPDSLCRTLDDEFLDAMASGDSDEENAGAAAPSAKPIDTDSFRQAEKLRAEKERQLALNLENHDAFIELLRQALQHAKAWPTSEKTKDQRNRDFVPKLEPNSDDGEEEEAADEDEDDGADNDTDDDEEGERYQPENTGDEIDPEDTANDYDLVVEVEDDEDKGHMEGGVEGQEVGGCDDDSSASMHDSEGFPNTRDGMHVDDPAPRSSVRRSERVRMKRKAEEPEDAGSGKRSRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPG5</accession>
    <name>A0A4Q9PPG5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_634800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145155">
        <property type="protein sequence ID" value="TBU56211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPG5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="26318" checksum="31A57CC46AC795E3" modified="2019-07-31" version="1">MDNNANCLHLSSLVSSTLQFPVLPWEVIESVIDLCSGDKATLRAFALTCSQLHPRSLFILFTNVDIQSPNQLIHFYDAVQAQPHLRPIVQSLSFPWDGFSPFPLLSILPGLRHVTFDRNSLVKIDDTQLSHPTPLCGGQFATSLRSLTVRGAWFQTRTTFIRLLSAFPNIENLTCERLSIDAHAPLVSGNLSCRLQLQTLNILRCEDERVAELLFRIAQLEIVDPLAIPERFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPJ9</accession>
    <name>A0A4Q9PPJ9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_931746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPJ9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="62" mass="6849" checksum="B4027A6D48A3BEF8" modified="2019-07-31" version="1" fragment="single">MCSVVQCRLSNFSAIMFPTPDRPGNAAAVRLLSREDLSARLAQLQTHLEALPTSLPDNVYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPR7</accession>
    <name>A0A4Q9PPR7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_631192</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PGA52 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="3"/>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PPR7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PPR7"/>
    <dbReference type="OMA" id="WAGSKFF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018805">
        <property type="entry name" value="YJL171C/Tos1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018807">
        <property type="entry name" value="YJL171C/Tos1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31737:SF2">
        <property type="entry name" value="PROTEIN TOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10287">
        <property type="entry name" value="YJL171C_Tos1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10290">
        <property type="entry name" value="YJL171C_Tos1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020179910" description="glucan endo-1,3-beta-D-glucosidase" evidence="8">
        <location>
            <begin position="23"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 N-terminal" evidence="10">
        <location>
            <begin position="40"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall protein YJL171C/Tos1 C-terminal" evidence="9">
        <location>
            <begin position="115"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU56349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="377" mass="40284" checksum="2541060EF4D105EA" modified="2019-07-31" version="1">MHLSASVALFALFAIPVPFVRAQVKPNNLAAASTSGALSALKYTKVGSTGSYNQVTDIIPGTFPTCSANPFCITTPKQISGNLAPFDDEMTVVFRGPMNLYDIAVYQSTNASSASWNKVSSWTAGQQPSNLVFMNNNGGDASGEWSICAGSSQSYANGAWTDATTAPNKEVANGFLDEDHEMNIMTATSCQEISCAGFSRGTANHGWSGSKFFVFTFDMPSSSSSTKTPAIWALNAQIVRAAQYGCNCRGTGPQGCGELDILEVLNNDPSANINQAISEIYSPKGATGTGSGGFFARPTDGKVTYGVIFDVQTDQIAIQRYTQWDYTQGQITRSLMEGYLSAPALVVPFDGSGANGKREDVRSRMFGAHRRRHHSMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQ98</accession>
    <name>A0A4Q9PQ98_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integral membrane protein DUF92-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_931335</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145150">
        <property type="protein sequence ID" value="TBU56519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQ98"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020909892" evidence="7">
        <location>
            <begin position="24"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU56519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="277" mass="29489" checksum="1A7AC6DAFAB78E5F" modified="2019-07-31" version="1">MMSVRLSTFGVALIVFYLTGSRATKVGKSLKKQLEEGHQDAGYRNAVQVVCNSLSAAIAALGWSALYDPHSWVAQALRSLGWDAELGRHKVEFDIDRWCPLTPPVAASWSRALVFVTLGHFACCLGDTLASELGILSRSPPILITTLKRVPPGTNGGLSVVGTLASVGGGLFMGLTMAITLIVQSASCRAQWQQILFSLVVWGTFAGGFGSLLDSLLGATLQRTRYVNTTKRIWTEEAGALDATADVKVISGLDMLTNNQVNLLSSVATAVLLGFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQI8</accession>
    <name>A0A4Q9PQI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_854553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQI8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU56620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="72" mass="7875" checksum="6796E54F555B6453" modified="2019-07-31" version="1" fragment="single">MVGRGCGALLLPLGGEGLRRLGLIVLTEHLHLPLLRLLPLLAVPDPSRSLLTIVYESYPACFYLDSFARLTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PRD9</accession>
    <name>A0A4Q9PRD9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_822540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145143">
        <property type="protein sequence ID" value="TBU56943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PRD9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="215" mass="24312" checksum="5345DDF9281CDC5A" modified="2019-07-31" version="1" fragment="single">TNSQDIGKYASGILPEARSWNHVAIVWEDEVSQAKAQTLDERPSDDGDALKEKRSRTSPSRSTQRLAIHDFIQRLRVPYTFIDVGWWMQLYLPPHLRSRSPSPSKEMTWKVRRDGKARHILTTNENIGKSVARILAAPTTPIAAIVWEHNVSQTKARARTEPDTVGLKDKQTVSLNCKSNRHQYTFRTSNDTSDTHHDPTTTPHSSALLILPTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS04</accession>
    <name>A0A4Q9PS04_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_929839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS04"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="209" mass="23266" checksum="53A96A1F3A02682D" modified="2019-07-31" version="1">MASALISKLKSASNKPSARISVLARKAKAKAAPCLPRASTVVAGIKVTVAVAATLGLSVMEHAAAVKSNRKECKKISALTEEVASGLLSATKDVEEEDLDEITRLNLAELEWRMQTIGDIMSRMRGESFDEHATSLADHRRALQDAISKFQIMQLTRLDTRILRLEKKQDLMLKKDPIWMAVRGKVLRRVRSFEETYSVLHAQQVLFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS16</accession>
    <name>A0A4Q9PS16_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_930053</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS16"/>
    <dbReference type="STRING" id="114155.A0A4Q9PS16"/>
    <dbReference type="OMA" id="SRLHVCH"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="61"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU57125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="460" mass="50043" checksum="96A970CA84986F39" modified="2019-07-31" version="1">MSTQRVFTGYNVVLSDGQPQPATLIVDLTTGKIVDILGRVSARTDFPDVGDADWIDAGGKFILPGIVDAHVHLNEPGRTDWEGFWSGTRAAASGGVTTIVDMPLNSIPPTTTVANLEEKRNAARGQCWTDVAFWGGVIPNNQAHMKQLVEAGVRGFKCFLIESGVEEFPCVNEDDLRLAMNELQNTSTVLCFHAELDKTASTVAAPADADPTLYSTFLASRPQQLEVDAIALITALHRQYPSLRLHIVHLSASDALPLIRAAKQSGLPLTVETCFHYLTLSAQHIPHGRPEFKCCPPIREEANREALWAALLDGTIDCVVSDHSPCVVSLKKVEEGDIMSAWGGISTLGLGLSLLWTEARKRGVGIDRLVDWLCVKTAKHAGLDDRKGTIQVGYDADLLVWDPDAETKVTKESLNFKNKLTPYKGLALRGRVDRTFLRGLLIYDGAVNGFTDLEPVGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PS78</accession>
    <name>A0A4Q9PS78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145140">
        <property type="protein sequence ID" value="TBU57185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PS78"/>
    <dbReference type="STRING" id="114155.A0A4Q9PS78"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="205" mass="23332" checksum="40C2DAD6E509132E" modified="2019-07-31" version="1">MPSSSKNPDHTDVITTPTPGAAPADAQPPTTPDQWEQTLAQLRVTNEELQRRNAEAEKDRDLFRDLYTKASSHASEVTKENNELTERAALAETQTHDVVAMMKATYEERIHLLEQEDKRWKMQVHARLTERDGRLDEETRRRAALEPELRAENVRLREQLEHLEEVYARLEGLLEKMATQQIEETVILGQTVTDPALSTKGIGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSP9</accession>
    <name>A0A4Q9PSP9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aldo/keto reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_929418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSP9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF40">
        <property type="entry name" value="ALDO-KETO REDUCTASE YAKC [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="340" mass="37547" checksum="DF640405C694CCF2" modified="2019-07-31" version="1">MASPKLPTRKIGAAEVTAIGYGAMGIAAAYGDVLTEEERFKVLDTLYELGCTNWDTADIYLDSEDLIGAWFKRTGKRDDIFLATKFGFTPDPDRPVNGDPAYVHQAFERSIKRLGVDYVDLYYLHRADPAVPIELTVRAMAELVKQGKVKYLGLSEVSADTLRRAHAVHPIAAIQVEYSPFTLDIEDDTIGVLKTARELAVAVVAYSPLGRGFLTGKYRTFDDLPPDDYRRTVPRYQPDNFPNIVKLADGLAALAKKYGATAGQIALAWLLAQGADIVPIPGTTKIPNLKENLAALNIKLSPDDVQEVRRIAQAADATHGDRYPTDRMQYIFTDTQPLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU17</accession>
    <name>A0A4Q9PU17_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SART-1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_928070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU57991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU17"/>
    <dbReference type="STRING" id="114155.A0A4Q9PU17"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="331"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="669"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="427"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="714"/>
            <end position="726"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU57991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="783" mass="87653" checksum="C17DED919A08813F" modified="2019-07-31" version="1">MSMEESISLEETNKIRISLGLKPLTDDKAPAGDKEKEAEDNYAKQRERETKERESKAIQDRIAKAKNKRELNAKLKGATLGEAEGDVDDTLKWIKRSKKREKELAKKRQEELENMDKLLLGEDYTEKDLEGLKVSHDFEGLEEGEARILTLKDSRILDNEEDELQNIEMAEREKEKKNKELKIKRRDYTGYDDEEFSAGAVGMKRAVLSKYDEFLEGPKEIDFRLGNSTLSSRTKQEETEGAVSVNKSKLSIDYAKNIESADYLQPGDVGFKKPKTKKKRPTRRINVEESDIPPVNGEDQMQVDEKPIVPRPRNLDANFVDDDELQAALARSRRAKLQRPKKQSPEEIARQIAEQRAQSEAKEVIVVGDEEDDEDGGLTIDDTSEFVRGITYDPTAIKKERVEPSLKREASREPSRLPSAPPAPKPDDEDHPMEEIEAGEVIVKEEEDEEAMLNAIESAIKQTEAMESAQEGSSTDVAVGTAVEQTFGAGMAATLNILRQQGVLAQPKADQLERERVQLQRDLWLADYRRMVAHRELERAKMRGGNKDQATREYENRVREQQEARQNLEAFRNYKPDVNIVYYDEFGRELTPKEAWKALSHKFHGKGSGKAKTEKRLKKIAEERKKEAMASGDTPLSMNQAFQIRQEKTGQAHFVLSVGNRGAVPQAAEFFDSQPLTKGKTEKKNKKKQADKGGIPQLDSTGFMTLPAPVLNNGSPAPGTSAGGSPAPRPGFSRITSVAAEVETPKEGTPVPAERSKVVIGLGAKRKAAGDAQGTPPPKSQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PU61</accession>
    <name>A0A4Q9PU61_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_928187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145131">
        <property type="protein sequence ID" value="TBU57884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PU61"/>
    <dbReference type="STRING" id="114155.A0A4Q9PU61"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039254">
        <property type="entry name" value="Rds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38705:SF1">
        <property type="entry name" value="PROTEIN RDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021023444" evidence="1">
        <location>
            <begin position="26"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="297" mass="31742" checksum="FECB42127F4E6DC1" modified="2019-07-31" version="1">MVLTPHFRLFFSAVCAAAFIASAVGVPTLSQSDISLLQFALTLEHLENAFYTGALQKYSDNDFEAAGLSSEIRGRYEQILEHEREHENILEVVLGVDAVARCEYDFPYNSPLSFAALSGIFESVGTSAYIGASGLLSDKDVLTYGAAILGVEARQASWVNAAVLGRAPWNEGFDTPLSIDAAYSLTSTFISNCPSSNPPLQVQAFPPLTLSDASPSPGSSITVSYNDSNESCGLARYTAWFDGLQVEHSVLQEDGQTTVPPDLLGTAYVVVVCGLDTPSDKNMLSGFAVVQIPSDMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PUR3</accession>
    <name>A0A4Q9PUR3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_819998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145127">
        <property type="protein sequence ID" value="TBU58209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PUR3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="24"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="232"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="655" mass="74133" checksum="BB40F04AA425AB22" modified="2019-07-31" version="1">MWLLSTHRAELHFFPTANDVPRGYAILSHVWDHVEQSFQDVQALRDRYTATGLNPRDFASPKIRNFCILAEQHGYDWVWIDTCCIDKSSSAELSEAINSMFRWYSLAETCYAYLADVPSYSNDPAGSRAFRQSKWHTRGWTLQELIAPDVVVFLSSEWKVLGTRAGLAELLQVVTNIPVNVLRLQMELSSVSIAARMSWAAKRKTTRPEDEAYCLMGIFRINMPTLYGEGRQAFQRLQEEIMRRSTDTTLFAWGTPSERLPDLLWNLQDDLSMVHGHIEGSCLFASGPSAFRSSADVVFTPHLQNTSARWRLSKTLTVPTFSNNAYGVRAHLPVIETKIPRVIIAVLFCSSSTQRYGLLLHTCSEATSPLGSLYDTGIPTLDRQAALRLVPLDEDDDPNLDKVIDMSKGYVVAEWRDVYIRALQPPYRTIQRIPVNRNTSFYIPRWLLKEYAGQLIRQGSGPTQPGPLPATFLFYADPKHHSFPFLLNVGRCTYPSGTRWANVVRFENRSPTASQARLDIAPSHDCTLDHIRSWPDHMRDLDLAFSPPPDPWWSSDPRARNLATKYFTVKIRFTPSPINADTRLLHLEVGGDRTMVEGGDAGSDTRSPEAEIVPLPPLEVRRSQSGIGLDEQLQESEVLDPIMTEFERIHDGLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVB3</accession>
    <name>A0A4Q9PVB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_479614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVB3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="130" mass="14989" checksum="9EF03FA9F8DE0237" modified="2019-07-31" version="1">MAPVSSRFIFCVHHSQPKSCLSCSMHVLSSIPRSSFRRRYLPSACLRFRQLVLTASLTTQYSSPHQENVTDLYRYLGYLAKYLKYPKYLKYPKSNGLGQVGWVDLAKYQVLGQVLQVPVQVHAQVHCEMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVJ4</accession>
    <name>A0A4Q9PVJ4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_927098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145124">
        <property type="protein sequence ID" value="TBU58510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVJ4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="7226" checksum="47C300115E8386CC" modified="2019-07-31" version="1" fragment="single">TARYQPHSSCPLFSKRSVVSQTSHKNINCEYVEDESLPRRLTLPLRHFVRGEECYRRSRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVW3</accession>
    <name>A0A4Q9PVW3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_818970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVW3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="65" mass="7434" checksum="AA28FE7E3CB8EDE4" modified="2019-07-31" version="1" fragment="single">YSIGVEELMDGLRNLVVFGKILYLVCALRRLSDRISNCICSCTWGTPAWSLIQANEHMMMRLIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVZ1</accession>
    <name>A0A4Q9PVZ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glyoxal oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_455342</name>
        <name evidence="5" type="ORF">BD311DRAFT_767389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143490">
        <property type="protein sequence ID" value="TBU23965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVZ1"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02851">
        <property type="entry name" value="E_set_GO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.80">
        <property type="entry name" value="Galactose oxidase/kelch, beta-propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037293">
        <property type="entry name" value="Gal_Oxidase_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009880">
        <property type="entry name" value="Glyoxal_oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015202">
        <property type="entry name" value="GO-like_E_set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208:SF96">
        <property type="entry name" value="GLYOXAL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32208">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07250">
        <property type="entry name" value="Glyoxal_oxid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09118">
        <property type="entry name" value="GO-like_E_set"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597652" evidence="2">
        <location>
            <begin position="19"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="Glyoxal oxidase N-terminal" evidence="3">
        <location>
            <begin position="70"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Galactose oxidase-like Early set" evidence="4">
        <location>
            <begin position="447"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU23965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU58660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="558" mass="59601" checksum="6320108353C9E603" modified="2019-07-31" version="1">MMRPLLSLLSLLASFAYAAPAAPDAPGWQFTLKGNSGIVALEAIVVNPTLVLLFDRAQNDPLQIDDHPAWGGLWNLEHNNITALEVVTNSWCASGAILSNGTMASIGGDPTGFPGNPVIKPGNQAIRLFEPCTSPVGEGCTVIEDPNLVLIEKRWYPSATRIFDGSLLIVGGMHEQAAFYNTDPAASFEFFPRKEQTSRPSAFLERSLPVNLFPRIFALPDGTVFMVANNQTIIYDIEADTETILPDLPNGIAVNPPSDGSAIMLPLSPPDFTPEILVCGGSVFDQTLTSHNFTAQHPASSQCSRITVTPEGIAKGWEVEQMPEARVLHELLHLPNGQILLVNGASTGFSGWNSVNDTVGNSNADNAALVPALYTPSAALGQRFSNAGMPSSGIPRMYHSTATLTPQGNVFIGGSNPNNGSNFTTGFEFPTELRIQTLDPPFMSMERPKILSAPEKLSFGKRVSVPISLPNSLNRQDANVQVSLMDLGFSTHGFQVGARLVFMDATISNNGKTLSFVTPPNGRVYPPGPATIFLTVDDVSSEGVMVMMGSGNPPPTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PW62</accession>
    <name>A0A4Q9PW62_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1038994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PW62"/>
    <dbReference type="STRING" id="114155.A0A4Q9PW62"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="1">
        <location>
            <begin position="9"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="345" mass="38038" checksum="5FA80AFE282AB330" modified="2019-07-31" version="1">MAGKISIFVTGVTGYIGGTLLVRLLNHPDAGTFDITALVRNSEKAQILESKFGVKTLIASHAEHDRIEEAVAANHIILQISDSDDEPLTKAILRGLKRRHDKIGDLPILIHTSGTGLLIDDARGEYPTETIYSDLNVEQLKSIPPTAYHRNVDLLVVGADEEGYARTHIVIPSTVYGIATHPLVKAGISNPHSIQIPSLIRFSLARKRAGVIGKGLSLWPNVHIDDTADIYIVLLDSILHHPDTTGHGWEGLYFGESGEHRWLDISLAIGRAMYELGLADSPEPTPFSHDEILKYFGSEWRGYLFGTNSRARADRTRALGWKPKHSTEDLLASIKPEVEVYAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWP4</accession>
    <name>A0A4Q9PWP4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_429599</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWP4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="156" mass="16590" checksum="951280B2788F230A" modified="2019-07-31" version="1">MTRAAGGRSASTDIDAITLASRSVHLDGSDSSMPPRRWHVGPRLCVPGLDRAARERSSNDSVFSSSHPAMYLHLPRTSAAGQVIASISLVLAFVLQDTSRSRHAGRASVIAARSHEVHVYEQSSRQMVASHCLSVAPTGSAATFTEAVSELSPRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXU3</accession>
    <name>A0A4Q9PXU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-N-acetylglucosaminidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_817635</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXU3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020950507" evidence="2">
        <location>
            <begin position="22"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="4">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="3">
        <location>
            <begin position="121"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="5">
        <location>
            <begin position="467"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="750" mass="83102" checksum="F5460C91631F80CD" modified="2019-07-31" version="1">MISRTWLLALWPLSFAAGAVSRTTSLDGIYALAKRRVPAHAESFSFSLSTGEADSFVVSDVPGGIHVECTTVSACARGFYTYLTQYGCTDIWWTGSRLGQLPPDLPKVGTPIKGQAIVPYRYHFNTVTFSYTTPFWNFDQWELELDWLALRGVNLPLAWNGYEYILIETFREVGLSDADIFSFLSGPAFQSWNRFGNIQGSWGGDLPVTWVDDQFQLQKQILQRMVELGMTPVLPSFTGFVPRALSSLYPNASIVNGSQWEGFPTALTNDSFLEPFDPLFTTIQTSFISKQREAYGNVSHIYALDQYNENDPFSGDPAYLANVTAGTFASLRAADPDAVWLMQGWLFFSSAAFWTNERIEAYLGGVPGNDSMIILDLYSEAQPQWNRTSSYYGKQWVWCELHGYGGNIGMEGDLDALTQNPIAALHAPGSSMKGVGLTMEGQEGNELVYDILLDQAWSSAPLNLSSYVDQWVARRYNVRRLPKSALDAWRTLATTVYSNKDSGTQAAIKSIYELAPALTGMTNRTGHHPTAIPYDTNSTVLVAAKALLEARSENPLLATIPEFAYDVVDVTRQLLSNRFIDHYNVLVATYNSNATAPRNVAAAAGPLLALLDDLDELLATNEHFLLSNWIADAKRWTHGADRAAYARLLEYNARNQITLWGPDGEINDYASKAWAGLVRTYYKPRWEAFVEYLAQTKEAGAAYDAHVVSAKMIAIGQQWSNGTWGTGKGEGWGTRGDTSAVAARLVEKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXY9</accession>
    <name>A0A4Q9PXY9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_876802</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXY9"/>
    <dbReference type="STRING" id="114155.A0A4Q9PXY9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020873661" evidence="4">
        <location>
            <begin position="28"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="909"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="810"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU59617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="947" mass="105201" checksum="863A64823C570A0A" modified="2019-07-31" version="1">MGYTKRKSRKASLAAFCVVAFAALASANDTPRKHGEDVEVIDPAVEASRAYKQAISTLATLTALPPMQSEEPAHHSTSVPLSSFLPSMQGQGPIASALRILAKLRNHSWLPSVVTDLLGRELTNGRKKDEELKGRAVKVIDLLQHAAELGHTDALYTLGQVSLFPPNSYFPSNPTAAYESFQTHADVTGNASSQALVGFFHSTGYHSVVPVDQAMAQLYLTFAAHGNHKGAQMALGYRYWSGIGVAENCMAALDWYEDAAEQAMAKFLSGPPGGRTLPLQPPRLSDLDGGVYGPGASVASTGLNAGRAVIKTANARAAGETWDDLLEYYLFNADRGETDFAYRLGKIYYQGSIYGAPGGAASGGDGASIVPRDFHRARYYFLRIARQVWPRDPANPRQPDRPSKEETPVQSGYAALAAGYLGRMYLRGEGVKQDPVLAKMWFERGADYGEKESHNGLGIIWRDGLVDGKKDVKKAMAHFAAAATQELAEAQVNIGKYHYERGDLKLATAYFETALRQGSPFEAYYYLADIQGRQARSTMLPPEIAGSSCAIAVSFYKLVAERGTWEEDLLRDADYAWSLGTERGSEMAMLRWWIAAERGYEVAQNNLAYVLDQDKSILRFTRFAPQSPSNDTARLALTQWIRSAAQRNVDALVKVGDYYYHGLGVPDESESVRWEKAAGYYQSAADTQMSALAMWNLGWMYENGIGVPQDFHLAKRHYDLAYETNSEAYLPVLLSLLKLHARSIWHTVMGGENGLTIWDSDEDNARSYYDQPEIEGDADQGPKQPSLDEVDEFADDGAWYMGKARDEFNRRKRGQHDDRDRRAAREEEDPVQWARERRQAEAAERDREGGGDFGPEDYFDAAIRGQRYREEEDVDEFAETMLLVVLCLMVSVLLYVRGRWVDRIRREEEERRRQGGGGQPDQQQVQGANGVFPPPGDPARDDWAILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZ75</accession>
    <name>A0A4Q9PZ75_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_923902</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145109">
        <property type="protein sequence ID" value="TBU59876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="114155.A0A4Q9PZ75"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1343"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="590"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="640"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1602" mass="179349" checksum="3A8E566706DBAAC2" modified="2019-07-31" version="1">MESQILCLLASWIERAFDGFALTRSDTNTHEDRLARQRSVETLTALLIRLVSKPEVVSRITEDDTRTIVELWERLLDKALSIPPDFTLGTPSASPLLEPQSSKTITPPKLPLSHRRHHSSTSLPKLSLLKQPADIVVDAYMTYLSERLVALGPIYLSRILPLLLRSLAFYMSPLPRVSLEAGAPHQHTLEQQVWTLLNQLVTGPYASSSRQLLKRHLFPSPELDFHASAQVSLGALRAIRMCIREALQSRLARALITLTTSMDYSPAGAPTHLAVERTIMERAWGKDDSEAWELIRFANVLSRASRAWIAQLPDPSSADRSQQQKEAVLHEIAAIIKDTIQTIALHQEMDERGGNVDVDDEEIEAVGRITRELVVYIRSLKQPDGSPAQISLDNPDRSISFLSTMSTILAQDLKTTLLFPVLPSIILSIADHLPDRDLSHLLVTMADRQCLSPTALTWLEHWRSILTMPDLFASSRSSTRQHAMGHLQAVWEFVKDIPAYRKPLASLVFEIWKQHTGDELEDNPALVVWNVLADEAVLRLVEKHAEDSSVEACEEEEQVCEEILDFFLTMAHELRLDDEDDAASILTMESSAASPPAIPGPTNIATTSPILSRMSSDYPSPQREKEAGALPSFSNLLSQFTSGTRSHSKTRRATNDMPTPVEMPSPALTAVDVAPSTPRSVGAVIALISVFSQLVFTPLAHSAHILWHARRVFRQLVELVTAAGCIRARLTALQFLVRLRADRDHRVYFAKAEYDKDGNIASLAALISRAETGPGTVEDLLRDDDLRRARARVPQERDGRRLSRGRGQPRMEASRSRSRVPTRPIPTPMLKLRARDPMWSIPETLSFTVAASDVSSEGFMSYDPSRPDHVDSILQSSLYLAKLVEVIETEREWEILSYVLCHLPTQLANKHLFCGPRSKKLIGKLLAALCSGISEGSLAKQIERWPDGIISRDAQGLAFHTLTVLISYQRCFDSPQPLHQLVEVFLLGLSGQPSTQKCCLNALSLSAFELQSSMAKYLSRIMEKLSQIMSNPAMAVHIIDFLAIVGSRPSLFVNFTENDYKMVFAVALKYLEHHNRRDGSLAISWALSQHVRIMSYYIMYVWFLAIDIPDRQKHVSYIIRQLLLANGGKVEVDAPTEVAFDWLARYTYASADPRPAKSTLCEIVMNPTLHSRSSEPATSEKTWVLGNSVVTIRVLERRGWIEVLSRRASGLTKFLVRAENVPMIPLGDVDPDLVSVSAMLMMDRENDGEVAGDETPHELNGHGQPNLDDVKLALAKSAQGSHSIPPPDPITGYVWSRSAPSQRRKEVSIEPSYFALQLSAYPDKQPVNRGRLVTERSKLASFFRTFDRMPVIDTHKVGVMYVAPGQEHETEILRNTHGSPAYTRFLEGLGRLIYLRGQVDVYDGGLDPDVDGEYAYAWWDDIGQILFHTATLMPTGDDPNCTSKKAHIGNDYVRIVWNDSGKPYRFDTLATQFQFVNIVIEPHSRGAIAAFSNNIHEHEYFKVTVQRAPNMVEFTPIGDFKLISATNLPHLVRQLSLLADWFSSVWQSTGGDTKRDEVVTNWGSRLAAIQRFRDQVFPAEPPLEPDDTLTGQQRLRDFTAYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q096</accession>
    <name>A0A4Q9Q096_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q096"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU59984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="88" mass="9228" checksum="E6B930FADAE74A51" modified="2019-07-31" version="1">MRVMGEATPNLVRALSNMRPESIPIATTITGSVDSSEDTPSEADPSIPALDARISGEADTAPMDASITSQPVWESLQRAAQFLVGSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0A9</accession>
    <name>A0A4Q9Q0A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_328952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145105">
        <property type="protein sequence ID" value="TBU60360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0A9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="108" mass="12016" checksum="F0C353DA44E777D9" modified="2019-07-31" version="1" fragment="single">MSFSTFPSLPPELEITIIDLLRDDKASMSACSLVCFRWLAVSRTHLFHTVTIYHSPPTHGRAGTLTKFLQCLTNSESPSRPPPAIGTYVRKLTMNGGAHNSRVTLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-10-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0R7</accession>
    <name>A0A4Q9Q0R7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_814796</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0R7"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0R7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="266" mass="29144" checksum="2006E032AB840D25" modified="2019-07-31" version="1">MKVTPRPNTERGQRDLGWLKAFHTFSVPGFDRPDHERWGPLRVINEDRIAEGTGFGLHRHQDFEIFSYIVGGELEHRDTMNHNEVLKRGDIQMTSAGSGIQHSEHAHGAHSAHLLQIWAFPTATGLAPKYFTRTFSDAEKADKWVCVVAPAGVEGVVEEFSAKGPAPIHSPLTLFATMISEGQHVTHAFLKGTEGKERKGYLQLSQRSAYNTGAASGAHVRVLGAERGPVELREGDGAYVVATPGEDITVENIGQGVAEVLLFDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0S5</accession>
    <name>A0A4Q9Q0S5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_947153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0S5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="471" mass="51752" checksum="4A5E8392BBF6EEF0" modified="2019-07-31" version="1">MQRIRKLSNDLKEALVPKTDKTQPHRRPSYRGGQPVQIGDIRKTANRSLASLDRDAMASGDLRETRAAVEQWRQDSFKEATRLDREQRAHANSVAFPSSSSRSKPRTKAEEKPVPVPSIDPRTDWCHSEHWLPGNHSDGEVCTPYGISPAVLPANRPLPPAPVPVKKLRRRCPPAPSRHFVLTHSTPAVPSRAKTGSSSTNNRDPALQVDAEVSTSHSTQSQGGEPSWPPNGPATIKRQQRARGSSFDNLSRSQSDRRGVRTTATTSDAVHARSSSEPQMGHGADTPSRRGQRMTDTVLKTLPDPKTATGKAHPSTSLHNPASSSARLKAALPVQELSTARSVHVEPTGLGRAKSHKAMIVHPSPEPAPPLPSPRPPTDIWRDAPRPSRSTGAEKKTYGHRDALSKRNKEPEVYYITMRQVAEKENKRTQKKLTDELAKWAPIPEVVPEASFATNGTRPLAVKKRSAMFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0V4</accession>
    <name>A0A4Q9Q0V4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_922052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0V4"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q0V4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="90"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="229"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="329" mass="36912" checksum="7CD11933B8DD811F" modified="2019-07-31" version="1">MSDQIELASPPFDSVSSVRFSPTSPSHLLVSSWDTTVRFYDIATNEQKSKYDHRAAVLACCFSDATHGYSGGLDTSVRELDLESEKINHLGQHSDAISSMNYSRDQNVLITGSWDRTVRFWDPRASNQQQSSHDLPERVYNMDLVNHILVVAMASRLFHIYDIRKMDSPAQTRESSLKFMTRALACMSDGQGYATGSVEGRIAVEYFDPSPQAQEKKYAFKCHRQTIDDVDHVWPVNALAFHPIYNTFASAGSDGTVSIWDHKSKKRLRQYPKYHSPVPSIAFNCDGTKLAVGVSYTWEEGEEGAKTAERPAVFVKNIGEEVKPKGWTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q134</accession>
    <name>A0A4Q9Q134_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_922254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002376">
        <property type="term" value="P:immune system process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06008">
        <property type="entry name" value="NF-X1-zinc-finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046439">
        <property type="entry name" value="ZF_RZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF445">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20173">
        <property type="entry name" value="ZnF_RZ-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51981">
        <property type="entry name" value="ZF_RZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0391">Immunity</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="31"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="856"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU60872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="2246" mass="251630" checksum="1C32BBAC1A0A39D0" modified="2019-07-31" version="1">MAQHQRGVCSLYGTPRGCRFGNRCKFSHDLSGSISPRGPSSGPSSPSRSRSQTPAAQTPGRSPSGRGRGGPGLQGVPRNVCQYFWTSGACDRSFECSFRHVRGNGATDAQATAAHQDEDEDGVVDFFSPEGLAASAGSVREDRWHNLNPSEVHNHLKEFVRPGYQFDSAAQVQGFVRLLASVNDRNKAWTTGSAQEFLEFVVGGNLLVRLGDALRFEPVSATYHYGVLSFQRGYFPIFQFFSSDLVLKSTLHKNINLLFAVLKNNHEVVFTTLRTCLFSMIQNRSWKDPSPSLHDENILDGVAVFRTLATVFLQYFNRYKDAIRSNSDIPDFISQFSEWFDTWADGVSISPPRFEDPIASAPLNNRRLTVGHIQEDIDRLIAIVERETGTVLRLRKGPPKSTVTAAQRSQARIAQLAQTYDPPGVLRPGGPRHDNDFLDIEEIRIAPTHDELFCPVQPYLPVFSRDAPHHLPADSMERHLDIQFRLLREELISATRASLAALHDDLLKIWAGNRAKKDKTQLETLIAKNGGSYRTTGRDSVFFQLYTNVEFVGRPPEATRKGVSVGLVLDAPPNGAARDKDSKKRVAYWEHSRRLQGASLVALVAVANRSFRVYLGVVSSYGKDISESAKHEQGRIQVRVSFFDPDVELMALRRDRLCTSKSNFAVLVDNSVMFESVRPFLDKLQTIEPTEIPFSRYIASGGPLTDVQVLPPKYAQAPGFKFKLQSLAQPRRSISDLDVSNPLAVRRARDELKRLSILDPSQAEALVDTLTREVSLIQGPPGTGKSFTAKEILRVLFASKIRPIVLIAYTNHALDHMVTSVLDAEITQKIVRLGTRSADERIAEYTLDKLEKLASEATLNRSMKRQYAKMKELEERLTKTMNSILLPLLTWEKIEQHLDIHYPDHADSLRIPPFWIAEFASQKWAEEDQEGEFQEVTRKGNKKKTVDKTVARTLYGVWRSGSDVHFLQQQPAAPPTSKKGKQVTDLSIQAQSLLANPSAFFDSLGFAGLIPPIPGKNRPLDELLRDPRLWQMSLLERARLADEWEKKIRWLAYTSQQDHYKSLKEEYREACKEHDDMRDEVRRRLLSQTDLIACTTTGAATLTSLLSSIQPKVLMVEEAGQVLEAHILTSLVTSVRHLICIGDPQQLRPTMATFTLSMDSGIGNELYKFDRSLMERLSDVGYPMSQINVQRRMRPTISHFIREILYPKLEDNEIVTRYPPVQGMQKDVYFLNHLNKENGTEDSVSKFNTYEVDMIKDLVLYFLRQGAYSGPGDIAVLCAYLGQLQKVRAALRDLKIAVSVDERDADQLARQGLDEDVEFQEVVVAKHIRLGTVDIFQGQEAKIVIVSLVRNSGQIDTESASIGFLKSANRINVALSRAKHGLFVLGNAANLRKNQIWSTILDEMESRDQIGPAFPIVCPRHPEQVQLVSKPGQLPLYAPAGGCVLPCNARLACGHICPSACHAVLDNHRSVRCMEPCNRTPCPRQHPCSRRCSDDCGRCEFPMYSVTLPCGHTASKVPCHKLQDLYSVQCTKQVLKKLPGCEHSAIVACHEDPANAWCSEPCGGKLQCCSRTCKASCSDCRSLTVQRTQPAVGKMSRTYHIGHPCERLLYCQHQCGLDCAREHQCNTKCSQTCRQQCVHHKCAKPCSEPCAPCMEPCQWSCPHFTCPVLCGSICSRLPCDEPCMNLLKCGHLCPSVCGEPCTSQKCVVCLSADGRADIVDFIMQRRLEDVDLSSTDISDRLITLACGHIFTVETLDGHCGMHDYYDIDQMGQFLSTKSPPVNYQTPPTCPTCRGPITALRYGRITKRATLDILEQNVASTMSSALDECSPLISEYANNISDYQQQAKKLATEAGNEDESTKRKEISFTENGPLPASAFDLQAMQEVHGIPQEEARAWYQVVKTLVNTYRRVAKVAATRGAHVKAYEAALSTLFRLEMQAIAEDPARATDTPEPMALVIVDRKIGQPPPKADVRFQIEAYFLSLELRSLMAEIARSRIEGLSVTSNDPDVTQHRELWTLFVSFLYDSCIADADKAINIAKNSSASRQAARATVHKLRFAFEAFRWTILCERSALFRAGALDKAERERLCRKVTNYKRLLPQISNLIEQTYIRSRPSQTTADLKKERQWMNENCRTKVEAWERECTKLEEFVENGGFYQPMSTQEREEIVKAFGFSHRGHFYNCENGHTFVITECGGAMEESKCPECNAPIGGSSHRLTTSNTRATEFEAIARRQGSLNGVFDWTRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q335</accession>
    <name>A0A4Q9Q335_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rec8 like protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_175594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
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        <property type="protein sequence ID" value="TBU61652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q335"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q335"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="616"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="278"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="506"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="687"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="714" mass="77524" checksum="7750CE525A64A1C0" modified="2019-07-31" version="1">MFYSEAILSRRGPLAKVWLAAHMERKLSKTQTLQTDIEQSVDAIMHQEIEVMALRLSGQLLLGVVRIYSRKAKYLLDDCNEALLKIKMAFRPGIVDMTEDQLAVNQNAITLQSNNLDLDALLPDLDWDTADFETRNVQPGGQHIARAADITLGNADLQFDFDDVEYGFDLGPSDGIGSQDYDIDLNLDFGDGPAAPAARTPSRMSEDDDMSVEMPRERAEPRPYRESIGSHVLGPQGVDDLDLLSVRSRAQSENPFAADIDMGFGPDDAGMDVDLGISFEDEPLPLPDAPLSEHAPTPRLTPSRASSPLTEPPQTPPPDVELTPRVVPEEGAKKQRKEKKQIIDSVTELADGPGARVGRGRNAGLGAPVDVSGIVTEHATLPRSSLVMRLLEIRDDPLAHFLPTKTTPHGTFFFAAPPGLVPELADMFMRPITNLSAGKRRGASPEKPPSKKRRVDGSVVDDDEIEQARRESRAPSVALGSDVYGRASIGPGADFTFDTGAGIEDFQMDVPDFPGPEELQRERSGSLAPSELTRLSEAPPDPLLEEGEESHADATCPIALFDDRTVASQSQSQGQSQGTSEPSDDGKGYSKNTVKALAVIRRELQPNAEEREEDRYMSFNHMAQKASRRAAAAFFFELLVLGTRDCVKLSQAEPFANIEVRAKDKLWERQRHGSTAPSSANGFPRMSQASSAAGAGPSRRQGSAAPSIASAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3Q0</accession>
    <name>A0A4Q9Q3Q0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_812466</name>
        <name evidence="2" type="ORF">BD311DRAFT_673354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143497">
        <property type="protein sequence ID" value="TBU23714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="protein sequence ID" value="TBU61795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3Q0"/>
    <dbReference type="OrthoDB" id="2732296at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU23714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="193" mass="22276" checksum="94C24BDF9D9BD111" modified="2019-07-31" version="1">MSLVPTLGVLLVGDLCSVALYGLTTLQTYLYFNSSWITDTWKLKSFVFFIWLLETVHTFLICAYIFRALVLEQCNPSSQLLTRVSDDVTTLITQTVIIFSIHLFYIRRLFILSERMNRRFHLLIIGGITLLASCHFDMDRGDNATRFKYPKFSEFHRIMDYYAASLAVAAACDVTIAVFIWLILKSRQSSMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3W7</accession>
    <name>A0A4Q9Q3W7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9Q3W7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
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        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
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        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
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        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="258" mass="28617" checksum="AAC1CCCDC8B64DE1" modified="2019-07-31" version="1">MSSSGADDSVGSIIDLIASNFVQACGDYSVFVLICYDHFITFDREVNFFWKGKLTGAGILFFCNRYLGLVNYALQAFSLPSPTLKSCTITSQFITAVSVSIYLPWAVFSALRVYALSRWKSISIAVLLLSFGPILVNTILFFGISDITGAMDPILGCTILERPVNHLQDTLFIVFSRPSLILADCISLAVTMLCTHKTRNIHLAAQHQTLEQVLVRNGTKYFLLMLILNVLHLVFTVAPVEAIRFDQLASEIVTFEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4V6</accession>
    <name>A0A4Q9Q4V6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphodiest-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_965770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q4V6"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q4V6"/>
    <dbReference type="OMA" id="DEYVSRD"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="532" mass="60458" checksum="D3157604295FC56A" modified="2019-07-31" version="1">MKPEYFKLASASDSPRHSLDDEERKTLISSEQRRLDDAQYDEEETAELPPPSRSRKCVVFSVLFFSLLLLSIAIPLRNFLSGPRASDTKPQLNTQGLLSNGTHDFKKTAIIVSIDGLRADYLDRNLTPHLLAISKDGLRAKSMQPVFPTLTFPNHWALMTGLYAESHGIVANDFWDPATDRQFHYNRIESAWIADWWHGEPMWETAEKAGVRTANLMWPGPPKTTSGASPTYFVPWKDHVPLKHKLSQILSWIDLPVDTRPQFIMAYEPSLDQAGHKYGPTSKVVDQVLKQVDVFARDLHDEIEARNLTDIVDIVFVSDHGMTDTSHPELVFIDDILGDGYKHIKHEDGWPAMGLRFDTPENADKYLRVLLNASQLSDGKFDVYTHETMPKRWHFTNNERIAPIYIVPRIEYALTNRIENGSGMNKGSHGYDNQYKEMHAMFVAHGPFSAVVKAIEADRAKSSASSPVRRLASLFGRDLTRPNKGWHSTADDAYVMETFENVQVYNLMMKLLGIEEYAAPTNGTKGFWDKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q539</accession>
    <name>A0A4Q9Q539_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_918833</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q539"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU62200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="517" mass="58206" checksum="800D14A58D141EB3" modified="2019-07-31" version="1">MLSMNHLSIILLLGGLVVLVHISGIGRARRLPVPPGPPGLPIIGNVFDLPRSKPWLTYQDWAMKYGKLIYMNVLGQSILVINDANAAVELLEKRCSIYSSRPQFRMAQLTGWHWHMALLPYGKRWRDLRRVFWQYFRPDVLSKYREDQEAGAHILLRKLLASPEKLTEHLHYSVGAAILRIVYGLDVAEDKDRNIALAHKALSGVEFHIAGSFVLEYFPILARVPRWLPGTALLCRLDSIRQAVLQFRDEPWSYVQEMKATDTLRRCIAWDMMEQMPGSSGEFGASLSDSTARSAAGVAYAAGIDTLYATLQRLFVAMTLHPEVQKKAQAELDAAVGPSRLPIFGDRSALPYVNAIVKECFRWNATLPLGVAHATLADDTYEGYHIPKQTTVFVNAWAILNNPEEYPVPDNFVPDRFLRDGKPNLSIRDPATVAFGFGRRICPGRYFADETMFIFVASVLHTFNISPALDDKGQSIQVRPLLTTSLTAYLEDCRCMIRPRSIQAETLIVRTADRQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q540</accession>
    <name>A0A4Q9Q540_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_919291</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145094">
        <property type="protein sequence ID" value="TBU62375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q540"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q540"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990444">
        <property type="term" value="F:F-box domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0062026">
        <property type="term" value="P:negative regulation of SCF-dependent proteasomal ubiquitin-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070372">
        <property type="term" value="P:regulation of ERK1 and ERK2 cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14522">
        <property type="entry name" value="DSP_STYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000036">
        <property type="entry name" value="Serine/threonine/tyrosine-interacting protein a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052449">
        <property type="entry name" value="STYX-Interacting_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588">
        <property type="entry name" value="SERINE/THREONINE/TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46588:SF1">
        <property type="entry name" value="SERINE_THREONINE_TYROSINE-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU62375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="227" mass="26315" checksum="6506FD089F0AC07E" modified="2019-07-31" version="1">MNAAEFNQDQLRELIQGPSDVEWTYEMRRQCQEILPHLFLGPLQASKSLDTLKSFGITHIVCIRDAKEAFSVRPRFPEHFQYMVLDVQDSEEQNLIRLFPQAKQFIDEAISKGGSVLVHCNGGISLSPSFVVMYVMQYYNLSWEDALHLVQNRRYCISPNGGFMTQIKEYESIYKAKVAIASHPQQRVFSVRRKRSEEDDEDNIQRDGERTKRALVDEDDDDDAMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5B0</accession>
    <name>A0A4Q9Q5B0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Alkaline phytoceramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_810855</name>
        <name evidence="10" type="ORF">BD311DRAFT_660251</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143410">
        <property type="protein sequence ID" value="TBU29845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5B0"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5B0"/>
    <dbReference type="OrthoDB" id="187171at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046514">
        <property type="term" value="P:ceramide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46187:SF3">
        <property type="entry name" value="ALKALINE CERAMIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU29845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU62593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="288" mass="32391" checksum="3E99922A080C4AD1" modified="2019-07-31" version="1">MALNTTTNALLAGQAFWGPVTATLDWCEVNYQFSRYIAEVANSFSNLFTIGLAVYGAAQSVTEKLPPRYLVGYAGFALVGIGSFMFHATLLFEAQLMDELPMIYVASYCCAVLFDTSRGFDLRQSNAGQLGVIFMVFNVLFTWSYYTNRNPIYHQAVFAVLMLTTTFRTAYLLRHGEISKRLHQAQRSTIARMFGSGAATFAFGFLIWNLDNVFCSHITRWKQSVGWPAAFLLEGHSWWHVLTAIGTYLMLIGNTYLTLCIKDDPNNYTVTKVHGLPRIQRTDGAKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5B2</accession>
    <name>A0A4Q9Q5B2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Rsm22-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BD310DRAFT_919637</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5B2"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5B2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="554"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU62116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="643" mass="71722" checksum="71257097DC18DCEC" modified="2019-07-31" version="1">MLRLGCRRVINTGWRRQAELVRYASGSSPSHQPNAPLELDPAFQALLRDVEMSLRSKAPHDTSGSHGPRELELFPRDPHTTVDYLTSAELDAQDESSNRGEGRKSPAAAFGSQRIGAVVLPFEMQSAISRLVADSDKPTLRQDAKRLFSNETVTGEEWNSTFDMRYNSAKEAGRHALRDATAFATVALPSHYSVIYAVLDHIKRRIGPDWQVDRVIDWGAATGSGLWASGHVFQRRPDADGRNAQDVEDIRISQTSLSSYLGIDKREGLVRIGKRIIRDLDMGSLHAAWQKSFHDDDAVDPVESSSAVALSAFLLSSLPTPVDRKIMIKEMWESGAEVIVLIDHSFENIAEAREQFLKLGKKEVEDPTVAGSSPRGAHVVAPCPHDGACPLYHPGYGKLQCTFSQRMQRPEFVRKTKHSGTGHENMDYSYVVIRRGPRPAQTSAKAGRAGDIGLRELAKRAADSVPMNRLSLASDLHDETELSHKEESSRILESSEASNESHELASAEVSAEVTSALRQEAYSWPRLIFPPIKRSGHVILDVCHPQGQIMRMTIPKSQGKQPYYDARKSSWGDIFPHEPKNPPQLRRQPAHPGDTPSQGQDIGKRRHHKADFKKASYAKLAEDIKERRRDQRRARRIAESYDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5D5</accession>
    <name>A0A4Q9Q5D5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PhoX domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_974360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5D5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q5D5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06876">
        <property type="entry name" value="PX_MDM1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF3">
        <property type="entry name" value="SORTING NEXIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="7">
        <location>
            <begin position="107"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="5">
        <location>
            <begin position="437"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="863"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="591"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="722"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="746"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="827"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="643"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="726"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="751"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="761"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1230" mass="137230" checksum="55355C07E5220E29" modified="2019-07-31" version="1">MPYGRHVVALLIVGGLVVPIFKRIILSPVALALLSPFFLLSLVLGFLTVNLLFGYLLDSIRPAPRNALTTAARPLAFSTPAAWQAVLTRSQWSHKAPQSLPPLYPDAPVVSAAINEILIMIVRDFVLVWYKDISTSPSFPTAVSSTLHSSMDRLLAKVLTLDLSALVVKRILPKITAHIEQFRQSEIALRGAGLERKLTQSEELDLLLASRYAARGGGKLHSAVENLSSTFTKQSEENHLRELVDKALPSILPEKEANSRAVKIVVREIVACSVLYPVMEMLSEPDFWNRMIDQVAGAAIRQQRLISKVRNILEAQIPRPQAPLSDAPQSTTEKITIRTDPKHFESFLRSISRTSSLLDARRLRNDIMGEIRRTRTLLANNANSDWINGEKTEDIVAFLDRLYTAKRKVEKRIAALGGEADSRQTIYQETSTTSKLTLRDTLMNPSSLSYFMEFMDRRQRSLLVQFWLTVESFKNPLESVDSDGSDDEDEPLLDPSQSATLKEDISLINELYFSSPVPDPVLSAVSKKHVDTIRSFGQDAASLTPASERRVRRSVMLAQRQVEREMEQDFEDFQRSELWFRVLADIEANGGRGALADDGPLHPRSRSPTSTRRDTEGVPAAKLGPKPGLPRSESTPILGFPGRQPPTPHTPTPPPQPRPAASNLQVLMSPVDELDSSAAASRAPLFDDPEDTEQQIQAQRMDAIQAALTDIIALDKQHAAAGASADSLSVQDSVLSGGTRTGREKRRLVFDDDVEEDEVEGDRSREEEAEEHDKDEHGSFQLAGPGDLQLSHEIERLAGKIAKLQTQDGMLDTLIKKAELTGDAQELRLMRRSKAQLTRELRELRFQKTQYEQQESANRLLSDRTRVAIVNSTVGEEDGKQVVRYLVEVQQLAQDGSFASGWVVARRYNEFFNMHNKLRDKYVLVRNLDFPGKRLVTSLSGSFVDSRRISLEKYLQSLIAIPAVCESQELRAFLSRDSPFMAAEPPPPKPSSSAFPGHGLVKTMYQSVAESIDDMFFGPSMLDVIIQRLTTQAAEFVGITGTAIRDEDLVAQALKASGKSTYEDALMHLSGDLKPLEGETSTSTFSSPICDFILAVFELDKKNNWLRRQAIVIILQQVLGDTIERKLRETVRSFLDEPHLMTYINVFKDGLWPGGNLKPPSVPRTVEEKLHTRDEANRKLSALMPDLAANMIGRSNARRGARRIFAVLQNRRLNQHLIYTIVDEVFAALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5F7</accession>
    <name>A0A4Q9Q5F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_55383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5F7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="171" mass="19763" checksum="32587AE21814910F" modified="2019-07-31" version="1">MPLSNIRRISDSHLSSAIADRREDITWHTHLFISILEQVWGADTSRDGARVSRSGTTTPPICFESCDHSQDHLHKHRTYRSRHVTLSVSFLLENIRRLTDRASHRILFRVCARRRQLYVVGAPQRGVEAQTSLFAWPLTHQRRVCNVLIRFPVVALWPVERVSREPPAQSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q5Z5</accession>
    <name>A0A4Q9Q5Z5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_974255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q5Z5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020644465" evidence="3">
        <location>
            <begin position="21"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
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        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU62451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="385" mass="41670" checksum="9BAD782FF15644EE" modified="2019-07-31" version="1">MAPHVWISCLVGLLAPCVLASVRNRTIDDADRSITYSPQWKTACDYPYPWSQCPDPIKIKNGTLHWVWVGQTPDQSDPPQISVQFTGTAVYVYNVLPYNPSPQPDIQFILDNNTVSNYTQPATSSWGYTYNSLVYANSGLQNVPHSLVIEAKGLSLVMFDYFEYTADDDTSSPPPPSLPSSSSSSHKSLSSITSISSQPQSEPGGSLSLDSGTPMSSASRVPTVPGSPPTASGAHGSARPESIAGEVLGSVLALAVLTGAALYINRHLRRRANKKALRRLADDDGLPRMIDSSGHVCQEVPIICAPRFPIRPTPDVPHSRRPTMSSVATSPTSYNNVAPSKTYLNDGIMVSILEKVEVSRSEYPTFTPIERGLEKDGSQVRPKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q6S8</accession>
    <name>A0A4Q9Q6S8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_903867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q6S8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="181" mass="19594" checksum="6F5BFE7347268520" modified="2019-07-31" version="1">MWLDNKRSQRITNLTLGMVVWRHHEGPQGMNRMSSSFKLASSRIASGNKLFAVSMNDWIASQSASDGELRAPESYCSRVYAPVEMNKKTLGPGAGFSVVIHCAQEGVDICWRKLEGKYSLCGISSAILISAGAALRTMLKSCWYDITNDTSRSEARTCGSTSRSISPKVASSAMAIDSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7P1</accession>
    <name>A0A4Q9Q7P1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_663588</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145091">
        <property type="protein sequence ID" value="TBU63001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7P1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="161" mass="17487" checksum="9A88115528127A20" modified="2019-07-31" version="1">MCTVSSFLPTVLYSYAFFHDLRHGLQSWLFVPPPALSCICDSLSLSLVYVYPSPSIIPLSPPPHKFTRALLRSLSNCSVITTRSSTTAPHGRLAHKAPAIVILPFPCVPGSWDVRLCRTGRQVRPVTSTVCLVHPALVVLHPPCPVLALRNIRASVAGPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7U0</accession>
    <name>A0A4Q9Q7U0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peroxidase</fullName>
            <ecNumber evidence="15">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_808562</name>
        <name evidence="17" type="ORF">BD311DRAFT_677034</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
            <strain evidence="17">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12 15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="12 15">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="12">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 15">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="15"/>
    <dbReference type="EMBL" id="ML143562">
        <property type="protein sequence ID" value="TBU22010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7U0"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00692">
        <property type="entry name" value="ligninase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024589">
        <property type="entry name" value="Ligninase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11895">
        <property type="entry name" value="Peroxidase_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 12" id="KW-0349">Heme</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="4 12 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 15 18" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5041003634" description="Peroxidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="69"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="13">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="39"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="61"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="290"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU22010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU63603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="377" mass="39754" checksum="FC2A6C2AD5C33648" modified="2019-07-31" version="1">MLFKAFLLVVSLALAVTAVPPHVKRAACSNGRSANDARCCVWFDVLDDIQADEGLFEGGQCVEEAHESLRLTFHDAIAFSPTQGYVSELTILFVPYLLIVIVGHSGGGADGSIIAHSDEELKDPANNGVDEIIEKLRPLAIKHNVSFGDFIQFAGAVGVSNCMGGPRLQFLAGRSNDSTAAPAGLVPKPEDPIDQILDRMADAGFSANELVDLLASHSVAAQDTIDPTIQGHPFDSTPSTFDSQFFVETLLKGTSFPGNGSNVGEAESPYPGEFRLLSDQVIARDSRTACEWQSFITDHDAMVSKFTAAMAKMAVLGQDVNSLVDCSEVIPTPATLATKVAVIPAGLSLDDIEASCSETPFPTISVAPGAETSVAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8T9</accession>
    <name>A0A4Q9Q8T9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clp1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1035678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8T9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU63451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="33748" checksum="B7F76931381988B5" modified="2019-07-31" version="1">MFHVASRHAAPEALNLSSAQYSYPVEHKLNIPRRLARPSFTEPARDAVARLDPGLASVPLEYIKKMLAGNANETLTALSLLTIPSSLPCAHLPSSIDAPIRPSSNTPDASAFPTHVFAILSSRSSATTPTMATFADRSSLSPSTTVPLFPASALVMAVHCSLLPPLPQTHRSAGRRAALTLPIVPLTVPSPETYALLHAYLHTMRPDTLLASLLPSLASSLPQVSISGSSMGSNKLVYVAQFSSDRLVRLASALAGAAFQRGGSTQAALSGLMAHIKVINGLWQNVCALGVFDAELWGVMDLAWDVVLAAMTKVMENKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8U4</accession>
    <name>A0A4Q9Q8U4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_461454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q8U4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25258" checksum="A239D53A60CD8AF6" modified="2019-07-31" version="1">MRPRPISPGEPLSLVNDLWRRISAFPHVGRTCFLAVRYRHLSPRSPRVQNTLPYIHASATLMLFHVAVLSIVSFWFLHHVCSAALITNAQKHTENPENPTHRASLVQSFRTFAFVVPFHTHNPPPSPATKPPCFLPPFVRFTPVACFIPVGSLCDTIPLMFPTSESQVTLLICTCHQLETALCSLPPSHPSISAANAATQKPLLPYRGILKNGATGSRICSNAGVRMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAL1</accession>
    <name>A0A4Q9QAL1_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_915426</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAL1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAL1"/>
    <dbReference type="OMA" id="SQTRCVG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd12098">
        <property type="entry name" value="DD_R_ScPKA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003117">
        <property type="entry name" value="cAMP_dep_PK_reg_su_I/II_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02197">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00394">
        <property type="entry name" value="RIIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU64136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="491" mass="53986" checksum="41365715194AC5D9" modified="2019-07-31" version="1">MSDMSTFDLLVSELTRDAQRVQPKDALQFCAKWFQSRLEEQRARTRDALARHPSFAVALPQDHYMDTLLSPTAGSPGGPTSISPFSHSFPQQRSSLQNSMSNNSPFGTLNVPGNALLDNGSRTLTPVSPPSFQLEGEDITPATPISNPNPFASFANGSISPSPGEFLHPPTATILARRTSVSAESIPVDSETHEPLPVFPKTEDQLQRIRASIAANFIFRDLDEEQETGVLNAMQECKVVTDDVVIRQGDVGDYFYVVESGLLHCYIRPEPLPSNWFTGNVPASDKFNQSGYHPVFGRKVAECREGSSFGELALMYGHPRAATVLAIEPCTLWSLDRITFRTIILKAAHRRRTMYEQFLSSVDLLASLEPEERSKVADALVSRVYEDGEAVVRQGEMGDTFFFVEEGNAVVTKVRNGGPEVVGHLKKGDYFGELSLLRLEPRAATVSAVVRADPGAPRLKVAALDAHAFTRLLGPLREIMERNAGRSYGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBJ6</accession>
    <name>A0A4Q9QBJ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein bL34m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_398552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBJ6"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBJ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.3980:FF:000001">
        <property type="entry name" value="Mitochondrial ribosomal protein L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_bL34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_bL34"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL34M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN 34 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="127" mass="14137" checksum="56BE92E27B376357" modified="2019-07-31" version="1">MPRIPPSLARLLSRPPTLPTAVPRAATSVSFASSLTPFKPILPSASPTSSLLRSLPTLLTRLNLIPATLSPIFSPLLQVRHNTKGQEYQPSQRKRKRKHGFLSRKVTVNGRKMLARRRAKGRLFLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBM6</accession>
    <name>A0A4Q9QBM6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_944042</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <source>
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        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="281" mass="32045" checksum="E655F4FBD930EA28" modified="2019-07-31" version="1">MSLRVASFLSTALRPRLVRPPLSYTFPRTMTSRAVEASRAVLKSIDLSAGYDAEQTRLMEERCILVDEEDNALGAADKKTCHLMENINKGLLHRAFSAFVFRPSDGKLLLQQRATEKITFPDMWTNTCCSHPLDDFEEEKEEKDQRGVRVAASRKLEHELGIPRSQTPVDEFQYLTRIHYLAPSNGLWGEHEVDYILFLTADVTVTPNLNEIRDHKYVDKAELQAMFEDPANSFTPWFKLIARDFLFGWWDELLARKTADGQVYAKSLAGLVDGSKVVKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBT1</accession>
    <name>A0A4Q9QBT1_9APHY</name>
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                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="7 8">CBS 464.89</strain>
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            <begin position="20"/>
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        </location>
    </feature>
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        </location>
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    </evidence>
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        </source>
    </evidence>
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    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="199" mass="21846" checksum="A388DE3733B6E9B9" modified="2019-07-31" version="1">MSMSNSNNIRSHFASFAAYTPPPDDPSYPGSTSRGSSRAWFPSGAASGSQQPTSYQSGGIPTFNTSQAGGAGALEDAEAENVNNLWETRHGLRVDLLAASAYLLGPVSALTLLIVETYNDFVRFHAYQSALLTTPLVIMRILASLLQFSSFLRAIFTFLLIIPSYYMAWRAYVDASRNGLVRFQVPFIGPLAERWVYEE</sequence>
</entry>
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    <name>A0A4Q9QC44_9APHY</name>
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        <submittedName>
            <fullName evidence="6">Bromodomain-containing protein</fullName>
        </submittedName>
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        <name evidence="6" type="ORF">BD310DRAFT_1001754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
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    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00439">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="262"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="465"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="644"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
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            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
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            <end position="798"/>
        </location>
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        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
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            <end position="114"/>
        </location>
    </feature>
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        <location>
            <begin position="137"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
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        </location>
    </feature>
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            <end position="759"/>
        </location>
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        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
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    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU64860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="798" mass="86988" checksum="352EE816DEF57578" modified="2019-07-31" version="1">MHDALSSALNGAHTDSVSAPDSPAVDSVATPINNSLVPDVKIDVDYTEQESDARHEPAPLKLDKLENASIVPQLGTPVDPGTCIARFDASSSPDARQDTIPIAPPHGTPPPPPGELLDDVKMAEQNPPVPGGDVEMSESSGKVNGLPNGQTHESPVATPVSPSVPAVTSSSETAVDSHLASSPYANNTNANEDDDHDNKPPPAKRARKYSDAERASLANTGTPPPASVSPPPTAYPPAEPAGPSTLSVAQWRFSSSTVRTLKKMKDAGPFLNPVDPVALGIPHYPQVIKRPMDFSTIERKLAASNPAKPDPNPSNPRYHHAEQFVQDVRLIFTNCVTFNGPDHPVTQMGKRVEAVFDKQIKQMPPPEEPKAPTPKKVASPPPPPAPVKKQARRPSAPVAPVIRRNEEAVVSAGRPKREIHPPPPKDLPYADAPRKSRKTKGPKNAIVAEQMKFCEKILKDLHQKQHYQIAHPFYEPVDPIKMGIPEYPKIVKKPMDLSTMKRKLDTGDYPTPEKFRDDFRLMVKNCMTFNPPGNPVHEAGKSLQNLFDEKWKNLPIPRSHDLSDDEDEEDEYESDDERARMEGMIADMESQIASMKNNLAALKRNGKEKEKKKEKREKPTPPVASTSKSAPKHSKAPLQKSKKGKKPVTDDDVLTFEQKKDLSDTISKLDGAKLEKVIQIIHDGVPEIRDSTEEIELEIDQLPAAVLTKLYNFVIRPMKPPVKRPRTGKGTGTGGLKRKSMDEDVETKKIRALEEKLKSFEQGGRTSGGTTNGAAAGDMSEHSSAESSSDESSASDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QDB7</accession>
    <name>A0A4Q9QDB7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_306109</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU65206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QDB7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="240" mass="25972" checksum="F468D11B180912A3" modified="2019-07-31" version="1">MPGSSPPPMTNRSQAAPPNRRTSLNRNDDSPYPRTARAVQPNPLQPQHPDAPHRLPFSWSSSLLTMLTVIGCFVVLCSYASSASTLFALYAAQPVYALYPTLVAAMLVGGCSALICYFPTMLAVFTFQLLFDTDIRKTHTPPPGSALAHAQAPAAREMGWSLIRDGATTIKLALLVAPVYVMAVGRVGSVAVESRALDAAAGGQLAAAIMTLKIMTVGMREIWDLVPLVIFRWHRDVRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEA4</accession>
    <name>A0A4Q9QEA4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_837582</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEA4"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEA4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU66079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="554" mass="59657" checksum="2A7B2839709363C7" modified="2019-07-31" version="1">MFQRDPRAGAFLGGDRVSGQDVRDQNVLAAQTIANIVKSSLGPMGLDKMLVDNIGEVTISNDGATILSLLAVEHPAGRVFVDLAQKQDKEVGDGTTSVVLIAAELLRRANELVKQKIHPTTIITGYRLACREACKFMQDQLSVKVDALGREALVNAAKTSMSSKIIGSDDDLFAPMAVDAMLSVKTINNRGDIKYPVKAVNVLKAHGRSARESLFVKGYALNCTVASQAMKKRITGAKIACLDINLQKARMQLGVQILVDDPSQLEDIRKRESDITIERIRKILAAGANVVLTTKGIDDMCLKEFVEAGAIAVRRCRKEDLRRIAKATGGTLVSSLANLEGEESFEPSYLGYADEVVQERISDDELILIKGTKVVSSSSIVLRGANDYMLDEMERALHDTLSIIKRTLESGSVVPGGGAVESALSIYLENFATTVGSREQLAIGEFASSLLVIPKILAVNAAKDSTDLVAKLRSYHNAAQQAPIGDPKKVLLRYGLDLLNGEVRDNVAAGVLEPTVSKVRSLKSAFEAAISILRIDDAIQCIPESKPEGDGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QFG3</accession>
    <name>A0A4Q9QFG3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCR4-Not complex component Not1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_954066</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QFG3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QFG3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="3">
        <location>
            <begin position="133"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU66036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="176" mass="19780" checksum="C88A618FAA30ED3F" modified="2019-07-31" version="1">MRRRFHSLPSSSIQVLPGVRSCFSMRSDGAPNMQPITPACLDAVDTGESSTPLDASQVPPTTAQLTTTKKPRAPRKTPQWPPPADLRGANWAEFEQHYKSMTPFDRRQSDPYDLLYAAFPPHQFQSMTLRLVLVLLLQPTYLPGFVFSWMSLISHRLFMPKLLPSKNREVGSGPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QGK5</accession>
    <name>A0A4Q9QGK5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_40536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU66074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QGK5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU66074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="182" mass="20338" checksum="3353391154E02B80" modified="2019-07-31" version="1">MMPSANNACRSPSLRRERASAGLDQRRRAGIQTFAPTPWSFEICGSSDRHDRHMRTLALGCATADSLVHVCTNVRTMCACCDVVLRRRRNPPSRSVSGTFLWLDATSIATVRSAGTPFVLHERRACLTMACFASDNYGERPYAHTQQDKRTPRMLLNTDGKFLPNPTGMSYNERSDVLVQQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2JZ38</accession>
    <name>A0A4V2JZ38_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_950173</name>
        <name evidence="3" type="ORF">BD311DRAFT_817854</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143500">
        <property type="protein sequence ID" value="TBU23593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145153">
        <property type="protein sequence ID" value="TBU56307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2JZ38"/>
    <dbReference type="OrthoDB" id="2803865at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU23593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU56307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="316" mass="34770" checksum="36ADA51D783748BD" modified="2019-07-31" version="1">MLLLNYLAFAAFTTLRVYAVWGRDWKPLLLVVPLTLAKPALQIYEITHYNPVQAGAPFGCVLDWTMSNALLTKFTIIGQATTIAAEAILIGLTWMKTFGINLDSLRLGVRTPLATLLLRDGTAYFIIIFLLEIVTLVSSNIGSQLTVWMVWPYFAQVFTVIFLSRFMLDLRGLYFADRAPRVHGGPSAPAGAESTFSVKMSDIRFDTSRIVGNMGATLSHPDHTSSIYSDASGFASTHDVESRAAHVDGIKEVKRSGEGDGWYEDEKPIFVSDPFREGLRPPVMVDIELEAPISPLSPASYQDGSQASSSQIFSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K291</accession>
    <name>A0A4V2K291_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_911625</name>
        <name evidence="12" type="ORF">BD311DRAFT_744500</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143386">
        <property type="protein sequence ID" value="TBU35733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K291"/>
    <dbReference type="STRING" id="114155.A0A4V2K291"/>
    <dbReference type="OMA" id="NRRMYRG"/>
    <dbReference type="OrthoDB" id="2382881at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF9">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="230"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU35733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU65579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="338" mass="37804" checksum="FF6B30CEE5A064DE" modified="2019-07-31" version="1">MSERRPGKYLFDSAALNESLKSNKAVVCALSASYISTFAGYPLDSIKSRLQTTKQRVSIPRLALTVYQEEGIVGFYRGIWIPLITISFVRAASFTIYSRTKEYFRDRHWLSRNRIFDVSAVGGISGALSGSLISFASAPFELVKVRRQLEYSIASSKGIRLEKAPKTLEAVRDIFRSSGILGLYTGFRLHFLRDTLGTALYFFEYDGFRYIMGRHASGEQGQTPLWLPIPASVVPFFCGSLAGVTSWALIYPLDVVKTKVQQRALAGERKRGVVETFRRLIRGPDPDHPKPLLKGIARLYQGLGVSALRSVTTHGLLWTFFDLTASYIDRLPGPANRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K5I4</accession>
    <name>A0A4V2K5I4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_1038970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K5I4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU58776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="190" mass="21409" checksum="485368E58B593936" modified="2019-07-31" version="1">MSSVAANPLRTSLRRAAVCSRYSSTQASPPHSPSSSSQTKLSVQPKAELPPEKMRALVDLYHQSATFITPANLSDKIDEAFIYRTTNKSRLNPEKPLSKILYDLKVRRAFPKFGEKLGPTVKRTRSPAVLKYEDWSEERSPREQQVFRTLHGVYNRAKPGYDALMDEQASAEKGEEDEQQQETQGEQGPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K784</accession>
    <name>A0A4V2K784_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_934293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K784"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU55138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="179" mass="20224" checksum="270D94BAD745F1A2" modified="2019-07-31" version="1">MLRVLCTMQHSHKSKKTQEKDLVGSVSRSTTASTPFGTTTPTTAPMAWAVVLRALPKPRALHVRRLAHARRELARRRRARPAQPRRRGVRARDVRRVARPGCDRVLMMGPGRGAATSESVSMTEGTRFTDSRYFPAKTGGWQSLRSASQRWEVGVCCLQDHLLREAMLSFNFRAMTSHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7R3</accession>
    <name>A0A4V2K7R3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_853705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7R3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="23"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU57128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="322" mass="35600" checksum="0B44278811C2CE77" modified="2019-07-31" version="1">MSADSETQAAIAEARSLFIGNCYGLAVLALFVYDYLITLGSEVTLFWMPREVNGASILFLLTRYITLATEILNVAPFPASFHGTVVMIMAAVVIRSLQYLPWAAFSALRVYALCPGPYRFLIAAIVLPLSLVPLLINMLVNLHWVHYLDDPQGGVIVVDMLSPSVNLKFIIASRASLVLADLLVLCVTWYQTYETVKVSRRDLADLAKPTFASTLLRDGTIYFLTLLMLNVLHMIFSLTSIGSNNVFDLASVIPYFEEPLTSILTSRFLVNLQQVKHRLAGSSRSLSQMSEPAFQPQASRNMNGFIGSLGAQLSFDEEESDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8H6</accession>
    <name>A0A4V2K8H6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_354772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU59968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8H6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27911" checksum="4A18290D802C8CE8" modified="2019-07-31" version="1">MSRCKLPVERCEQIVDLCNFPHREFVNKPATRRPSTYATLRACALTCKAWYPRSRLNLLRIVELSTERQVDLLIRTLTAQPFLADLVIELEHYRPPGSLNNYVPLSRSPLPQILQNCRSLVFPLLKSHHITYTRSLPFFAHITRLEIAIDGHTISTLLHLIWSFPDIQHLLLKWSYSREYSTAVSEIYRRKLGEMRPPSCCKYLEYLNACSLRQSLGTLSPILRFRVKSTIAIPRLTAGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8W5</accession>
    <name>A0A4V2K8W5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="3">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_920278</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="3"/>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8W5"/>
    <dbReference type="STRING" id="114155.A0A4V2K8W5"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PurM-like C-terminal" evidence="16">
        <location>
            <begin position="203"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="17">
        <location>
            <begin position="429"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="16">
        <location>
            <begin position="624"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU61568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1091" mass="116887" checksum="E71D7777F5D96575" modified="2019-07-31" version="1">MIRNTEKLNGTGTISAYSDNAAVFEGHNAPRFAVSPNATSKANPDVKDLYHGEEEDMPILIKVETHNHPTAVSPYPGAATGSGGEIRDEGAVGRGSKPKAGLAGFTVSNLLIPGYEQPWESDFGRPGHIASALDIMIEGPLGASAFNNEFGRPALAGYFRTFSETVSLPEGTQEVRGYHKPIMIAGGLGNVRPAFARKSKISPGAKIIVLGGPGLLIGLGGGAASSQVSGAGSADLDFASVQRDNAEMQRRCQQVIDACVALGDANPIQSIHDVGAGGLSNALPELVHDSDLGATFEIRDVLVADSSMSPMEIWCNESQERYVLAISPEQEAQFRTLAERERCPFSVVGIANDSDELVVTDRLLQQDVIRLKMSTLFGQPPRMHRTDTHVAPPAVPFKTDLAEYLPNTQAPERIAEAVSRVLRLPSVGSKSFLITIGDRSITGLVTRDQMVGPWQVPVADVAVTRSSYGFDVRTGEAMAMGERTPVAILSAAASARMAVAESLTNLAAAHVGELGRVKLSANWMCAASKAGEGAALYDAVKAVGLELCPALGVGIPVGKDSMSMSMKWQDAKTQEGREISAPLSLIVTAFAAVEDVGKTWTPQLRTDVGETTLLFFDLARGRQRLGGSAIAQVFKQVGSEAPDVVDPQDVKTFFEASQVMRTAHPGLILAYHDRSDGGLFTTLVEMAFAGRTGLQINLESISSKTDHVSALFNEELGAVVQVRESDIQHVVDFFTKRGFPSDSIHQLGSVTADETIRFSSASGEVFTSTRAALQEAWAETSYRMQSLRDHPQSAKEEFDLIKSSNHRGLFYDLTFTYSPSRSLFRRPKVAVLREQGVNGQVEMAWAFTAAGFDAVDVHMSDILSGAVSLSTFRGFAACGGFSYGDVLGAGKGWANSVLLNATARSEFEAFFTREDTFALGVCNGCQFMSNLREIIPGTEHWPDFKPNRSERFEARVSVVEVVPGDATSRSVFLREMAGSKLPVAVAHGEGRAAFSSPGQQAQLEAQSLVGLRYVDSSGAPTEAYPLNPNGSPGGVTGVQTPDGRVLALMPHPERVVALESNSWYPPEFVETWQGTGPWFKLFQSARKWCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V6MWM9</accession>
    <name>A0A4V6MWM9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_158785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145215">
        <property type="protein sequence ID" value="TBU53403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V6MWM9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="205"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="442" mass="50880" checksum="773F92DF91645353" modified="2019-07-31" version="1">MNSPGQNTVACHLDHALFLPLVTNHSCYAATHPPLPSREEREALFAKCFAQLRDETYATGWFYFADSKLIRRENLLDWLSWAFFGTHPDGLHEEWAEEIEGYLRNIEQLLGHKIEDGRDHTVRAIKVSLDPVVTAYRPLLWYLTVAFIDTITTIQLYFKGFRHYTYGSWMCCFPPRPLTAFSNKSTHDGLIYWLRPHRSTTKDPILLLHGIGIGLWPYVPFLQELADADPDVGILATECLAISMHISAPPLSRPEMLAALTALLDAHSVSRVVVAAHSYGTVHAAHMLRDPTLSARVSAWLFIDPIPFLLHQPSVAYNFVYRQPRTANEWQLWYFASRDPDIARTLARHFFWAENILWKEDIEGRSVAVVLSELDQIVDAKEVRQYLTDEVTDEPKFRWQKEGLEVLWYRGIDHAQVFDTKTRRGPLVSILQSFAERKRPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MAT4</accession>
    <name>A0A4Q9MAT4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleic acid-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_940201</name>
        <name evidence="4" type="ORF">BD311DRAFT_868248</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143484">
        <property type="protein sequence ID" value="TBU24219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145249">
        <property type="protein sequence ID" value="TBU52484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MAT4"/>
    <dbReference type="STRING" id="114155.A0A4Q9MAT4"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US17M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU24219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="110" mass="12349" checksum="5BDF14D13B3C8BEF" modified="2019-07-31" version="1">MPPMSFIGQVTKVGYMSKTATVTVSRFITHAKTGKRLERSKKYLTHDETSQLRLNDTVLIRNCPPISARKRFTLEKVLKSPERAREELHARQAAEAAVRLQAEPNATATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MEJ8</accession>
    <name>A0A4Q9MEJ8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_949292</name>
        <name evidence="1" type="ORF">BD311DRAFT_790180</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143455">
        <property type="protein sequence ID" value="TBU25790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145135">
        <property type="protein sequence ID" value="TBU57562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MEJ8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU25790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10029" checksum="9D0C7ED19424D78C" modified="2019-07-31" version="1">MGLAMATIPKDGSNRRPRVSIKAYHWAGLTSSPWGNEEDTSITNQAYWCPMRNSLFWADAGNPEAVTGLSTHLSRAATNRSATFHDEPHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MIP7</accession>
    <name>A0A4Q9MIP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_788464</name>
        <name evidence="2" type="ORF">BD311DRAFT_597465</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143451">
        <property type="protein sequence ID" value="TBU26052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145260">
        <property type="protein sequence ID" value="TBU52233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MIP7"/>
    <dbReference type="OrthoDB" id="2758403at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="2"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU26052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU52233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5648" checksum="7C3D574193F5B366" modified="2019-07-31" version="1" fragment="single">PTLPLELEHMIIGYLHADKSALKAASLVCKDWTCAARRHLFRSVSVIGVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MS88</accession>
    <name>A0A4Q9MS88_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_847380</name>
        <name evidence="1" type="ORF">BD311DRAFT_754367</name>
    </gene>
    <organism evidence="1">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
            <strain evidence="1">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143405">
        <property type="protein sequence ID" value="TBU30465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MS88"/>
    <dbReference type="OrthoDB" id="3793816at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU30465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="184" mass="20324" checksum="E57BF6EDA4B191A9" modified="2019-07-31" version="1">MLIFTSPDIVKGSFELAIARKSPGTYLVILARAYGMAATREYIVLNVSTPRSTVPPLSSAGRPLIWLDADLDRQPPHLRPPNGVLAALRAADSEVIRPTGRTQRMHAKLGGERDAHEVELLLDEDQLARSCWYCDALEVDTDVRDNDRFPLCSGEGYTSTYMCQQCAKKPAFARAISGFLHSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MT76</accession>
    <name>A0A4Q9MT76_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_951479</name>
        <name evidence="17" type="ORF">BD311DRAFT_738737</name>
    </gene>
    <organism evidence="17">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="17 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
            <strain evidence="17">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="ML143413">
        <property type="protein sequence ID" value="TBU29456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145190">
        <property type="protein sequence ID" value="TBU54360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MT76"/>
    <dbReference type="STRING" id="114155.A0A4Q9MT76"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="14">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="205"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="16">
        <location>
            <begin position="300"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="TBU29456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU54360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="566" mass="61600" checksum="F32754F6630CAB02" modified="2019-07-31" version="1">MSYQVKEIPTKPFEGQKPGTSGLRKRVKVFKQEHYTENFIQAIFDSVEPKGKTIVIGGDGRYFSPETVQTILKIGSANGVAKFIIGQNAILSTPAASNVIRKYKADGGILLTASHNPGGPDADFGIKYNMSNGGPAPESVTNTIYEKTKAISTYKVIELEPIDLSKKGFFTYGPTNVEIIDSVSDYLQLLESIFDFPLIKNFLQSHANDFKVLFDGMHGVTGPYGRAILVDTLGLPASSVQNATPLPDFGGGHPDPNLTYAHELVERVEKDNIQFGAASDGDGDRNMIYGKGAFVTPSDSVAIIADWAAEAIPYFKKGGVKGLARSMPTSAQIDYVAKKKGLECHVVPTGWKFFGNLMDAGRLSICGEESFGTGSDHIREKDGVWAIVAWLNIIAYANQQTPNELVGIKELLQKHYAVYGRSFFSRYDYEEVSSEGAQKLVDALNQHISAGSLADTTHKSKSTGQEFSIAGVSNFDYTDPIDHSVSKNQGQIISFSDGSRVVFRLSGTGSHGATVRMYVERYVSADKGPAELNKDTQEGLKGLIEVALEISKLKEFLDREKPTVIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N556</accession>
    <name>A0A4Q9N556_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Meiotic sister-chromatid recombination aldehyde dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_956612</name>
        <name evidence="7" type="ORF">BD311DRAFT_746070</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145095">
        <property type="protein sequence ID" value="TBU62172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N556"/>
    <dbReference type="STRING" id="114155.A0A4Q9N556"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07098">
        <property type="entry name" value="ALDH_F15-22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="90"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU34392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU62172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="621" mass="69173" checksum="EAE3F3853C9F9C86" modified="2019-07-31" version="1">MTHYHEVDYDYDDEGGLIDPAWLLAICFGLGIWLVINRYQSLLNRAIFFRIPPPPQIKETWTAQKLPEPGLEAHLNTDGLLPAIPLEGRKYITAYDPATAYHLDTVLADTPTEITKKIADAYEAQKEWANTSFHDRRRVMRSLKKWLVDNQETCAKVACRDTGKTMLDAALGEIITTCSKLDWLINHGERALAPQKRYNNLIMFYKSSYVHYEPLGVVSAIVSWNYPLHNAWSPIIAALFAGNSIVLKCSEHVIWSTTWFVKAIQECLKACGHDEQLVQLVCCYPEDAEALTKSPFIRHITFIGSERVGRIVAQAATEYLTPVTLELGGKDPAIILPSTDLEKHLSLLMRGVYQNAGQNCIGIERILVHESQYEDLFHLFTERADKLRPGHSLKSPGDGVAPVADVGAMISGERFPGLQHAIQEAVDQGATLTVGGEPWLHPYLERGSYFKPTVLGDVNPDAPIAQSELFAPIGLIIKYETVEQAIEIANGTRYGLGASVFGPVKDECLKVAKRLQCGMVAINDFGVFYLNQDLPFGGTKYSGYGRFGGPEGLRALTNTKAIVYDRWGWAIQTTIPAVLDYPVRSVTQSWDFISGLVAFLYADGWRQRIDALTKLIRASGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N5R6</accession>
    <name>A0A4Q9N5R6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_942872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145547">
        <property type="protein sequence ID" value="TBU50950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N5R6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="269" mass="29479" checksum="3B008FF3CE7B94AD" modified="2019-07-31" version="1">MGGFVYDGDQKKHMAYGWLDPRGQMAMDALVRVGMVYCRARKHAAFFRMLAKEGQRSRIIQVRDVARDQVIENRVVKVVTQLGAGMFKGDVTVEETFRHQLRGGKWTPELYLRITVSEKAAKLLTDDYGELKYGFNGKVESILILASPCCVGCKARGHFLSVCKLAHAFDLLNKLLPAAQAVGEGVNAGKGKQKEKSAPKAPKPSPPLATSKEDVMVDGSQPGEEDVAMGVAEDSEEEEDKSEGDASDESKSDTESNASEPANKRQRKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NB22</accession>
    <name>A0A4Q9NB22_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_771667</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145123">
        <property type="protein sequence ID" value="TBU58562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NB22"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU58562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="483" mass="54246" checksum="2903B836C4744D3B" modified="2019-07-31" version="1" fragment="single">LPLPPGPTPLPLIGNFLDLPTRDMAKKFRLLSEKYGDITYLDSLRQPVIILGSHEIAVDLLERRSANYSDRRPATMAPAAGFEWSLTLQPYGLRWRRHRQAFHQFFNPAAVLKYAPAQRLEAHRLVCRLLRTPDKFLHHIRHLYGSAIMRVAYGIEVDEEDVDYLGLAREAMSVFSTVFVPGKYMADTFPILHLLPSWMPGATFKRSSPSWRKSVSGLVETPWKAAMRDIVAGTAHPSMASGIMGRVSQSHDHYADPSEQESVARSAAATAYAGGADTTVSAAQSFFLAMATHPDVQRRAQAELDSVIGPDRLPEIDDMDRLPYIHAIVKECIRWRPVVPLGVPHRSMQDDEYCGYFIPKGTIVFANIWAFTRDPNVYPNPEAFIPERFLKEGRLNPDVRDPATLVFGYGRRGCPGRHFAQSSLFMIVATVLHTLTISPPVDDQGRPCKVESRMREGLLSHPEPFECVIKPRFSHVEALIRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NBH4</accession>
    <name>A0A4Q9NBH4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta-hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_968277</name>
        <name evidence="3" type="ORF">BD311DRAFT_758961</name>
    </gene>
    <organism evidence="3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
            <strain evidence="3">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143424">
        <property type="protein sequence ID" value="TBU28180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145139">
        <property type="protein sequence ID" value="TBU57307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NBH4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NBH4"/>
    <dbReference type="OMA" id="QYWTSED"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="109"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU28180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="359" mass="39185" checksum="158D7602ADB7F873" modified="2019-07-31" version="1">MSSLLPSIEAFAKGTAATAAGLGTVGFGLLFFGQNYLIYPSSYPPGSRTEVPVPTDFGLPYRDLPLQTPDGVKLACFLLTQRKELPNIGSMPIESPEEESNEEFAARRPTILMFHGNGGNVGHRIPLAKVFFVRMRCNVLMVSYRGYGLSEGNPSEKGIRIDAQCALDHVLSHPFLSKTPIILYGQSIGGAVAIDLASRNPHAIRALVLENTFLSLPRLVPTALPVLGPFAFLCHQKWDSASKVPLIPAETPMLLLSGVRDEVVPREHMQGLWELVQKRIPGGQKAAAPTSVPYFAPEREENTDKDISKDESVQNPAASGHSRFVEFQRGTHNDTCVQHGYWSAILDFISSLKDVPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NDU1</accession>
    <name>A0A4Q9NDU1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_924829</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NDU1"/>
    <dbReference type="STRING" id="114155.A0A4Q9NDU1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU59505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="95" mass="10937" checksum="3A1C4322C639FB49" modified="2019-07-31" version="1">MTQKQLIKTVNDVWHPMYKISMLAHPEPSVELTGGTVYIDKEQDTEFIKLWSDVCLEIVRDRLSSSPETANGASGRKVFVHHRVFRRSPRRGHSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NE14</accession>
    <name>A0A4Q9NE14_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HbrB-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_826746</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NE14"/>
    <dbReference type="STRING" id="114155.A0A4Q9NE14"/>
    <dbReference type="OMA" id="TRIIELW"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="124" mass="13613" checksum="10DE8F374FCCCAAB" modified="2019-07-31" version="1">MAPASAPSINATLSGESPWASLHVLILPLFNREQLRVQIEDLNQLVKRHISTVVSMAPGKAVATLEHDTFELIATGMVTLNSKLSGVEDDKLVPRVVELWTFFWTQVLPYLEGVRAGNPFCPCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NJM4</accession>
    <name>A0A4Q9NJM4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_827339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145182">
        <property type="protein sequence ID" value="TBU54742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NJM4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NJM4"/>
    <dbReference type="OMA" id="ERMTARC"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032183">
        <property type="term" value="F:SUMO binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140082">
        <property type="term" value="F:SUMO-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049627">
        <property type="entry name" value="SLX8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094">
        <property type="entry name" value="ELFLESS, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47094:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="135" mass="14304" checksum="9B3F5CF15B8ECA9F" modified="2019-07-31" version="1">MSTRTESLAQAVDQGLLPSSPRQESIDTPTTLKANAQTSRLSDTVPIDEVEPLAAYTCPICFSPPTFATITPCGHVLCGECLFTAVKTTIQRGAYTLPPGERMTARCPVCRAPIPGWDGKGGGVIGLRPRAVFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLX4</accession>
    <name>A0A4Q9NLX4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_789760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145177">
        <property type="protein sequence ID" value="TBU54983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLX4"/>
    <dbReference type="STRING" id="114155.A0A4Q9NLX4"/>
    <dbReference type="OMA" id="CEGVIGL"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07653">
        <property type="entry name" value="SH3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SH3" evidence="1">
        <location>
            <begin position="21"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="91" mass="10053" checksum="2C46074C9CD66E40" modified="2019-07-31" version="1" fragment="single">MDASQLGRWTRFAAKGGIGKCTAIQDCVAERAEDLMFMKDDEITVLMQIPGQVDLYLGYCEGVVGNFRGEAVRFHGRLKKPVLTKRQSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NM40</accession>
    <name>A0A4Q9NM40_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Chitinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_947865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="ML145112">
        <property type="protein sequence ID" value="TBU59600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NM40"/>
    <dbReference type="OMA" id="MAFQFPN"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00598">
        <property type="entry name" value="GH18_chitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="322" mass="33480" checksum="355FA504BD55F678" modified="2019-07-31" version="1">MFSFSRMITSVSAALALASVSSVLAVPVPNQAAPLASRAVSIPSPAFVVYTDRFISADVLPPVDQIAGFNVVALSFLTLQGALDQAGAYAALAPDVKAAKKAEYANAGINLIVSAFGATDKPTSSGADPIGTANTFAQFVLTNQLDGIDVDYEDLDAMNKGDGAAEAWVTTFTSTLRQTLPQGQFILSHAPLAPWLSPNAQFAAGAYVTINKNVGSLIDFYNIQFYNQGLYLDCAGLITTAGAPFTGSALLEIPKNGFDLNKLVIGKPGGLSDATNGFIDPATLGTCIDQAHAAGWKGGVMAFQFPNANADWIRAAKGTSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NNH8</accession>
    <name>A0A4Q9NNH8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-related protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_882081</name>
        <name evidence="9" type="ORF">BD311DRAFT_702627</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML143486">
        <property type="protein sequence ID" value="TBU24143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145146">
        <property type="protein sequence ID" value="TBU56794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NNH8"/>
    <dbReference type="STRING" id="114155.A0A4Q9NNH8"/>
    <dbReference type="OMA" id="WEDMQHL"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000148">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU24143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="392" mass="44637" checksum="62990D54B682713B" modified="2019-07-31" version="1">MDPSVPLVVDNGTGFVKVGYAGSNFPEHVFPSIVGRPILRAEERVAGSAVIKDVMIGDEAAENRNYLQVTQPMEHGIIRNWEDMKLLWDYTFDEKLRVDTRGRKVLLTEPPMNPKANRQRMAQVMFEEYGFQGVYVAIQAVLTLYAQGLTTGVVVDSGDGVTHIVPVYDGFALPHLTRRLDIAGRDVTRYLIKLLLMRGYAFNRTADFETVREIKEKLCYVSYDLDLDTRLSEETTVLVETYTLPDGRVIKIGSERFEAPECMFQPHLVDVEQPGVAEMLFQTIQSAAVDIRTELYKHIVLSGGSSMYPGLPSRLEKEMKQLYLTRVLNGDPSRLNKFKIRIEDPPRRKHMVFLGGAVLADIMKQREEFWVTREEWFEQGVRALDKLGRGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NRB9</accession>
    <name>A0A4Q9NRB9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(9)-N1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA methyltransferase 10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1G9)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_917281</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="ML145090">
        <property type="protein sequence ID" value="TBU63351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NRB9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NRB9"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU63351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="405" mass="45045" checksum="11C8FC0EE5964C60" modified="2019-07-31" version="1">MLGDPPDNGPPSPLPDRTETATAPAYPAPDSKAEPTSTAATETAAQAKERLSKKAQKKLAKAEHIAERKKERRAAEKERKKEKRREHAQKRDAGELEPEERERKKQKTEQGPRTPFGARVVVDLGFDDRMTENEIKSLTGQLAYTYSVNKKAVHPFSSLLFTGIDGRTKARMDGMSDAAYKRWVGAEWWEESYERLWEGKSNSGEGTQEDKEDEATEAGGTEGKKGQKKRPRKQEPSRAEKATVVYLTADSEEELTELKEGETYIIGGIVDHNRYKNLCLEKSQTQGIRSARLPIGTYLAELRTRKVLTVNQTFEILVKWVETRNWEQALYSVIPKRKFKTEGRKRGGGGASSKDGDSVAEEEAKEGGGLRGGDGDLQVVDVADLEDEAEHEPGEPLGGTVLMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NT42</accession>
    <name>A0A4Q9NT42_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Spindle assembly checkpoint component MAD1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_1025839</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD1 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145157">
        <property type="protein sequence ID" value="TBU56111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NT42"/>
    <dbReference type="STRING" id="114155.A0A4Q9NT42"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008672">
        <property type="entry name" value="Mad1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168:SF0">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23168">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05557">
        <property type="entry name" value="MAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75704">
        <property type="entry name" value="Mitotic arrest deficient-like 1, Mad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="310"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="389"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="675" mass="77305" checksum="8B87CB359D82143C" modified="2019-07-31" version="1">MPDPQLSTSKRQQRTQAFSSHVTHASLERQLAAAQTTKLELESKLREKDLLIERLEGDRRWLAEREKEEREEKEREREEHLEDKVRTTQKADGELRSLRSQLMTLREQHVDLEEEHSNLSRSTSQTIAGQKAQIATLTRQVSLLENQMQAFQRLAEERARAFDELQAQFDDLNAAQDSVTLGAGQNEDWAVVREELHRQATYVRQLESANAKMGAELNILHERQTSVEVLKEQKRDLERRLRGADELREQVVKLEAELDAARKERQEWASSSAEPATPSKTPVSVTQSLSNLRLAHVRLMEEHGSNVALLRHREQELSGLQEREARAQETVKELRAEVRELKDRALRSEHKASLVEREVSFLQAMVASFNAEDAANGEVKSENDTSMPIQELEALIKDYKETISVLERELKDARANPVIAEDVEAKQRLLALLEQERALKEEAEKALREAETESEKQLEQIEELEQTLFELRGEIGAGRHLPPGVRVLSLHDNPAQQWEDLSKAAMDRLKNENEALLKRLKDLEENGVRGSGQDANVELVPRESYEAVNKEKEELEEELRQKEKRLLRLKQIFNAKSAEFREATASILGVKLTFCPNGQVRVTSHYDLNAVFVFQPTGAGEGMKMQLIGQGGGGPEDLPQLMRYWIEEEQCIPGFLASITLECYDKRKREQELQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NU53</accession>
    <name>A0A4Q9NU53_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="13" type="ORF">BD310DRAFT_915664</name>
        <name evidence="12" type="ORF">BD311DRAFT_861080</name>
    </gene>
    <organism evidence="12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
            <strain evidence="12">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NU53"/>
    <dbReference type="STRING" id="114155.A0A4Q9NU53"/>
    <dbReference type="OMA" id="YETTPQG"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU34629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU63656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="85" mass="9491" checksum="58BA815A055F9337" modified="2019-07-31" version="1">MASQILPLELIDRCIGSRIWVIMKNDREFTGTLLGFDDFVNMVLEDVTEYETTPQGKKKTTLNQTLLNGNNICMLIPGSSGPEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWG1</accession>
    <name>A0A4Q9NWG1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_337822</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWG1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="34248" checksum="C0410C845D5B978D" modified="2019-07-31" version="1">MSSTCTNMFPPKPEWSVDQIPDLSGKVIIVTGGNTGIGKETVKALLNHNAKVYIAGRNPQRVNEAIEDLKKETGKEALFLQVDLGDLTTIQPAVESFMSQEQRLDVLFNSAGVMYPPVEQVTKDGFDLQFGTNVIGHFLLTKLLLPRLIETAKSSPDGKARVINTSSMGHTFVSGIDFDAIRDGQKRLKAGTKKLYSLSKFGNVVFAHELHRRYADQGIVSVSLHPGNLQTDLQRHISKVEAILTKNLLYPAPMGALTQLYAGTTLEGANLGGKYLIPWARVGEARKETYNEETGRKLWEFLEDATRSFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NX78</accession>
    <name>A0A4Q9NX78_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_911138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NX78"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU65315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="527" mass="59680" checksum="751D130DBAD9FA09" modified="2019-07-31" version="1">MTLTDGDHPLGVTGPSSLIDLHSDIWIHVTTFLPTPALAALMQTSSHLVELAASALCTRTKDTPLRRALDVVSFYHFLRIGDSISRRAARVKVLRFEIGDAADLYQLPDISPGEVINAFTEILHHCRDLRRLQMIQWYYQVPPSHIYRSISHSGLLEELELNVVEEVEEEDVLQLANLPLRTLLCSSTARVSSKPRDYAVLGTGPLARTLVEVQLPLPAHACTLLGATFNSVRKLRISVPRHSTFVNDLRITFPNISHLTLLGQCPWHDPRRPWASRHAEDGNDVIRQAHQQQWKDDPNMLPALKYVRVEDPRAAYILGLNKPISWISIKWLSYTPSHIFPDVIAHTHPTSLEFVLDNPNYRGSLLIDNGPFGGLQELADRPGAVSSLRCLTIHFRCFMIPSVERDLDEALDMLESVLRHLPISHLMLKLDTGPVYPDFLDYIKVTYDPQEGAEILDAAEGWAELMAEASHTLQWFGVYVPKDRVRCWELSRQVSGGEGVESIVILHEMEEDQAWELLLREQLREFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P1N3</accession>
    <name>A0A4Q9P1N3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_949823</name>
        <name evidence="14" type="ORF">BD311DRAFT_651423</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
            <strain evidence="14">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="ML143390">
        <property type="protein sequence ID" value="TBU33919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145145">
        <property type="protein sequence ID" value="TBU56821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P1N3"/>
    <dbReference type="STRING" id="114155.A0A4Q9P1N3"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000014">
        <property type="entry name" value="SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.320">
        <property type="entry name" value="Photosystem II 12 kDa extrinsic protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="424"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="812"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="125"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="980"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU33919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU56821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="999" mass="112286" checksum="9C17DABCF7A724F5" modified="2019-07-31" version="1">MEDAEEGDRPAKRLNTGPTNSRDPIDFLSPPSPEVRIAGQRPAGPNTSLSSISLSSDDSFPDAKDFVNDASQSRIVRGQRVPEEKPSPASFAHANDDEGQFTRFRLTQIEHDTEYVRAAWKEAGGDVPKASALLNDPSWRPPAKTPPPKEPDPPTETGRVKEVLEANRAQRLAVKEKGKKSMIYKSRLVDGKPTSDAGPSTPPPSKGPPIIVDSPFSPEIGRPLKRLKRKVVDSDSEADFVDSDEEDDVHVRKTSSDEQRALEYYNETSAEGLQELTGCTPAQANKIIELRPFTSVDDLNAKLGQGKKKAGPAGISPRMFEDSATIFEGYGRVDSILEDCEGIGAELKKEIASWTHGKSAKGKQRELAQASRDTSVATEDGAITLTHVEVPAQKPKYYMTTQPSLLQPGVTLKEYQLIGVNWLSLLYQKRLSCILADEMGLGKTVQVISFFAHLKERGRDGPHLIVVPSSTLENWCREFQKFAGDNIHVETYYADKNDRPQLRDMLNNSVVTKKAGGWNVLITTYNLAQGDDHDRKFFRKIDWDTCVYDEGHVLKNFQSQRYQALLRYKARWRLLLTGTPLQNNLQELVSLMNFILPDQFADDLDSLRAVFKTKGDSKVTLLAQQRVSRAKKMMTPFVLRRRKDQVLQDLPKKTERIEWCDMTPLQKSIYNDALQRSRKTIFDLETNGAETPAAAATNGRGKPVKKKTRATARTKDKMYLENSANVLMDLRKAASHPMLFRRRFTNDALSGMARLLLKEPDFKKRGALFELVKEDMEVMTDAELQAFCATYKCLRKYLLNEDCYYEAGKIKVLINLLEQYQKQGRRMLIFSQFTQILDILEKVLELKKIKYLVLTGSTPVDVRQSLVDEFTEDESIPVFLLSTKAGGMGINLTAASVVIMFDQDFNPHNDKQAQDRAYRIGQKRDVEVVKLITKGSIEEDMLALGQMKLALDEAVAGEETEERVEHEMKVSLMNAVRKKIVTDDPESKDAQPVEEAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7H2</accession>
    <name>A0A4Q9P7H2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_820489</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7H2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="311" mass="34664" checksum="8F2C25E1C9E87F32" modified="2019-07-31" version="1">METFDPKGNSKATDDGFFMERVEMLYEQGLVDLRAFAEREHRPFEEVRRCMAELHCKFLFDVSSPQAVGTKDREELVHRVLKSVSQELESLETLTGAQSFFVIVNPHDQDDQGFLGGTVVGREFWRGHRGCGAPGAEAFKTQCLRVVPQLTTAAFGPTTRRTVSNANSRKKGPARELKTELYAGVRDALRAVSGVRNAEMKWTNHSKLSAYGVRLDGWPDGVPAQNPSTLSVAQNKLLLDLLHEGKLYFSRLEGRPIPDINGGEDEKLSDRDEDAMFEDSIDYTWGSGEAKGNSSESLFMVSSLRGLCIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7I8</accession>
    <name>A0A4Q9P7I8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clathrin adaptor mu subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_873849</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7I8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7I8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09252">
        <property type="entry name" value="AP-3_Mu3_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14837">
        <property type="entry name" value="AP3_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="188"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU61300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="430" mass="47409" checksum="D1F523207CD77F5E" modified="2019-07-31" version="1">MALDGLIILDTTGRPIVQSGFHSFPPAYPLLHIDAVNTALASAKRPSDVDPVIYVQGLNLESPSACCHMKRGELRYLCPVSGDVDPLYAFAFLQTFVDILHEYFGHLSAETLKDNFDIVYQLLEETLDSGGHPLTTSPNALRDIVLPPSLLHKVLSVAGVSGLASSTATSHPFASPIPWRKAGVRYNNNEIYFDVVETLEAIVNKNGTPAVSTVWGRVDSNCKLSGTPDLLLTFSNAQSLLDCSFHPCVRLQRWSRDKVLSFVPPDGKFKLMDYRYAPATASAVAQTSIPFMLRPTVQIDEHGGSVDLTLSSRLTTRSMENVFVELYLGDGASGASCTASHGASWSYSPKTQTLVWELKQIVPSANYNIRGTFSSTAEHPRPSRAFRVRFEVPQYNYSAIKIEQLKLTGEVYKPYKGMRGSSLGNIEWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7M9</accession>
    <name>A0A4Q9P7M9_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal lysine N-methyltransferase 4</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_944268</name>
        <name evidence="7" type="ORF">BD311DRAFT_752130</name>
    </gene>
    <organism evidence="7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
            <strain evidence="7">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="ML143398">
        <property type="protein sequence ID" value="TBU31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7M9"/>
    <dbReference type="STRING" id="114155.A0A4Q9P7M9"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011383">
        <property type="entry name" value="N-lys_methylase_SETD6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF34">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE SETD6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011771">
        <property type="entry name" value="RMS1_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="194"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU64413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="505" mass="57278" checksum="4B44B4CAA5E139D9" modified="2019-07-31" version="1">MVRQEKEKGTNLLRWFREQHGTLDTSSMGIVNFLGHGRGAIALKDIPEDYTIFSLPRDLTLSTRTSTLPTLMDKGWKEHGLHEGWVGLILCMMWEESRGPESKWSGYLAALPEKFDTPMFWPEDDLKELQGTAVVDKIGRADAERDYREKLIPAVKSRPDLFPEDKLERYFSLERYHLNGSRILSRSFHVEKWKGDHTEDQGADGTEDDGGDDIGMDVDPQEPPADTEQGGDAAEEVEEVQLEDDEESGDEDREDPADVAMVPMADMLNARFESENAKLFYEERELKMVTTKPIKAGEQIWNTYGDPPNSDLLRRYGHVDVVPLRPPLSGMGNPEDVVEVRADLVVSAVSKKVKHSLQERVDWWLEEAEDDVFILRTDCELPEELVSFERLLLLSEDEWTKTSKKSKLPKPKVDPDVLTVAIDVLRARLKEYPSSIEEDEKLLSAGKVESLSLNKKHAVIVRLGEKRILQGTLKQLRAQVAASAGSTKKRGRDEEKSRQGKKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P932</accession>
    <name>A0A4Q9P932_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipid:diacylglycerol acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_947827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P932"/>
    <dbReference type="STRING" id="114155.A0A4Q9P932"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU59715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="688" mass="77374" checksum="1EE999D580060B02" modified="2019-07-31" version="1">MALTQRLKKRNRSDSAVTGSQLDEQQQAANVHNEIQEDVKDTLEDLKGKQKELEKRKDGRRFYTTRRFLFPLGLLLGILVGVVLIHPNDFSDFQTHLALLMDEFDITIPEFSPLEFPLMNFTRVEMEWQRLWKNIPEPWKLNNNGLEFTVGEKIAAKGLSAKYPVVLVPGIISTGLESWSTSLEYRPFFRKKLWGGFSMISQVTFNRDKWIAALMLDPVTGLDPPGVKVRAAEGIDAASSFIQGYWLWSKIVENLAVVGYDTNNLHLAPYDWRLSFYNLEERDGYFSKLRATIEGFVARENRKVVLSAHSMGSTYFLKWVESPLHGKGGPDWVENHIEAFITIAGTHLVRLAKAMSAFLSGEMKDTVQINPAGAYVLERFFSRKERQKLFRSWAGSASMWIKGGDDVWGNVTFAPDDRANATHSHGPLIAFRASSPALDGDSDLYNMTSGPAGTWILERTPTTFQKMLASNYSFGLERDVEKLKANNLDFTKWTNPLEIQLPNAPSMKIYCVYGHGKDTERSYWYTQQNYEYDEIQPDSPVALCAEDDPAHEGNCTSPRPPLDMPMYRATYIDAEYTDEAIDPPVINGVKMGEGDGTVSLLSLGAMCVEGWKRERWNPAGIKVTTVELPHNPVATIPRGGGTTSDHVDILGATGLNEIILQVATGAGDEVKDSFVSNIREYAKRVKWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9G8</accession>
    <name>A0A4Q9P9G8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_921085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9G8"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9G8"/>
    <dbReference type="OMA" id="RIVHHSG"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="106" mass="11579" checksum="4F6031EF8F9D803C" modified="2019-07-31" version="1">MAKAKAAPTSSSGGKAAKKKKWSKGKVKDKAQHAVVLDKATYDRILKEVPTFRFISQSILIERLKINGSLARVAIRHLEKEGQIKRIVHHSSQLVYTRATGGGGAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBS2</accession>
    <name>A0A4Q9PBS2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_817900</name>
        <name evidence="5" type="ORF">BD311DRAFT_652858</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143392">
        <property type="protein sequence ID" value="TBU33260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145117">
        <property type="protein sequence ID" value="TBU59151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBS2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBS2"/>
    <dbReference type="OMA" id="ICVEIAY"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057506">
        <property type="entry name" value="C2_GPCPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051578">
        <property type="entry name" value="GDPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE PHOSPHODIESTERASE GPCPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22958">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25329">
        <property type="entry name" value="C2_GDE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040597629" description="GP-PDE domain-containing protein" evidence="3">
        <location>
            <begin position="26"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="4">
        <location>
            <begin position="251"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU33260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU59151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="600" mass="65506" checksum="F6ED9027A9EB7596" modified="2019-07-31" version="1">MYYAAWYGHRACVALLVQAAAQAHAAQVPKAQESRLTDTQRSTGTESDIDAIPSLYLPPPMMPYRVYGHNYLDKASLVQVTIGHLSSHYQDPSADGPAVRLRHPLAGPQYDDRHLHASPLLKLVMTAAPVTTSAPYSVSLPIRDQKIVFSFQVPSPSALSLEFSLYPNFGTKTIGRATALPHLFQNIQNSQPFTLPILDPRLHVIGEVCPVVNIITPFSGVKLEIGGAVETYWKSLAMPVPGASSAKLLSPRPPQHGRALGSAQTSPSNPTLAQASGHSLTHSSVTGSYIYVTVQVTRDLHSVIFPEWRLPDANYELGVADITLSQFKALASRLGRGAPAPDSSSPPSLWAKWISSSMITLQELLRLVPAMFGICVEIAYPPIQVRRRFSLRNQLDLNDTVNSVLRTVYDMSALEGQMGRRPVVFTSFAPDLCAALNWKQPNYPVFLASQCGDASRATPSATALSTDDAHDHRLWSLDAAVEFAKMNNLLGVLLDAGLLVCDFVGLAEKRQASMSRSFANDNIGSSALAHTGRERFWPAGGHVRPSGGHREAAHISRYGSKRRGCRVARRRLVVLQQQTQGNARTMTYIRRSDPDGDIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCC1</accession>
    <name>A0A4Q9PCC1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_940221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145250">
        <property type="protein sequence ID" value="TBU52440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCC1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="61" mass="6579" checksum="2AA58D67C8830FAE" modified="2019-07-31" version="1">MLQSTAAWPHLRSLELSGEHPVGLPESTSNKPVRMPELRVLALAQVGSARTCRSVANVTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PCR6</accession>
    <name>A0A4Q9PCR6_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_983020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145444">
        <property type="protein sequence ID" value="TBU51017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PCR6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="238" mass="27583" checksum="B165D642794AD4F3" modified="2019-07-31" version="1" fragment="single">MALPSFRFKDRSASHTAAGQSAKDATRQSSEVQGSTTREVRILYWTTSARVPETTIVDVTIGKFLNVRRWIPSVRFGGMHWFVQVWNEDLGEWISTFRWDVQVKIARHTVTVLVRELDCHVCLALGREVEIQQMRRGIEKIEEWEPVDLRVPSPTKVGEDFTVVSWDATGAVPQVFIVTLTNQGRLIIEDFPQLAEHCFHDRHPRPVFCGTRVWNPRTLKWELQSELLDYFPLKGYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDN1</accession>
    <name>A0A4Q9PDN1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_890858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145337">
        <property type="protein sequence ID" value="TBU51347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDN1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PDN1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="245"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="287"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="330"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="501"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="588" mass="64889" checksum="1AC570FD24C98385" modified="2019-07-31" version="1">MFSIDDPAESQHPSPLLSSITQSAPALPWEVIETAIDLCSGDNATLCALALTCSQLHPRSLLVLFTNVDIHSQKQLKQLYDAVQAKPHLQPVVKSLSFSWDDVSPFPLLSILPGLRDVTFKRISSVIRDDSQLPLLTIRDASFQTETIFLRFLSAFPNIENFTCERLSSQSHTPLGDLHLPCRPKLRALNNALLTYPAHRALLTVPGGPVLNVRSTISWSDEIRRLFRPFGEKWAMAEDVRSSCKPGHDSGITALVISSDGRWVATASEDSIIILWDARETCISQEWFAHNGEVWDLAFSPDGRRLASAGDDGTVAIWDISGSSRQVATLEGHPASVIDCTWSSDGRYIASQDTDSLVRLWDGQTFQPLPLDGANKTTYVKPLFSPDSQWLLFHERRGCGVWNVVSRTYLALRLQLEGKNKYPITAAFNPSSTNVAVGYDNGIIRVWDLANSGEPLLLQAYEPLWVRDVAFSPGGQLLLSASDDKTIKVWDARTGGLVQSLEGHEDQVRTACFSPCGKYIASASDDSTVRVWRTSDGSCLATLSDHGSWVEYVAFTPDGTMLWSAVHNGTVLGRRLKDIIPDDTRIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PF41</accession>
    <name>A0A4Q9PF41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_831490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145237">
        <property type="protein sequence ID" value="TBU52775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PF41"/>
    <dbReference type="STRING" id="114155.A0A4Q9PF41"/>
    <dbReference type="OMA" id="HRCPWAH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098754">
        <property type="term" value="P:detoxification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00570">
        <property type="entry name" value="GST_N_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005442">
        <property type="entry name" value="GST_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050983">
        <property type="entry name" value="GST_Omega/HSP26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43968:SF6">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE OMEGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01625">
        <property type="entry name" value="GSTRNSFRASEO"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="252" mass="27791" checksum="D4D21BC3FE3F0B46" modified="2019-07-31" version="1">MPEQITLYTAKVCPFAHRAELALAEAKVPFTRYEIDLQNKPEWYAPKVNPASKVPAIAYGGPQVPPDQPSPESVKLAESLVLAEFIGDLFPESGILPKDPVKRAQARFFIEGVSSKFIPAYVSFIMKSEGSGEGLYSALEYLQSLLPPEGFAVGEYSLADIAIAPFFGRARVLLVNDFSKGRAVGEGAKIWETINTGKFARLGKYVDDLFQRESYKATFDEVRLKPYRGGTVLTPQQAANNEGYRKLFARAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG74</accession>
    <name>A0A4Q9PG74_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_982162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145272">
        <property type="protein sequence ID" value="TBU51991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG74"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU51991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="346" mass="37846" checksum="73506E6B2DABB54A" modified="2019-07-31" version="1">MSAEDSFPLPRAELIALFLESLLFGAFAVLYSISIWILLYREKHHGRSKVHKWMFATATTMFVLALAHLCFDVQRAIEGFIANGGTPSGTADFYNRLSNPTHVAKSAIYITQTLVGDAFVTYRLYVVFNRNPWILVLPLSLLVGTGIAGYGICVVLTQIKGSGAIFSRNLVPWITSFFSLSLTTNVITTTLISGRIMWSNYRVRRYRAGYAAVTHWGVVETIVQSAAIYSAALVSLLATYVSGSNAQYVCLDSLQPLIGIVFTLIIIRVGLNDTTSEHSKGHMADSRITTTAPVLPPNVAGYPLRPLAISVSVSRTHDRTSFEGFDRKEAAVTKDSDIESGHGSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PG93</accession>
    <name>A0A4Q9PG93_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metallo-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_940828</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145263">
        <property type="protein sequence ID" value="TBU52162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PG93"/>
    <dbReference type="STRING" id="114155.A0A4Q9PG93"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF11">
        <property type="entry name" value="METALLOPHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020909890" evidence="2">
        <location>
            <begin position="23"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="61"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU52162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="396" mass="43870" checksum="A03D9044D08EF464" modified="2019-07-31" version="1">MLSVLQLLMASFGVASLWICRAAPVAQNRVGFPRAAAQSDDFNLNPYPGKPRLTFNEDGTFKITVFSDLHYGENPWDVWGPQQDVNSTTLMNTVLTSEKPDYVVLNGDLITGENTFRENSTKLIDEIVAPLNKLKLPFSSTHGNHDNEPNITHAEEIKRELQVAPLSYTRFAPSWANGQGYGPGTYWVPVYTKATDHSPSLVLWFFDSRGGFSEGVNSTRVPDWVDENVATWINLTVATMDAAWGPAEKVNRGSLAFVHIPPHVVQDLQPNLNSTQDPGLNADELGSGSTQATTLPQDADKDDPFWNALNAQVKNLHGVISGHDHGNEWCKREITKNVIFCFDKHSGYGGYSSTGWGHGVRNIVFRSPDPNVGPETWIRMEDGETHARIIMDSSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PGB3</accession>
    <name>A0A4Q9PGB3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_345305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145318">
        <property type="protein sequence ID" value="TBU51476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PGB3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PGB3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="67" mass="7524" checksum="A1BBA50AC95E890F" modified="2019-07-31" version="1">MNALSTALKVNVNIAYLDGHDPQGQVSFVPFQNAPFTFIEPVNLLYRPGHYDILDRRDADPMPPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHA3</accession>
    <name>A0A4Q9PHA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_832811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145263">
        <property type="protein sequence ID" value="TBU52176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHA3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHA3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13391">
        <property type="entry name" value="HNH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH nuclease" evidence="1">
        <location>
            <begin position="12"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU52176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="105" mass="12149" checksum="2B0FCD9340EBBB0A" modified="2019-07-31" version="1">MVDVVRDRDKHCQVSSHQYVHRDRGDDWISLEVAHIYPHAYASKMVRGNHIMKLCGYGGVVNRAPNAEGADRSGNAFLLRSDMHQYFDAYHWSIDKVRGELSYNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHQ1</accession>
    <name>A0A4Q9PHQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_938477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="protein sequence ID" value="TBU53231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PHQ1"/>
    <dbReference type="STRING" id="114155.A0A4Q9PHQ1"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="27"/>
            <end position="151"/>
        </location>
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        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
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        <location>
            <begin position="702"/>
            <end position="738"/>
        </location>
    </feature>
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            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
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            <begin position="75"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
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            <begin position="105"/>
            <end position="115"/>
        </location>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU53231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="738" mass="80241" checksum="0B9AE9DA5E6E001D" modified="2019-07-31" version="1">MLACMSPSLAPLPAPFLVLPASVPSLKRPRGLWKQRRLEAAESSPRSPWPLQEATSHARPPPASTSPRPSPFGSPRPSVAGSPTPSLLHLRSPSSSSSTSLTASADDENAYDDDQGDSHSDSPLSPKRRRISGHFSPAHSAPSPTSGAAPGCRCESITPIPNPHATAVAPLRLPPLLALSMFPQPVSRSISAVSTTSSDSSLSARGKHRQSSVQTQTSIHSAGYEDWENLKELFARAAERYDADDIPEALPLLRAVIRECHRFLIDHPDPSVVYTHPKPKRLSRSPEGAITPTEERLHRDWGTDLLVDTPNLTGWSSRRRSSTTTKPSRQAELPTAFHAIFGITLFLMGNLVAQDPSIVLPEEPDAPSTYWLAALDVFETGENLPSRVGGTDLDAAEDWRMAIVWGRTLVCLADEKVTHNIKMAKEQAEASDASPNHSSYFSTASAFSMSEPHWPPSSPFHAIAQFRPPVTRRMSLYSASAHDIMVLAMDQFSRGIFHMPHPHYSHSHNPSYVHTPGVAPSAYQNSSYFSSPQAPPSHYASPYVPSTDPLISFSRPQELFTIASEVLGVAERLSSGTQRHYWASWADSVFNQMKNEADMDAWRAPILSARGRCWLVMGSASVDDMEPALEAGDLEVLHTPEAEEAREGLAMAISFFERAKGHLADSMNTAGRECEDVSPLLAEALLVLANLTADENKREELYTRAQAEVGEDLKLDSPDASSGSNAEADADDAMDTSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PHW6</accession>
    <name>A0A4Q9PHW6_9APHY</name>
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        <submittedName>
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        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">BD310DRAFT_139658</name>
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        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="TBU53587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PHW6"/>
    <dbReference type="OMA" id="GCKGPYI"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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        <location>
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            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
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        </location>
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            <end position="241"/>
        </location>
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            <begin position="316"/>
            <end position="337"/>
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    </feature>
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        </location>
    </feature>
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    </feature>
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            <end position="419"/>
        </location>
    </feature>
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        <location>
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    </feature>
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            <end position="123"/>
        </location>
    </feature>
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        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU53587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="419" mass="46624" checksum="DE720A45ABF26F44" modified="2019-07-31" version="1">MERSPSHSRSSSVNSHSPSIQSAANSTRYMLAGMNSNSSGLDPPTLPYGSRASSFRSMSPKNDTPLMDGKATSLSVNYLPSKFSSNILSGGMKRRKGKGGDIPIPKRGGGREAFRANEARMPGDGDDDYDGVSFGQGGRKGRLRWNRFKWILFFSNLVFSVYSLTGLIATLLIHFNVWTHADIIRVGNKTELIITTVAASLAVLTSLIGWSGILLNNRAFLATYSFLLWICFAMLVTPGYITYKKRTFNLEGKVNAQWSRQLGLDGRLRVQNQLHCCGYFNPFVEATVSQTCYARSLLPGCKGPYIQFERVILERWYTVVFSVVPVQLFIMVAALLCSNHVTYRFGKGMMPKAYRLNMNSMAVIMDNYANQLAEQYGNDVASEVMARSRSNLQLDSMPTVPYNQSNSPSMAGKYEQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIN4</accession>
    <name>A0A4Q9PIN4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_937142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145202">
        <property type="protein sequence ID" value="TBU53921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026913">
        <property type="entry name" value="METTL24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32026:SF10">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13383">
        <property type="entry name" value="Methyltransf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="98"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU53921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="41765" checksum="E8ACAF724F406C19" modified="2019-07-31" version="1">MAKSPFVLTVQRHPRYTLALAAFVLCAYWFLSTPTLPPSPVRYNANNELQARLEREERKYRAMLPQRQELITRYGPTPAQVVMFPPDQDPWPPYTVWDFFPPLYNCPHELDRLGALGDGGKWICGMSRIQDKPDCVIYSFGIDSTYLFEATLLQSTRFCQVWIYDSTKGAGAEGHIPRALRHRAHFGKLALGASDRHGAGDEPKTWTLKSLMAENGHSHIDFLRLDVEGWEWETFRGIVRDFTMERGNPGGGGPHAPNNDNATSGWGVAEREGVLPFGQLQIELHVWNQRFQDFLEWWELLEVAGLRPFHNEINLVYANYNRHSGVELAEYSFINIRGENAFIKDYVPVLPETTPPRGPGIGPERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIP3</accession>
    <name>A0A4Q9PIP3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_936966</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145201">
        <property type="protein sequence ID" value="TBU53925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
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    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6533" evidence="2">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="39496" checksum="A94DAE74849C136F" modified="2019-07-31" version="1">MSSTNSSAPGEQHGLQDWILESVQHYQSYQLAACTALTSFALLLFEYVTTFDREIRYLSDGKRTWAKAVFILNRYISLLQSTATLFCALSSPSLFYRSCVILPRIIEASAVLLCAVWTVFSTLRVYAFGGNKAAIAVLVGLLSCVTVIADSVLIGFSYMVKARLPLSPYPEFCTMAFDIPVQWEQKVTLQVAILTLLPLPIAEAIGILAVLVQLRNMVFGPNKPRAMTQLAQRIVREGFYYFVAIMLINTASVIANFVLDVQFISACAIFNILIPVLVSRFYLNLDDVRSTEGQCERIHQVRLGVECSKTSYAAFKPISPLTERANPNNVNIHYAEEVFRYNQRLLRKSDALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIV7</accession>
    <name>A0A4Q9PIV7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_110870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145200">
        <property type="protein sequence ID" value="TBU54002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIV7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PIV7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF2">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="2">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20278" checksum="CE4B605807C7EC2D" modified="2019-07-31" version="1">MPLISDFPALPGFYQLLFLHIEPTSTIMPAVMAWLSPGAAWFHNQLIPDGTPIPVALSDARTKMAIWQLGNCYLLLGMISSFVFRAVRDALPDNPVAQERIMGASFTALALADVTHILWSWVGLPDDLKYDLARWNSMTHGNITFVIFLLGMRIAWFLGIGRTRYYFGQPSSASTSAVKTKAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PIX3</accession>
    <name>A0A4Q9PIX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_859261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145199">
        <property type="protein sequence ID" value="TBU54021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PIX3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1043" mass="111105" checksum="8B3383D98DF1D234" modified="2019-07-31" version="1">METRSLAIRVLYTINSAEPYILARTATAYEVQIIPPRPPHLSPDSQPIYGKIPLRPCLHVVCQSSPEVVPAASRDFTVYVIDPIESHLRMPFSSLSAPPPTVAVGHGWLSDALTNDNSPFILGTLCSDGIYPDSIEVIFSLKQFPRPPPSRANSSVPDRKPTKRTHGALFTTDPLRWPAQEKLKASDHLTPPVIQDPLLSGFNPSLLPTVLPPVKQDTPSQLSTLPNLTMSLPAVHPLEPPSVAPQSASQGIPAQVLLAALAGSQENHQRLLSLIGSIDSTSSNSEPSPELVQMIRALLSSAAPSVAPSATVPSPSVSVTHVSSSVHVDPYTPLTFLSATAPSSAATNFPAEASQSPPAVIASASTPPTTDHTIDDEIVVLDKENVNPVAFRRKGNEKEKPKETALPQHRTSALRLNQSEPVLRSRASTSENATQSSVESAGVNPRKRTLSDFMEERERERNTSRKRSTKAARRPSTGFGSVLSSRGIHANGAVDAVDNSSRLAPHTASDPAWDNTSSHHGAFAVVPSTSPPRRSSSSTNPSARRKPYVVPDWARTTTATLPRAADGSFLTGEGEPSETSARKRPVKKEKEKATGPKPRKSRATTYKNPSESIEERTFHGPATLTPPRTASSGSPSAPADPPRPVVASSPGASLFPMPFAPSSSHNVLAPSDNIEPPSTPNRRRTVGSNPTTPEDGIGSLFTPESNRDPRTPRKLPSLYSGFSMSPTRSLVRRHRTPSKRSGQPTSSRSASSVPDAPSAAQHGGNHAEPPSDDLDIPLDSIPIASSDGEFDVGSQDGPSDYLDFGQPKRRTFGLPPSSPLPPSSPILTPSDADDWDSAQEPDEHQHDETQNAICLPQFEISTTENPDECASPTSEQELLALLSQPHSDMFSDSALGANFFDDEFLTSVTSTSSGHVADSGQAQFLQGQSLPVDGDNGFMSSSALPDFGFDNAFDPALYGSTEFYGAESVNDHDVNELWAFLAPVAGDSLIPLDNQGEFRATGGSDAPFSEKYAPLPGSEQAQFAIDPLKMAESIQGLLSGCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJE1</accession>
    <name>A0A4Q9PJE1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_936433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJE1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020236749" evidence="1">
        <location>
            <begin position="18"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU54213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="203" mass="19383" checksum="541A227326A30636" modified="2019-07-31" version="1">MFSKLAVTFVLAAVAVANPVPQLPTSLPISIPALPTSLPLSIPTSLSVSIPLALPTDVPGAVSSVADALSSIVGGAVPTGVPGAVSSVVDGLSSIVGGAVPTDIPGAASSIIGGVVPTGLPGALTSILGEAVPSVVPSISLPVSVPSISVPSLPISVPSISVPSLPISVPSLSVPALPTSLPISIPALPTSLPISLPVSLPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJF0</accession>
    <name>A0A4Q9PJF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_936453</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145194">
        <property type="protein sequence ID" value="TBU54223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJF0"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJF0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="25"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="315"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU54223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="382" mass="44125" checksum="13970A322D6CD3A2" modified="2019-07-31" version="1">MAASFSDGIGIANLPNQRHKIVAKRGAHFTIMVVGESGLGKTTLINTLFSTELSPAKNYSRRHQKQLDKLTEVEIIKAELEEKQFKTKLTVIDTPGFGDYVNNRDSWAPIVDFIDDQHEAYMRQEQQPERKEKIDLRVHACLYFIRPTGHTLKPLDIEIMKRLGTRVNLIPVIAKADTLTHADMHTFKDRIRQVIQAQGIRIYQPPIEADDEVSAEHARVLTEAMPFSIIGSTEDVVTPDGRTVKGREYLWGVAEVENEAHCDFRKLRSLLIRTYMLDLISSTEDLHYENYRQAQMETRKFGEQKPRKFENPKFKEEEEALRKRFTEQVKAEEARFRQWEQHLIAERDRLNKDLEMAHGAIKALEAELDNLQVGYGRGTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PJR6</accession>
    <name>A0A4Q9PJR6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HAM1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_951521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145191">
        <property type="protein sequence ID" value="TBU54347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PJR6"/>
    <dbReference type="STRING" id="114155.A0A4Q9PJR6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="2"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like N-terminal" evidence="2">
        <location>
            <begin position="165"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="746"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU54347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="908" mass="97437" checksum="62F6DF3DB588DD6D" modified="2019-07-31" version="1">MEKNDDDRLQDLLYQLRSITADSVHADVALEVAQEVNVDVSAVVQELPSQEEAAPDASSLLHSIYTLAYVLLTSAAFRVILSDVLLIARQAVADVAARVGNAAATVENIADDIEETVRPGGGTVEEIRWKASEAVDNITDGALEGNPHDYATGSTPGITEQIQQAPDKMKEAVIRQLQDAVARAHRQPSFRSALRTILNISRKYAMKVRAASEAFSDASAPVFTLTPVVWADPPVSRALENLRILLERMSSGYDLSYLLSASLAVITDIVAAPAEALSESESKVVLRTWFGSLGDWLDCALRDPKYVTSETGCMRIEQLYDLAHKLVQDAEADPESHWVQHVRTFLAEVDSFISALGQDRTTNELIKSLSDLATSVADAGADFRASLPGALRGRASLARREALQSFALWLLPRILRVASAIPMPRIEYVDSTIEAVIDAILLTAPRHGVRGEETLGVQSSLVPDRVSVQSWNEVVLDIDNTIVLPQPGPSLLPSLAGTLEQVGLAEAVEEGPPLPASKIQSQTTRTSVSARTRTRVHVEGVRVSAHDVAYYMLYKGARCCGLRVPFTSYEDEGLISVDVGNLDPDPSRGGTGTGLVVDVELEFDSGAAAQLESNSTWLSLFTSSDPGRAPSAGPLFKVTDVHVDVRGLHIDLARTRHAILNGLFVRPLAGPSARAAVAWVLSGQIRTALESLAQFGGKVRERALARQGAGSSKPSSEGAEDGSEESAGAAEAWWGAFLEELGLLGSAQGQPGLGDDEGTYEDEDGDEETPLVETHTRATARGVIRTTVIQDSASTGADPEESVLAVGIGPQILPGKGGPYSERSSQDSDSLADDLSLKDARVRATEEARDAAGEVTQAQESAEESLRADVEQVVQMREEITGAEARGEVRTRVERKKKGWRSAAFDLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PK26</accession>
    <name>A0A4Q9PK26_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_951448</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145188">
        <property type="protein sequence ID" value="TBU54483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PK26"/>
    <dbReference type="STRING" id="114155.A0A4Q9PK26"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 14" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="13">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU54483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="526" mass="58771" checksum="3678D3FDA39873FD" modified="2019-07-31" version="1">MIFSLSLVASSGLAALAILLIFLYRSASSVPGPLPPGPPPLPLVGNIFRIPKIAPWVGYQELSRQYGKIMSLKAFGQTFIVVDDADIAMDLLEKRSAIYSSRPESNMVALVGWDWNFGMFPYGAQWRRYRRMFWQHFHTGVVSKHDPHVKRGAAILLRRILQSKPDPREDIRHSLAAVVLGMTYGIRIAEKNDKYLAIIEGGSATGEHLITATSILEFLPVLARLPTWLPGASFLRTLQRCRKAVREMRFVPWNDTKHGIMDGVYDASNIAAEMREELSRLTAESVAEEEAVALDIAATVYSGETTQLISLTFSTLCGFFLAMSLYPNVQRKAQAELDAVVGPGRLPELEDLDQLPYVNAIIKEALRWHHPTPLGLPHANTSDDEYCGYFIPKGSTVIVNVWSILHNPEYYPRPDEFVPERFMKDGNLDAAVRDPSTVAFGFGRRVCPGRHLADNMLFIYISSVLHTYNITPPLDKHGQPIHIQPRGKSGIVSYLEDVRCTIKPRSTSAEALIRTCADGLLETRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLH7</accession>
    <name>A0A4Q9PLH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dynamitin-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_857456</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145176">
        <property type="protein sequence ID" value="TBU55047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLH7"/>
    <dbReference type="STRING" id="114155.A0A4Q9PLH7"/>
    <dbReference type="OMA" id="YKFGDWE"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15346">
        <property type="entry name" value="DYNACTIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="383"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU55047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="48140" checksum="E82E50BD16574CC3" modified="2019-07-31" version="1">MSAKYANLPDIDTAPDVYETEDVFPSAQDSKGDSSDDESGAPTRGHGRGKSETGTGREELDSSSVDPDDASRKFRKAEKKHRRPKIQYVYPPSPTGEEQSGPPSPTQGPLPLSQRLRLLQAEVAALEVELSDPTNPLLRKEKESGNADPGELIRGMVDVKRRIDKISKAREGRGKLVSVVLGETTDAEDDDVVKVTAEDKEEGTKAEAERKTEAAPPKLKEPQARDVAEMDRRVGELEKLVGSSNATLDELSPLPPPLLPLLTRLNAQLTLLTQPRHIDSISRRIKLLNAEFERANATSSQAHGAQRRGVHHSAANPASPSVASPSTALPAPASSASSTALQEQLAPILTRLAPLLPHIPHILTRLRTLSTLHTSAAGFQKTLEGLEEEQRRTRAALVDLQKAVEGVEKSLAENEKLVKGNVRELEDRIDGLGRRVDDMKVGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PLP7</accession>
    <name>A0A4Q9PLP7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BAG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_884826</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145174">
        <property type="protein sequence ID" value="TBU55127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PLP7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.120">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036533">
        <property type="entry name" value="BAG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003103">
        <property type="entry name" value="BAG_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02179">
        <property type="entry name" value="BAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63491">
        <property type="entry name" value="BAG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAG" evidence="3">
        <location>
            <begin position="428"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="486"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="540"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="611"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="695"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU55127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="712" mass="79140" checksum="579F4C247DD7415B" modified="2019-07-31" version="1">MFPYYGYSAPSYSVPSDSEYLRALAEERAAREQYAAARRAQEEARARAARARAARRAYASPYNSYHDDDYLDSYNDLDLGLEPLDDALGSYYPGPSSARSRPLSYMDGQRPYGFGLDPYSQRAMLEEQRRRHLMEEQRRRELLELEREKERRRLEEERIRRILQEERMREEAARQKLLEEERMRKALEEERIRRALLEEEEARRERERERARIREQQQQKPIDPLDILRALGLAPPASVGESEKERLGRQGARTTQPGRRTGTTPSPVRPFPFGQTPKTTTTQRQRAPSPNPVKKTPSSQSTSIPITSPKSSAKRVPTPSPAQPPTPEQLAAAEKIRDAYRARVSRRAALASIAAIRKRFLAARNGFTLPSTLDYDIPTNGRVPTTVSLGADTSVEKLARLAEDDEADVLEGAPRLAYSPTNAPLHGYEEELNRILGQLDAVESRGDQGVRAARRELARAVEREAERVERWRGVVWRWWTEDQPKEAAAPAESQQMEVEPVESVQTSAEVAQVPQGETSESAATETPMEVEPTTEPPQPVSDSSAATAVPPSPSNGTNSTSFSVPISSPTPQAVEPVESAPTPEIEITDANDAEAPSQPEAEPADIDVPVAEAASSPESAPSQHAQSDNTASESAATEERARSLTPELSHEHSEAEEMEVEPQEVHTPPPAEHTPLVSVDASLPETMDLAHEQQKQPTSEANPIEAQQQQVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PM79</accession>
    <name>A0A4Q9PM79_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_884665</name>
        <name evidence="9" type="ORF">BD311DRAFT_724845</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143436">
        <property type="protein sequence ID" value="TBU27126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145172">
        <property type="protein sequence ID" value="TBU55246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PM79"/>
    <dbReference type="STRING" id="114155.A0A4Q9PM79"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="41"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU27126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU55246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="470" mass="50534" checksum="9D59B7A3328C11C9" modified="2019-07-31" version="1">MADSQTPAVPSRCPSPAPTLIDETKEGPTVHEYSPARRYTLLVIFCLAQFLDTFNVTSLYSAIPAMAMSMGIAEGESTWIISAYQLTFASFLLISGRISDVYNPKFAFIGGVFVLAIFSLCSGFVSSKIPLFVLRALTGVAAAMAIPSAVTLLVGIFPEPTEQSRALGVFGGCGAVGIVLGLVIGAIFVQYASWPWVFWFVAIVCVPIVGLSVFLIAKQEPKEVRGGGAKWKSLDLFGVTTLTVALILFIFAVTSAATTGWGSSRVIASLIISMLMTAGFFYYETRIPADQAAIPPRTWFLPNFSVLFGTALFPFFWLPIGVSSFPVSLTGPLSHKINPKWLLLFGEALCIVSTILLAFADRPTRYWPYMFPGFILGSAGAMFVYTHTNIAIFRTTPASMAGTVGAIVNGALQLGSAVGISIVGSIESSIEERHAGYAGRAASFWFLLGIGALEFIAMLVFYRIRKENAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PMS3</accession>
    <name>A0A4Q9PMS3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Frag1/DRAM/Sfk1 family-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_933358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
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        <property type="protein sequence ID" value="TBU55559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU55559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="282" mass="31395" checksum="BB0B06F6F8576201" modified="2019-07-31" version="1">MSWKQHNHWLYAWIPLFGAFIWFGMLWAMLITWLAEGRPKYPTQTGKVAYISDVGASFLKPLFITGCSITAVCFVFALVVERWLRHRGRLVPNMRRRERVLSTCAILGSVIGGAGLILLSIFDTDRHHSAHRIFLLVFIVGVGLSAIFTILEFRWISHDFVEIRKLKAAYITKGVIAGLLIILAIVFAVTLFEAVDVGGVIEWTIAFGFTFYLLTFVWDLRMAKGVRAGELKREHLLAMQEQGQGGEAMRETHAAGGDGMLGRQLGNTANGDHAVGTNGYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PNA9</accession>
    <name>A0A4Q9PNA9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_669726</name>
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    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145163">
        <property type="protein sequence ID" value="TBU55762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PNA9"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <dbReference type="GO" id="GO:0005739">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051035">
        <property type="entry name" value="Mito_inheritance_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36091:SF2">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="115" mass="12861" checksum="7F238E0FB202DC0E" modified="2019-07-31" version="1">MLSCLGKARLVFHLLKAPANLRLFFSSSPSNVSTMTVSLPRRALSTMADFQNDIFNYTSGRWVYNDALRHKERRVAFDVDGLRRLAAESVNQGADDVVSLSKLAEGGFNRTFLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PPI7</accession>
    <name>A0A4Q9PPI7_9APHY</name>
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        <submittedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_632134</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the cytochrome P450 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145154">
        <property type="protein sequence ID" value="TBU56262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="114155.A0A4Q9PPI7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EP450I"/>
    </dbReference>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
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    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020981347" evidence="11">
        <location>
            <begin position="23"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="479"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
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        </ligandPart>
    </feature>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU56262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="542" mass="61285" checksum="5A6A8A974024B90C" modified="2019-07-31" version="1">MPALAVSFVFVTLALFLAVVRRVVDRKGIKHVRGPPSPSFLCGHEEAYVRQEEACDLEFKWMREYGYTWRTGGAFGTDVLTTVDPKAMQHIMQKSGYNYTKKTTSFHMSWLMSGPGIVSVLGKDHQRHRKIMNPAFSAAHLRTFLPLFQRVAGKLSEKWKADLMATGELNTMLNTWLSRATLDVIGEAAFDFDYNALDGGERSAISKGYKDIFKDVDYQLGKPSILFRASWDYLPVPLLKVIKYIPAHPWTRIRDLNNLYREYGRQILHEQAPVVDAEKKATSKDIMSILIKANSSEDPKMRMDDEEIIAEMYTLTIAGHETTSTTLTFLLYELAKNQEYQDRMRQEIRSVRAQITARGGNQFTIEDLDSLTLTMNAIKETLRMHPIVVGLHRVAEKDDVIPLAYPVTSTTGEVLTEIPVRAGQVVFLSYAGYQRLPEVWGDDTNVWNPDRFSRLETGKQTNVGVFANLMAFSAGVRACIGWRFSLIEMQAFLAELLDNFQFDLPAEKVEIQRALAGIVMFPIVKGKESLGGAMPMRISLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQF3</accession>
    <name>A0A4Q9PQF3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145151">
        <property type="protein sequence ID" value="TBU56444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQF3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="334" mass="37064" checksum="B604F7107D01741B" modified="2019-07-31" version="1">MRTRASTANENHHQQVAGRTAGLTTLSRQDVEDDLSSIDGSALTDDDGDTVMGDDETVMGDDDERPQTPPRFGSYDPGSVLLTPNKNKPRGQSHAQPADDGLRHSNHGTRNINDRVAFLRDPSLAVISQPAAPNGEGEERPATDRKRNKNKRLVFKEEPSVHLIPARSSSDENSEPGPSEPQAGPSTSDGSRASQEDGGGFTSEWNGSVRWYHDDHGTFVRDGSLPPEYYSHWGFPRELQPPRADSLQRPPERSPPPRLQRTDTELVIDEPQPSRQAQRAQPARRAPGAQPIAREQSIILERAPTSRKKQKDAQQLPTPRRSERIRIRMLTARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQI0</accession>
    <name>A0A4Q9PQI0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycopeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_854522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQI0"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5021005320" evidence="1">
        <location>
            <begin position="22"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="16037" checksum="A22CFF057C430D51" modified="2019-07-31" version="1">MQYQLSVTFIAIGAFVGSVLAETHIVQFTNNCGFGTPTLLQNGNILSQGATVEIEGALISAIAYLQTGGCGLNGEGCTLIETTLVNPTSPGSGSSTDISLIPPHAFSVTSGFGYFGGCDGAGADCTGPDCSTAFHSPGDTGVQVACQSDNVNLAITFCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQL2</accession>
    <name>A0A4Q9PQL2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase cytochrome b560 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_823230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQL2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PQL2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018495">
        <property type="entry name" value="Succ_DH_cyt_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02970">
        <property type="entry name" value="succ_dehyd_cytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01001">
        <property type="entry name" value="SDH_CYT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="27195" checksum="F224791140728D03" modified="2019-07-31" version="1">MSNPSLDKYHTTFSESGLIQAVVMARPRRHLILCALVPIKAEGYTAWHPGLTTKPLPRQYTSLASQPHPHPHVTSSHRRFQNPPSTERACAPEWSYALLSVVRRRRIQTDSLPPSAHQEILNGQRLRRPKSPVLTIYQPQLTWVGSVLSRFTGTGLAVLLYGSALVYLVAPDTFSSAQVIDFISTLPDAVKYAGKVVLATPFAYHSLCGVRHIAWDVGKFLSLRGAYGTGYVVIAGTVIGTVVMVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PQT7</accession>
    <name>A0A4Q9PQT7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_930932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145147">
        <property type="protein sequence ID" value="TBU56727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PQT7"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="245" mass="25913" checksum="E238CB4CC078EC84" modified="2019-07-31" version="1">MQFVPYSSYCDVCRLPVFARPAPDPPRLRHGQARVPRRPLHAAHDRLNREHGFLVGPHAPHLDKPPAEVYPLAASCAACKTDASAQDDMKRCSACRMTRLADCPRSLCFPDPCEGALGIGRAGRNAAADGRATACAGTAATTASAKTGRATGPRASASSPCSSRPSPPDSPRPLYPPWVACNEDSNYCGIGSGLAGHRRSTNANGIQERACAARERAAKGGHVLSHEHGCKASLLFCSYRCPSLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSE3</accession>
    <name>A0A4Q9PSE3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_880976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSE3"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU57346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="79" mass="8083" checksum="7BF560260251CC13" modified="2019-07-31" version="1">MASPNATIGATLSSAIWTLWSTPMVPSEQKHISNAVPLKDMSQRQQSHSRASSVSSVVSAASSTSGAGATYPPSVPRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSK2</accession>
    <name>A0A4Q9PSK2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_772284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145138">
        <property type="protein sequence ID" value="TBU57344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSK2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PSK2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048661">
        <property type="entry name" value="CPL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038955">
        <property type="entry name" value="PriA/CPL1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192:SF2">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35192">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21671">
        <property type="entry name" value="CPL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="2">
        <location>
            <begin position="117"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Protein CPL1-like" evidence="3">
        <location>
            <begin position="240"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU57344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="319" mass="31833" checksum="FE8A2825610E9B00" modified="2019-07-31" version="1" fragment="single">VALTLASAPSLVVADSCPPGSFSLEGLTPCTLCAPGFFQPNAGQTSCIAAQAGWSAAGSGPGGSGATHQTVCKEGTYTAKAGSAACATCPPGSYCNGEGSTSPTPCPPGYFSDTPGAGQMCTPCPKGTFQANRGATSCCLCCSGFYNDQTAQPHCAQCPVSGASSLAGATASTQCSSKPNGGLSSCTESSAGTCPNTGGSPTHAPAARRRSVRRDVCPRGTRSCPLYGAASGGRGFLRGYECVDVQNALESCGGCALNESPFGEPSADGGRDCSAIPFADDVGCRKGRCVVEKCRDGYVPTADRGSCVAQAEGQTAMWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PSM4</accession>
    <name>A0A4Q9PSM4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_949424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145137">
        <property type="protein sequence ID" value="TBU57432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PSM4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="36653" checksum="D1DE1D40E97ED7D0" modified="2019-07-31" version="1">MPTEVWERVIDLCRTNWRLDGTRSTHPQVETQLRTDGTYETWQMCALVCKSWLPRSRYNLFAEVCISRPEQIDQLLRTLENHPTLAEHVVRLTITLPPDATTGYIPFNRAPLSQILSNCRTLDLRGVDWRHYHPRWHCLHSVPHFSWAHVVELFLPIDYLTPGGAARLIWSHPALAYLTLFHGLDYYGKLRASSIPSIHPSYQTLASRRERPRDACRNLSEVHIVTRSAVSTTISFPLQHLLGHTVTRLTLAMSRSSIDSPDLWNYIACLEQLEILSVSISASEYDPYSAFEDTLPTLMAHVKSRTTLRTLVVRHYSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PTG3</accession>
    <name>A0A4Q9PTG3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_928728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145134">
        <property type="protein sequence ID" value="TBU57634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PTG3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PTG3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU57634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="262" mass="30688" checksum="4B5806FBFA13E540" modified="2019-07-31" version="1">MSGTAAGPFLPINLHAIAAKKDTATREERRALHDAVQRRQFVEDMMELKGTFFPGLDALRKANEAPESSVDLKERIQEVKQKHLEEVRTLYEWQAQDYFDEVLDMSRSKPDVDLPDVEEFYRLSRSSHEIAASFDDQLDRHHYAHLTGLYPLMKQYNILRGVEEERQKQRDKQFPSSIAEFRATRNKDVQLRFARFLTSGDIARERMNHEYGWAWRQVMPLINDYNQNEEFQKEIQALLQSLSKEVESRDPRKSRLTATAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PVS5</accession>
    <name>A0A4Q9PVS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_457298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145122">
        <property type="protein sequence ID" value="TBU58693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PVS5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PVS5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="54"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="310" mass="35726" checksum="184751A1732A66BD" modified="2019-07-31" version="1">MEMAARAGGLNYIIGRVKNDVTRSKYGKRLPQNRTSEIKQARSLVHTAVDPQVRNDLRAKLADAEENYRLVQEEEEKLSKEDNHIQIEGRAFKARNDDLEKRKRAVLDARKKIEAAQLRLQNEKKKLDKLLNAKPVDVERNNLKSELLKLAGQRVTNVQQYVRLMHESIKEQEKATLAGLEYLQVQANKEALEATCKEQKEAIEVAQANFVEISQKWKKIKEDSREKLRISKEKLDACDDEIRQKFQQLEEAGEIAAKSREEWEAELAQGQEELNMNMATNANVVEQYNKRKAEVRPHVLPWSSVLLTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWD8</accession>
    <name>A0A4Q9PWD8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_925876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWD8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="149" mass="16109" checksum="A479FDB822553E1B" modified="2019-07-31" version="1">MIQLSLSTYADGTRGHGCQGTTSLTTGKLSWIGSSFHHFSVLFCSRVLTATTAPMSTDASAAGLSIARSLSCRLGCRSRLVRKGWLKSFALGRWRNNYGLSFVARLLTRNDVSAWLGSYGRASLTILRGVSYGPSSPPVELDKFASRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWF0</accession>
    <name>A0A4Q9PWF0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_435294</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU59002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWF0"/>
    <dbReference type="OMA" id="WGGLAEF"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050723">
        <property type="entry name" value="CFA/CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="CMAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667">
        <property type="entry name" value="CYCLOPROPANE-FATTY-ACYL-PHOSPHOLIPID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43667:SF2">
        <property type="entry name" value="FATTY ACID C-METHYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="193"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="532" mass="59799" checksum="E586977F85CCEC16" modified="2019-07-31" version="1">MSSLINSVVATSSSYLKPPLCTLAEKAATSLLRDISNGTFIIHTPGHTYTFGEQRKKERLFHHHHGSSSSQAPHAELTVLNPNFWLRLCAMGDLGFSEAYMYGEIDCEDLVQVFLVFLANRAQLSAIDNSFFTRIVGNLPELGLTARIVNTVTNARKNISAHYDISNGMFMGFLSRDMTYSCAIFPELDSDLRDPPSSHSLSPEEGQTPSLTGASTPATLAESEHGELLKDLSLNVYNLFAHHGEIRHAHDTESHDPLEAAQLRKLQHIIRKADIRPGHKVLEIGSGWGSMSLLITSTIPGTTVDTLTLSTQQAELARARAAAAGLSDRIRVHLMDYRNMPSEWEGAFDRLVSIEMVEAVGKEYMETYWSKIDWALNKETGVGVVQGITIPEARFEQYMREVDFIRKWVIFPGGFLPTLTFLVDTLTKGSQGRLVIDSVSNIGPHYSRTLREWRRRFQARFEDTIVPALKAEYPGVMDTDDVSARAEIEVFRRKWIYYYCYCEVGFTTRRLGDHIITFSREGNLEYGCQVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWF1</accession>
    <name>A0A4Q9PWF1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_948274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145118">
        <property type="protein sequence ID" value="TBU58987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWF1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU58987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="150" mass="15746" checksum="8163F88BDD5BCA92" modified="2019-07-31" version="1">MLFIPPAPGSVPLRTISLCLLRRYLPPQANPLQATWVPRSKSLGAIPASASSPGDARSTLVTQLRAPSSLRTMTNRQIHVRYGSGRRAAAASGVPIPSPPPDAIGWLRGSHSAACAISIARPRSSASQHCGAGARSTPACSSRFVFARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PWM3</accession>
    <name>A0A4Q9PWM3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2423 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_926526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PWM3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PWM3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28219:SF1">
        <property type="entry name" value="UPF0642 PROTEIN YBL028C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2423" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU58774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="147" mass="16026" checksum="F58C420ED1B41E92" modified="2019-07-31" version="1">MAKSTRSKVKRHFRAKKREQGVYAATEAARLHRLNMKLKVLITTEKDEETPEGDAGAEGESGEWVDDGAADGQAPSDENANGADAMDLDPAPGPSTEKKISTHGPRNSRREQWRASKGLPARPKSKGTNRQGGIAARRKAGRPSRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PXQ1</accession>
    <name>A0A4Q9PXQ1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_924853</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145113">
        <property type="protein sequence ID" value="TBU59517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PXQ1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU59517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="126" mass="13541" checksum="01053C2B1F30AA3C" modified="2019-07-31" version="1">MATPPAPAPSPATAPTSCPVPALLSLGRQRPAEVPPTLRWPPTSILSYLGPYILIQASIYLSSRRPREPSALRCLVPTRTCHISVPPPPTAHLTHSARLSLVTGSVPTYWLSGPAAYMFRPPVLCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PY92</accession>
    <name>A0A4Q9PY92_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_849469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Secreted</location>
            <location evidence="1 6">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the fungal hydrophobin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145115">
        <property type="protein sequence ID" value="TBU59274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PY92"/>
    <dbReference type="STRING" id="114155.A0A4Q9PY92"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23507">
        <property type="entry name" value="hydrophobin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001338">
        <property type="entry name" value="Class_I_Hydrophobin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01185">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00075">
        <property type="entry name" value="HYDRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0134">Cell wall</keyword>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020815824" description="Hydrophobin" evidence="6">
        <location>
            <begin position="20"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU59274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="112" mass="10804" checksum="5CA3F42EB6AD2D1B" modified="2019-07-31" version="1">MFSRVAAFALVALPLLAAATPLEGRGEPASSCSTGPVQCCNTVTTASDPAAAGILGLLGIVLQDLTVAVGLSCSPISVIGVGTGNACSANAVCCQDNSLGGLISIGCVPVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZB2</accession>
    <name>A0A4Q9PZB2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal peptidase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_924417</name>
        <name evidence="10" type="ORF">BD311DRAFT_765207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
            <strain evidence="10">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface. Essential for viability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPCS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143466">
        <property type="protein sequence ID" value="TBU25161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145111">
        <property type="protein sequence ID" value="TBU59684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZB2"/>
    <dbReference type="STRING" id="114155.A0A4Q9PZB2"/>
    <dbReference type="OMA" id="FWDDGHG"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016089">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU25161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU59684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="178" mass="20093" checksum="35B9D460E0618D74" modified="2019-07-31" version="1">MHSIYSRINNVSAMLSTCLMVLLGAISLSSFLFTSTPPPGTLAVTNVKVFPGNARRYANKYQDFAFVNFNLTADLKPLFNWNTKQLFIYVSAEYENRQGTKNEVVIFDRIVQNKEDAYIDIAGRNKYVFRDVSASFEDSTPAHYSLKYNVMPYVGILTYGEAARTVDPVPFPESQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZG5</accession>
    <name>A0A4Q9PZG5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_358573</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZG5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="76" mass="8145" checksum="8E64F8A190A0D978" modified="2019-07-31" version="1">MHPTSCPAFAVPSFCSTVRDSSPPVLGPGKTLAYAPSNQNAWDISTSREEIATAAFAKLPSACYDDNLPRHLYCSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZJ5</accession>
    <name>A0A4Q9PZJ5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_923723</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145108">
        <property type="protein sequence ID" value="TBU60030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZJ5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="194" mass="21081" checksum="58C3A9EA7AA4FA1F" modified="2019-07-31" version="1">MATTSMNRHTLCTCSMCTELDPIGQWIPTTTSLSHERMARRMNSPFYQRGRGRATVTGSRARRDTLRGGRGATSNLLRGSRGRPPTRSGAVSIPSSVPASIPTKRVRTTSPLNTLLRDEALESSTTPFDDLVPADIDYLIDGPTGRLGVEDLQDLTKNFPHSADLLLDGGDDAPMRQATISDERAQLNTSEAQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PZQ6</accession>
    <name>A0A4Q9PZQ6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BD310DRAFT_1038272</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145110">
        <property type="protein sequence ID" value="TBU59824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PZQ6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="198"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="428"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="613"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="645"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="970"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1054"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="645"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="986"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1023"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1058"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1068"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1082"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="TBU59824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1152" mass="127870" checksum="B54A205A136C5D53" modified="2019-07-31" version="1">MAHKQGEPYSGKNPVPVIAIKLTSLISPEKATDAKAKQLQDSSARREAKDTRKTADKLAKGHVMHVEDPTTGEELDICNADEEPDTRSKGENVLHNDFSPPDWQAHRDHVLSIANPSVVYTSLAFLASFLLSIIFPSWHWRVLLALPPALISYVLLFRLNHAAEADFEQRVWHSERMRGLAAGSDVDHDGNVTDEERTKESAEWANAVVRGLWPIINTDLFSSLIDMLEDIMQSSAPTFIHSVRIADMGLGSNAGRVTSIRSLADVYGGEGANGEHKDSIEGLGIDVDTITPEDRDALDGDHINLEVSFAYQGLPSGKTAQSKAQNIHLMVEFFLGLKNSWGFRIPVWVEITGAVGTARTRLQLIPDPPFVKTTIVTLMGLPRITISVVPMSRALPNIMNLPFISGFISSAIDTAAAEYVAPKSLTLDLQRLISGDDIKKDTEAIGVVVTHIHRATNIKKMDATGSSADPYVTLTYSRLEKPLYSTRIIKGDLNPVFEETAVLLVDVNTVKLREKISFQLWDSDRMSVDDMMGFVEIDLVDLIRHRGKPVRRVSPLASPDSRNRPGSLEYTVGYYGKLPPNKALTTDGTDPNIPDDLRGKEELKDAKAVALNDIEAAVLVTPPDPEWQSGILSMQVHEIRDLSVKTMGRERKGGKGREGEKGQDTGEETEEEDQGLPSSYCILSLNDELVYETRVKPITSSPMFNAGTERFLRDWRKAHVAVTVMDSRMRESDAVLGTVFLKLTEVFVNASEVTRFYSLEKGLGTGRIRISLLFRPLEAKLPPSLLGFETGTLDIRAISVESAPDDLTQCEVRLKTTTGEAEEKVSYKTVERRDGSLVWSPTSETKLPVRQRYAAALLISFRDKSGFKSSGRKALAVLWLRDVVDRAEGPVECALWRAKGGDYSRLKYNYVPPNGDLSYWDSDREKVEKVGTVRIDMAFWPGVGEKHYEMLHGGRGSRKRTSWNEYDRQKMGGMRDEVGEMNVRVPKPDDHSSKENNATKKTEDQQSEEQKDKTLTGGPINDAHGDNEDARNDAKGEGLNTAVSADEVQVVSPDGSEAGAHAAGADGNDSEGDFNDNDNGDGGERPRKRSLMEKVKDWRQHEKELHRDHRGIMQAKPVRTAEWIKDNVKDSVHNAKDHFKMKTRQPDVETEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q000</accession>
    <name>A0A4Q9Q000_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_350066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145107">
        <property type="protein sequence ID" value="TBU60166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q000"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="304" mass="34129" checksum="81A6711E021E8C16" modified="2019-07-31" version="1">MALDAIPPHCSTCVSMLQRATASREHGRIPSLGFLPSCTGTPFLPMMMWSERHWWILEFSTSSYSGLALTPPSPMLHAGGREWGHKKNRDFCHVRRQWSVILVILKPKFCATKHCGQDRYLRPEDTYYGVCLRFLLSPLLHSGCSREPALSRAPTASRIPQSTFLSAAHDVHHRCFQIRVRCSPRTMLCVRPSAHDSPTVSLDVRTEYHTSLLRLLKSFSECFQRRFAEGTQRASGLRHKASAVSVFCFDPTSEACFDRILRSCPSPSKSLASCMNGVPALAISMPRSSVLLALSITHLYEHAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q0C3</accession>
    <name>A0A4Q9Q0C3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_922719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145104">
        <property type="protein sequence ID" value="TBU60563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q0C3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU60563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="155" mass="17059" checksum="906996DB11644BEB" modified="2019-07-31" version="1">MGRTRRARARARAREGRARRSRRGGRASSASCSGGATHWTAATAAAAVARKTGMISIETRIRPLRARCGRSSPSRTKCDSAGCPDPRPVLQLIYRGLRDFSDRLCDAVVCCAWLGLIYPFVILMQHNALWVLTTHNILSSNMSDACCWGRSPSFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q108</accession>
    <name>A0A4Q9Q108_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_846883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145102">
        <property type="protein sequence ID" value="TBU60735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q108"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q108"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU60735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="361" mass="39179" checksum="88CCD77535B4E405" modified="2019-07-31" version="1">MNAPACSAPHFASDAYSPTHAYEAYDPPSLAPEYALSGYDHFVYSPQWTDASDGYAFTYSETHEQLSGAFFTTEVMCPSTAVLSVPIPVPSPLHSDRQTPLLYDTQGRYESLCGTNFADWRFPACVESMGYNSPPISLSQALPSTPALCISPDLVYPTGRDECDGVSLANECLPPTTPNASHPNRSARRAARAASRSSSHSSSSASPSPVAEPHPGTSPRLVASTRRNAQVPSPNAHSSSSLIRTNRWACPHCPYVQHNRRSPDLKRHIETHTHGADVAMWVCCGVYALDALDQGVPVEVVRQGQIMDFDGVPMIGGCMKTFSRKDALMRHLKAQKGKCFGDAWSMYQPGNRLKDGEGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q1Q5</accession>
    <name>A0A4Q9Q1Q5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutathione transferase</fullName>
            <ecNumber evidence="2">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_921581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="2"/>
    <dbReference type="EMBL" id="ML145100">
        <property type="protein sequence ID" value="TBU61143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q1Q5"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q1Q5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000156">
        <property type="entry name" value="Glutathione S-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01150">
        <property type="entry name" value="Main.1:_Beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU61143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="236" mass="26594" checksum="C08BAECB03747395" modified="2019-07-31" version="1">MAAPVASNTDTVPKLIVHHLNDSRSQRILWLLEELEVPYEIKKYQRTAERLAPPELKAVHPLGNAPVITDGDLTLAESGAIIEYIIKKYGNGRAQPPESGWLDDLYYTHYAEASLMPILVNKIIFKIIPERSPFLIRPLLRSVFNQVSALMLNPRLKTHVQMIEDHLAKTNGWFAGGEVPTAADYMMIFPLEALDSQDKTVLGSKTIEYVKRAHERPAYKRALEKGGEYVYAKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q249</accession>
    <name>A0A4Q9Q249_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">ATP synthase subunit d, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_921173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase d subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q249"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q249"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008689">
        <property type="entry name" value="ATP_synth_F0_dsu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036228">
        <property type="entry name" value="ATP_synth_F0_dsu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12700">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT D, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05873">
        <property type="entry name" value="Mt_ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005514">
        <property type="entry name" value="ATPase_F0_D_mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161065">
        <property type="entry name" value="ATP synthase D chain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0138">CF(0)</keyword>
    <keyword evidence="6 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU61303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="173" mass="19261" checksum="B7D7817FC0B5CF9D" modified="2019-07-31" version="1">MASKAVAATVDFARIYTSLGLGKETIASLQAFRKRHADAQRIQAQLASQPTTVDLEHYRSILRNKAVVDEAEKILRDFKPVTYDVNTQIKAIEAFEAKAVAKAKETTEKIDAELKDLQATLANIEEARPFEDLTAEEVGKAHPRIVEAVETMIKKGKWTVPGYKEKFGDLSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q2Z0</accession>
    <name>A0A4Q9Q2Z0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6534 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_813617</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q2Z0"/>
    <dbReference type="OMA" id="MFFETIH"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045339">
        <property type="entry name" value="DUF6534"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40465:SF1">
        <property type="entry name" value="DUF6534 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20152">
        <property type="entry name" value="DUF6534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6534" evidence="1">
        <location>
            <begin position="145"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="306" mass="33815" checksum="8757BAEEFAB373D7" modified="2019-07-31" version="1">MGALLISVVVLYYFTRYPNDPAYLKLLVAAVTTSDTIHQALITHSVYWYLVTEYGNPKALTMLVKTILVEVVVQGFTGFLVQGFFTMRVWKLSKGKLYLVIPVAAMVLTELGMTLAYGIISLSRLETFADLAQIKSVSACMNVFAAVPDVTIAAILCTILHRSRTRFSKSNTLINRLIAFSINTGLLTSVCACISLITFFALPNTFVYICFFFLIGRLYSNSLMATLNARKSLRDGSSNEASISLRDVHGTTGTNLAHYNVSRAEGIAIRIDTTKDMKRDPGSETDVIQDNESAQYDHQTKQVMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q3S2</accession>
    <name>A0A4Q9Q3S2_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_920244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145097">
        <property type="protein sequence ID" value="TBU61556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q3S2"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU61556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="232" mass="24856" checksum="C477E12461FADF28" modified="2019-07-31" version="1">MSAQQNASTSSEALPSKAGIVVFPGFEPLDAFGPIEALYTLSNEFKLDLYVIAATLDPVYTGLNDPQLNKAGSHFGVNIVPTHTHETVPDDLEVLLVPGGAGAAAPTVAPTVEFIKKVYPKLRYLITVCNGAAVAAAAGVLDGKRATTNKSYWTMLTSLSPNVKWVPTARYVVDGNCWTSGGVSAGIDVTLGWISKLYGEERARTVANIMEYEWRHDPNWDTFAYVFGVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-03-27" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q4J2</accession>
    <name>A0A4Q9Q4J2_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_974801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="2 3">CBS 464.89</strain>
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    </reference>
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        <source>
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
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                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
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            <strain evidence="1 2">CBS 464.89</strain>
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</entry>
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
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                <person name="Hilden K.S."/>
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    </evidence>
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</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Ahrendt S."/>
                <person name="Ng V."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="3 4">CBS 464.89</strain>
        </source>
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        </source>
    </evidence>
    <sequence length="1099" mass="115977" checksum="8755CCD1257C4600" modified="2019-07-31" version="1">MTSSIAARRPPPSFTPTQPPDEGYLNRSLLDNIDAQGDAEPVSSSDSEAAGASATTFGSLSTASSLGSPSIPFHLNMQSQLVPPRSDSPNHHALGPLKSSQHSTDFLQNNNTTHAMYNNITSIGLPASEFPLSSTEPDALNYTSKADGSFAAAPFRTSTAFSPFHRPRHPNPSFRDTSSAFPNSTYPSSNDLFGASQNPISRLPASQPQSALPHPLDSLQHTGRSFDFAPGPPQFNGSVSANGASHNKQLYALDAFRQGLDSTPTLLPKQPGAASGGQSLLQNSQHPHQQAFQAPYMNGLGGHSLVPGHHAQPQFGAHLSASGAGPGQGGAPGNGVTGAPNMNQTNGPAPSSQAQEEISTIFVVGFPDDMSEREFQNMFTFSVGFEAATLKIPNKESTSYGNANAQGARPGGLPMTFGGSNDPYNIVTMNQGGVLIDGGRDGPMTSWPSSAPNDEGHFMQNNVPMQPPRKQIIGFAKFRTRAEALEARDVLQGRRVDVEKGAVLKAEMAKKNLHTKRGPGVGPLGLPPFPGSATGTGAPDSMSGHPGLPAAGEALTQRDKQLGALGAMGIDLSGFPQRRDRLFDGRDEEDRDRRRGDFATIGIGAFGTRGPRERAEEDERERERRRKEEVARMRQNSFAFEAFHSVPQQMVRQGANSLLSAENGIVPNGLNLPSSPPALQSIPSQSEGMSGPWGNLRDVGASAALRKMGVPQHHMSGLPPRPQSPSATSPPTFEAITNGSVGSQNGHSAPGSRGTQFSPDSTPSSLPSHPSLPSRPPRAQSPSSEPQSYSQSSQPNSKPPSVSGSQSGHEDELVRSVGALAVSTESGSTSPQLPSPASGTSSGGGRNGSDQNPPINTLYVGNLPTSTSPGGHTLSFLEDRLRELFLKQAGYRKLCFRQKSNGPMCFVEFESVEFATKALNDLYGDTLNGLVRNGGIRLSYSKNPLGVRTPNSGGNGPSLQQQQQQYQSREMQDGSRDAFSGDPYPRHSESTDTIRGVRRDTSSMTSPASSYRYTTSPPPPRFFSPPLPSGTFSGSLATSTSFPRANPQGFGFSSGNTTFSPFGIPHSSIPDQPVADASNDHLAHPLTPAAANIEASRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7L1</accession>
    <name>A0A4Q9Q7L1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PAP2-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BD310DRAFT_808450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7L1"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q7L1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="587"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="801"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="840"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="878"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="903"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="800"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU63523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="945" mass="101165" checksum="81CBFAF0482B8217" modified="2019-07-31" version="1">MTTIALSGGTLSNGTMHRRKSSKDENEDNVLVFPPSPAPQSPPATAPLTQGSKTNSFPASETGTLEPPPSRARVTSTPSAISVSQSFPGAPTSAGPYRTSFNVPPRPPPLNGSAYGHTNGRPQPPGMRQSFSLPSAHSQAHSRTRSISGPFSPITPSPLSSSFPPQQLVMPPNKFSSSSTAPELRPPVSPIENGAKPKAAPPRRHSRIHSRNLSVYFPRPGSLPATSIAEDGAQELDFSTPPPDESILMPSASPRPGQRDFREGFTFGARPPAPAGQSSHPISSEPTPPQPSSAGGPSRRGHHHRHSMSHSFFSFLEPGAQSMPDELHTQPTPVPVSPWAPISPFPSQMSVHALDDAAASVAVTGAANGLGFGNGVAVGGGRAKSKGAAIGRIRASAQVSPVAIGVSVWQFVLGAWLWITGQQVGSLACTGLGYWVVFDAFGVALGHVLPNYLTRPSMQAETRRPYGNARVETVMAFAQSVYLIFTSVYVCKETVEHLLLSSGEGHHHHQGDEVASVLGIEFPIRLLFITLISLLSTAIFFNNHAKLVSTAGNRIPSLASLLPSRSRYSASAFTYPPALNNLFTNPYALAPIGFASAVLFTALSLPASQHRPFDLILAGLETIVTFNIAYHAAVQLGAVLLQTSPARGLAGGRMEAFLRAMREIERHPQVLHLPAPHIWQLTPSLAVSDADVVSSPYASAAAVALEKAQGPAQSLVVTLELHVRHDLEDAEVLKLTRWAWERCVHALHFGTRGGEGGEGEAEVTAEEDETRLPIWLYALDRTNRIVTSLTAVVVLYTRSAGVAYFAASAVLCSVTVKIIKRMVRQPRPYLIVRGKKKKSYGMPSTHSATITYFATYITLACAYLPIHPAFPSSPLMRIFPPLIVIPLASTIAWSRISLGHHTVFQVAAGVTCGLVYAPLMFRLWTHKLNQYGPWAEALVHTYIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q7Q8</accession>
    <name>A0A4Q9Q7Q8_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_916397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q7Q8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="278" mass="29820" checksum="B88A0DCDCFE02EE5" modified="2019-07-31" version="1">MSRSPSPSGAASPAAPHDHSPSREDSEAVSVPSGQERGQSEATDDSESKSRDDASAEPTPSPSAANAASASTSESSSASPSASAASQGTWQAVWSPAHSAYYFYNSVTQETTWVNPLQPTAEAGPSNTSTSEAPSSSKAGPSQQQPTSSIPNYDLYTAAAAQGIDPALAHLDPSLVTAGSSTSAAFTYTAKFNARTGTFARPDGRDPTHLSEYERAKRMSEFYFDVNAWENEVAQRKLEEAHEEEEGRKRKRPTKKDLERFKEQKKQKKLAKTAWLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q8L9</accession>
    <name>A0A4Q9Q8L9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BD310DRAFT_944980</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML145089">
        <property type="protein sequence ID" value="TBU63371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF356">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER ABC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="806"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="940"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="984"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1040"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1064"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="160"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="503"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="827"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1126"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU63371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="1374" mass="153286" checksum="90DD483167F39996" modified="2019-07-31" version="1">MTRNSRLLSFHLSWVLLFTLGVYVFRDVVPLFVKYRSPADSPDGIILWVKLFVLFEAAVAIPLVAPRVYEPHDPDEPMEHPNKNQTASVLSSILFNWLNETISKASRVSHLPLDDLPVLANTYTTTNLITESFPHVDPFQLGKDEHLFWGLLRVYRRKYLIYSALVFISSILALSRPIAVKGLLASIEVGGQKSDVYPWAWIVLLFVGPTLVTLQEEWAQWIMNRLNIRNDAIVTELLFEHALRIRVKSETSRSADEPQEGGNAGNAGNASEKRGNLVGRLNNLVASDLENVRQGNKMWLQLFVKVPILIAANISFVYGVLGYSALIGLASIIALLPVPGYLSKRIQRYQIEKMNKTDSRVQLISEILNVIRMIKLFGWETRVAGQVKARREAELKLLRKSRFVELVNNCSNFSIPLFTMAITFGAYTTFQHGVLTASRLFSSYTAFMTIQQQLHLIFFAIPVVTQAKVSLDRLNAFLHDTELLDQYEEIKHGTVHREQIRHLREPDIIGIKQTAFKWASDSKAQTTVTPSGTRQREFVLNIDEELLFKRGQINLVVGPTGSGKTSLLMALLGEMHAIPAGPESFVALPRAGGVAYAAQESWIQSETIRENILFGAPYDEKRYNKVIKQCALERDLTLFDAGDKTEVGEKGIALRCARITLARAVYSSAEILILDDVLAALDVHTSRWIVDKCFKGDLIRGRTVILVSHNVALIRPIANFLVALGSDGRVVSQGSLDEALQKDRELLEELKTEEALHQADTELERPKIDGHDTSDGKLVIAEEISEGRVGWNAFLLYTRNTSTHNWLYWTFYIATLCMTHALINGESYFLGYWAAQYEDHDPSEVPVPFYMSIYFGIITAILFIYAVCWSTYVYGSIRASRNIHSDLVATILGTTLRWLDMTPTSRIVARCTADIQAVDTNIPSTLHYVLEGTVFMLSRIAAVMLITPMFILPAFVVSVIAGWVSQIYMRAQLSVKREMSNARAPVLAHFGSAIAGIISVRAYGAQETFKSESCLRMDRYNRAGFVQDALSRWINIRLDVLGNSLSTVLAAYLVYVAHISSSGAGFAMSMAVGFSGFILAWLRTLNDFQVMGNSLERIQQYMTIEQEPKSSITGVPPAYWPASGDLRVEKLSARYSPDGPRVLHELSFEVKSGERIGIVGRTGSGKSSLTLSLLRCIPTEGAVYYDGRPTDTLNLEALRSHITIIPQMPELLSGTLRQNLDPFEQHDDATLNDALRSAGLFSLQEEGDHGRITLDDDIAGGGGNLSVGQRQIIALARAIVRRSKLLILDEDYETDSIIQKSLREELGRDVTVLTVAHRLQSIMDSDKIMVLDAGRLVEYDAPSALLERQDGYFRSLVDGSSDRTALYAMAGVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q934</accession>
    <name>A0A4Q9Q934_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Small GTPase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BD310DRAFT_807487</name>
        <name evidence="13" type="ORF">BD311DRAFT_736655</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">CBS 464.89</strain>
            <strain evidence="13">OM18370.1</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143393">
        <property type="protein sequence ID" value="TBU32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU64093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q934"/>
    <dbReference type="STRING" id="114155.A0A4Q9Q934"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="TBU32965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="TBU64093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="21425" checksum="D7DECF72196EB896" modified="2019-07-31" version="1">MTGELLTQRKIAVLGSRSVGKSSLVIQFIENHFVESYYPTIEGVFTKTINYKGVDYNCDIIDTAGQDEYTILNSKHAIGIHGYVLVYSVTNHKSFDMIQVVYDKIINFCGKNSIPCVIVGSKIDLQNNRPSRQVQKKEGEKLAEDLAAAHIETSAKENINVAKVFELCLAEIEKRQPNNKAEPETSRCHIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9Q9Q7</accession>
    <name>A0A4Q9Q9Q7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9Q9Q7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="71" mass="7755" checksum="2D000E15E6240003" modified="2019-07-31" version="1">MRVSRLSFHRRVPTNVPSVLNSLRLLGTCAAHAGSRSAGELDRSQTRSIGDSVHSSIRSGLLSYDSRQCQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QA66</accession>
    <name>A0A4Q9QA66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_459116</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145087">
        <property type="protein sequence ID" value="TBU63941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QA66"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU63941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="183" mass="20144" checksum="AE64F23A7A77C543" modified="2019-07-31" version="1">MSGSSLRQRLFPFSGTQNFQERSQALKADSTHLELGRDGRHLLSEAPGHGQQQRDEVVSPETMHSALGNHDTLNSFQRARQSDSQRSRLILGSRYLSPKADDSSDDAHPYPRPGSVMSMVPQTSLTLVSPRGFPGNQCSIPRESLPQAPQTTSNVSQSRPFSEKRPAKSLRQRLDPGAPHFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QAM1</accession>
    <name>A0A4Q9QAM1_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">FAD/NAD(P)-binding domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914962</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QAM1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QAM1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="568" mass="64367" checksum="404C8B3F04FB2648" modified="2019-07-31" version="1">MSPSPPKRICIVGAGASGMSAAYAFSKHPDKFTVTVFDKQSVAGGMATSIDIDPSKYGATYINDGVQGCSPAFANTLRMFKTLEFEATEVGMQISFGKGEDFWSNVFPSKLVAEYKKDIAKFGRALSVIKTFEVAFAMIPVHAMLRIFRFSSGFGERMVYPLVALFFGTGNQTPYISSAILERVFMDPSMKLFEYNDKSLLASIPTMLAFPKLHDAYQAWKEDVESRGNVHFRFNCEVLRVVSRTAKESGPVQIEFKASDADSGNGPQIAAFDELILAIDADSALKLLGKEATWKEKRILGSVKYLYDVTITHNDLDYMDKYYEIRYNPKLNAPLASEDDAQQRQEMEEAFDFASKSFRPLYYTMQYAQDRSKIEMSFDLTHYQPQFRGEQPAGPIPSDDPANQQYNGGLPDHAQKARDETARKAGEAVRTGQDEKGVSEPPLEKHVFQTIFLDKDGSQDLWTFNEIDKDKRIYEKWWKQQSHRWQHYATVVPWMMFINGKQNTHYAGAWSVLNMHELAVTSGFAAAYRLGADYPFHGDEDCERLFRLYLGLSHGTRMRKEDRKGFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBH7</accession>
    <name>A0A4Q9QBH7_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">lipoyl(octanoyl) transferase</fullName>
            <ecNumber evidence="3">2.3.1.181</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_913026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="3"/>
    <dbReference type="EMBL" id="ML145085">
        <property type="protein sequence ID" value="TBU64640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QBH7"/>
    <dbReference type="STRING" id="114155.A0A4Q9QBH7"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993:SF7">
        <property type="entry name" value="LIPOYLTRANSFERASE 2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10993">
        <property type="entry name" value="OCTANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21948">
        <property type="entry name" value="LplA-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="6">
        <location>
            <begin position="41"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU64640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="268" mass="29691" checksum="EA0D12EDEFCDBC08" modified="2019-07-31" version="1">MSMSLPPIFYHCFKTPLPYTKALVLQEHIHAHQLLSRKTSHHHRDYLLLLEHRPVYTFGRRQLESSEEITLEASRLKGLGADCVSTKRGGETTYHGPGQVVGYPLIDLGRTSPPMGIRDYICRLQKTLEAHLLEAHGIQHIPSEHTGVFLGPHTKVASIGVQVRHRLTTHGFAMNITEEPLAWFDRVVACGLTDVKAGCIARASSTAPNPSSISVAAELPGLITRFGRVIGRDMVELDVSAEGEVEDAIRAIERDAVEMDPWPRTPMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QBS5</accession>
    <name>A0A4Q9QBS5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_914180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <source>
            <dbReference type="EMBL" id="TBU65163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
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</entry>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
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                <person name="Ahrendt S."/>
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                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
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            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
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            <begin position="14"/>
            <end position="40"/>
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        <location>
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            <end position="188"/>
        </location>
    </feature>
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            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6534" evidence="2">
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            <begin position="173"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20152"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="341" mass="37424" checksum="8A2AFDEBFE02D8A9" modified="2019-07-31" version="1">MGSLSAAAEFADKFFGGLLVEVLIACVLYGVTTLQTFIYFQKYPNDSPYVKLFVAAVWILETVHTAFCIHVVYGYLILNFADVENFGKIYWSIGITVITEVVLSTMVQSFYVRRVWIMSNYRRLLTGGIAFCVVCRIAFGIGSTVLSYRFREWSAFRAQKSSLVTVSGGLGAAALVDVLVALTLSWYLSRGRSDFPQVSKSRVNLIMLYAVNSGAITAAASVLSVILYATQSKSLVFLGIVEIQGKLYANSFLGSLNARAHIRSKNNPVQYPSFESYSNNGFRAPPVPKVEVFQQTMVTTDLGLHNVGHELENVSAIPRSRSSSVSRLLKTQSADGHGIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
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            <taxon>Polyporaceae</taxon>
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        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
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                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    <proteinExistence type="predicted"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU64604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="80" mass="9013" checksum="20384BBE1779BB78" modified="2019-07-31" version="1">MIGDSCCRYMFPEEFVWWSTCRQRAAIPCADPATHRSKRPPGPSRSQFQYCFGCVILMVRRATAWALGVGTTPPTLCRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QE08</accession>
    <name>A0A4Q9QE08_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BD310DRAFT_865414</name>
        <name evidence="11" type="ORF">BD311DRAFT_714764</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
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            <taxon>Fungi</taxon>
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            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">CBS 464.89</strain>
            <strain evidence="11">OM18370.1</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <location evidence="1">Autophagosome membrane</location>
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        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATG8 family.</text>
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    </dbReference>
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    </dbReference>
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    <dbReference type="OrthoDB" id="6738456at2759"/>
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    </dbReference>
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        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="Ubl_ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="TBU32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="TBU66063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="118" mass="13701" checksum="C96647E2390B6305" modified="2019-07-31" version="1">MRSKFKDEHPFDKRKAEAERIRQKYPDRIPVICEKADKTDIPTIDKKKYLVPSDLTVGQFVYVIRKRIKLAPEKAIFIFVDEVLPPTAALMSAIYEEHKDEDGFLYVSYSGENTFGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEA1</accession>
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        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
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                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEA1"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEA1"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020215025" description="SCP domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU65576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="45610" checksum="E383757A42B480A8" modified="2019-07-31" version="1">MRVSTFLAIVALALSAHALPLPSALSSADASLSTTVDGAAAPSSAIASSIADTTFAPSSTIIDSSATTPTDSAASTDATDSSAPTDSGSATVTATDSSADASATDSSASPTDSGVDASATDSSALPTATDSSSDPASTSTDTSTDTSAAPTDTSTDSAAAPTSTGISFDVPAVPSACLALPSGVVTSAAAPTSSATFSVTDTASDASATAVSSSFDNSTSTAVAPASSSVANATATDIASVTSSGADATATDSASASSSAADATATASASGSSSSSNATSIASDASVATDVPTSTADSIASATPTDGSATDSTLVRRIAQDDILALAQSWQDLCLASGGDIYTNEPCVQLAGVNGINALQADADPCAQQDNADAMIDFANSPGVTNSVALIANAVAYRQHARNAVNINGVLPSNPYCQRAPRNAELQGLVNAQLPEVDPFIFGSSQLGLFAFGADGTCPFGQTPDPTTCSCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEP8</accession>
    <name>A0A4Q9QEP8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligosaccharyl transferase subunit OST3/OST6 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BD310DRAFT_963484</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEP8"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEP8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5020940822" evidence="10">
        <location>
            <begin position="19"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="TBU65726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="318" mass="35248" checksum="20A569BA28EBB212" modified="2019-07-31" version="1">MLLLLPLLALLSIPFCLAAPSAESAHEQLVKLAAANNGLIKLDDNLYNLLTHPNRNWSASIHLTALDPRRRCAPCKEFDPSFTAVAKAWSQVPKPQRDNHFFATADFDDTMATFQRLGLQSAPVVHIHLPVEGDRRPASGRTAPIVYDFSNGFDAGPLAEQLSVYTPVPIPYKAPIDWAKYGTAVGVGLIILSGIRVFLPILRSRWAWAAGTVITSLVMTSGFMFVRIRGMPQSGANGQWIAPGYQNQFGQEVQVVSFIYGLLSAAFLMLTLVTPYQTQPYRQRAQIYLWSGVILVMFSVLISLFRVKNRGYPFKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9QEU3</accession>
    <name>A0A4Q9QEU3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AMP-dependent synthetase and ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_911198</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9QEU3"/>
    <dbReference type="STRING" id="114155.A0A4Q9QEU3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859">
        <property type="entry name" value="ACYL-ACTIVATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43859:SF4">
        <property type="entry name" value="BUTANOATE--COA LIGASE AAE1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="57"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="482"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="568" mass="63089" checksum="E07BF18BC7CA273E" modified="2019-07-31" version="1">MAHIQLAEEFYMANEALKSFTPTSASIPPPGVNYRLRLPSGTPVHLHALNPLAFVLRSAQIYSNKLAIVHPDVRHPVIYSYAVWAQRIQNFAYGLLEAGIQPGDRIAFIAPNMSAYHGVLGARAIICAINTRLTHGEVAYILEHSGAKLIFVDHESAHLVKGAKAPVIVVNDTGKEDDPYEQFLTSGRKFSNERGWAGLEWERNEDAGCALNYTYVAPPHQTGRERFVVDVVIGSYLAAVANAYDTGMNRDSTYLWILPMFHASGWTFPWAVTFASAAQICLRSVSYPHIWNHLINSGVTHYCGAPTVQIGLINAPMARRLEKPVFAIIAGSAPTAHLIGELEKRNIKPVHVYGLTCTYGPSTVCYYQPDWTSRALDERARLLARQGHAFATAEEVRVVFPLKEGESLDAPLVDVPKDGQTMGEIVFRGNIVMKEYFKDPEATRKAFRGGYFNSGDLAVWHPDGYIAIMDRSKDIIISGGELSTHPDVLEVSVVARSHPKWGERPMAFVILHPQKAEKWAGRHSEFEKDLKEHARKRLPGFACPEWVSIVPELPVSIIVLEEVVRVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K0U0</accession>
    <name>A0A4V2K0U0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PLC-like phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_129947</name>
        <name evidence="2" type="ORF">BD311DRAFT_754979</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143407">
        <property type="protein sequence ID" value="TBU30223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145205">
        <property type="protein sequence ID" value="TBU53766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K0U0"/>
    <dbReference type="STRING" id="114155.A0A4V2K0U0"/>
    <dbReference type="OMA" id="YYFETPF"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF140">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5040684252" evidence="1">
        <location>
            <begin position="20"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU53766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="307" mass="32954" checksum="85575674C8271AE3" modified="2019-07-31" version="1">MRAASIFLSVAAAIASVKGAIVPQRRADVCNGHAELCNRSYGNVTFLGAHDSFAFSDDPLALSADQRVDIPTQLGLGVRLLQAQAHVNDGVLHFCHTSCLLFDGGSVEDYLTKVHDFLTANPNEVLTFIFTNPENASLTELWDPPFQASGIADLAYVPPSIPVKQSDWPTLGELIDSGKRVIVFLDKGADTDRSVPYILPEFPMVWETPFSVTNASFPCSVDRISGPLATEDHLYMINHSLNKNLFDTGIIISDPLDASKTNSVSSILANAAGCQGFAAGRAPNFVLLDWVNTGHGLDAVNQLNGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K7F7</accession>
    <name>A0A4V2K7F7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_979209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145159">
        <property type="protein sequence ID" value="TBU55988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K7F7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="342" mass="37233" checksum="15C5356D30552C67" modified="2019-07-31" version="1">MSSNSTAAPATLTLPPGLVPLSLVQEELKWLLLETIYSAFLVPIAIVLFFFSTPHLRRQPTFILNVCAIALGIAQGGIGIANSVNALVLNLSATPTAAIASVYLFLLVPFCVQAILVLRVLAAYPPKSLPPSRRLVIYGPIIIFKLARIANLIYMAVRLEQLIQAGGGLSSNSVFTVSQAVWTLPSAKAEWFLQLFDDMYASTLFILRLRKGTGMLGRQPTVERLHTTSAKSTYLQRLKTLFWIAVFNFVFPIIFNIAVLILAFRDSNFLDGSYIIYTNNYVEIIGVLLATIWAAGSHKDDGDNSSGLLGSSQTAGSHGNIHLVKMTSSSTFHVSETVEAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K8K0</accession>
    <name>A0A4V2K8K0_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SigF-like NTF2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_815528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K8K0"/>
    <dbReference type="STRING" id="114155.A0A4V2K8K0"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057514">
        <property type="entry name" value="NTF2_SigF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35393:SF1">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24840">
        <property type="entry name" value="NTF2_SigF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SigF-like NTF2-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU60288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="281" mass="31603" checksum="4D5C2BA674C72866" modified="2019-07-31" version="1">MDNPEKEIAGVLSLVTSGIKPEMQKESIQRYYTKDVPYRHPFFAVLRSANSRPTLVGLFQWFRIVLPKYRVDVERVTYDEDKNELFLDSRCVALLPWSSLSLERTVLVHMKLRAETSPDGDPDKVLHYIAEQEDFLRPDDVIALFAPPLVPLALLVLHFATFMCVLGTFFVNLAQPWVVRASDGLEDTSRHIAEEGRRVIEEGRHPVHNSRRLLNGLAQQVERTWDQAAEKEKNVHVDGSGGRRSENKPPSGVAGDPGGTAYAEAAREAMGEMQEKGVNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4V2K950</accession>
    <name>A0A4V2K950_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_918553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145093">
        <property type="protein sequence ID" value="TBU62508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4V2K950"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU62508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="78" mass="8463" checksum="E444D5ABBB31E549" modified="2019-07-31" version="1">MQCIISCICDRVVLISGLNGACPFGCLLSSAVYLRLICAHVSASFSQLEMRPWGTTSKIRRRCGYPSSGEYGNAVQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MIC8</accession>
    <name>A0A4Q9MIC8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_956770</name>
        <name evidence="2" type="ORF">BD311DRAFT_760932</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143435">
        <property type="protein sequence ID" value="TBU27169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MIC8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU27169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="347" mass="37680" checksum="4A4D50B451F82B3B" modified="2019-07-31" version="1">MDLQQLSAALKQPQVTLITVDTSDGIEHSPLSVFRRFATASTMKTIKNILAIPPKSPPKSSFIGSSNAALCKECSKKFRPTITDQVHCSVNCERLSSWMELNEQHRGMMQHRRRPRTTPVRDLDAVIHEVTQSSPTRSTHSSSEKVCLAGPSTLPRLESKPILRTSSSKAETGRPRRVLRKRHPSSFDGSRAPPCLVPSVISSSTSSSPLRTSFAVSASSSESDMLYMAPLSYADPDDTLASARLALHNLSSPTLSQPVRPRFSSTMTASRSPSYGVTPFLARKPSHPISSTSRPIPTRSITHAAGQAPPTSPPDSPARLRPGNDRRAPRPRSNSFGGFDSLVMHGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MJT6</accession>
    <name>A0A4Q9MJT6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BD310DRAFT_882293</name>
        <name evidence="9" type="ORF">BD311DRAFT_865865</name>
    </gene>
    <organism evidence="9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="9 11" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">CBS 464.89</strain>
            <strain evidence="9">OM18370.1</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="ML143428">
        <property type="protein sequence ID" value="TBU27759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145148">
        <property type="protein sequence ID" value="TBU56654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MJT6"/>
    <dbReference type="STRING" id="114155.A0A4Q9MJT6"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="404"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="TBU27759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="TBU56654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="449" mass="49920" checksum="28C685D57016C957" modified="2019-07-31" version="1">MTASSRPVASLPELRAITVESLDPADVPLLRIKTDEDVQLWKCTRGYQDYGLFLRRLAESIVGLNLPHPAPERNQAVSRVIGLLDKLDGWIDEIPPLPTPQRFGNLAFRTWGRRLEEKSTSLLRELLPESRYAVIPFIEPYWLTSFGSFVRMDYGTGHETSFALFLLCLTLVRFLKPEPEIERQVVLHLFVRYLRLCWRLQDVYKLEPAGSHGVWGLDDYHFLSYIFGSAQLRDQKEIPVSAVLHPPLPPTNLYFMSIMRIHEVKSGPFHEHSPQLYSIATGVQYWHKVHSGLFKMYEAEVLGKRVVVQHIPLGGLLPWDVPQSQSQSQYRSSFPSTNAAPFTQAVTAAPWASSTTAAMTTPPSTTLSTRTPHTVALPRSGYGYTTRPPAGVSPPPIVPGRMPLGPTASTALRATVTPGVAPRTMAPPPPSTASHPSSGQDYVGGRSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MJY4</accession>
    <name>A0A4Q9MJY4_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial import inner membrane translocase subunit tim23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BD310DRAFT_935295</name>
        <name evidence="5" type="ORF">BD311DRAFT_760751</name>
    </gene>
    <organism evidence="5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 7" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">CBS 464.89</strain>
            <strain evidence="5">OM18370.1</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="ML143434">
        <property type="protein sequence ID" value="TBU27257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145183">
        <property type="protein sequence ID" value="TBU54688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MJY4"/>
    <dbReference type="STRING" id="114155.A0A4Q9MJY4"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU27257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU54688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="199" mass="20786" checksum="16AD55053B4F44B8" modified="2019-07-31" version="1">MAGARDTVDYSLLKDDQIDAMASSGSDLLLGSFDPSKLHPLAGIEDKLDYLQLDDDKTSDLPGAGGAIPSRGWSDDLCYGTGTMYLSGLALGGVWGLREGARRPLAVSNARLRINSILNSVTRRGTFIGNSAGCLALVYNAFNSSIDHFRGMHDTYGSMAAGALTGALYKSTAGVKPALAAATFISGLAGLWSYVKTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MKZ5</accession>
    <name>A0A4Q9MKZ5_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_930047</name>
        <name evidence="4" type="ORF">BD311DRAFT_758731</name>
    </gene>
    <organism evidence="4">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143423">
        <property type="protein sequence ID" value="TBU28274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145141">
        <property type="protein sequence ID" value="TBU57123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MKZ5"/>
    <dbReference type="STRING" id="114155.A0A4Q9MKZ5"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="27"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU28274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU57123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="128" mass="13997" checksum="4B93CA5DDF17AC49" modified="2019-07-31" version="1">MLATQTMSEPQAASTAPTQSHATPPELEQTLTLLTSHRSVLGYMLLSRGQPVTIIRHSGVVFEGEQGKKYASAIARIVHSVQTGLEDVSGGHNDGDDIRFMRIRTKRHEIMISPGEHYLLAVLHDPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9MYA5</accession>
    <name>A0A4Q9MYA5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RmlC-like cupin domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_802772</name>
        <name evidence="6" type="ORF">BD311DRAFT_654959</name>
    </gene>
    <organism evidence="6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="6 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
            <strain evidence="6">OM18370.1</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <dbReference type="EMBL" id="ML143395">
        <property type="protein sequence ID" value="TBU32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9MYA5"/>
    <dbReference type="STRING" id="114155.A0A4Q9MYA5"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="24"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="177"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="TBU32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU65946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="297" mass="32599" checksum="3797CD17D3DFDEBE" modified="2019-07-31" version="1">MSASRSVVKRVLSVETEEGAGAIVRRSIGTPQLRNLTPFLMLDHFHISKGAGFPDHPHRGQATVTYMLEGSSRHEDSAGHKGEIRPGGVQWMCAGKGIIHAEMPVSGDGVPEPRGLQLWVDLPKEYKMVDPTYQELDPEQVREAFPQGEDGPVKVRVISGKSHGVESPVRPLGGCWYFHVIFKKQATIFQEIPAGWTSFIYIIKGGLKVGSDSTVHPSFYTLVLSANSGENGAELTATEDGTEFVLVAGEPLDQPVVQYGPFVMTSREDIQKTLIDYQFGRNGFEKAHNWKSIIGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N2A9</accession>
    <name>A0A4Q9N2A9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_915698</name>
        <name evidence="2" type="ORF">BD311DRAFT_649558</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143388">
        <property type="protein sequence ID" value="TBU34650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145088">
        <property type="protein sequence ID" value="TBU63679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N2A9"/>
    <dbReference type="OrthoDB" id="2537650at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU34650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU63679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="353" mass="37649" checksum="09AF867D20609FDB" modified="2019-07-31" version="1">MAFTTTSHHLNPRGRNSTLRTSSDPSAESQTRAVRQNDPEYAHGSLDARSPTPTDGPVAAALPTPHDAVLAELQGLRDGGPQAAHKADASSRTVPRLSVIPSVGSLERTERTATPSAGLPRSATSTPGVAHEQLYDPFSGNLAGVMVPRKDAVGRDVTASQFDQRRDELWARLSSIRELQSEVASLHVQMEGIGLNDVRGGKRTAGVGARMHSDTIPVAEEWDEPDGAADALEEQRKRARDAEFTNLAETFKGRREAIDAIMNKLGDLSEALTTFHDLPTPVMDFSASRCTTKDSMPLSPEMGELRSPSIAASPSPELPPVLPKFVLSEAEKGVFHESPVAAAGELPPHASPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9N7P8</accession>
    <name>A0A4Q9N7P8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_1037978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145106">
        <property type="protein sequence ID" value="TBU60292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9N7P8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU60292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="579" mass="64965" checksum="B3AECB2F8EEFB6E5" modified="2019-07-31" version="1">MKLTMKLTMQFFVSGRRSHTHAGSEGKKPVTVNDLPAEVLAYISEIVQMKHWQDGSPAWGSYRWTYVSWVCRYWRWIALASPALWTTIWIDTGDRSRCNLAWVAASIERAAGAPLDVSVLLRPSGVESWGTLYDLLLPFVSAIRRFAFTFCSGLNSDLALTWFAISMVCPKGSLEVLKLGDDSQERHSSAMLLEFLTSRLRLQKLRVLELTNLHLPTSPNLSACRSLRSLSIKGVFPHPNAIDLLSILSDCPRLETLAVDFCHASTQITDRIQTSIPSVTMPSLRSLLIRGDLADTVYACDRILVLPTCIIQIFHRSVGRPLPPGIMLSIVLPKQAVFRSVISICTRVSLYIVGDIPSMEFDDSDGKMRICVHADIPSPGASTITQVWEDFTRMLSTVATTDFALGCDKLHQVTVDMWSDSLSWMPTLESLNVLGDVDVVDKMRESAPFPAAMFEALATVSTASETARCLRLRRIQLLFMVLDRITEEAFLRALQLRASLGLRLERVTFVECYRTNPVGEDFKRRIQEYADVFVVYESSSADADADANAFRTIDWKAPTTQRRKKRLFNYLTRLVSCGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NI65</accession>
    <name>A0A4Q9NI65_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptide chain release factor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_878259</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145121">
        <property type="protein sequence ID" value="TBU58704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NI65"/>
    <dbReference type="STRING" id="114155.A0A4Q9NI65"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000070">
        <property type="entry name" value="Related to MRF1-peptide chain release factor, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU58704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="400" mass="45439" checksum="5E8B84AE60AB6124" modified="2019-07-31" version="1">MFRPAFRQLRLSRNLATSRAVRAQAQTTQAPQSPDAPIVQYVRRKIEERQKLQAELSAEVLSDEDIRRVRRIKELEPLQDAWTRWKHAKQSLEETLALLSDPDPTMRSMAEEEYATLSKTVNEMVQCTFPTLLVPPSQTANLSAIIELRAGVGGSESALFVADLVRMYTRAAQSYGWNVTMLNSNVLESGGMKDAILEVKGEGAYDALRWESGVHRVQRVPATEVNGRVHTSTVGVMVLPLTEDAEPARNADDNLFTMDEIKLEVMRSRGAGGQHVNKTESAVRITHLPTGITVSMQDERSQHQNRRRAFQVLRARLMDRKLNQEMIQRRDMRRGLVGSVDRSEKIRTYNYAQDRVTDHRLGMSLKNLTSVMEGDALQDFLKALQQRHHDELLEDVLLQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NI66</accession>
    <name>A0A4Q9NI66_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatases II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_806183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145086">
        <property type="protein sequence ID" value="TBU64267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NI66"/>
    <dbReference type="STRING" id="114155.A0A4Q9NI66"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="394"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU64267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="530" mass="58319" checksum="2F860EAF9CFD37CD" modified="2019-07-31" version="1">MYNCPYFKLGPLASQHHASEYNRLKFGPNGSPLAYIPYSVQMPDHYKEMQAHQTRCAEQKAWWPHETHRKLSVKRASAHLSPCGTDSVASVNISEHTTTIDLREQLSAAISTSMIRPLTHEDRHATVHMPQPHWQTSETHPIVISTIIPSDLVLTISSQLRRPAEPYPVVFEVPSSHQLNRMIPTPFPAVVKADPPTSPQISPPPTATPLITPPSTPISPSQSIAKSIKLSSLFWVHPTVRRAFIGAEELHALPKKRSRPASLIPSALKAVFPPLKQASPASNMDIPPALPIPSNINMRLLGNLYMSSCPGKKVRLDGPVRGRNTVCRDLRSDLSRIKNVGAACIVCCLDDAELQTLGVAWSDYARTADELGIDVLRIPIPEGLAPMAPSDLDSHLSKLIESYTLRGRAILVHCRGGVGRAGVIACCWMLKLGLCGWTIPPHGVGDTSQAAPVSSGDVSCQERSERVSRETMRLVERLISVVRRRRSLKAIETYEQVKFLVDYVEFLREQASSGSSFSADLFANWGAQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-07-24" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NIA3</accession>
    <name>A0A4Q9NIA3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_974743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NIA3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045340">
        <property type="entry name" value="DUF6533"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20151">
        <property type="entry name" value="DUF6533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6533" evidence="1">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="224" mass="24581" checksum="628A03DFE6A87095" modified="2019-07-31" version="1">MSSPAGLDPATIIAVFSSIRIANNTGVAGLTFLVFDYLITFAQEVEFFWKPKLSGAGVIFLLNRYIVLVTMLLNVSGVVFTAPAHRYVFFDYIPWAVFAAKRASALSSKNLLFTAWVLLLSFVPVALNSLQFIFGLHGEVDPVFGCVIIDPINPDLSQNPRRSLPHYCSPVTVISRSCLIVADLCLVIATWIAVSRTVKLRTLATDDTPTFGAVLLRDGVMYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NKV0</accession>
    <name>A0A4Q9NKV0_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_828704</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145197">
        <property type="protein sequence ID" value="TBU54114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NKV0"/>
    <dbReference type="STRING" id="114155.A0A4Q9NKV0"/>
    <dbReference type="OMA" id="SCIKSIR"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027706">
        <property type="entry name" value="PGP_Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010021">
        <property type="entry name" value="PGPP1/Gep4"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01668">
        <property type="entry name" value="YqeG_hyp_ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09419">
        <property type="entry name" value="PGP_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU54114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="269" mass="30292" checksum="36B4D2398CAC5641" modified="2019-07-31" version="1">MPFNLPGILAPLHLLINPRLVLPSVVVKDIRQIDFQALHKAGYRGAVFDKDNCLTIPHEDCLVPELTDAWRECRETFGPGNVLIVSNTAGSHIDVGEIEAESVTHHLSVPVLRHASLKPSYSCIKSIRAYFRSLPQPVRDEELVIVGDRLLTDVIMANRMARKKLSRGAIPPDEKRALIEERDEGSGPALLDRVGPLAVWTDGLWKRESLVLRAIEKGMLKGVERWVLGPQEAAWREGLQHRFVKPVSVVEEPAESRGLVRRIWERLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NL47</accession>
    <name>A0A4Q9NL47_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_933673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145168">
        <property type="protein sequence ID" value="TBU55453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NL47"/>
    <dbReference type="STRING" id="114155.A0A4Q9NL47"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40129:SF2">
        <property type="entry name" value="KETOPANTOATE REDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU55453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="282" mass="31456" checksum="2A2BEFB92F1A9225" modified="2019-07-31" version="1">MAVMILDLLILGAGWTSTFLIPLCKERGISYAATSRSGRDDTIAFEFDPHSTNTAPFQVLPNAKTVLITFPIKVSGASERLVELYQQTHAEGPSAAFIQLGSTGIWDGGPTLQDGSHTWTDRHSKFDETNDRARAETELLALAPKVPTTVLDLCGLWGGPRNLKNWIPRVAPSKDALAKKGSIHMIHGLDVSRAILAVHEHFDRANGERWLLTDGRVYDWWDLASAWGEEGKQGKWVRELMDEHGVRALPRTPERIGRAMDSREFWKTFELEPVKGRLGEHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NLA6</accession>
    <name>A0A4Q9NLA6_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trehalase</fullName>
            <ecNumber evidence="4">3.2.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Alpha-trehalose glucohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_941017</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:32675"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17925"/>
            <dbReference type="EC" id="3.2.1.28"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 37 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.28" evidence="4"/>
    <dbReference type="EMBL" id="ML145266">
        <property type="protein sequence ID" value="TBU52108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NLA6"/>
    <dbReference type="STRING" id="114155.A0A4Q9NLA6"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004555">
        <property type="term" value="F:alpha,alpha-trehalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005993">
        <property type="term" value="P:trehalose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001661">
        <property type="entry name" value="Glyco_hydro_37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018232">
        <property type="entry name" value="Glyco_hydro_37_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23403:SF1">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01204">
        <property type="entry name" value="Trehalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00744">
        <property type="entry name" value="GLHYDRLASE37"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00927">
        <property type="entry name" value="TREHALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00928">
        <property type="entry name" value="TREHALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU52108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="756" mass="81118" checksum="4992FC904143E7F7" modified="2019-07-31" version="1">MVDWTALALSSGMLVGVARAMPQASVSSATAPSITLSTAVASPSVPLSSPVPSQIPLPPKQAWCPSEIFCAGELLQTVNLAAAYSDPKTFVDKPTSKSSHDVLAAFDAIGNTTATEGDIVTFLDTNFRGEGLELEAVALSNFNDNPAFLNNVSDPLVRAFSQTVHGYWTSLIRNTNQTALCQEGTESGPCESTLIALNHTFVVPGGRFREQYYWDSYWIVQGLIKSELFDTVKDTLENFMDEIQNFGFIPNGGRIYYLDRSQPPLFIHMLSDYVAATNDTSVLDRALPLAEKELAWWATQRTVNVTSPFTNKTYALAHYAVNNTAPRPESYLTDYLTANDPTLQTPLTADERSNLYAELASGAETGWDYSSRWAKEPLAGTATNQNPVLRSLNVRSIIPVCLNSILYKAHTLLADLYDSQNNATAASTHRNTADVFRSGVLDLFWDASKLAFYDFNLTANARSSIYSAATFYPLWNGIIPDELLSSSQNAFGFFAALNMVLNRYNGTFPVTFIQTGLQWDAPNAWPPHQYIALEALRALPSNITSNPLPTPNGTQSTFDLIPSGQIGVSEDALPAQAIAPGKNASQSGPSADVSKLNGTVVNGGNKTDGEGWAATLQRELANRYIASALCSWHATGGEIQGLLPRLSDQELNVTQSVNNTGNMFEKFSISEIDSAGRGGEYTVQAGFGWTNGAVLWVASNFGDKLVAPECPDVLQSAAATSGTTSTGGSGNNAASSARAPAAFVAAIALFAALAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NS56</accession>
    <name>A0A4Q9NS56_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_911423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145084">
        <property type="protein sequence ID" value="TBU65486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NS56"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU65486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="388" mass="42682" checksum="E3E1E05FEE773CBD" modified="2019-07-31" version="1">MSPADNSSLVHTPISHSASARLASLARTSGALSSPYPSLAPIRRAMYHVPFVPRPFPPPALADVPLEYIIDQLRRLAPHYWSRPETSDCTIVVSLDHESPSNKTHASAGVCDAFRDMGISAEMSAESFGLEDASPSAAGQSPTRKSVRPRRMIMKLHMDYLCAHSALFRGLLSGASPFDLAMETPTDALPGLPHQSAASPPRFPCILPSSTCTHPVIHLPVPDPASFHHIIHYIYFGSTSFMEEALDNGDLTWDGLARNVEYLKMGDDIKLFLGRYWRRVHTYCDYNDSDSDHEYDSASDCDSDSDACMTEDESTLADPDEDRMCLADDEDEDEDVLLVKAKAQARARDPPRGRQRTARRLGHSLSDPGISYRASEAGPCPARRNVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NTN7</accession>
    <name>A0A4Q9NTN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BD310DRAFT_946597</name>
        <name evidence="2" type="ORF">BD311DRAFT_777062</name>
    </gene>
    <organism evidence="2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 4" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">CBS 464.89</strain>
            <strain evidence="2">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143408">
        <property type="protein sequence ID" value="TBU30078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145098">
        <property type="protein sequence ID" value="TBU61495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NTN7"/>
    <dbReference type="STRING" id="114155.A0A4Q9NTN7"/>
    <dbReference type="OrthoDB" id="3357341at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU30078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="TBU61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="647" mass="71072" checksum="301EECCD4BBFCC0B" modified="2019-07-31" version="1">MSYDLFSLNFVPRQEDRTIIDLVDPKGLSYYTKRRVLTTEYKIEVYDTLSESLLASVSAPSASSKHKTLQLHNPDSVVELKSTGVLTFKWSFKWEDHEFEWKREECYILRKPDPAVLVAQTKEPPGKLQTRNVQILDYNINRFDINDRKGLEIVILTALLTFSDLNEAAHSGSLPTPTPVPASTPAAAAAPPVLSPTATSPSTSIAAPNVLAAIGTAPRLTSTAAPDGNAEAPAVPPRPAPRTGVERVAEMHALRNALGEGDVNEVSVWEECDVNDYAQYAEQLLNDEAMLFISIRSASQLQVPKVLKVVEETKRLRYKAGIAEEEELHQYVIYETEKRKGPRRINLNDPDPKKGKIPDADKYAPPTSLTIHLSKIDMPELQPKPNPATQRRASESNTTIVRAPSPQFAPPPSHPAVRPPSPPPPFMPPSYPVYHPPSPPAAPTPLAASSLPNLRSPSPPKPPAPSHPGVLPPMPVAIRELTDKERKKAEKERQRLEKEREKAAKEREKFEKKKGRRQSSAYTHVPPPPPTNMFTRPYPSPSPSPQPHPYHTPAHMVHPYQPSPSPSQLNNPGIYGAPPPHAPSPRPRPVSMAYNSSSSGVNSPSAYQPSYLSPMGSGGSRPQSVYGSRDKDGKGPVSGLLHMWSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NUW7</accession>
    <name>A0A4Q9NUW7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Quinone oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BD310DRAFT_820224</name>
        <name evidence="4" type="ORF">BD311DRAFT_669472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">CBS 464.89</strain>
            <strain evidence="4">OM18370.1</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML143460">
        <property type="protein sequence ID" value="TBU25534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="ML145129">
        <property type="protein sequence ID" value="TBU58098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NUW7"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292957">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU25534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="TBU58098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="369" mass="40128" checksum="A70A1A92D475B6F9" modified="2019-07-31" version="1">MRAILVKDGKGHAENLYLGEAEKPVPGPGNVLVKVKFFGLNRMDILQREGHYPLPPGASSILGVEFSGHVEQVGEGVTEWHAGDEVLGLAAGLVCHTHGRESIVVLTLPSQDMFPERSADNPYTTQGAYAEYIIAPRGNIIKKPAHLSWAEAASIPEVFLTAFQALVVLAEVKKGDDVLIHAGASGVGIAAIQLARLYGANTVTATASTKDKLDMLLQLPSGATHVVNYKEQDFSVEVKKTTGGKGVDVIIDFVGQSHWNKNIDSLAYDGRMTMLAFLSGAEVEKFNLAPILYKRLRIQGSTLRARSESYQADLVARFKKEAFDHITGASGDGKVRTYIHKVYPWTEIQEAHREMEANNNSGKIIVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2024-11-27" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NVE4</accession>
    <name>A0A4Q9NVE4_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_949787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145144">
        <property type="protein sequence ID" value="TBU56912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NVE4"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="366" mass="40634" checksum="795B4386C25B7B3E" modified="2019-07-31" version="1">MTSASGLHILSDSRAPGGSTDYTTLVLLHGNTIHGGTFVHLLPHAATHNARIVLVNRRDYPGATPYAPEERILLEGWSLRKYDVQTVKDNMALFMRHRAEELLTLLEELVRDGSVTRVSSSRTSGGIVVAGWSLGIVWMSALLAHISSSPRAAQLKPYLRRVVMYDPGSFMFNYPRPDDPYEPFLEPEAQESSADLLDWVSGYFAHGATVDALERREPMRYPLSSLRNVTLEDLEKMICATPGQIGGTDQMLVVGGHNSGFFGELWKRALELSPTENLNESANANDGWRGLGLHIVWCDRSVWECVHGVWGVQAEVAEAREKGRAVRDVTFTRIEGGNHFAHWDYPKETLAAMLRNDERLAVGVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NW33</accession>
    <name>A0A4Q9NW33_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heterokaryon incompatibility protein-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1036814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145096">
        <property type="protein sequence ID" value="TBU61768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NW33"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="22"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="240"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="761"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="783"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU61768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="837" mass="93007" checksum="414539B7BE0FA276" modified="2019-07-31" version="1">MRLLNTFTGAFESFDDPRAVRYAILSHVWQLASDHGQSAELSYQQLLALQDSAADPVGLFDKLSAVAPKVYHACQVAKRDGFRYIWIDSCCIDKASSAELTESINSMFDWYRSGKACYAYLHDVNDGLDPKPVTSKFCRSRWFTRGWTLQELLAPCNVLFLSKDWRPIESKYVLASTISRITGIPIPILRHEQPLSTVPVAQRMSWAYQRQTTKIEDQAYCLLGMFDINMTPIYGEGREAFIRLQQSILEHIPDQSILAWGPRAPFDSLFSITPPSHLAMPSVLSLQHHDNRYPESYLLASSPHPFISATDIAIISPESLAHDLGLDQPIRPKYETTPYGIRTKCAIMPMYDQAGIEHRLAFLACRETRFGNLVALVLCSRGSNHLDVESMYVGAPDHRYDHESSLSPYRSRSTETTGPIRLVSLSRDDVSKHRDKVIVAKVSIRYSTPNLEQLLSSDEPIHAQLQAVAPLSPALPPLVLAQWRCNLLEAQGYRVLGPTAEQPGLIVLKPDNADRGTINIHIDRCACEYGARKGGLRARVDVGGDIAHPLFLLSTRLNSIGHLPCRRDHIKEWEFHDGIATQTYASITSGQGTRFLRLSLTLDDPRSSTSPYILDVEVSESPSADVSRRLPLVGHSRAATMDYRDGGGEGERLYDHTLQSELSLSSMNRSKILSDHPSRPPSPTLSFGSGVHFAPRDLSLSLPSSATNRRNTVDTGLSSLRLLTPPQSPSGRRDHSWSTSPLGTAGNSLVSLQYSMTTTESRGRREGESRSSRGGHADHLMPNITQSPTETLSTPSSDLILEPTADTQASTPDGTDSMPKRGSRWSWTRTIRSLRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NWI8</accession>
    <name>A0A4Q9NWI8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_931181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145149">
        <property type="protein sequence ID" value="TBU56559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NWI8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU56559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="529" mass="60573" checksum="F63278F9FB30211D" modified="2019-07-31" version="1">MPEAEISDQHVFALLEEGQPLSDLLKELIGLRNWKEQQLEAQRLEALRMERMLSRICVNCKETASRWIRHQVGTTDDLPVELLHTIFRYTIPPNALLDPIATRGSCTPWIQAIAAKMTLARVSRRWHSATLPFLYEEVSFRHPTQVRSFASTLRTHPNICRLVRKIVVDCPATKEIRDLVVGDLIYILTQCTELRALAFTDSLFAMEDDLRRVALYAFPTALTAAIRALSRTLVRFEQWPQGGTPHFTWPIACVSPASLLTTLTINIDHDESLKSVELAALEELDISCQYVVPRGSDHSQRFANWRLPRLKRLIMPMAIDNQGRLLQQFGRSITYLEFRDHLDMATRWHKTPWRPYVDYIHLCPILQHLVFQEYDTSVLDLLPSHPTLTYVDIWFNSPAGHIRQDFLERCRQRRSASDLRWNVRLLDRSLNAIRQLPELFPPGVPEEELPSIHAIPGLSITHTAWGVYRSDLDILYPPEDSLEEAVSENSSSDSDSTYSSESDPSEDDSVTESEGEMLEEDEIAALASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9NYN9</accession>
    <name>A0A4Q9NYN9_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pkinase-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_312671</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="ML145103">
        <property type="protein sequence ID" value="TBU60720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9NYN9"/>
    <dbReference type="STRING" id="114155.A0A4Q9NYN9"/>
    <dbReference type="OMA" id="MKTTMPM"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU60720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="395" mass="44756" checksum="17950F9C4E52B7E5" modified="2019-07-31" version="1">MATHGPINGVKISPVDDPRKIVKVVASDGKSGETRDLIYTNCKVIGNGSFGIVFQAKLLEDSNPVCDIAIKKVLQDKRFKNRELQIMRLVSHPNVVDLKAFFYSNGDKKDEVYLNLVLEYVPETVYRASRHYAKLKQPMPMLQIKLYMYQLLRSLMYIHSIGICHRDIKPQNLLLNPATGVLKLCDFGSAKILVAGEPNVSYICSRYYRAPELIFGATNYTTNIDIWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPSREQIKTMNPNYMEHKFPQIKPHPFSKVFRPRTAPEAIDLVAKLLEYTPEARLSAVEAMCHPFFDELRQEGAKMPNGKEFPPLFDFTREELSVRPDLIRQLVPPHTEAELASRSIHLDSFVPIPLEQLRISLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P395</accession>
    <name>A0A4Q9P395_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="14">ATP-PFK</shortName>
            <shortName evidence="14">Phosphofructokinase</shortName>
            <ecNumber evidence="14">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BD310DRAFT_977746</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14 15">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="14">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14 15">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="14"/>
    <dbReference type="EMBL" id="ML145130">
        <property type="protein sequence ID" value="TBU58030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P395"/>
    <dbReference type="STRING" id="114155.A0A4Q9P395"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14 15" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 14 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="118"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="17">
        <location>
            <begin position="458"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="14">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="14">
        <location>
            <begin position="458"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="141"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="171"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="217"/>
            <end position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="584"/>
            <end position="588"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="622"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <begin position="629"/>
            <end position="631"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="689"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="14">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="TBU58030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="829" mass="90750" checksum="13EC2E35C3C62651" modified="2019-07-31" version="1">MANAIAKNKMKLAVLTSGGDSAGMNAVVRAVVKAAIIKGCETWIVREGYEGLVRGNGDSGDHRRQSLAEKTLTSPRELKTPEAPEEGFVHNLRYGDGELLKDGTSDHPGGRTLKGRYIVRVGWDDVRGWFSEGGTLIGTARSATFRTREGRLTATHNMIKEGIDALVVCGGDGSLTGADVFRAEWPGLVSELRQTGKISEEQAARHAHLKIVGLVGSIDNDMSMTDLTIGAPTALHRICESIDNINSTAYSHSRAFVLEVMGRHCGWLALMAGVSCGADFIFIPESPPDADHWADEMCKMIQSHRDVGKRKTIVIVAEGALDSKLQPIRSDHVKDILSERLGLDTRVTTLGHTQRGGRPCAIDRILPTLQGVEAVEALLEATPETPSYMIGVRENKITRVPLMDAVKMTREVADAINEKDFERAMSLRDPEFRETLDGFFATSVLESEPRLPHHLRMRIAIMHVGAPAGGMNAATRAAVRYCIRQGHKPFAIHNGFVGLLDDNIHQLSWLGVDNWTTRGGSELGTNRKSPDIDLGAIAAKFQQHNFHGFIMIGGFEAFSSLLILEQGRKHYPAFNIPMVHLPATISNNVPLTEFSLGSDTSLNALVDACDAIKQSASASRNRVFVVETQGGQCGYIATMGALATGACIVYTPERGIDLDMLRNDVKYLKRRYALDAKGKNEGRLVIRNEVASTVYTTEVIMKMFKEEGGSLFDSRSASLGHTLQGGVPSPTDRARAVRLSLKCMSFIEQQHQLLLKQQSRTKQAPPESAAVITIQGTSVKWVPVQEMVEHADMKNRRGKHTWWEQHTELVEALVARPQILAKGKKEPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7J3</accession>
    <name>A0A4Q9P7J3_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_921221</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145099">
        <property type="protein sequence ID" value="TBU61329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P7J3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="185" mass="20684" checksum="404238768900B1B4" modified="2019-07-31" version="1">MICRSCMSNVASSSSRTRALATTALRLAHTHALRHSSLLTHSRPSSRTPAHHHQQAGPSSQAREAFHTRSAAFSTTARRGADELPRENLQAIFEQKQRFLKLLQEKPEVEEHIRGFVQLLKDNGVDVSSGQMPSKLDTFRLMMKKEIRESATSMATTLQEAGIDLRNPEMMQSLMTMQSISKGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P7L4</accession>
    <name>A0A4Q9P7L4_9APHY</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_921093</name>
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        <name type="scientific">Dichomitus squalens</name>
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        <lineage>
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            <taxon>Basidiomycota</taxon>
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            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
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        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU61271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="372" mass="39948" checksum="D70717FF161350BC" modified="2019-07-31" version="1">MLNIEVSQPQQIYTKPLSQASQDSEGPVWTTLASNSTSDEEDVPDSTATTPEPAECQVVSQPLTTYAIWTQKHLIAPGSNQQPHNMSKSLQTNHGSISNLKRKAAAALDAQVCPLPEPLAKKTRLTPTLQTGSAQLKANPPTHPLLPTFSSQHTFNTSHTAPTLTDTILPAPCSEVHATSTGLNRRPRKTVTPNNATSSTTDWALVDSALQTRIATAHILSSYARSPPGCKPDGMSLRDEGWAHVPVARLADLGKGSKGKGRAQSGWTAPRWSNVGEFKARLDMMYGHGDINRGLGRGPRNVQTTFAEAVESSIAPDDIAVVGRSDQGAIRGSALTENDDSSELSLESSQGVLRRARLENSSPERDDRASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P964</accession>
    <name>A0A4Q9P964_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_785708</name>
    </gene>
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        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
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            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
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            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145374">
        <property type="protein sequence ID" value="TBU51159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P964"/>
    <dbReference type="Proteomes" id="UP000292082">
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    </dbReference>
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        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="191" mass="20607" checksum="4C16E320483E5217" modified="2019-07-31" version="1" fragment="single">MFPSNPPPEDAPARTQLTYSLLRLALLSAREAYYLESTDTGLADPLDDTSAGQLFLDLDRKFGDVCGHLLDASNLGEILEDICPPSDEDPISHNQPPMKPPSHDLSSVSLPSCAVSPVYPGRANQSLVSPSNLRPPEAPMGHTTMRPPTVAQSRSIVSSSTQHRKRKSNTSHDRTPGPSAPLPTFRSSGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9P9W3</accession>
    <name>A0A4Q9P9W3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Eukaryotic translation initiation factor 3 subunit E</fullName>
            <shortName evidence="4">eIF3e</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">INT6</name>
        <name evidence="8" type="ORF">BD310DRAFT_863510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
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                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the eIF-3 subunit E family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145360">
        <property type="protein sequence ID" value="TBU51218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9P9W3"/>
    <dbReference type="STRING" id="114155.A0A4Q9P9W3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21378">
        <property type="entry name" value="eIF3E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03004">
        <property type="entry name" value="eIF3e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21357">
        <property type="entry name" value="EIF3E_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016255">
        <property type="entry name" value="eIF3e_su6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="232"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR016255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="TBU51218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="461" mass="52597" checksum="2A89F1C86EB92406" modified="2019-07-31" version="1">MAEYDLTRTIIPYCDRHLVFPLLAHLAESDLFPVQQVQAAQYELAKETNMVDYAVSLFEQTHPDEPVPSEFAEKREKAVSTNEQLQQEAQAVLDVIENPEVAQALRQDKNQNLQFLRDHYNVTLDQITALYNFGKFQYSYGNYSGAADYLYHFRVLSTDPDLTISAHWGKLACDILTGKWDVALEELNSLRDAIDSRAPSHPQFATPSSGSADPALAQLHSRTWLLHWSLFVYFNHPQGRTLLLETFLAPTYLNTIQTSSPWILRYLATAAVLSRKSASGALSSRVRHSIREIVKVIQMEEYQYQDPVTQFLKELYVEFDFEAAQKELSKAEVVVSNDFFLGEFREDFMDNARYLISEAYCRIHERIDIGDLSERLNLSRDEGEKWIVNLIRETRMGADAKIDLEKNVIEIHRPPLPIYQSIIEKTRGLAFRTQALGAAMSRTQQPLGAPDSAQPTVVEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAT5</accession>
    <name>A0A4Q9PAT5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BAR-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BD310DRAFT_941537</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145284">
        <property type="protein sequence ID" value="TBU51810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAT5"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAT5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050384">
        <property type="entry name" value="Endophilin_SH3RF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167:SF116">
        <property type="entry name" value="CAP, ISOFORM AC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14167">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="426"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="236"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="485"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="116"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="581"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="TBU51810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="703" mass="77984" checksum="AE393882EFAE9BB0" modified="2019-07-31" version="1">MGEVIMTRDKTIQSDEFRELEHDVELRRQGLWRLDVASDEYRHYLLKKKVSEVTGTDDKVLALDALGVVMIKHGEEFGDESAYGQSLVSLGRAHCNVATLQESYAMTLEETYLTAVRQSEDEIKEYQTQRKKLESRRISYDAAAARLEKLKHAKKVPEKDREEAEEELETAKARYEETMEDVRTRMYSIQENEVIQLRELTNFLDLEINFVHSYLDELQKVRSAWVDEDTLKKLGASKARPSPRPTPASRSGSIRSAKSIKKQAEEEAAQSSADEQRPTMSRKKSLSRKKSDVAESKPPSRAPSRASRKRSDSTATAASEKEDKEKEKPKPEKSSHRLSVAGWSVSSMIGRGGKKDKEKEKNNKEKFAELDSDLSETDEFGVTKPPHKRRSSVPGLPSTSPKLPARLLKSFSNGGEKEKDSGKDKENYKRVVALHDFAAGSTDELSFKAGDQIEVISEVLDGWWMGELEGRRGLFPTTYTEIINSSQTSLPPPLPHRPSASVTRALGLSNGAKKSTSSYSSLEDGHPFGDHQARNGKSSKVYEDSIQSSNFSDDDESSSLMHVQRIDDALSSKYVTGLPAPTSPAVPVPTSLPPPVPVRRDTTSGSPAKKAPPPPPPRRSTLSVNAPTPPPVPSRPGTLRTKSSTSSSYSSLALTGTAAADPDGLTYSPFDSPRDESTRFDCREFKQNPFKPQGFCSNCFKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PAX3</accession>
    <name>A0A4Q9PAX3_9APHY</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BD310DRAFT_1010810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">CBS 464.89</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="ML145393">
        <property type="protein sequence ID" value="TBU51115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PAX3"/>
    <dbReference type="STRING" id="114155.A0A4Q9PAX3"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="83"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="436"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="41"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="TBU51115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="545" mass="59455" checksum="FD52BE88BC54C060" modified="2019-07-31" version="1">MFTFRCKPNKSEDNGGPPFIRTSPSLPELSAQGIPWPSNLVDLSQLPQDTASSPPRGAAKTSFTADAAHPVPFHEPWLSPGTPPYVFNVMVAGAQGVGKTSLLRLLLDMVDISLTATADQKAVVERFLRGPPKGTETIHSACIEICESKYDRLLLSIIDTPGLDFRKGHECKLEHQVSTIVKYLDSQFADTLNEESKVVRQSKGDQHIGLCIYTIDPSSVLTEGACHTQSPYPTKVRSEVTVSYNLLDLSSMSDDTDSEDEEDKNGLTMSPADICVMRRIAARANMLPVSHRILLRSVWRDLRAADLDFGAFGPVVMDDAARSPADERANGNWNGHGHTNSTSSSDNNNKRTAVASDPPGPSSSCARRVSRSRSRLEMSETALAEDPHVLELINDMNSVASMRFSAHIVAKTDLSAQLPLVLITPEHGTVASPSEAGVNGYGHGHGHGNGHGAGSRRESMAAPSEDVHAQSGPPVELKGVFERWLRWRTVDMLNLEHCDFGKLWTAASLLKIWTKEVLYEKCRTEKLLASIWRVVALRCPPLAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PBF8</accession>
    <name>A0A4Q9PBF8_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_833073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145270">
        <property type="protein sequence ID" value="TBU52039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PBF8"/>
    <dbReference type="STRING" id="114155.A0A4Q9PBF8"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871:SF1">
        <property type="entry name" value="CXC1-LIKE CYSTEINE CLUSTER ASSOCIATED WITH KDZ TRANSPOSASES DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35871">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU52039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="371" mass="42557" checksum="6C63C4BC5975B654" modified="2019-07-31" version="1">MAASELAARANLFSGKWGARLIREWTQAWVRTRTLPESERGRHTKVVSLLSDPTVRAAVRTYLRSEKWSQNPLKLQKMLNNELSSEEAREYRRVLESEEMPDGLKKFVASEILPRYHLKPGRMGLSRSSMRLGAAHDGKRYSWLLHGESFLKKKGPGRGLHQSDFICSTVGWLANASVTLEYGKNHDGFWNGEMFCKQLIEKFFPAFEAAHGPGHIAVIFVDNSQGHSCYAPDALRASKMNLNPGGVQPRMRDGWYDRDGRRVTQTMVFPADHPDHPNQPKGIKAVLMERGLWQHCDYTFDTLRENMPKALRSVSVELIRKWEHRAWRFIDAYTEGLGAREAQKKVKEFSSHRYKSHRRVPEQLAQAMDIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD41</accession>
    <name>A0A4Q9PD41_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_971033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145274">
        <property type="protein sequence ID" value="TBU51965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD41"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="517" mass="55932" checksum="5165E942A5CD2DAE" modified="2019-07-31" version="1">MESSRNDSNGTSTYVNNIIPTTSAPSSLSVFNLSHPPPWRSSHSLSNLGSTIHHDELLLARSQWPISAEVGNMIVAEPSYPQVEESSQSRAVLSPPQALIVSDQASGSANFSQRGATISASGDESNAVATRFIPNSTTPTSTQELSVTTVACAVFYGGIVSAPDCEHFQLFPSLSLRSDQVHRSGDEVHTVGLDVLLQTLQTSLISSMSPFNIDWLLDVLSAPDFPVAFLFATSRAIPSEGLDYRSPRNLFRLIYPNCTSLLPLTYPFSPSSLDALLSLDSQCRSNVTLLETLRLFGASSTRACFTLFIERVQLAPESSMAGRVAHFVPLPQYQQGSSTTADAGPPVLTPAMASAGLQIDTLCKTRGCSSDSLYAARYTSQQGRAGVLADMVYNHAAMASILRSCGFTMEDMKHGDSCCHIQGITLSCSNILANFGWQHTTFKKGIIRHSHGQRIAATSWPVTFSVDSQDYVYWQDTCYLWSATGPLGPGYNPASATRTTLSARTFDSWAPKWPRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PD82</accession>
    <name>A0A4Q9PD82_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_983074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145491">
        <property type="protein sequence ID" value="TBU50982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PD82"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU50982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="51" mass="5648" checksum="3C138337DAEB5E89" modified="2019-07-31" version="1">MQEPTHTKRATASRKGKEREGAQPDIADRIIALRGKQATAPDPLILQLLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PDN7</accession>
    <name>A0A4Q9PDN7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BD310DRAFT_422742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145412">
        <property type="protein sequence ID" value="TBU51071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PDN7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="TBU51071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="159" mass="17232" checksum="E24B2441E40B1954" modified="2019-07-31" version="1">MTFATCFHPFLARLSHKLPPSYRASIRQNAPLVPRSSSITNGNSSITMMSERSSISALPRADGIQVVGGKMGWTGSDRDAGSVKRENRRTMRPVKFATMSDSITSDAFPSSCWARTHESPSVMSWHSGSAPSLTSPLRQSFRAQPAVAVLQCHPRPAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEF5</accession>
    <name>A0A4Q9PEF5_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_162860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145218">
        <property type="protein sequence ID" value="TBU53294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEF5"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU53294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000292082"/>
        </source>
    </evidence>
    <sequence length="66" mass="7530" checksum="A415106B8D0BC013" modified="2019-07-31" version="1">MILELLRTASVPRVFLKETRQYRSYPRLSSVLPPKQNVLQALPRSSTIPQVVFDSGESLRRAIMMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-07-31" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A4Q9PEF7</accession>
    <name>A0A4Q9PEF7_9APHY</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BD310DRAFT_953310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Dichomitus squalens</name>
        <dbReference type="NCBI Taxonomy" id="114155"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Basidiomycota</taxon>
            <taxon>Agaricomycotina</taxon>
            <taxon>Agaricomycetes</taxon>
            <taxon>Polyporales</taxon>
            <taxon>Polyporaceae</taxon>
            <taxon>Dichomitus</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2019-01" db="EMBL/GenBank/DDBJ databases">
            <title>Draft genome sequences of three monokaryotic isolates of the white-rot basidiomycete fungus Dichomitus squalens.</title>
            <authorList>
                <consortium name="DOE Joint Genome Institute"/>
                <person name="Lopez S.C."/>
                <person name="Andreopoulos B."/>
                <person name="Pangilinan J."/>
                <person name="Lipzen A."/>
                <person name="Riley R."/>
                <person name="Ahrendt S."/>
                <person name="Ng V."/>
                <person name="Barry K."/>
                <person name="Daum C."/>
                <person name="Grigoriev I.V."/>
                <person name="Hilden K.S."/>
                <person name="Makela M.R."/>
                <person name="de Vries R.P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">CBS 464.89</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="ML145336">
        <property type="protein sequence ID" value="TBU51351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A4Q9PEF7"/>
    <dbReference type="Proteomes" id="UP000292082">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="TBU51351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbRe
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